TK78_RS31685 ae70725205a81bac2da2bab5a2ac3ad6 408 Gene3D G3DSA:1.10.540.10 4 115 7.4E-23 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS31685 ae70725205a81bac2da2bab5a2ac3ad6 408 SUPERFAMILY SSF47203 258 406 2.09E-54 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS31685 ae70725205a81bac2da2bab5a2ac3ad6 408 Gene3D G3DSA:2.40.110.10 125 222 4.5E-37 T 09-03-2017 TK78_RS31685 ae70725205a81bac2da2bab5a2ac3ad6 408 Gene3D G3DSA:1.20.140.10 223 406 3.5E-66 T 09-03-2017 TK78_RS31685 ae70725205a81bac2da2bab5a2ac3ad6 408 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 126 223 1.1E-25 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS31685 ae70725205a81bac2da2bab5a2ac3ad6 408 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 258 402 2.2E-52 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS31685 ae70725205a81bac2da2bab5a2ac3ad6 408 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 9 115 3.7E-13 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS31685 ae70725205a81bac2da2bab5a2ac3ad6 408 ProSitePatterns PS00073 Acyl-CoA dehydrogenases signature 2. 361 380 - T 09-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 TK78_RS31685 ae70725205a81bac2da2bab5a2ac3ad6 408 SUPERFAMILY SSF56645 5 234 1.7E-57 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS23365 240f4b13d8cd1c14caf7957717de1884 405 Pfam PF12833 Helix-turn-helix domain 253 331 6.2E-19 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS23365 240f4b13d8cd1c14caf7957717de1884 405 SUPERFAMILY SSF46689 284 334 8.96E-10 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS23365 240f4b13d8cd1c14caf7957717de1884 405 SMART SM00342 247 330 2.3E-21 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS23365 240f4b13d8cd1c14caf7957717de1884 405 Gene3D G3DSA:1.10.10.60 284 333 3.5E-11 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS23365 240f4b13d8cd1c14caf7957717de1884 405 SUPERFAMILY SSF46689 232 280 3.58E-8 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS23365 240f4b13d8cd1c14caf7957717de1884 405 Pfam PF01965 DJ-1/PfpI family 25 191 3.2E-14 T 09-03-2017 IPR002818 DJ-1/PfpI TK78_RS23365 240f4b13d8cd1c14caf7957717de1884 405 Gene3D G3DSA:3.40.50.880 24 212 1.2E-48 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS23365 240f4b13d8cd1c14caf7957717de1884 405 SUPERFAMILY SSF52317 24 212 9.17E-47 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS23365 240f4b13d8cd1c14caf7957717de1884 405 Gene3D G3DSA:1.10.10.60 230 283 1.1E-12 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS19585 547dcbb331f9582d5d41b2d8edf7b4bb 207 TIGRFAM TIGR01755 flav_wrbA: NAD(P)H:quinone oxidoreductase, type IV 5 197 1.8E-47 T 09-03-2017 IPR010089 Flavoprotein WrbA GO:0010181|GO:0045892 KEGG: 00130+1.6.5.2|MetaCyc: PWY-7731 TK78_RS19585 547dcbb331f9582d5d41b2d8edf7b4bb 207 SUPERFAMILY SSF52218 6 199 1.13E-48 T 09-03-2017 IPR029039 Flavoprotein-like domain TK78_RS19585 547dcbb331f9582d5d41b2d8edf7b4bb 207 Gene3D G3DSA:3.40.50.360 3 201 2.9E-64 T 09-03-2017 IPR029039 Flavoprotein-like domain TK78_RS19585 547dcbb331f9582d5d41b2d8edf7b4bb 207 Pfam PF03358 NADPH-dependent FMN reductase 16 132 3.3E-14 T 09-03-2017 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 TK78_RS00415 61cd7aaa0ffba519d843dc85ce8503b4 351 SUPERFAMILY SSF51735 125 310 1.47E-49 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS00415 61cd7aaa0ffba519d843dc85ce8503b4 351 ProSitePatterns PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 249 265 - T 09-03-2017 IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site TK78_RS00415 61cd7aaa0ffba519d843dc85ce8503b4 351 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 131 310 4.0E-52 T 09-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 TK78_RS00415 61cd7aaa0ffba519d843dc85ce8503b4 351 Gene3D G3DSA:3.40.50.720 52 131 2.0E-21 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS00415 61cd7aaa0ffba519d843dc85ce8503b4 351 SUPERFAMILY SSF52283 45 158 1.45E-22 T 09-03-2017 TK78_RS00415 61cd7aaa0ffba519d843dc85ce8503b4 351 Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 54 342 5.8E-18 T 09-03-2017 IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0008152|GO:0016616|GO:0051287|GO:0055114 TK78_RS00415 61cd7aaa0ffba519d843dc85ce8503b4 351 Gene3D G3DSA:3.40.50.720 132 311 1.7E-57 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS27530 4c755e22cf5ffa8bec34c116a47d4b96 115 TIGRFAM TIGR01795 CM_mono_cladeE: chorismate mutase 10 101 3.3E-47 T 09-03-2017 IPR010951 Chorismate mutase, bacteria TK78_RS27530 4c755e22cf5ffa8bec34c116a47d4b96 115 Gene3D G3DSA:1.20.59.10 7 96 1.5E-20 T 09-03-2017 IPR002701 Chorismate mutase GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 TK78_RS27530 4c755e22cf5ffa8bec34c116a47d4b96 115 SMART SM00830 18 98 4.4E-21 T 09-03-2017 IPR002701 Chorismate mutase GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 TK78_RS27530 4c755e22cf5ffa8bec34c116a47d4b96 115 Pfam PF01817 Chorismate mutase type II 18 93 6.6E-17 T 09-03-2017 IPR020822 Chorismate mutase, type II GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 TK78_RS27530 4c755e22cf5ffa8bec34c116a47d4b96 115 SUPERFAMILY SSF48600 9 97 1.68E-24 T 09-03-2017 IPR020822 Chorismate mutase, type II GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 TK78_RS01250 bd9f38634400bb9acb5c3265a5f0573d 265 Pfam PF08021 Siderophore-interacting FAD-binding domain 22 132 1.5E-28 T 09-03-2017 IPR013113 FAD-binding 9, siderophore-interacting TK78_RS01250 bd9f38634400bb9acb5c3265a5f0573d 265 Gene3D G3DSA:2.40.30.10 12 132 1.0E-30 T 09-03-2017 TK78_RS01250 bd9f38634400bb9acb5c3265a5f0573d 265 Pfam PF04954 Siderophore-interacting protein 142 258 1.7E-36 T 09-03-2017 IPR007037 Siderophore-interacting protein TK78_RS01250 bd9f38634400bb9acb5c3265a5f0573d 265 SUPERFAMILY SSF63380 13 135 5.3E-10 T 09-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 TK78_RS01250 bd9f38634400bb9acb5c3265a5f0573d 265 Gene3D G3DSA:3.40.50.80 137 262 5.0E-42 T 09-03-2017 TK78_RS10330 092b6d69d9ff134c7878dd358eda7137 342 PIRSF PIRSF000355 4 341 8.5E-99 T 09-03-2017 IPR000358 Ribonucleotide reductase small subunit GO:0009186|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TK78_RS10330 092b6d69d9ff134c7878dd358eda7137 342 Gene3D G3DSA:1.10.620.20 20 309 5.6E-98 T 09-03-2017 IPR012348 Ribonucleotide reductase-related GO:0016491|GO:0055114 Reactome: R-HSA-499943 TK78_RS10330 092b6d69d9ff134c7878dd358eda7137 342 Pfam PF00268 Ribonucleotide reductase, small chain 21 305 1.2E-80 T 09-03-2017 IPR000358 Ribonucleotide reductase small subunit GO:0009186|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TK78_RS10330 092b6d69d9ff134c7878dd358eda7137 342 SUPERFAMILY SSF47240 21 341 2.32E-89 T 09-03-2017 IPR009078 Ferritin-like superfamily TK78_RS07165 ad98e42f82b07f4807bdbdc21a14d5b1 395 Gene3D G3DSA:3.40.720.10 33 329 2.8E-43 T 09-03-2017 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 TK78_RS07165 ad98e42f82b07f4807bdbdc21a14d5b1 395 Pfam PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 57 380 6.2E-39 T 09-03-2017 IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase GO:0003824 TK78_RS07165 ad98e42f82b07f4807bdbdc21a14d5b1 395 SUPERFAMILY SSF53649 53 391 2.04E-59 T 09-03-2017 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 TK78_RS17840 2d1257cfdf01dcbdbb520223e8f378d6 217 SUPERFAMILY SSF52172 1 166 9.39E-36 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS17840 2d1257cfdf01dcbdbb520223e8f378d6 217 Gene3D G3DSA:3.40.50.2300 1 119 5.5E-34 T 09-03-2017 TK78_RS17840 2d1257cfdf01dcbdbb520223e8f378d6 217 Pfam PF00072 Response regulator receiver domain 3 112 7.0E-26 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS17840 2d1257cfdf01dcbdbb520223e8f378d6 217 Pfam PF00486 Transcriptional regulatory protein, C terminal 145 217 1.2E-19 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS17840 2d1257cfdf01dcbdbb520223e8f378d6 217 SMART SM00448 1 112 7.0E-36 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS17840 2d1257cfdf01dcbdbb520223e8f378d6 217 Gene3D G3DSA:1.10.10.10 125 217 4.5E-24 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS17840 2d1257cfdf01dcbdbb520223e8f378d6 217 SMART SM00862 145 217 8.3E-21 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2085 2100 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 1580 1976 3.7E-136 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 493 899 5.2E-144 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 2644 3052 3.8E-134 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Pfam PF00975 Thioesterase domain 3660 3815 3.4E-29 T 09-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Gene3D G3DSA:3.40.50.150 3109 3260 1.8E-22 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Pfam PF00668 Condensation domain 1 301 1.3E-68 T 09-03-2017 IPR001242 Condensation domain TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Pfam PF00668 Condensation domain 1098 1392 2.7E-38 T 09-03-2017 IPR001242 Condensation domain TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Pfam PF00668 Condensation domain 2144 2443 6.7E-62 T 09-03-2017 IPR001242 Condensation domain TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3595 3610 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 SUPERFAMILY SSF52777 2332 2601 1.67E-59 T 09-03-2017 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 ProSitePatterns PS00455 Putative AMP-binding domain signature. 619 630 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 SUPERFAMILY SSF52777 190 459 1.11E-58 T 09-03-2017 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 SUPERFAMILY SSF47336 977 1046 1.96E-18 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 ProSitePatterns PS00455 Putative AMP-binding domain signature. 1701 1712 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 ProSitePatterns PS00455 Putative AMP-binding domain signature. 2775 2786 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Gene3D G3DSA:3.40.50.980 2797 2940 6.5E-38 T 09-03-2017 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Gene3D G3DSA:3.40.50.980 641 786 2.0E-47 T 09-03-2017 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Gene3D G3DSA:3.40.50.980 1729 1864 4.6E-38 T 09-03-2017 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Gene3D G3DSA:3.40.50.1820 3814 3878 4.8E-44 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Gene3D G3DSA:3.40.50.1820 3649 3764 4.8E-44 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Pfam PF08242 Methyltransferase domain 3149 3249 5.1E-11 T 09-03-2017 IPR013217 Methyltransferase type 12 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 SUPERFAMILY SSF56801 1528 2074 1.11E-158 T 09-03-2017 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Gene3D G3DSA:3.30.300.30 3513 3575 6.3E-39 T 09-03-2017 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Gene3D G3DSA:3.30.300.30 870 987 3.6E-39 T 09-03-2017 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Gene3D G3DSA:3.30.300.30 1947 2064 5.7E-40 T 09-03-2017 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Gene3D G3DSA:3.30.300.30 3023 3080 6.3E-39 T 09-03-2017 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Pfam PF13193 AMP-binding enzyme C-terminal domain 883 959 2.0E-12 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Pfam PF13193 AMP-binding enzyme C-terminal domain 1960 2036 7.4E-13 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Gene3D G3DSA:2.30.38.10 1865 1942 2.8E-27 T 09-03-2017 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Gene3D G3DSA:2.30.38.10 787 865 7.9E-28 T 09-03-2017 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Gene3D G3DSA:2.30.38.10 2941 3018 3.9E-27 T 09-03-2017 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 SUPERFAMILY SSF47336 3564 3636 1.19E-17 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 SMART SM00823 Phosphopantetheine attachment site 2061 2130 1.1E-4 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 SMART SM00823 Phosphopantetheine attachment site 3571 3640 1.4E-7 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 SMART SM00823 Phosphopantetheine attachment site 984 1052 9.9E-4 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 SUPERFAMILY SSF47336 2054 2127 1.31E-19 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 SUPERFAMILY SSF52777 1096 1292 1.33E-34 T 09-03-2017 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 SUPERFAMILY SSF52777 4 177 2.78E-50 T 09-03-2017 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 SUPERFAMILY SSF52777 2147 2319 1.07E-47 T 09-03-2017 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 SUPERFAMILY SSF56801 433 997 2.35E-170 T 09-03-2017 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Pfam PF13745 HxxPF-repeated domain 323 418 5.0E-30 T 09-03-2017 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Pfam PF13745 HxxPF-repeated domain 2466 2560 4.6E-29 T 09-03-2017 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 SMART SM00824 Thioesterase 3662 3880 2.5E-4 T 09-03-2017 IPR020802 Polyketide synthase, thioesterase domain GO:0009058|GO:0016788 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1008 1023 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 SUPERFAMILY SSF52777 1279 1547 2.67E-40 T 09-03-2017 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 SUPERFAMILY SSF53474 3645 3878 4.44E-54 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 SUPERFAMILY SSF56801 2574 3082 7.06E-161 T 09-03-2017 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 SUPERFAMILY SSF56801 3508 3583 7.06E-161 T 09-03-2017 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Gene3D G3DSA:3.40.50.980 467 640 8.4E-53 T 09-03-2017 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Gene3D G3DSA:3.40.50.980 2608 2796 9.7E-51 T 09-03-2017 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Gene3D G3DSA:3.40.50.980 1552 1723 7.3E-48 T 09-03-2017 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Pfam PF00501 AMP-binding enzyme 2614 3028 3.0E-105 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Pfam PF00501 AMP-binding enzyme 1561 1952 1.2E-94 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Pfam PF00501 AMP-binding enzyme 472 875 5.2E-105 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Gene3D G3DSA:1.10.1200.10 988 1048 3.8E-25 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Gene3D G3DSA:1.10.1200.10 3576 3638 8.9E-23 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Gene3D G3DSA:1.10.1200.10 2065 2131 7.0E-26 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Pfam PF00550 Phosphopantetheine attachment site 987 1046 2.0E-14 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Pfam PF00550 Phosphopantetheine attachment site 3573 3635 2.3E-13 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 Pfam PF00550 Phosphopantetheine attachment site 2064 2125 8.7E-14 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29765 de3f21173196c6cc4d143c99f02db107 3896 SUPERFAMILY SSF53335 3111 3264 1.55E-24 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS32240 55801b2f63d356806431965465423754 717 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 162 647 1.5E-104 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS32240 55801b2f63d356806431965465423754 717 Gene3D G3DSA:3.30.365.10 178 280 2.2E-33 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS32240 55801b2f63d356806431965465423754 717 Pfam PF01315 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain 29 140 2.3E-19 T 09-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead TK78_RS32240 55801b2f63d356806431965465423754 717 Gene3D G3DSA:3.30.365.10 574 706 5.2E-55 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS32240 55801b2f63d356806431965465423754 717 Gene3D G3DSA:3.30.365.10 357 446 5.2E-55 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS32240 55801b2f63d356806431965465423754 717 SMART SM01008 29 141 1.1E-35 T 09-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead TK78_RS32240 55801b2f63d356806431965465423754 717 SUPERFAMILY SSF54665 14 146 1.83E-34 T 09-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead TK78_RS32240 55801b2f63d356806431965465423754 717 SUPERFAMILY SSF56003 160 706 4.06E-152 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS32240 55801b2f63d356806431965465423754 717 Gene3D G3DSA:3.90.1170.50 13 128 2.7E-33 T 09-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead TK78_RS32240 55801b2f63d356806431965465423754 717 Gene3D G3DSA:3.30.365.10 129 177 6.2E-10 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS32240 55801b2f63d356806431965465423754 717 Gene3D G3DSA:3.30.365.10 284 310 6.2E-10 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS32240 55801b2f63d356806431965465423754 717 Gene3D G3DSA:3.30.365.10 448 573 4.5E-22 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS03665 794b507f68449413ed1c40d4fc31f452 493 SUPERFAMILY SSF53067 264 474 1.67E-30 T 09-03-2017 TK78_RS03665 794b507f68449413ed1c40d4fc31f452 493 Gene3D G3DSA:3.30.420.40 265 461 2.8E-20 T 09-03-2017 TK78_RS03665 794b507f68449413ed1c40d4fc31f452 493 PIRSF PIRSF000538 5 489 1.8E-88 T 09-03-2017 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 TK78_RS03665 794b507f68449413ed1c40d4fc31f452 493 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 6 252 2.9E-65 T 09-03-2017 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 TK78_RS03665 794b507f68449413ed1c40d4fc31f452 493 SUPERFAMILY SSF53067 7 254 6.48E-61 T 09-03-2017 TK78_RS03665 794b507f68449413ed1c40d4fc31f452 493 Gene3D G3DSA:3.30.420.40 6 252 5.5E-59 T 09-03-2017 TK78_RS03665 794b507f68449413ed1c40d4fc31f452 493 ProSitePatterns PS00445 FGGY family of carbohydrate kinases signature 2. 349 369 - T 09-03-2017 IPR018483 Carbohydrate kinase, FGGY, conserved site GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 TK78_RS03665 794b507f68449413ed1c40d4fc31f452 493 TIGRFAM TIGR01312 XylB: xylulokinase 8 480 5.9E-119 T 09-03-2017 IPR006000 Xylulokinase GO:0004856|GO:0005997 KEGG: 00040+2.7.1.17 TK78_RS03665 794b507f68449413ed1c40d4fc31f452 493 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 320 444 6.3E-16 T 09-03-2017 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 TK78_RS03665 794b507f68449413ed1c40d4fc31f452 493 ProSitePatterns PS00933 FGGY family of carbohydrate kinases signature 1. 136 148 - T 09-03-2017 IPR018483 Carbohydrate kinase, FGGY, conserved site GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 TK78_RS07695 75f59c38322989eb6d872c9a237c6414 98 Pfam PF06013 Proteins of 100 residues with WXG 10 91 2.6E-14 T 09-03-2017 IPR010310 Type VII secretion system ESAT-6-like TK78_RS07695 75f59c38322989eb6d872c9a237c6414 98 TIGRFAM TIGR03930 WXG100_ESAT6: WXG100 family type VII secretion target 10 96 9.9E-18 T 09-03-2017 IPR010310 Type VII secretion system ESAT-6-like TK78_RS07695 75f59c38322989eb6d872c9a237c6414 98 SUPERFAMILY SSF140453 10 98 1.96E-18 T 09-03-2017 IPR010310 Type VII secretion system ESAT-6-like TK78_RS07695 75f59c38322989eb6d872c9a237c6414 98 Gene3D G3DSA:1.10.287.1060 8 98 8.5E-20 T 09-03-2017 TK78_RS04870 b2fe4f567e9e284e338fb9bc99b714c7 276 Gene3D G3DSA:3.20.20.100 5 268 2.9E-93 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS04870 b2fe4f567e9e284e338fb9bc99b714c7 276 PIRSF PIRSF000097 2 268 3.3E-71 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS04870 b2fe4f567e9e284e338fb9bc99b714c7 276 ProSitePatterns PS00063 Aldo/keto reductase family putative active site signature. 230 245 - T 09-03-2017 IPR018170 Aldo/keto reductase, conserved site GO:0016491|GO:0055114 TK78_RS04870 b2fe4f567e9e284e338fb9bc99b714c7 276 Pfam PF00248 Aldo/keto reductase family 19 259 1.2E-45 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS04870 b2fe4f567e9e284e338fb9bc99b714c7 276 PRINTS PR00069 Aldo-keto reductase signature 197 221 5.7E-43 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS04870 b2fe4f567e9e284e338fb9bc99b714c7 276 PRINTS PR00069 Aldo-keto reductase signature 159 188 5.7E-43 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS04870 b2fe4f567e9e284e338fb9bc99b714c7 276 PRINTS PR00069 Aldo-keto reductase signature 37 61 5.7E-43 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS04870 b2fe4f567e9e284e338fb9bc99b714c7 276 PRINTS PR00069 Aldo-keto reductase signature 93 111 5.7E-43 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS04870 b2fe4f567e9e284e338fb9bc99b714c7 276 PRINTS PR00069 Aldo-keto reductase signature 125 142 5.7E-43 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS04870 b2fe4f567e9e284e338fb9bc99b714c7 276 ProSitePatterns PS00062 Aldo/keto reductase family signature 2. 125 142 - T 09-03-2017 IPR018170 Aldo/keto reductase, conserved site GO:0016491|GO:0055114 TK78_RS04870 b2fe4f567e9e284e338fb9bc99b714c7 276 SUPERFAMILY SSF51430 6 260 5.24E-87 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS28525 a4553d92203305db6886489cceddb04e 178 SUPERFAMILY SSF49777 20 174 1.19E-47 T 09-03-2017 IPR008914 Phosphatidylethanolamine-binding protein TK78_RS28525 a4553d92203305db6886489cceddb04e 178 Gene3D G3DSA:3.90.280.10 20 174 8.6E-52 T 09-03-2017 IPR008914 Phosphatidylethanolamine-binding protein TK78_RS28525 a4553d92203305db6886489cceddb04e 178 Pfam PF01161 Phosphatidylethanolamine-binding protein 41 172 8.1E-37 T 09-03-2017 IPR008914 Phosphatidylethanolamine-binding protein TK78_RS28525 a4553d92203305db6886489cceddb04e 178 TIGRFAM TIGR00481 TIGR00481: Raf kinase inhibitor-like protein, YbhB/YbcL family 41 169 1.6E-42 T 09-03-2017 IPR005247 YbhB/YbcL TK78_RS11140 a71caef078d09d59bee948338e6555a7 195 Pfam PF13420 Acetyltransferase (GNAT) domain 8 162 2.7E-23 T 09-03-2017 TK78_RS11140 a71caef078d09d59bee948338e6555a7 195 SUPERFAMILY SSF55729 8 168 1.19E-28 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS11140 a71caef078d09d59bee948338e6555a7 195 Gene3D G3DSA:3.40.630.30 6 170 3.2E-38 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS28775 9c18cf3d2a1029e76513ba15ba0dcd5d 338 Gene3D G3DSA:1.20.144.10 69 221 1.5E-16 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS28775 9c18cf3d2a1029e76513ba15ba0dcd5d 338 Pfam PF01569 PAP2 superfamily 107 222 1.2E-17 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS28775 9c18cf3d2a1029e76513ba15ba0dcd5d 338 SUPERFAMILY SSF48317 28 236 2.35E-27 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS28775 9c18cf3d2a1029e76513ba15ba0dcd5d 338 SMART SM00014 105 220 3.2E-5 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS15045 96c1532c40ac74c4cb25af4697cb450e 314 Pfam PF00005 ABC transporter 31 167 8.0E-25 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS15045 96c1532c40ac74c4cb25af4697cb450e 314 Gene3D G3DSA:3.40.50.300 7 229 4.7E-56 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15045 96c1532c40ac74c4cb25af4697cb450e 314 SUPERFAMILY SSF52540 14 229 4.47E-51 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15045 96c1532c40ac74c4cb25af4697cb450e 314 SMART SM00382 40 225 1.1E-12 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS15045 96c1532c40ac74c4cb25af4697cb450e 314 ProSitePatterns PS00211 ABC transporters family signature. 140 154 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS27520 b02f04d4eadedd52c4427b6c960d489d 606 SUPERFAMILY SSF49785 445 589 5.1E-21 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS27520 b02f04d4eadedd52c4427b6c960d489d 606 Gene3D G3DSA:3.20.20.80 3 329 4.5E-111 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS27520 b02f04d4eadedd52c4427b6c960d489d 606 PRINTS PR00742 Glycosyl hydrolase family 35 signature 35 53 9.1E-45 T 09-03-2017 IPR001944 Glycoside hydrolase, family 35 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 TK78_RS27520 b02f04d4eadedd52c4427b6c960d489d 606 PRINTS PR00742 Glycosyl hydrolase family 35 signature 88 107 9.1E-45 T 09-03-2017 IPR001944 Glycoside hydrolase, family 35 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 TK78_RS27520 b02f04d4eadedd52c4427b6c960d489d 606 PRINTS PR00742 Glycosyl hydrolase family 35 signature 229 244 9.1E-45 T 09-03-2017 IPR001944 Glycoside hydrolase, family 35 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 TK78_RS27520 b02f04d4eadedd52c4427b6c960d489d 606 PRINTS PR00742 Glycosyl hydrolase family 35 signature 14 31 9.1E-45 T 09-03-2017 IPR001944 Glycoside hydrolase, family 35 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 TK78_RS27520 b02f04d4eadedd52c4427b6c960d489d 606 PRINTS PR00742 Glycosyl hydrolase family 35 signature 539 555 9.1E-45 T 09-03-2017 IPR001944 Glycoside hydrolase, family 35 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 TK78_RS27520 b02f04d4eadedd52c4427b6c960d489d 606 PRINTS PR00742 Glycosyl hydrolase family 35 signature 143 158 9.1E-45 T 09-03-2017 IPR001944 Glycoside hydrolase, family 35 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 TK78_RS27520 b02f04d4eadedd52c4427b6c960d489d 606 PRINTS PR00742 Glycosyl hydrolase family 35 signature 296 312 9.1E-45 T 09-03-2017 IPR001944 Glycoside hydrolase, family 35 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 TK78_RS27520 b02f04d4eadedd52c4427b6c960d489d 606 SUPERFAMILY SSF51445 4 328 9.72E-92 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS27520 b02f04d4eadedd52c4427b6c960d489d 606 Gene3D G3DSA:2.60.120.260 446 600 8.5E-41 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS27520 b02f04d4eadedd52c4427b6c960d489d 606 PIRSF PIRSF006336 1 591 1.9E-169 T 09-03-2017 IPR026283 Beta-galactosidase 1-like GO:0004565 TK78_RS27520 b02f04d4eadedd52c4427b6c960d489d 606 Pfam PF01301 Glycosyl hydrolases family 35 12 326 1.5E-99 T 09-03-2017 IPR031330 Glycoside hydrolase 35, catalytic domain KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 TK78_RS27520 b02f04d4eadedd52c4427b6c960d489d 606 ProSitePatterns PS01182 Glycosyl hydrolases family 35 putative active site. 145 157 - T 09-03-2017 IPR019801 Glycoside hydrolase, family 35, conserved site GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 TK78_RS14745 6b1ee8ebe7664a5cae3ed81d8831331b 547 Pfam PF16203 ERCC3/RAD25/XPB C-terminal helicase 352 540 4.3E-49 T 09-03-2017 IPR032438 ERCC3/RAD25/XPB helicase, C-terminal domain Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167161|Reactome: R-HSA-167162|Reactome: R-HSA-167172|Reactome: R-HSA-167200|Reactome: R-HSA-167246|Reactome: R-HSA-427413|Reactome: R-HSA-5696395|Reactome: R-HSA-5696400|Reactome: R-HSA-674695|Reactome: R-HSA-6781823|Reactome: R-HSA-6781827|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210|Reactome: R-HSA-6796648|Reactome: R-HSA-72086|Reactome: R-HSA-73762|Reactome: R-HSA-73772|Reactome: R-HSA-73776|Reactome: R-HSA-73777|Reactome: R-HSA-73779|Reactome: R-HSA-73863|Reactome: R-HSA-75953|Reactome: R-HSA-75955|Reactome: R-HSA-76042|Reactome: R-HSA-77075 TK78_RS14745 6b1ee8ebe7664a5cae3ed81d8831331b 547 SUPERFAMILY SSF52540 141 342 2.48E-32 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS14745 6b1ee8ebe7664a5cae3ed81d8831331b 547 PRINTS PR00851 Xeroderma pigmentosum group B protein signature 474 499 1.1E-34 T 09-03-2017 TK78_RS14745 6b1ee8ebe7664a5cae3ed81d8831331b 547 PRINTS PR00851 Xeroderma pigmentosum group B protein signature 355 377 1.1E-34 T 09-03-2017 TK78_RS14745 6b1ee8ebe7664a5cae3ed81d8831331b 547 PRINTS PR00851 Xeroderma pigmentosum group B protein signature 290 310 1.1E-34 T 09-03-2017 TK78_RS14745 6b1ee8ebe7664a5cae3ed81d8831331b 547 PRINTS PR00851 Xeroderma pigmentosum group B protein signature 455 473 1.1E-34 T 09-03-2017 TK78_RS14745 6b1ee8ebe7664a5cae3ed81d8831331b 547 PRINTS PR00851 Xeroderma pigmentosum group B protein signature 190 212 1.1E-34 T 09-03-2017 TK78_RS14745 6b1ee8ebe7664a5cae3ed81d8831331b 547 SMART SM00487 177 352 6.6E-21 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS14745 6b1ee8ebe7664a5cae3ed81d8831331b 547 SMART SM00490 422 499 1.1E-12 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS14745 6b1ee8ebe7664a5cae3ed81d8831331b 547 Gene3D G3DSA:3.40.50.300 380 532 1.3E-16 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS14745 6b1ee8ebe7664a5cae3ed81d8831331b 547 Gene3D G3DSA:3.40.50.300 180 342 1.9E-27 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS14745 6b1ee8ebe7664a5cae3ed81d8831331b 547 Pfam PF04851 Type III restriction enzyme, res subunit 181 325 5.9E-12 T 09-03-2017 IPR006935 Helicase/UvrB, N-terminal GO:0003677|GO:0005524|GO:0016787 TK78_RS14745 6b1ee8ebe7664a5cae3ed81d8831331b 547 SUPERFAMILY SSF52540 386 526 1.24E-29 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS14745 6b1ee8ebe7664a5cae3ed81d8831331b 547 SUPERFAMILY SSF52540 280 353 1.24E-29 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS14745 6b1ee8ebe7664a5cae3ed81d8831331b 547 Pfam PF13625 Helicase conserved C-terminal domain 5 133 1.6E-46 T 09-03-2017 IPR032830 Helicase XPB/Ssl2, N-terminal domain Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167161|Reactome: R-HSA-167162|Reactome: R-HSA-167172|Reactome: R-HSA-167200|Reactome: R-HSA-167246|Reactome: R-HSA-427413|Reactome: R-HSA-5696395|Reactome: R-HSA-5696400|Reactome: R-HSA-674695|Reactome: R-HSA-6781823|Reactome: R-HSA-6781827|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210|Reactome: R-HSA-6796648|Reactome: R-HSA-72086|Reactome: R-HSA-73762|Reactome: R-HSA-73772|Reactome: R-HSA-73776|Reactome: R-HSA-73777|Reactome: R-HSA-73779|Reactome: R-HSA-73863|Reactome: R-HSA-75953|Reactome: R-HSA-75955|Reactome: R-HSA-76042|Reactome: R-HSA-77075 TK78_RS20325 a2a6ed3ae8886f97748cc0b727cff51b 136 Pfam PF13466 STAS domain 21 101 3.8E-9 T 09-03-2017 IPR002645 STAS domain TK78_RS20325 a2a6ed3ae8886f97748cc0b727cff51b 136 Gene3D G3DSA:3.30.750.24 9 104 1.5E-12 T 09-03-2017 IPR002645 STAS domain TK78_RS20325 a2a6ed3ae8886f97748cc0b727cff51b 136 SUPERFAMILY SSF52091 9 107 2.16E-13 T 09-03-2017 IPR002645 STAS domain TK78_RS25440 01a398ddab19ec89dfa8437873635d9b 309 Gene3D G3DSA:3.40.50.1110 239 303 1.3E-20 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS25440 01a398ddab19ec89dfa8437873635d9b 309 Gene3D G3DSA:3.40.50.1110 65 203 1.3E-20 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS25440 01a398ddab19ec89dfa8437873635d9b 309 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 70 292 3.0E-21 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS25440 01a398ddab19ec89dfa8437873635d9b 309 SUPERFAMILY SSF52266 66 204 3.83E-27 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS25440 01a398ddab19ec89dfa8437873635d9b 309 SUPERFAMILY SSF52266 233 300 3.83E-27 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS07770 b2c82e364e08de53b302f7a63b16f3ee 353 ProSitePatterns PS00211 ABC transporters family signature. 165 179 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS07770 b2c82e364e08de53b302f7a63b16f3ee 353 Pfam PF00005 ABC transporter 43 193 1.3E-31 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS07770 b2c82e364e08de53b302f7a63b16f3ee 353 Gene3D G3DSA:3.40.50.300 19 265 4.3E-75 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07770 b2c82e364e08de53b302f7a63b16f3ee 353 SUPERFAMILY SSF52540 21 264 3.97E-66 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07770 b2c82e364e08de53b302f7a63b16f3ee 353 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 242 301 5.7E-19 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS07770 b2c82e364e08de53b302f7a63b16f3ee 353 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 244 300 3.5E-14 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS07770 b2c82e364e08de53b302f7a63b16f3ee 353 SMART SM00382 51 250 1.5E-15 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS04905 f2dd2f6fc1159cebd9d06ba12f622230 217 SMART SM00421 152 209 3.6E-20 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS04905 f2dd2f6fc1159cebd9d06ba12f622230 217 Pfam PF00196 Bacterial regulatory proteins, luxR family 154 208 2.2E-17 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS04905 f2dd2f6fc1159cebd9d06ba12f622230 217 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 169 185 1.5E-12 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS04905 f2dd2f6fc1159cebd9d06ba12f622230 217 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 155 169 1.5E-12 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS04905 f2dd2f6fc1159cebd9d06ba12f622230 217 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 185 197 1.5E-12 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS04905 f2dd2f6fc1159cebd9d06ba12f622230 217 Pfam PF00072 Response regulator receiver domain 15 126 4.5E-23 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS04905 f2dd2f6fc1159cebd9d06ba12f622230 217 SMART SM00448 12 126 1.7E-26 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS04905 f2dd2f6fc1159cebd9d06ba12f622230 217 SUPERFAMILY SSF52172 12 144 1.85E-28 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS04905 f2dd2f6fc1159cebd9d06ba12f622230 217 SUPERFAMILY SSF46894 142 215 6.46E-20 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS04905 f2dd2f6fc1159cebd9d06ba12f622230 217 Gene3D G3DSA:1.10.10.10 132 215 3.9E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS04905 f2dd2f6fc1159cebd9d06ba12f622230 217 Gene3D G3DSA:3.40.50.2300 10 131 1.0E-31 T 09-03-2017 TK78_RS04905 f2dd2f6fc1159cebd9d06ba12f622230 217 ProSitePatterns PS00622 LuxR-type HTH domain signature. 169 196 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 SUPERFAMILY SSF52777 735 890 1.67E-24 T 09-03-2017 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Gene3D G3DSA:3.40.50.980 3260 3378 2.4E-26 T 09-03-2017 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Pfam PF00550 Phosphopantetheine attachment site 3591 3656 2.0E-12 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Pfam PF00550 Phosphopantetheine attachment site 2156 2217 8.9E-9 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Pfam PF00550 Phosphopantetheine attachment site 652 712 2.2E-11 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3615 3630 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Gene3D G3DSA:3.30.300.30 2034 2128 6.1E-22 T 09-03-2017 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 SUPERFAMILY SSF52777 2401 2623 1.89E-16 T 09-03-2017 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 SUPERFAMILY SSF52777 2820 3048 1.67E-45 T 09-03-2017 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Gene3D G3DSA:1.10.1200.10 2152 2221 4.4E-14 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Gene3D G3DSA:1.10.1200.10 655 717 2.8E-20 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Gene3D G3DSA:1.10.1200.10 3592 3659 6.7E-17 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 SUPERFAMILY SSF52777 1198 1367 9.67E-35 T 09-03-2017 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Gene3D G3DSA:2.30.38.10 3389 3467 6.0E-24 T 09-03-2017 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Gene3D G3DSA:2.30.38.10 452 532 4.5E-23 T 09-03-2017 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Gene3D G3DSA:2.30.38.10 1952 2030 5.1E-24 T 09-03-2017 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2177 2192 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 SUPERFAMILY SSF47336 2151 2218 2.36E-11 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 SUPERFAMILY SSF52777 2234 2412 2.0E-23 T 09-03-2017 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 ProSitePatterns PS00455 Putative AMP-binding domain signature. 1776 1787 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 TIGRFAM TIGR01720 NRPS-para261: non-ribosomal peptide synthase domain TIGR01720 1037 1187 3.4E-36 T 09-03-2017 IPR010060 Non-ribosomal peptide synthase TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Gene3D G3DSA:3.40.50.980 292 443 3.0E-40 T 09-03-2017 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Gene3D G3DSA:3.40.50.980 1785 1951 2.1E-42 T 09-03-2017 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 SUPERFAMILY SSF52777 2626 2832 8.78E-35 T 09-03-2017 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Pfam PF00501 AMP-binding enzyme 145 542 8.9E-92 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Pfam PF00501 AMP-binding enzyme 1627 2039 2.5E-94 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Pfam PF00501 AMP-binding enzyme 3081 3478 2.0E-86 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Gene3D G3DSA:3.40.50.980 140 291 5.6E-41 T 09-03-2017 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Gene3D G3DSA:3.40.50.980 3073 3241 4.3E-41 T 09-03-2017 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Gene3D G3DSA:3.40.50.980 1621 1784 1.0E-42 T 09-03-2017 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 SUPERFAMILY SSF52777 920 1165 2.33E-26 T 09-03-2017 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 SMART SM00823 Phosphopantetheine attachment site 2154 2221 5.4E-7 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 SMART SM00823 Phosphopantetheine attachment site 650 718 1.8E-7 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 SMART SM00823 Phosphopantetheine attachment site 3589 3660 0.0014 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 SUPERFAMILY SSF47336 644 712 6.15E-15 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 SUPERFAMILY SSF47336 3583 3658 1.44E-14 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 SUPERFAMILY SSF56801 118 662 3.01E-142 T 09-03-2017 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 ProSitePatterns PS00455 Putative AMP-binding domain signature. 284 295 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Gene3D G3DSA:3.30.300.30 3473 3591 2.3E-25 T 09-03-2017 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Gene3D G3DSA:3.30.300.30 537 654 1.2E-32 T 09-03-2017 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 SUPERFAMILY SSF52777 1369 1604 4.34E-42 T 09-03-2017 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Pfam PF13193 AMP-binding enzyme C-terminal domain 2048 2115 1.6E-5 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Pfam PF13193 AMP-binding enzyme C-terminal domain 3486 3561 1.8E-9 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Pfam PF13193 AMP-binding enzyme C-terminal domain 551 626 4.7E-14 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 SUPERFAMILY SSF56801 3072 3601 3.92E-125 T 09-03-2017 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Pfam PF00668 Condensation domain 750 1024 1.8E-21 T 09-03-2017 IPR001242 Condensation domain TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Pfam PF00668 Condensation domain 2272 2506 4.6E-19 T 09-03-2017 IPR001242 Condensation domain TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Pfam PF00668 Condensation domain 1194 1475 2.9E-45 T 09-03-2017 IPR001242 Condensation domain TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 Pfam PF00668 Condensation domain 2625 2928 3.5E-43 T 09-03-2017 IPR001242 Condensation domain TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 SUPERFAMILY SSF56801 1612 2131 8.77E-141 T 09-03-2017 TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 1653 2064 8.9E-126 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 166 566 2.3E-118 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS33685 21cbe9e6dfa413e253c744f27cbad01d 3660 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 3100 3500 1.7E-107 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS11285 2a06717ccdb312ae3bed9f28361a76ab 896 Pfam PF00754 F5/8 type C domain 790 868 1.1E-6 T 09-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain TK78_RS11285 2a06717ccdb312ae3bed9f28361a76ab 896 Gene3D G3DSA:2.60.120.260 774 892 2.2E-10 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS11285 2a06717ccdb312ae3bed9f28361a76ab 896 Gene3D G3DSA:2.70.98.40 85 299 5.9E-19 T 09-03-2017 IPR005196 Glycoside hydrolase, family 65, N-terminal GO:0003824|GO:0005975 TK78_RS11285 2a06717ccdb312ae3bed9f28361a76ab 896 Gene3D G3DSA:2.60.420.10 695 758 1.1E-10 T 09-03-2017 TK78_RS11285 2a06717ccdb312ae3bed9f28361a76ab 896 Gene3D G3DSA:1.50.10.10 347 694 1.0E-106 T 09-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 TK78_RS11285 2a06717ccdb312ae3bed9f28361a76ab 896 Pfam PF03636 Glycosyl hydrolase family 65, N-terminal domain 84 298 7.6E-27 T 09-03-2017 IPR005196 Glycoside hydrolase, family 65, N-terminal GO:0003824|GO:0005975 TK78_RS11285 2a06717ccdb312ae3bed9f28361a76ab 896 Pfam PF03632 Glycosyl hydrolase family 65 central catalytic domain 365 581 7.3E-50 T 09-03-2017 IPR005195 Glycoside hydrolase, family 65, central catalytic GO:0003824|GO:0005975 TK78_RS11285 2a06717ccdb312ae3bed9f28361a76ab 896 SUPERFAMILY SSF74650 85 298 2.01E-13 T 09-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 TK78_RS11285 2a06717ccdb312ae3bed9f28361a76ab 896 Pfam PF03633 Glycosyl hydrolase family 65, C-terminal domain 713 758 4.6E-6 T 09-03-2017 IPR005194 Glycoside hydrolase family 65, C-terminal TK78_RS11285 2a06717ccdb312ae3bed9f28361a76ab 896 SUPERFAMILY SSF48208 305 758 1.17E-90 T 09-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 TK78_RS11285 2a06717ccdb312ae3bed9f28361a76ab 896 SUPERFAMILY SSF49785 783 893 6.5E-11 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS29920 d8e882e9bced76870293d7c729c9ff3f 1206 Gene3D G3DSA:3.40.50.10210 930 1186 7.0E-113 T 09-03-2017 TK78_RS29920 d8e882e9bced76870293d7c729c9ff3f 1206 Hamap MF_00230 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase [cobT]. 868 1205 34.942 T 09-03-2017 IPR017846 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, prokaryotic GO:0008939|GO:0009163 KEGG: 00860+2.4.2.21|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 TK78_RS29920 d8e882e9bced76870293d7c729c9ff3f 1206 TIGRFAM TIGR03160 cobT_DBIPRT: nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 870 1203 9.5E-126 T 09-03-2017 IPR017846 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, prokaryotic GO:0008939|GO:0009163 KEGG: 00860+2.4.2.21|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 TK78_RS29920 d8e882e9bced76870293d7c729c9ff3f 1206 Gene3D G3DSA:3.40.109.10 638 847 1.6E-51 T 09-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TK78_RS29920 d8e882e9bced76870293d7c729c9ff3f 1206 Pfam PF02277 Phosphoribosyltransferase 866 1203 1.6E-125 T 09-03-2017 IPR003200 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase-like GO:0008939|GO:0009236 KEGG: 00860+2.4.2.21|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 TK78_RS29920 d8e882e9bced76870293d7c729c9ff3f 1206 SUPERFAMILY SSF52733 860 1204 1.15E-114 T 09-03-2017 IPR003200 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase-like GO:0008939|GO:0009236 KEGG: 00860+2.4.2.21|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 TK78_RS29920 d8e882e9bced76870293d7c729c9ff3f 1206 SUPERFAMILY SSF55469 644 854 1.15E-52 T 09-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TK78_RS29920 d8e882e9bced76870293d7c729c9ff3f 1206 TIGRFAM TIGR02476 BluB: 5,6-dimethylbenzimidazole synthase 636 841 2.0E-92 T 09-03-2017 IPR012825 5,6-dimethylbenzimidazole synthase BluB KEGG: 00740+1.13.11.79|MetaCyc: PWY-5508|MetaCyc: PWY-5523 TK78_RS29920 d8e882e9bced76870293d7c729c9ff3f 1206 Gene3D G3DSA:1.10.1610.10 858 929 2.8E-28 T 09-03-2017 IPR023195 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, N-terminal GO:0008939|GO:0009236 KEGG: 00860+2.4.2.21|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 TK78_RS29920 d8e882e9bced76870293d7c729c9ff3f 1206 Pfam PF00881 Nitroreductase family 648 815 9.4E-32 T 09-03-2017 IPR029479 Nitroreductase Reactome: R-HSA-209968 TK78_RS10980 fc117c4ab74a91354bea656d77df0da2 352 SMART SM00382 52 252 9.3E-16 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS10980 fc117c4ab74a91354bea656d77df0da2 352 SUPERFAMILY SSF52540 53 326 4.42E-69 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10980 fc117c4ab74a91354bea656d77df0da2 352 ProSitePatterns PS00211 ABC transporters family signature. 175 189 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS10980 fc117c4ab74a91354bea656d77df0da2 352 Gene3D G3DSA:3.40.50.300 22 276 1.0E-74 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10980 fc117c4ab74a91354bea656d77df0da2 352 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 254 318 1.2E-21 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS10980 fc117c4ab74a91354bea656d77df0da2 352 Pfam PF00005 ABC transporter 44 202 4.0E-28 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS10980 fc117c4ab74a91354bea656d77df0da2 352 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 252 331 4.5E-26 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS25180 6337a4283add2ee5a41bff044109206d 875 SUPERFAMILY SSF56014 656 830 9.81E-50 T 09-03-2017 TK78_RS25180 6337a4283add2ee5a41bff044109206d 875 TIGRFAM TIGR02374 nitri_red_nirB: nitrite reductase [NAD(P)H], large subunit 30 824 3.8E-302 T 09-03-2017 IPR012744 Nitrite reductase [NAD(P)H] large subunit, NirB GO:0008942|GO:0042128|GO:0050660|GO:0050661|GO:0055114 TK78_RS25180 6337a4283add2ee5a41bff044109206d 875 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 261 277 1.3E-17 T 09-03-2017 TK78_RS25180 6337a4283add2ee5a41bff044109206d 875 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 30 49 1.3E-17 T 09-03-2017 TK78_RS25180 6337a4283add2ee5a41bff044109206d 875 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 129 147 1.3E-17 T 09-03-2017 TK78_RS25180 6337a4283add2ee5a41bff044109206d 875 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 288 310 1.3E-17 T 09-03-2017 TK78_RS25180 6337a4283add2ee5a41bff044109206d 875 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 174 192 1.3E-17 T 09-03-2017 TK78_RS25180 6337a4283add2ee5a41bff044109206d 875 Gene3D G3DSA:3.30.413.10 655 791 9.0E-34 T 09-03-2017 TK78_RS25180 6337a4283add2ee5a41bff044109206d 875 SUPERFAMILY SSF51905 27 215 2.53E-39 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS25180 6337a4283add2ee5a41bff044109206d 875 PRINTS PR00397 Sirohaem Fe-binding site signature 702 720 9.8E-6 T 09-03-2017 IPR006066 Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TK78_RS25180 6337a4283add2ee5a41bff044109206d 875 PRINTS PR00397 Sirohaem Fe-binding site signature 659 677 9.8E-6 T 09-03-2017 IPR006066 Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TK78_RS25180 6337a4283add2ee5a41bff044109206d 875 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 29 317 6.1E-49 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS25180 6337a4283add2ee5a41bff044109206d 875 SUPERFAMILY SSF55124 536 664 5.56E-21 T 09-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TK78_RS25180 6337a4283add2ee5a41bff044109206d 875 Pfam PF03460 Nitrite/Sulfite reductase ferredoxin-like half domain 583 643 7.9E-9 T 09-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TK78_RS25180 6337a4283add2ee5a41bff044109206d 875 SUPERFAMILY SSF51905 176 338 3.16E-25 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS25180 6337a4283add2ee5a41bff044109206d 875 ProSitePatterns PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. 702 718 - T 09-03-2017 IPR006066 Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TK78_RS25180 6337a4283add2ee5a41bff044109206d 875 Pfam PF01077 Nitrite and sulphite reductase 4Fe-4S domain 655 791 4.8E-19 T 09-03-2017 IPR006067 Nitrite/sulphite reductase 4Fe-4S domain GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TK78_RS25180 6337a4283add2ee5a41bff044109206d 875 Pfam PF04324 BFD-like [2Fe-2S] binding domain 448 489 1.7E-6 T 09-03-2017 IPR007419 BFD-like [2Fe-2S]-binding domain TK78_RS25180 6337a4283add2ee5a41bff044109206d 875 PIRSF PIRSF037149 23 858 0.0 T 09-03-2017 IPR017121 Nitrite reductase [NAD(P)H], large subunit GO:0042128 TK78_RS25180 6337a4283add2ee5a41bff044109206d 875 Gene3D G3DSA:3.50.50.60 29 132 1.9E-23 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS25180 6337a4283add2ee5a41bff044109206d 875 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 174 199 3.4E-8 T 09-03-2017 TK78_RS25180 6337a4283add2ee5a41bff044109206d 875 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 262 276 3.4E-8 T 09-03-2017 TK78_RS25180 6337a4283add2ee5a41bff044109206d 875 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 29 51 3.4E-8 T 09-03-2017 TK78_RS25180 6337a4283add2ee5a41bff044109206d 875 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 303 310 3.4E-8 T 09-03-2017 TK78_RS25180 6337a4283add2ee5a41bff044109206d 875 Gene3D G3DSA:3.50.50.60 133 337 8.1E-47 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS33640 6a061bc2cab183deab4e84f301562331 265 Pfam PF00486 Transcriptional regulatory protein, C terminal 166 240 2.2E-27 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS33640 6a061bc2cab183deab4e84f301562331 265 Pfam PF00072 Response regulator receiver domain 20 128 3.3E-31 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS33640 6a061bc2cab183deab4e84f301562331 265 SUPERFAMILY SSF46894 148 240 1.39E-28 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS33640 6a061bc2cab183deab4e84f301562331 265 Gene3D G3DSA:1.10.10.10 147 241 4.2E-33 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS33640 6a061bc2cab183deab4e84f301562331 265 SMART SM00448 18 128 3.3E-48 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS33640 6a061bc2cab183deab4e84f301562331 265 Gene3D G3DSA:3.40.50.2300 16 139 1.3E-43 T 09-03-2017 TK78_RS33640 6a061bc2cab183deab4e84f301562331 265 SUPERFAMILY SSF52172 10 139 4.84E-46 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS33640 6a061bc2cab183deab4e84f301562331 265 SMART SM00862 165 240 1.6E-28 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS34390 8ebefa7236fea89fc15eb32464482a5f 321 Pfam PF12833 Helix-turn-helix domain 231 309 1.3E-20 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS34390 8ebefa7236fea89fc15eb32464482a5f 321 SMART SM00342 225 308 5.5E-22 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS34390 8ebefa7236fea89fc15eb32464482a5f 321 Pfam PF01965 DJ-1/PfpI family 5 170 3.6E-19 T 09-03-2017 IPR002818 DJ-1/PfpI TK78_RS34390 8ebefa7236fea89fc15eb32464482a5f 321 Gene3D G3DSA:1.10.10.60 262 311 6.0E-10 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS34390 8ebefa7236fea89fc15eb32464482a5f 321 Gene3D G3DSA:1.10.10.60 219 261 1.2E-14 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS34390 8ebefa7236fea89fc15eb32464482a5f 321 Gene3D G3DSA:3.40.50.880 6 218 4.2E-51 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS34390 8ebefa7236fea89fc15eb32464482a5f 321 SUPERFAMILY SSF52317 5 191 2.71E-46 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS34390 8ebefa7236fea89fc15eb32464482a5f 321 SUPERFAMILY SSF46689 262 312 1.32E-8 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS34390 8ebefa7236fea89fc15eb32464482a5f 321 SUPERFAMILY SSF46689 214 259 2.03E-9 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS17625 60622f076910187b102c533618042e3e 199 SUPERFAMILY SSF48498 82 195 2.47E-17 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS17625 60622f076910187b102c533618042e3e 199 Gene3D G3DSA:1.10.357.10 60 196 7.1E-45 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS17625 60622f076910187b102c533618042e3e 199 SUPERFAMILY SSF46689 2 82 6.16E-17 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS17625 60622f076910187b102c533618042e3e 199 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 14 27 9.7E-10 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS17625 60622f076910187b102c533618042e3e 199 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 35 58 9.7E-10 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS17625 60622f076910187b102c533618042e3e 199 Pfam PF00440 Bacterial regulatory proteins, tetR family 14 59 2.2E-15 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS17625 60622f076910187b102c533618042e3e 199 Gene3D G3DSA:1.10.10.60 3 59 1.7E-20 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS11920 ab4c96317702bc186f6155e30c23dc9f 462 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 386 397 6.8E-30 T 09-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 TK78_RS11920 ab4c96317702bc186f6155e30c23dc9f 462 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 128 142 6.8E-30 T 09-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 TK78_RS11920 ab4c96317702bc186f6155e30c23dc9f 462 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 208 230 6.8E-30 T 09-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 TK78_RS11920 ab4c96317702bc186f6155e30c23dc9f 462 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 250 270 6.8E-30 T 09-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 TK78_RS11920 ab4c96317702bc186f6155e30c23dc9f 462 SUPERFAMILY SSF53223 21 211 4.16E-72 T 09-03-2017 TK78_RS11920 ab4c96317702bc186f6155e30c23dc9f 462 Gene3D G3DSA:3.40.50.720 224 386 2.3E-60 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS11920 ab4c96317702bc186f6155e30c23dc9f 462 Pfam PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 217 460 8.0E-86 T 09-03-2017 IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 TK78_RS11920 ab4c96317702bc186f6155e30c23dc9f 462 Gene3D G3DSA:3.40.192.10 82 202 1.8E-60 T 09-03-2017 TK78_RS11920 ab4c96317702bc186f6155e30c23dc9f 462 Gene3D G3DSA:1.10.285.10 387 461 2.8E-23 T 09-03-2017 TK78_RS11920 ab4c96317702bc186f6155e30c23dc9f 462 Gene3D G3DSA:1.10.285.10 22 81 2.0E-22 T 09-03-2017 TK78_RS11920 ab4c96317702bc186f6155e30c23dc9f 462 Pfam PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 71 199 1.2E-48 T 09-03-2017 IPR006097 Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 TK78_RS11920 ab4c96317702bc186f6155e30c23dc9f 462 SMART SM00839 219 460 6.8E-91 T 09-03-2017 IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 TK78_RS11920 ab4c96317702bc186f6155e30c23dc9f 462 PIRSF PIRSF000185 35 462 2.2E-115 T 09-03-2017 IPR014362 Glutamate dehydrogenase GO:0016639|GO:0055114 TK78_RS11920 ab4c96317702bc186f6155e30c23dc9f 462 SUPERFAMILY SSF51735 217 461 2.49E-73 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS06600 40997cd94da78c9f8e7db20957d9ddba 314 Gene3D G3DSA:3.40.50.720 141 288 8.6E-35 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS06600 40997cd94da78c9f8e7db20957d9ddba 314 Gene3D G3DSA:3.30.1780.10 2 140 2.1E-31 T 09-03-2017 IPR023401 Ornithine cyclodeaminase, N-terminal Reactome: R-HSA-71064 TK78_RS06600 40997cd94da78c9f8e7db20957d9ddba 314 SUPERFAMILY SSF51735 11 305 2.99E-56 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS06600 40997cd94da78c9f8e7db20957d9ddba 314 Pfam PF02423 Ornithine cyclodeaminase/mu-crystallin family 37 304 2.0E-33 T 09-03-2017 IPR003462 Ornithine cyclodeaminase/mu-crystallin Reactome: R-HSA-71064 TK78_RS06600 40997cd94da78c9f8e7db20957d9ddba 314 PIRSF PIRSF001439 1 307 2.0E-47 T 09-03-2017 IPR003462 Ornithine cyclodeaminase/mu-crystallin Reactome: R-HSA-71064 TK78_RS08115 bdca24ad3ca50dee64d0c0bb91073be5 119 Hamap MF_00048 UPF0102 protein YraN [yraN]. 4 115 21.601 T 09-03-2017 IPR003509 Uncharacterised protein family UPF0102 TK78_RS08115 bdca24ad3ca50dee64d0c0bb91073be5 119 SUPERFAMILY SSF52980 9 105 6.33E-20 T 09-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 TK78_RS08115 bdca24ad3ca50dee64d0c0bb91073be5 119 Gene3D G3DSA:3.40.1350.10 10 118 3.6E-36 T 09-03-2017 IPR011856 tRNA endonuclease-like domain GO:0003676|GO:0004518 Reactome: R-HSA-6784531 TK78_RS08115 bdca24ad3ca50dee64d0c0bb91073be5 119 Pfam PF02021 Uncharacterised protein family UPF0102 11 102 8.6E-28 T 09-03-2017 IPR003509 Uncharacterised protein family UPF0102 TK78_RS31500 228c178a7ce426e5773dc4cc0697958e 195 SUPERFAMILY SSF52141 14 175 3.92E-44 T 09-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 TK78_RS31500 228c178a7ce426e5773dc4cc0697958e 195 Gene3D G3DSA:3.40.470.10 14 178 9.7E-55 T 09-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 TK78_RS31500 228c178a7ce426e5773dc4cc0697958e 195 SMART SM00987 15 176 7.4E-7 T 09-03-2017 TK78_RS31500 228c178a7ce426e5773dc4cc0697958e 195 Pfam PF03167 Uracil DNA glycosylase superfamily 18 167 1.8E-24 T 09-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 TK78_RS31500 228c178a7ce426e5773dc4cc0697958e 195 SMART SM00986 15 176 7.4E-7 T 09-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 TK78_RS24860 30307a6ee65b2266686cf4ba29ac91bd 594 Hamap MF_00572 2-isopropylmalate synthase [leuA]. 31 594 54.297 T 09-03-2017 IPR005668 2-isopropylmalate synthase GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 TK78_RS24860 30307a6ee65b2266686cf4ba29ac91bd 594 SUPERFAMILY SSF89000 423 472 2.55E-15 T 09-03-2017 TK78_RS24860 30307a6ee65b2266686cf4ba29ac91bd 594 SMART SM00917 457 593 1.0E-35 T 09-03-2017 IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 TK78_RS24860 30307a6ee65b2266686cf4ba29ac91bd 594 ProSitePatterns PS00816 Alpha-isopropylmalate and homocitrate synthases signature 2. 268 281 - T 09-03-2017 IPR002034 Alpha-isopropylmalate/homocitrate synthase, conserved site GO:0019752|GO:0046912 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 TK78_RS24860 30307a6ee65b2266686cf4ba29ac91bd 594 Gene3D G3DSA:3.20.20.70 35 428 3.3E-143 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS24860 30307a6ee65b2266686cf4ba29ac91bd 594 Pfam PF08502 LeuA allosteric (dimerisation) domain 457 592 1.4E-34 T 09-03-2017 IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 TK78_RS24860 30307a6ee65b2266686cf4ba29ac91bd 594 Pfam PF00682 HMGL-like 56 336 1.7E-74 T 09-03-2017 IPR000891 Pyruvate carboxyltransferase GO:0003824 TK78_RS24860 30307a6ee65b2266686cf4ba29ac91bd 594 SUPERFAMILY SSF51569 45 355 1.56E-94 T 09-03-2017 TK78_RS24860 30307a6ee65b2266686cf4ba29ac91bd 594 TIGRFAM TIGR00970 leuA_yeast: 2-isopropylmalate synthase 30 594 9.7E-254 T 09-03-2017 IPR005668 2-isopropylmalate synthase GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 TK78_RS24860 30307a6ee65b2266686cf4ba29ac91bd 594 SUPERFAMILY SSF110921 489 592 1.14E-34 T 09-03-2017 IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 TK78_RS24860 30307a6ee65b2266686cf4ba29ac91bd 594 ProSitePatterns PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1. 63 79 - T 09-03-2017 IPR002034 Alpha-isopropylmalate/homocitrate synthase, conserved site GO:0019752|GO:0046912 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 TK78_RS07455 8d7ba4d68ea44f76202fb9c77305924b 307 Gene3D G3DSA:3.40.190.10 66 151 1.2E-27 T 09-03-2017 TK78_RS07455 8d7ba4d68ea44f76202fb9c77305924b 307 Gene3D G3DSA:3.40.190.10 255 288 1.2E-27 T 09-03-2017 TK78_RS07455 8d7ba4d68ea44f76202fb9c77305924b 307 Gene3D G3DSA:3.40.190.10 152 254 7.0E-25 T 09-03-2017 TK78_RS07455 8d7ba4d68ea44f76202fb9c77305924b 307 SMART SM00062 70 294 5.0E-52 T 09-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF TK78_RS07455 8d7ba4d68ea44f76202fb9c77305924b 307 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3 71 288 2.4E-47 T 09-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF TK78_RS07455 8d7ba4d68ea44f76202fb9c77305924b 307 ProSitePatterns PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 94 107 - T 09-03-2017 IPR018313 Solute-binding protein family 3, conserved site GO:0005215|GO:0006810 TK78_RS07455 8d7ba4d68ea44f76202fb9c77305924b 307 SUPERFAMILY SSF53850 4 23 1.96E-55 T 09-03-2017 TK78_RS07455 8d7ba4d68ea44f76202fb9c77305924b 307 SUPERFAMILY SSF53850 60 288 1.96E-55 T 09-03-2017 TK78_RS16485 d1fceebcbff36cc17afc5963ae9a2b6b 425 TIGRFAM TIGR02467 CbiE: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit 16 199 3.8E-50 T 09-03-2017 IPR012818 Cobalamin (vitamin B12) biosynthesis CbiE, precorrin-6Y methyltransferase GO:0008276|GO:0009236 TK78_RS16485 d1fceebcbff36cc17afc5963ae9a2b6b 425 Gene3D G3DSA:3.30.950.10 119 219 7.3E-29 T 09-03-2017 IPR014776 Tetrapyrrole methylase, subdomain 2 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS16485 d1fceebcbff36cc17afc5963ae9a2b6b 425 SUPERFAMILY SSF53335 220 406 6.37E-31 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS16485 d1fceebcbff36cc17afc5963ae9a2b6b 425 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 14 198 5.2E-21 T 09-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS16485 d1fceebcbff36cc17afc5963ae9a2b6b 425 Pfam PF01135 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) 245 362 5.0E-5 T 09-03-2017 TK78_RS16485 d1fceebcbff36cc17afc5963ae9a2b6b 425 PIRSF PIRSF036428 10 413 5.8E-143 T 09-03-2017 IPR006365 Cobalamin (vitamin B12) biosynthesis CobL/Precorrin-6Y C(5,15)-methyltransferase GO:0008276|GO:0009236 KEGG: 00270+2.1.1.13|KEGG: 00450+2.1.1.13|KEGG: 00670+2.1.1.13|KEGG: 00860+2.1.1.132|MetaCyc: PWY-2201|MetaCyc: PWY-3841 TK78_RS16485 d1fceebcbff36cc17afc5963ae9a2b6b 425 SUPERFAMILY SSF53790 14 216 2.09E-40 T 09-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS16485 d1fceebcbff36cc17afc5963ae9a2b6b 425 Gene3D G3DSA:3.40.50.150 239 380 5.8E-22 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS16485 d1fceebcbff36cc17afc5963ae9a2b6b 425 TIGRFAM TIGR02469 CbiT: precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit 242 363 4.0E-32 T 09-03-2017 IPR014008 Cobalamin biosynthesis, precorrin-6Y methyltransferase, CbiT subunit GO:0008276|GO:0009236 KEGG: 00670+2.1.1.19|KEGG: 00860+2.1.1.196|MetaCyc: PWY-2201|MetaCyc: PWY-7377 TK78_RS16485 d1fceebcbff36cc17afc5963ae9a2b6b 425 Gene3D G3DSA:3.40.1010.10 14 118 2.3E-26 T 09-03-2017 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS01600 f70b94f99645e203dbbf97b16d320501 352 Pfam PF07719 Tetratricopeptide repeat 250 275 2.9E-5 T 09-03-2017 IPR013105 Tetratricopeptide repeat 2 TK78_RS01600 f70b94f99645e203dbbf97b16d320501 352 SUPERFAMILY SSF48452 69 243 6.45E-11 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS01600 f70b94f99645e203dbbf97b16d320501 352 SUPERFAMILY SSF48452 220 309 7.59E-7 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS01600 f70b94f99645e203dbbf97b16d320501 352 SMART SM00028 248 281 8.5 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS01600 f70b94f99645e203dbbf97b16d320501 352 SMART SM00028 167 200 23.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS01600 f70b94f99645e203dbbf97b16d320501 352 Gene3D G3DSA:1.25.40.10 130 308 1.3E-17 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS18285 2960bfea5844813db85bbad14dc3eb9a 360 Pfam PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 27 139 3.1E-25 T 09-03-2017 IPR006097 Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 TK78_RS18285 2960bfea5844813db85bbad14dc3eb9a 360 PIRSF PIRSF000188 9 360 5.5E-142 T 09-03-2017 IPR016211 Glutamate/phenylalanine/leucine/valine dehydrogenase, bacterial/archaeal GO:0016639|GO:0055114 TK78_RS18285 2960bfea5844813db85bbad14dc3eb9a 360 Gene3D G3DSA:3.40.50.720 156 347 3.7E-49 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS18285 2960bfea5844813db85bbad14dc3eb9a 360 SUPERFAMILY SSF51735 149 358 1.36E-45 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS18285 2960bfea5844813db85bbad14dc3eb9a 360 Pfam PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 149 308 4.6E-10 T 09-03-2017 IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 TK78_RS18285 2960bfea5844813db85bbad14dc3eb9a 360 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 297 308 2.0E-19 T 09-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 TK78_RS18285 2960bfea5844813db85bbad14dc3eb9a 360 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 184 204 2.0E-19 T 09-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 TK78_RS18285 2960bfea5844813db85bbad14dc3eb9a 360 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 140 162 2.0E-19 T 09-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 TK78_RS18285 2960bfea5844813db85bbad14dc3eb9a 360 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 74 88 2.0E-19 T 09-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 TK78_RS18285 2960bfea5844813db85bbad14dc3eb9a 360 SMART SM00839 152 360 6.0E-42 T 09-03-2017 IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 TK78_RS18285 2960bfea5844813db85bbad14dc3eb9a 360 Gene3D G3DSA:3.40.192.10 14 155 1.9E-64 T 09-03-2017 TK78_RS18285 2960bfea5844813db85bbad14dc3eb9a 360 SUPERFAMILY SSF53223 19 152 1.44E-43 T 09-03-2017 TK78_RS18285 2960bfea5844813db85bbad14dc3eb9a 360 ProSitePatterns PS00074 Glu / Leu / Phe / Val dehydrogenases active site. 82 95 - T 09-03-2017 IPR033524 Leu/Phe/Val dehydrogenases active site Reactome: R-HSA-70614 TK78_RS00185 662d251b29d6631ad065067d03ed1d85 262 Gene3D G3DSA:1.50.10.10 23 149 2.1E-20 T 09-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 TK78_RS00185 662d251b29d6631ad065067d03ed1d85 262 Pfam PF00723 Glycosyl hydrolases family 15 19 149 2.8E-18 T 09-03-2017 IPR011613 Glycoside hydrolase family 15/Phosphorylase b kinase regulatory chain family Reactome: R-HSA-70221 TK78_RS00185 662d251b29d6631ad065067d03ed1d85 262 SUPERFAMILY SSF48208 15 148 1.21E-28 T 09-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 TK78_RS30105 818e1fdea5a9b307e1233b713c0536a5 250 TIGRFAM TIGR01033 TIGR01033: DNA-binding regulatory protein, YebC/PmpR family 1 238 5.4E-97 T 09-03-2017 IPR002876 Transcriptional regulator TACO1-like Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS30105 818e1fdea5a9b307e1233b713c0536a5 250 SUPERFAMILY SSF75625 3 247 3.01E-89 T 09-03-2017 IPR029072 YebC-like Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS30105 818e1fdea5a9b307e1233b713c0536a5 250 Gene3D G3DSA:3.30.1270.10 213 248 2.3E-40 T 09-03-2017 IPR026563 Transcriptional regulator TACO1-like, domain 2 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS30105 818e1fdea5a9b307e1233b713c0536a5 250 Gene3D G3DSA:3.30.1270.10 83 137 2.3E-40 T 09-03-2017 IPR026563 Transcriptional regulator TACO1-like, domain 2 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS30105 818e1fdea5a9b307e1233b713c0536a5 250 Hamap MF_00693 Probable transcriptional regulatory protein YebC [yebC]. 3 240 34.362 T 09-03-2017 IPR002876 Transcriptional regulator TACO1-like Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS30105 818e1fdea5a9b307e1233b713c0536a5 250 Gene3D G3DSA:1.10.10.200 1 77 3.4E-31 T 09-03-2017 IPR017856 Integrase, N-terminal zinc-binding domain-like TK78_RS30105 818e1fdea5a9b307e1233b713c0536a5 250 Gene3D G3DSA:3.30.70.980 138 205 2.6E-23 T 09-03-2017 IPR026564 Transcriptional regulator TACO1-like, domain 3 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS30105 818e1fdea5a9b307e1233b713c0536a5 250 Pfam PF01709 Transcriptional regulator 5 238 2.9E-87 T 09-03-2017 IPR002876 Transcriptional regulator TACO1-like Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS13640 6fd27282791b74f292d6d7685d4669a6 459 SUPERFAMILY SSF142019 20 252 1.7E-86 T 09-03-2017 TK78_RS13640 6fd27282791b74f292d6d7685d4669a6 459 Pfam PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 61 232 9.2E-46 T 09-03-2017 IPR011538 NADH-ubiquinone oxidoreductase 51 kDa subunit, FMN-binding domain Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13640 6fd27282791b74f292d6d7685d4669a6 459 Pfam PF10531 SLBB domain 257 303 1.8E-7 T 09-03-2017 IPR019554 Soluble ligand binding domain Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13640 6fd27282791b74f292d6d7685d4669a6 459 ProSitePatterns PS00645 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. 354 365 - T 09-03-2017 IPR001949 NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site GO:0008137|GO:0010181|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13640 6fd27282791b74f292d6d7685d4669a6 459 SMART SM00928 341 386 1.8E-26 T 09-03-2017 IPR019575 NADH-ubiquinone oxidoreductase 51 kDa subunit, iron-sulphur binding domain GO:0051539 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13640 6fd27282791b74f292d6d7685d4669a6 459 SUPERFAMILY SSF140490 337 435 2.62E-38 T 09-03-2017 TK78_RS13640 6fd27282791b74f292d6d7685d4669a6 459 Pfam PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 343 426 5.5E-33 T 09-03-2017 IPR019575 NADH-ubiquinone oxidoreductase 51 kDa subunit, iron-sulphur binding domain GO:0051539 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13640 6fd27282791b74f292d6d7685d4669a6 459 ProSitePatterns PS00644 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. 180 195 - T 09-03-2017 IPR001949 NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site GO:0008137|GO:0010181|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13640 6fd27282791b74f292d6d7685d4669a6 459 SUPERFAMILY SSF142984 255 336 1.96E-21 T 09-03-2017 TK78_RS13640 6fd27282791b74f292d6d7685d4669a6 459 TIGRFAM TIGR01959 nuoF_fam: NADH oxidoreductase (quinone), F subunit 24 427 2.9E-193 T 09-03-2017 IPR011537 NADH ubiquinone oxidoreductase, F subunit GO:0010181|GO:0016651|GO:0051287|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS29990 a59648b538fef37f6a4af5944c525845 279 SUPERFAMILY SSF55729 16 113 1.21E-15 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS29990 a59648b538fef37f6a4af5944c525845 279 SUPERFAMILY SSF55729 121 273 1.95E-22 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS29990 a59648b538fef37f6a4af5944c525845 279 Gene3D G3DSA:3.40.630.30 129 272 5.1E-26 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS29990 a59648b538fef37f6a4af5944c525845 279 Gene3D G3DSA:3.40.630.30 18 113 3.6E-15 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS29990 a59648b538fef37f6a4af5944c525845 279 Pfam PF00583 Acetyltransferase (GNAT) family 26 105 3.4E-10 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS29990 a59648b538fef37f6a4af5944c525845 279 Pfam PF00583 Acetyltransferase (GNAT) family 190 269 2.6E-16 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS07610 f68dcb14b842c742edcb62ba7a20fc85 875 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 161 260 1.6E-8 T 09-03-2017 IPR000014 PAS domain TK78_RS07610 f68dcb14b842c742edcb62ba7a20fc85 875 Gene3D G3DSA:3.30.450.40 297 439 5.4E-20 T 09-03-2017 IPR029016 GAF domain-like TK78_RS07610 f68dcb14b842c742edcb62ba7a20fc85 875 SMART SM00331 652 869 1.9E-64 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS07610 f68dcb14b842c742edcb62ba7a20fc85 875 Pfam PF13581 Histidine kinase-like ATPase domain 19 130 1.2E-7 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS07610 f68dcb14b842c742edcb62ba7a20fc85 875 Gene3D G3DSA:3.30.450.20 160 260 4.6E-10 T 09-03-2017 TK78_RS07610 f68dcb14b842c742edcb62ba7a20fc85 875 SUPERFAMILY SSF55785 161 255 7.33E-14 T 09-03-2017 IPR000014 PAS domain TK78_RS07610 f68dcb14b842c742edcb62ba7a20fc85 875 SMART SM00065 298 442 1.1E-12 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS07610 f68dcb14b842c742edcb62ba7a20fc85 875 SMART SM00065 463 631 0.083 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS07610 f68dcb14b842c742edcb62ba7a20fc85 875 Pfam PF13185 GAF domain 298 433 3.1E-11 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS07610 f68dcb14b842c742edcb62ba7a20fc85 875 Pfam PF13185 GAF domain 524 622 8.2E-7 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS07610 f68dcb14b842c742edcb62ba7a20fc85 875 SUPERFAMILY SSF81606 661 869 7.06E-6 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS07610 f68dcb14b842c742edcb62ba7a20fc85 875 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 679 869 1.6E-41 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS07610 f68dcb14b842c742edcb62ba7a20fc85 875 Gene3D G3DSA:3.30.450.40 452 629 1.2E-21 T 09-03-2017 IPR029016 GAF domain-like TK78_RS07610 f68dcb14b842c742edcb62ba7a20fc85 875 SUPERFAMILY SSF55781 299 437 7.85E-19 T 09-03-2017 IPR029016 GAF domain-like TK78_RS07610 f68dcb14b842c742edcb62ba7a20fc85 875 SUPERFAMILY SSF55781 448 629 1.0E-11 T 09-03-2017 IPR029016 GAF domain-like TK78_RS07610 f68dcb14b842c742edcb62ba7a20fc85 875 Pfam PF08448 PAS fold 161 260 3.5E-5 T 09-03-2017 IPR013656 PAS fold-4 TK78_RS11245 d8de7a4540c7d73f737c2eb1bb0635a1 855 SMART SM00331 466 711 2.2E-42 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS11245 d8de7a4540c7d73f737c2eb1bb0635a1 855 Pfam PF13581 Histidine kinase-like ATPase domain 725 832 1.6E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS11245 d8de7a4540c7d73f737c2eb1bb0635a1 855 SMART SM00065 256 448 0.0015 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS11245 d8de7a4540c7d73f737c2eb1bb0635a1 855 Pfam PF08448 PAS fold 17 122 3.1E-7 T 09-03-2017 IPR013656 PAS fold-4 TK78_RS11245 d8de7a4540c7d73f737c2eb1bb0635a1 855 Pfam PF08448 PAS fold 135 245 3.1E-21 T 09-03-2017 IPR013656 PAS fold-4 TK78_RS11245 d8de7a4540c7d73f737c2eb1bb0635a1 855 SMART SM00091 128 194 0.005 T 09-03-2017 IPR000014 PAS domain TK78_RS11245 d8de7a4540c7d73f737c2eb1bb0635a1 855 SMART SM00091 5 72 0.1 T 09-03-2017 IPR000014 PAS domain TK78_RS11245 d8de7a4540c7d73f737c2eb1bb0635a1 855 SUPERFAMILY SSF55781 359 451 1.09E-11 T 09-03-2017 IPR029016 GAF domain-like TK78_RS11245 d8de7a4540c7d73f737c2eb1bb0635a1 855 Pfam PF01590 GAF domain 370 438 3.4E-7 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS11245 d8de7a4540c7d73f737c2eb1bb0635a1 855 Gene3D G3DSA:3.30.450.40 261 446 1.5E-33 T 09-03-2017 IPR029016 GAF domain-like TK78_RS11245 d8de7a4540c7d73f737c2eb1bb0635a1 855 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 495 711 1.2E-49 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS11245 d8de7a4540c7d73f737c2eb1bb0635a1 855 SUPERFAMILY SSF55785 120 242 3.77E-14 T 09-03-2017 IPR000014 PAS domain TK78_RS11245 d8de7a4540c7d73f737c2eb1bb0635a1 855 SUPERFAMILY SSF55785 19 127 2.51E-9 T 09-03-2017 IPR000014 PAS domain TK78_RS11245 d8de7a4540c7d73f737c2eb1bb0635a1 855 Gene3D G3DSA:3.30.450.20 121 244 4.0E-18 T 09-03-2017 TK78_RS11245 d8de7a4540c7d73f737c2eb1bb0635a1 855 Gene3D G3DSA:3.30.450.20 9 117 1.2E-10 T 09-03-2017 TK78_RS11245 d8de7a4540c7d73f737c2eb1bb0635a1 855 SUPERFAMILY SSF81606 568 712 1.36E-7 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS11245 d8de7a4540c7d73f737c2eb1bb0635a1 855 SUPERFAMILY SSF81606 482 536 1.36E-7 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS11245 d8de7a4540c7d73f737c2eb1bb0635a1 855 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 132 250 1.5E-8 T 09-03-2017 IPR000014 PAS domain TK78_RS11245 d8de7a4540c7d73f737c2eb1bb0635a1 855 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 9 125 8.1E-9 T 09-03-2017 IPR000014 PAS domain TK78_RS11245 d8de7a4540c7d73f737c2eb1bb0635a1 855 SUPERFAMILY SSF55874 752 835 4.07E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS17065 0d2871c847152858cf4d66cafe2c7ed0 568 Pfam PF13185 GAF domain 216 349 1.0E-14 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS17065 0d2871c847152858cf4d66cafe2c7ed0 568 Pfam PF13185 GAF domain 46 185 1.3E-20 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS17065 0d2871c847152858cf4d66cafe2c7ed0 568 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 475 530 6.9E-5 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS17065 0d2871c847152858cf4d66cafe2c7ed0 568 Pfam PF07730 Histidine kinase 367 428 3.7E-11 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS17065 0d2871c847152858cf4d66cafe2c7ed0 568 SMART SM00065 46 195 1.9E-20 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS17065 0d2871c847152858cf4d66cafe2c7ed0 568 SMART SM00065 216 359 2.7E-10 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS17065 0d2871c847152858cf4d66cafe2c7ed0 568 SUPERFAMILY SSF55781 32 202 2.62E-34 T 09-03-2017 IPR029016 GAF domain-like TK78_RS17065 0d2871c847152858cf4d66cafe2c7ed0 568 Gene3D G3DSA:3.30.565.10 474 567 7.0E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS17065 0d2871c847152858cf4d66cafe2c7ed0 568 SUPERFAMILY SSF55781 216 362 1.57E-19 T 09-03-2017 IPR029016 GAF domain-like TK78_RS17065 0d2871c847152858cf4d66cafe2c7ed0 568 SMART SM00387 471 568 6.7E-8 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS17065 0d2871c847152858cf4d66cafe2c7ed0 568 Gene3D G3DSA:3.30.450.40 207 352 4.3E-21 T 09-03-2017 IPR029016 GAF domain-like TK78_RS17065 0d2871c847152858cf4d66cafe2c7ed0 568 Gene3D G3DSA:3.30.450.40 35 192 9.2E-32 T 09-03-2017 IPR029016 GAF domain-like TK78_RS17065 0d2871c847152858cf4d66cafe2c7ed0 568 SUPERFAMILY SSF55874 476 567 4.32E-11 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09345 8d2c19f6bd3152f9c1870e4945810061 568 Pfam PF16657 Maltogenic Amylase, C-terminal domain 481 558 8.8E-25 T 09-03-2017 IPR032091 Maltogenic Amylase, C-terminal TK78_RS09345 8d2c19f6bd3152f9c1870e4945810061 568 SUPERFAMILY SSF51445 34 481 1.48E-134 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS09345 8d2c19f6bd3152f9c1870e4945810061 568 SUPERFAMILY SSF51011 485 561 3.98E-17 T 09-03-2017 TK78_RS09345 8d2c19f6bd3152f9c1870e4945810061 568 SMART SM00642 31 433 1.2E-119 T 09-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 TK78_RS09345 8d2c19f6bd3152f9c1870e4945810061 568 Gene3D G3DSA:3.20.20.80 198 427 3.0E-113 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS09345 8d2c19f6bd3152f9c1870e4945810061 568 Gene3D G3DSA:3.20.20.80 460 474 3.0E-113 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS09345 8d2c19f6bd3152f9c1870e4945810061 568 Gene3D G3DSA:3.20.20.80 25 122 3.0E-113 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS09345 8d2c19f6bd3152f9c1870e4945810061 568 Gene3D G3DSA:2.60.40.1180 481 561 8.5E-14 T 09-03-2017 IPR013780 Glycosyl hydrolase, all-beta TK78_RS09345 8d2c19f6bd3152f9c1870e4945810061 568 Gene3D G3DSA:3.90.400.10 123 190 2.9E-24 T 09-03-2017 TK78_RS09345 8d2c19f6bd3152f9c1870e4945810061 568 TIGRFAM TIGR02456 treS_nterm: trehalose synthase 23 561 6.1E-303 T 09-03-2017 IPR012810 Trehalose synthase/alpha-amylase, N-terminal GO:0003824|GO:0005975 KEGG: 00500+5.4.99.16|MetaCyc: PWY-2622 TK78_RS09345 8d2c19f6bd3152f9c1870e4945810061 568 Pfam PF00128 Alpha amylase, catalytic domain 46 402 3.1E-79 T 09-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 TK78_RS04265 421d87e11f20b9bde30c877fbcba1237 417 Gene3D G3DSA:3.40.50.2300 47 243 1.5E-34 T 09-03-2017 TK78_RS04265 421d87e11f20b9bde30c877fbcba1237 417 SUPERFAMILY SSF53822 47 391 1.15E-54 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS04265 421d87e11f20b9bde30c877fbcba1237 417 Pfam PF13458 Periplasmic binding protein 47 391 3.3E-60 T 09-03-2017 IPR028081 Leucine-binding protein domain TK78_RS04985 241070b96c53f17d6505dbfee8b44dd1 307 PIRSF PIRSF000241 1 300 8.3E-110 T 09-03-2017 IPR002042 Uricase KEGG: 00230+1.7.3.3|KEGG: 00232+1.7.3.3|MetaCyc: PWY-5691 TK78_RS04985 241070b96c53f17d6505dbfee8b44dd1 307 SUPERFAMILY SSF55620 4 137 1.33E-40 T 09-03-2017 TK78_RS04985 241070b96c53f17d6505dbfee8b44dd1 307 Gene3D G3DSA:3.10.270.10 3 298 4.1E-113 T 09-03-2017 TK78_RS04985 241070b96c53f17d6505dbfee8b44dd1 307 ProDom PD003367 URICASE OXIDOREDUCTASE URATE OXIDASE METABOLISM PURINE PEROXISOME ACETYLATION II DIRECT 186 293 2.0E-53 T 09-03-2017 TK78_RS04985 241070b96c53f17d6505dbfee8b44dd1 307 SUPERFAMILY SSF55620 147 298 1.5E-57 T 09-03-2017 TK78_RS04985 241070b96c53f17d6505dbfee8b44dd1 307 PRINTS PR00093 Uricase signature 86 99 4.9E-18 T 09-03-2017 IPR002042 Uricase KEGG: 00230+1.7.3.3|KEGG: 00232+1.7.3.3|MetaCyc: PWY-5691 TK78_RS04985 241070b96c53f17d6505dbfee8b44dd1 307 PRINTS PR00093 Uricase signature 172 184 4.9E-18 T 09-03-2017 IPR002042 Uricase KEGG: 00230+1.7.3.3|KEGG: 00232+1.7.3.3|MetaCyc: PWY-5691 TK78_RS04985 241070b96c53f17d6505dbfee8b44dd1 307 PRINTS PR00093 Uricase signature 50 64 4.9E-18 T 09-03-2017 IPR002042 Uricase KEGG: 00230+1.7.3.3|KEGG: 00232+1.7.3.3|MetaCyc: PWY-5691 TK78_RS04985 241070b96c53f17d6505dbfee8b44dd1 307 PRINTS PR00093 Uricase signature 11 22 4.9E-18 T 09-03-2017 IPR002042 Uricase KEGG: 00230+1.7.3.3|KEGG: 00232+1.7.3.3|MetaCyc: PWY-5691 TK78_RS04985 241070b96c53f17d6505dbfee8b44dd1 307 PRINTS PR00093 Uricase signature 156 172 4.9E-18 T 09-03-2017 IPR002042 Uricase KEGG: 00230+1.7.3.3|KEGG: 00232+1.7.3.3|MetaCyc: PWY-5691 TK78_RS04985 241070b96c53f17d6505dbfee8b44dd1 307 Pfam PF01014 Uricase 151 288 3.1E-33 T 09-03-2017 IPR002042 Uricase KEGG: 00230+1.7.3.3|KEGG: 00232+1.7.3.3|MetaCyc: PWY-5691 TK78_RS04985 241070b96c53f17d6505dbfee8b44dd1 307 Pfam PF01014 Uricase 9 140 3.0E-17 T 09-03-2017 IPR002042 Uricase KEGG: 00230+1.7.3.3|KEGG: 00232+1.7.3.3|MetaCyc: PWY-5691 TK78_RS04985 241070b96c53f17d6505dbfee8b44dd1 307 TIGRFAM TIGR03383 urate_oxi: urate oxidase 5 293 2.0E-109 T 09-03-2017 IPR002042 Uricase KEGG: 00230+1.7.3.3|KEGG: 00232+1.7.3.3|MetaCyc: PWY-5691 TK78_RS17655 fb01a1f81d6dd317a5b3fb39c0915413 395 Pfam PF03454 MoeA C-terminal region (domain IV) 313 381 2.7E-9 T 09-03-2017 IPR005111 MoeA, C-terminal, domain IV GO:0032324 MetaCyc: PWY-6823|Reactome: R-HSA-947581 TK78_RS17655 fb01a1f81d6dd317a5b3fb39c0915413 395 SUPERFAMILY SSF63882 7 158 1.57E-34 T 09-03-2017 IPR005110 MoeA, N-terminal and linker domain GO:0032324 MetaCyc: PWY-6823|Reactome: R-HSA-947581 TK78_RS17655 fb01a1f81d6dd317a5b3fb39c0915413 395 Pfam PF00994 Probable molybdopterin binding domain 163 297 9.9E-22 T 09-03-2017 IPR001453 MoaB/Mog domain TK78_RS17655 fb01a1f81d6dd317a5b3fb39c0915413 395 Gene3D G3DSA:3.90.105.10 116 144 1.7E-13 T 09-03-2017 TK78_RS17655 fb01a1f81d6dd317a5b3fb39c0915413 395 SUPERFAMILY SSF63867 309 381 2.09E-6 T 09-03-2017 IPR005111 MoeA, C-terminal, domain IV GO:0032324 MetaCyc: PWY-6823|Reactome: R-HSA-947581 TK78_RS17655 fb01a1f81d6dd317a5b3fb39c0915413 395 Pfam PF03453 MoeA N-terminal region (domain I and II) 11 149 5.7E-30 T 09-03-2017 IPR005110 MoeA, N-terminal and linker domain GO:0032324 MetaCyc: PWY-6823|Reactome: R-HSA-947581 TK78_RS17655 fb01a1f81d6dd317a5b3fb39c0915413 395 SMART SM00852 162 299 1.1E-23 T 09-03-2017 IPR001453 MoaB/Mog domain TK78_RS17655 fb01a1f81d6dd317a5b3fb39c0915413 395 Gene3D G3DSA:2.170.190.11 33 115 3.7E-19 T 09-03-2017 TK78_RS17655 fb01a1f81d6dd317a5b3fb39c0915413 395 Gene3D G3DSA:2.40.340.10 311 381 6.5E-5 T 09-03-2017 IPR005111 MoeA, C-terminal, domain IV GO:0032324 MetaCyc: PWY-6823|Reactome: R-HSA-947581 TK78_RS17655 fb01a1f81d6dd317a5b3fb39c0915413 395 SUPERFAMILY SSF53218 159 302 1.7E-27 T 09-03-2017 IPR001453 MoaB/Mog domain TK78_RS17655 fb01a1f81d6dd317a5b3fb39c0915413 395 Gene3D G3DSA:3.40.980.10 145 310 1.4E-41 T 09-03-2017 IPR001453 MoaB/Mog domain TK78_RS11395 2fae1ab07aaaac3ece64f7c2e99cbb97 556 ProSitePatterns PS00163 Fumarate lyases signature. 457 466 - T 09-03-2017 IPR020557 Fumarate lyase, conserved site GO:0003824 TK78_RS11395 2fae1ab07aaaac3ece64f7c2e99cbb97 556 TIGRFAM TIGR00723 ttdB_fumA_fumB: hydrolyase, tartrate beta subunit/fumarate domain protein, Fe-S type 374 537 2.4E-58 T 09-03-2017 IPR004647 Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain GO:0016836 TK78_RS11395 2fae1ab07aaaac3ece64f7c2e99cbb97 556 PIRSF PIRSF001394 28 551 2.2E-227 T 09-03-2017 IPR011167 Iron-dependent fumarate hydratase GO:0004333|GO:0006091 KEGG: 00020+4.2.1.2|KEGG: 00620+4.2.1.2|KEGG: 00720+4.2.1.2|MetaCyc: PWY-5392|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7384 TK78_RS11395 2fae1ab07aaaac3ece64f7c2e99cbb97 556 SUPERFAMILY SSF117457 362 536 3.4E-62 T 09-03-2017 IPR004647 Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain GO:0016836 TK78_RS11395 2fae1ab07aaaac3ece64f7c2e99cbb97 556 Gene3D G3DSA:3.20.130.10 353 537 3.5E-75 T 09-03-2017 IPR004647 Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain GO:0016836 TK78_RS11395 2fae1ab07aaaac3ece64f7c2e99cbb97 556 TIGRFAM TIGR00722 ttdA_fumA_fumB: hydrolyase, tartrate alpha subunit/fumarate domain protein, Fe-S type 53 326 3.3E-34 T 09-03-2017 IPR004646 Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain GO:0016829 TK78_RS11395 2fae1ab07aaaac3ece64f7c2e99cbb97 556 Pfam PF05681 Fumarate hydratase (Fumerase) 48 324 5.7E-90 T 09-03-2017 IPR004646 Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain GO:0016829 TK78_RS11395 2fae1ab07aaaac3ece64f7c2e99cbb97 556 Pfam PF05683 Fumarase C-terminus 330 538 3.4E-92 T 09-03-2017 IPR004647 Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain GO:0016836 TK78_RS02315 22d8edb2e29d6ecba0ecd912e41c2abd 455 SUPERFAMILY SSF52777 7 178 1.22E-6 T 09-03-2017 TK78_RS02315 22d8edb2e29d6ecba0ecd912e41c2abd 455 Pfam PF06974 Protein of unknown function (DUF1298) 297 442 1.4E-22 T 09-03-2017 IPR009721 O-acyltransferase WSD1, C-terminal GO:0004144 KEGG: 00073+2.3.1.20|KEGG: 00561+2.3.1.20 TK78_RS02315 22d8edb2e29d6ecba0ecd912e41c2abd 455 Pfam PF03007 Wax ester synthase-like Acyl-CoA acyltransferase domain 6 254 9.2E-43 T 09-03-2017 IPR004255 O-acyltransferase, WSD1, N-terminal GO:0004144|GO:0045017 KEGG: 00073+2.3.1.20|KEGG: 00561+2.3.1.20 TK78_RS02315 22d8edb2e29d6ecba0ecd912e41c2abd 455 SUPERFAMILY SSF52777 217 427 1.33E-6 T 09-03-2017 TK78_RS02315 22d8edb2e29d6ecba0ecd912e41c2abd 455 TIGRFAM TIGR02946 acyl_WS_DGAT: acyltransferase, WS/DGAT/MGAT 6 445 4.9E-108 T 09-03-2017 IPR014292 Acyltransferase, WS/DGAT/MGAT GO:0016746|GO:0045017 KEGG: 00073+2.3.1.20|KEGG: 00561+2.3.1.20 TK78_RS07000 3a0b6ea0551aba82cc6d07c2ebad92f4 438 TIGRFAM TIGR04515 P450_rel_GT_act: P450-derived glycosyltranferase activator 16 434 2.0E-136 T 09-03-2017 IPR030958 P450-derived glycosyltranferase activator TK78_RS07000 3a0b6ea0551aba82cc6d07c2ebad92f4 438 Pfam PF00067 Cytochrome P450 314 373 3.2E-8 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS07000 3a0b6ea0551aba82cc6d07c2ebad92f4 438 Gene3D G3DSA:1.10.630.10 35 434 6.5E-49 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS07000 3a0b6ea0551aba82cc6d07c2ebad92f4 438 SUPERFAMILY SSF48264 28 389 2.49E-37 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS07000 3a0b6ea0551aba82cc6d07c2ebad92f4 438 PRINTS PR00359 B-class P450 signature 358 373 1.2E-19 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS07000 3a0b6ea0551aba82cc6d07c2ebad92f4 438 PRINTS PR00359 B-class P450 signature 166 182 1.2E-19 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS07000 3a0b6ea0551aba82cc6d07c2ebad92f4 438 PRINTS PR00359 B-class P450 signature 313 324 1.2E-19 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS07000 3a0b6ea0551aba82cc6d07c2ebad92f4 438 PRINTS PR00359 B-class P450 signature 183 198 1.2E-19 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS07000 3a0b6ea0551aba82cc6d07c2ebad92f4 438 PRINTS PR00359 B-class P450 signature 330 357 1.2E-19 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS08790 69c5c9f5fb865f140a9bb3dfe3f75e8a 315 Gene3D G3DSA:3.40.50.720 28 116 4.7E-16 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS08790 69c5c9f5fb865f140a9bb3dfe3f75e8a 315 Gene3D G3DSA:3.40.50.720 117 283 6.3E-54 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS08790 69c5c9f5fb865f140a9bb3dfe3f75e8a 315 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 108 280 1.1E-47 T 09-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 TK78_RS08790 69c5c9f5fb865f140a9bb3dfe3f75e8a 315 SUPERFAMILY SSF51735 101 281 3.95E-46 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS08790 69c5c9f5fb865f140a9bb3dfe3f75e8a 315 Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 52 311 5.1E-7 T 09-03-2017 IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0008152|GO:0016616|GO:0051287|GO:0055114 TK78_RS08790 69c5c9f5fb865f140a9bb3dfe3f75e8a 315 ProSitePatterns PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 220 236 - T 09-03-2017 IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site TK78_RS33325 109171a6c084446b1481b681dac3d7c0 407 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 153 169 - T 09-03-2017 IPR018201 Beta-ketoacyl synthase, active site TK78_RS33325 109171a6c084446b1481b681dac3d7c0 407 SMART SM00825 Beta-ketoacyl synthase 6 407 3.8E-14 T 09-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TK78_RS33325 109171a6c084446b1481b681dac3d7c0 407 SUPERFAMILY SSF53901 136 405 1.87E-63 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS33325 109171a6c084446b1481b681dac3d7c0 407 SUPERFAMILY SSF53901 5 104 1.87E-63 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS33325 109171a6c084446b1481b681dac3d7c0 407 Gene3D G3DSA:3.40.47.10 5 255 1.7E-58 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS33325 109171a6c084446b1481b681dac3d7c0 407 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 5 245 1.2E-45 T 09-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal TK78_RS33325 109171a6c084446b1481b681dac3d7c0 407 Gene3D G3DSA:3.40.47.10 262 405 7.6E-49 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS33325 109171a6c084446b1481b681dac3d7c0 407 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 254 364 8.7E-29 T 09-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal TK78_RS32910 c93aac42a9398da079f8c7ffa0d03330 531 TIGRFAM TIGR00546 lnt: apolipoprotein N-acyltransferase 76 468 2.7E-81 T 09-03-2017 IPR004563 Apolipoprotein N-acyltransferase GO:0016021|GO:0016410|GO:0042158 TK78_RS32910 c93aac42a9398da079f8c7ffa0d03330 531 SUPERFAMILY SSF56317 233 500 7.06E-44 T 09-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 TK78_RS32910 c93aac42a9398da079f8c7ffa0d03330 531 Gene3D G3DSA:3.60.110.10 230 494 1.3E-37 T 09-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 TK78_RS32910 c93aac42a9398da079f8c7ffa0d03330 531 Pfam PF00795 Carbon-nitrogen hydrolase 301 487 4.7E-20 T 09-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 TK78_RS32910 c93aac42a9398da079f8c7ffa0d03330 531 Hamap MF_01148 Apolipoprotein N-acyltransferase [lnt]. 22 506 15.374 T 09-03-2017 IPR004563 Apolipoprotein N-acyltransferase GO:0016021|GO:0016410|GO:0042158 TK78_RS12600 4e91e176ace50db9b62dee31dfb81377 231 Gene3D G3DSA:1.10.10.10 138 231 5.2E-36 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS12600 4e91e176ace50db9b62dee31dfb81377 231 Pfam PF00072 Response regulator receiver domain 17 134 1.5E-15 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS12600 4e91e176ace50db9b62dee31dfb81377 231 SMART SM00448 15 134 2.6E-17 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS12600 4e91e176ace50db9b62dee31dfb81377 231 SMART SM00421 168 225 6.0E-26 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS12600 4e91e176ace50db9b62dee31dfb81377 231 Pfam PF00196 Bacterial regulatory proteins, luxR family 170 225 9.1E-21 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS12600 4e91e176ace50db9b62dee31dfb81377 231 Gene3D G3DSA:3.40.50.2300 12 137 8.2E-24 T 09-03-2017 TK78_RS12600 4e91e176ace50db9b62dee31dfb81377 231 ProSitePatterns PS00622 LuxR-type HTH domain signature. 185 212 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS12600 4e91e176ace50db9b62dee31dfb81377 231 SUPERFAMILY SSF52172 14 152 1.17E-21 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS12600 4e91e176ace50db9b62dee31dfb81377 231 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 171 185 9.9E-15 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS12600 4e91e176ace50db9b62dee31dfb81377 231 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 201 213 9.9E-15 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS12600 4e91e176ace50db9b62dee31dfb81377 231 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 185 201 9.9E-15 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS12600 4e91e176ace50db9b62dee31dfb81377 231 SUPERFAMILY SSF46894 161 230 1.97E-23 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS01245 e1bb405a700f85f98b927406f1ab254d 291 Gene3D G3DSA:3.40.50.1820 2 268 1.9E-53 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS01245 e1bb405a700f85f98b927406f1ab254d 291 Pfam PF12697 Alpha/beta hydrolase family 23 261 5.0E-17 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS01245 e1bb405a700f85f98b927406f1ab254d 291 PRINTS PR00412 Epoxide hydrolase signature 243 265 3.9E-8 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS01245 e1bb405a700f85f98b927406f1ab254d 291 PRINTS PR00412 Epoxide hydrolase signature 48 63 3.9E-8 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS01245 e1bb405a700f85f98b927406f1ab254d 291 PRINTS PR00412 Epoxide hydrolase signature 106 119 3.9E-8 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS01245 e1bb405a700f85f98b927406f1ab254d 291 PRINTS PR00412 Epoxide hydrolase signature 210 226 3.9E-8 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS01245 e1bb405a700f85f98b927406f1ab254d 291 SUPERFAMILY SSF53474 2 267 2.95E-54 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS32450 4008488d27afa44ed5340eaeb3e214e6 1430 Gene3D G3DSA:2.60.120.260 727 853 2.2E-8 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS32450 4008488d27afa44ed5340eaeb3e214e6 1430 Pfam PF11847 Domain of unknown function (DUF3367) 45 704 6.4E-218 T 09-03-2017 IPR021798 Protein of unknown function DUF3367 MetaCyc: PWY-6397 TK78_RS32450 4008488d27afa44ed5340eaeb3e214e6 1430 SUPERFAMILY SSF49785 733 847 1.47E-7 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS30410 75cc74e7d398791f6e5b708b913152c2 265 SUPERFAMILY SSF56317 1 263 1.57E-72 T 09-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 TK78_RS30410 75cc74e7d398791f6e5b708b913152c2 265 Gene3D G3DSA:3.60.110.10 2 263 2.1E-74 T 09-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 TK78_RS30410 75cc74e7d398791f6e5b708b913152c2 265 Pfam PF00795 Carbon-nitrogen hydrolase 5 245 3.4E-46 T 09-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 TK78_RS30410 75cc74e7d398791f6e5b708b913152c2 265 ProSitePatterns PS01227 Uncharacterized protein family UPF0012 signature. 143 163 - T 09-03-2017 IPR001110 Uncharacterised protein family UPF0012, conserved site TK78_RS29480 3346173731ec84f681725c366306e44e 194 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 30 190 2.9E-21 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS29480 3346173731ec84f681725c366306e44e 194 SUPERFAMILY SSF88946 13 104 2.55E-19 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS29480 3346173731ec84f681725c366306e44e 194 SUPERFAMILY SSF88659 125 190 1.11E-14 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS29480 3346173731ec84f681725c366306e44e 194 Gene3D G3DSA:1.10.10.10 127 191 3.0E-18 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS29480 3346173731ec84f681725c366306e44e 194 Pfam PF08281 Sigma-70, region 4 133 186 1.3E-12 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS29480 3346173731ec84f681725c366306e44e 194 Gene3D G3DSA:1.10.1740.10 16 120 1.3E-19 T 09-03-2017 TK78_RS29480 3346173731ec84f681725c366306e44e 194 Pfam PF04542 Sigma-70 region 2 36 101 1.0E-13 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS18400 598fc245bb27e3d4b5bcd0dea3d0c164 486 Pfam PF01381 Helix-turn-helix 16 69 7.7E-13 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS18400 598fc245bb27e3d4b5bcd0dea3d0c164 486 Pfam PF06114 Domain of unknown function (DUF955) 192 316 4.1E-20 T 09-03-2017 IPR010359 HTH domain, IrrE-type TK78_RS18400 598fc245bb27e3d4b5bcd0dea3d0c164 486 SMART SM00530 15 70 5.3E-15 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS18400 598fc245bb27e3d4b5bcd0dea3d0c164 486 PIRSF PIRSF019251 5 478 3.1E-184 T 09-03-2017 IPR026281 HTH-type transcriptional regulator RamB GO:0006355 TK78_RS18400 598fc245bb27e3d4b5bcd0dea3d0c164 486 Gene3D G3DSA:1.10.260.40 6 77 2.7E-17 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS18400 598fc245bb27e3d4b5bcd0dea3d0c164 486 SUPERFAMILY SSF47413 13 72 2.95E-14 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS18400 598fc245bb27e3d4b5bcd0dea3d0c164 486 Pfam PF09856 Predicted transcriptional regulator (DUF2083) 317 473 4.1E-69 T 09-03-2017 IPR018653 Domain of unknown function DUF2083,transcriptional regulator TK78_RS29580 0685894cae64ccde1a1fe78e9385feca 238 Gene3D G3DSA:3.30.110.10 98 190 6.6E-38 T 09-03-2017 IPR019815 Translation initiation factor 3, C-terminal GO:0006413 Reactome: R-HSA-5368286 TK78_RS29580 0685894cae64ccde1a1fe78e9385feca 238 Gene3D G3DSA:3.10.20.80 22 97 1.8E-34 T 09-03-2017 IPR019814 Translation initiation factor 3, N-terminal GO:0003743|GO:0006413 Reactome: R-HSA-5368286 TK78_RS29580 0685894cae64ccde1a1fe78e9385feca 238 TIGRFAM TIGR00168 infC: translation initiation factor IF-3 26 189 1.4E-59 T 09-03-2017 IPR001288 Translation initiation factor 3 GO:0003743|GO:0006413 Reactome: R-HSA-5368286 TK78_RS29580 0685894cae64ccde1a1fe78e9385feca 238 Pfam PF00707 Translation initiation factor IF-3, C-terminal domain 103 186 2.4E-33 T 09-03-2017 IPR019815 Translation initiation factor 3, C-terminal GO:0006413 Reactome: R-HSA-5368286 TK78_RS29580 0685894cae64ccde1a1fe78e9385feca 238 SUPERFAMILY SSF55200 104 188 1.96E-31 T 09-03-2017 IPR019815 Translation initiation factor 3, C-terminal GO:0006413 Reactome: R-HSA-5368286 TK78_RS29580 0685894cae64ccde1a1fe78e9385feca 238 Hamap MF_00080 Translation initiation factor IF-3 [infC]. 20 189 29.416 T 09-03-2017 IPR001288 Translation initiation factor 3 GO:0003743|GO:0006413 Reactome: R-HSA-5368286 TK78_RS29580 0685894cae64ccde1a1fe78e9385feca 238 Pfam PF05198 Translation initiation factor IF-3, N-terminal domain 26 95 2.3E-28 T 09-03-2017 IPR019814 Translation initiation factor 3, N-terminal GO:0003743|GO:0006413 Reactome: R-HSA-5368286 TK78_RS29580 0685894cae64ccde1a1fe78e9385feca 238 SUPERFAMILY SSF54364 24 97 1.11E-27 T 09-03-2017 IPR019814 Translation initiation factor 3, N-terminal GO:0003743|GO:0006413 Reactome: R-HSA-5368286 TK78_RS27050 d77eb9d5704ed1458d8e003d96bb3075 347 PIRSF PIRSF002849 2 321 7.3E-131 T 09-03-2017 IPR016366 ATPase chaperone, AAA-type, MoxR, predicted TK78_RS27050 d77eb9d5704ed1458d8e003d96bb3075 347 Gene3D G3DSA:1.10.8.300 209 315 2.3E-36 T 09-03-2017 TK78_RS27050 d77eb9d5704ed1458d8e003d96bb3075 347 Pfam PF07726 ATPase family associated with various cellular activities (AAA) 47 176 4.2E-65 T 09-03-2017 IPR011703 ATPase, AAA-3 GO:0005524|GO:0016887 TK78_RS27050 d77eb9d5704ed1458d8e003d96bb3075 347 Gene3D G3DSA:3.40.50.300 33 193 4.9E-42 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27050 d77eb9d5704ed1458d8e003d96bb3075 347 SUPERFAMILY SSF52540 18 291 7.2E-43 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS00350 eff57743265ce6155212e6da05ccf973 325 Pfam PF05726 Pirin C-terminal cupin domain 196 296 4.6E-18 T 09-03-2017 IPR008778 Pirin, C-terminal domain TK78_RS00350 eff57743265ce6155212e6da05ccf973 325 Gene3D G3DSA:2.60.120.10 26 270 1.1E-60 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS00350 eff57743265ce6155212e6da05ccf973 325 PIRSF PIRSF006232 23 306 4.1E-79 T 09-03-2017 IPR012093 Pirin TK78_RS00350 eff57743265ce6155212e6da05ccf973 325 Pfam PF02678 Pirin 44 144 8.9E-31 T 09-03-2017 IPR003829 Pirin, N-terminal domain TK78_RS00350 eff57743265ce6155212e6da05ccf973 325 SUPERFAMILY SSF51182 41 308 6.39E-71 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS13055 2f3dcd098479669f34c7e27ba178e7e0 219 SUPERFAMILY SSF52540 1 214 5.23E-42 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13055 2f3dcd098479669f34c7e27ba178e7e0 219 Hamap MF_00235 Adenylate kinase [adk]. 1 214 50.531 T 09-03-2017 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|Reactome: R-HSA-499943 TK78_RS13055 2f3dcd098479669f34c7e27ba178e7e0 219 Gene3D G3DSA:3.40.50.300 1 212 6.1E-75 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13055 2f3dcd098479669f34c7e27ba178e7e0 219 TIGRFAM TIGR01351 adk: adenylate kinase 2 213 4.6E-77 T 09-03-2017 IPR006259 Adenylate kinase subfamily GO:0004017|GO:0005524|GO:0016776 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219 TK78_RS13055 2f3dcd098479669f34c7e27ba178e7e0 219 PRINTS PR00094 Adenylate kinase signature 4 17 6.3E-36 T 09-03-2017 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|Reactome: R-HSA-499943 TK78_RS13055 2f3dcd098479669f34c7e27ba178e7e0 219 PRINTS PR00094 Adenylate kinase signature 161 176 6.3E-36 T 09-03-2017 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|Reactome: R-HSA-499943 TK78_RS13055 2f3dcd098479669f34c7e27ba178e7e0 219 PRINTS PR00094 Adenylate kinase signature 32 46 6.3E-36 T 09-03-2017 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|Reactome: R-HSA-499943 TK78_RS13055 2f3dcd098479669f34c7e27ba178e7e0 219 PRINTS PR00094 Adenylate kinase signature 81 97 6.3E-36 T 09-03-2017 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|Reactome: R-HSA-499943 TK78_RS13055 2f3dcd098479669f34c7e27ba178e7e0 219 PRINTS PR00094 Adenylate kinase signature 178 192 6.3E-36 T 09-03-2017 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|Reactome: R-HSA-499943 TK78_RS13055 2f3dcd098479669f34c7e27ba178e7e0 219 Pfam PF05191 Adenylate kinase, active site lid 127 163 4.7E-12 T 09-03-2017 IPR007862 Adenylate kinase, active site lid domain GO:0004017 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219 TK78_RS13055 2f3dcd098479669f34c7e27ba178e7e0 219 Pfam PF00406 Adenylate kinase 5 191 2.6E-59 T 09-03-2017 TK78_RS13055 2f3dcd098479669f34c7e27ba178e7e0 219 ProSitePatterns PS00113 Adenylate kinase signature. 81 92 - T 09-03-2017 TK78_RS15910 fbece34964fd8e80e858f46a5f823a63 288 SUPERFAMILY SSF51055 32 78 1.41E-11 T 09-03-2017 IPR003610 Carbohydrate-binding module family 5/12 GO:0004553|GO:0005576|GO:0005975|GO:0030246 TK78_RS15910 fbece34964fd8e80e858f46a5f823a63 288 Pfam PF02839 Carbohydrate binding domain 36 72 1.2E-9 T 09-03-2017 IPR003610 Carbohydrate-binding module family 5/12 GO:0004553|GO:0005576|GO:0005975|GO:0030246 TK78_RS15910 fbece34964fd8e80e858f46a5f823a63 288 PIRSF PIRSF001060 2 288 4.5E-69 T 09-03-2017 IPR016283 Glycoside hydrolase, family 19 GO:0004568|GO:0005975 KEGG: 00520+3.2.1.14|MetaCyc: PWY-6902 TK78_RS15910 fbece34964fd8e80e858f46a5f823a63 288 Pfam PF00182 Chitinase class I 101 288 2.8E-33 T 09-03-2017 IPR000726 Glycoside hydrolase, family 19, catalytic GO:0004568|GO:0006032|GO:0016998 KEGG: 00520+3.2.1.14|MetaCyc: PWY-6902 TK78_RS15910 fbece34964fd8e80e858f46a5f823a63 288 Gene3D G3DSA:3.30.20.10 153 207 5.4E-21 T 09-03-2017 TK78_RS15910 fbece34964fd8e80e858f46a5f823a63 288 SMART SM00495 33 75 3.6E-6 T 09-03-2017 IPR003610 Carbohydrate-binding module family 5/12 GO:0004553|GO:0005576|GO:0005975|GO:0030246 TK78_RS15910 fbece34964fd8e80e858f46a5f823a63 288 Gene3D G3DSA:1.10.530.10 208 288 1.9E-45 T 09-03-2017 TK78_RS15910 fbece34964fd8e80e858f46a5f823a63 288 Gene3D G3DSA:1.10.530.10 86 144 1.9E-45 T 09-03-2017 TK78_RS15910 fbece34964fd8e80e858f46a5f823a63 288 SUPERFAMILY SSF53955 85 288 5.91E-57 T 09-03-2017 IPR023346 Lysozyme-like domain TK78_RS15910 fbece34964fd8e80e858f46a5f823a63 288 Gene3D G3DSA:2.10.10.20 32 78 4.0E-16 T 09-03-2017 IPR003610 Carbohydrate-binding module family 5/12 GO:0004553|GO:0005576|GO:0005975|GO:0030246 TK78_RS28645 33af7b7903ce4887b2da65673ca6120e 371 Pfam PF01262 Alanine dehydrogenase/PNT, C-terminal domain 141 352 6.1E-80 T 09-03-2017 IPR007698 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain TK78_RS28645 33af7b7903ce4887b2da65673ca6120e 371 Gene3D G3DSA:3.40.50.1770 195 357 9.0E-30 T 09-03-2017 TK78_RS28645 33af7b7903ce4887b2da65673ca6120e 371 SMART SM01002 149 297 2.1E-80 T 09-03-2017 IPR007698 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain TK78_RS28645 33af7b7903ce4887b2da65673ca6120e 371 Gene3D G3DSA:3.50.50.60 178 194 1.5E-4 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS28645 33af7b7903ce4887b2da65673ca6120e 371 Pfam PF05222 Alanine dehydrogenase/PNT, N-terminal domain 4 137 5.5E-48 T 09-03-2017 IPR007886 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal TK78_RS28645 33af7b7903ce4887b2da65673ca6120e 371 PIRSF PIRSF000183 1 371 6.6E-165 T 09-03-2017 IPR008141 Alanine dehydrogenase GO:0000286|GO:0042853 KEGG: 00250+1.4.1.1|KEGG: 00430+1.4.1.1 TK78_RS28645 33af7b7903ce4887b2da65673ca6120e 371 TIGRFAM TIGR00518 alaDH: alanine dehydrogenase 2 367 2.9E-173 T 09-03-2017 IPR008141 Alanine dehydrogenase GO:0000286|GO:0042853 KEGG: 00250+1.4.1.1|KEGG: 00430+1.4.1.1 TK78_RS28645 33af7b7903ce4887b2da65673ca6120e 371 SMART SM01003 4 137 2.7E-80 T 09-03-2017 IPR007886 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal TK78_RS28645 33af7b7903ce4887b2da65673ca6120e 371 Gene3D G3DSA:3.40.50.1770 2 177 7.4E-57 T 09-03-2017 TK78_RS28645 33af7b7903ce4887b2da65673ca6120e 371 SUPERFAMILY SSF52283 305 360 1.45E-66 T 09-03-2017 TK78_RS28645 33af7b7903ce4887b2da65673ca6120e 371 SUPERFAMILY SSF52283 2 137 1.45E-66 T 09-03-2017 TK78_RS28645 33af7b7903ce4887b2da65673ca6120e 371 ProSitePatterns PS00836 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1. 4 30 - T 09-03-2017 IPR008142 Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 GO:0016491|GO:0055114 Reactome: R-HSA-71403 TK78_RS28645 33af7b7903ce4887b2da65673ca6120e 371 SUPERFAMILY SSF51735 137 303 3.6E-48 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS27825 4e84a02870681ba488e95502aa957d8b 1015 Gene3D G3DSA:1.10.8.280 290 412 1.5E-34 T 09-03-2017 TK78_RS27825 4e84a02870681ba488e95502aa957d8b 1015 Pfam PF00005 ABC transporter 629 865 2.4E-10 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS27825 4e84a02870681ba488e95502aa957d8b 1015 TIGRFAM TIGR00630 uvra: excinuclease ABC subunit A 5 930 0.0 T 09-03-2017 IPR004602 UvrABC system subunit A GO:0006289|GO:0009380|GO:0009381 TK78_RS27825 4e84a02870681ba488e95502aa957d8b 1015 SUPERFAMILY SSF52540 620 914 3.08E-51 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27825 4e84a02870681ba488e95502aa957d8b 1015 Gene3D G3DSA:3.40.50.300 6 90 2.8E-55 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27825 4e84a02870681ba488e95502aa957d8b 1015 Gene3D G3DSA:3.40.50.300 484 602 2.8E-55 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27825 4e84a02870681ba488e95502aa957d8b 1015 Gene3D G3DSA:3.40.50.300 826 948 7.1E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27825 4e84a02870681ba488e95502aa957d8b 1015 Gene3D G3DSA:3.40.50.300 617 685 7.1E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27825 4e84a02870681ba488e95502aa957d8b 1015 Gene3D G3DSA:1.20.1580.10 413 483 6.0E-56 T 09-03-2017 TK78_RS27825 4e84a02870681ba488e95502aa957d8b 1015 Gene3D G3DSA:1.20.1580.10 92 130 6.0E-56 T 09-03-2017 TK78_RS27825 4e84a02870681ba488e95502aa957d8b 1015 Gene3D G3DSA:1.20.1580.10 255 288 6.0E-56 T 09-03-2017 TK78_RS27825 4e84a02870681ba488e95502aa957d8b 1015 Hamap MF_00205 UvrABC system protein A [uvrA]. 2 945 22.654 T 09-03-2017 IPR004602 UvrABC system subunit A GO:0006289|GO:0009380|GO:0009381 TK78_RS27825 4e84a02870681ba488e95502aa957d8b 1015 Gene3D G3DSA:1.20.1580.10 699 825 8.2E-55 T 09-03-2017 TK78_RS27825 4e84a02870681ba488e95502aa957d8b 1015 ProSitePatterns PS00211 ABC transporters family signature. 835 849 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS27825 4e84a02870681ba488e95502aa957d8b 1015 Gene3D G3DSA:3.30.1490.20 201 242 5.9E-24 T 09-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 TK78_RS27825 4e84a02870681ba488e95502aa957d8b 1015 Gene3D G3DSA:3.30.1490.20 131 154 5.9E-24 T 09-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 TK78_RS27825 4e84a02870681ba488e95502aa957d8b 1015 SUPERFAMILY SSF52540 10 205 4.42E-44 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27825 4e84a02870681ba488e95502aa957d8b 1015 SUPERFAMILY SSF52540 436 575 4.42E-44 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27825 4e84a02870681ba488e95502aa957d8b 1015 ProSitePatterns PS00211 ABC transporters family signature. 493 507 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS09000 57377519d00d9845dd02b9237e10884f 143 Hamap MF_00101 Holo-[acyl-carrier-protein] synthase [acpS]. 1 122 20.008 T 09-03-2017 IPR002582 Holo-[acyl carrier protein] synthase GO:0000287|GO:0006633|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1 TK78_RS09000 57377519d00d9845dd02b9237e10884f 143 ProDom PD004282 TRANSFERASE SYNTHASE HOLO-ACYL-CARRIER-PROTEIN HOLO-ACP 4'-PHOSPHOPANTETHEINYL FATTY ACID METAL-BINDING MAGNESIUM LIPID 6 121 8.0E-11 T 09-03-2017 IPR004568 Phosphopantetheine-protein transferase domain GO:0000287|GO:0006633|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1 TK78_RS09000 57377519d00d9845dd02b9237e10884f 143 SUPERFAMILY SSF56214 2 121 4.45E-23 T 09-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 TK78_RS09000 57377519d00d9845dd02b9237e10884f 143 TIGRFAM TIGR00556 pantethn_trn: phosphopantetheine--protein transferase domain 2 121 2.8E-18 T 09-03-2017 IPR004568 Phosphopantetheine-protein transferase domain GO:0000287|GO:0006633|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1 TK78_RS09000 57377519d00d9845dd02b9237e10884f 143 Gene3D G3DSA:3.90.470.20 2 121 1.4E-28 T 09-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 TK78_RS09000 57377519d00d9845dd02b9237e10884f 143 Pfam PF01648 4'-phosphopantetheinyl transferase superfamily 3 117 1.8E-15 T 09-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 TK78_RS12970 a9988af2cb46ced6cb6976992136d2d2 1602 SUPERFAMILY SSF48452 553 687 1.18E-9 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS12970 a9988af2cb46ced6cb6976992136d2d2 1602 Gene3D G3DSA:1.25.40.10 1486 1529 1.4E-14 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS12970 a9988af2cb46ced6cb6976992136d2d2 1602 Gene3D G3DSA:1.25.40.10 625 826 1.4E-14 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS12970 a9988af2cb46ced6cb6976992136d2d2 1602 TIGRFAM TIGR04267 mod_HExxH: HEXXH motif domain 956 1358 4.3E-113 T 09-03-2017 IPR026337 HEXXH motif domain TK78_RS12970 a9988af2cb46ced6cb6976992136d2d2 1602 Pfam PF13374 Tetratricopeptide repeat 666 697 0.011 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS12970 a9988af2cb46ced6cb6976992136d2d2 1602 Pfam PF13424 Tetratricopeptide repeat 713 780 1.4E-7 T 09-03-2017 TK78_RS12970 a9988af2cb46ced6cb6976992136d2d2 1602 Pfam PF13424 Tetratricopeptide repeat 793 847 1.0E-7 T 09-03-2017 TK78_RS12970 a9988af2cb46ced6cb6976992136d2d2 1602 SUPERFAMILY SSF48452 744 846 1.49E-9 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS12970 a9988af2cb46ced6cb6976992136d2d2 1602 SUPERFAMILY SSF52540 73 295 5.22E-19 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS12970 a9988af2cb46ced6cb6976992136d2d2 1602 PRINTS PR00364 Disease resistance protein signature 176 190 4.6E-6 T 09-03-2017 TK78_RS12970 a9988af2cb46ced6cb6976992136d2d2 1602 PRINTS PR00364 Disease resistance protein signature 104 119 4.6E-6 T 09-03-2017 TK78_RS12970 a9988af2cb46ced6cb6976992136d2d2 1602 PRINTS PR00364 Disease resistance protein signature 272 286 4.6E-6 T 09-03-2017 TK78_RS19440 f3936036e352ed51787cec636c9b4305 552 SMART SM00065 29 194 0.0041 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS19440 f3936036e352ed51787cec636c9b4305 552 Gene3D G3DSA:3.30.450.20 204 321 3.0E-19 T 09-03-2017 TK78_RS19440 f3936036e352ed51787cec636c9b4305 552 SUPERFAMILY SSF55781 12 191 3.27E-15 T 09-03-2017 IPR029016 GAF domain-like TK78_RS19440 f3936036e352ed51787cec636c9b4305 552 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 208 330 1.3E-14 T 09-03-2017 IPR000014 PAS domain TK78_RS19440 f3936036e352ed51787cec636c9b4305 552 Pfam PF00990 Diguanylate cyclase, GGDEF domain 421 544 3.4E-33 T 09-03-2017 IPR000160 GGDEF domain TK78_RS19440 f3936036e352ed51787cec636c9b4305 552 SUPERFAMILY SSF55073 422 545 3.53E-37 T 09-03-2017 IPR029787 Nucleotide cyclase TK78_RS19440 f3936036e352ed51787cec636c9b4305 552 SMART SM00091 212 282 1.2E-5 T 09-03-2017 IPR000014 PAS domain TK78_RS19440 f3936036e352ed51787cec636c9b4305 552 Gene3D G3DSA:3.30.450.40 10 199 4.3E-15 T 09-03-2017 IPR029016 GAF domain-like TK78_RS19440 f3936036e352ed51787cec636c9b4305 552 SUPERFAMILY SSF55785 200 320 2.09E-17 T 09-03-2017 IPR000014 PAS domain TK78_RS19440 f3936036e352ed51787cec636c9b4305 552 SMART SM00267 324 550 5.1E-31 T 09-03-2017 IPR000160 GGDEF domain TK78_RS19440 f3936036e352ed51787cec636c9b4305 552 Gene3D G3DSA:3.30.70.270 420 545 3.4E-47 T 09-03-2017 TK78_RS19440 f3936036e352ed51787cec636c9b4305 552 Gene3D G3DSA:3.30.70.270 337 362 3.4E-47 T 09-03-2017 TK78_RS19440 f3936036e352ed51787cec636c9b4305 552 SMART SM00086 282 324 0.0025 T 09-03-2017 IPR001610 PAC motif TK78_RS19440 f3936036e352ed51787cec636c9b4305 552 Pfam PF13426 PAS domain 233 321 2.9E-6 T 09-03-2017 IPR000014 PAS domain TK78_RS19440 f3936036e352ed51787cec636c9b4305 552 TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain 421 544 3.5E-30 T 09-03-2017 IPR000160 GGDEF domain TK78_RS27475 b204f2c1d3b00fabd655e6a925bfb7d9 366 SUPERFAMILY SSF51412 305 348 6.87E-61 T 09-03-2017 TK78_RS27475 b204f2c1d3b00fabd655e6a925bfb7d9 366 SUPERFAMILY SSF51412 1 244 6.87E-61 T 09-03-2017 TK78_RS27475 b204f2c1d3b00fabd655e6a925bfb7d9 366 Gene3D G3DSA:3.20.20.70 1 332 7.5E-69 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS27475 b204f2c1d3b00fabd655e6a925bfb7d9 366 Pfam PF03060 Nitronate monooxygenase 3 337 1.3E-89 T 09-03-2017 IPR004136 Nitronate monooxygenase GO:0018580|GO:0055114 KEGG: 00910+1.13.12.16|MetaCyc: PWY-723 TK78_RS23220 11155ac3efc836ae4aad8808c195f97c 345 SUPERFAMILY SSF53822 72 344 1.08E-70 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS23220 11155ac3efc836ae4aad8808c195f97c 345 ProSitePatterns PS00356 LacI-type HTH domain signature. 14 32 - T 09-03-2017 TK78_RS23220 11155ac3efc836ae4aad8808c195f97c 345 SUPERFAMILY SSF47413 11 69 1.38E-17 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS23220 11155ac3efc836ae4aad8808c195f97c 345 Pfam PF13377 Periplasmic binding protein-like domain 182 345 1.2E-40 T 09-03-2017 TK78_RS23220 11155ac3efc836ae4aad8808c195f97c 345 SMART SM00354 11 81 2.6E-30 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS23220 11155ac3efc836ae4aad8808c195f97c 345 Gene3D G3DSA:1.10.260.40 12 63 3.5E-24 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS23220 11155ac3efc836ae4aad8808c195f97c 345 Gene3D G3DSA:3.40.50.2300 64 186 5.1E-36 T 09-03-2017 TK78_RS23220 11155ac3efc836ae4aad8808c195f97c 345 Pfam PF00356 Bacterial regulatory proteins, lacI family 13 58 1.5E-17 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS23220 11155ac3efc836ae4aad8808c195f97c 345 Gene3D G3DSA:3.40.50.2300 187 324 2.9E-54 T 09-03-2017 TK78_RS10610 b18a3172d221b4d5cb4309a0a370b243 1127 Pfam PF13361 UvrD-like helicase C-terminal domain 629 758 6.1E-20 T 09-03-2017 IPR014017 UvrD-like DNA helicase, C-terminal GO:0005524|GO:0016787 TK78_RS10610 b18a3172d221b4d5cb4309a0a370b243 1127 Pfam PF12705 PD-(D/E)XK nuclease superfamily 863 1116 4.2E-40 T 09-03-2017 TK78_RS10610 b18a3172d221b4d5cb4309a0a370b243 1127 SUPERFAMILY SSF52540 554 774 8.0E-97 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10610 b18a3172d221b4d5cb4309a0a370b243 1127 SUPERFAMILY SSF52540 2 243 8.0E-97 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10610 b18a3172d221b4d5cb4309a0a370b243 1127 SUPERFAMILY SSF52540 288 468 8.0E-97 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10610 b18a3172d221b4d5cb4309a0a370b243 1127 Gene3D G3DSA:3.40.50.300 1 131 8.6E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10610 b18a3172d221b4d5cb4309a0a370b243 1127 Gene3D G3DSA:3.40.50.300 285 320 8.6E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10610 b18a3172d221b4d5cb4309a0a370b243 1127 Gene3D G3DSA:3.40.50.300 177 242 8.6E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10610 b18a3172d221b4d5cb4309a0a370b243 1127 Gene3D G3DSA:3.40.50.300 676 775 6.1E-43 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10610 b18a3172d221b4d5cb4309a0a370b243 1127 Gene3D G3DSA:3.40.50.300 333 454 6.1E-43 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10610 b18a3172d221b4d5cb4309a0a370b243 1127 Pfam PF00580 UvrD/REP helicase N-terminal domain 2 243 3.6E-36 T 09-03-2017 IPR014016 UvrD-like Helicase, ATP-binding domain GO:0005524 TK78_RS10610 b18a3172d221b4d5cb4309a0a370b243 1127 Pfam PF00580 UvrD/REP helicase N-terminal domain 287 318 5.1E-6 T 09-03-2017 IPR014016 UvrD-like Helicase, ATP-binding domain GO:0005524 TK78_RS12460 c654fc96766a378307aaddada24a98f7 329 TIGRFAM TIGR01759 MalateDH-SF1: malate dehydrogenase 4 323 1.9E-146 T 09-03-2017 IPR010945 Malate dehydrogenase, type 2 GO:0006108|GO:0016615|GO:0055114 KEGG: 00020+1.1.1.37|KEGG: 00270+1.1.1.37|KEGG: 00620+1.1.1.37|KEGG: 00630+1.1.1.37|KEGG: 00680+1.1.1.37|KEGG: 00710+1.1.1.37|KEGG: 00720+1.1.1.37|MetaCyc: PWY-1622|MetaCyc: PWY-5392|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7115|MetaCyc: PWY-7383 TK78_RS12460 c654fc96766a378307aaddada24a98f7 329 Pfam PF00056 lactate/malate dehydrogenase, NAD binding domain 7 147 1.2E-30 T 09-03-2017 IPR001236 Lactate/malate dehydrogenase, N-terminal GO:0016491|GO:0055114 TK78_RS12460 c654fc96766a378307aaddada24a98f7 329 ProSitePatterns PS00068 Malate dehydrogenase active site signature. 156 168 - T 09-03-2017 IPR001252 Malate dehydrogenase, active site GO:0006108|GO:0016615|GO:0055114 KEGG: 00020+1.1.1.37|KEGG: 00270+1.1.1.37|KEGG: 00620+1.1.1.37|KEGG: 00630+1.1.1.37|KEGG: 00680+1.1.1.37|KEGG: 00710+1.1.1.37|KEGG: 00720+1.1.1.37|MetaCyc: PWY-1622|MetaCyc: PWY-5392|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7115|MetaCyc: PWY-7383|Reactome: R-HSA-70263 TK78_RS12460 c654fc96766a378307aaddada24a98f7 329 Gene3D G3DSA:3.40.50.720 5 154 5.9E-51 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS12460 c654fc96766a378307aaddada24a98f7 329 PIRSF PIRSF000102 2 328 7.3E-59 T 09-03-2017 IPR001557 L-lactate/malate dehydrogenase GO:0016616|GO:0019752|GO:0055114 TK78_RS12460 c654fc96766a378307aaddada24a98f7 329 Gene3D G3DSA:3.90.110.10 156 326 5.3E-76 T 09-03-2017 IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal GO:0003824|GO:0005975|GO:0016616|GO:0055114 TK78_RS12460 c654fc96766a378307aaddada24a98f7 329 SUPERFAMILY SSF56327 157 325 6.49E-60 T 09-03-2017 IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal GO:0003824|GO:0005975|GO:0016616|GO:0055114 TK78_RS12460 c654fc96766a378307aaddada24a98f7 329 Hamap MF_01517 Malate dehydrogenase [mdh]. 2 327 57.128 T 09-03-2017 IPR010945 Malate dehydrogenase, type 2 GO:0006108|GO:0016615|GO:0055114 KEGG: 00020+1.1.1.37|KEGG: 00270+1.1.1.37|KEGG: 00620+1.1.1.37|KEGG: 00630+1.1.1.37|KEGG: 00680+1.1.1.37|KEGG: 00710+1.1.1.37|KEGG: 00720+1.1.1.37|MetaCyc: PWY-1622|MetaCyc: PWY-5392|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7115|MetaCyc: PWY-7383 TK78_RS12460 c654fc96766a378307aaddada24a98f7 329 SUPERFAMILY SSF51735 4 156 1.16E-40 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS12460 c654fc96766a378307aaddada24a98f7 329 Pfam PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 157 323 6.7E-34 T 09-03-2017 IPR022383 Lactate/malate dehydrogenase, C-terminal GO:0016616|GO:0055114 TK78_RS32355 767147639e2b1e8931efeafefd49b21b 842 SMART SM01086 732 821 4.8E-31 T 09-03-2017 IPR019489 Clp ATPase, C-terminal TK78_RS32355 767147639e2b1e8931efeafefd49b21b 842 SMART SM00382 565 714 1.2E-12 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS32355 767147639e2b1e8931efeafefd49b21b 842 SMART SM00382 231 378 7.0E-13 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS32355 767147639e2b1e8931efeafefd49b21b 842 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 56 103 4.7E-7 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS32355 767147639e2b1e8931efeafefd49b21b 842 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 127 175 1.4E-6 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS32355 767147639e2b1e8931efeafefd49b21b 842 Gene3D G3DSA:3.40.50.300 519 741 7.2E-60 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS32355 767147639e2b1e8931efeafefd49b21b 842 Gene3D G3DSA:1.10.8.60 377 461 1.1E-32 T 09-03-2017 TK78_RS32355 767147639e2b1e8931efeafefd49b21b 842 SUPERFAMILY SSF52540 514 816 4.48E-80 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS32355 767147639e2b1e8931efeafefd49b21b 842 Pfam PF02151 UvrB/uvrC motif 451 483 2.1E-5 T 09-03-2017 IPR001943 UVR domain GO:0005515 TK78_RS32355 767147639e2b1e8931efeafefd49b21b 842 Gene3D G3DSA:1.10.8.60 742 825 1.6E-27 T 09-03-2017 TK78_RS32355 767147639e2b1e8931efeafefd49b21b 842 Gene3D G3DSA:1.10.1780.10 43 175 2.4E-24 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS32355 767147639e2b1e8931efeafefd49b21b 842 ProSitePatterns PS00871 Chaperonins clpA/B signature 2. 599 617 - T 09-03-2017 IPR028299 ClpA/B, conserved site 2 TK78_RS32355 767147639e2b1e8931efeafefd49b21b 842 Pfam PF10431 C-terminal, D2-small domain, of ClpB protein 732 811 2.5E-22 T 09-03-2017 IPR019489 Clp ATPase, C-terminal TK78_RS32355 767147639e2b1e8931efeafefd49b21b 842 SUPERFAMILY SSF81923 43 179 1.14E-16 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS32355 767147639e2b1e8931efeafefd49b21b 842 Pfam PF07724 AAA domain (Cdc48 subfamily) 564 726 1.5E-53 T 09-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 TK78_RS32355 767147639e2b1e8931efeafefd49b21b 842 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 614 632 3.3E-40 T 09-03-2017 IPR001270 ClpA/B family GO:0005524 TK78_RS32355 767147639e2b1e8931efeafefd49b21b 842 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 676 690 3.3E-40 T 09-03-2017 IPR001270 ClpA/B family GO:0005524 TK78_RS32355 767147639e2b1e8931efeafefd49b21b 842 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 569 587 3.3E-40 T 09-03-2017 IPR001270 ClpA/B family GO:0005524 TK78_RS32355 767147639e2b1e8931efeafefd49b21b 842 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 643 661 3.3E-40 T 09-03-2017 IPR001270 ClpA/B family GO:0005524 TK78_RS32355 767147639e2b1e8931efeafefd49b21b 842 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 236 367 2.1E-13 T 09-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 TK78_RS32355 767147639e2b1e8931efeafefd49b21b 842 Gene3D G3DSA:3.40.50.300 192 376 2.2E-48 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS32355 767147639e2b1e8931efeafefd49b21b 842 ProSitePatterns PS00870 Chaperonins clpA/B signature 1. 328 340 - T 09-03-2017 IPR018368 ClpA/B, conserved site 1 GO:0005524 TK78_RS32355 767147639e2b1e8931efeafefd49b21b 842 SUPERFAMILY SSF52540 194 461 1.29E-72 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS21200 1c974bd53e54b414d10e4c991a200b57 291 SUPERFAMILY SSF53335 24 284 1.77E-63 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS21200 1c974bd53e54b414d10e4c991a200b57 291 TIGRFAM TIGR00755 ksgA: ribosomal RNA small subunit methyltransferase A 24 283 1.1E-70 T 09-03-2017 IPR011530 Ribosomal RNA adenine dimethylase GO:0000179|GO:0006364 TK78_RS21200 1c974bd53e54b414d10e4c991a200b57 291 Pfam PF00398 Ribosomal RNA adenine dimethylase 28 283 2.2E-43 T 09-03-2017 IPR001737 Ribosomal RNA adenine methyltransferase KsgA/Erm TK78_RS21200 1c974bd53e54b414d10e4c991a200b57 291 Gene3D G3DSA:1.10.8.100 222 284 1.7E-21 T 09-03-2017 IPR023165 rRNA adenine dimethylase-like Reactome: R-HSA-2151201 TK78_RS21200 1c974bd53e54b414d10e4c991a200b57 291 ProSitePatterns PS01131 Ribosomal RNA adenine dimethylases signature. 56 83 - T 09-03-2017 IPR020596 Ribosomal RNA adenine methylase transferase, conserved site GO:0000154|GO:0000179|GO:0008649 TK78_RS21200 1c974bd53e54b414d10e4c991a200b57 291 SMART SM00650 40 214 7.1E-68 T 09-03-2017 IPR020598 Ribosomal RNA adenine methylase transferase, N-terminal GO:0000154|GO:0000179|GO:0008649 TK78_RS21200 1c974bd53e54b414d10e4c991a200b57 291 Gene3D G3DSA:3.40.50.150 11 215 2.3E-65 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS21200 1c974bd53e54b414d10e4c991a200b57 291 Hamap MF_00607 Ribosomal RNA small subunit methyltransferase A [rsmA]. 24 286 48.271 T 09-03-2017 IPR011530 Ribosomal RNA adenine dimethylase GO:0000179|GO:0006364 TK78_RS24380 3002e98eb239be21643e39166e6930d2 388 Pfam PF01757 Acyltransferase family 57 360 4.4E-20 T 09-03-2017 IPR002656 Acyltransferase 3 GO:0016747 TK78_RS19410 33cbb37a587b09e2dbf89c10179f6bca 376 Gene3D G3DSA:2.120.10.30 36 103 1.1E-5 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS19410 33cbb37a587b09e2dbf89c10179f6bca 376 TIGRFAM TIGR02276 beta_rpt_yvtn: 40-residue YVTN family beta-propeller repeat 144 186 3.3E-7 T 09-03-2017 IPR011964 YVTN beta-propeller repeat TK78_RS19410 33cbb37a587b09e2dbf89c10179f6bca 376 SUPERFAMILY SSF51004 44 358 8.63E-28 T 09-03-2017 IPR011048 Cytochrome cd1-nitrite reductase-like, haem d1 domain TK78_RS19410 33cbb37a587b09e2dbf89c10179f6bca 376 Gene3D G3DSA:2.130.10.10 138 375 9.3E-25 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS02120 7314918d9bbbfdeb7a0ab7306f7171d9 340 Pfam PF00356 Bacterial regulatory proteins, lacI family 18 61 1.3E-15 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS02120 7314918d9bbbfdeb7a0ab7306f7171d9 340 Gene3D G3DSA:3.40.50.2300 185 303 2.2E-29 T 09-03-2017 TK78_RS02120 7314918d9bbbfdeb7a0ab7306f7171d9 340 SUPERFAMILY SSF47413 13 73 1.34E-15 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS02120 7314918d9bbbfdeb7a0ab7306f7171d9 340 SUPERFAMILY SSF53822 84 339 3.08E-25 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS02120 7314918d9bbbfdeb7a0ab7306f7171d9 340 Gene3D G3DSA:3.40.50.2300 68 184 3.3E-8 T 09-03-2017 TK78_RS02120 7314918d9bbbfdeb7a0ab7306f7171d9 340 Pfam PF13377 Periplasmic binding protein-like domain 182 340 3.7E-24 T 09-03-2017 TK78_RS02120 7314918d9bbbfdeb7a0ab7306f7171d9 340 Gene3D G3DSA:1.10.260.40 14 67 3.3E-24 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS02120 7314918d9bbbfdeb7a0ab7306f7171d9 340 SMART SM00354 13 85 9.4E-15 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 SUPERFAMILY SSF81653 310 404 3.92E-26 T 09-03-2017 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 TIGRFAM TIGR01511 ATPase-IB1_Cu: copper-translocating P-type ATPase 268 807 6.0E-154 T 09-03-2017 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 Gene3D G3DSA:3.40.50.1000 475 520 8.1E-54 T 09-03-2017 IPR023214 HAD-like domain TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 Gene3D G3DSA:3.40.50.1000 632 772 8.1E-54 T 09-03-2017 IPR023214 HAD-like domain TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 ProSitePatterns PS01229 Hypothetical cof family signature 2. 704 726 - T 09-03-2017 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 Pfam PF00702 haloacid dehalogenase-like hydrolase 501 717 2.7E-46 T 09-03-2017 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 278 783 4.4E-84 T 09-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 704 723 6.9E-24 T 09-03-2017 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 504 518 6.9E-24 T 09-03-2017 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 354 368 6.9E-24 T 09-03-2017 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 629 640 6.9E-24 T 09-03-2017 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 651 661 6.9E-24 T 09-03-2017 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 727 739 6.9E-24 T 09-03-2017 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 Pfam PF00122 E1-E2 ATPase 277 495 5.3E-66 T 09-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 SUPERFAMILY SSF55008 13 83 9.56E-19 T 09-03-2017 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 SUPERFAMILY SSF81665 753 775 1.57E-12 T 09-03-2017 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 SUPERFAMILY SSF81665 274 308 1.57E-12 T 09-03-2017 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 SUPERFAMILY SSF81665 405 498 1.57E-12 T 09-03-2017 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 SUPERFAMILY SSF56784 502 522 1.01E-55 T 09-03-2017 IPR023214 HAD-like domain TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 SUPERFAMILY SSF56784 561 804 1.01E-55 T 09-03-2017 IPR023214 HAD-like domain TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 Gene3D G3DSA:3.30.70.100 16 83 4.1E-21 T 09-03-2017 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 Pfam PF00403 Heavy-metal-associated domain 19 77 2.5E-13 T 09-03-2017 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 Gene3D G3DSA:3.40.1110.10 521 631 2.1E-20 T 09-03-2017 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 Reactome: R-HSA-936837 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 ProSitePatterns PS00154 E1-E2 ATPases phosphorylation site. 506 512 - T 09-03-2017 IPR018303 P-type ATPase, phosphorylation site Reactome: R-HSA-936837 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 TIGRFAM TIGR01525 ATPase-IB_hvy: heavy metal translocating P-type ATPase 223 806 4.1E-182 T 09-03-2017 IPR027256 P-type ATPase, subfamily IB GO:0006812|GO:0016021|GO:0019829 Reactome: R-HSA-936837 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 ProSitePatterns PS01047 Heavy-metal-associated domain. 21 49 - T 09-03-2017 IPR017969 Heavy-metal-associated, conserved site GO:0030001|GO:0046872 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 676 692 1.3E-6 T 09-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 704 720 1.3E-6 T 09-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 735 760 1.3E-6 T 09-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 TK78_RS23890 9e2a56ede016c7ab4406e155089195a6 810 Gene3D G3DSA:2.70.150.10 273 405 7.6E-30 T 09-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 TK78_RS09740 f83214b989ef2c4cc7f14bdfdcb0a0c6 74 ProSitePatterns PS01143 Ribosomal protein L31 signature. 36 57 - T 09-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS09740 f83214b989ef2c4cc7f14bdfdcb0a0c6 74 Hamap MF_00501 50S ribosomal protein L31 [rpmE]. 1 69 28.713 T 09-03-2017 IPR027491 Ribosomal protein L31 type A GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS09740 f83214b989ef2c4cc7f14bdfdcb0a0c6 74 TIGRFAM TIGR00105 L31: ribosomal protein bL31 2 67 2.8E-33 T 09-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS09740 f83214b989ef2c4cc7f14bdfdcb0a0c6 74 PRINTS PR01249 Ribosomal protein L31 signature 47 65 1.2E-20 T 09-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS09740 f83214b989ef2c4cc7f14bdfdcb0a0c6 74 PRINTS PR01249 Ribosomal protein L31 signature 2 19 1.2E-20 T 09-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS09740 f83214b989ef2c4cc7f14bdfdcb0a0c6 74 PRINTS PR01249 Ribosomal protein L31 signature 32 47 1.2E-20 T 09-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS09740 f83214b989ef2c4cc7f14bdfdcb0a0c6 74 SUPERFAMILY SSF143800 1 66 2.04E-24 T 09-03-2017 TK78_RS09740 f83214b989ef2c4cc7f14bdfdcb0a0c6 74 Pfam PF01197 Ribosomal protein L31 2 66 6.4E-30 T 09-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS34630 b7851707274369b84276f692ab677630 501 SUPERFAMILY SSF51206 10 134 1.18E-14 T 09-03-2017 IPR018490 Cyclic nucleotide-binding-like TK78_RS34630 b7851707274369b84276f692ab677630 501 PRINTS PR00344 Bacterial sensor protein C-terminal signature 459 472 7.2E-11 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS34630 b7851707274369b84276f692ab677630 501 PRINTS PR00344 Bacterial sensor protein C-terminal signature 422 432 7.2E-11 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS34630 b7851707274369b84276f692ab677630 501 PRINTS PR00344 Bacterial sensor protein C-terminal signature 404 418 7.2E-11 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS34630 b7851707274369b84276f692ab677630 501 PRINTS PR00344 Bacterial sensor protein C-terminal signature 435 453 7.2E-11 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS34630 b7851707274369b84276f692ab677630 501 SMART SM00100 18 139 0.0037 T 09-03-2017 IPR000595 Cyclic nucleotide-binding domain TK78_RS34630 b7851707274369b84276f692ab677630 501 SMART SM00387 364 475 3.2E-28 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS34630 b7851707274369b84276f692ab677630 501 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 367 474 3.6E-20 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS34630 b7851707274369b84276f692ab677630 501 SUPERFAMILY SSF55874 311 476 7.07E-38 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS34630 b7851707274369b84276f692ab677630 501 Gene3D G3DSA:3.30.565.10 326 473 6.7E-39 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS34630 b7851707274369b84276f692ab677630 501 Pfam PF00027 Cyclic nucleotide-binding domain 44 124 8.3E-7 T 09-03-2017 IPR000595 Cyclic nucleotide-binding domain TK78_RS34630 b7851707274369b84276f692ab677630 501 Gene3D G3DSA:2.60.120.10 15 135 1.5E-12 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS07175 d099bb6c0a44fabb39c6a1847cf62f9b 990 SUPERFAMILY SSF52210 502 659 7.33E-15 T 09-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 TK78_RS07175 d099bb6c0a44fabb39c6a1847cf62f9b 990 Gene3D G3DSA:3.40.630.30 22 186 2.5E-24 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS07175 d099bb6c0a44fabb39c6a1847cf62f9b 990 SUPERFAMILY SSF55729 27 177 3.37E-24 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS07175 d099bb6c0a44fabb39c6a1847cf62f9b 990 Pfam PF13607 Succinyl-CoA ligase like flavodoxin domain 364 497 9.7E-40 T 09-03-2017 IPR032875 Succinyl-CoA synthetase-like, flavodoxin domain TK78_RS07175 d099bb6c0a44fabb39c6a1847cf62f9b 990 Gene3D G3DSA:3.40.50.261 341 496 3.5E-30 T 09-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 TK78_RS07175 d099bb6c0a44fabb39c6a1847cf62f9b 990 SUPERFAMILY SSF52210 342 502 2.75E-31 T 09-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 TK78_RS07175 d099bb6c0a44fabb39c6a1847cf62f9b 990 Pfam PF00583 Acetyltransferase (GNAT) family 88 170 6.4E-11 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS07175 d099bb6c0a44fabb39c6a1847cf62f9b 990 Gene3D G3DSA:3.40.50.720 200 340 1.7E-31 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07175 d099bb6c0a44fabb39c6a1847cf62f9b 990 Pfam PF13380 CoA binding domain 217 345 1.4E-15 T 09-03-2017 IPR003781 CoA-binding GO:0048037 TK78_RS07175 d099bb6c0a44fabb39c6a1847cf62f9b 990 SUPERFAMILY SSF51735 210 340 4.79E-30 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07175 d099bb6c0a44fabb39c6a1847cf62f9b 990 Pfam PF13549 ATP-grasp domain 764 973 8.4E-56 T 09-03-2017 TK78_RS07175 d099bb6c0a44fabb39c6a1847cf62f9b 990 SUPERFAMILY SSF56059 769 967 1.84E-22 T 09-03-2017 TK78_RS07175 d099bb6c0a44fabb39c6a1847cf62f9b 990 SMART SM00881 212 311 5.4E-28 T 09-03-2017 IPR003781 CoA-binding GO:0048037 TK78_RS07175 d099bb6c0a44fabb39c6a1847cf62f9b 990 Gene3D G3DSA:3.40.50.261 503 613 1.5E-8 T 09-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 TK78_RS21470 21bd6172a295e6f14c80657033c6595d 861 Pfam PF02687 FtsX-like permease family 275 395 6.8E-24 T 09-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 TK78_RS21470 21bd6172a295e6f14c80657033c6595d 861 Pfam PF02687 FtsX-like permease family 737 852 4.0E-20 T 09-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 TK78_RS21470 21bd6172a295e6f14c80657033c6595d 861 Pfam PF12704 MacB-like periplasmic core domain 19 237 1.2E-13 T 09-03-2017 IPR025857 MacB-like periplasmic core domain TK78_RS21470 21bd6172a295e6f14c80657033c6595d 861 Pfam PF12704 MacB-like periplasmic core domain 500 700 2.1E-11 T 09-03-2017 IPR025857 MacB-like periplasmic core domain TK78_RS13155 c1eb54d269eda8496a0fcd5e1ae4449d 107 ProSitePatterns PS00050 Ribosomal protein L23 signature. 87 102 - T 09-03-2017 IPR001014 Ribosomal protein L23/L25, conserved site Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13155 c1eb54d269eda8496a0fcd5e1ae4449d 107 SUPERFAMILY SSF54189 13 104 6.83E-33 T 09-03-2017 IPR012678 Ribosomal protein L23/L15e core domain GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13155 c1eb54d269eda8496a0fcd5e1ae4449d 107 Gene3D G3DSA:3.30.70.330 13 103 8.6E-37 T 09-03-2017 IPR012677 Nucleotide-binding alpha-beta plait domain GO:0000166 TK78_RS13155 c1eb54d269eda8496a0fcd5e1ae4449d 107 Hamap MF_01369_B 50S ribosomal protein L23 [rplW]. 15 104 22.288 T 09-03-2017 IPR013025 Ribosomal protein L25/L23 GO:0003735|GO:0005840|GO:0006412 TK78_RS13155 c1eb54d269eda8496a0fcd5e1ae4449d 107 Pfam PF00276 Ribosomal protein L23 16 101 1.4E-32 T 09-03-2017 IPR013025 Ribosomal protein L25/L23 GO:0003735|GO:0005840|GO:0006412 TK78_RS09435 8e060363c21a6bc2702085381c7b9158 208 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 44 67 8.8E-6 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS09435 8e060363c21a6bc2702085381c7b9158 208 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 23 36 8.8E-6 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS09435 8e060363c21a6bc2702085381c7b9158 208 Pfam PF16859 Bacterial transcriptional repressor C-terminal 79 192 8.7E-18 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS09435 8e060363c21a6bc2702085381c7b9158 208 SUPERFAMILY SSF48498 83 202 6.47E-16 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS09435 8e060363c21a6bc2702085381c7b9158 208 Gene3D G3DSA:1.10.10.60 13 59 3.4E-20 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS09435 8e060363c21a6bc2702085381c7b9158 208 Gene3D G3DSA:1.10.357.10 62 202 2.6E-36 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS09435 8e060363c21a6bc2702085381c7b9158 208 SUPERFAMILY SSF46689 14 77 1.03E-13 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS09435 8e060363c21a6bc2702085381c7b9158 208 Pfam PF00440 Bacterial regulatory proteins, tetR family 23 67 1.9E-12 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS23865 30f6fff9e3ce1bf40ef745de8051bca6 227 SMART SM00448 9 124 7.3E-26 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS23865 30f6fff9e3ce1bf40ef745de8051bca6 227 Gene3D G3DSA:3.40.50.2300 9 160 2.7E-32 T 09-03-2017 TK78_RS23865 30f6fff9e3ce1bf40ef745de8051bca6 227 SMART SM00421 158 215 2.0E-22 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS23865 30f6fff9e3ce1bf40ef745de8051bca6 227 SUPERFAMILY SSF46894 150 221 5.44E-19 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS23865 30f6fff9e3ce1bf40ef745de8051bca6 227 Pfam PF00196 Bacterial regulatory proteins, luxR family 160 213 3.7E-16 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS23865 30f6fff9e3ce1bf40ef745de8051bca6 227 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 191 203 9.2E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS23865 30f6fff9e3ce1bf40ef745de8051bca6 227 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 161 175 9.2E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS23865 30f6fff9e3ce1bf40ef745de8051bca6 227 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 175 191 9.2E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS23865 30f6fff9e3ce1bf40ef745de8051bca6 227 Pfam PF00072 Response regulator receiver domain 11 123 1.1E-22 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS23865 30f6fff9e3ce1bf40ef745de8051bca6 227 SUPERFAMILY SSF52172 8 139 1.42E-29 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS23865 30f6fff9e3ce1bf40ef745de8051bca6 227 Gene3D G3DSA:1.10.10.10 161 220 5.6E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS01020 875f3c180b08f07fc583cb0ce3635866 993 SUPERFAMILY SSF52540 518 736 1.06E-51 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01020 875f3c180b08f07fc583cb0ce3635866 993 SMART SM00490 850 932 2.0E-23 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS01020 875f3c180b08f07fc583cb0ce3635866 993 Pfam PF00271 Helicase conserved C-terminal domain 822 932 1.1E-17 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS01020 875f3c180b08f07fc583cb0ce3635866 993 Gene3D G3DSA:3.40.50.300 816 965 2.0E-22 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01020 875f3c180b08f07fc583cb0ce3635866 993 SUPERFAMILY SSF52540 743 988 1.1E-67 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01020 875f3c180b08f07fc583cb0ce3635866 993 Gene3D G3DSA:3.40.50.300 523 690 2.8E-23 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01020 875f3c180b08f07fc583cb0ce3635866 993 SMART SM00487 523 708 1.5E-29 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS01020 875f3c180b08f07fc583cb0ce3635866 993 Pfam PF12419 SNF2 Helicase protein 328 480 5.0E-43 T 09-03-2017 IPR022138 Helicase SWF/SNF-related TK78_RS01020 875f3c180b08f07fc583cb0ce3635866 993 Pfam PF00176 SNF2 family N-terminal domain 545 805 1.7E-51 T 09-03-2017 IPR000330 SNF2-related, N-terminal domain GO:0005524 TK78_RS24650 7bebe295cd5e3301a44ee7179d877157 281 Gene3D G3DSA:3.40.50.10170 5 150 1.9E-44 T 09-03-2017 TK78_RS24650 7bebe295cd5e3301a44ee7179d877157 281 TIGRFAM TIGR00762 DegV: EDD domain protein, DegV family 5 278 7.7E-88 T 09-03-2017 IPR003797 DegV TK78_RS24650 7bebe295cd5e3301a44ee7179d877157 281 Gene3D G3DSA:3.30.1180.10 155 278 5.0E-43 T 09-03-2017 TK78_RS24650 7bebe295cd5e3301a44ee7179d877157 281 SUPERFAMILY SSF82549 5 278 2.49E-77 T 09-03-2017 TK78_RS24650 7bebe295cd5e3301a44ee7179d877157 281 Pfam PF02645 Uncharacterised protein, DegV family COG1307 5 279 8.3E-88 T 09-03-2017 IPR003797 DegV TK78_RS24160 c4282bf9031f7faf0ac304e60db41ac1 401 Gene3D G3DSA:1.10.10.10 12 80 7.1E-15 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS24160 c4282bf9031f7faf0ac304e60db41ac1 401 Gene3D G3DSA:3.30.420.40 222 369 2.2E-35 T 09-03-2017 TK78_RS24160 c4282bf9031f7faf0ac304e60db41ac1 401 Pfam PF00480 ROK family 86 367 3.0E-29 T 09-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 TK78_RS24160 c4282bf9031f7faf0ac304e60db41ac1 401 SUPERFAMILY SSF53067 85 390 3.48E-45 T 09-03-2017 TK78_RS24160 c4282bf9031f7faf0ac304e60db41ac1 401 SMART SM00418 10 91 0.0059 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS24160 c4282bf9031f7faf0ac304e60db41ac1 401 Gene3D G3DSA:3.30.420.40 81 221 9.5E-37 T 09-03-2017 TK78_RS24160 c4282bf9031f7faf0ac304e60db41ac1 401 Pfam PF12802 MarR family 18 62 2.3E-7 T 09-03-2017 TK78_RS24160 c4282bf9031f7faf0ac304e60db41ac1 401 SUPERFAMILY SSF46785 13 79 1.44E-12 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05405 d2783df5565807d4ada0e08015a402ee 301 SUPERFAMILY SSF53850 91 295 2.53E-40 T 09-03-2017 TK78_RS05405 d2783df5565807d4ada0e08015a402ee 301 Pfam PF03466 LysR substrate binding domain 91 293 5.9E-45 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS05405 d2783df5565807d4ada0e08015a402ee 301 SUPERFAMILY SSF46785 1 84 5.59E-25 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05405 d2783df5565807d4ada0e08015a402ee 301 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 3 62 2.3E-22 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS05405 d2783df5565807d4ada0e08015a402ee 301 Gene3D G3DSA:3.40.190.10 176 266 1.6E-32 T 09-03-2017 TK78_RS05405 d2783df5565807d4ada0e08015a402ee 301 Gene3D G3DSA:1.10.10.10 1 84 7.5E-31 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05405 d2783df5565807d4ada0e08015a402ee 301 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 3.4E-10 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS05405 d2783df5565807d4ada0e08015a402ee 301 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 3.4E-10 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS05405 d2783df5565807d4ada0e08015a402ee 301 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 3.4E-10 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS05405 d2783df5565807d4ada0e08015a402ee 301 Gene3D G3DSA:3.40.190.10 88 175 5.2E-23 T 09-03-2017 TK78_RS29800 cc3f527e0d57d7d663ff89b3ceee8508 342 ProSitePatterns PS01224 N-acetyl-gamma-glutamyl-phosphate reductase active site. 141 157 - T 09-03-2017 IPR023013 N-acetyl-gamma-glutamyl-phosphate reductase, active site GO:0003942|GO:0055114 KEGG: 00220+1.2.1.38|MetaCyc: PWY-5154|MetaCyc: PWY-7400 TK78_RS29800 cc3f527e0d57d7d663ff89b3ceee8508 342 Pfam PF02774 Semialdehyde dehydrogenase, dimerisation domain 155 313 1.9E-22 T 09-03-2017 IPR012280 Semialdehyde dehydrogenase, dimerisation domain GO:0003942|GO:0005737|GO:0008652|GO:0016620|GO:0046983|GO:0055114 KEGG: 00220+1.2.1.38|MetaCyc: PWY-5154|MetaCyc: PWY-7400 TK78_RS29800 cc3f527e0d57d7d663ff89b3ceee8508 342 SUPERFAMILY SSF55347 146 310 4.03E-49 T 09-03-2017 TK78_RS29800 cc3f527e0d57d7d663ff89b3ceee8508 342 TIGRFAM TIGR01850 argC: N-acetyl-gamma-glutamyl-phosphate reductase 4 342 1.8E-118 T 09-03-2017 IPR000706 N-acetyl-gamma-glutamyl-phosphate reductase, type 1 GO:0003942|GO:0006526|GO:0055114 KEGG: 00220+1.2.1.38|MetaCyc: PWY-5154|MetaCyc: PWY-7400 TK78_RS29800 cc3f527e0d57d7d663ff89b3ceee8508 342 Pfam PF01118 Semialdehyde dehydrogenase, NAD binding domain 4 128 3.5E-27 T 09-03-2017 IPR000534 Semialdehyde dehydrogenase, NAD-binding GO:0016620|GO:0051287|GO:0055114 TK78_RS29800 cc3f527e0d57d7d663ff89b3ceee8508 342 Gene3D G3DSA:3.30.360.10 155 310 3.1E-58 T 09-03-2017 TK78_RS29800 cc3f527e0d57d7d663ff89b3ceee8508 342 SUPERFAMILY SSF51735 4 170 1.3E-45 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS29800 cc3f527e0d57d7d663ff89b3ceee8508 342 Hamap MF_00150 N-acetyl-gamma-glutamyl-phosphate reductase [argC]. 3 336 38.159 T 09-03-2017 IPR000706 N-acetyl-gamma-glutamyl-phosphate reductase, type 1 GO:0003942|GO:0006526|GO:0055114 KEGG: 00220+1.2.1.38|MetaCyc: PWY-5154|MetaCyc: PWY-7400 TK78_RS29800 cc3f527e0d57d7d663ff89b3ceee8508 342 SMART SM00859 4 136 1.6E-45 T 09-03-2017 IPR000534 Semialdehyde dehydrogenase, NAD-binding GO:0016620|GO:0051287|GO:0055114 TK78_RS29800 cc3f527e0d57d7d663ff89b3ceee8508 342 Gene3D G3DSA:3.40.50.720 3 154 4.2E-53 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS05545 1cfb3dda6ffe9503f01f697334b38085 341 Pfam PF01032 FecCD transport family 19 335 1.9E-87 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS05545 1cfb3dda6ffe9503f01f697334b38085 341 SUPERFAMILY SSF81345 4 336 8.5E-78 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS05545 1cfb3dda6ffe9503f01f697334b38085 341 Gene3D G3DSA:1.10.3470.10 6 337 7.0E-100 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS06005 dcd3ec1060738973cc57e838dd50270d 370 Gene3D G3DSA:3.40.50.2300 166 342 5.9E-39 T 09-03-2017 TK78_RS06005 dcd3ec1060738973cc57e838dd50270d 370 SUPERFAMILY SSF53822 44 343 6.23E-66 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS06005 dcd3ec1060738973cc57e838dd50270d 370 Pfam PF13407 Periplasmic binding protein domain 50 308 6.3E-66 T 09-03-2017 IPR025997 Periplasmic binding protein TK78_RS06005 dcd3ec1060738973cc57e838dd50270d 370 Gene3D G3DSA:3.40.50.2300 40 165 1.7E-30 T 09-03-2017 TK78_RS00550 3d4e1d0487bc488c4636b56a733aba50 416 SUPERFAMILY SSF48264 28 416 6.68E-94 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS00550 3d4e1d0487bc488c4636b56a733aba50 416 Gene3D G3DSA:1.10.630.10 11 416 2.7E-119 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS00550 3d4e1d0487bc488c4636b56a733aba50 416 Pfam PF00067 Cytochrome P450 288 385 1.6E-20 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS00550 3d4e1d0487bc488c4636b56a733aba50 416 PRINTS PR00385 P450 superfamily signature 255 272 1.1E-9 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS00550 3d4e1d0487bc488c4636b56a733aba50 416 PRINTS PR00385 P450 superfamily signature 290 301 1.1E-9 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS00550 3d4e1d0487bc488c4636b56a733aba50 416 PRINTS PR00385 P450 superfamily signature 356 365 1.1E-9 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS00550 3d4e1d0487bc488c4636b56a733aba50 416 PRINTS PR00385 P450 superfamily signature 365 376 1.1E-9 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS00550 3d4e1d0487bc488c4636b56a733aba50 416 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 358 367 - T 09-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 TK78_RS00550 3d4e1d0487bc488c4636b56a733aba50 416 PRINTS PR00359 B-class P450 signature 109 120 4.6E-52 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS00550 3d4e1d0487bc488c4636b56a733aba50 416 PRINTS PR00359 B-class P450 signature 307 334 4.6E-52 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS00550 3d4e1d0487bc488c4636b56a733aba50 416 PRINTS PR00359 B-class P450 signature 335 350 4.6E-52 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS00550 3d4e1d0487bc488c4636b56a733aba50 416 PRINTS PR00359 B-class P450 signature 290 301 4.6E-52 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS00550 3d4e1d0487bc488c4636b56a733aba50 416 PRINTS PR00359 B-class P450 signature 365 376 4.6E-52 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS00550 3d4e1d0487bc488c4636b56a733aba50 416 PRINTS PR00359 B-class P450 signature 356 365 4.6E-52 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS00550 3d4e1d0487bc488c4636b56a733aba50 416 PRINTS PR00359 B-class P450 signature 156 172 4.6E-52 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS00550 3d4e1d0487bc488c4636b56a733aba50 416 PRINTS PR00359 B-class P450 signature 173 188 4.6E-52 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS00550 3d4e1d0487bc488c4636b56a733aba50 416 PRINTS PR00359 B-class P450 signature 209 231 4.6E-52 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS20725 8115959a43fd5bde529ecef150517d93 1176 SMART SM00490 530 615 3.3E-22 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS20725 8115959a43fd5bde529ecef150517d93 1176 SUPERFAMILY SSF52540 109 295 2.74E-31 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS20725 8115959a43fd5bde529ecef150517d93 1176 Gene3D G3DSA:3.40.50.300 110 287 1.9E-18 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS20725 8115959a43fd5bde529ecef150517d93 1176 Pfam PF00271 Helicase conserved C-terminal domain 511 615 1.1E-20 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS20725 8115959a43fd5bde529ecef150517d93 1176 Pfam PF00176 SNF2 family N-terminal domain 131 360 9.0E-11 T 09-03-2017 IPR000330 SNF2-related, N-terminal domain GO:0005524 TK78_RS20725 8115959a43fd5bde529ecef150517d93 1176 Pfam PF13020 Domain of unknown function (DUF3883) 1056 1136 3.4E-15 T 09-03-2017 IPR024975 Domain of unknown function DUF3883 TK78_RS20725 8115959a43fd5bde529ecef150517d93 1176 Gene3D G3DSA:3.40.50.300 482 646 6.0E-30 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS20725 8115959a43fd5bde529ecef150517d93 1176 SUPERFAMILY SSF52540 485 655 1.83E-48 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS20725 8115959a43fd5bde529ecef150517d93 1176 SUPERFAMILY SSF52540 228 296 1.83E-48 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS20725 8115959a43fd5bde529ecef150517d93 1176 SMART SM00487 106 306 3.8E-19 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS16755 fc53452640a7728c826faf1b0d64d1bc 1382 SMART SM00091 10 76 3.3E-8 T 09-03-2017 IPR000014 PAS domain TK78_RS16755 fc53452640a7728c826faf1b0d64d1bc 1382 SMART SM00091 149 217 2.6E-5 T 09-03-2017 IPR000014 PAS domain TK78_RS16755 fc53452640a7728c826faf1b0d64d1bc 1382 SUPERFAMILY SSF55785 140 264 2.27E-18 T 09-03-2017 IPR000014 PAS domain TK78_RS16755 fc53452640a7728c826faf1b0d64d1bc 1382 Pfam PF00989 PAS fold 11 107 8.9E-7 T 09-03-2017 IPR013767 PAS fold GO:0006355 TK78_RS16755 fc53452640a7728c826faf1b0d64d1bc 1382 Pfam PF00989 PAS fold 153 264 4.0E-12 T 09-03-2017 IPR013767 PAS fold GO:0006355 TK78_RS16755 fc53452640a7728c826faf1b0d64d1bc 1382 Gene3D G3DSA:3.40.50.2300 1256 1376 6.0E-12 T 09-03-2017 TK78_RS16755 fc53452640a7728c826faf1b0d64d1bc 1382 SUPERFAMILY SSF52172 1255 1345 1.57E-12 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS16755 fc53452640a7728c826faf1b0d64d1bc 1382 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 152 264 2.5E-8 T 09-03-2017 IPR000014 PAS domain TK78_RS16755 fc53452640a7728c826faf1b0d64d1bc 1382 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 10 111 6.0E-7 T 09-03-2017 IPR000014 PAS domain TK78_RS16755 fc53452640a7728c826faf1b0d64d1bc 1382 Gene3D G3DSA:3.30.450.20 144 264 1.5E-21 T 09-03-2017 TK78_RS16755 fc53452640a7728c826faf1b0d64d1bc 1382 Pfam PF00072 Response regulator receiver domain 1260 1342 9.5E-6 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS16755 fc53452640a7728c826faf1b0d64d1bc 1382 Gene3D G3DSA:3.30.450.20 14 112 9.0E-14 T 09-03-2017 TK78_RS16755 fc53452640a7728c826faf1b0d64d1bc 1382 SUPERFAMILY SSF55785 10 106 2.79E-12 T 09-03-2017 IPR000014 PAS domain TK78_RS06595 b82bc5f1982a494fc4b09cd3ed48195c 236 SMART SM00345 20 78 9.4E-14 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS06595 b82bc5f1982a494fc4b09cd3ed48195c 236 SUPERFAMILY SSF46785 15 82 3.52E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS06595 b82bc5f1982a494fc4b09cd3ed48195c 236 Pfam PF00392 Bacterial regulatory proteins, gntR family 17 78 1.2E-15 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS06595 b82bc5f1982a494fc4b09cd3ed48195c 236 Gene3D G3DSA:1.10.10.10 13 79 8.6E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS06595 b82bc5f1982a494fc4b09cd3ed48195c 236 Pfam PF07729 FCD domain 90 211 1.2E-22 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS06595 b82bc5f1982a494fc4b09cd3ed48195c 236 SMART SM00895 88 212 2.5E-13 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS06595 b82bc5f1982a494fc4b09cd3ed48195c 236 Gene3D G3DSA:1.20.120.530 81 221 2.4E-27 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS06595 b82bc5f1982a494fc4b09cd3ed48195c 236 SUPERFAMILY SSF48008 85 217 4.71E-26 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS28705 780a757016a782c3d8227acb56b77c0b 141 SUPERFAMILY SSF50022 49 140 6.81E-25 T 09-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 TK78_RS28705 780a757016a782c3d8227acb56b77c0b 141 PRINTS PR00162 Rieske 2Fe-2S subunit signature 114 126 5.0E-6 T 09-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 TK78_RS28705 780a757016a782c3d8227acb56b77c0b 141 PRINTS PR00162 Rieske 2Fe-2S subunit signature 101 113 5.0E-6 T 09-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 TK78_RS28705 780a757016a782c3d8227acb56b77c0b 141 PRINTS PR00162 Rieske 2Fe-2S subunit signature 81 92 5.0E-6 T 09-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 TK78_RS28705 780a757016a782c3d8227acb56b77c0b 141 Pfam PF00355 Rieske [2Fe-2S] domain 51 127 4.2E-15 T 09-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 TK78_RS28705 780a757016a782c3d8227acb56b77c0b 141 Gene3D G3DSA:2.102.10.10 3 138 1.2E-27 T 09-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 TK78_RS13780 7834f4b34cf23de61ccb98ce2c668fbf 986 Pfam PF03704 Bacterial transcriptional activator domain 119 263 3.4E-41 T 09-03-2017 IPR005158 Bacterial transcriptional activator domain TK78_RS13780 7834f4b34cf23de61ccb98ce2c668fbf 986 Gene3D G3DSA:1.10.10.10 47 104 4.7E-7 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS13780 7834f4b34cf23de61ccb98ce2c668fbf 986 Gene3D G3DSA:3.40.50.300 321 415 6.1E-5 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13780 7834f4b34cf23de61ccb98ce2c668fbf 986 PRINTS PR00364 Disease resistance protein signature 481 495 1.7E-9 T 09-03-2017 TK78_RS13780 7834f4b34cf23de61ccb98ce2c668fbf 986 PRINTS PR00364 Disease resistance protein signature 319 334 1.7E-9 T 09-03-2017 TK78_RS13780 7834f4b34cf23de61ccb98ce2c668fbf 986 PRINTS PR00364 Disease resistance protein signature 396 410 1.7E-9 T 09-03-2017 TK78_RS13780 7834f4b34cf23de61ccb98ce2c668fbf 986 SMART SM01043 119 263 3.9E-48 T 09-03-2017 IPR005158 Bacterial transcriptional activator domain TK78_RS13780 7834f4b34cf23de61ccb98ce2c668fbf 986 Pfam PF13424 Tetratricopeptide repeat 776 844 1.1E-10 T 09-03-2017 TK78_RS13780 7834f4b34cf23de61ccb98ce2c668fbf 986 SUPERFAMILY SSF48452 855 970 1.55E-10 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS13780 7834f4b34cf23de61ccb98ce2c668fbf 986 SUPERFAMILY SSF48452 117 287 1.39E-31 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS13780 7834f4b34cf23de61ccb98ce2c668fbf 986 Gene3D G3DSA:1.25.40.10 730 873 8.6E-16 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS13780 7834f4b34cf23de61ccb98ce2c668fbf 986 Gene3D G3DSA:1.25.40.10 874 980 3.2E-9 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS13780 7834f4b34cf23de61ccb98ce2c668fbf 986 SMART SM00862 40 112 5.5E-7 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS13780 7834f4b34cf23de61ccb98ce2c668fbf 986 SUPERFAMILY SSF52540 284 548 1.24E-28 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13780 7834f4b34cf23de61ccb98ce2c668fbf 986 SMART SM00028 773 806 82.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS13780 7834f4b34cf23de61ccb98ce2c668fbf 986 SMART SM00028 935 968 27.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS13780 7834f4b34cf23de61ccb98ce2c668fbf 986 SMART SM00028 855 888 31.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS13780 7834f4b34cf23de61ccb98ce2c668fbf 986 SMART SM00028 813 846 40.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS13780 7834f4b34cf23de61ccb98ce2c668fbf 986 SUPERFAMILY SSF46894 27 102 3.4E-12 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS13780 7834f4b34cf23de61ccb98ce2c668fbf 986 Pfam PF00486 Transcriptional regulatory protein, C terminal 47 106 1.5E-8 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS13780 7834f4b34cf23de61ccb98ce2c668fbf 986 SUPERFAMILY SSF48452 730 875 1.73E-12 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS13780 7834f4b34cf23de61ccb98ce2c668fbf 986 Pfam PF00931 NB-ARC domain 304 500 9.4E-14 T 09-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 TK78_RS01220 071316b1ce78cc148d8a2f04649d6102 128 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 13 114 1.5E-12 T 09-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain TK78_RS01220 071316b1ce78cc148d8a2f04649d6102 128 Gene3D G3DSA:3.10.180.10 9 123 1.5E-26 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS01220 071316b1ce78cc148d8a2f04649d6102 128 SUPERFAMILY SSF54593 10 122 5.77E-25 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS19825 595217ad11778ceb1cf3e82d9b765fd8 445 Gene3D G3DSA:1.10.287.130 210 262 5.1E-12 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS19825 595217ad11778ceb1cf3e82d9b765fd8 445 SMART SM00388 218 276 1.1E-12 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS19825 595217ad11778ceb1cf3e82d9b765fd8 445 Pfam PF00672 HAMP domain 142 213 2.6E-9 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS19825 595217ad11778ceb1cf3e82d9b765fd8 445 SMART SM00387 314 425 3.0E-22 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS19825 595217ad11778ceb1cf3e82d9b765fd8 445 SUPERFAMILY SSF55874 265 423 1.11E-20 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS19825 595217ad11778ceb1cf3e82d9b765fd8 445 SMART SM00304 161 217 7.9E-7 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS19825 595217ad11778ceb1cf3e82d9b765fd8 445 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 314 423 6.3E-13 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS19825 595217ad11778ceb1cf3e82d9b765fd8 445 SUPERFAMILY SSF47384 201 275 5.3E-12 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS19825 595217ad11778ceb1cf3e82d9b765fd8 445 Gene3D G3DSA:3.30.565.10 263 407 1.9E-20 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS19825 595217ad11778ceb1cf3e82d9b765fd8 445 Pfam PF00512 His Kinase A (phospho-acceptor) domain 219 275 1.1E-10 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS18800 8e590665a3b6a689b86bbddb5eebdf43 488 SMART SM00304 208 261 1.4E-13 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS18800 8e590665a3b6a689b86bbddb5eebdf43 488 PRINTS PR00344 Bacterial sensor protein C-terminal signature 407 421 2.0E-11 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS18800 8e590665a3b6a689b86bbddb5eebdf43 488 PRINTS PR00344 Bacterial sensor protein C-terminal signature 425 435 2.0E-11 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS18800 8e590665a3b6a689b86bbddb5eebdf43 488 PRINTS PR00344 Bacterial sensor protein C-terminal signature 440 458 2.0E-11 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS18800 8e590665a3b6a689b86bbddb5eebdf43 488 PRINTS PR00344 Bacterial sensor protein C-terminal signature 466 479 2.0E-11 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS18800 8e590665a3b6a689b86bbddb5eebdf43 488 SUPERFAMILY SSF158472 211 258 6.15E-8 T 09-03-2017 TK78_RS18800 8e590665a3b6a689b86bbddb5eebdf43 488 SUPERFAMILY SSF47384 245 332 2.55E-13 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS18800 8e590665a3b6a689b86bbddb5eebdf43 488 Gene3D G3DSA:3.30.565.10 340 486 5.0E-33 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS18800 8e590665a3b6a689b86bbddb5eebdf43 488 Pfam PF00512 His Kinase A (phospho-acceptor) domain 263 332 3.0E-12 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS18800 8e590665a3b6a689b86bbddb5eebdf43 488 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 377 479 6.9E-21 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS18800 8e590665a3b6a689b86bbddb5eebdf43 488 SMART SM00388 262 333 4.9E-11 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS18800 8e590665a3b6a689b86bbddb5eebdf43 488 Pfam PF00672 HAMP domain 189 256 9.4E-16 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS18800 8e590665a3b6a689b86bbddb5eebdf43 488 SMART SM00387 374 482 9.9E-33 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS18800 8e590665a3b6a689b86bbddb5eebdf43 488 SUPERFAMILY SSF55874 338 482 8.51E-32 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS18800 8e590665a3b6a689b86bbddb5eebdf43 488 Gene3D G3DSA:1.10.287.130 252 329 1.0E-13 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS00230 74e9ea4d9a217d90b51248461410abb5 154 SUPERFAMILY SSF46785 7 150 1.37E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS00230 74e9ea4d9a217d90b51248461410abb5 154 Pfam PF12802 MarR family 38 98 9.5E-10 T 09-03-2017 TK78_RS00230 74e9ea4d9a217d90b51248461410abb5 154 SMART SM00347 33 135 7.4E-8 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS00230 74e9ea4d9a217d90b51248461410abb5 154 Gene3D G3DSA:1.10.10.10 2 151 2.0E-29 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS33900 831bf92554c6e8f5ef6d677a3e8cab69 620 ProSitePatterns PS00544 Methylmalonyl-CoA mutase signature. 361 386 - T 09-03-2017 IPR006099 Methylmalonyl-CoA mutase, alpha/beta chain, catalytic GO:0008152|GO:0016866|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 TK78_RS33900 831bf92554c6e8f5ef6d677a3e8cab69 620 Gene3D G3DSA:3.40.50.280 490 619 9.4E-47 T 09-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 TK78_RS33900 831bf92554c6e8f5ef6d677a3e8cab69 620 Pfam PF01642 Methylmalonyl-CoA mutase 52 532 3.6E-135 T 09-03-2017 IPR006099 Methylmalonyl-CoA mutase, alpha/beta chain, catalytic GO:0008152|GO:0016866|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 TK78_RS33900 831bf92554c6e8f5ef6d677a3e8cab69 620 Gene3D G3DSA:1.10.196.20 8 41 1.7E-8 T 09-03-2017 IPR024067 Methylmalonyl-CoA mutase small subunit, N-terminal KEGG: 00280+5.4.99.2|KEGG: 00630+5.4.99.2|KEGG: 00640+5.4.99.2|KEGG: 00720+5.4.99.2|MetaCyc: PWY-5743|MetaCyc: PWY-5789|MetaCyc: PWY-6728|MetaCyc: PWY-7384 TK78_RS33900 831bf92554c6e8f5ef6d677a3e8cab69 620 Gene3D G3DSA:3.20.20.240 51 485 1.8E-138 T 09-03-2017 IPR014348 Cobalamin (vitamin B12)-dependent enzyme, catalytic subdomain GO:0008152|GO:0016866|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 TK78_RS33900 831bf92554c6e8f5ef6d677a3e8cab69 620 SUPERFAMILY SSF51703 12 539 1.61E-153 T 09-03-2017 IPR016176 Cobalamin (vitamin B12)-dependent enzyme, catalytic GO:0003824|GO:0008152|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 TK78_RS06000 fa7ab0e4ed18b559b21866c3d4f63d64 262 Gene3D G3DSA:3.40.50.300 7 223 1.0E-61 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06000 fa7ab0e4ed18b559b21866c3d4f63d64 262 SUPERFAMILY SSF52540 8 225 6.88E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06000 fa7ab0e4ed18b559b21866c3d4f63d64 262 SMART SM00382 34 223 1.1E-12 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS06000 fa7ab0e4ed18b559b21866c3d4f63d64 262 Pfam PF00005 ABC transporter 25 175 2.2E-30 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS28225 c2f4aa0803d8240f5345c599ca3ec077 199 Pfam PF02572 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP 22 199 7.6E-59 T 09-03-2017 IPR003724 ATP:cob(I)alamin adenosyltransferase CobA/CobO/ButR GO:0005524|GO:0008817|GO:0009236 KEGG: 00860+2.5.1.17|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6268|MetaCyc: PWY-6269 TK78_RS28225 c2f4aa0803d8240f5345c599ca3ec077 199 SUPERFAMILY SSF52540 12 199 1.38E-60 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28225 c2f4aa0803d8240f5345c599ca3ec077 199 PIRSF PIRSF015617 1 199 2.5E-64 T 09-03-2017 IPR003724 ATP:cob(I)alamin adenosyltransferase CobA/CobO/ButR GO:0005524|GO:0008817|GO:0009236 KEGG: 00860+2.5.1.17|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6268|MetaCyc: PWY-6269 TK78_RS28225 c2f4aa0803d8240f5345c599ca3ec077 199 Gene3D G3DSA:3.40.50.300 7 199 5.5E-67 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28225 c2f4aa0803d8240f5345c599ca3ec077 199 TIGRFAM TIGR00708 cobA: cob(I)yrinic acid a,c-diamide adenosyltransferase 19 199 6.6E-70 T 09-03-2017 IPR003724 ATP:cob(I)alamin adenosyltransferase CobA/CobO/ButR GO:0005524|GO:0008817|GO:0009236 KEGG: 00860+2.5.1.17|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6268|MetaCyc: PWY-6269 TK78_RS32270 8b7563cec389542323b247c7a967de62 75 Pfam PF09360 Iron-binding zinc finger CDGSH type 4 49 1.6E-15 T 09-03-2017 IPR018967 Iron sulphur-containing domain, CDGSH-type GO:0043231|GO:0051537 TK78_RS32270 8b7563cec389542323b247c7a967de62 75 SMART SM00704 10 54 7.3E-9 T 09-03-2017 IPR018967 Iron sulphur-containing domain, CDGSH-type GO:0043231|GO:0051537 TK78_RS02445 27c7a522f17ac961f82263c3ab3a015c 337 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 126 330 2.8E-20 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS02445 27c7a522f17ac961f82263c3ab3a015c 337 Gene3D G3DSA:1.10.3720.10 106 331 4.2E-61 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS02445 27c7a522f17ac961f82263c3ab3a015c 337 SUPERFAMILY SSF161098 89 322 1.57E-56 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS08690 7e831eccb38691968fec85cad90ac8ec 367 Gene3D G3DSA:3.30.470.10 20 179 1.7E-72 T 09-03-2017 TK78_RS08690 7e831eccb38691968fec85cad90ac8ec 367 PIRSF PIRSF006468 5 367 2.0E-129 T 09-03-2017 IPR005786 Branched-chain amino acid aminotransferase II GO:0004084|GO:0009081 KEGG: 00270+2.6.1.42|KEGG: 00280+2.6.1.42|KEGG: 00290+2.6.1.42|KEGG: 00770+2.6.1.42|KEGG: 00966+2.6.1.42|MetaCyc: PWY-5057|MetaCyc: PWY-5076|MetaCyc: PWY-5078|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-5108|Reactome: R-HSA-70895 TK78_RS08690 7e831eccb38691968fec85cad90ac8ec 367 TIGRFAM TIGR01123 ilvE_II: branched-chain amino acid aminotransferase 48 364 8.7E-129 T 09-03-2017 IPR005786 Branched-chain amino acid aminotransferase II GO:0004084|GO:0009081 KEGG: 00270+2.6.1.42|KEGG: 00280+2.6.1.42|KEGG: 00290+2.6.1.42|KEGG: 00770+2.6.1.42|KEGG: 00966+2.6.1.42|MetaCyc: PWY-5057|MetaCyc: PWY-5076|MetaCyc: PWY-5078|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-5108|Reactome: R-HSA-70895 TK78_RS08690 7e831eccb38691968fec85cad90ac8ec 367 ProSitePatterns PS00770 Aminotransferases class-IV signature. 238 272 - T 09-03-2017 IPR018300 Aminotransferase, class IV, conserved site GO:0003824|GO:0008152 Reactome: R-HSA-70895 TK78_RS08690 7e831eccb38691968fec85cad90ac8ec 367 Pfam PF01063 Amino-transferase class IV 74 321 2.6E-26 T 09-03-2017 IPR001544 Aminotransferase class IV GO:0003824|GO:0008152 Reactome: R-HSA-70895 TK78_RS08690 7e831eccb38691968fec85cad90ac8ec 367 Gene3D G3DSA:3.20.10.10 180 353 6.0E-63 T 09-03-2017 TK78_RS08690 7e831eccb38691968fec85cad90ac8ec 367 SUPERFAMILY SSF56752 12 364 1.7E-113 T 09-03-2017 IPR001544 Aminotransferase class IV GO:0003824|GO:0008152 Reactome: R-HSA-70895 TK78_RS32570 6a64687329803f608f691f5532492590 429 SMART SM00220 7 263 4.5E-65 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS32570 6a64687329803f608f691f5532492590 429 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 125 137 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS32570 6a64687329803f608f691f5532492590 429 Gene3D G3DSA:1.10.510.10 72 269 2.9E-55 T 09-03-2017 TK78_RS32570 6a64687329803f608f691f5532492590 429 SUPERFAMILY SSF56112 3 310 5.4E-80 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS32570 6a64687329803f608f691f5532492590 429 Gene3D G3DSA:3.30.200.20 3 71 6.6E-23 T 09-03-2017 TK78_RS32570 6a64687329803f608f691f5532492590 429 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 13 36 - T 09-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 TK78_RS32570 6a64687329803f608f691f5532492590 429 Pfam PF00069 Protein kinase domain 7 260 3.2E-54 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS09835 ed87f22eb3b9e7236266bcd7d1a6a664 415 SUPERFAMILY SSF53756 178 358 4.5E-6 T 09-03-2017 TK78_RS09850 c51092e116781bef9b075d2e795ed863 597 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 134 146 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS09850 c51092e116781bef9b075d2e795ed863 597 SUPERFAMILY SSF56112 3 283 4.99E-62 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS09850 c51092e116781bef9b075d2e795ed863 597 Gene3D G3DSA:1.10.510.10 114 335 3.0E-38 T 09-03-2017 TK78_RS09850 c51092e116781bef9b075d2e795ed863 597 Pfam PF00069 Protein kinase domain 7 226 4.6E-41 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS09850 c51092e116781bef9b075d2e795ed863 597 SMART SM00220 6 265 4.0E-48 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS09850 c51092e116781bef9b075d2e795ed863 597 Gene3D G3DSA:3.30.200.20 2 113 1.5E-23 T 09-03-2017 TK78_RS09850 c51092e116781bef9b075d2e795ed863 597 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 12 35 - T 09-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 TK78_RS07680 741957acfce6d56323c0bdcc5c316377 96 Pfam PF00312 Ribosomal protein S15 8 88 2.9E-36 T 09-03-2017 IPR000589 Ribosomal protein S15 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS07680 741957acfce6d56323c0bdcc5c316377 96 SUPERFAMILY SSF47060 3 89 1.91E-34 T 09-03-2017 IPR009068 S15/NS1, RNA-binding TK78_RS07680 741957acfce6d56323c0bdcc5c316377 96 SMART SM01387 8 88 1.1E-50 T 09-03-2017 IPR000589 Ribosomal protein S15 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS07680 741957acfce6d56323c0bdcc5c316377 96 ProDom PD157043 RIBOSOMAL S15 RIBONUCLEOPROTEIN RRNA-BINDING RNA-BINDING 30S CHLOROPLAST S15 MITOCHONDRIAL TYPE 11 88 4.0E-36 T 09-03-2017 TK78_RS07680 741957acfce6d56323c0bdcc5c316377 96 ProSitePatterns PS00362 Ribosomal protein S15 signature. 39 69 - T 09-03-2017 IPR000589 Ribosomal protein S15 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS07680 741957acfce6d56323c0bdcc5c316377 96 Hamap MF_01343_B 30S ribosomal protein S15 [rpsO]. 3 89 22.075 T 09-03-2017 IPR005290 Ribosomal protein S15, bacterial-type GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS07680 741957acfce6d56323c0bdcc5c316377 96 Gene3D G3DSA:1.10.287.10 3 89 2.5E-38 T 09-03-2017 IPR009068 S15/NS1, RNA-binding TK78_RS07680 741957acfce6d56323c0bdcc5c316377 96 TIGRFAM TIGR00952 S15_bact: ribosomal protein uS15 6 89 1.2E-36 T 09-03-2017 IPR005290 Ribosomal protein S15, bacterial-type GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS21480 25a5367982da229b2ce79324b9483f42 1177 Gene3D G3DSA:3.40.50.300 827 980 1.3E-32 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS21480 25a5367982da229b2ce79324b9483f42 1177 SUPERFAMILY SSF143517 1019 1140 2.48E-32 T 09-03-2017 TK78_RS21480 25a5367982da229b2ce79324b9483f42 1177 SMART SM00487 624 814 9.5E-31 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS21480 25a5367982da229b2ce79324b9483f42 1177 Gene3D G3DSA:3.30.2060.10 150 224 2.9E-14 T 09-03-2017 TK78_RS21480 25a5367982da229b2ce79324b9483f42 1177 SUPERFAMILY SSF52540 390 482 1.49E-12 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS21480 25a5367982da229b2ce79324b9483f42 1177 SMART SM00982 1032 1130 2.6E-36 T 09-03-2017 IPR005118 Transcription-repair-coupling factor, C-terminal domain GO:0006281 TK78_RS21480 25a5367982da229b2ce79324b9483f42 1177 SMART SM00490 850 934 7.4E-16 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS21480 25a5367982da229b2ce79324b9483f42 1177 Hamap MF_00969 Transcription-repair-coupling factor [mfd]. 44 1125 28.656 T 09-03-2017 IPR004576 Transcription-repair coupling factor GO:0003684|GO:0005524|GO:0006281 TK78_RS21480 25a5367982da229b2ce79324b9483f42 1177 Pfam PF02559 CarD-like/TRCF domain 500 599 6.9E-31 T 09-03-2017 IPR003711 CarD-like/TRCF domain TK78_RS21480 25a5367982da229b2ce79324b9483f42 1177 Gene3D G3DSA:3.40.50.300 613 810 1.2E-53 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS21480 25a5367982da229b2ce79324b9483f42 1177 Pfam PF00271 Helicase conserved C-terminal domain 834 933 8.0E-15 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS21480 25a5367982da229b2ce79324b9483f42 1177 SUPERFAMILY SSF52540 806 1014 6.76E-45 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS21480 25a5367982da229b2ce79324b9483f42 1177 SUPERFAMILY SSF141259 493 572 4.32E-18 T 09-03-2017 IPR003711 CarD-like/TRCF domain TK78_RS21480 25a5367982da229b2ce79324b9483f42 1177 Pfam PF00270 DEAD/DEAH box helicase 630 791 6.6E-17 T 09-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 TK78_RS21480 25a5367982da229b2ce79324b9483f42 1177 SUPERFAMILY SSF52540 549 807 2.7E-60 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS21480 25a5367982da229b2ce79324b9483f42 1177 Pfam PF03461 TRCF domain 1033 1115 9.5E-24 T 09-03-2017 IPR005118 Transcription-repair-coupling factor, C-terminal domain GO:0006281 TK78_RS21480 25a5367982da229b2ce79324b9483f42 1177 SMART SM01058 499 600 8.1E-47 T 09-03-2017 IPR003711 CarD-like/TRCF domain TK78_RS21480 25a5367982da229b2ce79324b9483f42 1177 TIGRFAM TIGR00580 mfd: transcription-repair coupling factor 167 1104 0.0 T 09-03-2017 IPR004576 Transcription-repair coupling factor GO:0003684|GO:0005524|GO:0006281 TK78_RS21480 25a5367982da229b2ce79324b9483f42 1177 SUPERFAMILY SSF52540 20 367 9.2E-71 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17310 5a12e55f5fda846a98b6dfda67a418d6 323 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 234 255 1.0E-78 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS17310 5a12e55f5fda846a98b6dfda67a418d6 323 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 129 141 1.0E-78 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS17310 5a12e55f5fda846a98b6dfda67a418d6 323 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 107 115 1.0E-78 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS17310 5a12e55f5fda846a98b6dfda67a418d6 323 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 144 168 1.0E-78 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS17310 5a12e55f5fda846a98b6dfda67a418d6 323 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 196 212 1.0E-78 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS17310 5a12e55f5fda846a98b6dfda67a418d6 323 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 40 55 1.0E-78 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS17310 5a12e55f5fda846a98b6dfda67a418d6 323 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 269 287 1.0E-78 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS17310 5a12e55f5fda846a98b6dfda67a418d6 323 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 6 28 1.0E-78 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS17310 5a12e55f5fda846a98b6dfda67a418d6 323 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 61 71 1.0E-78 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS17310 5a12e55f5fda846a98b6dfda67a418d6 323 TIGRFAM TIGR01292 TRX_reduct: thioredoxin-disulfide reductase 6 306 1.2E-119 T 09-03-2017 IPR005982 Thioredoxin reductase GO:0004791|GO:0005737|GO:0019430|GO:0055114 KEGG: 00240+1.8.1.9|KEGG: 00450+1.8.1.9 TK78_RS17310 5a12e55f5fda846a98b6dfda67a418d6 323 SUPERFAMILY SSF51905 5 305 5.89E-51 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS17310 5a12e55f5fda846a98b6dfda67a418d6 323 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 6 295 1.2E-45 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS17310 5a12e55f5fda846a98b6dfda67a418d6 323 Gene3D G3DSA:3.50.50.60 120 240 6.1E-36 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS17310 5a12e55f5fda846a98b6dfda67a418d6 323 Gene3D G3DSA:3.50.50.60 5 119 4.7E-31 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS17310 5a12e55f5fda846a98b6dfda67a418d6 323 ProSitePatterns PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 136 156 - T 09-03-2017 IPR008255 Pyridine nucleotide-disulphide oxidoreductase, class-II, active site GO:0016491|GO:0055114 TK78_RS17310 5a12e55f5fda846a98b6dfda67a418d6 323 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 259 281 3.6E-36 T 09-03-2017 TK78_RS17310 5a12e55f5fda846a98b6dfda67a418d6 323 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 148 166 3.6E-36 T 09-03-2017 TK78_RS17310 5a12e55f5fda846a98b6dfda67a418d6 323 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 7 26 3.6E-36 T 09-03-2017 TK78_RS17310 5a12e55f5fda846a98b6dfda67a418d6 323 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 232 248 3.6E-36 T 09-03-2017 TK78_RS17310 5a12e55f5fda846a98b6dfda67a418d6 323 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 106 124 3.6E-36 T 09-03-2017 TK78_RS29835 4c48ef71da7e111a2a6c006592ad0dcb 397 Gene3D G3DSA:3.90.1260.10 174 394 6.8E-82 T 09-03-2017 IPR024074 Argininosuccinate synthetase, catalytic/multimerisation domain body GO:0004055 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 TK78_RS29835 4c48ef71da7e111a2a6c006592ad0dcb 397 ProSitePatterns PS00565 Argininosuccinate synthase signature 2. 117 128 - T 09-03-2017 IPR018223 Argininosuccinate synthase, conserved site GO:0004055|GO:0005524|GO:0006526 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 TK78_RS29835 4c48ef71da7e111a2a6c006592ad0dcb 397 SUPERFAMILY SSF69864 171 394 3.92E-84 T 09-03-2017 TK78_RS29835 4c48ef71da7e111a2a6c006592ad0dcb 397 Hamap MF_00005 Argininosuccinate synthase [argG]. 2 396 51.819 T 09-03-2017 IPR023434 Argininosuccinate synthase, type 1 subfamily GO:0004055 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 TK78_RS29835 4c48ef71da7e111a2a6c006592ad0dcb 397 SUPERFAMILY SSF52402 3 166 5.95E-42 T 09-03-2017 TK78_RS29835 4c48ef71da7e111a2a6c006592ad0dcb 397 ProSitePatterns PS00564 Argininosuccinate synthase signature 1. 8 16 - T 09-03-2017 IPR018223 Argininosuccinate synthase, conserved site GO:0004055|GO:0005524|GO:0006526 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 TK78_RS29835 4c48ef71da7e111a2a6c006592ad0dcb 397 Gene3D G3DSA:3.40.50.620 3 173 5.3E-56 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS29835 4c48ef71da7e111a2a6c006592ad0dcb 397 Pfam PF00764 Arginosuccinate synthase 6 391 6.4E-186 T 09-03-2017 IPR001518 Argininosuccinate synthase GO:0004055|GO:0005524|GO:0006526 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 TK78_RS29835 4c48ef71da7e111a2a6c006592ad0dcb 397 TIGRFAM TIGR00032 argG: argininosuccinate synthase 4 392 3.4E-146 T 09-03-2017 IPR001518 Argininosuccinate synthase GO:0004055|GO:0005524|GO:0006526 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 TK78_RS09770 72bbbcb8a6cb7014210decfc5efd0aee 429 ProSitePatterns PS01042 Homoserine dehydrogenase signature. 184 206 - T 09-03-2017 IPR019811 Homoserine dehydrogenase, conserved site GO:0006520|GO:0055114 KEGG: 00260+1.1.1.3|KEGG: 00270+1.1.1.3|KEGG: 00300+1.1.1.3 TK78_RS09770 72bbbcb8a6cb7014210decfc5efd0aee 429 Pfam PF03447 Homoserine dehydrogenase, NAD binding domain 12 130 2.9E-21 T 09-03-2017 IPR005106 Aspartate/homoserine dehydrogenase, NAD-binding GO:0016491|GO:0050661|GO:0055114 TK78_RS09770 72bbbcb8a6cb7014210decfc5efd0aee 429 SUPERFAMILY SSF55021 349 421 1.43E-14 T 09-03-2017 TK78_RS09770 72bbbcb8a6cb7014210decfc5efd0aee 429 Pfam PF00742 Homoserine dehydrogenase 138 318 1.5E-66 T 09-03-2017 IPR001342 Homoserine dehydrogenase, catalytic GO:0006520|GO:0055114 KEGG: 00260+1.1.1.3|KEGG: 00270+1.1.1.3|KEGG: 00300+1.1.1.3 TK78_RS09770 72bbbcb8a6cb7014210decfc5efd0aee 429 Gene3D G3DSA:3.40.50.720 3 149 4.7E-48 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS09770 72bbbcb8a6cb7014210decfc5efd0aee 429 PIRSF PIRSF000098 3 429 5.9E-157 T 09-03-2017 IPR016204 Homoserine dehydrogenase GO:0004412|GO:0006520|GO:0055114 KEGG: 00260+1.1.1.3|KEGG: 00270+1.1.1.3|KEGG: 00300+1.1.1.3 TK78_RS09770 72bbbcb8a6cb7014210decfc5efd0aee 429 SUPERFAMILY SSF51735 4 159 4.25E-33 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS09770 72bbbcb8a6cb7014210decfc5efd0aee 429 Pfam PF01842 ACT domain 353 415 8.5E-13 T 09-03-2017 IPR002912 ACT domain GO:0008152|GO:0016597 TK78_RS09770 72bbbcb8a6cb7014210decfc5efd0aee 429 Gene3D G3DSA:3.30.360.10 150 302 1.3E-54 T 09-03-2017 TK78_RS09770 72bbbcb8a6cb7014210decfc5efd0aee 429 SUPERFAMILY SSF55347 138 305 1.18E-52 T 09-03-2017 TK78_RS09770 72bbbcb8a6cb7014210decfc5efd0aee 429 Gene3D G3DSA:3.30.70.260 350 419 7.1E-12 T 09-03-2017 TK78_RS25945 6138348432bf0dc84dbb89ed2a45c952 748 SUPERFAMILY SSF56645 404 614 5.24E-56 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS25945 6138348432bf0dc84dbb89ed2a45c952 748 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 237 376 2.7E-23 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS25945 6138348432bf0dc84dbb89ed2a45c952 748 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 601 743 1.4E-14 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS25945 6138348432bf0dc84dbb89ed2a45c952 748 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 399 490 4.4E-11 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS25945 6138348432bf0dc84dbb89ed2a45c952 748 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 18 106 5.1E-13 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS25945 6138348432bf0dc84dbb89ed2a45c952 748 Gene3D G3DSA:1.10.540.10 17 107 5.5E-13 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS25945 6138348432bf0dc84dbb89ed2a45c952 748 SUPERFAMILY SSF56645 16 223 4.19E-30 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS25945 6138348432bf0dc84dbb89ed2a45c952 748 Gene3D G3DSA:1.10.540.10 406 490 3.7E-14 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS25945 6138348432bf0dc84dbb89ed2a45c952 748 SUPERFAMILY SSF47203 234 377 9.5E-33 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS25945 6138348432bf0dc84dbb89ed2a45c952 748 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 494 589 7.0E-19 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS25945 6138348432bf0dc84dbb89ed2a45c952 748 Gene3D G3DSA:1.20.140.10 234 377 4.2E-32 T 09-03-2017 TK78_RS25945 6138348432bf0dc84dbb89ed2a45c952 748 Gene3D G3DSA:2.40.110.10 144 223 1.6E-5 T 09-03-2017 TK78_RS25945 6138348432bf0dc84dbb89ed2a45c952 748 SUPERFAMILY SSF47203 601 745 1.19E-15 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS25945 6138348432bf0dc84dbb89ed2a45c952 748 Gene3D G3DSA:2.40.110.10 493 591 1.2E-30 T 09-03-2017 TK78_RS25945 6138348432bf0dc84dbb89ed2a45c952 748 Gene3D G3DSA:1.20.140.10 592 748 2.3E-26 T 09-03-2017 TK78_RS17240 b2ea65786ad50aefc895d364127a951f 372 SUPERFAMILY SSF55729 183 365 9.0E-36 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS17240 b2ea65786ad50aefc895d364127a951f 372 Pfam PF02388 FemAB family 265 365 4.2E-17 T 09-03-2017 IPR003447 FemABX peptidyl transferase GO:0009252|GO:0016755 TK78_RS17240 b2ea65786ad50aefc895d364127a951f 372 Pfam PF02388 FemAB family 8 248 2.7E-29 T 09-03-2017 IPR003447 FemABX peptidyl transferase GO:0009252|GO:0016755 TK78_RS17240 b2ea65786ad50aefc895d364127a951f 372 SUPERFAMILY SSF55729 5 114 7.95E-36 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS17240 b2ea65786ad50aefc895d364127a951f 372 SUPERFAMILY SSF55729 143 194 7.95E-36 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS17240 b2ea65786ad50aefc895d364127a951f 372 Gene3D G3DSA:3.40.630.30 148 184 2.8E-56 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS17240 b2ea65786ad50aefc895d364127a951f 372 Gene3D G3DSA:3.40.630.30 1 116 2.8E-56 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS17240 b2ea65786ad50aefc895d364127a951f 372 Gene3D G3DSA:3.40.630.30 185 346 7.0E-52 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS20010 617501bd30187c91185932499c5a138d 503 SUPERFAMILY SSF69075 382 483 7.98E-16 T 09-03-2017 IPR015896 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, dimerisation domain GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188 TK78_RS20010 617501bd30187c91185932499c5a138d 503 SUPERFAMILY SSF51735 182 275 2.54E-16 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS20010 617501bd30187c91185932499c5a138d 503 TIGRFAM TIGR01035 hemA: glutamyl-tRNA reductase 4 277 4.5E-78 T 09-03-2017 IPR000343 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188 TK78_RS20010 617501bd30187c91185932499c5a138d 503 Hamap MF_00087 Glutamyl-tRNA reductase [hemA]. 2 480 25.169 T 09-03-2017 IPR000343 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188 TK78_RS20010 617501bd30187c91185932499c5a138d 503 ProSitePatterns PS00747 Glutamyl-tRNA reductase signature. 99 122 - T 09-03-2017 IPR018214 Glutamyl-tRNA reductase, conserved site GO:0008883|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188 TK78_RS20010 617501bd30187c91185932499c5a138d 503 PIRSF PIRSF000445 1 494 1.2E-123 T 09-03-2017 IPR000343 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188 TK78_RS20010 617501bd30187c91185932499c5a138d 503 Pfam PF05201 Glutamyl-tRNAGlu reductase, N-terminal domain 6 156 2.9E-44 T 09-03-2017 IPR015895 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, N-terminal GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188 TK78_RS20010 617501bd30187c91185932499c5a138d 503 Gene3D G3DSA:3.40.50.720 340 368 6.9E-18 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS20010 617501bd30187c91185932499c5a138d 503 Gene3D G3DSA:3.40.50.720 185 286 6.9E-18 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS20010 617501bd30187c91185932499c5a138d 503 SUPERFAMILY SSF69742 1 158 4.84E-44 T 09-03-2017 IPR015895 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, N-terminal GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188 TK78_RS20010 617501bd30187c91185932499c5a138d 503 Pfam PF00745 Glutamyl-tRNAGlu reductase, dimerisation domain 384 482 2.0E-20 T 09-03-2017 IPR015896 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, dimerisation domain GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188 TK78_RS20010 617501bd30187c91185932499c5a138d 503 Pfam PF01488 Shikimate / quinate 5-dehydrogenase 185 277 1.3E-16 T 09-03-2017 IPR006151 Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase TK78_RS11720 364a65a04a7fb53dd74d1b8327610933 272 SUPERFAMILY SSF51735 15 163 1.27E-26 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS11720 364a65a04a7fb53dd74d1b8327610933 272 Gene3D G3DSA:3.40.50.720 14 167 6.6E-28 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS11720 364a65a04a7fb53dd74d1b8327610933 272 Pfam PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase 15 162 1.2E-19 T 09-03-2017 IPR006115 6-phosphogluconate dehydrogenase, NADP-binding GO:0004616|GO:0055114 TK78_RS11720 364a65a04a7fb53dd74d1b8327610933 272 PIRSF PIRSF000103 7 270 2.5E-31 T 09-03-2017 IPR015815 3-hydroxyisobutyrate dehydrogenase-related GO:0016491|GO:0055114 Reactome: R-HSA-70895 TK78_RS08550 13cd0540d25ae1b1f758215e62cc8cf2 507 PIRSF PIRSF038928 1 487 2.0E-230 T 09-03-2017 IPR024711 Catalase, mono-functional, haem-containing, clades 1 and 3 GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS08550 13cd0540d25ae1b1f758215e62cc8cf2 507 Pfam PF00199 Catalase 10 387 4.7E-185 T 09-03-2017 IPR011614 Catalase core domain GO:0004096|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS08550 13cd0540d25ae1b1f758215e62cc8cf2 507 PRINTS PR00067 Catalase signature 23 46 9.4E-66 T 09-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS08550 13cd0540d25ae1b1f758215e62cc8cf2 507 PRINTS PR00067 Catalase signature 290 317 9.4E-66 T 09-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS08550 13cd0540d25ae1b1f758215e62cc8cf2 507 PRINTS PR00067 Catalase signature 322 348 9.4E-66 T 09-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS08550 13cd0540d25ae1b1f758215e62cc8cf2 507 PRINTS PR00067 Catalase signature 125 143 9.4E-66 T 09-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS08550 13cd0540d25ae1b1f758215e62cc8cf2 507 PRINTS PR00067 Catalase signature 106 123 9.4E-66 T 09-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS08550 13cd0540d25ae1b1f758215e62cc8cf2 507 PRINTS PR00067 Catalase signature 85 103 9.4E-66 T 09-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS08550 13cd0540d25ae1b1f758215e62cc8cf2 507 ProSitePatterns PS00437 Catalase proximal heme-ligand signature. 335 343 - T 09-03-2017 IPR002226 Catalase haem-binding site GO:0020037 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS08550 13cd0540d25ae1b1f758215e62cc8cf2 507 SUPERFAMILY SSF56634 4 490 4.58E-201 T 09-03-2017 IPR020835 Catalase-like domain GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS08550 13cd0540d25ae1b1f758215e62cc8cf2 507 Pfam PF06628 Catalase-related immune-responsive 419 481 1.3E-16 T 09-03-2017 IPR010582 Catalase immune-responsive domain KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS08550 13cd0540d25ae1b1f758215e62cc8cf2 507 SMART SM01060 10 391 6.6E-277 T 09-03-2017 IPR011614 Catalase core domain GO:0004096|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS08550 13cd0540d25ae1b1f758215e62cc8cf2 507 Gene3D G3DSA:2.40.180.10 4 359 2.1E-175 T 09-03-2017 IPR011614 Catalase core domain GO:0004096|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS08550 13cd0540d25ae1b1f758215e62cc8cf2 507 ProSitePatterns PS00438 Catalase proximal active site signature. 46 62 - T 09-03-2017 IPR024708 Catalase active site GO:0004096 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS27515 24ea1e7bc7810083f7e773741f643602 252 ProSitePatterns PS00135 Serine proteases, trypsin family, serine active site. 195 206 - T 09-03-2017 IPR033116 Serine proteases, trypsin family, serine active site TK78_RS27515 24ea1e7bc7810083f7e773741f643602 252 Pfam PF00089 Trypsin 31 242 1.3E-51 T 09-03-2017 IPR001254 Serine proteases, trypsin domain GO:0004252|GO:0006508 TK78_RS27515 24ea1e7bc7810083f7e773741f643602 252 SMART SM00020 30 245 1.5E-66 T 09-03-2017 IPR001254 Serine proteases, trypsin domain GO:0004252|GO:0006508 TK78_RS27515 24ea1e7bc7810083f7e773741f643602 252 Gene3D G3DSA:2.40.10.10 31 60 4.7E-14 T 09-03-2017 TK78_RS27515 24ea1e7bc7810083f7e773741f643602 252 ProSitePatterns PS00134 Serine proteases, trypsin family, histidine active site. 63 68 - T 09-03-2017 IPR018114 Serine proteases, trypsin family, histidine active site GO:0004252|GO:0006508 TK78_RS27515 24ea1e7bc7810083f7e773741f643602 252 PRINTS PR00722 Chymotrypsin serine protease family (S1) signature 194 206 1.7E-12 T 09-03-2017 IPR001314 Peptidase S1A, chymotrypsin family GO:0004252|GO:0006508 TK78_RS27515 24ea1e7bc7810083f7e773741f643602 252 PRINTS PR00722 Chymotrypsin serine protease family (S1) signature 53 68 1.7E-12 T 09-03-2017 IPR001314 Peptidase S1A, chymotrypsin family GO:0004252|GO:0006508 TK78_RS27515 24ea1e7bc7810083f7e773741f643602 252 PRINTS PR00722 Chymotrypsin serine protease family (S1) signature 108 122 1.7E-12 T 09-03-2017 IPR001314 Peptidase S1A, chymotrypsin family GO:0004252|GO:0006508 TK78_RS27515 24ea1e7bc7810083f7e773741f643602 252 SUPERFAMILY SSF50494 15 242 2.16E-62 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS27515 24ea1e7bc7810083f7e773741f643602 252 Gene3D G3DSA:2.40.10.10 61 243 1.2E-49 T 09-03-2017 TK78_RS02405 735bf22311b188c453bb4ce597af1eb2 362 SUPERFAMILY SSF103481 22 112 4.45E-7 T 09-03-2017 TK78_RS02405 735bf22311b188c453bb4ce597af1eb2 362 Pfam PF05653 Magnesium transporter NIPA 34 108 2.4E-7 T 09-03-2017 IPR008521 Magnesium transporter NIPA GO:0015095|GO:0015693|GO:0016021 Reactome: R-HSA-5223345 TK78_RS06340 ed7828471d70c2c5098379d86c264b86 117 Pfam PF03334 Na+/H+ antiporter subunit 15 94 2.0E-26 T 09-03-2017 IPR005133 Na+/H+ antiporter subunit G GO:0005451|GO:0015672|GO:0015992 TK78_RS06340 ed7828471d70c2c5098379d86c264b86 117 TIGRFAM TIGR01300 CPA3_mnhG_phaG: monovalent cation/proton antiporter, MnhG/PhaG subunit 15 101 2.0E-27 T 09-03-2017 IPR005133 Na+/H+ antiporter subunit G GO:0005451|GO:0015672|GO:0015992 TK78_RS14915 77ec66d9e4c836100ca0f220137116c3 316 Pfam PF13432 Tetratricopeptide repeat 195 249 2.1E-7 T 09-03-2017 TK78_RS14915 77ec66d9e4c836100ca0f220137116c3 316 SUPERFAMILY SSF48452 60 89 1.0E-12 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS14915 77ec66d9e4c836100ca0f220137116c3 316 SUPERFAMILY SSF48452 151 279 1.0E-12 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS14915 77ec66d9e4c836100ca0f220137116c3 316 Gene3D G3DSA:1.25.40.10 11 42 3.0E-15 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS14915 77ec66d9e4c836100ca0f220137116c3 316 Gene3D G3DSA:1.25.40.10 151 286 3.0E-15 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS14915 77ec66d9e4c836100ca0f220137116c3 316 SMART SM00028 182 215 1.9 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS14915 77ec66d9e4c836100ca0f220137116c3 316 SMART SM00028 216 249 33.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS06030 02bdcb6b22696d1029e5862f62b378a3 1293 Gene3D G3DSA:2.60.120.260 115 239 1.2E-14 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS06030 02bdcb6b22696d1029e5862f62b378a3 1293 Gene3D G3DSA:2.60.120.260 1212 1291 4.5E-6 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS06030 02bdcb6b22696d1029e5862f62b378a3 1293 Gene3D G3DSA:3.30.2080.10 1019 1168 1.7E-58 T 09-03-2017 TK78_RS06030 02bdcb6b22696d1029e5862f62b378a3 1293 Pfam PF07971 Glycosyl hydrolase family 92 634 1157 4.7E-139 T 09-03-2017 IPR012939 Glycosyl hydrolase family 92 TK78_RS06030 02bdcb6b22696d1029e5862f62b378a3 1293 SUPERFAMILY SSF48208 658 1140 1.21E-14 T 09-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 TK78_RS06030 02bdcb6b22696d1029e5862f62b378a3 1293 Gene3D G3DSA:1.20.1610.10 849 1018 5.7E-48 T 09-03-2017 TK78_RS06030 02bdcb6b22696d1029e5862f62b378a3 1293 Pfam PF00754 F5/8 type C domain 116 229 8.2E-12 T 09-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain TK78_RS06030 02bdcb6b22696d1029e5862f62b378a3 1293 TIGRFAM TIGR01180 aman2_put: putative alpha-1,2-mannosidase 422 1159 3.5E-134 T 09-03-2017 IPR005887 Alpha-1,2-mannosidase, putative TK78_RS06030 02bdcb6b22696d1029e5862f62b378a3 1293 Gene3D G3DSA:2.70.98.10 423 718 1.6E-76 T 09-03-2017 IPR014718 Glycoside hydrolase-type carbohydrate-binding GO:0003824|GO:0005975|GO:0030246 TK78_RS06030 02bdcb6b22696d1029e5862f62b378a3 1293 Gene3D G3DSA:1.20.1050.60 757 845 2.6E-28 T 09-03-2017 TK78_RS06030 02bdcb6b22696d1029e5862f62b378a3 1293 SUPERFAMILY SSF49785 117 229 7.8E-13 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS12490 47302d525b37fd522aed7533c08183f0 517 Gene3D G3DSA:3.40.50.1380 6 188 1.6E-76 T 09-03-2017 IPR011607 Methylglyoxal synthase-like domain TK78_RS12490 47302d525b37fd522aed7533c08183f0 517 Gene3D G3DSA:3.40.140.20 364 507 7.2E-51 T 09-03-2017 IPR024051 AICAR transformylase domain KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TK78_RS12490 47302d525b37fd522aed7533c08183f0 517 Gene3D G3DSA:3.40.140.20 243 360 7.1E-45 T 09-03-2017 IPR024051 AICAR transformylase domain KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TK78_RS12490 47302d525b37fd522aed7533c08183f0 517 SUPERFAMILY SSF53927 214 517 1.0E-116 T 09-03-2017 IPR016193 Cytidine deaminase-like GO:0003824 TK78_RS12490 47302d525b37fd522aed7533c08183f0 517 SUPERFAMILY SSF52335 7 195 4.4E-64 T 09-03-2017 IPR011607 Methylglyoxal synthase-like domain TK78_RS12490 47302d525b37fd522aed7533c08183f0 517 TIGRFAM TIGR00355 purH: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 8 517 1.0E-171 T 09-03-2017 IPR002695 AICARFT/IMPCHase bienzyme GO:0003937|GO:0004643|GO:0006164 KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TK78_RS12490 47302d525b37fd522aed7533c08183f0 517 SMART SM00851 19 133 2.8E-49 T 09-03-2017 IPR011607 Methylglyoxal synthase-like domain TK78_RS12490 47302d525b37fd522aed7533c08183f0 517 Pfam PF01808 AICARFT/IMPCHase bienzyme 138 450 5.8E-113 T 09-03-2017 IPR002695 AICARFT/IMPCHase bienzyme GO:0003937|GO:0004643|GO:0006164 KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TK78_RS12490 47302d525b37fd522aed7533c08183f0 517 Pfam PF02142 MGS-like domain 20 132 1.0E-23 T 09-03-2017 IPR011607 Methylglyoxal synthase-like domain TK78_RS12490 47302d525b37fd522aed7533c08183f0 517 SMART SM00798 138 451 3.5E-183 T 09-03-2017 IPR002695 AICARFT/IMPCHase bienzyme GO:0003937|GO:0004643|GO:0006164 KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TK78_RS12490 47302d525b37fd522aed7533c08183f0 517 PIRSF PIRSF000414 1 517 1.0E-196 T 09-03-2017 IPR002695 AICARFT/IMPCHase bienzyme GO:0003937|GO:0004643|GO:0006164 KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TK78_RS12490 47302d525b37fd522aed7533c08183f0 517 Hamap MF_00139 Bifunctional purine biosynthesis protein PurH [purH]. 7 517 42.293 T 09-03-2017 IPR002695 AICARFT/IMPCHase bienzyme GO:0003937|GO:0004643|GO:0006164 KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TK78_RS33160 2bbc65e836040e590f01614fa2105888 355 Gene3D G3DSA:2.70.98.10 4 349 2.9E-118 T 09-03-2017 IPR014718 Glycoside hydrolase-type carbohydrate-binding GO:0003824|GO:0005975|GO:0030246 TK78_RS33160 2bbc65e836040e590f01614fa2105888 355 PIRSF PIRSF005096 1 351 4.7E-116 T 09-03-2017 IPR015443 Aldose 1-epimerase GO:0016853|GO:0019318 KEGG: 00010+5.1.3.3|KEGG: 00052+5.1.3.3|MetaCyc: PWY-6317 TK78_RS33160 2bbc65e836040e590f01614fa2105888 355 Pfam PF01263 Aldose 1-epimerase 19 346 6.9E-85 T 09-03-2017 IPR008183 Aldose 1-/Glucose-6-phosphate 1-epimerase GO:0005975|GO:0016853 TK78_RS33160 2bbc65e836040e590f01614fa2105888 355 SUPERFAMILY SSF74650 7 349 1.57E-109 T 09-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 TK78_RS16530 6cb83b8e16f33f07af28b87669494e1d 183 TIGRFAM TIGR03941 tRNA_deam_assoc: putative tRNA adenosine deaminase-associated protein 2 182 3.6E-26 T 09-03-2017 IPR023869 tRNA adenosine deaminase-associated protein, putative TK78_RS30850 8a50debcc7b82b19734de40202e8fac6 323 Pfam PF13280 WYL domain 147 315 2.9E-26 T 09-03-2017 IPR026881 WYL domain TK78_RS30850 8a50debcc7b82b19734de40202e8fac6 323 Gene3D G3DSA:1.10.10.10 1 61 1.6E-13 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS30850 8a50debcc7b82b19734de40202e8fac6 323 SUPERFAMILY SSF46785 2 57 3.22E-10 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS30850 8a50debcc7b82b19734de40202e8fac6 323 Pfam PF08279 HTH domain 10 57 3.1E-15 T 09-03-2017 IPR013196 Helix-turn-helix, type 11 TK78_RS33895 54ddbba10fd6b4d215436565cff9b322 746 Pfam PF02310 B12 binding domain 615 724 9.8E-14 T 09-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 TK78_RS33895 54ddbba10fd6b4d215436565cff9b322 746 TIGRFAM TIGR00640 acid_CoA_mut_C: methylmalonyl-CoA mutase C-terminal domain 612 739 6.8E-62 T 09-03-2017 IPR006159 Methylmalonyl-CoA mutase, C-terminal GO:0016853 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 TK78_RS33895 54ddbba10fd6b4d215436565cff9b322 746 TIGRFAM TIGR00641 acid_CoA_mut_N: methylmalonyl-CoA mutase N-terminal domain 54 580 2.0E-280 T 09-03-2017 IPR006098 Methylmalonyl-CoA mutase, alpha chain, catalytic GO:0004494|GO:0008152|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 TK78_RS33895 54ddbba10fd6b4d215436565cff9b322 746 Gene3D G3DSA:3.20.20.240 54 520 1.6E-210 T 09-03-2017 IPR014348 Cobalamin (vitamin B12)-dependent enzyme, catalytic subdomain GO:0008152|GO:0016866|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 TK78_RS33895 54ddbba10fd6b4d215436565cff9b322 746 Gene3D G3DSA:3.40.50.280 579 738 1.3E-70 T 09-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 TK78_RS33895 54ddbba10fd6b4d215436565cff9b322 746 ProSitePatterns PS00544 Methylmalonyl-CoA mutase signature. 397 422 - T 09-03-2017 IPR006099 Methylmalonyl-CoA mutase, alpha/beta chain, catalytic GO:0008152|GO:0016866|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 TK78_RS33895 54ddbba10fd6b4d215436565cff9b322 746 Pfam PF01642 Methylmalonyl-CoA mutase 55 573 1.2E-236 T 09-03-2017 IPR006099 Methylmalonyl-CoA mutase, alpha/beta chain, catalytic GO:0008152|GO:0016866|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 TK78_RS33895 54ddbba10fd6b4d215436565cff9b322 746 SUPERFAMILY SSF52242 578 738 7.2E-58 T 09-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 TK78_RS33895 54ddbba10fd6b4d215436565cff9b322 746 SUPERFAMILY SSF51703 32 575 3.14E-223 T 09-03-2017 IPR016176 Cobalamin (vitamin B12)-dependent enzyme, catalytic GO:0003824|GO:0008152|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 TK78_RS18670 909bdde99ff2ee0c7f3604e1f672d2ed 749 Pfam PF13090 Polyphosphate kinase C-terminal domain 390 737 1.0E-152 T 09-03-2017 IPR025200 Polyphosphate kinase C-terminal domain KEGG: 00190+2.7.4.1 TK78_RS18670 909bdde99ff2ee0c7f3604e1f672d2ed 749 SUPERFAMILY SSF56024 561 742 1.7E-64 T 09-03-2017 TK78_RS18670 909bdde99ff2ee0c7f3604e1f672d2ed 749 Gene3D G3DSA:3.30.870.10 561 743 3.5E-70 T 09-03-2017 TK78_RS18670 909bdde99ff2ee0c7f3604e1f672d2ed 749 SUPERFAMILY SSF140356 66 169 2.49E-34 T 09-03-2017 IPR025198 Polyphosphate kinase N-terminal domain KEGG: 00190+2.7.4.1 TK78_RS18670 909bdde99ff2ee0c7f3604e1f672d2ed 749 SUPERFAMILY SSF143724 172 368 5.69E-64 T 09-03-2017 TK78_RS18670 909bdde99ff2ee0c7f3604e1f672d2ed 749 SUPERFAMILY SSF56024 386 558 4.71E-56 T 09-03-2017 TK78_RS18670 909bdde99ff2ee0c7f3604e1f672d2ed 749 Pfam PF02503 Polyphosphate kinase middle domain 184 374 1.2E-65 T 09-03-2017 IPR024953 Polyphosphate kinase middle domain KEGG: 00190+2.7.4.1 TK78_RS18670 909bdde99ff2ee0c7f3604e1f672d2ed 749 PIRSF PIRSF015589 50 749 2.6E-281 T 09-03-2017 IPR003414 Polyphosphate kinase GO:0006799|GO:0008976|GO:0009358 KEGG: 00190+2.7.4.1 TK78_RS18670 909bdde99ff2ee0c7f3604e1f672d2ed 749 Gene3D G3DSA:3.30.870.10 385 560 5.8E-79 T 09-03-2017 TK78_RS18670 909bdde99ff2ee0c7f3604e1f672d2ed 749 Hamap MF_00347 Polyphosphate kinase [ppk]. 66 742 33.89 T 09-03-2017 IPR003414 Polyphosphate kinase GO:0006799|GO:0008976|GO:0009358 KEGG: 00190+2.7.4.1 TK78_RS18670 909bdde99ff2ee0c7f3604e1f672d2ed 749 TIGRFAM TIGR03705 poly_P_kin: polyphosphate kinase 1 68 738 8.1E-248 T 09-03-2017 IPR003414 Polyphosphate kinase GO:0006799|GO:0008976|GO:0009358 KEGG: 00190+2.7.4.1 TK78_RS18670 909bdde99ff2ee0c7f3604e1f672d2ed 749 Pfam PF13089 Polyphosphate kinase N-terminal domain 69 175 2.4E-35 T 09-03-2017 IPR025198 Polyphosphate kinase N-terminal domain KEGG: 00190+2.7.4.1 TK78_RS18670 909bdde99ff2ee0c7f3604e1f672d2ed 749 Gene3D G3DSA:3.30.1840.10 171 356 9.8E-72 T 09-03-2017 IPR024953 Polyphosphate kinase middle domain KEGG: 00190+2.7.4.1 TK78_RS02780 d610af2e293151b506aa62467cb11df3 240 Gene3D G3DSA:3.90.79.10 13 149 4.4E-39 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS02780 d610af2e293151b506aa62467cb11df3 240 Pfam PF00293 NUDIX domain 22 140 9.6E-13 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS02780 d610af2e293151b506aa62467cb11df3 240 ProSitePatterns PS00893 Nudix box signature. 51 72 - T 09-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 TK78_RS02780 d610af2e293151b506aa62467cb11df3 240 Gene3D G3DSA:1.10.10.10 152 226 6.2E-24 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS02780 d610af2e293151b506aa62467cb11df3 240 SUPERFAMILY SSF55811 15 156 2.17E-28 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS02780 d610af2e293151b506aa62467cb11df3 240 SUPERFAMILY SSF46785 160 230 7.48E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS30345 48388edf5fcc538bbb4a55d0b7b58633 90 SMART SM01409 18 82 2.2E-14 T 09-03-2017 IPR006110 RNA polymerase, subunit omega/K/RPB6 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167161|Reactome: R-HSA-167162|Reactome: R-HSA-167172|Reactome: R-HSA-167200|Reactome: R-HSA-167238|Reactome: R-HSA-167242|Reactome: R-HSA-167243|Reactome: R-HSA-167246|Reactome: R-HSA-167287|Reactome: R-HSA-167290|Reactome: R-HSA-168325|Reactome: R-HSA-1834949|Reactome: R-HSA-203927|Reactome: R-HSA-427413|Reactome: R-HSA-452723|Reactome: R-HSA-5250924|Reactome: R-HSA-5578749|Reactome: R-HSA-5601884|Reactome: R-HSA-5617472|Reactome: R-HSA-674695|Reactome: R-HSA-6781823|Reactome: R-HSA-6781827|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210|Reactome: R-HSA-6796648|Reactome: R-HSA-6803529|Reactome: R-HSA-6807505|Reactome: R-HSA-72086|Reactome: R-HSA-72163|Reactome: R-HSA-72165|Reactome: R-HSA-72203|Reactome: R-HSA-73762|Reactome: R-HSA-73772|Reactome: R-HSA-73776|Reactome: R-HSA-73777|Reactome: R-HSA-73779|Reactome: R-HSA-73780|Reactome: R-HSA-73863|Reactome: R-HSA-73980|Reactome: R-HSA-749476|Reactome: R-HSA-75953|Reactome: R-HSA-75955|Reactome: R-HSA-76042|Reactome: R-HSA-76061|Reactome: R-HSA-76066|Reactome: R-HSA-76071|Reactome: R-HSA-77075|Reactome: R-HSA-8851708 TK78_RS30345 48388edf5fcc538bbb4a55d0b7b58633 90 Gene3D G3DSA:3.90.940.10 11 85 5.3E-34 T 09-03-2017 IPR012293 RNA polymerase subunit, RPB6/omega GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167161|Reactome: R-HSA-167162|Reactome: R-HSA-167172|Reactome: R-HSA-167200|Reactome: R-HSA-167238|Reactome: R-HSA-167242|Reactome: R-HSA-167243|Reactome: R-HSA-167246|Reactome: R-HSA-167287|Reactome: R-HSA-167290|Reactome: R-HSA-168325|Reactome: R-HSA-1834949|Reactome: R-HSA-203927|Reactome: R-HSA-427413|Reactome: R-HSA-452723|Reactome: R-HSA-5250924|Reactome: R-HSA-5578749|Reactome: R-HSA-5601884|Reactome: R-HSA-5617472|Reactome: R-HSA-674695|Reactome: R-HSA-6781823|Reactome: R-HSA-6781827|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210|Reactome: R-HSA-6796648|Reactome: R-HSA-6803529|Reactome: R-HSA-6807505|Reactome: R-HSA-72086|Reactome: R-HSA-72163|Reactome: R-HSA-72165|Reactome: R-HSA-72203|Reactome: R-HSA-73762|Reactome: R-HSA-73772|Reactome: R-HSA-73776|Reactome: R-HSA-73777|Reactome: R-HSA-73779|Reactome: R-HSA-73780|Reactome: R-HSA-73863|Reactome: R-HSA-73980|Reactome: R-HSA-749476|Reactome: R-HSA-75953|Reactome: R-HSA-75955|Reactome: R-HSA-76042|Reactome: R-HSA-76061|Reactome: R-HSA-76066|Reactome: R-HSA-76071|Reactome: R-HSA-77075|Reactome: R-HSA-8851708 TK78_RS30345 48388edf5fcc538bbb4a55d0b7b58633 90 Hamap MF_00366 DNA-directed RNA polymerase subunit omega [rpoZ]. 11 83 14.945 T 09-03-2017 IPR003716 DNA-directed RNA polymerase, omega subunit GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS30345 48388edf5fcc538bbb4a55d0b7b58633 90 TIGRFAM TIGR00690 rpoZ: DNA-directed RNA polymerase, omega subunit 12 80 8.5E-22 T 09-03-2017 IPR003716 DNA-directed RNA polymerase, omega subunit GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS30345 48388edf5fcc538bbb4a55d0b7b58633 90 Pfam PF01192 RNA polymerase Rpb6 18 80 9.7E-15 T 09-03-2017 IPR006110 RNA polymerase, subunit omega/K/RPB6 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167161|Reactome: R-HSA-167162|Reactome: R-HSA-167172|Reactome: R-HSA-167200|Reactome: R-HSA-167238|Reactome: R-HSA-167242|Reactome: R-HSA-167243|Reactome: R-HSA-167246|Reactome: R-HSA-167287|Reactome: R-HSA-167290|Reactome: R-HSA-168325|Reactome: R-HSA-1834949|Reactome: R-HSA-203927|Reactome: R-HSA-427413|Reactome: R-HSA-452723|Reactome: R-HSA-5250924|Reactome: R-HSA-5578749|Reactome: R-HSA-5601884|Reactome: R-HSA-5617472|Reactome: R-HSA-674695|Reactome: R-HSA-6781823|Reactome: R-HSA-6781827|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210|Reactome: R-HSA-6796648|Reactome: R-HSA-6803529|Reactome: R-HSA-6807505|Reactome: R-HSA-72086|Reactome: R-HSA-72163|Reactome: R-HSA-72165|Reactome: R-HSA-72203|Reactome: R-HSA-73762|Reactome: R-HSA-73772|Reactome: R-HSA-73776|Reactome: R-HSA-73777|Reactome: R-HSA-73779|Reactome: R-HSA-73780|Reactome: R-HSA-73863|Reactome: R-HSA-73980|Reactome: R-HSA-749476|Reactome: R-HSA-75953|Reactome: R-HSA-75955|Reactome: R-HSA-76042|Reactome: R-HSA-76061|Reactome: R-HSA-76066|Reactome: R-HSA-76071|Reactome: R-HSA-77075|Reactome: R-HSA-8851708 TK78_RS30345 48388edf5fcc538bbb4a55d0b7b58633 90 SUPERFAMILY SSF63562 11 86 1.06E-24 T 09-03-2017 IPR006110 RNA polymerase, subunit omega/K/RPB6 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167161|Reactome: R-HSA-167162|Reactome: R-HSA-167172|Reactome: R-HSA-167200|Reactome: R-HSA-167238|Reactome: R-HSA-167242|Reactome: R-HSA-167243|Reactome: R-HSA-167246|Reactome: R-HSA-167287|Reactome: R-HSA-167290|Reactome: R-HSA-168325|Reactome: R-HSA-1834949|Reactome: R-HSA-203927|Reactome: R-HSA-427413|Reactome: R-HSA-452723|Reactome: R-HSA-5250924|Reactome: R-HSA-5578749|Reactome: R-HSA-5601884|Reactome: R-HSA-5617472|Reactome: R-HSA-674695|Reactome: R-HSA-6781823|Reactome: R-HSA-6781827|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210|Reactome: R-HSA-6796648|Reactome: R-HSA-6803529|Reactome: R-HSA-6807505|Reactome: R-HSA-72086|Reactome: R-HSA-72163|Reactome: R-HSA-72165|Reactome: R-HSA-72203|Reactome: R-HSA-73762|Reactome: R-HSA-73772|Reactome: R-HSA-73776|Reactome: R-HSA-73777|Reactome: R-HSA-73779|Reactome: R-HSA-73780|Reactome: R-HSA-73863|Reactome: R-HSA-73980|Reactome: R-HSA-749476|Reactome: R-HSA-75953|Reactome: R-HSA-75955|Reactome: R-HSA-76042|Reactome: R-HSA-76061|Reactome: R-HSA-76066|Reactome: R-HSA-76071|Reactome: R-HSA-77075|Reactome: R-HSA-8851708 TK78_RS00620 b0268e87b27733d8caa4b8186466b3f7 234 SMART SM00862 145 217 2.4E-19 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS00620 b0268e87b27733d8caa4b8186466b3f7 234 Gene3D G3DSA:1.10.10.10 126 219 8.1E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS00620 b0268e87b27733d8caa4b8186466b3f7 234 Pfam PF00072 Response regulator receiver domain 3 112 6.9E-22 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS00620 b0268e87b27733d8caa4b8186466b3f7 234 Pfam PF00486 Transcriptional regulatory protein, C terminal 147 216 1.6E-18 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS00620 b0268e87b27733d8caa4b8186466b3f7 234 SMART SM00448 1 112 8.5E-30 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS00620 b0268e87b27733d8caa4b8186466b3f7 234 SUPERFAMILY SSF52172 1 166 4.7E-34 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS00620 b0268e87b27733d8caa4b8186466b3f7 234 Gene3D G3DSA:3.40.50.2300 1 125 2.3E-31 T 09-03-2017 TK78_RS18385 02d974248af35fe346863219b4b4b731 286 SUPERFAMILY SSF51621 6 282 1.08E-93 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS18385 02d974248af35fe346863219b4b4b731 286 ProSitePatterns PS00161 Isocitrate lyase signature. 120 125 - T 09-03-2017 IPR018523 Isocitrate lyase/phosphorylmutase, conserved site GO:0003824|GO:0008152 TK78_RS18385 02d974248af35fe346863219b4b4b731 286 Gene3D G3DSA:3.20.20.60 7 281 1.8E-92 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS18385 02d974248af35fe346863219b4b4b731 286 Pfam PF13714 Phosphoenolpyruvate phosphomutase 11 253 1.2E-57 T 09-03-2017 TK78_RS25595 a83614d2238b933f59036e19d4d3391e 910 TIGRFAM TIGR00759 aceE: pyruvate dehydrogenase (acetyl-transferring), homodimeric type 19 902 0.0 T 09-03-2017 IPR004660 2-oxo-acid dehydrogenase E1 component homodimeric type GO:0016491|GO:0055114 KEGG: 00010+1.2.4.1|KEGG: 00020+1.2.4.1|KEGG: 00620+1.2.4.1 TK78_RS25595 a83614d2238b933f59036e19d4d3391e 910 SUPERFAMILY SSF52518 70 482 7.94E-126 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS25595 a83614d2238b933f59036e19d4d3391e 910 Gene3D G3DSA:3.40.50.920 725 897 6.0E-69 T 09-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 TK78_RS25595 a83614d2238b933f59036e19d4d3391e 910 Gene3D G3DSA:3.40.50.970 70 483 2.7E-147 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS25595 a83614d2238b933f59036e19d4d3391e 910 Gene3D G3DSA:3.40.50.970 488 721 5.9E-110 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS25595 a83614d2238b933f59036e19d4d3391e 910 SUPERFAMILY SSF52922 720 895 9.77E-54 T 09-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 TK78_RS25595 a83614d2238b933f59036e19d4d3391e 910 SUPERFAMILY SSF52518 488 717 1.12E-86 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS25595 a83614d2238b933f59036e19d4d3391e 910 PIRSF PIRSF000156 10 905 0.0 T 09-03-2017 IPR004660 2-oxo-acid dehydrogenase E1 component homodimeric type GO:0016491|GO:0055114 KEGG: 00010+1.2.4.1|KEGG: 00020+1.2.4.1|KEGG: 00620+1.2.4.1 TK78_RS25595 a83614d2238b933f59036e19d4d3391e 910 Pfam PF00456 Transketolase, thiamine diphosphate binding domain 150 307 8.5E-8 T 09-03-2017 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 TK78_RS04325 a31932fd643be8668de2f3ac047b7c78 439 SUPERFAMILY SSF53474 60 169 3.93E-21 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04325 a31932fd643be8668de2f3ac047b7c78 439 SUPERFAMILY SSF53474 170 288 2.78E-46 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04325 a31932fd643be8668de2f3ac047b7c78 439 SUPERFAMILY SSF53474 316 388 2.78E-46 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04325 a31932fd643be8668de2f3ac047b7c78 439 Pfam PF10503 Esterase PHB depolymerase 88 289 1.6E-50 T 09-03-2017 IPR010126 Esterase, PHB depolymerase GO:0005576|GO:0016787 TK78_RS04325 a31932fd643be8668de2f3ac047b7c78 439 TIGRFAM TIGR01840 esterase_phb: esterase, PHB depolymerase family 85 296 5.2E-72 T 09-03-2017 IPR010126 Esterase, PHB depolymerase GO:0005576|GO:0016787 TK78_RS04325 a31932fd643be8668de2f3ac047b7c78 439 Gene3D G3DSA:3.40.50.1820 53 346 4.8E-51 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS06675 7b66c18908d6925c2468e4c254790d4d 213 Pfam PF00547 Urease, gamma subunit 1 73 7.5E-13 T 09-03-2017 IPR002026 Urease, gamma/gamma-beta subunit GO:0016151|GO:0043419 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 TK78_RS06675 7b66c18908d6925c2468e4c254790d4d 213 SUPERFAMILY SSF54111 1 74 1.31E-11 T 09-03-2017 IPR002026 Urease, gamma/gamma-beta subunit GO:0016151|GO:0043419 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 TK78_RS06675 7b66c18908d6925c2468e4c254790d4d 213 Gene3D G3DSA:3.30.280.10 1 72 2.1E-12 T 09-03-2017 IPR002026 Urease, gamma/gamma-beta subunit GO:0016151|GO:0043419 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 TK78_RS24685 89a6105722dda35b5b74f2654ef0677c 88 TIGRFAM TIGR00029 S20: ribosomal protein bS20 2 85 7.5E-22 T 09-03-2017 IPR002583 Ribosomal protein S20 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS24685 89a6105722dda35b5b74f2654ef0677c 88 Hamap MF_00500 30S ribosomal protein S20 [rpsT]. 1 85 16.604 T 09-03-2017 IPR002583 Ribosomal protein S20 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS24685 89a6105722dda35b5b74f2654ef0677c 88 Gene3D G3DSA:1.20.58.110 3 86 7.2E-28 T 09-03-2017 IPR002583 Ribosomal protein S20 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS24685 89a6105722dda35b5b74f2654ef0677c 88 SUPERFAMILY SSF46992 3 86 8.89E-27 T 09-03-2017 IPR002583 Ribosomal protein S20 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS24685 89a6105722dda35b5b74f2654ef0677c 88 Pfam PF01649 Ribosomal protein S20 2 83 2.1E-26 T 09-03-2017 IPR002583 Ribosomal protein S20 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS24685 89a6105722dda35b5b74f2654ef0677c 88 ProDom PD004231 RIBOSOMAL S20 30S RRNA-BINDING RNA-BINDING RIBONUCLEOPROTEIN S20P SUBUNIT CHLOROPLAST DIRECT 14 68 3.0E-19 T 09-03-2017 IPR002583 Ribosomal protein S20 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13460 d01ab41b43739856dcbf474d0738ffd2 326 SUPERFAMILY SSF103481 51 147 9.02E-13 T 09-03-2017 TK78_RS13460 d01ab41b43739856dcbf474d0738ffd2 326 Pfam PF00892 EamA-like transporter family 10 144 1.3E-10 T 09-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 TK78_RS13460 d01ab41b43739856dcbf474d0738ffd2 326 SUPERFAMILY SSF103481 191 287 6.67E-9 T 09-03-2017 TK78_RS13460 d01ab41b43739856dcbf474d0738ffd2 326 TIGRFAM TIGR00688 rarD: protein RarD 9 259 7.0E-64 T 09-03-2017 IPR004626 RarD protein GO:0005215|GO:0005887|GO:0006810 TK78_RS03380 fa28ba3539b79ca6c44ee98d9d5163c2 778 Gene3D G3DSA:1.20.1580.10 531 649 8.3E-34 T 09-03-2017 TK78_RS03380 fa28ba3539b79ca6c44ee98d9d5163c2 778 Gene3D G3DSA:1.20.1580.10 272 342 9.5E-29 T 09-03-2017 TK78_RS03380 fa28ba3539b79ca6c44ee98d9d5163c2 778 Gene3D G3DSA:1.20.1580.10 109 167 9.5E-29 T 09-03-2017 TK78_RS03380 fa28ba3539b79ca6c44ee98d9d5163c2 778 Pfam PF00005 ABC transporter 483 686 6.2E-13 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS03380 fa28ba3539b79ca6c44ee98d9d5163c2 778 Gene3D G3DSA:3.40.50.300 343 459 8.0E-50 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03380 fa28ba3539b79ca6c44ee98d9d5163c2 778 Gene3D G3DSA:3.40.50.300 19 68 8.0E-50 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03380 fa28ba3539b79ca6c44ee98d9d5163c2 778 Gene3D G3DSA:3.40.50.300 477 528 4.0E-57 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03380 fa28ba3539b79ca6c44ee98d9d5163c2 778 Gene3D G3DSA:3.40.50.300 650 764 4.0E-57 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03380 fa28ba3539b79ca6c44ee98d9d5163c2 778 SUPERFAMILY SSF52540 476 739 3.4E-39 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03380 fa28ba3539b79ca6c44ee98d9d5163c2 778 SUPERFAMILY SSF52540 339 443 4.76E-31 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03380 fa28ba3539b79ca6c44ee98d9d5163c2 778 SUPERFAMILY SSF52540 20 189 4.76E-31 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03380 fa28ba3539b79ca6c44ee98d9d5163c2 778 ProSitePatterns PS00211 ABC transporters family signature. 659 673 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS03380 fa28ba3539b79ca6c44ee98d9d5163c2 778 Gene3D G3DSA:1.10.8.280 168 270 4.3E-9 T 09-03-2017 TK78_RS03380 fa28ba3539b79ca6c44ee98d9d5163c2 778 SMART SM00382 492 732 0.0058 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS03380 fa28ba3539b79ca6c44ee98d9d5163c2 778 SMART SM00382 40 430 3.2 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS15870 e5b616c1e421704462abfb3c327073af 333 Gene3D G3DSA:1.10.10.10 256 316 5.6E-9 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS15870 e5b616c1e421704462abfb3c327073af 333 SMART SM00418 251 322 0.0044 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS15870 e5b616c1e421704462abfb3c327073af 333 SUPERFAMILY SSF46785 250 319 1.2E-9 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS09390 da04380c17e2eb1742ee2dfc67f62d81 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 212 224 1.1E-74 T 09-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TK78_RS09390 da04380c17e2eb1742ee2dfc67f62d81 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 120 137 1.1E-74 T 09-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TK78_RS09390 da04380c17e2eb1742ee2dfc67f62d81 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 138 156 1.1E-74 T 09-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TK78_RS09390 da04380c17e2eb1742ee2dfc67f62d81 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 31 44 1.1E-74 T 09-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TK78_RS09390 da04380c17e2eb1742ee2dfc67f62d81 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 93 109 1.1E-74 T 09-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TK78_RS09390 da04380c17e2eb1742ee2dfc67f62d81 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 158 174 1.1E-74 T 09-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TK78_RS09390 da04380c17e2eb1742ee2dfc67f62d81 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 5 24 1.1E-74 T 09-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TK78_RS09390 da04380c17e2eb1742ee2dfc67f62d81 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 262 284 1.1E-74 T 09-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TK78_RS09390 da04380c17e2eb1742ee2dfc67f62d81 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 176 193 1.1E-74 T 09-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TK78_RS09390 da04380c17e2eb1742ee2dfc67f62d81 341 TIGRFAM TIGR02483 PFK_mixed: phosphofructokinase 2 323 2.2E-144 T 09-03-2017 IPR012829 Phosphofructokinase, mixed-substrate PFK group III GO:0006096|GO:0047334 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385 TK78_RS09390 da04380c17e2eb1742ee2dfc67f62d81 341 Hamap MF_01976 Pyrophosphate--fructose 6-phosphate 1-phosphotransferase [pfp]. 1 341 43.198 T 09-03-2017 IPR012829 Phosphofructokinase, mixed-substrate PFK group III GO:0006096|GO:0047334 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385 TK78_RS09390 da04380c17e2eb1742ee2dfc67f62d81 341 Gene3D G3DSA:3.40.50.450 1 213 1.7E-73 T 09-03-2017 TK78_RS09390 da04380c17e2eb1742ee2dfc67f62d81 341 PIRSF PIRSF000532 1 340 2.3E-117 T 09-03-2017 IPR012003 ATP-dependent 6-phosphofructokinase, prokaryotic-type GO:0005524|GO:0006002|GO:0006096|GO:0008443 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385 TK78_RS09390 da04380c17e2eb1742ee2dfc67f62d81 341 ProSitePatterns PS00433 Phosphofructokinase signature. 266 284 - T 09-03-2017 IPR015912 Phosphofructokinase, conserved site GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TK78_RS09390 da04380c17e2eb1742ee2dfc67f62d81 341 Pfam PF00365 Phosphofructokinase 2 297 1.5E-100 T 09-03-2017 IPR000023 Phosphofructokinase domain GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TK78_RS09390 da04380c17e2eb1742ee2dfc67f62d81 341 SUPERFAMILY SSF53784 1 332 1.31E-120 T 09-03-2017 IPR000023 Phosphofructokinase domain GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TK78_RS19360 c28f3f35bdb10179125889de3b52c5e6 207 SUPERFAMILY SSF141571 24 197 1.28E-35 T 09-03-2017 TK78_RS19360 c28f3f35bdb10179125889de3b52c5e6 207 Pfam PF13599 Pentapeptide repeats (9 copies) 38 111 8.8E-10 T 09-03-2017 IPR001646 Pentapeptide repeat TK78_RS19360 c28f3f35bdb10179125889de3b52c5e6 207 Pfam PF00805 Pentapeptide repeats (8 copies) 130 166 1.6E-6 T 09-03-2017 IPR001646 Pentapeptide repeat TK78_RS18680 cf412632565f9fbde64193f1429b11f0 300 SUPERFAMILY SSF52540 5 222 6.27E-51 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18680 cf412632565f9fbde64193f1429b11f0 300 ProSitePatterns PS00211 ABC transporters family signature. 132 146 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS18680 cf412632565f9fbde64193f1429b11f0 300 Pfam PF00005 ABC transporter 25 160 2.6E-25 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS18680 cf412632565f9fbde64193f1429b11f0 300 SMART SM00382 34 209 1.1E-9 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS18680 cf412632565f9fbde64193f1429b11f0 300 Gene3D G3DSA:3.40.50.300 3 221 4.0E-52 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33670 7cf339a955664580b19e491ed8d8e43a 280 ProSitePatterns PS00211 ABC transporters family signature. 155 169 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS33670 7cf339a955664580b19e491ed8d8e43a 280 SMART SM00382 43 231 1.3E-16 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS33670 7cf339a955664580b19e491ed8d8e43a 280 Pfam PF00005 ABC transporter 35 182 4.7E-31 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS33670 7cf339a955664580b19e491ed8d8e43a 280 SUPERFAMILY SSF52540 18 243 2.72E-62 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33670 7cf339a955664580b19e491ed8d8e43a 280 Gene3D G3DSA:3.40.50.300 18 250 7.9E-65 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24135 0b73bce3ece71b9c6dcfb4c10e84f23b 324 SUPERFAMILY SSF53067 120 309 1.85E-33 T 09-03-2017 TK78_RS24135 0b73bce3ece71b9c6dcfb4c10e84f23b 324 SUPERFAMILY SSF53067 7 114 7.13E-13 T 09-03-2017 TK78_RS24135 0b73bce3ece71b9c6dcfb4c10e84f23b 324 Pfam PF01869 BadF/BadG/BcrA/BcrD ATPase family 10 304 4.4E-16 T 09-03-2017 IPR002731 ATPase, BadF/BadG/BcrA/BcrD type Reactome: R-HSA-446210 TK78_RS06685 1e127578f5129c8c71a42f9becd4f7ec 564 Gene3D G3DSA:1.10.510.10 108 280 1.6E-39 T 09-03-2017 TK78_RS06685 1e127578f5129c8c71a42f9becd4f7ec 564 SUPERFAMILY SSF56112 23 281 1.75E-64 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS06685 1e127578f5129c8c71a42f9becd4f7ec 564 Pfam PF00069 Protein kinase domain 26 271 5.3E-37 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS06685 1e127578f5129c8c71a42f9becd4f7ec 564 Gene3D G3DSA:3.30.200.20 21 102 1.5E-12 T 09-03-2017 TK78_RS06685 1e127578f5129c8c71a42f9becd4f7ec 564 SMART SM00220 26 280 1.3E-47 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS06685 1e127578f5129c8c71a42f9becd4f7ec 564 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 32 54 - T 09-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 TK78_RS06685 1e127578f5129c8c71a42f9becd4f7ec 564 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 144 156 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS09670 298b349000cc76d732d389e4fc0513ce 480 Pfam PF00006 ATP synthase alpha/beta family, nucleotide-binding domain 146 359 1.3E-63 T 09-03-2017 IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain GO:0005524 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 TK78_RS09670 298b349000cc76d732d389e4fc0513ce 480 SMART SM00382 158 344 5.9E-5 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS09670 298b349000cc76d732d389e4fc0513ce 480 ProSitePatterns PS00152 ATP synthase alpha and beta subunits signature. 350 359 - T 09-03-2017 IPR020003 ATPase, alpha/beta subunit, nucleotide-binding domain, active site GO:0005524 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 TK78_RS09670 298b349000cc76d732d389e4fc0513ce 480 Pfam PF02874 ATP synthase alpha/beta family, beta-barrel domain 14 88 4.3E-23 T 09-03-2017 IPR004100 ATPase, F1 complex alpha/beta subunit, N-terminal domain GO:0015992|GO:0046034 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 TK78_RS09670 298b349000cc76d732d389e4fc0513ce 480 SUPERFAMILY SSF52540 92 364 3.97E-87 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09670 298b349000cc76d732d389e4fc0513ce 480 Gene3D G3DSA:3.40.50.300 92 361 9.8E-103 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09670 298b349000cc76d732d389e4fc0513ce 480 SUPERFAMILY SSF47917 362 477 1.44E-44 T 09-03-2017 IPR000793 ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal GO:0015991|GO:0016820|GO:0033178 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 TK78_RS09670 298b349000cc76d732d389e4fc0513ce 480 SUPERFAMILY SSF50615 11 89 9.42E-26 T 09-03-2017 IPR004100 ATPase, F1 complex alpha/beta subunit, N-terminal domain GO:0015992|GO:0046034 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 TK78_RS09670 298b349000cc76d732d389e4fc0513ce 480 Gene3D G3DSA:1.10.1140.10 362 477 3.8E-43 T 09-03-2017 IPR024034 ATPase, F1 complex beta subunit/V1 complex, C-terminal KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 TK78_RS09670 298b349000cc76d732d389e4fc0513ce 480 TIGRFAM TIGR01039 atpD: ATP synthase F1, beta subunit 11 477 7.4E-237 T 09-03-2017 IPR005722 ATPase, F1 complex, beta subunit GO:0015986|GO:0046933 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219|Reactome: R-HSA-1268020|Reactome: R-HSA-163210|Reactome: R-HSA-2151201 TK78_RS09670 298b349000cc76d732d389e4fc0513ce 480 Hamap MF_01347 ATP synthase subunit beta [atpB]. 9 477 54.423 T 09-03-2017 IPR005722 ATPase, F1 complex, beta subunit GO:0015986|GO:0046933 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219|Reactome: R-HSA-1268020|Reactome: R-HSA-163210|Reactome: R-HSA-2151201 TK78_RS09670 298b349000cc76d732d389e4fc0513ce 480 Gene3D G3DSA:2.40.10.170 5 89 1.6E-30 T 09-03-2017 TK78_RS09935 5a0e964fede0e1e4bff3edf37d4106f9 428 Pfam PF00877 NlpC/P60 family 295 386 2.9E-19 T 09-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain TK78_RS09935 5a0e964fede0e1e4bff3edf37d4106f9 428 Gene3D G3DSA:3.90.1720.10 278 394 3.5E-37 T 09-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain TK78_RS09935 5a0e964fede0e1e4bff3edf37d4106f9 428 SUPERFAMILY SSF54001 277 394 6.87E-34 T 09-03-2017 TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 197 213 - T 09-03-2017 IPR018201 Beta-ketoacyl synthase, active site TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 SUPERFAMILY SSF51735 1227 1381 1.18E-21 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1708 1723 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 569 866 6.3E-104 T 09-03-2017 IPR020801 Polyketide synthase, acyl transferase domain TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 SMART SM00823 Phosphopantetheine attachment site 1681 1753 1.5E-29 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 SUPERFAMILY SSF53901 436 450 6.2E-105 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 SUPERFAMILY SSF53901 32 404 6.2E-105 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 Gene3D G3DSA:3.40.50.720 1396 1610 1.5E-37 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 SUPERFAMILY SSF47336 1674 1760 1.83E-21 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 291 408 9.5E-45 T 09-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 SMART SM00826 933 1106 1.8E-68 T 09-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 Pfam PF00550 Phosphopantetheine attachment site 1683 1749 1.0E-10 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 Pfam PF08659 KR domain 1397 1576 1.1E-58 T 09-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1397 1577 2.1E-62 T 09-03-2017 TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 Gene3D G3DSA:1.10.1200.10 1678 1754 5.6E-21 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 Pfam PF14765 Polyketide synthase dehydratase 933 1218 3.2E-51 T 09-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 Gene3D G3DSA:3.30.70.250 698 758 2.7E-7 T 09-03-2017 TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 Gene3D G3DSA:3.40.366.10 759 864 6.0E-70 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 Gene3D G3DSA:3.40.366.10 564 693 6.0E-70 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 411 520 1.1E-10 T 09-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 SUPERFAMILY SSF55048 698 759 2.88E-12 T 09-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 Pfam PF08990 Erythronolide synthase docking 3 23 1.3E-7 T 09-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 34 283 6.3E-90 T 09-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 SUPERFAMILY SSF52151 760 857 6.28E-67 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 SUPERFAMILY SSF52151 566 699 6.28E-67 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 Pfam PF00698 Acyl transferase domain 569 853 6.1E-49 T 09-03-2017 IPR014043 Acyl transferase TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 Gene3D G3DSA:3.40.47.10 36 295 6.7E-90 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 SMART SM00825 Beta-ketoacyl synthase 36 461 1.1E-223 T 09-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 SMART SM01294 1682 1749 3.6E-5 T 09-03-2017 TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 Gene3D G3DSA:3.40.47.10 296 463 8.6E-65 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31045 6694b5b0c951af0bf9ba43b6066f9ee4 1838 SUPERFAMILY SSF51735 1396 1651 7.82E-46 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS32585 a6d25903ddf639320ef231ab973e74ad 499 Pfam PF13515 Fusaric acid resistance protein-like 198 323 6.1E-16 T 09-03-2017 TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 Pfam PF00204 DNA gyrase B 261 453 4.8E-55 T 09-03-2017 IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2 GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 Gene3D G3DSA:3.30.230.10 260 453 4.6E-50 T 09-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 PRINTS PR01159 DNA gyrase subunit B signature 231 244 7.6E-37 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 PRINTS PR01159 DNA gyrase subunit B signature 216 231 7.6E-37 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 PRINTS PR01159 DNA gyrase subunit B signature 371 387 7.6E-37 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 PRINTS PR01159 DNA gyrase subunit B signature 675 691 7.6E-37 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 PRINTS PR01159 DNA gyrase subunit B signature 659 671 7.6E-37 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 PRINTS PR01159 DNA gyrase subunit B signature 260 282 7.6E-37 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 PRINTS PR01159 DNA gyrase subunit B signature 437 457 7.6E-37 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 PRINTS PR01159 DNA gyrase subunit B signature 25 35 7.6E-37 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 PRINTS PR01159 DNA gyrase subunit B signature 533 542 7.6E-37 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 50 160 2.3E-21 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 Gene3D G3DSA:3.30.565.10 25 245 5.7E-82 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 Pfam PF01751 Toprim domain 482 589 1.7E-16 T 09-03-2017 IPR006171 Toprim domain TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 SMART SM00387 50 210 9.0E-24 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 Pfam PF00986 DNA gyrase B subunit, carboxyl terminus 636 694 1.9E-24 T 09-03-2017 IPR002288 DNA gyrase B subunit, C-terminal GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 SUPERFAMILY SSF55874 25 244 5.37E-59 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 SUPERFAMILY SSF56719 457 698 2.09E-76 T 09-03-2017 IPR013760 DNA topoisomerase, type IIA-like domain GO:0003918|GO:0005524 Reactome: R-HSA-4615885 TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 PRINTS PR00418 DNA topoisomerase II family signature 587 599 9.4E-61 T 09-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 PRINTS PR00418 DNA topoisomerase II family signature 89 102 9.4E-61 T 09-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 PRINTS PR00418 DNA topoisomerase II family signature 638 654 9.4E-61 T 09-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 PRINTS PR00418 DNA topoisomerase II family signature 483 497 9.4E-61 T 09-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 PRINTS PR00418 DNA topoisomerase II family signature 132 146 9.4E-61 T 09-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 PRINTS PR00418 DNA topoisomerase II family signature 327 340 9.4E-61 T 09-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 PRINTS PR00418 DNA topoisomerase II family signature 549 565 9.4E-61 T 09-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 PRINTS PR00418 DNA topoisomerase II family signature 567 584 9.4E-61 T 09-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 PRINTS PR00418 DNA topoisomerase II family signature 54 69 9.4E-61 T 09-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 SMART SM00433 54 699 1.2E-284 T 09-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 Gene3D G3DSA:3.40.50.670 467 687 2.0E-75 T 09-03-2017 IPR013759 DNA topoisomerase, type IIA, central domain GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 ProSitePatterns PS00177 DNA topoisomerase II signature. 485 493 - T 09-03-2017 IPR018522 DNA topoisomerase, type IIA, conserved site GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS07250 ff9adf2d091a1c0ae12ee2d59049d349 708 SUPERFAMILY SSF54211 261 453 8.16E-39 T 09-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold TK78_RS04775 7e8b31411eba9398c915d5f67f73c925 259 TIGRFAM TIGR00195 exoDNase_III: exodeoxyribonuclease III 1 256 2.9E-56 T 09-03-2017 TK78_RS04775 7e8b31411eba9398c915d5f67f73c925 259 Gene3D G3DSA:3.60.10.10 1 257 4.2E-75 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS04775 7e8b31411eba9398c915d5f67f73c925 259 TIGRFAM TIGR00633 xth: exodeoxyribonuclease III (xth) 1 257 4.1E-76 T 09-03-2017 IPR004808 AP endonuclease 1 GO:0004518|GO:0006281 TK78_RS04775 7e8b31411eba9398c915d5f67f73c925 259 SUPERFAMILY SSF56219 1 258 4.32E-66 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS04775 7e8b31411eba9398c915d5f67f73c925 259 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 4 250 8.3E-19 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS20020 a91385f10e6d4e0f30d34e1d494d5707 556 Gene3D G3DSA:3.30.950.10 139 278 3.0E-29 T 09-03-2017 IPR014776 Tetrapyrrole methylase, subdomain 2 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS20020 a91385f10e6d4e0f30d34e1d494d5707 556 Gene3D G3DSA:3.40.50.10090 409 528 3.3E-34 T 09-03-2017 TK78_RS20020 a91385f10e6d4e0f30d34e1d494d5707 556 Gene3D G3DSA:3.40.50.10090 279 401 4.1E-41 T 09-03-2017 TK78_RS20020 a91385f10e6d4e0f30d34e1d494d5707 556 Pfam PF02602 Uroporphyrinogen-III synthase HemD 288 518 3.9E-63 T 09-03-2017 IPR003754 Tetrapyrrole biosynthesis, uroporphyrinogen III synthase GO:0004852|GO:0033014 KEGG: 00860+4.2.1.75|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS20020 a91385f10e6d4e0f30d34e1d494d5707 556 ProSitePatterns PS00839 Uroporphyrin-III C-methyltransferase signature 1. 23 37 - T 09-03-2017 IPR003043 Uroporphiryn-III C-methyltransferase, conserved site GO:0008168|GO:0055114 KEGG: 00270+2.1.1.10|KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5441|MetaCyc: PWY-702|MetaCyc: PWY-7377 TK78_RS20020 a91385f10e6d4e0f30d34e1d494d5707 556 Gene3D G3DSA:3.40.1010.10 17 136 7.0E-30 T 09-03-2017 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS20020 a91385f10e6d4e0f30d34e1d494d5707 556 SUPERFAMILY SSF53790 17 277 1.83E-42 T 09-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS20020 a91385f10e6d4e0f30d34e1d494d5707 556 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 20 229 3.7E-32 T 09-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS20020 a91385f10e6d4e0f30d34e1d494d5707 556 SUPERFAMILY SSF69618 274 523 1.06E-65 T 09-03-2017 IPR003754 Tetrapyrrole biosynthesis, uroporphyrinogen III synthase GO:0004852|GO:0033014 KEGG: 00860+4.2.1.75|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS21540 3bc841f409c567648cc74b0beb72e3d4 550 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 16 39 - T 09-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 TK78_RS21540 3bc841f409c567648cc74b0beb72e3d4 550 Gene3D G3DSA:1.10.510.10 83 273 2.8E-45 T 09-03-2017 TK78_RS21540 3bc841f409c567648cc74b0beb72e3d4 550 Pfam PF00069 Protein kinase domain 10 270 3.6E-41 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS21540 3bc841f409c567648cc74b0beb72e3d4 550 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 136 148 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS21540 3bc841f409c567648cc74b0beb72e3d4 550 SUPERFAMILY SSF56112 7 347 8.36E-75 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS21540 3bc841f409c567648cc74b0beb72e3d4 550 SUPERFAMILY SSF48452 402 520 1.8E-5 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS21540 3bc841f409c567648cc74b0beb72e3d4 550 Gene3D G3DSA:3.30.200.20 3 82 2.0E-23 T 09-03-2017 TK78_RS21540 3bc841f409c567648cc74b0beb72e3d4 550 Gene3D G3DSA:1.25.40.10 374 525 5.0E-7 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS21540 3bc841f409c567648cc74b0beb72e3d4 550 SMART SM00220 10 279 4.0E-57 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS22240 dca112b757be1bbeddd28635b3c8d3d7 414 Pfam PF00069 Protein kinase domain 9 262 1.1E-45 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS22240 dca112b757be1bbeddd28635b3c8d3d7 414 SUPERFAMILY SSF56112 6 264 5.65E-66 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS22240 dca112b757be1bbeddd28635b3c8d3d7 414 Gene3D G3DSA:1.10.510.10 72 262 1.8E-47 T 09-03-2017 TK78_RS22240 dca112b757be1bbeddd28635b3c8d3d7 414 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 126 138 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS22240 dca112b757be1bbeddd28635b3c8d3d7 414 Gene3D G3DSA:3.30.200.20 4 71 4.1E-16 T 09-03-2017 TK78_RS22240 dca112b757be1bbeddd28635b3c8d3d7 414 SMART SM00220 9 273 1.2E-60 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS05785 d2464859bc62991422a365f6e134987f 292 Gene3D G3DSA:1.10.260.40 34 91 3.0E-10 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS05785 d2464859bc62991422a365f6e134987f 292 SUPERFAMILY SSF47413 32 85 1.9E-10 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS05785 d2464859bc62991422a365f6e134987f 292 SMART SM00530 38 93 2.8E-7 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS05785 d2464859bc62991422a365f6e134987f 292 Pfam PF13560 Helix-turn-helix domain 35 88 2.9E-11 T 09-03-2017 TK78_RS07990 b46b1dbf5c7155f0235d58466f229b90 387 Gene3D G3DSA:3.40.190.10 43 163 6.8E-37 T 09-03-2017 TK78_RS07990 b46b1dbf5c7155f0235d58466f229b90 387 Gene3D G3DSA:3.40.190.10 303 339 6.8E-37 T 09-03-2017 TK78_RS07990 b46b1dbf5c7155f0235d58466f229b90 387 Gene3D G3DSA:3.40.190.10 165 302 3.6E-13 T 09-03-2017 TK78_RS07990 b46b1dbf5c7155f0235d58466f229b90 387 Pfam PF13416 Bacterial extracellular solute-binding protein 69 337 1.8E-26 T 09-03-2017 TK78_RS07990 b46b1dbf5c7155f0235d58466f229b90 387 SUPERFAMILY SSF53850 44 385 2.43E-59 T 09-03-2017 TK78_RS07990 b46b1dbf5c7155f0235d58466f229b90 387 PRINTS PR00909 Bacterial periplasmic spermidine/putrescine-binding protein signature 280 299 5.7E-16 T 09-03-2017 IPR001188 Bacterial periplasmic spermidine/putrescine-binding protein GO:0015846|GO:0019808|GO:0042597 TK78_RS07990 b46b1dbf5c7155f0235d58466f229b90 387 PRINTS PR00909 Bacterial periplasmic spermidine/putrescine-binding protein signature 106 120 5.7E-16 T 09-03-2017 IPR001188 Bacterial periplasmic spermidine/putrescine-binding protein GO:0015846|GO:0019808|GO:0042597 TK78_RS07990 b46b1dbf5c7155f0235d58466f229b90 387 PRINTS PR00909 Bacterial periplasmic spermidine/putrescine-binding protein signature 179 193 5.7E-16 T 09-03-2017 IPR001188 Bacterial periplasmic spermidine/putrescine-binding protein GO:0015846|GO:0019808|GO:0042597 TK78_RS07990 b46b1dbf5c7155f0235d58466f229b90 387 PRINTS PR00909 Bacterial periplasmic spermidine/putrescine-binding protein signature 122 135 5.7E-16 T 09-03-2017 IPR001188 Bacterial periplasmic spermidine/putrescine-binding protein GO:0015846|GO:0019808|GO:0042597 TK78_RS07990 b46b1dbf5c7155f0235d58466f229b90 387 PRINTS PR00909 Bacterial periplasmic spermidine/putrescine-binding protein signature 154 170 5.7E-16 T 09-03-2017 IPR001188 Bacterial periplasmic spermidine/putrescine-binding protein GO:0015846|GO:0019808|GO:0042597 TK78_RS07990 b46b1dbf5c7155f0235d58466f229b90 387 PRINTS PR00909 Bacterial periplasmic spermidine/putrescine-binding protein signature 236 255 5.7E-16 T 09-03-2017 IPR001188 Bacterial periplasmic spermidine/putrescine-binding protein GO:0015846|GO:0019808|GO:0042597 TK78_RS31300 13fe90fde07ab8bb32c573d8c378c4cc 290 TIGRFAM TIGR00753 undec_PP_bacA: undecaprenyl-diphosphatase UppP 7 269 3.5E-76 T 09-03-2017 IPR003824 Undecaprenyl-diphosphatase UppP GO:0016020|GO:0016311|GO:0050380 KEGG: 00550+3.6.1.27|MetaCyc: PWY-5785 TK78_RS31300 13fe90fde07ab8bb32c573d8c378c4cc 290 Pfam PF02673 Bacitracin resistance protein BacA 7 271 3.8E-76 T 09-03-2017 IPR003824 Undecaprenyl-diphosphatase UppP GO:0016020|GO:0016311|GO:0050380 KEGG: 00550+3.6.1.27|MetaCyc: PWY-5785 TK78_RS31300 13fe90fde07ab8bb32c573d8c378c4cc 290 Hamap MF_01006 Undecaprenyl-diphosphatase [uppP]. 1 276 17.775 T 09-03-2017 IPR003824 Undecaprenyl-diphosphatase UppP GO:0016020|GO:0016311|GO:0050380 KEGG: 00550+3.6.1.27|MetaCyc: PWY-5785 TK78_RS06280 e31d15d85107d5f9feddfb8a0c7325b6 327 Gene3D G3DSA:3.40.50.720 21 225 1.5E-64 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS06280 e31d15d85107d5f9feddfb8a0c7325b6 327 Hamap MF_00956 GDP-L-fucose synthase [fcl]. 20 321 49.192 T 09-03-2017 IPR028614 GDP-L-fucose synthase/GDP-L-colitose synthase GO:0009226|GO:0016491 KEGG: 00010+1.1.1.27|KEGG: 00051+1.1.1.271|KEGG: 00270+1.1.1.27|KEGG: 00520+1.1.1.271|KEGG: 00620+1.1.1.27|KEGG: 00640+1.1.1.27|MetaCyc: PWY-5481|MetaCyc: PWY-66|MetaCyc: PWY-6901|Reactome: R-HSA-6787639 TK78_RS06280 e31d15d85107d5f9feddfb8a0c7325b6 327 SUPERFAMILY SSF51735 19 321 3.31E-76 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS06280 e31d15d85107d5f9feddfb8a0c7325b6 327 Gene3D G3DSA:3.90.25.10 300 320 5.2E-9 T 09-03-2017 TK78_RS06280 e31d15d85107d5f9feddfb8a0c7325b6 327 Gene3D G3DSA:3.90.25.10 226 247 5.2E-9 T 09-03-2017 TK78_RS06280 e31d15d85107d5f9feddfb8a0c7325b6 327 Pfam PF01370 NAD dependent epimerase/dehydratase family 23 253 1.5E-72 T 09-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 TK78_RS18245 78e34d5480bf2264c92a83460da7c7e4 749 SUPERFAMILY SSF56042 583 747 1.38E-36 T 09-03-2017 IPR010918 AIR synthase-related protein, C-terminal domain TK78_RS18245 78e34d5480bf2264c92a83460da7c7e4 749 SUPERFAMILY SSF55326 410 578 1.2E-54 T 09-03-2017 TK78_RS18245 78e34d5480bf2264c92a83460da7c7e4 749 Gene3D G3DSA:3.30.1330.10 427 576 7.8E-54 T 09-03-2017 IPR016188 PurM-like, N-terminal domain TK78_RS18245 78e34d5480bf2264c92a83460da7c7e4 749 Gene3D G3DSA:3.30.1330.10 56 203 8.0E-53 T 09-03-2017 IPR016188 PurM-like, N-terminal domain TK78_RS18245 78e34d5480bf2264c92a83460da7c7e4 749 Pfam PF00586 AIR synthase related protein, N-terminal domain 96 198 3.1E-22 T 09-03-2017 IPR016188 PurM-like, N-terminal domain TK78_RS18245 78e34d5480bf2264c92a83460da7c7e4 749 Pfam PF00586 AIR synthase related protein, N-terminal domain 454 572 1.2E-22 T 09-03-2017 IPR016188 PurM-like, N-terminal domain TK78_RS18245 78e34d5480bf2264c92a83460da7c7e4 749 Hamap MF_00420 Phosphoribosylformylglycinamidine synthase subunit PurL [purL]. 1 749 306.566 T 09-03-2017 IPR010074 Phosphoribosylformylglycinamidine subunit PurL GO:0004642|GO:0005737|GO:0006189 KEGG: 00230+6.3.5.3|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277 TK78_RS18245 78e34d5480bf2264c92a83460da7c7e4 749 TIGRFAM TIGR01736 FGAM_synth_II: phosphoribosylformylglycinamidine synthase II 24 746 8.8E-260 T 09-03-2017 IPR010074 Phosphoribosylformylglycinamidine subunit PurL GO:0004642|GO:0005737|GO:0006189 KEGG: 00230+6.3.5.3|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277 TK78_RS18245 78e34d5480bf2264c92a83460da7c7e4 749 Gene3D G3DSA:3.90.650.10 262 364 6.6E-4 T 09-03-2017 IPR010918 AIR synthase-related protein, C-terminal domain TK78_RS18245 78e34d5480bf2264c92a83460da7c7e4 749 PIRSF PIRSF001587 7 749 1.1E-287 T 09-03-2017 IPR010074 Phosphoribosylformylglycinamidine subunit PurL GO:0004642|GO:0005737|GO:0006189 KEGG: 00230+6.3.5.3|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277 TK78_RS18245 78e34d5480bf2264c92a83460da7c7e4 749 SUPERFAMILY SSF55326 20 204 1.5E-49 T 09-03-2017 TK78_RS18245 78e34d5480bf2264c92a83460da7c7e4 749 SUPERFAMILY SSF56042 209 439 1.79E-51 T 09-03-2017 IPR010918 AIR synthase-related protein, C-terminal domain TK78_RS18245 78e34d5480bf2264c92a83460da7c7e4 749 Pfam PF02769 AIR synthase related protein, C-terminal domain 585 722 1.3E-18 T 09-03-2017 IPR010918 AIR synthase-related protein, C-terminal domain TK78_RS18245 78e34d5480bf2264c92a83460da7c7e4 749 Pfam PF02769 AIR synthase related protein, C-terminal domain 211 366 1.6E-32 T 09-03-2017 IPR010918 AIR synthase-related protein, C-terminal domain TK78_RS30100 9118c2e59e729a4b288ce5e2a9bdcfc8 197 Hamap MF_01615 Pyridoxal 5'-phosphate synthase subunit PdxT [pdxT]. 7 192 36.938 T 09-03-2017 IPR002161 Pyridoxal 5'-phosphate synthase subunit PdxT/SNO GO:0004359|GO:0042819|GO:0042823 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|KEGG: 00750+4.3.3.6|MetaCyc: PWY-6466 TK78_RS30100 9118c2e59e729a4b288ce5e2a9bdcfc8 197 ProSitePatterns PS01236 PdxT/SNO family family signature. 44 54 - T 09-03-2017 IPR021196 PdxT/SNO family, conserved site KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|KEGG: 00750+4.3.3.6|MetaCyc: PWY-6466 TK78_RS30100 9118c2e59e729a4b288ce5e2a9bdcfc8 197 Gene3D G3DSA:3.40.50.880 4 195 8.1E-78 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS30100 9118c2e59e729a4b288ce5e2a9bdcfc8 197 PIRSF PIRSF005639 1 197 2.3E-73 T 09-03-2017 IPR002161 Pyridoxal 5'-phosphate synthase subunit PdxT/SNO GO:0004359|GO:0042819|GO:0042823 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|KEGG: 00750+4.3.3.6|MetaCyc: PWY-6466 TK78_RS30100 9118c2e59e729a4b288ce5e2a9bdcfc8 197 SUPERFAMILY SSF52317 6 193 1.15E-52 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS30100 9118c2e59e729a4b288ce5e2a9bdcfc8 197 Pfam PF01174 SNO glutamine amidotransferase family 9 193 5.9E-59 T 09-03-2017 IPR002161 Pyridoxal 5'-phosphate synthase subunit PdxT/SNO GO:0004359|GO:0042819|GO:0042823 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|KEGG: 00750+4.3.3.6|MetaCyc: PWY-6466 TK78_RS30100 9118c2e59e729a4b288ce5e2a9bdcfc8 197 TIGRFAM TIGR03800 PLP_synth_Pdx2: pyridoxal 5'-phosphate synthase, glutaminase subunit Pdx2 7 191 1.4E-81 T 09-03-2017 IPR002161 Pyridoxal 5'-phosphate synthase subunit PdxT/SNO GO:0004359|GO:0042819|GO:0042823 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|KEGG: 00750+4.3.3.6|MetaCyc: PWY-6466 TK78_RS34515 ff5405634e51966156c6f352e5e5a99f 205 SUPERFAMILY SSF51182 19 178 7.89E-15 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS34515 ff5405634e51966156c6f352e5e5a99f 205 Gene3D G3DSA:1.10.260.40 13 83 2.2E-20 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS34515 ff5405634e51966156c6f352e5e5a99f 205 SUPERFAMILY SSF47413 11 75 7.32E-18 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS34515 ff5405634e51966156c6f352e5e5a99f 205 SMART SM00530 15 70 1.2E-18 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS34515 ff5405634e51966156c6f352e5e5a99f 205 Gene3D G3DSA:2.60.120.10 84 175 9.3E-14 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS34515 ff5405634e51966156c6f352e5e5a99f 205 Pfam PF07883 Cupin domain 118 174 2.0E-8 T 09-03-2017 IPR013096 Cupin 2, conserved barrel TK78_RS34515 ff5405634e51966156c6f352e5e5a99f 205 Pfam PF01381 Helix-turn-helix 16 70 1.7E-16 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS15365 1c5050863522cf7d5c1c42bdd9f3c541 281 TIGRFAM TIGR01490 HAD-SF-IB-hyp1: HAD hydrolase, family IB 14 214 1.4E-60 T 09-03-2017 IPR006385 HAD-superfamily hydrolase, subfamily IB, PSPase-like, bacterial TK78_RS15365 1c5050863522cf7d5c1c42bdd9f3c541 281 Pfam PF12710 haloacid dehalogenase-like hydrolase 15 201 6.1E-31 T 09-03-2017 TK78_RS15365 1c5050863522cf7d5c1c42bdd9f3c541 281 Gene3D G3DSA:3.40.50.1000 86 236 2.9E-47 T 09-03-2017 IPR023214 HAD-like domain TK78_RS15365 1c5050863522cf7d5c1c42bdd9f3c541 281 TIGRFAM TIGR01488 HAD-SF-IB: HAD phosphoserine phosphatase-like hydrolase, family IB 14 203 4.7E-21 T 09-03-2017 IPR006383 HAD-superfamily hydrolase, subfamily IB, PSPase-like GO:0008152|GO:0016791 TK78_RS15365 1c5050863522cf7d5c1c42bdd9f3c541 281 SUPERFAMILY SSF56784 12 222 1.07E-29 T 09-03-2017 IPR023214 HAD-like domain TK78_RS02210 7f8478847be7e57da6bdab3846cdd3c9 298 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 1.5E-11 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS02210 7f8478847be7e57da6bdab3846cdd3c9 298 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 1.5E-11 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS02210 7f8478847be7e57da6bdab3846cdd3c9 298 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 1.5E-11 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS02210 7f8478847be7e57da6bdab3846cdd3c9 298 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 3 62 7.5E-24 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS02210 7f8478847be7e57da6bdab3846cdd3c9 298 SUPERFAMILY SSF53850 90 293 4.15E-42 T 09-03-2017 TK78_RS02210 7f8478847be7e57da6bdab3846cdd3c9 298 Pfam PF03466 LysR substrate binding domain 89 293 1.3E-44 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS02210 7f8478847be7e57da6bdab3846cdd3c9 298 Gene3D G3DSA:1.10.10.10 1 84 4.4E-31 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS02210 7f8478847be7e57da6bdab3846cdd3c9 298 Gene3D G3DSA:3.40.190.10 178 267 4.0E-23 T 09-03-2017 TK78_RS02210 7f8478847be7e57da6bdab3846cdd3c9 298 Gene3D G3DSA:3.40.190.10 90 177 4.3E-21 T 09-03-2017 TK78_RS02210 7f8478847be7e57da6bdab3846cdd3c9 298 SUPERFAMILY SSF46785 1 110 1.25E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS34295 5d6e804139630133d4452ffb5f137760 253 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 24 38 2.0E-9 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS34295 5d6e804139630133d4452ffb5f137760 253 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 38 56 2.0E-9 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS34295 5d6e804139630133d4452ffb5f137760 253 SUPERFAMILY SSF100950 77 234 8.58E-25 T 09-03-2017 TK78_RS34295 5d6e804139630133d4452ffb5f137760 253 SMART SM01134 73 234 4.5E-65 T 09-03-2017 TK78_RS34295 5d6e804139630133d4452ffb5f137760 253 Pfam PF08220 DeoR-like helix-turn-helix domain 6 57 1.4E-15 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS34295 5d6e804139630133d4452ffb5f137760 253 Pfam PF00455 DeoR C terminal sensor domain 76 233 9.5E-50 T 09-03-2017 IPR014036 DeoR C-terminal sensor domain TK78_RS34295 5d6e804139630133d4452ffb5f137760 253 Gene3D G3DSA:3.40.50.1360 77 215 2.8E-8 T 09-03-2017 TK78_RS34295 5d6e804139630133d4452ffb5f137760 253 SUPERFAMILY SSF46785 5 60 2.7E-13 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS34295 5d6e804139630133d4452ffb5f137760 253 SMART SM00420 6 58 6.9E-14 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS34295 5d6e804139630133d4452ffb5f137760 253 Gene3D G3DSA:1.10.10.10 5 55 6.5E-10 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS30950 31724d25f35126b976ec14b5c100f80b 304 Gene3D G3DSA:3.40.190.10 91 183 3.4E-17 T 09-03-2017 TK78_RS30950 31724d25f35126b976ec14b5c100f80b 304 SUPERFAMILY SSF46785 1 111 1.04E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS30950 31724d25f35126b976ec14b5c100f80b 304 Pfam PF03466 LysR substrate binding domain 88 292 6.8E-39 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS30950 31724d25f35126b976ec14b5c100f80b 304 Gene3D G3DSA:3.40.190.10 184 266 7.7E-23 T 09-03-2017 TK78_RS30950 31724d25f35126b976ec14b5c100f80b 304 Gene3D G3DSA:1.10.10.10 1 88 1.8E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS30950 31724d25f35126b976ec14b5c100f80b 304 SUPERFAMILY SSF53850 89 297 1.23E-34 T 09-03-2017 TK78_RS30950 31724d25f35126b976ec14b5c100f80b 304 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 4 63 1.0E-20 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS31060 63b5f1b84c7561fc8938b039fa492ca4 507 Pfam PF08031 Berberine and berberine like 444 497 9.2E-15 T 09-03-2017 IPR012951 Berberine/berberine-like GO:0016491|GO:0050660|GO:0055114 TK78_RS31060 63b5f1b84c7561fc8938b039fa492ca4 507 ProSitePatterns PS00862 Oxygen oxidoreductases covalent FAD-binding site. 27 60 - T 09-03-2017 IPR006093 Oxygen oxidoreductase covalent FAD-binding site GO:0016491|GO:0055114 TK78_RS31060 63b5f1b84c7561fc8938b039fa492ca4 507 SUPERFAMILY SSF56176 11 200 1.26E-35 T 09-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 TK78_RS31060 63b5f1b84c7561fc8938b039fa492ca4 507 Gene3D G3DSA:3.30.43.10 36 84 7.0E-7 T 09-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 TK78_RS31060 63b5f1b84c7561fc8938b039fa492ca4 507 Pfam PF01565 FAD binding domain 33 161 8.6E-20 T 09-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 TK78_RS31060 63b5f1b84c7561fc8938b039fa492ca4 507 Gene3D G3DSA:3.30.465.10 85 199 1.6E-9 T 09-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 TK78_RS19210 2ef18176f91c15c98af7a4cff7395f91 280 SUPERFAMILY SSF56534 2 262 4.32E-68 T 09-03-2017 IPR019774 Aromatic amino acid hydroxylase, C-terminal GO:0016714|GO:0055114 TK78_RS19210 2ef18176f91c15c98af7a4cff7395f91 280 Gene3D G3DSA:1.10.800.10 2 263 3.5E-74 T 09-03-2017 IPR001273 Aromatic amino acid hydroxylase GO:0004497|GO:0005506|GO:0009072|GO:0055114 TK78_RS19210 2ef18176f91c15c98af7a4cff7395f91 280 PRINTS PR00372 Biopterin-dependent aromatic amino acid hydroxylase signature 6 25 1.0E-10 T 09-03-2017 IPR019774 Aromatic amino acid hydroxylase, C-terminal GO:0016714|GO:0055114 TK78_RS19210 2ef18176f91c15c98af7a4cff7395f91 280 PRINTS PR00372 Biopterin-dependent aromatic amino acid hydroxylase signature 93 115 1.0E-10 T 09-03-2017 IPR019774 Aromatic amino acid hydroxylase, C-terminal GO:0016714|GO:0055114 TK78_RS19210 2ef18176f91c15c98af7a4cff7395f91 280 PRINTS PR00372 Biopterin-dependent aromatic amino acid hydroxylase signature 198 216 1.0E-10 T 09-03-2017 IPR019774 Aromatic amino acid hydroxylase, C-terminal GO:0016714|GO:0055114 TK78_RS19210 2ef18176f91c15c98af7a4cff7395f91 280 Pfam PF00351 Biopterin-dependent aromatic amino acid hydroxylase 2 256 5.0E-54 T 09-03-2017 IPR019774 Aromatic amino acid hydroxylase, C-terminal GO:0016714|GO:0055114 TK78_RS01905 ba08a6e60c897f1705303ad490eb00d2 321 SUPERFAMILY SSF51182 36 304 1.94E-67 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS01905 ba08a6e60c897f1705303ad490eb00d2 321 Gene3D G3DSA:2.60.120.10 25 265 1.9E-59 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS01905 ba08a6e60c897f1705303ad490eb00d2 321 Pfam PF05726 Pirin C-terminal cupin domain 193 292 1.1E-18 T 09-03-2017 IPR008778 Pirin, C-terminal domain TK78_RS01905 ba08a6e60c897f1705303ad490eb00d2 321 PIRSF PIRSF006232 20 302 3.0E-80 T 09-03-2017 IPR012093 Pirin TK78_RS01905 ba08a6e60c897f1705303ad490eb00d2 321 Pfam PF02678 Pirin 41 141 5.0E-24 T 09-03-2017 IPR003829 Pirin, N-terminal domain TK78_RS32495 74dd7216139705a93897bb259c8eec75 489 TIGRFAM TIGR00908 2A0305: ethanolamine permease 28 475 2.1E-146 T 09-03-2017 IPR004757 Ethanolamine permease TK78_RS32495 74dd7216139705a93897bb259c8eec75 489 PIRSF PIRSF006060 25 485 6.0E-64 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS32495 74dd7216139705a93897bb259c8eec75 489 Pfam PF13520 Amino acid permease 44 453 1.3E-39 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS29785 f0a3a44b1c6a41e169633335c0f50be2 1172 SUPERFAMILY SSF51197 870 1157 2.93E-65 T 09-03-2017 TK78_RS29785 f0a3a44b1c6a41e169633335c0f50be2 1172 Pfam PF00550 Phosphopantetheine attachment site 733 792 3.8E-11 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29785 f0a3a44b1c6a41e169633335c0f50be2 1172 Pfam PF02668 Taurine catabolism dioxygenase TauD, TfdA family 869 1154 3.2E-40 T 09-03-2017 IPR003819 TauD/TfdA-like domain GO:0016491|GO:0055114 Reactome: R-HSA-71262 TK78_RS29785 f0a3a44b1c6a41e169633335c0f50be2 1172 ProSitePatterns PS00455 Putative AMP-binding domain signature. 363 374 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS29785 f0a3a44b1c6a41e169633335c0f50be2 1172 Gene3D G3DSA:2.30.38.10 532 611 8.3E-25 T 09-03-2017 TK78_RS29785 f0a3a44b1c6a41e169633335c0f50be2 1172 Gene3D G3DSA:3.40.50.980 373 517 2.4E-44 T 09-03-2017 TK78_RS29785 f0a3a44b1c6a41e169633335c0f50be2 1172 Gene3D G3DSA:3.60.130.10 1038 1159 1.1E-54 T 09-03-2017 TK78_RS29785 f0a3a44b1c6a41e169633335c0f50be2 1172 Gene3D G3DSA:3.60.130.10 870 1006 1.1E-54 T 09-03-2017 TK78_RS29785 f0a3a44b1c6a41e169633335c0f50be2 1172 Gene3D G3DSA:3.30.300.30 617 733 1.7E-34 T 09-03-2017 TK78_RS29785 f0a3a44b1c6a41e169633335c0f50be2 1172 SUPERFAMILY SSF47336 725 792 2.88E-13 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29785 f0a3a44b1c6a41e169633335c0f50be2 1172 Pfam PF00501 AMP-binding enzyme 220 621 3.8E-91 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS29785 f0a3a44b1c6a41e169633335c0f50be2 1172 Gene3D G3DSA:1.10.1200.10 734 796 2.3E-19 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29785 f0a3a44b1c6a41e169633335c0f50be2 1172 Gene3D G3DSA:3.40.50.980 213 372 7.9E-46 T 09-03-2017 TK78_RS29785 f0a3a44b1c6a41e169633335c0f50be2 1172 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 241 645 6.8E-119 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS29785 f0a3a44b1c6a41e169633335c0f50be2 1172 Pfam PF13193 AMP-binding enzyme C-terminal domain 629 701 3.3E-10 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS29785 f0a3a44b1c6a41e169633335c0f50be2 1172 SUPERFAMILY SSF56801 179 744 6.15E-150 T 09-03-2017 TK78_RS29785 f0a3a44b1c6a41e169633335c0f50be2 1172 SUPERFAMILY SSF52777 5 184 9.12E-9 T 09-03-2017 TK78_RS03955 15eccf77271d8c637875703ab1ed31bc 507 ProSitePatterns PS00211 ABC transporters family signature. 405 419 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS03955 15eccf77271d8c637875703ab1ed31bc 507 Gene3D G3DSA:3.40.50.300 264 495 1.5E-47 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03955 15eccf77271d8c637875703ab1ed31bc 507 SUPERFAMILY SSF52540 6 230 2.66E-55 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03955 15eccf77271d8c637875703ab1ed31bc 507 SMART SM00382 287 481 2.9E-5 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS03955 15eccf77271d8c637875703ab1ed31bc 507 SMART SM00382 32 222 1.3E-9 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS03955 15eccf77271d8c637875703ab1ed31bc 507 SUPERFAMILY SSF52540 259 493 6.26E-44 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03955 15eccf77271d8c637875703ab1ed31bc 507 Gene3D G3DSA:3.40.50.300 4 230 7.1E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03955 15eccf77271d8c637875703ab1ed31bc 507 Pfam PF00005 ABC transporter 23 174 1.1E-26 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS03955 15eccf77271d8c637875703ab1ed31bc 507 Pfam PF00005 ABC transporter 280 432 6.1E-20 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS09710 4669e6a7cffd4b814bafd256bc35b67b 474 Pfam PF00953 Glycosyl transferase family 4 96 255 3.1E-35 T 09-03-2017 IPR000715 Glycosyl transferase, family 4 GO:0008963|GO:0016021 KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471|Reactome: R-HSA-446193|Reactome: R-HSA-4549356 TK78_RS03710 68020e54545b052532d70c9864caa91a 389 SUPERFAMILY SSF52540 66 292 2.97E-77 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03710 68020e54545b052532d70c9864caa91a 389 TIGRFAM TIGR01186 proV: glycine betaine/L-proline transport ATP binding subunit 59 351 2.2E-108 T 09-03-2017 IPR005892 Glycine betaine transport ATP-binding subunit GO:0005524|GO:0016020|GO:0031460 TK78_RS03710 68020e54545b052532d70c9864caa91a 389 SUPERFAMILY SSF54631 315 361 5.9E-5 T 09-03-2017 TK78_RS03710 68020e54545b052532d70c9864caa91a 389 Gene3D G3DSA:3.10.580.10 315 361 4.9E-4 T 09-03-2017 TK78_RS03710 68020e54545b052532d70c9864caa91a 389 Pfam PF00005 ABC transporter 68 215 9.5E-34 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS03710 68020e54545b052532d70c9864caa91a 389 SMART SM00382 76 273 2.6E-18 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS03710 68020e54545b052532d70c9864caa91a 389 ProSitePatterns PS00211 ABC transporters family signature. 188 202 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS03710 68020e54545b052532d70c9864caa91a 389 Gene3D G3DSA:3.40.50.300 27 288 1.1E-80 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18855 4cd3e7809de70d9301b041b6f94734c8 95 Gene3D G3DSA:2.60.40.10 19 83 2.1E-5 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS18855 4cd3e7809de70d9301b041b6f94734c8 95 Pfam PF07210 Protein of unknown function (DUF1416) 2 95 1.6E-35 T 09-03-2017 IPR010814 Protein of unknown function DUF1416 TK78_RS18855 4cd3e7809de70d9301b041b6f94734c8 95 SUPERFAMILY SSF49478 21 78 3.84E-5 T 09-03-2017 TK78_RS14000 359f840203a4eb1e385561003ba72b16 523 Pfam PF00501 AMP-binding enzyme 25 424 2.4E-72 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS14000 359f840203a4eb1e385561003ba72b16 523 Gene3D G3DSA:3.40.50.980 185 336 1.7E-26 T 09-03-2017 TK78_RS14000 359f840203a4eb1e385561003ba72b16 523 ProSitePatterns PS00455 Putative AMP-binding domain signature. 177 188 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS14000 359f840203a4eb1e385561003ba72b16 523 Gene3D G3DSA:3.30.300.30 419 520 3.6E-25 T 09-03-2017 TK78_RS14000 359f840203a4eb1e385561003ba72b16 523 Gene3D G3DSA:3.40.50.980 18 184 2.4E-27 T 09-03-2017 TK78_RS14000 359f840203a4eb1e385561003ba72b16 523 SUPERFAMILY SSF56801 18 521 3.4E-119 T 09-03-2017 TK78_RS14000 359f840203a4eb1e385561003ba72b16 523 Pfam PF13193 AMP-binding enzyme C-terminal domain 433 507 2.6E-13 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS14000 359f840203a4eb1e385561003ba72b16 523 Gene3D G3DSA:2.30.38.10 345 417 1.7E-19 T 09-03-2017 TK78_RS04645 d64fc3b6c7a19744ec7f02b8d71961c7 275 Gene3D G3DSA:1.10.10.10 217 271 1.6E-11 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS04645 d64fc3b6c7a19744ec7f02b8d71961c7 275 Pfam PF04545 Sigma-70, region 4 220 269 1.3E-18 T 09-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS04645 d64fc3b6c7a19744ec7f02b8d71961c7 275 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 46 270 8.5E-34 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS04645 d64fc3b6c7a19744ec7f02b8d71961c7 275 SUPERFAMILY SSF88659 201 271 1.85E-17 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS04645 d64fc3b6c7a19744ec7f02b8d71961c7 275 TIGRFAM TIGR02980 SigBFG: RNA polymerase sigma-70 factor, sigma-B/F/G subfamily 44 271 1.2E-87 T 09-03-2017 IPR014322 RNA polymerase sigma-B/F/G type GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS04645 d64fc3b6c7a19744ec7f02b8d71961c7 275 PIRSF PIRSF000770 31 275 5.9E-32 T 09-03-2017 IPR016263 RNA polymerase sporulation-specific sigma factor GO:0003677|GO:0006351|GO:0016987|GO:0030435 TK78_RS04645 d64fc3b6c7a19744ec7f02b8d71961c7 275 Pfam PF04542 Sigma-70 region 2 50 120 2.1E-15 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS04645 d64fc3b6c7a19744ec7f02b8d71961c7 275 Gene3D G3DSA:1.10.10.10 119 174 1.3E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS04645 d64fc3b6c7a19744ec7f02b8d71961c7 275 PRINTS PR00046 Major sigma-70 factor signature 256 267 3.3E-12 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS04645 d64fc3b6c7a19744ec7f02b8d71961c7 275 PRINTS PR00046 Major sigma-70 factor signature 75 88 3.3E-12 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS04645 d64fc3b6c7a19744ec7f02b8d71961c7 275 PRINTS PR00046 Major sigma-70 factor signature 241 256 3.3E-12 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS04645 d64fc3b6c7a19744ec7f02b8d71961c7 275 PRINTS PR00046 Major sigma-70 factor signature 224 236 3.3E-12 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS04645 d64fc3b6c7a19744ec7f02b8d71961c7 275 SUPERFAMILY SSF88659 124 196 1.26E-14 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS04645 d64fc3b6c7a19744ec7f02b8d71961c7 275 Pfam PF04539 Sigma-70 region 3 130 192 4.1E-12 T 09-03-2017 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS04645 d64fc3b6c7a19744ec7f02b8d71961c7 275 SUPERFAMILY SSF88946 14 120 5.18E-31 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS04645 d64fc3b6c7a19744ec7f02b8d71961c7 275 Gene3D G3DSA:1.10.601.10 34 118 3.5E-25 T 09-03-2017 TK78_RS04645 d64fc3b6c7a19744ec7f02b8d71961c7 275 ProSitePatterns PS00715 Sigma-70 factors family signature 1. 75 88 - T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS17270 41c8aa32d755bc973de8cfa97330e968 360 Gene3D G3DSA:3.30.360.10 190 300 9.7E-48 T 09-03-2017 TK78_RS17270 41c8aa32d755bc973de8cfa97330e968 360 SUPERFAMILY SSF55347 190 299 8.9E-35 T 09-03-2017 TK78_RS17270 41c8aa32d755bc973de8cfa97330e968 360 Pfam PF01658 Myo-inositol-1-phosphate synthase 191 300 2.1E-32 T 09-03-2017 IPR013021 Myo-inositol-1-phosphate synthase, GAPDH-like KEGG: 00521+5.5.1.4|KEGG: 00562+5.5.1.4|MetaCyc: PWY-2301|MetaCyc: PWY-4661|MetaCyc: PWY-6372|MetaCyc: PWY-6580|MetaCyc: PWY-6664|Reactome: R-HSA-1855183 TK78_RS17270 41c8aa32d755bc973de8cfa97330e968 360 PIRSF PIRSF015578 1 360 8.3E-93 T 09-03-2017 IPR002587 Myo-inositol-1-phosphate synthase GO:0004512|GO:0006021|GO:0008654 KEGG: 00521+5.5.1.4|KEGG: 00562+5.5.1.4|MetaCyc: PWY-2301|MetaCyc: PWY-4661|MetaCyc: PWY-6372|MetaCyc: PWY-6580|MetaCyc: PWY-6664|Reactome: R-HSA-1855183 TK78_RS17270 41c8aa32d755bc973de8cfa97330e968 360 SUPERFAMILY SSF51735 3 185 2.87E-92 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS17270 41c8aa32d755bc973de8cfa97330e968 360 SUPERFAMILY SSF51735 297 356 2.87E-92 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS17270 41c8aa32d755bc973de8cfa97330e968 360 Gene3D G3DSA:3.40.50.720 1 189 7.7E-115 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS17270 41c8aa32d755bc973de8cfa97330e968 360 Gene3D G3DSA:3.40.50.720 301 355 7.7E-115 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS17270 41c8aa32d755bc973de8cfa97330e968 360 TIGRFAM TIGR03450 mycothiol_INO1: inositol 1-phosphate synthase 4 354 2.8E-219 T 09-03-2017 IPR017815 Myo-inositol 1-phosphate synthase, actinobacteria TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 SUPERFAMILY SSF55048 1340 1404 6.54E-11 T 09-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 SUPERFAMILY SSF51735 1792 1979 1.82E-31 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Pfam PF00698 Acyl transferase domain 1213 1495 4.0E-43 T 09-03-2017 IPR014043 Acyl transferase TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Gene3D G3DSA:3.30.70.250 1339 1403 2.7E-8 T 09-03-2017 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 1215 1505 2.4E-77 T 09-03-2017 IPR020801 Polyketide synthase, acyl transferase domain TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1794 1969 2.5E-21 T 09-03-2017 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 SUPERFAMILY SSF47336 578 689 9.16E-20 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Pfam PF00501 AMP-binding enzyme 2609 3023 1.3E-94 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Pfam PF00501 AMP-binding enzyme 10 429 5.0E-67 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Gene3D G3DSA:1.10.1200.10 2063 2134 7.5E-20 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Gene3D G3DSA:1.10.1200.10 580 650 5.3E-17 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 SMART SM00823 Phosphopantetheine attachment site 3152 3221 0.069 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 SMART SM00823 Phosphopantetheine attachment site 2065 2136 9.1E-19 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 SMART SM00823 Phosphopantetheine attachment site 582 653 8.2E-12 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 678 920 2.3E-74 T 09-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Gene3D G3DSA:1.10.1200.10 3156 3222 2.6E-19 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Gene3D G3DSA:3.40.366.10 1404 1500 7.2E-63 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Gene3D G3DSA:3.40.366.10 1207 1335 7.2E-63 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 SUPERFAMILY SSF56801 2 533 1.14E-100 T 09-03-2017 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Gene3D G3DSA:3.30.300.30 3018 3155 6.5E-33 T 09-03-2017 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 SUPERFAMILY SSF47336 2065 2164 6.15E-19 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2091 2106 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 SMART SM01294 2066 2132 5.7E-10 T 09-03-2017 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Pfam PF00668 Condensation domain 2156 2458 2.9E-35 T 09-03-2017 IPR001242 Condensation domain TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Pfam PF00668 Condensation domain 3245 3543 4.3E-36 T 09-03-2017 IPR001242 Condensation domain TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Pfam PF13193 AMP-binding enzyme C-terminal domain 3031 3120 2.9E-10 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 SUPERFAMILY SSF56801 2597 3164 1.44E-147 T 09-03-2017 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Gene3D G3DSA:3.40.50.720 3810 3954 2.0E-5 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 SUPERFAMILY SSF53901 1069 1090 1.47E-80 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 SUPERFAMILY SSF53901 816 1040 1.47E-80 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 SUPERFAMILY SSF53901 675 789 1.47E-80 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 SUPERFAMILY SSF47336 3145 3217 7.46E-13 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 2627 3047 1.8E-116 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Gene3D G3DSA:3.40.47.10 678 932 8.4E-80 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 SMART SM00825 Beta-ketoacyl synthase 677 1094 1.4E-147 T 09-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 SUPERFAMILY SSF52777 2350 2591 7.11E-31 T 09-03-2017 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 SUPERFAMILY SSF52777 2154 2359 4.78E-32 T 09-03-2017 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 SUPERFAMILY SSF51735 1581 1777 1.55E-10 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Gene3D G3DSA:3.40.47.10 933 1094 2.1E-54 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Gene3D G3DSA:3.40.50.980 156 319 1.2E-34 T 09-03-2017 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Gene3D G3DSA:3.40.50.980 2769 2939 2.0E-43 T 09-03-2017 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 SUPERFAMILY SSF52777 3459 3675 5.23E-21 T 09-03-2017 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Gene3D G3DSA:2.30.38.10 352 423 8.5E-21 T 09-03-2017 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Gene3D G3DSA:3.40.50.720 1794 1958 1.6E-30 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 ProSitePatterns PS00455 Putative AMP-binding domain signature. 149 160 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 833 849 - T 09-03-2017 IPR018201 Beta-ketoacyl synthase, active site TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 928 1043 1.3E-38 T 09-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 SUPERFAMILY SSF52151 1405 1494 1.1E-59 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 SUPERFAMILY SSF52151 1211 1341 1.1E-59 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 1049 1160 3.8E-14 T 09-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Gene3D G3DSA:2.30.38.10 2940 3013 8.5E-22 T 09-03-2017 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Pfam PF08659 KR domain 1794 1969 8.1E-32 T 09-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Pfam PF00550 Phosphopantetheine attachment site 583 649 3.8E-15 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Pfam PF00550 Phosphopantetheine attachment site 2068 2132 5.0E-16 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Pfam PF00550 Phosphopantetheine attachment site 3154 3216 9.0E-7 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Gene3D G3DSA:3.30.300.30 424 531 5.0E-10 T 09-03-2017 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Gene3D G3DSA:3.40.50.980 2600 2768 1.1E-34 T 09-03-2017 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 SUPERFAMILY SSF52777 3243 3413 2.67E-32 T 09-03-2017 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 Gene3D G3DSA:3.40.50.980 2 155 1.1E-21 T 09-03-2017 TK78_RS00640 b573f6cd03807f001a70ea989f007b21 4051 ProSitePatterns PS00455 Putative AMP-binding domain signature. 2759 2770 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS17915 e8948b8589c351c4ef7e124103e22a49 371 Pfam PF00296 Luciferase-like monooxygenase 1 298 3.4E-58 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS17915 e8948b8589c351c4ef7e124103e22a49 371 Gene3D G3DSA:3.20.20.30 1 337 4.9E-80 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS17915 e8948b8589c351c4ef7e124103e22a49 371 SUPERFAMILY SSF51679 1 333 6.15E-72 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS17915 e8948b8589c351c4ef7e124103e22a49 371 TIGRFAM TIGR04036 LLM_CE1758_fam: putative luciferase-like monooxygenase, FMN-dependent, CE1758 family 1 355 3.7E-216 T 09-03-2017 IPR023934 Luciferase-like monooxygenase, FMN-dependent, putative TK78_RS24200 1697f8cb198f745ca1c7b159cf8ae059 384 PIRSF PIRSF016516 32 369 3.0E-89 T 09-03-2017 IPR005164 Allantoicase GO:0000256|GO:0004037 KEGG: 00230+3.5.3.4|MetaCyc: PWY-5697 TK78_RS24200 1697f8cb198f745ca1c7b159cf8ae059 384 TIGRFAM TIGR02961 allantoicase: allantoicase 45 365 8.4E-118 T 09-03-2017 IPR005164 Allantoicase GO:0000256|GO:0004037 KEGG: 00230+3.5.3.4|MetaCyc: PWY-5697 TK78_RS24200 1697f8cb198f745ca1c7b159cf8ae059 384 Hamap MF_00813 Probable allantoicase [alc]. 34 368 46.582 T 09-03-2017 IPR005164 Allantoicase GO:0000256|GO:0004037 KEGG: 00230+3.5.3.4|MetaCyc: PWY-5697 TK78_RS24200 1697f8cb198f745ca1c7b159cf8ae059 384 Gene3D G3DSA:2.60.120.260 39 217 2.6E-58 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS24200 1697f8cb198f745ca1c7b159cf8ae059 384 Gene3D G3DSA:2.60.120.260 227 366 1.6E-37 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS24200 1697f8cb198f745ca1c7b159cf8ae059 384 SUPERFAMILY SSF49785 223 368 1.15E-38 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS24200 1697f8cb198f745ca1c7b159cf8ae059 384 SUPERFAMILY SSF49785 30 217 2.72E-54 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS24200 1697f8cb198f745ca1c7b159cf8ae059 384 Pfam PF03561 Allantoicase repeat 54 213 3.2E-44 T 09-03-2017 IPR015908 Allantoicase domain GO:0000256|GO:0004037 KEGG: 00230+3.5.3.4|MetaCyc: PWY-5697 TK78_RS24200 1697f8cb198f745ca1c7b159cf8ae059 384 Pfam PF03561 Allantoicase repeat 236 365 4.4E-33 T 09-03-2017 IPR015908 Allantoicase domain GO:0000256|GO:0004037 KEGG: 00230+3.5.3.4|MetaCyc: PWY-5697 TK78_RS10440 ef9dc2a3a3906f2237ef146b6882f3d1 197 SUPERFAMILY SSF56059 5 186 3.16E-31 T 09-03-2017 TK78_RS10440 ef9dc2a3a3906f2237ef146b6882f3d1 197 Gene3D G3DSA:3.30.470.20 58 192 1.5E-21 T 09-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 TK78_RS10440 ef9dc2a3a3906f2237ef146b6882f3d1 197 Pfam PF07478 D-ala D-ala ligase C-terminus 5 180 4.4E-32 T 09-03-2017 IPR011095 D-alanine--D-alanine ligase, C-terminal GO:0008716 KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS10440 ef9dc2a3a3906f2237ef146b6882f3d1 197 Gene3D G3DSA:3.30.1490.20 4 51 3.8E-18 T 09-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 TK78_RS01280 6bae94b7058d9a63a728e59f28235e19 72 Pfam PF03621 MbtH-like protein 2 53 7.9E-30 T 09-03-2017 IPR005153 MbtH-like protein TK78_RS01280 6bae94b7058d9a63a728e59f28235e19 72 Gene3D G3DSA:3.90.820.10 10 69 3.2E-32 T 09-03-2017 TK78_RS01280 6bae94b7058d9a63a728e59f28235e19 72 SUPERFAMILY SSF160582 2 69 3.53E-32 T 09-03-2017 TK78_RS01280 6bae94b7058d9a63a728e59f28235e19 72 SMART SM00923 3 53 1.3E-33 T 09-03-2017 IPR005153 MbtH-like protein TK78_RS06415 26190433c7efe9c48ae6b06355579c91 149 Pfam PF13581 Histidine kinase-like ATPase domain 22 135 1.0E-11 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS06415 26190433c7efe9c48ae6b06355579c91 149 SUPERFAMILY SSF55874 37 138 3.44E-9 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS06415 26190433c7efe9c48ae6b06355579c91 149 Gene3D G3DSA:3.30.565.10 38 138 9.0E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS03570 70da678e39b5ec6500b22ac98a21aa6c 144 Hamap MF_00612 UPF0225 protein YchJ [ychJ]. 18 141 27.756 T 09-03-2017 IPR023006 Uncharacterised protein family UPF0225 TK78_RS03570 70da678e39b5ec6500b22ac98a21aa6c 144 Gene3D G3DSA:3.10.450.50 21 141 1.6E-40 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS03570 70da678e39b5ec6500b22ac98a21aa6c 144 SUPERFAMILY SSF54427 42 141 1.08E-32 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS08780 660d446a49e5e9d86f7069ba8bc9b052 618 Gene3D G3DSA:3.40.50.970 29 206 1.7E-70 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS08780 660d446a49e5e9d86f7069ba8bc9b052 618 SUPERFAMILY SSF52518 29 209 3.58E-59 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS08780 660d446a49e5e9d86f7069ba8bc9b052 618 Pfam PF00205 Thiamine pyrophosphate enzyme, central domain 220 355 6.8E-48 T 09-03-2017 IPR012000 Thiamine pyrophosphate enzyme, central domain GO:0000287|GO:0030976 TK78_RS08780 660d446a49e5e9d86f7069ba8bc9b052 618 SUPERFAMILY SSF52518 396 605 1.09E-67 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS08780 660d446a49e5e9d86f7069ba8bc9b052 618 Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain 31 196 2.1E-54 T 09-03-2017 IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain GO:0030976 TK78_RS08780 660d446a49e5e9d86f7069ba8bc9b052 618 Gene3D G3DSA:3.40.50.970 382 596 1.7E-76 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS08780 660d446a49e5e9d86f7069ba8bc9b052 618 ProSitePatterns PS00187 Thiamine pyrophosphate enzymes signature. 456 475 - T 09-03-2017 IPR000399 TPP-binding enzyme, conserved site GO:0000287|GO:0030976 TK78_RS08780 660d446a49e5e9d86f7069ba8bc9b052 618 SUPERFAMILY SSF52467 212 387 5.97E-63 T 09-03-2017 IPR029035 DHS-like NAD/FAD-binding domain TK78_RS08780 660d446a49e5e9d86f7069ba8bc9b052 618 TIGRFAM TIGR00118 acolac_lg: acetolactate synthase, large subunit, biosynthetic type 30 602 2.7E-229 T 09-03-2017 IPR012846 Acetolactate synthase, large subunit, biosynthetic GO:0000287|GO:0003984|GO:0009082|GO:0030976|GO:0050660 KEGG: 00290+2.2.1.6|KEGG: 00650+2.2.1.6|KEGG: 00660+2.2.1.6|KEGG: 00770+2.2.1.6|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-5938|MetaCyc: PWY-5939|MetaCyc: PWY-6389|MetaCyc: PWY-7111 TK78_RS08780 660d446a49e5e9d86f7069ba8bc9b052 618 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 419 581 4.3E-48 T 09-03-2017 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 TK78_RS08780 660d446a49e5e9d86f7069ba8bc9b052 618 Gene3D G3DSA:3.40.50.1220 213 381 7.9E-68 T 09-03-2017 IPR029035 DHS-like NAD/FAD-binding domain TK78_RS02055 9d44627289085682374eb67041328be2 259 PRINTS PR00722 Chymotrypsin serine protease family (S1) signature 114 128 4.9E-12 T 09-03-2017 IPR001314 Peptidase S1A, chymotrypsin family GO:0004252|GO:0006508 TK78_RS02055 9d44627289085682374eb67041328be2 259 PRINTS PR00722 Chymotrypsin serine protease family (S1) signature 201 213 4.9E-12 T 09-03-2017 IPR001314 Peptidase S1A, chymotrypsin family GO:0004252|GO:0006508 TK78_RS02055 9d44627289085682374eb67041328be2 259 PRINTS PR00722 Chymotrypsin serine protease family (S1) signature 59 74 4.9E-12 T 09-03-2017 IPR001314 Peptidase S1A, chymotrypsin family GO:0004252|GO:0006508 TK78_RS02055 9d44627289085682374eb67041328be2 259 SMART SM00020 36 252 6.1E-68 T 09-03-2017 IPR001254 Serine proteases, trypsin domain GO:0004252|GO:0006508 TK78_RS02055 9d44627289085682374eb67041328be2 259 ProSitePatterns PS00135 Serine proteases, trypsin family, serine active site. 202 213 - T 09-03-2017 IPR033116 Serine proteases, trypsin family, serine active site TK78_RS02055 9d44627289085682374eb67041328be2 259 Gene3D G3DSA:2.40.10.10 123 254 1.9E-38 T 09-03-2017 TK78_RS02055 9d44627289085682374eb67041328be2 259 Pfam PF00089 Trypsin 37 252 1.6E-51 T 09-03-2017 IPR001254 Serine proteases, trypsin domain GO:0004252|GO:0006508 TK78_RS02055 9d44627289085682374eb67041328be2 259 ProSitePatterns PS00134 Serine proteases, trypsin family, histidine active site. 69 74 - T 09-03-2017 IPR018114 Serine proteases, trypsin family, histidine active site GO:0004252|GO:0006508 TK78_RS02055 9d44627289085682374eb67041328be2 259 Gene3D G3DSA:2.40.10.10 67 122 5.0E-12 T 09-03-2017 TK78_RS02055 9d44627289085682374eb67041328be2 259 SUPERFAMILY SSF50494 37 254 8.22E-61 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS02055 9d44627289085682374eb67041328be2 259 Gene3D G3DSA:2.40.10.10 37 66 1.2E-12 T 09-03-2017 TK78_RS02180 34e4fd33f36a2795e8040cc22d390114 347 SUPERFAMILY SSF51679 6 331 1.96E-66 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS02180 34e4fd33f36a2795e8040cc22d390114 347 Pfam PF00296 Luciferase-like monooxygenase 6 304 1.4E-40 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS02180 34e4fd33f36a2795e8040cc22d390114 347 TIGRFAM TIGR03558 oxido_grp_1: luciferase family oxidoreductase, group 1 7 327 6.5E-104 T 09-03-2017 IPR019949 Luciferase family oxidoreductase, group 1 TK78_RS02180 34e4fd33f36a2795e8040cc22d390114 347 Gene3D G3DSA:3.20.20.30 6 327 2.3E-77 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS05970 e5fcd43ca7635ebd6a0f953488401d96 328 Pfam PF01370 NAD dependent epimerase/dehydratase family 3 250 1.2E-53 T 09-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 TK78_RS05970 e5fcd43ca7635ebd6a0f953488401d96 328 Gene3D G3DSA:3.40.50.720 1 170 1.5E-43 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS05970 e5fcd43ca7635ebd6a0f953488401d96 328 Gene3D G3DSA:3.90.25.10 171 218 1.9E-30 T 09-03-2017 TK78_RS05970 e5fcd43ca7635ebd6a0f953488401d96 328 Gene3D G3DSA:3.90.25.10 252 325 1.9E-30 T 09-03-2017 TK78_RS05970 e5fcd43ca7635ebd6a0f953488401d96 328 SUPERFAMILY SSF51735 1 317 2.43E-81 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS05970 e5fcd43ca7635ebd6a0f953488401d96 328 TIGRFAM TIGR01179 galE: UDP-glucose 4-epimerase GalE 4 323 6.7E-91 T 09-03-2017 IPR005886 UDP-glucose 4-epimerase GalE GO:0003978|GO:0006012 KEGG: 00052+5.1.3.2|KEGG: 00520+5.1.3.2|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6397|MetaCyc: PWY-6527|MetaCyc: PWY-7328|MetaCyc: PWY-7344|Reactome: R-HSA-5609977|Reactome: R-HSA-70370 TK78_RS05190 ad4edfaeae9f4953173d9c149852bc8c 435 Gene3D G3DSA:1.10.10.10 32 96 4.0E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05190 ad4edfaeae9f4953173d9c149852bc8c 435 Gene3D G3DSA:3.30.420.40 256 402 4.5E-23 T 09-03-2017 TK78_RS05190 ad4edfaeae9f4953173d9c149852bc8c 435 SUPERFAMILY SSF46785 33 95 5.29E-11 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05190 ad4edfaeae9f4953173d9c149852bc8c 435 Pfam PF00480 ROK family 166 383 1.4E-23 T 09-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 TK78_RS05190 ad4edfaeae9f4953173d9c149852bc8c 435 SUPERFAMILY SSF53067 102 237 5.67E-15 T 09-03-2017 TK78_RS05190 ad4edfaeae9f4953173d9c149852bc8c 435 Gene3D G3DSA:3.30.420.40 99 255 2.7E-22 T 09-03-2017 TK78_RS05190 ad4edfaeae9f4953173d9c149852bc8c 435 SUPERFAMILY SSF53067 244 421 2.49E-21 T 09-03-2017 TK78_RS09655 7434296ba61894d90364810df10377cb 623 SUPERFAMILY SSF51445 578 622 1.05E-79 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS09655 7434296ba61894d90364810df10377cb 623 SUPERFAMILY SSF51445 251 518 1.05E-79 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS09655 7434296ba61894d90364810df10377cb 623 Gene3D G3DSA:3.20.20.80 247 521 1.2E-82 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS09655 7434296ba61894d90364810df10377cb 623 Gene3D G3DSA:3.20.20.80 585 622 1.2E-82 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS09655 7434296ba61894d90364810df10377cb 623 Gene3D G3DSA:2.60.40.290 51 150 2.1E-36 T 09-03-2017 IPR012291 Cellulose-binding family II/chitobiase, carbohydrate-binding domain GO:0004553|GO:0030247 TK78_RS09655 7434296ba61894d90364810df10377cb 623 ProSitePatterns PS01095 Chitinases family 18 active site. 389 397 - T 09-03-2017 IPR001579 Glycoside hydrolase, chitinase active site GO:0004553|GO:0005975 KEGG: 00520+3.2.1.14|MetaCyc: PWY-6902 TK78_RS09655 7434296ba61894d90364810df10377cb 623 Pfam PF00041 Fibronectin type III domain 160 230 1.4E-7 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS09655 7434296ba61894d90364810df10377cb 623 SUPERFAMILY SSF49265 157 241 2.3E-16 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS09655 7434296ba61894d90364810df10377cb 623 Pfam PF00553 Cellulose binding domain 51 148 2.2E-31 T 09-03-2017 IPR001919 Carbohydrate-binding type-2 domain GO:0004553|GO:0005975|GO:0030246 TK78_RS09655 7434296ba61894d90364810df10377cb 623 SMART SM00060 159 233 2.2E-10 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS09655 7434296ba61894d90364810df10377cb 623 Pfam PF00704 Glycosyl hydrolases family 18 258 608 1.0E-69 T 09-03-2017 IPR001223 Glycoside hydrolase family 18, catalytic domain GO:0004553|GO:0005975 TK78_RS09655 7434296ba61894d90364810df10377cb 623 SMART SM00637 51 148 3.3E-43 T 09-03-2017 IPR001919 Carbohydrate-binding type-2 domain GO:0004553|GO:0005975|GO:0030246 TK78_RS09655 7434296ba61894d90364810df10377cb 623 SUPERFAMILY SSF49384 48 150 3.98E-32 T 09-03-2017 IPR008965 Carbohydrate-binding domain GO:0030246 TK78_RS09655 7434296ba61894d90364810df10377cb 623 Gene3D G3DSA:2.60.40.10 158 242 2.6E-22 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS09655 7434296ba61894d90364810df10377cb 623 Gene3D G3DSA:3.10.50.10 522 580 3.7E-24 T 09-03-2017 IPR029070 Chitinase insertion domain TK78_RS09655 7434296ba61894d90364810df10377cb 623 ProSitePatterns PS00561 CBM2a (carbohydrate-binding type-2) domain signature. 116 129 - T 09-03-2017 IPR018366 Carbohydrate-binding type-2, conserved site GO:0004553|GO:0005975|GO:0030246 TK78_RS09655 7434296ba61894d90364810df10377cb 623 SUPERFAMILY SSF54556 520 579 7.16E-14 T 09-03-2017 IPR029070 Chitinase insertion domain TK78_RS09655 7434296ba61894d90364810df10377cb 623 SMART SM00636 255 608 7.1E-113 T 09-03-2017 IPR011583 Chitinase II GO:0004568|GO:0006032 TK78_RS20175 4d3434ca2ab8d77355ad0f00ee1c3c5c 332 Gene3D G3DSA:3.60.10.10 48 329 2.3E-17 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS20175 4d3434ca2ab8d77355ad0f00ee1c3c5c 332 SUPERFAMILY SSF56219 48 331 1.44E-27 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS20175 4d3434ca2ab8d77355ad0f00ee1c3c5c 332 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 54 322 1.8E-15 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS19820 aa61aa052a8843ebff67cfdc90bb7281 237 Gene3D G3DSA:2.70.70.10 75 231 1.5E-46 T 09-03-2017 TK78_RS19820 aa61aa052a8843ebff67cfdc90bb7281 237 Pfam PF01551 Peptidase family M23 124 226 1.0E-31 T 09-03-2017 IPR016047 Peptidase M23 TK78_RS19820 aa61aa052a8843ebff67cfdc90bb7281 237 SUPERFAMILY SSF51261 59 230 2.04E-46 T 09-03-2017 IPR011055 Duplicated hybrid motif TK78_RS16920 0fa44f8b887a74402e9d66e1a3720cb6 584 Gene3D G3DSA:2.40.10.10 366 491 7.6E-41 T 09-03-2017 TK78_RS16920 0fa44f8b887a74402e9d66e1a3720cb6 584 SMART SM00228 488 568 9.2E-4 T 09-03-2017 IPR001478 PDZ domain GO:0005515 TK78_RS16920 0fa44f8b887a74402e9d66e1a3720cb6 584 SUPERFAMILY SSF50494 271 493 2.54E-56 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS16920 0fa44f8b887a74402e9d66e1a3720cb6 584 PRINTS PR00834 HtrA/DegQ protease family signature 330 350 7.4E-47 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS16920 0fa44f8b887a74402e9d66e1a3720cb6 584 PRINTS PR00834 HtrA/DegQ protease family signature 526 538 7.4E-47 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS16920 0fa44f8b887a74402e9d66e1a3720cb6 584 PRINTS PR00834 HtrA/DegQ protease family signature 435 452 7.4E-47 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS16920 0fa44f8b887a74402e9d66e1a3720cb6 584 PRINTS PR00834 HtrA/DegQ protease family signature 306 318 7.4E-47 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS16920 0fa44f8b887a74402e9d66e1a3720cb6 584 PRINTS PR00834 HtrA/DegQ protease family signature 372 396 7.4E-47 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS16920 0fa44f8b887a74402e9d66e1a3720cb6 584 PRINTS PR00834 HtrA/DegQ protease family signature 413 430 7.4E-47 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS16920 0fa44f8b887a74402e9d66e1a3720cb6 584 Pfam PF13365 Trypsin-like peptidase domain 297 442 6.6E-36 T 09-03-2017 TK78_RS16920 0fa44f8b887a74402e9d66e1a3720cb6 584 Gene3D G3DSA:2.40.10.10 265 365 3.0E-25 T 09-03-2017 TK78_RS16920 0fa44f8b887a74402e9d66e1a3720cb6 584 SUPERFAMILY SSF50156 469 577 2.89E-18 T 09-03-2017 IPR001478 PDZ domain GO:0005515 TK78_RS16920 0fa44f8b887a74402e9d66e1a3720cb6 584 Pfam PF13180 PDZ domain 488 577 3.9E-26 T 09-03-2017 IPR001478 PDZ domain GO:0005515 TK78_RS16920 0fa44f8b887a74402e9d66e1a3720cb6 584 Gene3D G3DSA:2.30.42.10 499 583 4.2E-19 T 09-03-2017 IPR001478 PDZ domain GO:0005515 TK78_RS04840 ddbca0e3c5c65c67d0ebf5261b3b76a7 398 Gene3D G3DSA:1.10.630.10 8 398 9.1E-132 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS04840 ddbca0e3c5c65c67d0ebf5261b3b76a7 398 PRINTS PR00359 B-class P450 signature 87 98 1.9E-47 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS04840 ddbca0e3c5c65c67d0ebf5261b3b76a7 398 PRINTS PR00359 B-class P450 signature 135 151 1.9E-47 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS04840 ddbca0e3c5c65c67d0ebf5261b3b76a7 398 PRINTS PR00359 B-class P450 signature 317 332 1.9E-47 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS04840 ddbca0e3c5c65c67d0ebf5261b3b76a7 398 PRINTS PR00359 B-class P450 signature 338 347 1.9E-47 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS04840 ddbca0e3c5c65c67d0ebf5261b3b76a7 398 PRINTS PR00359 B-class P450 signature 347 358 1.9E-47 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS04840 ddbca0e3c5c65c67d0ebf5261b3b76a7 398 PRINTS PR00359 B-class P450 signature 188 210 1.9E-47 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS04840 ddbca0e3c5c65c67d0ebf5261b3b76a7 398 PRINTS PR00359 B-class P450 signature 152 167 1.9E-47 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS04840 ddbca0e3c5c65c67d0ebf5261b3b76a7 398 PRINTS PR00359 B-class P450 signature 270 281 1.9E-47 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS04840 ddbca0e3c5c65c67d0ebf5261b3b76a7 398 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 340 349 - T 09-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 TK78_RS04840 ddbca0e3c5c65c67d0ebf5261b3b76a7 398 Pfam PF00067 Cytochrome P450 198 368 1.4E-19 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS04840 ddbca0e3c5c65c67d0ebf5261b3b76a7 398 SUPERFAMILY SSF48264 12 398 6.81E-100 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 SUPERFAMILY SSF47336 973 1075 3.01E-19 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Gene3D G3DSA:3.30.300.30 3007 3133 5.4E-34 T 09-03-2017 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Gene3D G3DSA:3.30.300.30 868 983 1.3E-26 T 09-03-2017 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Gene3D G3DSA:3.30.300.30 1932 2052 3.4E-30 T 09-03-2017 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 SUPERFAMILY SSF47336 3124 3195 8.38E-18 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 SMART SM00823 Phosphopantetheine attachment site 978 1047 2.4E-8 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 SMART SM00823 Phosphopantetheine attachment site 3130 3199 3.9E-7 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 SMART SM00823 Phosphopantetheine attachment site 2049 2118 2.1E-12 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3154 3169 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 SUPERFAMILY SSF52777 2320 2571 1.22E-57 T 09-03-2017 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 SUPERFAMILY SSF52777 201 435 2.0E-39 T 09-03-2017 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Pfam PF00975 Thioesterase domain 3218 3456 1.5E-28 T 09-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Gene3D G3DSA:3.40.50.980 624 779 4.7E-30 T 09-03-2017 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Gene3D G3DSA:3.40.50.980 1687 1838 4.8E-28 T 09-03-2017 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 SUPERFAMILY SSF52777 16 192 4.78E-33 T 09-03-2017 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 SUPERFAMILY SSF47336 2042 2115 4.32E-21 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 SUPERFAMILY SSF56801 1489 2061 2.35E-132 T 09-03-2017 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 ProSitePatterns PS00455 Putative AMP-binding domain signature. 2751 2762 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 SUPERFAMILY SSF52777 1065 1232 1.11E-43 T 09-03-2017 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 SMART SM00824 Thioesterase 3220 3461 0.0025 T 09-03-2017 IPR020802 Polyketide synthase, thioesterase domain GO:0009058|GO:0016788 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 ProSitePatterns PS00455 Putative AMP-binding domain signature. 1677 1688 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Pfam PF13193 AMP-binding enzyme C-terminal domain 880 954 8.2E-6 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Pfam PF13193 AMP-binding enzyme C-terminal domain 3021 3106 9.7E-11 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Pfam PF13193 AMP-binding enzyme C-terminal domain 1944 2022 4.0E-9 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 SUPERFAMILY SSF56801 431 991 1.44E-137 T 09-03-2017 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Pfam PF00550 Phosphopantetheine attachment site 2052 2114 3.3E-17 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Pfam PF00550 Phosphopantetheine attachment site 3132 3195 7.5E-15 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Pfam PF00550 Phosphopantetheine attachment site 981 1043 2.1E-13 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1002 1017 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 ProSitePatterns PS00455 Putative AMP-binding domain signature. 614 625 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 SUPERFAMILY SSF52777 1245 1497 1.89E-54 T 09-03-2017 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Gene3D G3DSA:3.40.50.980 2790 2921 2.4E-25 T 09-03-2017 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2073 2088 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 SUPERFAMILY SSF52777 2135 2307 5.89E-50 T 09-03-2017 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Gene3D G3DSA:3.40.50.1820 3395 3462 5.9E-51 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Gene3D G3DSA:3.40.50.1820 3204 3321 5.9E-51 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 SUPERFAMILY SSF56801 2563 3142 8.77E-127 T 09-03-2017 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Gene3D G3DSA:3.40.50.980 469 623 1.9E-48 T 09-03-2017 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Gene3D G3DSA:3.40.50.980 2608 2774 6.1E-36 T 09-03-2017 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Gene3D G3DSA:3.40.50.980 1532 1686 2.3E-40 T 09-03-2017 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Pfam PF00668 Condensation domain 1063 1356 1.3E-49 T 09-03-2017 IPR001242 Condensation domain TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Pfam PF00668 Condensation domain 12 308 1.3E-41 T 09-03-2017 IPR001242 Condensation domain TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Pfam PF00668 Condensation domain 2133 2431 1.0E-64 T 09-03-2017 IPR001242 Condensation domain TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Gene3D G3DSA:2.30.38.10 783 862 1.8E-26 T 09-03-2017 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Gene3D G3DSA:2.30.38.10 2922 3000 4.2E-22 T 09-03-2017 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Gene3D G3DSA:2.30.38.10 1848 1925 1.8E-21 T 09-03-2017 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Pfam PF00501 AMP-binding enzyme 1538 1936 5.1E-83 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Pfam PF00501 AMP-binding enzyme 474 872 6.8E-90 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Pfam PF00501 AMP-binding enzyme 2610 3011 1.6E-75 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 SUPERFAMILY SSF53474 3202 3461 3.93E-60 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 2628 3035 2.1E-102 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 1558 1960 1.2E-106 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 495 896 3.0E-118 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Gene3D G3DSA:1.10.1200.10 984 1047 4.2E-25 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Gene3D G3DSA:1.10.1200.10 2053 2118 6.0E-27 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Gene3D G3DSA:1.10.1200.10 3134 3198 9.3E-25 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Pfam PF13745 HxxPF-repeated domain 1379 1475 4.9E-30 T 09-03-2017 TK78_RS33460 461e625983f099eef2f0a446a312f99f 3473 Pfam PF13745 HxxPF-repeated domain 2453 2548 2.3E-30 T 09-03-2017 TK78_RS01120 fd6dea647d46d89d8ee96b895049356e 246 Pfam PF01177 Asp/Glu/Hydantoin racemase 7 222 5.3E-56 T 09-03-2017 IPR015942 Asp/Glu/hydantoin racemase GO:0006807|GO:0036361 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS01120 fd6dea647d46d89d8ee96b895049356e 246 Gene3D G3DSA:3.40.50.1860 2 113 8.0E-43 T 09-03-2017 IPR001920 Asp/Glu racemase GO:0008152|GO:0016855 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS01120 fd6dea647d46d89d8ee96b895049356e 246 SUPERFAMILY SSF53681 2 116 1.86E-34 T 09-03-2017 IPR001920 Asp/Glu racemase GO:0008152|GO:0016855 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS01120 fd6dea647d46d89d8ee96b895049356e 246 TIGRFAM TIGR00035 asp_race: aspartate racemase 2 235 3.2E-71 T 09-03-2017 IPR004380 Aspartate racemase GO:0006520|GO:0016855 TK78_RS01120 fd6dea647d46d89d8ee96b895049356e 246 SUPERFAMILY SSF53681 118 228 2.29E-32 T 09-03-2017 IPR001920 Asp/Glu racemase GO:0008152|GO:0016855 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS01120 fd6dea647d46d89d8ee96b895049356e 246 ProSitePatterns PS00923 Aspartate and glutamate racemases signature 1. 79 88 - T 09-03-2017 IPR018187 Asp/Glu racemase, active site 1 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS01120 fd6dea647d46d89d8ee96b895049356e 246 Gene3D G3DSA:3.40.50.1860 114 213 3.3E-34 T 09-03-2017 IPR001920 Asp/Glu racemase GO:0008152|GO:0016855 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS25995 d8a70bc3d1ef0ae635bb4a558933996c 457 PIRSF PIRSF036922 3 457 3.3E-169 T 09-03-2017 IPR014636 RNase H, phosphoglycerate mutase domain-containing TK78_RS25995 d8a70bc3d1ef0ae635bb4a558933996c 457 Gene3D G3DSA:3.40.50.1240 254 457 1.4E-57 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS25995 d8a70bc3d1ef0ae635bb4a558933996c 457 SUPERFAMILY SSF53254 254 456 1.3E-55 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS25995 d8a70bc3d1ef0ae635bb4a558933996c 457 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 256 452 6.4E-58 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS25995 d8a70bc3d1ef0ae635bb4a558933996c 457 SUPERFAMILY SSF53098 6 136 1.64E-29 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS25995 d8a70bc3d1ef0ae635bb4a558933996c 457 Gene3D G3DSA:3.30.420.10 5 141 1.3E-22 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS25995 d8a70bc3d1ef0ae635bb4a558933996c 457 SMART SM00855 255 412 1.3E-16 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS25995 d8a70bc3d1ef0ae635bb4a558933996c 457 Pfam PF13456 Reverse transcriptase-like 12 137 3.8E-16 T 09-03-2017 TK78_RS04700 756ebc78abd3c287bcfe88361d6801ca 101 SMART SM00530 20 74 1.1E-9 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS04700 756ebc78abd3c287bcfe88361d6801ca 101 SUPERFAMILY SSF47413 8 77 2.19E-16 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS04700 756ebc78abd3c287bcfe88361d6801ca 101 Gene3D G3DSA:1.10.260.40 8 75 4.4E-26 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS04700 756ebc78abd3c287bcfe88361d6801ca 101 Pfam PF13560 Helix-turn-helix domain 16 74 4.6E-12 T 09-03-2017 TK78_RS25735 eedd28d5c2b6712e2090ec75431a7dfd 214 Pfam PF07510 Protein of unknown function (DUF1524) 113 207 4.6E-9 T 09-03-2017 IPR011089 Domain of unknown function DUF1524 TK78_RS29360 6e8a99549436e4f5e457c0fa4d2c1f1a 281 Hamap MF_02113_B Proteasome subunit beta [prcB]. 7 275 50.378 T 09-03-2017 IPR022483 Peptidase T1A, proteasome beta-subunit, actinobacteria GO:0004298|GO:0005839|GO:0010498 TK78_RS29360 6e8a99549436e4f5e457c0fa4d2c1f1a 281 TIGRFAM TIGR03690 20S_bact_beta: proteasome, beta subunit 50 269 3.4E-119 T 09-03-2017 IPR022483 Peptidase T1A, proteasome beta-subunit, actinobacteria GO:0004298|GO:0005839|GO:0010498 TK78_RS29360 6e8a99549436e4f5e457c0fa4d2c1f1a 281 PRINTS PR00141 Proteasome component signature 61 76 7.6E-7 T 09-03-2017 IPR000243 Peptidase T1A, proteasome beta-subunit GO:0004175|GO:0005839|GO:0051603 Reactome: R-HSA-1169091|Reactome: R-HSA-1236974|Reactome: R-HSA-1236978|Reactome: R-HSA-174084|Reactome: R-HSA-174113|Reactome: R-HSA-174154|Reactome: R-HSA-174178|Reactome: R-HSA-174184|Reactome: R-HSA-180534|Reactome: R-HSA-180585|Reactome: R-HSA-187577|Reactome: R-HSA-195253|Reactome: R-HSA-202424|Reactome: R-HSA-211733|Reactome: R-HSA-2467813|Reactome: R-HSA-2871837|Reactome: R-HSA-349425|Reactome: R-HSA-350562|Reactome: R-HSA-450408|Reactome: R-HSA-4608870|Reactome: R-HSA-4641257|Reactome: R-HSA-4641258|Reactome: R-HSA-5358346|Reactome: R-HSA-5362768|Reactome: R-HSA-5607761|Reactome: R-HSA-5607764|Reactome: R-HSA-5610780|Reactome: R-HSA-5610783|Reactome: R-HSA-5610785|Reactome: R-HSA-5632684|Reactome: R-HSA-5658442|Reactome: R-HSA-5668541|Reactome: R-HSA-5676590|Reactome: R-HSA-5687128|Reactome: R-HSA-68827|Reactome: R-HSA-68949|Reactome: R-HSA-69017|Reactome: R-HSA-69229|Reactome: R-HSA-69481|Reactome: R-HSA-69601|Reactome: R-HSA-8852276|Reactome: R-HSA-983168 TK78_RS29360 6e8a99549436e4f5e457c0fa4d2c1f1a 281 PRINTS PR00141 Proteasome component signature 199 210 7.6E-7 T 09-03-2017 IPR000243 Peptidase T1A, proteasome beta-subunit GO:0004175|GO:0005839|GO:0051603 Reactome: R-HSA-1169091|Reactome: R-HSA-1236974|Reactome: R-HSA-1236978|Reactome: R-HSA-174084|Reactome: R-HSA-174113|Reactome: R-HSA-174154|Reactome: R-HSA-174178|Reactome: R-HSA-174184|Reactome: R-HSA-180534|Reactome: R-HSA-180585|Reactome: R-HSA-187577|Reactome: R-HSA-195253|Reactome: R-HSA-202424|Reactome: R-HSA-211733|Reactome: R-HSA-2467813|Reactome: R-HSA-2871837|Reactome: R-HSA-349425|Reactome: R-HSA-350562|Reactome: R-HSA-450408|Reactome: R-HSA-4608870|Reactome: R-HSA-4641257|Reactome: R-HSA-4641258|Reactome: R-HSA-5358346|Reactome: R-HSA-5362768|Reactome: R-HSA-5607761|Reactome: R-HSA-5607764|Reactome: R-HSA-5610780|Reactome: R-HSA-5610783|Reactome: R-HSA-5610785|Reactome: R-HSA-5632684|Reactome: R-HSA-5658442|Reactome: R-HSA-5668541|Reactome: R-HSA-5676590|Reactome: R-HSA-5687128|Reactome: R-HSA-68827|Reactome: R-HSA-68949|Reactome: R-HSA-69017|Reactome: R-HSA-69229|Reactome: R-HSA-69481|Reactome: R-HSA-69601|Reactome: R-HSA-8852276|Reactome: R-HSA-983168 TK78_RS29360 6e8a99549436e4f5e457c0fa4d2c1f1a 281 PRINTS PR00141 Proteasome component signature 188 199 7.6E-7 T 09-03-2017 IPR000243 Peptidase T1A, proteasome beta-subunit GO:0004175|GO:0005839|GO:0051603 Reactome: R-HSA-1169091|Reactome: R-HSA-1236974|Reactome: R-HSA-1236978|Reactome: R-HSA-174084|Reactome: R-HSA-174113|Reactome: R-HSA-174154|Reactome: R-HSA-174178|Reactome: R-HSA-174184|Reactome: R-HSA-180534|Reactome: R-HSA-180585|Reactome: R-HSA-187577|Reactome: R-HSA-195253|Reactome: R-HSA-202424|Reactome: R-HSA-211733|Reactome: R-HSA-2467813|Reactome: R-HSA-2871837|Reactome: R-HSA-349425|Reactome: R-HSA-350562|Reactome: R-HSA-450408|Reactome: R-HSA-4608870|Reactome: R-HSA-4641257|Reactome: R-HSA-4641258|Reactome: R-HSA-5358346|Reactome: R-HSA-5362768|Reactome: R-HSA-5607761|Reactome: R-HSA-5607764|Reactome: R-HSA-5610780|Reactome: R-HSA-5610783|Reactome: R-HSA-5610785|Reactome: R-HSA-5632684|Reactome: R-HSA-5658442|Reactome: R-HSA-5668541|Reactome: R-HSA-5676590|Reactome: R-HSA-5687128|Reactome: R-HSA-68827|Reactome: R-HSA-68949|Reactome: R-HSA-69017|Reactome: R-HSA-69229|Reactome: R-HSA-69481|Reactome: R-HSA-69601|Reactome: R-HSA-8852276|Reactome: R-HSA-983168 TK78_RS29360 6e8a99549436e4f5e457c0fa4d2c1f1a 281 Gene3D G3DSA:3.60.20.10 54 261 2.6E-56 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS29360 6e8a99549436e4f5e457c0fa4d2c1f1a 281 SUPERFAMILY SSF56235 47 263 4.48E-59 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS29360 6e8a99549436e4f5e457c0fa4d2c1f1a 281 Pfam PF00227 Proteasome subunit 52 231 7.4E-39 T 09-03-2017 IPR001353 Proteasome, subunit alpha/beta GO:0004298|GO:0005839|GO:0051603 Reactome: R-HSA-1169091|Reactome: R-HSA-1236974|Reactome: R-HSA-1236978|Reactome: R-HSA-174084|Reactome: R-HSA-174113|Reactome: R-HSA-174154|Reactome: R-HSA-174178|Reactome: R-HSA-174184|Reactome: R-HSA-180534|Reactome: R-HSA-180585|Reactome: R-HSA-187577|Reactome: R-HSA-195253|Reactome: R-HSA-202424|Reactome: R-HSA-211733|Reactome: R-HSA-2467813|Reactome: R-HSA-2871837|Reactome: R-HSA-349425|Reactome: R-HSA-350562|Reactome: R-HSA-450408|Reactome: R-HSA-4608870|Reactome: R-HSA-4641257|Reactome: R-HSA-4641258|Reactome: R-HSA-5358346|Reactome: R-HSA-5362768|Reactome: R-HSA-5607761|Reactome: R-HSA-5607764|Reactome: R-HSA-5610780|Reactome: R-HSA-5610783|Reactome: R-HSA-5610785|Reactome: R-HSA-5632684|Reactome: R-HSA-5658442|Reactome: R-HSA-5668541|Reactome: R-HSA-5676590|Reactome: R-HSA-5687128|Reactome: R-HSA-68827|Reactome: R-HSA-68949|Reactome: R-HSA-69017|Reactome: R-HSA-69229|Reactome: R-HSA-69481|Reactome: R-HSA-69601|Reactome: R-HSA-8852276|Reactome: R-HSA-983168 TK78_RS13785 e93470b424d3d356c7b731d161747799 517 Gene3D G3DSA:2.30.38.10 350 418 3.0E-22 T 09-03-2017 TK78_RS13785 e93470b424d3d356c7b731d161747799 517 Pfam PF00501 AMP-binding enzyme 16 424 4.5E-97 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS13785 e93470b424d3d356c7b731d161747799 517 SUPERFAMILY SSF56801 9 516 1.83E-146 T 09-03-2017 TK78_RS13785 e93470b424d3d356c7b731d161747799 517 Gene3D G3DSA:3.30.300.30 419 515 6.4E-29 T 09-03-2017 TK78_RS13785 e93470b424d3d356c7b731d161747799 517 ProSitePatterns PS00455 Putative AMP-binding domain signature. 181 192 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS13785 e93470b424d3d356c7b731d161747799 517 Pfam PF13193 AMP-binding enzyme C-terminal domain 433 508 8.7E-21 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS13785 e93470b424d3d356c7b731d161747799 517 Gene3D G3DSA:3.40.50.980 189 339 4.2E-39 T 09-03-2017 TK78_RS13785 e93470b424d3d356c7b731d161747799 517 Gene3D G3DSA:3.40.50.980 10 188 2.0E-37 T 09-03-2017 TK78_RS10335 5342074dc41ab1d9d227180d4496827f 323 SMART SM00382 49 233 4.3E-12 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS10335 5342074dc41ab1d9d227180d4496827f 323 Pfam PF00005 ABC transporter 41 184 5.1E-26 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS10335 5342074dc41ab1d9d227180d4496827f 323 SUPERFAMILY SSF52540 37 250 6.09E-56 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10335 5342074dc41ab1d9d227180d4496827f 323 Gene3D G3DSA:3.40.50.300 3 252 6.7E-61 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08970 cde270c87e9070dd2dc41401deb041c0 230 Gene3D G3DSA:3.40.50.300 66 173 5.4E-9 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08970 cde270c87e9070dd2dc41401deb041c0 230 SUPERFAMILY SSF52540 45 175 1.69E-12 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08970 cde270c87e9070dd2dc41401deb041c0 230 Gene3D G3DSA:3.40.50.300 28 65 8.7E-5 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08970 cde270c87e9070dd2dc41401deb041c0 230 Pfam PF13671 AAA domain 58 173 5.3E-7 T 09-03-2017 TK78_RS21750 680b16030ddad259792c1460e7e13bcd 331 SUPERFAMILY SSF88659 183 258 8.72E-15 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS21750 680b16030ddad259792c1460e7e13bcd 331 Pfam PF04539 Sigma-70 region 3 190 256 1.3E-15 T 09-03-2017 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS21750 680b16030ddad259792c1460e7e13bcd 331 PRINTS PR00046 Major sigma-70 factor signature 312 323 7.2E-11 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS21750 680b16030ddad259792c1460e7e13bcd 331 PRINTS PR00046 Major sigma-70 factor signature 297 312 7.2E-11 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS21750 680b16030ddad259792c1460e7e13bcd 331 PRINTS PR00046 Major sigma-70 factor signature 134 147 7.2E-11 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS21750 680b16030ddad259792c1460e7e13bcd 331 PRINTS PR00046 Major sigma-70 factor signature 280 292 7.2E-11 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS21750 680b16030ddad259792c1460e7e13bcd 331 Gene3D G3DSA:1.10.601.10 91 177 2.0E-24 T 09-03-2017 TK78_RS21750 680b16030ddad259792c1460e7e13bcd 331 SUPERFAMILY SSF88946 80 179 2.04E-30 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS21750 680b16030ddad259792c1460e7e13bcd 331 Gene3D G3DSA:1.10.10.10 178 233 3.4E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS21750 680b16030ddad259792c1460e7e13bcd 331 Pfam PF04542 Sigma-70 region 2 110 179 2.6E-16 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS21750 680b16030ddad259792c1460e7e13bcd 331 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 107 326 1.4E-31 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS21750 680b16030ddad259792c1460e7e13bcd 331 Pfam PF04545 Sigma-70, region 4 277 325 1.5E-17 T 09-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS21750 680b16030ddad259792c1460e7e13bcd 331 TIGRFAM TIGR02980 SigBFG: RNA polymerase sigma-70 factor, sigma-B/F/G subfamily 105 327 5.3E-92 T 09-03-2017 IPR014322 RNA polymerase sigma-B/F/G type GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS21750 680b16030ddad259792c1460e7e13bcd 331 ProSitePatterns PS00715 Sigma-70 factors family signature 1. 134 147 - T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS21750 680b16030ddad259792c1460e7e13bcd 331 SUPERFAMILY SSF88659 246 327 1.61E-15 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS21750 680b16030ddad259792c1460e7e13bcd 331 Gene3D G3DSA:1.10.10.10 273 327 9.0E-10 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS25510 4594650a8a276e8c60d7dfe47ea0b026 472 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 361 470 3.2E-18 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS25510 4594650a8a276e8c60d7dfe47ea0b026 472 Pfam PF00672 HAMP domain 183 252 1.6E-16 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS25510 4594650a8a276e8c60d7dfe47ea0b026 472 SUPERFAMILY SSF47384 239 319 3.73E-17 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS25510 4594650a8a276e8c60d7dfe47ea0b026 472 Gene3D G3DSA:1.10.287.130 246 305 2.6E-16 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS25510 4594650a8a276e8c60d7dfe47ea0b026 472 SMART SM00387 360 472 1.0E-28 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS25510 4594650a8a276e8c60d7dfe47ea0b026 472 Gene3D G3DSA:3.30.565.10 306 469 2.3E-37 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS25510 4594650a8a276e8c60d7dfe47ea0b026 472 SMART SM00388 256 319 1.6E-12 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS25510 4594650a8a276e8c60d7dfe47ea0b026 472 Pfam PF00512 His Kinase A (phospho-acceptor) domain 257 314 7.8E-14 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS25510 4594650a8a276e8c60d7dfe47ea0b026 472 SUPERFAMILY SSF55874 319 468 7.47E-35 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS25510 4594650a8a276e8c60d7dfe47ea0b026 472 SMART SM00304 203 255 6.0E-14 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS25510 4594650a8a276e8c60d7dfe47ea0b026 472 PRINTS PR00344 Bacterial sensor protein C-terminal signature 415 425 5.6E-13 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS25510 4594650a8a276e8c60d7dfe47ea0b026 472 PRINTS PR00344 Bacterial sensor protein C-terminal signature 432 450 5.6E-13 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS25510 4594650a8a276e8c60d7dfe47ea0b026 472 PRINTS PR00344 Bacterial sensor protein C-terminal signature 456 469 5.6E-13 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS25510 4594650a8a276e8c60d7dfe47ea0b026 472 PRINTS PR00344 Bacterial sensor protein C-terminal signature 397 411 5.6E-13 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS25510 4594650a8a276e8c60d7dfe47ea0b026 472 SUPERFAMILY SSF158472 204 252 1.44E-8 T 09-03-2017 TK78_RS13950 f73486f15ed6841a5a7e690409027d68 328 Gene3D G3DSA:1.10.10.60 275 323 2.0E-10 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS13950 f73486f15ed6841a5a7e690409027d68 328 Pfam PF01965 DJ-1/PfpI family 3 181 9.6E-13 T 09-03-2017 IPR002818 DJ-1/PfpI TK78_RS13950 f73486f15ed6841a5a7e690409027d68 328 Gene3D G3DSA:1.10.10.60 227 274 8.7E-13 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS13950 f73486f15ed6841a5a7e690409027d68 328 SUPERFAMILY SSF46689 273 323 1.93E-8 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS13950 f73486f15ed6841a5a7e690409027d68 328 Gene3D G3DSA:3.40.50.880 4 226 1.8E-47 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS13950 f73486f15ed6841a5a7e690409027d68 328 SMART SM00342 236 319 8.2E-25 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS13950 f73486f15ed6841a5a7e690409027d68 328 Pfam PF12833 Helix-turn-helix domain 243 320 6.4E-21 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS13950 f73486f15ed6841a5a7e690409027d68 328 SUPERFAMILY SSF52317 2 202 1.21E-44 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS13950 f73486f15ed6841a5a7e690409027d68 328 SUPERFAMILY SSF46689 224 270 4.44E-7 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS27975 e4a808df1ee6baa7063f35b7f80bb3bb 247 Pfam PF01022 Bacterial regulatory protein, arsR family 18 63 3.0E-7 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS27975 e4a808df1ee6baa7063f35b7f80bb3bb 247 SMART SM00347 9 115 0.0085 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS27975 e4a808df1ee6baa7063f35b7f80bb3bb 247 SUPERFAMILY SSF46785 19 205 6.11E-30 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS27975 e4a808df1ee6baa7063f35b7f80bb3bb 247 Gene3D G3DSA:1.10.10.10 19 122 8.3E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS20655 c381b2f29231efb25d5dbec4809b9a69 844 Gene3D G3DSA:3.40.710.10 497 729 2.0E-55 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS20655 c381b2f29231efb25d5dbec4809b9a69 844 SUPERFAMILY SSF56601 447 701 1.79E-42 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS20655 c381b2f29231efb25d5dbec4809b9a69 844 PRINTS PR00725 D-Ala-D-Ala carboxypeptidase 1 (S11) family signature 603 616 1.3E-14 T 09-03-2017 IPR018044 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A GO:0006508|GO:0009002 TK78_RS20655 c381b2f29231efb25d5dbec4809b9a69 844 PRINTS PR00725 D-Ala-D-Ala carboxypeptidase 1 (S11) family signature 576 593 1.3E-14 T 09-03-2017 IPR018044 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A GO:0006508|GO:0009002 TK78_RS20655 c381b2f29231efb25d5dbec4809b9a69 844 PRINTS PR00725 D-Ala-D-Ala carboxypeptidase 1 (S11) family signature 519 530 1.3E-14 T 09-03-2017 IPR018044 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A GO:0006508|GO:0009002 TK78_RS20655 c381b2f29231efb25d5dbec4809b9a69 844 Pfam PF00768 D-alanyl-D-alanine carboxypeptidase 507 703 3.9E-36 T 09-03-2017 IPR001967 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, N-terminal GO:0006508|GO:0009002 TK78_RS10215 ffdbe2b284720e538eacafbd87b6f6d9 148 TIGRFAM TIGR00738 rrf2_super: Rrf2 family protein 1 130 2.8E-25 T 09-03-2017 IPR000944 Transcription regulator Rrf2-type TK78_RS10215 ffdbe2b284720e538eacafbd87b6f6d9 148 Pfam PF02082 Transcriptional regulator 1 82 2.5E-17 T 09-03-2017 IPR000944 Transcription regulator Rrf2-type TK78_RS10215 ffdbe2b284720e538eacafbd87b6f6d9 148 Gene3D G3DSA:1.10.10.10 1 131 1.2E-30 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS10215 ffdbe2b284720e538eacafbd87b6f6d9 148 SUPERFAMILY SSF46785 2 132 1.42E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS30805 6573ff478c681e3a479428cecdaeb9ff 961 Pfam PF02347 Glycine cleavage system P-protein 453 736 2.9E-12 T 09-03-2017 IPR020580 Glycine cleavage system P-protein, N-terminal GO:0004375|GO:0006546|GO:0055114 KEGG: 00260+1.4.4.2|Reactome: R-HSA-6783984 TK78_RS30805 6573ff478c681e3a479428cecdaeb9ff 961 Pfam PF02347 Glycine cleavage system P-protein 19 447 1.2E-179 T 09-03-2017 IPR020580 Glycine cleavage system P-protein, N-terminal GO:0004375|GO:0006546|GO:0055114 KEGG: 00260+1.4.4.2|Reactome: R-HSA-6783984 TK78_RS30805 6573ff478c681e3a479428cecdaeb9ff 961 TIGRFAM TIGR00461 gcvP: glycine dehydrogenase 20 953 0.0 T 09-03-2017 IPR003437 Glycine dehydrogenase (decarboxylating) GO:0004375|GO:0006544|GO:0055114 KEGG: 00260+1.4.4.2|Reactome: R-HSA-6783984 TK78_RS30805 6573ff478c681e3a479428cecdaeb9ff 961 SUPERFAMILY SSF53383 932 955 3.94E-98 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS30805 6573ff478c681e3a479428cecdaeb9ff 961 SUPERFAMILY SSF53383 464 890 3.94E-98 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS30805 6573ff478c681e3a479428cecdaeb9ff 961 Gene3D G3DSA:3.40.640.10 94 310 2.7E-18 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS30805 6573ff478c681e3a479428cecdaeb9ff 961 Gene3D G3DSA:3.40.640.10 505 745 1.8E-38 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS30805 6573ff478c681e3a479428cecdaeb9ff 961 Hamap MF_00711 Glycine dehydrogenase (decarboxylating) [gcvP]. 11 959 25.54 T 09-03-2017 IPR003437 Glycine dehydrogenase (decarboxylating) GO:0004375|GO:0006544|GO:0055114 KEGG: 00260+1.4.4.2|Reactome: R-HSA-6783984 TK78_RS30805 6573ff478c681e3a479428cecdaeb9ff 961 SUPERFAMILY SSF53383 20 447 1.02E-102 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS15425 b0724dca64a99b6edf113895b8f87e3e 224 SUPERFAMILY SSF46785 145 222 2.93E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS15425 b0724dca64a99b6edf113895b8f87e3e 224 Pfam PF00027 Cyclic nucleotide-binding domain 29 110 2.9E-25 T 09-03-2017 IPR000595 Cyclic nucleotide-binding domain TK78_RS15425 b0724dca64a99b6edf113895b8f87e3e 224 Gene3D G3DSA:2.60.120.10 2 145 1.6E-40 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS15425 b0724dca64a99b6edf113895b8f87e3e 224 SMART SM00419 167 215 2.1E-13 T 09-03-2017 IPR012318 Crp-type HTH domain GO:0003677|GO:0006355 TK78_RS15425 b0724dca64a99b6edf113895b8f87e3e 224 PRINTS PR00103 cAMP-dependent protein kinase signature 31 45 1.8E-6 T 09-03-2017 TK78_RS15425 b0724dca64a99b6edf113895b8f87e3e 224 PRINTS PR00103 cAMP-dependent protein kinase signature 46 60 1.8E-6 T 09-03-2017 TK78_RS15425 b0724dca64a99b6edf113895b8f87e3e 224 PRINTS PR00103 cAMP-dependent protein kinase signature 76 85 1.8E-6 T 09-03-2017 TK78_RS15425 b0724dca64a99b6edf113895b8f87e3e 224 PRINTS PR00103 cAMP-dependent protein kinase signature 88 99 1.8E-6 T 09-03-2017 TK78_RS15425 b0724dca64a99b6edf113895b8f87e3e 224 SMART SM00100 10 128 1.3E-26 T 09-03-2017 IPR000595 Cyclic nucleotide-binding domain TK78_RS15425 b0724dca64a99b6edf113895b8f87e3e 224 Gene3D G3DSA:1.10.10.10 146 222 6.5E-27 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS15425 b0724dca64a99b6edf113895b8f87e3e 224 Pfam PF13545 Crp-like helix-turn-helix domain 148 221 4.3E-17 T 09-03-2017 IPR012318 Crp-type HTH domain GO:0003677|GO:0006355 TK78_RS15425 b0724dca64a99b6edf113895b8f87e3e 224 ProSitePatterns PS00889 Cyclic nucleotide-binding domain signature 2. 78 95 - T 09-03-2017 IPR018488 Cyclic nucleotide-binding, conserved site TK78_RS15425 b0724dca64a99b6edf113895b8f87e3e 224 SUPERFAMILY SSF51206 3 142 4.84E-39 T 09-03-2017 IPR018490 Cyclic nucleotide-binding-like TK78_RS06565 fe4d928e92971be24083fc1631caeb4f 344 SUPERFAMILY SSF52540 24 272 3.51E-74 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06565 fe4d928e92971be24083fc1631caeb4f 344 Gene3D G3DSA:3.40.50.300 23 274 3.2E-82 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06565 fe4d928e92971be24083fc1631caeb4f 344 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 250 339 5.2E-24 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS06565 fe4d928e92971be24083fc1631caeb4f 344 ProSitePatterns PS00211 ABC transporters family signature. 173 187 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS06565 fe4d928e92971be24083fc1631caeb4f 344 Pfam PF00005 ABC transporter 51 200 1.9E-30 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS06565 fe4d928e92971be24083fc1631caeb4f 344 SMART SM00382 59 258 1.4E-14 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS06565 fe4d928e92971be24083fc1631caeb4f 344 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 252 319 8.6E-16 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS12930 1487f5a590b5cd401991ea724a20f1bf 116 SUPERFAMILY SSF54909 1 112 1.93E-25 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS12930 1487f5a590b5cd401991ea724a20f1bf 116 Gene3D G3DSA:3.30.70.1060 1 114 2.2E-34 T 09-03-2017 TK78_RS12930 1487f5a590b5cd401991ea724a20f1bf 116 Pfam PF03795 YCII-related domain 1 114 6.7E-21 T 09-03-2017 IPR005545 YCII-related TK78_RS12660 5ba30d800078f52c7e4bff9aacecdffd 626 Pfam PF05199 GMC oxidoreductase 495 552 8.0E-14 T 09-03-2017 IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal GO:0016614|GO:0055114 Reactome: R-HSA-6798163 TK78_RS12660 5ba30d800078f52c7e4bff9aacecdffd 626 Pfam PF00732 GMC oxidoreductase 25 304 1.9E-10 T 09-03-2017 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal GO:0016614|GO:0050660|GO:0055114 Reactome: R-HSA-6798163 TK78_RS12660 5ba30d800078f52c7e4bff9aacecdffd 626 SUPERFAMILY SSF51905 22 185 9.55E-45 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS12660 5ba30d800078f52c7e4bff9aacecdffd 626 SUPERFAMILY SSF51905 497 557 9.55E-45 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS12660 5ba30d800078f52c7e4bff9aacecdffd 626 SUPERFAMILY SSF51905 215 330 9.55E-45 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS12660 5ba30d800078f52c7e4bff9aacecdffd 626 Gene3D G3DSA:3.50.50.60 24 145 9.2E-84 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS12660 5ba30d800078f52c7e4bff9aacecdffd 626 Gene3D G3DSA:3.50.50.60 223 328 9.2E-84 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS12660 5ba30d800078f52c7e4bff9aacecdffd 626 Gene3D G3DSA:3.50.50.60 491 559 9.2E-84 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS12660 5ba30d800078f52c7e4bff9aacecdffd 626 Gene3D G3DSA:3.50.50.60 361 374 9.2E-84 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS24260 55140a4b17900757fda7fb0fbb97962d 226 Gene3D G3DSA:1.10.260.40 13 75 2.3E-6 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS24260 55140a4b17900757fda7fb0fbb97962d 226 SMART SM00530 11 73 0.4 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS24260 55140a4b17900757fda7fb0fbb97962d 226 SMART SM00530 79 135 0.0081 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS24260 55140a4b17900757fda7fb0fbb97962d 226 Gene3D G3DSA:1.10.260.40 80 138 8.9E-4 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS24260 55140a4b17900757fda7fb0fbb97962d 226 SUPERFAMILY SSF47413 79 137 1.63E-5 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS25450 3fa6d140d5438873b73c97089a058470 420 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 261 375 8.2E-33 T 09-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal TK78_RS25450 3fa6d140d5438873b73c97089a058470 420 SUPERFAMILY SSF53901 6 258 3.51E-66 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS25450 3fa6d140d5438873b73c97089a058470 420 TIGRFAM TIGR03150 fabF: beta-ketoacyl-acyl-carrier-protein synthase II 6 418 6.5E-150 T 09-03-2017 IPR017568 3-oxoacyl-[acyl-carrier-protein] synthase 2 GO:0006633|GO:0016747 TK78_RS25450 3fa6d140d5438873b73c97089a058470 420 Gene3D G3DSA:3.40.47.10 270 419 1.7E-50 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS25450 3fa6d140d5438873b73c97089a058470 420 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 6 253 7.1E-54 T 09-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal TK78_RS25450 3fa6d140d5438873b73c97089a058470 420 SMART SM00825 Beta-ketoacyl synthase 8 411 1.0E-12 T 09-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TK78_RS25450 3fa6d140d5438873b73c97089a058470 420 PIRSF PIRSF000447 3 420 1.4E-141 T 09-03-2017 IPR017568 3-oxoacyl-[acyl-carrier-protein] synthase 2 GO:0006633|GO:0016747 TK78_RS25450 3fa6d140d5438873b73c97089a058470 420 Gene3D G3DSA:3.40.47.10 10 266 1.3E-66 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS25450 3fa6d140d5438873b73c97089a058470 420 SUPERFAMILY SSF53901 221 419 2.0E-62 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS17300 15a684e1eb85d5784e15285214350f38 238 Gene3D G3DSA:1.10.10.10 124 183 3.9E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS17300 15a684e1eb85d5784e15285214350f38 238 Pfam PF08281 Sigma-70, region 4 129 181 1.3E-14 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS17300 15a684e1eb85d5784e15285214350f38 238 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 24 181 2.7E-30 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS17300 15a684e1eb85d5784e15285214350f38 238 SUPERFAMILY SSF88659 123 182 4.8E-15 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS17300 15a684e1eb85d5784e15285214350f38 238 Gene3D G3DSA:1.10.1740.10 6 117 6.0E-33 T 09-03-2017 TK78_RS17300 15a684e1eb85d5784e15285214350f38 238 Pfam PF04542 Sigma-70 region 2 29 96 3.1E-18 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS17300 15a684e1eb85d5784e15285214350f38 238 SUPERFAMILY SSF88946 6 114 2.94E-30 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12155 c2114a2eb93671b892fa7f565760827c 1094 PRINTS PR00723 Subtilisin serine protease family (S8) signature 207 226 5.5E-20 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS12155 c2114a2eb93671b892fa7f565760827c 1094 PRINTS PR00723 Subtilisin serine protease family (S8) signature 244 257 5.5E-20 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS12155 c2114a2eb93671b892fa7f565760827c 1094 PRINTS PR00723 Subtilisin serine protease family (S8) signature 424 440 5.5E-20 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS12155 c2114a2eb93671b892fa7f565760827c 1094 Gene3D G3DSA:3.40.50.200 191 481 1.4E-93 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS12155 c2114a2eb93671b892fa7f565760827c 1094 PIRSF PIRSF037854 1 1094 0.0 T 09-03-2017 IPR017297 Peptidase S8A, DPH-A TK78_RS12155 c2114a2eb93671b892fa7f565760827c 1094 SUPERFAMILY SSF52743 189 482 8.51E-88 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS12155 c2114a2eb93671b892fa7f565760827c 1094 Gene3D G3DSA:2.60.40.680 1011 1079 3.8E-4 T 09-03-2017 IPR002102 Cellulosome anchoring protein, cohesin domain GO:0000272|GO:0030246 TK78_RS12155 c2114a2eb93671b892fa7f565760827c 1094 Pfam PF00082 Subtilase family 207 473 6.7E-62 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS12155 c2114a2eb93671b892fa7f565760827c 1094 ProSitePatterns PS00138 Serine proteases, subtilase family, serine active site. 425 435 - T 09-03-2017 IPR023828 Peptidase S8, subtilisin, Ser-active site TK78_RS12155 c2114a2eb93671b892fa7f565760827c 1094 ProSitePatterns PS00137 Serine proteases, subtilase family, histidine active site. 248 258 - T 09-03-2017 IPR022398 Peptidase S8, subtilisin, His-active site TK78_RS21135 d0ba2a7cb1f8f8e4b37bad56a7523f42 218 SUPERFAMILY SSF52172 7 133 1.28E-13 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS21135 d0ba2a7cb1f8f8e4b37bad56a7523f42 218 Pfam PF00196 Bacterial regulatory proteins, luxR family 147 187 2.3E-6 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS21135 d0ba2a7cb1f8f8e4b37bad56a7523f42 218 Pfam PF00072 Response regulator receiver domain 9 118 1.3E-11 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS21135 d0ba2a7cb1f8f8e4b37bad56a7523f42 218 Gene3D G3DSA:3.40.50.2300 7 149 1.9E-13 T 09-03-2017 TK78_RS21135 d0ba2a7cb1f8f8e4b37bad56a7523f42 218 SUPERFAMILY SSF46894 141 214 7.48E-9 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS21135 d0ba2a7cb1f8f8e4b37bad56a7523f42 218 Gene3D G3DSA:1.10.10.10 150 213 4.1E-11 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS21135 d0ba2a7cb1f8f8e4b37bad56a7523f42 218 SMART SM00448 7 119 8.2E-10 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS22950 292049449bf338d80307ccc094e7b9ab 208 Pfam PF00440 Bacterial regulatory proteins, tetR family 24 68 1.2E-13 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS22950 292049449bf338d80307ccc094e7b9ab 208 SUPERFAMILY SSF48498 92 206 5.04E-10 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS22950 292049449bf338d80307ccc094e7b9ab 208 SUPERFAMILY SSF46689 15 90 1.69E-17 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS22950 292049449bf338d80307ccc094e7b9ab 208 Gene3D G3DSA:1.10.357.10 18 206 1.2E-35 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS22950 292049449bf338d80307ccc094e7b9ab 208 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 45 68 1.7E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS22950 292049449bf338d80307ccc094e7b9ab 208 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 24 37 1.7E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS27995 5af6f4a85218dbf19b448d3c2fadb953 254 Gene3D G3DSA:3.40.50.300 3 235 8.0E-45 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27995 5af6f4a85218dbf19b448d3c2fadb953 254 Pfam PF00005 ABC transporter 23 174 5.5E-21 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS27995 5af6f4a85218dbf19b448d3c2fadb953 254 SMART SM00382 32 233 6.7E-4 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS27995 5af6f4a85218dbf19b448d3c2fadb953 254 TIGRFAM TIGR01978 sufC: FeS assembly ATPase SufC 4 245 9.1E-104 T 09-03-2017 IPR010230 FeS cluster assembly SUF system, ATPase SufC GO:0005524|GO:0006810 TK78_RS27995 5af6f4a85218dbf19b448d3c2fadb953 254 SUPERFAMILY SSF52540 4 233 6.48E-40 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS25970 0b7ae536e9c466e7fb3cc49eea429546 315 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 163 191 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS25970 0b7ae536e9c466e7fb3cc49eea429546 315 Gene3D G3DSA:3.40.50.720 6 276 1.5E-70 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS25970 0b7ae536e9c466e7fb3cc49eea429546 315 Pfam PF00106 short chain dehydrogenase 12 214 7.3E-42 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS25970 0b7ae536e9c466e7fb3cc49eea429546 315 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 10 236 0.0027 T 09-03-2017 TK78_RS25970 0b7ae536e9c466e7fb3cc49eea429546 315 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 176 195 2.1E-21 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS25970 0b7ae536e9c466e7fb3cc49eea429546 315 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 197 214 2.1E-21 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS25970 0b7ae536e9c466e7fb3cc49eea429546 315 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 96 107 2.1E-21 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS25970 0b7ae536e9c466e7fb3cc49eea429546 315 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 11 28 2.1E-21 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS25970 0b7ae536e9c466e7fb3cc49eea429546 315 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 150 166 2.1E-21 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS25970 0b7ae536e9c466e7fb3cc49eea429546 315 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 176 195 4.4E-12 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS25970 0b7ae536e9c466e7fb3cc49eea429546 315 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 96 107 4.4E-12 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS25970 0b7ae536e9c466e7fb3cc49eea429546 315 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 156 164 4.4E-12 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS25970 0b7ae536e9c466e7fb3cc49eea429546 315 SUPERFAMILY SSF51735 5 268 2.98E-64 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS15300 d796c501f3a3acdbe183219a8727b7c8 511 SUPERFAMILY SSF53335 161 295 7.63E-25 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS15300 d796c501f3a3acdbe183219a8727b7c8 511 ProSitePatterns PS00092 N-6 Adenine-specific DNA methylases signature. 230 236 - T 09-03-2017 IPR002052 DNA methylase, N-6 adenine-specific, conserved site GO:0003676|GO:0008168|GO:0032259 TK78_RS15300 d796c501f3a3acdbe183219a8727b7c8 511 Pfam PF05175 Methyltransferase small domain 163 279 1.2E-13 T 09-03-2017 IPR007848 Methyltransferase small domain GO:0008168 TK78_RS15300 d796c501f3a3acdbe183219a8727b7c8 511 Gene3D G3DSA:3.40.50.150 159 295 2.2E-28 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS19475 90ab08d4344cbe9e0a29447378110a25 226 Pfam PF01636 Phosphotransferase enzyme family 74 177 4.2E-11 T 09-03-2017 IPR002575 Aminoglycoside phosphotransferase TK78_RS19475 90ab08d4344cbe9e0a29447378110a25 226 Gene3D G3DSA:3.90.1200.10 76 165 2.6E-9 T 09-03-2017 TK78_RS19475 90ab08d4344cbe9e0a29447378110a25 226 SUPERFAMILY SSF56112 5 193 6.83E-24 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS14100 62f14f9b155e2041117dac22b5fb965a 252 SMART SM00382 48 242 1.1E-10 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS14100 62f14f9b155e2041117dac22b5fb965a 252 Pfam PF00005 ABC transporter 39 187 2.3E-35 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS14100 62f14f9b155e2041117dac22b5fb965a 252 SUPERFAMILY SSF52540 23 239 1.73E-68 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS14100 62f14f9b155e2041117dac22b5fb965a 252 ProSitePatterns PS00211 ABC transporters family signature. 160 174 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS14100 62f14f9b155e2041117dac22b5fb965a 252 Gene3D G3DSA:3.40.50.300 22 242 1.3E-71 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS25950 e37eb0bc2dce56f3575ab94ba90dd7d5 410 Gene3D G3DSA:3.40.47.10 153 193 2.9E-27 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS25950 e37eb0bc2dce56f3575ab94ba90dd7d5 410 Gene3D G3DSA:3.40.47.10 259 395 2.9E-27 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS25950 e37eb0bc2dce56f3575ab94ba90dd7d5 410 SUPERFAMILY SSF53901 3 241 5.98E-50 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS25950 e37eb0bc2dce56f3575ab94ba90dd7d5 410 Pfam PF00108 Thiolase, N-terminal domain 4 233 3.9E-21 T 09-03-2017 IPR020616 Thiolase, N-terminal GO:0008152|GO:0016747 TK78_RS25950 e37eb0bc2dce56f3575ab94ba90dd7d5 410 PIRSF PIRSF000429 1 399 2.2E-67 T 09-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 TK78_RS25950 e37eb0bc2dce56f3575ab94ba90dd7d5 410 Pfam PF02803 Thiolase, C-terminal domain 277 375 5.1E-10 T 09-03-2017 IPR020617 Thiolase, C-terminal GO:0008152|GO:0016747 TK78_RS25950 e37eb0bc2dce56f3575ab94ba90dd7d5 410 ProSitePatterns PS00098 Thiolases acyl-enzyme intermediate signature. 77 95 - T 09-03-2017 IPR020615 Thiolase, acyl-enzyme intermediate active site GO:0008152|GO:0016747 TK78_RS25950 e37eb0bc2dce56f3575ab94ba90dd7d5 410 SUPERFAMILY SSF53901 265 388 2.2E-30 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS25950 e37eb0bc2dce56f3575ab94ba90dd7d5 410 Gene3D G3DSA:3.40.47.10 212 233 2.1E-30 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS25950 e37eb0bc2dce56f3575ab94ba90dd7d5 410 Gene3D G3DSA:3.40.47.10 20 116 2.1E-30 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS25950 e37eb0bc2dce56f3575ab94ba90dd7d5 410 ProSitePatterns PS00737 Thiolases signature 2. 339 355 - T 09-03-2017 IPR020613 Thiolase, conserved site GO:0008152|GO:0016747 TK78_RS17845 971600cf5d3f4cf77b991e2653f3a302 433 SMART SM00304 127 180 2.1E-7 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS17845 971600cf5d3f4cf77b991e2653f3a302 433 SUPERFAMILY SSF47384 166 246 4.71E-15 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS17845 971600cf5d3f4cf77b991e2653f3a302 433 Pfam PF00512 His Kinase A (phospho-acceptor) domain 181 246 8.0E-12 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS17845 971600cf5d3f4cf77b991e2653f3a302 433 SUPERFAMILY SSF55874 294 414 2.23E-22 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS17845 971600cf5d3f4cf77b991e2653f3a302 433 SUPERFAMILY SSF158472 128 178 3.79E-5 T 09-03-2017 TK78_RS17845 971600cf5d3f4cf77b991e2653f3a302 433 Gene3D G3DSA:3.30.565.10 234 415 1.0E-24 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS17845 971600cf5d3f4cf77b991e2653f3a302 433 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 308 412 3.5E-14 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS17845 971600cf5d3f4cf77b991e2653f3a302 433 SMART SM00387 304 413 4.9E-26 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS17845 971600cf5d3f4cf77b991e2653f3a302 433 PRINTS PR00344 Bacterial sensor protein C-terminal signature 356 366 1.3E-7 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS17845 971600cf5d3f4cf77b991e2653f3a302 433 PRINTS PR00344 Bacterial sensor protein C-terminal signature 397 410 1.3E-7 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS17845 971600cf5d3f4cf77b991e2653f3a302 433 PRINTS PR00344 Bacterial sensor protein C-terminal signature 372 390 1.3E-7 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS17845 971600cf5d3f4cf77b991e2653f3a302 433 SMART SM00388 181 246 1.8E-14 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS17845 971600cf5d3f4cf77b991e2653f3a302 433 Pfam PF00672 HAMP domain 108 176 1.7E-11 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS17845 971600cf5d3f4cf77b991e2653f3a302 433 Gene3D G3DSA:1.10.287.130 174 233 6.0E-11 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS11500 44682741459decd57ab2d7a0c79926fe 177 Hamap MF_01676 Alkyl hydroperoxide reductase AhpD [ahpD]. 1 177 86.315 T 09-03-2017 IPR004674 Alkylhydroperoxidase AhpD GO:0006979|GO:0032843|GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 TK78_RS11500 44682741459decd57ab2d7a0c79926fe 177 Pfam PF02627 Carboxymuconolactone decarboxylase family 94 176 3.7E-16 T 09-03-2017 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 TK78_RS11500 44682741459decd57ab2d7a0c79926fe 177 TIGRFAM TIGR00777 ahpD: alkylhydroperoxidase, AhpD family 3 176 1.8E-93 T 09-03-2017 IPR004674 Alkylhydroperoxidase AhpD GO:0006979|GO:0032843|GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 TK78_RS11500 44682741459decd57ab2d7a0c79926fe 177 TIGRFAM TIGR00778 ahpD_dom: alkylhydroperoxidase AhpD family core domain 112 160 3.4E-20 T 09-03-2017 IPR004675 Alkylhydroperoxidase AhpD core GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 TK78_RS11500 44682741459decd57ab2d7a0c79926fe 177 SUPERFAMILY SSF69118 3 171 1.31E-48 T 09-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 TK78_RS11500 44682741459decd57ab2d7a0c79926fe 177 Gene3D G3DSA:1.20.1290.10 1 171 2.9E-58 T 09-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 TK78_RS30180 59721ee9fa702a7c0afdb59192ca90af 206 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 146 160 3.4E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS30180 59721ee9fa702a7c0afdb59192ca90af 206 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 160 176 3.4E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS30180 59721ee9fa702a7c0afdb59192ca90af 206 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 176 188 3.4E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS30180 59721ee9fa702a7c0afdb59192ca90af 206 ProSitePatterns PS00622 LuxR-type HTH domain signature. 160 187 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS30180 59721ee9fa702a7c0afdb59192ca90af 206 Pfam PF00196 Bacterial regulatory proteins, luxR family 145 198 6.1E-18 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS30180 59721ee9fa702a7c0afdb59192ca90af 206 Gene3D G3DSA:3.40.50.2300 1 120 4.4E-37 T 09-03-2017 TK78_RS30180 59721ee9fa702a7c0afdb59192ca90af 206 Pfam PF00072 Response regulator receiver domain 4 116 4.3E-26 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS30180 59721ee9fa702a7c0afdb59192ca90af 206 SMART SM00448 2 115 2.3E-30 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS30180 59721ee9fa702a7c0afdb59192ca90af 206 Gene3D G3DSA:1.10.10.10 121 206 8.8E-32 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS30180 59721ee9fa702a7c0afdb59192ca90af 206 SUPERFAMILY SSF52172 1 134 1.42E-34 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS30180 59721ee9fa702a7c0afdb59192ca90af 206 SUPERFAMILY SSF46894 128 206 2.11E-22 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS30180 59721ee9fa702a7c0afdb59192ca90af 206 SMART SM00421 143 200 4.9E-25 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS30355 d384a07f470a1a8734785b57808110bf 402 Gene3D G3DSA:3.30.300.10 11 143 4.6E-45 T 09-03-2017 TK78_RS30355 d384a07f470a1a8734785b57808110bf 402 SUPERFAMILY SSF55973 120 248 3.77E-45 T 09-03-2017 IPR022636 S-adenosylmethionine synthetase superfamily GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 TK78_RS30355 d384a07f470a1a8734785b57808110bf 402 Pfam PF02773 S-adenosylmethionine synthetase, C-terminal domain 250 389 9.0E-68 T 09-03-2017 IPR022630 S-adenosylmethionine synthetase, C-terminal GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 TK78_RS30355 d384a07f470a1a8734785b57808110bf 402 PIRSF PIRSF000497 1 401 8.7E-164 T 09-03-2017 IPR002133 S-adenosylmethionine synthetase GO:0004478|GO:0005524|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 TK78_RS30355 d384a07f470a1a8734785b57808110bf 402 Gene3D G3DSA:3.30.300.10 144 250 5.4E-38 T 09-03-2017 TK78_RS30355 d384a07f470a1a8734785b57808110bf 402 SUPERFAMILY SSF55973 3 109 1.22E-44 T 09-03-2017 IPR022636 S-adenosylmethionine synthetase superfamily GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 TK78_RS30355 d384a07f470a1a8734785b57808110bf 402 Pfam PF02772 S-adenosylmethionine synthetase, central domain 124 248 3.5E-44 T 09-03-2017 IPR022629 S-adenosylmethionine synthetase, central domain GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 TK78_RS30355 d384a07f470a1a8734785b57808110bf 402 Pfam PF00438 S-adenosylmethionine synthetase, N-terminal domain 4 101 2.0E-40 T 09-03-2017 IPR022628 S-adenosylmethionine synthetase, N-terminal GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 TK78_RS30355 d384a07f470a1a8734785b57808110bf 402 ProSitePatterns PS00377 S-adenosylmethionine synthase signature 2. 276 284 - T 09-03-2017 IPR022631 S-adenosylmethionine synthetase, conserved site GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 TK78_RS30355 d384a07f470a1a8734785b57808110bf 402 SUPERFAMILY SSF55973 250 400 1.92E-67 T 09-03-2017 IPR022636 S-adenosylmethionine synthetase superfamily GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 TK78_RS30355 d384a07f470a1a8734785b57808110bf 402 TIGRFAM TIGR01034 metK: methionine adenosyltransferase 5 399 6.2E-170 T 09-03-2017 IPR002133 S-adenosylmethionine synthetase GO:0004478|GO:0005524|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 TK78_RS30355 d384a07f470a1a8734785b57808110bf 402 ProSitePatterns PS00376 S-adenosylmethionine synthase signature 1. 126 136 - T 09-03-2017 IPR022631 S-adenosylmethionine synthetase, conserved site GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 TK78_RS30355 d384a07f470a1a8734785b57808110bf 402 Hamap MF_00086 S-adenosylmethionine synthase [metK]. 2 400 56.997 T 09-03-2017 IPR002133 S-adenosylmethionine synthetase GO:0004478|GO:0005524|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 TK78_RS30355 d384a07f470a1a8734785b57808110bf 402 Gene3D G3DSA:3.30.300.10 261 400 1.6E-69 T 09-03-2017 TK78_RS09775 a2f01ed926a4f7ac5a4e2ee41f934a22 463 Gene3D G3DSA:2.40.37.10 314 462 6.9E-49 T 09-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 TK78_RS09775 a2f01ed926a4f7ac5a4e2ee41f934a22 463 Pfam PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 71 327 6.6E-67 T 09-03-2017 IPR022644 Orn/DAP/Arg decarboxylase 2, N-terminal GO:0003824 TK78_RS09775 a2f01ed926a4f7ac5a4e2ee41f934a22 463 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 419 432 3.5E-17 T 09-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TK78_RS09775 a2f01ed926a4f7ac5a4e2ee41f934a22 463 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 93 111 3.5E-17 T 09-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TK78_RS09775 a2f01ed926a4f7ac5a4e2ee41f934a22 463 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 228 241 3.5E-17 T 09-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TK78_RS09775 a2f01ed926a4f7ac5a4e2ee41f934a22 463 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 113 125 3.5E-17 T 09-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TK78_RS09775 a2f01ed926a4f7ac5a4e2ee41f934a22 463 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 317 336 3.5E-17 T 09-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TK78_RS09775 a2f01ed926a4f7ac5a4e2ee41f934a22 463 Pfam PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 323 438 1.6E-15 T 09-03-2017 IPR022643 Orn/DAP/Arg decarboxylase 2, C-terminal GO:0003824 TK78_RS09775 a2f01ed926a4f7ac5a4e2ee41f934a22 463 ProSitePatterns PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. 93 111 - T 09-03-2017 IPR022653 Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site TK78_RS09775 a2f01ed926a4f7ac5a4e2ee41f934a22 463 ProSitePatterns PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 267 280 - T 09-03-2017 IPR022657 Orn/DAP/Arg decarboxylase 2, conserved site TK78_RS09775 a2f01ed926a4f7ac5a4e2ee41f934a22 463 Gene3D G3DSA:3.20.20.10 72 313 3.6E-93 T 09-03-2017 IPR029066 PLP-binding barrel TK78_RS09775 a2f01ed926a4f7ac5a4e2ee41f934a22 463 PRINTS PR01181 Diaminopimelate decarboxylase signature 200 209 1.1E-24 T 09-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS09775 a2f01ed926a4f7ac5a4e2ee41f934a22 463 PRINTS PR01181 Diaminopimelate decarboxylase signature 111 128 1.1E-24 T 09-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS09775 a2f01ed926a4f7ac5a4e2ee41f934a22 463 PRINTS PR01181 Diaminopimelate decarboxylase signature 429 451 1.1E-24 T 09-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS09775 a2f01ed926a4f7ac5a4e2ee41f934a22 463 PRINTS PR01181 Diaminopimelate decarboxylase signature 346 364 1.1E-24 T 09-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS09775 a2f01ed926a4f7ac5a4e2ee41f934a22 463 SUPERFAMILY SSF51419 63 328 4.65E-78 T 09-03-2017 IPR029066 PLP-binding barrel TK78_RS09775 a2f01ed926a4f7ac5a4e2ee41f934a22 463 Hamap MF_02120 Diaminopimelate decarboxylase [lysA]. 52 462 39.832 T 09-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS09775 a2f01ed926a4f7ac5a4e2ee41f934a22 463 SUPERFAMILY SSF50621 302 462 4.6E-49 T 09-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 TK78_RS09775 a2f01ed926a4f7ac5a4e2ee41f934a22 463 TIGRFAM TIGR01048 lysA: diaminopimelate decarboxylase 42 461 5.5E-145 T 09-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS19285 bce5979624ea575d1e2ef00db5b217ea 344 SMART SM00418 261 330 0.0019 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS19285 bce5979624ea575d1e2ef00db5b217ea 344 Pfam PF12840 Helix-turn-helix domain 271 310 3.6E-7 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS19285 bce5979624ea575d1e2ef00db5b217ea 344 SUPERFAMILY SSF46785 268 325 1.36E-10 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS19285 bce5979624ea575d1e2ef00db5b217ea 344 Gene3D G3DSA:1.10.10.10 269 326 1.9E-12 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS08435 96d29ee53942ecc775eb09f59213790f 137 SMART SM00960 9 99 7.6E-33 T 09-03-2017 IPR004942 Roadblock/LAMTOR2 domain TK78_RS08435 96d29ee53942ecc775eb09f59213790f 137 SUPERFAMILY SSF103196 2 125 5.1E-32 T 09-03-2017 TK78_RS08435 96d29ee53942ecc775eb09f59213790f 137 Gene3D G3DSA:3.30.450.30 3 123 1.5E-25 T 09-03-2017 TK78_RS08435 96d29ee53942ecc775eb09f59213790f 137 Pfam PF03259 Roadblock/LC7 domain 9 99 2.7E-25 T 09-03-2017 IPR004942 Roadblock/LAMTOR2 domain TK78_RS18960 155efda98b1a5ebf81ef9f0c3857fafa 449 SUPERFAMILY SSF52172 16 166 1.28E-11 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS18960 155efda98b1a5ebf81ef9f0c3857fafa 449 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 220 416 1.8E-37 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS18960 155efda98b1a5ebf81ef9f0c3857fafa 449 SMART SM00448 21 149 0.0025 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS18960 155efda98b1a5ebf81ef9f0c3857fafa 449 SMART SM00331 191 416 6.9E-10 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS18960 155efda98b1a5ebf81ef9f0c3857fafa 449 Gene3D G3DSA:3.40.50.2300 13 160 4.5E-17 T 09-03-2017 TK78_RS09210 9e2e277229157612b5e55e023a3dfd2a 783 SMART SM00644 298 464 0.0087 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS09210 9e2e277229157612b5e55e023a3dfd2a 783 SUPERFAMILY SSF55846 451 476 2.16E-45 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS09210 9e2e277229157612b5e55e023a3dfd2a 783 SUPERFAMILY SSF55846 283 423 2.16E-45 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS09210 9e2e277229157612b5e55e023a3dfd2a 783 Gene3D G3DSA:3.40.80.10 277 478 1.9E-48 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS09210 9e2e277229157612b5e55e023a3dfd2a 783 Pfam PF01510 N-acetylmuramoyl-L-alanine amidase 308 464 6.8E-10 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS09210 9e2e277229157612b5e55e023a3dfd2a 783 PRINTS PR01217 Proline rich extensin signature 246 262 1.5E-10 T 09-03-2017 TK78_RS09210 9e2e277229157612b5e55e023a3dfd2a 783 PRINTS PR01217 Proline rich extensin signature 264 281 1.5E-10 T 09-03-2017 TK78_RS09210 9e2e277229157612b5e55e023a3dfd2a 783 PRINTS PR01217 Proline rich extensin signature 205 217 1.5E-10 T 09-03-2017 TK78_RS09210 9e2e277229157612b5e55e023a3dfd2a 783 PRINTS PR01217 Proline rich extensin signature 166 178 1.5E-10 T 09-03-2017 TK78_RS09210 9e2e277229157612b5e55e023a3dfd2a 783 PRINTS PR01217 Proline rich extensin signature 222 243 1.5E-10 T 09-03-2017 TK78_RS09210 9e2e277229157612b5e55e023a3dfd2a 783 SMART SM00701 283 431 6.2E-45 T 09-03-2017 IPR006619 Peptidoglycan recognition protein family domain, metazoa/bacteria GO:0008270|GO:0008745|GO:0009253 TK78_RS17710 697e20eeec92e5d2d2cb537ec8b894f5 150 Pfam PF12900 Pyridoxamine 5'-phosphate oxidase 24 144 1.7E-14 T 09-03-2017 IPR024747 Pyridoxamine 5'-phosphate oxidase-related TK78_RS17710 697e20eeec92e5d2d2cb537ec8b894f5 150 SUPERFAMILY SSF50475 19 120 3.02E-8 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS17710 697e20eeec92e5d2d2cb537ec8b894f5 150 Gene3D G3DSA:2.30.110.10 17 144 2.5E-10 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS26140 dffd8e2cf670e75bd8304b9429765a34 376 Gene3D G3DSA:1.10.3470.10 37 371 5.3E-112 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS26140 dffd8e2cf670e75bd8304b9429765a34 376 SUPERFAMILY SSF81345 37 367 1.29E-86 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS26140 dffd8e2cf670e75bd8304b9429765a34 376 Pfam PF01032 FecCD transport family 50 367 1.0E-97 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS20110 18881689641177d107a3ab5e16bff0b5 593 Gene3D G3DSA:3.40.50.620 121 469 4.4E-98 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS20110 18881689641177d107a3ab5e16bff0b5 593 PRINTS PR01038 Arginyl-tRNA synthetase signature 318 339 3.1E-23 T 09-03-2017 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19 TK78_RS20110 18881689641177d107a3ab5e16bff0b5 593 PRINTS PR01038 Arginyl-tRNA synthetase signature 122 137 3.1E-23 T 09-03-2017 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19 TK78_RS20110 18881689641177d107a3ab5e16bff0b5 593 PRINTS PR01038 Arginyl-tRNA synthetase signature 161 174 3.1E-23 T 09-03-2017 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19 TK78_RS20110 18881689641177d107a3ab5e16bff0b5 593 PRINTS PR01038 Arginyl-tRNA synthetase signature 137 153 3.1E-23 T 09-03-2017 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19 TK78_RS20110 18881689641177d107a3ab5e16bff0b5 593 Gene3D G3DSA:3.30.1360.70 9 108 5.0E-27 T 09-03-2017 IPR005148 Arginyl tRNA synthetase N-terminal domain GO:0000166|GO:0004814|GO:0005524|GO:0005737|GO:0006420 KEGG: 00970+6.1.1.19 TK78_RS20110 18881689641177d107a3ab5e16bff0b5 593 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 130 141 - T 09-03-2017 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS20110 18881689641177d107a3ab5e16bff0b5 593 SMART SM00836 477 593 1.9E-39 T 09-03-2017 IPR008909 DALR anticodon binding GO:0004814|GO:0005524|GO:0006420 TK78_RS20110 18881689641177d107a3ab5e16bff0b5 593 TIGRFAM TIGR00456 argS: arginine--tRNA ligase 15 593 2.1E-131 T 09-03-2017 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19 TK78_RS20110 18881689641177d107a3ab5e16bff0b5 593 SUPERFAMILY SSF52374 118 469 1.06E-79 T 09-03-2017 TK78_RS20110 18881689641177d107a3ab5e16bff0b5 593 Pfam PF03485 Arginyl tRNA synthetase N terminal domain 13 92 8.0E-17 T 09-03-2017 IPR005148 Arginyl tRNA synthetase N-terminal domain GO:0000166|GO:0004814|GO:0005524|GO:0005737|GO:0006420 KEGG: 00970+6.1.1.19 TK78_RS20110 18881689641177d107a3ab5e16bff0b5 593 SUPERFAMILY SSF55190 9 103 4.97E-16 T 09-03-2017 IPR005148 Arginyl tRNA synthetase N-terminal domain GO:0000166|GO:0004814|GO:0005524|GO:0005737|GO:0006420 KEGG: 00970+6.1.1.19 TK78_RS20110 18881689641177d107a3ab5e16bff0b5 593 Gene3D G3DSA:1.10.730.10 471 593 8.5E-35 T 09-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS20110 18881689641177d107a3ab5e16bff0b5 593 SUPERFAMILY SSF47323 471 593 1.7E-32 T 09-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS20110 18881689641177d107a3ab5e16bff0b5 593 Pfam PF00750 tRNA synthetases class I (R) 118 462 6.5E-100 T 09-03-2017 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19 TK78_RS20110 18881689641177d107a3ab5e16bff0b5 593 Pfam PF05746 DALR anticodon binding domain 477 593 2.0E-31 T 09-03-2017 IPR008909 DALR anticodon binding GO:0004814|GO:0005524|GO:0006420 TK78_RS20110 18881689641177d107a3ab5e16bff0b5 593 SMART SM01016 12 92 2.6E-25 T 09-03-2017 IPR005148 Arginyl tRNA synthetase N-terminal domain GO:0000166|GO:0004814|GO:0005524|GO:0005737|GO:0006420 KEGG: 00970+6.1.1.19 TK78_RS20110 18881689641177d107a3ab5e16bff0b5 593 Hamap MF_00123 Arginine--tRNA ligase [argS]. 12 593 25.709 T 09-03-2017 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19 TK78_RS01685 276ab8c9aa05f581ded39537e7ce7059 579 Pfam PF00664 ABC transporter transmembrane region 19 267 1.0E-14 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS01685 276ab8c9aa05f581ded39537e7ce7059 579 ProSitePatterns PS00211 ABC transporters family signature. 472 486 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS01685 276ab8c9aa05f581ded39537e7ce7059 579 SMART SM00382 360 546 4.0E-17 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS01685 276ab8c9aa05f581ded39537e7ce7059 579 Gene3D G3DSA:1.20.1560.10 6 310 7.2E-29 T 09-03-2017 TK78_RS01685 276ab8c9aa05f581ded39537e7ce7059 579 Pfam PF00005 ABC transporter 351 500 2.0E-31 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS01685 276ab8c9aa05f581ded39537e7ce7059 579 SUPERFAMILY SSF52540 326 568 1.54E-81 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01685 276ab8c9aa05f581ded39537e7ce7059 579 Gene3D G3DSA:3.40.50.300 333 563 7.9E-75 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01685 276ab8c9aa05f581ded39537e7ce7059 579 SUPERFAMILY SSF90123 6 298 6.15E-35 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS01685 276ab8c9aa05f581ded39537e7ce7059 579 SUPERFAMILY SSF90123 476 484 6.15E-35 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS33655 ad29b40343c16d5a2d16fc409f1c9787 451 Pfam PF13434 L-lysine 6-monooxygenase (NADPH-requiring) 12 355 6.7E-108 T 09-03-2017 IPR025700 L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase TK78_RS33655 ad29b40343c16d5a2d16fc409f1c9787 451 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 168 177 9.8E-5 T 09-03-2017 TK78_RS33655 ad29b40343c16d5a2d16fc409f1c9787 451 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 14 36 9.8E-5 T 09-03-2017 TK78_RS33655 ad29b40343c16d5a2d16fc409f1c9787 451 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 208 233 9.8E-5 T 09-03-2017 TK78_RS33655 ad29b40343c16d5a2d16fc409f1c9787 451 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 15 34 2.4E-6 T 09-03-2017 TK78_RS33655 ad29b40343c16d5a2d16fc409f1c9787 451 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 208 226 2.4E-6 T 09-03-2017 TK78_RS33655 ad29b40343c16d5a2d16fc409f1c9787 451 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 165 183 2.4E-6 T 09-03-2017 TK78_RS33655 ad29b40343c16d5a2d16fc409f1c9787 451 Gene3D G3DSA:3.50.50.60 273 337 5.3E-6 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS33655 ad29b40343c16d5a2d16fc409f1c9787 451 Gene3D G3DSA:3.50.50.60 218 240 5.3E-6 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS33655 ad29b40343c16d5a2d16fc409f1c9787 451 Gene3D G3DSA:3.40.50.720 127 217 1.1E-6 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS33655 ad29b40343c16d5a2d16fc409f1c9787 451 Gene3D G3DSA:3.40.50.720 18 64 1.1E-6 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS33655 ad29b40343c16d5a2d16fc409f1c9787 451 Gene3D G3DSA:3.50.50.60 338 429 4.6E-9 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS33655 ad29b40343c16d5a2d16fc409f1c9787 451 Gene3D G3DSA:3.50.50.60 101 126 4.6E-9 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS33655 ad29b40343c16d5a2d16fc409f1c9787 451 SUPERFAMILY SSF51905 204 243 6.22E-10 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS33655 ad29b40343c16d5a2d16fc409f1c9787 451 SUPERFAMILY SSF51905 289 402 6.22E-10 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS33655 ad29b40343c16d5a2d16fc409f1c9787 451 SUPERFAMILY SSF51905 11 246 1.64E-19 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS21455 b24e3f8d2851bc249c6a6fa8594e5e91 98 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 60 75 9.7E-8 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS21455 b24e3f8d2851bc249c6a6fa8594e5e91 98 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 6 21 9.7E-8 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS21455 b24e3f8d2851bc249c6a6fa8594e5e91 98 Gene3D G3DSA:1.10.10.10 4 89 2.0E-28 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS21455 b24e3f8d2851bc249c6a6fa8594e5e91 98 SUPERFAMILY SSF46785 3 84 1.05E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS21455 b24e3f8d2851bc249c6a6fa8594e5e91 98 Pfam PF12840 Helix-turn-helix domain 3 69 4.7E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS21455 b24e3f8d2851bc249c6a6fa8594e5e91 98 SMART SM00418 4 89 4.1E-16 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS11815 fd0aebdf2dc93eac8c69d6bebadf3fdd 1073 Pfam PF00931 NB-ARC domain 242 440 4.7E-10 T 09-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 TK78_RS11815 fd0aebdf2dc93eac8c69d6bebadf3fdd 1073 SUPERFAMILY SSF48452 939 981 5.69E-20 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS11815 fd0aebdf2dc93eac8c69d6bebadf3fdd 1073 SUPERFAMILY SSF48452 731 891 5.69E-20 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS11815 fd0aebdf2dc93eac8c69d6bebadf3fdd 1073 Gene3D G3DSA:3.40.50.300 221 377 2.3E-8 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS11815 fd0aebdf2dc93eac8c69d6bebadf3fdd 1073 SUPERFAMILY SSF48452 658 766 3.3E-13 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS11815 fd0aebdf2dc93eac8c69d6bebadf3fdd 1073 Pfam PF13424 Tetratricopeptide repeat 697 765 8.2E-10 T 09-03-2017 TK78_RS11815 fd0aebdf2dc93eac8c69d6bebadf3fdd 1073 Pfam PF13424 Tetratricopeptide repeat 774 845 1.8E-8 T 09-03-2017 TK78_RS11815 fd0aebdf2dc93eac8c69d6bebadf3fdd 1073 SUPERFAMILY SSF52540 211 477 2.88E-31 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS11815 fd0aebdf2dc93eac8c69d6bebadf3fdd 1073 SMART SM00382 243 390 7.2E-4 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS11815 fd0aebdf2dc93eac8c69d6bebadf3fdd 1073 SMART SM00028 694 727 0.068 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS11815 fd0aebdf2dc93eac8c69d6bebadf3fdd 1073 SMART SM00028 734 767 88.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS11815 fd0aebdf2dc93eac8c69d6bebadf3fdd 1073 SMART SM00028 854 887 13.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS11815 fd0aebdf2dc93eac8c69d6bebadf3fdd 1073 SMART SM00028 942 975 120.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS11815 fd0aebdf2dc93eac8c69d6bebadf3fdd 1073 SMART SM00028 814 847 2.8 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS11815 fd0aebdf2dc93eac8c69d6bebadf3fdd 1073 SMART SM00028 774 807 9.9 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS11815 fd0aebdf2dc93eac8c69d6bebadf3fdd 1073 PRINTS PR00364 Disease resistance protein signature 246 261 5.3E-9 T 09-03-2017 TK78_RS11815 fd0aebdf2dc93eac8c69d6bebadf3fdd 1073 PRINTS PR00364 Disease resistance protein signature 422 436 5.3E-9 T 09-03-2017 TK78_RS11815 fd0aebdf2dc93eac8c69d6bebadf3fdd 1073 PRINTS PR00364 Disease resistance protein signature 332 346 5.3E-9 T 09-03-2017 TK78_RS11815 fd0aebdf2dc93eac8c69d6bebadf3fdd 1073 Gene3D G3DSA:1.25.40.10 652 878 1.2E-46 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS11815 fd0aebdf2dc93eac8c69d6bebadf3fdd 1073 Gene3D G3DSA:1.25.40.10 927 979 1.2E-46 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS31385 e39e01d06a2672ea71fc462be7553d75 103 Gene3D G3DSA:3.90.960.10 3 58 5.2E-10 T 09-03-2017 IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain GO:0002161 KEGG: 00970+6.1.1.15 TK78_RS31385 e39e01d06a2672ea71fc462be7553d75 103 SUPERFAMILY SSF55826 3 58 1.57E-10 T 09-03-2017 IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain GO:0002161 KEGG: 00970+6.1.1.15 TK78_RS31385 e39e01d06a2672ea71fc462be7553d75 103 Pfam PF04073 Aminoacyl-tRNA editing domain 3 57 9.8E-7 T 09-03-2017 IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain GO:0002161 KEGG: 00970+6.1.1.15 TK78_RS01855 1644819f22812d4decdeed2393229b68 339 Gene3D G3DSA:1.10.260.40 1 50 1.5E-19 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS01855 1644819f22812d4decdeed2393229b68 339 Gene3D G3DSA:3.40.50.2300 51 177 2.7E-21 T 09-03-2017 TK78_RS01855 1644819f22812d4decdeed2393229b68 339 Pfam PF00356 Bacterial regulatory proteins, lacI family 1 45 1.3E-12 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS01855 1644819f22812d4decdeed2393229b68 339 Gene3D G3DSA:3.40.50.2300 178 308 3.6E-17 T 09-03-2017 TK78_RS01855 1644819f22812d4decdeed2393229b68 339 Pfam PF13377 Periplasmic binding protein-like domain 171 321 8.9E-15 T 09-03-2017 TK78_RS01855 1644819f22812d4decdeed2393229b68 339 SUPERFAMILY SSF53822 77 319 1.0E-24 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS01855 1644819f22812d4decdeed2393229b68 339 SMART SM00354 1 68 2.9E-9 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS01855 1644819f22812d4decdeed2393229b68 339 SUPERFAMILY SSF47413 1 52 2.06E-12 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS21550 e598afe5f3409a940e1ecfbd2292b565 335 Pfam PF03819 MazG nucleotide pyrophosphohydrolase domain 152 230 7.2E-25 T 09-03-2017 IPR004518 NTP pyrophosphohydrolase MazG, putative catalytic core TK78_RS21550 e598afe5f3409a940e1ecfbd2292b565 335 Gene3D G3DSA:1.10.287.1080 133 196 2.2E-11 T 09-03-2017 TK78_RS21550 e598afe5f3409a940e1ecfbd2292b565 335 SUPERFAMILY SSF53790 30 94 9.16E-5 T 09-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS21550 e598afe5f3409a940e1ecfbd2292b565 335 SUPERFAMILY SSF101386 133 233 9.0E-22 T 09-03-2017 TK78_RS01305 a944ec6f40ba84e8d0859e2928398824 187 SUPERFAMILY SSF52317 9 184 2.9E-42 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS01305 a944ec6f40ba84e8d0859e2928398824 187 Pfam PF01965 DJ-1/PfpI family 10 180 1.1E-43 T 09-03-2017 IPR002818 DJ-1/PfpI TK78_RS01305 a944ec6f40ba84e8d0859e2928398824 187 TIGRFAM TIGR01382 PfpI: intracellular protease, PfpI family 12 184 1.1E-42 T 09-03-2017 IPR006286 Peptidase C56, PfpI TK78_RS01305 a944ec6f40ba84e8d0859e2928398824 187 Gene3D G3DSA:3.40.50.880 6 185 2.4E-48 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS33255 94a157333d0ce4b4ad662ba770976b39 77 SUPERFAMILY SSF53822 5 39 2.98E-6 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS33255 94a157333d0ce4b4ad662ba770976b39 77 Gene3D G3DSA:3.40.50.2300 4 38 3.8E-5 T 09-03-2017 TK78_RS18125 848aee55ee48716e211c66b30ae221bd 253 SUPERFAMILY SSF55811 130 146 5.45E-7 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS18125 848aee55ee48716e211c66b30ae221bd 253 SUPERFAMILY SSF55811 38 81 5.45E-7 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS18125 848aee55ee48716e211c66b30ae221bd 253 Gene3D G3DSA:3.90.79.10 37 84 9.1E-7 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS18125 848aee55ee48716e211c66b30ae221bd 253 Gene3D G3DSA:3.90.79.10 133 206 9.1E-7 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS25245 420d6eb6db8ab9e0c0736a62ce3cd371 643 Gene3D G3DSA:3.90.980.10 117 242 5.9E-40 T 09-03-2017 IPR013264 DNA primase, catalytic core, N-terminal TK78_RS25245 420d6eb6db8ab9e0c0736a62ce3cd371 643 TIGRFAM TIGR01391 dnaG: DNA primase 5 420 2.8E-117 T 09-03-2017 IPR006295 DNA primase, DnaG GO:0003896|GO:0006269 TK78_RS25245 420d6eb6db8ab9e0c0736a62ce3cd371 643 Pfam PF10410 DnaB-helicase binding domain of primase 373 427 3.5E-12 T 09-03-2017 IPR019475 DNA primase, DnaB-helicase binding domain GO:0016779 TK78_RS25245 420d6eb6db8ab9e0c0736a62ce3cd371 643 Gene3D G3DSA:1.20.50.20 372 429 2.7E-8 T 09-03-2017 TK78_RS25245 420d6eb6db8ab9e0c0736a62ce3cd371 643 Pfam PF08275 DNA primase catalytic core, N-terminal domain 127 253 1.7E-37 T 09-03-2017 IPR013264 DNA primase, catalytic core, N-terminal TK78_RS25245 420d6eb6db8ab9e0c0736a62ce3cd371 643 PIRSF PIRSF002811 2 633 8.0E-167 T 09-03-2017 IPR030846 DNA primase DnaG, bacteria GO:0003896|GO:0006269|GO:0008270 TK78_RS25245 420d6eb6db8ab9e0c0736a62ce3cd371 643 SMART SM00766 493 622 4.2E-17 T 09-03-2017 IPR013173 DNA primase DnaG, DnaB-binding domain GO:0003896|GO:0006269 TK78_RS25245 420d6eb6db8ab9e0c0736a62ce3cd371 643 Pfam PF01807 CHC2 zinc finger 7 101 2.6E-32 T 09-03-2017 IPR002694 Zinc finger, CHC2-type GO:0003677|GO:0003896|GO:0006260|GO:0008270 TK78_RS25245 420d6eb6db8ab9e0c0736a62ce3cd371 643 SUPERFAMILY SSF57783 4 102 1.7E-31 T 09-03-2017 TK78_RS25245 420d6eb6db8ab9e0c0736a62ce3cd371 643 Pfam PF08278 DNA primase DnaG DnaB-binding 494 611 3.7E-13 T 09-03-2017 IPR013173 DNA primase DnaG, DnaB-binding domain GO:0003896|GO:0006269 TK78_RS25245 420d6eb6db8ab9e0c0736a62ce3cd371 643 Hamap MF_00974 DNA primase [dnaG]. 4 633 26.49 T 09-03-2017 IPR030846 DNA primase DnaG, bacteria GO:0003896|GO:0006269|GO:0008270 TK78_RS25245 420d6eb6db8ab9e0c0736a62ce3cd371 643 SMART SM00493 261 337 1.2E-15 T 09-03-2017 IPR006171 Toprim domain TK78_RS25245 420d6eb6db8ab9e0c0736a62ce3cd371 643 SUPERFAMILY SSF56731 117 428 4.18E-94 T 09-03-2017 TK78_RS25245 420d6eb6db8ab9e0c0736a62ce3cd371 643 Gene3D G3DSA:3.90.580.10 3 102 8.7E-36 T 09-03-2017 IPR002694 Zinc finger, CHC2-type GO:0003677|GO:0003896|GO:0006260|GO:0008270 TK78_RS25245 420d6eb6db8ab9e0c0736a62ce3cd371 643 SMART SM00400 37 91 1.1E-33 T 09-03-2017 IPR002694 Zinc finger, CHC2-type GO:0003677|GO:0003896|GO:0006260|GO:0008270 TK78_RS25245 420d6eb6db8ab9e0c0736a62ce3cd371 643 Gene3D G3DSA:3.40.1360.10 243 369 9.2E-41 T 09-03-2017 TK78_RS25245 420d6eb6db8ab9e0c0736a62ce3cd371 643 Pfam PF13662 Toprim domain 262 332 1.4E-16 T 09-03-2017 IPR006171 Toprim domain TK78_RS29980 e5941738d9b64ec985090d5b48c301a7 345 PRINTS PR00095 Anthranilate synthase component I signature 263 277 3.0E-11 T 09-03-2017 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 TK78_RS29980 e5941738d9b64ec985090d5b48c301a7 345 PRINTS PR00095 Anthranilate synthase component I signature 183 196 3.0E-11 T 09-03-2017 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 TK78_RS29980 e5941738d9b64ec985090d5b48c301a7 345 PRINTS PR00095 Anthranilate synthase component I signature 279 293 3.0E-11 T 09-03-2017 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 TK78_RS29980 e5941738d9b64ec985090d5b48c301a7 345 SUPERFAMILY SSF56322 40 333 1.7E-90 T 09-03-2017 IPR005801 ADC synthase GO:0009058 TK78_RS29980 e5941738d9b64ec985090d5b48c301a7 345 Pfam PF00425 chorismate binding enzyme 73 326 8.8E-71 T 09-03-2017 IPR015890 Chorismate-utilising enzyme, C-terminal TK78_RS29980 e5941738d9b64ec985090d5b48c301a7 345 Gene3D G3DSA:3.60.120.10 56 334 5.0E-98 T 09-03-2017 IPR005801 ADC synthase GO:0009058 TK78_RS17245 e714b59391fa0b022e94533d43af3a3e 343 Gene3D G3DSA:3.20.20.10 26 172 1.3E-13 T 09-03-2017 IPR029066 PLP-binding barrel TK78_RS17245 e714b59391fa0b022e94533d43af3a3e 343 SUPERFAMILY SSF51419 17 176 1.09E-13 T 09-03-2017 IPR029066 PLP-binding barrel TK78_RS17245 e714b59391fa0b022e94533d43af3a3e 343 Pfam PF01168 Alanine racemase, N-terminal domain 12 153 1.4E-12 T 09-03-2017 IPR001608 Alanine racemase, N-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TK78_RS24315 5f98f8781ae71c850bc2b582b7e2d569 744 Pfam PF00456 Transketolase, thiamine diphosphate binding domain 36 376 1.3E-133 T 09-03-2017 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 TK78_RS24315 5f98f8781ae71c850bc2b582b7e2d569 744 Gene3D G3DSA:3.40.50.970 37 362 3.3E-108 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS24315 5f98f8781ae71c850bc2b582b7e2d569 744 SMART SM00861 393 573 1.3E-68 T 09-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain TK78_RS24315 5f98f8781ae71c850bc2b582b7e2d569 744 Gene3D G3DSA:3.40.50.920 591 717 7.3E-46 T 09-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 TK78_RS24315 5f98f8781ae71c850bc2b582b7e2d569 744 SUPERFAMILY SSF52518 37 362 1.67E-98 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS24315 5f98f8781ae71c850bc2b582b7e2d569 744 ProSitePatterns PS00802 Transketolase signature 2. 515 531 - T 09-03-2017 IPR020826 Transketolase binding site KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 TK78_RS24315 5f98f8781ae71c850bc2b582b7e2d569 744 Gene3D G3DSA:3.40.50.970 373 578 5.6E-75 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS24315 5f98f8781ae71c850bc2b582b7e2d569 744 Pfam PF02780 Transketolase, C-terminal domain 602 709 2.2E-13 T 09-03-2017 IPR033248 Transketolase, C-terminal domain TK78_RS24315 5f98f8781ae71c850bc2b582b7e2d569 744 Pfam PF02779 Transketolase, pyrimidine binding domain 392 572 9.4E-45 T 09-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain TK78_RS24315 5f98f8781ae71c850bc2b582b7e2d569 744 SUPERFAMILY SSF52518 383 575 1.03E-66 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS24315 5f98f8781ae71c850bc2b582b7e2d569 744 SUPERFAMILY SSF52922 585 717 2.36E-38 T 09-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 TK78_RS24315 5f98f8781ae71c850bc2b582b7e2d569 744 TIGRFAM TIGR00232 tktlase_bact: transketolase 38 714 5.0E-229 T 09-03-2017 IPR005478 Transketolase, bacterial-like GO:0004802 KEGG: 00030+2.2.1.1|KEGG: 00710+2.2.1.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723|MetaCyc: PWY-6901 TK78_RS32715 880ab267cb4641e6255f3b129502c128 261 Pfam PF01012 Electron transfer flavoprotein domain 25 209 1.4E-45 T 09-03-2017 IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal Reactome: R-HSA-611105 TK78_RS32715 880ab267cb4641e6255f3b129502c128 261 SUPERFAMILY SSF52402 3 257 1.07E-71 T 09-03-2017 TK78_RS32715 880ab267cb4641e6255f3b129502c128 261 PIRSF PIRSF000090 3 261 6.2E-84 T 09-03-2017 IPR012255 Electron transfer flavoprotein, beta subunit GO:0009055 Reactome: R-HSA-611105 TK78_RS32715 880ab267cb4641e6255f3b129502c128 261 Gene3D G3DSA:3.40.50.620 3 260 5.0E-85 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS32715 880ab267cb4641e6255f3b129502c128 261 SMART SM00893 24 214 4.8E-58 T 09-03-2017 IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal Reactome: R-HSA-611105 TK78_RS12870 cd939c5b4bd4bab5eaadb3b03d6c2c2b 482 Hamap MF_01966 NAD(P)H-hydrate epimerase [nnrE]. 5 205 20.246 T 09-03-2017 IPR004443 YjeF N-terminal domain MetaCyc: PWY-6938 TK78_RS12870 cd939c5b4bd4bab5eaadb3b03d6c2c2b 482 Pfam PF01256 Carbohydrate kinase 241 459 1.2E-52 T 09-03-2017 IPR000631 ATP-dependent (S)-NAD(P)H-hydrate dehydratase GO:0052855 Reactome: R-HSA-197264 TK78_RS12870 cd939c5b4bd4bab5eaadb3b03d6c2c2b 482 Pfam PF03853 YjeF-related protein N-terminus 25 184 1.1E-39 T 09-03-2017 IPR004443 YjeF N-terminal domain MetaCyc: PWY-6938 TK78_RS12870 cd939c5b4bd4bab5eaadb3b03d6c2c2b 482 TIGRFAM TIGR00196 yjeF_cterm: YjeF family C-terminal domain 224 476 6.7E-50 T 09-03-2017 IPR000631 ATP-dependent (S)-NAD(P)H-hydrate dehydratase GO:0052855 Reactome: R-HSA-197264 TK78_RS12870 cd939c5b4bd4bab5eaadb3b03d6c2c2b 482 TIGRFAM TIGR00197 yjeF_nterm: YjeF family N-terminal domain 13 204 2.0E-30 T 09-03-2017 IPR004443 YjeF N-terminal domain MetaCyc: PWY-6938 TK78_RS12870 cd939c5b4bd4bab5eaadb3b03d6c2c2b 482 Gene3D G3DSA:3.40.1190.20 225 478 5.3E-81 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS12870 cd939c5b4bd4bab5eaadb3b03d6c2c2b 482 PIRSF PIRSF017184 1 480 9.1E-104 T 09-03-2017 IPR030677 Bifunctional NAD(P)H-hydrate repair enzyme Nnr GO:0052855 MetaCyc: PWY-6938 TK78_RS12870 cd939c5b4bd4bab5eaadb3b03d6c2c2b 482 Hamap MF_01965 ADP-dependent (S)-NAD(P)H-hydrate dehydratase [nnrD]. 218 481 20.488 T 09-03-2017 IPR000631 ATP-dependent (S)-NAD(P)H-hydrate dehydratase GO:0052855 Reactome: R-HSA-197264 TK78_RS12870 cd939c5b4bd4bab5eaadb3b03d6c2c2b 482 SUPERFAMILY SSF53613 218 478 1.64E-58 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS12870 cd939c5b4bd4bab5eaadb3b03d6c2c2b 482 SUPERFAMILY SSF64153 4 239 8.76E-49 T 09-03-2017 IPR004443 YjeF N-terminal domain MetaCyc: PWY-6938 TK78_RS12870 cd939c5b4bd4bab5eaadb3b03d6c2c2b 482 Gene3D G3DSA:3.40.50.10260 2 224 2.1E-59 T 09-03-2017 IPR004443 YjeF N-terminal domain MetaCyc: PWY-6938 TK78_RS06270 8679c5adcd631c8e1d893ae52068c063 790 Pfam PF07679 Immunoglobulin I-set domain 536 621 2.5E-6 T 09-03-2017 IPR013098 Immunoglobulin I-set TK78_RS06270 8679c5adcd631c8e1d893ae52068c063 790 SUPERFAMILY SSF50969 318 525 2.2E-12 T 09-03-2017 IPR011044 Quinoprotein amine dehydrogenase, beta chain-like TK78_RS06270 8679c5adcd631c8e1d893ae52068c063 790 SUPERFAMILY SSF50969 213 267 2.2E-12 T 09-03-2017 IPR011044 Quinoprotein amine dehydrogenase, beta chain-like TK78_RS06270 8679c5adcd631c8e1d893ae52068c063 790 Gene3D G3DSA:2.60.40.230 59 187 3.2E-19 T 09-03-2017 IPR027273 Neocarzinostatin-like TK78_RS06270 8679c5adcd631c8e1d893ae52068c063 790 SUPERFAMILY SSF48726 533 623 7.93E-10 T 09-03-2017 IPR007110 Immunoglobulin-like domain GO:0005515 TK78_RS06270 8679c5adcd631c8e1d893ae52068c063 790 SUPERFAMILY SSF49319 59 187 1.9E-11 T 09-03-2017 IPR027273 Neocarzinostatin-like TK78_RS06270 8679c5adcd631c8e1d893ae52068c063 790 Gene3D G3DSA:2.130.10.10 331 429 4.9E-5 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS06270 8679c5adcd631c8e1d893ae52068c063 790 Gene3D G3DSA:2.130.10.10 462 521 4.9E-5 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS06270 8679c5adcd631c8e1d893ae52068c063 790 Gene3D G3DSA:2.60.40.10 530 624 1.1E-10 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS16925 addf8331871219fa1c04e6f4a19b22f8 275 SUPERFAMILY SSF51695 13 270 2.62E-66 T 09-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 TK78_RS16925 addf8331871219fa1c04e6f4a19b22f8 275 Gene3D G3DSA:3.20.20.190 6 272 7.7E-77 T 09-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 TK78_RS16925 addf8331871219fa1c04e6f4a19b22f8 275 Pfam PF03009 Glycerophosphoryl diester phosphodiesterase family 18 266 1.9E-44 T 09-03-2017 IPR030395 Glycerophosphodiester phosphodiesterase domain GO:0006629|GO:0008081 TK78_RS23185 e1485d3895229e9dfe309681d0cd2be0 485 Pfam PF00672 HAMP domain 161 228 2.1E-11 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS23185 e1485d3895229e9dfe309681d0cd2be0 485 SUPERFAMILY SSF55874 303 445 2.23E-21 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS23185 e1485d3895229e9dfe309681d0cd2be0 485 SMART SM00304 180 232 3.6E-10 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS23185 e1485d3895229e9dfe309681d0cd2be0 485 SMART SM00388 233 291 8.3E-7 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS23185 e1485d3895229e9dfe309681d0cd2be0 485 Pfam PF00512 His Kinase A (phospho-acceptor) domain 235 282 9.5E-8 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS23185 e1485d3895229e9dfe309681d0cd2be0 485 PRINTS PR00344 Bacterial sensor protein C-terminal signature 409 427 3.9E-7 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS23185 e1485d3895229e9dfe309681d0cd2be0 485 PRINTS PR00344 Bacterial sensor protein C-terminal signature 376 390 3.9E-7 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS23185 e1485d3895229e9dfe309681d0cd2be0 485 Gene3D G3DSA:1.10.287.130 223 283 2.8E-9 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS23185 e1485d3895229e9dfe309681d0cd2be0 485 SUPERFAMILY SSF158472 181 229 6.41E-5 T 09-03-2017 TK78_RS23185 e1485d3895229e9dfe309681d0cd2be0 485 Gene3D G3DSA:3.30.565.10 302 448 1.3E-20 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS23185 e1485d3895229e9dfe309681d0cd2be0 485 SMART SM00387 339 449 2.1E-12 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS23185 e1485d3895229e9dfe309681d0cd2be0 485 SUPERFAMILY SSF47384 217 285 6.08E-9 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS23185 e1485d3895229e9dfe309681d0cd2be0 485 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 344 445 2.4E-10 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS15750 5529ae8f726d6afa91392459dec74038 177 Pfam PF04978 Protein of unknown function (DUF664) 21 170 9.2E-36 T 09-03-2017 IPR007061 Protein of unknown function DUF664 TK78_RS15750 5529ae8f726d6afa91392459dec74038 177 Gene3D G3DSA:1.20.120.450 9 171 3.3E-28 T 09-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase TK78_RS15750 5529ae8f726d6afa91392459dec74038 177 SUPERFAMILY SSF109854 16 169 9.62E-33 T 09-03-2017 TK78_RS20490 d044c585479d0745a8647a6561351dae 941 Gene3D G3DSA:2.30.120.10 268 324 2.2E-10 T 09-03-2017 TK78_RS20490 d044c585479d0745a8647a6561351dae 941 SUPERFAMILY SSF55729 767 933 2.34E-38 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS20490 d044c585479d0745a8647a6561351dae 941 SUPERFAMILY SSF56235 24 728 1.67E-146 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS20490 d044c585479d0745a8647a6561351dae 941 Gene3D G3DSA:3.40.630.30 768 934 1.3E-49 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS20490 d044c585479d0745a8647a6561351dae 941 Gene3D G3DSA:3.60.20.10 147 267 7.0E-81 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS20490 d044c585479d0745a8647a6561351dae 941 Gene3D G3DSA:3.60.20.10 352 531 7.0E-81 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS20490 d044c585479d0745a8647a6561351dae 941 Pfam PF01804 Penicillin amidase 25 718 5.7E-177 T 09-03-2017 IPR002692 Penicillin/cephalosporin acylase GO:0016787|GO:0017000 TK78_RS20490 d044c585479d0745a8647a6561351dae 941 SMART SM01006 772 820 5.1E-12 T 09-03-2017 IPR019432 Siderophore biosynthesis protein, conserved domain TK78_RS20490 d044c585479d0745a8647a6561351dae 941 Pfam PF13523 Acetyltransferase (GNAT) domain 775 920 7.8E-50 T 09-03-2017 TK78_RS20490 d044c585479d0745a8647a6561351dae 941 Gene3D G3DSA:1.10.439.10 24 146 1.0E-34 T 09-03-2017 IPR023343 Penicillin amidase type, domain1 GO:0016811 TK78_RS28810 05170f37b536575a421aba5ff9b64b19 613 Gene3D G3DSA:3.50.50.60 522 599 2.7E-7 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS28810 05170f37b536575a421aba5ff9b64b19 613 Gene3D G3DSA:3.50.50.60 123 191 2.7E-7 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS28810 05170f37b536575a421aba5ff9b64b19 613 Gene3D G3DSA:3.50.50.60 5 61 2.7E-7 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS28810 05170f37b536575a421aba5ff9b64b19 613 Pfam PF13454 FAD-NAD(P)-binding 8 188 5.3E-41 T 09-03-2017 TK78_RS28810 05170f37b536575a421aba5ff9b64b19 613 SUPERFAMILY SSF51905 95 223 2.85E-7 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS28810 05170f37b536575a421aba5ff9b64b19 613 SUPERFAMILY SSF51905 1 66 2.85E-7 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS17570 d1f04baf5cf3ccd4be2bc2891f9d494b 114 Pfam PF00581 Rhodanese-like domain 20 97 9.6E-12 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS17570 d1f04baf5cf3ccd4be2bc2891f9d494b 114 SMART SM00450 4 102 5.6E-17 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS17570 d1f04baf5cf3ccd4be2bc2891f9d494b 114 Gene3D G3DSA:3.40.250.10 17 107 7.0E-26 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS17570 d1f04baf5cf3ccd4be2bc2891f9d494b 114 SUPERFAMILY SSF52821 16 107 9.95E-28 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS01355 697f1320faf7b0715fd80b6437460b92 350 SUPERFAMILY SSF53901 6 350 1.99E-51 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS01355 697f1320faf7b0715fd80b6437460b92 350 Gene3D G3DSA:3.40.47.10 208 350 3.7E-40 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS01355 697f1320faf7b0715fd80b6437460b92 350 PIRSF PIRSF000451 1 350 7.1E-121 T 09-03-2017 IPR011141 Polyketide synthase, type III GO:0009058|GO:0016747 TK78_RS01355 697f1320faf7b0715fd80b6437460b92 350 Pfam PF00195 Chalcone and stilbene synthases, N-terminal domain 4 197 3.3E-19 T 09-03-2017 IPR001099 Chalcone/stilbene synthase, N-terminal TK78_RS01355 697f1320faf7b0715fd80b6437460b92 350 Gene3D G3DSA:3.40.47.10 2 198 5.5E-50 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS01355 697f1320faf7b0715fd80b6437460b92 350 Pfam PF02797 Chalcone and stilbene synthases, C-terminal domain 210 349 1.3E-17 T 09-03-2017 IPR012328 Chalcone/stilbene synthase, C-terminal TK78_RS14130 3ad8a2152cda40c5f9db67a267ca914f 224 SUPERFAMILY SSF53335 12 204 2.92E-34 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS14130 3ad8a2152cda40c5f9db67a267ca914f 224 Gene3D G3DSA:3.40.50.150 31 222 1.3E-36 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS14130 3ad8a2152cda40c5f9db67a267ca914f 224 Pfam PF13489 Methyltransferase domain 36 174 2.3E-15 T 09-03-2017 TK78_RS10165 a9a07d7954afdd8bd257c490b9e87c42 490 PRINTS PR01217 Proline rich extensin signature 332 344 3.4E-15 T 09-03-2017 TK78_RS10165 a9a07d7954afdd8bd257c490b9e87c42 490 PRINTS PR01217 Proline rich extensin signature 372 384 3.4E-15 T 09-03-2017 TK78_RS10165 a9a07d7954afdd8bd257c490b9e87c42 490 PRINTS PR01217 Proline rich extensin signature 384 405 3.4E-15 T 09-03-2017 TK78_RS10165 a9a07d7954afdd8bd257c490b9e87c42 490 PRINTS PR01217 Proline rich extensin signature 351 367 3.4E-15 T 09-03-2017 TK78_RS10165 a9a07d7954afdd8bd257c490b9e87c42 490 TIGRFAM TIGR04215 choice_anch_A: choice-of-anchor A domain 50 331 1.7E-55 T 09-03-2017 IPR026588 Choice-of-anchor A domain TK78_RS25260 6e98d8be197406ca2fe156a39031cf42 577 SUPERFAMILY SSF90123 6 314 2.22E-71 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS25260 6e98d8be197406ca2fe156a39031cf42 577 ProSitePatterns PS00211 ABC transporters family signature. 472 486 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS25260 6e98d8be197406ca2fe156a39031cf42 577 Pfam PF00664 ABC transporter transmembrane region 18 288 1.1E-43 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS25260 6e98d8be197406ca2fe156a39031cf42 577 SUPERFAMILY SSF52540 330 570 1.19E-80 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS25260 6e98d8be197406ca2fe156a39031cf42 577 Pfam PF00005 ABC transporter 351 498 2.3E-26 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS25260 6e98d8be197406ca2fe156a39031cf42 577 Gene3D G3DSA:1.20.1560.10 6 314 1.8E-63 T 09-03-2017 TK78_RS25260 6e98d8be197406ca2fe156a39031cf42 577 Gene3D G3DSA:3.40.50.300 333 564 7.3E-72 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS25260 6e98d8be197406ca2fe156a39031cf42 577 SMART SM00382 360 546 9.8E-13 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS13335 ceb5f45599595d2de5b05357011bbf5e 218 SUPERFAMILY SSF51735 1 205 1.1E-37 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS13335 ceb5f45599595d2de5b05357011bbf5e 218 Gene3D G3DSA:3.40.50.720 1 206 1.8E-42 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS13335 ceb5f45599595d2de5b05357011bbf5e 218 Pfam PF13460 NAD(P)H-binding 7 192 6.1E-42 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS29935 4e542fe1d569db49a92e7c734c30e4b0 467 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 23 45 - T 09-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 TK78_RS29935 4e542fe1d569db49a92e7c734c30e4b0 467 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 135 147 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS29935 4e542fe1d569db49a92e7c734c30e4b0 467 SUPERFAMILY SSF56112 13 263 2.43E-61 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS29935 4e542fe1d569db49a92e7c734c30e4b0 467 Pfam PF00069 Protein kinase domain 18 261 2.0E-40 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS29935 4e542fe1d569db49a92e7c734c30e4b0 467 Gene3D G3DSA:3.30.200.20 9 93 8.3E-17 T 09-03-2017 TK78_RS29935 4e542fe1d569db49a92e7c734c30e4b0 467 Gene3D G3DSA:1.10.510.10 100 328 1.9E-40 T 09-03-2017 TK78_RS29935 4e542fe1d569db49a92e7c734c30e4b0 467 SMART SM00220 17 269 1.0E-46 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS20525 03264bb4c98c7e7861ef81d3bd58f54b 336 Gene3D G3DSA:2.120.10.30 25 304 1.0E-70 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS20525 03264bb4c98c7e7861ef81d3bd58f54b 336 SUPERFAMILY SSF63829 25 302 1.35E-63 T 09-03-2017 TK78_RS20525 03264bb4c98c7e7861ef81d3bd58f54b 336 Pfam PF08450 SMP-30/Gluconolaconase/LRE-like region 37 289 1.6E-58 T 09-03-2017 IPR013658 SMP-30/Gluconolactonase/LRE-like region TK78_RS20525 03264bb4c98c7e7861ef81d3bd58f54b 336 PRINTS PR01790 Senescence marker protein-30 (SMP30) family signature 169 191 1.3E-9 T 09-03-2017 IPR005511 Senescence marker protein-30 (SMP-30) TK78_RS20525 03264bb4c98c7e7861ef81d3bd58f54b 336 PRINTS PR01790 Senescence marker protein-30 (SMP30) family signature 232 249 1.3E-9 T 09-03-2017 IPR005511 Senescence marker protein-30 (SMP-30) TK78_RS20525 03264bb4c98c7e7861ef81d3bd58f54b 336 PRINTS PR01790 Senescence marker protein-30 (SMP30) family signature 38 55 1.3E-9 T 09-03-2017 IPR005511 Senescence marker protein-30 (SMP-30) TK78_RS20525 03264bb4c98c7e7861ef81d3bd58f54b 336 PRINTS PR01790 Senescence marker protein-30 (SMP30) family signature 272 290 1.3E-9 T 09-03-2017 IPR005511 Senescence marker protein-30 (SMP-30) TK78_RS20525 03264bb4c98c7e7861ef81d3bd58f54b 336 PRINTS PR01790 Senescence marker protein-30 (SMP30) family signature 192 212 1.3E-9 T 09-03-2017 IPR005511 Senescence marker protein-30 (SMP-30) TK78_RS17125 d6537f3085d29abc55211bd755292513 247 Pfam PF01614 Bacterial transcriptional regulator 130 219 4.4E-15 T 09-03-2017 IPR014757 Transcription regulator IclR, C-terminal TK78_RS17125 d6537f3085d29abc55211bd755292513 247 SUPERFAMILY SSF55781 77 234 1.18E-22 T 09-03-2017 IPR029016 GAF domain-like TK78_RS17125 d6537f3085d29abc55211bd755292513 247 SUPERFAMILY SSF46785 2 61 5.73E-12 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS17125 d6537f3085d29abc55211bd755292513 247 Gene3D G3DSA:3.30.450.40 83 239 1.1E-25 T 09-03-2017 IPR029016 GAF domain-like TK78_RS17125 d6537f3085d29abc55211bd755292513 247 Gene3D G3DSA:1.10.10.10 2 62 1.8E-16 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS17125 d6537f3085d29abc55211bd755292513 247 Pfam PF09339 IclR helix-turn-helix domain 4 54 1.7E-15 T 09-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 TK78_RS17125 d6537f3085d29abc55211bd755292513 247 SMART SM00346 2 91 8.3E-5 T 09-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 TK78_RS04285 fa268f7efc7727a20fb5116ae64cf2bd 265 ProSitePatterns PS00211 ABC transporters family signature. 142 156 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS04285 fa268f7efc7727a20fb5116ae64cf2bd 265 SMART SM00382 28 217 1.6E-6 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS04285 fa268f7efc7727a20fb5116ae64cf2bd 265 Gene3D G3DSA:3.40.50.300 3 236 6.5E-51 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS04285 fa268f7efc7727a20fb5116ae64cf2bd 265 SUPERFAMILY SSF52540 3 239 1.41E-49 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS04285 fa268f7efc7727a20fb5116ae64cf2bd 265 Pfam PF00005 ABC transporter 19 169 1.1E-22 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS03915 2cfe07fa133ff7626734f8b1fe13364c 290 SUPERFAMILY SSF51658 3 279 6.81E-61 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS03915 2cfe07fa133ff7626734f8b1fe13364c 290 Gene3D G3DSA:3.20.20.150 4 279 5.8E-61 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS03915 2cfe07fa133ff7626734f8b1fe13364c 290 Pfam PF01261 Xylose isomerase-like TIM barrel 23 234 7.0E-35 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Pfam PF00550 Phosphopantetheine attachment site 3154 3215 1.4E-13 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Pfam PF00550 Phosphopantetheine attachment site 981 1040 5.2E-13 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Pfam PF00550 Phosphopantetheine attachment site 2072 2131 1.9E-14 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Pfam PF00550 Phosphopantetheine attachment site 6032 6095 4.0E-16 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Pfam PF00550 Phosphopantetheine attachment site 3821 3882 1.2E-11 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Pfam PF00550 Phosphopantetheine attachment site 4921 4982 3.0E-13 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Pfam PF00668 Condensation domain 10 302 1.7E-43 T 09-03-2017 IPR001242 Condensation domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Pfam PF00668 Condensation domain 2183 2475 3.3E-34 T 09-03-2017 IPR001242 Condensation domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Pfam PF00668 Condensation domain 5034 5328 1.6E-40 T 09-03-2017 IPR001242 Condensation domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Pfam PF00668 Condensation domain 3934 4226 5.6E-34 T 09-03-2017 IPR001242 Condensation domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Pfam PF00668 Condensation domain 1092 1385 1.1E-35 T 09-03-2017 IPR001242 Condensation domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Pfam PF00668 Condensation domain 3234 3533 2.4E-61 T 09-03-2017 IPR001242 Condensation domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:3.40.50.980 5656 5822 3.9E-47 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:3.40.50.980 4553 4710 3.9E-46 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:3.40.50.980 1705 1862 3.9E-46 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SUPERFAMILY SSF56801 1516 2082 4.58E-159 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SUPERFAMILY SSF56801 2602 3164 9.94E-170 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3842 3857 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SUPERFAMILY SSF47336 4911 4982 1.2E-18 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SUPERFAMILY SSF47336 3813 3882 5.63E-17 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 ProSitePatterns PS00455 Putative AMP-binding domain signature. 5646 5657 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SUPERFAMILY SSF52777 13 185 3.22E-33 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SUPERFAMILY SSF47336 2062 2131 3.8E-18 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:3.30.300.30 1955 2057 2.5E-39 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SUPERFAMILY SSF52777 5032 5229 2.56E-33 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SUPERFAMILY SSF47336 6023 6095 2.49E-21 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SUPERFAMILY SSF52777 2363 2626 5.0E-41 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Pfam PF00501 AMP-binding enzyme 1550 1961 2.6E-100 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Pfam PF00501 AMP-binding enzyme 465 866 2.1E-95 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Pfam PF00501 AMP-binding enzyme 5496 5911 5.0E-102 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Pfam PF00501 AMP-binding enzyme 3707 3788 4.4E-13 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Pfam PF00501 AMP-binding enzyme 4397 4809 5.5E-101 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Pfam PF00501 AMP-binding enzyme 2640 3042 5.6E-105 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 ProSitePatterns PS00455 Putative AMP-binding domain signature. 2786 2797 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SUPERFAMILY SSF56801 3685 3788 2.22E-18 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SUPERFAMILY SSF52777 4114 4359 1.56E-38 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SMART SM00823 Phosphopantetheine attachment site 6030 6099 6.8E-11 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SMART SM00823 Phosphopantetheine attachment site 3151 3220 1.1E-4 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SMART SM00823 Phosphopantetheine attachment site 4918 4986 5.5E-4 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SMART SM00823 Phosphopantetheine attachment site 978 1046 9.0E-4 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SMART SM00823 Phosphopantetheine attachment site 3821 3886 0.0025 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SMART SM00823 Phosphopantetheine attachment site 2069 2137 4.7E-5 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Pfam PF13193 AMP-binding enzyme C-terminal domain 874 953 1.9E-13 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Pfam PF13193 AMP-binding enzyme C-terminal domain 1969 2045 2.3E-13 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Pfam PF13193 AMP-binding enzyme C-terminal domain 3050 3126 2.5E-11 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Pfam PF13193 AMP-binding enzyme C-terminal domain 4817 4893 2.0E-13 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Pfam PF13193 AMP-binding enzyme C-terminal domain 5919 6005 3.2E-13 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SUPERFAMILY SSF56801 4363 4931 1.15E-161 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SUPERFAMILY SSF52777 191 453 1.67E-40 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:3.40.50.980 2808 2953 3.3E-47 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:3.40.50.980 637 778 1.6E-27 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 ProSitePatterns PS00012 Phosphopantetheine attachment site. 6054 6069 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 ProSitePatterns PS00455 Putative AMP-binding domain signature. 4544 4555 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SUPERFAMILY SSF56801 426 991 1.57E-151 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:1.10.1200.10 983 1042 5.3E-24 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:1.10.1200.10 2062 2133 9.8E-25 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:1.10.1200.10 3156 3221 4.3E-25 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:1.10.1200.10 4923 4984 8.9E-26 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:1.10.1200.10 3809 3887 3.4E-22 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:1.10.1200.10 6035 6100 3.3E-29 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:2.30.38.10 5823 5901 3.9E-25 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:2.30.38.10 2954 3032 1.3E-27 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:2.30.38.10 4720 4799 2.5E-23 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:2.30.38.10 3716 3786 9.3E-18 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:2.30.38.10 1872 1951 2.2E-23 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:2.30.38.10 779 856 1.8E-27 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 ProSitePatterns PS00455 Putative AMP-binding domain signature. 615 626 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SUPERFAMILY SSF52777 1090 1286 1.89E-34 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SUPERFAMILY SSF56801 5462 6043 3.66E-166 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:3.30.300.30 861 982 4.2E-40 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:3.30.300.30 3037 3155 5.8E-39 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:3.30.300.30 4804 4922 1.9E-41 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:3.30.300.30 5906 6034 5.6E-43 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SUPERFAMILY SSF52777 3422 3668 1.89E-56 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SUPERFAMILY SSF52777 2181 2376 4.45E-33 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:3.40.50.980 459 636 8.2E-52 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:3.40.50.980 1544 1704 2.7E-51 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:3.40.50.980 4391 4552 6.2E-52 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:3.40.50.980 2634 2807 1.9E-52 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Gene3D G3DSA:3.40.50.980 5490 5655 1.4E-50 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3175 3190 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 4418 4833 3.1E-137 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 1571 1985 1.2E-138 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 2660 3066 9.2E-144 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 5517 5935 1.7E-140 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 486 890 4.4E-132 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SUPERFAMILY SSF52777 3237 3409 2.45E-47 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SUPERFAMILY SSF47336 3145 3217 4.58E-19 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 ProSitePatterns PS00455 Putative AMP-binding domain signature. 1696 1707 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SUPERFAMILY SSF52777 1273 1512 8.56E-40 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 Pfam PF13745 HxxPF-repeated domain 3556 3650 1.7E-26 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SUPERFAMILY SSF52777 3932 4127 6.67E-33 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SUPERFAMILY SSF52777 5216 5484 1.89E-41 T 09-03-2017 TK78_RS29770 1a26edc2f6dbf7e6e98e24503cf71eb3 6119 SUPERFAMILY SSF47336 971 1040 1.1E-17 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS14930 9e7d0c3a3b63793e7c0abf786b48cdae 154 Gene3D G3DSA:1.10.10.10 9 151 4.6E-32 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS14930 9e7d0c3a3b63793e7c0abf786b48cdae 154 SMART SM00347 37 140 1.4E-12 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS14930 9e7d0c3a3b63793e7c0abf786b48cdae 154 Pfam PF12802 MarR family 42 103 6.0E-9 T 09-03-2017 TK78_RS14930 9e7d0c3a3b63793e7c0abf786b48cdae 154 SUPERFAMILY SSF46785 12 151 9.1E-27 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS02450 e1e58310adbf4e4c8678a8d569294aba 297 SUPERFAMILY SSF161098 25 297 2.06E-69 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS02450 e1e58310adbf4e4c8678a8d569294aba 297 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 102 291 6.8E-21 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS02450 e1e58310adbf4e4c8678a8d569294aba 297 Gene3D G3DSA:1.10.3720.10 26 285 1.1E-65 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS07875 781a5ca9435c9dadce89dc79ac26522b 436 Pfam PF02163 Peptidase family M50 16 389 1.1E-43 T 09-03-2017 IPR008915 Peptidase M50 GO:0004222|GO:0006508 Reactome: R-HSA-1655829|Reactome: R-HSA-381033 TK78_RS07875 781a5ca9435c9dadce89dc79ac26522b 436 Gene3D G3DSA:2.30.42.10 125 242 1.5E-20 T 09-03-2017 IPR001478 PDZ domain GO:0005515 TK78_RS07875 781a5ca9435c9dadce89dc79ac26522b 436 SUPERFAMILY SSF50156 131 240 1.31E-14 T 09-03-2017 IPR001478 PDZ domain GO:0005515 TK78_RS07875 781a5ca9435c9dadce89dc79ac26522b 436 SMART SM00228 152 233 0.003 T 09-03-2017 IPR001478 PDZ domain GO:0005515 TK78_RS21995 893af5c276ed121169a6e23509de1157 455 Gene3D G3DSA:3.40.120.10 10 132 5.0E-26 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS21995 893af5c276ed121169a6e23509de1157 455 Pfam PF02880 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III 266 372 4.9E-27 T 09-03-2017 IPR005846 Alpha-D-phosphohexomutase, alpha/beta/alpha domain III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS21995 893af5c276ed121169a6e23509de1157 455 Pfam PF02878 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I 7 135 1.2E-29 T 09-03-2017 IPR005844 Alpha-D-phosphohexomutase, alpha/beta/alpha domain I GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS21995 893af5c276ed121169a6e23509de1157 455 SUPERFAMILY SSF55957 375 454 2.27E-18 T 09-03-2017 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS21995 893af5c276ed121169a6e23509de1157 455 Pfam PF00408 Phosphoglucomutase/phosphomannomutase, C-terminal domain 377 454 3.9E-12 T 09-03-2017 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS21995 893af5c276ed121169a6e23509de1157 455 Gene3D G3DSA:3.30.310.50 375 454 9.9E-22 T 09-03-2017 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS21995 893af5c276ed121169a6e23509de1157 455 SUPERFAMILY SSF53738 8 169 3.77E-30 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS21995 893af5c276ed121169a6e23509de1157 455 Gene3D G3DSA:3.40.120.10 176 253 7.0E-31 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS21995 893af5c276ed121169a6e23509de1157 455 SUPERFAMILY SSF53738 264 369 6.67E-30 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS21995 893af5c276ed121169a6e23509de1157 455 SUPERFAMILY SSF53738 157 258 2.86E-29 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS21995 893af5c276ed121169a6e23509de1157 455 Gene3D G3DSA:3.40.120.10 254 372 5.9E-36 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS21995 893af5c276ed121169a6e23509de1157 455 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 208 221 2.2E-21 T 09-03-2017 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS21995 893af5c276ed121169a6e23509de1157 455 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 174 193 2.2E-21 T 09-03-2017 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS21995 893af5c276ed121169a6e23509de1157 455 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 92 106 2.2E-21 T 09-03-2017 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS21995 893af5c276ed121169a6e23509de1157 455 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 237 252 2.2E-21 T 09-03-2017 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS21995 893af5c276ed121169a6e23509de1157 455 Pfam PF02879 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II 158 257 6.3E-25 T 09-03-2017 IPR005845 Alpha-D-phosphohexomutase, alpha/beta/alpha domain II GO:0005975 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS24010 3293ddb31f7de098d7339096bf6ee021 291 Gene3D G3DSA:3.40.80.10 23 193 2.0E-16 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS24010 3293ddb31f7de098d7339096bf6ee021 291 SUPERFAMILY SSF55846 18 195 1.01E-22 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS24010 3293ddb31f7de098d7339096bf6ee021 291 Pfam PF01510 N-acetylmuramoyl-L-alanine amidase 40 179 2.2E-15 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS24010 3293ddb31f7de098d7339096bf6ee021 291 SMART SM00644 27 180 3.5E-21 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS26390 9acfcef90d52d7f4ee56f1c7a7712854 1772 Pfam PF02922 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) 1044 1122 1.7E-8 T 09-03-2017 IPR004193 Glycoside hydrolase, family 13, N-terminal GO:0004553|GO:0005975 Reactome: R-HSA-3322077|Reactome: R-HSA-3878781 TK78_RS26390 9acfcef90d52d7f4ee56f1c7a7712854 1772 SUPERFAMILY SSF51445 48 184 9.64E-94 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS26390 9acfcef90d52d7f4ee56f1c7a7712854 1772 SUPERFAMILY SSF51445 224 520 9.64E-94 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS26390 9acfcef90d52d7f4ee56f1c7a7712854 1772 SUPERFAMILY SSF49452 711 801 2.0E-17 T 09-03-2017 IPR013784 Carbohydrate-binding-like fold GO:0030246 TK78_RS26390 9acfcef90d52d7f4ee56f1c7a7712854 1772 Gene3D G3DSA:3.20.20.80 83 522 2.7E-98 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS26390 9acfcef90d52d7f4ee56f1c7a7712854 1772 SMART SM00642 58 511 1.2E-95 T 09-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 TK78_RS26390 9acfcef90d52d7f4ee56f1c7a7712854 1772 SUPERFAMILY SSF49452 780 904 2.62E-30 T 09-03-2017 IPR013784 Carbohydrate-binding-like fold GO:0030246 TK78_RS26390 9acfcef90d52d7f4ee56f1c7a7712854 1772 Pfam PF11852 Domain of unknown function (DUF3372) 1620 1770 1.2E-39 T 09-03-2017 IPR024561 Alpha-1,6-glucosidases, pullulanase-type, C-terminal TK78_RS26390 9acfcef90d52d7f4ee56f1c7a7712854 1772 Pfam PF03714 Bacterial pullanase-associated domain 718 796 2.6E-9 T 09-03-2017 IPR005323 Bacterial pullanase-associated domain GO:0005975|GO:0030246 TK78_RS26390 9acfcef90d52d7f4ee56f1c7a7712854 1772 Pfam PF03714 Bacterial pullanase-associated domain 813 902 3.7E-18 T 09-03-2017 IPR005323 Bacterial pullanase-associated domain GO:0005975|GO:0030246 TK78_RS26390 9acfcef90d52d7f4ee56f1c7a7712854 1772 SUPERFAMILY SSF81296 1042 1139 7.6E-19 T 09-03-2017 IPR014756 Immunoglobulin E-set TK78_RS26390 9acfcef90d52d7f4ee56f1c7a7712854 1772 Gene3D G3DSA:2.60.40.1180 523 600 8.8E-9 T 09-03-2017 IPR013780 Glycosyl hydrolase, all-beta TK78_RS26390 9acfcef90d52d7f4ee56f1c7a7712854 1772 Gene3D G3DSA:3.20.20.80 1653 1679 1.7E-74 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS26390 9acfcef90d52d7f4ee56f1c7a7712854 1772 Gene3D G3DSA:3.20.20.80 1151 1452 1.7E-74 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS26390 9acfcef90d52d7f4ee56f1c7a7712854 1772 Gene3D G3DSA:3.20.20.80 1499 1616 1.7E-74 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS26390 9acfcef90d52d7f4ee56f1c7a7712854 1772 SUPERFAMILY SSF51445 1134 1678 1.59E-117 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS26390 9acfcef90d52d7f4ee56f1c7a7712854 1772 SUPERFAMILY SSF51011 1681 1771 1.87E-20 T 09-03-2017 TK78_RS26390 9acfcef90d52d7f4ee56f1c7a7712854 1772 SUPERFAMILY SSF81296 912 1034 1.82E-32 T 09-03-2017 IPR014756 Immunoglobulin E-set TK78_RS26390 9acfcef90d52d7f4ee56f1c7a7712854 1772 Pfam PF00128 Alpha amylase, catalytic domain 96 459 7.6E-98 T 09-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 TK78_RS26390 9acfcef90d52d7f4ee56f1c7a7712854 1772 TIGRFAM TIGR02103 pullul_strch: alpha-1,6-glucosidases, pullulanase-type 916 1770 4.4E-302 T 09-03-2017 IPR011839 Alpha-1,6-glucosidases, pullulanase-type GO:0005975|GO:0051060 TK78_RS26390 9acfcef90d52d7f4ee56f1c7a7712854 1772 Gene3D G3DSA:2.60.40.10 1045 1136 1.2E-15 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS12020 956bcb9db924cc0235872f1298550ad1 320 ProSitePatterns PS00894 DeoR-type HTH domain signature. 6 40 - T 09-03-2017 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 TK78_RS12020 956bcb9db924cc0235872f1298550ad1 320 Pfam PF08220 DeoR-like helix-turn-helix domain 6 58 2.2E-14 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS12020 956bcb9db924cc0235872f1298550ad1 320 SUPERFAMILY SSF100950 76 235 8.79E-29 T 09-03-2017 TK78_RS12020 956bcb9db924cc0235872f1298550ad1 320 Pfam PF00455 DeoR C terminal sensor domain 76 233 1.0E-49 T 09-03-2017 IPR014036 DeoR C-terminal sensor domain TK78_RS12020 956bcb9db924cc0235872f1298550ad1 320 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 38 56 5.7E-8 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS12020 956bcb9db924cc0235872f1298550ad1 320 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 24 38 5.7E-8 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS12020 956bcb9db924cc0235872f1298550ad1 320 Gene3D G3DSA:3.40.50.1360 77 226 2.0E-12 T 09-03-2017 TK78_RS12020 956bcb9db924cc0235872f1298550ad1 320 SMART SM01134 73 234 6.9E-64 T 09-03-2017 TK78_RS12020 956bcb9db924cc0235872f1298550ad1 320 SMART SM00420 6 58 2.8E-14 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS12020 956bcb9db924cc0235872f1298550ad1 320 Gene3D G3DSA:1.10.10.10 5 56 1.3E-9 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS12020 956bcb9db924cc0235872f1298550ad1 320 SUPERFAMILY SSF46785 5 59 1.99E-13 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05735 c6227fef1cc50f27af52031e27c6af92 334 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 133 145 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS05735 c6227fef1cc50f27af52031e27c6af92 334 Pfam PF00069 Protein kinase domain 16 259 7.6E-37 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS05735 c6227fef1cc50f27af52031e27c6af92 334 SMART SM00220 15 264 2.7E-42 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS05735 c6227fef1cc50f27af52031e27c6af92 334 Gene3D G3DSA:3.30.200.20 7 89 1.9E-15 T 09-03-2017 TK78_RS05735 c6227fef1cc50f27af52031e27c6af92 334 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 21 43 - T 09-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 TK78_RS05735 c6227fef1cc50f27af52031e27c6af92 334 SUPERFAMILY SSF56112 12 260 2.7E-61 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS05735 c6227fef1cc50f27af52031e27c6af92 334 Gene3D G3DSA:1.10.510.10 98 262 6.3E-36 T 09-03-2017 TK78_RS02345 d6f2b92b20222b10a440c98a54995948 494 Gene3D G3DSA:3.40.50.720 335 468 2.1E-44 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS02345 d6f2b92b20222b10a440c98a54995948 494 Gene3D G3DSA:3.40.50.720 139 242 2.1E-44 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS02345 d6f2b92b20222b10a440c98a54995948 494 Pfam PF00106 short chain dehydrogenase 158 245 3.4E-9 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS02345 d6f2b92b20222b10a440c98a54995948 494 SUPERFAMILY SSF51735 339 440 1.81E-26 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS02345 d6f2b92b20222b10a440c98a54995948 494 SUPERFAMILY SSF51735 152 250 1.81E-26 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS17485 49da796b6359b82907d6f3a4f93a7be0 237 TIGRFAM TIGR01076 sortase_fam: sortase 99 220 3.0E-14 T 09-03-2017 IPR005754 Sortase family TK78_RS17485 49da796b6359b82907d6f3a4f93a7be0 237 Gene3D G3DSA:2.40.260.10 84 225 1.2E-23 T 09-03-2017 IPR023365 Sortase domain TK78_RS17485 49da796b6359b82907d6f3a4f93a7be0 237 Pfam PF04203 Sortase family 90 221 6.9E-27 T 09-03-2017 IPR005754 Sortase family TK78_RS17485 49da796b6359b82907d6f3a4f93a7be0 237 SUPERFAMILY SSF63817 79 224 2.75E-29 T 09-03-2017 IPR023365 Sortase domain TK78_RS34375 9055c8e9c251899ea5355710697e83f4 313 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 7 65 7.7E-17 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS34375 9055c8e9c251899ea5355710697e83f4 313 Gene3D G3DSA:3.40.190.10 94 194 1.7E-37 T 09-03-2017 TK78_RS34375 9055c8e9c251899ea5355710697e83f4 313 SUPERFAMILY SSF53850 95 298 1.5E-21 T 09-03-2017 TK78_RS34375 9055c8e9c251899ea5355710697e83f4 313 SUPERFAMILY SSF46785 6 114 1.01E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS34375 9055c8e9c251899ea5355710697e83f4 313 TIGRFAM TIGR03298 argP: transcriptional regulator, ArgP family 8 299 1.6E-104 T 09-03-2017 IPR017685 HTH-type transcriptional regulator ArgP TK78_RS34375 9055c8e9c251899ea5355710697e83f4 313 Pfam PF03466 LysR substrate binding domain 96 296 2.4E-17 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS34375 9055c8e9c251899ea5355710697e83f4 313 Gene3D G3DSA:1.10.10.10 6 85 1.2E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS34375 9055c8e9c251899ea5355710697e83f4 313 Gene3D G3DSA:3.40.190.10 195 263 0.001 T 09-03-2017 TK78_RS07855 557b5f4f8fe03e6324d3177017f30dc6 567 TIGRFAM TIGR00409 proS_fam_II: proline--tRNA ligase 6 560 1.1E-171 T 09-03-2017 IPR004500 Prolyl-tRNA synthetase, class IIa, bacterial-type GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15|Reactome: R-HSA-379726 TK78_RS07855 557b5f4f8fe03e6324d3177017f30dc6 567 SUPERFAMILY SSF55681 14 241 1.42E-87 T 09-03-2017 TK78_RS07855 557b5f4f8fe03e6324d3177017f30dc6 567 SUPERFAMILY SSF55681 406 477 1.42E-87 T 09-03-2017 TK78_RS07855 557b5f4f8fe03e6324d3177017f30dc6 567 PRINTS PR01046 Prolyl-tRNA synthetase signature 108 119 3.8E-16 T 09-03-2017 IPR002316 Proline-tRNA ligase, class IIa GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15|Reactome: R-HSA-379726 TK78_RS07855 557b5f4f8fe03e6324d3177017f30dc6 567 PRINTS PR01046 Prolyl-tRNA synthetase signature 138 146 3.8E-16 T 09-03-2017 IPR002316 Proline-tRNA ligase, class IIa GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15|Reactome: R-HSA-379726 TK78_RS07855 557b5f4f8fe03e6324d3177017f30dc6 567 PRINTS PR01046 Prolyl-tRNA synthetase signature 148 159 3.8E-16 T 09-03-2017 IPR002316 Proline-tRNA ligase, class IIa GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15|Reactome: R-HSA-379726 TK78_RS07855 557b5f4f8fe03e6324d3177017f30dc6 567 PRINTS PR01046 Prolyl-tRNA synthetase signature 72 90 3.8E-16 T 09-03-2017 IPR002316 Proline-tRNA ligase, class IIa GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15|Reactome: R-HSA-379726 TK78_RS07855 557b5f4f8fe03e6324d3177017f30dc6 567 Hamap MF_01569 Proline--tRNA ligase [proS]. 5 567 36.156 T 09-03-2017 IPR023717 Prolyl-tRNA synthetase, class IIa, type 1 GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15 TK78_RS07855 557b5f4f8fe03e6324d3177017f30dc6 567 SUPERFAMILY SSF52954 460 563 3.93E-23 T 09-03-2017 IPR004154 Anticodon-binding TK78_RS07855 557b5f4f8fe03e6324d3177017f30dc6 567 Pfam PF03129 Anticodon binding domain 475 563 1.8E-15 T 09-03-2017 IPR004154 Anticodon-binding TK78_RS07855 557b5f4f8fe03e6324d3177017f30dc6 567 SUPERFAMILY SSF55826 222 387 9.29E-20 T 09-03-2017 IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain GO:0002161 KEGG: 00970+6.1.1.15 TK78_RS07855 557b5f4f8fe03e6324d3177017f30dc6 567 Pfam PF00587 tRNA synthetase class II core domain (G, H, P, S and T) 98 457 3.0E-40 T 09-03-2017 IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS07855 557b5f4f8fe03e6324d3177017f30dc6 567 Gene3D G3DSA:3.30.930.10 388 468 1.9E-94 T 09-03-2017 TK78_RS07855 557b5f4f8fe03e6324d3177017f30dc6 567 Gene3D G3DSA:3.30.930.10 15 238 1.9E-94 T 09-03-2017 TK78_RS07855 557b5f4f8fe03e6324d3177017f30dc6 567 Gene3D G3DSA:3.40.50.800 469 566 1.8E-21 T 09-03-2017 IPR004154 Anticodon-binding TK78_RS07855 557b5f4f8fe03e6324d3177017f30dc6 567 Pfam PF04073 Aminoacyl-tRNA editing domain 260 378 2.6E-26 T 09-03-2017 IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain GO:0002161 KEGG: 00970+6.1.1.15 TK78_RS07855 557b5f4f8fe03e6324d3177017f30dc6 567 Gene3D G3DSA:3.90.960.10 259 384 1.0E-18 T 09-03-2017 IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain GO:0002161 KEGG: 00970+6.1.1.15 TK78_RS03060 227ca8e0b69b5593a1040b47deda260d 213 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 15 28 2.7E-5 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS03060 227ca8e0b69b5593a1040b47deda260d 213 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 36 59 2.7E-5 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS03060 227ca8e0b69b5593a1040b47deda260d 213 Pfam PF00440 Bacterial regulatory proteins, tetR family 15 61 3.5E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS03060 227ca8e0b69b5593a1040b47deda260d 213 SUPERFAMILY SSF48498 82 193 7.91E-20 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS03060 227ca8e0b69b5593a1040b47deda260d 213 Pfam PF13977 Bacterial transcriptional repressor 85 194 1.1E-21 T 09-03-2017 TK78_RS03060 227ca8e0b69b5593a1040b47deda260d 213 SUPERFAMILY SSF46689 5 85 1.95E-14 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS03060 227ca8e0b69b5593a1040b47deda260d 213 Gene3D G3DSA:1.10.357.10 9 192 1.9E-35 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS31040 d8d8749b6bd7f74229ba73f32b8c3062 1119 SUPERFAMILY SSF47336 959 1043 1.7E-15 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31040 d8d8749b6bd7f74229ba73f32b8c3062 1119 Gene3D G3DSA:3.40.366.10 569 693 1.3E-69 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS31040 d8d8749b6bd7f74229ba73f32b8c3062 1119 Gene3D G3DSA:3.40.366.10 763 876 1.3E-69 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS31040 d8d8749b6bd7f74229ba73f32b8c3062 1119 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 197 213 - T 09-03-2017 IPR018201 Beta-ketoacyl synthase, active site TK78_RS31040 d8d8749b6bd7f74229ba73f32b8c3062 1119 SUPERFAMILY SSF55048 699 759 1.11E-9 T 09-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 TK78_RS31040 d8d8749b6bd7f74229ba73f32b8c3062 1119 SMART SM00825 Beta-ketoacyl synthase 36 462 1.5E-216 T 09-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TK78_RS31040 d8d8749b6bd7f74229ba73f32b8c3062 1119 Gene3D G3DSA:3.40.47.10 36 296 9.6E-91 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31040 d8d8749b6bd7f74229ba73f32b8c3062 1119 Pfam PF00550 Phosphopantetheine attachment site 968 1033 5.3E-8 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31040 d8d8749b6bd7f74229ba73f32b8c3062 1119 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 292 409 4.9E-43 T 09-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal TK78_RS31040 d8d8749b6bd7f74229ba73f32b8c3062 1119 SUPERFAMILY SSF53901 31 406 8.43E-101 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31040 d8d8749b6bd7f74229ba73f32b8c3062 1119 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 412 511 3.4E-9 T 09-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31040 d8d8749b6bd7f74229ba73f32b8c3062 1119 Gene3D G3DSA:3.30.70.250 700 755 1.0E-5 T 09-03-2017 TK78_RS31040 d8d8749b6bd7f74229ba73f32b8c3062 1119 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 34 284 1.9E-90 T 09-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal TK78_RS31040 d8d8749b6bd7f74229ba73f32b8c3062 1119 SUPERFAMILY SSF52151 765 858 4.45E-65 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS31040 d8d8749b6bd7f74229ba73f32b8c3062 1119 SUPERFAMILY SSF52151 571 699 4.45E-65 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS31040 d8d8749b6bd7f74229ba73f32b8c3062 1119 Pfam PF08990 Erythronolide synthase docking 2 27 2.3E-8 T 09-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 TK78_RS31040 d8d8749b6bd7f74229ba73f32b8c3062 1119 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 575 874 3.5E-101 T 09-03-2017 IPR020801 Polyketide synthase, acyl transferase domain TK78_RS31040 d8d8749b6bd7f74229ba73f32b8c3062 1119 Gene3D G3DSA:1.10.1200.10 963 1037 1.7E-16 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31040 d8d8749b6bd7f74229ba73f32b8c3062 1119 SMART SM00823 Phosphopantetheine attachment site 965 1037 1.4E-18 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31040 d8d8749b6bd7f74229ba73f32b8c3062 1119 Pfam PF00698 Acyl transferase domain 573 893 1.8E-78 T 09-03-2017 IPR014043 Acyl transferase TK78_RS31040 d8d8749b6bd7f74229ba73f32b8c3062 1119 Gene3D G3DSA:3.40.47.10 297 463 5.3E-63 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS15905 625b6d7d769d2c63f134c8f2d4615371 296 SUPERFAMILY SSF51055 21 78 6.67E-17 T 09-03-2017 IPR003610 Carbohydrate-binding module family 5/12 GO:0004553|GO:0005576|GO:0005975|GO:0030246 TK78_RS15905 625b6d7d769d2c63f134c8f2d4615371 296 PIRSF PIRSF001060 2 296 2.4E-87 T 09-03-2017 IPR016283 Glycoside hydrolase, family 19 GO:0004568|GO:0005975 KEGG: 00520+3.2.1.14|MetaCyc: PWY-6902 TK78_RS15905 625b6d7d769d2c63f134c8f2d4615371 296 Gene3D G3DSA:3.30.20.10 161 215 1.7E-24 T 09-03-2017 TK78_RS15905 625b6d7d769d2c63f134c8f2d4615371 296 Gene3D G3DSA:1.10.530.10 94 152 9.6E-56 T 09-03-2017 TK78_RS15905 625b6d7d769d2c63f134c8f2d4615371 296 Gene3D G3DSA:1.10.530.10 216 296 9.6E-56 T 09-03-2017 TK78_RS15905 625b6d7d769d2c63f134c8f2d4615371 296 Pfam PF02839 Carbohydrate binding domain 35 72 6.9E-10 T 09-03-2017 IPR003610 Carbohydrate-binding module family 5/12 GO:0004553|GO:0005576|GO:0005975|GO:0030246 TK78_RS15905 625b6d7d769d2c63f134c8f2d4615371 296 Gene3D G3DSA:2.10.10.20 30 79 8.6E-20 T 09-03-2017 IPR003610 Carbohydrate-binding module family 5/12 GO:0004553|GO:0005576|GO:0005975|GO:0030246 TK78_RS15905 625b6d7d769d2c63f134c8f2d4615371 296 SMART SM00495 33 75 5.8E-14 T 09-03-2017 IPR003610 Carbohydrate-binding module family 5/12 GO:0004553|GO:0005576|GO:0005975|GO:0030246 TK78_RS15905 625b6d7d769d2c63f134c8f2d4615371 296 Pfam PF00182 Chitinase class I 94 296 4.2E-42 T 09-03-2017 IPR000726 Glycoside hydrolase, family 19, catalytic GO:0004568|GO:0006032|GO:0016998 KEGG: 00520+3.2.1.14|MetaCyc: PWY-6902 TK78_RS15905 625b6d7d769d2c63f134c8f2d4615371 296 SUPERFAMILY SSF53955 93 296 1.49E-68 T 09-03-2017 IPR023346 Lysozyme-like domain TK78_RS10755 b40b69d2fd2adc9154b4ab08fa714489 186 Pfam PF06210 Protein of unknown function (DUF1003) 56 157 1.6E-41 T 09-03-2017 IPR010406 Protein of unknown function DUF1003 TK78_RS03405 0c3728c2e34393b39fec76019c931a09 362 SUPERFAMILY SSF49503 73 185 2.89E-18 T 09-03-2017 IPR008972 Cupredoxin TK78_RS03405 0c3728c2e34393b39fec76019c931a09 362 Gene3D G3DSA:2.60.40.420 38 179 3.1E-27 T 09-03-2017 IPR008972 Cupredoxin TK78_RS03405 0c3728c2e34393b39fec76019c931a09 362 Pfam PF07732 Multicopper oxidase 73 182 5.5E-11 T 09-03-2017 IPR011707 Multicopper oxidase, type 3 GO:0005507 TK78_RS03405 0c3728c2e34393b39fec76019c931a09 362 SUPERFAMILY SSF49503 198 310 1.99E-20 T 09-03-2017 IPR008972 Cupredoxin TK78_RS03405 0c3728c2e34393b39fec76019c931a09 362 ProSitePatterns PS00080 Multicopper oxidases signature 2. 287 298 - T 09-03-2017 IPR002355 Multicopper oxidase, copper-binding site GO:0005507 TK78_RS03405 0c3728c2e34393b39fec76019c931a09 362 Pfam PF07731 Multicopper oxidase 196 306 1.5E-12 T 09-03-2017 IPR011706 Multicopper oxidase, type 2 GO:0005507|GO:0016491|GO:0055114 TK78_RS03405 0c3728c2e34393b39fec76019c931a09 362 Gene3D G3DSA:2.60.40.420 196 310 5.4E-18 T 09-03-2017 IPR008972 Cupredoxin TK78_RS17365 a39bf9a8053a1d8be5f955df9b0e06de 633 Gene3D G3DSA:3.40.50.300 292 458 1.5E-61 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17365 a39bf9a8053a1d8be5f955df9b0e06de 633 Hamap MF_00377 Chromosomal replication initiator protein DnaA [dnaA]. 9 631 33.143 T 09-03-2017 IPR001957 Chromosomal replication control, initiator DnaA GO:0003677|GO:0003688|GO:0005524|GO:0006270|GO:0006275 TK78_RS17365 a39bf9a8053a1d8be5f955df9b0e06de 633 SMART SM00382 326 454 9.9E-10 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS17365 a39bf9a8053a1d8be5f955df9b0e06de 633 Pfam PF08299 Bacterial dnaA protein helix-turn-helix 543 609 9.5E-30 T 09-03-2017 IPR013159 Chromosomal replication initiator, DnaA C-terminal GO:0005524|GO:0006270|GO:0006275|GO:0043565 TK78_RS17365 a39bf9a8053a1d8be5f955df9b0e06de 633 SMART SM00760 540 609 2.0E-36 T 09-03-2017 IPR013159 Chromosomal replication initiator, DnaA C-terminal GO:0005524|GO:0006270|GO:0006275|GO:0043565 TK78_RS17365 a39bf9a8053a1d8be5f955df9b0e06de 633 TIGRFAM TIGR00362 DnaA: chromosomal replication initiator protein DnaA 249 630 3.6E-150 T 09-03-2017 IPR001957 Chromosomal replication control, initiator DnaA GO:0003677|GO:0003688|GO:0005524|GO:0006270|GO:0006275 TK78_RS17365 a39bf9a8053a1d8be5f955df9b0e06de 633 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 327 347 3.3E-52 T 09-03-2017 IPR020591 Chromosomal replication control, initiator DnaA-like TK78_RS17365 a39bf9a8053a1d8be5f955df9b0e06de 633 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 590 609 3.3E-52 T 09-03-2017 IPR020591 Chromosomal replication control, initiator DnaA-like TK78_RS17365 a39bf9a8053a1d8be5f955df9b0e06de 633 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 391 405 3.3E-52 T 09-03-2017 IPR020591 Chromosomal replication control, initiator DnaA-like TK78_RS17365 a39bf9a8053a1d8be5f955df9b0e06de 633 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 359 373 3.3E-52 T 09-03-2017 IPR020591 Chromosomal replication control, initiator DnaA-like TK78_RS17365 a39bf9a8053a1d8be5f955df9b0e06de 633 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 425 452 3.3E-52 T 09-03-2017 IPR020591 Chromosomal replication control, initiator DnaA-like TK78_RS17365 a39bf9a8053a1d8be5f955df9b0e06de 633 Pfam PF00308 Bacterial dnaA protein 294 511 2.1E-103 T 09-03-2017 IPR013317 Chromosomal replication initiator protein DnaA TK78_RS17365 a39bf9a8053a1d8be5f955df9b0e06de 633 ProSitePatterns PS01008 DnaA protein signature. 590 609 - T 09-03-2017 IPR018312 Chromosomal replication control, initiator DnaA, conserved site GO:0003677|GO:0003688|GO:0005524|GO:0006270|GO:0006275 TK78_RS17365 a39bf9a8053a1d8be5f955df9b0e06de 633 SUPERFAMILY SSF48295 537 632 2.62E-34 T 09-03-2017 IPR010921 Trp repressor/replication initiator GO:0043565 TK78_RS17365 a39bf9a8053a1d8be5f955df9b0e06de 633 Gene3D G3DSA:1.10.8.60 460 529 2.0E-28 T 09-03-2017 TK78_RS17365 a39bf9a8053a1d8be5f955df9b0e06de 633 SUPERFAMILY SSF52540 293 505 3.99E-44 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17365 a39bf9a8053a1d8be5f955df9b0e06de 633 Gene3D G3DSA:1.10.1750.10 534 632 1.5E-38 T 09-03-2017 IPR013159 Chromosomal replication initiator, DnaA C-terminal GO:0005524|GO:0006270|GO:0006275|GO:0043565 TK78_RS11680 370b48dcac2c43160dc89ed0678a6124 252 Gene3D G3DSA:3.30.450.40 71 247 2.2E-56 T 09-03-2017 IPR029016 GAF domain-like TK78_RS11680 370b48dcac2c43160dc89ed0678a6124 252 SMART SM00346 2 89 2.1E-25 T 09-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 TK78_RS11680 370b48dcac2c43160dc89ed0678a6124 252 SUPERFAMILY SSF55781 57 243 4.07E-48 T 09-03-2017 IPR029016 GAF domain-like TK78_RS11680 370b48dcac2c43160dc89ed0678a6124 252 SUPERFAMILY SSF46785 3 72 4.97E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS11680 370b48dcac2c43160dc89ed0678a6124 252 Gene3D G3DSA:1.10.10.10 2 70 2.6E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS11680 370b48dcac2c43160dc89ed0678a6124 252 Pfam PF09339 IclR helix-turn-helix domain 4 52 2.3E-14 T 09-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 TK78_RS11680 370b48dcac2c43160dc89ed0678a6124 252 Pfam PF01614 Bacterial transcriptional regulator 117 241 9.9E-29 T 09-03-2017 IPR014757 Transcription regulator IclR, C-terminal TK78_RS15630 854e2eacabd532f2d4b925b723025e5d 918 Gene3D G3DSA:3.90.1170.50 148 270 1.3E-40 T 09-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead TK78_RS15630 854e2eacabd532f2d4b925b723025e5d 918 Gene3D G3DSA:3.30.365.10 445 519 1.0E-39 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS15630 854e2eacabd532f2d4b925b723025e5d 918 Gene3D G3DSA:3.30.365.10 271 333 1.0E-39 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS15630 854e2eacabd532f2d4b925b723025e5d 918 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 38 46 - T 09-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 TK78_RS15630 854e2eacabd532f2d4b925b723025e5d 918 SUPERFAMILY SSF54665 151 301 1.07E-43 T 09-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead TK78_RS15630 854e2eacabd532f2d4b925b723025e5d 918 Gene3D G3DSA:3.30.365.10 745 910 6.3E-52 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS15630 854e2eacabd532f2d4b925b723025e5d 918 Gene3D G3DSA:3.30.365.10 334 441 3.2E-35 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS15630 854e2eacabd532f2d4b925b723025e5d 918 Gene3D G3DSA:1.10.150.120 74 147 1.6E-24 T 09-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 TK78_RS15630 854e2eacabd532f2d4b925b723025e5d 918 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 312 849 5.2E-147 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS15630 854e2eacabd532f2d4b925b723025e5d 918 Pfam PF01799 [2Fe-2S] binding domain 72 141 3.4E-24 T 09-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 TK78_RS15630 854e2eacabd532f2d4b925b723025e5d 918 SUPERFAMILY SSF56003 285 911 8.77E-173 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS15630 854e2eacabd532f2d4b925b723025e5d 918 SUPERFAMILY SSF54292 3 77 3.54E-19 T 09-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 TK78_RS15630 854e2eacabd532f2d4b925b723025e5d 918 SMART SM01008 170 282 5.4E-51 T 09-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead TK78_RS15630 854e2eacabd532f2d4b925b723025e5d 918 Gene3D G3DSA:3.30.365.10 608 744 2.6E-32 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS15630 854e2eacabd532f2d4b925b723025e5d 918 SUPERFAMILY SSF47741 84 148 1.96E-22 T 09-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 TK78_RS15630 854e2eacabd532f2d4b925b723025e5d 918 Pfam PF01315 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain 170 282 1.4E-28 T 09-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead TK78_RS15630 854e2eacabd532f2d4b925b723025e5d 918 Gene3D G3DSA:3.10.20.30 3 73 2.7E-24 T 09-03-2017 IPR012675 Beta-grasp domain TK78_RS08615 c5368098f043c88e83ecb5d5f79554b3 334 Gene3D G3DSA:3.40.50.620 156 293 3.1E-31 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS08615 c5368098f043c88e83ecb5d5f79554b3 334 Pfam PF02698 DUF218 domain 159 306 1.2E-28 T 09-03-2017 IPR003848 Domain of unknown function DUF218 TK78_RS21830 269ef84ad71ad36aa23b535af735c112 447 SUPERFAMILY SSF52413 321 439 3.53E-32 T 09-03-2017 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 TK78_RS21830 269ef84ad71ad36aa23b535af735c112 447 Pfam PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 210 303 1.7E-29 T 09-03-2017 IPR014026 UDP-glucose/GDP-mannose dehydrogenase, dimerisation GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 TK78_RS21830 269ef84ad71ad36aa23b535af735c112 447 Pfam PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 4 191 5.9E-55 T 09-03-2017 IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 TK78_RS21830 269ef84ad71ad36aa23b535af735c112 447 TIGRFAM TIGR03026 NDP-sugDHase: nucleotide sugar dehydrogenase 4 425 9.2E-122 T 09-03-2017 IPR017476 UDP-glucose/GDP-mannose dehydrogenase GO:0016616|GO:0055114 Reactome: R-HSA-173599 TK78_RS21830 269ef84ad71ad36aa23b535af735c112 447 SUPERFAMILY SSF51735 4 196 1.4E-45 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS21830 269ef84ad71ad36aa23b535af735c112 447 SUPERFAMILY SSF48179 210 308 8.67E-26 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS21830 269ef84ad71ad36aa23b535af735c112 447 Pfam PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 328 428 6.2E-25 T 09-03-2017 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 TK78_RS21830 269ef84ad71ad36aa23b535af735c112 447 Gene3D G3DSA:3.40.50.720 242 446 1.7E-64 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS21830 269ef84ad71ad36aa23b535af735c112 447 PIRSF PIRSF000124 3 444 1.8E-111 T 09-03-2017 IPR017476 UDP-glucose/GDP-mannose dehydrogenase GO:0016616|GO:0055114 Reactome: R-HSA-173599 TK78_RS21830 269ef84ad71ad36aa23b535af735c112 447 SMART SM00984 328 429 6.2E-42 T 09-03-2017 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 TK78_RS21830 269ef84ad71ad36aa23b535af735c112 447 PIRSF PIRSF500134 3 447 6.2E-150 T 09-03-2017 IPR028357 UDP-glucose 6-dehydrogenase, bacterial type GO:0000271|GO:0003979 KEGG: 00040+1.1.1.22|KEGG: 00053+1.1.1.22|KEGG: 00500+1.1.1.22|KEGG: 00520+1.1.1.22|MetaCyc: PWY-7346 TK78_RS21830 269ef84ad71ad36aa23b535af735c112 447 Gene3D G3DSA:1.20.5.100 213 238 1.0E-15 T 09-03-2017 TK78_RS21830 269ef84ad71ad36aa23b535af735c112 447 Gene3D G3DSA:3.40.50.720 4 212 5.3E-68 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS05775 ea18a63b11fd8500d2fb221ba6eca261 249 Pfam PF01738 Dienelactone hydrolase family 24 239 3.3E-27 T 09-03-2017 IPR002925 Dienelactone hydrolase GO:0016787 TK78_RS05775 ea18a63b11fd8500d2fb221ba6eca261 249 Gene3D G3DSA:3.40.50.1820 8 238 2.7E-41 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS05775 ea18a63b11fd8500d2fb221ba6eca261 249 SUPERFAMILY SSF53474 9 239 1.16E-33 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS23405 bda4d7f29c2bd1475573d3288bac46fa 482 PRINTS PR00800 Aromatic-L-amino-acid decarboxylase signature 120 139 4.0E-7 T 09-03-2017 IPR010977 Aromatic-L-amino-acid decarboxylase GO:0006520|GO:0016831 TK78_RS23405 bda4d7f29c2bd1475573d3288bac46fa 482 PRINTS PR00800 Aromatic-L-amino-acid decarboxylase signature 80 99 4.0E-7 T 09-03-2017 IPR010977 Aromatic-L-amino-acid decarboxylase GO:0006520|GO:0016831 TK78_RS23405 bda4d7f29c2bd1475573d3288bac46fa 482 PRINTS PR00800 Aromatic-L-amino-acid decarboxylase signature 343 358 4.0E-7 T 09-03-2017 IPR010977 Aromatic-L-amino-acid decarboxylase GO:0006520|GO:0016831 TK78_RS23405 bda4d7f29c2bd1475573d3288bac46fa 482 PRINTS PR00800 Aromatic-L-amino-acid decarboxylase signature 386 405 4.0E-7 T 09-03-2017 IPR010977 Aromatic-L-amino-acid decarboxylase GO:0006520|GO:0016831 TK78_RS23405 bda4d7f29c2bd1475573d3288bac46fa 482 Gene3D G3DSA:3.40.640.10 90 357 7.0E-92 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS23405 bda4d7f29c2bd1475573d3288bac46fa 482 Gene3D G3DSA:1.20.1650.10 4 79 3.8E-23 T 09-03-2017 TK78_RS23405 bda4d7f29c2bd1475573d3288bac46fa 482 Pfam PF00282 Pyridoxal-dependent decarboxylase conserved domain 79 404 7.6E-60 T 09-03-2017 IPR002129 Pyridoxal phosphate-dependent decarboxylase GO:0016831|GO:0019752|GO:0030170 TK78_RS23405 bda4d7f29c2bd1475573d3288bac46fa 482 SUPERFAMILY SSF53383 32 472 5.67E-115 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS23405 bda4d7f29c2bd1475573d3288bac46fa 482 Gene3D G3DSA:3.90.1150.10 358 472 1.6E-43 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS16995 86df595f6c4dd45f8fedbe498484d1ca 311 PIRSF PIRSF001500 2 279 1.4E-58 T 09-03-2017 IPR008242 Bifunctional P-protein, chorismate mutase/prephenate dehydratase GO:0004106|GO:0004664|GO:0005737|GO:0009094 KEGG: 00400+4.2.1.51|MetaCyc: PWY-7432 TK78_RS16995 86df595f6c4dd45f8fedbe498484d1ca 311 Gene3D G3DSA:3.30.70.260 190 277 7.8E-28 T 09-03-2017 TK78_RS16995 86df595f6c4dd45f8fedbe498484d1ca 311 Gene3D G3DSA:3.40.190.10 94 171 4.9E-20 T 09-03-2017 TK78_RS16995 86df595f6c4dd45f8fedbe498484d1ca 311 Gene3D G3DSA:3.40.190.10 4 93 9.2E-25 T 09-03-2017 TK78_RS16995 86df595f6c4dd45f8fedbe498484d1ca 311 Pfam PF00800 Prephenate dehydratase 7 184 9.0E-47 T 09-03-2017 IPR001086 Prephenate dehydratase GO:0004664|GO:0009094 KEGG: 00400+4.2.1.51|MetaCyc: PWY-7432 TK78_RS16995 86df595f6c4dd45f8fedbe498484d1ca 311 SUPERFAMILY SSF53850 5 188 2.63E-50 T 09-03-2017 TK78_RS16995 86df595f6c4dd45f8fedbe498484d1ca 311 Pfam PF01842 ACT domain 197 259 2.8E-7 T 09-03-2017 IPR002912 ACT domain GO:0008152|GO:0016597 TK78_RS16995 86df595f6c4dd45f8fedbe498484d1ca 311 SUPERFAMILY SSF55021 178 276 1.48E-21 T 09-03-2017 TK78_RS16995 86df595f6c4dd45f8fedbe498484d1ca 311 ProSitePatterns PS00857 Prephenate dehydratase signature 1. 159 181 - T 09-03-2017 IPR018528 Prephenate dehydratase, conserved site GO:0004664|GO:0009094 KEGG: 00400+4.2.1.51|MetaCyc: PWY-7432 TK78_RS03715 c59fff884eb926d6f8756141d308c8f9 537 SUPERFAMILY SSF51905 458 519 5.3E-70 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS03715 c59fff884eb926d6f8756141d308c8f9 537 SUPERFAMILY SSF51905 16 293 5.3E-70 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS03715 c59fff884eb926d6f8756141d308c8f9 537 ProSitePatterns PS00624 GMC oxidoreductases signature 2. 259 273 - T 09-03-2017 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal GO:0016614|GO:0050660|GO:0055114 Reactome: R-HSA-6798163 TK78_RS03715 c59fff884eb926d6f8756141d308c8f9 537 Pfam PF00732 GMC oxidoreductase 17 301 4.3E-57 T 09-03-2017 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal GO:0016614|GO:0050660|GO:0055114 Reactome: R-HSA-6798163 TK78_RS03715 c59fff884eb926d6f8756141d308c8f9 537 Gene3D G3DSA:3.50.50.60 16 136 4.5E-104 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS03715 c59fff884eb926d6f8756141d308c8f9 537 Gene3D G3DSA:3.50.50.60 188 318 4.5E-104 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS03715 c59fff884eb926d6f8756141d308c8f9 537 Gene3D G3DSA:3.50.50.60 452 518 4.5E-104 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS03715 c59fff884eb926d6f8756141d308c8f9 537 SUPERFAMILY SSF54373 295 459 4.61E-42 T 09-03-2017 TK78_RS03715 c59fff884eb926d6f8756141d308c8f9 537 Pfam PF05199 GMC oxidoreductase 371 511 9.3E-40 T 09-03-2017 IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal GO:0016614|GO:0055114 Reactome: R-HSA-6798163 TK78_RS10090 6825e4913febe378d829506b03410614 131 TIGRFAM TIGR02753 sodN: superoxide dismutase, Ni 1 131 1.5E-54 T 09-03-2017 IPR014123 Superoxide dismutase, Nickel-type GO:0004784|GO:0016151|GO:0016209 MetaCyc: PWY-6854 TK78_RS10090 6825e4913febe378d829506b03410614 131 Pfam PF09055 Nickel-containing superoxide dismutase 11 129 1.4E-42 T 09-03-2017 IPR014123 Superoxide dismutase, Nickel-type GO:0004784|GO:0016151|GO:0016209 MetaCyc: PWY-6854 TK78_RS10090 6825e4913febe378d829506b03410614 131 Gene3D G3DSA:1.20.120.400 15 130 9.2E-50 T 09-03-2017 IPR014123 Superoxide dismutase, Nickel-type GO:0004784|GO:0016151|GO:0016209 MetaCyc: PWY-6854 TK78_RS10090 6825e4913febe378d829506b03410614 131 SUPERFAMILY SSF109770 15 131 1.27E-52 T 09-03-2017 IPR014123 Superoxide dismutase, Nickel-type GO:0004784|GO:0016151|GO:0016209 MetaCyc: PWY-6854 TK78_RS27415 7ea10b79c07e88494a917283c1d8526b 486 PRINTS PR00419 Adrenodoxin reductase family signature 211 221 1.5E-24 T 09-03-2017 TK78_RS27415 7ea10b79c07e88494a917283c1d8526b 486 PRINTS PR00419 Adrenodoxin reductase family signature 285 299 1.5E-24 T 09-03-2017 TK78_RS27415 7ea10b79c07e88494a917283c1d8526b 486 PRINTS PR00419 Adrenodoxin reductase family signature 146 168 1.5E-24 T 09-03-2017 TK78_RS27415 7ea10b79c07e88494a917283c1d8526b 486 PRINTS PR00419 Adrenodoxin reductase family signature 169 182 1.5E-24 T 09-03-2017 TK78_RS27415 7ea10b79c07e88494a917283c1d8526b 486 SUPERFAMILY SSF46548 6 155 5.23E-35 T 09-03-2017 IPR009051 Alpha-helical ferredoxin GO:0051536 TK78_RS27415 7ea10b79c07e88494a917283c1d8526b 486 TIGRFAM TIGR01317 GOGAT_sm_gam: glutamate synthase, NADH/NADPH, small subunit 3 473 2.1E-208 T 09-03-2017 IPR006005 Glutamate synthase, NADH/NADPH, small subunit 1 GO:0006537|GO:0016639|GO:0055114 TK78_RS27415 7ea10b79c07e88494a917283c1d8526b 486 Gene3D G3DSA:3.40.50.720 400 480 6.0E-45 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS27415 7ea10b79c07e88494a917283c1d8526b 486 Gene3D G3DSA:3.40.50.720 148 234 6.0E-45 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS27415 7ea10b79c07e88494a917283c1d8526b 486 Pfam PF14691 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster 40 131 3.1E-20 T 09-03-2017 IPR028261 Dihydroprymidine dehydrogenase domain II Reactome: R-HSA-73621 TK78_RS27415 7ea10b79c07e88494a917283c1d8526b 486 Gene3D G3DSA:1.10.1060.10 2 147 1.9E-35 T 09-03-2017 TK78_RS27415 7ea10b79c07e88494a917283c1d8526b 486 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 146 456 4.3E-32 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS27415 7ea10b79c07e88494a917283c1d8526b 486 SUPERFAMILY SSF51971 144 400 3.65E-66 T 09-03-2017 TK78_RS27415 7ea10b79c07e88494a917283c1d8526b 486 Gene3D G3DSA:3.50.50.60 235 399 8.6E-43 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS02130 ee161025d633faf573ffb34ffb242130 273 Pfam PF10021 Uncharacterized protein conserved in bacteria (DUF2263) 9 154 8.5E-50 T 09-03-2017 IPR019261 Domain of unknown function DUF2263 TK78_RS02130 ee161025d633faf573ffb34ffb242130 273 TIGRFAM TIGR02452 TIGR02452: TIGR02452 family protein 8 270 3.6E-95 T 09-03-2017 IPR012664 Conserved hypothetical protein CHP02452 TK78_RS02130 ee161025d633faf573ffb34ffb242130 273 SUPERFAMILY SSF52949 192 269 7.77E-6 T 09-03-2017 TK78_RS02130 ee161025d633faf573ffb34ffb242130 273 PIRSF PIRSF014899 1 273 9.1E-117 T 09-03-2017 IPR012664 Conserved hypothetical protein CHP02452 TK78_RS33190 0ee9668e7ffcdf2edace04e81c7c3d8d 1009 Gene3D G3DSA:3.20.20.80 891 921 1.8E-92 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS33190 0ee9668e7ffcdf2edace04e81c7c3d8d 1009 Gene3D G3DSA:3.20.20.80 366 376 1.8E-92 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS33190 0ee9668e7ffcdf2edace04e81c7c3d8d 1009 Gene3D G3DSA:3.20.20.80 408 496 1.8E-92 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS33190 0ee9668e7ffcdf2edace04e81c7c3d8d 1009 Gene3D G3DSA:3.20.20.80 558 681 1.8E-92 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS33190 0ee9668e7ffcdf2edace04e81c7c3d8d 1009 Gene3D G3DSA:3.20.20.80 740 858 1.8E-92 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS33190 0ee9668e7ffcdf2edace04e81c7c3d8d 1009 SUPERFAMILY SSF49265 260 355 1.37E-13 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS33190 0ee9668e7ffcdf2edace04e81c7c3d8d 1009 SMART SM00642 375 903 1.6E-37 T 09-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 TK78_RS33190 0ee9668e7ffcdf2edace04e81c7c3d8d 1009 Gene3D G3DSA:2.60.40.10 262 351 7.8E-17 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS33190 0ee9668e7ffcdf2edace04e81c7c3d8d 1009 Pfam PF00128 Alpha amylase, catalytic domain 410 843 6.0E-35 T 09-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 TK78_RS33190 0ee9668e7ffcdf2edace04e81c7c3d8d 1009 SMART SM00060 264 340 5.4E-8 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS33190 0ee9668e7ffcdf2edace04e81c7c3d8d 1009 SUPERFAMILY SSF51445 721 912 5.2E-75 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS33190 0ee9668e7ffcdf2edace04e81c7c3d8d 1009 SUPERFAMILY SSF51445 359 647 5.2E-75 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS33190 0ee9668e7ffcdf2edace04e81c7c3d8d 1009 Pfam PF03423 Carbohydrate binding domain (family 25) 50 147 7.9E-31 T 09-03-2017 IPR005085 Carbohydrate binding module family 25 GO:2001070 TK78_RS33190 0ee9668e7ffcdf2edace04e81c7c3d8d 1009 Pfam PF03423 Carbohydrate binding domain (family 25) 157 259 6.1E-41 T 09-03-2017 IPR005085 Carbohydrate binding module family 25 GO:2001070 TK78_RS33190 0ee9668e7ffcdf2edace04e81c7c3d8d 1009 Gene3D G3DSA:2.60.40.1180 948 987 5.3E-5 T 09-03-2017 IPR013780 Glycosyl hydrolase, all-beta TK78_RS33190 0ee9668e7ffcdf2edace04e81c7c3d8d 1009 Pfam PF00041 Fibronectin type III domain 265 338 1.7E-5 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS33190 0ee9668e7ffcdf2edace04e81c7c3d8d 1009 SMART SM01066 157 237 2.8E-23 T 09-03-2017 IPR005085 Carbohydrate binding module family 25 GO:2001070 TK78_RS33190 0ee9668e7ffcdf2edace04e81c7c3d8d 1009 SMART SM01066 48 128 7.3E-23 T 09-03-2017 IPR005085 Carbohydrate binding module family 25 GO:2001070 TK78_RS30495 24c8e20f6c3b1d52501e40d945ca169d 452 Pfam PF03471 Transporter associated domain 365 435 9.6E-16 T 09-03-2017 IPR005170 Transporter-associated domain TK78_RS30495 24c8e20f6c3b1d52501e40d945ca169d 452 Gene3D G3DSA:3.10.580.10 211 331 8.1E-19 T 09-03-2017 TK78_RS30495 24c8e20f6c3b1d52501e40d945ca169d 452 SUPERFAMILY SSF56176 365 440 2.21E-15 T 09-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 TK78_RS30495 24c8e20f6c3b1d52501e40d945ca169d 452 SUPERFAMILY SSF54631 215 347 1.39E-25 T 09-03-2017 TK78_RS30495 24c8e20f6c3b1d52501e40d945ca169d 452 Pfam PF00571 CBS domain 220 273 5.5E-5 T 09-03-2017 IPR000644 CBS domain TK78_RS30495 24c8e20f6c3b1d52501e40d945ca169d 452 Pfam PF00571 CBS domain 292 337 4.7E-6 T 09-03-2017 IPR000644 CBS domain TK78_RS30495 24c8e20f6c3b1d52501e40d945ca169d 452 Gene3D G3DSA:3.30.465.10 332 434 4.6E-23 T 09-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 TK78_RS30495 24c8e20f6c3b1d52501e40d945ca169d 452 SMART SM01091 359 436 1.0E-16 T 09-03-2017 IPR005170 Transporter-associated domain TK78_RS30495 24c8e20f6c3b1d52501e40d945ca169d 452 Pfam PF01595 Domain of unknown function DUF21 10 202 1.9E-37 T 09-03-2017 IPR002550 Domain of unknown function DUF21 TK78_RS24540 9f47ed56e875cd045bc56611ab207199 499 Gene3D G3DSA:3.90.550.10 8 245 6.1E-58 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS24540 9f47ed56e875cd045bc56611ab207199 499 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 323 334 1.6E-6 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS24540 9f47ed56e875cd045bc56611ab207199 499 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 395 414 1.6E-6 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS24540 9f47ed56e875cd045bc56611ab207199 499 SUPERFAMILY SSF53448 11 244 3.55E-45 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS24540 9f47ed56e875cd045bc56611ab207199 499 PIRSF PIRSF036586 6 479 7.1E-169 T 09-03-2017 IPR012115 Bifunctional ribulose 5-phosphate reductase/CDP-ribitol pyrophosphorylase TK78_RS24540 9f47ed56e875cd045bc56611ab207199 499 Pfam PF01128 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 12 240 2.5E-43 T 09-03-2017 IPR001228 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase GO:0008299|GO:0050518 KEGG: 00900+2.7.7.60|MetaCyc: PWY-7560 TK78_RS24540 9f47ed56e875cd045bc56611ab207199 499 SUPERFAMILY SSF51735 264 471 6.32E-43 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS24540 9f47ed56e875cd045bc56611ab207199 499 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 323 334 2.8E-18 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS24540 9f47ed56e875cd045bc56611ab207199 499 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 395 414 2.8E-18 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS24540 9f47ed56e875cd045bc56611ab207199 499 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 416 433 2.8E-18 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS24540 9f47ed56e875cd045bc56611ab207199 499 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 268 285 2.8E-18 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS24540 9f47ed56e875cd045bc56611ab207199 499 Hamap MF_00108 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [ispD]. 10 247 26.099 T 09-03-2017 IPR001228 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase GO:0008299|GO:0050518 KEGG: 00900+2.7.7.60|MetaCyc: PWY-7560 TK78_RS24540 9f47ed56e875cd045bc56611ab207199 499 Pfam PF00106 short chain dehydrogenase 267 437 2.7E-27 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS24540 9f47ed56e875cd045bc56611ab207199 499 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 382 410 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS24540 9f47ed56e875cd045bc56611ab207199 499 Gene3D G3DSA:3.40.50.720 264 470 9.7E-42 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS29340 ef1a5e43d19986e04bac0df342df7b08 588 SMART SM00382 265 419 4.0E-22 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS29340 ef1a5e43d19986e04bac0df342df7b08 588 TIGRFAM TIGR03689 pup_AAA: proteasome ATPase 52 565 3.3E-256 T 09-03-2017 IPR022482 Proteasome ATPase GO:0000502|GO:0010498|GO:0016887|GO:0019941 TK78_RS29340 ef1a5e43d19986e04bac0df342df7b08 588 Gene3D G3DSA:3.40.50.300 218 432 5.7E-59 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29340 ef1a5e43d19986e04bac0df342df7b08 588 Hamap MF_02112 Proteasome-associated ATPase [mpa]. 54 566 50.814 T 09-03-2017 IPR022482 Proteasome ATPase GO:0000502|GO:0010498|GO:0016887|GO:0019941 TK78_RS29340 ef1a5e43d19986e04bac0df342df7b08 588 ProSitePatterns PS00674 AAA-protein family signature. 387 405 - T 09-03-2017 IPR003960 ATPase, AAA-type, conserved site GO:0005524 TK78_RS29340 ef1a5e43d19986e04bac0df342df7b08 588 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 269 417 2.8E-47 T 09-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 TK78_RS29340 ef1a5e43d19986e04bac0df342df7b08 588 Pfam PF16450 Proteasomal ATPase OB/ID domain 97 226 4.2E-53 T 09-03-2017 IPR032501 Proteasomal ATPase, OB/ID domain TK78_RS29340 ef1a5e43d19986e04bac0df342df7b08 588 SUPERFAMILY SSF52540 227 431 9.33E-51 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29340 ef1a5e43d19986e04bac0df342df7b08 588 SUPERFAMILY SSF52540 475 523 9.33E-51 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33035 b028e8bb7eb49c663df1dbc50eb13615 236 SUPERFAMILY SSF53098 4 144 1.05E-39 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS33035 b028e8bb7eb49c663df1dbc50eb13615 236 Hamap MF_00042 Ribonuclease H [rnhA]. 2 154 31.715 T 09-03-2017 IPR022892 Ribonuclease H GO:0004523 TK78_RS33035 b028e8bb7eb49c663df1dbc50eb13615 236 Gene3D G3DSA:3.30.420.10 2 146 1.2E-43 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS33035 b028e8bb7eb49c663df1dbc50eb13615 236 Pfam PF00075 RNase H 3 145 2.3E-29 T 09-03-2017 IPR002156 Ribonuclease H domain GO:0003676|GO:0004523 TK78_RS23230 80b0505c979ba4d42d167b586077b4f9 263 SUPERFAMILY SSF46767 119 193 1.7E-12 T 09-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 TK78_RS23230 80b0505c979ba4d42d167b586077b4f9 263 Gene3D G3DSA:3.40.10.10 199 260 5.2E-18 T 09-03-2017 IPR004026 Ada DNA repair, metal-binding GO:0003677|GO:0006281|GO:0006355|GO:0008168|GO:0008270 TK78_RS23230 80b0505c979ba4d42d167b586077b4f9 263 SUPERFAMILY SSF57884 201 261 5.23E-16 T 09-03-2017 IPR004026 Ada DNA repair, metal-binding GO:0003677|GO:0006281|GO:0006355|GO:0008168|GO:0008270 TK78_RS23230 80b0505c979ba4d42d167b586077b4f9 263 Pfam PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 119 197 2.9E-13 T 09-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 TK78_RS23230 80b0505c979ba4d42d167b586077b4f9 263 Gene3D G3DSA:1.10.10.10 118 198 4.4E-13 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS23230 80b0505c979ba4d42d167b586077b4f9 263 Pfam PF02805 Metal binding domain of Ada 210 260 1.3E-10 T 09-03-2017 IPR004026 Ada DNA repair, metal-binding GO:0003677|GO:0006281|GO:0006355|GO:0008168|GO:0008270 TK78_RS30280 3e1d4c51da1f37cde853534a710d5bb4 188 SUPERFAMILY SSF50249 130 186 1.59E-17 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS30280 3e1d4c51da1f37cde853534a710d5bb4 188 PIRSF PIRSF005901 1 187 1.1E-66 T 09-03-2017 IPR020599 Translation elongation factor P/YeiP TK78_RS30280 3e1d4c51da1f37cde853534a710d5bb4 188 SUPERFAMILY SSF50249 66 127 2.23E-18 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS30280 3e1d4c51da1f37cde853534a710d5bb4 188 Gene3D G3DSA:2.40.50.140 130 186 2.6E-27 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS30280 3e1d4c51da1f37cde853534a710d5bb4 188 SMART SM01185 68 122 1.2E-24 T 09-03-2017 IPR001059 Translation elongation factor P/YeiP, central GO:0003746|GO:0006414 TK78_RS30280 3e1d4c51da1f37cde853534a710d5bb4 188 ProSitePatterns PS01275 Elongation factor P signature. 151 170 - T 09-03-2017 IPR013852 Translation elongation factor P/YeiP, conserved site TK78_RS30280 3e1d4c51da1f37cde853534a710d5bb4 188 Gene3D G3DSA:2.30.30.30 3 64 9.2E-31 T 09-03-2017 IPR014722 Ribosomal protein L2 domain 2 TK78_RS30280 3e1d4c51da1f37cde853534a710d5bb4 188 TIGRFAM TIGR00038 efp: translation elongation factor P 3 186 1.2E-74 T 09-03-2017 IPR011768 Translation elongation factor P GO:0003746|GO:0005737|GO:0006414 TK78_RS30280 3e1d4c51da1f37cde853534a710d5bb4 188 Pfam PF01132 Elongation factor P (EF-P) OB domain 69 122 1.6E-19 T 09-03-2017 IPR001059 Translation elongation factor P/YeiP, central GO:0003746|GO:0006414 TK78_RS30280 3e1d4c51da1f37cde853534a710d5bb4 188 Pfam PF08207 Elongation factor P (EF-P) KOW-like domain 3 61 6.7E-26 T 09-03-2017 IPR013185 Translation elongation factor, KOW-like TK78_RS30280 3e1d4c51da1f37cde853534a710d5bb4 188 SUPERFAMILY SSF50104 2 63 1.32E-18 T 09-03-2017 IPR008991 Translation protein SH3-like domain TK78_RS30280 3e1d4c51da1f37cde853534a710d5bb4 188 SMART SM00841 130 185 2.4E-31 T 09-03-2017 IPR015365 Elongation factor P, C-terminal GO:0005737|GO:0043043 TK78_RS30280 3e1d4c51da1f37cde853534a710d5bb4 188 Gene3D G3DSA:2.40.50.140 66 128 5.5E-24 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS30280 3e1d4c51da1f37cde853534a710d5bb4 188 Pfam PF09285 Elongation factor P, C-terminal 130 185 6.8E-25 T 09-03-2017 IPR015365 Elongation factor P, C-terminal GO:0005737|GO:0043043 TK78_RS30280 3e1d4c51da1f37cde853534a710d5bb4 188 Hamap MF_00141 Elongation factor P [efp]. 1 186 50.549 T 09-03-2017 IPR011768 Translation elongation factor P GO:0003746|GO:0005737|GO:0006414 TK78_RS07915 ab9166f30f28203fe7b785936ea9027c 286 Gene3D G3DSA:1.20.144.10 92 272 1.6E-18 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS07915 ab9166f30f28203fe7b785936ea9027c 286 SUPERFAMILY SSF48317 85 278 1.83E-20 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS07915 ab9166f30f28203fe7b785936ea9027c 286 Pfam PF01569 PAP2 superfamily 185 271 1.1E-9 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS15745 05d717955a8ceffd32bc6a7e3477c481 570 Gene3D G3DSA:3.30.200.20 9 80 7.7E-14 T 09-03-2017 TK78_RS15745 05d717955a8ceffd32bc6a7e3477c481 570 Gene3D G3DSA:1.10.510.10 118 342 4.7E-41 T 09-03-2017 TK78_RS15745 05d717955a8ceffd32bc6a7e3477c481 570 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 21 43 - T 09-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 TK78_RS15745 05d717955a8ceffd32bc6a7e3477c481 570 SMART SM00220 15 290 3.0E-40 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS15745 05d717955a8ceffd32bc6a7e3477c481 570 SUPERFAMILY SSF56112 12 374 4.32E-60 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS15745 05d717955a8ceffd32bc6a7e3477c481 570 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 144 156 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS15745 05d717955a8ceffd32bc6a7e3477c481 570 Pfam PF00069 Protein kinase domain 15 278 9.9E-37 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS20910 5083fb56ff9ab374f9d54b618e373b20 191 TIGRFAM TIGR00177 molyb_syn: molybdenum cofactor synthesis domain 32 168 2.9E-30 T 09-03-2017 IPR001453 MoaB/Mog domain TK78_RS20910 5083fb56ff9ab374f9d54b618e373b20 191 ProSitePatterns PS01078 Molybdenum cofactor biosynthesis proteins signature 1. 91 104 - T 09-03-2017 IPR008284 Molybdenum cofactor biosynthesis, conserved site GO:0006777 Reactome: R-HSA-947581 TK78_RS20910 5083fb56ff9ab374f9d54b618e373b20 191 SUPERFAMILY SSF53218 30 180 1.31E-39 T 09-03-2017 IPR001453 MoaB/Mog domain TK78_RS20910 5083fb56ff9ab374f9d54b618e373b20 191 Gene3D G3DSA:3.40.980.10 29 181 6.8E-50 T 09-03-2017 IPR001453 MoaB/Mog domain TK78_RS20910 5083fb56ff9ab374f9d54b618e373b20 191 Pfam PF00994 Probable molybdopterin binding domain 34 169 2.6E-27 T 09-03-2017 IPR001453 MoaB/Mog domain TK78_RS20910 5083fb56ff9ab374f9d54b618e373b20 191 SMART SM00852 33 175 2.2E-21 T 09-03-2017 IPR001453 MoaB/Mog domain TK78_RS07900 1efc77827c913c075207b74c7dd1ae75 529 Pfam PF13556 PucR C-terminal helix-turn-helix domain 459 517 8.0E-23 T 09-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain TK78_RS07900 1efc77827c913c075207b74c7dd1ae75 529 Pfam PF07905 Purine catabolism regulatory protein-like family 8 126 7.7E-32 T 09-03-2017 IPR012914 Purine catabolism PurC-like domain TK78_RS34475 9151f0f739f28e889b2d7eac36f2f0f2 136 TIGRFAM TIGR03561 organ_hyd_perox: peroxiredoxin, Ohr subfamily 5 134 2.3E-47 T 09-03-2017 IPR019953 Organic hydroperoxide resistance protein famiy GO:0006979 TK78_RS34475 9151f0f739f28e889b2d7eac36f2f0f2 136 Pfam PF02566 OsmC-like protein 37 133 2.0E-18 T 09-03-2017 IPR003718 OsmC/Ohr family TK78_RS34475 9151f0f739f28e889b2d7eac36f2f0f2 136 SUPERFAMILY SSF82784 1 135 9.42E-40 T 09-03-2017 IPR003718 OsmC/Ohr family TK78_RS34475 9151f0f739f28e889b2d7eac36f2f0f2 136 Gene3D G3DSA:2.20.25.10 1 43 2.9E-17 T 09-03-2017 TK78_RS34475 9151f0f739f28e889b2d7eac36f2f0f2 136 Gene3D G3DSA:3.30.300.20 44 135 1.1E-33 T 09-03-2017 IPR015946 K homology domain-like, alpha/beta TK78_RS05270 cf65426d32bc5607ec8d706627e73509 199 Gene3D G3DSA:1.10.150.120 119 195 1.1E-32 T 09-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 TK78_RS05270 cf65426d32bc5607ec8d706627e73509 199 Pfam PF01799 [2Fe-2S] binding domain 121 186 3.9E-28 T 09-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 TK78_RS05270 cf65426d32bc5607ec8d706627e73509 199 SUPERFAMILY SSF54292 2 79 4.46E-21 T 09-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 TK78_RS05270 cf65426d32bc5607ec8d706627e73509 199 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 40 48 - T 09-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 TK78_RS05270 cf65426d32bc5607ec8d706627e73509 199 Gene3D G3DSA:3.10.20.30 2 77 1.1E-26 T 09-03-2017 IPR012675 Beta-grasp domain TK78_RS05270 cf65426d32bc5607ec8d706627e73509 199 SUPERFAMILY SSF47741 124 193 5.1E-30 T 09-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 TK78_RS05270 cf65426d32bc5607ec8d706627e73509 199 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 5 54 5.5E-7 T 09-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 TK78_RS25780 58ec0b8d8dd323b60856fcc80341bf6b 392 Gene3D G3DSA:3.40.47.10 6 125 3.2E-54 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS25780 58ec0b8d8dd323b60856fcc80341bf6b 392 Gene3D G3DSA:3.40.47.10 185 272 3.2E-54 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS25780 58ec0b8d8dd323b60856fcc80341bf6b 392 SUPERFAMILY SSF53901 5 266 4.01E-59 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS25780 58ec0b8d8dd323b60856fcc80341bf6b 392 PIRSF PIRSF000429 1 392 3.8E-113 T 09-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 TK78_RS25780 58ec0b8d8dd323b60856fcc80341bf6b 392 Pfam PF00108 Thiolase, N-terminal domain 6 257 1.0E-50 T 09-03-2017 IPR020616 Thiolase, N-terminal GO:0008152|GO:0016747 TK78_RS25780 58ec0b8d8dd323b60856fcc80341bf6b 392 Pfam PF02803 Thiolase, C-terminal domain 266 391 1.0E-40 T 09-03-2017 IPR020617 Thiolase, C-terminal GO:0008152|GO:0016747 TK78_RS25780 58ec0b8d8dd323b60856fcc80341bf6b 392 ProSitePatterns PS00737 Thiolases signature 2. 338 354 - T 09-03-2017 IPR020613 Thiolase, conserved site GO:0008152|GO:0016747 TK78_RS25780 58ec0b8d8dd323b60856fcc80341bf6b 392 TIGRFAM TIGR01930 AcCoA-C-Actrans: acetyl-CoA C-acyltransferase 7 390 5.2E-115 T 09-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 TK78_RS25780 58ec0b8d8dd323b60856fcc80341bf6b 392 Gene3D G3DSA:3.40.47.10 149 184 8.3E-48 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS25780 58ec0b8d8dd323b60856fcc80341bf6b 392 Gene3D G3DSA:3.40.47.10 273 391 8.3E-48 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS25780 58ec0b8d8dd323b60856fcc80341bf6b 392 SUPERFAMILY SSF53901 267 391 8.83E-39 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS25780 58ec0b8d8dd323b60856fcc80341bf6b 392 ProSitePatterns PS00099 Thiolases active site. 373 386 - T 09-03-2017 IPR020610 Thiolase, active site GO:0008152|GO:0016747 TK78_RS07575 e987018a3c78b5b73d4d4f5139c92731 169 Gene3D G3DSA:3.90.950.20 3 154 7.8E-58 T 09-03-2017 IPR008136 CinA, C-terminal TK78_RS07575 e987018a3c78b5b73d4d4f5139c92731 169 TIGRFAM TIGR00199 PncC_domain: amidohydrolase, PncC family 10 154 2.5E-38 T 09-03-2017 IPR008136 CinA, C-terminal TK78_RS07575 e987018a3c78b5b73d4d4f5139c92731 169 SUPERFAMILY SSF142433 3 154 6.93E-47 T 09-03-2017 IPR008136 CinA, C-terminal TK78_RS07575 e987018a3c78b5b73d4d4f5139c92731 169 Pfam PF02464 Competence-damaged protein 4 153 2.6E-50 T 09-03-2017 IPR008136 CinA, C-terminal TK78_RS34455 027962c26e0600d44b48a2a1738641a1 632 Gene3D G3DSA:2.80.10.50 492 571 2.2E-24 T 09-03-2017 TK78_RS34455 027962c26e0600d44b48a2a1738641a1 632 SMART SM00458 490 631 9.3E-11 T 09-03-2017 IPR000772 Ricin B, lectin domain TK78_RS34455 027962c26e0600d44b48a2a1738641a1 632 SUPERFAMILY SSF50370 489 631 2.34E-38 T 09-03-2017 IPR000772 Ricin B, lectin domain TK78_RS34455 027962c26e0600d44b48a2a1738641a1 632 Pfam PF02055 Glycosyl hydrolase family 30 TIM-barrel domain 84 408 8.8E-37 T 09-03-2017 IPR033453 Glycosyl hydrolase family 30, TIM-barrel domain Reactome: R-HSA-1660662|Reactome: R-HSA-390471 TK78_RS34455 027962c26e0600d44b48a2a1738641a1 632 Gene3D G3DSA:2.60.40.1180 406 474 1.6E-16 T 09-03-2017 IPR013780 Glycosyl hydrolase, all-beta TK78_RS34455 027962c26e0600d44b48a2a1738641a1 632 SUPERFAMILY SSF51445 82 412 3.72E-70 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS34455 027962c26e0600d44b48a2a1738641a1 632 Pfam PF17189 Glycosyl hydrolase family 30 beta sandwich domain 411 472 1.8E-13 T 09-03-2017 IPR033452 Glycosyl hydrolase family 30, beta sandwich domain Reactome: R-HSA-1660662|Reactome: R-HSA-390471 TK78_RS34455 027962c26e0600d44b48a2a1738641a1 632 Pfam PF14200 Ricin-type beta-trefoil lectin domain-like 493 570 3.0E-18 T 09-03-2017 IPR000772 Ricin B, lectin domain TK78_RS34455 027962c26e0600d44b48a2a1738641a1 632 Pfam PF14200 Ricin-type beta-trefoil lectin domain-like 577 631 3.0E-11 T 09-03-2017 IPR000772 Ricin B, lectin domain TK78_RS34455 027962c26e0600d44b48a2a1738641a1 632 SUPERFAMILY SSF51011 406 474 8.63E-9 T 09-03-2017 TK78_RS34455 027962c26e0600d44b48a2a1738641a1 632 Gene3D G3DSA:2.80.10.50 572 630 9.4E-12 T 09-03-2017 TK78_RS34455 027962c26e0600d44b48a2a1738641a1 632 Gene3D G3DSA:3.20.20.80 63 405 3.7E-112 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS10865 8fec9e290d19a33fbecc956978a35de0 604 SUPERFAMILY SSF52540 359 585 1.23E-48 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10865 8fec9e290d19a33fbecc956978a35de0 604 Gene3D G3DSA:3.40.50.300 361 586 2.5E-48 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10865 8fec9e290d19a33fbecc956978a35de0 604 Gene3D G3DSA:1.20.1560.10 26 306 8.3E-14 T 09-03-2017 TK78_RS10865 8fec9e290d19a33fbecc956978a35de0 604 ProSitePatterns PS00211 ABC transporters family signature. 492 506 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS10865 8fec9e290d19a33fbecc956978a35de0 604 Pfam PF00005 ABC transporter 377 520 2.4E-25 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS10865 8fec9e290d19a33fbecc956978a35de0 604 SMART SM00382 386 564 3.8E-14 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS10865 8fec9e290d19a33fbecc956978a35de0 604 SUPERFAMILY SSF90123 23 311 1.7E-21 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS21165 e2ddd625e0b5154b273463bb26f548f8 372 SUPERFAMILY SSF56601 18 367 1.5E-50 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS21165 e2ddd625e0b5154b273463bb26f548f8 372 Pfam PF00144 Beta-lactamase 28 355 2.8E-45 T 09-03-2017 IPR001466 Beta-lactamase-related TK78_RS21165 e2ddd625e0b5154b273463bb26f548f8 372 Gene3D G3DSA:3.40.710.10 31 353 1.1E-53 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS04625 399b7ea62808c983d33186f0a99d1e6b 474 Pfam PF00512 His Kinase A (phospho-acceptor) domain 245 311 8.7E-15 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS04625 399b7ea62808c983d33186f0a99d1e6b 474 SUPERFAMILY SSF55874 301 462 1.01E-35 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS04625 399b7ea62808c983d33186f0a99d1e6b 474 Gene3D G3DSA:1.10.287.130 235 300 8.8E-16 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS04625 399b7ea62808c983d33186f0a99d1e6b 474 Gene3D G3DSA:3.30.565.10 301 462 2.7E-35 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS04625 399b7ea62808c983d33186f0a99d1e6b 474 SUPERFAMILY SSF158472 189 242 9.68E-5 T 09-03-2017 TK78_RS04625 399b7ea62808c983d33186f0a99d1e6b 474 SMART SM00387 356 466 4.2E-32 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS04625 399b7ea62808c983d33186f0a99d1e6b 474 SMART SM00388 245 312 3.1E-15 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS04625 399b7ea62808c983d33186f0a99d1e6b 474 PRINTS PR00344 Bacterial sensor protein C-terminal signature 393 407 1.8E-12 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS04625 399b7ea62808c983d33186f0a99d1e6b 474 PRINTS PR00344 Bacterial sensor protein C-terminal signature 411 421 1.8E-12 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS04625 399b7ea62808c983d33186f0a99d1e6b 474 PRINTS PR00344 Bacterial sensor protein C-terminal signature 426 444 1.8E-12 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS04625 399b7ea62808c983d33186f0a99d1e6b 474 PRINTS PR00344 Bacterial sensor protein C-terminal signature 450 463 1.8E-12 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS04625 399b7ea62808c983d33186f0a99d1e6b 474 Pfam PF00672 HAMP domain 168 240 6.9E-15 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS04625 399b7ea62808c983d33186f0a99d1e6b 474 SUPERFAMILY SSF47384 228 310 7.65E-16 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS04625 399b7ea62808c983d33186f0a99d1e6b 474 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 357 462 2.8E-20 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS04625 399b7ea62808c983d33186f0a99d1e6b 474 SMART SM00304 186 244 1.9E-10 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 SMART SM00231 43 172 0.22 T 09-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 SMART SM00231 176 312 1.0E-19 T 09-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 Pfam PF07705 CARDB 644 744 9.0E-21 T 09-03-2017 IPR011635 CARDB domain TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 Pfam PF07705 CARDB 757 861 1.9E-6 T 09-03-2017 IPR011635 CARDB domain TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 Gene3D G3DSA:2.60.120.260 494 643 3.4E-23 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 Gene3D G3DSA:2.60.120.260 176 315 7.5E-34 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 Gene3D G3DSA:2.60.120.260 35 173 4.6E-23 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 SUPERFAMILY SSF49785 38 169 2.69E-17 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 Gene3D G3DSA:2.60.40.10 318 402 6.5E-15 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 Gene3D G3DSA:2.60.40.10 411 493 1.2E-12 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 SUPERFAMILY SSF49785 176 312 1.21E-27 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 SUPERFAMILY SSF49785 502 639 1.28E-18 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 SMART SM00710 1394 1415 9300.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 SMART SM00710 1220 1248 7300.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 SMART SM00710 1194 1216 1500.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 SMART SM00710 1249 1272 250.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 SMART SM00710 1319 1341 980.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 SMART SM00710 1352 1382 2900.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 SMART SM00710 1170 1192 19.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 SMART SM00060 320 394 0.074 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 SMART SM00060 413 486 11.0 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 Pfam PF00754 F5/8 type C domain 186 306 2.7E-22 T 09-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 Pfam PF00754 F5/8 type C domain 46 166 4.4E-15 T 09-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 Pfam PF00754 F5/8 type C domain 510 633 1.1E-7 T 09-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 SUPERFAMILY SSF51126 1046 1367 2.84E-25 T 09-03-2017 IPR011050 Pectin lyase fold/virulence factor TK78_RS04440 56148579a61b805608c0f1d91eb90fd3 1423 SUPERFAMILY SSF49265 319 491 2.62E-6 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS24495 8ce054efabe1dea19e803eba32849edb 372 Gene3D G3DSA:3.90.1150.10 246 368 2.7E-34 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS24495 8ce054efabe1dea19e803eba32849edb 372 Gene3D G3DSA:3.40.640.10 9 243 1.5E-80 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS24495 8ce054efabe1dea19e803eba32849edb 372 SUPERFAMILY SSF53383 9 367 4.98E-108 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS24495 8ce054efabe1dea19e803eba32849edb 372 Pfam PF01041 DegT/DnrJ/EryC1/StrS aminotransferase family 16 365 6.8E-122 T 09-03-2017 IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase TK78_RS24495 8ce054efabe1dea19e803eba32849edb 372 PIRSF PIRSF000390 5 371 7.2E-113 T 09-03-2017 IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase TK78_RS28385 1c7edd48768c9a01cb246aa38ef9d5ef 339 ProSitePatterns PS01305 moaA / nifB / pqqE family signature. 27 38 - T 09-03-2017 IPR000385 MoaA/nifB/pqqE, iron-sulphur binding, conserved site GO:0003824|GO:0046872|GO:0051539 KEGG: 00790+4.1.99.18|MetaCyc: PWY-6823|Reactome: R-HSA-947581 TK78_RS28385 1c7edd48768c9a01cb246aa38ef9d5ef 339 Hamap MF_01225_B Cyclic pyranopterin monophosphate synthase [moaA]. 12 339 40.667 T 09-03-2017 IPR013483 Molybdenum cofactor biosynthesis protein A GO:0006777|GO:0046872 KEGG: 00790+4.1.99.18|MetaCyc: PWY-6823|Reactome: R-HSA-947581 TK78_RS28385 1c7edd48768c9a01cb246aa38ef9d5ef 339 Pfam PF06463 Molybdenum Cofactor Synthesis C 193 319 2.4E-37 T 09-03-2017 IPR010505 Molybdenum cofactor synthesis C-terminal GO:0006777|GO:0019008|GO:0051539 KEGG: 00790+4.1.99.18|MetaCyc: PWY-6823|Reactome: R-HSA-947581 TK78_RS28385 1c7edd48768c9a01cb246aa38ef9d5ef 339 SUPERFAMILY SSF102114 13 292 1.24E-72 T 09-03-2017 TK78_RS28385 1c7edd48768c9a01cb246aa38ef9d5ef 339 Pfam PF04055 Radical SAM superfamily 26 187 4.7E-35 T 09-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 TK78_RS28385 1c7edd48768c9a01cb246aa38ef9d5ef 339 Pfam PF13353 4Fe-4S single cluster domain 28 117 2.9E-7 T 09-03-2017 TK78_RS28385 1c7edd48768c9a01cb246aa38ef9d5ef 339 TIGRFAM TIGR02666 moaA: molybdenum cofactor biosynthesis protein A 12 339 3.6E-110 T 09-03-2017 IPR013483 Molybdenum cofactor biosynthesis protein A GO:0006777|GO:0046872 KEGG: 00790+4.1.99.18|MetaCyc: PWY-6823|Reactome: R-HSA-947581 TK78_RS28385 1c7edd48768c9a01cb246aa38ef9d5ef 339 SMART SM00729 21 223 6.0E-12 T 09-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 TK78_RS28385 1c7edd48768c9a01cb246aa38ef9d5ef 339 Gene3D G3DSA:3.20.20.70 12 316 1.2E-79 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS26365 9d0e056cf76beed4b34f8027255684e6 339 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 130 329 2.0E-22 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS26365 9d0e056cf76beed4b34f8027255684e6 339 SUPERFAMILY SSF161098 99 326 6.15E-64 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS26365 9d0e056cf76beed4b34f8027255684e6 339 Gene3D G3DSA:1.10.3720.10 105 334 2.7E-66 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS28605 88bb9b051f39b21b1a48766c9ff18969 365 Pfam PF13579 Glycosyl transferase 4-like domain 16 157 4.8E-21 T 09-03-2017 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 TK78_RS28605 88bb9b051f39b21b1a48766c9ff18969 365 SUPERFAMILY SSF53756 16 355 3.14E-58 T 09-03-2017 TK78_RS28605 88bb9b051f39b21b1a48766c9ff18969 365 Gene3D G3DSA:3.40.50.2000 174 332 1.4E-21 T 09-03-2017 TK78_RS28605 88bb9b051f39b21b1a48766c9ff18969 365 Pfam PF00534 Glycosyl transferases group 1 182 332 1.2E-21 T 09-03-2017 IPR001296 Glycosyl transferase, family 1 TK78_RS11440 b5cfb8b439a468d1b28523dd61e3e2e6 517 Pfam PF00652 Ricin-type beta-trefoil lectin domain 395 516 4.5E-22 T 09-03-2017 IPR000772 Ricin B, lectin domain TK78_RS11440 b5cfb8b439a468d1b28523dd61e3e2e6 517 Gene3D G3DSA:3.40.50.1110 84 363 2.2E-39 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS11440 b5cfb8b439a468d1b28523dd61e3e2e6 517 SUPERFAMILY SSF52266 85 366 1.12E-51 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS11440 b5cfb8b439a468d1b28523dd61e3e2e6 517 Gene3D G3DSA:2.80.10.50 396 516 1.9E-26 T 09-03-2017 TK78_RS11440 b5cfb8b439a468d1b28523dd61e3e2e6 517 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 89 356 1.5E-13 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS11440 b5cfb8b439a468d1b28523dd61e3e2e6 517 SUPERFAMILY SSF50370 394 516 2.6E-29 T 09-03-2017 IPR000772 Ricin B, lectin domain TK78_RS11440 b5cfb8b439a468d1b28523dd61e3e2e6 517 SMART SM00458 391 517 1.6E-19 T 09-03-2017 IPR000772 Ricin B, lectin domain TK78_RS24195 de8b999b30c652f3232eab3f87bf8605 302 SUPERFAMILY SSF46785 5 113 8.11E-18 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS24195 de8b999b30c652f3232eab3f87bf8605 302 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 7 64 4.0E-14 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS24195 de8b999b30c652f3232eab3f87bf8605 302 SUPERFAMILY SSF53850 91 300 3.52E-31 T 09-03-2017 TK78_RS24195 de8b999b30c652f3232eab3f87bf8605 302 Gene3D G3DSA:3.40.190.10 184 271 7.5E-28 T 09-03-2017 TK78_RS24195 de8b999b30c652f3232eab3f87bf8605 302 Gene3D G3DSA:1.10.10.10 5 86 9.8E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS24195 de8b999b30c652f3232eab3f87bf8605 302 Pfam PF03466 LysR substrate binding domain 91 298 1.3E-35 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS24195 de8b999b30c652f3232eab3f87bf8605 302 Gene3D G3DSA:3.40.190.10 91 183 8.3E-16 T 09-03-2017 TK78_RS32485 e49542210a662daf892e9c8017b803a0 454 Gene3D G3DSA:3.10.20.70 11 122 6.0E-10 T 09-03-2017 IPR008147 Glutamine synthetase, beta-Grasp domain GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 TK78_RS32485 e49542210a662daf892e9c8017b803a0 454 SUPERFAMILY SSF55931 122 452 1.77E-102 T 09-03-2017 TK78_RS32485 e49542210a662daf892e9c8017b803a0 454 SMART SM01230 120 372 1.8E-102 T 09-03-2017 IPR008146 Glutamine synthetase, catalytic domain GO:0004356|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 TK78_RS32485 e49542210a662daf892e9c8017b803a0 454 Pfam PF00120 Glutamine synthetase, catalytic domain 122 449 8.4E-104 T 09-03-2017 IPR008146 Glutamine synthetase, catalytic domain GO:0004356|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 TK78_RS32485 e49542210a662daf892e9c8017b803a0 454 Gene3D G3DSA:3.30.590.10 123 441 2.8E-100 T 09-03-2017 IPR014746 Glutamine synthetase/guanido kinase, catalytic domain GO:0003824 TK78_RS32485 e49542210a662daf892e9c8017b803a0 454 SUPERFAMILY SSF54368 11 119 8.24E-18 T 09-03-2017 IPR008147 Glutamine synthetase, beta-Grasp domain GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 TK78_RS30135 133277e0866ed90310c3a142dc62ac61 360 TIGRFAM TIGR00916 2A0604s01: protein-export membrane protein, SecD/SecF family 54 292 2.4E-50 T 09-03-2017 IPR022645 Protein-export membrane protein SecD/SecF, bacterial TK78_RS30135 133277e0866ed90310c3a142dc62ac61 360 Hamap MF_01464_B Protein-export membrane protein SecF [secF]. 18 306 23.573 T 09-03-2017 IPR005665 Protein-export membrane protein SecF, bacterial GO:0006886|GO:0015450 TK78_RS30135 133277e0866ed90310c3a142dc62ac61 360 Pfam PF02355 Protein export membrane protein 116 304 5.1E-66 T 09-03-2017 IPR022813 Protein-export membrane protein SecD/SecF, archaeal and bacterial TK78_RS30135 133277e0866ed90310c3a142dc62ac61 360 TIGRFAM TIGR00966 3a0501s07: protein-export membrane protein SecF 46 295 8.8E-75 T 09-03-2017 IPR005665 Protein-export membrane protein SecF, bacterial GO:0006886|GO:0015450 TK78_RS30135 133277e0866ed90310c3a142dc62ac61 360 SUPERFAMILY SSF82866 127 305 6.02E-28 T 09-03-2017 TK78_RS30135 133277e0866ed90310c3a142dc62ac61 360 PRINTS PR01755 Bacterial translocase SecF protein signature 238 253 4.5E-21 T 09-03-2017 IPR022645 Protein-export membrane protein SecD/SecF, bacterial TK78_RS30135 133277e0866ed90310c3a142dc62ac61 360 PRINTS PR01755 Bacterial translocase SecF protein signature 45 60 4.5E-21 T 09-03-2017 IPR022645 Protein-export membrane protein SecD/SecF, bacterial TK78_RS30135 133277e0866ed90310c3a142dc62ac61 360 PRINTS PR01755 Bacterial translocase SecF protein signature 155 169 4.5E-21 T 09-03-2017 IPR022645 Protein-export membrane protein SecD/SecF, bacterial TK78_RS30135 133277e0866ed90310c3a142dc62ac61 360 PRINTS PR01755 Bacterial translocase SecF protein signature 203 221 4.5E-21 T 09-03-2017 IPR022645 Protein-export membrane protein SecD/SecF, bacterial TK78_RS30135 133277e0866ed90310c3a142dc62ac61 360 Gene3D G3DSA:1.20.1640.10 106 310 6.5E-20 T 09-03-2017 TK78_RS10285 505ed3b4f57404d288f727119c20c15f 287 SUPERFAMILY SSF161098 15 287 6.65E-75 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS10285 505ed3b4f57404d288f727119c20c15f 287 Gene3D G3DSA:1.10.3720.10 13 274 3.1E-70 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS10285 505ed3b4f57404d288f727119c20c15f 287 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 99 276 6.8E-21 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS17220 ec8c10cbe06871e07d30b4351fac0c9d 78 ProDom PD002239 RIBOSOMAL S18 RIBONUCLEOPROTEIN 30S RRNA-BINDING RNA-BINDING CHLOROPLAST PLASTID MITOCHONDRIAL ACETYLATION 23 73 3.0E-24 T 09-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS17220 ec8c10cbe06871e07d30b4351fac0c9d 78 Hamap MF_00270 30S ribosomal protein S18 [rpsR]. 3 76 20.663 T 09-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS17220 ec8c10cbe06871e07d30b4351fac0c9d 78 Pfam PF01084 Ribosomal protein S18 21 71 7.6E-24 T 09-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS17220 ec8c10cbe06871e07d30b4351fac0c9d 78 TIGRFAM TIGR00165 S18: ribosomal protein bS18 9 75 5.0E-30 T 09-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS17220 ec8c10cbe06871e07d30b4351fac0c9d 78 SUPERFAMILY SSF46911 5 75 5.49E-28 T 09-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS17220 ec8c10cbe06871e07d30b4351fac0c9d 78 Gene3D G3DSA:4.10.640.10 11 75 7.5E-32 T 09-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS17220 ec8c10cbe06871e07d30b4351fac0c9d 78 PRINTS PR00974 Ribosomal protein S18 family signature 63 73 8.4E-16 T 09-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS17220 ec8c10cbe06871e07d30b4351fac0c9d 78 PRINTS PR00974 Ribosomal protein S18 family signature 31 41 8.4E-16 T 09-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS17220 ec8c10cbe06871e07d30b4351fac0c9d 78 PRINTS PR00974 Ribosomal protein S18 family signature 41 48 8.4E-16 T 09-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS17220 ec8c10cbe06871e07d30b4351fac0c9d 78 PRINTS PR00974 Ribosomal protein S18 family signature 49 63 8.4E-16 T 09-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS17220 ec8c10cbe06871e07d30b4351fac0c9d 78 ProSitePatterns PS00057 Ribosomal protein S18 signature. 24 47 - T 09-03-2017 IPR018275 Ribosomal protein S18, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS29915 337a89d4c0582f8719e212858eb0039e 412 TIGRFAM TIGR02467 CbiE: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit 11 196 2.0E-37 T 09-03-2017 IPR012818 Cobalamin (vitamin B12) biosynthesis CbiE, precorrin-6Y methyltransferase GO:0008276|GO:0009236 TK78_RS29915 337a89d4c0582f8719e212858eb0039e 412 Gene3D G3DSA:3.40.50.150 254 378 2.7E-15 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS29915 337a89d4c0582f8719e212858eb0039e 412 SUPERFAMILY SSF53335 246 385 7.64E-18 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS29915 337a89d4c0582f8719e212858eb0039e 412 SUPERFAMILY SSF53790 8 197 4.71E-31 T 09-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS29915 337a89d4c0582f8719e212858eb0039e 412 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 19 182 7.3E-18 T 09-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS29915 337a89d4c0582f8719e212858eb0039e 412 Gene3D G3DSA:3.40.1010.10 5 103 2.3E-13 T 09-03-2017 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS29915 337a89d4c0582f8719e212858eb0039e 412 Gene3D G3DSA:3.30.950.10 104 198 2.1E-18 T 09-03-2017 IPR014776 Tetrapyrrole methylase, subdomain 2 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS29915 337a89d4c0582f8719e212858eb0039e 412 Pfam PF06325 Ribosomal protein L11 methyltransferase (PrmA) 263 306 6.9E-5 T 09-03-2017 TK78_RS29915 337a89d4c0582f8719e212858eb0039e 412 PIRSF PIRSF036428 1 409 5.2E-86 T 09-03-2017 IPR006365 Cobalamin (vitamin B12) biosynthesis CobL/Precorrin-6Y C(5,15)-methyltransferase GO:0008276|GO:0009236 KEGG: 00270+2.1.1.13|KEGG: 00450+2.1.1.13|KEGG: 00670+2.1.1.13|KEGG: 00860+2.1.1.132|MetaCyc: PWY-2201|MetaCyc: PWY-3841 TK78_RS32785 3cb848f4b84972281d5cac7911c660a2 235 SUPERFAMILY SSF46689 8 80 8.29E-15 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS32785 3cb848f4b84972281d5cac7911c660a2 235 Pfam PF00440 Bacterial regulatory proteins, tetR family 21 65 2.2E-11 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS32785 3cb848f4b84972281d5cac7911c660a2 235 Gene3D G3DSA:1.10.357.10 2 218 3.6E-40 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS32785 3cb848f4b84972281d5cac7911c660a2 235 SUPERFAMILY SSF48498 93 225 1.71E-31 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS32785 3cb848f4b84972281d5cac7911c660a2 235 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 19 32 2.9E-5 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS32785 3cb848f4b84972281d5cac7911c660a2 235 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 40 63 2.9E-5 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS33815 75e012f23505cd4041ed0f9ab9cd3542 379 Gene3D G3DSA:2.40.50.140 17 70 2.1E-14 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS33815 75e012f23505cd4041ed0f9ab9cd3542 379 SMART SM00382 126 311 1.4E-6 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS33815 75e012f23505cd4041ed0f9ab9cd3542 379 Hamap MF_01884 Transcription termination factor Rho [rho]. 1 375 159.985 T 09-03-2017 IPR004665 Transcription termination factor Rho GO:0003723|GO:0005524|GO:0006353|GO:0008186 TK78_RS33815 75e012f23505cd4041ed0f9ab9cd3542 379 Pfam PF07497 Rho termination factor, RNA-binding domain 19 83 8.8E-13 T 09-03-2017 IPR011113 Rho termination factor, RNA-binding GO:0003723|GO:0006353 TK78_RS33815 75e012f23505cd4041ed0f9ab9cd3542 379 SUPERFAMILY SSF50249 16 84 1.88E-8 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS33815 75e012f23505cd4041ed0f9ab9cd3542 379 Pfam PF00006 ATP synthase alpha/beta family, nucleotide-binding domain 116 319 1.1E-18 T 09-03-2017 IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain GO:0005524 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 TK78_RS33815 75e012f23505cd4041ed0f9ab9cd3542 379 SUPERFAMILY SSF52540 77 327 2.0E-57 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33815 75e012f23505cd4041ed0f9ab9cd3542 379 Gene3D G3DSA:3.40.50.300 92 372 1.2E-82 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09020 a5db2392ff5b7a1570b845b409c33697 209 Gene3D G3DSA:1.20.140.10 82 135 8.6E-5 T 09-03-2017 TK78_RS09020 a5db2392ff5b7a1570b845b409c33697 209 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 80 139 1.9E-4 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS09020 a5db2392ff5b7a1570b845b409c33697 209 SUPERFAMILY SSF47203 80 197 8.72E-8 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS11605 7d5ee114ce7584c7bf69fa0b752ae0c3 315 SUPERFAMILY SSF46894 242 304 1.84E-18 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS11605 7d5ee114ce7584c7bf69fa0b752ae0c3 315 Pfam PF00196 Bacterial regulatory proteins, luxR family 249 301 2.6E-18 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS11605 7d5ee114ce7584c7bf69fa0b752ae0c3 315 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 249 263 3.4E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS11605 7d5ee114ce7584c7bf69fa0b752ae0c3 315 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 263 279 3.4E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS11605 7d5ee114ce7584c7bf69fa0b752ae0c3 315 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 279 291 3.4E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS11605 7d5ee114ce7584c7bf69fa0b752ae0c3 315 Gene3D G3DSA:3.40.50.2300 52 169 5.3E-30 T 09-03-2017 TK78_RS11605 7d5ee114ce7584c7bf69fa0b752ae0c3 315 Gene3D G3DSA:3.40.50.2300 239 252 5.3E-30 T 09-03-2017 TK78_RS11605 7d5ee114ce7584c7bf69fa0b752ae0c3 315 SUPERFAMILY SSF52172 53 172 6.12E-27 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS11605 7d5ee114ce7584c7bf69fa0b752ae0c3 315 SMART SM00421 246 303 4.9E-21 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS11605 7d5ee114ce7584c7bf69fa0b752ae0c3 315 SMART SM00448 54 165 3.3E-23 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS11605 7d5ee114ce7584c7bf69fa0b752ae0c3 315 ProSitePatterns PS00622 LuxR-type HTH domain signature. 263 290 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS11605 7d5ee114ce7584c7bf69fa0b752ae0c3 315 Gene3D G3DSA:1.10.10.10 253 301 4.6E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS11605 7d5ee114ce7584c7bf69fa0b752ae0c3 315 Gene3D G3DSA:1.10.10.10 170 192 4.6E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS11605 7d5ee114ce7584c7bf69fa0b752ae0c3 315 Pfam PF00072 Response regulator receiver domain 56 165 5.1E-21 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS23050 87ceb331e4d2aa0f0acebf4b04eee624 550 ProSitePatterns PS00455 Putative AMP-binding domain signature. 161 172 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS23050 87ceb331e4d2aa0f0acebf4b04eee624 550 Gene3D G3DSA:2.30.38.10 319 405 3.6E-22 T 09-03-2017 TK78_RS23050 87ceb331e4d2aa0f0acebf4b04eee624 550 Gene3D G3DSA:3.30.300.30 411 510 2.9E-15 T 09-03-2017 TK78_RS23050 87ceb331e4d2aa0f0acebf4b04eee624 550 Pfam PF00501 AMP-binding enzyme 18 414 1.8E-63 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS23050 87ceb331e4d2aa0f0acebf4b04eee624 550 Gene3D G3DSA:3.40.50.980 18 166 2.0E-16 T 09-03-2017 TK78_RS23050 87ceb331e4d2aa0f0acebf4b04eee624 550 Pfam PF13193 AMP-binding enzyme C-terminal domain 425 501 2.2E-9 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS23050 87ceb331e4d2aa0f0acebf4b04eee624 550 Gene3D G3DSA:3.40.50.980 167 318 3.2E-22 T 09-03-2017 TK78_RS23050 87ceb331e4d2aa0f0acebf4b04eee624 550 SUPERFAMILY SSF56801 16 513 3.53E-103 T 09-03-2017 TK78_RS08665 d3d59c721659825d780dc510179a557e 324 SUPERFAMILY SSF53822 61 323 6.67E-68 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS08665 d3d59c721659825d780dc510179a557e 324 Gene3D G3DSA:3.40.50.2300 169 322 9.5E-54 T 09-03-2017 TK78_RS08665 d3d59c721659825d780dc510179a557e 324 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 4 14 1.1E-6 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS08665 d3d59c721659825d780dc510179a557e 324 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 14 24 1.1E-6 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS08665 d3d59c721659825d780dc510179a557e 324 ProSitePatterns PS00356 LacI-type HTH domain signature. 5 23 - T 09-03-2017 TK78_RS08665 d3d59c721659825d780dc510179a557e 324 Pfam PF13377 Periplasmic binding protein-like domain 169 322 1.4E-34 T 09-03-2017 TK78_RS08665 d3d59c721659825d780dc510179a557e 324 Gene3D G3DSA:3.40.50.2300 62 168 1.2E-22 T 09-03-2017 TK78_RS08665 d3d59c721659825d780dc510179a557e 324 Gene3D G3DSA:1.10.260.40 3 61 2.0E-22 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS08665 d3d59c721659825d780dc510179a557e 324 SUPERFAMILY SSF47413 2 60 2.16E-15 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS08665 d3d59c721659825d780dc510179a557e 324 SMART SM00354 2 72 1.2E-25 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS08665 d3d59c721659825d780dc510179a557e 324 Pfam PF00356 Bacterial regulatory proteins, lacI family 4 49 2.9E-17 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS19860 6b1e3b9f2b43e95d0ad8fddfe2f45874 470 SMART SM00382 91 245 1.6E-7 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS19860 6b1e3b9f2b43e95d0ad8fddfe2f45874 470 Pfam PF13481 AAA domain 84 223 6.6E-16 T 09-03-2017 TK78_RS19860 6b1e3b9f2b43e95d0ad8fddfe2f45874 470 Pfam PF13541 Subunit ChlI of Mg-chelatase 371 430 2.7E-8 T 09-03-2017 TK78_RS19860 6b1e3b9f2b43e95d0ad8fddfe2f45874 470 Gene3D G3DSA:3.30.230.10 285 454 2.1E-30 T 09-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TK78_RS19860 6b1e3b9f2b43e95d0ad8fddfe2f45874 470 Gene3D G3DSA:3.40.50.300 70 276 1.1E-44 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS19860 6b1e3b9f2b43e95d0ad8fddfe2f45874 470 PRINTS PR01874 DNA repair protein radA signature 175 199 9.5E-85 T 09-03-2017 TK78_RS19860 6b1e3b9f2b43e95d0ad8fddfe2f45874 470 PRINTS PR01874 DNA repair protein radA signature 249 275 9.5E-85 T 09-03-2017 TK78_RS19860 6b1e3b9f2b43e95d0ad8fddfe2f45874 470 PRINTS PR01874 DNA repair protein radA signature 16 40 9.5E-85 T 09-03-2017 TK78_RS19860 6b1e3b9f2b43e95d0ad8fddfe2f45874 470 PRINTS PR01874 DNA repair protein radA signature 214 242 9.5E-85 T 09-03-2017 TK78_RS19860 6b1e3b9f2b43e95d0ad8fddfe2f45874 470 PRINTS PR01874 DNA repair protein radA signature 323 346 9.5E-85 T 09-03-2017 TK78_RS19860 6b1e3b9f2b43e95d0ad8fddfe2f45874 470 PRINTS PR01874 DNA repair protein radA signature 83 111 9.5E-85 T 09-03-2017 TK78_RS19860 6b1e3b9f2b43e95d0ad8fddfe2f45874 470 PRINTS PR01874 DNA repair protein radA signature 125 142 9.5E-85 T 09-03-2017 TK78_RS19860 6b1e3b9f2b43e95d0ad8fddfe2f45874 470 SUPERFAMILY SSF52540 72 292 2.51E-46 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS19860 6b1e3b9f2b43e95d0ad8fddfe2f45874 470 TIGRFAM TIGR00416 sms: DNA repair protein RadA 8 451 7.3E-154 T 09-03-2017 IPR004504 DNA repair protein RadA GO:0003684|GO:0005524|GO:0006281 TK78_RS19860 6b1e3b9f2b43e95d0ad8fddfe2f45874 470 Hamap MF_01498 DNA repair protein RadA [radA]. 27 455 42.025 T 09-03-2017 IPR004504 DNA repair protein RadA GO:0003684|GO:0005524|GO:0006281 TK78_RS19860 6b1e3b9f2b43e95d0ad8fddfe2f45874 470 SUPERFAMILY SSF54211 294 454 8.34E-34 T 09-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold TK78_RS31970 b766ea2d2579bd4dab60905a024a0295 308 SUPERFAMILY SSF160104 70 220 9.94E-16 T 09-03-2017 TK78_RS31970 b766ea2d2579bd4dab60905a024a0295 308 Pfam PF06314 Acetoacetate decarboxylase (ADC) 75 283 1.7E-13 T 09-03-2017 IPR010451 Acetoacetate decarboxylase GO:0016829 KEGG: 00072+4.1.1.4|KEGG: 00640+4.1.1.4|MetaCyc: PWY-5451|MetaCyc: PWY-6588|MetaCyc: PWY-6876|MetaCyc: PWY-7466 TK78_RS31970 b766ea2d2579bd4dab60905a024a0295 308 Gene3D G3DSA:2.40.400.10 81 216 4.5E-11 T 09-03-2017 IPR023375 Acetoacetate decarboxylase beta barrel domain KEGG: 00072+4.1.1.4|KEGG: 00640+4.1.1.4|MetaCyc: PWY-5451|MetaCyc: PWY-6588|MetaCyc: PWY-6876|MetaCyc: PWY-7466 TK78_RS34750 5e5a199a94edb941878cbee400b8e2ec 230 PIRSF PIRSF036625 1 230 1.5E-78 T 09-03-2017 IPR012074 GAF-ANTAR transcription anti-termination regulator, putative TK78_RS34750 5e5a199a94edb941878cbee400b8e2ec 230 SUPERFAMILY SSF52172 162 220 1.24E-8 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS34750 5e5a199a94edb941878cbee400b8e2ec 230 SMART SM01012 167 222 4.9E-18 T 09-03-2017 IPR005561 ANTAR domain GO:0003723 TK78_RS34750 5e5a199a94edb941878cbee400b8e2ec 230 Gene3D G3DSA:1.10.10.10 173 228 8.8E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS34750 5e5a199a94edb941878cbee400b8e2ec 230 SUPERFAMILY SSF55781 23 174 3.49E-18 T 09-03-2017 IPR029016 GAF domain-like TK78_RS34750 5e5a199a94edb941878cbee400b8e2ec 230 Gene3D G3DSA:3.30.450.40 14 172 1.3E-20 T 09-03-2017 IPR029016 GAF domain-like TK78_RS34750 5e5a199a94edb941878cbee400b8e2ec 230 Pfam PF03861 ANTAR domain 169 218 3.9E-19 T 09-03-2017 IPR005561 ANTAR domain GO:0003723 TK78_RS34750 5e5a199a94edb941878cbee400b8e2ec 230 SMART SM00065 22 172 0.0052 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS34750 5e5a199a94edb941878cbee400b8e2ec 230 Pfam PF13185 GAF domain 22 162 6.6E-11 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS34015 51cd4bfe7b0064ab7a67b06063409154 272 Pfam PF04231 Endonuclease I 57 266 2.7E-43 T 09-03-2017 IPR007346 Endonuclease I GO:0004518 TK78_RS34015 51cd4bfe7b0064ab7a67b06063409154 272 SUPERFAMILY SSF54060 55 266 5.41E-58 T 09-03-2017 TK78_RS28070 6ecd6b7bab7bdf9dce3f9632fcc922fb 412 Gene3D G3DSA:2.60.60.30 248 401 7.1E-49 T 09-03-2017 TK78_RS28070 6ecd6b7bab7bdf9dce3f9632fcc922fb 412 Gene3D G3DSA:2.60.60.30 23 159 2.2E-26 T 09-03-2017 TK78_RS28070 6ecd6b7bab7bdf9dce3f9632fcc922fb 412 Pfam PF02342 TerD domain 23 161 3.3E-27 T 09-03-2017 IPR003325 TerD domain GO:0006950 TK78_RS28070 6ecd6b7bab7bdf9dce3f9632fcc922fb 412 Pfam PF02342 TerD domain 230 398 1.8E-39 T 09-03-2017 IPR003325 TerD domain GO:0006950 TK78_RS16085 7fc3fc8d54d77dc078061b3705ac6073 396 TIGRFAM TIGR02349 DnaJ_bact: chaperone protein DnaJ 10 379 5.1E-119 T 09-03-2017 IPR012724 Chaperone DnaJ GO:0005524|GO:0006457|GO:0009408|GO:0051082 TK78_RS16085 7fc3fc8d54d77dc078061b3705ac6073 396 SUPERFAMILY SSF46565 9 112 4.58E-30 T 09-03-2017 IPR001623 DnaJ domain TK78_RS16085 7fc3fc8d54d77dc078061b3705ac6073 396 Pfam PF01556 DnaJ C terminal domain 149 362 1.1E-34 T 09-03-2017 IPR002939 Chaperone DnaJ, C-terminal TK78_RS16085 7fc3fc8d54d77dc078061b3705ac6073 396 SUPERFAMILY SSF49493 288 373 9.81E-20 T 09-03-2017 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 TK78_RS16085 7fc3fc8d54d77dc078061b3705ac6073 396 Pfam PF00684 DnaJ central domain 176 236 2.4E-9 T 09-03-2017 IPR001305 Heat shock protein DnaJ, cysteine-rich domain GO:0031072|GO:0051082 TK78_RS16085 7fc3fc8d54d77dc078061b3705ac6073 396 Gene3D G3DSA:1.10.287.110 4 99 3.2E-31 T 09-03-2017 IPR001623 DnaJ domain TK78_RS16085 7fc3fc8d54d77dc078061b3705ac6073 396 ProSitePatterns PS00636 Nt-dnaJ domain signature. 52 71 - T 09-03-2017 IPR018253 DnaJ domain, conserved site TK78_RS16085 7fc3fc8d54d77dc078061b3705ac6073 396 Gene3D G3DSA:2.60.260.20 124 170 3.3E-20 T 09-03-2017 TK78_RS16085 7fc3fc8d54d77dc078061b3705ac6073 396 Gene3D G3DSA:2.60.260.20 239 282 3.3E-20 T 09-03-2017 TK78_RS16085 7fc3fc8d54d77dc078061b3705ac6073 396 SUPERFAMILY SSF49493 143 197 7.33E-19 T 09-03-2017 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 TK78_RS16085 7fc3fc8d54d77dc078061b3705ac6073 396 SUPERFAMILY SSF49493 242 295 7.33E-19 T 09-03-2017 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 TK78_RS16085 7fc3fc8d54d77dc078061b3705ac6073 396 Hamap MF_01152 Chaperone protein DnaJ [dnaJ]. 7 396 37.223 T 09-03-2017 IPR012724 Chaperone DnaJ GO:0005524|GO:0006457|GO:0009408|GO:0051082 TK78_RS16085 7fc3fc8d54d77dc078061b3705ac6073 396 SUPERFAMILY SSF57938 163 238 1.12E-13 T 09-03-2017 IPR001305 Heat shock protein DnaJ, cysteine-rich domain GO:0031072|GO:0051082 TK78_RS16085 7fc3fc8d54d77dc078061b3705ac6073 396 Gene3D G3DSA:2.10.230.10 171 238 1.7E-15 T 09-03-2017 IPR001305 Heat shock protein DnaJ, cysteine-rich domain GO:0031072|GO:0051082 TK78_RS16085 7fc3fc8d54d77dc078061b3705ac6073 396 SMART SM00271 9 67 9.7E-29 T 09-03-2017 IPR001623 DnaJ domain TK78_RS16085 7fc3fc8d54d77dc078061b3705ac6073 396 PRINTS PR00625 DnaJ domain signature 47 67 4.4E-23 T 09-03-2017 IPR001623 DnaJ domain TK78_RS16085 7fc3fc8d54d77dc078061b3705ac6073 396 PRINTS PR00625 DnaJ domain signature 67 86 4.4E-23 T 09-03-2017 IPR001623 DnaJ domain TK78_RS16085 7fc3fc8d54d77dc078061b3705ac6073 396 PRINTS PR00625 DnaJ domain signature 12 30 4.4E-23 T 09-03-2017 IPR001623 DnaJ domain TK78_RS16085 7fc3fc8d54d77dc078061b3705ac6073 396 PRINTS PR00625 DnaJ domain signature 30 45 4.4E-23 T 09-03-2017 IPR001623 DnaJ domain TK78_RS16085 7fc3fc8d54d77dc078061b3705ac6073 396 Pfam PF00226 DnaJ domain 10 72 5.1E-26 T 09-03-2017 IPR001623 DnaJ domain TK78_RS16085 7fc3fc8d54d77dc078061b3705ac6073 396 Gene3D G3DSA:2.60.260.20 285 363 1.1E-19 T 09-03-2017 TK78_RS15675 e7a34cc79bd3774e653870c43b8540b7 356 PIRSF PIRSF000148 5 354 5.1E-103 T 09-03-2017 IPR012080 Aspartate-semialdehyde dehydrogenase GO:0004073|GO:0009086|GO:0009088|GO:0009089|GO:0009097|GO:0050661|GO:0055114 KEGG: 00260+1.2.1.11|KEGG: 00261+1.2.1.11|KEGG: 00270+1.2.1.11|KEGG: 00300+1.2.1.11|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153 TK78_RS15675 e7a34cc79bd3774e653870c43b8540b7 356 Pfam PF02774 Semialdehyde dehydrogenase, dimerisation domain 143 337 6.8E-39 T 09-03-2017 IPR012280 Semialdehyde dehydrogenase, dimerisation domain GO:0003942|GO:0005737|GO:0008652|GO:0016620|GO:0046983|GO:0055114 KEGG: 00220+1.2.1.38|MetaCyc: PWY-5154|MetaCyc: PWY-7400 TK78_RS15675 e7a34cc79bd3774e653870c43b8540b7 356 Pfam PF01118 Semialdehyde dehydrogenase, NAD binding domain 8 119 1.4E-26 T 09-03-2017 IPR000534 Semialdehyde dehydrogenase, NAD-binding GO:0016620|GO:0051287|GO:0055114 TK78_RS15675 e7a34cc79bd3774e653870c43b8540b7 356 TIGRFAM TIGR01296 asd_B: aspartate-semialdehyde dehydrogenase 8 351 4.2E-101 T 09-03-2017 IPR005986 Aspartate-semialdehyde dehydrogenase, beta-type GO:0004073|GO:0009086|GO:0009088|GO:0009089|GO:0009097|GO:0050661|GO:0055114 KEGG: 00260+1.2.1.11|KEGG: 00261+1.2.1.11|KEGG: 00270+1.2.1.11|KEGG: 00300+1.2.1.11|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153 TK78_RS15675 e7a34cc79bd3774e653870c43b8540b7 356 SUPERFAMILY SSF51735 8 159 1.13E-41 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS15675 e7a34cc79bd3774e653870c43b8540b7 356 Gene3D G3DSA:3.30.360.10 145 333 2.3E-62 T 09-03-2017 TK78_RS15675 e7a34cc79bd3774e653870c43b8540b7 356 SMART SM00859 7 122 7.6E-30 T 09-03-2017 IPR000534 Semialdehyde dehydrogenase, NAD-binding GO:0016620|GO:0051287|GO:0055114 TK78_RS15675 e7a34cc79bd3774e653870c43b8540b7 356 SUPERFAMILY SSF55347 131 338 3.27E-56 T 09-03-2017 TK78_RS15675 e7a34cc79bd3774e653870c43b8540b7 356 Gene3D G3DSA:3.40.50.720 7 144 6.2E-50 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 SMART SM00823 Phosphopantetheine attachment site 3973 4042 5.3E-6 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 SMART SM00823 Phosphopantetheine attachment site 380 449 5.0E-11 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 SMART SM00823 Phosphopantetheine attachment site 2914 2983 3.7E-5 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 SMART SM00823 Phosphopantetheine attachment site 1859 1928 9.8E-9 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 971 1368 2.5E-123 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 5 294 2.5E-99 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 2433 2830 9.5E-126 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 3486 3889 8.5E-128 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 SUPERFAMILY SSF52777 3185 3430 8.23E-56 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Pfam PF00668 Condensation domain 2997 3296 1.2E-59 T 09-03-2017 IPR001242 Condensation domain TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Pfam PF00668 Condensation domain 463 762 1.3E-64 T 09-03-2017 IPR001242 Condensation domain TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Pfam PF00668 Condensation domain 1941 2241 1.8E-64 T 09-03-2017 IPR001242 Condensation domain TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 SMART SM00824 Thioesterase 4067 4275 0.0059 T 09-03-2017 IPR020802 Polyketide synthase, thioesterase domain GO:0009058|GO:0016788 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Gene3D G3DSA:2.30.38.10 1256 1333 2.1E-24 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Gene3D G3DSA:2.30.38.10 183 260 6.7E-28 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Gene3D G3DSA:2.30.38.10 3778 3854 3.2E-25 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Gene3D G3DSA:2.30.38.10 2718 2796 9.4E-27 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 SUPERFAMILY SSF52777 466 638 2.22E-48 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 SUPERFAMILY SSF52777 650 902 1.22E-62 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 SUPERFAMILY SSF56801 5 393 5.23E-119 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Gene3D G3DSA:3.40.50.980 942 1096 2.6E-43 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Gene3D G3DSA:1.10.1200.10 1865 1926 7.3E-27 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Gene3D G3DSA:1.10.1200.10 2918 2979 6.5E-25 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Gene3D G3DSA:1.10.1200.10 3978 4041 3.4E-26 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Gene3D G3DSA:1.10.1200.10 385 447 2.1E-26 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 SUPERFAMILY SSF56801 3457 3986 2.35E-152 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 SUPERFAMILY SSF52777 2129 2376 7.45E-58 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Gene3D G3DSA:3.40.50.980 39 182 9.6E-36 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Gene3D G3DSA:3.40.50.980 3640 3777 3.8E-39 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Gene3D G3DSA:3.40.50.150 1444 1567 2.1E-19 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 SUPERFAMILY SSF47336 374 446 3.14E-20 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 SUPERFAMILY SSF47336 3967 4038 3.53E-19 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 ProSitePatterns PS00455 Putative AMP-binding domain signature. 17 28 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Pfam PF00501 AMP-binding enzyme 956 1344 9.5E-91 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Pfam PF00501 AMP-binding enzyme 2412 2806 2.4E-88 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Pfam PF00501 AMP-binding enzyme 9 270 2.1E-68 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Pfam PF00501 AMP-binding enzyme 3465 3864 3.8E-94 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Pfam PF13745 HxxPF-repeated domain 784 879 2.6E-28 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Pfam PF13745 HxxPF-repeated domain 3318 3412 5.2E-27 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Pfam PF13745 HxxPF-repeated domain 2266 2359 1.4E-25 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Gene3D G3DSA:3.40.50.980 3459 3639 1.1E-46 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Gene3D G3DSA:3.40.50.980 6 38 2.7E-9 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Gene3D G3DSA:3.30.300.30 1339 1396 1.6E-35 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Gene3D G3DSA:3.30.300.30 3860 3977 1.1E-38 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Gene3D G3DSA:3.30.300.30 2801 2917 1.1E-39 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Gene3D G3DSA:3.30.300.30 1801 1864 1.6E-35 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Gene3D G3DSA:3.30.300.30 266 384 5.2E-43 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1883 1898 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Pfam PF00975 Thioesterase domain 4066 4166 9.6E-23 T 09-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 SUPERFAMILY SSF56801 1796 1872 4.71E-141 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 SUPERFAMILY SSF56801 939 1398 4.71E-141 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Pfam PF00550 Phosphopantetheine attachment site 3975 4038 1.5E-14 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Pfam PF00550 Phosphopantetheine attachment site 1861 1924 3.2E-16 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Pfam PF00550 Phosphopantetheine attachment site 383 444 2.2E-15 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Pfam PF00550 Phosphopantetheine attachment site 2917 2977 1.3E-13 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3997 4012 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 SUPERFAMILY SSF53474 4050 4277 4.02E-50 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 SUPERFAMILY SSF52777 3000 3172 5.23E-46 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Pfam PF13193 AMP-binding enzyme C-terminal domain 3873 3948 3.0E-13 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Pfam PF13193 AMP-binding enzyme C-terminal domain 2814 2889 2.7E-13 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Pfam PF13193 AMP-binding enzyme C-terminal domain 278 354 1.9E-15 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Gene3D G3DSA:3.40.50.1820 4214 4279 2.0E-43 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Gene3D G3DSA:3.40.50.1820 4051 4168 2.0E-43 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 SUPERFAMILY SSF53335 1426 1573 1.74E-22 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 ProSitePatterns PS00455 Putative AMP-binding domain signature. 1090 1101 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Pfam PF08242 Methyltransferase domain 1463 1558 7.4E-10 T 09-03-2017 IPR013217 Methyltransferase type 12 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 SUPERFAMILY SSF52777 1945 2117 5.56E-49 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 ProSitePatterns PS00012 Phosphopantetheine attachment site. 404 419 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 SUPERFAMILY SSF56801 2373 2927 8.5E-148 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 ProSitePatterns PS00455 Putative AMP-binding domain signature. 2559 2570 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Gene3D G3DSA:3.40.50.980 2408 2565 2.3E-45 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 SUPERFAMILY SSF47336 1854 1924 2.62E-20 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Gene3D G3DSA:3.40.50.980 2566 2717 4.8E-27 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 Gene3D G3DSA:3.40.50.980 1097 1255 1.4E-32 T 09-03-2017 TK78_RS06760 87c8d81bb934c65323dd6e67c093d820 4299 SUPERFAMILY SSF47336 2907 2979 2.62E-19 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS26760 51fbfff0614ed07db979d23645d1beda 578 ProSitePatterns PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 264 318 - T 09-03-2017 IPR023615 Cytochrome c oxidase, subunit I, copper-binding site GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS26760 51fbfff0614ed07db979d23645d1beda 578 SUPERFAMILY SSF81442 31 542 8.63E-175 T 09-03-2017 IPR023616 Cytochrome c oxidase, subunit I domain GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS26760 51fbfff0614ed07db979d23645d1beda 578 Pfam PF00115 Cytochrome C and Quinol oxidase polypeptide I 44 486 6.7E-145 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS26760 51fbfff0614ed07db979d23645d1beda 578 PRINTS PR01165 Cytochrome c oxidase subunit I signature 34 59 3.5E-103 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS26760 51fbfff0614ed07db979d23645d1beda 578 PRINTS PR01165 Cytochrome c oxidase subunit I signature 212 231 3.5E-103 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS26760 51fbfff0614ed07db979d23645d1beda 578 PRINTS PR01165 Cytochrome c oxidase subunit I signature 151 163 3.5E-103 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS26760 51fbfff0614ed07db979d23645d1beda 578 PRINTS PR01165 Cytochrome c oxidase subunit I signature 108 132 3.5E-103 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS26760 51fbfff0614ed07db979d23645d1beda 578 PRINTS PR01165 Cytochrome c oxidase subunit I signature 308 323 3.5E-103 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS26760 51fbfff0614ed07db979d23645d1beda 578 PRINTS PR01165 Cytochrome c oxidase subunit I signature 365 383 3.5E-103 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS26760 51fbfff0614ed07db979d23645d1beda 578 PRINTS PR01165 Cytochrome c oxidase subunit I signature 393 412 3.5E-103 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS26760 51fbfff0614ed07db979d23645d1beda 578 PRINTS PR01165 Cytochrome c oxidase subunit I signature 330 351 3.5E-103 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS26760 51fbfff0614ed07db979d23645d1beda 578 PRINTS PR01165 Cytochrome c oxidase subunit I signature 241 262 3.5E-103 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS26760 51fbfff0614ed07db979d23645d1beda 578 PRINTS PR01165 Cytochrome c oxidase subunit I signature 183 201 3.5E-103 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS26760 51fbfff0614ed07db979d23645d1beda 578 PRINTS PR01165 Cytochrome c oxidase subunit I signature 443 464 3.5E-103 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS26760 51fbfff0614ed07db979d23645d1beda 578 PRINTS PR01165 Cytochrome c oxidase subunit I signature 81 104 3.5E-103 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS26760 51fbfff0614ed07db979d23645d1beda 578 PRINTS PR01165 Cytochrome c oxidase subunit I signature 262 283 3.5E-103 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS26760 51fbfff0614ed07db979d23645d1beda 578 TIGRFAM TIGR02891 CtaD_CoxA: cytochrome c oxidase, subunit I 35 539 3.1E-213 T 09-03-2017 IPR014241 Cytochrome c oxidase, subunit I bacterial type GO:0004129|GO:0005507|GO:0005886|GO:0006810|GO:0022900|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279 TK78_RS26760 51fbfff0614ed07db979d23645d1beda 578 Gene3D G3DSA:1.20.210.10 27 554 4.1E-193 T 09-03-2017 IPR023616 Cytochrome c oxidase, subunit I domain GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS22540 30011ff1b0339afec4908bb1056e3192 455 Gene3D G3DSA:1.10.45.10 415 454 2.4E-13 T 09-03-2017 IPR016171 Vanillyl-alcohol oxidase, C-terminal subdomain 2 TK78_RS22540 30011ff1b0339afec4908bb1056e3192 455 Gene3D G3DSA:3.30.465.10 96 216 1.4E-43 T 09-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 TK78_RS22540 30011ff1b0339afec4908bb1056e3192 455 Gene3D G3DSA:3.30.43.10 2 95 2.2E-26 T 09-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 TK78_RS22540 30011ff1b0339afec4908bb1056e3192 455 SUPERFAMILY SSF55103 191 454 3.92E-60 T 09-03-2017 IPR016164 FAD-linked oxidase-like, C-terminal GO:0003824|GO:0050660 TK78_RS22540 30011ff1b0339afec4908bb1056e3192 455 Pfam PF01565 FAD binding domain 40 179 1.5E-39 T 09-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 TK78_RS22540 30011ff1b0339afec4908bb1056e3192 455 Pfam PF02913 FAD linked oxidases, C-terminal domain 216 454 8.8E-66 T 09-03-2017 IPR004113 FAD-linked oxidase, C-terminal GO:0003824|GO:0050660 TK78_RS22540 30011ff1b0339afec4908bb1056e3192 455 SUPERFAMILY SSF56176 1 216 9.81E-71 T 09-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 TK78_RS13740 4e8c98f62b97f51b46a54cecb1e605de 219 Gene3D G3DSA:3.20.20.140 90 152 0.001 T 09-03-2017 TK78_RS13740 4e8c98f62b97f51b46a54cecb1e605de 219 Gene3D G3DSA:2.30.40.10 176 215 2.6E-5 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS13740 4e8c98f62b97f51b46a54cecb1e605de 219 Gene3D G3DSA:2.30.40.10 3 59 2.6E-5 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS13740 4e8c98f62b97f51b46a54cecb1e605de 219 SUPERFAMILY SSF51338 3 60 1.93E-13 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS22155 f6f22ef617961f13803f82fdc34e75f5 263 Gene3D G3DSA:3.40.50.300 14 255 3.7E-42 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22155 f6f22ef617961f13803f82fdc34e75f5 263 SUPERFAMILY SSF52540 54 256 1.7E-39 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22155 f6f22ef617961f13803f82fdc34e75f5 263 SMART SM00382 68 251 2.8E-14 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS22155 f6f22ef617961f13803f82fdc34e75f5 263 Pfam PF00005 ABC transporter 60 193 1.3E-16 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS19185 e9102ca2d273f8a7ea454474817047d7 427 Pfam PF05977 Transmembrane secretion effector 22 420 7.6E-36 T 09-03-2017 IPR010290 Transmembrane secretion effector TK78_RS19185 e9102ca2d273f8a7ea454474817047d7 427 Gene3D G3DSA:1.20.1250.20 239 414 6.4E-12 T 09-03-2017 TK78_RS19185 e9102ca2d273f8a7ea454474817047d7 427 Gene3D G3DSA:1.20.1250.20 16 210 5.6E-18 T 09-03-2017 TK78_RS19185 e9102ca2d273f8a7ea454474817047d7 427 SUPERFAMILY SSF103473 22 419 5.89E-47 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS02510 d65b197af5b3158434795db988fa3115 511 ProSitePatterns PS00122 Carboxylesterases type-B serine active site. 176 191 - T 09-03-2017 IPR019826 Carboxylesterase type B, active site TK78_RS02510 d65b197af5b3158434795db988fa3115 511 Gene3D G3DSA:3.40.50.1820 4 460 2.9E-111 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS02510 d65b197af5b3158434795db988fa3115 511 SUPERFAMILY SSF53474 5 465 7.61E-99 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS02510 d65b197af5b3158434795db988fa3115 511 Pfam PF00135 Carboxylesterase family 3 460 2.7E-88 T 09-03-2017 IPR002018 Carboxylesterase, type B TK78_RS22415 62df5cefccd7f3b90b708fb278195559 787 Gene3D G3DSA:3.30.365.10 473 607 3.9E-22 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS22415 62df5cefccd7f3b90b708fb278195559 787 SUPERFAMILY SSF54665 40 162 1.2E-39 T 09-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead TK78_RS22415 62df5cefccd7f3b90b708fb278195559 787 SMART SM01008 55 161 4.9E-44 T 09-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead TK78_RS22415 62df5cefccd7f3b90b708fb278195559 787 Gene3D G3DSA:3.30.365.10 379 413 3.3E-41 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS22415 62df5cefccd7f3b90b708fb278195559 787 Gene3D G3DSA:3.30.365.10 622 780 3.3E-41 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS22415 62df5cefccd7f3b90b708fb278195559 787 Gene3D G3DSA:3.30.365.10 150 201 1.2E-30 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS22415 62df5cefccd7f3b90b708fb278195559 787 Gene3D G3DSA:3.30.365.10 305 378 1.2E-30 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS22415 62df5cefccd7f3b90b708fb278195559 787 Gene3D G3DSA:3.30.365.10 202 303 2.0E-20 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS22415 62df5cefccd7f3b90b708fb278195559 787 Gene3D G3DSA:3.90.1170.50 39 149 4.3E-40 T 09-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead TK78_RS22415 62df5cefccd7f3b90b708fb278195559 787 Pfam PF01315 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain 56 160 1.2E-27 T 09-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead TK78_RS22415 62df5cefccd7f3b90b708fb278195559 787 SUPERFAMILY SSF56003 162 782 7.85E-123 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS22415 62df5cefccd7f3b90b708fb278195559 787 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 183 724 8.1E-111 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS11905 dc1b1775dfad3af8fb2980952ca1f902 304 PRINTS PR00111 Alpha/beta hydrolase fold signature 130 143 2.6E-6 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS11905 dc1b1775dfad3af8fb2980952ca1f902 304 PRINTS PR00111 Alpha/beta hydrolase fold signature 116 129 2.6E-6 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS11905 dc1b1775dfad3af8fb2980952ca1f902 304 PRINTS PR00111 Alpha/beta hydrolase fold signature 240 254 2.6E-6 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS11905 dc1b1775dfad3af8fb2980952ca1f902 304 Gene3D G3DSA:3.40.50.1820 7 293 5.8E-57 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS11905 dc1b1775dfad3af8fb2980952ca1f902 304 Pfam PF08386 TAP-like protein 237 292 4.6E-5 T 09-03-2017 IPR013595 Peptidase S33 tripeptidyl aminopeptidase-like, C-terminal TK78_RS11905 dc1b1775dfad3af8fb2980952ca1f902 304 SUPERFAMILY SSF53474 10 292 1.04E-48 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS11905 dc1b1775dfad3af8fb2980952ca1f902 304 Pfam PF00561 alpha/beta hydrolase fold 29 146 6.9E-19 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS22660 0f705748d27b72cd0effb8ff50127ca7 245 Hamap MF_00564 Ribonuclease PH [rph]. 2 240 47.885 T 09-03-2017 IPR002381 Ribonuclease phosphorolytic, bacterial-type GO:0000049|GO:0004549|GO:0008033 TK78_RS22660 0f705748d27b72cd0effb8ff50127ca7 245 TIGRFAM TIGR01966 RNasePH: ribonuclease PH 3 239 1.8E-116 T 09-03-2017 IPR002381 Ribonuclease phosphorolytic, bacterial-type GO:0000049|GO:0004549|GO:0008033 TK78_RS22660 0f705748d27b72cd0effb8ff50127ca7 245 Pfam PF01138 3' exoribonuclease family, domain 1 11 141 1.6E-24 T 09-03-2017 IPR001247 Exoribonuclease, phosphorolytic domain 1 Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 TK78_RS22660 0f705748d27b72cd0effb8ff50127ca7 245 SUPERFAMILY SSF55666 157 241 6.15E-25 T 09-03-2017 IPR015847 Exoribonuclease, phosphorolytic domain 2 Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 TK78_RS22660 0f705748d27b72cd0effb8ff50127ca7 245 Gene3D G3DSA:3.30.230.70 3 238 2.1E-30 T 09-03-2017 IPR027408 PNPase/RNase PH domain Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 TK78_RS22660 0f705748d27b72cd0effb8ff50127ca7 245 Pfam PF03725 3' exoribonuclease family, domain 2 161 226 9.3E-11 T 09-03-2017 IPR015847 Exoribonuclease, phosphorolytic domain 2 Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 TK78_RS22660 0f705748d27b72cd0effb8ff50127ca7 245 ProSitePatterns PS01277 Ribonuclease PH signature. 117 130 - T 09-03-2017 IPR018336 Ribonuclease PH, conserved site TK78_RS22660 0f705748d27b72cd0effb8ff50127ca7 245 SUPERFAMILY SSF54211 3 183 1.11E-46 T 09-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold TK78_RS29300 6740cdc8e9aa80427814866c02a938a1 532 Gene3D G3DSA:3.90.76.10 50 205 5.2E-30 T 09-03-2017 TK78_RS29300 6740cdc8e9aa80427814866c02a938a1 532 SUPERFAMILY SSF53850 32 522 2.71E-93 T 09-03-2017 TK78_RS29300 6740cdc8e9aa80427814866c02a938a1 532 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 83 449 1.4E-67 T 09-03-2017 IPR000914 Solute-binding protein family 5 domain TK78_RS29300 6740cdc8e9aa80427814866c02a938a1 532 PIRSF PIRSF002741 3 529 9.8E-68 T 09-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 TK78_RS29300 6740cdc8e9aa80427814866c02a938a1 532 Gene3D G3DSA:3.10.105.10 288 499 1.9E-46 T 09-03-2017 TK78_RS30095 042caca1c2a341b06fa85c3b3dbce1bd 306 SUPERFAMILY SSF51366 30 276 3.72E-62 T 09-03-2017 IPR011060 Ribulose-phosphate binding barrel GO:0003824|GO:0008152 TK78_RS30095 042caca1c2a341b06fa85c3b3dbce1bd 306 Pfam PF01680 SOR/SNZ family 19 224 3.6E-106 T 09-03-2017 IPR001852 Pyridoxal 5'-phosphate synthase subunit PdxS/SNZ GO:0042819|GO:0042823 KEGG: 00750+4.3.3.6|MetaCyc: PWY-6466 TK78_RS30095 042caca1c2a341b06fa85c3b3dbce1bd 306 Hamap MF_01824 Pyridoxal 5'-phosphate synthase subunit PdxS [pdxS]. 16 306 51.998 T 09-03-2017 IPR001852 Pyridoxal 5'-phosphate synthase subunit PdxS/SNZ GO:0042819|GO:0042823 KEGG: 00750+4.3.3.6|MetaCyc: PWY-6466 TK78_RS30095 042caca1c2a341b06fa85c3b3dbce1bd 306 ProSitePatterns PS01235 PdxS/SNZ family signature. 217 235 - T 09-03-2017 IPR001852 Pyridoxal 5'-phosphate synthase subunit PdxS/SNZ GO:0042819|GO:0042823 KEGG: 00750+4.3.3.6|MetaCyc: PWY-6466 TK78_RS30095 042caca1c2a341b06fa85c3b3dbce1bd 306 TIGRFAM TIGR00343 TIGR00343: pyridoxal 5'-phosphate synthase, synthase subunit Pdx1 21 306 1.4E-142 T 09-03-2017 IPR001852 Pyridoxal 5'-phosphate synthase subunit PdxS/SNZ GO:0042819|GO:0042823 KEGG: 00750+4.3.3.6|MetaCyc: PWY-6466 TK78_RS30095 042caca1c2a341b06fa85c3b3dbce1bd 306 PIRSF PIRSF029271 7 306 3.9E-150 T 09-03-2017 IPR001852 Pyridoxal 5'-phosphate synthase subunit PdxS/SNZ GO:0042819|GO:0042823 KEGG: 00750+4.3.3.6|MetaCyc: PWY-6466 TK78_RS30095 042caca1c2a341b06fa85c3b3dbce1bd 306 Gene3D G3DSA:3.20.20.70 204 290 2.2E-46 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS30095 042caca1c2a341b06fa85c3b3dbce1bd 306 Gene3D G3DSA:3.20.20.70 36 172 2.2E-46 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS03900 072a0aa650b55ac5582674e6ab6d2244 391 ProSitePatterns PS00730 AP endonucleases family 2 signature 2. 211 218 - T 09-03-2017 IPR018246 AP endonuclease 2, zinc binding site GO:0008270 TK78_RS03900 072a0aa650b55ac5582674e6ab6d2244 391 Gene3D G3DSA:3.20.20.150 49 248 1.6E-20 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS03900 072a0aa650b55ac5582674e6ab6d2244 391 SUPERFAMILY SSF51658 16 251 2.75E-30 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS03900 072a0aa650b55ac5582674e6ab6d2244 391 Pfam PF01261 Xylose isomerase-like TIM barrel 55 236 4.4E-16 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS00155 31f14b021b38e1737a6682e666e365fb 114 Pfam PF12840 Helix-turn-helix domain 10 69 1.6E-12 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS00155 31f14b021b38e1737a6682e666e365fb 114 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 13 28 7.1E-5 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS00155 31f14b021b38e1737a6682e666e365fb 114 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 60 75 7.1E-5 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS00155 31f14b021b38e1737a6682e666e365fb 114 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 45 60 7.1E-5 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS00155 31f14b021b38e1737a6682e666e365fb 114 SUPERFAMILY SSF46785 5 102 1.55E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS00155 31f14b021b38e1737a6682e666e365fb 114 Gene3D G3DSA:1.10.10.10 5 110 3.1E-28 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS00155 31f14b021b38e1737a6682e666e365fb 114 SMART SM00418 11 89 8.2E-14 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS33735 a6cad8eb1c7094bc6b68b93e7ec3a873 578 Gene3D G3DSA:2.60.120.260 173 312 4.1E-30 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS33735 a6cad8eb1c7094bc6b68b93e7ec3a873 578 Gene3D G3DSA:2.60.120.260 31 170 2.8E-29 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS33735 a6cad8eb1c7094bc6b68b93e7ec3a873 578 SUPERFAMILY SSF49785 37 163 3.26E-28 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS33735 a6cad8eb1c7094bc6b68b93e7ec3a873 578 SUPERFAMILY SSF49899 316 578 7.8E-76 T 09-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain TK78_RS33735 a6cad8eb1c7094bc6b68b93e7ec3a873 578 SUPERFAMILY SSF49785 180 308 3.4E-26 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS33735 a6cad8eb1c7094bc6b68b93e7ec3a873 578 Gene3D G3DSA:2.60.120.200 315 578 4.0E-77 T 09-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain TK78_RS33735 a6cad8eb1c7094bc6b68b93e7ec3a873 578 Pfam PF00722 Glycosyl hydrolases family 16 363 575 8.2E-36 T 09-03-2017 IPR000757 Glycoside hydrolase family 16 GO:0004553|GO:0005975 TK78_RS33735 a6cad8eb1c7094bc6b68b93e7ec3a873 578 Pfam PF00754 F5/8 type C domain 47 157 1.4E-23 T 09-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain TK78_RS33735 a6cad8eb1c7094bc6b68b93e7ec3a873 578 Pfam PF00754 F5/8 type C domain 185 303 1.1E-20 T 09-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain TK78_RS30470 23f5d96dfa798f46b346179fd65a6acb 432 Hamap MF_00180 3,4-dihydroxy-2-butanone 4-phosphate synthase [ribB]. 19 223 38.39 T 09-03-2017 IPR000422 3,4-dihydroxy-2-butanone 4-phosphate synthase, RibB GO:0008686|GO:0009231 KEGG: 00740+4.1.99.12|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TK78_RS30470 23f5d96dfa798f46b346179fd65a6acb 432 Pfam PF00926 3,4-dihydroxy-2-butanone 4-phosphate synthase 25 218 2.4E-83 T 09-03-2017 IPR000422 3,4-dihydroxy-2-butanone 4-phosphate synthase, RibB GO:0008686|GO:0009231 KEGG: 00740+4.1.99.12|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TK78_RS30470 23f5d96dfa798f46b346179fd65a6acb 432 Pfam PF00925 GTP cyclohydrolase II 227 393 3.2E-69 T 09-03-2017 IPR032677 GTP cyclohydrolase II KEGG: 00740+3.5.4.25|MetaCyc: PWY-6168|MetaCyc: PWY-7539 TK78_RS30470 23f5d96dfa798f46b346179fd65a6acb 432 TIGRFAM TIGR00506 ribB: 3,4-dihydroxy-2-butanone-4-phosphate synthase 22 219 1.4E-73 T 09-03-2017 IPR000422 3,4-dihydroxy-2-butanone 4-phosphate synthase, RibB GO:0008686|GO:0009231 KEGG: 00740+4.1.99.12|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TK78_RS30470 23f5d96dfa798f46b346179fd65a6acb 432 Hamap MF_00179 GTP cyclohydrolase-2 [ribA]. 224 420 40.684 T 09-03-2017 IPR000926 GTP cyclohydrolase II, RibA GO:0003935|GO:0009231 KEGG: 00740+3.5.4.25|MetaCyc: PWY-6168|MetaCyc: PWY-7539 TK78_RS30470 23f5d96dfa798f46b346179fd65a6acb 432 PIRSF PIRSF001259 20 423 9.6E-175 T 09-03-2017 TK78_RS30470 23f5d96dfa798f46b346179fd65a6acb 432 SUPERFAMILY SSF142695 225 396 2.35E-66 T 09-03-2017 IPR032677 GTP cyclohydrolase II KEGG: 00740+3.5.4.25|MetaCyc: PWY-6168|MetaCyc: PWY-7539 TK78_RS30470 23f5d96dfa798f46b346179fd65a6acb 432 TIGRFAM TIGR00505 ribA: GTP cyclohydrolase II 228 417 1.2E-72 T 09-03-2017 IPR000926 GTP cyclohydrolase II, RibA GO:0003935|GO:0009231 KEGG: 00740+3.5.4.25|MetaCyc: PWY-6168|MetaCyc: PWY-7539 TK78_RS30470 23f5d96dfa798f46b346179fd65a6acb 432 Gene3D G3DSA:3.90.870.10 18 231 1.2E-95 T 09-03-2017 IPR017945 DHBP synthase RibB-like alpha/beta domain TK78_RS30470 23f5d96dfa798f46b346179fd65a6acb 432 Hamap MF_01283 Riboflavin biosynthesis protein RibBA [ribBA]. 20 416 53.291 T 09-03-2017 IPR016299 Riboflavin biosynthesis protein RibBA GO:0009231 KEGG: 00740+3.5.4.25+4.1.99.12|MetaCyc: PWY-6167|MetaCyc: PWY-6168|MetaCyc: PWY-7539 TK78_RS30470 23f5d96dfa798f46b346179fd65a6acb 432 SUPERFAMILY SSF55821 19 222 9.61E-82 T 09-03-2017 IPR017945 DHBP synthase RibB-like alpha/beta domain TK78_RS13195 7f129d17734882ab924a296132329386 397 TIGRFAM TIGR00485 EF-Tu: translation elongation factor Tu 2 397 2.1E-221 T 09-03-2017 IPR004541 Translation elongation factor EFTu/EF1A, bacterial/organelle GO:0003746|GO:0005525|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 TK78_RS13195 7f129d17734882ab924a296132329386 397 Gene3D G3DSA:3.40.50.300 5 213 7.8E-71 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13195 7f129d17734882ab924a296132329386 397 Pfam PF03144 Elongation factor Tu domain 2 227 296 3.5E-17 T 09-03-2017 IPR004161 Translation elongation factor EFTu-like, domain 2 GO:0005525 TK78_RS13195 7f129d17734882ab924a296132329386 397 Hamap MF_00118_B Elongation factor Tu [tuf]. 1 397 59.146 T 09-03-2017 IPR004541 Translation elongation factor EFTu/EF1A, bacterial/organelle GO:0003746|GO:0005525|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 TK78_RS13195 7f129d17734882ab924a296132329386 397 Pfam PF03143 Elongation factor Tu C-terminal domain 301 395 1.2E-32 T 09-03-2017 IPR004160 Translation elongation factor EFTu/EF1A, C-terminal TK78_RS13195 7f129d17734882ab924a296132329386 397 ProSitePatterns PS00301 Translational (tr)-type guanine nucleotide-binding (G) domain signature. 53 68 - T 09-03-2017 IPR031157 Tr-type G domain, conserved site TK78_RS13195 7f129d17734882ab924a296132329386 397 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 13 147 1.9E-13 T 09-03-2017 IPR005225 Small GTP-binding protein domain GO:0005525 TK78_RS13195 7f129d17734882ab924a296132329386 397 PRINTS PR00315 GTP-binding elongation factor signature 133 142 2.3E-24 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS13195 7f129d17734882ab924a296132329386 397 PRINTS PR00315 GTP-binding elongation factor signature 60 68 2.3E-24 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS13195 7f129d17734882ab924a296132329386 397 PRINTS PR00315 GTP-binding elongation factor signature 96 107 2.3E-24 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS13195 7f129d17734882ab924a296132329386 397 PRINTS PR00315 GTP-binding elongation factor signature 14 27 2.3E-24 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS13195 7f129d17734882ab924a296132329386 397 PRINTS PR00315 GTP-binding elongation factor signature 80 90 2.3E-24 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS13195 7f129d17734882ab924a296132329386 397 Pfam PF00009 Elongation factor Tu GTP binding domain 10 203 4.9E-59 T 09-03-2017 TK78_RS13195 7f129d17734882ab924a296132329386 397 SUPERFAMILY SSF50465 305 397 3.45E-35 T 09-03-2017 IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal TK78_RS13195 7f129d17734882ab924a296132329386 397 Gene3D G3DSA:2.40.30.10 303 396 3.7E-45 T 09-03-2017 TK78_RS13195 7f129d17734882ab924a296132329386 397 SUPERFAMILY SSF52540 6 221 8.24E-62 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13195 7f129d17734882ab924a296132329386 397 SUPERFAMILY SSF50447 207 304 8.64E-31 T 09-03-2017 IPR009000 Translation protein, beta-barrel domain TK78_RS13195 7f129d17734882ab924a296132329386 397 Gene3D G3DSA:2.40.30.10 214 301 8.1E-37 T 09-03-2017 TK78_RS33965 9343ea6806e4d000a095621d9191bb9a 186 SUPERFAMILY SSF47741 103 185 7.2E-28 T 09-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 TK78_RS33965 9343ea6806e4d000a095621d9191bb9a 186 Gene3D G3DSA:3.10.20.30 20 93 2.1E-29 T 09-03-2017 IPR012675 Beta-grasp domain TK78_RS33965 9343ea6806e4d000a095621d9191bb9a 186 Pfam PF01799 [2Fe-2S] binding domain 92 181 1.8E-30 T 09-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 TK78_RS33965 9343ea6806e4d000a095621d9191bb9a 186 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 25 78 3.1E-7 T 09-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 TK78_RS33965 9343ea6806e4d000a095621d9191bb9a 186 Gene3D G3DSA:1.10.150.120 94 185 7.3E-32 T 09-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 TK78_RS33965 9343ea6806e4d000a095621d9191bb9a 186 SUPERFAMILY SSF54292 20 107 2.23E-24 T 09-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 TK78_RS33965 9343ea6806e4d000a095621d9191bb9a 186 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 58 66 - T 09-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 TK78_RS29665 d782817e31b0afed50193479da7a4e8a 676 Pfam PF12161 HsdM N-terminal domain 7 137 2.0E-22 T 09-03-2017 IPR022749 N6 adenine-specific DNA methyltransferase, N-terminal domain TK78_RS29665 d782817e31b0afed50193479da7a4e8a 676 SUPERFAMILY SSF53335 5 44 1.33E-118 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS29665 d782817e31b0afed50193479da7a4e8a 676 SUPERFAMILY SSF53335 72 505 1.33E-118 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS29665 d782817e31b0afed50193479da7a4e8a 676 Gene3D G3DSA:3.40.50.150 174 434 2.8E-32 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS29665 d782817e31b0afed50193479da7a4e8a 676 PRINTS PR00507 N12 class N6 adenine-specific DNA methyltransferase signature 205 219 3.7E-13 T 09-03-2017 TK78_RS29665 d782817e31b0afed50193479da7a4e8a 676 PRINTS PR00507 N12 class N6 adenine-specific DNA methyltransferase signature 172 188 3.7E-13 T 09-03-2017 TK78_RS29665 d782817e31b0afed50193479da7a4e8a 676 PRINTS PR00507 N12 class N6 adenine-specific DNA methyltransferase signature 277 289 3.7E-13 T 09-03-2017 TK78_RS29665 d782817e31b0afed50193479da7a4e8a 676 Pfam PF02384 N-6 DNA Methylase 149 453 2.2E-57 T 09-03-2017 IPR003356 DNA methylase, adenine-specific GO:0003677|GO:0006306|GO:0008170 TK78_RS05595 ab1de38b87664b0d23556334e1053940 289 SUPERFAMILY SSF161098 15 288 1.31E-73 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS05595 ab1de38b87664b0d23556334e1053940 289 Gene3D G3DSA:1.10.3720.10 17 276 9.6E-70 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS05595 ab1de38b87664b0d23556334e1053940 289 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 101 278 3.0E-21 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS04575 fc42336a8b66755b8956af38d390de73 500 Gene3D G3DSA:3.40.605.10 4 261 2.5E-88 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS04575 fc42336a8b66755b8956af38d390de73 500 Gene3D G3DSA:3.40.309.10 262 444 3.9E-62 T 09-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 TK78_RS04575 fc42336a8b66755b8956af38d390de73 500 Pfam PF00171 Aldehyde dehydrogenase family 22 479 1.1E-139 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS04575 fc42336a8b66755b8956af38d390de73 500 SUPERFAMILY SSF53720 2 483 9.69E-151 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS04575 fc42336a8b66755b8956af38d390de73 500 TIGRFAM TIGR01722 MMSDH: methylmalonate-semialdehyde dehydrogenase (acylating) 6 483 1.4E-195 T 09-03-2017 IPR010061 Methylmalonate-semialdehyde dehydrogenase GO:0004491|GO:0055114 KEGG: 00280+1.2.1.27|KEGG: 00410+1.2.1.18|KEGG: 00562+1.2.1.18|KEGG: 00640+1.2.1.18+1.2.1.27|MetaCyc: PWY-5642|MetaCyc: PWY-6373|Reactome: R-HSA-70895 TK78_RS04575 fc42336a8b66755b8956af38d390de73 500 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 275 286 - T 09-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 TK78_RS26780 e17638fa2d4c27ef534eb27162e90452 206 Pfam PF00510 Cytochrome c oxidase subunit III 25 204 4.1E-25 T 09-03-2017 IPR000298 Cytochrome c oxidase subunit III domain GO:0015002|GO:0016020 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS26780 e17638fa2d4c27ef534eb27162e90452 206 SUPERFAMILY SSF81452 12 204 4.84E-55 T 09-03-2017 IPR000298 Cytochrome c oxidase subunit III domain GO:0015002|GO:0016020 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS26780 e17638fa2d4c27ef534eb27162e90452 206 Gene3D G3DSA:1.20.120.80 25 205 5.2E-55 T 09-03-2017 IPR013833 Cytochrome c oxidase, subunit III, 4-helical bundle GO:0004129|GO:0016020|GO:0022904 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS20460 d33ecd225d5d5c2ab9e4becaa5966dbd 579 SUPERFAMILY SSF51556 58 315 4.93E-52 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS20460 d33ecd225d5d5c2ab9e4becaa5966dbd 579 SUPERFAMILY SSF51556 371 499 4.93E-52 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS20460 d33ecd225d5d5c2ab9e4becaa5966dbd 579 SUPERFAMILY SSF51338 1 57 1.97E-19 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS20460 d33ecd225d5d5c2ab9e4becaa5966dbd 579 SUPERFAMILY SSF51338 499 562 1.97E-19 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS20460 d33ecd225d5d5c2ab9e4becaa5966dbd 579 Pfam PF07969 Amidohydrolase family 49 544 5.7E-70 T 09-03-2017 IPR013108 Amidohydrolase 3 TK78_RS20460 d33ecd225d5d5c2ab9e4becaa5966dbd 579 Gene3D G3DSA:3.20.20.140 424 484 8.0E-82 T 09-03-2017 TK78_RS20460 d33ecd225d5d5c2ab9e4becaa5966dbd 579 Gene3D G3DSA:3.20.20.140 72 307 8.0E-82 T 09-03-2017 TK78_RS20460 d33ecd225d5d5c2ab9e4becaa5966dbd 579 Gene3D G3DSA:2.30.40.10 485 517 3.5E-10 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS20460 d33ecd225d5d5c2ab9e4becaa5966dbd 579 Gene3D G3DSA:2.30.40.10 1 71 2.1E-16 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS15970 6eb9ae84e3a5aca67326d35f7d7731ab 282 Hamap MF_01972 Tryptophan 2,3-dioxygenase [kynA]. 19 282 36.326 T 09-03-2017 IPR004981 Tryptophan 2,3-dioxygenase GO:0004833|GO:0019441|GO:0020037 KEGG: 00380+1.13.11.11|Reactome: R-HSA-71240 TK78_RS15970 6eb9ae84e3a5aca67326d35f7d7731ab 282 SUPERFAMILY SSF140959 25 281 2.35E-81 T 09-03-2017 TK78_RS15970 6eb9ae84e3a5aca67326d35f7d7731ab 282 Pfam PF03301 Tryptophan 2,3-dioxygenase 13 282 1.6E-77 T 09-03-2017 IPR004981 Tryptophan 2,3-dioxygenase GO:0004833|GO:0019441|GO:0020037 KEGG: 00380+1.13.11.11|Reactome: R-HSA-71240 TK78_RS12955 b9b5faad379a344691fb354fe5ef3c15 469 SMART SM00860 173 320 1.0E-10 T 09-03-2017 IPR018958 SMI1/KNR4-like domain TK78_RS12955 b9b5faad379a344691fb354fe5ef3c15 469 SUPERFAMILY SSF160631 267 321 8.89E-12 T 09-03-2017 TK78_RS12955 b9b5faad379a344691fb354fe5ef3c15 469 SUPERFAMILY SSF160631 173 230 8.89E-12 T 09-03-2017 TK78_RS12955 b9b5faad379a344691fb354fe5ef3c15 469 Pfam PF09346 SMI1 / KNR4 family (SUKH-1) 173 319 5.7E-17 T 09-03-2017 IPR018958 SMI1/KNR4-like domain TK78_RS12955 b9b5faad379a344691fb354fe5ef3c15 469 Gene3D G3DSA:3.40.1580.10 173 323 4.4E-8 T 09-03-2017 IPR018958 SMI1/KNR4-like domain TK78_RS00685 0d569975f96c9d4de14fea98bed6a488 495 Gene3D G3DSA:3.40.720.10 3 266 6.1E-28 T 09-03-2017 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 TK78_RS00685 0d569975f96c9d4de14fea98bed6a488 495 Gene3D G3DSA:3.40.50.1000 369 467 2.2E-37 T 09-03-2017 IPR023214 HAD-like domain TK78_RS00685 0d569975f96c9d4de14fea98bed6a488 495 Gene3D G3DSA:3.40.50.1000 283 297 2.2E-37 T 09-03-2017 IPR023214 HAD-like domain TK78_RS00685 0d569975f96c9d4de14fea98bed6a488 495 Pfam PF13419 Haloacid dehalogenase-like hydrolase 286 464 5.6E-23 T 09-03-2017 IPR023214 HAD-like domain TK78_RS00685 0d569975f96c9d4de14fea98bed6a488 495 SUPERFAMILY SSF53649 4 259 1.08E-33 T 09-03-2017 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 TK78_RS00685 0d569975f96c9d4de14fea98bed6a488 495 SUPERFAMILY SSF56784 284 467 1.33E-41 T 09-03-2017 IPR023214 HAD-like domain TK78_RS00685 0d569975f96c9d4de14fea98bed6a488 495 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 360 462 9.9E-14 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS00685 0d569975f96c9d4de14fea98bed6a488 495 Pfam PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 7 219 3.7E-19 T 09-03-2017 IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase GO:0003824 TK78_RS03150 8bf1b222f152978722d54648108e1b8a 461 Pfam PF01593 Flavin containing amine oxidoreductase 17 445 4.0E-43 T 09-03-2017 IPR002937 Amine oxidase GO:0016491|GO:0055114 TK78_RS03150 8bf1b222f152978722d54648108e1b8a 461 Gene3D G3DSA:3.50.50.60 157 173 2.6E-32 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS03150 8bf1b222f152978722d54648108e1b8a 461 Gene3D G3DSA:3.50.50.60 369 446 2.6E-32 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS03150 8bf1b222f152978722d54648108e1b8a 461 Gene3D G3DSA:3.50.50.60 11 95 2.6E-32 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS03150 8bf1b222f152978722d54648108e1b8a 461 Gene3D G3DSA:3.50.50.60 214 284 2.6E-32 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS03150 8bf1b222f152978722d54648108e1b8a 461 PRINTS PR00757 Flavin-containing amine oxidase signature 9 28 7.6E-5 T 09-03-2017 IPR001613 Flavin amine oxidase GO:0016491|GO:0055114 TK78_RS03150 8bf1b222f152978722d54648108e1b8a 461 PRINTS PR00757 Flavin-containing amine oxidase signature 427 444 7.6E-5 T 09-03-2017 IPR001613 Flavin amine oxidase GO:0016491|GO:0055114 TK78_RS03150 8bf1b222f152978722d54648108e1b8a 461 TIGRFAM TIGR03467 HpnE: squalene-associated FAD-dependent desaturase 11 446 2.9E-139 T 09-03-2017 IPR017830 Squalene-associated FAD-dependent desaturase TK78_RS03150 8bf1b222f152978722d54648108e1b8a 461 SUPERFAMILY SSF51905 11 317 1.39E-52 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS03150 8bf1b222f152978722d54648108e1b8a 461 SUPERFAMILY SSF51905 406 449 1.39E-52 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS26435 f98dbd9bfdcc2b3d3979db7f4f936f8c 181 SUPERFAMILY SSF69118 4 178 4.58E-38 T 09-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 TK78_RS26435 f98dbd9bfdcc2b3d3979db7f4f936f8c 181 Gene3D G3DSA:1.20.1290.10 57 177 3.0E-24 T 09-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 TK78_RS26435 f98dbd9bfdcc2b3d3979db7f4f936f8c 181 Pfam PF02627 Carboxymuconolactone decarboxylase family 54 119 3.0E-6 T 09-03-2017 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 TK78_RS09030 b225ffab8fb1217d8485de5c514cb95b 282 SUPERFAMILY SSF53901 76 186 7.04E-5 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS30835 634e49ab68f79e108ac647d243f96fdb 273 Gene3D G3DSA:3.10.310.10 125 259 1.3E-38 T 09-03-2017 TK78_RS30835 634e49ab68f79e108ac647d243f96fdb 273 PIRSF PIRSF016184 1 271 3.1E-49 T 09-03-2017 IPR003719 Phenazine biosynthesis PhzF protein GO:0003824|GO:0009058 TK78_RS30835 634e49ab68f79e108ac647d243f96fdb 273 Gene3D G3DSA:3.10.310.10 1 122 8.8E-38 T 09-03-2017 TK78_RS30835 634e49ab68f79e108ac647d243f96fdb 273 SUPERFAMILY SSF54506 2 269 2.4E-69 T 09-03-2017 TK78_RS30835 634e49ab68f79e108ac647d243f96fdb 273 TIGRFAM TIGR00654 PhzF_family: phenazine biosynthesis protein, PhzF family 4 229 2.3E-36 T 09-03-2017 IPR003719 Phenazine biosynthesis PhzF protein GO:0003824|GO:0009058 TK78_RS30835 634e49ab68f79e108ac647d243f96fdb 273 Pfam PF02567 Phenazine biosynthesis-like protein 6 267 1.8E-58 T 09-03-2017 IPR003719 Phenazine biosynthesis PhzF protein GO:0003824|GO:0009058 TK78_RS03020 372922c6d8300aa0376f789eb864bf04 170 SUPERFAMILY SSF54427 19 158 1.65E-29 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS03020 372922c6d8300aa0376f789eb864bf04 170 Gene3D G3DSA:3.10.450.50 19 160 2.9E-23 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS03020 372922c6d8300aa0376f789eb864bf04 170 Pfam PF13577 SnoaL-like domain 21 148 2.0E-20 T 09-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain TK78_RS22595 3916c9dc409769abf798df9f7f1c114d 484 ProSitePatterns PS00218 Amino acid permeases signature. 63 93 - T 09-03-2017 IPR004840 Amino acid permease, conserved site GO:0006865|GO:0016021|GO:0055085 TK78_RS22595 3916c9dc409769abf798df9f7f1c114d 484 PIRSF PIRSF006060 24 480 1.8E-59 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS22595 3916c9dc409769abf798df9f7f1c114d 484 Pfam PF00324 Amino acid permease 39 467 4.7E-108 T 09-03-2017 IPR004841 Amino acid permease/ SLC12A domain GO:0006810|GO:0016020|GO:0055085 TK78_RS28600 3b56b6b478e36f1917edc88125c58d29 581 Gene3D G3DSA:3.40.50.300 453 532 1.4E-6 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28600 3b56b6b478e36f1917edc88125c58d29 581 Pfam PF02463 RecF/RecN/SMC N terminal domain 17 532 8.4E-17 T 09-03-2017 IPR003395 RecF/RecN/SMC, N-terminal TK78_RS28600 3b56b6b478e36f1917edc88125c58d29 581 SUPERFAMILY SSF52540 8 52 8.5E-24 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28600 3b56b6b478e36f1917edc88125c58d29 581 SUPERFAMILY SSF52540 364 529 8.5E-24 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28600 3b56b6b478e36f1917edc88125c58d29 581 SUPERFAMILY SSF52540 3 222 2.17E-53 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28600 3b56b6b478e36f1917edc88125c58d29 581 TIGRFAM TIGR00634 recN: DNA repair protein RecN 3 575 7.5E-160 T 09-03-2017 IPR004604 DNA recombination/repair protein RecN GO:0005524|GO:0006281|GO:0006310 TK78_RS28600 3b56b6b478e36f1917edc88125c58d29 581 Gene3D G3DSA:3.40.50.300 4 211 5.9E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28600 3b56b6b478e36f1917edc88125c58d29 581 PIRSF PIRSF003128 3 580 1.1E-152 T 09-03-2017 IPR004604 DNA recombination/repair protein RecN GO:0005524|GO:0006281|GO:0006310 TK78_RS05730 bc2e96869b3cfbdf3aeb712a64863ed9 515 Gene3D G3DSA:3.40.50.2300 152 337 2.1E-21 T 09-03-2017 TK78_RS05730 bc2e96869b3cfbdf3aeb712a64863ed9 515 Gene3D G3DSA:3.40.50.2300 338 445 1.1E-11 T 09-03-2017 TK78_RS05730 bc2e96869b3cfbdf3aeb712a64863ed9 515 Pfam PF13458 Periplasmic binding protein 152 494 2.4E-32 T 09-03-2017 IPR028081 Leucine-binding protein domain TK78_RS05730 bc2e96869b3cfbdf3aeb712a64863ed9 515 SUPERFAMILY SSF53822 152 500 1.21E-40 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS19120 96d936f651f65e4c42bd6af9485b242d 318 Pfam PF08032 RNA 2'-O ribose methyltransferase substrate binding 77 153 4.0E-18 T 09-03-2017 IPR013123 RNA 2-O ribose methyltransferase, substrate binding GO:0008168 TK78_RS19120 96d936f651f65e4c42bd6af9485b242d 318 Gene3D G3DSA:3.30.1330.30 73 149 1.8E-17 T 09-03-2017 IPR029064 50S ribosomal protein L30e-like TK78_RS19120 96d936f651f65e4c42bd6af9485b242d 318 Gene3D G3DSA:3.40.1280.10 163 317 1.3E-46 T 09-03-2017 IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal TK78_RS19120 96d936f651f65e4c42bd6af9485b242d 318 TIGRFAM TIGR00186 rRNA_methyl_3: RNA methyltransferase, TrmH family, group 3 74 317 1.5E-58 T 09-03-2017 IPR004441 RNA methyltransferase TrmH family GO:0006396|GO:0008173 TK78_RS19120 96d936f651f65e4c42bd6af9485b242d 318 SUPERFAMILY SSF55315 72 150 1.65E-14 T 09-03-2017 IPR029064 50S ribosomal protein L30e-like TK78_RS19120 96d936f651f65e4c42bd6af9485b242d 318 SUPERFAMILY SSF75217 141 317 3.34E-41 T 09-03-2017 IPR029028 Alpha/beta knot methyltransferases TK78_RS19120 96d936f651f65e4c42bd6af9485b242d 318 Pfam PF00588 SpoU rRNA Methylase family 170 311 7.3E-32 T 09-03-2017 IPR001537 tRNA/rRNA methyltransferase, SpoU type GO:0003723|GO:0006396|GO:0008173 TK78_RS19120 96d936f651f65e4c42bd6af9485b242d 318 SMART SM00967 76 153 1.5E-18 T 09-03-2017 IPR013123 RNA 2-O ribose methyltransferase, substrate binding GO:0008168 TK78_RS09780 125aa76877e054da0c02dd1ddfe1f264 395 SUPERFAMILY SSF55190 9 97 3.66E-11 T 09-03-2017 IPR005148 Arginyl tRNA synthetase N-terminal domain GO:0000166|GO:0004814|GO:0005524|GO:0005737|GO:0006420 KEGG: 00970+6.1.1.19 TK78_RS09780 125aa76877e054da0c02dd1ddfe1f264 395 Pfam PF05746 DALR anticodon binding domain 299 395 1.6E-14 T 09-03-2017 IPR008909 DALR anticodon binding GO:0004814|GO:0005524|GO:0006420 TK78_RS09780 125aa76877e054da0c02dd1ddfe1f264 395 SMART SM00836 236 395 3.3E-16 T 09-03-2017 IPR008909 DALR anticodon binding GO:0004814|GO:0005524|GO:0006420 TK78_RS09780 125aa76877e054da0c02dd1ddfe1f264 395 SUPERFAMILY SSF47323 232 255 5.23E-16 T 09-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS09780 125aa76877e054da0c02dd1ddfe1f264 395 SUPERFAMILY SSF47323 299 395 5.23E-16 T 09-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS09780 125aa76877e054da0c02dd1ddfe1f264 395 Gene3D G3DSA:1.10.730.10 232 260 5.0E-23 T 09-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS09780 125aa76877e054da0c02dd1ddfe1f264 395 Gene3D G3DSA:1.10.730.10 298 395 5.0E-23 T 09-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS09780 125aa76877e054da0c02dd1ddfe1f264 395 Gene3D G3DSA:3.30.1360.70 3 99 2.0E-18 T 09-03-2017 IPR005148 Arginyl tRNA synthetase N-terminal domain GO:0000166|GO:0004814|GO:0005524|GO:0005737|GO:0006420 KEGG: 00970+6.1.1.19 TK78_RS09780 125aa76877e054da0c02dd1ddfe1f264 395 Pfam PF03485 Arginyl tRNA synthetase N terminal domain 12 92 1.4E-10 T 09-03-2017 IPR005148 Arginyl tRNA synthetase N-terminal domain GO:0000166|GO:0004814|GO:0005524|GO:0005737|GO:0006420 KEGG: 00970+6.1.1.19 TK78_RS09780 125aa76877e054da0c02dd1ddfe1f264 395 SMART SM01016 4 92 3.7E-17 T 09-03-2017 IPR005148 Arginyl tRNA synthetase N-terminal domain GO:0000166|GO:0004814|GO:0005524|GO:0005737|GO:0006420 KEGG: 00970+6.1.1.19 TK78_RS34405 6b017d80655178dbdc9c5d1c15430c13 282 Pfam PF13460 NAD(P)H-binding 6 178 1.1E-21 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS34405 6b017d80655178dbdc9c5d1c15430c13 282 Gene3D G3DSA:3.40.50.720 2 212 7.2E-38 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS34405 6b017d80655178dbdc9c5d1c15430c13 282 SUPERFAMILY SSF51735 2 275 5.81E-51 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS05625 a868414f1ef399642c3c223e564fda30 709 Gene3D G3DSA:2.60.40.1180 594 707 5.4E-34 T 09-03-2017 IPR013780 Glycosyl hydrolase, all-beta TK78_RS05625 a868414f1ef399642c3c223e564fda30 709 Gene3D G3DSA:2.60.40.10 5 151 6.5E-53 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS05625 a868414f1ef399642c3c223e564fda30 709 SMART SM00642 176 572 1.2E-7 T 09-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 TK78_RS05625 a868414f1ef399642c3c223e564fda30 709 TIGRFAM TIGR02100 glgX_debranch: glycogen debranching enzyme GlgX 6 706 2.7E-298 T 09-03-2017 IPR011837 Glycogen debranching enzyme, GlgX type GO:0004133|GO:0004553|GO:0005980 TK78_RS05625 a868414f1ef399642c3c223e564fda30 709 Pfam PF02922 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) 10 96 5.6E-16 T 09-03-2017 IPR004193 Glycoside hydrolase, family 13, N-terminal GO:0004553|GO:0005975 Reactome: R-HSA-3322077|Reactome: R-HSA-3878781 TK78_RS05625 a868414f1ef399642c3c223e564fda30 709 SUPERFAMILY SSF51011 595 706 1.37E-24 T 09-03-2017 TK78_RS05625 a868414f1ef399642c3c223e564fda30 709 SUPERFAMILY SSF51445 133 470 1.49E-128 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS05625 a868414f1ef399642c3c223e564fda30 709 SUPERFAMILY SSF51445 499 580 1.49E-128 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS05625 a868414f1ef399642c3c223e564fda30 709 Gene3D G3DSA:3.20.20.80 152 580 2.3E-117 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS05625 a868414f1ef399642c3c223e564fda30 709 SUPERFAMILY SSF81296 5 147 2.13E-42 T 09-03-2017 IPR014756 Immunoglobulin E-set TK78_RS05625 a868414f1ef399642c3c223e564fda30 709 Pfam PF00128 Alpha amylase, catalytic domain 189 277 1.3E-7 T 09-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 TK78_RS28875 c92daf6b5e5ae66b118e5b5e462174a2 1311 Pfam PF00931 NB-ARC domain 522 684 4.8E-8 T 09-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 TK78_RS28875 c92daf6b5e5ae66b118e5b5e462174a2 1311 Pfam PF13676 TIR domain 342 445 8.1E-15 T 09-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 TK78_RS28875 c92daf6b5e5ae66b118e5b5e462174a2 1311 Gene3D G3DSA:3.40.50.300 6 247 1.2E-27 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28875 c92daf6b5e5ae66b118e5b5e462174a2 1311 SUPERFAMILY SSF48452 1121 1272 2.48E-13 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS28875 c92daf6b5e5ae66b118e5b5e462174a2 1311 SUPERFAMILY SSF48452 995 1105 2.37E-9 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS28875 c92daf6b5e5ae66b118e5b5e462174a2 1311 Gene3D G3DSA:1.25.40.10 1130 1288 3.7E-8 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS28875 c92daf6b5e5ae66b118e5b5e462174a2 1311 SUPERFAMILY SSF52540 481 732 2.07E-27 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28875 c92daf6b5e5ae66b118e5b5e462174a2 1311 Gene3D G3DSA:3.40.50.10140 339 435 4.0E-4 T 09-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 TK78_RS28875 c92daf6b5e5ae66b118e5b5e462174a2 1311 Pfam PF13424 Tetratricopeptide repeat 921 986 1.1E-9 T 09-03-2017 TK78_RS28875 c92daf6b5e5ae66b118e5b5e462174a2 1311 Pfam PF13424 Tetratricopeptide repeat 999 1069 1.2E-10 T 09-03-2017 TK78_RS28875 c92daf6b5e5ae66b118e5b5e462174a2 1311 Pfam PF13424 Tetratricopeptide repeat 1130 1198 1.1E-9 T 09-03-2017 TK78_RS28875 c92daf6b5e5ae66b118e5b5e462174a2 1311 Pfam PF01656 CobQ/CobB/MinD/ParA nucleotide binding domain 11 214 9.1E-10 T 09-03-2017 IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain TK78_RS28875 c92daf6b5e5ae66b118e5b5e462174a2 1311 SUPERFAMILY SSF52200 339 434 4.19E-7 T 09-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 TK78_RS28875 c92daf6b5e5ae66b118e5b5e462174a2 1311 Gene3D G3DSA:1.25.40.10 918 1105 1.8E-9 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS28875 c92daf6b5e5ae66b118e5b5e462174a2 1311 SUPERFAMILY SSF48452 870 1021 1.24E-12 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS28875 c92daf6b5e5ae66b118e5b5e462174a2 1311 SUPERFAMILY SSF52540 1 244 2.85E-20 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23315 e4752638681ea9c20c3f8f8c3ddce226 535 PIRSF PIRSF500125 14 529 2.3E-268 T 09-03-2017 IPR024677 4-HPA 3-monooxygenase large component/Pyoverdin chromophore biosynthetic protein TK78_RS23315 e4752638681ea9c20c3f8f8c3ddce226 535 Gene3D G3DSA:1.10.3140.10 26 165 2.8E-57 T 09-03-2017 TK78_RS23315 e4752638681ea9c20c3f8f8c3ddce226 535 Gene3D G3DSA:2.40.110.10 166 285 8.7E-48 T 09-03-2017 TK78_RS23315 e4752638681ea9c20c3f8f8c3ddce226 535 Gene3D G3DSA:1.20.140.10 286 497 3.4E-36 T 09-03-2017 TK78_RS23315 e4752638681ea9c20c3f8f8c3ddce226 535 SUPERFAMILY SSF47203 284 505 4.6E-52 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS23315 e4752638681ea9c20c3f8f8c3ddce226 535 Pfam PF03241 4-hydroxyphenylacetate 3-hydroxylase C terminal 301 501 4.8E-69 T 09-03-2017 IPR024719 HpaB/PvcC/4-BUDH C-terminal TK78_RS23315 e4752638681ea9c20c3f8f8c3ddce226 535 Pfam PF11794 4-hydroxyphenylacetate 3-hydroxylase N terminal 29 293 2.4E-96 T 09-03-2017 IPR024674 HpaB/PvcC/4-BUDH N-terminal TK78_RS23315 e4752638681ea9c20c3f8f8c3ddce226 535 SUPERFAMILY SSF56645 27 294 1.83E-83 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS23315 e4752638681ea9c20c3f8f8c3ddce226 535 PIRSF PIRSF000331 25 513 8.0E-211 T 09-03-2017 IPR004925 HpaB/PvcC/4-BUDH TK78_RS15760 bdd18d97dbe960ad30b63ce25e44400c 182 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 35 58 1.6E-5 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS15760 bdd18d97dbe960ad30b63ce25e44400c 182 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 14 27 1.6E-5 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS15760 bdd18d97dbe960ad30b63ce25e44400c 182 Gene3D G3DSA:1.10.357.10 9 177 1.7E-32 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS15760 bdd18d97dbe960ad30b63ce25e44400c 182 SUPERFAMILY SSF46689 4 82 1.49E-16 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS15760 bdd18d97dbe960ad30b63ce25e44400c 182 SUPERFAMILY SSF48498 98 175 2.05E-6 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS15760 bdd18d97dbe960ad30b63ce25e44400c 182 Pfam PF00440 Bacterial regulatory proteins, tetR family 14 60 1.3E-10 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS12715 d23c2653641700a5feb9b53e323c2ebb 191 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 23 186 3.8E-23 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12715 d23c2653641700a5feb9b53e323c2ebb 191 PRINTS PR00046 Major sigma-70 factor signature 56 69 5.3E-5 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12715 d23c2653641700a5feb9b53e323c2ebb 191 PRINTS PR00046 Major sigma-70 factor signature 142 154 5.3E-5 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12715 d23c2653641700a5feb9b53e323c2ebb 191 PRINTS PR00046 Major sigma-70 factor signature 159 174 5.3E-5 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12715 d23c2653641700a5feb9b53e323c2ebb 191 PRINTS PR00046 Major sigma-70 factor signature 174 185 5.3E-5 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12715 d23c2653641700a5feb9b53e323c2ebb 191 SUPERFAMILY SSF88946 11 112 6.87E-15 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12715 d23c2653641700a5feb9b53e323c2ebb 191 Gene3D G3DSA:1.10.1740.10 11 125 2.0E-15 T 09-03-2017 TK78_RS12715 d23c2653641700a5feb9b53e323c2ebb 191 SUPERFAMILY SSF88659 116 189 2.62E-14 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12715 d23c2653641700a5feb9b53e323c2ebb 191 Pfam PF04545 Sigma-70, region 4 138 187 5.2E-12 T 09-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12715 d23c2653641700a5feb9b53e323c2ebb 191 Gene3D G3DSA:1.10.10.10 134 189 9.1E-14 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS12715 d23c2653641700a5feb9b53e323c2ebb 191 Pfam PF04542 Sigma-70 region 2 27 98 6.9E-10 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS08735 d0a5032b31bd08e6c311677a0bb956e7 540 Gene3D G3DSA:3.20.20.140 482 519 1.3E-4 T 09-03-2017 TK78_RS08735 d0a5032b31bd08e6c311677a0bb956e7 540 SUPERFAMILY SSF51556 195 494 6.29E-38 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS08735 d0a5032b31bd08e6c311677a0bb956e7 540 SUPERFAMILY SSF51556 62 119 6.29E-38 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS08735 d0a5032b31bd08e6c311677a0bb956e7 540 SUPERFAMILY SSF51338 494 537 7.92E-17 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS08735 d0a5032b31bd08e6c311677a0bb956e7 540 SUPERFAMILY SSF51338 4 63 7.92E-17 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS08735 d0a5032b31bd08e6c311677a0bb956e7 540 Pfam PF07969 Amidohydrolase family 52 534 1.1E-81 T 09-03-2017 IPR013108 Amidohydrolase 3 TK78_RS08735 d0a5032b31bd08e6c311677a0bb956e7 540 Gene3D G3DSA:2.30.40.10 3 91 9.6E-14 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS08735 d0a5032b31bd08e6c311677a0bb956e7 540 Gene3D G3DSA:3.20.20.140 201 481 5.4E-45 T 09-03-2017 TK78_RS08190 4b9202b83f63cf0e4fb2c856bb16dfbc 819 Hamap MF_00277 Bifunctional uridylyltransferase/uridylyl-removing enzyme [glnD]. 1 819 92.442 T 09-03-2017 IPR010043 Bifunctional uridylyltransferase/uridylyl-removing enzyme GO:0006807|GO:0008773 TK78_RS08190 4b9202b83f63cf0e4fb2c856bb16dfbc 819 SMART SM00471 435 567 9.9E-9 T 09-03-2017 IPR003607 HD/PDEase domain TK78_RS08190 4b9202b83f63cf0e4fb2c856bb16dfbc 819 Pfam PF08335 GlnD PII-uridylyltransferase 213 287 9.7E-8 T 09-03-2017 IPR013546 PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase GO:0016779 TK78_RS08190 4b9202b83f63cf0e4fb2c856bb16dfbc 819 SUPERFAMILY SSF81593 192 285 5.96E-7 T 09-03-2017 TK78_RS08190 4b9202b83f63cf0e4fb2c856bb16dfbc 819 SUPERFAMILY SSF81301 38 161 4.36E-15 T 09-03-2017 TK78_RS08190 4b9202b83f63cf0e4fb2c856bb16dfbc 819 Gene3D G3DSA:1.10.3210.10 434 581 3.1E-20 T 09-03-2017 IPR006674 HD domain TK78_RS08190 4b9202b83f63cf0e4fb2c856bb16dfbc 819 Gene3D G3DSA:3.30.70.260 748 806 3.0E-7 T 09-03-2017 TK78_RS08190 4b9202b83f63cf0e4fb2c856bb16dfbc 819 SUPERFAMILY SSF55021 747 803 6.25E-7 T 09-03-2017 TK78_RS08190 4b9202b83f63cf0e4fb2c856bb16dfbc 819 Pfam PF01966 HD domain 440 556 9.5E-12 T 09-03-2017 IPR006674 HD domain TK78_RS08190 4b9202b83f63cf0e4fb2c856bb16dfbc 819 SUPERFAMILY SSF109604 409 554 1.57E-15 T 09-03-2017 TK78_RS08190 4b9202b83f63cf0e4fb2c856bb16dfbc 819 TIGRFAM TIGR01693 UTase_glnD: protein-P-II uridylyltransferase 24 610 8.9E-198 T 09-03-2017 IPR010043 Bifunctional uridylyltransferase/uridylyl-removing enzyme GO:0006807|GO:0008773 TK78_RS08190 4b9202b83f63cf0e4fb2c856bb16dfbc 819 Gene3D G3DSA:3.30.460.10 64 125 1.9E-4 T 09-03-2017 TK78_RS00890 78e5d4df6e53e65cabdb7764ff01ddf0 534 SUPERFAMILY SSF88946 4 99 1.88E-22 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS00890 78e5d4df6e53e65cabdb7764ff01ddf0 534 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 20 183 1.6E-18 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS00890 78e5d4df6e53e65cabdb7764ff01ddf0 534 Gene3D G3DSA:3.40.33.10 412 528 3.9E-13 T 09-03-2017 IPR014044 CAP domain TK78_RS00890 78e5d4df6e53e65cabdb7764ff01ddf0 534 Gene3D G3DSA:1.10.1740.10 7 108 1.8E-23 T 09-03-2017 TK78_RS00890 78e5d4df6e53e65cabdb7764ff01ddf0 534 Pfam PF00188 Cysteine-rich secretory protein family 417 531 1.3E-21 T 09-03-2017 IPR014044 CAP domain TK78_RS00890 78e5d4df6e53e65cabdb7764ff01ddf0 534 Pfam PF04542 Sigma-70 region 2 24 90 1.8E-15 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS00890 78e5d4df6e53e65cabdb7764ff01ddf0 534 SUPERFAMILY SSF55797 409 532 7.85E-24 T 09-03-2017 IPR014044 CAP domain TK78_RS33175 18f78e121010bad7e651d98fcb204975 286 Pfam PF12697 Alpha/beta hydrolase family 55 278 1.4E-11 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS33175 18f78e121010bad7e651d98fcb204975 286 SUPERFAMILY SSF53474 42 282 9.28E-36 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS33175 18f78e121010bad7e651d98fcb204975 286 Gene3D G3DSA:3.40.50.1820 31 282 7.1E-40 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS01380 c425cc1dc15e993cb7cd71fcb7640d2f 278 SUPERFAMILY SSF53955 181 275 1.19E-14 T 09-03-2017 IPR023346 Lysozyme-like domain TK78_RS01380 c425cc1dc15e993cb7cd71fcb7640d2f 278 Pfam PF01464 Transglycosylase SLT domain 203 274 4.3E-9 T 09-03-2017 IPR008258 Transglycosylase SLT domain 1 TK78_RS01380 c425cc1dc15e993cb7cd71fcb7640d2f 278 SMART SM00257 71 120 1.2E-4 T 09-03-2017 IPR018392 LysM domain TK78_RS01380 c425cc1dc15e993cb7cd71fcb7640d2f 278 Gene3D G3DSA:1.10.530.10 199 277 4.2E-10 T 09-03-2017 TK78_RS01380 c425cc1dc15e993cb7cd71fcb7640d2f 278 Pfam PF01476 LysM domain 72 119 1.8E-6 T 09-03-2017 IPR018392 LysM domain TK78_RS01380 c425cc1dc15e993cb7cd71fcb7640d2f 278 Gene3D G3DSA:3.10.350.10 72 119 1.9E-7 T 09-03-2017 IPR018392 LysM domain TK78_RS34045 33433b1d5767a05191002a0bf5d921b7 225 Gene3D G3DSA:2.30.110.10 85 217 4.1E-37 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS34045 33433b1d5767a05191002a0bf5d921b7 225 Gene3D G3DSA:1.10.260.40 12 73 2.3E-11 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS34045 33433b1d5767a05191002a0bf5d921b7 225 Pfam PF12900 Pyridoxamine 5'-phosphate oxidase 94 214 4.2E-22 T 09-03-2017 IPR024747 Pyridoxamine 5'-phosphate oxidase-related TK78_RS34045 33433b1d5767a05191002a0bf5d921b7 225 SMART SM00530 15 70 1.2E-8 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS34045 33433b1d5767a05191002a0bf5d921b7 225 Pfam PF13560 Helix-turn-helix domain 11 69 1.4E-7 T 09-03-2017 TK78_RS34045 33433b1d5767a05191002a0bf5d921b7 225 SUPERFAMILY SSF47413 12 74 3.66E-10 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS34045 33433b1d5767a05191002a0bf5d921b7 225 SUPERFAMILY SSF50475 90 214 6.38E-21 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS16165 774c03c7130a332910a6b402b34b737c 1445 Pfam PF05593 RHS Repeat 714 750 2.3E-7 T 09-03-2017 IPR031325 RHS repeat TK78_RS16165 774c03c7130a332910a6b402b34b737c 1445 Pfam PF05593 RHS Repeat 1048 1082 2.9E-7 T 09-03-2017 IPR031325 RHS repeat TK78_RS16165 774c03c7130a332910a6b402b34b737c 1445 Pfam PF05593 RHS Repeat 1242 1271 9.1E-6 T 09-03-2017 IPR031325 RHS repeat TK78_RS16165 774c03c7130a332910a6b402b34b737c 1445 Pfam PF05593 RHS Repeat 1027 1062 6.5E-6 T 09-03-2017 IPR031325 RHS repeat TK78_RS16165 774c03c7130a332910a6b402b34b737c 1445 Pfam PF05593 RHS Repeat 605 632 1.4E-4 T 09-03-2017 IPR031325 RHS repeat TK78_RS16165 774c03c7130a332910a6b402b34b737c 1445 Pfam PF05593 RHS Repeat 967 1000 7.6E-5 T 09-03-2017 IPR031325 RHS repeat TK78_RS16165 774c03c7130a332910a6b402b34b737c 1445 Pfam PF05593 RHS Repeat 821 855 1.7E-6 T 09-03-2017 IPR031325 RHS repeat TK78_RS16165 774c03c7130a332910a6b402b34b737c 1445 Pfam PF05593 RHS Repeat 925 961 3.2E-8 T 09-03-2017 IPR031325 RHS repeat TK78_RS16165 774c03c7130a332910a6b402b34b737c 1445 Pfam PF05593 RHS Repeat 777 813 5.8E-11 T 09-03-2017 IPR031325 RHS repeat TK78_RS16165 774c03c7130a332910a6b402b34b737c 1445 Pfam PF05593 RHS Repeat 988 1022 9.5E-7 T 09-03-2017 IPR031325 RHS repeat TK78_RS16165 774c03c7130a332910a6b402b34b737c 1445 SUPERFAMILY SSF63829 838 1079 2.16E-5 T 09-03-2017 TK78_RS16165 774c03c7130a332910a6b402b34b737c 1445 TIGRFAM TIGR03696 Rhs_assc_core: RHS repeat-associated core domain 1370 1444 4.0E-22 T 09-03-2017 IPR022385 Rhs repeat-associated core GO:0097264 TK78_RS16165 774c03c7130a332910a6b402b34b737c 1445 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 924 965 1.0E-8 T 09-03-2017 IPR006530 YD repeat TK78_RS16165 774c03c7130a332910a6b402b34b737c 1445 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 778 817 1.1E-9 T 09-03-2017 IPR006530 YD repeat TK78_RS16165 774c03c7130a332910a6b402b34b737c 1445 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 1242 1272 3.0E-7 T 09-03-2017 IPR006530 YD repeat TK78_RS16165 774c03c7130a332910a6b402b34b737c 1445 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 694 733 2.6E-6 T 09-03-2017 IPR006530 YD repeat TK78_RS16165 774c03c7130a332910a6b402b34b737c 1445 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 1047 1082 2.0E-5 T 09-03-2017 IPR006530 YD repeat TK78_RS16165 774c03c7130a332910a6b402b34b737c 1445 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 822 858 5.0E-6 T 09-03-2017 IPR006530 YD repeat TK78_RS16165 774c03c7130a332910a6b402b34b737c 1445 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 606 643 4.5E-7 T 09-03-2017 IPR006530 YD repeat TK78_RS16165 774c03c7130a332910a6b402b34b737c 1445 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 1027 1066 0.001 T 09-03-2017 IPR006530 YD repeat TK78_RS16165 774c03c7130a332910a6b402b34b737c 1445 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 863 902 8.4E-6 T 09-03-2017 IPR006530 YD repeat TK78_RS04140 436d9c226aa1f307911bebc0bdee43d6 277 Pfam PF04951 D-aminopeptidase 1 262 3.1E-90 T 09-03-2017 IPR007035 Peptidase M55, D-aminopeptidase TK78_RS04140 436d9c226aa1f307911bebc0bdee43d6 277 SUPERFAMILY SSF63992 1 267 2.35E-82 T 09-03-2017 IPR007035 Peptidase M55, D-aminopeptidase TK78_RS04140 436d9c226aa1f307911bebc0bdee43d6 277 Gene3D G3DSA:3.30.1360.130 217 267 1.5E-6 T 09-03-2017 TK78_RS04140 436d9c226aa1f307911bebc0bdee43d6 277 Gene3D G3DSA:3.40.50.10780 1 213 6.7E-75 T 09-03-2017 IPR027476 D-aminopeptidase, N-terminal TK78_RS04140 436d9c226aa1f307911bebc0bdee43d6 277 PIRSF PIRSF015853 1 274 1.1E-94 T 09-03-2017 IPR007035 Peptidase M55, D-aminopeptidase TK78_RS12010 0cb4c7e475030eab833edc1e5d7f9563 822 Gene3D G3DSA:3.40.50.300 98 136 9.2E-4 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS12010 0cb4c7e475030eab833edc1e5d7f9563 822 Gene3D G3DSA:1.25.40.10 539 784 1.3E-13 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS12010 0cb4c7e475030eab833edc1e5d7f9563 822 Pfam PF13374 Tetratricopeptide repeat 540 579 0.0072 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS12010 0cb4c7e475030eab833edc1e5d7f9563 822 Pfam PF13374 Tetratricopeptide repeat 636 663 0.018 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS12010 0cb4c7e475030eab833edc1e5d7f9563 822 Pfam PF13374 Tetratricopeptide repeat 756 787 0.019 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS12010 0cb4c7e475030eab833edc1e5d7f9563 822 Pfam PF13424 Tetratricopeptide repeat 679 738 4.0E-11 T 09-03-2017 TK78_RS12010 0cb4c7e475030eab833edc1e5d7f9563 822 SUPERFAMILY SSF48452 499 600 6.32E-5 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS12010 0cb4c7e475030eab833edc1e5d7f9563 822 SUPERFAMILY SSF52540 79 292 1.21E-17 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS12010 0cb4c7e475030eab833edc1e5d7f9563 822 SUPERFAMILY SSF48452 577 695 4.17E-9 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS12010 0cb4c7e475030eab833edc1e5d7f9563 822 SUPERFAMILY SSF48452 659 782 3.8E-14 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS13130 e7a0d19c666ddf8fd3a6943d1fc38c3b 139 Gene3D G3DSA:3.90.1170.10 23 136 7.5E-52 T 09-03-2017 IPR016180 Ribosomal protein L10e/L16 GO:0003735|GO:0005840|GO:0006412 TK78_RS13130 e7a0d19c666ddf8fd3a6943d1fc38c3b 139 ProSitePatterns PS00701 Ribosomal protein L16 signature 2. 82 93 - T 09-03-2017 IPR020798 Ribosomal protein L16, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13130 e7a0d19c666ddf8fd3a6943d1fc38c3b 139 Hamap MF_01342 50S ribosomal protein L16 [rplP]. 1 134 37.763 T 09-03-2017 IPR000114 Ribosomal protein L16 GO:0003735|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13130 e7a0d19c666ddf8fd3a6943d1fc38c3b 139 PRINTS PR00060 Ribosomal protein L16 signature 58 87 5.2E-38 T 09-03-2017 IPR000114 Ribosomal protein L16 GO:0003735|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13130 e7a0d19c666ddf8fd3a6943d1fc38c3b 139 PRINTS PR00060 Ribosomal protein L16 signature 42 53 5.2E-38 T 09-03-2017 IPR000114 Ribosomal protein L16 GO:0003735|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13130 e7a0d19c666ddf8fd3a6943d1fc38c3b 139 PRINTS PR00060 Ribosomal protein L16 signature 88 117 5.2E-38 T 09-03-2017 IPR000114 Ribosomal protein L16 GO:0003735|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13130 e7a0d19c666ddf8fd3a6943d1fc38c3b 139 PRINTS PR00060 Ribosomal protein L16 signature 24 36 5.2E-38 T 09-03-2017 IPR000114 Ribosomal protein L16 GO:0003735|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13130 e7a0d19c666ddf8fd3a6943d1fc38c3b 139 Pfam PF00252 Ribosomal protein L16p/L10e 4 132 5.2E-47 T 09-03-2017 IPR016180 Ribosomal protein L10e/L16 GO:0003735|GO:0005840|GO:0006412 TK78_RS13130 e7a0d19c666ddf8fd3a6943d1fc38c3b 139 SUPERFAMILY SSF54686 1 135 1.31E-54 T 09-03-2017 IPR016180 Ribosomal protein L10e/L16 GO:0003735|GO:0005840|GO:0006412 TK78_RS13130 e7a0d19c666ddf8fd3a6943d1fc38c3b 139 ProSitePatterns PS00586 Ribosomal protein L16 signature 1. 59 70 - T 09-03-2017 IPR020798 Ribosomal protein L16, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13130 e7a0d19c666ddf8fd3a6943d1fc38c3b 139 TIGRFAM TIGR01164 rplP_bact: ribosomal protein uL16 2 127 4.8E-54 T 09-03-2017 IPR000114 Ribosomal protein L16 GO:0003735|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS14005 037b1b386ae924191291173f14435e1a 173 SUPERFAMILY SSF47473 3 171 1.66E-23 T 09-03-2017 IPR011992 EF-hand domain pair TK78_RS14005 037b1b386ae924191291173f14435e1a 173 ProSitePatterns PS00018 EF-hand calcium-binding domain. 69 81 - T 09-03-2017 IPR018247 EF-Hand 1, calcium-binding site TK78_RS14005 037b1b386ae924191291173f14435e1a 173 Gene3D G3DSA:1.10.238.10 6 162 6.7E-24 T 09-03-2017 IPR011992 EF-hand domain pair TK78_RS14005 037b1b386ae924191291173f14435e1a 173 ProSitePatterns PS00018 EF-hand calcium-binding domain. 146 158 - T 09-03-2017 IPR018247 EF-Hand 1, calcium-binding site TK78_RS14005 037b1b386ae924191291173f14435e1a 173 Pfam PF13499 EF-hand domain pair 8 82 2.8E-8 T 09-03-2017 IPR002048 EF-hand domain GO:0005509 TK78_RS14005 037b1b386ae924191291173f14435e1a 173 SMART SM00054 9 37 0.073 T 09-03-2017 IPR002048 EF-hand domain GO:0005509 TK78_RS14005 037b1b386ae924191291173f14435e1a 173 SMART SM00054 60 88 14.0 T 09-03-2017 IPR002048 EF-hand domain GO:0005509 TK78_RS14005 037b1b386ae924191291173f14435e1a 173 ProSitePatterns PS00018 EF-hand calcium-binding domain. 18 30 - T 09-03-2017 IPR018247 EF-Hand 1, calcium-binding site TK78_RS06070 cb17440e1d35bf3a43af81db7d942335 308 Pfam PF01636 Phosphotransferase enzyme family 37 263 1.9E-37 T 09-03-2017 IPR002575 Aminoglycoside phosphotransferase TK78_RS06070 cb17440e1d35bf3a43af81db7d942335 308 Gene3D G3DSA:3.90.1200.10 109 272 4.8E-33 T 09-03-2017 TK78_RS06070 cb17440e1d35bf3a43af81db7d942335 308 SUPERFAMILY SSF56112 14 288 4.67E-44 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 SMART SM01096 426 547 9.1E-64 T 09-03-2017 IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 SMART SM00851 974 1065 1.1E-26 T 09-03-2017 IPR011607 Methylglyoxal synthase-like domain TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 SUPERFAMILY SSF52440 2 127 3.88E-47 T 09-03-2017 IPR016185 Pre-ATP-grasp domain TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 ProSitePatterns PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 713 727 - T 09-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 Gene3D G3DSA:1.10.1030.10 406 538 3.3E-46 T 09-03-2017 IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 SUPERFAMILY SSF48108 401 553 6.02E-47 T 09-03-2017 IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 Gene3D G3DSA:3.30.1490.20 690 748 1.1E-25 T 09-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 Gene3D G3DSA:3.30.1490.20 149 205 5.7E-19 T 09-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 TIGRFAM TIGR01369 CPSaseII_lrg: carbamoyl-phosphate synthase, large subunit 2 1074 0.0 T 09-03-2017 IPR006275 Carbamoyl-phosphate synthase, large subunit GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 SUPERFAMILY SSF52440 558 678 2.59E-42 T 09-03-2017 IPR016185 Pre-ATP-grasp domain TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 245 262 2.2E-63 T 09-03-2017 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 303 332 2.2E-63 T 09-03-2017 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 48 58 2.2E-63 T 09-03-2017 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 385 403 2.2E-63 T 09-03-2017 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 174 186 2.2E-63 T 09-03-2017 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 210 229 2.2E-63 T 09-03-2017 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 19 33 2.2E-63 T 09-03-2017 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 Gene3D G3DSA:3.40.50.1380 957 1096 2.4E-40 T 09-03-2017 IPR011607 Methylglyoxal synthase-like domain TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 Hamap MF_01210_B Carbamoyl-phosphate synthase large chain [carB]. 1 1086 13.005 T 09-03-2017 IPR006275 Carbamoyl-phosphate synthase, large subunit GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 Pfam PF02142 MGS-like domain 975 1065 2.2E-20 T 09-03-2017 IPR011607 Methylglyoxal synthase-like domain TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 Gene3D G3DSA:3.40.50.20 4 108 2.2E-42 T 09-03-2017 IPR016185 Pre-ATP-grasp domain TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 Gene3D G3DSA:3.40.50.20 539 665 9.7E-56 T 09-03-2017 IPR016185 Pre-ATP-grasp domain TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 ProSitePatterns PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 303 310 - T 09-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 SUPERFAMILY SSF56059 677 951 4.95E-90 T 09-03-2017 TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 SUPERFAMILY SSF56059 129 406 3.54E-100 T 09-03-2017 TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 ProSitePatterns PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 170 184 - T 09-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 Gene3D G3DSA:3.30.470.20 749 952 2.3E-60 T 09-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 Gene3D G3DSA:3.30.470.20 206 405 9.7E-78 T 09-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 ProSitePatterns PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 842 849 - T 09-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 Pfam PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 677 879 8.5E-34 T 09-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 Pfam PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 128 340 1.4E-65 T 09-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 Pfam PF02787 Carbamoyl-phosphate synthetase large chain, oligomerisation domain 431 547 2.9E-38 T 09-03-2017 IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 TK78_RS30320 51b4471c761cbc75c225dc2e9a437e5f 1102 SUPERFAMILY SSF52335 960 1094 2.49E-34 T 09-03-2017 IPR011607 Methylglyoxal synthase-like domain TK78_RS23020 6c421592b7dcfbd5bc0731c1a6194c63 645 SUPERFAMILY SSF50965 223 545 8.11E-35 T 09-03-2017 IPR011043 Galactose oxidase/kelch, beta-propeller TK78_RS23020 6c421592b7dcfbd5bc0731c1a6194c63 645 Gene3D G3DSA:2.130.10.80 57 136 2.2E-68 T 09-03-2017 IPR015916 Galactose oxidase, beta-propeller TK78_RS23020 6c421592b7dcfbd5bc0731c1a6194c63 645 Gene3D G3DSA:2.130.10.80 258 549 2.2E-68 T 09-03-2017 IPR015916 Galactose oxidase, beta-propeller TK78_RS23020 6c421592b7dcfbd5bc0731c1a6194c63 645 Pfam PF09118 Domain of unknown function (DUF1929) 549 643 9.9E-23 T 09-03-2017 IPR015202 Domain of unknown function DUF1929 TK78_RS23020 6c421592b7dcfbd5bc0731c1a6194c63 645 Gene3D G3DSA:2.60.40.10 550 643 2.5E-27 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS23020 6c421592b7dcfbd5bc0731c1a6194c63 645 SUPERFAMILY SSF50965 29 137 6.67E-6 T 09-03-2017 IPR011043 Galactose oxidase/kelch, beta-propeller TK78_RS23020 6c421592b7dcfbd5bc0731c1a6194c63 645 SUPERFAMILY SSF81296 545 643 1.37E-22 T 09-03-2017 IPR014756 Immunoglobulin E-set TK78_RS20905 8f28bc0e1bcd14881c64402c5f8aa0ee 169 SUPERFAMILY SSF55040 14 156 2.62E-56 T 09-03-2017 IPR002820 Molybdopterin cofactor biosynthesis C (MoaC) domain GO:0006777 Reactome: R-HSA-947581 TK78_RS20905 8f28bc0e1bcd14881c64402c5f8aa0ee 169 TIGRFAM TIGR00581 moaC: molybdenum cofactor biosynthesis protein C 7 153 9.3E-62 T 09-03-2017 IPR023045 Molybdenum cofactor biosynthesis C GO:0006777 Reactome: R-HSA-947581 TK78_RS20905 8f28bc0e1bcd14881c64402c5f8aa0ee 169 Gene3D G3DSA:3.30.70.640 6 158 4.5E-64 T 09-03-2017 IPR002820 Molybdopterin cofactor biosynthesis C (MoaC) domain GO:0006777 Reactome: R-HSA-947581 TK78_RS20905 8f28bc0e1bcd14881c64402c5f8aa0ee 169 Pfam PF01967 MoaC family 18 151 1.2E-51 T 09-03-2017 IPR002820 Molybdopterin cofactor biosynthesis C (MoaC) domain GO:0006777 Reactome: R-HSA-947581 TK78_RS20905 8f28bc0e1bcd14881c64402c5f8aa0ee 169 Hamap MF_01224_B Cyclic pyranopterin monophosphate synthase accessory protein [moaC]. 5 159 35.846 T 09-03-2017 IPR023046 Molybdenum cofactor biosynthesis C, bacterial-type Reactome: R-HSA-947581 TK78_RS20065 7dbb113401a4d7a4fd883c5ae0d48083 80 Pfam PF04149 Domain of unknown function (DUF397) 26 76 1.3E-20 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS20065 7dbb113401a4d7a4fd883c5ae0d48083 80 Pfam PF04149 Domain of unknown function (DUF397) 6 24 5.0E-7 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS33270 ba6260060d7ca209f7ed7d511bd84539 275 Pfam PF13688 Metallo-peptidase family M12 102 239 1.2E-8 T 09-03-2017 TK78_RS33270 ba6260060d7ca209f7ed7d511bd84539 275 SUPERFAMILY SSF55486 120 230 2.78E-8 T 09-03-2017 TK78_RS33270 ba6260060d7ca209f7ed7d511bd84539 275 Gene3D G3DSA:3.40.390.10 172 233 4.0E-7 T 09-03-2017 IPR024079 Metallopeptidase, catalytic domain GO:0008237 TK78_RS29320 6b4f04bd130d9269158096f950880726 305 Gene3D G3DSA:3.40.50.150 77 282 3.0E-66 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS29320 6b4f04bd130d9269158096f950880726 305 Gene3D G3DSA:3.10.330.20 2 75 1.3E-32 T 09-03-2017 TK78_RS29320 6b4f04bd130d9269158096f950880726 305 SUPERFAMILY SSF53335 13 266 1.76E-71 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS29320 6b4f04bd130d9269158096f950880726 305 Pfam PF08704 tRNA methyltransferase complex GCD14 subunit 80 244 3.1E-21 T 09-03-2017 IPR014816 tRNA (1-methyladenosine) methyltransferase catalytic subunit Gcd14 GO:0016429|GO:0030488|GO:0031515 KEGG: 00340+2.1.1.22|MetaCyc: PWY-6829 TK78_RS29320 6b4f04bd130d9269158096f950880726 305 Pfam PF14801 tRNA methyltransferase complex GCD14 subunit N-term 11 61 1.9E-28 T 09-03-2017 TK78_RS29320 6b4f04bd130d9269158096f950880726 305 PIRSF PIRSF017269 7 276 2.6E-87 T 09-03-2017 IPR014816 tRNA (1-methyladenosine) methyltransferase catalytic subunit Gcd14 GO:0016429|GO:0030488|GO:0031515 KEGG: 00340+2.1.1.22|MetaCyc: PWY-6829 TK78_RS30175 0838806e3c7afaa855d811301b0e865c 420 Gene3D G3DSA:3.30.930.10 219 319 8.2E-81 T 09-03-2017 TK78_RS30175 0838806e3c7afaa855d811301b0e865c 420 Gene3D G3DSA:3.30.930.10 3 185 8.2E-81 T 09-03-2017 TK78_RS30175 0838806e3c7afaa855d811301b0e865c 420 Gene3D G3DSA:3.40.50.800 326 418 3.4E-27 T 09-03-2017 IPR004154 Anticodon-binding TK78_RS30175 0838806e3c7afaa855d811301b0e865c 420 TIGRFAM TIGR00442 hisS: histidine--tRNA ligase 5 407 2.1E-133 T 09-03-2017 IPR015807 Histidine-tRNA ligase GO:0004821|GO:0005524|GO:0006427 KEGG: 00970+6.1.1.21 TK78_RS30175 0838806e3c7afaa855d811301b0e865c 420 PIRSF PIRSF001549 1 419 2.6E-102 T 09-03-2017 IPR004516 Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit GO:0005737 TK78_RS30175 0838806e3c7afaa855d811301b0e865c 420 SUPERFAMILY SSF52954 325 419 2.78E-22 T 09-03-2017 IPR004154 Anticodon-binding TK78_RS30175 0838806e3c7afaa855d811301b0e865c 420 Pfam PF13393 Histidyl-tRNA synthetase 9 309 7.8E-42 T 09-03-2017 TK78_RS30175 0838806e3c7afaa855d811301b0e865c 420 SUPERFAMILY SSF55681 4 315 1.21E-81 T 09-03-2017 TK78_RS30175 0838806e3c7afaa855d811301b0e865c 420 Hamap MF_00127 Histidine--tRNA ligase [hisS]. 2 417 30.435 T 09-03-2017 IPR015807 Histidine-tRNA ligase GO:0004821|GO:0005524|GO:0006427 KEGG: 00970+6.1.1.21 TK78_RS30175 0838806e3c7afaa855d811301b0e865c 420 Pfam PF03129 Anticodon binding domain 329 417 1.8E-11 T 09-03-2017 IPR004154 Anticodon-binding TK78_RS33435 b2abcadcef228429e6fa018023f93cff 205 SUPERFAMILY SSF101473 2 195 3.01E-55 T 09-03-2017 IPR004007 DhaL domain GO:0004371|GO:0006071 Reactome: R-HSA-168928|Reactome: R-HSA-70350 TK78_RS33435 b2abcadcef228429e6fa018023f93cff 205 Pfam PF02734 DAK2 domain 31 194 1.6E-49 T 09-03-2017 IPR004007 DhaL domain GO:0004371|GO:0006071 Reactome: R-HSA-168928|Reactome: R-HSA-70350 TK78_RS33435 b2abcadcef228429e6fa018023f93cff 205 SMART SM01120 31 195 3.4E-70 T 09-03-2017 IPR004007 DhaL domain GO:0004371|GO:0006071 Reactome: R-HSA-168928|Reactome: R-HSA-70350 TK78_RS33435 b2abcadcef228429e6fa018023f93cff 205 TIGRFAM TIGR02365 dha_L_ycgS: dihydroxyacetone kinase, L subunit 8 194 9.0E-69 T 09-03-2017 IPR012737 Dihydroxyacetone kinase, subunit L GO:0016772 TK78_RS32865 8490d70bcd91ce79226db01c72dd0f84 296 Gene3D G3DSA:1.10.10.10 11 87 2.3E-12 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32865 8490d70bcd91ce79226db01c72dd0f84 296 ProSitePatterns PS00894 DeoR-type HTH domain signature. 12 46 - T 09-03-2017 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 TK78_RS32865 8490d70bcd91ce79226db01c72dd0f84 296 SUPERFAMILY SSF100950 84 145 3.52E-29 T 09-03-2017 TK78_RS32865 8490d70bcd91ce79226db01c72dd0f84 296 SUPERFAMILY SSF100950 177 252 3.52E-29 T 09-03-2017 TK78_RS32865 8490d70bcd91ce79226db01c72dd0f84 296 Pfam PF08220 DeoR-like helix-turn-helix domain 12 63 2.1E-17 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS32865 8490d70bcd91ce79226db01c72dd0f84 296 SUPERFAMILY SSF46785 10 65 3.33E-13 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32865 8490d70bcd91ce79226db01c72dd0f84 296 SMART SM01134 80 251 1.7E-61 T 09-03-2017 TK78_RS32865 8490d70bcd91ce79226db01c72dd0f84 296 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 44 62 6.8E-10 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS32865 8490d70bcd91ce79226db01c72dd0f84 296 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 30 44 6.8E-10 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS32865 8490d70bcd91ce79226db01c72dd0f84 296 Pfam PF00455 DeoR C terminal sensor domain 83 249 7.8E-50 T 09-03-2017 IPR014036 DeoR C-terminal sensor domain TK78_RS32865 8490d70bcd91ce79226db01c72dd0f84 296 Gene3D G3DSA:3.40.50.1360 88 232 9.3E-14 T 09-03-2017 TK78_RS32865 8490d70bcd91ce79226db01c72dd0f84 296 SMART SM00420 12 64 2.3E-18 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS01030 0e26a50e79ae482122cbb76507845918 195 SUPERFAMILY SSF55846 48 192 4.32E-37 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS01030 0e26a50e79ae482122cbb76507845918 195 Pfam PF01510 N-acetylmuramoyl-L-alanine amidase 58 179 6.1E-20 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS01030 0e26a50e79ae482122cbb76507845918 195 SMART SM00644 49 179 2.3E-35 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS01030 0e26a50e79ae482122cbb76507845918 195 Gene3D G3DSA:3.40.80.10 49 193 5.8E-40 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS33180 03b0648454cf16d9a9272ea16b49ed4d 91 Pfam PF13586 Transposase DDE domain 2 80 1.2E-18 T 09-03-2017 IPR025668 Transposase DDE domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 SUPERFAMILY SSF52777 6 207 6.11E-41 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Pfam PF00668 Condensation domain 1057 1358 1.3E-32 T 09-03-2017 IPR001242 Condensation domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Pfam PF00668 Condensation domain 4087 4380 2.2E-64 T 09-03-2017 IPR001242 Condensation domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Pfam PF00668 Condensation domain 2562 2864 5.6E-59 T 09-03-2017 IPR001242 Condensation domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Pfam PF00668 Condensation domain 9 306 4.4E-57 T 09-03-2017 IPR001242 Condensation domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Pfam PF00668 Condensation domain 1541 1835 7.8E-55 T 09-03-2017 IPR001242 Condensation domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Pfam PF00668 Condensation domain 3650 3919 1.3E-18 T 09-03-2017 IPR001242 Condensation domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Pfam PF13193 AMP-binding enzyme C-terminal domain 2381 2452 5.1E-10 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Pfam PF13193 AMP-binding enzyme C-terminal domain 4956 5030 1.8E-10 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Pfam PF13193 AMP-binding enzyme C-terminal domain 878 953 2.6E-14 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Pfam PF13193 AMP-binding enzyme C-terminal domain 3440 3515 9.1E-11 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 SUPERFAMILY SSF52777 1537 1736 9.78E-41 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 ProSitePatterns PS00455 Putative AMP-binding domain signature. 4688 4699 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Gene3D G3DSA:3.30.300.30 3428 3543 3.1E-32 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Gene3D G3DSA:3.30.300.30 865 981 8.2E-37 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Gene3D G3DSA:3.30.300.30 4943 5059 3.4E-33 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Gene3D G3DSA:3.30.300.30 2368 2481 3.1E-35 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Pfam PF00501 AMP-binding enzyme 3033 3432 2.8E-100 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Pfam PF00501 AMP-binding enzyme 1995 2373 1.7E-88 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Pfam PF00501 AMP-binding enzyme 476 870 1.9E-83 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Pfam PF00501 AMP-binding enzyme 4541 4948 7.3E-91 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 SUPERFAMILY SSF52777 4084 4281 1.45E-43 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 SUPERFAMILY SSF52777 3618 3788 1.78E-23 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 SUPERFAMILY SSF47336 3533 3602 6.67E-16 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 SUPERFAMILY SSF52777 1058 1255 1.7E-29 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 SUPERFAMILY SSF56801 3005 3553 4.71E-155 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 SUPERFAMILY SSF52777 2751 2999 5.0E-60 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 SUPERFAMILY SSF47336 5048 5119 2.09E-14 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 SUPERFAMILY SSF56801 1984 2490 3.14E-142 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 SUPERFAMILY SSF47336 971 1040 4.97E-17 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1002 1017 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Gene3D G3DSA:3.40.50.980 2144 2284 6.7E-34 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 SUPERFAMILY SSF52777 4266 4526 8.23E-53 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Gene3D G3DSA:2.30.38.10 4861 4938 4.9E-25 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Gene3D G3DSA:2.30.38.10 2285 2362 1.4E-24 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Gene3D G3DSA:2.30.38.10 3344 3421 2.6E-26 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Gene3D G3DSA:2.30.38.10 782 859 6.2E-22 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 SUPERFAMILY SSF56801 434 991 4.84E-144 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Pfam PF13745 HxxPF-repeated domain 2886 2977 2.9E-29 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Gene3D G3DSA:1.10.1200.10 2482 2542 9.3E-27 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Gene3D G3DSA:1.10.1200.10 5060 5124 1.1E-19 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Gene3D G3DSA:1.10.1200.10 982 1044 2.9E-25 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Gene3D G3DSA:1.10.1200.10 3544 3606 7.9E-22 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 SUPERFAMILY SSF56801 4502 5067 5.1E-144 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 SUPERFAMILY SSF52777 1722 1968 6.67E-48 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 ProSitePatterns PS00455 Putative AMP-binding domain signature. 3176 3187 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Gene3D G3DSA:3.40.50.980 3182 3343 3.6E-47 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Gene3D G3DSA:3.40.50.980 631 781 5.3E-31 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Gene3D G3DSA:3.40.50.980 4697 4860 1.2E-29 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Pfam PF00550 Phosphopantetheine attachment site 3542 3603 4.4E-13 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Pfam PF00550 Phosphopantetheine attachment site 2480 2541 4.8E-17 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Pfam PF00550 Phosphopantetheine attachment site 5057 5116 1.2E-10 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Pfam PF00550 Phosphopantetheine attachment site 980 1041 1.6E-12 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 SUPERFAMILY SSF52777 1241 1504 3.56E-27 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 SUPERFAMILY SSF52777 192 440 1.48E-47 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 SUPERFAMILY SSF47336 2470 2542 9.55E-21 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 ProSitePatterns PS00455 Putative AMP-binding domain signature. 620 631 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 4562 4972 1.7E-119 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 3052 3456 3.1E-135 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 497 894 4.1E-123 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 2015 2397 2.4E-112 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 SUPERFAMILY SSF52777 2565 2740 3.78E-42 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 TIGRFAM TIGR01720 NRPS-para261: non-ribosomal peptide synthase domain TIGR01720 1369 1532 5.1E-32 T 09-03-2017 IPR010060 Non-ribosomal peptide synthase TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Gene3D G3DSA:3.40.50.980 3027 3181 7.5E-44 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 SUPERFAMILY SSF52777 3806 4054 8.67E-21 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Gene3D G3DSA:3.40.50.980 470 630 1.4E-43 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Gene3D G3DSA:3.40.50.980 1993 2143 1.9E-38 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 Gene3D G3DSA:3.40.50.980 4534 4696 6.7E-49 T 09-03-2017 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 ProSitePatterns PS00455 Putative AMP-binding domain signature. 2122 2133 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 SMART SM00823 Phosphopantetheine attachment site 5055 5123 0.0011 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 SMART SM00823 Phosphopantetheine attachment site 978 1046 0.0027 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 SMART SM00823 Phosphopantetheine attachment site 3540 3608 3.6E-7 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 SMART SM00823 Phosphopantetheine attachment site 2477 2546 2.5E-11 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2501 2516 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS01260 4b1ceea420a7de3133f541ba3cc3b54b 5130 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3564 3579 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS29535 925289682d73b8c494c8c1314a4ace70 311 Gene3D G3DSA:1.10.10.10 19 103 2.1E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS29535 925289682d73b8c494c8c1314a4ace70 311 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 22 78 7.5E-21 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS29535 925289682d73b8c494c8c1314a4ace70 311 SUPERFAMILY SSF46785 16 127 1.42E-24 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS29535 925289682d73b8c494c8c1314a4ace70 311 SUPERFAMILY SSF53850 108 305 1.92E-39 T 09-03-2017 TK78_RS29535 925289682d73b8c494c8c1314a4ace70 311 Gene3D G3DSA:3.40.190.10 190 279 5.3E-19 T 09-03-2017 TK78_RS29535 925289682d73b8c494c8c1314a4ace70 311 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 56 67 2.1E-6 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS29535 925289682d73b8c494c8c1314a4ace70 311 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 35 46 2.1E-6 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS29535 925289682d73b8c494c8c1314a4ace70 311 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 46 56 2.1E-6 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS29535 925289682d73b8c494c8c1314a4ace70 311 Pfam PF03466 LysR substrate binding domain 106 306 1.4E-44 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS29535 925289682d73b8c494c8c1314a4ace70 311 Gene3D G3DSA:3.40.190.10 109 189 3.7E-16 T 09-03-2017 TK78_RS16355 0072351009b6977ac3b23c7015135dd5 273 SUPERFAMILY SSF53850 55 272 1.4E-53 T 09-03-2017 TK78_RS16355 0072351009b6977ac3b23c7015135dd5 273 Gene3D G3DSA:3.40.190.10 53 179 1.7E-35 T 09-03-2017 TK78_RS16355 0072351009b6977ac3b23c7015135dd5 273 Gene3D G3DSA:3.40.190.10 190 264 3.0E-7 T 09-03-2017 TK78_RS16355 0072351009b6977ac3b23c7015135dd5 273 PIRSF PIRSF004846 7 273 2.0E-63 T 09-03-2017 IPR005950 Molybdenum ABC transporter, periplasmic binding protein GO:0015412|GO:0015689|GO:0030288 TK78_RS16355 0072351009b6977ac3b23c7015135dd5 273 TIGRFAM TIGR01256 modA: molybdate ABC transporter, periplasmic molybdate-binding protein 61 267 9.0E-40 T 09-03-2017 IPR005950 Molybdenum ABC transporter, periplasmic binding protein GO:0015412|GO:0015689|GO:0030288 TK78_RS16355 0072351009b6977ac3b23c7015135dd5 273 Pfam PF13531 Bacterial extracellular solute-binding protein 56 271 4.3E-48 T 09-03-2017 TK78_RS25375 c524b6192636ba05f0e99d16c7d54896 725 Gene3D G3DSA:2.60.120.260 272 393 2.9E-34 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS25375 c524b6192636ba05f0e99d16c7d54896 725 SMART SM00606 265 393 6.9E-32 T 09-03-2017 IPR006584 Cellulose binding, type IV GO:0030246 TK78_RS25375 c524b6192636ba05f0e99d16c7d54896 725 Gene3D G3DSA:3.40.50.880 35 257 2.4E-47 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS25375 c524b6192636ba05f0e99d16c7d54896 725 Pfam PF03422 Carbohydrate binding module (family 6) 273 393 1.2E-29 T 09-03-2017 IPR005084 Carbohydrate binding module family 6 GO:0030246 TK78_RS25375 c524b6192636ba05f0e99d16c7d54896 725 Pfam PF06283 Trehalose utilisation 39 250 1.7E-80 T 09-03-2017 IPR029010 ThuA-like domain TK78_RS25375 c524b6192636ba05f0e99d16c7d54896 725 Pfam PF16317 Glycosyl hydrolase family 99 404 718 2.8E-55 T 09-03-2017 IPR026071 Glycosyl hydrolase family 99 TK78_RS25375 c524b6192636ba05f0e99d16c7d54896 725 SUPERFAMILY SSF52317 37 261 7.78E-51 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS25375 c524b6192636ba05f0e99d16c7d54896 725 SUPERFAMILY SSF49785 271 393 8.33E-25 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS28925 51389311722e96cf3824977563d4f6b3 497 Gene3D G3DSA:3.10.180.10 365 491 2.4E-34 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS28925 51389311722e96cf3824977563d4f6b3 497 SUPERFAMILY SSF53335 6 163 6.33E-37 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS28925 51389311722e96cf3824977563d4f6b3 497 Gene3D G3DSA:3.90.79.10 197 317 1.2E-21 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS28925 51389311722e96cf3824977563d4f6b3 497 SUPERFAMILY SSF55811 195 322 4.33E-22 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS28925 51389311722e96cf3824977563d4f6b3 497 Gene3D G3DSA:3.40.50.150 31 161 7.7E-33 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS28925 51389311722e96cf3824977563d4f6b3 497 Pfam PF13669 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 369 478 1.0E-14 T 09-03-2017 TK78_RS28925 51389311722e96cf3824977563d4f6b3 497 Pfam PF00293 NUDIX domain 205 316 2.6E-13 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS28925 51389311722e96cf3824977563d4f6b3 497 Pfam PF08241 Methyltransferase domain 46 139 1.3E-20 T 09-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 TK78_RS28925 51389311722e96cf3824977563d4f6b3 497 SUPERFAMILY SSF54593 366 494 2.69E-18 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SUPERFAMILY SSF52777 10 184 8.45E-33 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Pfam PF13193 AMP-binding enzyme C-terminal domain 5135 5210 4.1E-7 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Pfam PF13193 AMP-binding enzyme C-terminal domain 3043 3114 5.3E-6 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Pfam PF13193 AMP-binding enzyme C-terminal domain 1979 2059 2.6E-8 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Pfam PF13193 AMP-binding enzyme C-terminal domain 4097 4174 1.5E-10 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Pfam PF13193 AMP-binding enzyme C-terminal domain 901 996 7.3E-14 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 ProSitePatterns PS00455 Putative AMP-binding domain signature. 643 654 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Pfam PF00550 Phosphopantetheine attachment site 1025 1084 5.8E-12 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Pfam PF00550 Phosphopantetheine attachment site 3146 3209 1.5E-13 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Pfam PF00550 Phosphopantetheine attachment site 2086 2147 6.2E-11 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Pfam PF00550 Phosphopantetheine attachment site 4201 4260 2.2E-10 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Pfam PF00550 Phosphopantetheine attachment site 5237 5299 9.4E-11 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 ProSitePatterns PS00012 Phosphopantetheine attachment site. 4223 4238 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:3.40.50.980 1573 1728 1.0E-39 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:3.40.50.980 3685 3851 1.8E-41 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:3.40.50.980 4733 4898 3.3E-44 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:3.40.50.980 628 662 8.3E-41 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:3.40.50.980 476 586 8.3E-41 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 ProSitePatterns PS00455 Putative AMP-binding domain signature. 2774 2785 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SUPERFAMILY SSF52777 4467 4709 1.11E-52 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:2.30.38.10 806 882 2.0E-23 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:2.30.38.10 5037 5113 6.0E-24 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:2.30.38.10 2946 3025 4.3E-24 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:2.30.38.10 4000 4077 8.6E-21 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:2.30.38.10 1884 1961 6.1E-20 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 ProSitePatterns PS00455 Putative AMP-binding domain signature. 3830 3841 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3168 3183 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SUPERFAMILY SSF47336 1015 1087 6.15E-17 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SUPERFAMILY SSF56801 3651 4210 1.96E-147 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SUPERFAMILY SSF52777 1303 1549 1.33E-56 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SUPERFAMILY SSF52777 1114 1298 3.34E-39 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SUPERFAMILY SSF47336 4192 4260 1.44E-14 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 ProSitePatterns PS00455 Putative AMP-binding domain signature. 4877 4888 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Pfam PF00501 AMP-binding enzyme 479 893 9.2E-95 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Pfam PF00501 AMP-binding enzyme 4739 5124 8.5E-88 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Pfam PF00501 AMP-binding enzyme 1578 1971 5.0E-91 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Pfam PF00501 AMP-binding enzyme 2624 3035 1.3E-96 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Pfam PF00501 AMP-binding enzyme 3692 4089 6.2E-89 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SUPERFAMILY SSF52777 2164 2358 1.56E-42 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SUPERFAMILY SSF52777 5503 5769 1.56E-26 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Pfam PF13745 HxxPF-repeated domain 3547 3638 1.3E-24 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Pfam PF13745 HxxPF-repeated domain 2479 2570 2.6E-21 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Pfam PF13745 HxxPF-repeated domain 1438 1530 2.0E-21 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Pfam PF00668 Condensation domain 2168 2457 2.8E-61 T 09-03-2017 IPR001242 Condensation domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Pfam PF00668 Condensation domain 3232 3524 2.0E-57 T 09-03-2017 IPR001242 Condensation domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Pfam PF00668 Condensation domain 6 301 1.2E-34 T 09-03-2017 IPR001242 Condensation domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Pfam PF00668 Condensation domain 5320 5621 8.4E-32 T 09-03-2017 IPR001242 Condensation domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Pfam PF00668 Condensation domain 4287 4579 1.2E-52 T 09-03-2017 IPR001242 Condensation domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Pfam PF00668 Condensation domain 1113 1415 4.4E-50 T 09-03-2017 IPR001242 Condensation domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SUPERFAMILY SSF56801 1567 2097 5.36E-140 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 2645 3059 6.3E-127 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 1597 1995 1.8E-122 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 4760 5148 4.7E-122 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 500 917 9.4E-121 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 3712 4113 1.9E-124 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SUPERFAMILY SSF52777 5319 5512 1.78E-27 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1046 1061 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 ProSitePatterns PS00455 Putative AMP-binding domain signature. 1719 1730 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SUPERFAMILY SSF47336 2077 2147 2.09E-16 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SUPERFAMILY SSF52777 3414 3661 5.67E-56 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:3.40.50.980 2620 2779 5.0E-46 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SUPERFAMILY SSF52777 194 429 1.22E-36 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SUPERFAMILY SSF47336 5229 5299 2.88E-16 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SUPERFAMILY SSF52777 3228 3425 4.89E-43 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SUPERFAMILY SSF56801 435 1034 1.44E-144 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 ProSitePatterns PS00012 Phosphopantetheine attachment site. 5259 5274 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:1.10.1200.10 4204 4267 7.8E-22 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:1.10.1200.10 3146 3212 2.0E-22 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:1.10.1200.10 5240 5303 2.5E-23 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:1.10.1200.10 1025 1092 1.5E-22 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:1.10.1200.10 2089 2148 1.9E-21 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:3.40.50.980 4899 5036 4.8E-35 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:3.40.50.980 3852 3999 2.1E-45 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:3.40.50.980 663 805 6.0E-34 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SUPERFAMILY SSF52777 2345 2609 4.67E-58 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SUPERFAMILY SSF47336 3137 3246 7.72E-18 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SUPERFAMILY SSF56801 4700 5247 4.84E-146 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SUPERFAMILY SSF56801 2584 3155 7.06E-147 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:3.40.50.980 2780 2945 1.1E-41 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:3.40.50.980 1729 1883 1.3E-36 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SMART SM00823 Phosphopantetheine attachment site 4196 4267 0.0076 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SMART SM00823 Phosphopantetheine attachment site 2084 2153 8.2E-4 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SMART SM00823 Phosphopantetheine attachment site 1022 1091 1.3E-5 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SMART SM00823 Phosphopantetheine attachment site 3143 3213 1.7E-8 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SMART SM00823 Phosphopantetheine attachment site 5235 5303 7.1E-7 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 SUPERFAMILY SSF52777 4286 4481 5.0E-36 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2108 2123 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:3.30.300.30 888 1024 3.5E-34 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:3.30.300.30 4084 4203 5.3E-35 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:3.30.300.30 1966 2088 3.4E-32 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:3.30.300.30 5119 5239 3.5E-34 T 09-03-2017 TK78_RS01270 af14db04ab19565ab9c454a44a1ac569 5822 Gene3D G3DSA:3.30.300.30 3031 3145 2.4E-27 T 09-03-2017 TK78_RS16650 796089e5601f67fce7c5e549f63ca43c 723 Pfam PF13231 Dolichyl-phosphate-mannose-protein mannosyltransferase 80 234 1.2E-27 T 09-03-2017 TK78_RS23920 f65a0004b10502c4c4d93845b2783776 167 Pfam PF04978 Protein of unknown function (DUF664) 11 163 3.2E-45 T 09-03-2017 IPR007061 Protein of unknown function DUF664 TK78_RS23920 f65a0004b10502c4c4d93845b2783776 167 SUPERFAMILY SSF109854 2 162 1.3E-42 T 09-03-2017 TK78_RS23920 f65a0004b10502c4c4d93845b2783776 167 Gene3D G3DSA:1.20.120.450 2 166 1.0E-46 T 09-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase TK78_RS09275 aa01d0d665636c7f4bf67c7732f76609 270 PIRSF PIRSF006648 3 264 1.8E-17 T 09-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 TK78_RS09275 aa01d0d665636c7f4bf67c7732f76609 270 Pfam PF01061 ABC-2 type transporter 30 234 9.5E-24 T 09-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 TK78_RS20965 32b620ca2816a18c06e4ca9d09967ac2 406 Gene3D G3DSA:2.40.10.10 204 281 1.0E-10 T 09-03-2017 TK78_RS20965 32b620ca2816a18c06e4ca9d09967ac2 406 Gene3D G3DSA:3.30.300.50 125 194 1.2E-16 T 09-03-2017 TK78_RS20965 32b620ca2816a18c06e4ca9d09967ac2 406 Gene3D G3DSA:3.30.300.50 46 122 9.2E-8 T 09-03-2017 TK78_RS20965 32b620ca2816a18c06e4ca9d09967ac2 406 SUPERFAMILY SSF50494 207 403 1.76E-23 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS20965 32b620ca2816a18c06e4ca9d09967ac2 406 Gene3D G3DSA:2.40.10.10 288 399 8.5E-21 T 09-03-2017 TK78_RS20965 32b620ca2816a18c06e4ca9d09967ac2 406 Pfam PF02983 Alpha-lytic protease prodomain 128 183 2.1E-12 T 09-03-2017 IPR004236 Peptidase S1A, alpha-lytic prodomain GO:0005576|GO:0006508|GO:0008236 TK78_RS20965 32b620ca2816a18c06e4ca9d09967ac2 406 PIRSF PIRSF001134 1 406 4.6E-65 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS20965 32b620ca2816a18c06e4ca9d09967ac2 406 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 339 362 8.4E-13 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS20965 32b620ca2816a18c06e4ca9d09967ac2 406 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 229 243 8.4E-13 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS20965 32b620ca2816a18c06e4ca9d09967ac2 406 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 363 377 8.4E-13 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS32005 21d1c14ef8461045a4abe9f028fdfa16 297 Pfam PF01758 Sodium Bile acid symporter family 11 193 3.4E-30 T 09-03-2017 IPR002657 Bile acid:sodium symporter/arsenical resistance protein Acr3 GO:0016020 TK78_RS04185 24646606b7244ec4c79099439a7566c8 343 Gene3D G3DSA:3.80.30.20 62 267 4.0E-8 T 09-03-2017 IPR023404 Radical SAM, alpha/beta horseshoe TK78_RS04185 24646606b7244ec4c79099439a7566c8 343 Pfam PF04055 Radical SAM superfamily 63 234 6.1E-10 T 09-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 TK78_RS04185 24646606b7244ec4c79099439a7566c8 343 SMART SM00729 59 288 0.0074 T 09-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 TK78_RS04185 24646606b7244ec4c79099439a7566c8 343 SUPERFAMILY SSF102114 62 284 3.14E-13 T 09-03-2017 TK78_RS02605 42750e47136ec380a4b5cdd057783930 404 SMART SM00922 128 259 1.2E-17 T 09-03-2017 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal TK78_RS02605 42750e47136ec380a4b5cdd057783930 404 Gene3D G3DSA:3.30.390.10 8 116 1.6E-41 T 09-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS02605 42750e47136ec380a4b5cdd057783930 404 Pfam PF02746 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain 14 110 2.0E-30 T 09-03-2017 IPR013341 Mandelate racemase/muconate lactonizing enzyme, N-terminal domain TK78_RS02605 42750e47136ec380a4b5cdd057783930 404 SUPERFAMILY SSF54826 1 112 3.68E-32 T 09-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS02605 42750e47136ec380a4b5cdd057783930 404 Gene3D G3DSA:3.20.20.120 117 367 5.6E-81 T 09-03-2017 IPR029065 Enolase C-terminal domain-like TK78_RS02605 42750e47136ec380a4b5cdd057783930 404 Pfam PF13378 Enolase C-terminal domain-like 133 379 1.9E-42 T 09-03-2017 IPR029065 Enolase C-terminal domain-like TK78_RS02605 42750e47136ec380a4b5cdd057783930 404 ProSitePatterns PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. 85 110 - T 09-03-2017 IPR018110 Mandelate racemase/muconate lactonizing enzyme, conserved site GO:0009063 TK78_RS02605 42750e47136ec380a4b5cdd057783930 404 SUPERFAMILY SSF51604 98 386 3.96E-73 T 09-03-2017 IPR029065 Enolase C-terminal domain-like TK78_RS22755 8ef2581ab568f366434590025c112592 273 Gene3D G3DSA:3.40.50.1820 17 269 1.3E-51 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS22755 8ef2581ab568f366434590025c112592 273 Pfam PF12697 Alpha/beta hydrolase family 31 259 1.0E-21 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS22755 8ef2581ab568f366434590025c112592 273 SUPERFAMILY SSF53474 16 269 6.3E-50 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS22755 8ef2581ab568f366434590025c112592 273 PRINTS PR00111 Alpha/beta hydrolase fold signature 114 127 7.8E-9 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS22755 8ef2581ab568f366434590025c112592 273 PRINTS PR00111 Alpha/beta hydrolase fold signature 54 69 7.8E-9 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS22755 8ef2581ab568f366434590025c112592 273 PRINTS PR00111 Alpha/beta hydrolase fold signature 215 229 7.8E-9 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS22755 8ef2581ab568f366434590025c112592 273 PRINTS PR00111 Alpha/beta hydrolase fold signature 100 113 7.8E-9 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS08330 c8f199b96182ee79f60421b33f222759 391 Pfam PF07478 D-ala D-ala ligase C-terminus 176 381 2.9E-65 T 09-03-2017 IPR011095 D-alanine--D-alanine ligase, C-terminal GO:0008716 KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS08330 c8f199b96182ee79f60421b33f222759 391 Gene3D G3DSA:3.40.50.20 22 155 4.9E-37 T 09-03-2017 IPR016185 Pre-ATP-grasp domain TK78_RS08330 c8f199b96182ee79f60421b33f222759 391 SUPERFAMILY SSF56059 166 386 3.36E-54 T 09-03-2017 TK78_RS08330 c8f199b96182ee79f60421b33f222759 391 PIRSF PIRSF039102 20 390 2.5E-108 T 09-03-2017 IPR005905 D-alanine--D-alanine ligase GO:0005737|GO:0008716 KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS08330 c8f199b96182ee79f60421b33f222759 391 Pfam PF01820 D-ala D-ala ligase N-terminus 24 156 4.2E-34 T 09-03-2017 IPR011127 D-alanine--D-alanine ligase, N-terminal domain KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS08330 c8f199b96182ee79f60421b33f222759 391 Gene3D G3DSA:3.30.470.20 256 387 1.6E-47 T 09-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 TK78_RS08330 c8f199b96182ee79f60421b33f222759 391 SUPERFAMILY SSF52440 22 164 2.01E-34 T 09-03-2017 IPR016185 Pre-ATP-grasp domain TK78_RS08330 c8f199b96182ee79f60421b33f222759 391 Gene3D G3DSA:3.30.1490.20 177 254 3.9E-20 T 09-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 TK78_RS08330 c8f199b96182ee79f60421b33f222759 391 Hamap MF_00047 D-alanine--D-alanine ligase [ddl]. 23 384 41.146 T 09-03-2017 IPR005905 D-alanine--D-alanine ligase GO:0005737|GO:0008716 KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS08330 c8f199b96182ee79f60421b33f222759 391 ProSitePatterns PS00843 D-alanine--D-alanine ligase signature 1. 133 144 - T 09-03-2017 IPR000291 D-alanine--D-alanine ligase/VANA/B/C, conserved site KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS08330 c8f199b96182ee79f60421b33f222759 391 ProSitePatterns PS00844 D-alanine--D-alanine ligase signature 2. 326 354 - T 09-03-2017 IPR000291 D-alanine--D-alanine ligase/VANA/B/C, conserved site KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS08330 c8f199b96182ee79f60421b33f222759 391 TIGRFAM TIGR01205 D_ala_D_alaTIGR: D-alanine--D-alanine ligase 24 383 6.8E-103 T 09-03-2017 IPR005905 D-alanine--D-alanine ligase GO:0005737|GO:0008716 KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS23195 93d555ca58b5ee43b3ad4e0ef77ca499 558 TIGRFAM TIGR01625 YidE_YbjL_dupl: AspT/YidE/YbjL antiporter duplication domain 390 540 2.4E-27 T 09-03-2017 IPR006512 YidE/YbjL duplication TK78_RS23195 93d555ca58b5ee43b3ad4e0ef77ca499 558 TIGRFAM TIGR03802 Asp_Ala_antiprt: aspartate-alanine antiporter 2 555 1.4E-218 T 09-03-2017 IPR022457 Aspartate-alanine antiporter GO:0005215|GO:0016020 TK78_RS23195 93d555ca58b5ee43b3ad4e0ef77ca499 558 Gene3D G3DSA:3.30.70.1450 301 375 3.1E-7 T 09-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 TK78_RS23195 93d555ca58b5ee43b3ad4e0ef77ca499 558 Gene3D G3DSA:3.30.70.1450 226 285 2.5E-4 T 09-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 TK78_RS23195 93d555ca58b5ee43b3ad4e0ef77ca499 558 SUPERFAMILY SSF116726 295 376 3.66E-8 T 09-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 TK78_RS23195 93d555ca58b5ee43b3ad4e0ef77ca499 558 SUPERFAMILY SSF116726 226 284 1.23E-5 T 09-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 TK78_RS23195 93d555ca58b5ee43b3ad4e0ef77ca499 558 Pfam PF02080 TrkA-C domain 324 371 3.5E-7 T 09-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 TK78_RS23195 93d555ca58b5ee43b3ad4e0ef77ca499 558 Pfam PF06826 Predicted Permease Membrane Region 386 552 2.0E-33 T 09-03-2017 IPR006512 YidE/YbjL duplication TK78_RS23195 93d555ca58b5ee43b3ad4e0ef77ca499 558 Pfam PF06826 Predicted Permease Membrane Region 11 175 3.1E-28 T 09-03-2017 IPR006512 YidE/YbjL duplication TK78_RS20390 d02e176550a3b7275e4d5c08e6db574f 215 SUPERFAMILY SSF46689 1 76 1.28E-13 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS20390 d02e176550a3b7275e4d5c08e6db574f 215 Pfam PF00440 Bacterial regulatory proteins, tetR family 17 58 1.6E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS20390 d02e176550a3b7275e4d5c08e6db574f 215 SUPERFAMILY SSF48498 88 200 7.59E-17 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS20390 d02e176550a3b7275e4d5c08e6db574f 215 Gene3D G3DSA:1.10.357.10 1 203 1.2E-40 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS20390 d02e176550a3b7275e4d5c08e6db574f 215 Pfam PF13977 Bacterial transcriptional repressor 88 200 2.9E-22 T 09-03-2017 TK78_RS00505 ad19f09aaa9e855ca22c0144e149c01d 90 Pfam PF11625 Protein of unknown function (DUF3253) 11 88 4.6E-31 T 09-03-2017 IPR021660 Protein of unknown function DUF3253 TK78_RS00505 ad19f09aaa9e855ca22c0144e149c01d 90 SUPERFAMILY SSF46785 10 89 1.25E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS00505 ad19f09aaa9e855ca22c0144e149c01d 90 Gene3D G3DSA:1.10.10.10 9 89 5.4E-33 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS11410 b46cd340143e0190c02ca1d967ed3063 1056 Gene3D G3DSA:3.40.47.10 281 453 2.0E-50 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS11410 b46cd340143e0190c02ca1d967ed3063 1056 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 404 516 1.5E-11 T 09-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS11410 b46cd340143e0190c02ca1d967ed3063 1056 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 276 401 1.1E-32 T 09-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal TK78_RS11410 b46cd340143e0190c02ca1d967ed3063 1056 Pfam PF00550 Phosphopantetheine attachment site 912 978 2.1E-11 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS11410 b46cd340143e0190c02ca1d967ed3063 1056 Gene3D G3DSA:1.10.1200.10 909 982 1.4E-14 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS11410 b46cd340143e0190c02ca1d967ed3063 1056 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 180 196 - T 09-03-2017 IPR018201 Beta-ketoacyl synthase, active site TK78_RS11410 b46cd340143e0190c02ca1d967ed3063 1056 SMART SM00825 Beta-ketoacyl synthase 6 453 3.3E-127 T 09-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TK78_RS11410 b46cd340143e0190c02ca1d967ed3063 1056 SUPERFAMILY SSF47336 905 1000 6.41E-15 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS11410 b46cd340143e0190c02ca1d967ed3063 1056 Pfam PF00698 Acyl transferase domain 555 812 1.2E-36 T 09-03-2017 IPR014043 Acyl transferase TK78_RS11410 b46cd340143e0190c02ca1d967ed3063 1056 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 4 267 3.8E-56 T 09-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal TK78_RS11410 b46cd340143e0190c02ca1d967ed3063 1056 SUPERFAMILY SSF52151 745 838 4.19E-52 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS11410 b46cd340143e0190c02ca1d967ed3063 1056 SUPERFAMILY SSF52151 555 682 4.19E-52 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS11410 b46cd340143e0190c02ca1d967ed3063 1056 Gene3D G3DSA:3.40.47.10 6 280 2.1E-61 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS11410 b46cd340143e0190c02ca1d967ed3063 1056 ProSitePatterns PS00012 Phosphopantetheine attachment site. 937 952 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS11410 b46cd340143e0190c02ca1d967ed3063 1056 SUPERFAMILY SSF53901 163 397 4.05E-70 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS11410 b46cd340143e0190c02ca1d967ed3063 1056 SUPERFAMILY SSF53901 428 449 4.05E-70 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS11410 b46cd340143e0190c02ca1d967ed3063 1056 SUPERFAMILY SSF53901 2 124 4.05E-70 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS11410 b46cd340143e0190c02ca1d967ed3063 1056 SMART SM00823 Phosphopantetheine attachment site 911 983 4.4E-5 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS11410 b46cd340143e0190c02ca1d967ed3063 1056 Gene3D G3DSA:3.40.366.10 551 676 5.1E-51 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS11410 b46cd340143e0190c02ca1d967ed3063 1056 Gene3D G3DSA:3.40.366.10 743 842 5.1E-51 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS11410 b46cd340143e0190c02ca1d967ed3063 1056 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 557 855 5.3E-58 T 09-03-2017 IPR020801 Polyketide synthase, acyl transferase domain TK78_RS11410 b46cd340143e0190c02ca1d967ed3063 1056 SUPERFAMILY SSF55048 681 744 1.22E-6 T 09-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 SMART SM00823 Phosphopantetheine attachment site 968 1036 7.2E-7 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 SUPERFAMILY SSF56801 426 981 4.84E-143 T 09-03-2017 TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 ProSitePatterns PS00012 Phosphopantetheine attachment site. 992 1007 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 Gene3D G3DSA:3.30.300.30 855 971 2.2E-35 T 09-03-2017 TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 SUPERFAMILY SSF52777 1237 1506 7.23E-29 T 09-03-2017 TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 Pfam PF00501 AMP-binding enzyme 1990 2098 2.1E-26 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 Pfam PF00501 AMP-binding enzyme 464 860 2.1E-86 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 Pfam PF13193 AMP-binding enzyme C-terminal domain 868 943 2.6E-11 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 Gene3D G3DSA:2.30.38.10 773 850 3.3E-23 T 09-03-2017 TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 SUPERFAMILY SSF47336 962 1030 4.71E-17 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 Gene3D G3DSA:1.10.1200.10 972 1035 4.4E-23 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 Pfam PF00550 Phosphopantetheine attachment site 970 1030 3.7E-13 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 SUPERFAMILY SSF52777 1043 1250 2.0E-32 T 09-03-2017 TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 SUPERFAMILY SSF56801 1950 2098 2.88E-36 T 09-03-2017 TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 SUPERFAMILY SSF52777 10 203 6.45E-41 T 09-03-2017 TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 ProSitePatterns PS00455 Putative AMP-binding domain signature. 613 624 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 485 883 6.2E-123 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 SUPERFAMILY SSF52777 1536 1729 9.23E-42 T 09-03-2017 TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 TIGRFAM TIGR01720 NRPS-para261: non-ribosomal peptide synthase domain TIGR01720 1374 1530 1.5E-44 T 09-03-2017 IPR010060 Non-ribosomal peptide synthase TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 SUPERFAMILY SSF52777 1715 1953 1.22E-56 T 09-03-2017 TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 Pfam PF00668 Condensation domain 1069 1358 2.4E-37 T 09-03-2017 IPR001242 Condensation domain TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 Pfam PF00668 Condensation domain 1539 1828 5.7E-61 T 09-03-2017 IPR001242 Condensation domain TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 Pfam PF00668 Condensation domain 12 302 9.1E-65 T 09-03-2017 IPR001242 Condensation domain TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 Gene3D G3DSA:3.40.50.980 461 622 5.0E-48 T 09-03-2017 TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 Gene3D G3DSA:3.40.50.980 1985 2095 1.5E-36 T 09-03-2017 TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 Gene3D G3DSA:3.40.50.980 623 772 8.5E-27 T 09-03-2017 TK78_RS06775 a02a94109847a732cec3aa32ced84370 2105 SUPERFAMILY SSF52777 189 428 6.11E-58 T 09-03-2017 TK78_RS19790 5387cdcdd0c66a32b29ab4cff4a746fe 111 Pfam PF11774 Lsr2 2 109 6.9E-40 T 09-03-2017 IPR024412 Lsr2 TK78_RS19790 5387cdcdd0c66a32b29ab4cff4a746fe 111 ProDom PD026347 LSR2-LIKE LSR2 ANTIGEN IMMUNE PRECURSOR RESPONSE SIGNAL PLASMID LYSYL GP61 1 110 4.0E-29 T 09-03-2017 IPR024412 Lsr2 TK78_RS04755 35064bbc28e78c6731afb6b27b165994 247 ProSitePatterns PS00211 ABC transporters family signature. 142 156 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS04755 35064bbc28e78c6731afb6b27b165994 247 SUPERFAMILY SSF52540 6 240 4.28E-79 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS04755 35064bbc28e78c6731afb6b27b165994 247 Gene3D G3DSA:3.40.50.300 5 242 9.0E-83 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS04755 35064bbc28e78c6731afb6b27b165994 247 Pfam PF00005 ABC transporter 22 170 1.6E-36 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS04755 35064bbc28e78c6731afb6b27b165994 247 SMART SM00382 31 218 1.3E-18 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS04755 35064bbc28e78c6731afb6b27b165994 247 PIRSF PIRSF039085 3 246 5.0E-109 T 09-03-2017 IPR030679 ABC-type amino acid transport system, ATPase component, HisP-type GO:0003333|GO:0015424 TK78_RS32470 a44aa9161e0bf55c161163ed72281e2b 401 Pfam PF13556 PucR C-terminal helix-turn-helix domain 331 389 8.9E-17 T 09-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain TK78_RS32945 465478aeea033b20eaa2ee1beb2b72c3 439 Gene3D G3DSA:3.40.190.10 46 165 2.1E-13 T 09-03-2017 TK78_RS32945 465478aeea033b20eaa2ee1beb2b72c3 439 Gene3D G3DSA:3.40.190.10 166 339 1.8E-31 T 09-03-2017 TK78_RS32945 465478aeea033b20eaa2ee1beb2b72c3 439 SUPERFAMILY SSF53850 45 424 1.52E-52 T 09-03-2017 TK78_RS32945 465478aeea033b20eaa2ee1beb2b72c3 439 Pfam PF13416 Bacterial extracellular solute-binding protein 55 334 3.6E-28 T 09-03-2017 TK78_RS13060 c3f50369c11dda0f72a4cf2cfa8e8fc1 437 Gene3D G3DSA:1.10.3370.10 2 437 4.9E-158 T 09-03-2017 IPR023201 SecY subunit domain Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 TK78_RS13060 c3f50369c11dda0f72a4cf2cfa8e8fc1 437 ProSitePatterns PS00755 Protein secY signature 1. 72 91 - T 09-03-2017 IPR030659 SecY conserved site Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 TK78_RS13060 c3f50369c11dda0f72a4cf2cfa8e8fc1 437 SUPERFAMILY SSF103491 2 427 7.72E-126 T 09-03-2017 IPR023201 SecY subunit domain Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 TK78_RS13060 c3f50369c11dda0f72a4cf2cfa8e8fc1 437 Hamap MF_01465 Protein translocase subunit SecY [secY]. 5 436 29.526 T 09-03-2017 IPR026593 Protein translocase subunit SecY TK78_RS13060 c3f50369c11dda0f72a4cf2cfa8e8fc1 437 PIRSF PIRSF004557 1 437 1.9E-122 T 09-03-2017 IPR002208 SecY/SEC61-alpha family GO:0015031|GO:0016020 Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 TK78_RS13060 c3f50369c11dda0f72a4cf2cfa8e8fc1 437 Pfam PF00344 SecY translocase 72 420 7.1E-117 T 09-03-2017 IPR002208 SecY/SEC61-alpha family GO:0015031|GO:0016020 Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 TK78_RS13060 c3f50369c11dda0f72a4cf2cfa8e8fc1 437 ProSitePatterns PS00756 Protein secY signature 2. 175 192 - T 09-03-2017 IPR030659 SecY conserved site Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 TK78_RS13060 c3f50369c11dda0f72a4cf2cfa8e8fc1 437 TIGRFAM TIGR00967 3a0501s007: preprotein translocase, SecY subunit 15 432 7.9E-151 T 09-03-2017 IPR002208 SecY/SEC61-alpha family GO:0015031|GO:0016020 Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 TK78_RS13060 c3f50369c11dda0f72a4cf2cfa8e8fc1 437 PRINTS PR00303 Preprotein translocase SecY subunit signature 18 36 9.0E-106 T 09-03-2017 TK78_RS13060 c3f50369c11dda0f72a4cf2cfa8e8fc1 437 PRINTS PR00303 Preprotein translocase SecY subunit signature 315 337 9.0E-106 T 09-03-2017 TK78_RS13060 c3f50369c11dda0f72a4cf2cfa8e8fc1 437 PRINTS PR00303 Preprotein translocase SecY subunit signature 370 388 9.0E-106 T 09-03-2017 TK78_RS13060 c3f50369c11dda0f72a4cf2cfa8e8fc1 437 PRINTS PR00303 Preprotein translocase SecY subunit signature 71 91 9.0E-106 T 09-03-2017 TK78_RS13060 c3f50369c11dda0f72a4cf2cfa8e8fc1 437 PRINTS PR00303 Preprotein translocase SecY subunit signature 156 181 9.0E-106 T 09-03-2017 TK78_RS13060 c3f50369c11dda0f72a4cf2cfa8e8fc1 437 PRINTS PR00303 Preprotein translocase SecY subunit signature 112 135 9.0E-106 T 09-03-2017 TK78_RS13060 c3f50369c11dda0f72a4cf2cfa8e8fc1 437 PRINTS PR00303 Preprotein translocase SecY subunit signature 182 205 9.0E-106 T 09-03-2017 TK78_RS13060 c3f50369c11dda0f72a4cf2cfa8e8fc1 437 PRINTS PR00303 Preprotein translocase SecY subunit signature 273 292 9.0E-106 T 09-03-2017 TK78_RS13060 c3f50369c11dda0f72a4cf2cfa8e8fc1 437 PRINTS PR00303 Preprotein translocase SecY subunit signature 405 423 9.0E-106 T 09-03-2017 TK78_RS10300 15d54584f141fb579c7867ede5dec080 254 Pfam PF00392 Bacterial regulatory proteins, gntR family 35 84 5.7E-17 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS10300 15d54584f141fb579c7867ede5dec080 254 SUPERFAMILY SSF46785 18 88 7.88E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS10300 15d54584f141fb579c7867ede5dec080 254 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 44 58 2.6E-8 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS10300 15d54584f141fb579c7867ede5dec080 254 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 58 74 2.6E-8 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS10300 15d54584f141fb579c7867ede5dec080 254 Gene3D G3DSA:3.40.1410.10 82 251 1.6E-55 T 09-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain TK78_RS10300 15d54584f141fb579c7867ede5dec080 254 SMART SM00866 104 244 4.3E-43 T 09-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 TK78_RS10300 15d54584f141fb579c7867ede5dec080 254 Pfam PF07702 UTRA domain 104 244 5.3E-42 T 09-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 TK78_RS10300 15d54584f141fb579c7867ede5dec080 254 SMART SM00345 27 84 3.1E-15 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS10300 15d54584f141fb579c7867ede5dec080 254 Gene3D G3DSA:1.10.10.10 18 81 6.8E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS10300 15d54584f141fb579c7867ede5dec080 254 SUPERFAMILY SSF64288 72 251 1.32E-54 T 09-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain TK78_RS28460 fdd2b7230893ac347533a47020757afa 871 Pfam PF01061 ABC-2 type transporter 596 806 1.8E-18 T 09-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 TK78_RS28460 fdd2b7230893ac347533a47020757afa 871 SUPERFAMILY SSF49879 157 313 9.56E-29 T 09-03-2017 IPR008984 SMAD/FHA domain GO:0005515 TK78_RS28460 fdd2b7230893ac347533a47020757afa 871 Pfam PF00498 FHA domain 219 285 3.2E-16 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS28460 fdd2b7230893ac347533a47020757afa 871 Pfam PF00498 FHA domain 25 88 1.7E-17 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS28460 fdd2b7230893ac347533a47020757afa 871 SMART SM00382 332 526 3.6E-13 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS28460 fdd2b7230893ac347533a47020757afa 871 Gene3D G3DSA:2.60.200.20 152 308 8.5E-25 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS28460 fdd2b7230893ac347533a47020757afa 871 Gene3D G3DSA:3.40.50.300 309 532 6.8E-68 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28460 fdd2b7230893ac347533a47020757afa 871 Gene3D G3DSA:2.60.200.20 18 91 3.2E-23 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS28460 fdd2b7230893ac347533a47020757afa 871 Pfam PF00005 ABC transporter 323 470 1.8E-31 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS28460 fdd2b7230893ac347533a47020757afa 871 SMART SM00240 24 74 3.6E-12 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS28460 fdd2b7230893ac347533a47020757afa 871 SMART SM00240 217 268 8.0E-14 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS28460 fdd2b7230893ac347533a47020757afa 871 ProSitePatterns PS00211 ABC transporters family signature. 442 456 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS28460 fdd2b7230893ac347533a47020757afa 871 SUPERFAMILY SSF52540 301 539 4.31E-59 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28460 fdd2b7230893ac347533a47020757afa 871 SUPERFAMILY SSF49879 13 90 3.83E-23 T 09-03-2017 IPR008984 SMAD/FHA domain GO:0005515 TK78_RS10690 7230c2578f2256658e7523405a153d58 248 SUPERFAMILY SSF47240 25 246 2.32E-10 T 09-03-2017 IPR009078 Ferritin-like superfamily TK78_RS10690 7230c2578f2256658e7523405a153d58 248 Pfam PF13794 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like 32 216 7.0E-93 T 09-03-2017 TK78_RS10690 7230c2578f2256658e7523405a153d58 248 Gene3D G3DSA:1.20.1260.10 36 160 3.7E-9 T 09-03-2017 IPR012347 Ferritin-related TK78_RS05055 477b9058f81afaee78668a9201f5acca 485 SMART SM01060 7 392 3.9E-278 T 09-03-2017 IPR011614 Catalase core domain GO:0004096|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS05055 477b9058f81afaee78668a9201f5acca 485 PRINTS PR00067 Catalase signature 288 315 5.7E-70 T 09-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS05055 477b9058f81afaee78668a9201f5acca 485 PRINTS PR00067 Catalase signature 104 121 5.7E-70 T 09-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS05055 477b9058f81afaee78668a9201f5acca 485 PRINTS PR00067 Catalase signature 123 141 5.7E-70 T 09-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS05055 477b9058f81afaee78668a9201f5acca 485 PRINTS PR00067 Catalase signature 83 101 5.7E-70 T 09-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS05055 477b9058f81afaee78668a9201f5acca 485 PRINTS PR00067 Catalase signature 20 43 5.7E-70 T 09-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS05055 477b9058f81afaee78668a9201f5acca 485 PRINTS PR00067 Catalase signature 320 346 5.7E-70 T 09-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS05055 477b9058f81afaee78668a9201f5acca 485 PIRSF PIRSF038928 1 485 2.3E-222 T 09-03-2017 IPR024711 Catalase, mono-functional, haem-containing, clades 1 and 3 GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS05055 477b9058f81afaee78668a9201f5acca 485 ProSitePatterns PS00437 Catalase proximal heme-ligand signature. 333 341 - T 09-03-2017 IPR002226 Catalase haem-binding site GO:0020037 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS05055 477b9058f81afaee78668a9201f5acca 485 SUPERFAMILY SSF56634 4 480 1.19E-205 T 09-03-2017 IPR020835 Catalase-like domain GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS05055 477b9058f81afaee78668a9201f5acca 485 ProSitePatterns PS00438 Catalase proximal active site signature. 43 59 - T 09-03-2017 IPR024708 Catalase active site GO:0004096 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS05055 477b9058f81afaee78668a9201f5acca 485 Pfam PF06628 Catalase-related immune-responsive 418 479 3.7E-21 T 09-03-2017 IPR010582 Catalase immune-responsive domain KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS05055 477b9058f81afaee78668a9201f5acca 485 Gene3D G3DSA:2.40.180.10 2 357 2.1E-180 T 09-03-2017 IPR011614 Catalase core domain GO:0004096|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS05055 477b9058f81afaee78668a9201f5acca 485 Pfam PF00199 Catalase 7 388 1.6E-187 T 09-03-2017 IPR011614 Catalase core domain GO:0004096|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS20790 517af26cff54c4fe7885741e94f87085 260 Gene3D G3DSA:3.40.830.10 2 259 7.2E-83 T 09-03-2017 IPR004183 Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B GO:0006725|GO:0008198|GO:0016491 TK78_RS20790 517af26cff54c4fe7885741e94f87085 260 PIRSF PIRSF006157 3 260 6.4E-83 T 09-03-2017 IPR014436 Extradiol aromatic ring-opening dioxygenase, DODA type GO:0008270|GO:0016701|GO:0055114 TK78_RS20790 517af26cff54c4fe7885741e94f87085 260 Pfam PF02900 Catalytic LigB subunit of aromatic ring-opening dioxygenase 29 237 1.3E-39 T 09-03-2017 IPR004183 Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B GO:0006725|GO:0008198|GO:0016491 TK78_RS20790 517af26cff54c4fe7885741e94f87085 260 SUPERFAMILY SSF53213 7 260 1.96E-80 T 09-03-2017 IPR004183 Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B GO:0006725|GO:0008198|GO:0016491 TK78_RS13650 39ae949945d7f97d6c58777ee19f6b6b 440 Hamap MF_01358 NAD(P)H-quinone oxidoreductase subunit H, chloroplastic [ndhH]. 29 440 46.985 T 09-03-2017 IPR022885 NAD(P)H-quinone oxidoreductase subunit D/H GO:0016651|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13650 39ae949945d7f97d6c58777ee19f6b6b 440 TIGRFAM TIGR01962 NuoD: NADH dehydrogenase (quinone), D subunit 38 440 1.6E-174 T 09-03-2017 IPR022885 NAD(P)H-quinone oxidoreductase subunit D/H GO:0016651|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13650 39ae949945d7f97d6c58777ee19f6b6b 440 ProSitePatterns PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature. 75 86 - T 09-03-2017 IPR014029 NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site GO:0016651|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13650 39ae949945d7f97d6c58777ee19f6b6b 440 Pfam PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 155 440 1.9E-113 T 09-03-2017 IPR001135 NADH-quinone oxidoreductase, subunit D GO:0016651|GO:0048038|GO:0051287|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13650 39ae949945d7f97d6c58777ee19f6b6b 440 SUPERFAMILY SSF56762 48 440 4.58E-122 T 09-03-2017 IPR029014 NiFe hydrogenase-like Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13650 39ae949945d7f97d6c58777ee19f6b6b 440 Gene3D G3DSA:1.10.645.10 29 324 3.3E-69 T 09-03-2017 IPR029014 NiFe hydrogenase-like Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13650 39ae949945d7f97d6c58777ee19f6b6b 440 Gene3D G3DSA:1.10.645.10 368 433 3.3E-69 T 09-03-2017 IPR029014 NiFe hydrogenase-like Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS18430 80f2221f89ae972abc3526a833ddc5e5 343 Gene3D G3DSA:2.70.70.10 187 337 5.2E-42 T 09-03-2017 TK78_RS18430 80f2221f89ae972abc3526a833ddc5e5 343 Pfam PF01551 Peptidase family M23 237 332 3.1E-26 T 09-03-2017 IPR016047 Peptidase M23 TK78_RS18430 80f2221f89ae972abc3526a833ddc5e5 343 SUPERFAMILY SSF51261 165 336 1.83E-42 T 09-03-2017 IPR011055 Duplicated hybrid motif TK78_RS32710 5085c01b0dbc596946cc6f4bc324c75b 169 Gene3D G3DSA:2.30.110.10 13 165 2.8E-51 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS32710 5085c01b0dbc596946cc6f4bc324c75b 169 SMART SM00903 23 166 7.9E-47 T 09-03-2017 IPR002563 Flavin reductase like domain GO:0010181 TK78_RS32710 5085c01b0dbc596946cc6f4bc324c75b 169 Pfam PF01613 Flavin reductase like domain 23 167 1.3E-35 T 09-03-2017 IPR002563 Flavin reductase like domain GO:0010181 TK78_RS32710 5085c01b0dbc596946cc6f4bc324c75b 169 SUPERFAMILY SSF50475 16 166 2.06E-41 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS08125 c2b65a03b04100eee627a6bc2fbddd16 162 SUPERFAMILY SSF55811 6 130 3.52E-23 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS08125 c2b65a03b04100eee627a6bc2fbddd16 162 Pfam PF00293 NUDIX domain 6 129 7.9E-21 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS08125 c2b65a03b04100eee627a6bc2fbddd16 162 Gene3D G3DSA:3.90.79.10 6 148 9.7E-29 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS08125 c2b65a03b04100eee627a6bc2fbddd16 162 ProSitePatterns PS00893 Nudix box signature. 41 62 - T 09-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 TK78_RS08125 c2b65a03b04100eee627a6bc2fbddd16 162 PRINTS PR00502 NUDIX hydrolase family signature 36 50 4.4E-6 T 09-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 TK78_RS08125 c2b65a03b04100eee627a6bc2fbddd16 162 PRINTS PR00502 NUDIX hydrolase family signature 50 65 4.4E-6 T 09-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 TK78_RS06710 0ee1dc5f812135884d494c232e8c33dc 773 Pfam PF00672 HAMP domain 686 754 1.4E-10 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS06710 0ee1dc5f812135884d494c232e8c33dc 773 SMART SM00304 705 757 4.2E-6 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS06710 0ee1dc5f812135884d494c232e8c33dc 773 SMART SM00304 351 403 0.48 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS06710 0ee1dc5f812135884d494c232e8c33dc 773 SUPERFAMILY SSF158472 707 754 1.14E-6 T 09-03-2017 TK78_RS21835 58ed516ff6efb013c67a868e03b1d084 385 Gene3D G3DSA:2.40.110.10 128 223 1.5E-40 T 09-03-2017 TK78_RS21835 58ed516ff6efb013c67a868e03b1d084 385 SUPERFAMILY SSF56645 13 247 5.63E-79 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS21835 58ed516ff6efb013c67a868e03b1d084 385 ProSitePatterns PS00072 Acyl-CoA dehydrogenases signature 1. 130 142 - T 09-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 TK78_RS21835 58ed516ff6efb013c67a868e03b1d084 385 Gene3D G3DSA:1.10.540.10 13 124 9.0E-34 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS21835 58ed516ff6efb013c67a868e03b1d084 385 SUPERFAMILY SSF47203 233 384 7.63E-60 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS21835 58ed516ff6efb013c67a868e03b1d084 385 Gene3D G3DSA:1.20.140.10 224 384 3.6E-71 T 09-03-2017 TK78_RS21835 58ed516ff6efb013c67a868e03b1d084 385 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 235 384 4.1E-52 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS21835 58ed516ff6efb013c67a868e03b1d084 385 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 128 223 3.6E-27 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS21835 58ed516ff6efb013c67a868e03b1d084 385 ProSitePatterns PS00073 Acyl-CoA dehydrogenases signature 2. 343 362 - T 09-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 TK78_RS21835 58ed516ff6efb013c67a868e03b1d084 385 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 14 124 5.6E-30 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS10070 5ff1d03722d1fd800289242ff34adc50 254 Pfam PF00005 ABC transporter 21 179 1.3E-32 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS10070 5ff1d03722d1fd800289242ff34adc50 254 SMART SM00382 30 227 6.3E-16 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS10070 5ff1d03722d1fd800289242ff34adc50 254 SUPERFAMILY SSF52540 5 249 1.02E-78 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10070 5ff1d03722d1fd800289242ff34adc50 254 ProSitePatterns PS00211 ABC transporters family signature. 151 165 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS10070 5ff1d03722d1fd800289242ff34adc50 254 Gene3D G3DSA:3.40.50.300 4 251 1.2E-82 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10070 5ff1d03722d1fd800289242ff34adc50 254 PIRSF PIRSF039085 2 254 4.4E-125 T 09-03-2017 IPR030679 ABC-type amino acid transport system, ATPase component, HisP-type GO:0003333|GO:0015424 TK78_RS05990 41761c4e0b36f9768311a600f346d3ad 637 SUPERFAMILY SSF52518 294 477 1.71E-49 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS05990 41761c4e0b36f9768311a600f346d3ad 637 SUPERFAMILY SSF52922 488 619 3.66E-27 T 09-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 TK78_RS05990 41761c4e0b36f9768311a600f346d3ad 637 SMART SM00861 315 479 1.3E-48 T 09-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain TK78_RS05990 41761c4e0b36f9768311a600f346d3ad 637 Gene3D G3DSA:3.40.50.970 330 479 7.8E-29 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS05990 41761c4e0b36f9768311a600f346d3ad 637 Pfam PF02780 Transketolase, C-terminal domain 499 612 9.1E-29 T 09-03-2017 IPR033248 Transketolase, C-terminal domain TK78_RS05990 41761c4e0b36f9768311a600f346d3ad 637 Hamap MF_00315 1-deoxy-D-xylulose-5-phosphate synthase [dxs]. 3 621 41.324 T 09-03-2017 IPR005477 Deoxyxylulose-5-phosphate synthase GO:0008661|GO:0016114 KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 TK78_RS05990 41761c4e0b36f9768311a600f346d3ad 637 ProSitePatterns PS00802 Transketolase signature 2. 421 437 - T 09-03-2017 IPR020826 Transketolase binding site KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 TK78_RS05990 41761c4e0b36f9768311a600f346d3ad 637 Pfam PF02779 Transketolase, pyrimidine binding domain 314 477 4.9E-35 T 09-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain TK78_RS05990 41761c4e0b36f9768311a600f346d3ad 637 Pfam PF13292 1-deoxy-D-xylulose-5-phosphate synthase 4 279 2.3E-107 T 09-03-2017 IPR005477 Deoxyxylulose-5-phosphate synthase GO:0008661|GO:0016114 KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 TK78_RS05990 41761c4e0b36f9768311a600f346d3ad 637 Gene3D G3DSA:3.40.50.920 489 619 7.2E-31 T 09-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 TK78_RS05990 41761c4e0b36f9768311a600f346d3ad 637 Gene3D G3DSA:3.40.50.970 239 329 4.4E-61 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS05990 41761c4e0b36f9768311a600f346d3ad 637 Gene3D G3DSA:3.40.50.970 20 194 4.4E-61 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS05990 41761c4e0b36f9768311a600f346d3ad 637 ProSitePatterns PS00801 Transketolase signature 1. 29 48 - T 09-03-2017 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 TK78_RS05990 41761c4e0b36f9768311a600f346d3ad 637 TIGRFAM TIGR00204 dxs: 1-deoxy-D-xylulose-5-phosphate synthase 5 617 2.5E-186 T 09-03-2017 IPR005477 Deoxyxylulose-5-phosphate synthase GO:0008661|GO:0016114 KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 TK78_RS05990 41761c4e0b36f9768311a600f346d3ad 637 SUPERFAMILY SSF52518 2 345 4.72E-73 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS24325 e2d02fe628f2ea75ab95f6bf573ca312 356 Gene3D G3DSA:3.20.20.190 40 351 2.0E-81 T 09-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 TK78_RS24325 e2d02fe628f2ea75ab95f6bf573ca312 356 SUPERFAMILY SSF51695 40 351 2.88E-70 T 09-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 TK78_RS24325 e2d02fe628f2ea75ab95f6bf573ca312 356 Pfam PF03009 Glycerophosphoryl diester phosphodiesterase family 46 345 8.2E-38 T 09-03-2017 IPR030395 Glycerophosphodiester phosphodiesterase domain GO:0006629|GO:0008081 TK78_RS17645 ea71443e0af7c7ccabc8b5eda1f77a59 482 Gene3D G3DSA:2.40.50.100 3 97 2.9E-25 T 09-03-2017 TK78_RS17645 ea71443e0af7c7ccabc8b5eda1f77a59 482 Pfam PF00364 Biotin-requiring enzyme 6 77 1.3E-16 T 09-03-2017 IPR000089 Biotin/lipoyl attachment TK78_RS17645 ea71443e0af7c7ccabc8b5eda1f77a59 482 Pfam PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain) 251 479 2.2E-73 T 09-03-2017 IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 TK78_RS17645 ea71443e0af7c7ccabc8b5eda1f77a59 482 SUPERFAMILY SSF52777 238 479 2.31E-72 T 09-03-2017 TK78_RS17645 ea71443e0af7c7ccabc8b5eda1f77a59 482 SUPERFAMILY SSF51230 3 97 4.97E-25 T 09-03-2017 IPR011053 Single hybrid motif TK78_RS17645 ea71443e0af7c7ccabc8b5eda1f77a59 482 Gene3D G3DSA:4.10.320.10 175 222 3.5E-15 T 09-03-2017 IPR004167 E3-binding domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 TK78_RS17645 ea71443e0af7c7ccabc8b5eda1f77a59 482 Gene3D G3DSA:3.30.559.10 242 479 8.9E-77 T 09-03-2017 IPR023213 Chloramphenicol acetyltransferase-like domain Reactome: R-HSA-389661 TK78_RS17645 ea71443e0af7c7ccabc8b5eda1f77a59 482 SUPERFAMILY SSF47005 172 215 1.96E-10 T 09-03-2017 IPR004167 E3-binding domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 TK78_RS17645 ea71443e0af7c7ccabc8b5eda1f77a59 482 Pfam PF02817 e3 binding domain 178 211 8.5E-13 T 09-03-2017 IPR004167 E3-binding domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 TK78_RS16700 7c3456322294615031a3c1ff49d81167 141 SUPERFAMILY SSF88723 7 123 5.33E-12 T 09-03-2017 IPR029060 PIN domain-like TK78_RS16700 7c3456322294615031a3c1ff49d81167 141 Gene3D G3DSA:3.40.50.1010 60 127 3.5E-6 T 09-03-2017 IPR029060 PIN domain-like TK78_RS16700 7c3456322294615031a3c1ff49d81167 141 Hamap MF_00265 tRNA(fMet)-specific endonuclease VapC [vapC]. 7 130 12.035 T 09-03-2017 IPR022907 VapC family GO:0004540 TK78_RS16700 7c3456322294615031a3c1ff49d81167 141 Pfam PF01850 PIN domain 8 125 2.0E-11 T 09-03-2017 IPR002716 PIN domain TK78_RS20760 ad40a7bcd19bc354cff4482af85958b3 378 Gene3D G3DSA:1.20.1250.20 203 371 1.0E-11 T 09-03-2017 TK78_RS20760 ad40a7bcd19bc354cff4482af85958b3 378 Gene3D G3DSA:1.20.1250.20 25 175 4.1E-11 T 09-03-2017 TK78_RS20760 ad40a7bcd19bc354cff4482af85958b3 378 SUPERFAMILY SSF103473 3 373 5.89E-37 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS20760 ad40a7bcd19bc354cff4482af85958b3 378 Pfam PF07690 Major Facilitator Superfamily 3 294 8.0E-18 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS07400 0e0ddbfed3d7d7cbc523d0220c7b5f16 720 SUPERFAMILY SSF55021 638 713 2.38E-5 T 09-03-2017 TK78_RS07400 0e0ddbfed3d7d7cbc523d0220c7b5f16 720 Pfam PF13328 HD domain 65 212 4.3E-40 T 09-03-2017 IPR003607 HD/PDEase domain TK78_RS07400 0e0ddbfed3d7d7cbc523d0220c7b5f16 720 Pfam PF04607 Region found in RelA / SpoT proteins 299 366 4.6E-14 T 09-03-2017 IPR007685 RelA/SpoT GO:0015969 TK78_RS07400 0e0ddbfed3d7d7cbc523d0220c7b5f16 720 SUPERFAMILY SSF81271 431 487 8.72E-8 T 09-03-2017 IPR012676 TGS-like KEGG: 00970+6.1.1.3 TK78_RS07400 0e0ddbfed3d7d7cbc523d0220c7b5f16 720 Gene3D G3DSA:3.10.20.30 430 487 7.4E-9 T 09-03-2017 IPR012675 Beta-grasp domain TK78_RS07400 0e0ddbfed3d7d7cbc523d0220c7b5f16 720 SUPERFAMILY SSF81301 235 372 4.09E-32 T 09-03-2017 TK78_RS07400 0e0ddbfed3d7d7cbc523d0220c7b5f16 720 Pfam PF02824 TGS domain 431 487 1.3E-11 T 09-03-2017 IPR004095 TGS KEGG: 00970+6.1.1.3 TK78_RS07400 0e0ddbfed3d7d7cbc523d0220c7b5f16 720 Pfam PF13291 ACT domain 639 712 7.2E-10 T 09-03-2017 IPR002912 ACT domain GO:0008152|GO:0016597 TK78_RS07400 0e0ddbfed3d7d7cbc523d0220c7b5f16 720 SMART SM00471 80 190 2.3E-11 T 09-03-2017 IPR003607 HD/PDEase domain TK78_RS07400 0e0ddbfed3d7d7cbc523d0220c7b5f16 720 Gene3D G3DSA:3.30.460.10 229 359 1.1E-23 T 09-03-2017 TK78_RS07400 0e0ddbfed3d7d7cbc523d0220c7b5f16 720 SUPERFAMILY SSF109604 47 228 1.73E-62 T 09-03-2017 TK78_RS07400 0e0ddbfed3d7d7cbc523d0220c7b5f16 720 SMART SM00954 271 379 2.1E-26 T 09-03-2017 IPR007685 RelA/SpoT GO:0015969 TK78_RS01675 73cbe5293ae03b016a11bf406440df0c 821 Pfam PF08448 PAS fold 145 254 1.8E-19 T 09-03-2017 IPR013656 PAS fold-4 TK78_RS01675 73cbe5293ae03b016a11bf406440df0c 821 Gene3D G3DSA:3.30.450.40 265 448 6.3E-34 T 09-03-2017 IPR029016 GAF domain-like TK78_RS01675 73cbe5293ae03b016a11bf406440df0c 821 SUPERFAMILY SSF55781 352 444 1.15E-10 T 09-03-2017 IPR029016 GAF domain-like TK78_RS01675 73cbe5293ae03b016a11bf406440df0c 821 SUPERFAMILY SSF55874 737 815 2.21E-5 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS01675 73cbe5293ae03b016a11bf406440df0c 821 SUPERFAMILY SSF55785 139 252 5.76E-12 T 09-03-2017 IPR000014 PAS domain TK78_RS01675 73cbe5293ae03b016a11bf406440df0c 821 SUPERFAMILY SSF55785 26 125 1.42E-11 T 09-03-2017 IPR000014 PAS domain TK78_RS01675 73cbe5293ae03b016a11bf406440df0c 821 Gene3D G3DSA:3.30.450.20 139 254 1.5E-16 T 09-03-2017 TK78_RS01675 73cbe5293ae03b016a11bf406440df0c 821 Pfam PF01590 GAF domain 347 440 1.7E-7 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS01675 73cbe5293ae03b016a11bf406440df0c 821 Pfam PF13581 Histidine kinase-like ATPase domain 708 815 2.6E-8 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS01675 73cbe5293ae03b016a11bf406440df0c 821 SMART SM00091 18 84 3.8 T 09-03-2017 IPR000014 PAS domain TK78_RS01675 73cbe5293ae03b016a11bf406440df0c 821 SMART SM00091 137 203 1.3 T 09-03-2017 IPR000014 PAS domain TK78_RS01675 73cbe5293ae03b016a11bf406440df0c 821 SUPERFAMILY SSF81606 485 693 8.37E-7 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS01675 73cbe5293ae03b016a11bf406440df0c 821 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 498 694 1.8E-51 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS01675 73cbe5293ae03b016a11bf406440df0c 821 Pfam PF00989 PAS fold 27 123 7.5E-8 T 09-03-2017 IPR013767 PAS fold GO:0006355 TK78_RS01675 73cbe5293ae03b016a11bf406440df0c 821 SMART SM00065 259 450 0.0021 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS01675 73cbe5293ae03b016a11bf406440df0c 821 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 27 130 1.5E-7 T 09-03-2017 IPR000014 PAS domain TK78_RS01675 73cbe5293ae03b016a11bf406440df0c 821 Gene3D G3DSA:3.30.450.20 26 126 4.1E-12 T 09-03-2017 TK78_RS01675 73cbe5293ae03b016a11bf406440df0c 821 SMART SM00331 471 694 5.0E-35 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS03015 88980aa298788992c79e32dd1b32a554 481 SMART SM00846 129 289 8.5E-52 T 09-03-2017 IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS03015 88980aa298788992c79e32dd1b32a554 481 Pfam PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 130 289 3.0E-39 T 09-03-2017 IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS03015 88980aa298788992c79e32dd1b32a554 481 SUPERFAMILY SSF55347 289 452 3.27E-49 T 09-03-2017 TK78_RS03015 88980aa298788992c79e32dd1b32a554 481 Pfam PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 294 451 4.5E-44 T 09-03-2017 IPR020829 Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS03015 88980aa298788992c79e32dd1b32a554 481 Gene3D G3DSA:3.30.360.10 298 453 2.7E-50 T 09-03-2017 TK78_RS03015 88980aa298788992c79e32dd1b32a554 481 SUPERFAMILY SSF51735 130 305 4.14E-44 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS03015 88980aa298788992c79e32dd1b32a554 481 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 283 301 1.1E-18 T 09-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS03015 88980aa298788992c79e32dd1b32a554 481 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 310 326 1.1E-18 T 09-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS03015 88980aa298788992c79e32dd1b32a554 481 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 366 383 1.1E-18 T 09-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS03015 88980aa298788992c79e32dd1b32a554 481 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 247 260 1.1E-18 T 09-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS03015 88980aa298788992c79e32dd1b32a554 481 ProSitePatterns PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 287 294 - T 09-03-2017 IPR020830 Glyceraldehyde 3-phosphate dehydrogenase, active site GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS03015 88980aa298788992c79e32dd1b32a554 481 Gene3D G3DSA:3.40.50.720 130 297 1.2E-48 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS19350 a6cc732e976e2ce53bc509464eeaa40b 304 SUPERFAMILY SSF56112 32 286 1.6E-25 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS19350 a6cc732e976e2ce53bc509464eeaa40b 304 Pfam PF04655 Aminoglycoside/hydroxyurea antibiotic resistance kinase 37 286 2.0E-46 T 09-03-2017 IPR006748 Aminoglycoside/hydroxyurea antibiotic resistance kinase GO:0006468|GO:0016773|GO:0019748 TK78_RS19350 a6cc732e976e2ce53bc509464eeaa40b 304 Gene3D G3DSA:3.90.1200.10 120 212 5.7E-4 T 09-03-2017 TK78_RS02840 032fbfd322785ad1a51ec3b2b9d411a4 512 Gene3D G3DSA:1.10.1060.10 327 416 2.7E-11 T 09-03-2017 TK78_RS02840 032fbfd322785ad1a51ec3b2b9d411a4 512 Gene3D G3DSA:3.40.50.10420 82 145 6.4E-43 T 09-03-2017 IPR024185 5-formyltetrahydrofolate cyclo-ligase-like domain TK78_RS02840 032fbfd322785ad1a51ec3b2b9d411a4 512 Gene3D G3DSA:3.40.50.10420 209 312 6.4E-43 T 09-03-2017 IPR024185 5-formyltetrahydrofolate cyclo-ligase-like domain TK78_RS02840 032fbfd322785ad1a51ec3b2b9d411a4 512 Pfam PF13183 4Fe-4S dicluster domain 328 399 1.2E-7 T 09-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TK78_RS02840 032fbfd322785ad1a51ec3b2b9d411a4 512 Pfam PF02589 Uncharacterised ACR, YkgG family COG1556 87 310 5.9E-44 T 09-03-2017 IPR003741 LUD domain TK78_RS02840 032fbfd322785ad1a51ec3b2b9d411a4 512 Pfam PF11870 Domain of unknown function (DUF3390) 420 489 2.8E-8 T 09-03-2017 IPR024569 4Fe-4S binding protein, C-terminal TK78_RS02840 032fbfd322785ad1a51ec3b2b9d411a4 512 SUPERFAMILY SSF100950 152 312 2.26E-35 T 09-03-2017 TK78_RS02840 032fbfd322785ad1a51ec3b2b9d411a4 512 SUPERFAMILY SSF100950 82 106 2.26E-35 T 09-03-2017 TK78_RS02840 032fbfd322785ad1a51ec3b2b9d411a4 512 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 330 341 - T 09-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TK78_RS02840 032fbfd322785ad1a51ec3b2b9d411a4 512 SUPERFAMILY SSF54862 308 417 7.95E-14 T 09-03-2017 TK78_RS31695 3c0dbc41119365f1524c7427f6094aa4 174 Pfam PF13673 Acetyltransferase (GNAT) domain 55 149 1.3E-10 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS31695 3c0dbc41119365f1524c7427f6094aa4 174 SUPERFAMILY SSF55729 11 171 1.21E-27 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS31695 3c0dbc41119365f1524c7427f6094aa4 174 Gene3D G3DSA:3.40.630.30 16 171 3.4E-34 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS26165 cddde78ec4a28429909653d471defa94 221 SUPERFAMILY SSF48613 8 216 9.6E-62 T 09-03-2017 IPR016084 Haem oxygenase-like, multi-helical Reactome: R-HSA-189483|Reactome: R-HSA-917937 TK78_RS26165 cddde78ec4a28429909653d471defa94 221 Pfam PF01126 Heme oxygenase 9 212 9.2E-67 T 09-03-2017 IPR016053 Haem oxygenase-like GO:0004392|GO:0006788|GO:0055114 KEGG: 00860+1.14.14.18|Reactome: R-HSA-189483|Reactome: R-HSA-917937 TK78_RS26165 cddde78ec4a28429909653d471defa94 221 Gene3D G3DSA:1.20.910.10 6 216 1.8E-66 T 09-03-2017 IPR016084 Haem oxygenase-like, multi-helical Reactome: R-HSA-189483|Reactome: R-HSA-917937 TK78_RS26165 cddde78ec4a28429909653d471defa94 221 PRINTS PR00088 Haem oxygenase signature 44 69 8.0E-33 T 09-03-2017 IPR002051 Haem oxygenase GO:0004392|GO:0006788|GO:0055114 KEGG: 00860+1.14.14.18|Reactome: R-HSA-189483|Reactome: R-HSA-917937 TK78_RS26165 cddde78ec4a28429909653d471defa94 221 PRINTS PR00088 Haem oxygenase signature 122 143 8.0E-33 T 09-03-2017 IPR002051 Haem oxygenase GO:0004392|GO:0006788|GO:0055114 KEGG: 00860+1.14.14.18|Reactome: R-HSA-189483|Reactome: R-HSA-917937 TK78_RS26165 cddde78ec4a28429909653d471defa94 221 PRINTS PR00088 Haem oxygenase signature 198 216 8.0E-33 T 09-03-2017 IPR002051 Haem oxygenase GO:0004392|GO:0006788|GO:0055114 KEGG: 00860+1.14.14.18|Reactome: R-HSA-189483|Reactome: R-HSA-917937 TK78_RS26165 cddde78ec4a28429909653d471defa94 221 PRINTS PR00088 Haem oxygenase signature 166 187 8.0E-33 T 09-03-2017 IPR002051 Haem oxygenase GO:0004392|GO:0006788|GO:0055114 KEGG: 00860+1.14.14.18|Reactome: R-HSA-189483|Reactome: R-HSA-917937 TK78_RS26165 cddde78ec4a28429909653d471defa94 221 PRINTS PR00088 Haem oxygenase signature 9 34 8.0E-33 T 09-03-2017 IPR002051 Haem oxygenase GO:0004392|GO:0006788|GO:0055114 KEGG: 00860+1.14.14.18|Reactome: R-HSA-189483|Reactome: R-HSA-917937 TK78_RS26165 cddde78ec4a28429909653d471defa94 221 PRINTS PR00088 Haem oxygenase signature 69 94 8.0E-33 T 09-03-2017 IPR002051 Haem oxygenase GO:0004392|GO:0006788|GO:0055114 KEGG: 00860+1.14.14.18|Reactome: R-HSA-189483|Reactome: R-HSA-917937 TK78_RS26165 cddde78ec4a28429909653d471defa94 221 PIRSF PIRSF000343 2 221 6.6E-69 T 09-03-2017 IPR002051 Haem oxygenase GO:0004392|GO:0006788|GO:0055114 KEGG: 00860+1.14.14.18|Reactome: R-HSA-189483|Reactome: R-HSA-917937 TK78_RS27585 02d7c2b1aacd28bdecbe4544ad091434 479 TIGRFAM TIGR01064 pyruv_kin: pyruvate kinase 2 472 1.8E-167 T 09-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS27585 02d7c2b1aacd28bdecbe4544ad091434 479 SUPERFAMILY SSF51621 1 74 4.19E-97 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS27585 02d7c2b1aacd28bdecbe4544ad091434 479 SUPERFAMILY SSF51621 156 339 4.19E-97 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS27585 02d7c2b1aacd28bdecbe4544ad091434 479 Gene3D G3DSA:2.40.33.10 73 168 1.4E-28 T 09-03-2017 IPR015806 Pyruvate kinase, beta-barrel insert domain GO:0004743|GO:0006096 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS27585 02d7c2b1aacd28bdecbe4544ad091434 479 SUPERFAMILY SSF52935 322 472 1.7E-38 T 09-03-2017 IPR015795 Pyruvate kinase, C-terminal KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS27585 02d7c2b1aacd28bdecbe4544ad091434 479 Pfam PF00224 Pyruvate kinase, barrel domain 1 338 1.8E-126 T 09-03-2017 IPR015793 Pyruvate kinase, barrel GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS27585 02d7c2b1aacd28bdecbe4544ad091434 479 Pfam PF02887 Pyruvate kinase, alpha/beta domain 358 470 1.5E-27 T 09-03-2017 IPR015795 Pyruvate kinase, C-terminal KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS27585 02d7c2b1aacd28bdecbe4544ad091434 479 Gene3D G3DSA:3.40.1380.20 326 472 6.7E-44 T 09-03-2017 IPR015794 Pyruvate kinase, alpha/beta GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS27585 02d7c2b1aacd28bdecbe4544ad091434 479 ProSitePatterns PS00110 Pyruvate kinase active site signature. 214 226 - T 09-03-2017 IPR018209 Pyruvate kinase, active site GO:0004743|GO:0006096 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS27585 02d7c2b1aacd28bdecbe4544ad091434 479 PRINTS PR01050 Pyruvate kinase family signature 59 75 2.3E-66 T 09-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS27585 02d7c2b1aacd28bdecbe4544ad091434 479 PRINTS PR01050 Pyruvate kinase family signature 243 267 2.3E-66 T 09-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS27585 02d7c2b1aacd28bdecbe4544ad091434 479 PRINTS PR01050 Pyruvate kinase family signature 186 200 2.3E-66 T 09-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS27585 02d7c2b1aacd28bdecbe4544ad091434 479 PRINTS PR01050 Pyruvate kinase family signature 312 328 2.3E-66 T 09-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS27585 02d7c2b1aacd28bdecbe4544ad091434 479 PRINTS PR01050 Pyruvate kinase family signature 293 311 2.3E-66 T 09-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS27585 02d7c2b1aacd28bdecbe4544ad091434 479 PRINTS PR01050 Pyruvate kinase family signature 216 242 2.3E-66 T 09-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS27585 02d7c2b1aacd28bdecbe4544ad091434 479 PRINTS PR01050 Pyruvate kinase family signature 268 292 2.3E-66 T 09-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS27585 02d7c2b1aacd28bdecbe4544ad091434 479 SUPERFAMILY SSF50800 70 166 3.49E-26 T 09-03-2017 IPR011037 Pyruvate kinase-like, insert domain TK78_RS27585 02d7c2b1aacd28bdecbe4544ad091434 479 Gene3D G3DSA:3.20.20.60 169 325 3.1E-103 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS27585 02d7c2b1aacd28bdecbe4544ad091434 479 Gene3D G3DSA:3.20.20.60 2 72 3.1E-103 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 SUPERFAMILY SSF51126 344 485 4.19E-15 T 09-03-2017 IPR011050 Pectin lyase fold/virulence factor TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 SMART SM00710 151 173 650.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 SMART SM00710 174 196 20.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 SMART SM00710 128 150 27.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 SMART SM00710 362 383 4800.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 SMART SM00710 339 361 8700.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 SMART SM00710 385 406 280.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 SMART SM00710 430 452 330.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 SMART SM00710 244 266 7500.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 SMART SM00710 407 429 12.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 SMART SM00710 267 289 1900.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 SMART SM00710 221 243 710.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 SMART SM00710 198 220 8500.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 Pfam PF13229 Right handed beta helix region 121 242 7.4E-17 T 09-03-2017 TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 Pfam PF13229 Right handed beta helix region 356 477 8.9E-13 T 09-03-2017 TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 SUPERFAMILY SSF52540 548 757 1.04E-30 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 590 720 1.2E-15 T 09-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 SUPERFAMILY SSF51126 206 360 4.08E-9 T 09-03-2017 IPR011050 Pectin lyase fold/virulence factor TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 Gene3D G3DSA:3.40.50.300 549 738 1.1E-23 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 SMART SM00722 41 172 7.3 T 09-03-2017 IPR006633 Carbohydrate-binding/sugar hydrolysis domain TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 SMART SM00722 313 451 2.7E-6 T 09-03-2017 IPR006633 Carbohydrate-binding/sugar hydrolysis domain TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 Gene3D G3DSA:2.160.20.10 387 470 9.4E-8 T 09-03-2017 IPR012334 Pectin lyase fold TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 Gene3D G3DSA:2.160.20.10 297 386 8.6E-5 T 09-03-2017 IPR012334 Pectin lyase fold TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 Gene3D G3DSA:2.160.20.10 3 255 2.4E-23 T 09-03-2017 IPR012334 Pectin lyase fold TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 SUPERFAMILY SSF51126 20 241 2.4E-31 T 09-03-2017 IPR011050 Pectin lyase fold/virulence factor TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 PRINTS PR00819 CbxX/CfqX superfamily signature 548 562 1.7E-47 T 09-03-2017 IPR000641 CbxX/CfqX GO:0005524 TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 PRINTS PR00819 CbxX/CfqX superfamily signature 671 683 1.7E-47 T 09-03-2017 IPR000641 CbxX/CfqX GO:0005524 TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 PRINTS PR00819 CbxX/CfqX superfamily signature 692 709 1.7E-47 T 09-03-2017 IPR000641 CbxX/CfqX GO:0005524 TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 PRINTS PR00819 CbxX/CfqX superfamily signature 640 659 1.7E-47 T 09-03-2017 IPR000641 CbxX/CfqX GO:0005524 TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 PRINTS PR00819 CbxX/CfqX superfamily signature 588 603 1.7E-47 T 09-03-2017 IPR000641 CbxX/CfqX GO:0005524 TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 PRINTS PR00819 CbxX/CfqX superfamily signature 709 728 1.7E-47 T 09-03-2017 IPR000641 CbxX/CfqX GO:0005524 TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 PRINTS PR00819 CbxX/CfqX superfamily signature 766 778 1.7E-47 T 09-03-2017 IPR000641 CbxX/CfqX GO:0005524 TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 PRINTS PR00819 CbxX/CfqX superfamily signature 626 640 1.7E-47 T 09-03-2017 IPR000641 CbxX/CfqX GO:0005524 TK78_RS32875 43d5fde3e2b08b76b2039798c27c4f54 809 SMART SM00382 585 704 1.2E-5 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS07440 f452490b39800e320cbc7d492d95359e 464 SUPERFAMILY SSF55874 297 459 1.57E-33 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS07440 f452490b39800e320cbc7d492d95359e 464 SMART SM00387 351 461 9.2E-26 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS07440 f452490b39800e320cbc7d492d95359e 464 SUPERFAMILY SSF158472 192 242 2.09E-6 T 09-03-2017 TK78_RS07440 f452490b39800e320cbc7d492d95359e 464 PRINTS PR00344 Bacterial sensor protein C-terminal signature 445 458 1.6E-7 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS07440 f452490b39800e320cbc7d492d95359e 464 PRINTS PR00344 Bacterial sensor protein C-terminal signature 421 439 1.6E-7 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS07440 f452490b39800e320cbc7d492d95359e 464 PRINTS PR00344 Bacterial sensor protein C-terminal signature 388 402 1.6E-7 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS07440 f452490b39800e320cbc7d492d95359e 464 SUPERFAMILY SSF47384 228 306 5.89E-14 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS07440 f452490b39800e320cbc7d492d95359e 464 SMART SM00304 191 244 1.5E-9 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS07440 f452490b39800e320cbc7d492d95359e 464 Pfam PF00512 His Kinase A (phospho-acceptor) domain 246 307 1.2E-11 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS07440 f452490b39800e320cbc7d492d95359e 464 Gene3D G3DSA:3.30.565.10 310 461 2.7E-32 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS07440 f452490b39800e320cbc7d492d95359e 464 SMART SM00388 245 308 1.6E-13 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS07440 f452490b39800e320cbc7d492d95359e 464 Pfam PF00672 HAMP domain 174 240 5.5E-12 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS07440 f452490b39800e320cbc7d492d95359e 464 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 352 460 4.5E-17 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS07440 f452490b39800e320cbc7d492d95359e 464 Gene3D G3DSA:1.10.287.130 235 303 8.6E-13 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS09120 0ca9ce8773ea8bada39ce7793b4201c5 707 SMART SM00382 481 609 6.6E-10 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS09120 0ca9ce8773ea8bada39ce7793b4201c5 707 SUPERFAMILY SSF52540 438 675 8.55E-36 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09120 0ca9ce8773ea8bada39ce7793b4201c5 707 Gene3D G3DSA:3.40.50.300 441 625 9.2E-33 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09120 0ca9ce8773ea8bada39ce7793b4201c5 707 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 486 610 4.3E-24 T 09-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 TK78_RS22275 ba19eff79268b571e0cc5fcd87d725c5 162 ProDom PD004488 SSRA-BINDING RNA-BINDING SMPB SMALL B TMRNA-BINDING SSRA 3D-STRUCTURE HOMOLOG BINDING 12 135 2.0E-61 T 09-03-2017 IPR000037 SsrA-binding protein GO:0003723 TK78_RS22275 ba19eff79268b571e0cc5fcd87d725c5 162 Hamap MF_00023 SsrA-binding protein [smpB]. 1 161 70.767 T 09-03-2017 IPR000037 SsrA-binding protein GO:0003723 TK78_RS22275 ba19eff79268b571e0cc5fcd87d725c5 162 Gene3D G3DSA:2.40.280.10 10 130 6.3E-53 T 09-03-2017 IPR023620 Small protein B TK78_RS22275 ba19eff79268b571e0cc5fcd87d725c5 162 TIGRFAM TIGR00086 smpB: SsrA-binding protein 12 152 5.8E-58 T 09-03-2017 IPR000037 SsrA-binding protein GO:0003723 TK78_RS22275 ba19eff79268b571e0cc5fcd87d725c5 162 ProSitePatterns PS01317 SsrA-binding protein. 30 42 - T 09-03-2017 IPR020081 SsrA-binding protein, conserved site TK78_RS22275 ba19eff79268b571e0cc5fcd87d725c5 162 SUPERFAMILY SSF74982 5 135 2.35E-53 T 09-03-2017 IPR023620 Small protein B TK78_RS22275 ba19eff79268b571e0cc5fcd87d725c5 162 Pfam PF01668 SmpB protein 11 74 1.6E-29 T 09-03-2017 IPR000037 SsrA-binding protein GO:0003723 TK78_RS19480 1fac9eaf538bdd0ef6e34ac0bc3e0bc2 455 Gene3D G3DSA:2.40.10.10 206 289 1.4E-29 T 09-03-2017 TK78_RS19480 1fac9eaf538bdd0ef6e34ac0bc3e0bc2 455 SUPERFAMILY SSF51055 412 454 5.89E-15 T 09-03-2017 IPR003610 Carbohydrate-binding module family 5/12 GO:0004553|GO:0005576|GO:0005975|GO:0030246 TK78_RS19480 1fac9eaf538bdd0ef6e34ac0bc3e0bc2 455 PIRSF PIRSF001134 2 394 2.8E-150 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS19480 1fac9eaf538bdd0ef6e34ac0bc3e0bc2 455 Pfam PF02983 Alpha-lytic protease prodomain 130 186 6.9E-17 T 09-03-2017 IPR004236 Peptidase S1A, alpha-lytic prodomain GO:0005576|GO:0006508|GO:0008236 TK78_RS19480 1fac9eaf538bdd0ef6e34ac0bc3e0bc2 455 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 313 330 1.5E-44 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS19480 1fac9eaf538bdd0ef6e34ac0bc3e0bc2 455 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 292 312 1.5E-44 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS19480 1fac9eaf538bdd0ef6e34ac0bc3e0bc2 455 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 332 355 1.5E-44 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS19480 1fac9eaf538bdd0ef6e34ac0bc3e0bc2 455 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 232 246 1.5E-44 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS19480 1fac9eaf538bdd0ef6e34ac0bc3e0bc2 455 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 356 370 1.5E-44 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS19480 1fac9eaf538bdd0ef6e34ac0bc3e0bc2 455 Pfam PF02839 Carbohydrate binding domain 411 452 9.3E-8 T 09-03-2017 IPR003610 Carbohydrate-binding module family 5/12 GO:0004553|GO:0005576|GO:0005975|GO:0030246 TK78_RS19480 1fac9eaf538bdd0ef6e34ac0bc3e0bc2 455 ProSitePatterns PS00135 Serine proteases, trypsin family, serine active site. 341 352 - T 09-03-2017 IPR033116 Serine proteases, trypsin family, serine active site TK78_RS19480 1fac9eaf538bdd0ef6e34ac0bc3e0bc2 455 SMART SM00495 409 455 3.1E-10 T 09-03-2017 IPR003610 Carbohydrate-binding module family 5/12 GO:0004553|GO:0005576|GO:0005975|GO:0030246 TK78_RS19480 1fac9eaf538bdd0ef6e34ac0bc3e0bc2 455 Gene3D G3DSA:2.10.10.20 411 455 7.1E-23 T 09-03-2017 IPR003610 Carbohydrate-binding module family 5/12 GO:0004553|GO:0005576|GO:0005975|GO:0030246 TK78_RS19480 1fac9eaf538bdd0ef6e34ac0bc3e0bc2 455 SUPERFAMILY SSF50494 207 387 8.56E-35 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS19480 1fac9eaf538bdd0ef6e34ac0bc3e0bc2 455 Gene3D G3DSA:2.40.10.10 290 378 5.2E-31 T 09-03-2017 TK78_RS19480 1fac9eaf538bdd0ef6e34ac0bc3e0bc2 455 Gene3D G3DSA:3.30.300.50 47 128 2.4E-25 T 09-03-2017 TK78_RS19480 1fac9eaf538bdd0ef6e34ac0bc3e0bc2 455 Gene3D G3DSA:3.30.300.50 130 198 3.4E-19 T 09-03-2017 TK78_RS16830 d6e99e16c82a800e238ffb0331ca7c7f 325 Gene3D G3DSA:3.40.1350.10 200 312 1.6E-6 T 09-03-2017 IPR011856 tRNA endonuclease-like domain GO:0003676|GO:0004518 Reactome: R-HSA-6784531 TK78_RS16830 d6e99e16c82a800e238ffb0331ca7c7f 325 Pfam PF04471 Restriction endonuclease 185 312 8.8E-10 T 09-03-2017 IPR007560 Restriction endonuclease type IV, Mrr GO:0003677|GO:0004519|GO:0009307 TK78_RS33875 ce94dbf7981404d46c80e8c3e2a6a936 397 Pfam PF01546 Peptidase family M20/M25/M40 111 363 3.2E-7 T 09-03-2017 IPR002933 Peptidase M20 GO:0008152|GO:0016787 TK78_RS33875 ce94dbf7981404d46c80e8c3e2a6a936 397 SUPERFAMILY SSF53187 32 204 3.64E-57 T 09-03-2017 TK78_RS33875 ce94dbf7981404d46c80e8c3e2a6a936 397 SUPERFAMILY SSF53187 304 392 3.64E-57 T 09-03-2017 TK78_RS33875 ce94dbf7981404d46c80e8c3e2a6a936 397 Gene3D G3DSA:3.40.630.10 301 393 7.9E-63 T 09-03-2017 TK78_RS33875 ce94dbf7981404d46c80e8c3e2a6a936 397 Gene3D G3DSA:3.40.630.10 27 192 7.9E-63 T 09-03-2017 TK78_RS33875 ce94dbf7981404d46c80e8c3e2a6a936 397 Gene3D G3DSA:3.30.70.360 193 295 5.1E-26 T 09-03-2017 IPR011650 Peptidase M20, dimerisation domain TK78_RS33875 ce94dbf7981404d46c80e8c3e2a6a936 397 SUPERFAMILY SSF55031 192 296 7.46E-22 T 09-03-2017 IPR011650 Peptidase M20, dimerisation domain TK78_RS33875 ce94dbf7981404d46c80e8c3e2a6a936 397 TIGRFAM TIGR01891 amidohydrolases: amidohydrolase 44 357 3.9E-61 T 09-03-2017 IPR017439 Amidohydrolase GO:0016787 TK78_RS33875 ce94dbf7981404d46c80e8c3e2a6a936 397 Pfam PF07687 Peptidase dimerisation domain 191 283 8.9E-12 T 09-03-2017 IPR011650 Peptidase M20, dimerisation domain TK78_RS33875 ce94dbf7981404d46c80e8c3e2a6a936 397 PIRSF PIRSF037226 22 397 4.8E-125 T 09-03-2017 IPR017144 Peptidase M20A, amidohydrolase, predicted TK78_RS13250 2387e26a4067689cac6860af75d1fafe 240 Gene3D G3DSA:3.40.50.790 68 158 1.7E-40 T 09-03-2017 IPR016095 Ribosomal protein L1, 3-layer alpha/beta-sandwich TK78_RS13250 2387e26a4067689cac6860af75d1fafe 240 SUPERFAMILY SSF56808 6 225 3.92E-82 T 09-03-2017 IPR023674 Ribosomal protein L1-like TK78_RS13250 2387e26a4067689cac6860af75d1fafe 240 ProSitePatterns PS01199 Ribosomal protein L1 signature. 120 138 - T 09-03-2017 IPR023673 Ribosomal protein L1, conserved site Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13250 2387e26a4067689cac6860af75d1fafe 240 Gene3D G3DSA:3.30.190.20 16 67 9.2E-45 T 09-03-2017 IPR016094 Ribosomal protein L1, 2-layer alpha/beta-sandwich GO:0003723 TK78_RS13250 2387e26a4067689cac6860af75d1fafe 240 Gene3D G3DSA:3.30.190.20 160 225 9.2E-45 T 09-03-2017 IPR016094 Ribosomal protein L1, 2-layer alpha/beta-sandwich GO:0003723 TK78_RS13250 2387e26a4067689cac6860af75d1fafe 240 PIRSF PIRSF002155 1 226 4.5E-72 T 09-03-2017 IPR002143 Ribosomal protein L1 GO:0003723|GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13250 2387e26a4067689cac6860af75d1fafe 240 TIGRFAM TIGR01169 rplA_bact: ribosomal protein uL1 2 226 1.8E-101 T 09-03-2017 IPR005878 Ribosomal protein L1, bacterial-type GO:0003723|GO:0003735|GO:0006412|GO:0015934 TK78_RS13250 2387e26a4067689cac6860af75d1fafe 240 Pfam PF00687 Ribosomal protein L1p/L10e family 31 219 1.9E-52 T 09-03-2017 IPR028364 Ribosomal protein L1/ribosomal biogenesis protein TK78_RS13250 2387e26a4067689cac6860af75d1fafe 240 Hamap MF_01318_B 50S ribosomal protein L1 [rplA]. 1 228 42.782 T 09-03-2017 IPR005878 Ribosomal protein L1, bacterial-type GO:0003723|GO:0003735|GO:0006412|GO:0015934 TK78_RS04050 0e5f24095649170524d2933bf1cf88bc 710 SUPERFAMILY SSF47781 415 589 1.91E-40 T 09-03-2017 IPR010994 RuvA domain 2-like TK78_RS04050 0e5f24095649170524d2933bf1cf88bc 710 Pfam PF01653 NAD-dependent DNA ligase adenylation domain 26 328 4.2E-68 T 09-03-2017 IPR013839 NAD-dependent DNA ligase, adenylation GO:0003911 TK78_RS04050 0e5f24095649170524d2933bf1cf88bc 710 Pfam PF12826 Helix-hairpin-helix motif 517 568 2.1E-10 T 09-03-2017 TK78_RS04050 0e5f24095649170524d2933bf1cf88bc 710 SUPERFAMILY SSF56091 17 328 3.68E-73 T 09-03-2017 TK78_RS04050 0e5f24095649170524d2933bf1cf88bc 710 Gene3D G3DSA:1.10.150.20 511 589 1.0E-15 T 09-03-2017 TK78_RS04050 0e5f24095649170524d2933bf1cf88bc 710 SMART SM00532 12 455 1.6E-135 T 09-03-2017 IPR013840 NAD-dependent DNA ligase, N-terminal GO:0003911 TK78_RS04050 0e5f24095649170524d2933bf1cf88bc 710 Gene3D G3DSA:3.30.470.30 125 226 5.0E-30 T 09-03-2017 TK78_RS04050 0e5f24095649170524d2933bf1cf88bc 710 Gene3D G3DSA:3.30.1490.70 227 323 2.9E-17 T 09-03-2017 TK78_RS04050 0e5f24095649170524d2933bf1cf88bc 710 Pfam PF03120 NAD-dependent DNA ligase OB-fold domain 333 409 3.5E-28 T 09-03-2017 IPR004150 NAD-dependent DNA ligase, OB-fold GO:0003911|GO:0006260|GO:0006281 TK78_RS04050 0e5f24095649170524d2933bf1cf88bc 710 SMART SM00292 622 703 1.3E-6 T 09-03-2017 IPR001357 BRCT domain TK78_RS04050 0e5f24095649170524d2933bf1cf88bc 710 TIGRFAM TIGR00575 dnlj: DNA ligase, NAD-dependent 29 694 1.3E-170 T 09-03-2017 IPR001679 NAD-dependent DNA ligase GO:0003911|GO:0006260|GO:0006281 TK78_RS04050 0e5f24095649170524d2933bf1cf88bc 710 Hamap MF_01588 DNA ligase [ligA]. 14 700 47.374 T 09-03-2017 IPR001679 NAD-dependent DNA ligase GO:0003911|GO:0006260|GO:0006281 TK78_RS04050 0e5f24095649170524d2933bf1cf88bc 710 Gene3D G3DSA:1.10.150.20 443 509 5.5E-22 T 09-03-2017 TK78_RS04050 0e5f24095649170524d2933bf1cf88bc 710 SMART SM00278 487 506 84.0 T 09-03-2017 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 TK78_RS04050 0e5f24095649170524d2933bf1cf88bc 710 SMART SM00278 551 570 4.2 T 09-03-2017 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 TK78_RS04050 0e5f24095649170524d2933bf1cf88bc 710 Gene3D G3DSA:2.40.50.140 330 401 9.3E-28 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS04050 0e5f24095649170524d2933bf1cf88bc 710 SUPERFAMILY SSF50249 330 411 9.42E-24 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS04050 0e5f24095649170524d2933bf1cf88bc 710 Pfam PF00533 BRCA1 C Terminus (BRCT) domain 621 699 1.7E-7 T 09-03-2017 IPR001357 BRCT domain TK78_RS04050 0e5f24095649170524d2933bf1cf88bc 710 ProSitePatterns PS01055 NAD-dependent DNA ligase signature 1. 121 150 - T 09-03-2017 IPR018239 NAD-dependent DNA ligase, active site TK78_RS04050 0e5f24095649170524d2933bf1cf88bc 710 Gene3D G3DSA:3.40.50.10190 623 701 9.8E-19 T 09-03-2017 IPR001357 BRCT domain TK78_RS04050 0e5f24095649170524d2933bf1cf88bc 710 PIRSF PIRSF001604 4 703 1.5E-192 T 09-03-2017 IPR001679 NAD-dependent DNA ligase GO:0003911|GO:0006260|GO:0006281 TK78_RS04050 0e5f24095649170524d2933bf1cf88bc 710 SUPERFAMILY SSF52113 621 701 2.62E-13 T 09-03-2017 IPR001357 BRCT domain TK78_RS04050 0e5f24095649170524d2933bf1cf88bc 710 Gene3D G3DSA:1.10.287.610 17 74 6.7E-9 T 09-03-2017 TK78_RS34410 16d59062d9da5b1cc8519dc1a50a21fb 229 SUPERFAMILY SSF48498 81 201 4.45E-22 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS34410 16d59062d9da5b1cc8519dc1a50a21fb 229 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 14 27 2.7E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS34410 16d59062d9da5b1cc8519dc1a50a21fb 229 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 35 58 2.7E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS34410 16d59062d9da5b1cc8519dc1a50a21fb 229 SUPERFAMILY SSF46689 2 83 1.74E-13 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS34410 16d59062d9da5b1cc8519dc1a50a21fb 229 Pfam PF00440 Bacterial regulatory proteins, tetR family 14 60 5.4E-10 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS34410 16d59062d9da5b1cc8519dc1a50a21fb 229 Gene3D G3DSA:1.10.357.10 1 190 5.1E-40 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS17715 fc9396db7a6c3ceac69e907517c64f57 219 Pfam PF00072 Response regulator receiver domain 9 121 2.5E-24 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS17715 fc9396db7a6c3ceac69e907517c64f57 219 SMART SM00448 7 120 5.2E-29 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS17715 fc9396db7a6c3ceac69e907517c64f57 219 ProSitePatterns PS00622 LuxR-type HTH domain signature. 171 198 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS17715 fc9396db7a6c3ceac69e907517c64f57 219 SUPERFAMILY SSF52172 6 136 1.71E-30 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS17715 fc9396db7a6c3ceac69e907517c64f57 219 Gene3D G3DSA:1.10.10.10 158 214 2.0E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS17715 fc9396db7a6c3ceac69e907517c64f57 219 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 187 199 4.5E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS17715 fc9396db7a6c3ceac69e907517c64f57 219 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 171 187 4.5E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS17715 fc9396db7a6c3ceac69e907517c64f57 219 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 157 171 4.5E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS17715 fc9396db7a6c3ceac69e907517c64f57 219 SMART SM00421 154 211 9.2E-20 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS17715 fc9396db7a6c3ceac69e907517c64f57 219 Pfam PF00196 Bacterial regulatory proteins, luxR family 156 210 6.0E-14 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS17715 fc9396db7a6c3ceac69e907517c64f57 219 SUPERFAMILY SSF46894 151 214 1.22E-16 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS17715 fc9396db7a6c3ceac69e907517c64f57 219 Gene3D G3DSA:3.40.50.2300 6 157 2.1E-38 T 09-03-2017 TK78_RS15200 e81735cb4f379215ee91e1f84b316049 653 Gene3D G3DSA:3.10.450.40 9 103 2.2E-30 T 09-03-2017 TK78_RS15200 e81735cb4f379215ee91e1f84b316049 653 Pfam PF02728 Copper amine oxidase, N3 domain 107 207 3.6E-18 T 09-03-2017 IPR015802 Copper amine oxidase, N3-terminal GO:0005507|GO:0008131|GO:0009308|GO:0048038|GO:0055114 KEGG: 00260+1.4.3.21|KEGG: 00350+1.4.3.21|KEGG: 00360+1.4.3.21|KEGG: 00410+1.4.3.21|KEGG: 00950+1.4.3.21|KEGG: 00960+1.4.3.21|MetaCyc: PWY-5751|Reactome: R-HSA-211945 TK78_RS15200 e81735cb4f379215ee91e1f84b316049 653 SUPERFAMILY SSF54416 13 105 2.98E-17 T 09-03-2017 IPR016182 Copper amine oxidase, N-terminal GO:0005507|GO:0008131|GO:0009308|GO:0048038|GO:0055114 Reactome: R-HSA-211945 TK78_RS15200 e81735cb4f379215ee91e1f84b316049 653 SUPERFAMILY SSF49998 220 638 1.96E-155 T 09-03-2017 IPR015798 Copper amine oxidase, C-terminal GO:0005507|GO:0008131|GO:0009308|GO:0048038|GO:0055114 Reactome: R-HSA-211945 TK78_RS15200 e81735cb4f379215ee91e1f84b316049 653 ProSitePatterns PS01164 Copper amine oxidase topaquinone signature. 381 394 - T 09-03-2017 IPR000269 Copper amine oxidase GO:0005507|GO:0008131|GO:0009308|GO:0048038|GO:0055114 Reactome: R-HSA-211945 TK78_RS15200 e81735cb4f379215ee91e1f84b316049 653 Pfam PF01179 Copper amine oxidase, enzyme domain 229 636 1.9E-153 T 09-03-2017 IPR015798 Copper amine oxidase, C-terminal GO:0005507|GO:0008131|GO:0009308|GO:0048038|GO:0055114 Reactome: R-HSA-211945 TK78_RS15200 e81735cb4f379215ee91e1f84b316049 653 Gene3D G3DSA:2.70.98.20 218 636 7.0E-168 T 09-03-2017 IPR015798 Copper amine oxidase, C-terminal GO:0005507|GO:0008131|GO:0009308|GO:0048038|GO:0055114 Reactome: R-HSA-211945 TK78_RS15200 e81735cb4f379215ee91e1f84b316049 653 ProSitePatterns PS01165 Copper amine oxidase copper-binding site signature. 597 610 - T 09-03-2017 IPR000269 Copper amine oxidase GO:0005507|GO:0008131|GO:0009308|GO:0048038|GO:0055114 Reactome: R-HSA-211945 TK78_RS15200 e81735cb4f379215ee91e1f84b316049 653 SUPERFAMILY SSF54416 106 214 2.54E-28 T 09-03-2017 IPR016182 Copper amine oxidase, N-terminal GO:0005507|GO:0008131|GO:0009308|GO:0048038|GO:0055114 Reactome: R-HSA-211945 TK78_RS15200 e81735cb4f379215ee91e1f84b316049 653 Gene3D G3DSA:3.10.450.40 112 212 2.7E-29 T 09-03-2017 TK78_RS11145 d761451b8dc38b39e24ecb9c4f0ca670 164 Pfam PF04075 Domain of unknown function (DUF385) 40 118 2.8E-6 T 09-03-2017 IPR004378 Deazaflavin-dependent nitroreductase/F420H(2)-dependent quinone reductase GO:0016491|GO:0055114 TK78_RS34840 e551aadf423b681c0ac84c209eaae6c1 439 Pfam PF03457 Helicase associated domain 139 207 3.1E-15 T 09-03-2017 IPR005114 Helicase-associated TK78_RS34840 e551aadf423b681c0ac84c209eaae6c1 439 Gene3D G3DSA:3.40.50.300 2 41 4.6E-4 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29315 04e4efdf5fa496cf66721888d26031e6 416 SUPERFAMILY SSF54631 292 409 8.97E-11 T 09-03-2017 TK78_RS29315 04e4efdf5fa496cf66721888d26031e6 416 PIRSF PIRSF006404 36 416 2.3E-104 T 09-03-2017 IPR016483 Uncharacterised conserved protein UCP006404, peptidase M50/CBS TK78_RS29315 04e4efdf5fa496cf66721888d26031e6 416 Pfam PF02163 Peptidase family M50 171 228 7.1E-8 T 09-03-2017 IPR008915 Peptidase M50 GO:0004222|GO:0006508 Reactome: R-HSA-1655829|Reactome: R-HSA-381033 TK78_RS29315 04e4efdf5fa496cf66721888d26031e6 416 Gene3D G3DSA:3.10.580.10 292 409 2.2E-10 T 09-03-2017 TK78_RS29315 04e4efdf5fa496cf66721888d26031e6 416 Pfam PF00571 CBS domain 293 338 0.0031 T 09-03-2017 IPR000644 CBS domain TK78_RS21025 90a3d47ecbd9813397094ea76b44c84b 1137 Pfam PF14685 Tricorn protease PDZ domain 816 902 7.6E-25 T 09-03-2017 IPR029414 Tricorn protease, PDZ domain TK78_RS21025 90a3d47ecbd9813397094ea76b44c84b 1137 PIRSF PIRSF036421 2 1120 0.0 T 09-03-2017 IPR012393 Tricorn protease GO:0008236 TK78_RS21025 90a3d47ecbd9813397094ea76b44c84b 1137 Gene3D G3DSA:2.120.10.60 3 276 2.8E-55 T 09-03-2017 TK78_RS21025 90a3d47ecbd9813397094ea76b44c84b 1137 Pfam PF14684 Tricorn protease C1 domain 734 801 1.3E-27 T 09-03-2017 IPR028204 Tricorn protease C1 domain TK78_RS21025 90a3d47ecbd9813397094ea76b44c84b 1137 Pfam PF03572 Peptidase family S41 931 1085 4.3E-22 T 09-03-2017 IPR005151 Tail specific protease GO:0006508|GO:0008236 Reactome: R-HSA-2187335|Reactome: R-HSA-2453902 TK78_RS21025 90a3d47ecbd9813397094ea76b44c84b 1137 SUPERFAMILY SSF52096 904 1110 1.66E-60 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS21025 90a3d47ecbd9813397094ea76b44c84b 1137 SUPERFAMILY SSF52096 731 810 1.66E-60 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS21025 90a3d47ecbd9813397094ea76b44c84b 1137 Gene3D G3DSA:3.30.750.44 731 801 8.6E-31 T 09-03-2017 TK78_RS21025 90a3d47ecbd9813397094ea76b44c84b 1137 SUPERFAMILY SSF69322 463 585 2.09E-19 T 09-03-2017 TK78_RS21025 90a3d47ecbd9813397094ea76b44c84b 1137 SUPERFAMILY SSF69322 298 415 2.09E-19 T 09-03-2017 TK78_RS21025 90a3d47ecbd9813397094ea76b44c84b 1137 SUPERFAMILY SSF50156 816 897 7.91E-14 T 09-03-2017 IPR001478 PDZ domain GO:0005515 TK78_RS21025 90a3d47ecbd9813397094ea76b44c84b 1137 Gene3D G3DSA:2.130.10.10 307 418 1.9E-86 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS21025 90a3d47ecbd9813397094ea76b44c84b 1137 Gene3D G3DSA:2.130.10.10 466 722 1.9E-86 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS21025 90a3d47ecbd9813397094ea76b44c84b 1137 SMART SM00245 895 1087 1.3E-12 T 09-03-2017 IPR005151 Tail specific protease GO:0006508|GO:0008236 Reactome: R-HSA-2187335|Reactome: R-HSA-2453902 TK78_RS21025 90a3d47ecbd9813397094ea76b44c84b 1137 Gene3D G3DSA:2.30.42.10 815 908 8.3E-30 T 09-03-2017 IPR001478 PDZ domain GO:0005515 TK78_RS21025 90a3d47ecbd9813397094ea76b44c84b 1137 SUPERFAMILY SSF69304 11 263 4.05E-23 T 09-03-2017 TK78_RS21025 90a3d47ecbd9813397094ea76b44c84b 1137 Gene3D G3DSA:3.90.226.10 911 1118 1.1E-35 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS21025 90a3d47ecbd9813397094ea76b44c84b 1137 Pfam PF07676 WD40-like Beta Propeller Repeat 518 550 1.6E-4 T 09-03-2017 IPR011659 WD40-like Beta Propeller TK78_RS21025 90a3d47ecbd9813397094ea76b44c84b 1137 Pfam PF07676 WD40-like Beta Propeller Repeat 54 70 0.014 T 09-03-2017 IPR011659 WD40-like Beta Propeller TK78_RS07030 c810acd56763b4e793631153ff0ec235 356 Pfam PF00483 Nucleotidyl transferase 2 235 3.8E-55 T 09-03-2017 IPR005835 Nucleotidyl transferase domain GO:0009058|GO:0016779 TK78_RS07030 c810acd56763b4e793631153ff0ec235 356 TIGRFAM TIGR01208 rmlA_long: glucose-1-phosphate thymidylyltransferase 2 353 5.6E-130 T 09-03-2017 IPR005908 Glucose-1-phosphate thymidylyltransferase, long form TK78_RS07030 c810acd56763b4e793631153ff0ec235 356 Gene3D G3DSA:3.90.550.10 1 288 1.5E-76 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS07030 c810acd56763b4e793631153ff0ec235 356 SUPERFAMILY SSF53448 1 289 3.6E-77 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS27125 7ec45b4c1eb4d8031fa33c6c872e55ce 239 Pfam PF01168 Alanine racemase, N-terminal domain 11 236 1.6E-23 T 09-03-2017 IPR001608 Alanine racemase, N-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TK78_RS27125 7ec45b4c1eb4d8031fa33c6c872e55ce 239 Gene3D G3DSA:3.20.20.10 2 236 3.2E-80 T 09-03-2017 IPR029066 PLP-binding barrel TK78_RS27125 7ec45b4c1eb4d8031fa33c6c872e55ce 239 ProSitePatterns PS01211 Uncharacterized protein family UPF0001 signature. 80 94 - T 09-03-2017 IPR011078 Uncharacterised protein family UPF0001 TK78_RS27125 7ec45b4c1eb4d8031fa33c6c872e55ce 239 TIGRFAM TIGR00044 TIGR00044: pyridoxal phosphate enzyme, YggS family 9 235 2.5E-44 T 09-03-2017 IPR011078 Uncharacterised protein family UPF0001 TK78_RS27125 7ec45b4c1eb4d8031fa33c6c872e55ce 239 PIRSF PIRSF004848 1 239 1.7E-66 T 09-03-2017 IPR011078 Uncharacterised protein family UPF0001 TK78_RS27125 7ec45b4c1eb4d8031fa33c6c872e55ce 239 SUPERFAMILY SSF51419 4 233 1.33E-61 T 09-03-2017 IPR029066 PLP-binding barrel TK78_RS21265 016d615c2c1988071d0b5e9595161205 250 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 156 170 8.9E-9 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS21265 016d615c2c1988071d0b5e9595161205 250 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 170 186 8.9E-9 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS21265 016d615c2c1988071d0b5e9595161205 250 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 186 198 8.9E-9 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS21265 016d615c2c1988071d0b5e9595161205 250 Pfam PF00072 Response regulator receiver domain 6 104 9.0E-6 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS21265 016d615c2c1988071d0b5e9595161205 250 Gene3D G3DSA:1.10.10.10 136 215 3.0E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS21265 016d615c2c1988071d0b5e9595161205 250 Gene3D G3DSA:3.40.50.2300 2 128 1.1E-12 T 09-03-2017 TK78_RS21265 016d615c2c1988071d0b5e9595161205 250 SUPERFAMILY SSF52172 2 123 1.99E-11 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS21265 016d615c2c1988071d0b5e9595161205 250 SUPERFAMILY SSF46894 141 216 2.04E-17 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS21265 016d615c2c1988071d0b5e9595161205 250 SMART SM00421 153 210 4.0E-17 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS21265 016d615c2c1988071d0b5e9595161205 250 Pfam PF00196 Bacterial regulatory proteins, luxR family 155 210 2.0E-14 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS32650 a8977f533ccd1d6ac2d604248f23c1c9 231 Gene3D G3DSA:3.40.50.1000 3 213 2.5E-32 T 09-03-2017 IPR023214 HAD-like domain TK78_RS32650 a8977f533ccd1d6ac2d604248f23c1c9 231 Pfam PF00702 haloacid dehalogenase-like hydrolase 3 195 4.3E-10 T 09-03-2017 TK78_RS32650 a8977f533ccd1d6ac2d604248f23c1c9 231 TIGRFAM TIGR01549 HAD-SF-IA-v1: HAD hydrolase, family IA, variant 1 114 202 2.6E-6 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS32650 a8977f533ccd1d6ac2d604248f23c1c9 231 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 3 14 1.9E-8 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS32650 a8977f533ccd1d6ac2d604248f23c1c9 231 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 125 138 1.9E-8 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS32650 a8977f533ccd1d6ac2d604248f23c1c9 231 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 200 213 1.9E-8 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS32650 a8977f533ccd1d6ac2d604248f23c1c9 231 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 173 193 1.9E-8 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS32650 a8977f533ccd1d6ac2d604248f23c1c9 231 SUPERFAMILY SSF56784 3 219 3.28E-33 T 09-03-2017 IPR023214 HAD-like domain TK78_RS01310 a44756691655bc02a105c2011a009c0f 363 TIGRFAM TIGR02050 gshA_cyan_rel: carboxylate-amine ligase, YbdK family 4 288 1.5E-96 T 09-03-2017 IPR011793 Putative glutamate--cysteine ligase YbdK GO:0016879 KEGG: 00270+6.3.2.2|KEGG: 00480+6.3.2.2|MetaCyc: PWY-6840|MetaCyc: PWY-7255 TK78_RS01310 a44756691655bc02a105c2011a009c0f 363 Hamap MF_01609 Glutamate--cysteine ligase [gshA]. 1 363 78.352 T 09-03-2017 IPR011793 Putative glutamate--cysteine ligase YbdK GO:0016879 KEGG: 00270+6.3.2.2|KEGG: 00480+6.3.2.2|MetaCyc: PWY-6840|MetaCyc: PWY-7255 TK78_RS01310 a44756691655bc02a105c2011a009c0f 363 Pfam PF04107 Glutamate-cysteine ligase family 2(GCS2) 5 283 3.3E-62 T 09-03-2017 IPR006336 Glutamate--cysteine ligase, GCS2 GO:0004357|GO:0042398 KEGG: 00270+6.3.2.2|KEGG: 00480+6.3.2.2|MetaCyc: PWY-6840|MetaCyc: PWY-7255 TK78_RS01310 a44756691655bc02a105c2011a009c0f 363 SUPERFAMILY SSF55931 3 360 5.59E-92 T 09-03-2017 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 SMART SM00304 10 62 14.0 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 SMART SM00304 1032 1084 2.5E-8 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 SMART SM00304 940 992 8.3E-11 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 SMART SM00304 756 808 4.1E-8 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 SMART SM00304 388 440 1.4E-7 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 SMART SM00304 296 348 1.7E-11 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 SMART SM00304 204 256 2.6E-5 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 SMART SM00304 102 164 0.0069 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 SMART SM00304 572 624 7.6E-11 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 SMART SM00304 480 532 4.8E-9 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 SMART SM00304 664 716 5.3E-11 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 SMART SM00304 848 900 1.9E-9 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 Pfam PF00072 Response regulator receiver domain 1700 1811 4.7E-26 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 Pfam PF00672 HAMP domain 662 712 2.0E-6 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 Pfam PF00672 HAMP domain 569 620 1.2E-6 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 Pfam PF00672 HAMP domain 939 988 1.2E-6 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 Pfam PF00672 HAMP domain 294 344 1.4E-8 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 Pfam PF00672 HAMP domain 845 895 2.1E-6 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1548 1566 1.5E-16 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1513 1527 1.5E-16 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1531 1541 1.5E-16 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1572 1585 1.5E-16 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 SUPERFAMILY SSF58104 960 1082 4.45E-9 T 09-03-2017 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 Pfam PF00512 His Kinase A (phospho-acceptor) domain 1341 1408 4.4E-18 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 SMART SM00065 1108 1265 6.7E-8 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 SUPERFAMILY SSF55874 1397 1590 1.57E-43 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 SUPERFAMILY SSF47384 1326 1410 5.1E-21 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 Gene3D G3DSA:3.30.565.10 1394 1589 8.2E-43 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 SMART SM00448 1698 1812 1.0E-36 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 SUPERFAMILY SSF58104 684 957 4.71E-19 T 09-03-2017 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 SMART SM00388 1340 1408 1.1E-23 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 SUPERFAMILY SSF58104 224 357 9.29E-11 T 09-03-2017 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 SUPERFAMILY SSF52172 1692 1817 6.4E-37 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 Pfam PF13185 GAF domain 1107 1253 3.7E-17 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 Gene3D G3DSA:3.30.450.40 1091 1255 5.4E-21 T 09-03-2017 IPR029016 GAF domain-like TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 SUPERFAMILY SSF58104 316 446 1.1E-10 T 09-03-2017 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 SMART SM00387 1455 1588 2.7E-36 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 Gene3D G3DSA:3.40.50.2300 1693 1817 1.0E-39 T 09-03-2017 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 SUPERFAMILY SSF58104 500 631 6.63E-11 T 09-03-2017 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 SUPERFAMILY SSF55781 1071 1255 1.69E-25 T 09-03-2017 IPR029016 GAF domain-like TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 Gene3D G3DSA:1.10.287.130 1331 1393 3.8E-16 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS07605 0428aa3818c58e2cb0fa29d09c896228 1819 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 1455 1587 3.3E-26 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS03510 e793d0eb2db0d530cd53ba6fd64c39c0 328 Pfam PF00005 ABC transporter 21 168 1.4E-25 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS03510 e793d0eb2db0d530cd53ba6fd64c39c0 328 SMART SM00382 29 225 4.1E-14 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS03510 e793d0eb2db0d530cd53ba6fd64c39c0 328 Gene3D G3DSA:3.40.50.300 5 232 4.4E-59 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03510 e793d0eb2db0d530cd53ba6fd64c39c0 328 SUPERFAMILY SSF52540 7 231 7.1E-57 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03510 e793d0eb2db0d530cd53ba6fd64c39c0 328 ProSitePatterns PS00211 ABC transporters family signature. 141 155 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 SUPERFAMILY SSF52777 3652 3860 1.22E-40 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 SUPERFAMILY SSF52777 3849 4112 3.78E-64 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 ProSitePatterns PS00455 Putative AMP-binding domain signature. 3195 3206 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 TIGRFAM TIGR01720 NRPS-para261: non-ribosomal peptide synthase domain TIGR01720 5018 5177 5.7E-34 T 09-03-2017 IPR010060 Non-ribosomal peptide synthase TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 TIGRFAM TIGR01720 NRPS-para261: non-ribosomal peptide synthase domain TIGR01720 2447 2593 5.0E-22 T 09-03-2017 IPR010060 Non-ribosomal peptide synthase TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Pfam PF13193 AMP-binding enzyme C-terminal domain 3468 3543 1.7E-9 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Pfam PF13193 AMP-binding enzyme C-terminal domain 4530 4606 1.7E-9 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Pfam PF13193 AMP-binding enzyme C-terminal domain 1968 2043 9.9E-8 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Pfam PF13193 AMP-binding enzyme C-terminal domain 911 982 4.0E-8 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Gene3D G3DSA:3.30.300.30 1954 2054 7.3E-31 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 ProSitePatterns PS00455 Putative AMP-binding domain signature. 4267 4278 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 SUPERFAMILY SSF52777 7 215 1.02E-45 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 SUPERFAMILY SSF52777 2603 2796 4.22E-39 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 SMART SM00823 Phosphopantetheine attachment site 2066 2135 4.2E-10 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 SMART SM00823 Phosphopantetheine attachment site 3570 3639 2.1E-5 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 SMART SM00823 Phosphopantetheine attachment site 4632 4700 0.0013 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 SMART SM00823 Phosphopantetheine attachment site 1007 1076 5.7E-5 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 SUPERFAMILY SSF52777 1283 1530 1.56E-61 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Gene3D G3DSA:2.30.38.10 4435 4512 3.4E-24 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Gene3D G3DSA:2.30.38.10 810 889 5.3E-25 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Gene3D G3DSA:2.30.38.10 3373 3449 9.1E-26 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Gene3D G3DSA:2.30.38.10 1872 1950 8.5E-25 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Pfam PF00501 AMP-binding enzyme 4127 4522 3.8E-89 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Pfam PF00501 AMP-binding enzyme 483 900 4.4E-89 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Pfam PF00501 AMP-binding enzyme 1563 1960 9.5E-92 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Pfam PF00501 AMP-binding enzyme 3056 3460 4.6E-79 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2091 2106 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 SUPERFAMILY SSF52777 4885 5155 2.22E-27 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 ProSitePatterns PS00455 Putative AMP-binding domain signature. 630 641 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Gene3D G3DSA:3.40.50.980 3056 3217 2.3E-31 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Gene3D G3DSA:3.40.50.980 476 638 3.7E-36 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Gene3D G3DSA:3.40.50.980 4123 4288 9.6E-38 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Gene3D G3DSA:3.40.50.980 1557 1728 1.8E-43 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 SUPERFAMILY SSF56801 1521 2078 3.27E-147 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 SUPERFAMILY SSF52777 4708 4898 5.45E-28 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 SUPERFAMILY SSF47336 1000 1072 9.68E-19 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Pfam PF13745 HxxPF-repeated domain 3981 4073 2.0E-30 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Pfam PF13745 HxxPF-repeated domain 1416 1507 7.7E-31 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Gene3D G3DSA:3.40.50.980 3218 3372 2.6E-37 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Gene3D G3DSA:3.40.50.980 4289 4434 1.3E-41 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Gene3D G3DSA:3.40.50.980 1730 1871 4.9E-39 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 SUPERFAMILY SSF52777 2149 2344 5.67E-28 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1031 1046 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 SUPERFAMILY SSF56801 4086 4645 7.46E-147 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 SUPERFAMILY SSF52777 201 452 6.34E-48 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 SUPERFAMILY SSF52777 2782 3026 1.22E-50 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 SUPERFAMILY SSF47336 2061 2131 1.7E-15 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Gene3D G3DSA:1.10.1200.10 1012 1074 9.5E-26 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Gene3D G3DSA:1.10.1200.10 2055 2135 6.3E-21 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Gene3D G3DSA:1.10.1200.10 4637 4700 4.9E-22 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Gene3D G3DSA:1.10.1200.10 3574 3639 1.2E-19 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 SUPERFAMILY SSF47336 3563 3635 1.96E-15 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Pfam PF00550 Phosphopantetheine attachment site 3572 3635 1.2E-10 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Pfam PF00550 Phosphopantetheine attachment site 2068 2130 9.2E-13 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Pfam PF00550 Phosphopantetheine attachment site 1010 1072 2.6E-14 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Pfam PF00550 Phosphopantetheine attachment site 4634 4694 1.4E-10 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Gene3D G3DSA:3.30.300.30 895 1011 2.5E-33 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Gene3D G3DSA:3.30.300.30 4517 4636 4.0E-30 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Gene3D G3DSA:3.30.300.30 3455 3573 1.9E-32 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 SUPERFAMILY SSF47336 4626 4694 8.64E-15 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Pfam PF00668 Condensation domain 2165 2442 1.1E-30 T 09-03-2017 IPR001242 Condensation domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Pfam PF00668 Condensation domain 2604 2894 3.0E-56 T 09-03-2017 IPR001242 Condensation domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Pfam PF00668 Condensation domain 4713 5002 1.8E-31 T 09-03-2017 IPR001242 Condensation domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Pfam PF00668 Condensation domain 1091 1394 6.4E-56 T 09-03-2017 IPR001242 Condensation domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Pfam PF00668 Condensation domain 3656 3959 1.4E-56 T 09-03-2017 IPR001242 Condensation domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Pfam PF00668 Condensation domain 8 315 3.0E-62 T 09-03-2017 IPR001242 Condensation domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 SUPERFAMILY SSF56801 3052 3583 4.97E-127 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 SUPERFAMILY SSF52777 1093 1267 8.67E-47 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 1591 1983 9.1E-133 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 4149 4546 1.6E-123 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 502 924 3.4E-120 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 3078 3484 4.8E-115 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 ProSitePatterns PS00455 Putative AMP-binding domain signature. 1707 1718 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 SUPERFAMILY SSF52777 2330 2571 1.7E-30 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 Gene3D G3DSA:3.40.50.980 639 802 1.0E-47 T 09-03-2017 TK78_RS01265 4819ce289bc9533c69480a0c0c9f8f56 5185 SUPERFAMILY SSF56801 475 1018 1.83E-143 T 09-03-2017 TK78_RS02320 a1171e90b57456ce60ea5170fc1ec0dd 687 Gene3D G3DSA:3.30.565.10 572 682 3.3E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS02320 a1171e90b57456ce60ea5170fc1ec0dd 687 SUPERFAMILY SSF55785 28 133 4.71E-15 T 09-03-2017 IPR000014 PAS domain TK78_RS02320 a1171e90b57456ce60ea5170fc1ec0dd 687 SMART SM00086 92 134 4.1E-7 T 09-03-2017 IPR001610 PAC motif TK78_RS02320 a1171e90b57456ce60ea5170fc1ec0dd 687 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 363 550 7.8E-47 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS02320 a1171e90b57456ce60ea5170fc1ec0dd 687 SUPERFAMILY SSF81606 348 549 1.09E-11 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS02320 a1171e90b57456ce60ea5170fc1ec0dd 687 SMART SM00331 334 550 5.6E-32 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS02320 a1171e90b57456ce60ea5170fc1ec0dd 687 Pfam PF08447 PAS fold 40 128 1.1E-12 T 09-03-2017 IPR013655 PAS fold-3 GO:0005515 TK78_RS02320 a1171e90b57456ce60ea5170fc1ec0dd 687 Gene3D G3DSA:3.30.450.40 180 320 4.0E-15 T 09-03-2017 IPR029016 GAF domain-like TK78_RS02320 a1171e90b57456ce60ea5170fc1ec0dd 687 SUPERFAMILY SSF55781 184 319 2.09E-15 T 09-03-2017 IPR029016 GAF domain-like TK78_RS02320 a1171e90b57456ce60ea5170fc1ec0dd 687 Pfam PF13185 GAF domain 190 306 6.5E-10 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS02320 a1171e90b57456ce60ea5170fc1ec0dd 687 Pfam PF13581 Histidine kinase-like ATPase domain 569 679 1.6E-10 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS02320 a1171e90b57456ce60ea5170fc1ec0dd 687 Gene3D G3DSA:3.30.450.20 28 131 8.7E-16 T 09-03-2017 TK78_RS02320 a1171e90b57456ce60ea5170fc1ec0dd 687 SMART SM00065 163 316 1.4E-6 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS02320 a1171e90b57456ce60ea5170fc1ec0dd 687 SUPERFAMILY SSF55874 591 682 6.02E-8 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS02320 a1171e90b57456ce60ea5170fc1ec0dd 687 Gene3D G3DSA:3.60.40.10 476 548 6.5E-7 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS02320 a1171e90b57456ce60ea5170fc1ec0dd 687 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 68 134 2.4E-7 T 09-03-2017 IPR000014 PAS domain TK78_RS13415 8d031296ed8957668fd67a9d16715d71 456 SUPERFAMILY SSF143243 40 174 1.07E-37 T 09-03-2017 TK78_RS13415 8d031296ed8957668fd67a9d16715d71 456 ProDom PD001581 OXIDOREDUCTASE SUBUNIT NADH DEHYDROGENASE CHAIN C NAD DEHYDROGENASE UBIQUINONE F420H2 99 155 1.0E-19 T 09-03-2017 IPR001268 NADH:ubiquinone oxidoreductase, 30kDa subunit GO:0008137|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13415 8d031296ed8957668fd67a9d16715d71 456 Pfam PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 48 167 3.1E-34 T 09-03-2017 IPR001268 NADH:ubiquinone oxidoreductase, 30kDa subunit GO:0008137|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS12885 c422f67b282355cc2802c7bfaec25a99 71 Pfam PF09957 Bacterial antitoxin of type II TA system, VapB 2 41 2.0E-11 T 09-03-2017 IPR019239 Bacterial antitoxin of type II TA system, VapB TK78_RS14655 32ffcbe04a60503dcc6ca14071816b2d 477 Pfam PF07690 Major Facilitator Superfamily 83 430 7.3E-14 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS14655 32ffcbe04a60503dcc6ca14071816b2d 477 SUPERFAMILY SSF103473 273 457 2.09E-20 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS14655 32ffcbe04a60503dcc6ca14071816b2d 477 SUPERFAMILY SSF103473 85 241 2.09E-20 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS14655 32ffcbe04a60503dcc6ca14071816b2d 477 Gene3D G3DSA:1.20.1250.20 87 238 1.4E-7 T 09-03-2017 TK78_RS30300 6bb9e1bec4c8174a7d2d63938df13a59 328 Pfam PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 163 309 3.4E-23 T 09-03-2017 IPR006131 Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain GO:0006520|GO:0016597|GO:0016743 TK78_RS30300 6bb9e1bec4c8174a7d2d63938df13a59 328 SUPERFAMILY SSF53671 2 312 6.81E-93 T 09-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TK78_RS30300 6bb9e1bec4c8174a7d2d63938df13a59 328 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 275 298 2.3E-20 T 09-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TK78_RS30300 6bb9e1bec4c8174a7d2d63938df13a59 328 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 135 146 2.3E-20 T 09-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TK78_RS30300 6bb9e1bec4c8174a7d2d63938df13a59 328 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 49 68 2.3E-20 T 09-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TK78_RS30300 6bb9e1bec4c8174a7d2d63938df13a59 328 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 263 272 2.3E-20 T 09-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TK78_RS30300 6bb9e1bec4c8174a7d2d63938df13a59 328 Gene3D G3DSA:3.40.50.1370 143 288 8.3E-49 T 09-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TK78_RS30300 6bb9e1bec4c8174a7d2d63938df13a59 328 PRINTS PR00101 Aspartate carbamoyltransferase signature 291 305 1.1E-30 T 09-03-2017 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|Reactome: R-HSA-500753 TK78_RS30300 6bb9e1bec4c8174a7d2d63938df13a59 328 PRINTS PR00101 Aspartate carbamoyltransferase signature 77 86 1.1E-30 T 09-03-2017 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|Reactome: R-HSA-500753 TK78_RS30300 6bb9e1bec4c8174a7d2d63938df13a59 328 PRINTS PR00101 Aspartate carbamoyltransferase signature 226 235 1.1E-30 T 09-03-2017 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|Reactome: R-HSA-500753 TK78_RS30300 6bb9e1bec4c8174a7d2d63938df13a59 328 PRINTS PR00101 Aspartate carbamoyltransferase signature 39 61 1.1E-30 T 09-03-2017 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|Reactome: R-HSA-500753 TK78_RS30300 6bb9e1bec4c8174a7d2d63938df13a59 328 PRINTS PR00101 Aspartate carbamoyltransferase signature 134 151 1.1E-30 T 09-03-2017 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|Reactome: R-HSA-500753 TK78_RS30300 6bb9e1bec4c8174a7d2d63938df13a59 328 PRINTS PR00101 Aspartate carbamoyltransferase signature 267 272 1.1E-30 T 09-03-2017 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|Reactome: R-HSA-500753 TK78_RS30300 6bb9e1bec4c8174a7d2d63938df13a59 328 Hamap MF_00001 Aspartate carbamoyltransferase [pyrB]. 2 312 41.286 T 09-03-2017 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|Reactome: R-HSA-500753 TK78_RS30300 6bb9e1bec4c8174a7d2d63938df13a59 328 Gene3D G3DSA:3.40.50.1370 2 142 4.8E-49 T 09-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TK78_RS30300 6bb9e1bec4c8174a7d2d63938df13a59 328 ProSitePatterns PS00097 Aspartate and ornithine carbamoyltransferases signature. 49 56 - T 09-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TK78_RS30300 6bb9e1bec4c8174a7d2d63938df13a59 328 Pfam PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 3 147 3.3E-39 T 09-03-2017 IPR006132 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding GO:0006520|GO:0016743 TK78_RS30300 6bb9e1bec4c8174a7d2d63938df13a59 328 TIGRFAM TIGR00670 asp_carb_tr: aspartate carbamoyltransferase 3 310 8.8E-92 T 09-03-2017 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|Reactome: R-HSA-500753 TK78_RS09040 b2f6c9eaae59d24f94879b3290a5b736 434 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 178 191 1.3E-6 T 09-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TK78_RS09040 b2f6c9eaae59d24f94879b3290a5b736 434 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 46 64 1.3E-6 T 09-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TK78_RS09040 b2f6c9eaae59d24f94879b3290a5b736 434 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 265 284 1.3E-6 T 09-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TK78_RS09040 b2f6c9eaae59d24f94879b3290a5b736 434 ProSitePatterns PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 215 230 - T 09-03-2017 IPR022657 Orn/DAP/Arg decarboxylase 2, conserved site TK78_RS09040 b2f6c9eaae59d24f94879b3290a5b736 434 Gene3D G3DSA:3.20.20.10 26 256 1.9E-59 T 09-03-2017 IPR029066 PLP-binding barrel TK78_RS09040 b2f6c9eaae59d24f94879b3290a5b736 434 Pfam PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 282 395 2.1E-10 T 09-03-2017 IPR022643 Orn/DAP/Arg decarboxylase 2, C-terminal GO:0003824 TK78_RS09040 b2f6c9eaae59d24f94879b3290a5b736 434 Pfam PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 32 275 3.3E-40 T 09-03-2017 IPR022644 Orn/DAP/Arg decarboxylase 2, N-terminal GO:0003824 TK78_RS09040 b2f6c9eaae59d24f94879b3290a5b736 434 PRINTS PR01181 Diaminopimelate decarboxylase signature 64 81 2.7E-6 T 09-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS09040 b2f6c9eaae59d24f94879b3290a5b736 434 PRINTS PR01181 Diaminopimelate decarboxylase signature 385 407 2.7E-6 T 09-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS09040 b2f6c9eaae59d24f94879b3290a5b736 434 PRINTS PR01181 Diaminopimelate decarboxylase signature 152 161 2.7E-6 T 09-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS09040 b2f6c9eaae59d24f94879b3290a5b736 434 Gene3D G3DSA:2.40.37.10 257 419 5.1E-34 T 09-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 TK78_RS09040 b2f6c9eaae59d24f94879b3290a5b736 434 SUPERFAMILY SSF50621 255 419 2.07E-34 T 09-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 TK78_RS09040 b2f6c9eaae59d24f94879b3290a5b736 434 SUPERFAMILY SSF51419 16 277 5.23E-62 T 09-03-2017 IPR029066 PLP-binding barrel TK78_RS33590 1b42ceaa30d219e222d61e7aacfd0ada 292 Gene3D G3DSA:3.90.1200.10 89 229 1.6E-10 T 09-03-2017 TK78_RS33590 1b42ceaa30d219e222d61e7aacfd0ada 292 Pfam PF01636 Phosphotransferase enzyme family 38 227 2.5E-11 T 09-03-2017 IPR002575 Aminoglycoside phosphotransferase TK78_RS33590 1b42ceaa30d219e222d61e7aacfd0ada 292 SUPERFAMILY SSF56112 36 272 2.19E-15 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS14445 42164da0dcdad0f54cc73414695c8ba8 310 Pfam PF03466 LysR substrate binding domain 102 293 1.7E-15 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS14445 42164da0dcdad0f54cc73414695c8ba8 310 Gene3D G3DSA:3.40.190.10 102 192 2.1E-11 T 09-03-2017 TK78_RS14445 42164da0dcdad0f54cc73414695c8ba8 310 SUPERFAMILY SSF46785 2 84 5.44E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS14445 42164da0dcdad0f54cc73414695c8ba8 310 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 1.1E-7 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS14445 42164da0dcdad0f54cc73414695c8ba8 310 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 1.1E-7 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS14445 42164da0dcdad0f54cc73414695c8ba8 310 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 1.1E-7 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS14445 42164da0dcdad0f54cc73414695c8ba8 310 Gene3D G3DSA:1.10.10.10 2 83 6.4E-28 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS14445 42164da0dcdad0f54cc73414695c8ba8 310 SUPERFAMILY SSF53850 102 298 1.21E-19 T 09-03-2017 TK78_RS14445 42164da0dcdad0f54cc73414695c8ba8 310 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 4 62 5.5E-21 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS03940 bc1d1d3f941473423457fe5cc0751e94 412 SUPERFAMILY SSF55347 159 330 1.96E-35 T 09-03-2017 TK78_RS03940 bc1d1d3f941473423457fe5cc0751e94 412 Gene3D G3DSA:3.30.360.10 174 311 5.1E-51 T 09-03-2017 TK78_RS03940 bc1d1d3f941473423457fe5cc0751e94 412 Gene3D G3DSA:3.30.360.10 359 402 5.1E-51 T 09-03-2017 TK78_RS03940 bc1d1d3f941473423457fe5cc0751e94 412 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 25 148 1.4E-23 T 09-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 TK78_RS03940 bc1d1d3f941473423457fe5cc0751e94 412 Gene3D G3DSA:3.40.50.720 19 173 1.6E-48 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS03940 bc1d1d3f941473423457fe5cc0751e94 412 SUPERFAMILY SSF51735 19 185 1.86E-48 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS03940 bc1d1d3f941473423457fe5cc0751e94 412 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 165 234 9.4E-10 T 09-03-2017 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 TK78_RS11515 12802c873f5470f07a5a13b0c63b546b 440 Gene3D G3DSA:3.40.50.300 229 435 1.1E-51 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS11515 12802c873f5470f07a5a13b0c63b546b 440 SMART SM00670 13 140 1.6E-12 T 09-03-2017 IPR002716 PIN domain TK78_RS11515 12802c873f5470f07a5a13b0c63b546b 440 Pfam PF13638 PIN domain 15 153 5.9E-25 T 09-03-2017 IPR002716 PIN domain TK78_RS11515 12802c873f5470f07a5a13b0c63b546b 440 Gene3D G3DSA:3.40.50.1010 105 153 1.1E-9 T 09-03-2017 IPR029060 PIN domain-like TK78_RS11515 12802c873f5470f07a5a13b0c63b546b 440 Gene3D G3DSA:3.40.50.1010 14 72 1.1E-9 T 09-03-2017 IPR029060 PIN domain-like TK78_RS11515 12802c873f5470f07a5a13b0c63b546b 440 SUPERFAMILY SSF52540 229 392 6.76E-19 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS11515 12802c873f5470f07a5a13b0c63b546b 440 SUPERFAMILY SSF88723 105 151 7.57E-8 T 09-03-2017 IPR029060 PIN domain-like TK78_RS11515 12802c873f5470f07a5a13b0c63b546b 440 SUPERFAMILY SSF88723 14 72 7.57E-8 T 09-03-2017 IPR029060 PIN domain-like TK78_RS11515 12802c873f5470f07a5a13b0c63b546b 440 Pfam PF02562 PhoH-like protein 230 435 6.7E-54 T 09-03-2017 IPR003714 PhoH-like protein GO:0005524 TK78_RS02310 24792596537dd04ab619ca187a641ecd 286 SMART SM01232 136 228 1.0E-30 T 09-03-2017 IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding GO:0003684|GO:0003906|GO:0006289|GO:0008270|GO:0016799 TK78_RS02310 24792596537dd04ab619ca187a641ecd 286 Pfam PF06831 Formamidopyrimidine-DNA glycosylase H2TH domain 136 219 4.6E-20 T 09-03-2017 IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding GO:0003684|GO:0003906|GO:0006289|GO:0008270|GO:0016799 TK78_RS02310 24792596537dd04ab619ca187a641ecd 286 SUPERFAMILY SSF57716 230 271 1.2E-10 T 09-03-2017 TK78_RS02310 24792596537dd04ab619ca187a641ecd 286 SUPERFAMILY SSF81624 2 145 4.32E-24 T 09-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 TK78_RS02310 24792596537dd04ab619ca187a641ecd 286 Gene3D G3DSA:3.20.190.10 2 136 1.6E-18 T 09-03-2017 TK78_RS02310 24792596537dd04ab619ca187a641ecd 286 Pfam PF06827 Zinc finger found in FPG and IleRS 243 270 2.3E-7 T 09-03-2017 IPR010663 Zinc finger, FPG/IleRS-type Reactome: R-HSA-379726 TK78_RS02310 24792596537dd04ab619ca187a641ecd 286 Pfam PF01149 Formamidopyrimidine-DNA glycosylase N-terminal domain 1 86 5.9E-15 T 09-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 TK78_RS02310 24792596537dd04ab619ca187a641ecd 286 SMART SM00898 2 122 5.4E-23 T 09-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 TK78_RS02310 24792596537dd04ab619ca187a641ecd 286 Gene3D G3DSA:1.10.8.50 137 271 2.3E-36 T 09-03-2017 TK78_RS02310 24792596537dd04ab619ca187a641ecd 286 SUPERFAMILY SSF46946 136 219 2.36E-24 T 09-03-2017 IPR010979 Ribosomal protein S13-like, H2TH GO:0003676 TK78_RS17765 c4b2d5437bd1abcd6863a765b11e6d91 263 Pfam PF00795 Carbon-nitrogen hydrolase 3 246 2.8E-49 T 09-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 TK78_RS17765 c4b2d5437bd1abcd6863a765b11e6d91 263 ProSitePatterns PS01227 Uncharacterized protein family UPF0012 signature. 142 162 - T 09-03-2017 IPR001110 Uncharacterised protein family UPF0012, conserved site TK78_RS17765 c4b2d5437bd1abcd6863a765b11e6d91 263 Gene3D G3DSA:3.60.110.10 1 259 1.9E-76 T 09-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 TK78_RS17765 c4b2d5437bd1abcd6863a765b11e6d91 263 SUPERFAMILY SSF56317 1 254 1.83E-71 T 09-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 TK78_RS29600 fdbdd4a2db2ab961ecb3a512ab8a9755 385 Pfam PF00989 PAS fold 41 83 3.5E-5 T 09-03-2017 IPR013767 PAS fold GO:0006355 TK78_RS29600 fdbdd4a2db2ab961ecb3a512ab8a9755 385 Gene3D G3DSA:3.30.565.10 209 379 1.4E-39 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS29600 fdbdd4a2db2ab961ecb3a512ab8a9755 385 SUPERFAMILY SSF55874 213 379 2.75E-39 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS29600 fdbdd4a2db2ab961ecb3a512ab8a9755 385 Gene3D G3DSA:1.10.287.130 148 208 6.3E-16 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS29600 fdbdd4a2db2ab961ecb3a512ab8a9755 385 SMART SM00388 155 223 2.8E-17 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS29600 fdbdd4a2db2ab961ecb3a512ab8a9755 385 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 269 378 1.3E-23 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS29600 fdbdd4a2db2ab961ecb3a512ab8a9755 385 Pfam PF00512 His Kinase A (phospho-acceptor) domain 157 223 1.7E-15 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS29600 fdbdd4a2db2ab961ecb3a512ab8a9755 385 SUPERFAMILY SSF47384 146 224 2.35E-16 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS29600 fdbdd4a2db2ab961ecb3a512ab8a9755 385 Gene3D G3DSA:3.30.450.20 40 93 1.2E-11 T 09-03-2017 TK78_RS29600 fdbdd4a2db2ab961ecb3a512ab8a9755 385 PRINTS PR00344 Bacterial sensor protein C-terminal signature 328 338 4.0E-15 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS29600 fdbdd4a2db2ab961ecb3a512ab8a9755 385 PRINTS PR00344 Bacterial sensor protein C-terminal signature 340 358 4.0E-15 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS29600 fdbdd4a2db2ab961ecb3a512ab8a9755 385 PRINTS PR00344 Bacterial sensor protein C-terminal signature 364 377 4.0E-15 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS29600 fdbdd4a2db2ab961ecb3a512ab8a9755 385 PRINTS PR00344 Bacterial sensor protein C-terminal signature 310 324 4.0E-15 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS29600 fdbdd4a2db2ab961ecb3a512ab8a9755 385 SMART SM00387 268 380 1.6E-37 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS29600 fdbdd4a2db2ab961ecb3a512ab8a9755 385 SUPERFAMILY SSF55785 40 129 1.13E-10 T 09-03-2017 IPR000014 PAS domain TK78_RS29275 17128823bb600fd9012cceeb2395a9d7 514 ProSitePatterns PS00445 FGGY family of carbohydrate kinases signature 2. 374 394 - T 09-03-2017 IPR018483 Carbohydrate kinase, FGGY, conserved site GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 TK78_RS29275 17128823bb600fd9012cceeb2395a9d7 514 Gene3D G3DSA:3.30.420.40 13 264 1.6E-107 T 09-03-2017 TK78_RS29275 17128823bb600fd9012cceeb2395a9d7 514 Hamap MF_00186 Glycerol kinase [glpK]. 13 509 55.852 T 09-03-2017 IPR005999 Glycerol kinase GO:0004370|GO:0006072 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|Reactome: R-HSA-75109 TK78_RS29275 17128823bb600fd9012cceeb2395a9d7 514 Gene3D G3DSA:3.30.420.40 266 510 2.2E-102 T 09-03-2017 TK78_RS29275 17128823bb600fd9012cceeb2395a9d7 514 PIRSF PIRSF000538 13 514 3.8E-168 T 09-03-2017 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 TK78_RS29275 17128823bb600fd9012cceeb2395a9d7 514 SUPERFAMILY SSF53067 266 509 1.19E-82 T 09-03-2017 TK78_RS29275 17128823bb600fd9012cceeb2395a9d7 514 TIGRFAM TIGR01311 glycerol_kin: glycerol kinase 14 508 1.4E-226 T 09-03-2017 IPR005999 Glycerol kinase GO:0004370|GO:0006072 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|Reactome: R-HSA-75109 TK78_RS29275 17128823bb600fd9012cceeb2395a9d7 514 SUPERFAMILY SSF53067 15 266 1.5E-91 T 09-03-2017 TK78_RS29275 17128823bb600fd9012cceeb2395a9d7 514 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 16 263 2.2E-80 T 09-03-2017 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 TK78_RS29275 17128823bb600fd9012cceeb2395a9d7 514 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 272 462 2.2E-66 T 09-03-2017 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 TK78_RS18045 02595276b20df35d864fc4e5ad38c225 196 SUPERFAMILY SSF51161 4 166 1.16E-39 T 09-03-2017 IPR011004 Trimeric LpxA-like TK78_RS18045 02595276b20df35d864fc4e5ad38c225 196 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 70 106 0.0013 T 09-03-2017 IPR001451 Hexapeptide repeat TK78_RS18045 02595276b20df35d864fc4e5ad38c225 196 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 123 157 1.9E-8 T 09-03-2017 IPR001451 Hexapeptide repeat TK78_RS18045 02595276b20df35d864fc4e5ad38c225 196 Gene3D G3DSA:1.10.3130.10 2 58 5.1E-15 T 09-03-2017 TK78_RS18045 02595276b20df35d864fc4e5ad38c225 196 ProSitePatterns PS00101 Hexapeptide-repeat containing-transferases signature. 132 160 - T 09-03-2017 IPR018357 Hexapeptide transferase, conserved site GO:0016740 Reactome: R-HSA-446205 TK78_RS18045 02595276b20df35d864fc4e5ad38c225 196 Gene3D G3DSA:2.160.10.10 59 175 4.5E-29 T 09-03-2017 TK78_RS18045 02595276b20df35d864fc4e5ad38c225 196 PIRSF PIRSF000441 1 188 2.9E-55 T 09-03-2017 IPR005881 Serine O-acetyltransferase GO:0005737|GO:0006535|GO:0009001 KEGG: 00270+2.3.1.30|KEGG: 00920+2.3.1.30|MetaCyc: PWY-6936|MetaCyc: PWY-7274 TK78_RS23105 ce0ebdffac0ae83884bb3443f5bd4a79 380 SUPERFAMILY SSF51679 34 372 1.3E-78 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS23105 ce0ebdffac0ae83884bb3443f5bd4a79 380 TIGRFAM TIGR03558 oxido_grp_1: luciferase family oxidoreductase, group 1 35 373 5.4E-131 T 09-03-2017 IPR019949 Luciferase family oxidoreductase, group 1 TK78_RS23105 ce0ebdffac0ae83884bb3443f5bd4a79 380 Gene3D G3DSA:3.20.20.30 34 372 2.4E-92 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS23105 ce0ebdffac0ae83884bb3443f5bd4a79 380 Pfam PF00296 Luciferase-like monooxygenase 37 349 3.9E-41 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS12190 25c677470ac1c6987c9e5e4f5a99a400 348 SUPERFAMILY SSF53822 51 298 7.33E-12 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS12190 25c677470ac1c6987c9e5e4f5a99a400 348 Gene3D G3DSA:3.40.50.2300 39 161 1.7E-43 T 09-03-2017 TK78_RS12190 25c677470ac1c6987c9e5e4f5a99a400 348 Pfam PF02608 Basic membrane protein 45 338 4.9E-52 T 09-03-2017 IPR003760 ABC transporter substrate-binding protein PnrA-like GO:0005886 TK78_RS12190 25c677470ac1c6987c9e5e4f5a99a400 348 Gene3D G3DSA:3.40.50.2300 162 274 2.6E-4 T 09-03-2017 TK78_RS08985 835ee3a96048531d6b50c28debba8df8 419 SUPERFAMILY SSF53383 3 416 1.9E-172 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS08985 835ee3a96048531d6b50c28debba8df8 419 Pfam PF00464 Serine hydroxymethyltransferase 9 388 3.9E-163 T 09-03-2017 IPR001085 Serine hydroxymethyltransferase GO:0016740 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 TK78_RS08985 835ee3a96048531d6b50c28debba8df8 419 PIRSF PIRSF000412 1 412 5.5E-156 T 09-03-2017 IPR001085 Serine hydroxymethyltransferase GO:0016740 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 TK78_RS08985 835ee3a96048531d6b50c28debba8df8 419 Hamap MF_00051 Serine hydroxymethyltransferase [glyA]. 7 416 50.478 T 09-03-2017 IPR001085 Serine hydroxymethyltransferase GO:0016740 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 TK78_RS08985 835ee3a96048531d6b50c28debba8df8 419 ProSitePatterns PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 221 237 - T 09-03-2017 IPR019798 Serine hydroxymethyltransferase, pyridoxal phosphate binding site GO:0004372|GO:0006544|GO:0006563|GO:0030170 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 TK78_RS08985 835ee3a96048531d6b50c28debba8df8 419 Gene3D G3DSA:3.40.640.10 37 282 4.8E-106 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS08985 835ee3a96048531d6b50c28debba8df8 419 Gene3D G3DSA:3.90.1150.10 283 416 8.1E-47 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS27815 e2233c30b8b58555bc98048a52218c43 218 Pfam PF00753 Metallo-beta-lactamase superfamily 32 170 1.7E-10 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS27815 e2233c30b8b58555bc98048a52218c43 218 SMART SM00849 32 197 1.5E-29 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS27815 e2233c30b8b58555bc98048a52218c43 218 SUPERFAMILY SSF56281 22 214 1.54E-44 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS27815 e2233c30b8b58555bc98048a52218c43 218 Gene3D G3DSA:3.60.15.10 19 216 6.1E-48 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS25690 c0a0c3f1a5fbb32e51b07aebe9f444fe 207 Gene3D G3DSA:3.40.50.1240 8 194 2.5E-20 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS25690 c0a0c3f1a5fbb32e51b07aebe9f444fe 207 SUPERFAMILY SSF53254 9 203 2.09E-24 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS25690 c0a0c3f1a5fbb32e51b07aebe9f444fe 207 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 9 188 1.1E-20 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS29710 0f74a53f88ed9ce6eac5980441d12369 484 Pfam PF00392 Bacterial regulatory proteins, gntR family 19 66 1.7E-13 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS29710 0f74a53f88ed9ce6eac5980441d12369 484 Gene3D G3DSA:3.40.640.10 150 362 2.2E-56 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS29710 0f74a53f88ed9ce6eac5980441d12369 484 SMART SM00345 10 67 9.5E-11 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS29710 0f74a53f88ed9ce6eac5980441d12369 484 SUPERFAMILY SSF53383 108 479 4.62E-79 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS29710 0f74a53f88ed9ce6eac5980441d12369 484 Gene3D G3DSA:1.10.10.10 19 71 1.2E-16 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS29710 0f74a53f88ed9ce6eac5980441d12369 484 Pfam PF00155 Aminotransferase class I and II 128 473 3.2E-21 T 09-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TK78_RS29710 0f74a53f88ed9ce6eac5980441d12369 484 Gene3D G3DSA:3.90.1150.10 368 474 2.1E-7 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS29710 0f74a53f88ed9ce6eac5980441d12369 484 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 27 41 3.6E-5 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS29710 0f74a53f88ed9ce6eac5980441d12369 484 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 41 57 3.6E-5 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS29710 0f74a53f88ed9ce6eac5980441d12369 484 SUPERFAMILY SSF46785 19 71 7.31E-14 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS33110 358e57717117353ee8a3b3d895ee0abc 569 Gene3D G3DSA:3.90.182.10 32 228 4.2E-17 T 09-03-2017 IPR011658 PA14 domain TK78_RS33110 358e57717117353ee8a3b3d895ee0abc 569 Pfam PF07691 PA14 domain 32 150 4.5E-9 T 09-03-2017 IPR011658 PA14 domain TK78_RS33110 358e57717117353ee8a3b3d895ee0abc 569 SUPERFAMILY SSF56988 34 199 3.66E-9 T 09-03-2017 TK78_RS32795 8c8966eae5746258878bf7f90173db57 221 Gene3D G3DSA:1.10.10.10 126 216 4.6E-29 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32795 8c8966eae5746258878bf7f90173db57 221 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 185 197 1.5E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS32795 8c8966eae5746258878bf7f90173db57 221 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 169 185 1.5E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS32795 8c8966eae5746258878bf7f90173db57 221 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 155 169 1.5E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS32795 8c8966eae5746258878bf7f90173db57 221 SUPERFAMILY SSF46894 147 215 1.6E-20 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS32795 8c8966eae5746258878bf7f90173db57 221 SMART SM00448 2 117 2.1E-30 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS32795 8c8966eae5746258878bf7f90173db57 221 Gene3D G3DSA:3.40.50.2300 2 125 2.1E-38 T 09-03-2017 TK78_RS32795 8c8966eae5746258878bf7f90173db57 221 SUPERFAMILY SSF52172 2 128 1.71E-33 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS32795 8c8966eae5746258878bf7f90173db57 221 Pfam PF00072 Response regulator receiver domain 4 117 2.5E-26 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS32795 8c8966eae5746258878bf7f90173db57 221 SMART SM00421 152 209 5.7E-23 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS32795 8c8966eae5746258878bf7f90173db57 221 Pfam PF00196 Bacterial regulatory proteins, luxR family 154 209 1.2E-16 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS07100 627d514985d57c89e0f8440aa7f2f3da 255 Pfam PF00440 Bacterial regulatory proteins, tetR family 38 82 4.3E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS07100 627d514985d57c89e0f8440aa7f2f3da 255 SUPERFAMILY SSF48498 99 250 5.89E-20 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS07100 627d514985d57c89e0f8440aa7f2f3da 255 Gene3D G3DSA:1.10.357.10 24 252 3.5E-50 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS07100 627d514985d57c89e0f8440aa7f2f3da 255 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 94 246 9.3E-13 T 09-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 TK78_RS07100 627d514985d57c89e0f8440aa7f2f3da 255 SUPERFAMILY SSF46689 27 89 2.05E-11 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS26950 c87d379a1fdef4b44b93b53ac8f387b1 644 Pfam PF00069 Protein kinase domain 19 231 8.3E-48 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS26950 c87d379a1fdef4b44b93b53ac8f387b1 644 Gene3D G3DSA:1.10.510.10 85 264 7.7E-49 T 09-03-2017 TK78_RS26950 c87d379a1fdef4b44b93b53ac8f387b1 644 SUPERFAMILY SSF54184 584 641 1.7E-5 T 09-03-2017 TK78_RS26950 c87d379a1fdef4b44b93b53ac8f387b1 644 Gene3D G3DSA:3.30.200.20 10 84 3.6E-23 T 09-03-2017 TK78_RS26950 c87d379a1fdef4b44b93b53ac8f387b1 644 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 137 149 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS26950 c87d379a1fdef4b44b93b53ac8f387b1 644 SUPERFAMILY SSF56112 15 275 4.32E-72 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS26950 c87d379a1fdef4b44b93b53ac8f387b1 644 SMART SM00740 376 443 6.2E-11 T 09-03-2017 IPR005543 PASTA domain TK78_RS26950 c87d379a1fdef4b44b93b53ac8f387b1 644 SMART SM00740 444 511 4.2E-14 T 09-03-2017 IPR005543 PASTA domain TK78_RS26950 c87d379a1fdef4b44b93b53ac8f387b1 644 SMART SM00740 579 643 3.0E-11 T 09-03-2017 IPR005543 PASTA domain TK78_RS26950 c87d379a1fdef4b44b93b53ac8f387b1 644 SMART SM00740 512 578 2.7E-13 T 09-03-2017 IPR005543 PASTA domain TK78_RS26950 c87d379a1fdef4b44b93b53ac8f387b1 644 SMART SM00220 18 281 7.3E-52 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS26950 c87d379a1fdef4b44b93b53ac8f387b1 644 Pfam PF03793 PASTA domain 585 641 7.0E-12 T 09-03-2017 IPR005543 PASTA domain TK78_RS26950 c87d379a1fdef4b44b93b53ac8f387b1 644 Pfam PF03793 PASTA domain 516 578 6.3E-14 T 09-03-2017 IPR005543 PASTA domain TK78_RS26950 c87d379a1fdef4b44b93b53ac8f387b1 644 Pfam PF03793 PASTA domain 381 442 4.6E-12 T 09-03-2017 IPR005543 PASTA domain TK78_RS26950 c87d379a1fdef4b44b93b53ac8f387b1 644 Pfam PF03793 PASTA domain 448 511 5.2E-13 T 09-03-2017 IPR005543 PASTA domain TK78_RS24415 c25bf44ff85823533e7313b761db034e 432 TIGRFAM TIGR00382 clpX: ATP-dependent Clp protease, ATP-binding subunit ClpX 9 412 1.4E-196 T 09-03-2017 IPR004487 Clp protease, ATP-binding subunit ClpX GO:0005524|GO:0006457|GO:0051082 TK78_RS24415 c25bf44ff85823533e7313b761db034e 432 Pfam PF06689 ClpX C4-type zinc finger 11 48 9.1E-21 T 09-03-2017 IPR010603 Zinc finger, ClpX C4-type GO:0008270|GO:0046983 TK78_RS24415 c25bf44ff85823533e7313b761db034e 432 SUPERFAMILY SSF57716 11 46 1.38E-11 T 09-03-2017 TK78_RS24415 c25bf44ff85823533e7313b761db034e 432 Gene3D G3DSA:3.40.50.300 295 311 1.6E-46 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24415 c25bf44ff85823533e7313b761db034e 432 Gene3D G3DSA:3.40.50.300 62 256 1.6E-46 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24415 c25bf44ff85823533e7313b761db034e 432 SMART SM01086 318 412 5.7E-29 T 09-03-2017 IPR019489 Clp ATPase, C-terminal TK78_RS24415 c25bf44ff85823533e7313b761db034e 432 Pfam PF07724 AAA domain (Cdc48 subfamily) 115 311 4.0E-51 T 09-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 TK78_RS24415 c25bf44ff85823533e7313b761db034e 432 Hamap MF_00175 ATP-dependent Clp protease ATP-binding subunit ClpX [clpX]. 2 416 52.527 T 09-03-2017 IPR004487 Clp protease, ATP-binding subunit ClpX GO:0005524|GO:0006457|GO:0051082 TK78_RS24415 c25bf44ff85823533e7313b761db034e 432 SUPERFAMILY SSF52540 58 405 5.22E-73 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24415 c25bf44ff85823533e7313b761db034e 432 SMART SM00382 114 334 5.2E-11 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS24415 c25bf44ff85823533e7313b761db034e 432 SMART SM00994 10 49 1.1E-23 T 09-03-2017 IPR010603 Zinc finger, ClpX C4-type GO:0008270|GO:0046983 TK78_RS24415 c25bf44ff85823533e7313b761db034e 432 Gene3D G3DSA:1.10.8.60 317 415 1.8E-35 T 09-03-2017 TK78_RS24415 c25bf44ff85823533e7313b761db034e 432 Pfam PF10431 C-terminal, D2-small domain, of ClpB protein 318 395 3.1E-15 T 09-03-2017 IPR019489 Clp ATPase, C-terminal TK78_RS07785 bad9b1360806a0613a4ed2806c71aee8 438 Gene3D G3DSA:1.20.1250.20 21 199 1.2E-12 T 09-03-2017 TK78_RS07785 bad9b1360806a0613a4ed2806c71aee8 438 SUPERFAMILY SSF103473 15 421 9.02E-42 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS07785 bad9b1360806a0613a4ed2806c71aee8 438 Gene3D G3DSA:1.20.1250.20 237 412 6.2E-18 T 09-03-2017 TK78_RS07785 bad9b1360806a0613a4ed2806c71aee8 438 Pfam PF05977 Transmembrane secretion effector 22 416 2.2E-17 T 09-03-2017 IPR010290 Transmembrane secretion effector TK78_RS07725 08b81c32a84b62291c111c5dbe4d12a3 510 Pfam PF05108 Type VII secretion system ESX-1, transport TM domain B 3 506 2.5E-83 T 09-03-2017 IPR007795 Type VII secretion system EccB TK78_RS07725 08b81c32a84b62291c111c5dbe4d12a3 510 TIGRFAM TIGR03919 T7SS_EccB: type VII secretion protein EccB 4 440 1.3E-53 T 09-03-2017 IPR007795 Type VII secretion system EccB TK78_RS09400 6836619194b71c016b3726988a3d59d8 428 SUPERFAMILY SSF53067 20 216 7.12E-63 T 09-03-2017 TK78_RS09400 6836619194b71c016b3726988a3d59d8 428 PIRSF PIRSF000722 17 418 4.2E-141 T 09-03-2017 IPR004372 Acetate/propionate kinase GO:0006082|GO:0016301|GO:0016774 KEGG: 00430+2.7.2.1|KEGG: 00620+2.7.2.1|KEGG: 00640+2.7.2.1|KEGG: 00680+2.7.2.1|KEGG: 00720+2.7.2.1|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497 TK78_RS09400 6836619194b71c016b3726988a3d59d8 428 ProSitePatterns PS01076 Acetate and butyrate kinases family signature 2. 223 240 - T 09-03-2017 IPR023865 Aliphatic acid kinase, short-chain, conserved site GO:0008152|GO:0016301|GO:0016310|GO:0016774 KEGG: 00430+2.7.2.1|KEGG: 00620+2.7.2.1|KEGG: 00640+2.7.2.1|KEGG: 00680+2.7.2.1|KEGG: 00720+2.7.2.1|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497 TK78_RS09400 6836619194b71c016b3726988a3d59d8 428 Gene3D G3DSA:3.30.420.40 225 414 7.4E-75 T 09-03-2017 TK78_RS09400 6836619194b71c016b3726988a3d59d8 428 Hamap MF_00020 Acetate kinase [ackA]. 1 418 169.989 T 09-03-2017 IPR004372 Acetate/propionate kinase GO:0006082|GO:0016301|GO:0016774 KEGG: 00430+2.7.2.1|KEGG: 00620+2.7.2.1|KEGG: 00640+2.7.2.1|KEGG: 00680+2.7.2.1|KEGG: 00720+2.7.2.1|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497 TK78_RS09400 6836619194b71c016b3726988a3d59d8 428 PRINTS PR00471 Acetate kinase family signature 223 244 1.9E-43 T 09-03-2017 IPR000890 Aliphatic acid kinase, short-chain GO:0005622|GO:0008152|GO:0016301|GO:0016310|GO:0016774 KEGG: 00430+2.7.2.1|KEGG: 00620+2.7.2.1|KEGG: 00640+2.7.2.1|KEGG: 00680+2.7.2.1|KEGG: 00720+2.7.2.1|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497 TK78_RS09400 6836619194b71c016b3726988a3d59d8 428 PRINTS PR00471 Acetate kinase family signature 319 332 1.9E-43 T 09-03-2017 IPR000890 Aliphatic acid kinase, short-chain GO:0005622|GO:0008152|GO:0016301|GO:0016310|GO:0016774 KEGG: 00430+2.7.2.1|KEGG: 00620+2.7.2.1|KEGG: 00640+2.7.2.1|KEGG: 00680+2.7.2.1|KEGG: 00720+2.7.2.1|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497 TK78_RS09400 6836619194b71c016b3726988a3d59d8 428 PRINTS PR00471 Acetate kinase family signature 21 32 1.9E-43 T 09-03-2017 IPR000890 Aliphatic acid kinase, short-chain GO:0005622|GO:0008152|GO:0016301|GO:0016310|GO:0016774 KEGG: 00430+2.7.2.1|KEGG: 00620+2.7.2.1|KEGG: 00640+2.7.2.1|KEGG: 00680+2.7.2.1|KEGG: 00720+2.7.2.1|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497 TK78_RS09400 6836619194b71c016b3726988a3d59d8 428 PRINTS PR00471 Acetate kinase family signature 193 206 1.9E-43 T 09-03-2017 IPR000890 Aliphatic acid kinase, short-chain GO:0005622|GO:0008152|GO:0016301|GO:0016310|GO:0016774 KEGG: 00430+2.7.2.1|KEGG: 00620+2.7.2.1|KEGG: 00640+2.7.2.1|KEGG: 00680+2.7.2.1|KEGG: 00720+2.7.2.1|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497 TK78_RS09400 6836619194b71c016b3726988a3d59d8 428 PRINTS PR00471 Acetate kinase family signature 341 357 1.9E-43 T 09-03-2017 IPR000890 Aliphatic acid kinase, short-chain GO:0005622|GO:0008152|GO:0016301|GO:0016310|GO:0016774 KEGG: 00430+2.7.2.1|KEGG: 00620+2.7.2.1|KEGG: 00640+2.7.2.1|KEGG: 00680+2.7.2.1|KEGG: 00720+2.7.2.1|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497 TK78_RS09400 6836619194b71c016b3726988a3d59d8 428 PRINTS PR00471 Acetate kinase family signature 396 408 1.9E-43 T 09-03-2017 IPR000890 Aliphatic acid kinase, short-chain GO:0005622|GO:0008152|GO:0016301|GO:0016310|GO:0016774 KEGG: 00430+2.7.2.1|KEGG: 00620+2.7.2.1|KEGG: 00640+2.7.2.1|KEGG: 00680+2.7.2.1|KEGG: 00720+2.7.2.1|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497 TK78_RS09400 6836619194b71c016b3726988a3d59d8 428 Pfam PF00871 Acetokinase family 21 409 8.5E-147 T 09-03-2017 IPR000890 Aliphatic acid kinase, short-chain GO:0005622|GO:0008152|GO:0016301|GO:0016310|GO:0016774 KEGG: 00430+2.7.2.1|KEGG: 00620+2.7.2.1|KEGG: 00640+2.7.2.1|KEGG: 00680+2.7.2.1|KEGG: 00720+2.7.2.1|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497 TK78_RS09400 6836619194b71c016b3726988a3d59d8 428 ProSitePatterns PS01075 Acetate and butyrate kinases family signature 1. 21 32 - T 09-03-2017 IPR023865 Aliphatic acid kinase, short-chain, conserved site GO:0008152|GO:0016301|GO:0016310|GO:0016774 KEGG: 00430+2.7.2.1|KEGG: 00620+2.7.2.1|KEGG: 00640+2.7.2.1|KEGG: 00680+2.7.2.1|KEGG: 00720+2.7.2.1|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497 TK78_RS09400 6836619194b71c016b3726988a3d59d8 428 SUPERFAMILY SSF53067 177 414 3.53E-81 T 09-03-2017 TK78_RS09400 6836619194b71c016b3726988a3d59d8 428 Gene3D G3DSA:3.30.420.40 20 224 6.1E-12 T 09-03-2017 TK78_RS09400 6836619194b71c016b3726988a3d59d8 428 TIGRFAM TIGR00016 ackA: acetate kinase 19 414 1.5E-141 T 09-03-2017 IPR004372 Acetate/propionate kinase GO:0006082|GO:0016301|GO:0016774 KEGG: 00430+2.7.2.1|KEGG: 00620+2.7.2.1|KEGG: 00640+2.7.2.1|KEGG: 00680+2.7.2.1|KEGG: 00720+2.7.2.1|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497 TK78_RS33505 28cefd6ff4dcb1ad5c352216c662c657 218 PRINTS PR00787 Streptomyces extracellular neutral proteinase (M7) family signature 141 165 2.7E-63 T 09-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 TK78_RS33505 28cefd6ff4dcb1ad5c352216c662c657 218 PRINTS PR00787 Streptomyces extracellular neutral proteinase (M7) family signature 84 110 2.7E-63 T 09-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 TK78_RS33505 28cefd6ff4dcb1ad5c352216c662c657 218 PRINTS PR00787 Streptomyces extracellular neutral proteinase (M7) family signature 166 190 2.7E-63 T 09-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 TK78_RS33505 28cefd6ff4dcb1ad5c352216c662c657 218 PRINTS PR00787 Streptomyces extracellular neutral proteinase (M7) family signature 116 140 2.7E-63 T 09-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 TK78_RS33505 28cefd6ff4dcb1ad5c352216c662c657 218 PRINTS PR00787 Streptomyces extracellular neutral proteinase (M7) family signature 193 207 2.7E-63 T 09-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 TK78_RS33505 28cefd6ff4dcb1ad5c352216c662c657 218 Gene3D G3DSA:3.40.390.10 79 206 4.4E-38 T 09-03-2017 IPR024079 Metallopeptidase, catalytic domain GO:0008237 TK78_RS33505 28cefd6ff4dcb1ad5c352216c662c657 218 PIRSF PIRSF016573 1 218 3.2E-109 T 09-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 TK78_RS33505 28cefd6ff4dcb1ad5c352216c662c657 218 ProDom PD016028 PROTEASE METALLOPROTEASE EXTRACELLULAR NEUTRAL SMALL METAL-BINDING ZINC HYDROLASE SNAPALYSIN ZYMOGEN 85 208 7.0E-61 T 09-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 TK78_RS33505 28cefd6ff4dcb1ad5c352216c662c657 218 SUPERFAMILY SSF55486 78 206 1.98E-30 T 09-03-2017 TK78_RS33505 28cefd6ff4dcb1ad5c352216c662c657 218 Pfam PF02031 Streptomyces extracellular neutral proteinase (M7) family 77 208 5.2E-81 T 09-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 TK78_RS04450 98f436fd19a9418a1e524935d97d9d49 534 Gene3D G3DSA:3.20.20.80 10 111 5.7E-99 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS04450 98f436fd19a9418a1e524935d97d9d49 534 Gene3D G3DSA:3.20.20.80 185 469 5.7E-99 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS04450 98f436fd19a9418a1e524935d97d9d49 534 SUPERFAMILY SSF51445 11 466 2.48E-118 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS04450 98f436fd19a9418a1e524935d97d9d49 534 Gene3D G3DSA:3.90.400.10 112 184 3.1E-27 T 09-03-2017 TK78_RS04450 98f436fd19a9418a1e524935d97d9d49 534 SMART SM00642 20 409 3.1E-116 T 09-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 TK78_RS04450 98f436fd19a9418a1e524935d97d9d49 534 Pfam PF00128 Alpha amylase, catalytic domain 35 383 5.6E-71 T 09-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 TK78_RS04450 98f436fd19a9418a1e524935d97d9d49 534 Pfam PF11941 Domain of unknown function (DUF3459) 455 532 1.6E-5 T 09-03-2017 IPR022567 Glycosyl hydrolase, C-terminal (DUF3459) TK78_RS30190 2f03d583717e465a0331f98eadb75d36 273 Pfam PF01061 ABC-2 type transporter 23 227 2.8E-23 T 09-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 TK78_RS30190 2f03d583717e465a0331f98eadb75d36 273 PIRSF PIRSF006648 21 272 1.6E-25 T 09-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 TK78_RS14775 26ee6b87012cd7bf0c80bbc424485e81 243 SUPERFAMILY SSF50891 83 211 2.2E-37 T 09-03-2017 IPR029000 Cyclophilin-like domain TK78_RS14775 26ee6b87012cd7bf0c80bbc424485e81 243 Gene3D G3DSA:2.40.100.10 83 218 4.1E-47 T 09-03-2017 IPR029000 Cyclophilin-like domain TK78_RS14775 26ee6b87012cd7bf0c80bbc424485e81 243 Pfam PF02682 Allophanate hydrolase subunit 1 2 196 3.4E-57 T 09-03-2017 IPR003833 Carboxyltransferase domain, subdomain C and D TK78_RS14775 26ee6b87012cd7bf0c80bbc424485e81 243 SMART SM00796 1 196 5.5E-64 T 09-03-2017 IPR003833 Carboxyltransferase domain, subdomain C and D TK78_RS13420 21709bc486bc21de94f8644cb4bfa99c 234 Pfam PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 66 175 1.1E-23 T 09-03-2017 IPR006137 NADH:ubiquinone oxidoreductase-like, 20kDa subunit GO:0051536|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13420 21709bc486bc21de94f8644cb4bfa99c 234 Hamap MF_01356 NAD(P)H-quinone oxidoreductase subunit K, chloroplastic [ndhK]. 11 180 40.32 T 09-03-2017 IPR006138 NADH-ubiquinone oxidoreductase, 20 Kd subunit GO:0008137|GO:0048038|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13420 21709bc486bc21de94f8644cb4bfa99c 234 TIGRFAM TIGR01957 nuoB_fam: NADH-quinone oxidoreductase, B subunit 45 181 2.2E-66 T 09-03-2017 IPR006138 NADH-ubiquinone oxidoreductase, 20 Kd subunit GO:0008137|GO:0048038|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13420 21709bc486bc21de94f8644cb4bfa99c 234 SUPERFAMILY SSF56770 45 187 1.57E-61 T 09-03-2017 TK78_RS13420 21709bc486bc21de94f8644cb4bfa99c 234 Gene3D G3DSA:3.40.50.700 49 181 2.2E-36 T 09-03-2017 IPR006137 NADH:ubiquinone oxidoreductase-like, 20kDa subunit GO:0051536|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS17630 c1d47efe1d990d0fa722d2c2b300e6cd 187 Gene3D G3DSA:3.30.70.920 88 174 2.1E-21 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS17630 c1d47efe1d990d0fa722d2c2b300e6cd 187 SUPERFAMILY SSF46785 36 95 1.94E-14 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS17630 c1d47efe1d990d0fa722d2c2b300e6cd 187 Gene3D G3DSA:1.10.10.10 35 87 3.4E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS17630 c1d47efe1d990d0fa722d2c2b300e6cd 187 Pfam PF13412 Winged helix-turn-helix DNA-binding 36 83 7.5E-15 T 09-03-2017 TK78_RS17630 c1d47efe1d990d0fa722d2c2b300e6cd 187 SUPERFAMILY SSF54909 99 173 3.62E-14 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS17630 c1d47efe1d990d0fa722d2c2b300e6cd 187 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 52 63 6.2E-10 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS17630 c1d47efe1d990d0fa722d2c2b300e6cd 187 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 36 52 6.2E-10 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS17630 c1d47efe1d990d0fa722d2c2b300e6cd 187 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 63 82 6.2E-10 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS17630 c1d47efe1d990d0fa722d2c2b300e6cd 187 Pfam PF01037 Lrp/AsnC ligand binding domain 109 173 3.5E-13 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS17630 c1d47efe1d990d0fa722d2c2b300e6cd 187 SMART SM00344 36 142 5.4E-24 T 09-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 TK78_RS10450 938d72f0e1033dfbe0dac17faf619d47 450 Gene3D G3DSA:3.65.10.10 263 446 7.3E-55 T 09-03-2017 IPR001986 Enolpyruvate transferase domain GO:0016765 TK78_RS10450 938d72f0e1033dfbe0dac17faf619d47 450 ProSitePatterns PS00885 EPSP synthase signature 2. 363 381 - T 09-03-2017 IPR023193 3-phosphoshikimate 1-carboxyvinyltransferase, conserved site KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163 TK78_RS10450 938d72f0e1033dfbe0dac17faf619d47 450 Pfam PF00275 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) 17 443 3.1E-102 T 09-03-2017 IPR001986 Enolpyruvate transferase domain GO:0016765 TK78_RS10450 938d72f0e1033dfbe0dac17faf619d47 450 Gene3D G3DSA:3.65.10.10 30 262 5.0E-60 T 09-03-2017 IPR001986 Enolpyruvate transferase domain GO:0016765 TK78_RS10450 938d72f0e1033dfbe0dac17faf619d47 450 SUPERFAMILY SSF55205 18 446 4.58E-98 T 09-03-2017 IPR013792 RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta GO:0003824 TK78_RS10450 938d72f0e1033dfbe0dac17faf619d47 450 TIGRFAM TIGR01356 aroA: 3-phosphoshikimate 1-carboxyvinyltransferase 23 447 5.4E-108 T 09-03-2017 IPR006264 3-phosphoshikimate 1-carboxyvinyltransferase GO:0003866 KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163 TK78_RS10450 938d72f0e1033dfbe0dac17faf619d47 450 PIRSF PIRSF000505 9 450 3.6E-108 T 09-03-2017 IPR006264 3-phosphoshikimate 1-carboxyvinyltransferase GO:0003866 KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163 TK78_RS10450 938d72f0e1033dfbe0dac17faf619d47 450 Hamap MF_00210 3-phosphoshikimate 1-carboxyvinyltransferase [aroA]. 18 450 27.987 T 09-03-2017 IPR006264 3-phosphoshikimate 1-carboxyvinyltransferase GO:0003866 KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163 TK78_RS10450 938d72f0e1033dfbe0dac17faf619d47 450 ProSitePatterns PS00104 EPSP synthase signature 1. 110 124 - T 09-03-2017 IPR023193 3-phosphoshikimate 1-carboxyvinyltransferase, conserved site KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163 TK78_RS29270 7aa6f27346f53f88964dc59da685062b 536 Pfam PF16901 C-terminal domain of alpha-glycerophosphate oxidase 421 534 8.0E-15 T 09-03-2017 IPR031656 Alpha-glycerophosphate oxidase, C-terminal KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 TK78_RS29270 7aa6f27346f53f88964dc59da685062b 536 SUPERFAMILY SSF51905 415 460 7.31E-35 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS29270 7aa6f27346f53f88964dc59da685062b 536 SUPERFAMILY SSF51905 33 260 7.31E-35 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS29270 7aa6f27346f53f88964dc59da685062b 536 Gene3D G3DSA:3.50.50.60 33 275 8.1E-42 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS29270 7aa6f27346f53f88964dc59da685062b 536 Pfam PF01266 FAD dependent oxidoreductase 35 389 9.9E-46 T 09-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 TK78_RS29270 7aa6f27346f53f88964dc59da685062b 536 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 34 46 1.3E-20 T 09-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 TK78_RS29270 7aa6f27346f53f88964dc59da685062b 536 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 47 57 1.3E-20 T 09-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 TK78_RS29270 7aa6f27346f53f88964dc59da685062b 536 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 378 390 1.3E-20 T 09-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 TK78_RS29270 7aa6f27346f53f88964dc59da685062b 536 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 349 355 1.3E-20 T 09-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 TK78_RS29270 7aa6f27346f53f88964dc59da685062b 536 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 109 121 1.3E-20 T 09-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 TK78_RS29270 7aa6f27346f53f88964dc59da685062b 536 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 63 75 1.3E-20 T 09-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 TK78_RS33380 ff4f70b0b78660c33b25a0b991d6f4d4 295 Gene3D G3DSA:3.20.20.70 3 293 1.1E-116 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS33380 ff4f70b0b78660c33b25a0b991d6f4d4 295 Pfam PF05853 beta-keto acid cleavage enzyme 5 291 8.2E-103 T 09-03-2017 IPR008567 3-keto-5-aminohexanoate cleavage enzyme GO:0016740|GO:0019475 KEGG: 00600+2.3.1.24 TK78_RS01190 a3da36326e6c88ddcbf83e65362abad9 253 SMART SM01134 73 234 4.2E-59 T 09-03-2017 TK78_RS01190 a3da36326e6c88ddcbf83e65362abad9 253 Pfam PF00455 DeoR C terminal sensor domain 75 232 4.5E-45 T 09-03-2017 IPR014036 DeoR C-terminal sensor domain TK78_RS01190 a3da36326e6c88ddcbf83e65362abad9 253 SUPERFAMILY SSF100950 75 236 2.88E-25 T 09-03-2017 TK78_RS01190 a3da36326e6c88ddcbf83e65362abad9 253 Gene3D G3DSA:1.10.10.10 5 66 4.2E-10 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS01190 a3da36326e6c88ddcbf83e65362abad9 253 Pfam PF08220 DeoR-like helix-turn-helix domain 6 58 2.8E-15 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS01190 a3da36326e6c88ddcbf83e65362abad9 253 Gene3D G3DSA:3.40.50.1360 78 211 1.3E-8 T 09-03-2017 TK78_RS01190 a3da36326e6c88ddcbf83e65362abad9 253 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 38 56 4.8E-9 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS01190 a3da36326e6c88ddcbf83e65362abad9 253 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 24 38 4.8E-9 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS01190 a3da36326e6c88ddcbf83e65362abad9 253 SMART SM00420 6 58 6.3E-13 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS01190 a3da36326e6c88ddcbf83e65362abad9 253 SUPERFAMILY SSF46785 3 73 3.29E-14 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS28615 4f9820e4ac1d0e6ee35f7644ab5d274b 114 SMART SM00422 1 69 4.0E-20 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS28615 4f9820e4ac1d0e6ee35f7644ab5d274b 114 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 2 13 1.5E-9 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS28615 4f9820e4ac1d0e6ee35f7644ab5d274b 114 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 13 26 1.5E-9 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS28615 4f9820e4ac1d0e6ee35f7644ab5d274b 114 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 36 56 1.5E-9 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS28615 4f9820e4ac1d0e6ee35f7644ab5d274b 114 Gene3D G3DSA:1.10.1660.10 1 112 5.7E-31 T 09-03-2017 TK78_RS28615 4f9820e4ac1d0e6ee35f7644ab5d274b 114 ProSitePatterns PS00552 MerR-type HTH domain signature. 4 26 - T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS28615 4f9820e4ac1d0e6ee35f7644ab5d274b 114 SUPERFAMILY SSF46955 1 111 1.06E-25 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS28615 4f9820e4ac1d0e6ee35f7644ab5d274b 114 Pfam PF13411 MerR HTH family regulatory protein 2 67 2.1E-18 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS24690 91715829f39b61bb212daa197d7ed0c9 624 Gene3D G3DSA:2.40.30.10 214 307 1.3E-20 T 09-03-2017 TK78_RS24690 91715829f39b61bb212daa197d7ed0c9 624 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 21 195 1.1E-18 T 09-03-2017 IPR005225 Small GTP-binding protein domain GO:0005525 TK78_RS24690 91715829f39b61bb212daa197d7ed0c9 624 Pfam PF00679 Elongation factor G C-terminus 417 502 3.4E-21 T 09-03-2017 IPR000640 Translation elongation factor EFG, V domain TK78_RS24690 91715829f39b61bb212daa197d7ed0c9 624 TIGRFAM TIGR01393 lepA: elongation factor 4 19 614 2.4E-289 T 09-03-2017 IPR006297 Elongation factor 4 GO:0005525 TK78_RS24690 91715829f39b61bb212daa197d7ed0c9 624 SUPERFAMILY SSF54980 310 389 1.4E-19 T 09-03-2017 IPR009022 Elongation factor G, III-V domain TK78_RS24690 91715829f39b61bb212daa197d7ed0c9 624 Gene3D G3DSA:3.30.70.240 419 507 7.6E-21 T 09-03-2017 IPR000640 Translation elongation factor EFG, V domain TK78_RS24690 91715829f39b61bb212daa197d7ed0c9 624 SUPERFAMILY SSF54980 417 512 1.06E-23 T 09-03-2017 IPR009022 Elongation factor G, III-V domain TK78_RS24690 91715829f39b61bb212daa197d7ed0c9 624 PRINTS PR00315 GTP-binding elongation factor signature 64 72 5.7E-13 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS24690 91715829f39b61bb212daa197d7ed0c9 624 PRINTS PR00315 GTP-binding elongation factor signature 93 103 5.7E-13 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS24690 91715829f39b61bb212daa197d7ed0c9 624 PRINTS PR00315 GTP-binding elongation factor signature 109 120 5.7E-13 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS24690 91715829f39b61bb212daa197d7ed0c9 624 PRINTS PR00315 GTP-binding elongation factor signature 145 154 5.7E-13 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS24690 91715829f39b61bb212daa197d7ed0c9 624 PRINTS PR00315 GTP-binding elongation factor signature 21 34 5.7E-13 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS24690 91715829f39b61bb212daa197d7ed0c9 624 Gene3D G3DSA:3.30.70.870 310 387 3.8E-25 T 09-03-2017 TK78_RS24690 91715829f39b61bb212daa197d7ed0c9 624 SUPERFAMILY SSF52540 13 220 3.19E-55 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24690 91715829f39b61bb212daa197d7ed0c9 624 SUPERFAMILY SSF50447 184 302 4.01E-26 T 09-03-2017 IPR009000 Translation protein, beta-barrel domain TK78_RS24690 91715829f39b61bb212daa197d7ed0c9 624 Pfam PF00009 Elongation factor Tu GTP binding domain 19 200 2.2E-50 T 09-03-2017 TK78_RS24690 91715829f39b61bb212daa197d7ed0c9 624 Pfam PF06421 GTP-binding protein LepA C-terminus 507 612 6.3E-48 T 09-03-2017 IPR013842 GTP-binding protein LepA, C-terminal TK78_RS24690 91715829f39b61bb212daa197d7ed0c9 624 Pfam PF03144 Elongation factor Tu domain 2 224 294 7.8E-8 T 09-03-2017 IPR004161 Translation elongation factor EFTu-like, domain 2 GO:0005525 TK78_RS24690 91715829f39b61bb212daa197d7ed0c9 624 Gene3D G3DSA:3.40.50.300 15 213 5.0E-56 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24690 91715829f39b61bb212daa197d7ed0c9 624 Hamap MF_00071 Elongation factor 4 [lepA]. 1 616 281.727 T 09-03-2017 IPR006297 Elongation factor 4 GO:0005525 TK78_RS24690 91715829f39b61bb212daa197d7ed0c9 624 SMART SM00838 416 500 7.2E-4 T 09-03-2017 IPR000640 Translation elongation factor EFG, V domain TK78_RS24690 91715829f39b61bb212daa197d7ed0c9 624 ProSitePatterns PS00301 Translational (tr)-type guanine nucleotide-binding (G) domain signature. 57 72 - T 09-03-2017 IPR031157 Tr-type G domain, conserved site TK78_RS03810 3dec31c6bf3fcce1f22440d5c9beaed5 227 SMART SM00448 2 112 3.6E-43 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS03810 3dec31c6bf3fcce1f22440d5c9beaed5 227 Pfam PF00486 Transcriptional regulatory protein, C terminal 148 224 4.6E-22 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS03810 3dec31c6bf3fcce1f22440d5c9beaed5 227 SUPERFAMILY SSF52172 1 187 2.85E-41 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS03810 3dec31c6bf3fcce1f22440d5c9beaed5 227 Gene3D G3DSA:3.40.50.2300 1 123 1.7E-40 T 09-03-2017 TK78_RS03810 3dec31c6bf3fcce1f22440d5c9beaed5 227 SMART SM00862 148 224 6.9E-20 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS03810 3dec31c6bf3fcce1f22440d5c9beaed5 227 Gene3D G3DSA:1.10.10.10 131 225 7.2E-28 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS03810 3dec31c6bf3fcce1f22440d5c9beaed5 227 Pfam PF00072 Response regulator receiver domain 4 112 4.2E-27 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS03895 f8a675eba78b5584ff61ef91ab135323 472 Pfam PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 20 385 9.2E-60 T 09-03-2017 IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase GO:0003824 TK78_RS03895 f8a675eba78b5584ff61ef91ab135323 472 Gene3D G3DSA:3.30.1360.110 307 371 3.5E-10 T 09-03-2017 IPR023116 Phosphonoacetate hydrolase, insert domain GO:0047400 TK78_RS03895 f8a675eba78b5584ff61ef91ab135323 472 SUPERFAMILY SSF53649 426 469 3.11E-69 T 09-03-2017 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 TK78_RS03895 f8a675eba78b5584ff61ef91ab135323 472 SUPERFAMILY SSF53649 17 371 3.11E-69 T 09-03-2017 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 TK78_RS03895 f8a675eba78b5584ff61ef91ab135323 472 Gene3D G3DSA:3.40.720.10 17 306 2.3E-50 T 09-03-2017 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 TK78_RS09175 999f11b4d7eb5ba5af4ffde9327c1a57 594 Gene3D G3DSA:3.55.50.10 112 181 2.3E-4 T 09-03-2017 TK78_RS09175 999f11b4d7eb5ba5af4ffde9327c1a57 594 Gene3D G3DSA:2.40.50.230 399 460 2.4E-13 T 09-03-2017 IPR006531 Gp5 N-terminal TK78_RS09175 999f11b4d7eb5ba5af4ffde9327c1a57 594 SUPERFAMILY SSF69279 44 189 2.13E-18 T 09-03-2017 TK78_RS09175 999f11b4d7eb5ba5af4ffde9327c1a57 594 Pfam PF05954 Phage late control gene D protein (GPD) 65 347 9.8E-12 T 09-03-2017 TK78_RS09175 999f11b4d7eb5ba5af4ffde9327c1a57 594 SUPERFAMILY SSF69255 381 461 2.88E-14 T 09-03-2017 TK78_RS27195 59fdbe088ef7f0b61523fcfb522dc32b 441 Gene3D G3DSA:3.90.1200.10 70 124 8.2E-6 T 09-03-2017 TK78_RS27195 59fdbe088ef7f0b61523fcfb522dc32b 441 SUPERFAMILY SSF56112 69 142 1.87E-6 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS27195 59fdbe088ef7f0b61523fcfb522dc32b 441 Pfam PF10009 Uncharacterized protein conserved in bacteria (DUF2252) 30 431 2.0E-118 T 09-03-2017 IPR018721 Protein of unknown function DUF2252 TK78_RS26920 40fd0862cb1331f6cd5cb6681a78463a 632 SUPERFAMILY SSF52317 440 622 5.46E-22 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS26920 40fd0862cb1331f6cd5cb6681a78463a 632 Pfam PF00425 chorismate binding enzyme 121 380 1.2E-43 T 09-03-2017 IPR015890 Chorismate-utilising enzyme, C-terminal TK78_RS26920 40fd0862cb1331f6cd5cb6681a78463a 632 Gene3D G3DSA:3.40.50.880 439 625 1.4E-27 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS26920 40fd0862cb1331f6cd5cb6681a78463a 632 PRINTS PR00096 Glutamine amidotransferase superfamily signature 484 493 4.6E-10 T 09-03-2017 TK78_RS26920 40fd0862cb1331f6cd5cb6681a78463a 632 PRINTS PR00096 Glutamine amidotransferase superfamily signature 518 529 4.6E-10 T 09-03-2017 TK78_RS26920 40fd0862cb1331f6cd5cb6681a78463a 632 PRINTS PR00096 Glutamine amidotransferase superfamily signature 604 617 4.6E-10 T 09-03-2017 TK78_RS26920 40fd0862cb1331f6cd5cb6681a78463a 632 Pfam PF00117 Glutamine amidotransferase class-I 441 622 2.6E-25 T 09-03-2017 IPR017926 Glutamine amidotransferase TK78_RS26920 40fd0862cb1331f6cd5cb6681a78463a 632 Gene3D G3DSA:3.60.120.10 98 390 7.6E-57 T 09-03-2017 IPR005801 ADC synthase GO:0009058 TK78_RS26920 40fd0862cb1331f6cd5cb6681a78463a 632 SUPERFAMILY SSF56322 71 389 2.75E-62 T 09-03-2017 IPR005801 ADC synthase GO:0009058 TK78_RS26920 40fd0862cb1331f6cd5cb6681a78463a 632 PRINTS PR00097 Anthranilate synthase component II signature 518 529 1.3E-8 T 09-03-2017 TK78_RS26920 40fd0862cb1331f6cd5cb6681a78463a 632 PRINTS PR00097 Anthranilate synthase component II signature 604 617 1.3E-8 T 09-03-2017 TK78_RS26920 40fd0862cb1331f6cd5cb6681a78463a 632 PRINTS PR00097 Anthranilate synthase component II signature 439 453 1.3E-8 T 09-03-2017 TK78_RS32235 a98000ecf0610e25dad5ff3859867014 330 SUPERFAMILY SSF55447 225 327 1.01E-25 T 09-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal TK78_RS32235 a98000ecf0610e25dad5ff3859867014 330 Gene3D G3DSA:3.30.390.50 224 325 2.6E-31 T 09-03-2017 TK78_RS32235 a98000ecf0610e25dad5ff3859867014 330 Gene3D G3DSA:3.30.43.10 1 51 3.8E-19 T 09-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 TK78_RS32235 a98000ecf0610e25dad5ff3859867014 330 SMART SM01092 226 324 2.5E-28 T 09-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal TK78_RS32235 a98000ecf0610e25dad5ff3859867014 330 Pfam PF00941 FAD binding domain in molybdopterin dehydrogenase 3 219 4.2E-51 T 09-03-2017 IPR002346 Molybdopterin dehydrogenase, FAD-binding GO:0016491|GO:0055114 TK78_RS32235 a98000ecf0610e25dad5ff3859867014 330 Pfam PF03450 CO dehydrogenase flavoprotein C-terminal domain 227 323 2.0E-17 T 09-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal TK78_RS32235 a98000ecf0610e25dad5ff3859867014 330 SUPERFAMILY SSF56176 1 219 1.25E-58 T 09-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 TK78_RS32235 a98000ecf0610e25dad5ff3859867014 330 Gene3D G3DSA:3.30.465.10 157 219 6.1E-33 T 09-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 TK78_RS32235 a98000ecf0610e25dad5ff3859867014 330 Gene3D G3DSA:3.30.465.10 56 113 6.1E-33 T 09-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 TK78_RS18240 db9937422b67f127faabb1b5a372384e 226 Gene3D G3DSA:3.40.50.880 3 221 7.3E-39 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS18240 db9937422b67f127faabb1b5a372384e 226 TIGRFAM TIGR01737 FGAM_synth_I: phosphoribosylformylglycinamidine synthase I 4 222 3.8E-81 T 09-03-2017 IPR010075 Phosphoribosylformylglycinamidine synthase subunit PurQ GO:0004642|GO:0005737|GO:0006189 KEGG: 00220+3.5.1.2|KEGG: 00230+6.3.5.3|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277 TK78_RS18240 db9937422b67f127faabb1b5a372384e 226 SUPERFAMILY SSF52317 3 221 2.15E-68 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS18240 db9937422b67f127faabb1b5a372384e 226 Hamap MF_00421 Phosphoribosylformylglycinamidine synthase subunit PurQ [purQ]. 3 221 40.256 T 09-03-2017 IPR010075 Phosphoribosylformylglycinamidine synthase subunit PurQ GO:0004642|GO:0005737|GO:0006189 KEGG: 00220+3.5.1.2|KEGG: 00230+6.3.5.3|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277 TK78_RS18240 db9937422b67f127faabb1b5a372384e 226 Pfam PF13507 CobB/CobQ-like glutamine amidotransferase domain 4 204 2.7E-33 T 09-03-2017 TK78_RS18240 db9937422b67f127faabb1b5a372384e 226 PIRSF PIRSF001586 1 226 1.2E-82 T 09-03-2017 IPR010075 Phosphoribosylformylglycinamidine synthase subunit PurQ GO:0004642|GO:0005737|GO:0006189 KEGG: 00220+3.5.1.2|KEGG: 00230+6.3.5.3|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277 TK78_RS18240 db9937422b67f127faabb1b5a372384e 226 SMART SM01211 3 223 9.7E-121 T 09-03-2017 TK78_RS26660 10ca946f32310e6ccae18ef823923504 371 TIGRFAM TIGR03160 cobT_DBIPRT: nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 14 342 6.0E-102 T 09-03-2017 IPR017846 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, prokaryotic GO:0008939|GO:0009163 KEGG: 00860+2.4.2.21|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 TK78_RS26660 10ca946f32310e6ccae18ef823923504 371 Gene3D G3DSA:3.40.50.10210 67 332 2.0E-90 T 09-03-2017 TK78_RS26660 10ca946f32310e6ccae18ef823923504 371 Gene3D G3DSA:1.10.1610.10 13 66 3.2E-17 T 09-03-2017 IPR023195 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, N-terminal GO:0008939|GO:0009236 KEGG: 00860+2.4.2.21|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 TK78_RS26660 10ca946f32310e6ccae18ef823923504 371 Hamap MF_00230 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase [cobT]. 12 351 31.655 T 09-03-2017 IPR017846 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, prokaryotic GO:0008939|GO:0009163 KEGG: 00860+2.4.2.21|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 TK78_RS26660 10ca946f32310e6ccae18ef823923504 371 SUPERFAMILY SSF52733 5 343 1.7E-92 T 09-03-2017 IPR003200 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase-like GO:0008939|GO:0009236 KEGG: 00860+2.4.2.21|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 TK78_RS26660 10ca946f32310e6ccae18ef823923504 371 Pfam PF02277 Phosphoribosyltransferase 10 341 7.4E-105 T 09-03-2017 IPR003200 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase-like GO:0008939|GO:0009236 KEGG: 00860+2.4.2.21|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 TK78_RS31625 aad7a952984044d03420621d318af0ff 220 Hamap MF_01385 Urease accessory protein UreF [ureF]. 2 220 19.023 T 09-03-2017 IPR002639 Urease accessory protein UreF GO:0006807|GO:0016151 TK78_RS31625 aad7a952984044d03420621d318af0ff 220 Pfam PF01730 UreF 34 174 4.4E-20 T 09-03-2017 IPR002639 Urease accessory protein UreF GO:0006807|GO:0016151 TK78_RS31625 aad7a952984044d03420621d318af0ff 220 PIRSF PIRSF009467 1 220 2.8E-49 T 09-03-2017 IPR002639 Urease accessory protein UreF GO:0006807|GO:0016151 TK78_RS10260 9c48ae56e3631a21658724168c9b40ed 85 Pfam PF02467 Transcription factor WhiB 3 71 1.6E-27 T 09-03-2017 IPR003482 Transcription factor WhiB TK78_RS10260 9c48ae56e3631a21658724168c9b40ed 85 Hamap MF_01479 Transcriptional regulator WhiB [whiB]. 1 76 19.15 T 09-03-2017 IPR003482 Transcription factor WhiB TK78_RS16360 5c1b1dfcd336543bc41ff261de296015 653 SMART SM00382 329 512 1.1E-18 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS16360 5c1b1dfcd336543bc41ff261de296015 653 ProSitePatterns PS00211 ABC transporters family signature. 435 449 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS16360 5c1b1dfcd336543bc41ff261de296015 653 Gene3D G3DSA:1.10.3720.10 6 260 2.9E-42 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS16360 5c1b1dfcd336543bc41ff261de296015 653 SUPERFAMILY SSF161098 13 261 2.49E-48 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS16360 5c1b1dfcd336543bc41ff261de296015 653 Pfam PF03459 TOBE domain 588 649 4.4E-13 T 09-03-2017 IPR005116 Transport-associated OB, type 1 TK78_RS16360 5c1b1dfcd336543bc41ff261de296015 653 SUPERFAMILY SSF50331 537 650 7.44E-21 T 09-03-2017 IPR008995 Molybdate/tungstate binding, C-terminal TK78_RS16360 5c1b1dfcd336543bc41ff261de296015 653 TIGRFAM TIGR01581 Mo_ABC_porter: NifC-like ABC-type porter 36 259 7.5E-70 T 09-03-2017 IPR006469 NifC-like ABC-type porter GO:0005215|GO:0006810|GO:0016020 TK78_RS16360 5c1b1dfcd336543bc41ff261de296015 653 Gene3D G3DSA:2.40.50.100 586 651 6.6E-17 T 09-03-2017 TK78_RS16360 5c1b1dfcd336543bc41ff261de296015 653 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 76 260 6.8E-16 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS16360 5c1b1dfcd336543bc41ff261de296015 653 Pfam PF00005 ABC transporter 322 462 1.7E-28 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS16360 5c1b1dfcd336543bc41ff261de296015 653 Gene3D G3DSA:3.40.50.300 320 535 2.3E-63 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS16360 5c1b1dfcd336543bc41ff261de296015 653 TIGRFAM TIGR02141 modB_ABC: molybdate ABC transporter, permease protein 59 262 2.7E-65 T 09-03-2017 IPR011867 Molybdate ABC transporter, permease protein GO:0015098|GO:0015689|GO:0016021 TK78_RS16360 5c1b1dfcd336543bc41ff261de296015 653 SUPERFAMILY SSF52540 322 538 2.54E-65 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01175 049db4a5942595c63a13ff6e8874280d 257 Gene3D G3DSA:1.10.1660.10 134 243 2.1E-17 T 09-03-2017 TK78_RS01175 049db4a5942595c63a13ff6e8874280d 257 Gene3D G3DSA:1.10.1660.10 15 115 3.0E-11 T 09-03-2017 TK78_RS01175 049db4a5942595c63a13ff6e8874280d 257 Pfam PF13411 MerR HTH family regulatory protein 135 198 1.8E-10 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS01175 049db4a5942595c63a13ff6e8874280d 257 Pfam PF00376 MerR family regulatory protein 15 49 2.1E-8 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS01175 049db4a5942595c63a13ff6e8874280d 257 SUPERFAMILY SSF46955 15 114 1.37E-8 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS01175 049db4a5942595c63a13ff6e8874280d 257 SUPERFAMILY SSF46955 133 243 4.03E-15 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS01175 049db4a5942595c63a13ff6e8874280d 257 SMART SM00422 132 201 8.8E-5 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS27325 be2abe74d4d211559dcc7f8f5adf26d6 224 TIGRFAM TIGR02234 trp_oprn_chp: membrane protein, TIGR02234 family 31 221 6.2E-53 T 09-03-2017 IPR011746 Trp biosynthesis associated, conserved hypothetical membrane protein TK78_RS27325 be2abe74d4d211559dcc7f8f5adf26d6 224 Pfam PF09534 Tryptophan-associated transmembrane protein (Trp_oprn_chp) 38 221 3.4E-54 T 09-03-2017 IPR019051 Trp biosynthesis associated, transmembrane protein, Oprn/Chp TK78_RS22980 53fac84857d10140620c429c568917bf 299 SUPERFAMILY SSF161098 27 296 5.23E-53 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS22980 53fac84857d10140620c429c568917bf 299 Gene3D G3DSA:1.10.3720.10 33 297 1.1E-50 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS22980 53fac84857d10140620c429c568917bf 299 TIGRFAM TIGR03226 PhnU: 2-aminoethylphosphonate ABC transporter, permease protein 22 298 1.6E-97 T 09-03-2017 IPR017636 2-aminoethylphosphonate ABC transporter system, permease protein phnU GO:0016020|GO:0033223 TK78_RS22980 53fac84857d10140620c429c568917bf 299 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 101 296 5.0E-19 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS09820 4c93ac60300f67c73bb14edb139e184b 434 Hamap MF_00051 Serine hydroxymethyltransferase [glyA]. 20 430 47.638 T 09-03-2017 IPR001085 Serine hydroxymethyltransferase GO:0016740 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 TK78_RS09820 4c93ac60300f67c73bb14edb139e184b 434 PIRSF PIRSF000412 4 433 1.6E-157 T 09-03-2017 IPR001085 Serine hydroxymethyltransferase GO:0016740 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 TK78_RS09820 4c93ac60300f67c73bb14edb139e184b 434 Pfam PF00464 Serine hydroxymethyltransferase 22 397 3.3E-146 T 09-03-2017 IPR001085 Serine hydroxymethyltransferase GO:0016740 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 TK78_RS09820 4c93ac60300f67c73bb14edb139e184b 434 Gene3D G3DSA:3.40.640.10 50 296 9.8E-92 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS09820 4c93ac60300f67c73bb14edb139e184b 434 Gene3D G3DSA:3.90.1150.10 297 430 6.3E-48 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS09820 4c93ac60300f67c73bb14edb139e184b 434 ProSitePatterns PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 235 251 - T 09-03-2017 IPR019798 Serine hydroxymethyltransferase, pyridoxal phosphate binding site GO:0004372|GO:0006544|GO:0006563|GO:0030170 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 TK78_RS09820 4c93ac60300f67c73bb14edb139e184b 434 SUPERFAMILY SSF53383 20 430 4.31E-158 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS33725 87a684ce80e5432bb31fa3d4bf9877c7 433 SUPERFAMILY SSF54826 10 143 4.71E-50 T 09-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS33725 87a684ce80e5432bb31fa3d4bf9877c7 433 Pfam PF03952 Enolase, N-terminal domain 11 141 4.6E-53 T 09-03-2017 IPR020811 Enolase, N-terminal KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS33725 87a684ce80e5432bb31fa3d4bf9877c7 433 Gene3D G3DSA:3.20.20.120 136 427 3.0E-123 T 09-03-2017 IPR029065 Enolase C-terminal domain-like TK78_RS33725 87a684ce80e5432bb31fa3d4bf9877c7 433 PIRSF PIRSF001400 7 431 2.7E-176 T 09-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS33725 87a684ce80e5432bb31fa3d4bf9877c7 433 ProSitePatterns PS00164 Enolase signature. 341 354 - T 09-03-2017 IPR020809 Enolase, conserved site KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS33725 87a684ce80e5432bb31fa3d4bf9877c7 433 SMART SM01192 146 432 1.7E-198 T 09-03-2017 IPR020810 Enolase, C-terminal TIM barrel domain KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS33725 87a684ce80e5432bb31fa3d4bf9877c7 433 TIGRFAM TIGR01060 eno: phosphopyruvate hydratase 11 428 8.8E-190 T 09-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS33725 87a684ce80e5432bb31fa3d4bf9877c7 433 PRINTS PR00148 Enolase signature 114 130 1.7E-43 T 09-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS33725 87a684ce80e5432bb31fa3d4bf9877c7 433 PRINTS PR00148 Enolase signature 318 329 1.7E-43 T 09-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS33725 87a684ce80e5432bb31fa3d4bf9877c7 433 PRINTS PR00148 Enolase signature 341 355 1.7E-43 T 09-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS33725 87a684ce80e5432bb31fa3d4bf9877c7 433 PRINTS PR00148 Enolase signature 370 387 1.7E-43 T 09-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS33725 87a684ce80e5432bb31fa3d4bf9877c7 433 PRINTS PR00148 Enolase signature 44 58 1.7E-43 T 09-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS33725 87a684ce80e5432bb31fa3d4bf9877c7 433 PRINTS PR00148 Enolase signature 168 181 1.7E-43 T 09-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS33725 87a684ce80e5432bb31fa3d4bf9877c7 433 Gene3D G3DSA:3.30.390.10 11 132 2.9E-49 T 09-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS33725 87a684ce80e5432bb31fa3d4bf9877c7 433 Pfam PF00113 Enolase, C-terminal TIM barrel domain 148 427 8.7E-116 T 09-03-2017 IPR020810 Enolase, C-terminal TIM barrel domain KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS33725 87a684ce80e5432bb31fa3d4bf9877c7 433 SMART SM01193 11 141 2.0E-81 T 09-03-2017 IPR020811 Enolase, N-terminal KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS33725 87a684ce80e5432bb31fa3d4bf9877c7 433 Hamap MF_00318 Enolase [eno]. 9 418 43.299 T 09-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS33725 87a684ce80e5432bb31fa3d4bf9877c7 433 SUPERFAMILY SSF51604 146 427 8.43E-119 T 09-03-2017 IPR029065 Enolase C-terminal domain-like TK78_RS28210 84f85587821c4399791753950fe1e856 541 Gene3D G3DSA:3.30.420.180 15 145 1.6E-27 T 09-03-2017 IPR002750 CobE/GbiG C-terminal domain GO:0009236 TK78_RS28210 84f85587821c4399791753950fe1e856 541 SUPERFAMILY SSF159664 15 145 1.44E-28 T 09-03-2017 IPR002750 CobE/GbiG C-terminal domain GO:0009236 TK78_RS28210 84f85587821c4399791753950fe1e856 541 ProSitePatterns PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 387 400 - T 09-03-2017 IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding site GO:0003824|GO:0009058|GO:0030170 TK78_RS28210 84f85587821c4399791753950fe1e856 541 Pfam PF01890 Cobalamin synthesis G C-terminus 17 144 1.7E-30 T 09-03-2017 IPR002750 CobE/GbiG C-terminal domain GO:0009236 TK78_RS28210 84f85587821c4399791753950fe1e856 541 Pfam PF00155 Aminotransferase class I and II 208 528 1.1E-30 T 09-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TK78_RS28210 84f85587821c4399791753950fe1e856 541 Gene3D G3DSA:3.40.640.10 221 429 2.1E-50 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS28210 84f85587821c4399791753950fe1e856 541 Gene3D G3DSA:3.90.1150.10 430 532 1.6E-16 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS28210 84f85587821c4399791753950fe1e856 541 SUPERFAMILY SSF53383 199 531 1.68E-60 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS30900 0f5baa0342b40c220549e00538992d08 205 SUPERFAMILY SSF46894 133 201 9.52E-18 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS30900 0f5baa0342b40c220549e00538992d08 205 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 145 159 1.3E-9 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS30900 0f5baa0342b40c220549e00538992d08 205 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 175 187 1.3E-9 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS30900 0f5baa0342b40c220549e00538992d08 205 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 159 175 1.3E-9 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS30900 0f5baa0342b40c220549e00538992d08 205 SUPERFAMILY SSF52172 1 134 2.42E-35 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS30900 0f5baa0342b40c220549e00538992d08 205 SMART SM00421 142 199 9.8E-21 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS30900 0f5baa0342b40c220549e00538992d08 205 Pfam PF00196 Bacterial regulatory proteins, luxR family 144 196 2.2E-16 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS30900 0f5baa0342b40c220549e00538992d08 205 SMART SM00448 2 115 1.2E-30 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS30900 0f5baa0342b40c220549e00538992d08 205 Gene3D G3DSA:3.40.50.2300 1 145 3.6E-41 T 09-03-2017 TK78_RS30900 0f5baa0342b40c220549e00538992d08 205 Gene3D G3DSA:1.10.10.10 146 201 1.5E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS30900 0f5baa0342b40c220549e00538992d08 205 Pfam PF00072 Response regulator receiver domain 5 115 5.6E-27 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS32420 2e03373133c1afb9897225a9bae49e27 254 SMART SM00345 47 105 4.8E-14 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS32420 2e03373133c1afb9897225a9bae49e27 254 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 79 95 2.0E-5 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS32420 2e03373133c1afb9897225a9bae49e27 254 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 65 79 2.0E-5 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS32420 2e03373133c1afb9897225a9bae49e27 254 SMART SM00895 115 241 1.5E-12 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS32420 2e03373133c1afb9897225a9bae49e27 254 SUPERFAMILY SSF46785 39 109 1.59E-16 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32420 2e03373133c1afb9897225a9bae49e27 254 Gene3D G3DSA:1.10.10.10 35 106 1.1E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32420 2e03373133c1afb9897225a9bae49e27 254 Pfam PF00392 Bacterial regulatory proteins, gntR family 45 105 1.8E-14 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS32420 2e03373133c1afb9897225a9bae49e27 254 Gene3D G3DSA:1.20.120.530 110 248 3.6E-22 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS32420 2e03373133c1afb9897225a9bae49e27 254 SUPERFAMILY SSF48008 112 246 2.17E-19 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS32420 2e03373133c1afb9897225a9bae49e27 254 Pfam PF07729 FCD domain 116 240 2.5E-15 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS31055 601b6e892cb8b3d522ce25ea50775e3f 245 Pfam PF00797 N-acetyltransferase 20 244 1.4E-41 T 09-03-2017 IPR001447 Arylamine N-acetyltransferase GO:0008152|GO:0016407 KEGG: 00232+2.3.1.5|KEGG: 00633+2.3.1.5|KEGG: 00983+2.3.1.5|Reactome: R-HSA-156582 TK78_RS31055 601b6e892cb8b3d522ce25ea50775e3f 245 PRINTS PR01543 Arylamine N-acetyltransferase signature 68 90 6.1E-7 T 09-03-2017 IPR001447 Arylamine N-acetyltransferase GO:0008152|GO:0016407 KEGG: 00232+2.3.1.5|KEGG: 00633+2.3.1.5|KEGG: 00983+2.3.1.5|Reactome: R-HSA-156582 TK78_RS31055 601b6e892cb8b3d522ce25ea50775e3f 245 PRINTS PR01543 Arylamine N-acetyltransferase signature 44 67 6.1E-7 T 09-03-2017 IPR001447 Arylamine N-acetyltransferase GO:0008152|GO:0016407 KEGG: 00232+2.3.1.5|KEGG: 00633+2.3.1.5|KEGG: 00983+2.3.1.5|Reactome: R-HSA-156582 TK78_RS31055 601b6e892cb8b3d522ce25ea50775e3f 245 PRINTS PR01543 Arylamine N-acetyltransferase signature 100 125 6.1E-7 T 09-03-2017 IPR001447 Arylamine N-acetyltransferase GO:0008152|GO:0016407 KEGG: 00232+2.3.1.5|KEGG: 00633+2.3.1.5|KEGG: 00983+2.3.1.5|Reactome: R-HSA-156582 TK78_RS31055 601b6e892cb8b3d522ce25ea50775e3f 245 Gene3D G3DSA:3.30.2140.10 3 167 6.9E-28 T 09-03-2017 TK78_RS31055 601b6e892cb8b3d522ce25ea50775e3f 245 SUPERFAMILY SSF54001 2 245 2.45E-57 T 09-03-2017 TK78_RS19635 7bb86853d847cae6706c07a3b955d15a 684 Gene3D G3DSA:3.40.50.300 165 349 6.7E-62 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS19635 7bb86853d847cae6706c07a3b955d15a 684 TIGRFAM TIGR01241 FtsH_fam: ATP-dependent metallopeptidase HflB 122 612 7.0E-231 T 09-03-2017 IPR005936 Peptidase, FtsH GO:0004222|GO:0016020 TK78_RS19635 7bb86853d847cae6706c07a3b955d15a 684 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 209 341 5.6E-45 T 09-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 TK78_RS19635 7bb86853d847cae6706c07a3b955d15a 684 ProSitePatterns PS00674 AAA-protein family signature. 312 330 - T 09-03-2017 IPR003960 ATPase, AAA-type, conserved site GO:0005524 TK78_RS19635 7bb86853d847cae6706c07a3b955d15a 684 Gene3D G3DSA:1.10.8.60 350 416 4.2E-23 T 09-03-2017 TK78_RS19635 7bb86853d847cae6706c07a3b955d15a 684 SUPERFAMILY SSF140990 423 618 2.75E-73 T 09-03-2017 TK78_RS19635 7bb86853d847cae6706c07a3b955d15a 684 SUPERFAMILY SSF52540 163 413 4.6E-70 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS19635 7bb86853d847cae6706c07a3b955d15a 684 SMART SM00382 205 344 6.5E-25 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS19635 7bb86853d847cae6706c07a3b955d15a 684 Hamap MF_01458 ATP-dependent zinc metalloprotease FtsH [ftsH]. 5 621 37.168 T 09-03-2017 IPR005936 Peptidase, FtsH GO:0004222|GO:0016020 TK78_RS19635 7bb86853d847cae6706c07a3b955d15a 684 Pfam PF01434 Peptidase family M41 404 611 8.7E-80 T 09-03-2017 IPR000642 Peptidase M41 GO:0004222|GO:0005524|GO:0006508 TK78_RS12785 64caf4a9140634bae073e58a9cdf6ccd 541 SUPERFAMILY SSF48592 6 133 1.42E-71 T 09-03-2017 TK78_RS12785 64caf4a9140634bae073e58a9cdf6ccd 541 SUPERFAMILY SSF48592 406 521 1.42E-71 T 09-03-2017 TK78_RS12785 64caf4a9140634bae073e58a9cdf6ccd 541 Gene3D G3DSA:1.10.560.10 6 186 5.8E-43 T 09-03-2017 IPR027413 GroEL-like equatorial domain TK78_RS12785 64caf4a9140634bae073e58a9cdf6ccd 541 PRINTS PR00298 60kDa chaperonin signature 350 375 6.1E-71 T 09-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 TK78_RS12785 64caf4a9140634bae073e58a9cdf6ccd 541 PRINTS PR00298 60kDa chaperonin signature 26 52 6.1E-71 T 09-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 TK78_RS12785 64caf4a9140634bae073e58a9cdf6ccd 541 PRINTS PR00298 60kDa chaperonin signature 82 109 6.1E-71 T 09-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 TK78_RS12785 64caf4a9140634bae073e58a9cdf6ccd 541 PRINTS PR00298 60kDa chaperonin signature 268 291 6.1E-71 T 09-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 TK78_RS12785 64caf4a9140634bae073e58a9cdf6ccd 541 PRINTS PR00298 60kDa chaperonin signature 398 419 6.1E-71 T 09-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 TK78_RS12785 64caf4a9140634bae073e58a9cdf6ccd 541 Gene3D G3DSA:3.50.7.10 187 368 3.6E-94 T 09-03-2017 IPR027409 GroEL-like apical domain TK78_RS12785 64caf4a9140634bae073e58a9cdf6ccd 541 ProSitePatterns PS00296 Chaperonins cpn60 signature. 405 416 - T 09-03-2017 IPR018370 Chaperonin Cpn60, conserved site GO:0005524|GO:0005737|GO:0006457 Reactome: R-HSA-1268020 TK78_RS12785 64caf4a9140634bae073e58a9cdf6ccd 541 Gene3D G3DSA:1.10.560.10 369 518 8.7E-37 T 09-03-2017 IPR027413 GroEL-like equatorial domain TK78_RS12785 64caf4a9140634bae073e58a9cdf6ccd 541 Pfam PF00118 TCP-1/cpn60 chaperonin family 22 524 4.3E-92 T 09-03-2017 IPR002423 Chaperonin Cpn60/TCP-1 family GO:0005524 TK78_RS12785 64caf4a9140634bae073e58a9cdf6ccd 541 TIGRFAM TIGR02348 GroEL: chaperonin GroL 2 526 1.6E-243 T 09-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 TK78_RS12785 64caf4a9140634bae073e58a9cdf6ccd 541 SUPERFAMILY SSF52029 185 376 3.66E-79 T 09-03-2017 IPR027409 GroEL-like apical domain TK78_RS12785 64caf4a9140634bae073e58a9cdf6ccd 541 SUPERFAMILY SSF54849 136 203 3.66E-24 T 09-03-2017 TK78_RS12785 64caf4a9140634bae073e58a9cdf6ccd 541 Hamap MF_00600 60 kDa chaperonin [groL]. 1 537 41.487 T 09-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 TK78_RS27250 fa8adb5a2ed37d1865254b952dca8fda 440 Pfam PF00815 Histidinol dehydrogenase 23 433 2.9E-154 T 09-03-2017 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 TK78_RS27250 fa8adb5a2ed37d1865254b952dca8fda 440 PIRSF PIRSF000099 5 436 3.3E-158 T 09-03-2017 IPR022695 Histidinol dehydrogenase, monofunctional GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 TK78_RS27250 fa8adb5a2ed37d1865254b952dca8fda 440 SUPERFAMILY SSF53720 16 435 2.55E-70 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS27250 fa8adb5a2ed37d1865254b952dca8fda 440 Hamap MF_01024 Histidinol dehydrogenase [hisD]. 5 433 38.244 T 09-03-2017 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 TK78_RS27250 fa8adb5a2ed37d1865254b952dca8fda 440 TIGRFAM TIGR00069 hisD: histidinol dehydrogenase 36 432 1.4E-139 T 09-03-2017 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 TK78_RS27250 fa8adb5a2ed37d1865254b952dca8fda 440 Gene3D G3DSA:3.40.50.1980 30 243 3.3E-77 T 09-03-2017 TK78_RS27250 fa8adb5a2ed37d1865254b952dca8fda 440 PRINTS PR00083 Histidinol dehydrogenase signature 137 163 4.1E-81 T 09-03-2017 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 TK78_RS27250 fa8adb5a2ed37d1865254b952dca8fda 440 PRINTS PR00083 Histidinol dehydrogenase signature 367 385 4.1E-81 T 09-03-2017 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 TK78_RS27250 fa8adb5a2ed37d1865254b952dca8fda 440 PRINTS PR00083 Histidinol dehydrogenase signature 255 274 4.1E-81 T 09-03-2017 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 TK78_RS27250 fa8adb5a2ed37d1865254b952dca8fda 440 PRINTS PR00083 Histidinol dehydrogenase signature 326 351 4.1E-81 T 09-03-2017 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 TK78_RS27250 fa8adb5a2ed37d1865254b952dca8fda 440 PRINTS PR00083 Histidinol dehydrogenase signature 233 254 4.1E-81 T 09-03-2017 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 TK78_RS27250 fa8adb5a2ed37d1865254b952dca8fda 440 PRINTS PR00083 Histidinol dehydrogenase signature 174 200 4.1E-81 T 09-03-2017 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 TK78_RS27250 fa8adb5a2ed37d1865254b952dca8fda 440 PRINTS PR00083 Histidinol dehydrogenase signature 204 229 4.1E-81 T 09-03-2017 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 TK78_RS27250 fa8adb5a2ed37d1865254b952dca8fda 440 PRINTS PR00083 Histidinol dehydrogenase signature 36 60 4.1E-81 T 09-03-2017 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 TK78_RS27250 fa8adb5a2ed37d1865254b952dca8fda 440 ProSitePatterns PS00611 Histidinol dehydrogenase signature. 233 265 - T 09-03-2017 IPR001692 Histidinol dehydrogenase, conserved site GO:0000105|GO:0004399|GO:0055114 KEGG: 00340+1.1.1.23 TK78_RS24140 1b5c5cc95b1338436d97c548fedf3347 421 Pfam PF02056 Family 4 glycosyl hydrolase 2 179 1.1E-46 T 09-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 TK78_RS24140 1b5c5cc95b1338436d97c548fedf3347 421 SUPERFAMILY SSF56327 163 418 3.71E-61 T 09-03-2017 IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal GO:0003824|GO:0005975|GO:0016616|GO:0055114 TK78_RS24140 1b5c5cc95b1338436d97c548fedf3347 421 Gene3D G3DSA:3.90.110.10 162 418 2.6E-84 T 09-03-2017 IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal GO:0003824|GO:0005975|GO:0016616|GO:0055114 TK78_RS24140 1b5c5cc95b1338436d97c548fedf3347 421 SUPERFAMILY SSF51735 1 156 4.49E-44 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS24140 1b5c5cc95b1338436d97c548fedf3347 421 Pfam PF11975 Family 4 glycosyl hydrolase C-terminal domain 190 397 5.4E-40 T 09-03-2017 IPR022616 Glycosyl hydrolase, family 4, C-terminal GO:0004553 TK78_RS24140 1b5c5cc95b1338436d97c548fedf3347 421 PRINTS PR00732 Glycosyl hydrolase family 4 signature 92 105 2.9E-35 T 09-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 TK78_RS24140 1b5c5cc95b1338436d97c548fedf3347 421 PRINTS PR00732 Glycosyl hydrolase family 4 signature 71 87 2.9E-35 T 09-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 TK78_RS24140 1b5c5cc95b1338436d97c548fedf3347 421 PRINTS PR00732 Glycosyl hydrolase family 4 signature 135 152 2.9E-35 T 09-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 TK78_RS24140 1b5c5cc95b1338436d97c548fedf3347 421 PRINTS PR00732 Glycosyl hydrolase family 4 signature 185 197 2.9E-35 T 09-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 TK78_RS24140 1b5c5cc95b1338436d97c548fedf3347 421 PRINTS PR00732 Glycosyl hydrolase family 4 signature 2 17 2.9E-35 T 09-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 TK78_RS24140 1b5c5cc95b1338436d97c548fedf3347 421 PRINTS PR00732 Glycosyl hydrolase family 4 signature 106 126 2.9E-35 T 09-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 TK78_RS24140 1b5c5cc95b1338436d97c548fedf3347 421 Gene3D G3DSA:3.40.50.720 1 159 1.1E-55 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS18925 3eef79b509aa1031b4077ff159ddbd88 224 TIGRFAM TIGR01549 HAD-SF-IA-v1: HAD hydrolase, family IA, variant 1 109 197 9.0E-6 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS18925 3eef79b509aa1031b4077ff159ddbd88 224 SUPERFAMILY SSF56784 20 213 9.06E-30 T 09-03-2017 IPR023214 HAD-like domain TK78_RS18925 3eef79b509aa1031b4077ff159ddbd88 224 Pfam PF13419 Haloacid dehalogenase-like hydrolase 110 201 1.6E-9 T 09-03-2017 IPR023214 HAD-like domain TK78_RS18925 3eef79b509aa1031b4077ff159ddbd88 224 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 106 202 7.4E-16 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS18925 3eef79b509aa1031b4077ff159ddbd88 224 Gene3D G3DSA:3.40.50.1000 20 210 1.9E-32 T 09-03-2017 IPR023214 HAD-like domain TK78_RS18925 3eef79b509aa1031b4077ff159ddbd88 224 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 192 205 3.0E-6 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS18925 3eef79b509aa1031b4077ff159ddbd88 224 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 147 163 3.0E-6 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS18925 3eef79b509aa1031b4077ff159ddbd88 224 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 165 185 3.0E-6 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS08865 05a53a6a56314c88ea2bac99553570d8 743 SUPERFAMILY SSF52113 640 711 6.73E-18 T 09-03-2017 IPR001357 BRCT domain TK78_RS08865 05a53a6a56314c88ea2bac99553570d8 743 Pfam PF03120 NAD-dependent DNA ligase OB-fold domain 333 409 3.2E-28 T 09-03-2017 IPR004150 NAD-dependent DNA ligase, OB-fold GO:0003911|GO:0006260|GO:0006281 TK78_RS08865 05a53a6a56314c88ea2bac99553570d8 743 SMART SM00532 16 460 4.6E-260 T 09-03-2017 IPR013840 NAD-dependent DNA ligase, N-terminal GO:0003911 TK78_RS08865 05a53a6a56314c88ea2bac99553570d8 743 Gene3D G3DSA:3.40.50.10190 641 717 3.9E-24 T 09-03-2017 IPR001357 BRCT domain TK78_RS08865 05a53a6a56314c88ea2bac99553570d8 743 Gene3D G3DSA:1.10.150.20 447 503 5.4E-8 T 09-03-2017 TK78_RS08865 05a53a6a56314c88ea2bac99553570d8 743 SUPERFAMILY SSF47781 414 507 1.85E-43 T 09-03-2017 IPR010994 RuvA domain 2-like TK78_RS08865 05a53a6a56314c88ea2bac99553570d8 743 SUPERFAMILY SSF47781 538 630 1.85E-43 T 09-03-2017 IPR010994 RuvA domain 2-like TK78_RS08865 05a53a6a56314c88ea2bac99553570d8 743 PIRSF PIRSF001604 8 719 3.5E-237 T 09-03-2017 IPR001679 NAD-dependent DNA ligase GO:0003911|GO:0006260|GO:0006281 TK78_RS08865 05a53a6a56314c88ea2bac99553570d8 743 TIGRFAM TIGR00575 dnlj: DNA ligase, NAD-dependent 24 502 6.5E-178 T 09-03-2017 IPR001679 NAD-dependent DNA ligase GO:0003911|GO:0006260|GO:0006281 TK78_RS08865 05a53a6a56314c88ea2bac99553570d8 743 ProSitePatterns PS01055 NAD-dependent DNA ligase signature 1. 127 156 - T 09-03-2017 IPR018239 NAD-dependent DNA ligase, active site TK78_RS08865 05a53a6a56314c88ea2bac99553570d8 743 Hamap MF_01588 DNA ligase [ligA]. 15 715 51.073 T 09-03-2017 IPR001679 NAD-dependent DNA ligase GO:0003911|GO:0006260|GO:0006281 TK78_RS08865 05a53a6a56314c88ea2bac99553570d8 743 SUPERFAMILY SSF50249 329 410 6.51E-24 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS08865 05a53a6a56314c88ea2bac99553570d8 743 Gene3D G3DSA:3.30.470.30 131 263 1.1E-50 T 09-03-2017 TK78_RS08865 05a53a6a56314c88ea2bac99553570d8 743 Pfam PF01653 NAD-dependent DNA ligase adenylation domain 17 329 1.0E-123 T 09-03-2017 IPR013839 NAD-dependent DNA ligase, adenylation GO:0003911 TK78_RS08865 05a53a6a56314c88ea2bac99553570d8 743 SMART SM00292 641 718 1.5E-10 T 09-03-2017 IPR001357 BRCT domain TK78_RS08865 05a53a6a56314c88ea2bac99553570d8 743 Gene3D G3DSA:1.10.287.610 9 78 9.7E-28 T 09-03-2017 TK78_RS08865 05a53a6a56314c88ea2bac99553570d8 743 SUPERFAMILY SSF56091 15 329 2.88E-114 T 09-03-2017 TK78_RS08865 05a53a6a56314c88ea2bac99553570d8 743 ProSitePatterns PS01056 NAD-dependent DNA ligase signature 2. 342 357 - T 09-03-2017 IPR033136 NAD-dependent DNA ligase, conserved site TK78_RS08865 05a53a6a56314c88ea2bac99553570d8 743 Pfam PF00533 BRCA1 C Terminus (BRCT) domain 641 710 4.6E-13 T 09-03-2017 IPR001357 BRCT domain TK78_RS08865 05a53a6a56314c88ea2bac99553570d8 743 Pfam PF03119 NAD-dependent DNA ligase C4 zinc finger domain 418 446 2.6E-8 T 09-03-2017 IPR004149 Zinc-finger, NAD-dependent DNA ligase C4-type GO:0003911|GO:0006260|GO:0006281 TK78_RS08865 05a53a6a56314c88ea2bac99553570d8 743 Gene3D G3DSA:1.10.150.20 551 631 9.4E-27 T 09-03-2017 TK78_RS08865 05a53a6a56314c88ea2bac99553570d8 743 Pfam PF12826 Helix-hairpin-helix motif 557 620 5.1E-21 T 09-03-2017 TK78_RS08865 05a53a6a56314c88ea2bac99553570d8 743 Gene3D G3DSA:2.40.50.140 331 401 2.8E-26 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS30595 6fd39192dc74cedd2c26c02634145497 499 Gene3D G3DSA:3.90.1150.10 349 480 3.6E-17 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS30595 6fd39192dc74cedd2c26c02634145497 499 SUPERFAMILY SSF53383 119 480 9.18E-72 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS30595 6fd39192dc74cedd2c26c02634145497 499 Pfam PF00155 Aminotransferase class I and II 159 473 3.2E-29 T 09-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TK78_RS30595 6fd39192dc74cedd2c26c02634145497 499 Pfam PF00392 Bacterial regulatory proteins, gntR family 35 94 2.8E-11 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS30595 6fd39192dc74cedd2c26c02634145497 499 SUPERFAMILY SSF46785 31 101 1.45E-14 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS30595 6fd39192dc74cedd2c26c02634145497 499 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 71 87 1.3E-7 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS30595 6fd39192dc74cedd2c26c02634145497 499 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 57 71 1.3E-7 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS30595 6fd39192dc74cedd2c26c02634145497 499 Gene3D G3DSA:3.40.640.10 134 348 2.4E-41 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS30595 6fd39192dc74cedd2c26c02634145497 499 Gene3D G3DSA:1.10.10.10 31 96 2.4E-18 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS30595 6fd39192dc74cedd2c26c02634145497 499 SMART SM00345 38 97 3.1E-6 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS25350 8a339840971c13aa1b7d968849c27f1c 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 208 228 1.4E-33 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS25350 8a339840971c13aa1b7d968849c27f1c 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 155 174 1.4E-33 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS25350 8a339840971c13aa1b7d968849c27f1c 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 176 193 1.4E-33 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS25350 8a339840971c13aa1b7d968849c27f1c 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 83 94 1.4E-33 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS25350 8a339840971c13aa1b7d968849c27f1c 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 128 144 1.4E-33 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS25350 8a339840971c13aa1b7d968849c27f1c 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 1.4E-33 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS25350 8a339840971c13aa1b7d968849c27f1c 246 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 134 142 2.3E-12 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS25350 8a339840971c13aa1b7d968849c27f1c 246 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 155 174 2.3E-12 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS25350 8a339840971c13aa1b7d968849c27f1c 246 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 83 94 2.3E-12 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS25350 8a339840971c13aa1b7d968849c27f1c 246 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 7 192 0.0095 T 09-03-2017 TK78_RS25350 8a339840971c13aa1b7d968849c27f1c 246 Gene3D G3DSA:3.40.50.720 2 246 9.1E-77 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS25350 8a339840971c13aa1b7d968849c27f1c 246 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 15 245 1.2E-57 T 09-03-2017 TK78_RS25350 8a339840971c13aa1b7d968849c27f1c 246 SUPERFAMILY SSF51735 2 246 5.68E-75 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS10985 0e87939629f18cc41b1bdac0579a34d2 318 SUPERFAMILY SSF161098 111 301 7.46E-23 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS10985 0e87939629f18cc41b1bdac0579a34d2 318 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C 35 88 2.6E-11 T 09-03-2017 IPR025966 Oligopeptide transport permease C-like, N-terminal domain TK78_RS10985 0e87939629f18cc41b1bdac0579a34d2 318 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 134 318 5.1E-29 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS10985 0e87939629f18cc41b1bdac0579a34d2 318 Gene3D G3DSA:1.10.3720.10 111 315 1.5E-25 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS27255 ae596c64876a6407c42ce0779eaa0ea9 376 Gene3D G3DSA:3.90.1150.10 278 372 7.4E-17 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS27255 ae596c64876a6407c42ce0779eaa0ea9 376 Pfam PF00155 Aminotransferase class I and II 36 367 8.6E-66 T 09-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TK78_RS27255 ae596c64876a6407c42ce0779eaa0ea9 376 ProSitePatterns PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 234 243 - T 09-03-2017 IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site GO:0008152|GO:0016740 TK78_RS27255 ae596c64876a6407c42ce0779eaa0ea9 376 Gene3D G3DSA:3.40.640.10 54 277 6.6E-64 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS27255 ae596c64876a6407c42ce0779eaa0ea9 376 SUPERFAMILY SSF53383 35 370 8.97E-76 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS27255 ae596c64876a6407c42ce0779eaa0ea9 376 TIGRFAM TIGR01141 hisC: histidinol-phosphate transaminase 18 369 1.7E-95 T 09-03-2017 IPR005861 Histidinol-phosphate aminotransferase family GO:0000105|GO:0004400 KEGG: 00340+2.6.1.9|KEGG: 00350+2.6.1.9|KEGG: 00360+2.6.1.9|KEGG: 00400+2.6.1.9|KEGG: 00401+2.6.1.9|KEGG: 00960+2.6.1.9 TK78_RS27255 ae596c64876a6407c42ce0779eaa0ea9 376 Hamap MF_01023 Histidinol-phosphate aminotransferase [hisC]. 16 371 53.72 T 09-03-2017 IPR005861 Histidinol-phosphate aminotransferase family GO:0000105|GO:0004400 KEGG: 00340+2.6.1.9|KEGG: 00350+2.6.1.9|KEGG: 00360+2.6.1.9|KEGG: 00400+2.6.1.9|KEGG: 00401+2.6.1.9|KEGG: 00960+2.6.1.9 TK78_RS10005 e38676914547574e43097c4e5eb081ee 1271 Pfam PF00676 Dehydrogenase E1 component 538 861 3.1E-55 T 09-03-2017 IPR001017 Dehydrogenase, E1 component GO:0008152|GO:0016624 TK78_RS10005 e38676914547574e43097c4e5eb081ee 1271 TIGRFAM TIGR00239 2oxo_dh_E1: oxoglutarate dehydrogenase (succinyl-transferring), E1 component 416 1269 0.0 T 09-03-2017 IPR011603 2-oxoglutarate dehydrogenase E1 component GO:0004591|GO:0006099|GO:0030976|GO:0055114 KEGG: 00020+1.2.4.2|KEGG: 00310+1.2.4.2|KEGG: 00380+1.2.4.2|MetaCyc: PWY-5084 TK78_RS10005 e38676914547574e43097c4e5eb081ee 1271 Pfam PF16870 2-oxoglutarate dehydrogenase C-terminal 1121 1269 4.1E-43 T 09-03-2017 IPR031717 Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal KEGG: 00020+1.2.4.2|KEGG: 00310+1.2.4.2|KEGG: 00380+1.2.4.2|MetaCyc: PWY-5084 TK78_RS10005 e38676914547574e43097c4e5eb081ee 1271 Gene3D G3DSA:3.30.559.10 145 385 1.4E-50 T 09-03-2017 IPR023213 Chloramphenicol acetyltransferase-like domain Reactome: R-HSA-389661 TK78_RS10005 e38676914547574e43097c4e5eb081ee 1271 PIRSF PIRSF000157 11 1271 0.0 T 09-03-2017 IPR011603 2-oxoglutarate dehydrogenase E1 component GO:0004591|GO:0006099|GO:0030976|GO:0055114 KEGG: 00020+1.2.4.2|KEGG: 00310+1.2.4.2|KEGG: 00380+1.2.4.2|MetaCyc: PWY-5084 TK78_RS10005 e38676914547574e43097c4e5eb081ee 1271 Gene3D G3DSA:3.40.50.970 494 862 8.2E-80 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS10005 e38676914547574e43097c4e5eb081ee 1271 Pfam PF02779 Transketolase, pyrimidine binding domain 922 1115 1.4E-58 T 09-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain TK78_RS10005 e38676914547574e43097c4e5eb081ee 1271 SMART SM00861 923 1116 3.2E-53 T 09-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain TK78_RS10005 e38676914547574e43097c4e5eb081ee 1271 Pfam PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain) 155 385 5.6E-50 T 09-03-2017 IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 TK78_RS10005 e38676914547574e43097c4e5eb081ee 1271 SUPERFAMILY SSF52518 453 866 2.36E-86 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS10005 e38676914547574e43097c4e5eb081ee 1271 Gene3D G3DSA:3.40.50.970 925 1127 2.3E-23 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS10005 e38676914547574e43097c4e5eb081ee 1271 SUPERFAMILY SSF52777 146 385 3.83E-54 T 09-03-2017 TK78_RS10005 e38676914547574e43097c4e5eb081ee 1271 SUPERFAMILY SSF52518 913 1122 8.24E-47 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS10005 e38676914547574e43097c4e5eb081ee 1271 Pfam PF16078 2-oxoglutarate dehydrogenase N-terminus 24 61 5.7E-12 T 09-03-2017 IPR032106 2-oxoglutarate dehydrogenase E1 component, N-terminal domain KEGG: 00020+1.2.4.2|KEGG: 00310+1.2.4.2|KEGG: 00380+1.2.4.2|MetaCyc: PWY-5084 TK78_RS34580 1df22f79f945d6550920e2cf35ed4095 1202 Gene3D G3DSA:3.40.640.10 726 942 1.5E-71 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS34580 1df22f79f945d6550920e2cf35ed4095 1202 Pfam PF13193 AMP-binding enzyme C-terminal domain 424 497 1.1E-13 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS34580 1df22f79f945d6550920e2cf35ed4095 1202 Gene3D G3DSA:3.40.50.980 17 176 1.2E-43 T 09-03-2017 TK78_RS34580 1df22f79f945d6550920e2cf35ed4095 1202 SUPERFAMILY SSF47336 537 622 5.76E-11 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS34580 1df22f79f945d6550920e2cf35ed4095 1202 Gene3D G3DSA:2.30.38.10 326 406 2.7E-22 T 09-03-2017 TK78_RS34580 1df22f79f945d6550920e2cf35ed4095 1202 Gene3D G3DSA:3.30.300.30 410 509 5.3E-32 T 09-03-2017 TK78_RS34580 1df22f79f945d6550920e2cf35ed4095 1202 ProSitePatterns PS00455 Putative AMP-binding domain signature. 168 179 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS34580 1df22f79f945d6550920e2cf35ed4095 1202 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 46 440 2.0E-119 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS34580 1df22f79f945d6550920e2cf35ed4095 1202 SUPERFAMILY SSF53383 685 1055 2.31E-91 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS34580 1df22f79f945d6550920e2cf35ed4095 1202 Pfam PF00155 Aminotransferase class I and II 713 1052 4.4E-43 T 09-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TK78_RS34580 1df22f79f945d6550920e2cf35ed4095 1202 Gene3D G3DSA:3.40.50.980 177 325 3.8E-36 T 09-03-2017 TK78_RS34580 1df22f79f945d6550920e2cf35ed4095 1202 SUPERFAMILY SSF56801 14 507 7.85E-134 T 09-03-2017 TK78_RS34580 1df22f79f945d6550920e2cf35ed4095 1202 Gene3D G3DSA:1.10.1200.10 544 617 2.9E-7 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS34580 1df22f79f945d6550920e2cf35ed4095 1202 ProSitePatterns PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 907 916 - T 09-03-2017 IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site GO:0008152|GO:0016740 TK78_RS34580 1df22f79f945d6550920e2cf35ed4095 1202 Gene3D G3DSA:3.90.1150.10 943 1053 6.7E-19 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS34580 1df22f79f945d6550920e2cf35ed4095 1202 Pfam PF00501 AMP-binding enzyme 28 416 2.7E-89 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS34580 1df22f79f945d6550920e2cf35ed4095 1202 Pfam PF00550 Phosphopantetheine attachment site 566 614 5.9E-5 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01150 0475d0862af66f93890347886123287b 537 SUPERFAMILY SSF52743 134 414 1.17E-72 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS01150 0475d0862af66f93890347886123287b 537 ProSitePatterns PS00137 Serine proteases, subtilase family, histidine active site. 199 209 - T 09-03-2017 IPR022398 Peptidase S8, subtilisin, His-active site TK78_RS01150 0475d0862af66f93890347886123287b 537 Pfam PF01483 Proprotein convertase P-domain 458 537 1.1E-18 T 09-03-2017 IPR002884 Proprotein convertase, P GO:0004252|GO:0006508 TK78_RS01150 0475d0862af66f93890347886123287b 537 Gene3D G3DSA:3.30.70.80 50 129 4.2E-18 T 09-03-2017 IPR010259 Peptidase S8 propeptide/proteinase inhibitor I9 TK78_RS01150 0475d0862af66f93890347886123287b 537 Pfam PF00082 Subtilase family 158 395 8.6E-40 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS01150 0475d0862af66f93890347886123287b 537 Gene3D G3DSA:2.60.120.260 434 537 2.2E-14 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS01150 0475d0862af66f93890347886123287b 537 ProSitePatterns PS00138 Serine proteases, subtilase family, serine active site. 357 367 - T 09-03-2017 IPR023828 Peptidase S8, subtilisin, Ser-active site TK78_RS01150 0475d0862af66f93890347886123287b 537 Pfam PF05922 Peptidase inhibitor I9 56 121 1.9E-8 T 09-03-2017 IPR010259 Peptidase S8 propeptide/proteinase inhibitor I9 TK78_RS01150 0475d0862af66f93890347886123287b 537 SUPERFAMILY SSF49785 433 537 9.78E-23 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS01150 0475d0862af66f93890347886123287b 537 SUPERFAMILY SSF54897 54 124 5.04E-12 T 09-03-2017 IPR009020 Proteinase propeptide inhibitor TK78_RS01150 0475d0862af66f93890347886123287b 537 Gene3D G3DSA:3.40.50.200 135 399 8.6E-80 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS01150 0475d0862af66f93890347886123287b 537 ProSitePatterns PS00136 Serine proteases, subtilase family, aspartic acid active site. 162 173 - T 09-03-2017 IPR023827 Peptidase S8, subtilisin, Asp-active site TK78_RS01150 0475d0862af66f93890347886123287b 537 PRINTS PR00723 Subtilisin serine protease family (S8) signature 157 176 2.9E-17 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS01150 0475d0862af66f93890347886123287b 537 PRINTS PR00723 Subtilisin serine protease family (S8) signature 195 208 2.9E-17 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS01150 0475d0862af66f93890347886123287b 537 PRINTS PR00723 Subtilisin serine protease family (S8) signature 356 372 2.9E-17 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS05950 a8f40a61ccfe7a36a516f36433e2e77f 957 Pfam PF17101 Stealth protein CR1, conserved region 1 628 652 1.4E-11 T 09-03-2017 IPR031358 Stealth protein CR1, conserved region 1 TK78_RS05950 a8f40a61ccfe7a36a516f36433e2e77f 957 Gene3D G3DSA:3.40.50.2000 208 360 2.7E-20 T 09-03-2017 TK78_RS05950 a8f40a61ccfe7a36a516f36433e2e77f 957 SUPERFAMILY SSF53756 90 381 3.4E-63 T 09-03-2017 TK78_RS05950 a8f40a61ccfe7a36a516f36433e2e77f 957 SUPERFAMILY SSF53756 2 59 3.4E-63 T 09-03-2017 TK78_RS05950 a8f40a61ccfe7a36a516f36433e2e77f 957 Pfam PF13439 Glycosyltransferase Family 4 13 195 6.2E-9 T 09-03-2017 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 TK78_RS05950 a8f40a61ccfe7a36a516f36433e2e77f 957 Pfam PF11380 Stealth protein CR2, conserved region 2 668 773 4.6E-45 T 09-03-2017 IPR021520 Stealth protein CR2, conserved region 2 GO:0016772 TK78_RS05950 a8f40a61ccfe7a36a516f36433e2e77f 957 Pfam PF17102 Stealth protein CR3, conserved region 3 819 866 2.8E-17 T 09-03-2017 IPR031357 Stealth protein CR3, conserved region 3 TK78_RS05950 a8f40a61ccfe7a36a516f36433e2e77f 957 Pfam PF17103 Stealth protein CR4, conserved region 4 894 947 2.2E-14 T 09-03-2017 IPR031356 Stealth protein CR4, conserved region 4 TK78_RS05950 a8f40a61ccfe7a36a516f36433e2e77f 957 Pfam PF00534 Glycosyl transferases group 1 207 360 4.4E-34 T 09-03-2017 IPR001296 Glycosyl transferase, family 1 TK78_RS18530 2327b031edd7d9a68e53b4f8ef0e1442 320 SUPERFAMILY SSF52540 2 222 2.77E-55 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18530 2327b031edd7d9a68e53b4f8ef0e1442 320 Gene3D G3DSA:3.40.50.300 1 224 1.8E-57 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18530 2327b031edd7d9a68e53b4f8ef0e1442 320 Pfam PF00005 ABC transporter 18 156 1.5E-23 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS18530 2327b031edd7d9a68e53b4f8ef0e1442 320 SMART SM00382 26 204 4.2E-10 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS12090 746da83ea661a3afcf58e464a744c431 509 Pfam PF00672 HAMP domain 194 261 1.3E-13 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS12090 746da83ea661a3afcf58e464a744c431 509 SMART SM00387 380 489 3.0E-33 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS12090 746da83ea661a3afcf58e464a744c431 509 Gene3D G3DSA:3.30.565.10 328 488 3.7E-40 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS12090 746da83ea661a3afcf58e464a744c431 509 SMART SM00304 213 265 6.4E-13 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS12090 746da83ea661a3afcf58e464a744c431 509 SMART SM00388 273 340 7.6E-18 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS12090 746da83ea661a3afcf58e464a744c431 509 SUPERFAMILY SSF47384 259 340 9.42E-17 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS12090 746da83ea661a3afcf58e464a744c431 509 SUPERFAMILY SSF158472 215 262 5.75E-8 T 09-03-2017 TK78_RS12090 746da83ea661a3afcf58e464a744c431 509 Pfam PF00512 His Kinase A (phospho-acceptor) domain 275 340 2.6E-16 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS12090 746da83ea661a3afcf58e464a744c431 509 PRINTS PR00344 Bacterial sensor protein C-terminal signature 449 467 2.4E-15 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS12090 746da83ea661a3afcf58e464a744c431 509 PRINTS PR00344 Bacterial sensor protein C-terminal signature 473 486 2.4E-15 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS12090 746da83ea661a3afcf58e464a744c431 509 PRINTS PR00344 Bacterial sensor protein C-terminal signature 433 443 2.4E-15 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS12090 746da83ea661a3afcf58e464a744c431 509 PRINTS PR00344 Bacterial sensor protein C-terminal signature 415 429 2.4E-15 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS12090 746da83ea661a3afcf58e464a744c431 509 SUPERFAMILY SSF55874 330 487 5.89E-37 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS12090 746da83ea661a3afcf58e464a744c431 509 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 381 488 2.5E-22 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS12090 746da83ea661a3afcf58e464a744c431 509 Gene3D G3DSA:1.10.287.130 265 327 5.3E-16 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS31115 093a0ffea20b0d0cf236904a613cc549 208 Pfam PF00881 Nitroreductase family 29 185 9.7E-17 T 09-03-2017 IPR029479 Nitroreductase Reactome: R-HSA-209968 TK78_RS31115 093a0ffea20b0d0cf236904a613cc549 208 SUPERFAMILY SSF55469 25 205 3.4E-41 T 09-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TK78_RS31115 093a0ffea20b0d0cf236904a613cc549 208 Gene3D G3DSA:3.40.109.10 23 206 1.6E-39 T 09-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TK78_RS07125 2681e2e6388b3ed282f797dd8a3b73b2 336 TIGRFAM TIGR00747 fabH: 3-oxoacyl-[acyl-carrier-protein] synthase III 6 328 6.9E-90 T 09-03-2017 IPR004655 3-oxoacyl-[acyl-carrier-protein] synthase 3 GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 TK78_RS07125 2681e2e6388b3ed282f797dd8a3b73b2 336 Pfam PF08541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal 239 328 9.1E-25 T 09-03-2017 IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, C-terminal KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 TK78_RS07125 2681e2e6388b3ed282f797dd8a3b73b2 336 Gene3D G3DSA:3.40.47.10 1 163 2.6E-55 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS07125 2681e2e6388b3ed282f797dd8a3b73b2 336 SUPERFAMILY SSF53901 5 328 2.18E-56 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS07125 2681e2e6388b3ed282f797dd8a3b73b2 336 Pfam PF08545 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III 109 186 2.2E-20 T 09-03-2017 IPR013751 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 TK78_RS07125 2681e2e6388b3ed282f797dd8a3b73b2 336 Gene3D G3DSA:3.40.47.10 164 328 3.0E-37 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS34420 fe54cac27215b107d49a95f85894dc92 346 Gene3D G3DSA:3.40.50.720 178 291 2.9E-22 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS34420 fe54cac27215b107d49a95f85894dc92 346 SUPERFAMILY SSF51735 150 310 6.91E-44 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS34420 fe54cac27215b107d49a95f85894dc92 346 SUPERFAMILY SSF50129 7 172 6.51E-53 T 09-03-2017 IPR011032 GroES-like TK78_RS34420 fe54cac27215b107d49a95f85894dc92 346 Gene3D G3DSA:3.90.180.10 2 177 4.1E-65 T 09-03-2017 IPR011032 GroES-like TK78_RS34420 fe54cac27215b107d49a95f85894dc92 346 Pfam PF00107 Zinc-binding dehydrogenase 185 306 1.7E-23 T 09-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 TK78_RS34420 fe54cac27215b107d49a95f85894dc92 346 SMART SM00829 14 341 1.3E-6 T 09-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 TK78_RS34420 fe54cac27215b107d49a95f85894dc92 346 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 30 143 2.1E-27 T 09-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 TK78_RS34420 fe54cac27215b107d49a95f85894dc92 346 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 62 76 - T 09-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 TK78_RS08000 e5812b6072c901e8311cccfff4a23424 163 SUPERFAMILY SSF54909 80 159 3.62E-15 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS08000 e5812b6072c901e8311cccfff4a23424 163 SMART SM00344 18 122 1.8E-34 T 09-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 TK78_RS08000 e5812b6072c901e8311cccfff4a23424 163 Gene3D G3DSA:1.10.10.10 18 65 2.5E-16 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS08000 e5812b6072c901e8311cccfff4a23424 163 Pfam PF01037 Lrp/AsnC ligand binding domain 83 152 6.2E-15 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS08000 e5812b6072c901e8311cccfff4a23424 163 Pfam PF13404 AsnC-type helix-turn-helix domain 19 58 8.7E-15 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS08000 e5812b6072c901e8311cccfff4a23424 163 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 34 45 5.4E-11 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS08000 e5812b6072c901e8311cccfff4a23424 163 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 18 34 5.4E-11 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS08000 e5812b6072c901e8311cccfff4a23424 163 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 45 64 5.4E-11 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS08000 e5812b6072c901e8311cccfff4a23424 163 SUPERFAMILY SSF46785 18 72 1.22E-9 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS08000 e5812b6072c901e8311cccfff4a23424 163 ProSitePatterns PS00519 AsnC-type HTH domain signature. 36 62 - T 09-03-2017 IPR019885 Transcription regulator HTH, AsnC-type, conserved site TK78_RS08000 e5812b6072c901e8311cccfff4a23424 163 Gene3D G3DSA:3.30.70.920 81 152 5.9E-17 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS03330 30a53ea39ef658867e76902b5644f45f 379 SUPERFAMILY SSF89796 10 369 5.1E-117 T 09-03-2017 IPR023606 CoA-transferase family III domain TK78_RS03330 30a53ea39ef658867e76902b5644f45f 379 Pfam PF02515 CoA-transferase family III 12 361 2.1E-87 T 09-03-2017 IPR003673 CoA-transferase family III GO:0003824 TK78_RS03330 30a53ea39ef658867e76902b5644f45f 379 Gene3D G3DSA:3.40.50.10540 9 214 4.5E-99 T 09-03-2017 IPR023606 CoA-transferase family III domain TK78_RS03330 30a53ea39ef658867e76902b5644f45f 379 Gene3D G3DSA:3.40.50.10540 299 368 4.5E-99 T 09-03-2017 IPR023606 CoA-transferase family III domain TK78_RS03330 30a53ea39ef658867e76902b5644f45f 379 Gene3D G3DSA:3.30.1540.10 230 298 4.0E-9 T 09-03-2017 TK78_RS17005 88fa4c314af711a4718f1e1d8918a8ed 274 SUPERFAMILY SSF56784 4 265 6.31E-59 T 09-03-2017 IPR023214 HAD-like domain TK78_RS17005 88fa4c314af711a4718f1e1d8918a8ed 274 TIGRFAM TIGR00099 Cof-subfamily: Cof-like hydrolase 7 261 8.3E-46 T 09-03-2017 IPR000150 Cof protein GO:0016787 TK78_RS17005 88fa4c314af711a4718f1e1d8918a8ed 274 Gene3D G3DSA:3.40.50.1000 4 75 1.4E-52 T 09-03-2017 IPR023214 HAD-like domain TK78_RS17005 88fa4c314af711a4718f1e1d8918a8ed 274 Gene3D G3DSA:3.40.50.1000 170 266 1.4E-52 T 09-03-2017 IPR023214 HAD-like domain TK78_RS17005 88fa4c314af711a4718f1e1d8918a8ed 274 Pfam PF08282 haloacid dehalogenase-like hydrolase 8 261 1.7E-46 T 09-03-2017 IPR023214 HAD-like domain TK78_RS17005 88fa4c314af711a4718f1e1d8918a8ed 274 TIGRFAM TIGR01484 HAD-SF-IIB: HAD hydrolase, family IIB 7 234 2.2E-23 T 09-03-2017 IPR006379 HAD-superfamily hydrolase, subfamily IIB Reactome: R-HSA-446205 TK78_RS12030 071bb93e887850252de499aef04bad8e 145 Pfam PF13772 AIG2-like family 59 140 3.9E-20 T 09-03-2017 TK78_RS12030 071bb93e887850252de499aef04bad8e 145 SUPERFAMILY SSF110857 1 119 3.53E-13 T 09-03-2017 IPR013024 Butirosin biosynthesis, BtrG-like TK78_RS12030 071bb93e887850252de499aef04bad8e 145 Gene3D G3DSA:3.10.490.10 1 145 1.5E-45 T 09-03-2017 IPR013024 Butirosin biosynthesis, BtrG-like TK78_RS09455 9071ad8372567d57b38e604014938dc9 169 PRINTS PR00598 Bacterial regulatory protein MarR family signature 110 126 5.6E-5 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS09455 9071ad8372567d57b38e604014938dc9 169 PRINTS PR00598 Bacterial regulatory protein MarR family signature 91 106 5.6E-5 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS09455 9071ad8372567d57b38e604014938dc9 169 PRINTS PR00598 Bacterial regulatory protein MarR family signature 74 90 5.6E-5 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS09455 9071ad8372567d57b38e604014938dc9 169 Gene3D G3DSA:1.10.10.10 28 160 7.4E-31 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS09455 9071ad8372567d57b38e604014938dc9 169 SMART SM00347 48 149 5.5E-20 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS09455 9071ad8372567d57b38e604014938dc9 169 SUPERFAMILY SSF46785 26 160 2.26E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS09455 9071ad8372567d57b38e604014938dc9 169 ProSitePatterns PS01117 MarR-type HTH domain signature. 89 123 - T 09-03-2017 IPR023187 Transcriptional regulator MarR-type, conserved site TK78_RS09455 9071ad8372567d57b38e604014938dc9 169 Pfam PF01047 MarR family 62 113 2.2E-12 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS31360 b1f1d244e747c3e36851acd0fc6bfcd3 726 Gene3D G3DSA:1.20.1640.10 160 353 2.8E-28 T 09-03-2017 TK78_RS31360 b1f1d244e747c3e36851acd0fc6bfcd3 726 Gene3D G3DSA:1.20.1640.10 511 711 1.6E-33 T 09-03-2017 TK78_RS31360 b1f1d244e747c3e36851acd0fc6bfcd3 726 Pfam PF03176 MMPL family 449 707 1.7E-39 T 09-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 TK78_RS31360 b1f1d244e747c3e36851acd0fc6bfcd3 726 Pfam PF03176 MMPL family 68 386 9.7E-63 T 09-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 TK78_RS31360 b1f1d244e747c3e36851acd0fc6bfcd3 726 SUPERFAMILY SSF82866 142 352 3.4E-36 T 09-03-2017 TK78_RS31360 b1f1d244e747c3e36851acd0fc6bfcd3 726 SUPERFAMILY SSF82866 480 706 4.58E-29 T 09-03-2017 TK78_RS03985 cedc78a40f4541350b48ac9c5fdc0802 306 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 43 54 1.0E-7 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS03985 cedc78a40f4541350b48ac9c5fdc0802 306 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 22 33 1.0E-7 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS03985 cedc78a40f4541350b48ac9c5fdc0802 306 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 33 43 1.0E-7 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS03985 cedc78a40f4541350b48ac9c5fdc0802 306 SUPERFAMILY SSF46785 4 113 3.15E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS03985 cedc78a40f4541350b48ac9c5fdc0802 306 Pfam PF03466 LysR substrate binding domain 90 276 7.4E-29 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS03985 cedc78a40f4541350b48ac9c5fdc0802 306 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 9 66 5.8E-21 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS03985 cedc78a40f4541350b48ac9c5fdc0802 306 Gene3D G3DSA:3.40.190.10 88 189 1.7E-18 T 09-03-2017 TK78_RS03985 cedc78a40f4541350b48ac9c5fdc0802 306 Gene3D G3DSA:3.40.190.10 190 245 1.0E-7 T 09-03-2017 TK78_RS03985 cedc78a40f4541350b48ac9c5fdc0802 306 SUPERFAMILY SSF53850 91 279 3.37E-27 T 09-03-2017 TK78_RS03985 cedc78a40f4541350b48ac9c5fdc0802 306 Gene3D G3DSA:1.10.10.10 6 83 7.1E-25 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS04885 5405b6958ddf1c16af072043f18b30e9 267 Gene3D G3DSA:3.30.450.40 94 259 1.9E-60 T 09-03-2017 IPR029016 GAF domain-like TK78_RS04885 5405b6958ddf1c16af072043f18b30e9 267 Pfam PF01614 Bacterial transcriptional regulator 135 257 8.5E-31 T 09-03-2017 IPR014757 Transcription regulator IclR, C-terminal TK78_RS04885 5405b6958ddf1c16af072043f18b30e9 267 SUPERFAMILY SSF55781 77 259 1.31E-49 T 09-03-2017 IPR029016 GAF domain-like TK78_RS04885 5405b6958ddf1c16af072043f18b30e9 267 SUPERFAMILY SSF46785 20 90 1.58E-18 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS04885 5405b6958ddf1c16af072043f18b30e9 267 Gene3D G3DSA:1.10.10.10 18 92 1.2E-25 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS04885 5405b6958ddf1c16af072043f18b30e9 267 Pfam PF09339 IclR helix-turn-helix domain 22 73 1.2E-17 T 09-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 TK78_RS04885 5405b6958ddf1c16af072043f18b30e9 267 SMART SM00346 20 107 1.0E-21 T 09-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 TK78_RS07095 eba74684baabd4f0b67c9c077101d1a4 335 SUPERFAMILY SSF52540 5 228 4.61E-61 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07095 eba74684baabd4f0b67c9c077101d1a4 335 Pfam PF00005 ABC transporter 22 165 2.3E-27 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS07095 eba74684baabd4f0b67c9c077101d1a4 335 Gene3D G3DSA:3.40.50.300 4 232 2.4E-68 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07095 eba74684baabd4f0b67c9c077101d1a4 335 Pfam PF13732 Domain of unknown function (DUF4162) 219 299 1.0E-8 T 09-03-2017 IPR025302 Domain of unknown function DUF4162 TK78_RS07095 eba74684baabd4f0b67c9c077101d1a4 335 ProSitePatterns PS00211 ABC transporters family signature. 138 152 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS07095 eba74684baabd4f0b67c9c077101d1a4 335 SMART SM00382 31 214 1.9E-10 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS07095 eba74684baabd4f0b67c9c077101d1a4 335 TIGRFAM TIGR01188 drrA: daunorubicin resistance ABC transporter, ATP-binding protein 14 302 2.2E-102 T 09-03-2017 IPR005894 Daunorubicin resistance ABC transporter ATP-binding subunit DrrA GO:0005524|GO:0043215|GO:1900753 TK78_RS30070 57474975191c5a7e82557324aefeea65 741 SUPERFAMILY SSF52540 21 310 3.05E-53 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS30070 57474975191c5a7e82557324aefeea65 741 Pfam PF00009 Elongation factor Tu GTP binding domain 24 203 4.5E-28 T 09-03-2017 TK78_RS30070 57474975191c5a7e82557324aefeea65 741 SUPERFAMILY SSF54211 522 639 2.78E-34 T 09-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold TK78_RS30070 57474975191c5a7e82557324aefeea65 741 Pfam PF00679 Elongation factor G C-terminus 642 729 5.5E-22 T 09-03-2017 IPR000640 Translation elongation factor EFG, V domain TK78_RS30070 57474975191c5a7e82557324aefeea65 741 Gene3D G3DSA:3.40.50.300 21 315 8.6E-54 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS30070 57474975191c5a7e82557324aefeea65 741 SMART SM00889 522 640 2.4E-57 T 09-03-2017 IPR005517 Translation elongation factor EFG/EF2, domain IV GO:0005525 TK78_RS30070 57474975191c5a7e82557324aefeea65 741 SUPERFAMILY SSF54980 645 731 9.35E-22 T 09-03-2017 IPR009022 Elongation factor G, III-V domain TK78_RS30070 57474975191c5a7e82557324aefeea65 741 Pfam PF14492 Elongation Factor G, domain II 447 518 5.3E-24 T 09-03-2017 IPR009022 Elongation factor G, III-V domain TK78_RS30070 57474975191c5a7e82557324aefeea65 741 Gene3D G3DSA:3.30.230.10 526 644 3.1E-46 T 09-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TK78_RS30070 57474975191c5a7e82557324aefeea65 741 Gene3D G3DSA:3.30.70.240 645 731 8.5E-22 T 09-03-2017 IPR000640 Translation elongation factor EFG, V domain TK78_RS30070 57474975191c5a7e82557324aefeea65 741 Pfam PF03764 Elongation factor G, domain IV 522 639 1.4E-38 T 09-03-2017 IPR005517 Translation elongation factor EFG/EF2, domain IV GO:0005525 TK78_RS30070 57474975191c5a7e82557324aefeea65 741 SUPERFAMILY SSF54980 447 524 9.35E-19 T 09-03-2017 IPR009022 Elongation factor G, III-V domain TK78_RS30070 57474975191c5a7e82557324aefeea65 741 SMART SM00838 642 730 8.6E-21 T 09-03-2017 IPR000640 Translation elongation factor EFG, V domain TK78_RS30070 57474975191c5a7e82557324aefeea65 741 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 25 162 3.7E-12 T 09-03-2017 IPR005225 Small GTP-binding protein domain GO:0005525 TK78_RS30070 57474975191c5a7e82557324aefeea65 741 Gene3D G3DSA:2.40.30.10 333 447 2.9E-25 T 09-03-2017 TK78_RS30070 57474975191c5a7e82557324aefeea65 741 SUPERFAMILY SSF50447 295 443 1.04E-22 T 09-03-2017 IPR009000 Translation protein, beta-barrel domain TK78_RS30070 57474975191c5a7e82557324aefeea65 741 Gene3D G3DSA:3.30.70.870 448 519 1.7E-24 T 09-03-2017 TK78_RS30070 57474975191c5a7e82557324aefeea65 741 Pfam PF03144 Elongation factor Tu domain 2 353 432 1.9E-8 T 09-03-2017 IPR004161 Translation elongation factor EFTu-like, domain 2 GO:0005525 TK78_RS24770 678c7e637bd9fe551ace76dbed95c9c4 379 Gene3D G3DSA:1.10.287.110 3 95 3.9E-33 T 09-03-2017 IPR001623 DnaJ domain TK78_RS24770 678c7e637bd9fe551ace76dbed95c9c4 379 SUPERFAMILY SSF49493 259 345 7.19E-21 T 09-03-2017 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 TK78_RS24770 678c7e637bd9fe551ace76dbed95c9c4 379 Gene3D G3DSA:2.10.230.10 138 210 1.3E-19 T 09-03-2017 IPR001305 Heat shock protein DnaJ, cysteine-rich domain GO:0031072|GO:0051082 TK78_RS24770 678c7e637bd9fe551ace76dbed95c9c4 379 SUPERFAMILY SSF49493 116 149 4.32E-20 T 09-03-2017 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 TK78_RS24770 678c7e637bd9fe551ace76dbed95c9c4 379 SUPERFAMILY SSF49493 214 257 4.32E-20 T 09-03-2017 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 TK78_RS24770 678c7e637bd9fe551ace76dbed95c9c4 379 Gene3D G3DSA:2.60.260.20 96 137 4.8E-22 T 09-03-2017 TK78_RS24770 678c7e637bd9fe551ace76dbed95c9c4 379 Gene3D G3DSA:2.60.260.20 211 254 4.8E-22 T 09-03-2017 TK78_RS24770 678c7e637bd9fe551ace76dbed95c9c4 379 SUPERFAMILY SSF57938 131 211 2.49E-18 T 09-03-2017 IPR001305 Heat shock protein DnaJ, cysteine-rich domain GO:0031072|GO:0051082 TK78_RS24770 678c7e637bd9fe551ace76dbed95c9c4 379 Hamap MF_01152 Chaperone protein DnaJ [dnaJ]. 1 375 38.095 T 09-03-2017 IPR012724 Chaperone DnaJ GO:0005524|GO:0006457|GO:0009408|GO:0051082 TK78_RS24770 678c7e637bd9fe551ace76dbed95c9c4 379 Pfam PF00226 DnaJ domain 4 65 5.2E-26 T 09-03-2017 IPR001623 DnaJ domain TK78_RS24770 678c7e637bd9fe551ace76dbed95c9c4 379 Pfam PF01556 DnaJ C terminal domain 119 334 1.2E-38 T 09-03-2017 IPR002939 Chaperone DnaJ, C-terminal TK78_RS24770 678c7e637bd9fe551ace76dbed95c9c4 379 SMART SM00271 3 60 5.6E-31 T 09-03-2017 IPR001623 DnaJ domain TK78_RS24770 678c7e637bd9fe551ace76dbed95c9c4 379 TIGRFAM TIGR02349 DnaJ_bact: chaperone protein DnaJ 4 350 3.2E-119 T 09-03-2017 IPR012724 Chaperone DnaJ GO:0005524|GO:0006457|GO:0009408|GO:0051082 TK78_RS24770 678c7e637bd9fe551ace76dbed95c9c4 379 PRINTS PR00625 DnaJ domain signature 24 39 1.1E-24 T 09-03-2017 IPR001623 DnaJ domain TK78_RS24770 678c7e637bd9fe551ace76dbed95c9c4 379 PRINTS PR00625 DnaJ domain signature 60 79 1.1E-24 T 09-03-2017 IPR001623 DnaJ domain TK78_RS24770 678c7e637bd9fe551ace76dbed95c9c4 379 PRINTS PR00625 DnaJ domain signature 6 24 1.1E-24 T 09-03-2017 IPR001623 DnaJ domain TK78_RS24770 678c7e637bd9fe551ace76dbed95c9c4 379 PRINTS PR00625 DnaJ domain signature 40 60 1.1E-24 T 09-03-2017 IPR001623 DnaJ domain TK78_RS24770 678c7e637bd9fe551ace76dbed95c9c4 379 Pfam PF00684 DnaJ central domain 144 208 1.1E-12 T 09-03-2017 IPR001305 Heat shock protein DnaJ, cysteine-rich domain GO:0031072|GO:0051082 TK78_RS24770 678c7e637bd9fe551ace76dbed95c9c4 379 ProSitePatterns PS00636 Nt-dnaJ domain signature. 45 64 - T 09-03-2017 IPR018253 DnaJ domain, conserved site TK78_RS24770 678c7e637bd9fe551ace76dbed95c9c4 379 Gene3D G3DSA:2.60.260.20 257 334 4.9E-20 T 09-03-2017 TK78_RS24770 678c7e637bd9fe551ace76dbed95c9c4 379 SUPERFAMILY SSF46565 3 100 5.36E-33 T 09-03-2017 IPR001623 DnaJ domain TK78_RS22880 52abf8f29e16bfa1792bdc8b173301e1 152 TIGRFAM TIGR00632 vsr: DNA mismatch endonuclease Vsr 16 129 2.6E-39 T 09-03-2017 IPR004603 DNA mismatch endonuclease vsr GO:0004519|GO:0006298 TK78_RS22880 52abf8f29e16bfa1792bdc8b173301e1 152 SUPERFAMILY SSF52980 16 135 3.0E-36 T 09-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 TK78_RS22880 52abf8f29e16bfa1792bdc8b173301e1 152 Pfam PF03852 DNA mismatch endonuclease Vsr 18 83 2.7E-19 T 09-03-2017 IPR004603 DNA mismatch endonuclease vsr GO:0004519|GO:0006298 TK78_RS22880 52abf8f29e16bfa1792bdc8b173301e1 152 Gene3D G3DSA:3.40.960.10 31 140 1.3E-40 T 09-03-2017 IPR004603 DNA mismatch endonuclease vsr GO:0004519|GO:0006298 TK78_RS32900 eaa7d79802aa1c3106699e74bba4c7db 261 SUPERFAMILY SSF53681 2 102 2.48E-20 T 09-03-2017 IPR001920 Asp/Glu racemase GO:0008152|GO:0016855 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS32900 eaa7d79802aa1c3106699e74bba4c7db 261 Pfam PF01177 Asp/Glu/Hydantoin racemase 34 192 1.7E-12 T 09-03-2017 IPR015942 Asp/Glu/hydantoin racemase GO:0006807|GO:0036361 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS32900 eaa7d79802aa1c3106699e74bba4c7db 261 Gene3D G3DSA:3.40.50.1860 2 154 8.9E-35 T 09-03-2017 IPR001920 Asp/Glu racemase GO:0008152|GO:0016855 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS32900 eaa7d79802aa1c3106699e74bba4c7db 261 SUPERFAMILY SSF53681 106 220 2.05E-17 T 09-03-2017 IPR001920 Asp/Glu racemase GO:0008152|GO:0016855 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS32900 eaa7d79802aa1c3106699e74bba4c7db 261 ProSitePatterns PS00923 Aspartate and glutamate racemases signature 1. 67 75 - T 09-03-2017 IPR018187 Asp/Glu racemase, active site 1 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS32480 dbf25c3e280f4895efc3a2354eda3551 460 Gene3D G3DSA:3.40.605.10 3 244 3.0E-93 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS32480 dbf25c3e280f4895efc3a2354eda3551 460 SUPERFAMILY SSF53720 4 456 8.38E-159 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS32480 dbf25c3e280f4895efc3a2354eda3551 460 Gene3D G3DSA:3.40.309.10 245 434 6.2E-61 T 09-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 TK78_RS32480 dbf25c3e280f4895efc3a2354eda3551 460 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 230 237 - T 09-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 TK78_RS32480 dbf25c3e280f4895efc3a2354eda3551 460 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 258 269 - T 09-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 TK78_RS32480 dbf25c3e280f4895efc3a2354eda3551 460 Pfam PF00171 Aldehyde dehydrogenase family 4 454 3.9E-166 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS22920 a37019d51b210babfc4da8414b0dfb95 286 SUPERFAMILY SSF56529 66 283 2.35E-73 T 09-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 TK78_RS22920 a37019d51b210babfc4da8414b0dfb95 286 Gene3D G3DSA:3.90.850.10 69 284 1.3E-80 T 09-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 TK78_RS22920 a37019d51b210babfc4da8414b0dfb95 286 Pfam PF01557 Fumarylacetoacetate (FAA) hydrolase family 76 282 1.7E-65 T 09-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 TK78_RS30385 aa427ca099c92cf6eb139ea9aa883804 331 SUPERFAMILY SSF100950 67 312 2.56E-55 T 09-03-2017 TK78_RS30385 aa427ca099c92cf6eb139ea9aa883804 331 Gene3D G3DSA:3.40.50.1360 56 312 8.6E-69 T 09-03-2017 TK78_RS30385 aa427ca099c92cf6eb139ea9aa883804 331 Pfam PF04198 Putative sugar-binding domain 63 312 3.6E-67 T 09-03-2017 IPR007324 Sugar-binding domain, putative GO:0030246 TK78_RS26905 f7bfdeae39295c690b95304990c86d03 417 SUPERFAMILY SSF55874 300 404 2.36E-13 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS26905 f7bfdeae39295c690b95304990c86d03 417 Gene3D G3DSA:3.30.565.10 295 406 1.3E-12 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS26905 f7bfdeae39295c690b95304990c86d03 417 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 312 404 2.5E-9 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS26905 f7bfdeae39295c690b95304990c86d03 417 SMART SM00387 307 406 0.0021 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS26905 f7bfdeae39295c690b95304990c86d03 417 Pfam PF07730 Histidine kinase 194 241 4.5E-6 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS24285 18027a1a75063c1743f607c575fe33d8 321 Gene3D G3DSA:3.40.50.1110 34 316 3.4E-63 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS24285 18027a1a75063c1743f607c575fe33d8 321 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 42 306 4.0E-18 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS24285 18027a1a75063c1743f607c575fe33d8 321 SUPERFAMILY SSF52266 38 316 7.33E-52 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS25650 d937c915c37c722828257b19ffdbac9b 219 Pfam PF01596 O-methyltransferase 22 218 1.3E-51 T 09-03-2017 IPR002935 O-methyltransferase, family 3 GO:0008171 TK78_RS25650 d937c915c37c722828257b19ffdbac9b 219 Gene3D G3DSA:3.40.50.150 8 219 3.6E-67 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS25650 d937c915c37c722828257b19ffdbac9b 219 SUPERFAMILY SSF53335 9 219 4.89E-44 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS14135 28bda0c59c7c3569f71f3babb644c0f2 211 SUPERFAMILY SSF51182 76 186 1.21E-21 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS14135 28bda0c59c7c3569f71f3babb644c0f2 211 SUPERFAMILY SSF47413 19 85 5.91E-17 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS14135 28bda0c59c7c3569f71f3babb644c0f2 211 SMART SM00530 25 80 5.4E-17 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS14135 28bda0c59c7c3569f71f3babb644c0f2 211 Gene3D G3DSA:2.60.120.10 97 188 4.5E-14 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS14135 28bda0c59c7c3569f71f3babb644c0f2 211 Pfam PF13560 Helix-turn-helix domain 22 80 2.3E-15 T 09-03-2017 TK78_RS14135 28bda0c59c7c3569f71f3babb644c0f2 211 Gene3D G3DSA:1.10.260.40 16 91 4.1E-20 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS14135 28bda0c59c7c3569f71f3babb644c0f2 211 Pfam PF07883 Cupin domain 124 186 3.1E-12 T 09-03-2017 IPR013096 Cupin 2, conserved barrel TK78_RS04470 81748d96f1b30675ae1f5f77bf64e622 348 Pfam PF00356 Bacterial regulatory proteins, lacI family 6 47 5.6E-13 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS04470 81748d96f1b30675ae1f5f77bf64e622 348 SMART SM00354 2 69 1.5E-18 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS04470 81748d96f1b30675ae1f5f77bf64e622 348 SUPERFAMILY SSF47413 4 49 1.62E-11 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS04470 81748d96f1b30675ae1f5f77bf64e622 348 Gene3D G3DSA:3.40.50.2300 171 328 8.5E-53 T 09-03-2017 TK78_RS04470 81748d96f1b30675ae1f5f77bf64e622 348 Gene3D G3DSA:3.40.50.2300 56 170 1.6E-25 T 09-03-2017 TK78_RS04470 81748d96f1b30675ae1f5f77bf64e622 348 Pfam PF13377 Periplasmic binding protein-like domain 172 327 2.1E-38 T 09-03-2017 TK78_RS04470 81748d96f1b30675ae1f5f77bf64e622 348 Gene3D G3DSA:1.10.260.40 5 47 6.7E-17 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS04470 81748d96f1b30675ae1f5f77bf64e622 348 SUPERFAMILY SSF53822 59 328 9.03E-66 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS02995 e149e0ee812a48e086afcffd18e10e4a 207 SUPERFAMILY SSF52540 18 192 1.3E-18 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS02995 e149e0ee812a48e086afcffd18e10e4a 207 Gene3D G3DSA:3.40.50.300 19 120 2.7E-10 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS02995 e149e0ee812a48e086afcffd18e10e4a 207 Pfam PF03029 Conserved hypothetical ATP binding protein 24 192 1.7E-28 T 09-03-2017 IPR004130 GPN-loop GTPase TK78_RS29675 598f00e44be64ec025089311d4e292e7 1073 SMART SM00487 288 527 9.4E-13 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS29675 598f00e44be64ec025089311d4e292e7 1073 Pfam PF04851 Type III restriction enzyme, res subunit 293 500 3.8E-11 T 09-03-2017 IPR006935 Helicase/UvrB, N-terminal GO:0003677|GO:0005524|GO:0016787 TK78_RS29675 598f00e44be64ec025089311d4e292e7 1073 SUPERFAMILY SSF52540 285 508 7.04E-23 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29675 598f00e44be64ec025089311d4e292e7 1073 Gene3D G3DSA:3.40.50.300 290 502 5.3E-15 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29675 598f00e44be64ec025089311d4e292e7 1073 Pfam PF04313 Type I restriction enzyme R protein N terminus (HSDR_N) 97 182 8.6E-10 T 09-03-2017 IPR007409 Restriction endonuclease, type I, HsdR, N-terminal GO:0003677|GO:0004519|GO:0006304 TK78_RS29560 870075e6c60610e7564ed22c08c20436 393 SUPERFAMILY SSF52743 34 325 3.93E-82 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS29560 870075e6c60610e7564ed22c08c20436 393 Gene3D G3DSA:3.40.50.200 27 326 8.5E-81 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS29560 870075e6c60610e7564ed22c08c20436 393 ProSitePatterns PS00136 Serine proteases, subtilase family, aspartic acid active site. 57 68 - T 09-03-2017 IPR023827 Peptidase S8, subtilisin, Asp-active site TK78_RS29560 870075e6c60610e7564ed22c08c20436 393 TIGRFAM TIGR03921 T7SS_mycosin: type VII secretion-associated serine protease mycosin 41 388 9.0E-98 T 09-03-2017 IPR023834 Type VII secretion system peptidase S8A, mycosin-1 TK78_RS29560 870075e6c60610e7564ed22c08c20436 393 Pfam PF00082 Subtilase family 52 315 7.5E-45 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS29560 870075e6c60610e7564ed22c08c20436 393 PRINTS PR00723 Subtilisin serine protease family (S8) signature 52 71 1.3E-14 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS29560 870075e6c60610e7564ed22c08c20436 393 PRINTS PR00723 Subtilisin serine protease family (S8) signature 92 105 1.3E-14 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS29560 870075e6c60610e7564ed22c08c20436 393 PRINTS PR00723 Subtilisin serine protease family (S8) signature 264 280 1.3E-14 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS32810 b8a5ad186f23266f8ab41aea1ecc0333 404 Gene3D G3DSA:3.30.420.40 88 230 1.9E-22 T 09-03-2017 TK78_RS32810 b8a5ad186f23266f8ab41aea1ecc0333 404 Gene3D G3DSA:3.30.420.40 231 378 2.1E-34 T 09-03-2017 TK78_RS32810 b8a5ad186f23266f8ab41aea1ecc0333 404 SUPERFAMILY SSF53067 224 399 1.12E-32 T 09-03-2017 TK78_RS32810 b8a5ad186f23266f8ab41aea1ecc0333 404 Pfam PF00480 ROK family 124 391 1.3E-30 T 09-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 TK78_RS32810 b8a5ad186f23266f8ab41aea1ecc0333 404 Gene3D G3DSA:1.10.10.10 23 82 5.6E-6 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32810 b8a5ad186f23266f8ab41aea1ecc0333 404 SUPERFAMILY SSF53067 89 216 8.1E-13 T 09-03-2017 TK78_RS08230 afe22369a172a9db298996d1dfbe8682 1240 SMART SM00968 512 679 1.7E-22 T 09-03-2017 IPR010935 SMCs flexible hinge GO:0005515|GO:0005524|GO:0005694|GO:0051276 TK78_RS08230 afe22369a172a9db298996d1dfbe8682 1240 SUPERFAMILY SSF75553 495 571 1.96E-21 T 09-03-2017 IPR010935 SMCs flexible hinge GO:0005515|GO:0005524|GO:0005694|GO:0051276 TK78_RS08230 afe22369a172a9db298996d1dfbe8682 1240 SUPERFAMILY SSF75553 625 724 1.96E-21 T 09-03-2017 IPR010935 SMCs flexible hinge GO:0005515|GO:0005524|GO:0005694|GO:0051276 TK78_RS08230 afe22369a172a9db298996d1dfbe8682 1240 Pfam PF02463 RecF/RecN/SMC N terminal domain 3 1232 9.1E-72 T 09-03-2017 IPR003395 RecF/RecN/SMC, N-terminal TK78_RS08230 afe22369a172a9db298996d1dfbe8682 1240 Hamap MF_01894 Chromosome partition protein Smc [smc]. 1 1240 22.63 T 09-03-2017 IPR011890 Structural maintenance of chromosomes protein, prokaryotic GO:0007062|GO:0030261 TK78_RS08230 afe22369a172a9db298996d1dfbe8682 1240 SUPERFAMILY SSF52540 2 210 1.11E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08230 afe22369a172a9db298996d1dfbe8682 1240 SUPERFAMILY SSF52540 1125 1232 1.11E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08230 afe22369a172a9db298996d1dfbe8682 1240 Gene3D G3DSA:3.40.50.300 2 163 1.5E-87 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08230 afe22369a172a9db298996d1dfbe8682 1240 Gene3D G3DSA:3.40.50.300 1088 1235 1.5E-87 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08230 afe22369a172a9db298996d1dfbe8682 1240 Pfam PF06470 SMC proteins Flexible Hinge Domain 512 679 8.8E-20 T 09-03-2017 IPR010935 SMCs flexible hinge GO:0005515|GO:0005524|GO:0005694|GO:0051276 TK78_RS21730 dc7dc8f46474060a51b2047ac863c177 436 SUPERFAMILY SSF53187 358 434 1.46E-69 T 09-03-2017 TK78_RS21730 dc7dc8f46474060a51b2047ac863c177 436 SUPERFAMILY SSF53187 33 247 1.46E-69 T 09-03-2017 TK78_RS21730 dc7dc8f46474060a51b2047ac863c177 436 Gene3D G3DSA:3.30.70.360 251 351 1.6E-27 T 09-03-2017 IPR011650 Peptidase M20, dimerisation domain TK78_RS21730 dc7dc8f46474060a51b2047ac863c177 436 SUPERFAMILY SSF55031 240 349 7.15E-19 T 09-03-2017 IPR011650 Peptidase M20, dimerisation domain TK78_RS21730 dc7dc8f46474060a51b2047ac863c177 436 Gene3D G3DSA:3.40.630.10 376 434 2.6E-92 T 09-03-2017 TK78_RS21730 dc7dc8f46474060a51b2047ac863c177 436 Gene3D G3DSA:3.40.630.10 30 250 2.6E-92 T 09-03-2017 TK78_RS21730 dc7dc8f46474060a51b2047ac863c177 436 TIGRFAM TIGR01879 hydantase: amidase, hydantoinase/carbamoylase family 38 429 1.6E-84 T 09-03-2017 IPR010158 Amidase, carbamoylase-type GO:0008152|GO:0016813 TK78_RS21730 dc7dc8f46474060a51b2047ac863c177 436 PIRSF PIRSF001235 26 436 7.1E-121 T 09-03-2017 IPR010158 Amidase, carbamoylase-type GO:0008152|GO:0016813 TK78_RS21730 dc7dc8f46474060a51b2047ac863c177 436 Pfam PF01546 Peptidase family M20/M25/M40 101 431 3.1E-25 T 09-03-2017 IPR002933 Peptidase M20 GO:0008152|GO:0016787 TK78_RS03815 04853c97de5eee5c5bd22825a3c9e0d8 514 Pfam PF00512 His Kinase A (phospho-acceptor) domain 288 352 5.0E-13 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS03815 04853c97de5eee5c5bd22825a3c9e0d8 514 Gene3D G3DSA:1.10.287.130 279 340 1.3E-13 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS03815 04853c97de5eee5c5bd22825a3c9e0d8 514 SMART SM00304 226 278 1.9E-15 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS03815 04853c97de5eee5c5bd22825a3c9e0d8 514 SUPERFAMILY SSF47384 273 352 1.49E-14 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS03815 04853c97de5eee5c5bd22825a3c9e0d8 514 SMART SM00387 395 509 6.9E-30 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS03815 04853c97de5eee5c5bd22825a3c9e0d8 514 SUPERFAMILY SSF158472 226 275 2.48E-9 T 09-03-2017 TK78_RS03815 04853c97de5eee5c5bd22825a3c9e0d8 514 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 396 508 2.8E-17 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS03815 04853c97de5eee5c5bd22825a3c9e0d8 514 Pfam PF00672 HAMP domain 212 274 1.8E-15 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS03815 04853c97de5eee5c5bd22825a3c9e0d8 514 SMART SM00388 286 353 8.2E-15 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS03815 04853c97de5eee5c5bd22825a3c9e0d8 514 PRINTS PR00344 Bacterial sensor protein C-terminal signature 493 506 1.1E-14 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS03815 04853c97de5eee5c5bd22825a3c9e0d8 514 PRINTS PR00344 Bacterial sensor protein C-terminal signature 469 487 1.1E-14 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS03815 04853c97de5eee5c5bd22825a3c9e0d8 514 PRINTS PR00344 Bacterial sensor protein C-terminal signature 453 463 1.1E-14 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS03815 04853c97de5eee5c5bd22825a3c9e0d8 514 PRINTS PR00344 Bacterial sensor protein C-terminal signature 435 449 1.1E-14 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS03815 04853c97de5eee5c5bd22825a3c9e0d8 514 Gene3D G3DSA:3.30.565.10 341 510 1.4E-35 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS03815 04853c97de5eee5c5bd22825a3c9e0d8 514 SUPERFAMILY SSF55874 342 507 3.41E-35 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS04035 0fb172d29d936822e58db9efa5a5b121 776 Hamap MF_01463_B Protein translocase subunit SecD [secD]. 2 445 35.57 T 09-03-2017 IPR005791 Protein translocase subunit SecD GO:0006886|GO:0015450 TK78_RS04035 0fb172d29d936822e58db9efa5a5b121 776 PRINTS PR01755 Bacterial translocase SecF protein signature 600 614 8.1E-21 T 09-03-2017 IPR022645 Protein-export membrane protein SecD/SecF, bacterial TK78_RS04035 0fb172d29d936822e58db9efa5a5b121 776 PRINTS PR01755 Bacterial translocase SecF protein signature 648 666 8.1E-21 T 09-03-2017 IPR022645 Protein-export membrane protein SecD/SecF, bacterial TK78_RS04035 0fb172d29d936822e58db9efa5a5b121 776 PRINTS PR01755 Bacterial translocase SecF protein signature 491 506 8.1E-21 T 09-03-2017 IPR022645 Protein-export membrane protein SecD/SecF, bacterial TK78_RS04035 0fb172d29d936822e58db9efa5a5b121 776 PRINTS PR01755 Bacterial translocase SecF protein signature 680 695 8.1E-21 T 09-03-2017 IPR022645 Protein-export membrane protein SecD/SecF, bacterial TK78_RS04035 0fb172d29d936822e58db9efa5a5b121 776 Gene3D G3DSA:1.20.1640.10 573 744 1.5E-23 T 09-03-2017 TK78_RS04035 0fb172d29d936822e58db9efa5a5b121 776 Gene3D G3DSA:1.20.1640.10 239 435 1.1E-23 T 09-03-2017 TK78_RS04035 0fb172d29d936822e58db9efa5a5b121 776 Pfam PF07549 SecD/SecF GG Motif 28 47 1.2E-4 T 09-03-2017 IPR022646 Protein-export membrane protein SecD/SecF/SecDF, conserved site TK78_RS04035 0fb172d29d936822e58db9efa5a5b121 776 Pfam PF07549 SecD/SecF GG Motif 488 513 2.5E-5 T 09-03-2017 IPR022646 Protein-export membrane protein SecD/SecF/SecDF, conserved site TK78_RS04035 0fb172d29d936822e58db9efa5a5b121 776 TIGRFAM TIGR00916 2A0604s01: protein-export membrane protein, SecD/SecF family 204 424 1.8E-62 T 09-03-2017 IPR022645 Protein-export membrane protein SecD/SecF, bacterial TK78_RS04035 0fb172d29d936822e58db9efa5a5b121 776 TIGRFAM TIGR00916 2A0604s01: protein-export membrane protein, SecD/SecF family 546 729 8.2E-45 T 09-03-2017 IPR022645 Protein-export membrane protein SecD/SecF, bacterial TK78_RS04035 0fb172d29d936822e58db9efa5a5b121 776 TIGRFAM TIGR01129 secD: protein-export membrane protein SecD 30 430 6.9E-115 T 09-03-2017 IPR005791 Protein translocase subunit SecD GO:0006886|GO:0015450 TK78_RS04035 0fb172d29d936822e58db9efa5a5b121 776 TIGRFAM TIGR00966 3a0501s07: protein-export membrane protein SecF 493 732 7.4E-64 T 09-03-2017 IPR005665 Protein-export membrane protein SecF, bacterial GO:0006886|GO:0015450 TK78_RS04035 0fb172d29d936822e58db9efa5a5b121 776 SUPERFAMILY SSF82866 574 733 7.06E-29 T 09-03-2017 TK78_RS04035 0fb172d29d936822e58db9efa5a5b121 776 Pfam PF02355 Protein export membrane protein 262 431 2.9E-17 T 09-03-2017 IPR022813 Protein-export membrane protein SecD/SecF, archaeal and bacterial TK78_RS04035 0fb172d29d936822e58db9efa5a5b121 776 Pfam PF02355 Protein export membrane protein 558 739 1.0E-61 T 09-03-2017 IPR022813 Protein-export membrane protein SecD/SecF, archaeal and bacterial TK78_RS04035 0fb172d29d936822e58db9efa5a5b121 776 SUPERFAMILY SSF82866 239 433 5.36E-34 T 09-03-2017 TK78_RS04035 0fb172d29d936822e58db9efa5a5b121 776 Hamap MF_01464_B Protein-export membrane protein SecF [secF]. 467 743 25.044 T 09-03-2017 IPR005665 Protein-export membrane protein SecF, bacterial GO:0006886|GO:0015450 TK78_RS30395 6c107975bf8f4843d936903010e99f5c 488 Pfam PF00478 IMP dehydrogenase / GMP reductase domain 21 482 2.5E-102 T 09-03-2017 IPR001093 IMP dehydrogenase/GMP reductase GO:0003824|GO:0055114 TK78_RS30395 6c107975bf8f4843d936903010e99f5c 488 SMART SM01240 19 483 1.2E-191 T 09-03-2017 TK78_RS30395 6c107975bf8f4843d936903010e99f5c 488 SUPERFAMILY SSF54631 102 212 1.26E-20 T 09-03-2017 TK78_RS30395 6c107975bf8f4843d936903010e99f5c 488 PIRSF PIRSF000130 11 488 5.3E-146 T 09-03-2017 IPR005990 Inosine-5'-monophosphate dehydrogenase GO:0003938|GO:0006164|GO:0055114 KEGG: 00053+1.1.1.20|KEGG: 00230+1.1.1.205|KEGG: 00983+1.1.1.205|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-7221|Reactome: R-HSA-73817 TK78_RS30395 6c107975bf8f4843d936903010e99f5c 488 Gene3D G3DSA:3.20.20.70 20 483 6.7E-136 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS30395 6c107975bf8f4843d936903010e99f5c 488 SUPERFAMILY SSF51412 20 101 2.09E-90 T 09-03-2017 TK78_RS30395 6c107975bf8f4843d936903010e99f5c 488 SUPERFAMILY SSF51412 223 482 2.09E-90 T 09-03-2017 TK78_RS30395 6c107975bf8f4843d936903010e99f5c 488 TIGRFAM TIGR01303 IMP_DH_rel_1: IMP dehydrogenase family protein 12 485 4.3E-273 T 09-03-2017 IPR005991 IMP dehydrogenase-related 1 TK78_RS30395 6c107975bf8f4843d936903010e99f5c 488 Pfam PF00571 CBS domain 159 211 1.8E-5 T 09-03-2017 IPR000644 CBS domain TK78_RS30395 6c107975bf8f4843d936903010e99f5c 488 Pfam PF00571 CBS domain 107 149 2.4E-4 T 09-03-2017 IPR000644 CBS domain TK78_RS30395 6c107975bf8f4843d936903010e99f5c 488 SMART SM00116 106 154 3.1 T 09-03-2017 IPR000644 CBS domain TK78_RS30395 6c107975bf8f4843d936903010e99f5c 488 SMART SM00116 165 213 0.29 T 09-03-2017 IPR000644 CBS domain TK78_RS11685 77ff037bd2febd16ae76d046cada4002 370 Gene3D G3DSA:3.40.1190.20 13 342 7.2E-99 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS11685 77ff037bd2febd16ae76d046cada4002 370 Pfam PF00294 pfkB family carbohydrate kinase 15 329 1.0E-48 T 09-03-2017 IPR011611 Carbohydrate kinase PfkB TK78_RS11685 77ff037bd2febd16ae76d046cada4002 370 SUPERFAMILY SSF53613 14 337 1.51E-65 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS23085 312c33d7c9bc5aabda29e292ebc40dde 300 SMART SM00062 54 284 3.8E-31 T 09-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF TK78_RS23085 312c33d7c9bc5aabda29e292ebc40dde 300 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3 55 280 2.0E-40 T 09-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF TK78_RS23085 312c33d7c9bc5aabda29e292ebc40dde 300 TIGRFAM TIGR02995 ectoine_ehuB: ectoine/hydroxyectoine ABC transporter solute-binding protein EhuB 37 298 2.1E-65 T 09-03-2017 IPR014337 Ectoine/Hydroxyectoine-binding protein EhuB GO:0005886|GO:0033294|GO:0051470|GO:0051471 TK78_RS23085 312c33d7c9bc5aabda29e292ebc40dde 300 Gene3D G3DSA:3.40.190.10 238 269 5.8E-21 T 09-03-2017 TK78_RS23085 312c33d7c9bc5aabda29e292ebc40dde 300 Gene3D G3DSA:3.40.190.10 50 128 5.8E-21 T 09-03-2017 TK78_RS23085 312c33d7c9bc5aabda29e292ebc40dde 300 SUPERFAMILY SSF53850 55 280 1.03E-39 T 09-03-2017 TK78_RS23085 312c33d7c9bc5aabda29e292ebc40dde 300 TIGRFAM TIGR01409 TAT_signal_seq: Tat (twin-arginine translocation) pathway signal sequence 7 25 0.0016 T 09-03-2017 IPR019546 Twin-arginine translocation pathway, signal sequence, bacterial/archaeal TK78_RS23085 312c33d7c9bc5aabda29e292ebc40dde 300 Gene3D G3DSA:3.40.190.10 129 228 8.0E-11 T 09-03-2017 TK78_RS25365 d3df74c2a4cfbb9792b0fb7541f57876 519 SUPERFAMILY SSF56801 17 519 4.06E-127 T 09-03-2017 TK78_RS25365 d3df74c2a4cfbb9792b0fb7541f57876 519 Gene3D G3DSA:2.30.38.10 344 419 9.3E-28 T 09-03-2017 TK78_RS25365 d3df74c2a4cfbb9792b0fb7541f57876 519 Pfam PF00501 AMP-binding enzyme 17 425 1.8E-83 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS25365 d3df74c2a4cfbb9792b0fb7541f57876 519 ProSitePatterns PS00455 Putative AMP-binding domain signature. 171 182 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS25365 d3df74c2a4cfbb9792b0fb7541f57876 519 Gene3D G3DSA:3.30.300.30 422 519 5.6E-30 T 09-03-2017 TK78_RS25365 d3df74c2a4cfbb9792b0fb7541f57876 519 Gene3D G3DSA:3.40.50.980 17 175 4.5E-26 T 09-03-2017 TK78_RS25365 d3df74c2a4cfbb9792b0fb7541f57876 519 Gene3D G3DSA:3.40.50.980 176 343 2.4E-32 T 09-03-2017 TK78_RS25365 d3df74c2a4cfbb9792b0fb7541f57876 519 Pfam PF13193 AMP-binding enzyme C-terminal domain 435 511 4.0E-19 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS26240 8136ba025852a04cb491bfdda4ca1958 341 Gene3D G3DSA:3.60.10.10 126 277 6.7E-11 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS26240 8136ba025852a04cb491bfdda4ca1958 341 SUPERFAMILY SSF56219 125 340 6.81E-27 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS26240 8136ba025852a04cb491bfdda4ca1958 341 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 130 332 1.2E-18 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS23110 d5eeb727bae27a5e6bdf57c8f14eb27d 654 Pfam PF08448 PAS fold 81 192 2.2E-7 T 09-03-2017 IPR013656 PAS fold-4 TK78_RS23110 d5eeb727bae27a5e6bdf57c8f14eb27d 654 Pfam PF00990 Diguanylate cyclase, GGDEF domain 202 373 6.5E-38 T 09-03-2017 IPR000160 GGDEF domain TK78_RS23110 d5eeb727bae27a5e6bdf57c8f14eb27d 654 Gene3D G3DSA:3.30.450.20 72 190 1.7E-14 T 09-03-2017 TK78_RS23110 d5eeb727bae27a5e6bdf57c8f14eb27d 654 SMART SM00052 388 642 6.3E-99 T 09-03-2017 IPR001633 EAL domain TK78_RS23110 d5eeb727bae27a5e6bdf57c8f14eb27d 654 SUPERFAMILY SSF55073 207 380 2.04E-37 T 09-03-2017 IPR029787 Nucleotide cyclase TK78_RS23110 d5eeb727bae27a5e6bdf57c8f14eb27d 654 Gene3D G3DSA:3.30.70.270 202 383 6.0E-49 T 09-03-2017 TK78_RS23110 d5eeb727bae27a5e6bdf57c8f14eb27d 654 Gene3D G3DSA:3.20.20.450 392 647 1.3E-103 T 09-03-2017 IPR001633 EAL domain TK78_RS23110 d5eeb727bae27a5e6bdf57c8f14eb27d 654 TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain 198 376 3.4E-30 T 09-03-2017 IPR000160 GGDEF domain TK78_RS23110 d5eeb727bae27a5e6bdf57c8f14eb27d 654 SMART SM00267 190 378 3.0E-47 T 09-03-2017 IPR000160 GGDEF domain TK78_RS23110 d5eeb727bae27a5e6bdf57c8f14eb27d 654 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 73 197 1.2E-13 T 09-03-2017 IPR000014 PAS domain TK78_RS23110 d5eeb727bae27a5e6bdf57c8f14eb27d 654 SUPERFAMILY SSF141868 395 647 7.59E-79 T 09-03-2017 IPR001633 EAL domain TK78_RS23110 d5eeb727bae27a5e6bdf57c8f14eb27d 654 SUPERFAMILY SSF55785 89 198 8.38E-15 T 09-03-2017 IPR000014 PAS domain TK78_RS23110 d5eeb727bae27a5e6bdf57c8f14eb27d 654 Pfam PF00563 EAL domain 395 636 1.3E-65 T 09-03-2017 IPR001633 EAL domain TK78_RS09265 0e1e7e9f4222569a31e409b53e6cb825 216 SUPERFAMILY SSF52172 8 140 3.27E-33 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS09265 0e1e7e9f4222569a31e409b53e6cb825 216 Gene3D G3DSA:3.40.50.2300 3 127 2.3E-35 T 09-03-2017 TK78_RS09265 0e1e7e9f4222569a31e409b53e6cb825 216 Pfam PF00072 Response regulator receiver domain 11 122 7.2E-26 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS09265 0e1e7e9f4222569a31e409b53e6cb825 216 SMART SM00421 152 209 1.7E-25 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS09265 0e1e7e9f4222569a31e409b53e6cb825 216 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 155 169 3.8E-15 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS09265 0e1e7e9f4222569a31e409b53e6cb825 216 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 169 185 3.8E-15 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS09265 0e1e7e9f4222569a31e409b53e6cb825 216 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 185 197 3.8E-15 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS09265 0e1e7e9f4222569a31e409b53e6cb825 216 SUPERFAMILY SSF46894 143 215 3.23E-22 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS09265 0e1e7e9f4222569a31e409b53e6cb825 216 SMART SM00448 9 122 4.6E-30 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS09265 0e1e7e9f4222569a31e409b53e6cb825 216 Gene3D G3DSA:1.10.10.10 128 215 3.5E-30 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS09265 0e1e7e9f4222569a31e409b53e6cb825 216 Pfam PF00196 Bacterial regulatory proteins, luxR family 154 207 1.3E-20 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS09265 0e1e7e9f4222569a31e409b53e6cb825 216 ProSitePatterns PS00622 LuxR-type HTH domain signature. 169 196 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS28365 0f134a40eded75c004cfc050f6711756 512 PRINTS PR00723 Subtilisin serine protease family (S8) signature 175 194 2.8E-20 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS28365 0f134a40eded75c004cfc050f6711756 512 PRINTS PR00723 Subtilisin serine protease family (S8) signature 223 236 2.8E-20 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS28365 0f134a40eded75c004cfc050f6711756 512 PRINTS PR00723 Subtilisin serine protease family (S8) signature 432 448 2.8E-20 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS28365 0f134a40eded75c004cfc050f6711756 512 ProSitePatterns PS00137 Serine proteases, subtilase family, histidine active site. 227 237 - T 09-03-2017 IPR022398 Peptidase S8, subtilisin, His-active site TK78_RS28365 0f134a40eded75c004cfc050f6711756 512 SUPERFAMILY SSF52743 361 511 2.62E-76 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS28365 0f134a40eded75c004cfc050f6711756 512 SUPERFAMILY SSF52743 155 334 2.62E-76 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS28365 0f134a40eded75c004cfc050f6711756 512 Gene3D G3DSA:3.40.50.200 149 511 1.2E-80 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS28365 0f134a40eded75c004cfc050f6711756 512 ProSitePatterns PS00138 Serine proteases, subtilase family, serine active site. 433 443 - T 09-03-2017 IPR023828 Peptidase S8, subtilisin, Ser-active site TK78_RS28365 0f134a40eded75c004cfc050f6711756 512 Pfam PF00082 Subtilase family 176 469 5.0E-46 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS28365 0f134a40eded75c004cfc050f6711756 512 ProSitePatterns PS00136 Serine proteases, subtilase family, aspartic acid active site. 180 191 - T 09-03-2017 IPR023827 Peptidase S8, subtilisin, Asp-active site TK78_RS13145 c7a72134b74ccaeff76606d235be164d 93 TIGRFAM TIGR01050 rpsS_bact: ribosomal protein uS19 1 92 8.8E-46 T 09-03-2017 IPR005732 Ribosomal protein S19, bacterial-type GO:0003735|GO:0006412|GO:0015935 TK78_RS13145 c7a72134b74ccaeff76606d235be164d 93 Hamap MF_00531 30S ribosomal protein S19 [rpsS]. 1 89 24.641 T 09-03-2017 IPR002222 Ribosomal protein S19/S15 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13145 c7a72134b74ccaeff76606d235be164d 93 PRINTS PR00975 Ribosomal protein S19 family signature 53 65 8.2E-24 T 09-03-2017 IPR002222 Ribosomal protein S19/S15 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13145 c7a72134b74ccaeff76606d235be164d 93 PRINTS PR00975 Ribosomal protein S19 family signature 33 52 8.2E-24 T 09-03-2017 IPR002222 Ribosomal protein S19/S15 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13145 c7a72134b74ccaeff76606d235be164d 93 PRINTS PR00975 Ribosomal protein S19 family signature 65 80 8.2E-24 T 09-03-2017 IPR002222 Ribosomal protein S19/S15 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13145 c7a72134b74ccaeff76606d235be164d 93 SUPERFAMILY SSF54570 3 84 1.31E-34 T 09-03-2017 IPR023575 Ribosomal protein S19, superfamily GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13145 c7a72134b74ccaeff76606d235be164d 93 PIRSF PIRSF002144 1 93 4.3E-31 T 09-03-2017 IPR002222 Ribosomal protein S19/S15 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13145 c7a72134b74ccaeff76606d235be164d 93 Gene3D G3DSA:3.30.860.10 1 92 4.5E-40 T 09-03-2017 IPR023575 Ribosomal protein S19, superfamily GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13145 c7a72134b74ccaeff76606d235be164d 93 ProSitePatterns PS00323 Ribosomal protein S19 signature. 53 77 - T 09-03-2017 IPR020934 Ribosomal protein S19 conserved site GO:0003723 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13145 c7a72134b74ccaeff76606d235be164d 93 Pfam PF00203 Ribosomal protein S19 3 83 6.6E-36 T 09-03-2017 IPR002222 Ribosomal protein S19/S15 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS30500 0a7fafe79e8216edbc1a16ca84fd2763 369 Gene3D G3DSA:3.10.580.10 224 333 1.4E-14 T 09-03-2017 TK78_RS30500 0a7fafe79e8216edbc1a16ca84fd2763 369 Pfam PF01595 Domain of unknown function DUF21 7 199 9.0E-41 T 09-03-2017 IPR002550 Domain of unknown function DUF21 TK78_RS30500 0a7fafe79e8216edbc1a16ca84fd2763 369 SMART SM00116 225 274 0.035 T 09-03-2017 IPR000644 CBS domain TK78_RS30500 0a7fafe79e8216edbc1a16ca84fd2763 369 SMART SM00116 286 334 0.61 T 09-03-2017 IPR000644 CBS domain TK78_RS30500 0a7fafe79e8216edbc1a16ca84fd2763 369 SUPERFAMILY SSF54631 206 343 2.91E-23 T 09-03-2017 TK78_RS30500 0a7fafe79e8216edbc1a16ca84fd2763 369 Pfam PF00571 CBS domain 285 334 4.1E-5 T 09-03-2017 IPR000644 CBS domain TK78_RS30500 0a7fafe79e8216edbc1a16ca84fd2763 369 Pfam PF00571 CBS domain 224 271 0.0037 T 09-03-2017 IPR000644 CBS domain TK78_RS29065 76d4d7d2a459c59d28c28df3b249b9bd 160 Gene3D G3DSA:3.40.630.30 34 148 8.7E-12 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS29065 76d4d7d2a459c59d28c28df3b249b9bd 160 Pfam PF00583 Acetyltransferase (GNAT) family 54 141 3.8E-8 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS29065 76d4d7d2a459c59d28c28df3b249b9bd 160 Gene3D G3DSA:1.10.287.900 7 33 2.9E-7 T 09-03-2017 IPR027455 Spermine/spermidine acetyltransferase, N-terminal domain KEGG: 00330+2.3.1.57|MetaCyc: PWY-0|MetaCyc: PWY-6117 TK78_RS29065 76d4d7d2a459c59d28c28df3b249b9bd 160 SUPERFAMILY SSF55729 7 148 2.16E-13 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS27350 7a0d345b89068b52cc43102e68859f64 428 SUPERFAMILY SSF53686 15 402 6.29E-145 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS27350 7a0d345b89068b52cc43102e68859f64 428 Gene3D G3DSA:3.40.50.1100 190 404 4.7E-98 T 09-03-2017 TK78_RS27350 7a0d345b89068b52cc43102e68859f64 428 Gene3D G3DSA:3.40.50.1100 111 189 7.6E-23 T 09-03-2017 TK78_RS27350 7a0d345b89068b52cc43102e68859f64 428 PIRSF PIRSF001413 10 407 1.7E-157 T 09-03-2017 IPR023026 Tryptophan synthase beta chain/beta chain-like GO:0000162|GO:0004834 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 TK78_RS27350 7a0d345b89068b52cc43102e68859f64 428 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 64 390 2.7E-52 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS27350 7a0d345b89068b52cc43102e68859f64 428 Hamap MF_00133 Tryptophan synthase beta chain [trpB]. 14 403 51.16 T 09-03-2017 IPR023026 Tryptophan synthase beta chain/beta chain-like GO:0000162|GO:0004834 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 TK78_RS27350 7a0d345b89068b52cc43102e68859f64 428 TIGRFAM TIGR00263 trpB: tryptophan synthase, beta subunit 19 401 1.2E-182 T 09-03-2017 IPR006654 Tryptophan synthase, beta chain GO:0004834|GO:0006568 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 TK78_RS27350 7a0d345b89068b52cc43102e68859f64 428 ProSitePatterns PS00168 Tryptophan synthase beta chain pyridoxal-phosphate attachment site. 93 107 - T 09-03-2017 IPR006653 Tryptophan synthase, beta chain, conserved site GO:0004834|GO:0006568 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 TK78_RS09375 0f62e886e56fc94a18128fd56d4e046f 566 Pfam PF00989 PAS fold 217 312 4.9E-6 T 09-03-2017 IPR013767 PAS fold GO:0006355 TK78_RS09375 0f62e886e56fc94a18128fd56d4e046f 566 Pfam PF17203 Single cache domain 3 40 171 2.9E-30 T 09-03-2017 IPR033463 Single cache domain 3 TK78_RS09375 0f62e886e56fc94a18128fd56d4e046f 566 SUPERFAMILY SSF55890 330 391 3.92E-5 T 09-03-2017 IPR016120 Signal transduction histidine kinase, sporulation regulator SpoOB GO:0000155|GO:0000160|GO:0016772 TK78_RS09375 0f62e886e56fc94a18128fd56d4e046f 566 SUPERFAMILY SSF103190 41 171 1.88E-36 T 09-03-2017 IPR029151 Periplasmic sensor domain-like TK78_RS09375 0f62e886e56fc94a18128fd56d4e046f 566 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 424 548 1.0E-15 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09375 0f62e886e56fc94a18128fd56d4e046f 566 SMART SM00387 421 550 2.3E-23 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09375 0f62e886e56fc94a18128fd56d4e046f 566 PRINTS PR00344 Bacterial sensor protein C-terminal signature 481 495 2.1E-11 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS09375 0f62e886e56fc94a18128fd56d4e046f 566 PRINTS PR00344 Bacterial sensor protein C-terminal signature 510 528 2.1E-11 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS09375 0f62e886e56fc94a18128fd56d4e046f 566 PRINTS PR00344 Bacterial sensor protein C-terminal signature 534 547 2.1E-11 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS09375 0f62e886e56fc94a18128fd56d4e046f 566 SUPERFAMILY SSF55874 416 548 4.98E-27 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09375 0f62e886e56fc94a18128fd56d4e046f 566 Gene3D G3DSA:3.30.565.10 385 550 1.3E-29 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09375 0f62e886e56fc94a18128fd56d4e046f 566 Gene3D G3DSA:1.10.287.130 311 363 1.3E-10 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS09375 0f62e886e56fc94a18128fd56d4e046f 566 Gene3D G3DSA:3.30.450.20 213 310 5.5E-9 T 09-03-2017 TK78_RS09375 0f62e886e56fc94a18128fd56d4e046f 566 SUPERFAMILY SSF55785 207 312 6.47E-8 T 09-03-2017 IPR000014 PAS domain TK78_RS09375 0f62e886e56fc94a18128fd56d4e046f 566 Gene3D G3DSA:3.30.450.20 36 172 2.2E-44 T 09-03-2017 TK78_RS09675 3cd09ea0c9bd50b8d9e30cdba0c1fbd8 305 Gene3D G3DSA:3.40.1380.10 64 197 7.2E-38 T 09-03-2017 TK78_RS09675 3cd09ea0c9bd50b8d9e30cdba0c1fbd8 305 Gene3D G3DSA:1.10.287.80 245 291 4.9E-27 T 09-03-2017 TK78_RS09675 3cd09ea0c9bd50b8d9e30cdba0c1fbd8 305 Gene3D G3DSA:1.10.287.80 211 244 6.6E-30 T 09-03-2017 TK78_RS09675 3cd09ea0c9bd50b8d9e30cdba0c1fbd8 305 Gene3D G3DSA:1.10.287.80 20 61 6.6E-30 T 09-03-2017 TK78_RS09675 3cd09ea0c9bd50b8d9e30cdba0c1fbd8 305 SUPERFAMILY SSF52943 3 296 2.75E-79 T 09-03-2017 IPR023633 ATPase, F1 complex, gamma subunit domain Reactome: R-HSA-163210 TK78_RS09675 3cd09ea0c9bd50b8d9e30cdba0c1fbd8 305 TIGRFAM TIGR01146 ATPsyn_F1gamma: ATP synthase F1, gamma subunit 3 296 3.1E-92 T 09-03-2017 IPR000131 ATPase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 TK78_RS09675 3cd09ea0c9bd50b8d9e30cdba0c1fbd8 305 Pfam PF00231 ATP synthase 5 296 1.5E-84 T 09-03-2017 IPR000131 ATPase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 TK78_RS09675 3cd09ea0c9bd50b8d9e30cdba0c1fbd8 305 PRINTS PR00126 ATP synthase gamma subunit signature 74 93 2.4E-31 T 09-03-2017 IPR000131 ATPase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 TK78_RS09675 3cd09ea0c9bd50b8d9e30cdba0c1fbd8 305 PRINTS PR00126 ATP synthase gamma subunit signature 274 295 2.4E-31 T 09-03-2017 IPR000131 ATPase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 TK78_RS09675 3cd09ea0c9bd50b8d9e30cdba0c1fbd8 305 PRINTS PR00126 ATP synthase gamma subunit signature 243 262 2.4E-31 T 09-03-2017 IPR000131 ATPase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 TK78_RS09675 3cd09ea0c9bd50b8d9e30cdba0c1fbd8 305 PRINTS PR00126 ATP synthase gamma subunit signature 171 188 2.4E-31 T 09-03-2017 IPR000131 ATPase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 TK78_RS09675 3cd09ea0c9bd50b8d9e30cdba0c1fbd8 305 Hamap MF_00815 ATP synthase gamma chain [atpG]. 2 296 33.369 T 09-03-2017 IPR000131 ATPase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 TK78_RS09675 3cd09ea0c9bd50b8d9e30cdba0c1fbd8 305 ProSitePatterns PS00153 ATP synthase gamma subunit signature. 282 295 - T 09-03-2017 IPR023632 ATPase, F1 complex, gamma subunit conserved site Reactome: R-HSA-163210 TK78_RS19570 c9bda276d948a33b26999a6c30954760 326 Gene3D G3DSA:3.90.550.10 72 312 4.0E-45 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS19570 c9bda276d948a33b26999a6c30954760 326 SUPERFAMILY SSF53448 71 314 1.3E-55 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS19570 c9bda276d948a33b26999a6c30954760 326 Pfam PF13641 Glycosyltransferase like family 2 69 294 7.6E-39 T 09-03-2017 TK78_RS34125 c47630c6d8ea4293eff8dac3438e58a3 541 Pfam PF00501 AMP-binding enzyme 9 439 1.7E-60 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS34125 c47630c6d8ea4293eff8dac3438e58a3 541 Gene3D G3DSA:3.30.300.30 437 534 5.0E-27 T 09-03-2017 TK78_RS34125 c47630c6d8ea4293eff8dac3438e58a3 541 Gene3D G3DSA:3.40.50.980 4 181 4.8E-35 T 09-03-2017 TK78_RS34125 c47630c6d8ea4293eff8dac3438e58a3 541 SUPERFAMILY SSF56801 4 537 1.28E-112 T 09-03-2017 TK78_RS34125 c47630c6d8ea4293eff8dac3438e58a3 541 Pfam PF13193 AMP-binding enzyme C-terminal domain 449 525 4.7E-16 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS34125 c47630c6d8ea4293eff8dac3438e58a3 541 ProSitePatterns PS00455 Putative AMP-binding domain signature. 176 187 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS34125 c47630c6d8ea4293eff8dac3438e58a3 541 Gene3D G3DSA:2.30.38.10 362 433 2.9E-12 T 09-03-2017 TK78_RS34125 c47630c6d8ea4293eff8dac3438e58a3 541 Gene3D G3DSA:3.40.50.980 182 349 3.0E-19 T 09-03-2017 TK78_RS32820 f927eca96ab1e5ca158b036bdd1c3e8e 194 SUPERFAMILY SSF46689 5 83 5.64E-16 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS32820 f927eca96ab1e5ca158b036bdd1c3e8e 194 Pfam PF00440 Bacterial regulatory proteins, tetR family 12 58 1.6E-11 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS32820 f927eca96ab1e5ca158b036bdd1c3e8e 194 Gene3D G3DSA:1.10.357.10 7 187 1.1E-31 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS32820 f927eca96ab1e5ca158b036bdd1c3e8e 194 SUPERFAMILY SSF48498 79 187 5.01E-18 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS32820 f927eca96ab1e5ca158b036bdd1c3e8e 194 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 12 25 9.4E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS32820 f927eca96ab1e5ca158b036bdd1c3e8e 194 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 33 56 9.4E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS25235 7ff91f61664cc80f481b84572bf9562c 449 Gene3D G3DSA:1.10.3210.10 33 239 2.3E-63 T 09-03-2017 IPR006674 HD domain TK78_RS25235 7ff91f61664cc80f481b84572bf9562c 449 TIGRFAM TIGR01353 dGTP_triPase: putative dGTPase 46 445 8.2E-72 T 09-03-2017 IPR006261 Deoxyguanosinetriphosphate triphosphohydrolase GO:0000287|GO:0008832|GO:0046039 TK78_RS25235 7ff91f61664cc80f481b84572bf9562c 449 SUPERFAMILY SSF109604 224 415 9.65E-55 T 09-03-2017 TK78_RS25235 7ff91f61664cc80f481b84572bf9562c 449 SUPERFAMILY SSF109604 40 193 9.65E-55 T 09-03-2017 TK78_RS25235 7ff91f61664cc80f481b84572bf9562c 449 SMART SM00471 84 253 5.0E-11 T 09-03-2017 IPR003607 HD/PDEase domain TK78_RS25235 7ff91f61664cc80f481b84572bf9562c 449 Gene3D G3DSA:1.10.3410.10 240 372 9.9E-21 T 09-03-2017 IPR023293 Deoxyguanosinetriphosphate triphosphohydrolase, central domain TK78_RS25235 7ff91f61664cc80f481b84572bf9562c 449 Pfam PF13286 Phosphohydrolase-associated domain 352 442 6.3E-18 T 09-03-2017 IPR026875 Phosphohydrolase-associated domain TK78_RS25235 7ff91f61664cc80f481b84572bf9562c 449 Pfam PF01966 HD domain 88 242 4.3E-14 T 09-03-2017 IPR006674 HD domain TK78_RS25235 7ff91f61664cc80f481b84572bf9562c 449 Hamap MF_01212 Deoxyguanosinetriphosphate triphosphohydrolase-like protein. 28 445 30.009 T 09-03-2017 IPR023023 Deoxyguanosinetriphosphate triphosphohydrolase, type 2 TK78_RS13275 2f3cb2ca4ffc11e7c023843a64be4808 408 SUPERFAMILY SSF53383 12 405 2.18E-113 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS13275 2f3cb2ca4ffc11e7c023843a64be4808 408 Pfam PF00155 Aminotransferase class I and II 40 394 2.5E-72 T 09-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TK78_RS13275 2f3cb2ca4ffc11e7c023843a64be4808 408 Gene3D G3DSA:3.90.1150.10 283 405 4.6E-35 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS13275 2f3cb2ca4ffc11e7c023843a64be4808 408 Gene3D G3DSA:3.40.640.10 52 282 2.3E-77 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS13275 2f3cb2ca4ffc11e7c023843a64be4808 408 ProSitePatterns PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 244 257 - T 09-03-2017 IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding site GO:0003824|GO:0009058|GO:0030170 TK78_RS14500 57fe7197254041580a93dd21d6cad25a 266 Gene3D G3DSA:3.40.50.1820 7 261 6.9E-25 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS14500 57fe7197254041580a93dd21d6cad25a 266 SUPERFAMILY SSF53474 8 260 2.65E-25 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS14500 57fe7197254041580a93dd21d6cad25a 266 Pfam PF12697 Alpha/beta hydrolase family 30 257 7.8E-14 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS33850 4c41946473739519ff5afa0792e64f50 735 SUPERFAMILY SSF81345 405 727 2.62E-58 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS33850 4c41946473739519ff5afa0792e64f50 735 SUPERFAMILY SSF81345 19 346 6.02E-67 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS33850 4c41946473739519ff5afa0792e64f50 735 Pfam PF01032 FecCD transport family 422 727 1.6E-72 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS33850 4c41946473739519ff5afa0792e64f50 735 Pfam PF01032 FecCD transport family 34 346 4.6E-81 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS33850 4c41946473739519ff5afa0792e64f50 735 Gene3D G3DSA:1.10.3470.10 20 349 1.6E-86 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS33850 4c41946473739519ff5afa0792e64f50 735 Gene3D G3DSA:1.10.3470.10 409 730 2.4E-73 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS23080 b60e7351dff848a413b4edeeae381098 243 SUPERFAMILY SSF161098 14 201 1.07E-38 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS23080 b60e7351dff848a413b4edeeae381098 243 TIGRFAM TIGR03004 ectoine_ehuC: ectoine/hydroxyectoine ABC transporter, permease protein EhuC 12 217 3.9E-66 T 09-03-2017 IPR014342 Ectoine/hydroxyectoine ABC transporter, permease protein EhuC TK78_RS23080 b60e7351dff848a413b4edeeae381098 243 Gene3D G3DSA:1.10.3720.10 12 217 2.0E-39 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS23080 b60e7351dff848a413b4edeeae381098 243 TIGRFAM TIGR01726 HEQRo_perm_3TM: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family 12 110 9.1E-23 T 09-03-2017 IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain GO:0005215|GO:0006810|GO:0016021 TK78_RS23080 b60e7351dff848a413b4edeeae381098 243 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 38 215 1.9E-15 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS13345 45821e0c4b46ecb1c39bccd3f89c27f1 162 Pfam PF04461 Protein of unknown function (DUF520) 4 162 6.9E-61 T 09-03-2017 IPR007551 Protein of unknown function DUF520 TK78_RS13345 45821e0c4b46ecb1c39bccd3f89c27f1 162 SUPERFAMILY SSF89963 90 162 4.45E-23 T 09-03-2017 IPR007551 Protein of unknown function DUF520 TK78_RS13345 45821e0c4b46ecb1c39bccd3f89c27f1 162 Gene3D G3DSA:3.30.70.990 11 96 9.5E-31 T 09-03-2017 TK78_RS13345 45821e0c4b46ecb1c39bccd3f89c27f1 162 Hamap MF_00632 UPF0234 protein YajQ [yajQ]. 3 162 25.557 T 09-03-2017 IPR007551 Protein of unknown function DUF520 TK78_RS13345 45821e0c4b46ecb1c39bccd3f89c27f1 162 Gene3D G3DSA:3.30.70.860 97 162 7.3E-29 T 09-03-2017 TK78_RS13345 45821e0c4b46ecb1c39bccd3f89c27f1 162 SUPERFAMILY SSF89963 5 87 8.11E-29 T 09-03-2017 IPR007551 Protein of unknown function DUF520 TK78_RS12350 7e55e62ceb4625ec285c52e837adc9dd 160 Pfam PF01127 Succinate dehydrogenase/Fumarate reductase transmembrane subunit 36 143 1.1E-16 T 09-03-2017 IPR000701 Succinate dehydrogenase/Fumarate reductase, transmembrane subunit GO:0016627 Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS12350 7e55e62ceb4625ec285c52e837adc9dd 160 SUPERFAMILY SSF81343 35 157 8.72E-34 T 09-03-2017 TK78_RS12350 7e55e62ceb4625ec285c52e837adc9dd 160 Gene3D G3DSA:1.20.950.10 33 159 1.4E-39 T 09-03-2017 TK78_RS33310 e35b37272399e06d473a0f9e348a6a71 418 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 164 180 - T 09-03-2017 IPR018201 Beta-ketoacyl synthase, active site TK78_RS33310 e35b37272399e06d473a0f9e348a6a71 418 Gene3D G3DSA:3.40.47.10 17 268 1.2E-62 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS33310 e35b37272399e06d473a0f9e348a6a71 418 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 16 254 3.8E-53 T 09-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal TK78_RS33310 e35b37272399e06d473a0f9e348a6a71 418 Gene3D G3DSA:3.40.47.10 273 417 1.1E-52 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS33310 e35b37272399e06d473a0f9e348a6a71 418 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 265 375 5.7E-32 T 09-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal TK78_RS33310 e35b37272399e06d473a0f9e348a6a71 418 SMART SM00825 Beta-ketoacyl synthase 17 409 1.4E-13 T 09-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TK78_RS33310 e35b37272399e06d473a0f9e348a6a71 418 SUPERFAMILY SSF53901 13 115 1.15E-67 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS33310 e35b37272399e06d473a0f9e348a6a71 418 SUPERFAMILY SSF53901 146 412 1.15E-67 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS12515 9b18cbbdedcb7c9cd3430ead7ca56a83 294 SUPERFAMILY SSF51735 1 128 6.76E-35 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS12515 9b18cbbdedcb7c9cd3430ead7ca56a83 294 Gene3D G3DSA:3.40.50.261 126 291 1.2E-65 T 09-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 TK78_RS12515 9b18cbbdedcb7c9cd3430ead7ca56a83 294 PRINTS PR01798 Succinyl-CoA synthase signature 212 225 6.3E-34 T 09-03-2017 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 TK78_RS12515 9b18cbbdedcb7c9cd3430ead7ca56a83 294 PRINTS PR01798 Succinyl-CoA synthase signature 244 261 6.3E-34 T 09-03-2017 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 TK78_RS12515 9b18cbbdedcb7c9cd3430ead7ca56a83 294 PRINTS PR01798 Succinyl-CoA synthase signature 86 103 6.3E-34 T 09-03-2017 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 TK78_RS12515 9b18cbbdedcb7c9cd3430ead7ca56a83 294 PRINTS PR01798 Succinyl-CoA synthase signature 181 199 6.3E-34 T 09-03-2017 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 TK78_RS12515 9b18cbbdedcb7c9cd3430ead7ca56a83 294 SUPERFAMILY SSF52210 129 289 1.44E-46 T 09-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 TK78_RS12515 9b18cbbdedcb7c9cd3430ead7ca56a83 294 PIRSF PIRSF001553 1 294 5.5E-113 T 09-03-2017 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 TK78_RS12515 9b18cbbdedcb7c9cd3430ead7ca56a83 294 Pfam PF02629 CoA binding domain 6 103 3.7E-25 T 09-03-2017 IPR003781 CoA-binding GO:0048037 TK78_RS12515 9b18cbbdedcb7c9cd3430ead7ca56a83 294 ProSitePatterns PS01216 ATP-citrate lyase / succinyl-CoA ligases family signature 1. 158 185 - T 09-03-2017 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 TK78_RS12515 9b18cbbdedcb7c9cd3430ead7ca56a83 294 TIGRFAM TIGR01019 sucCoAalpha: succinate-CoA ligase, alpha subunit 3 292 1.1E-125 T 09-03-2017 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 TK78_RS12515 9b18cbbdedcb7c9cd3430ead7ca56a83 294 Pfam PF00549 CoA-ligase 158 275 1.1E-12 T 09-03-2017 IPR005811 ATP-citrate lyase/succinyl-CoA ligase GO:0003824|GO:0008152 KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 TK78_RS12515 9b18cbbdedcb7c9cd3430ead7ca56a83 294 Gene3D G3DSA:3.40.50.720 3 125 2.3E-46 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS12515 9b18cbbdedcb7c9cd3430ead7ca56a83 294 SMART SM00881 4 104 1.9E-28 T 09-03-2017 IPR003781 CoA-binding GO:0048037 TK78_RS12515 9b18cbbdedcb7c9cd3430ead7ca56a83 294 ProSitePatterns PS00399 ATP-citrate lyase / succinyl-CoA ligases family active site. 240 253 - T 09-03-2017 IPR017440 ATP-citrate lyase/succinyl-CoA ligase, active site TK78_RS20900 5bc2ddcbd3406c78acabc7722a86ac3f 436 Pfam PF03454 MoeA C-terminal region (domain IV) 371 435 2.5E-17 T 09-03-2017 IPR005111 MoeA, C-terminal, domain IV GO:0032324 MetaCyc: PWY-6823|Reactome: R-HSA-947581 TK78_RS20900 5bc2ddcbd3406c78acabc7722a86ac3f 436 Pfam PF03453 MoeA N-terminal region (domain I and II) 7 192 1.6E-34 T 09-03-2017 IPR005110 MoeA, N-terminal and linker domain GO:0032324 MetaCyc: PWY-6823|Reactome: R-HSA-947581 TK78_RS20900 5bc2ddcbd3406c78acabc7722a86ac3f 436 Gene3D G3DSA:2.170.190.11 48 156 2.6E-32 T 09-03-2017 TK78_RS20900 5bc2ddcbd3406c78acabc7722a86ac3f 436 SUPERFAMILY SSF53218 201 355 1.96E-39 T 09-03-2017 IPR001453 MoaB/Mog domain TK78_RS20900 5bc2ddcbd3406c78acabc7722a86ac3f 436 Gene3D G3DSA:3.40.980.10 188 364 2.8E-60 T 09-03-2017 IPR001453 MoaB/Mog domain TK78_RS20900 5bc2ddcbd3406c78acabc7722a86ac3f 436 Gene3D G3DSA:3.90.105.10 157 187 1.9E-19 T 09-03-2017 TK78_RS20900 5bc2ddcbd3406c78acabc7722a86ac3f 436 SUPERFAMILY SSF63882 6 201 2.09E-46 T 09-03-2017 IPR005110 MoeA, N-terminal and linker domain GO:0032324 MetaCyc: PWY-6823|Reactome: R-HSA-947581 TK78_RS20900 5bc2ddcbd3406c78acabc7722a86ac3f 436 Gene3D G3DSA:2.40.340.10 365 436 1.3E-20 T 09-03-2017 IPR005111 MoeA, C-terminal, domain IV GO:0032324 MetaCyc: PWY-6823|Reactome: R-HSA-947581 TK78_RS20900 5bc2ddcbd3406c78acabc7722a86ac3f 436 SUPERFAMILY SSF63867 360 435 1.02E-15 T 09-03-2017 IPR005111 MoeA, C-terminal, domain IV GO:0032324 MetaCyc: PWY-6823|Reactome: R-HSA-947581 TK78_RS20900 5bc2ddcbd3406c78acabc7722a86ac3f 436 TIGRFAM TIGR00177 molyb_syn: molybdenum cofactor synthesis domain 202 347 5.1E-34 T 09-03-2017 IPR001453 MoaB/Mog domain TK78_RS20900 5bc2ddcbd3406c78acabc7722a86ac3f 436 SMART SM00852 205 351 4.4E-45 T 09-03-2017 IPR001453 MoaB/Mog domain TK78_RS20900 5bc2ddcbd3406c78acabc7722a86ac3f 436 Pfam PF00994 Probable molybdopterin binding domain 206 350 4.2E-30 T 09-03-2017 IPR001453 MoaB/Mog domain TK78_RS23710 68a73c2a73549c6e67a69ab011c90e42 302 Gene3D G3DSA:1.10.10.10 2 87 1.1E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS23710 68a73c2a73549c6e67a69ab011c90e42 302 Gene3D G3DSA:3.40.190.10 91 182 9.9E-15 T 09-03-2017 TK78_RS23710 68a73c2a73549c6e67a69ab011c90e42 302 SUPERFAMILY SSF46785 2 112 2.05E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS23710 68a73c2a73549c6e67a69ab011c90e42 302 SUPERFAMILY SSF53850 90 297 9.77E-38 T 09-03-2017 TK78_RS23710 68a73c2a73549c6e67a69ab011c90e42 302 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 5 62 4.1E-16 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS23710 68a73c2a73549c6e67a69ab011c90e42 302 Pfam PF03466 LysR substrate binding domain 88 295 4.7E-42 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS23710 68a73c2a73549c6e67a69ab011c90e42 302 Gene3D G3DSA:3.40.190.10 183 268 7.2E-24 T 09-03-2017 TK78_RS13110 4ed50416c13c4a5b09406e19ab0db5d8 107 SMART SM00739 2 29 2.9E-4 T 09-03-2017 IPR005824 KOW TK78_RS13110 4ed50416c13c4a5b09406e19ab0db5d8 107 SUPERFAMILY SSF50104 1 105 1.05E-29 T 09-03-2017 IPR008991 Translation protein SH3-like domain TK78_RS13110 4ed50416c13c4a5b09406e19ab0db5d8 107 Gene3D G3DSA:2.30.30.30 1 95 1.5E-25 T 09-03-2017 IPR014722 Ribosomal protein L2 domain 2 TK78_RS13110 4ed50416c13c4a5b09406e19ab0db5d8 107 TIGRFAM TIGR01079 rplX_bact: ribosomal protein uL24 1 107 1.8E-35 T 09-03-2017 IPR003256 Ribosomal protein L24 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13110 4ed50416c13c4a5b09406e19ab0db5d8 107 Pfam PF17136 Ribosomal proteins 50S L24/mitochondrial 39S L24 38 107 8.9E-24 T 09-03-2017 IPR003256 Ribosomal protein L24 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13110 4ed50416c13c4a5b09406e19ab0db5d8 107 ProSitePatterns PS01108 Ribosomal protein L24 signature. 6 23 - T 09-03-2017 IPR005825 Ribosomal protein L24/L26, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13110 4ed50416c13c4a5b09406e19ab0db5d8 107 Pfam PF00467 KOW motif 5 36 2.5E-6 T 09-03-2017 IPR005824 KOW TK78_RS13110 4ed50416c13c4a5b09406e19ab0db5d8 107 Hamap MF_01326_B 50S ribosomal protein L24 [rplX]. 1 101 21.063 T 09-03-2017 IPR003256 Ribosomal protein L24 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS05205 fd52b75cf7fc6d741f53431231f4cb60 421 Gene3D G3DSA:3.40.47.10 275 420 1.2E-54 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS05205 fd52b75cf7fc6d741f53431231f4cb60 421 SUPERFAMILY SSF53901 227 420 2.88E-65 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS05205 fd52b75cf7fc6d741f53431231f4cb60 421 SMART SM00825 Beta-ketoacyl synthase 19 421 9.7E-13 T 09-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TK78_RS05205 fd52b75cf7fc6d741f53431231f4cb60 421 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 20 258 2.7E-43 T 09-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal TK78_RS05205 fd52b75cf7fc6d741f53431231f4cb60 421 SUPERFAMILY SSF53901 19 264 4.45E-61 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS05205 fd52b75cf7fc6d741f53431231f4cb60 421 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 167 183 - T 09-03-2017 IPR018201 Beta-ketoacyl synthase, active site TK78_RS05205 fd52b75cf7fc6d741f53431231f4cb60 421 Gene3D G3DSA:3.40.47.10 21 272 8.5E-59 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS05205 fd52b75cf7fc6d741f53431231f4cb60 421 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 268 378 2.4E-32 T 09-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal TK78_RS32760 1b46920f4db3227ed13c3f7d444d3bf9 345 Gene3D G3DSA:3.40.50.300 2 182 1.3E-7 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS32760 1b46920f4db3227ed13c3f7d444d3bf9 345 SUPERFAMILY SSF55811 193 327 7.18E-24 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS32760 1b46920f4db3227ed13c3f7d444d3bf9 345 Pfam PF00293 NUDIX domain 200 325 1.4E-18 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS32760 1b46920f4db3227ed13c3f7d444d3bf9 345 PRINTS PR00502 NUDIX hydrolase family signature 225 239 1.9E-6 T 09-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 TK78_RS32760 1b46920f4db3227ed13c3f7d444d3bf9 345 PRINTS PR00502 NUDIX hydrolase family signature 239 254 1.9E-6 T 09-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 TK78_RS32760 1b46920f4db3227ed13c3f7d444d3bf9 345 Gene3D G3DSA:3.90.79.10 200 330 3.2E-24 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS32760 1b46920f4db3227ed13c3f7d444d3bf9 345 SUPERFAMILY SSF52540 2 180 1.81E-23 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17830 02ec4f80ac8c2f3e153bc492c5827a93 263 Pfam PF03734 L,D-transpeptidase catalytic domain 136 254 5.6E-7 T 09-03-2017 IPR005490 L,D-transpeptidase catalytic domain GO:0016740 TK78_RS14095 821f4a64d3aaf2b3c120b5148c587b3b 360 Gene3D G3DSA:1.10.101.10 121 178 3.7E-13 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS14095 821f4a64d3aaf2b3c120b5148c587b3b 360 SUPERFAMILY SSF47090 119 178 1.69E-13 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS14095 821f4a64d3aaf2b3c120b5148c587b3b 360 Pfam PF13437 HlyD family secretion protein 184 279 2.4E-6 T 09-03-2017 TK78_RS14095 821f4a64d3aaf2b3c120b5148c587b3b 360 Pfam PF01471 Putative peptidoglycan binding domain 129 178 1.6E-10 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS34205 7fb183017d7241b356fca6fe41a27748 165 Pfam PF12688 Tetratrico peptide repeat 45 161 4.2E-16 T 09-03-2017 TK78_RS34205 7fb183017d7241b356fca6fe41a27748 165 SUPERFAMILY SSF48452 8 159 4.05E-16 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS34205 7fb183017d7241b356fca6fe41a27748 165 Gene3D G3DSA:1.25.40.10 10 159 2.0E-19 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS29005 f86790c0d1572cc16b7bd26a6f0b2936 464 Gene3D G3DSA:3.40.605.10 5 256 4.8E-88 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS29005 f86790c0d1572cc16b7bd26a6f0b2936 464 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 244 251 - T 09-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 TK78_RS29005 f86790c0d1572cc16b7bd26a6f0b2936 464 Pfam PF00171 Aldehyde dehydrogenase family 13 461 1.1E-160 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS29005 f86790c0d1572cc16b7bd26a6f0b2936 464 Gene3D G3DSA:3.40.309.10 257 437 3.3E-58 T 09-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 TK78_RS29005 f86790c0d1572cc16b7bd26a6f0b2936 464 SUPERFAMILY SSF53720 4 462 6.02E-155 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS28030 d1786e1d3509a2d0da4fdb1549e94d9a 189 Gene3D G3DSA:1.10.357.10 8 186 2.6E-31 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS28030 d1786e1d3509a2d0da4fdb1549e94d9a 189 SUPERFAMILY SSF46689 5 72 2.36E-15 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS28030 d1786e1d3509a2d0da4fdb1549e94d9a 189 SUPERFAMILY SSF48498 105 185 4.45E-7 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS28030 d1786e1d3509a2d0da4fdb1549e94d9a 189 Pfam PF00440 Bacterial regulatory proteins, tetR family 13 59 3.1E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS11975 092bb7e7698b8f048b945c76e9bac490 289 Gene3D G3DSA:3.30.930.10 29 218 4.7E-51 T 09-03-2017 TK78_RS11975 092bb7e7698b8f048b945c76e9bac490 289 SUPERFAMILY SSF55681 29 217 9.28E-42 T 09-03-2017 TK78_RS11975 092bb7e7698b8f048b945c76e9bac490 289 Gene3D G3DSA:2.30.30.100 235 278 1.3E-5 T 09-03-2017 TK78_RS11975 092bb7e7698b8f048b945c76e9bac490 289 TIGRFAM TIGR00121 birA_ligase: biotin--[acetyl-CoA-carboxylase] ligase 39 280 5.9E-40 T 09-03-2017 IPR004408 Biotin--acetyl-CoA-carboxylase ligase GO:0004077|GO:0006464 Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TK78_RS11975 092bb7e7698b8f048b945c76e9bac490 289 Pfam PF02237 Biotin protein ligase C terminal domain 233 280 5.2E-11 T 09-03-2017 IPR003142 Biotin protein ligase, C-terminal GO:0006464 KEGG: 00780+6.3.4.15|Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TK78_RS11975 092bb7e7698b8f048b945c76e9bac490 289 Pfam PF03099 Biotin/lipoate A/B protein ligase family 42 167 1.9E-9 T 09-03-2017 IPR004143 Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain GO:0006464 TK78_RS07500 2f116f74a3ea3fd98464c1f39b541038 206 SUPERFAMILY SSF53597 8 195 1.18E-27 T 09-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 TK78_RS07500 2f116f74a3ea3fd98464c1f39b541038 206 Pfam PF01872 RibD C-terminal domain 8 199 1.3E-32 T 09-03-2017 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 TK78_RS07500 2f116f74a3ea3fd98464c1f39b541038 206 Gene3D G3DSA:3.40.430.10 6 204 1.4E-41 T 09-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 TK78_RS10040 1da6cdb09be545b8b64a5a9b6f262240 179 Pfam PF13302 Acetyltransferase (GNAT) domain 11 146 4.3E-21 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS10040 1da6cdb09be545b8b64a5a9b6f262240 179 SUPERFAMILY SSF55729 6 170 7.02E-33 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS10040 1da6cdb09be545b8b64a5a9b6f262240 179 Gene3D G3DSA:3.40.630.30 8 172 8.6E-39 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS08450 cd8002d0405a225fba5768af44235b86 1083 Gene3D G3DSA:3.30.565.10 573 696 7.6E-12 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS08450 cd8002d0405a225fba5768af44235b86 1083 SMART SM00387 587 699 3.7E-8 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS08450 cd8002d0405a225fba5768af44235b86 1083 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 590 697 5.8E-9 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS08450 cd8002d0405a225fba5768af44235b86 1083 Pfam PF08376 Nitrate and nitrite sensing 102 365 4.7E-46 T 09-03-2017 IPR013587 Nitrate/nitrite sensing protein TK78_RS08450 cd8002d0405a225fba5768af44235b86 1083 Pfam PF00672 HAMP domain 387 471 1.2E-12 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS08450 cd8002d0405a225fba5768af44235b86 1083 SUPERFAMILY SSF55874 579 696 1.57E-14 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS08450 cd8002d0405a225fba5768af44235b86 1083 SMART SM00304 405 475 2.8E-4 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS06100 db807457f9e2ef8b9dd5ee6d96fbd860 228 SUPERFAMILY SSF56784 11 203 1.25E-37 T 09-03-2017 IPR023214 HAD-like domain TK78_RS06100 db807457f9e2ef8b9dd5ee6d96fbd860 228 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 14 186 2.5E-14 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS06100 db807457f9e2ef8b9dd5ee6d96fbd860 228 Gene3D G3DSA:3.40.50.1000 10 25 6.8E-34 T 09-03-2017 IPR023214 HAD-like domain TK78_RS06100 db807457f9e2ef8b9dd5ee6d96fbd860 228 Gene3D G3DSA:3.40.50.1000 93 191 6.8E-34 T 09-03-2017 IPR023214 HAD-like domain TK78_RS06100 db807457f9e2ef8b9dd5ee6d96fbd860 228 Pfam PF13419 Haloacid dehalogenase-like hydrolase 14 186 4.4E-18 T 09-03-2017 IPR023214 HAD-like domain TK78_RS20505 4a992074caa0dec3a7d4fbef09f9edfe 281 Gene3D G3DSA:3.20.20.30 17 239 8.5E-60 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS20505 4a992074caa0dec3a7d4fbef09f9edfe 281 TIGRFAM TIGR03619 F420_Rv2161c: probable F420-dependent oxidoreductase, Rv2161c family 18 261 6.7E-68 T 09-03-2017 IPR019921 Luciferase-like, F420-dependent oxidoreductase, Rv2161c, predicted TK78_RS20505 4a992074caa0dec3a7d4fbef09f9edfe 281 Pfam PF00296 Luciferase-like monooxygenase 17 238 7.2E-47 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS20505 4a992074caa0dec3a7d4fbef09f9edfe 281 SUPERFAMILY SSF51679 17 279 5.89E-54 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS31955 7f8e2c68a644d445c475460d59c13bc1 136 SUPERFAMILY SSF54534 10 126 2.95E-35 T 09-03-2017 TK78_RS31955 7f8e2c68a644d445c475460d59c13bc1 136 Pfam PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 31 122 1.9E-27 T 09-03-2017 IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain GO:0006457 TK78_RS31955 7f8e2c68a644d445c475460d59c13bc1 136 Gene3D G3DSA:3.10.50.40 11 126 1.3E-37 T 09-03-2017 TK78_RS19840 358ef91c1d0617d7faed6a4544f563f5 223 ProSitePatterns PS01063 Sigma-70 factors ECF subfamily signature. 34 65 - T 09-03-2017 IPR000838 RNA polymerase sigma factor 70, ECF, conserved site GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS19840 358ef91c1d0617d7faed6a4544f563f5 223 Pfam PF08281 Sigma-70, region 4 104 155 3.3E-16 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS19840 358ef91c1d0617d7faed6a4544f563f5 223 TIGRFAM TIGR02983 SigE-fam_strep: RNA polymerase sigma-70 factor, sigma-E family 4 162 2.1E-59 T 09-03-2017 IPR014325 RNA polymerase sigma-E factor, actinobacteria GO:0016987 TK78_RS19840 358ef91c1d0617d7faed6a4544f563f5 223 Gene3D G3DSA:1.10.1740.10 2 79 5.9E-14 T 09-03-2017 TK78_RS19840 358ef91c1d0617d7faed6a4544f563f5 223 SUPERFAMILY SSF88659 97 160 5.61E-16 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS19840 358ef91c1d0617d7faed6a4544f563f5 223 Gene3D G3DSA:1.10.10.10 97 160 1.5E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS19840 358ef91c1d0617d7faed6a4544f563f5 223 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 8 159 4.3E-25 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS19840 358ef91c1d0617d7faed6a4544f563f5 223 Pfam PF04542 Sigma-70 region 2 16 78 1.1E-7 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS19840 358ef91c1d0617d7faed6a4544f563f5 223 SUPERFAMILY SSF88946 2 87 7.46E-13 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS06380 f6aa63b058b140fbf054be18e5d840d1 572 ProSitePatterns PS00455 Putative AMP-binding domain signature. 228 239 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS06380 f6aa63b058b140fbf054be18e5d840d1 572 SUPERFAMILY SSF56801 57 565 1.31E-134 T 09-03-2017 TK78_RS06380 f6aa63b058b140fbf054be18e5d840d1 572 Pfam PF00501 AMP-binding enzyme 74 469 7.5E-79 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS06380 f6aa63b058b140fbf054be18e5d840d1 572 Gene3D G3DSA:3.30.300.30 464 561 3.0E-32 T 09-03-2017 TK78_RS06380 f6aa63b058b140fbf054be18e5d840d1 572 Pfam PF13193 AMP-binding enzyme C-terminal domain 478 553 2.8E-23 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS06380 f6aa63b058b140fbf054be18e5d840d1 572 Gene3D G3DSA:3.40.50.980 70 233 3.8E-30 T 09-03-2017 TK78_RS06380 f6aa63b058b140fbf054be18e5d840d1 572 Gene3D G3DSA:3.40.50.980 234 383 1.1E-32 T 09-03-2017 TK78_RS06380 f6aa63b058b140fbf054be18e5d840d1 572 Gene3D G3DSA:2.30.38.10 388 460 8.3E-16 T 09-03-2017 TK78_RS26915 559f9998b9f2e948ddce4161ed48061c 332 SUPERFAMILY SSF51735 101 297 1.97E-51 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS26915 559f9998b9f2e948ddce4161ed48061c 332 Gene3D G3DSA:3.40.50.720 118 299 1.4E-53 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS26915 559f9998b9f2e948ddce4161ed48061c 332 Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 6 327 3.8E-23 T 09-03-2017 IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0008152|GO:0016616|GO:0051287|GO:0055114 TK78_RS26915 559f9998b9f2e948ddce4161ed48061c 332 SUPERFAMILY SSF52283 2 134 7.02E-29 T 09-03-2017 TK78_RS26915 559f9998b9f2e948ddce4161ed48061c 332 ProSitePatterns PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 222 238 - T 09-03-2017 IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site TK78_RS26915 559f9998b9f2e948ddce4161ed48061c 332 ProSitePatterns PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 146 173 - T 09-03-2017 IPR029752 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 TK78_RS26915 559f9998b9f2e948ddce4161ed48061c 332 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 110 296 1.2E-49 T 09-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 TK78_RS26915 559f9998b9f2e948ddce4161ed48061c 332 Gene3D G3DSA:3.40.50.720 16 117 5.4E-19 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31620 6b8ad8b599991a07cdceac5a54f93e4d 573 TIGRFAM TIGR01792 urease_alph: urease, alpha subunit 4 573 2.5E-269 T 09-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 TK78_RS31620 6b8ad8b599991a07cdceac5a54f93e4d 573 PRINTS PR01752 Urea amidohydrolase (urease) protein signature 407 422 1.1E-32 T 09-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 TK78_RS31620 6b8ad8b599991a07cdceac5a54f93e4d 573 PRINTS PR01752 Urea amidohydrolase (urease) protein signature 341 357 1.1E-32 T 09-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 TK78_RS31620 6b8ad8b599991a07cdceac5a54f93e4d 573 PRINTS PR01752 Urea amidohydrolase (urease) protein signature 433 446 1.1E-32 T 09-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 TK78_RS31620 6b8ad8b599991a07cdceac5a54f93e4d 573 PRINTS PR01752 Urea amidohydrolase (urease) protein signature 302 319 1.1E-32 T 09-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 TK78_RS31620 6b8ad8b599991a07cdceac5a54f93e4d 573 SUPERFAMILY SSF51338 415 485 4.68E-12 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS31620 6b8ad8b599991a07cdceac5a54f93e4d 573 Hamap MF_01953 Urease subunit alpha [ureC]. 2 573 55.296 T 09-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 TK78_RS31620 6b8ad8b599991a07cdceac5a54f93e4d 573 ProSitePatterns PS01120 Urease nickel ligands signature. 134 147 - T 09-03-2017 IPR029754 Urease nickel binding site GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 TK78_RS31620 6b8ad8b599991a07cdceac5a54f93e4d 573 SUPERFAMILY SSF51338 2 184 9.4E-57 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS31620 6b8ad8b599991a07cdceac5a54f93e4d 573 Pfam PF01979 Amidohydrolase family 133 458 1.4E-65 T 09-03-2017 IPR006680 Amidohydrolase-related GO:0016787 TK78_RS31620 6b8ad8b599991a07cdceac5a54f93e4d 573 SUPERFAMILY SSF51556 136 438 4.86E-185 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS31620 6b8ad8b599991a07cdceac5a54f93e4d 573 SUPERFAMILY SSF51556 487 573 4.86E-185 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS31620 6b8ad8b599991a07cdceac5a54f93e4d 573 ProSitePatterns PS00145 Urease active site. 324 340 - T 09-03-2017 IPR017950 Urease active site GO:0009039 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 TK78_RS31620 6b8ad8b599991a07cdceac5a54f93e4d 573 Gene3D G3DSA:3.20.20.140 494 571 1.5E-194 T 09-03-2017 TK78_RS31620 6b8ad8b599991a07cdceac5a54f93e4d 573 Gene3D G3DSA:3.20.20.140 151 435 1.5E-194 T 09-03-2017 TK78_RS31620 6b8ad8b599991a07cdceac5a54f93e4d 573 Gene3D G3DSA:2.30.40.10 72 150 2.7E-13 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS31620 6b8ad8b599991a07cdceac5a54f93e4d 573 Pfam PF00449 Urease alpha-subunit, N-terminal domain 4 126 1.2E-53 T 09-03-2017 IPR011612 Urease alpha-subunit, N-terminal domain KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 TK78_RS22185 01706ff4cb70428df9b6b295dcfd42bb 274 Gene3D G3DSA:3.40.50.150 49 171 5.3E-15 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS22185 01706ff4cb70428df9b6b295dcfd42bb 274 SUPERFAMILY SSF53335 49 171 3.58E-17 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS22185 01706ff4cb70428df9b6b295dcfd42bb 274 Pfam PF08241 Methyltransferase domain 68 119 1.0E-7 T 09-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 TK78_RS12825 9b5bdd2a6d8130231ad054efdd65d57d 372 ProSitePatterns PS01016 Glycoprotease family signature. 100 120 - T 09-03-2017 IPR017860 Peptidase M22, conserved site KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618|Reactome: R-HSA-6782315 TK78_RS12825 9b5bdd2a6d8130231ad054efdd65d57d 372 SUPERFAMILY SSF53067 7 317 3.24E-38 T 09-03-2017 TK78_RS12825 9b5bdd2a6d8130231ad054efdd65d57d 372 Gene3D G3DSA:3.30.420.40 7 164 2.1E-46 T 09-03-2017 TK78_RS12825 9b5bdd2a6d8130231ad054efdd65d57d 372 Pfam PF00814 Glycoprotease family 28 315 3.9E-99 T 09-03-2017 IPR000905 Gcp-like domain KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 TK78_RS12825 9b5bdd2a6d8130231ad054efdd65d57d 372 TIGRFAM TIGR00329 gcp_kae1: metallohydrolase, glycoprotease/Kae1 family 9 315 1.2E-99 T 09-03-2017 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 TK78_RS12825 9b5bdd2a6d8130231ad054efdd65d57d 372 TIGRFAM TIGR03723 T6A_TsaD_YgjD: tRNA threonylcarbamoyl adenosine modification protein TsaD 8 322 2.3E-127 T 09-03-2017 IPR022450 tRNA N6-adenosine threonylcarbamoyltransferase, TsaD GO:0002949|GO:0004222 KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 TK78_RS12825 9b5bdd2a6d8130231ad054efdd65d57d 372 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 272 281 7.3E-51 T 09-03-2017 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 TK78_RS12825 9b5bdd2a6d8130231ad054efdd65d57d 372 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 101 120 7.3E-51 T 09-03-2017 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 TK78_RS12825 9b5bdd2a6d8130231ad054efdd65d57d 372 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 9 22 7.3E-51 T 09-03-2017 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 TK78_RS12825 9b5bdd2a6d8130231ad054efdd65d57d 372 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 135 147 7.3E-51 T 09-03-2017 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 TK78_RS12825 9b5bdd2a6d8130231ad054efdd65d57d 372 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 80 100 7.3E-51 T 09-03-2017 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 TK78_RS12825 9b5bdd2a6d8130231ad054efdd65d57d 372 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 159 180 7.3E-51 T 09-03-2017 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 TK78_RS12825 9b5bdd2a6d8130231ad054efdd65d57d 372 Hamap MF_01445 tRNA N6-adenosine threonylcarbamoyltransferase [tsaD]. 6 341 63.047 T 09-03-2017 IPR022450 tRNA N6-adenosine threonylcarbamoyltransferase, TsaD GO:0002949|GO:0004222 KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 TK78_RS20705 4386150e48414a6f984312ecc50cca33 314 SUPERFAMILY SSF56349 14 289 5.59E-13 T 09-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 TK78_RS08770 0e802b548a4b30285e7b17ae6c23d60f 333 Hamap MF_00435 Ketol-acid reductoisomerase [ilvC]. 2 329 44.754 T 09-03-2017 IPR013023 Ketol-acid reductoisomerase GO:0009082|GO:0016491|GO:0055114 KEGG: 00290+1.1.1.86|KEGG: 00770+1.1.1.86|MetaCyc: PWY-5103|MetaCyc: PWY-7111 TK78_RS08770 0e802b548a4b30285e7b17ae6c23d60f 333 SUPERFAMILY SSF48179 184 331 4.08E-69 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS08770 0e802b548a4b30285e7b17ae6c23d60f 333 Pfam PF07991 Acetohydroxy acid isomeroreductase, NADPH-binding domain 15 178 2.1E-76 T 09-03-2017 IPR013116 Acetohydroxy acid isomeroreductase, NADPH-binding domain KEGG: 00290+1.1.1.86|KEGG: 00770+1.1.1.86|MetaCyc: PWY-5103|MetaCyc: PWY-7111 TK78_RS08770 0e802b548a4b30285e7b17ae6c23d60f 333 SUPERFAMILY SSF51735 3 183 1.69E-72 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS08770 0e802b548a4b30285e7b17ae6c23d60f 333 TIGRFAM TIGR00465 ilvC: ketol-acid reductoisomerase 15 327 3.5E-133 T 09-03-2017 IPR013023 Ketol-acid reductoisomerase GO:0009082|GO:0016491|GO:0055114 KEGG: 00290+1.1.1.86|KEGG: 00770+1.1.1.86|MetaCyc: PWY-5103|MetaCyc: PWY-7111 TK78_RS08770 0e802b548a4b30285e7b17ae6c23d60f 333 Gene3D G3DSA:1.10.1040.10 30 326 2.0E-111 T 09-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 TK78_RS08770 0e802b548a4b30285e7b17ae6c23d60f 333 Pfam PF01450 Acetohydroxy acid isomeroreductase, catalytic domain 184 327 2.2E-64 T 09-03-2017 IPR000506 Acetohydroxy acid isomeroreductase C-terminal GO:0004455|GO:0009082|GO:0055114 KEGG: 00290+1.1.1.86|KEGG: 00770+1.1.1.86|MetaCyc: PWY-5103|MetaCyc: PWY-7111 TK78_RS34385 c6858c527294be135c388dbd8d1eb9ff 310 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 143 164 - T 09-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 TK78_RS34385 c6858c527294be135c388dbd8d1eb9ff 310 Pfam PF13602 Zinc-binding dehydrogenase 185 307 3.2E-29 T 09-03-2017 TK78_RS34385 c6858c527294be135c388dbd8d1eb9ff 310 Gene3D G3DSA:3.90.180.10 1 148 6.4E-43 T 09-03-2017 IPR011032 GroES-like TK78_RS34385 c6858c527294be135c388dbd8d1eb9ff 310 SMART SM00829 10 307 9.1E-42 T 09-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 TK78_RS34385 c6858c527294be135c388dbd8d1eb9ff 310 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 28 86 1.2E-7 T 09-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 TK78_RS34385 c6858c527294be135c388dbd8d1eb9ff 310 SUPERFAMILY SSF51735 115 239 5.22E-38 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS34385 c6858c527294be135c388dbd8d1eb9ff 310 SUPERFAMILY SSF50129 1 148 1.38E-35 T 09-03-2017 IPR011032 GroES-like TK78_RS34385 c6858c527294be135c388dbd8d1eb9ff 310 Gene3D G3DSA:3.40.50.720 149 250 1.1E-22 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS27795 a465a5902d632d60a384b61a3690f4b2 713 Gene3D G3DSA:3.40.50.300 15 98 9.4E-49 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27795 a465a5902d632d60a384b61a3690f4b2 713 Gene3D G3DSA:3.40.50.300 286 346 9.4E-49 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27795 a465a5902d632d60a384b61a3690f4b2 713 Gene3D G3DSA:3.40.50.300 396 416 9.4E-49 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27795 a465a5902d632d60a384b61a3690f4b2 713 Gene3D G3DSA:3.40.50.300 426 589 4.5E-38 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27795 a465a5902d632d60a384b61a3690f4b2 713 Pfam PF12344 Ultra-violet resistance protein B 559 600 3.3E-20 T 09-03-2017 IPR024759 UvrB, YAD/RRR-motif-containing domain TK78_RS27795 a465a5902d632d60a384b61a3690f4b2 713 SUPERFAMILY SSF52540 13 422 8.8E-134 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27795 a465a5902d632d60a384b61a3690f4b2 713 SUPERFAMILY SSF52540 42 91 1.33E-34 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27795 a465a5902d632d60a384b61a3690f4b2 713 SUPERFAMILY SSF52540 466 586 1.33E-34 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27795 a465a5902d632d60a384b61a3690f4b2 713 TIGRFAM TIGR00631 uvrb: excinuclease ABC subunit B 14 701 0.0 T 09-03-2017 IPR004807 UvrABC system, subunit B GO:0003677|GO:0005524|GO:0006281|GO:0006289|GO:0009381|GO:0009432 TK78_RS27795 a465a5902d632d60a384b61a3690f4b2 713 SMART SM00487 18 433 3.2E-26 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS27795 a465a5902d632d60a384b61a3690f4b2 713 Pfam PF02151 UvrB/uvrC motif 671 703 7.5E-7 T 09-03-2017 IPR001943 UVR domain GO:0005515 TK78_RS27795 a465a5902d632d60a384b61a3690f4b2 713 Gene3D G3DSA:3.30.2060.10 168 237 8.5E-12 T 09-03-2017 TK78_RS27795 a465a5902d632d60a384b61a3690f4b2 713 SMART SM00490 467 553 2.3E-18 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS27795 a465a5902d632d60a384b61a3690f4b2 713 Gene3D G3DSA:4.10.860.10 663 707 2.0E-12 T 09-03-2017 IPR001943 UVR domain GO:0005515 TK78_RS27795 a465a5902d632d60a384b61a3690f4b2 713 SUPERFAMILY SSF46600 664 706 3.14E-9 T 09-03-2017 IPR001943 UVR domain GO:0005515 TK78_RS27795 a465a5902d632d60a384b61a3690f4b2 713 Pfam PF00271 Helicase conserved C-terminal domain 439 552 1.9E-19 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS27795 a465a5902d632d60a384b61a3690f4b2 713 Pfam PF04851 Type III restriction enzyme, res subunit 25 134 5.4E-9 T 09-03-2017 IPR006935 Helicase/UvrB, N-terminal GO:0003677|GO:0005524|GO:0016787 TK78_RS27795 a465a5902d632d60a384b61a3690f4b2 713 Hamap MF_00204 UvrABC system protein B [uvrB]. 12 703 42.345 T 09-03-2017 IPR004807 UvrABC system, subunit B GO:0003677|GO:0005524|GO:0006281|GO:0006289|GO:0009381|GO:0009432 TK78_RS22515 998d9e0796cfd3afba5867261efa60be 422 Pfam PF00571 CBS domain 341 383 0.0036 T 09-03-2017 IPR000644 CBS domain TK78_RS22515 998d9e0796cfd3afba5867261efa60be 422 ProSitePatterns PS00211 ABC transporters family signature. 159 173 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS22515 998d9e0796cfd3afba5867261efa60be 422 TIGRFAM TIGR01186 proV: glycine betaine/L-proline transport ATP binding subunit 39 387 8.3E-103 T 09-03-2017 IPR005892 Glycine betaine transport ATP-binding subunit GO:0005524|GO:0016020|GO:0031460 TK78_RS22515 998d9e0796cfd3afba5867261efa60be 422 Gene3D G3DSA:3.40.50.300 14 259 1.6E-79 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22515 998d9e0796cfd3afba5867261efa60be 422 Gene3D G3DSA:3.20.20.70 270 388 1.5E-6 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS22515 998d9e0796cfd3afba5867261efa60be 422 Pfam PF00005 ABC transporter 41 186 1.1E-36 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS22515 998d9e0796cfd3afba5867261efa60be 422 SMART SM00382 49 245 5.3E-20 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS22515 998d9e0796cfd3afba5867261efa60be 422 SUPERFAMILY SSF52540 23 262 8.68E-77 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22515 998d9e0796cfd3afba5867261efa60be 422 SUPERFAMILY SSF54631 273 393 4.8E-10 T 09-03-2017 TK78_RS33795 f4f8f73e53ea0900de999c125c926b57 530 ProSitePatterns PS00510 Malate synthase signature. 266 281 - T 09-03-2017 IPR019830 Malate synthase, conserved site GO:0004474|GO:0006097 KEGG: 00620+2.3.3.9|KEGG: 00630+2.3.3.9|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7118|MetaCyc: PWY-7294|MetaCyc: PWY-7295 TK78_RS33795 f4f8f73e53ea0900de999c125c926b57 530 TIGRFAM TIGR01344 malate_syn_A: malate synthase A 23 519 1.1E-216 T 09-03-2017 IPR006252 Malate synthase A GO:0004474|GO:0006097 KEGG: 00620+2.3.3.9|KEGG: 00630+2.3.3.9|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7118|MetaCyc: PWY-7294|MetaCyc: PWY-7295 TK78_RS33795 f4f8f73e53ea0900de999c125c926b57 530 SUPERFAMILY SSF51645 8 521 5.36E-171 T 09-03-2017 IPR011076 Malate synthase-like GO:0003824 KEGG: 00620+2.3.3.9|KEGG: 00630+2.3.3.9|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7118|MetaCyc: PWY-7294|MetaCyc: PWY-7295 TK78_RS33795 f4f8f73e53ea0900de999c125c926b57 530 Pfam PF01274 Malate synthase 17 519 4.1E-177 T 09-03-2017 IPR001465 Malate synthase GO:0004474|GO:0006097 KEGG: 00620+2.3.3.9|KEGG: 00630+2.3.3.9|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7118|MetaCyc: PWY-7294|MetaCyc: PWY-7295 TK78_RS33795 f4f8f73e53ea0900de999c125c926b57 530 Gene3D G3DSA:1.20.1220.12 414 515 2.6E-26 T 09-03-2017 TK78_RS33795 f4f8f73e53ea0900de999c125c926b57 530 PIRSF PIRSF001363 1 523 4.2E-227 T 09-03-2017 IPR006252 Malate synthase A GO:0004474|GO:0006097 KEGG: 00620+2.3.3.9|KEGG: 00630+2.3.3.9|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7118|MetaCyc: PWY-7294|MetaCyc: PWY-7295 TK78_RS33795 f4f8f73e53ea0900de999c125c926b57 530 Gene3D G3DSA:3.20.20.360 73 408 2.3E-115 T 09-03-2017 TK78_RS09085 5cd9fe36c212c9bdbdf7463dc785cac6 358 SUPERFAMILY SSF53901 26 343 1.7E-56 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS09085 5cd9fe36c212c9bdbdf7463dc785cac6 358 Gene3D G3DSA:3.40.47.10 18 171 1.1E-46 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS09085 5cd9fe36c212c9bdbdf7463dc785cac6 358 TIGRFAM TIGR00747 fabH: 3-oxoacyl-[acyl-carrier-protein] synthase III 22 342 1.2E-89 T 09-03-2017 IPR004655 3-oxoacyl-[acyl-carrier-protein] synthase 3 GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 TK78_RS09085 5cd9fe36c212c9bdbdf7463dc785cac6 358 Gene3D G3DSA:3.40.47.10 172 344 2.9E-48 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS09085 5cd9fe36c212c9bdbdf7463dc785cac6 358 Pfam PF08541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal 253 342 2.3E-34 T 09-03-2017 IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, C-terminal KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 TK78_RS09085 5cd9fe36c212c9bdbdf7463dc785cac6 358 Pfam PF08545 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III 119 199 3.2E-25 T 09-03-2017 IPR013751 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 TK78_RS09085 5cd9fe36c212c9bdbdf7463dc785cac6 358 Hamap MF_01815 3-oxoacyl-[acyl-carrier-protein] synthase 3 [fabH]. 18 342 56.153 T 09-03-2017 IPR004655 3-oxoacyl-[acyl-carrier-protein] synthase 3 GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 TK78_RS03990 90f2b4b3bb5f92ed07c606412ae7ff01 599 SUPERFAMILY SSF56801 340 597 8.63E-112 T 09-03-2017 TK78_RS03990 90f2b4b3bb5f92ed07c606412ae7ff01 599 SUPERFAMILY SSF56801 10 286 8.63E-112 T 09-03-2017 TK78_RS03990 90f2b4b3bb5f92ed07c606412ae7ff01 599 Gene3D G3DSA:3.40.50.980 183 281 4.1E-26 T 09-03-2017 TK78_RS03990 90f2b4b3bb5f92ed07c606412ae7ff01 599 Gene3D G3DSA:3.40.50.980 337 399 4.1E-26 T 09-03-2017 TK78_RS03990 90f2b4b3bb5f92ed07c606412ae7ff01 599 Gene3D G3DSA:3.30.300.30 467 589 8.2E-6 T 09-03-2017 TK78_RS03990 90f2b4b3bb5f92ed07c606412ae7ff01 599 Gene3D G3DSA:2.30.38.10 400 460 3.3E-21 T 09-03-2017 TK78_RS03990 90f2b4b3bb5f92ed07c606412ae7ff01 599 ProSitePatterns PS00455 Putative AMP-binding domain signature. 176 187 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS03990 90f2b4b3bb5f92ed07c606412ae7ff01 599 Pfam PF00501 AMP-binding enzyme 17 469 4.7E-92 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS03990 90f2b4b3bb5f92ed07c606412ae7ff01 599 Gene3D G3DSA:3.40.50.980 12 182 2.3E-32 T 09-03-2017 TK78_RS14260 bb1fae8fe4c33a5520b8c36c7d524aad 532 SUPERFAMILY SSF55874 245 369 1.31E-19 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS14260 bb1fae8fe4c33a5520b8c36c7d524aad 532 Gene3D G3DSA:3.30.565.10 262 369 1.6E-18 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS14260 bb1fae8fe4c33a5520b8c36c7d524aad 532 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 262 368 5.1E-10 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS14260 bb1fae8fe4c33a5520b8c36c7d524aad 532 SMART SM00387 259 370 4.1E-13 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS08270 5283e30c3eac04303edba395d6a25719 57 SUPERFAMILY SSF57829 2 56 3.72E-21 T 09-03-2017 IPR011332 Zinc-binding ribosomal protein GO:0006412 TK78_RS08270 5283e30c3eac04303edba395d6a25719 57 Pfam PF01783 Ribosomal L32p protein family 2 56 3.4E-26 T 09-03-2017 IPR002677 Ribosomal protein L32p GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS08270 5283e30c3eac04303edba395d6a25719 57 Hamap MF_00340 50S ribosomal protein L32 [rpmF]. 2 55 19.016 T 09-03-2017 IPR002677 Ribosomal protein L32p GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS08270 5283e30c3eac04303edba395d6a25719 57 TIGRFAM TIGR01031 rpmF_bact: ribosomal protein bL32 2 56 2.5E-26 T 09-03-2017 IPR002677 Ribosomal protein L32p GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS16135 d22424ab687a94edc53c838d54c396c3 326 Gene3D G3DSA:1.10.1740.10 8 95 3.8E-25 T 09-03-2017 TK78_RS16135 d22424ab687a94edc53c838d54c396c3 326 Pfam PF04542 Sigma-70 region 2 14 78 9.1E-18 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16135 d22424ab687a94edc53c838d54c396c3 326 SUPERFAMILY SSF88659 122 179 8.22E-12 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16135 d22424ab687a94edc53c838d54c396c3 326 Gene3D G3DSA:1.10.10.10 121 180 3.1E-14 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS16135 d22424ab687a94edc53c838d54c396c3 326 SUPERFAMILY SSF88946 7 85 5.49E-21 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16135 d22424ab687a94edc53c838d54c396c3 326 TIGRFAM TIGR02960 SigX5: RNA polymerase sigma-70 factor, TIGR02960 family 11 312 5.7E-107 T 09-03-2017 IPR014305 RNA polymerase sigma-G type, actinobacteria TK78_RS16135 d22424ab687a94edc53c838d54c396c3 326 Pfam PF08281 Sigma-70, region 4 125 177 2.3E-13 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16135 d22424ab687a94edc53c838d54c396c3 326 SUPERFAMILY SSF54427 198 307 8.25E-13 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS16135 d22424ab687a94edc53c838d54c396c3 326 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 15 178 9.6E-20 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16135 d22424ab687a94edc53c838d54c396c3 326 Gene3D G3DSA:3.10.450.50 199 310 1.4E-15 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS04225 c9f86707a5b9d79d18852c8b4d3211fb 670 Gene3D G3DSA:3.40.50.280 511 659 3.4E-48 T 09-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 TK78_RS04225 c9f86707a5b9d79d18852c8b4d3211fb 670 Pfam PF01642 Methylmalonyl-CoA mutase 3 490 1.7E-134 T 09-03-2017 IPR006099 Methylmalonyl-CoA mutase, alpha/beta chain, catalytic GO:0008152|GO:0016866|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 TK78_RS04225 c9f86707a5b9d79d18852c8b4d3211fb 670 SUPERFAMILY SSF52242 512 653 4.45E-43 T 09-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 TK78_RS04225 c9f86707a5b9d79d18852c8b4d3211fb 670 Pfam PF02310 B12 binding domain 534 639 1.2E-16 T 09-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 TK78_RS04225 c9f86707a5b9d79d18852c8b4d3211fb 670 TIGRFAM TIGR00641 acid_CoA_mut_N: methylmalonyl-CoA mutase N-terminal domain 7 496 7.8E-142 T 09-03-2017 IPR006098 Methylmalonyl-CoA mutase, alpha chain, catalytic GO:0004494|GO:0008152|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 TK78_RS04225 c9f86707a5b9d79d18852c8b4d3211fb 670 SUPERFAMILY SSF51703 4 492 2.88E-162 T 09-03-2017 IPR016176 Cobalamin (vitamin B12)-dependent enzyme, catalytic GO:0003824|GO:0008152|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 TK78_RS04225 c9f86707a5b9d79d18852c8b4d3211fb 670 TIGRFAM TIGR00640 acid_CoA_mut_C: methylmalonyl-CoA mutase C-terminal domain 531 661 8.0E-40 T 09-03-2017 IPR006159 Methylmalonyl-CoA mutase, C-terminal GO:0016853 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 TK78_RS04225 c9f86707a5b9d79d18852c8b4d3211fb 670 Gene3D G3DSA:3.20.20.240 3 491 5.1E-189 T 09-03-2017 IPR014348 Cobalamin (vitamin B12)-dependent enzyme, catalytic subdomain GO:0008152|GO:0016866|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 TK78_RS22535 692e6684807c37eb0748fef02306b5b3 554 SUPERFAMILY SSF48452 261 362 6.32E-16 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS22535 692e6684807c37eb0748fef02306b5b3 554 SUPERFAMILY SSF48452 401 468 6.32E-16 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS22535 692e6684807c37eb0748fef02306b5b3 554 SUPERFAMILY SSF48452 107 244 7.82E-7 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS22535 692e6684807c37eb0748fef02306b5b3 554 SMART SM00028 262 295 0.14 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS22535 692e6684807c37eb0748fef02306b5b3 554 SMART SM00028 296 329 0.3 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS22535 692e6684807c37eb0748fef02306b5b3 554 SMART SM00028 435 468 15.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS22535 692e6684807c37eb0748fef02306b5b3 554 Pfam PF14559 Tetratricopeptide repeat 273 333 1.1E-5 T 09-03-2017 TK78_RS22535 692e6684807c37eb0748fef02306b5b3 554 Gene3D G3DSA:1.25.40.10 100 241 2.5E-8 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS22535 692e6684807c37eb0748fef02306b5b3 554 Gene3D G3DSA:1.25.40.10 242 475 1.7E-24 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS09350 9e650af89998fa8a853695e9446bc092 473 Pfam PF01636 Phosphotransferase enzyme family 209 421 9.1E-9 T 09-03-2017 IPR002575 Aminoglycoside phosphotransferase TK78_RS09350 9e650af89998fa8a853695e9446bc092 473 Gene3D G3DSA:3.90.1200.10 264 425 3.0E-7 T 09-03-2017 TK78_RS09350 9e650af89998fa8a853695e9446bc092 473 SUPERFAMILY SSF56112 164 468 2.38E-20 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 SUPERFAMILY SSF50447 277 417 1.46E-36 T 09-03-2017 IPR009000 Translation protein, beta-barrel domain TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 SMART SM00838 615 702 1.9E-58 T 09-03-2017 IPR000640 Translation elongation factor EFG, V domain TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 Pfam PF14492 Elongation Factor G, domain II 417 491 1.5E-33 T 09-03-2017 IPR009022 Elongation factor G, III-V domain TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 Pfam PF00679 Elongation factor G C-terminus 615 701 1.4E-30 T 09-03-2017 IPR000640 Translation elongation factor EFG, V domain TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 SMART SM00889 493 613 1.9E-68 T 09-03-2017 IPR005517 Translation elongation factor EFG/EF2, domain IV GO:0005525 TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 TIGRFAM TIGR00484 EF-G: translation elongation factor G 5 707 0.0 T 09-03-2017 IPR004540 Translation elongation factor EFG/EF2 GO:0003746|GO:0005525|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 Gene3D G3DSA:2.40.30.10 318 417 1.3E-38 T 09-03-2017 TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 SUPERFAMILY SSF54980 618 705 2.25E-30 T 09-03-2017 IPR009022 Elongation factor G, III-V domain TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 Pfam PF00009 Elongation factor Tu GTP binding domain 10 294 8.0E-66 T 09-03-2017 TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 Pfam PF03144 Elongation factor Tu domain 2 337 404 4.2E-15 T 09-03-2017 IPR004161 Translation elongation factor EFTu-like, domain 2 GO:0005525 TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 ProSitePatterns PS00301 Translational (tr)-type guanine nucleotide-binding (G) domain signature. 52 67 - T 09-03-2017 IPR031157 Tr-type G domain, conserved site TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 Hamap MF_00054_B Elongation factor G [fusA]. 7 706 109.775 T 09-03-2017 IPR004540 Translation elongation factor EFG/EF2 GO:0003746|GO:0005525|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 Gene3D G3DSA:3.40.50.300 7 299 3.3E-104 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 Gene3D G3DSA:3.30.70.870 418 493 2.4E-37 T 09-03-2017 TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 Gene3D G3DSA:3.30.230.10 497 612 3.1E-46 T 09-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 PRINTS PR00315 GTP-binding elongation factor signature 13 26 4.2E-16 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 PRINTS PR00315 GTP-binding elongation factor signature 99 110 4.2E-16 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 PRINTS PR00315 GTP-binding elongation factor signature 135 144 4.2E-16 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 PRINTS PR00315 GTP-binding elongation factor signature 83 93 4.2E-16 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 PRINTS PR00315 GTP-binding elongation factor signature 59 67 4.2E-16 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 SUPERFAMILY SSF52540 7 294 1.28E-104 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 Pfam PF03764 Elongation factor G, domain IV 492 613 1.7E-46 T 09-03-2017 IPR005517 Translation elongation factor EFG/EF2, domain IV GO:0005525 TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 11 184 1.5E-33 T 09-03-2017 IPR005225 Small GTP-binding protein domain GO:0005525 TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 Gene3D G3DSA:3.30.70.240 613 706 4.3E-34 T 09-03-2017 IPR000640 Translation elongation factor EFG, V domain TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 SUPERFAMILY SSF54980 417 494 5.4E-25 T 09-03-2017 IPR009022 Elongation factor G, III-V domain TK78_RS13200 bdd97ff73977ce1fb082b7c9f195a17a 709 SUPERFAMILY SSF54211 492 614 1.01E-39 T 09-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold TK78_RS10405 6652657b05bf9ff599476c8ddc5e6520 216 SUPERFAMILY SSF55166 20 207 2.04E-39 T 09-03-2017 IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain Reactome: R-HSA-373080|Reactome: R-HSA-5358346|Reactome: R-HSA-5362798|Reactome: R-HSA-5632681|Reactome: R-HSA-5658034 TK78_RS10405 6652657b05bf9ff599476c8ddc5e6520 216 Pfam PF01427 D-ala-D-ala dipeptidase 61 207 1.4E-15 T 09-03-2017 IPR000755 D-alanyl-D-alanine dipeptidase GO:0005618|GO:0006508|GO:0008237|GO:0016805 MetaCyc: PWY-6454|MetaCyc: PWY-6455 TK78_RS10405 6652657b05bf9ff599476c8ddc5e6520 216 PIRSF PIRSF026671 1 213 4.5E-40 T 09-03-2017 IPR000755 D-alanyl-D-alanine dipeptidase GO:0005618|GO:0006508|GO:0008237|GO:0016805 MetaCyc: PWY-6454|MetaCyc: PWY-6455 TK78_RS10405 6652657b05bf9ff599476c8ddc5e6520 216 Gene3D G3DSA:3.30.1380.10 20 208 1.2E-42 T 09-03-2017 IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain Reactome: R-HSA-373080|Reactome: R-HSA-5358346|Reactome: R-HSA-5362798|Reactome: R-HSA-5632681|Reactome: R-HSA-5658034 TK78_RS15885 2d420b806715eaf5ecad0afd129f2e20 543 Pfam PF13556 PucR C-terminal helix-turn-helix domain 369 412 1.7E-8 T 09-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain TK78_RS15885 2d420b806715eaf5ecad0afd129f2e20 543 Pfam PF13556 PucR C-terminal helix-turn-helix domain 478 534 1.5E-12 T 09-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain TK78_RS05125 6ab948502942ca21ff4432e1c3d5eea2 246 SUPERFAMILY SSF51735 8 246 3.4E-75 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS05125 6ab948502942ca21ff4432e1c3d5eea2 246 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 145 173 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS05125 6ab948502942ca21ff4432e1c3d5eea2 246 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 9 195 0.0091 T 09-03-2017 TK78_RS05125 6ab948502942ca21ff4432e1c3d5eea2 246 Gene3D G3DSA:3.40.50.720 8 246 1.1E-75 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS05125 6ab948502942ca21ff4432e1c3d5eea2 246 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 85 96 3.0E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS05125 6ab948502942ca21ff4432e1c3d5eea2 246 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 137 145 3.0E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS05125 6ab948502942ca21ff4432e1c3d5eea2 246 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 158 177 3.0E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS05125 6ab948502942ca21ff4432e1c3d5eea2 246 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 17 246 2.3E-56 T 09-03-2017 TK78_RS05125 6ab948502942ca21ff4432e1c3d5eea2 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 131 147 1.7E-38 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS05125 6ab948502942ca21ff4432e1c3d5eea2 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 179 196 1.7E-38 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS05125 6ab948502942ca21ff4432e1c3d5eea2 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 85 96 1.7E-38 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS05125 6ab948502942ca21ff4432e1c3d5eea2 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 158 177 1.7E-38 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS05125 6ab948502942ca21ff4432e1c3d5eea2 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 10 27 1.7E-38 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS05125 6ab948502942ca21ff4432e1c3d5eea2 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 210 230 1.7E-38 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS12680 5a8b0188e23eff6ecc29f6521bde5708 1050 SUPERFAMILY SSF56112 80 181 5.11E-21 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS12680 5a8b0188e23eff6ecc29f6521bde5708 1050 SUPERFAMILY SSF56112 601 729 5.11E-21 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS12680 5a8b0188e23eff6ecc29f6521bde5708 1050 Gene3D G3DSA:1.10.510.10 598 705 3.4E-23 T 09-03-2017 TK78_RS12680 5a8b0188e23eff6ecc29f6521bde5708 1050 Gene3D G3DSA:1.10.510.10 95 188 3.4E-23 T 09-03-2017 TK78_RS12680 5a8b0188e23eff6ecc29f6521bde5708 1050 Pfam PF00069 Protein kinase domain 89 178 4.9E-7 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS12680 5a8b0188e23eff6ecc29f6521bde5708 1050 SMART SM00220 23 704 5.6E-7 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS15980 6d598fa9f5c4117b71e55b118dec638c 502 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 23 423 6.8E-76 T 09-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 TK78_RS15980 6d598fa9f5c4117b71e55b118dec638c 502 Pfam PF07690 Major Facilitator Superfamily 26 421 8.8E-55 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS15980 6d598fa9f5c4117b71e55b118dec638c 502 PRINTS PR01036 Tetracycline resistance protein TetB signature 115 135 9.3E-5 T 09-03-2017 TK78_RS15980 6d598fa9f5c4117b71e55b118dec638c 502 PRINTS PR01036 Tetracycline resistance protein TetB signature 24 48 9.3E-5 T 09-03-2017 TK78_RS15980 6d598fa9f5c4117b71e55b118dec638c 502 PRINTS PR01036 Tetracycline resistance protein TetB signature 145 169 9.3E-5 T 09-03-2017 TK78_RS15980 6d598fa9f5c4117b71e55b118dec638c 502 SUPERFAMILY SSF103473 255 470 1.31E-70 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS15980 6d598fa9f5c4117b71e55b118dec638c 502 SUPERFAMILY SSF103473 15 204 1.31E-70 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS15980 6d598fa9f5c4117b71e55b118dec638c 502 Gene3D G3DSA:1.20.1250.20 267 481 5.9E-15 T 09-03-2017 TK78_RS15980 6d598fa9f5c4117b71e55b118dec638c 502 Gene3D G3DSA:1.20.1250.20 19 202 2.5E-36 T 09-03-2017 TK78_RS02270 21d5386801e9263371251d0e8a810b8c 190 Gene3D G3DSA:1.10.10.10 111 168 2.1E-16 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS02270 21d5386801e9263371251d0e8a810b8c 190 Pfam PF04545 Sigma-70, region 4 118 163 7.9E-11 T 09-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS02270 21d5386801e9263371251d0e8a810b8c 190 SUPERFAMILY SSF88946 7 97 4.71E-19 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS02270 21d5386801e9263371251d0e8a810b8c 190 Gene3D G3DSA:1.10.1740.10 5 85 2.0E-20 T 09-03-2017 TK78_RS02270 21d5386801e9263371251d0e8a810b8c 190 SUPERFAMILY SSF88659 105 167 2.24E-13 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS02270 21d5386801e9263371251d0e8a810b8c 190 ProSitePatterns PS01063 Sigma-70 factors ECF subfamily signature. 38 70 - T 09-03-2017 IPR000838 RNA polymerase sigma factor 70, ECF, conserved site GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS02270 21d5386801e9263371251d0e8a810b8c 190 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 12 165 4.7E-23 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS02270 21d5386801e9263371251d0e8a810b8c 190 Pfam PF04542 Sigma-70 region 2 17 83 4.6E-16 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS23980 cdd11db2987dcab0c3b88316a91da98e 857 ProSitePatterns PS00211 ABC transporters family signature. 685 699 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS23980 cdd11db2987dcab0c3b88316a91da98e 857 SUPERFAMILY SSF52540 542 777 3.95E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23980 cdd11db2987dcab0c3b88316a91da98e 857 SMART SM00382 581 761 3.2E-17 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS23980 cdd11db2987dcab0c3b88316a91da98e 857 Gene3D G3DSA:2.60.120.260 360 516 2.3E-20 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS23980 cdd11db2987dcab0c3b88316a91da98e 857 SMART SM00939 283 512 5.8E-16 T 09-03-2017 IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal GO:0008239 TK78_RS23980 cdd11db2987dcab0c3b88316a91da98e 857 Gene3D G3DSA:3.40.50.300 545 774 9.3E-64 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23980 cdd11db2987dcab0c3b88316a91da98e 857 Pfam PF02129 X-Pro dipeptidyl-peptidase (S15 family) 29 173 5.2E-19 T 09-03-2017 IPR000383 Xaa-Pro dipeptidyl-peptidase-like domain GO:0016787 TK78_RS23980 cdd11db2987dcab0c3b88316a91da98e 857 Pfam PF08530 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain 387 498 3.9E-13 T 09-03-2017 IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal GO:0008239 TK78_RS23980 cdd11db2987dcab0c3b88316a91da98e 857 Pfam PF00005 ABC transporter 573 713 2.9E-28 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS23980 cdd11db2987dcab0c3b88316a91da98e 857 SUPERFAMILY SSF53474 16 296 2.32E-54 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS23980 cdd11db2987dcab0c3b88316a91da98e 857 Gene3D G3DSA:3.40.50.1820 15 291 1.4E-58 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS23980 cdd11db2987dcab0c3b88316a91da98e 857 SUPERFAMILY SSF49785 324 503 6.8E-21 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS25085 6f1319f14214343f2f8ba5e02dec455e 297 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 138 159 - T 09-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 TK78_RS25085 6f1319f14214343f2f8ba5e02dec455e 297 Gene3D G3DSA:3.40.50.720 143 229 5.2E-14 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS25085 6f1319f14214343f2f8ba5e02dec455e 297 SUPERFAMILY SSF51735 111 293 1.73E-24 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS25085 6f1319f14214343f2f8ba5e02dec455e 297 Pfam PF13602 Zinc-binding dehydrogenase 193 295 3.6E-12 T 09-03-2017 TK78_RS25085 6f1319f14214343f2f8ba5e02dec455e 297 SUPERFAMILY SSF50129 1 147 2.13E-27 T 09-03-2017 IPR011032 GroES-like TK78_RS25085 6f1319f14214343f2f8ba5e02dec455e 297 SMART SM00829 10 295 7.2E-12 T 09-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 TK78_RS25085 6f1319f14214343f2f8ba5e02dec455e 297 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 27 90 2.7E-7 T 09-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 TK78_RS25085 6f1319f14214343f2f8ba5e02dec455e 297 Gene3D G3DSA:3.90.180.10 1 142 5.0E-35 T 09-03-2017 IPR011032 GroES-like TK78_RS13635 261c6c12a5f0e1d6d027441e16f45089 836 Gene3D G3DSA:2.40.40.20 744 800 1.8E-5 T 09-03-2017 TK78_RS13635 261c6c12a5f0e1d6d027441e16f45089 836 Gene3D G3DSA:3.40.50.740 295 363 3.2E-44 T 09-03-2017 TK78_RS13635 261c6c12a5f0e1d6d027441e16f45089 836 Gene3D G3DSA:3.40.50.740 404 441 3.2E-44 T 09-03-2017 TK78_RS13635 261c6c12a5f0e1d6d027441e16f45089 836 Gene3D G3DSA:3.40.50.740 560 696 3.2E-44 T 09-03-2017 TK78_RS13635 261c6c12a5f0e1d6d027441e16f45089 836 SUPERFAMILY SSF53706 229 699 1.68E-79 T 09-03-2017 TK78_RS13635 261c6c12a5f0e1d6d027441e16f45089 836 Gene3D G3DSA:3.10.20.30 22 76 3.1E-6 T 09-03-2017 IPR012675 Beta-grasp domain TK78_RS13635 261c6c12a5f0e1d6d027441e16f45089 836 Pfam PF04879 Molybdopterin oxidoreductase Fe4S4 domain 240 290 4.0E-6 T 09-03-2017 IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13635 261c6c12a5f0e1d6d027441e16f45089 836 Pfam PF01568 Molydopterin dinucleotide binding domain 747 814 4.7E-7 T 09-03-2017 IPR006657 Molybdopterin dinucleotide-binding domain GO:0016491|GO:0030151|GO:0055114 TK78_RS13635 261c6c12a5f0e1d6d027441e16f45089 836 ProSitePatterns PS00643 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. 168 178 - T 09-03-2017 IPR000283 NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site GO:0008137|GO:0016020|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13635 261c6c12a5f0e1d6d027441e16f45089 836 Gene3D G3DSA:2.20.25.90 241 291 1.3E-10 T 09-03-2017 TK78_RS13635 261c6c12a5f0e1d6d027441e16f45089 836 SUPERFAMILY SSF54862 98 233 7.11E-32 T 09-03-2017 TK78_RS13635 261c6c12a5f0e1d6d027441e16f45089 836 SUPERFAMILY SSF54292 22 93 1.57E-19 T 09-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 TK78_RS13635 261c6c12a5f0e1d6d027441e16f45089 836 SUPERFAMILY SSF50692 743 823 8.36E-8 T 09-03-2017 IPR009010 Aspartate decarboxylase-like domain TK78_RS13635 261c6c12a5f0e1d6d027441e16f45089 836 Gene3D G3DSA:3.30.70.20 159 225 6.3E-4 T 09-03-2017 TK78_RS13635 261c6c12a5f0e1d6d027441e16f45089 836 Pfam PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 105 143 2.7E-16 T 09-03-2017 IPR019574 NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13635 261c6c12a5f0e1d6d027441e16f45089 836 Pfam PF00384 Molybdopterin oxidoreductase 575 657 3.1E-8 T 09-03-2017 IPR006656 Molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13635 261c6c12a5f0e1d6d027441e16f45089 836 Pfam PF00384 Molybdopterin oxidoreductase 295 439 1.3E-11 T 09-03-2017 IPR006656 Molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13635 261c6c12a5f0e1d6d027441e16f45089 836 Pfam PF13510 2Fe-2S iron-sulfur cluster binding domain 20 95 5.4E-19 T 09-03-2017 TK78_RS13635 261c6c12a5f0e1d6d027441e16f45089 836 ProSitePatterns PS00641 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. 51 68 - T 09-03-2017 IPR000283 NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site GO:0008137|GO:0016020|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13635 261c6c12a5f0e1d6d027441e16f45089 836 SMART SM00929 105 145 7.9E-20 T 09-03-2017 IPR019574 NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13635 261c6c12a5f0e1d6d027441e16f45089 836 SMART SM00926 238 292 5.5E-7 T 09-03-2017 IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13635 261c6c12a5f0e1d6d027441e16f45089 836 TIGRFAM TIGR01973 NuoG: NADH dehydrogenase (quinone), G subunit 24 674 9.6E-195 T 09-03-2017 IPR010228 NADH:ubiquinone oxidoreductase, subunit G GO:0016651|GO:0051536|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13635 261c6c12a5f0e1d6d027441e16f45089 836 ProSitePatterns PS00642 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. 120 132 - T 09-03-2017 IPR000283 NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site GO:0008137|GO:0016020|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS12685 d4b3ca2c31112b9254173ef9fa3727a0 712 Gene3D G3DSA:1.10.510.10 93 280 5.4E-42 T 09-03-2017 TK78_RS12685 d4b3ca2c31112b9254173ef9fa3727a0 712 SUPERFAMILY SSF56112 20 284 6.74E-64 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS12685 d4b3ca2c31112b9254173ef9fa3727a0 712 Pfam PF00069 Protein kinase domain 23 269 3.5E-44 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS12685 d4b3ca2c31112b9254173ef9fa3727a0 712 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 146 158 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS12685 d4b3ca2c31112b9254173ef9fa3727a0 712 SMART SM00220 23 281 2.5E-53 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS12685 d4b3ca2c31112b9254173ef9fa3727a0 712 Gene3D G3DSA:3.30.200.20 14 92 9.3E-23 T 09-03-2017 TK78_RS12685 d4b3ca2c31112b9254173ef9fa3727a0 712 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 29 52 - T 09-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 TK78_RS00470 bc9e55394a1ebce39b41e2020e86c27d 429 Gene3D G3DSA:3.40.190.10 55 173 2.4E-9 T 09-03-2017 TK78_RS00470 bc9e55394a1ebce39b41e2020e86c27d 429 Gene3D G3DSA:3.40.190.10 174 354 6.0E-17 T 09-03-2017 TK78_RS00470 bc9e55394a1ebce39b41e2020e86c27d 429 SUPERFAMILY SSF53850 26 424 1.47E-38 T 09-03-2017 TK78_RS00470 bc9e55394a1ebce39b41e2020e86c27d 429 Pfam PF01547 Bacterial extracellular solute-binding protein 51 347 1.1E-25 T 09-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 TK78_RS22065 aff6a1371ecaf3e34ea53f36855700b6 416 Pfam PF14258 Domain of unknown function (DUF4350) 56 126 6.2E-12 T 09-03-2017 IPR025646 Domain of unknown function DUF4350 TK78_RS07045 6e49d7811f6d1317fed8bd463cdb82a7 449 SUPERFAMILY SSF102114 152 366 2.35E-6 T 09-03-2017 TK78_RS20975 e0daf1116f282e418ceace213daad784 502 SUPERFAMILY SSF55797 382 496 1.64E-18 T 09-03-2017 IPR014044 CAP domain TK78_RS20975 e0daf1116f282e418ceace213daad784 502 Pfam PF00188 Cysteine-rich secretory protein family 384 497 4.6E-15 T 09-03-2017 IPR014044 CAP domain TK78_RS20975 e0daf1116f282e418ceace213daad784 502 ProSitePatterns PS01063 Sigma-70 factors ECF subfamily signature. 46 77 - T 09-03-2017 IPR000838 RNA polymerase sigma factor 70, ECF, conserved site GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS20975 e0daf1116f282e418ceace213daad784 502 Pfam PF04542 Sigma-70 region 2 24 87 8.6E-13 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS20975 e0daf1116f282e418ceace213daad784 502 Gene3D G3DSA:1.10.1740.10 6 106 7.2E-22 T 09-03-2017 TK78_RS20975 e0daf1116f282e418ceace213daad784 502 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 22 179 8.4E-19 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS20975 e0daf1116f282e418ceace213daad784 502 Gene3D G3DSA:3.40.33.10 381 491 8.6E-11 T 09-03-2017 IPR014044 CAP domain TK78_RS20975 e0daf1116f282e418ceace213daad784 502 SUPERFAMILY SSF88946 4 103 9.58E-21 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS20975 e0daf1116f282e418ceace213daad784 502 Gene3D G3DSA:1.10.10.10 136 177 6.8E-4 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS09510 4707d379ce2827da9e4363f93d729330 216 SUPERFAMILY SSF51219 7 213 4.71E-47 T 09-03-2017 IPR016031 Tryptophan RNA-binding attenuator protein-like domain TK78_RS09510 4707d379ce2827da9e4363f93d729330 216 Gene3D G3DSA:3.60.160.10 8 211 1.2E-46 T 09-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 TK78_RS09510 4707d379ce2827da9e4363f93d729330 216 Pfam PF01987 Mitochondrial biogenesis AIM24 7 211 5.0E-36 T 09-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 TK78_RS21160 801139efb64aa59576521bf6375ba59e 293 Gene3D G3DSA:3.40.1010.10 9 119 1.1E-7 T 09-03-2017 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS21160 801139efb64aa59576521bf6375ba59e 293 Gene3D G3DSA:3.30.950.10 120 231 1.3E-43 T 09-03-2017 IPR014776 Tetrapyrrole methylase, subdomain 2 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS21160 801139efb64aa59576521bf6375ba59e 293 PIRSF PIRSF005917 2 286 2.4E-90 T 09-03-2017 IPR008189 rRNA small subunit methyltransferase I GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 TK78_RS21160 801139efb64aa59576521bf6375ba59e 293 SUPERFAMILY SSF53790 9 228 1.28E-73 T 09-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS21160 801139efb64aa59576521bf6375ba59e 293 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 10 213 2.6E-30 T 09-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS21160 801139efb64aa59576521bf6375ba59e 293 TIGRFAM TIGR00096 TIGR00096: 16S rRNA (cytidine(1402)-2'-O)-methyltransferase 12 278 3.1E-62 T 09-03-2017 IPR008189 rRNA small subunit methyltransferase I GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 TK78_RS21160 801139efb64aa59576521bf6375ba59e 293 Hamap MF_01877 Ribosomal RNA small subunit methyltransferase I [rsmI]. 10 230 33.014 T 09-03-2017 IPR008189 rRNA small subunit methyltransferase I GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 TK78_RS33405 838b45d3d71d8199d6e07188f1a7aa78 220 Gene3D G3DSA:1.10.10.60 8 60 2.0E-16 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS33405 838b45d3d71d8199d6e07188f1a7aa78 220 Pfam PF00440 Bacterial regulatory proteins, tetR family 24 63 7.0E-12 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS33405 838b45d3d71d8199d6e07188f1a7aa78 220 SUPERFAMILY SSF46689 9 90 5.67E-15 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS33405 838b45d3d71d8199d6e07188f1a7aa78 220 Gene3D G3DSA:1.10.357.10 61 201 3.6E-21 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS33205 f2297fd8b05cc0e2f75598afaed98a17 177 Pfam PF13202 EF hand 65 82 4.9E-6 T 09-03-2017 IPR002048 EF-hand domain GO:0005509 TK78_RS33205 f2297fd8b05cc0e2f75598afaed98a17 177 Gene3D G3DSA:1.10.238.10 5 165 3.1E-20 T 09-03-2017 IPR011992 EF-hand domain pair TK78_RS33205 f2297fd8b05cc0e2f75598afaed98a17 177 ProSitePatterns PS00018 EF-hand calcium-binding domain. 67 79 - T 09-03-2017 IPR018247 EF-Hand 1, calcium-binding site TK78_RS33205 f2297fd8b05cc0e2f75598afaed98a17 177 SMART SM00054 96 124 18.0 T 09-03-2017 IPR002048 EF-hand domain GO:0005509 TK78_RS33205 f2297fd8b05cc0e2f75598afaed98a17 177 SMART SM00054 58 86 0.36 T 09-03-2017 IPR002048 EF-hand domain GO:0005509 TK78_RS33205 f2297fd8b05cc0e2f75598afaed98a17 177 SMART SM00054 8 36 8.8 T 09-03-2017 IPR002048 EF-hand domain GO:0005509 TK78_RS33205 f2297fd8b05cc0e2f75598afaed98a17 177 ProSitePatterns PS00018 EF-hand calcium-binding domain. 17 29 - T 09-03-2017 IPR018247 EF-Hand 1, calcium-binding site TK78_RS33205 f2297fd8b05cc0e2f75598afaed98a17 177 SUPERFAMILY SSF47473 4 159 5.73E-20 T 09-03-2017 IPR011992 EF-hand domain pair TK78_RS17825 cef9ce982d4cca0cb3893d89620bebaa 597 Pfam PF00152 tRNA synthetases class II (D, K and N) 122 555 1.0E-91 T 09-03-2017 IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N) GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS17825 cef9ce982d4cca0cb3893d89620bebaa 597 Pfam PF02938 GAD domain 315 403 3.4E-20 T 09-03-2017 IPR029351 GAD domain Reactome: R-HSA-379726 TK78_RS17825 cef9ce982d4cca0cb3893d89620bebaa 597 SUPERFAMILY SSF55261 297 414 1.23E-33 T 09-03-2017 IPR004115 GAD-like domain GO:0004812|GO:0005524|GO:0005737 Reactome: R-HSA-379726 TK78_RS17825 cef9ce982d4cca0cb3893d89620bebaa 597 Pfam PF01336 OB-fold nucleic acid binding domain 21 104 1.4E-14 T 09-03-2017 IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type GO:0003676 TK78_RS17825 cef9ce982d4cca0cb3893d89620bebaa 597 SUPERFAMILY SSF55681 117 298 5.97E-92 T 09-03-2017 TK78_RS17825 cef9ce982d4cca0cb3893d89620bebaa 597 SUPERFAMILY SSF55681 422 583 5.97E-92 T 09-03-2017 TK78_RS17825 cef9ce982d4cca0cb3893d89620bebaa 597 Gene3D G3DSA:3.30.930.10 136 282 1.6E-95 T 09-03-2017 TK78_RS17825 cef9ce982d4cca0cb3893d89620bebaa 597 Gene3D G3DSA:3.30.930.10 411 583 1.6E-95 T 09-03-2017 TK78_RS17825 cef9ce982d4cca0cb3893d89620bebaa 597 TIGRFAM TIGR00459 aspS_bact: aspartate--tRNA ligase 5 582 3.2E-183 T 09-03-2017 IPR004524 Aspartate-tRNA ligase, bacterial/mitochondrial-type GO:0005524|GO:0016874 Reactome: R-HSA-379726 TK78_RS17825 cef9ce982d4cca0cb3893d89620bebaa 597 Gene3D G3DSA:3.30.1360.30 283 410 9.6E-40 T 09-03-2017 IPR004115 GAD-like domain GO:0004812|GO:0005524|GO:0005737 Reactome: R-HSA-379726 TK78_RS17825 cef9ce982d4cca0cb3893d89620bebaa 597 Gene3D G3DSA:2.40.50.140 4 108 1.8E-34 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS17825 cef9ce982d4cca0cb3893d89620bebaa 597 Hamap MF_00044 Aspartate--tRNA(Asp) ligase [aspS]. 4 561 32.915 T 09-03-2017 TK78_RS17825 cef9ce982d4cca0cb3893d89620bebaa 597 SUPERFAMILY SSF50249 4 107 2.48E-28 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS17825 cef9ce982d4cca0cb3893d89620bebaa 597 PRINTS PR01042 Aspartyl-tRNA synthetase signature 194 206 1.1E-20 T 09-03-2017 IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS17825 cef9ce982d4cca0cb3893d89620bebaa 597 PRINTS PR01042 Aspartyl-tRNA synthetase signature 211 224 1.1E-20 T 09-03-2017 IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS17825 cef9ce982d4cca0cb3893d89620bebaa 597 PRINTS PR01042 Aspartyl-tRNA synthetase signature 472 488 1.1E-20 T 09-03-2017 IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS17825 cef9ce982d4cca0cb3893d89620bebaa 597 PRINTS PR01042 Aspartyl-tRNA synthetase signature 516 530 1.1E-20 T 09-03-2017 IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS33390 d2918b707a347c9b91907941a424ce30 293 SUPERFAMILY SSF88659 214 289 4.49E-17 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS33390 d2918b707a347c9b91907941a424ce30 293 Gene3D G3DSA:1.10.601.10 30 133 4.4E-25 T 09-03-2017 TK78_RS33390 d2918b707a347c9b91907941a424ce30 293 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 61 287 4.2E-34 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS33390 d2918b707a347c9b91907941a424ce30 293 SUPERFAMILY SSF88659 139 204 2.53E-12 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS33390 d2918b707a347c9b91907941a424ce30 293 TIGRFAM TIGR02980 SigBFG: RNA polymerase sigma-70 factor, sigma-B/F/G subfamily 59 289 1.4E-86 T 09-03-2017 IPR014322 RNA polymerase sigma-B/F/G type GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS33390 d2918b707a347c9b91907941a424ce30 293 SUPERFAMILY SSF88946 19 135 4.55E-31 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS33390 d2918b707a347c9b91907941a424ce30 293 Gene3D G3DSA:1.10.10.10 235 288 1.1E-11 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS33390 d2918b707a347c9b91907941a424ce30 293 ProSitePatterns PS00715 Sigma-70 factors family signature 1. 90 103 - T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS33390 d2918b707a347c9b91907941a424ce30 293 Pfam PF04545 Sigma-70, region 4 238 287 4.0E-18 T 09-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS33390 d2918b707a347c9b91907941a424ce30 293 Pfam PF04539 Sigma-70 region 3 145 198 3.5E-9 T 09-03-2017 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS33390 d2918b707a347c9b91907941a424ce30 293 Gene3D G3DSA:1.10.10.10 134 189 5.3E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS33390 d2918b707a347c9b91907941a424ce30 293 Pfam PF04542 Sigma-70 region 2 65 135 2.5E-16 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS33390 d2918b707a347c9b91907941a424ce30 293 PRINTS PR00046 Major sigma-70 factor signature 90 103 3.0E-11 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS33390 d2918b707a347c9b91907941a424ce30 293 PRINTS PR00046 Major sigma-70 factor signature 242 254 3.0E-11 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS33390 d2918b707a347c9b91907941a424ce30 293 PRINTS PR00046 Major sigma-70 factor signature 259 274 3.0E-11 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS33390 d2918b707a347c9b91907941a424ce30 293 PRINTS PR00046 Major sigma-70 factor signature 274 285 3.0E-11 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS31785 2dbfffd04fc048bd13e5b712ae73f8b7 605 Gene3D G3DSA:3.40.50.300 360 591 9.5E-80 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31785 2dbfffd04fc048bd13e5b712ae73f8b7 605 SUPERFAMILY SSF52540 349 594 1.81E-91 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31785 2dbfffd04fc048bd13e5b712ae73f8b7 605 Gene3D G3DSA:1.20.1560.10 26 339 2.9E-67 T 09-03-2017 TK78_RS31785 2dbfffd04fc048bd13e5b712ae73f8b7 605 Pfam PF00664 ABC transporter transmembrane region 43 313 9.1E-36 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS31785 2dbfffd04fc048bd13e5b712ae73f8b7 605 SMART SM00382 386 572 2.0E-13 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS31785 2dbfffd04fc048bd13e5b712ae73f8b7 605 ProSitePatterns PS00211 ABC transporters family signature. 498 512 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS31785 2dbfffd04fc048bd13e5b712ae73f8b7 605 Pfam PF00005 ABC transporter 377 526 1.1E-28 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS31785 2dbfffd04fc048bd13e5b712ae73f8b7 605 SUPERFAMILY SSF90123 22 341 3.27E-66 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS31570 1ea61d7e143c0ec7e174fc0a503f9c6a 313 Gene3D G3DSA:1.10.10.10 3 87 5.1E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS31570 1ea61d7e143c0ec7e174fc0a503f9c6a 313 Gene3D G3DSA:3.40.190.10 183 272 1.9E-20 T 09-03-2017 TK78_RS31570 1ea61d7e143c0ec7e174fc0a503f9c6a 313 Gene3D G3DSA:3.40.190.10 92 182 4.9E-18 T 09-03-2017 TK78_RS31570 1ea61d7e143c0ec7e174fc0a503f9c6a 313 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 6 63 1.1E-19 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS31570 1ea61d7e143c0ec7e174fc0a503f9c6a 313 SUPERFAMILY SSF53850 92 300 8.69E-39 T 09-03-2017 TK78_RS31570 1ea61d7e143c0ec7e174fc0a503f9c6a 313 SUPERFAMILY SSF46785 1 111 1.47E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS31570 1ea61d7e143c0ec7e174fc0a503f9c6a 313 Pfam PF03466 LysR substrate binding domain 90 297 8.7E-43 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS23940 201c0ae5ff7314f65250b902871a390b 289 SUPERFAMILY SSF51182 11 250 1.1E-55 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS23940 201c0ae5ff7314f65250b902871a390b 289 Pfam PF04962 KduI/IolB family 6 261 3.5E-83 T 09-03-2017 IPR021120 KduI/IolB isomerase GO:0016861 KEGG: 00040+5.3.1.17|MetaCyc: PWY-6507 TK78_RS23940 201c0ae5ff7314f65250b902871a390b 289 PIRSF PIRSF036628 3 267 8.8E-96 T 09-03-2017 IPR024203 5-deoxy-glucuronate isomerase, IolB GO:0008880|GO:0019310 KEGG: 00562+5.3.1.30 TK78_RS23940 201c0ae5ff7314f65250b902871a390b 289 Gene3D G3DSA:2.60.120.10 12 113 3.8E-26 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS23940 201c0ae5ff7314f65250b902871a390b 289 TIGRFAM TIGR04378 myo_inos_iolB: 5-deoxy-glucuronate isomerase 14 262 1.9E-81 T 09-03-2017 IPR024203 5-deoxy-glucuronate isomerase, IolB GO:0008880|GO:0019310 KEGG: 00562+5.3.1.30 TK78_RS23940 201c0ae5ff7314f65250b902871a390b 289 Gene3D G3DSA:2.60.120.10 114 267 1.7E-63 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS30710 4e385f760fbab51995f7e088f8f41b84 659 Gene3D G3DSA:3.40.50.980 278 442 7.7E-15 T 09-03-2017 TK78_RS30710 4e385f760fbab51995f7e088f8f41b84 659 Pfam PF13193 AMP-binding enzyme C-terminal domain 542 617 4.1E-7 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS30710 4e385f760fbab51995f7e088f8f41b84 659 Pfam PF00501 AMP-binding enzyme 108 529 1.1E-44 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS30710 4e385f760fbab51995f7e088f8f41b84 659 ProSitePatterns PS00455 Putative AMP-binding domain signature. 272 283 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS30710 4e385f760fbab51995f7e088f8f41b84 659 TIGRFAM TIGR01217 ac_ac_CoA_syn: acetoacetate-CoA ligase 8 657 0.0 T 09-03-2017 IPR005914 Acetoacetyl-CoA synthase GO:0006629|GO:0030729 KEGG: 00280+6.2.1.16|KEGG: 00650+6.2.1.16|Reactome: R-HSA-77111 TK78_RS30710 4e385f760fbab51995f7e088f8f41b84 659 Pfam PF16177 Acetyl-coenzyme A synthetase N-terminus 42 98 9.5E-14 T 09-03-2017 IPR032387 Acetyl-coenzyme A synthetase, N-terminal domain KEGG: 00010+6.2.1.1|KEGG: 00620+6.2.1.1|KEGG: 00640+6.2.1.1|KEGG: 00680+6.2.1.1|KEGG: 00720+6.2.1.1|MetaCyc: PWY-6672|MetaCyc: PWY-7118 TK78_RS30710 4e385f760fbab51995f7e088f8f41b84 659 Gene3D G3DSA:3.30.300.30 528 618 1.9E-13 T 09-03-2017 TK78_RS30710 4e385f760fbab51995f7e088f8f41b84 659 SUPERFAMILY SSF56801 41 631 1.44E-125 T 09-03-2017 TK78_RS30710 4e385f760fbab51995f7e088f8f41b84 659 Gene3D G3DSA:3.40.50.980 108 277 2.0E-27 T 09-03-2017 TK78_RS23735 b1ee4e0f187fbd3b0f1206c9aa43aa3e 1116 SUPERFAMILY SSF55073 47 236 9.89E-48 T 09-03-2017 IPR029787 Nucleotide cyclase TK78_RS23735 b1ee4e0f187fbd3b0f1206c9aa43aa3e 1116 SUPERFAMILY SSF52540 245 313 7.58E-7 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23735 b1ee4e0f187fbd3b0f1206c9aa43aa3e 1116 SUPERFAMILY SSF52540 393 456 7.58E-7 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23735 b1ee4e0f187fbd3b0f1206c9aa43aa3e 1116 Gene3D G3DSA:3.30.70.1230 50 225 7.7E-37 T 09-03-2017 IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase GO:0009190|GO:0016849|GO:0035556 TK78_RS23735 b1ee4e0f187fbd3b0f1206c9aa43aa3e 1116 Gene3D G3DSA:1.25.40.10 804 859 2.7E-12 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS23735 b1ee4e0f187fbd3b0f1206c9aa43aa3e 1116 Gene3D G3DSA:1.25.40.10 900 1082 2.7E-12 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS23735 b1ee4e0f187fbd3b0f1206c9aa43aa3e 1116 Gene3D G3DSA:1.25.40.10 708 767 2.7E-12 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS23735 b1ee4e0f187fbd3b0f1206c9aa43aa3e 1116 SUPERFAMILY SSF48452 704 780 4.11E-7 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS23735 b1ee4e0f187fbd3b0f1206c9aa43aa3e 1116 SUPERFAMILY SSF48452 812 870 4.11E-7 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS23735 b1ee4e0f187fbd3b0f1206c9aa43aa3e 1116 SMART SM00044 26 211 1.4E-15 T 09-03-2017 IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase GO:0009190|GO:0016849|GO:0035556 TK78_RS23735 b1ee4e0f187fbd3b0f1206c9aa43aa3e 1116 Pfam PF00211 Adenylate and Guanylate cyclase catalytic domain 52 226 2.3E-26 T 09-03-2017 IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase GO:0009190|GO:0016849|GO:0035556 TK78_RS23735 b1ee4e0f187fbd3b0f1206c9aa43aa3e 1116 Pfam PF13191 AAA ATPase domain 246 427 9.2E-17 T 09-03-2017 TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 Pfam PF00702 haloacid dehalogenase-like hydrolase 354 647 1.0E-15 T 09-03-2017 TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 SUPERFAMILY SSF81665 37 139 4.97E-65 T 09-03-2017 TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 SUPERFAMILY SSF81665 258 352 4.97E-65 T 09-03-2017 TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 SUPERFAMILY SSF81665 682 888 4.97E-65 T 09-03-2017 TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 PRINTS PR01836 Magnesium-transporting ATPase signature 761 777 3.5E-30 T 09-03-2017 IPR006415 P-type ATPase, subfamily IIIB GO:0015444|GO:0015693|GO:0016021 TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 PRINTS PR01836 Magnesium-transporting ATPase signature 287 306 3.5E-30 T 09-03-2017 IPR006415 P-type ATPase, subfamily IIIB GO:0015444|GO:0015693|GO:0016021 TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 PRINTS PR01836 Magnesium-transporting ATPase signature 709 720 3.5E-30 T 09-03-2017 IPR006415 P-type ATPase, subfamily IIIB GO:0015444|GO:0015693|GO:0016021 TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 PRINTS PR01836 Magnesium-transporting ATPase signature 797 818 3.5E-30 T 09-03-2017 IPR006415 P-type ATPase, subfamily IIIB GO:0015444|GO:0015693|GO:0016021 TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 PRINTS PR01836 Magnesium-transporting ATPase signature 691 706 3.5E-30 T 09-03-2017 IPR006415 P-type ATPase, subfamily IIIB GO:0015444|GO:0015693|GO:0016021 TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 PRINTS PR01836 Magnesium-transporting ATPase signature 846 867 3.5E-30 T 09-03-2017 IPR006415 P-type ATPase, subfamily IIIB GO:0015444|GO:0015693|GO:0016021 TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 PRINTS PR01836 Magnesium-transporting ATPase signature 270 286 3.5E-30 T 09-03-2017 IPR006415 P-type ATPase, subfamily IIIB GO:0015444|GO:0015693|GO:0016021 TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 TIGRFAM TIGR01524 ATPase-IIIB_Mg: magnesium-translocating P-type ATPase 38 889 9.4E-204 T 09-03-2017 IPR006415 P-type ATPase, subfamily IIIB GO:0015444|GO:0015693|GO:0016021 TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 SUPERFAMILY SSF56784 479 732 1.02E-38 T 09-03-2017 IPR023214 HAD-like domain TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 SUPERFAMILY SSF56784 356 376 1.02E-38 T 09-03-2017 IPR023214 HAD-like domain TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 Gene3D G3DSA:2.70.150.10 134 252 7.8E-29 T 09-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 Gene3D G3DSA:2.70.150.10 46 80 7.8E-29 T 09-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 SMART SM00831 27 101 4.3E-10 T 09-03-2017 IPR004014 Cation-transporting P-type ATPase, N-terminal Reactome: R-HSA-936837 TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 599 722 1.2E-25 T 09-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 Pfam PF00689 Cation transporting ATPase, C-terminus 716 867 5.2E-9 T 09-03-2017 IPR006068 Cation-transporting P-type ATPase, C-terminal Reactome: R-HSA-936837 TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 SUPERFAMILY SSF81653 154 253 4.05E-22 T 09-03-2017 TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 ProSitePatterns PS00154 E1-E2 ATPases phosphorylation site. 360 366 - T 09-03-2017 IPR018303 P-type ATPase, phosphorylation site Reactome: R-HSA-936837 TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 Gene3D G3DSA:3.40.1110.10 351 533 4.4E-22 T 09-03-2017 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 Reactome: R-HSA-936837 TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 Pfam PF00122 E1-E2 ATPase 107 348 6.1E-45 T 09-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 Pfam PF00690 Cation transporter/ATPase, N-terminus 36 96 2.3E-11 T 09-03-2017 IPR004014 Cation-transporting P-type ATPase, N-terminal Reactome: R-HSA-936837 TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 SUPERFAMILY SSF81660 364 537 5.07E-20 T 09-03-2017 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 Reactome: R-HSA-936837 TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 Gene3D G3DSA:1.20.1110.10 81 133 3.1E-53 T 09-03-2017 IPR023298 P-type ATPase, transmembrane domain Reactome: R-HSA-936837 TK78_RS00980 4c1611ca4ca5455ce493a2a641f8d29d 913 Gene3D G3DSA:1.20.1110.10 602 864 3.1E-53 T 09-03-2017 IPR023298 P-type ATPase, transmembrane domain Reactome: R-HSA-936837 TK78_RS03370 2777cc99d043844a3aecb94ca4b680a0 543 SUPERFAMILY SSF52540 20 222 8.33E-43 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03370 2777cc99d043844a3aecb94ca4b680a0 543 SMART SM00382 32 217 1.1E-12 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS03370 2777cc99d043844a3aecb94ca4b680a0 543 SMART SM00382 364 537 9.2E-12 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS03370 2777cc99d043844a3aecb94ca4b680a0 543 Gene3D G3DSA:3.40.50.300 362 519 1.6E-28 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03370 2777cc99d043844a3aecb94ca4b680a0 543 Gene3D G3DSA:3.40.50.300 9 255 3.3E-44 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03370 2777cc99d043844a3aecb94ca4b680a0 543 ProSitePatterns PS00211 ABC transporters family signature. 145 159 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS03370 2777cc99d043844a3aecb94ca4b680a0 543 Pfam PF00005 ABC transporter 35 173 1.1E-19 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS03370 2777cc99d043844a3aecb94ca4b680a0 543 Pfam PF00005 ABC transporter 365 485 6.6E-17 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS03370 2777cc99d043844a3aecb94ca4b680a0 543 SUPERFAMILY SSF52540 360 516 1.23E-31 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07075 d96d592518001252ffd3798d3938e8ef 398 SUPERFAMILY SSF48264 20 398 1.01E-96 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS07075 d96d592518001252ffd3798d3938e8ef 398 PRINTS PR00359 B-class P450 signature 347 358 1.9E-58 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS07075 d96d592518001252ffd3798d3938e8ef 398 PRINTS PR00359 B-class P450 signature 188 210 1.9E-58 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS07075 d96d592518001252ffd3798d3938e8ef 398 PRINTS PR00359 B-class P450 signature 86 97 1.9E-58 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS07075 d96d592518001252ffd3798d3938e8ef 398 PRINTS PR00359 B-class P450 signature 289 316 1.9E-58 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS07075 d96d592518001252ffd3798d3938e8ef 398 PRINTS PR00359 B-class P450 signature 150 165 1.9E-58 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS07075 d96d592518001252ffd3798d3938e8ef 398 PRINTS PR00359 B-class P450 signature 270 281 1.9E-58 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS07075 d96d592518001252ffd3798d3938e8ef 398 PRINTS PR00359 B-class P450 signature 133 149 1.9E-58 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS07075 d96d592518001252ffd3798d3938e8ef 398 PRINTS PR00359 B-class P450 signature 317 332 1.9E-58 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS07075 d96d592518001252ffd3798d3938e8ef 398 PRINTS PR00359 B-class P450 signature 338 347 1.9E-58 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS07075 d96d592518001252ffd3798d3938e8ef 398 Gene3D G3DSA:1.10.630.10 19 398 1.6E-122 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS07075 d96d592518001252ffd3798d3938e8ef 398 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 340 349 - T 09-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 TK78_RS07075 d96d592518001252ffd3798d3938e8ef 398 Pfam PF00067 Cytochrome P450 186 365 3.1E-24 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS07075 d96d592518001252ffd3798d3938e8ef 398 PRINTS PR00385 P450 superfamily signature 270 281 6.0E-8 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS07075 d96d592518001252ffd3798d3938e8ef 398 PRINTS PR00385 P450 superfamily signature 338 347 6.0E-8 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS07075 d96d592518001252ffd3798d3938e8ef 398 PRINTS PR00385 P450 superfamily signature 347 358 6.0E-8 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS07075 d96d592518001252ffd3798d3938e8ef 398 PRINTS PR00385 P450 superfamily signature 235 252 6.0E-8 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS04950 191653bf25e94bc01a09040c10c5babd 330 SMART SM00060 40 115 4.0E-9 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS04950 191653bf25e94bc01a09040c10c5babd 330 SMART SM00060 232 318 12.0 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS04950 191653bf25e94bc01a09040c10c5babd 330 SMART SM00060 137 213 2.8E-8 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS04950 191653bf25e94bc01a09040c10c5babd 330 SUPERFAMILY SSF49265 135 326 1.12E-16 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS04950 191653bf25e94bc01a09040c10c5babd 330 Gene3D G3DSA:2.60.40.10 249 327 1.7E-5 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS04950 191653bf25e94bc01a09040c10c5babd 330 Gene3D G3DSA:2.60.40.10 38 126 8.4E-21 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS04950 191653bf25e94bc01a09040c10c5babd 330 Gene3D G3DSA:2.60.40.10 135 219 3.3E-18 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS04950 191653bf25e94bc01a09040c10c5babd 330 Pfam PF00041 Fibronectin type III domain 42 116 6.4E-11 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS04950 191653bf25e94bc01a09040c10c5babd 330 Pfam PF00041 Fibronectin type III domain 140 208 9.7E-8 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS04950 191653bf25e94bc01a09040c10c5babd 330 SUPERFAMILY SSF49265 37 132 7.61E-18 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS22365 2ebff3ea2825ba479c2a9b4399146df7 292 SUPERFAMILY SSF46689 235 283 7.62E-9 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS22365 2ebff3ea2825ba479c2a9b4399146df7 292 Gene3D G3DSA:2.60.120.280 38 126 7.3E-8 T 09-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 TK78_RS22365 2ebff3ea2825ba479c2a9b4399146df7 292 SUPERFAMILY SSF46689 186 233 1.52E-5 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS22365 2ebff3ea2825ba479c2a9b4399146df7 292 SMART SM00342 199 281 6.1E-22 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS22365 2ebff3ea2825ba479c2a9b4399146df7 292 Pfam PF12833 Helix-turn-helix domain 206 282 2.1E-18 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS22365 2ebff3ea2825ba479c2a9b4399146df7 292 SUPERFAMILY SSF51215 24 156 3.27E-13 T 09-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 TK78_RS22365 2ebff3ea2825ba479c2a9b4399146df7 292 Gene3D G3DSA:1.10.10.60 237 283 5.4E-9 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS22365 2ebff3ea2825ba479c2a9b4399146df7 292 Gene3D G3DSA:1.10.10.60 179 236 3.0E-11 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS22365 2ebff3ea2825ba479c2a9b4399146df7 292 Pfam PF02311 AraC-like ligand binding domain 37 158 1.9E-20 T 09-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 TK78_RS14240 1b1abadefe782b71a583bb478025d879 243 SUPERFAMILY SSF55811 93 221 3.66E-24 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS14240 1b1abadefe782b71a583bb478025d879 243 PRINTS PR00502 NUDIX hydrolase family signature 138 153 8.2E-8 T 09-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 TK78_RS14240 1b1abadefe782b71a583bb478025d879 243 PRINTS PR00502 NUDIX hydrolase family signature 124 138 8.2E-8 T 09-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 TK78_RS14240 1b1abadefe782b71a583bb478025d879 243 Pfam PF00293 NUDIX domain 97 208 1.6E-15 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS14240 1b1abadefe782b71a583bb478025d879 243 Gene3D G3DSA:3.90.79.10 95 220 8.3E-26 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS14240 1b1abadefe782b71a583bb478025d879 243 ProSitePatterns PS00893 Nudix box signature. 129 150 - T 09-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 TK78_RS05580 fe11cc3ce61e8ef1cfd4bf3f8b6591e7 400 Gene3D G3DSA:3.40.50.200 128 397 7.8E-85 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS05580 fe11cc3ce61e8ef1cfd4bf3f8b6591e7 400 PRINTS PR00723 Subtilisin serine protease family (S8) signature 190 203 3.8E-20 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS05580 fe11cc3ce61e8ef1cfd4bf3f8b6591e7 400 PRINTS PR00723 Subtilisin serine protease family (S8) signature 343 359 3.8E-20 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS05580 fe11cc3ce61e8ef1cfd4bf3f8b6591e7 400 PRINTS PR00723 Subtilisin serine protease family (S8) signature 152 171 3.8E-20 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS05580 fe11cc3ce61e8ef1cfd4bf3f8b6591e7 400 ProSitePatterns PS00138 Serine proteases, subtilase family, serine active site. 344 354 - T 09-03-2017 IPR023828 Peptidase S8, subtilisin, Ser-active site TK78_RS05580 fe11cc3ce61e8ef1cfd4bf3f8b6591e7 400 ProSitePatterns PS00137 Serine proteases, subtilase family, histidine active site. 194 204 - T 09-03-2017 IPR022398 Peptidase S8, subtilisin, His-active site TK78_RS05580 fe11cc3ce61e8ef1cfd4bf3f8b6591e7 400 SUPERFAMILY SSF52743 128 383 4.45E-75 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS05580 fe11cc3ce61e8ef1cfd4bf3f8b6591e7 400 Pfam PF00082 Subtilase family 152 382 3.0E-40 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS05580 fe11cc3ce61e8ef1cfd4bf3f8b6591e7 400 Pfam PF05922 Peptidase inhibitor I9 66 117 2.0E-6 T 09-03-2017 IPR010259 Peptidase S8 propeptide/proteinase inhibitor I9 TK78_RS05580 fe11cc3ce61e8ef1cfd4bf3f8b6591e7 400 Gene3D G3DSA:3.30.70.80 47 123 3.2E-15 T 09-03-2017 IPR010259 Peptidase S8 propeptide/proteinase inhibitor I9 TK78_RS05580 fe11cc3ce61e8ef1cfd4bf3f8b6591e7 400 SUPERFAMILY SSF54897 54 119 1.19E-6 T 09-03-2017 IPR009020 Proteinase propeptide inhibitor TK78_RS05580 fe11cc3ce61e8ef1cfd4bf3f8b6591e7 400 ProSitePatterns PS00136 Serine proteases, subtilase family, aspartic acid active site. 157 168 - T 09-03-2017 IPR023827 Peptidase S8, subtilisin, Asp-active site TK78_RS03470 10ae71a3d62f494893ae3cdd6951d26a 411 Pfam PF02470 MlaD protein 40 115 1.1E-15 T 09-03-2017 IPR003399 Mce/MlaD TK78_RS03470 10ae71a3d62f494893ae3cdd6951d26a 411 TIGRFAM TIGR00996 Mtu_fam_mce: virulence factor Mce family protein 11 298 4.7E-52 T 09-03-2017 IPR005693 Virulence factor Mce protein TK78_RS07185 7feae2ced5175690823626a4c44202dc 235 SMART SM00345 8 66 6.2E-18 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS07185 7feae2ced5175690823626a4c44202dc 235 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 26 40 1.1E-6 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS07185 7feae2ced5175690823626a4c44202dc 235 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 40 56 1.1E-6 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS07185 7feae2ced5175690823626a4c44202dc 235 SUPERFAMILY SSF46785 7 70 1.63E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS07185 7feae2ced5175690823626a4c44202dc 235 SUPERFAMILY SSF48008 72 200 9.68E-24 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS07185 7feae2ced5175690823626a4c44202dc 235 Pfam PF00392 Bacterial regulatory proteins, gntR family 7 66 8.9E-17 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS07185 7feae2ced5175690823626a4c44202dc 235 Gene3D G3DSA:1.20.120.530 69 202 5.3E-26 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS07185 7feae2ced5175690823626a4c44202dc 235 Pfam PF07729 FCD domain 76 197 9.4E-24 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS07185 7feae2ced5175690823626a4c44202dc 235 Gene3D G3DSA:1.10.10.10 7 68 1.5E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS07185 7feae2ced5175690823626a4c44202dc 235 SMART SM00895 76 198 4.4E-21 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS02795 4cfd352ee6544cc3d37bba282091bdf9 115 Pfam PF13443 Cro/C1-type HTH DNA-binding domain 10 77 1.1E-20 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS02795 4cfd352ee6544cc3d37bba282091bdf9 115 Gene3D G3DSA:1.10.260.40 37 75 9.7E-4 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS12735 f43d63b6b850e4d647ce89117592d824 222 Pfam PF03473 MOSC domain 57 171 3.2E-23 T 09-03-2017 IPR005302 Molybdenum cofactor sulfurase, C-terminal GO:0003824|GO:0030151|GO:0030170 TK78_RS12735 f43d63b6b850e4d647ce89117592d824 222 SUPERFAMILY SSF50800 1 218 6.28E-55 T 09-03-2017 IPR011037 Pyruvate kinase-like, insert domain TK78_RS12735 f43d63b6b850e4d647ce89117592d824 222 Gene3D G3DSA:2.40.33.20 1 220 1.6E-71 T 09-03-2017 IPR015808 Molybdenum cofactor sulfurase, C-terminal-like TK78_RS18755 28f231984c989c4fd3260f785a430af2 195 Gene3D G3DSA:3.40.50.850 11 191 1.2E-35 T 09-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 TK78_RS18755 28f231984c989c4fd3260f785a430af2 195 Pfam PF00857 Isochorismatase family 22 159 6.0E-25 T 09-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 TK78_RS18755 28f231984c989c4fd3260f785a430af2 195 SUPERFAMILY SSF52499 9 192 2.49E-36 T 09-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 TK78_RS26225 a88c0956b5e00739e3cd4f1bdc15a466 295 SUPERFAMILY SSF51621 33 294 1.18E-100 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS26225 a88c0956b5e00739e3cd4f1bdc15a466 295 Pfam PF02548 Ketopantoate hydroxymethyltransferase 33 289 7.0E-107 T 09-03-2017 IPR003700 Ketopantoate hydroxymethyltransferase GO:0003864|GO:0015940 KEGG: 00770+2.1.2.11|MetaCyc: PWY-6654 TK78_RS26225 a88c0956b5e00739e3cd4f1bdc15a466 295 PIRSF PIRSF000388 26 295 3.5E-110 T 09-03-2017 IPR003700 Ketopantoate hydroxymethyltransferase GO:0003864|GO:0015940 KEGG: 00770+2.1.2.11|MetaCyc: PWY-6654 TK78_RS26225 a88c0956b5e00739e3cd4f1bdc15a466 295 TIGRFAM TIGR00222 panB: 3-methyl-2-oxobutanoate hydroxymethyltransferase 41 295 2.2E-93 T 09-03-2017 IPR003700 Ketopantoate hydroxymethyltransferase GO:0003864|GO:0015940 KEGG: 00770+2.1.2.11|MetaCyc: PWY-6654 TK78_RS26225 a88c0956b5e00739e3cd4f1bdc15a466 295 Hamap MF_00156 3-methyl-2-oxobutanoate hydroxymethyltransferase [panB]. 34 294 42.42 T 09-03-2017 IPR003700 Ketopantoate hydroxymethyltransferase GO:0003864|GO:0015940 KEGG: 00770+2.1.2.11|MetaCyc: PWY-6654 TK78_RS26225 a88c0956b5e00739e3cd4f1bdc15a466 295 Gene3D G3DSA:3.20.20.60 32 295 2.7E-111 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS03660 bdcb953858b4b077136ef2e1147a1156 388 PRINTS PR00688 Xylose isomerase signature 107 126 3.0E-70 T 09-03-2017 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 TK78_RS03660 bdcb953858b4b077136ef2e1147a1156 388 PRINTS PR00688 Xylose isomerase signature 47 69 3.0E-70 T 09-03-2017 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 TK78_RS03660 bdcb953858b4b077136ef2e1147a1156 388 PRINTS PR00688 Xylose isomerase signature 180 204 3.0E-70 T 09-03-2017 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 TK78_RS03660 bdcb953858b4b077136ef2e1147a1156 388 PRINTS PR00688 Xylose isomerase signature 250 261 3.0E-70 T 09-03-2017 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 TK78_RS03660 bdcb953858b4b077136ef2e1147a1156 388 PRINTS PR00688 Xylose isomerase signature 84 104 3.0E-70 T 09-03-2017 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 TK78_RS03660 bdcb953858b4b077136ef2e1147a1156 388 PRINTS PR00688 Xylose isomerase signature 282 293 3.0E-70 T 09-03-2017 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 TK78_RS03660 bdcb953858b4b077136ef2e1147a1156 388 PRINTS PR00688 Xylose isomerase signature 222 249 3.0E-70 T 09-03-2017 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 TK78_RS03660 bdcb953858b4b077136ef2e1147a1156 388 PRINTS PR00688 Xylose isomerase signature 158 177 3.0E-70 T 09-03-2017 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 TK78_RS03660 bdcb953858b4b077136ef2e1147a1156 388 PRINTS PR00688 Xylose isomerase signature 131 152 3.0E-70 T 09-03-2017 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 TK78_RS03660 bdcb953858b4b077136ef2e1147a1156 388 Gene3D G3DSA:3.20.20.150 6 387 4.4E-135 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS03660 bdcb953858b4b077136ef2e1147a1156 388 Pfam PF01261 Xylose isomerase-like TIM barrel 43 266 4.3E-24 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS03660 bdcb953858b4b077136ef2e1147a1156 388 TIGRFAM TIGR02631 xylA_Arthro: xylose isomerase 6 385 5.3E-217 T 09-03-2017 IPR013453 Xylose isomerase, actinobacteria GO:0009045|GO:0042732 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 TK78_RS03660 bdcb953858b4b077136ef2e1147a1156 388 Hamap MF_00455 Xylose isomerase [xylA]. 1 384 36.599 T 09-03-2017 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 TK78_RS03660 bdcb953858b4b077136ef2e1147a1156 388 SUPERFAMILY SSF51658 4 386 4.32E-111 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS30255 b93049e5ab489ab45214b2879f326e1d 394 Pfam PF01264 Chorismate synthase 4 368 8.8E-118 T 09-03-2017 IPR000453 Chorismate synthase GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 TK78_RS30255 b93049e5ab489ab45214b2879f326e1d 394 SUPERFAMILY SSF103263 3 391 4.06E-138 T 09-03-2017 IPR000453 Chorismate synthase GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 TK78_RS30255 b93049e5ab489ab45214b2879f326e1d 394 Gene3D G3DSA:3.60.150.10 4 392 8.6E-155 T 09-03-2017 IPR000453 Chorismate synthase GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 TK78_RS30255 b93049e5ab489ab45214b2879f326e1d 394 ProSitePatterns PS00787 Chorismate synthase signature 1. 10 25 - T 09-03-2017 IPR020541 Chorismate synthase, conserved site GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 TK78_RS30255 b93049e5ab489ab45214b2879f326e1d 394 ProSitePatterns PS00789 Chorismate synthase signature 3. 343 359 - T 09-03-2017 IPR020541 Chorismate synthase, conserved site GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 TK78_RS30255 b93049e5ab489ab45214b2879f326e1d 394 Hamap MF_00300 Chorismate synthase [aroC]. 4 376 34.387 T 09-03-2017 IPR000453 Chorismate synthase GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 TK78_RS30255 b93049e5ab489ab45214b2879f326e1d 394 TIGRFAM TIGR00033 aroC: chorismate synthase 4 374 2.1E-140 T 09-03-2017 IPR000453 Chorismate synthase GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 TK78_RS30255 b93049e5ab489ab45214b2879f326e1d 394 PIRSF PIRSF001456 1 387 2.3E-126 T 09-03-2017 IPR000453 Chorismate synthase GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 TK78_RS30255 b93049e5ab489ab45214b2879f326e1d 394 ProSitePatterns PS00788 Chorismate synthase signature 2. 136 152 - T 09-03-2017 IPR020541 Chorismate synthase, conserved site GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 TK78_RS25135 b8687f067ca3194b422f2bf44d23c123 304 Gene3D G3DSA:1.10.3720.10 34 301 1.6E-28 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS25135 b8687f067ca3194b422f2bf44d23c123 304 SUPERFAMILY SSF161098 25 299 2.09E-30 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS25135 b8687f067ca3194b422f2bf44d23c123 304 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 101 290 2.8E-9 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS10395 70159e7cf4d34e1ea29fdd23a2657d2d 271 Pfam PF02586 SOS response associated peptidase (SRAP) 1 251 2.3E-67 T 09-03-2017 IPR003738 SOS response associated peptidase (SRAP) TK78_RS10395 70159e7cf4d34e1ea29fdd23a2657d2d 271 Gene3D G3DSA:3.90.1680.10 1 261 1.8E-75 T 09-03-2017 IPR003738 SOS response associated peptidase (SRAP) TK78_RS10395 70159e7cf4d34e1ea29fdd23a2657d2d 271 SUPERFAMILY SSF143081 2 261 9.94E-66 T 09-03-2017 IPR003738 SOS response associated peptidase (SRAP) TK78_RS11540 34509671162f71995b04be54f620f678 270 Gene3D G3DSA:3.40.50.150 65 269 2.6E-19 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS11540 34509671162f71995b04be54f620f678 270 SUPERFAMILY SSF53335 52 269 4.0E-21 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS11540 34509671162f71995b04be54f620f678 270 Pfam PF08241 Methyltransferase domain 70 156 1.9E-7 T 09-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 TK78_RS06410 7f0735852a92d951a90cc2c8ccf33a75 275 ProSitePatterns PS00166 Enoyl-CoA hydratase/isomerase signature. 115 135 - T 09-03-2017 IPR018376 Enoyl-CoA hydratase/isomerase, conserved site GO:0003824|GO:0008152 TK78_RS06410 7f0735852a92d951a90cc2c8ccf33a75 275 SUPERFAMILY SSF52096 12 275 1.48E-77 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS06410 7f0735852a92d951a90cc2c8ccf33a75 275 Pfam PF00378 Enoyl-CoA hydratase/isomerase 22 274 4.3E-51 T 09-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 TK78_RS06410 7f0735852a92d951a90cc2c8ccf33a75 275 Gene3D G3DSA:3.90.226.10 10 215 6.1E-58 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS06410 7f0735852a92d951a90cc2c8ccf33a75 275 Gene3D G3DSA:1.10.12.10 217 275 3.6E-23 T 09-03-2017 IPR014748 Crontonase, C-terminal TK78_RS31490 970133ccf81f4043b63da539bb104b2e 385 Gene3D G3DSA:3.30.420.40 84 225 2.5E-38 T 09-03-2017 TK78_RS31490 970133ccf81f4043b63da539bb104b2e 385 SUPERFAMILY SSF53067 86 372 1.92E-42 T 09-03-2017 TK78_RS31490 970133ccf81f4043b63da539bb104b2e 385 Gene3D G3DSA:3.30.420.40 226 350 1.9E-21 T 09-03-2017 TK78_RS31490 970133ccf81f4043b63da539bb104b2e 385 SUPERFAMILY SSF46785 11 72 4.85E-10 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS31490 970133ccf81f4043b63da539bb104b2e 385 Pfam PF09339 IclR helix-turn-helix domain 20 60 5.3E-5 T 09-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 TK78_RS31490 970133ccf81f4043b63da539bb104b2e 385 Gene3D G3DSA:1.10.10.10 11 81 1.4E-13 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS31490 970133ccf81f4043b63da539bb104b2e 385 Pfam PF00480 ROK family 274 367 5.4E-8 T 09-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 TK78_RS31490 970133ccf81f4043b63da539bb104b2e 385 Pfam PF00480 ROK family 89 249 1.7E-23 T 09-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 TK78_RS22245 a9d6f5d3614039b8dadf86d13454dcc4 368 Pfam PF03462 PCRF domain 30 219 1.3E-55 T 09-03-2017 IPR005139 Peptide chain release factor GO:0005737|GO:0006415|GO:0016149 TK78_RS22245 a9d6f5d3614039b8dadf86d13454dcc4 368 ProSitePatterns PS00745 Prokaryotic-type class I peptide chain release factors signature. 244 260 - T 09-03-2017 IPR000352 Peptide chain release factor class I/class II GO:0003747|GO:0006415 TK78_RS22245 a9d6f5d3614039b8dadf86d13454dcc4 368 SMART SM00937 84 194 3.4E-41 T 09-03-2017 IPR005139 Peptide chain release factor GO:0005737|GO:0006415|GO:0016149 TK78_RS22245 a9d6f5d3614039b8dadf86d13454dcc4 368 TIGRFAM TIGR00020 prfB: peptide chain release factor 2 3 363 7.3E-153 T 09-03-2017 IPR004374 Peptide chain release factor 2 GO:0005737|GO:0006415|GO:0016149 TK78_RS22245 a9d6f5d3614039b8dadf86d13454dcc4 368 Gene3D G3DSA:1.20.58.410 4 115 8.1E-34 T 09-03-2017 TK78_RS22245 a9d6f5d3614039b8dadf86d13454dcc4 368 Pfam PF00472 RF-1 domain 228 336 5.8E-38 T 09-03-2017 IPR000352 Peptide chain release factor class I/class II GO:0003747|GO:0006415 TK78_RS22245 a9d6f5d3614039b8dadf86d13454dcc4 368 Gene3D G3DSA:3.30.160.20 227 305 2.0E-35 T 09-03-2017 IPR014720 Double-stranded RNA-binding domain TK78_RS22245 a9d6f5d3614039b8dadf86d13454dcc4 368 Hamap MF_00094 Peptide chain release factor 2 [prfB]. 2 364 37.647 T 09-03-2017 IPR020853 Peptide chain release factor 2, bacterial GO:0005737|GO:0006415|GO:0016149 TK78_RS22245 a9d6f5d3614039b8dadf86d13454dcc4 368 SUPERFAMILY SSF75620 29 365 6.28E-120 T 09-03-2017 TK78_RS09825 46d3fb81cf4434ae90e53ee95dbe0bf2 758 SUPERFAMILY SSF48452 480 699 2.24E-18 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS09825 46d3fb81cf4434ae90e53ee95dbe0bf2 758 Pfam PF00931 NB-ARC domain 74 310 1.2E-8 T 09-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 TK78_RS09825 46d3fb81cf4434ae90e53ee95dbe0bf2 758 Gene3D G3DSA:1.25.40.10 517 696 6.8E-17 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS09825 46d3fb81cf4434ae90e53ee95dbe0bf2 758 Pfam PF13424 Tetratricopeptide repeat 516 576 2.2E-7 T 09-03-2017 TK78_RS09825 46d3fb81cf4434ae90e53ee95dbe0bf2 758 Gene3D G3DSA:3.40.50.300 72 170 2.8E-4 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09825 46d3fb81cf4434ae90e53ee95dbe0bf2 758 SUPERFAMILY SSF52540 74 307 4.6E-20 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09825 46d3fb81cf4434ae90e53ee95dbe0bf2 758 PRINTS PR00364 Disease resistance protein signature 77 92 8.3E-10 T 09-03-2017 TK78_RS09825 46d3fb81cf4434ae90e53ee95dbe0bf2 758 PRINTS PR00364 Disease resistance protein signature 155 169 8.3E-10 T 09-03-2017 TK78_RS09825 46d3fb81cf4434ae90e53ee95dbe0bf2 758 PRINTS PR00364 Disease resistance protein signature 241 255 8.3E-10 T 09-03-2017 TK78_RS09825 46d3fb81cf4434ae90e53ee95dbe0bf2 758 SMART SM00028 546 579 1.3 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS09825 46d3fb81cf4434ae90e53ee95dbe0bf2 758 SMART SM00028 586 619 140.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS09825 46d3fb81cf4434ae90e53ee95dbe0bf2 758 SMART SM00028 666 699 0.65 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS15820 f5e7012e3f0b64e74be67758fa3bef20 615 Gene3D G3DSA:3.60.15.10 220 336 2.9E-39 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS15820 f5e7012e3f0b64e74be67758fa3bef20 615 Gene3D G3DSA:3.60.15.10 63 183 2.9E-39 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS15820 f5e7012e3f0b64e74be67758fa3bef20 615 Pfam PF00753 Metallo-beta-lactamase superfamily 93 315 1.1E-26 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS15820 f5e7012e3f0b64e74be67758fa3bef20 615 Pfam PF14863 Alkyl sulfatase dimerisation 352 490 2.9E-56 T 09-03-2017 IPR029228 Alkyl sulfatase dimerisation domain GO:0046983 TK78_RS15820 f5e7012e3f0b64e74be67758fa3bef20 615 SMART SM00849 97 315 3.5E-19 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS15820 f5e7012e3f0b64e74be67758fa3bef20 615 Pfam PF14864 Alkyl sulfatase C-terminal 499 615 2.4E-34 T 09-03-2017 IPR029229 Alkyl sulfatase, C-terminal TK78_RS15820 f5e7012e3f0b64e74be67758fa3bef20 615 SUPERFAMILY SSF56281 15 494 5.42E-141 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS15820 f5e7012e3f0b64e74be67758fa3bef20 615 SUPERFAMILY SSF55718 499 615 3.83E-24 T 09-03-2017 IPR003033 SCP2 sterol-binding domain TK78_RS27685 95494af1c793324845b263a690b8a761 201 Hamap MF_00376 Dephospho-CoA kinase [coaE]. 1 196 26.748 T 09-03-2017 IPR001977 Dephospho-CoA kinase GO:0004140|GO:0005524|GO:0015937 KEGG: 00770+2.7.1.24 TK78_RS27685 95494af1c793324845b263a690b8a761 201 Gene3D G3DSA:3.40.50.300 1 197 2.2E-69 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27685 95494af1c793324845b263a690b8a761 201 TIGRFAM TIGR00152 TIGR00152: dephospho-CoA kinase 4 186 9.2E-48 T 09-03-2017 IPR001977 Dephospho-CoA kinase GO:0004140|GO:0005524|GO:0015937 KEGG: 00770+2.7.1.24 TK78_RS27685 95494af1c793324845b263a690b8a761 201 Pfam PF01121 Dephospho-CoA kinase 4 177 1.3E-57 T 09-03-2017 IPR001977 Dephospho-CoA kinase GO:0004140|GO:0005524|GO:0015937 KEGG: 00770+2.7.1.24 TK78_RS27685 95494af1c793324845b263a690b8a761 201 SUPERFAMILY SSF52540 1 192 1.24E-37 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24730 c859d7a7db1793d8768cd234441ede23 477 ProSitePatterns PS00122 Carboxylesterases type-B serine active site. 171 186 - T 09-03-2017 IPR019826 Carboxylesterase type B, active site TK78_RS24730 c859d7a7db1793d8768cd234441ede23 477 Gene3D G3DSA:3.40.50.1820 3 476 1.3E-127 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS24730 c859d7a7db1793d8768cd234441ede23 477 Pfam PF00135 Carboxylesterase family 3 307 2.8E-87 T 09-03-2017 IPR002018 Carboxylesterase, type B TK78_RS24730 c859d7a7db1793d8768cd234441ede23 477 Pfam PF00135 Carboxylesterase family 353 450 6.7E-8 T 09-03-2017 IPR002018 Carboxylesterase, type B TK78_RS24730 c859d7a7db1793d8768cd234441ede23 477 SUPERFAMILY SSF53474 3 476 2.87E-111 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS11265 6788b0a1a88a9245e9a96a7032e6bcfc 250 Pfam PF07702 UTRA domain 110 242 6.2E-13 T 09-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 TK78_RS11265 6788b0a1a88a9245e9a96a7032e6bcfc 250 Gene3D G3DSA:1.10.10.10 8 73 1.5E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS11265 6788b0a1a88a9245e9a96a7032e6bcfc 250 SUPERFAMILY SSF46785 4 83 8.47E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS11265 6788b0a1a88a9245e9a96a7032e6bcfc 250 SMART SM00345 12 71 1.4E-11 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS11265 6788b0a1a88a9245e9a96a7032e6bcfc 250 SUPERFAMILY SSF64288 59 248 5.18E-24 T 09-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain TK78_RS11265 6788b0a1a88a9245e9a96a7032e6bcfc 250 Pfam PF00392 Bacterial regulatory proteins, gntR family 9 71 7.1E-15 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS11265 6788b0a1a88a9245e9a96a7032e6bcfc 250 SMART SM00866 100 242 2.3E-10 T 09-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 TK78_RS11265 6788b0a1a88a9245e9a96a7032e6bcfc 250 Gene3D G3DSA:3.40.1410.10 74 245 6.9E-56 T 09-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain TK78_RS24670 bb321566b1285a4fb5b0882c80177451 293 SMART SM00867 122 290 6.7E-51 T 09-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like TK78_RS24670 bb321566b1285a4fb5b0882c80177451 293 Gene3D G3DSA:2.40.128.110 122 291 3.5E-49 T 09-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like TK78_RS24670 bb321566b1285a4fb5b0882c80177451 293 Pfam PF13620 Carboxypeptidase regulatory-like domain 32 110 5.1E-8 T 09-03-2017 TK78_RS24670 bb321566b1285a4fb5b0882c80177451 293 SUPERFAMILY SSF49464 34 114 1.84E-6 T 09-03-2017 IPR008969 Carboxypeptidase-like, regulatory domain TK78_RS24670 bb321566b1285a4fb5b0882c80177451 293 SUPERFAMILY SSF101874 121 291 1.57E-45 T 09-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like TK78_RS24670 bb321566b1285a4fb5b0882c80177451 293 Pfam PF04264 YceI-like domain 123 288 1.2E-35 T 09-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like TK78_RS24670 bb321566b1285a4fb5b0882c80177451 293 Gene3D G3DSA:2.60.40.1120 32 112 1.2E-7 T 09-03-2017 IPR014766 Carboxypeptidase, regulatory domain TK78_RS11010 6e4124f52ce89ddb1e2151edad26110f 356 Gene3D G3DSA:3.40.50.2300 191 333 1.6E-48 T 09-03-2017 TK78_RS11010 6e4124f52ce89ddb1e2151edad26110f 356 Gene3D G3DSA:1.10.260.40 4 59 9.5E-23 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS11010 6e4124f52ce89ddb1e2151edad26110f 356 Pfam PF00356 Bacterial regulatory proteins, lacI family 5 50 2.4E-18 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS11010 6e4124f52ce89ddb1e2151edad26110f 356 SUPERFAMILY SSF53822 94 354 6.48E-52 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS11010 6e4124f52ce89ddb1e2151edad26110f 356 SUPERFAMILY SSF47413 3 61 6.88E-17 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS11010 6e4124f52ce89ddb1e2151edad26110f 356 Gene3D G3DSA:3.40.50.2300 60 190 3.0E-32 T 09-03-2017 TK78_RS11010 6e4124f52ce89ddb1e2151edad26110f 356 Pfam PF13377 Periplasmic binding protein-like domain 186 353 2.6E-42 T 09-03-2017 TK78_RS11010 6e4124f52ce89ddb1e2151edad26110f 356 SMART SM00354 3 73 1.2E-26 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS17755 ab7d03293493369ddb6bc972d480db89 435 SUPERFAMILY SSF103473 13 422 1.23E-59 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS17755 ab7d03293493369ddb6bc972d480db89 435 Gene3D G3DSA:1.20.1250.20 26 210 3.4E-29 T 09-03-2017 TK78_RS17755 ab7d03293493369ddb6bc972d480db89 435 Pfam PF07690 Major Facilitator Superfamily 30 263 7.8E-24 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS17755 ab7d03293493369ddb6bc972d480db89 435 Gene3D G3DSA:1.20.1250.20 242 421 1.7E-16 T 09-03-2017 TK78_RS17215 c427dad297349212ef84d91c3b51f0cd 148 TIGRFAM TIGR00158 L9: ribosomal protein bL9 1 147 5.3E-40 T 09-03-2017 IPR020594 Ribosomal protein L9, bacteria/chloroplast GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS17215 c427dad297349212ef84d91c3b51f0cd 148 Gene3D G3DSA:3.40.5.10 1 51 7.8E-22 T 09-03-2017 IPR020070 Ribosomal protein L9, N-terminal Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS17215 c427dad297349212ef84d91c3b51f0cd 148 SUPERFAMILY SSF55658 1 56 3.49E-17 T 09-03-2017 IPR009027 Ribosomal protein L9/RNase H1, N-terminal TK78_RS17215 c427dad297349212ef84d91c3b51f0cd 148 SUPERFAMILY SSF55653 59 147 7.98E-25 T 09-03-2017 IPR020069 Ribosomal protein L9, C-terminal TK78_RS17215 c427dad297349212ef84d91c3b51f0cd 148 ProSitePatterns PS00651 Ribosomal protein L9 signature. 13 40 - T 09-03-2017 IPR020070 Ribosomal protein L9, N-terminal Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS17215 c427dad297349212ef84d91c3b51f0cd 148 Hamap MF_00503 50S ribosomal protein L9 [rplI]. 1 148 25.481 T 09-03-2017 IPR020594 Ribosomal protein L9, bacteria/chloroplast GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS17215 c427dad297349212ef84d91c3b51f0cd 148 Gene3D G3DSA:3.10.430.100 62 147 3.4E-30 T 09-03-2017 IPR020069 Ribosomal protein L9, C-terminal TK78_RS17215 c427dad297349212ef84d91c3b51f0cd 148 Pfam PF01281 Ribosomal protein L9, N-terminal domain 1 45 4.7E-21 T 09-03-2017 IPR020070 Ribosomal protein L9, N-terminal Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS17215 c427dad297349212ef84d91c3b51f0cd 148 Pfam PF03948 Ribosomal protein L9, C-terminal domain 63 147 1.5E-28 T 09-03-2017 IPR020069 Ribosomal protein L9, C-terminal TK78_RS05305 9d0b326a654491afdc1ff2af02cdddd9 121 Pfam PF13581 Histidine kinase-like ATPase domain 5 114 5.1E-13 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS05305 9d0b326a654491afdc1ff2af02cdddd9 121 Gene3D G3DSA:3.30.565.10 34 106 6.4E-4 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS05305 9d0b326a654491afdc1ff2af02cdddd9 121 SUPERFAMILY SSF55874 28 117 8.88E-8 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS28940 7f7ba2b8d2301c8fc9c18112ade1cc92 124 SUPERFAMILY SSF46785 7 82 4.69E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS28940 7f7ba2b8d2301c8fc9c18112ade1cc92 124 SMART SM00345 19 78 7.9E-12 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS28940 7f7ba2b8d2301c8fc9c18112ade1cc92 124 Gene3D G3DSA:1.10.10.10 6 79 1.5E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS28940 7f7ba2b8d2301c8fc9c18112ade1cc92 124 Pfam PF00392 Bacterial regulatory proteins, gntR family 15 78 1.9E-14 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS07230 b91b2bf70d0a7528aa5a02a947bc82bd 560 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 425 535 4.4E-20 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS07230 b91b2bf70d0a7528aa5a02a947bc82bd 560 SMART SM00387 424 536 2.8E-27 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS07230 b91b2bf70d0a7528aa5a02a947bc82bd 560 Pfam PF17203 Single cache domain 3 49 182 8.0E-26 T 09-03-2017 IPR033463 Single cache domain 3 TK78_RS07230 b91b2bf70d0a7528aa5a02a947bc82bd 560 Gene3D G3DSA:1.10.287.130 316 377 2.8E-16 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS07230 b91b2bf70d0a7528aa5a02a947bc82bd 560 SUPERFAMILY SSF103190 49 180 1.37E-31 T 09-03-2017 IPR029151 Periplasmic sensor domain-like TK78_RS07230 b91b2bf70d0a7528aa5a02a947bc82bd 560 PRINTS PR00344 Bacterial sensor protein C-terminal signature 520 533 8.6E-12 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS07230 b91b2bf70d0a7528aa5a02a947bc82bd 560 PRINTS PR00344 Bacterial sensor protein C-terminal signature 463 477 8.6E-12 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS07230 b91b2bf70d0a7528aa5a02a947bc82bd 560 PRINTS PR00344 Bacterial sensor protein C-terminal signature 496 514 8.6E-12 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS07230 b91b2bf70d0a7528aa5a02a947bc82bd 560 Pfam PF14689 Sensor_kinase_SpoOB-type, alpha-helical domain 329 374 3.6E-8 T 09-03-2017 TK78_RS07230 b91b2bf70d0a7528aa5a02a947bc82bd 560 Gene3D G3DSA:3.30.565.10 393 539 3.7E-30 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS07230 b91b2bf70d0a7528aa5a02a947bc82bd 560 Pfam PF00989 PAS fold 227 265 2.2E-6 T 09-03-2017 IPR013767 PAS fold GO:0006355 TK78_RS07230 b91b2bf70d0a7528aa5a02a947bc82bd 560 Gene3D G3DSA:3.30.450.20 217 274 1.2E-7 T 09-03-2017 TK78_RS07230 b91b2bf70d0a7528aa5a02a947bc82bd 560 SUPERFAMILY SSF55874 400 538 1.17E-29 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS07230 b91b2bf70d0a7528aa5a02a947bc82bd 560 Gene3D G3DSA:3.30.450.20 45 181 9.1E-45 T 09-03-2017 TK78_RS07230 b91b2bf70d0a7528aa5a02a947bc82bd 560 SUPERFAMILY SSF55890 329 398 1.31E-8 T 09-03-2017 IPR016120 Signal transduction histidine kinase, sporulation regulator SpoOB GO:0000155|GO:0000160|GO:0016772 TK78_RS07230 b91b2bf70d0a7528aa5a02a947bc82bd 560 SUPERFAMILY SSF55785 229 288 5.23E-6 T 09-03-2017 IPR000014 PAS domain TK78_RS00960 511c9d4a001bd682e85ac7c52e861cfd 137 SUPERFAMILY SSF103196 6 127 2.27E-33 T 09-03-2017 TK78_RS00960 511c9d4a001bd682e85ac7c52e861cfd 137 Gene3D G3DSA:3.30.450.30 7 122 5.9E-26 T 09-03-2017 TK78_RS00960 511c9d4a001bd682e85ac7c52e861cfd 137 Pfam PF03259 Roadblock/LC7 domain 7 98 1.5E-24 T 09-03-2017 IPR004942 Roadblock/LAMTOR2 domain TK78_RS00960 511c9d4a001bd682e85ac7c52e861cfd 137 SMART SM00960 8 98 3.0E-29 T 09-03-2017 IPR004942 Roadblock/LAMTOR2 domain TK78_RS00150 87bb4ff24fb7464553753c541a0a1363 147 SUPERFAMILY SSF55961 8 145 1.53E-26 T 09-03-2017 TK78_RS00150 87bb4ff24fb7464553753c541a0a1363 147 Gene3D G3DSA:3.30.530.20 7 145 7.6E-24 T 09-03-2017 IPR023393 START-like domain TK78_RS00150 87bb4ff24fb7464553753c541a0a1363 147 Pfam PF08327 Activator of Hsp90 ATPase homolog 1-like protein 18 143 1.9E-19 T 09-03-2017 IPR013538 Activator of Hsp90 ATPase homologue 1-like GO:0006950 TK78_RS06450 f68bbc95dedbaef45bb22a683694203a 307 Pfam PF00296 Luciferase-like monooxygenase 8 248 1.4E-52 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS06450 f68bbc95dedbaef45bb22a683694203a 307 SUPERFAMILY SSF51679 4 303 2.62E-65 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS06450 f68bbc95dedbaef45bb22a683694203a 307 Gene3D G3DSA:3.20.20.30 8 303 2.3E-73 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS06450 f68bbc95dedbaef45bb22a683694203a 307 TIGRFAM TIGR03560 F420_Rv1855c: probable F420-dependent oxidoreductase, Rv1855c family 2 228 3.4E-90 T 09-03-2017 IPR019952 F420-dependent oxidoreductase-predicted, Rv1855c TK78_RS30210 00aeef6f3d49bfa38f9f76e144411801 233 Pfam PF10615 Protein of unknown function (DUF2470) 145 224 7.5E-5 T 09-03-2017 IPR019595 Domain of unknown function DUF2470 TK78_RS30210 00aeef6f3d49bfa38f9f76e144411801 233 SUPERFAMILY SSF50475 98 231 2.67E-11 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS30210 00aeef6f3d49bfa38f9f76e144411801 233 Gene3D G3DSA:3.20.180.10 138 231 2.3E-6 T 09-03-2017 IPR019595 Domain of unknown function DUF2470 TK78_RS13530 adf9242daf5fa4fbb3afb4e70231f477 196 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 39 62 7.6E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS13530 adf9242daf5fa4fbb3afb4e70231f477 196 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 18 31 7.6E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS13530 adf9242daf5fa4fbb3afb4e70231f477 196 SUPERFAMILY SSF48498 77 194 2.6E-22 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS13530 adf9242daf5fa4fbb3afb4e70231f477 196 Gene3D G3DSA:1.10.10.60 9 56 1.0E-20 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS13530 adf9242daf5fa4fbb3afb4e70231f477 196 Gene3D G3DSA:1.10.357.10 57 194 1.3E-37 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS13530 adf9242daf5fa4fbb3afb4e70231f477 196 Pfam PF00440 Bacterial regulatory proteins, tetR family 18 64 1.1E-12 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS13530 adf9242daf5fa4fbb3afb4e70231f477 196 Pfam PF16859 Bacterial transcriptional repressor C-terminal 76 187 2.0E-26 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS13530 adf9242daf5fa4fbb3afb4e70231f477 196 SUPERFAMILY SSF46689 9 69 9.71E-16 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS08630 6be2df6b947bed479a8190cb12fbf7be 1033 SUPERFAMILY SSF52279 744 946 4.58E-50 T 09-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 TK78_RS08630 6be2df6b947bed479a8190cb12fbf7be 1033 Pfam PF03425 Carbohydrate binding domain (family 11) 49 233 3.7E-43 T 09-03-2017 IPR005087 Carbohydrate binding module family 11 GO:0008810|GO:0030245 TK78_RS08630 6be2df6b947bed479a8190cb12fbf7be 1033 Pfam PF01915 Glycosyl hydrolase family 3 C-terminal domain 744 945 5.4E-35 T 09-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 TK78_RS08630 6be2df6b947bed479a8190cb12fbf7be 1033 PRINTS PR00133 Glycosyl hydrolase family 3 signature 434 450 1.7E-20 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS08630 6be2df6b947bed479a8190cb12fbf7be 1033 PRINTS PR00133 Glycosyl hydrolase family 3 signature 629 647 1.7E-20 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS08630 6be2df6b947bed479a8190cb12fbf7be 1033 PRINTS PR00133 Glycosyl hydrolase family 3 signature 544 560 1.7E-20 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS08630 6be2df6b947bed479a8190cb12fbf7be 1033 PRINTS PR00133 Glycosyl hydrolase family 3 signature 458 477 1.7E-20 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS08630 6be2df6b947bed479a8190cb12fbf7be 1033 PRINTS PR00133 Glycosyl hydrolase family 3 signature 504 520 1.7E-20 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS08630 6be2df6b947bed479a8190cb12fbf7be 1033 Gene3D G3DSA:3.40.50.1700 728 946 2.0E-62 T 09-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 TK78_RS08630 6be2df6b947bed479a8190cb12fbf7be 1033 Pfam PF03160 Calx-beta domain 257 313 2.5E-6 T 09-03-2017 IPR003644 Na-Ca exchanger/integrin-beta4 GO:0007154|GO:0016021 TK78_RS08630 6be2df6b947bed479a8190cb12fbf7be 1033 ProSitePatterns PS00775 Glycosyl hydrolases family 3 active site. 629 646 - T 09-03-2017 IPR019800 Glycoside hydrolase, family 3, active site GO:0004553|GO:0005975 TK78_RS08630 6be2df6b947bed479a8190cb12fbf7be 1033 Pfam PF00933 Glycosyl hydrolase family 3 N terminal domain 374 705 2.1E-68 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS08630 6be2df6b947bed479a8190cb12fbf7be 1033 SUPERFAMILY SSF49785 48 230 2.55E-21 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS08630 6be2df6b947bed479a8190cb12fbf7be 1033 Gene3D G3DSA:3.20.20.300 353 725 3.7E-108 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS08630 6be2df6b947bed479a8190cb12fbf7be 1033 SUPERFAMILY SSF51445 352 742 4.53E-103 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS08630 6be2df6b947bed479a8190cb12fbf7be 1033 SUPERFAMILY SSF141072 259 334 6.8E-10 T 09-03-2017 TK78_RS13745 81614b0e985ac0cb6621fa691897980a 399 Gene3D G3DSA:3.20.20.70 18 352 4.0E-61 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS13745 81614b0e985ac0cb6621fa691897980a 399 PIRSF PIRSF004762 1 373 1.9E-106 T 09-03-2017 IPR005244 FO synthase, subunit 2-like GO:0016765|GO:0051188|GO:0051539 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198 TK78_RS13745 81614b0e985ac0cb6621fa691897980a 399 Pfam PF04055 Radical SAM superfamily 65 238 5.9E-14 T 09-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 TK78_RS13745 81614b0e985ac0cb6621fa691897980a 399 TIGRFAM TIGR00423 TIGR00423: radical SAM domain protein, CofH subfamily 57 360 4.1E-101 T 09-03-2017 IPR020050 FO synthase, subunit 2 GO:0016765 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198 TK78_RS13745 81614b0e985ac0cb6621fa691897980a 399 Hamap MF_00992 Cyclic dehypoxanthine futalosine synthase [mqnC]. 17 363 50.369 T 09-03-2017 IPR022431 Cyclic dehypoxanthine futalosine synthase GO:0009234 KEGG: 00130+1.21.98.1|MetaCyc: PWY-7371|MetaCyc: PWY-7374 TK78_RS13745 81614b0e985ac0cb6621fa691897980a 399 TIGRFAM TIGR03699 menaquin_MqnC: dehypoxanthine futalosine cyclase 19 360 5.7E-138 T 09-03-2017 IPR022431 Cyclic dehypoxanthine futalosine synthase GO:0009234 KEGG: 00130+1.21.98.1|MetaCyc: PWY-7371|MetaCyc: PWY-7374 TK78_RS13745 81614b0e985ac0cb6621fa691897980a 399 SUPERFAMILY SSF102114 17 316 1.57E-48 T 09-03-2017 TK78_RS29840 7791735f59a7134a694ebbbdf4a78eec 475 ProSitePatterns PS00163 Fumarate lyases signature. 284 293 - T 09-03-2017 IPR020557 Fumarate lyase, conserved site GO:0003824 TK78_RS29840 7791735f59a7134a694ebbbdf4a78eec 475 Gene3D G3DSA:1.10.40.30 383 439 1.7E-28 T 09-03-2017 TK78_RS29840 7791735f59a7134a694ebbbdf4a78eec 475 Pfam PF00206 Lyase 24 309 7.3E-65 T 09-03-2017 IPR022761 Fumarate lyase, N-terminal TK78_RS29840 7791735f59a7134a694ebbbdf4a78eec 475 Gene3D G3DSA:1.20.200.10 115 382 1.3E-98 T 09-03-2017 TK78_RS29840 7791735f59a7134a694ebbbdf4a78eec 475 SUPERFAMILY SSF48557 14 464 5.18E-137 T 09-03-2017 IPR008948 L-Aspartase-like GO:0003824 TK78_RS29840 7791735f59a7134a694ebbbdf4a78eec 475 Gene3D G3DSA:1.10.275.10 9 114 1.4E-34 T 09-03-2017 IPR024083 Fumarase/histidase, N-terminal TK78_RS29840 7791735f59a7134a694ebbbdf4a78eec 475 Hamap MF_00006 Argininosuccinate lyase [argH]. 9 462 40.832 T 09-03-2017 IPR009049 Argininosuccinate lyase GO:0004056|GO:0042450 KEGG: 00220+4.3.2.1|KEGG: 00250+4.3.2.1|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 TK78_RS29840 7791735f59a7134a694ebbbdf4a78eec 475 TIGRFAM TIGR00838 argH: argininosuccinate lyase 10 464 2.7E-183 T 09-03-2017 IPR009049 Argininosuccinate lyase GO:0004056|GO:0042450 KEGG: 00220+4.3.2.1|KEGG: 00250+4.3.2.1|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 TK78_RS29840 7791735f59a7134a694ebbbdf4a78eec 475 PRINTS PR00149 Fumarate lyase superfamily signature 110 128 2.0E-26 T 09-03-2017 IPR000362 Fumarate lyase family TK78_RS29840 7791735f59a7134a694ebbbdf4a78eec 475 PRINTS PR00149 Fumarate lyase superfamily signature 240 267 2.0E-26 T 09-03-2017 IPR000362 Fumarate lyase family TK78_RS29840 7791735f59a7134a694ebbbdf4a78eec 475 PRINTS PR00149 Fumarate lyase superfamily signature 284 300 2.0E-26 T 09-03-2017 IPR000362 Fumarate lyase family TK78_RS29840 7791735f59a7134a694ebbbdf4a78eec 475 PRINTS PR00149 Fumarate lyase superfamily signature 155 173 2.0E-26 T 09-03-2017 IPR000362 Fumarate lyase family TK78_RS29840 7791735f59a7134a694ebbbdf4a78eec 475 PRINTS PR00145 Argininosuccinate lyase family signature 319 338 1.1E-54 T 09-03-2017 TK78_RS29840 7791735f59a7134a694ebbbdf4a78eec 475 PRINTS PR00145 Argininosuccinate lyase family signature 240 264 1.1E-54 T 09-03-2017 TK78_RS29840 7791735f59a7134a694ebbbdf4a78eec 475 PRINTS PR00145 Argininosuccinate lyase family signature 150 170 1.1E-54 T 09-03-2017 TK78_RS29840 7791735f59a7134a694ebbbdf4a78eec 475 PRINTS PR00145 Argininosuccinate lyase family signature 284 300 1.1E-54 T 09-03-2017 TK78_RS29840 7791735f59a7134a694ebbbdf4a78eec 475 PRINTS PR00145 Argininosuccinate lyase family signature 201 217 1.1E-54 T 09-03-2017 TK78_RS29840 7791735f59a7134a694ebbbdf4a78eec 475 PRINTS PR00145 Argininosuccinate lyase family signature 109 131 1.1E-54 T 09-03-2017 TK78_RS29840 7791735f59a7134a694ebbbdf4a78eec 475 Pfam PF14698 Argininosuccinate lyase C-terminal 372 439 4.2E-22 T 09-03-2017 IPR029419 Argininosuccinate lyase, C-terminal KEGG: 00220+4.3.2.1|KEGG: 00250+4.3.2.1|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 TK78_RS06880 804be570e71eddf565438e156f03bb7b 847 Gene3D G3DSA:3.30.565.10 668 830 5.1E-38 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS06880 804be570e71eddf565438e156f03bb7b 847 Gene3D G3DSA:3.40.50.300 2 210 1.4E-98 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06880 804be570e71eddf565438e156f03bb7b 847 Gene3D G3DSA:3.40.50.620 227 346 9.8E-10 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS06880 804be570e71eddf565438e156f03bb7b 847 SUPERFAMILY SSF52402 231 347 6.58E-8 T 09-03-2017 TK78_RS06880 804be570e71eddf565438e156f03bb7b 847 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 723 829 1.3E-18 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS06880 804be570e71eddf565438e156f03bb7b 847 SMART SM00387 722 832 1.7E-28 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS06880 804be570e71eddf565438e156f03bb7b 847 Gene3D G3DSA:1.20.120.620 380 480 2.5E-19 T 09-03-2017 TK78_RS06880 804be570e71eddf565438e156f03bb7b 847 SMART SM00388 614 682 5.7E-18 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS06880 804be570e71eddf565438e156f03bb7b 847 Pfam PF00512 His Kinase A (phospho-acceptor) domain 615 682 2.2E-17 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS06880 804be570e71eddf565438e156f03bb7b 847 Gene3D G3DSA:1.10.287.130 605 667 2.0E-19 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS06880 804be570e71eddf565438e156f03bb7b 847 Pfam PF13493 Domain of unknown function (DUF4118) 383 488 5.9E-26 T 09-03-2017 IPR025201 Sensor protein KdpD, transmembrane domain TK78_RS06880 804be570e71eddf565438e156f03bb7b 847 SUPERFAMILY SSF47384 603 682 2.94E-17 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS06880 804be570e71eddf565438e156f03bb7b 847 Pfam PF00582 Universal stress protein family 232 344 1.5E-4 T 09-03-2017 IPR006016 UspA GO:0006950 TK78_RS06880 804be570e71eddf565438e156f03bb7b 847 SUPERFAMILY SSF55874 672 829 1.44E-35 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS06880 804be570e71eddf565438e156f03bb7b 847 Pfam PF02702 Osmosensitive K+ channel His kinase sensor domain 3 211 1.4E-99 T 09-03-2017 IPR003852 Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal GO:0000155|GO:0000160|GO:0004673|GO:0016020 TK78_RS06880 804be570e71eddf565438e156f03bb7b 847 PRINTS PR00344 Bacterial sensor protein C-terminal signature 816 829 6.2E-11 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS06880 804be570e71eddf565438e156f03bb7b 847 PRINTS PR00344 Bacterial sensor protein C-terminal signature 759 773 6.2E-11 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS06880 804be570e71eddf565438e156f03bb7b 847 PRINTS PR00344 Bacterial sensor protein C-terminal signature 792 810 6.2E-11 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS06880 804be570e71eddf565438e156f03bb7b 847 PRINTS PR00344 Bacterial sensor protein C-terminal signature 777 787 6.2E-11 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 SUPERFAMILY SSF56801 1550 2121 3.66E-160 T 09-03-2017 TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 Pfam PF13193 AMP-binding enzyme C-terminal domain 2008 2083 2.2E-15 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 Pfam PF13193 AMP-binding enzyme C-terminal domain 922 998 1.1E-12 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 Gene3D G3DSA:3.30.300.30 1995 2111 1.2E-42 T 09-03-2017 TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 Gene3D G3DSA:3.40.50.1820 2179 2304 8.6E-46 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 Gene3D G3DSA:3.40.50.1820 2377 2445 8.6E-46 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 SUPERFAMILY SSF56801 499 1007 2.09E-121 T 09-03-2017 TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 SUPERFAMILY SSF56801 416 471 2.09E-121 T 09-03-2017 TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 ProSitePatterns PS00455 Putative AMP-binding domain signature. 650 661 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 SUPERFAMILY SSF52777 176 413 4.89E-38 T 09-03-2017 TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 SUPERFAMILY SSF47336 2101 2173 2.49E-20 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 Gene3D G3DSA:1.10.1200.10 2112 2178 3.3E-27 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 Gene3D G3DSA:1.10.1200.10 1018 1097 1.7E-17 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 Pfam PF00501 AMP-binding enzyme 1593 2000 9.7E-97 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 Pfam PF00501 AMP-binding enzyme 549 914 4.7E-69 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 Gene3D G3DSA:2.30.38.10 823 904 1.4E-24 T 09-03-2017 TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 Gene3D G3DSA:2.30.38.10 1906 1989 8.1E-24 T 09-03-2017 TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 Pfam PF00975 Thioesterase domain 2198 2337 1.3E-27 T 09-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 Pfam PF00668 Condensation domain 3 291 4.7E-42 T 09-03-2017 IPR001242 Condensation domain TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 Pfam PF00668 Condensation domain 1112 1421 5.2E-52 T 09-03-2017 IPR001242 Condensation domain TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 Gene3D G3DSA:3.40.50.980 1584 1741 5.4E-47 T 09-03-2017 TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 Gene3D G3DSA:3.40.50.980 450 471 2.8E-30 T 09-03-2017 TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 Gene3D G3DSA:3.40.50.980 505 660 2.8E-30 T 09-03-2017 TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 SUPERFAMILY SSF52777 1116 1297 1.78E-41 T 09-03-2017 TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 Gene3D G3DSA:3.40.50.980 661 822 2.8E-29 T 09-03-2017 TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 Gene3D G3DSA:3.40.50.980 1742 1896 3.7E-47 T 09-03-2017 TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 SMART SM00823 Phosphopantetheine attachment site 1026 1096 3.0E-10 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 SMART SM00823 Phosphopantetheine attachment site 2108 2177 5.7E-9 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 SUPERFAMILY SSF47336 1025 1127 1.24E-16 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 SUPERFAMILY SSF52777 1310 1556 4.11E-61 T 09-03-2017 TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 Pfam PF00550 Phosphopantetheine attachment site 1029 1091 1.2E-13 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 Pfam PF00550 Phosphopantetheine attachment site 2109 2169 8.2E-16 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 Gene3D G3DSA:3.30.300.30 908 1008 2.0E-31 T 09-03-2017 TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1051 1066 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 SMART SM00824 Thioesterase 2200 2443 4.6E-5 T 09-03-2017 IPR020802 Polyketide synthase, thioesterase domain GO:0009058|GO:0016788 TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 Pfam PF13745 HxxPF-repeated domain 1443 1534 1.0E-26 T 09-03-2017 TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 ProSitePatterns PS00455 Putative AMP-binding domain signature. 1733 1744 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 548 938 1.7E-102 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 1611 2024 4.7E-133 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 SUPERFAMILY SSF53474 2174 2443 5.41E-56 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2132 2147 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS33870 c0f13819c84dbb2409d5d5c8176e3fda 2448 SUPERFAMILY SSF52777 3 170 1.33E-28 T 09-03-2017 TK78_RS18025 5a1441286a2f7a4e37b5dcec8d950fed 1020 Pfam PF00486 Transcriptional regulatory protein, C terminal 36 98 1.7E-5 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS18025 5a1441286a2f7a4e37b5dcec8d950fed 1020 SUPERFAMILY SSF48452 101 267 2.59E-34 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS18025 5a1441286a2f7a4e37b5dcec8d950fed 1020 SUPERFAMILY SSF52540 272 538 3.84E-27 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18025 5a1441286a2f7a4e37b5dcec8d950fed 1020 SUPERFAMILY SSF48452 850 1004 2.93E-7 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS18025 5a1441286a2f7a4e37b5dcec8d950fed 1020 SMART SM00862 24 98 0.0026 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS18025 5a1441286a2f7a4e37b5dcec8d950fed 1020 Gene3D G3DSA:3.40.50.300 297 340 1.5E-6 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18025 5a1441286a2f7a4e37b5dcec8d950fed 1020 SMART SM00028 819 852 5.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS18025 5a1441286a2f7a4e37b5dcec8d950fed 1020 SMART SM00028 859 892 300.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS18025 5a1441286a2f7a4e37b5dcec8d950fed 1020 SMART SM00028 779 812 16.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS18025 5a1441286a2f7a4e37b5dcec8d950fed 1020 Pfam PF03704 Bacterial transcriptional activator domain 105 249 1.2E-41 T 09-03-2017 IPR005158 Bacterial transcriptional activator domain TK78_RS18025 5a1441286a2f7a4e37b5dcec8d950fed 1020 Gene3D G3DSA:1.10.10.10 35 101 5.4E-5 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS18025 5a1441286a2f7a4e37b5dcec8d950fed 1020 Pfam PF13424 Tetratricopeptide repeat 785 850 2.9E-12 T 09-03-2017 TK78_RS18025 5a1441286a2f7a4e37b5dcec8d950fed 1020 SUPERFAMILY SSF46894 11 98 1.79E-8 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS18025 5a1441286a2f7a4e37b5dcec8d950fed 1020 Gene3D G3DSA:1.25.40.10 712 1013 8.5E-30 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS18025 5a1441286a2f7a4e37b5dcec8d950fed 1020 PRINTS PR00364 Disease resistance protein signature 385 399 4.2E-9 T 09-03-2017 TK78_RS18025 5a1441286a2f7a4e37b5dcec8d950fed 1020 PRINTS PR00364 Disease resistance protein signature 306 321 4.2E-9 T 09-03-2017 TK78_RS18025 5a1441286a2f7a4e37b5dcec8d950fed 1020 PRINTS PR00364 Disease resistance protein signature 470 484 4.2E-9 T 09-03-2017 TK78_RS18025 5a1441286a2f7a4e37b5dcec8d950fed 1020 SMART SM01043 105 249 1.1E-47 T 09-03-2017 IPR005158 Bacterial transcriptional activator domain TK78_RS18025 5a1441286a2f7a4e37b5dcec8d950fed 1020 SUPERFAMILY SSF48452 729 888 2.37E-16 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS18025 5a1441286a2f7a4e37b5dcec8d950fed 1020 Gene3D G3DSA:1.25.40.10 115 228 2.9E-4 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS18025 5a1441286a2f7a4e37b5dcec8d950fed 1020 Gene3D G3DSA:1.25.40.10 271 272 2.9E-4 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS18025 5a1441286a2f7a4e37b5dcec8d950fed 1020 Pfam PF00931 NB-ARC domain 286 542 1.1E-13 T 09-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 TK78_RS31420 4b4ac02b06e0a7325bc05653899dcfe1 164 SMART SM00450 41 138 9.9E-17 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS31420 4b4ac02b06e0a7325bc05653899dcfe1 164 Pfam PF00581 Rhodanese-like domain 51 134 5.4E-13 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS31420 4b4ac02b06e0a7325bc05653899dcfe1 164 SUPERFAMILY SSF52821 39 141 9.04E-25 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS31420 4b4ac02b06e0a7325bc05653899dcfe1 164 Gene3D G3DSA:3.40.250.10 39 141 5.4E-21 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS17355 a281ab94fac70103710edbf78cadbcaf 123 Pfam PF00825 Ribonuclease P 2 117 2.6E-27 T 09-03-2017 IPR000100 Ribonuclease P GO:0000049|GO:0004526|GO:0008033 TK78_RS17355 a281ab94fac70103710edbf78cadbcaf 123 ProDom PD003629 P RIBONUCLEASE COMPONENT HYDROLASE RNASE C5 RNASEP RNA-BINDING PROCESSING ENDONUCLEASE 46 92 4.0E-5 T 09-03-2017 IPR000100 Ribonuclease P GO:0000049|GO:0004526|GO:0008033 TK78_RS17355 a281ab94fac70103710edbf78cadbcaf 123 Hamap MF_00227 Ribonuclease P protein component [rnpA]. 2 120 16.422 T 09-03-2017 IPR000100 Ribonuclease P GO:0000049|GO:0004526|GO:0008033 TK78_RS17355 a281ab94fac70103710edbf78cadbcaf 123 SUPERFAMILY SSF54211 2 118 2.0E-24 T 09-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold TK78_RS17355 a281ab94fac70103710edbf78cadbcaf 123 TIGRFAM TIGR00188 rnpA: ribonuclease P protein component 4 116 2.3E-16 T 09-03-2017 IPR000100 Ribonuclease P GO:0000049|GO:0004526|GO:0008033 TK78_RS17355 a281ab94fac70103710edbf78cadbcaf 123 Gene3D G3DSA:3.30.230.10 2 117 1.5E-32 T 09-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TK78_RS25890 b5a76f569e83611e2025acc4c5a2dcef 437 Pfam PF00534 Glycosyl transferases group 1 252 408 1.1E-29 T 09-03-2017 IPR001296 Glycosyl transferase, family 1 TK78_RS25890 b5a76f569e83611e2025acc4c5a2dcef 437 SUPERFAMILY SSF53756 27 430 6.91E-82 T 09-03-2017 TK78_RS25890 b5a76f569e83611e2025acc4c5a2dcef 437 Gene3D G3DSA:3.40.50.2000 220 407 2.6E-29 T 09-03-2017 TK78_RS25890 b5a76f569e83611e2025acc4c5a2dcef 437 Pfam PF13439 Glycosyltransferase Family 4 39 238 8.4E-28 T 09-03-2017 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 TK78_RS17070 cbf1275b1c24dec1c243954407c14ef0 1172 SUPERFAMILY SSF90123 603 916 9.03E-40 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS17070 cbf1275b1c24dec1c243954407c14ef0 1172 Pfam PF00664 ABC transporter transmembrane region 633 866 1.0E-5 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS17070 cbf1275b1c24dec1c243954407c14ef0 1172 Pfam PF00664 ABC transporter transmembrane region 22 274 3.8E-31 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS17070 cbf1275b1c24dec1c243954407c14ef0 1172 Gene3D G3DSA:3.40.50.300 930 1157 6.3E-63 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17070 cbf1275b1c24dec1c243954407c14ef0 1172 Gene3D G3DSA:3.40.50.300 333 542 6.8E-67 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17070 cbf1275b1c24dec1c243954407c14ef0 1172 SUPERFAMILY SSF52540 330 542 2.77E-66 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17070 cbf1275b1c24dec1c243954407c14ef0 1172 Pfam PF00005 ABC transporter 351 499 1.0E-32 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS17070 cbf1275b1c24dec1c243954407c14ef0 1172 Pfam PF00005 ABC transporter 949 1095 3.6E-27 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS17070 cbf1275b1c24dec1c243954407c14ef0 1172 ProSitePatterns PS00211 ABC transporters family signature. 471 485 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS17070 cbf1275b1c24dec1c243954407c14ef0 1172 TIGRFAM TIGR02868 CydC: thiol reductant ABC exporter, CydC subunit 600 1126 3.3E-198 T 09-03-2017 IPR014223 ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydC GO:0006810|GO:0016021|GO:0042626 TK78_RS17070 cbf1275b1c24dec1c243954407c14ef0 1172 SUPERFAMILY SSF52540 927 1164 6.09E-68 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17070 cbf1275b1c24dec1c243954407c14ef0 1172 SUPERFAMILY SSF90123 2 325 5.89E-57 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS17070 cbf1275b1c24dec1c243954407c14ef0 1172 SMART SM00382 359 545 2.4E-18 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS17070 cbf1275b1c24dec1c243954407c14ef0 1172 SMART SM00382 956 1142 2.3E-16 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS17070 cbf1275b1c24dec1c243954407c14ef0 1172 TIGRFAM TIGR02857 CydD: thiol reductant ABC exporter, CydD subunit 16 541 4.1E-215 T 09-03-2017 IPR014216 ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD GO:0005524|GO:0016020|GO:0042883 TK78_RS17070 cbf1275b1c24dec1c243954407c14ef0 1172 ProSitePatterns PS00211 ABC transporters family signature. 1068 1082 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS17070 cbf1275b1c24dec1c243954407c14ef0 1172 Gene3D G3DSA:1.20.1560.10 6 325 2.6E-49 T 09-03-2017 TK78_RS17070 cbf1275b1c24dec1c243954407c14ef0 1172 Gene3D G3DSA:1.20.1560.10 605 913 1.5E-31 T 09-03-2017 TK78_RS26360 436a33eccce78e5eeb500c5cd60d9263 423 Gene3D G3DSA:3.40.190.10 47 168 7.2E-7 T 09-03-2017 TK78_RS26360 436a33eccce78e5eeb500c5cd60d9263 423 Pfam PF13416 Bacterial extracellular solute-binding protein 57 359 8.3E-54 T 09-03-2017 TK78_RS26360 436a33eccce78e5eeb500c5cd60d9263 423 SUPERFAMILY SSF53850 39 410 2.35E-90 T 09-03-2017 TK78_RS26360 436a33eccce78e5eeb500c5cd60d9263 423 Gene3D G3DSA:3.40.190.10 169 355 6.3E-51 T 09-03-2017 TK78_RS08165 8fc4b9cf275248b9284329206c5391a2 79 Hamap MF_00088 UPF0109 protein . 2 73 21.89 T 09-03-2017 IPR020627 Uncharacterised protein family UPF0109 TK78_RS08165 8fc4b9cf275248b9284329206c5391a2 79 Pfam PF13083 KH domain 3 64 1.7E-19 T 09-03-2017 TK78_RS08165 8fc4b9cf275248b9284329206c5391a2 79 Gene3D G3DSA:3.30.300.120 5 63 7.8E-6 T 09-03-2017 TK78_RS08165 8fc4b9cf275248b9284329206c5391a2 79 SUPERFAMILY SSF54814 16 62 1.18E-8 T 09-03-2017 IPR009019 K homology domain, prokaryotic type GO:0003723 TK78_RS03230 ef0d020f0d59b665502d7f07e0d38ffc 211 SUPERFAMILY SSF52317 2 183 5.81E-47 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS03230 ef0d020f0d59b665502d7f07e0d38ffc 211 Pfam PF01965 DJ-1/PfpI family 2 162 3.1E-28 T 09-03-2017 IPR002818 DJ-1/PfpI TK78_RS03230 ef0d020f0d59b665502d7f07e0d38ffc 211 Gene3D G3DSA:3.40.50.880 2 209 2.0E-67 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS09990 8c3e131d359b0397feebe94b558240a8 245 SMART SM00448 19 129 8.5E-40 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS09990 8c3e131d359b0397feebe94b558240a8 245 SUPERFAMILY SSF46894 147 241 1.7E-26 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS09990 8c3e131d359b0397feebe94b558240a8 245 SUPERFAMILY SSF52172 15 138 3.42E-40 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS09990 8c3e131d359b0397feebe94b558240a8 245 Gene3D G3DSA:3.40.50.2300 17 137 4.0E-38 T 09-03-2017 TK78_RS09990 8c3e131d359b0397feebe94b558240a8 245 Pfam PF00072 Response regulator receiver domain 21 129 2.4E-25 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS09990 8c3e131d359b0397feebe94b558240a8 245 SMART SM00862 169 240 4.2E-25 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS09990 8c3e131d359b0397feebe94b558240a8 245 Pfam PF00486 Transcriptional regulatory protein, C terminal 170 240 1.2E-23 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS09990 8c3e131d359b0397feebe94b558240a8 245 Gene3D G3DSA:1.10.10.10 147 242 1.7E-31 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS00670 f793b6127dcd077651294a8c9780a5b2 254 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 89 100 2.2E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS00670 f793b6127dcd077651294a8c9780a5b2 254 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 140 148 2.2E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS00670 f793b6127dcd077651294a8c9780a5b2 254 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 160 179 2.2E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS00670 f793b6127dcd077651294a8c9780a5b2 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 134 150 9.3E-41 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS00670 f793b6127dcd077651294a8c9780a5b2 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 9.3E-41 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS00670 f793b6127dcd077651294a8c9780a5b2 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 89 100 9.3E-41 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS00670 f793b6127dcd077651294a8c9780a5b2 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 181 198 9.3E-41 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS00670 f793b6127dcd077651294a8c9780a5b2 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 216 236 9.3E-41 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS00670 f793b6127dcd077651294a8c9780a5b2 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 160 179 9.3E-41 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS00670 f793b6127dcd077651294a8c9780a5b2 254 Gene3D G3DSA:3.40.50.720 2 252 1.3E-75 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS00670 f793b6127dcd077651294a8c9780a5b2 254 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 147 175 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS00670 f793b6127dcd077651294a8c9780a5b2 254 SUPERFAMILY SSF51735 1 252 7.17E-71 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS00670 f793b6127dcd077651294a8c9780a5b2 254 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 13 252 2.1E-53 T 09-03-2017 TK78_RS18535 20a070a08fdffde9dd904e64070b0295 186 SUPERFAMILY SSF55729 1 166 6.86E-25 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS18535 20a070a08fdffde9dd904e64070b0295 186 Pfam PF00583 Acetyltransferase (GNAT) family 73 160 1.2E-11 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS18535 20a070a08fdffde9dd904e64070b0295 186 Gene3D G3DSA:3.40.630.30 1 169 5.0E-26 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS28670 f009052dadb3978605b4d7193f4b3de4 427 SMART SM00363 191 251 2.6E-8 T 09-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 TK78_RS28670 f009052dadb3978605b4d7193f4b3de4 427 TIGRFAM TIGR00093 TIGR00093: pseudouridine synthase 256 414 6.8E-43 T 09-03-2017 IPR000748 Pseudouridine synthase, RsuA/RluB/E/F GO:0001522|GO:0003723|GO:0009451|GO:0016866 TK78_RS28670 f009052dadb3978605b4d7193f4b3de4 427 SUPERFAMILY SSF55120 235 423 3.08E-43 T 09-03-2017 IPR020103 Pseudouridine synthase, catalytic domain GO:0001522|GO:0003723|GO:0009451|GO:0009982 TK78_RS28670 f009052dadb3978605b4d7193f4b3de4 427 Pfam PF01479 S4 domain 191 238 6.3E-12 T 09-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 TK78_RS28670 f009052dadb3978605b4d7193f4b3de4 427 Gene3D G3DSA:3.10.290.10 189 249 2.4E-20 T 09-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 TK78_RS28670 f009052dadb3978605b4d7193f4b3de4 427 ProSitePatterns PS01149 Rsu family of pseudouridine synthase signature. 289 303 - T 09-03-2017 IPR018496 Pseudouridine synthase, RsuA/RluB/E/F, conserved site GO:0001522|GO:0003723|GO:0009451|GO:0016866 TK78_RS28670 f009052dadb3978605b4d7193f4b3de4 427 Pfam PF00849 RNA pseudouridylate synthase 253 383 4.8E-23 T 09-03-2017 IPR006145 Pseudouridine synthase, RsuA/RluB/C/D/E/F GO:0001522|GO:0003723|GO:0009451|GO:0009982 TK78_RS28670 f009052dadb3978605b4d7193f4b3de4 427 SUPERFAMILY SSF55174 187 255 5.49E-12 T 09-03-2017 TK78_RS28480 a9d9a78795d64db665a9e17ee628e6bc 381 SMART SM00387 287 381 4.6E-12 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS28480 a9d9a78795d64db665a9e17ee628e6bc 381 SMART SM00065 24 176 4.0E-20 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS28480 a9d9a78795d64db665a9e17ee628e6bc 381 Gene3D G3DSA:3.30.450.40 18 174 2.9E-32 T 09-03-2017 IPR029016 GAF domain-like TK78_RS28480 a9d9a78795d64db665a9e17ee628e6bc 381 Pfam PF13185 GAF domain 24 166 2.0E-21 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS28480 a9d9a78795d64db665a9e17ee628e6bc 381 SUPERFAMILY SSF55874 252 379 2.1E-20 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS28480 a9d9a78795d64db665a9e17ee628e6bc 381 Gene3D G3DSA:3.30.565.10 250 379 7.6E-14 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS28480 a9d9a78795d64db665a9e17ee628e6bc 381 Pfam PF07730 Histidine kinase 183 250 1.8E-18 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS28480 a9d9a78795d64db665a9e17ee628e6bc 381 PRINTS PR00344 Bacterial sensor protein C-terminal signature 323 337 2.0E-6 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS28480 a9d9a78795d64db665a9e17ee628e6bc 381 PRINTS PR00344 Bacterial sensor protein C-terminal signature 342 360 2.0E-6 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS28480 a9d9a78795d64db665a9e17ee628e6bc 381 PRINTS PR00344 Bacterial sensor protein C-terminal signature 366 379 2.0E-6 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS28480 a9d9a78795d64db665a9e17ee628e6bc 381 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 289 379 2.9E-9 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS28480 a9d9a78795d64db665a9e17ee628e6bc 381 SUPERFAMILY SSF55781 11 179 2.62E-31 T 09-03-2017 IPR029016 GAF domain-like TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SUPERFAMILY SSF51735 1478 1732 1.22E-44 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 Pfam PF00550 Phosphopantetheine attachment site 3540 3606 2.1E-10 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 Pfam PF00550 Phosphopantetheine attachment site 1767 1833 4.9E-9 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SMART SM00826 969 1131 1.4E-72 T 09-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SMART SM00826 2773 2942 1.7E-67 T 09-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SUPERFAMILY SSF52151 2384 2432 7.06E-59 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SUPERFAMILY SSF52151 2594 2678 7.06E-59 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SUPERFAMILY SSF52151 2460 2533 7.06E-59 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 3254 3432 8.9E-56 T 09-03-2017 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1480 1660 5.6E-60 T 09-03-2017 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SUPERFAMILY SSF55048 2532 2593 5.49E-9 T 09-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 Pfam PF08659 KR domain 3254 3431 4.4E-55 T 09-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 Pfam PF08659 KR domain 1480 1658 6.0E-60 T 09-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SMART SM00825 Beta-ketoacyl synthase 1865 2277 7.5E-200 T 09-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SMART SM00825 Beta-ketoacyl synthase 40 467 5.5E-226 T 09-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 2107 2224 4.6E-39 T 09-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 296 413 1.7E-44 T 09-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3565 3580 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SUPERFAMILY SSF51735 3062 3244 6.3E-20 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SUPERFAMILY SSF51735 1251 1444 3.35E-27 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SMART SM01294 1766 1833 2.0E-4 T 09-03-2017 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SMART SM01294 3539 3606 7.4E-4 T 09-03-2017 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SMART SM00823 Phosphopantetheine attachment site 3538 3610 4.6E-29 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SMART SM00823 Phosphopantetheine attachment site 1765 1837 9.0E-29 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 2012 2028 - T 09-03-2017 IPR018201 Beta-ketoacyl synthase, active site TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 Gene3D G3DSA:3.40.366.10 2592 2698 8.3E-65 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 Gene3D G3DSA:3.40.366.10 2378 2527 8.3E-65 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2386 2695 8.7E-95 T 09-03-2017 IPR020801 Polyketide synthase, acyl transferase domain TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 593 902 2.0E-98 T 09-03-2017 IPR020801 Polyketide synthase, acyl transferase domain TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SUPERFAMILY SSF55048 731 793 8.5E-9 T 09-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SUPERFAMILY SSF51735 3252 3488 2.12E-45 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 Gene3D G3DSA:3.40.50.720 1479 1686 6.0E-35 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 Gene3D G3DSA:3.40.50.720 3255 3434 4.1E-38 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SUPERFAMILY SSF47336 1763 1878 2.09E-21 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 Gene3D G3DSA:3.40.47.10 33 300 4.3E-92 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 Gene3D G3DSA:3.40.47.10 1865 2111 6.7E-85 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SUPERFAMILY SSF47336 3531 3616 8.38E-21 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1863 2099 2.1E-82 T 09-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 39 288 5.0E-90 T 09-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 Gene3D G3DSA:3.40.366.10 792 902 8.7E-64 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 Gene3D G3DSA:3.40.366.10 589 726 8.7E-64 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 Gene3D G3DSA:3.40.47.10 301 465 5.5E-64 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 Gene3D G3DSA:3.40.47.10 2112 2277 3.5E-59 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SUPERFAMILY SSF52151 794 891 3.66E-59 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SUPERFAMILY SSF52151 589 732 3.66E-59 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 Gene3D G3DSA:1.10.1200.10 1764 1838 2.5E-21 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 Gene3D G3DSA:1.10.1200.10 3537 3610 8.7E-21 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 Pfam PF00698 Acyl transferase domain 2385 2676 4.1E-41 T 09-03-2017 IPR014043 Acyl transferase TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 Pfam PF00698 Acyl transferase domain 592 919 1.5E-72 T 09-03-2017 IPR014043 Acyl transferase TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SUPERFAMILY SSF53901 34 410 6.63E-105 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 Pfam PF14765 Polyketide synthase dehydratase 969 1243 5.9E-56 T 09-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 Pfam PF14765 Polyketide synthase dehydratase 2773 3048 5.1E-47 T 09-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 Pfam PF08990 Erythronolide synthase docking 7 31 2.1E-10 T 09-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1792 1807 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 201 217 - T 09-03-2017 IPR018201 Beta-ketoacyl synthase, active site TK78_RS07080 f7b67da38dc4b2dcbbf1d6cada37118e 3695 SUPERFAMILY SSF53901 1861 2220 8.35E-99 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS02560 d703eae9231401cd67c6cf7438fe3819 142 PIRSF PIRSF006246 1 133 2.1E-53 T 09-03-2017 IPR003190 Aspartate decarboxylase GO:0004068|GO:0006523 KEGG: 00410+4.1.1.11|KEGG: 00770+4.1.1.11|MetaCyc: PWY-5155 TK78_RS02560 d703eae9231401cd67c6cf7438fe3819 142 Gene3D G3DSA:2.40.40.20 1 118 6.3E-56 T 09-03-2017 TK78_RS02560 d703eae9231401cd67c6cf7438fe3819 142 ProDom PD009294 ASPARTATE 1-DECARBOXYLASE DECARBOXYLASE CHAIN LYASE ALPHA ALPHA- CONTAINS: PRECURSOR BETA 5 114 3.0E-45 T 09-03-2017 IPR003190 Aspartate decarboxylase GO:0004068|GO:0006523 KEGG: 00410+4.1.1.11|KEGG: 00770+4.1.1.11|MetaCyc: PWY-5155 TK78_RS02560 d703eae9231401cd67c6cf7438fe3819 142 TIGRFAM TIGR00223 panD: aspartate 1-decarboxylase 1 119 4.0E-48 T 09-03-2017 IPR003190 Aspartate decarboxylase GO:0004068|GO:0006523 KEGG: 00410+4.1.1.11|KEGG: 00770+4.1.1.11|MetaCyc: PWY-5155 TK78_RS02560 d703eae9231401cd67c6cf7438fe3819 142 Pfam PF02261 Aspartate decarboxylase 1 114 1.1E-51 T 09-03-2017 IPR003190 Aspartate decarboxylase GO:0004068|GO:0006523 KEGG: 00410+4.1.1.11|KEGG: 00770+4.1.1.11|MetaCyc: PWY-5155 TK78_RS02560 d703eae9231401cd67c6cf7438fe3819 142 SUPERFAMILY SSF50692 1 116 4.23E-49 T 09-03-2017 IPR009010 Aspartate decarboxylase-like domain TK78_RS02560 d703eae9231401cd67c6cf7438fe3819 142 Hamap MF_00446 Aspartate 1-decarboxylase [panD]. 1 130 74.768 T 09-03-2017 IPR003190 Aspartate decarboxylase GO:0004068|GO:0006523 KEGG: 00410+4.1.1.11|KEGG: 00770+4.1.1.11|MetaCyc: PWY-5155 TK78_RS22975 37075f5a3fed0bcb6eb97f0451a7bb22 366 SMART SM00382 35 219 3.8E-18 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS22975 37075f5a3fed0bcb6eb97f0451a7bb22 366 Pfam PF08402 TOBE domain 280 350 1.3E-9 T 09-03-2017 IPR013611 Transport-associated OB, type 2 GO:0005215|GO:0005524|GO:0006810|GO:0016820|GO:0043190 TK78_RS22975 37075f5a3fed0bcb6eb97f0451a7bb22 366 SUPERFAMILY SSF52540 11 251 1.9E-82 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22975 37075f5a3fed0bcb6eb97f0451a7bb22 366 SUPERFAMILY SSF50331 246 355 8.22E-13 T 09-03-2017 IPR008995 Molybdate/tungstate binding, C-terminal TK78_RS22975 37075f5a3fed0bcb6eb97f0451a7bb22 366 Pfam PF00005 ABC transporter 26 168 4.9E-32 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS22975 37075f5a3fed0bcb6eb97f0451a7bb22 366 ProSitePatterns PS00211 ABC transporters family signature. 141 155 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS22975 37075f5a3fed0bcb6eb97f0451a7bb22 366 Gene3D G3DSA:3.40.50.300 6 244 1.0E-78 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS16955 cc60466756ed8da5dfb859a391aba7e4 493 Gene3D G3DSA:3.90.230.10 229 488 1.5E-66 T 09-03-2017 IPR000994 Peptidase M24, structural domain TK78_RS16955 cc60466756ed8da5dfb859a391aba7e4 493 SMART SM01011 57 198 1.5E-40 T 09-03-2017 IPR007865 Aminopeptidase P, N-terminal GO:0004177|GO:0030145 TK78_RS16955 cc60466756ed8da5dfb859a391aba7e4 493 SUPERFAMILY SSF55920 225 488 1.7E-67 T 09-03-2017 IPR000994 Peptidase M24, structural domain TK78_RS16955 cc60466756ed8da5dfb859a391aba7e4 493 Pfam PF00557 Metallopeptidase family M24 231 467 2.9E-49 T 09-03-2017 IPR000994 Peptidase M24, structural domain TK78_RS16955 cc60466756ed8da5dfb859a391aba7e4 493 Pfam PF05195 Aminopeptidase P, N-terminal domain 64 184 1.5E-19 T 09-03-2017 IPR007865 Aminopeptidase P, N-terminal GO:0004177|GO:0030145 TK78_RS16955 cc60466756ed8da5dfb859a391aba7e4 493 ProSitePatterns PS00491 Aminopeptidase P and proline dipeptidase signature. 401 413 - T 09-03-2017 IPR001131 Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site TK78_RS16955 cc60466756ed8da5dfb859a391aba7e4 493 SUPERFAMILY SSF53092 56 224 2.72E-28 T 09-03-2017 IPR028980 Creatinase/Aminopeptidase P, N-terminal TK78_RS16955 cc60466756ed8da5dfb859a391aba7e4 493 Gene3D G3DSA:3.40.350.10 59 228 5.9E-38 T 09-03-2017 IPR029149 Creatinase/Aminopeptidase P/Spt16, N-terminal TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 ProSitePatterns PS00154 E1-E2 ATPases phosphorylation site. 434 440 - T 09-03-2017 IPR018303 P-type ATPase, phosphorylation site Reactome: R-HSA-936837 TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 Pfam PF00403 Heavy-metal-associated domain 1 55 1.7E-13 T 09-03-2017 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 Pfam PF00122 E1-E2 ATPase 205 423 8.9E-67 T 09-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 282 296 3.5E-23 T 09-03-2017 TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 432 446 3.5E-23 T 09-03-2017 TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 579 589 3.5E-23 T 09-03-2017 TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 632 651 3.5E-23 T 09-03-2017 TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 655 667 3.5E-23 T 09-03-2017 TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 Gene3D G3DSA:3.30.70.100 1 57 9.2E-20 T 09-03-2017 TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 SUPERFAMILY SSF55008 1 59 4.06E-16 T 09-03-2017 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 SUPERFAMILY SSF81653 237 332 2.09E-26 T 09-03-2017 TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 PRINTS PR00943 Copper-transporting ATPase signature 609 626 2.8E-7 T 09-03-2017 TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 PRINTS PR00943 Copper-transporting ATPase signature 222 240 2.8E-7 T 09-03-2017 TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 PRINTS PR00943 Copper-transporting ATPase signature 355 369 2.8E-7 T 09-03-2017 TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 PRINTS PR00943 Copper-transporting ATPase signature 202 221 2.8E-7 T 09-03-2017 TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 PRINTS PR00943 Copper-transporting ATPase signature 8 22 2.8E-7 T 09-03-2017 TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 TIGRFAM TIGR01525 ATPase-IB_hvy: heavy metal translocating P-type ATPase 151 734 3.6E-179 T 09-03-2017 IPR027256 P-type ATPase, subfamily IB GO:0006812|GO:0016021|GO:0019829 Reactome: R-HSA-936837 TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 Gene3D G3DSA:3.40.1110.10 449 559 1.2E-20 T 09-03-2017 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 Reactome: R-HSA-936837 TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 Pfam PF00702 haloacid dehalogenase-like hydrolase 429 646 1.5E-44 T 09-03-2017 TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 206 713 3.1E-84 T 09-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 ProSitePatterns PS01229 Hypothetical cof family signature 2. 632 654 - T 09-03-2017 TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 Gene3D G3DSA:3.40.50.1000 560 700 3.2E-50 T 09-03-2017 IPR023214 HAD-like domain TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 Gene3D G3DSA:3.40.50.1000 403 448 3.2E-50 T 09-03-2017 IPR023214 HAD-like domain TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 SUPERFAMILY SSF56784 430 450 2.31E-57 T 09-03-2017 IPR023214 HAD-like domain TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 SUPERFAMILY SSF56784 489 732 2.31E-57 T 09-03-2017 IPR023214 HAD-like domain TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 TIGRFAM TIGR01511 ATPase-IB1_Cu: copper-translocating P-type ATPase 196 735 1.2E-153 T 09-03-2017 TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 Gene3D G3DSA:2.70.150.10 195 333 5.5E-31 T 09-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 SUPERFAMILY SSF81665 202 236 1.83E-13 T 09-03-2017 TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 SUPERFAMILY SSF81665 333 426 1.83E-13 T 09-03-2017 TK78_RS14765 5ec7de622cd1ab6ea014b44f9a2bf0af 740 SUPERFAMILY SSF81665 681 709 1.83E-13 T 09-03-2017 TK78_RS06010 86155a9bbba270eeb294cbd91be91947 399 SUPERFAMILY SSF46785 11 71 1.89E-11 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS06010 86155a9bbba270eeb294cbd91be91947 399 ProSitePatterns PS01125 ROK family signature. 215 242 - T 09-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 TK78_RS06010 86155a9bbba270eeb294cbd91be91947 399 Pfam PF00480 ROK family 82 378 4.2E-60 T 09-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 TK78_RS06010 86155a9bbba270eeb294cbd91be91947 399 Gene3D G3DSA:1.10.10.10 11 74 1.2E-14 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS06010 86155a9bbba270eeb294cbd91be91947 399 Pfam PF12802 MarR family 17 68 2.4E-8 T 09-03-2017 TK78_RS06010 86155a9bbba270eeb294cbd91be91947 399 Gene3D G3DSA:3.30.420.40 77 219 1.0E-43 T 09-03-2017 TK78_RS06010 86155a9bbba270eeb294cbd91be91947 399 Gene3D G3DSA:3.30.420.40 220 360 1.1E-48 T 09-03-2017 TK78_RS06010 86155a9bbba270eeb294cbd91be91947 399 SUPERFAMILY SSF53067 79 383 6.95E-61 T 09-03-2017 TK78_RS24155 68b0af8713c69fc7630573cf419f9323 443 SUPERFAMILY SSF53850 21 438 2.01E-65 T 09-03-2017 TK78_RS24155 68b0af8713c69fc7630573cf419f9323 443 Pfam PF13416 Bacterial extracellular solute-binding protein 60 383 3.3E-37 T 09-03-2017 TK78_RS24155 68b0af8713c69fc7630573cf419f9323 443 Gene3D G3DSA:3.40.190.10 336 390 4.5E-40 T 09-03-2017 TK78_RS24155 68b0af8713c69fc7630573cf419f9323 443 Gene3D G3DSA:3.40.190.10 40 156 4.5E-40 T 09-03-2017 TK78_RS24155 68b0af8713c69fc7630573cf419f9323 443 Gene3D G3DSA:3.40.190.10 157 335 4.1E-35 T 09-03-2017 TK78_RS22120 e0967181f23c15909871ba6e6d69f5bb 206 Pfam PF13302 Acetyltransferase (GNAT) domain 10 150 5.0E-28 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS22120 e0967181f23c15909871ba6e6d69f5bb 206 Gene3D G3DSA:3.40.630.30 1 174 5.2E-48 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS22120 e0967181f23c15909871ba6e6d69f5bb 206 SUPERFAMILY SSF55729 1 174 2.98E-41 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS01805 b6a1d5d16cc2163f816f4de39846a476 386 TIGRFAM TIGR02635 RhaI_grampos: L-rhamnose isomerase 6 376 2.9E-198 T 09-03-2017 IPR013457 Rhamnose isomerase-related TK78_RS01805 b6a1d5d16cc2163f816f4de39846a476 386 SUPERFAMILY SSF51658 25 359 1.61E-93 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS01805 b6a1d5d16cc2163f816f4de39846a476 386 Gene3D G3DSA:3.20.20.150 16 372 2.2E-87 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS01805 b6a1d5d16cc2163f816f4de39846a476 386 Pfam PF06134 L-rhamnose isomerase (RhaA) 80 334 2.3E-6 T 09-03-2017 IPR009308 Rhamnose isomerase GO:0008740|GO:0019299|GO:0030145 KEGG: 00051+5.3.1.14 TK78_RS11640 df01adc4b4ab72463868c3604c2d06c2 438 Gene3D G3DSA:3.40.50.2300 3 128 1.1E-10 T 09-03-2017 TK78_RS11640 df01adc4b4ab72463868c3604c2d06c2 438 SUPERFAMILY SSF52540 150 385 2.25E-34 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS11640 df01adc4b4ab72463868c3604c2d06c2 438 Gene3D G3DSA:3.40.50.300 149 385 4.3E-40 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS11640 df01adc4b4ab72463868c3604c2d06c2 438 Pfam PF01656 CobQ/CobB/MinD/ParA nucleotide binding domain 152 330 7.3E-23 T 09-03-2017 IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain TK78_RS11640 df01adc4b4ab72463868c3604c2d06c2 438 SUPERFAMILY SSF52172 2 131 1.07E-10 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS34110 5b333f2965c7df67cbb9be0d58299225 515 PRINTS PR00111 Alpha/beta hydrolase fold signature 385 398 5.0E-6 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS34110 5b333f2965c7df67cbb9be0d58299225 515 PRINTS PR00111 Alpha/beta hydrolase fold signature 328 343 5.0E-6 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS34110 5b333f2965c7df67cbb9be0d58299225 515 PRINTS PR00111 Alpha/beta hydrolase fold signature 371 384 5.0E-6 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS34110 5b333f2965c7df67cbb9be0d58299225 515 Pfam PF00561 alpha/beta hydrolase fold 22 266 1.0E-22 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS34110 5b333f2965c7df67cbb9be0d58299225 515 Pfam PF00561 alpha/beta hydrolase fold 303 403 7.7E-19 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS34110 5b333f2965c7df67cbb9be0d58299225 515 Gene3D G3DSA:3.40.50.1820 435 504 1.8E-15 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS34110 5b333f2965c7df67cbb9be0d58299225 515 Gene3D G3DSA:3.40.50.1820 286 410 1.1E-41 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS34110 5b333f2965c7df67cbb9be0d58299225 515 Gene3D G3DSA:3.40.50.1820 2 279 5.2E-52 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS34110 5b333f2965c7df67cbb9be0d58299225 515 SUPERFAMILY SSF53474 4 279 7.77E-51 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS34110 5b333f2965c7df67cbb9be0d58299225 515 SUPERFAMILY SSF53474 286 504 1.46E-56 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS05535 db74b65a38845e768e8469c27dc1a104 279 SUPERFAMILY SSF52540 6 234 3.55E-61 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS05535 db74b65a38845e768e8469c27dc1a104 279 ProSitePatterns PS00211 ABC transporters family signature. 144 158 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS05535 db74b65a38845e768e8469c27dc1a104 279 Pfam PF00005 ABC transporter 25 171 1.4E-30 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS05535 db74b65a38845e768e8469c27dc1a104 279 SMART SM00382 32 221 4.8E-16 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS05535 db74b65a38845e768e8469c27dc1a104 279 Gene3D G3DSA:3.40.50.300 3 244 6.1E-65 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13205 64055d2b1a7ff09124ac62df3785dcf8 156 SUPERFAMILY SSF47973 1 149 7.59E-57 T 09-03-2017 IPR023798 Ribosomal protein S7 domain TK78_RS13205 64055d2b1a7ff09124ac62df3785dcf8 156 Gene3D G3DSA:1.10.455.10 8 156 1.4E-60 T 09-03-2017 IPR023798 Ribosomal protein S7 domain TK78_RS13205 64055d2b1a7ff09124ac62df3785dcf8 156 ProSitePatterns PS00052 Ribosomal protein S7 signature. 20 46 - T 09-03-2017 IPR020606 Ribosomal protein S7, conserved site GO:0003723|GO:0003735|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13205 64055d2b1a7ff09124ac62df3785dcf8 156 PIRSF PIRSF002122 7 156 1.0E-55 T 09-03-2017 IPR000235 Ribosomal protein S5/S7 GO:0006412 TK78_RS13205 64055d2b1a7ff09124ac62df3785dcf8 156 TIGRFAM TIGR01029 rpsG_bact: ribosomal protein uS7 3 156 2.6E-64 T 09-03-2017 IPR005717 Ribosomal protein S7, bacterial/organellar-type GO:0003735|GO:0006412|GO:0015935 TK78_RS13205 64055d2b1a7ff09124ac62df3785dcf8 156 Hamap MF_00480_B 30S ribosomal protein S7 [rpsG]. 1 156 34.635 T 09-03-2017 IPR005717 Ribosomal protein S7, bacterial/organellar-type GO:0003735|GO:0006412|GO:0015935 TK78_RS13205 64055d2b1a7ff09124ac62df3785dcf8 156 Pfam PF00177 Ribosomal protein S7p/S5e 1 149 1.5E-59 T 09-03-2017 IPR023798 Ribosomal protein S7 domain TK78_RS24845 871bf63acc2940c7742172c040497600 321 Pfam PF07650 KH domain 228 310 1.6E-16 T 09-03-2017 IPR004044 K Homology domain, type 2 GO:0003723 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS24845 871bf63acc2940c7742172c040497600 321 SUPERFAMILY SSF52540 26 233 2.16E-39 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24845 871bf63acc2940c7742172c040497600 321 TIGRFAM TIGR00436 era: GTP-binding protein Era 23 304 1.5E-65 T 09-03-2017 IPR005662 GTP-binding protein Era GO:0003723|GO:0005525|GO:0005622 TK78_RS24845 871bf63acc2940c7742172c040497600 321 Hamap MF_00367 GTPase Era [era]. 20 321 34.552 T 09-03-2017 IPR005662 GTP-binding protein Era GO:0003723|GO:0005525|GO:0005622 TK78_RS24845 871bf63acc2940c7742172c040497600 321 Pfam PF01926 50S ribosome-binding GTPase 26 139 1.2E-20 T 09-03-2017 IPR006073 GTP binding domain GO:0005525 TK78_RS24845 871bf63acc2940c7742172c040497600 321 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 27 180 1.8E-17 T 09-03-2017 IPR005225 Small GTP-binding protein domain GO:0005525 TK78_RS24845 871bf63acc2940c7742172c040497600 321 Gene3D G3DSA:3.30.300.20 209 318 1.2E-35 T 09-03-2017 IPR015946 K homology domain-like, alpha/beta TK78_RS24845 871bf63acc2940c7742172c040497600 321 SUPERFAMILY SSF54814 202 321 2.62E-34 T 09-03-2017 IPR009019 K homology domain, prokaryotic type GO:0003723 TK78_RS24845 871bf63acc2940c7742172c040497600 321 Gene3D G3DSA:3.40.50.300 13 194 4.0E-37 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS14015 ab8e93fd9213b3c7527d63704ac64c7b 197 Pfam PF04542 Sigma-70 region 2 28 94 7.1E-10 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS14015 ab8e93fd9213b3c7527d63704ac64c7b 197 Gene3D G3DSA:1.10.10.10 130 178 1.6E-5 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS14015 ab8e93fd9213b3c7527d63704ac64c7b 197 Gene3D G3DSA:1.10.1740.10 11 113 1.4E-14 T 09-03-2017 TK78_RS14015 ab8e93fd9213b3c7527d63704ac64c7b 197 Pfam PF08281 Sigma-70, region 4 130 176 4.0E-6 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS14015 ab8e93fd9213b3c7527d63704ac64c7b 197 SUPERFAMILY SSF88946 10 109 1.53E-14 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS14015 ab8e93fd9213b3c7527d63704ac64c7b 197 SUPERFAMILY SSF88659 126 178 5.23E-6 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS14015 ab8e93fd9213b3c7527d63704ac64c7b 197 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 24 177 1.2E-15 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS09610 749dca8e823bfc1cfe89cfad689a8f81 107 SUPERFAMILY SSF52091 2 97 2.94E-21 T 09-03-2017 IPR002645 STAS domain TK78_RS09610 749dca8e823bfc1cfe89cfad689a8f81 107 Pfam PF13466 STAS domain 10 89 2.4E-15 T 09-03-2017 IPR002645 STAS domain TK78_RS09610 749dca8e823bfc1cfe89cfad689a8f81 107 Gene3D G3DSA:3.30.750.24 2 98 3.0E-26 T 09-03-2017 IPR002645 STAS domain TK78_RS09610 749dca8e823bfc1cfe89cfad689a8f81 107 TIGRFAM TIGR00377 ant_ant_sig: anti-anti-sigma factor 2 96 1.1E-16 T 09-03-2017 IPR003658 Anti-sigma factor antagonist GO:0006355|GO:0045152 TK78_RS32090 11b5debf13e28373245771ba0b58268a 369 Pfam PF13407 Periplasmic binding protein domain 43 322 1.1E-65 T 09-03-2017 IPR025997 Periplasmic binding protein TK78_RS32090 11b5debf13e28373245771ba0b58268a 369 SUPERFAMILY SSF53822 41 356 8.05E-71 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS32090 11b5debf13e28373245771ba0b58268a 369 Gene3D G3DSA:3.40.50.2300 155 355 2.2E-35 T 09-03-2017 TK78_RS32090 11b5debf13e28373245771ba0b58268a 369 Gene3D G3DSA:3.40.50.2300 42 154 1.1E-34 T 09-03-2017 TK78_RS16480 4d02418a61ff82de5fb4c92f97aa7e8e 249 TIGRFAM TIGR01465 cobM_cbiF: precorrin-4 C11-methyltransferase 3 243 2.2E-87 T 09-03-2017 IPR006362 Cobalamin (vitamin B12) biosynthesis CobM/CbiF, precorrin-4 C11-methyltransferase GO:0009236|GO:0046026 TK78_RS16480 4d02418a61ff82de5fb4c92f97aa7e8e 249 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 2 208 7.2E-39 T 09-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS16480 4d02418a61ff82de5fb4c92f97aa7e8e 249 ProSitePatterns PS00839 Uroporphyrin-III C-methyltransferase signature 1. 6 20 - T 09-03-2017 IPR003043 Uroporphiryn-III C-methyltransferase, conserved site GO:0008168|GO:0055114 KEGG: 00270+2.1.1.10|KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5441|MetaCyc: PWY-702|MetaCyc: PWY-7377 TK78_RS16480 4d02418a61ff82de5fb4c92f97aa7e8e 249 Gene3D G3DSA:3.40.1010.10 2 110 1.4E-33 T 09-03-2017 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS16480 4d02418a61ff82de5fb4c92f97aa7e8e 249 SUPERFAMILY SSF53790 2 233 2.36E-59 T 09-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS16480 4d02418a61ff82de5fb4c92f97aa7e8e 249 ProSitePatterns PS00840 Uroporphyrin-III C-methyltransferase signature 2. 76 109 - T 09-03-2017 IPR003043 Uroporphiryn-III C-methyltransferase, conserved site GO:0008168|GO:0055114 KEGG: 00270+2.1.1.10|KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5441|MetaCyc: PWY-702|MetaCyc: PWY-7377 TK78_RS16480 4d02418a61ff82de5fb4c92f97aa7e8e 249 Gene3D G3DSA:3.30.950.10 111 232 4.8E-31 T 09-03-2017 IPR014776 Tetrapyrrole methylase, subdomain 2 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS27660 1bcff882cb4ab0d8110bf2827cf69abe 863 SMART SM00490 244 342 1.9E-10 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS27660 1bcff882cb4ab0d8110bf2827cf69abe 863 SUPERFAMILY SSF52540 197 352 1.76E-46 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27660 1bcff882cb4ab0d8110bf2827cf69abe 863 SUPERFAMILY SSF52540 20 170 1.76E-46 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27660 1bcff882cb4ab0d8110bf2827cf69abe 863 Pfam PF04408 Helicase associated domain (HA2) 403 463 2.9E-10 T 09-03-2017 IPR007502 Helicase-associated domain GO:0004386 TK78_RS27660 1bcff882cb4ab0d8110bf2827cf69abe 863 TIGRFAM TIGR01970 DEAH_box_HrpB: ATP-dependent helicase HrpB 10 858 5.1E-227 T 09-03-2017 IPR010225 RNA helicase, ATP-dependent DEAH box, HrpB-type TK78_RS27660 1bcff882cb4ab0d8110bf2827cf69abe 863 SMART SM00847 402 495 5.6E-12 T 09-03-2017 IPR007502 Helicase-associated domain GO:0004386 TK78_RS27660 1bcff882cb4ab0d8110bf2827cf69abe 863 SMART SM00487 3 194 4.0E-18 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS27660 1bcff882cb4ab0d8110bf2827cf69abe 863 Pfam PF13245 Part of AAA domain 18 76 4.2E-6 T 09-03-2017 TK78_RS27660 1bcff882cb4ab0d8110bf2827cf69abe 863 Pfam PF00271 Helicase conserved C-terminal domain 226 340 7.2E-9 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS27660 1bcff882cb4ab0d8110bf2827cf69abe 863 PIRSF PIRSF005496 5 861 1.4E-259 T 09-03-2017 IPR010225 RNA helicase, ATP-dependent DEAH box, HrpB-type TK78_RS27660 1bcff882cb4ab0d8110bf2827cf69abe 863 Pfam PF08482 ATP-dependent helicase C-terminal 716 847 3.3E-49 T 09-03-2017 IPR013689 ATP-dependent RNA helicase HrpB, C-terminal TK78_RS27660 1bcff882cb4ab0d8110bf2827cf69abe 863 Gene3D G3DSA:3.40.50.300 221 356 2.3E-11 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27660 1bcff882cb4ab0d8110bf2827cf69abe 863 Gene3D G3DSA:3.40.50.300 9 169 1.1E-51 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03140 61d2febd0dee0b7a27db0287416b6736 666 TIGRFAM TIGR01787 squalene_cyclas: squalene/oxidosqualene cyclases 39 650 4.5E-179 T 09-03-2017 IPR018333 Squalene cyclase GO:0016866 Reactome: R-HSA-191273|Reactome: R-HSA-2426168 TK78_RS03140 61d2febd0dee0b7a27db0287416b6736 666 TIGRFAM TIGR01507 hopene_cyclase: squalene-hopene cyclase 33 652 4.8E-233 T 09-03-2017 IPR006400 Squalene hopene cyclase GO:0016866|GO:0019746 KEGG: 00030+4.2.1.12|KEGG: 00909+4.2.1.129+5.4.99.17|MetaCyc: PWY-6098|MetaCyc: PWY-7072 TK78_RS03140 61d2febd0dee0b7a27db0287416b6736 666 SUPERFAMILY SSF48239 322 652 6.28E-101 T 09-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid TK78_RS03140 61d2febd0dee0b7a27db0287416b6736 666 SUPERFAMILY SSF48239 64 330 1.33E-75 T 09-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid TK78_RS03140 61d2febd0dee0b7a27db0287416b6736 666 Pfam PF13249 Squalene-hopene cyclase N-terminal domain 41 326 6.4E-121 T 09-03-2017 IPR032697 Squalene cyclase, N-terminal Reactome: R-HSA-191273|Reactome: R-HSA-2426168 TK78_RS03140 61d2febd0dee0b7a27db0287416b6736 666 Gene3D G3DSA:1.50.10.20 63 320 9.2E-69 T 09-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid TK78_RS03140 61d2febd0dee0b7a27db0287416b6736 666 Pfam PF13243 Squalene-hopene cyclase C-terminal domain 336 651 6.8E-137 T 09-03-2017 IPR032696 Squalene cyclase, C-terminal Reactome: R-HSA-191273|Reactome: R-HSA-2426168 TK78_RS03140 61d2febd0dee0b7a27db0287416b6736 666 Gene3D G3DSA:1.50.10.20 321 650 1.5E-110 T 09-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid TK78_RS03235 b4c5da0b24f915ff8347528eab1d9c43 145 Pfam PF12833 Helix-turn-helix domain 58 137 6.4E-24 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS03235 b4c5da0b24f915ff8347528eab1d9c43 145 Gene3D G3DSA:1.10.10.60 33 89 2.5E-20 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS03235 b4c5da0b24f915ff8347528eab1d9c43 145 SMART SM00342 52 135 1.1E-25 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS03235 b4c5da0b24f915ff8347528eab1d9c43 145 SUPERFAMILY SSF46689 35 85 9.25E-13 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS03235 b4c5da0b24f915ff8347528eab1d9c43 145 Gene3D G3DSA:1.10.10.60 90 139 5.9E-12 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS03235 b4c5da0b24f915ff8347528eab1d9c43 145 SUPERFAMILY SSF46689 88 139 5.82E-10 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS10665 fb136cc23f5474ecf7287fdd319774b0 321 Pfam PF00561 alpha/beta hydrolase fold 57 302 1.3E-22 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS10665 fb136cc23f5474ecf7287fdd319774b0 321 Gene3D G3DSA:3.40.50.1820 29 316 5.5E-53 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS10665 fb136cc23f5474ecf7287fdd319774b0 321 SUPERFAMILY SSF53474 32 313 2.77E-51 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS09075 bffe92712fc975e217930aa25a4c6cb0 410 SMART SM00825 Beta-ketoacyl synthase 5 398 9.5E-15 T 09-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TK78_RS09075 bffe92712fc975e217930aa25a4c6cb0 410 Gene3D G3DSA:3.40.47.10 3 257 3.2E-59 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS09075 bffe92712fc975e217930aa25a4c6cb0 410 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 3 245 7.2E-50 T 09-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal TK78_RS09075 bffe92712fc975e217930aa25a4c6cb0 410 SUPERFAMILY SSF53901 3 252 3.02E-58 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS09075 bffe92712fc975e217930aa25a4c6cb0 410 SUPERFAMILY SSF53901 213 404 1.41E-58 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS09075 bffe92712fc975e217930aa25a4c6cb0 410 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 254 364 7.3E-29 T 09-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal TK78_RS09075 bffe92712fc975e217930aa25a4c6cb0 410 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 154 170 - T 09-03-2017 IPR018201 Beta-ketoacyl synthase, active site TK78_RS09075 bffe92712fc975e217930aa25a4c6cb0 410 Gene3D G3DSA:3.40.47.10 262 404 5.7E-49 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS10715 dcf7a925c2ee330d84081b31e6edb88d 288 Pfam PF02811 PHP domain 4 83 4.2E-8 T 09-03-2017 IPR004013 PHP domain GO:0003824 TK78_RS10715 dcf7a925c2ee330d84081b31e6edb88d 288 SUPERFAMILY SSF89550 2 80 9.42E-44 T 09-03-2017 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 TK78_RS10715 dcf7a925c2ee330d84081b31e6edb88d 288 SUPERFAMILY SSF89550 163 253 9.42E-44 T 09-03-2017 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 TK78_RS10715 dcf7a925c2ee330d84081b31e6edb88d 288 Gene3D G3DSA:3.20.20.140 155 259 9.5E-38 T 09-03-2017 TK78_RS10715 dcf7a925c2ee330d84081b31e6edb88d 288 Gene3D G3DSA:3.20.20.140 2 85 9.5E-38 T 09-03-2017 TK78_RS10715 dcf7a925c2ee330d84081b31e6edb88d 288 SMART SM00481 3 67 4.7E-12 T 09-03-2017 IPR003141 Polymerase/histidinol phosphatase, N-terminal GO:0003677|GO:0003887|GO:0006260 TK78_RS34550 89395fc21b8475ae6c0010301bce6c98 402 Gene3D G3DSA:3.40.50.720 1 170 7.1E-21 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS34550 89395fc21b8475ae6c0010301bce6c98 402 Pfam PF16653 Saccharopine dehydrogenase C-terminal domain 146 394 1.0E-17 T 09-03-2017 IPR032095 Saccharopine dehydrogenase, C-terminal Reactome: R-HSA-71064 TK78_RS34550 89395fc21b8475ae6c0010301bce6c98 402 Pfam PF03435 Saccharopine dehydrogenase NADP binding domain 3 141 6.7E-21 T 09-03-2017 IPR005097 Saccharopine dehydrogenase, NADP binding domain GO:0016491|GO:0055114 TK78_RS34550 89395fc21b8475ae6c0010301bce6c98 402 SUPERFAMILY SSF51735 1 171 3.9E-19 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS11155 be352e8f014dd480d6cab1a46f44a2d8 174 Pfam PF01047 MarR family 44 100 1.9E-13 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS11155 be352e8f014dd480d6cab1a46f44a2d8 174 SMART SM00347 36 136 1.3E-18 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS11155 be352e8f014dd480d6cab1a46f44a2d8 174 Gene3D G3DSA:1.10.10.10 7 148 3.5E-31 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS11155 be352e8f014dd480d6cab1a46f44a2d8 174 SUPERFAMILY SSF46785 11 149 5.77E-27 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS13445 35681349ea8274b66c776f1593a314ae 654 Gene3D G3DSA:3.40.920.10 47 246 1.3E-23 T 09-03-2017 IPR019752 Pyruvate/ketoisovalerate oxidoreductase, catalytic domain GO:0016903|GO:0055114 TK78_RS13445 35681349ea8274b66c776f1593a314ae 654 Pfam PF17147 Pyruvate:ferredoxin oxidoreductase core domain II 553 624 5.9E-8 T 09-03-2017 IPR033412 Pyruvate:ferredoxin oxidoreductase, core domain II TK78_RS13445 35681349ea8274b66c776f1593a314ae 654 Pfam PF01558 Pyruvate ferredoxin/flavodoxin oxidoreductase 55 243 1.1E-25 T 09-03-2017 IPR019752 Pyruvate/ketoisovalerate oxidoreductase, catalytic domain GO:0016903|GO:0055114 TK78_RS13445 35681349ea8274b66c776f1593a314ae 654 Gene3D G3DSA:3.40.50.970 267 461 8.9E-72 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS13445 35681349ea8274b66c776f1593a314ae 654 Gene3D G3DSA:3.40.50.920 550 651 3.1E-11 T 09-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 TK78_RS13445 35681349ea8274b66c776f1593a314ae 654 SUPERFAMILY SSF52518 269 537 1.42E-59 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS13445 35681349ea8274b66c776f1593a314ae 654 SUPERFAMILY SSF52922 551 652 7.07E-15 T 09-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 TK78_RS13445 35681349ea8274b66c776f1593a314ae 654 SUPERFAMILY SSF53323 49 269 3.01E-17 T 09-03-2017 IPR002869 Pyruvate-flavodoxin oxidoreductase, central domain GO:0016491|GO:0055114 TK78_RS13445 35681349ea8274b66c776f1593a314ae 654 Pfam PF01855 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg 298 512 6.4E-51 T 09-03-2017 IPR002880 Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal GO:0016491|GO:0055114 TK78_RS13445 35681349ea8274b66c776f1593a314ae 654 TIGRFAM TIGR03710 OAFO_sf: 2-oxoacid:acceptor oxidoreductase, alpha subunit 47 647 7.9E-199 T 09-03-2017 IPR022367 2-oxoacid:acceptor oxidoreductase, alpha subunit KEGG: 00020+1.2.7.3|KEGG: 00720+1.2.7.3|MetaCyc: PWY-5392|MetaCyc: PWY-6969 TK78_RS31775 5b931420cecee80c3546be8b7d8e6b9e 984 Pfam PF13534 4Fe-4S dicluster domain 573 642 1.1E-7 T 09-03-2017 TK78_RS31775 5b931420cecee80c3546be8b7d8e6b9e 984 SUPERFAMILY SSF46548 537 652 8.89E-15 T 09-03-2017 IPR009051 Alpha-helical ferredoxin GO:0051536 TK78_RS31775 5b931420cecee80c3546be8b7d8e6b9e 984 Gene3D G3DSA:1.10.45.10 510 536 7.7E-5 T 09-03-2017 IPR016171 Vanillyl-alcohol oxidase, C-terminal subdomain 2 TK78_RS31775 5b931420cecee80c3546be8b7d8e6b9e 984 SUPERFAMILY SSF56176 35 293 4.05E-53 T 09-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 TK78_RS31775 5b931420cecee80c3546be8b7d8e6b9e 984 Gene3D G3DSA:1.10.1060.10 537 653 1.1E-15 T 09-03-2017 TK78_RS31775 5b931420cecee80c3546be8b7d8e6b9e 984 Pfam PF01565 FAD binding domain 70 206 5.6E-30 T 09-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 TK78_RS31775 5b931420cecee80c3546be8b7d8e6b9e 984 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 573 584 - T 09-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TK78_RS31775 5b931420cecee80c3546be8b7d8e6b9e 984 Gene3D G3DSA:3.30.465.10 127 293 3.3E-17 T 09-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 TK78_RS31775 5b931420cecee80c3546be8b7d8e6b9e 984 Pfam PF02913 FAD linked oxidases, C-terminal domain 296 546 2.9E-52 T 09-03-2017 IPR004113 FAD-linked oxidase, C-terminal GO:0003824|GO:0050660 TK78_RS31775 5b931420cecee80c3546be8b7d8e6b9e 984 Gene3D G3DSA:3.30.43.10 35 120 1.1E-15 T 09-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 TK78_RS31775 5b931420cecee80c3546be8b7d8e6b9e 984 SUPERFAMILY SSF55103 270 550 5.4E-44 T 09-03-2017 IPR016164 FAD-linked oxidase-like, C-terminal GO:0003824|GO:0050660 TK78_RS20160 00c1ef5ce8190d926556975795c67052 297 Gene3D G3DSA:1.10.3720.10 24 293 2.0E-32 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS20160 00c1ef5ce8190d926556975795c67052 297 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 112 285 1.3E-6 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS20160 00c1ef5ce8190d926556975795c67052 297 SUPERFAMILY SSF161098 20 286 5.98E-33 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS31210 58f38ae3a18f8c491bfaf30eb31e2f10 227 SUPERFAMILY SSF52141 6 222 3.18E-88 T 09-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 TK78_RS31210 58f38ae3a18f8c491bfaf30eb31e2f10 227 ProSitePatterns PS00130 Uracil-DNA glycosylase signature. 60 69 - T 09-03-2017 IPR018085 Uracil-DNA glycosylase, active site GO:0006281|GO:0016799 Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 TK78_RS31210 58f38ae3a18f8c491bfaf30eb31e2f10 227 TIGRFAM TIGR00628 ung: uracil-DNA glycosylase 9 214 3.6E-78 T 09-03-2017 IPR002043 Uracil-DNA glycosylase GO:0004844|GO:0006281|GO:0006284 Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 TK78_RS31210 58f38ae3a18f8c491bfaf30eb31e2f10 227 Gene3D G3DSA:3.40.470.10 4 223 5.6E-94 T 09-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 TK78_RS31210 58f38ae3a18f8c491bfaf30eb31e2f10 227 Hamap MF_00148 Uracil-DNA glycosylase [ung]. 8 222 40.108 T 09-03-2017 IPR002043 Uracil-DNA glycosylase GO:0004844|GO:0006281|GO:0006284 Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 TK78_RS31210 58f38ae3a18f8c491bfaf30eb31e2f10 227 Pfam PF03167 Uracil DNA glycosylase superfamily 56 208 5.3E-23 T 09-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 TK78_RS31210 58f38ae3a18f8c491bfaf30eb31e2f10 227 SMART SM00986 52 211 1.8E-32 T 09-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 TK78_RS31210 58f38ae3a18f8c491bfaf30eb31e2f10 227 SMART SM00987 52 211 1.8E-32 T 09-03-2017 TK78_RS12255 6364a727d643f533e85530a98b0c1ec1 153 SUPERFAMILY SSF46785 11 146 1.72E-15 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS12255 6364a727d643f533e85530a98b0c1ec1 153 Pfam PF13463 Winged helix DNA-binding domain 39 105 1.7E-10 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS12255 6364a727d643f533e85530a98b0c1ec1 153 Gene3D G3DSA:1.10.10.10 12 147 6.6E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS27545 37165d730813a0948867ca040356c730 123 SMART SM00418 11 89 4.2E-27 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS27545 37165d730813a0948867ca040356c730 123 SUPERFAMILY SSF46785 6 88 1.02E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS27545 37165d730813a0948867ca040356c730 123 Gene3D G3DSA:1.10.10.10 9 91 8.5E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS27545 37165d730813a0948867ca040356c730 123 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 60 75 6.5E-11 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS27545 37165d730813a0948867ca040356c730 123 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 45 60 6.5E-11 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS27545 37165d730813a0948867ca040356c730 123 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 13 28 6.5E-11 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS27545 37165d730813a0948867ca040356c730 123 Pfam PF12840 Helix-turn-helix domain 11 68 1.8E-11 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS07235 9649fd068507a2e43bb8a28051f251d3 224 SUPERFAMILY SSF52172 3 126 8.97E-33 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS07235 9649fd068507a2e43bb8a28051f251d3 224 Gene3D G3DSA:1.10.10.10 166 204 5.1E-8 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS07235 9649fd068507a2e43bb8a28051f251d3 224 Pfam PF08279 HTH domain 166 204 1.4E-7 T 09-03-2017 IPR013196 Helix-turn-helix, type 11 TK78_RS07235 9649fd068507a2e43bb8a28051f251d3 224 SUPERFAMILY SSF46785 167 220 1.1E-7 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS07235 9649fd068507a2e43bb8a28051f251d3 224 Gene3D G3DSA:3.40.50.2300 2 125 6.7E-30 T 09-03-2017 TK78_RS07235 9649fd068507a2e43bb8a28051f251d3 224 SMART SM00448 2 115 1.6E-24 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS07235 9649fd068507a2e43bb8a28051f251d3 224 Pfam PF00072 Response regulator receiver domain 4 115 3.4E-23 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS07235 9649fd068507a2e43bb8a28051f251d3 224 PIRSF PIRSF006171 1 224 3.3E-78 T 09-03-2017 IPR024187 Signal transduction response regulator, citrate/malate metabolism GO:0001071|GO:0003677|GO:0005737|GO:0009605 TK78_RS18170 03646b7f14d02a738dabf2ddd837fbcb 764 SMART SM00382 37 181 1.7E-10 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS18170 03646b7f14d02a738dabf2ddd837fbcb 764 TIGRFAM TIGR02397 dnaX_nterm: DNA polymerase III, subunit gamma and tau 5 363 1.6E-115 T 09-03-2017 IPR012763 DNA polymerase III, subunit gamma/ tau GO:0003887|GO:0005524|GO:0006260|GO:0009360 TK78_RS18170 03646b7f14d02a738dabf2ddd837fbcb 764 Pfam PF13177 DNA polymerase III, delta subunit 20 178 3.8E-38 T 09-03-2017 TK78_RS18170 03646b7f14d02a738dabf2ddd837fbcb 764 Pfam PF12169 DNA polymerase III subunits gamma and tau domain III 236 364 3.4E-13 T 09-03-2017 IPR022754 DNA polymerase III, gamma subunit, domain III GO:0003887 TK78_RS18170 03646b7f14d02a738dabf2ddd837fbcb 764 Gene3D G3DSA:3.40.50.300 15 167 6.7E-60 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18170 03646b7f14d02a738dabf2ddd837fbcb 764 SUPERFAMILY SSF48019 247 365 1.02E-21 T 09-03-2017 IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal GO:0003677|GO:0006260 Reactome: R-HSA-110312|Reactome: R-HSA-110314|Reactome: R-HSA-110320|Reactome: R-HSA-174411|Reactome: R-HSA-5651801|Reactome: R-HSA-5655862|Reactome: R-HSA-5656121|Reactome: R-HSA-5656169|Reactome: R-HSA-5685942|Reactome: R-HSA-5696397|Reactome: R-HSA-5696400|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210|Reactome: R-HSA-69091 TK78_RS18170 03646b7f14d02a738dabf2ddd837fbcb 764 SUPERFAMILY SSF52540 32 222 3.41E-51 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18170 03646b7f14d02a738dabf2ddd837fbcb 764 Gene3D G3DSA:1.10.8.60 168 245 8.7E-20 T 09-03-2017 TK78_RS18170 03646b7f14d02a738dabf2ddd837fbcb 764 Gene3D G3DSA:1.20.272.10 246 364 1.1E-14 T 09-03-2017 TK78_RS16585 c0f3480d7f5596907487f2a6e81ebc95 295 Gene3D G3DSA:1.10.10.10 145 198 5.4E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS16585 c0f3480d7f5596907487f2a6e81ebc95 295 ProSitePatterns PS00715 Sigma-70 factors family signature 1. 99 112 - T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16585 c0f3480d7f5596907487f2a6e81ebc95 295 Pfam PF04539 Sigma-70 region 3 154 217 6.3E-15 T 09-03-2017 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16585 c0f3480d7f5596907487f2a6e81ebc95 295 Pfam PF04545 Sigma-70, region 4 241 288 1.8E-15 T 09-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16585 c0f3480d7f5596907487f2a6e81ebc95 295 SUPERFAMILY SSF88946 44 145 6.67E-31 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16585 c0f3480d7f5596907487f2a6e81ebc95 295 Pfam PF04542 Sigma-70 region 2 75 144 8.3E-19 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16585 c0f3480d7f5596907487f2a6e81ebc95 295 SUPERFAMILY SSF88659 226 290 1.38E-14 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16585 c0f3480d7f5596907487f2a6e81ebc95 295 Gene3D G3DSA:1.10.10.10 232 289 7.9E-10 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS16585 c0f3480d7f5596907487f2a6e81ebc95 295 Gene3D G3DSA:1.10.601.10 59 144 5.2E-26 T 09-03-2017 TK78_RS16585 c0f3480d7f5596907487f2a6e81ebc95 295 PRINTS PR00046 Major sigma-70 factor signature 244 256 8.4E-8 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16585 c0f3480d7f5596907487f2a6e81ebc95 295 PRINTS PR00046 Major sigma-70 factor signature 99 112 8.4E-8 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16585 c0f3480d7f5596907487f2a6e81ebc95 295 PRINTS PR00046 Major sigma-70 factor signature 261 276 8.4E-8 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16585 c0f3480d7f5596907487f2a6e81ebc95 295 TIGRFAM TIGR02980 SigBFG: RNA polymerase sigma-70 factor, sigma-B/F/G subfamily 69 290 1.6E-88 T 09-03-2017 IPR014322 RNA polymerase sigma-B/F/G type GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16585 c0f3480d7f5596907487f2a6e81ebc95 295 SUPERFAMILY SSF88659 148 221 3.88E-13 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16585 c0f3480d7f5596907487f2a6e81ebc95 295 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 72 289 2.7E-33 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS05565 af25c0887e4c29164bcfcad763aba44e 272 Pfam PF13411 MerR HTH family regulatory protein 4 69 3.0E-11 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS05565 af25c0887e4c29164bcfcad763aba44e 272 SUPERFAMILY SSF46955 4 105 6.96E-21 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS05565 af25c0887e4c29164bcfcad763aba44e 272 Gene3D G3DSA:1.10.1660.10 4 105 9.7E-24 T 09-03-2017 TK78_RS05565 af25c0887e4c29164bcfcad763aba44e 272 SMART SM00422 3 72 8.7E-15 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS28640 2f7ae15b1b31d86910a9ac69965ff1e5 713 Pfam PF13424 Tetratricopeptide repeat 506 575 3.5E-8 T 09-03-2017 TK78_RS28640 2f7ae15b1b31d86910a9ac69965ff1e5 713 SUPERFAMILY SSF52540 28 313 8.84E-19 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28640 2f7ae15b1b31d86910a9ac69965ff1e5 713 SUPERFAMILY SSF48452 501 617 8.34E-13 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS28640 2f7ae15b1b31d86910a9ac69965ff1e5 713 Pfam PF00931 NB-ARC domain 152 265 6.1E-6 T 09-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 TK78_RS28640 2f7ae15b1b31d86910a9ac69965ff1e5 713 SMART SM00028 547 580 65.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS28640 2f7ae15b1b31d86910a9ac69965ff1e5 713 SMART SM00028 507 540 170.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS28640 2f7ae15b1b31d86910a9ac69965ff1e5 713 SMART SM00028 627 660 34.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS28640 2f7ae15b1b31d86910a9ac69965ff1e5 713 SMART SM00028 587 620 60.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS28640 2f7ae15b1b31d86910a9ac69965ff1e5 713 Gene3D G3DSA:3.40.50.300 141 181 3.1E-5 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28640 2f7ae15b1b31d86910a9ac69965ff1e5 713 Gene3D G3DSA:3.40.50.300 31 88 3.1E-5 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28640 2f7ae15b1b31d86910a9ac69965ff1e5 713 SUPERFAMILY SSF48452 584 697 1.39E-11 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS28640 2f7ae15b1b31d86910a9ac69965ff1e5 713 SMART SM00382 60 235 0.003 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS28640 2f7ae15b1b31d86910a9ac69965ff1e5 713 Gene3D G3DSA:1.25.40.10 494 595 9.8E-12 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS28640 2f7ae15b1b31d86910a9ac69965ff1e5 713 Gene3D G3DSA:1.25.40.10 596 687 1.2E-11 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS12080 77cf394eff086d3db98011b38080c5c6 263 Gene3D G3DSA:1.10.1740.10 89 164 4.5E-18 T 09-03-2017 TK78_RS12080 77cf394eff086d3db98011b38080c5c6 263 Gene3D G3DSA:1.10.10.10 185 244 1.3E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS12080 77cf394eff086d3db98011b38080c5c6 263 SUPERFAMILY SSF88946 90 176 1.33E-15 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12080 77cf394eff086d3db98011b38080c5c6 263 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 95 244 1.2E-23 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12080 77cf394eff086d3db98011b38080c5c6 263 SUPERFAMILY SSF88659 183 244 3.18E-16 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12080 77cf394eff086d3db98011b38080c5c6 263 TIGRFAM TIGR02983 SigE-fam_strep: RNA polymerase sigma-70 factor, sigma-E family 90 246 1.7E-61 T 09-03-2017 IPR014325 RNA polymerase sigma-E factor, actinobacteria GO:0016987 TK78_RS12080 77cf394eff086d3db98011b38080c5c6 263 Pfam PF08281 Sigma-70, region 4 191 242 2.2E-14 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12080 77cf394eff086d3db98011b38080c5c6 263 Pfam PF04542 Sigma-70 region 2 101 164 1.3E-11 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS32560 da483bde97f4ce35db93fcab0a62aa3f 301 SUPERFAMILY SSF49899 51 299 4.98E-73 T 09-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain TK78_RS32560 da483bde97f4ce35db93fcab0a62aa3f 301 Pfam PF00722 Glycosyl hydrolases family 16 90 297 2.8E-44 T 09-03-2017 IPR000757 Glycoside hydrolase family 16 GO:0004553|GO:0005975 TK78_RS32560 da483bde97f4ce35db93fcab0a62aa3f 301 Gene3D G3DSA:2.60.120.200 53 299 4.7E-78 T 09-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain TK78_RS04170 e2386b6b82df6c92c8adb953d2af85ab 817 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 60 467 7.2E-80 T 09-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 TK78_RS04170 e2386b6b82df6c92c8adb953d2af85ab 817 Gene3D G3DSA:2.60.40.10 739 791 3.8E-11 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS04170 e2386b6b82df6c92c8adb953d2af85ab 817 SUPERFAMILY SSF103473 45 241 6.67E-72 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS04170 e2386b6b82df6c92c8adb953d2af85ab 817 SUPERFAMILY SSF103473 294 466 6.67E-72 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS04170 e2386b6b82df6c92c8adb953d2af85ab 817 SUPERFAMILY SSF103473 509 535 6.67E-72 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS04170 e2386b6b82df6c92c8adb953d2af85ab 817 PRINTS PR01035 Tetracycline resistance protein signature 73 89 1.4E-6 T 09-03-2017 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 TK78_RS04170 e2386b6b82df6c92c8adb953d2af85ab 817 PRINTS PR01035 Tetracycline resistance protein signature 351 371 1.4E-6 T 09-03-2017 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 TK78_RS04170 e2386b6b82df6c92c8adb953d2af85ab 817 PRINTS PR01035 Tetracycline resistance protein signature 184 206 1.4E-6 T 09-03-2017 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 TK78_RS04170 e2386b6b82df6c92c8adb953d2af85ab 817 Gene3D G3DSA:2.60.40.1120 653 733 1.1E-12 T 09-03-2017 IPR014766 Carboxypeptidase, regulatory domain TK78_RS04170 e2386b6b82df6c92c8adb953d2af85ab 817 Gene3D G3DSA:2.60.40.1120 570 647 2.5E-8 T 09-03-2017 IPR014766 Carboxypeptidase, regulatory domain TK78_RS04170 e2386b6b82df6c92c8adb953d2af85ab 817 Pfam PF07690 Major Facilitator Superfamily 64 457 4.9E-55 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS04170 e2386b6b82df6c92c8adb953d2af85ab 817 SUPERFAMILY SSF49452 647 731 2.94E-12 T 09-03-2017 IPR013784 Carbohydrate-binding-like fold GO:0030246 TK78_RS04170 e2386b6b82df6c92c8adb953d2af85ab 817 Pfam PF13620 Carboxypeptidase regulatory-like domain 737 813 3.2E-12 T 09-03-2017 TK78_RS04170 e2386b6b82df6c92c8adb953d2af85ab 817 Pfam PF13620 Carboxypeptidase regulatory-like domain 653 731 1.9E-15 T 09-03-2017 TK78_RS04170 e2386b6b82df6c92c8adb953d2af85ab 817 Pfam PF13620 Carboxypeptidase regulatory-like domain 570 647 2.9E-10 T 09-03-2017 TK78_RS04170 e2386b6b82df6c92c8adb953d2af85ab 817 Gene3D G3DSA:1.20.1250.20 315 476 4.6E-22 T 09-03-2017 TK78_RS04170 e2386b6b82df6c92c8adb953d2af85ab 817 Gene3D G3DSA:1.20.1250.20 515 539 4.6E-22 T 09-03-2017 TK78_RS04170 e2386b6b82df6c92c8adb953d2af85ab 817 Gene3D G3DSA:1.20.1250.20 61 238 1.4E-32 T 09-03-2017 TK78_RS04170 e2386b6b82df6c92c8adb953d2af85ab 817 SUPERFAMILY SSF49478 737 805 3.92E-11 T 09-03-2017 TK78_RS04170 e2386b6b82df6c92c8adb953d2af85ab 817 SUPERFAMILY SSF49464 570 647 3.57E-9 T 09-03-2017 IPR008969 Carboxypeptidase-like, regulatory domain TK78_RS07665 6a1060fb749725abf2a49a2035cf665f 250 SUPERFAMILY SSF51735 4 135 2.75E-33 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07665 6a1060fb749725abf2a49a2035cf665f 250 Pfam PF05173 Dihydrodipicolinate reductase, C-terminus 111 247 1.4E-27 T 09-03-2017 IPR022663 Dihydrodipicolinate reductase, C-terminal GO:0008839|GO:0009089|GO:0055114 KEGG: 00261+1.17.1.8|KEGG: 00300+1.17.1.8|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS07665 6a1060fb749725abf2a49a2035cf665f 250 TIGRFAM TIGR00036 dapB: 4-hydroxy-tetrahydrodipicolinate reductase 43 248 5.8E-51 T 09-03-2017 IPR023940 Dihydrodipicolinate reductase GO:0008839|GO:0009089|GO:0055114 KEGG: 00261+1.17.1.8|KEGG: 00300+1.17.1.8|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS07665 6a1060fb749725abf2a49a2035cf665f 250 SUPERFAMILY SSF55347 109 217 7.85E-39 T 09-03-2017 TK78_RS07665 6a1060fb749725abf2a49a2035cf665f 250 Hamap MF_00102 4-hydroxy-tetrahydrodipicolinate reductase [dapB]. 4 248 29.024 T 09-03-2017 IPR023940 Dihydrodipicolinate reductase GO:0008839|GO:0009089|GO:0055114 KEGG: 00261+1.17.1.8|KEGG: 00300+1.17.1.8|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS07665 6a1060fb749725abf2a49a2035cf665f 250 PIRSF PIRSF000161 2 250 4.0E-60 T 09-03-2017 IPR023940 Dihydrodipicolinate reductase GO:0008839|GO:0009089|GO:0055114 KEGG: 00261+1.17.1.8|KEGG: 00300+1.17.1.8|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS07665 6a1060fb749725abf2a49a2035cf665f 250 ProSitePatterns PS01298 Dihydrodipicolinate reductase signature. 130 147 - T 09-03-2017 IPR022664 Dihydrodipicolinate reductase, conserved site GO:0008839|GO:0009089|GO:0055114 KEGG: 00261+1.17.1.8|KEGG: 00300+1.17.1.8|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS07665 6a1060fb749725abf2a49a2035cf665f 250 Gene3D G3DSA:3.40.50.720 3 143 3.1E-50 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07665 6a1060fb749725abf2a49a2035cf665f 250 Pfam PF01113 Dihydrodipicolinate reductase, N-terminus 5 108 1.2E-22 T 09-03-2017 IPR000846 Dihydrodipicolinate reductase, N-terminal GO:0008839|GO:0009089|GO:0055114 KEGG: 00261+1.17.1.8|KEGG: 00300+1.17.1.8|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS14235 8f51a1b472b4114f7c528bfc1dea2e99 163 Pfam PF04978 Protein of unknown function (DUF664) 2 148 2.4E-38 T 09-03-2017 IPR007061 Protein of unknown function DUF664 TK78_RS14235 8f51a1b472b4114f7c528bfc1dea2e99 163 SUPERFAMILY SSF109854 2 147 4.88E-29 T 09-03-2017 TK78_RS14235 8f51a1b472b4114f7c528bfc1dea2e99 163 Gene3D G3DSA:1.20.120.450 1 149 1.4E-31 T 09-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase TK78_RS31660 91bd5a854aea7277a1c064948da98f86 341 TIGRFAM TIGR02483 PFK_mixed: phosphofructokinase 2 323 2.0E-147 T 09-03-2017 IPR012829 Phosphofructokinase, mixed-substrate PFK group III GO:0006096|GO:0047334 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385 TK78_RS31660 91bd5a854aea7277a1c064948da98f86 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 176 193 7.2E-76 T 09-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TK78_RS31660 91bd5a854aea7277a1c064948da98f86 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 212 224 7.2E-76 T 09-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TK78_RS31660 91bd5a854aea7277a1c064948da98f86 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 93 109 7.2E-76 T 09-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TK78_RS31660 91bd5a854aea7277a1c064948da98f86 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 120 137 7.2E-76 T 09-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TK78_RS31660 91bd5a854aea7277a1c064948da98f86 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 138 156 7.2E-76 T 09-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TK78_RS31660 91bd5a854aea7277a1c064948da98f86 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 158 174 7.2E-76 T 09-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TK78_RS31660 91bd5a854aea7277a1c064948da98f86 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 262 284 7.2E-76 T 09-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TK78_RS31660 91bd5a854aea7277a1c064948da98f86 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 5 24 7.2E-76 T 09-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TK78_RS31660 91bd5a854aea7277a1c064948da98f86 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 31 44 7.2E-76 T 09-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TK78_RS31660 91bd5a854aea7277a1c064948da98f86 341 SUPERFAMILY SSF53784 1 333 2.75E-121 T 09-03-2017 IPR000023 Phosphofructokinase domain GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TK78_RS31660 91bd5a854aea7277a1c064948da98f86 341 Hamap MF_01976 Pyrophosphate--fructose 6-phosphate 1-phosphotransferase [pfp]. 1 341 43.146 T 09-03-2017 IPR012829 Phosphofructokinase, mixed-substrate PFK group III GO:0006096|GO:0047334 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385 TK78_RS31660 91bd5a854aea7277a1c064948da98f86 341 Pfam PF00365 Phosphofructokinase 2 297 5.4E-103 T 09-03-2017 IPR000023 Phosphofructokinase domain GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TK78_RS31660 91bd5a854aea7277a1c064948da98f86 341 ProSitePatterns PS00433 Phosphofructokinase signature. 266 284 - T 09-03-2017 IPR015912 Phosphofructokinase, conserved site GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TK78_RS31660 91bd5a854aea7277a1c064948da98f86 341 Gene3D G3DSA:3.40.50.450 1 213 2.8E-73 T 09-03-2017 TK78_RS31660 91bd5a854aea7277a1c064948da98f86 341 PIRSF PIRSF000532 1 339 1.6E-116 T 09-03-2017 IPR012003 ATP-dependent 6-phosphofructokinase, prokaryotic-type GO:0005524|GO:0006002|GO:0006096|GO:0008443 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385 TK78_RS11255 b26bfa7f4c6a3dc5d4b04116db153f2e 134 Pfam PF00293 NUDIX domain 17 112 9.2E-9 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS11255 b26bfa7f4c6a3dc5d4b04116db153f2e 134 Gene3D G3DSA:3.90.79.10 9 127 1.2E-14 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS11255 b26bfa7f4c6a3dc5d4b04116db153f2e 134 SUPERFAMILY SSF55811 8 123 3.38E-17 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS11255 b26bfa7f4c6a3dc5d4b04116db153f2e 134 ProSitePatterns PS00893 Nudix box signature. 35 56 - T 09-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 TK78_RS06630 b43bff9da11f188bc861e501a87bacf6 386 SUPERFAMILY SSF54373 215 317 2.49E-12 T 09-03-2017 TK78_RS06630 b43bff9da11f188bc861e501a87bacf6 386 Gene3D G3DSA:3.50.50.60 317 363 3.5E-53 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS06630 b43bff9da11f188bc861e501a87bacf6 386 Gene3D G3DSA:3.50.50.60 1 78 3.5E-53 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS06630 b43bff9da11f188bc861e501a87bacf6 386 Gene3D G3DSA:3.50.50.60 132 200 3.5E-53 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS06630 b43bff9da11f188bc861e501a87bacf6 386 Pfam PF01266 FAD dependent oxidoreductase 3 355 2.2E-63 T 09-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 TK78_RS06630 b43bff9da11f188bc861e501a87bacf6 386 SUPERFAMILY SSF51905 317 370 3.56E-52 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS06630 b43bff9da11f188bc861e501a87bacf6 386 SUPERFAMILY SSF51905 1 215 3.56E-52 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS06630 b43bff9da11f188bc861e501a87bacf6 386 Gene3D G3DSA:3.30.9.10 201 315 3.9E-10 T 09-03-2017 TK78_RS28610 7867f19372a760319dc7c9b5716bf972 541 Pfam PF13556 PucR C-terminal helix-turn-helix domain 478 536 1.8E-20 T 09-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain TK78_RS28610 7867f19372a760319dc7c9b5716bf972 541 Gene3D G3DSA:1.10.10.60 482 514 1.9E-6 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS28610 7867f19372a760319dc7c9b5716bf972 541 Pfam PF07905 Purine catabolism regulatory protein-like family 12 132 2.5E-38 T 09-03-2017 IPR012914 Purine catabolism PurC-like domain TK78_RS13285 e046b2c4b2fa5754c119b89de8e9da5a 196 SUPERFAMILY SSF48498 74 194 3.78E-5 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS13285 e046b2c4b2fa5754c119b89de8e9da5a 196 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 10 23 1.6E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS13285 e046b2c4b2fa5754c119b89de8e9da5a 196 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 31 54 1.6E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS13285 e046b2c4b2fa5754c119b89de8e9da5a 196 SUPERFAMILY SSF46689 5 79 1.25E-16 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS13285 e046b2c4b2fa5754c119b89de8e9da5a 196 Pfam PF00440 Bacterial regulatory proteins, tetR family 10 54 4.5E-15 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS13285 e046b2c4b2fa5754c119b89de8e9da5a 196 Gene3D G3DSA:1.10.357.10 7 195 3.9E-32 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS26630 1b81f48a3a2801fff55dbb159823d38e 587 Gene3D G3DSA:4.10.320.10 277 327 4.9E-19 T 09-03-2017 IPR004167 E3-binding domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 TK78_RS26630 1b81f48a3a2801fff55dbb159823d38e 587 ProSitePatterns PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 147 176 - T 09-03-2017 IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site Reactome: R-HSA-389661 TK78_RS26630 1b81f48a3a2801fff55dbb159823d38e 587 Gene3D G3DSA:3.30.559.10 344 578 8.6E-79 T 09-03-2017 IPR023213 Chloramphenicol acetyltransferase-like domain Reactome: R-HSA-389661 TK78_RS26630 1b81f48a3a2801fff55dbb159823d38e 587 Pfam PF00364 Biotin-requiring enzyme 5 76 1.6E-21 T 09-03-2017 IPR000089 Biotin/lipoyl attachment TK78_RS26630 1b81f48a3a2801fff55dbb159823d38e 587 Pfam PF00364 Biotin-requiring enzyme 124 196 2.2E-20 T 09-03-2017 IPR000089 Biotin/lipoyl attachment TK78_RS26630 1b81f48a3a2801fff55dbb159823d38e 587 Gene3D G3DSA:2.40.50.100 1 96 3.0E-30 T 09-03-2017 TK78_RS26630 1b81f48a3a2801fff55dbb159823d38e 587 Gene3D G3DSA:2.40.50.100 123 216 2.4E-29 T 09-03-2017 TK78_RS26630 1b81f48a3a2801fff55dbb159823d38e 587 Pfam PF02817 e3 binding domain 283 315 1.5E-14 T 09-03-2017 IPR004167 E3-binding domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 TK78_RS26630 1b81f48a3a2801fff55dbb159823d38e 587 SUPERFAMILY SSF51230 2 96 6.02E-27 T 09-03-2017 IPR011053 Single hybrid motif TK78_RS26630 1b81f48a3a2801fff55dbb159823d38e 587 TIGRFAM TIGR02927 SucB_Actino: 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase 1 587 7.1E-222 T 09-03-2017 IPR014276 2-oxoglutarate dehydrogenase, E2 component KEGG: 00010+2.3.1.12|KEGG: 00020+2.3.1.12|KEGG: 00620+2.3.1.12 TK78_RS26630 1b81f48a3a2801fff55dbb159823d38e 587 SUPERFAMILY SSF52777 341 578 1.65E-77 T 09-03-2017 TK78_RS26630 1b81f48a3a2801fff55dbb159823d38e 587 SUPERFAMILY SSF51230 123 216 3.14E-26 T 09-03-2017 IPR011053 Single hybrid motif TK78_RS26630 1b81f48a3a2801fff55dbb159823d38e 587 Pfam PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain) 351 578 3.4E-73 T 09-03-2017 IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 TK78_RS26630 1b81f48a3a2801fff55dbb159823d38e 587 SUPERFAMILY SSF47005 276 319 3.01E-12 T 09-03-2017 IPR004167 E3-binding domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 TK78_RS26630 1b81f48a3a2801fff55dbb159823d38e 587 ProSitePatterns PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 27 56 - T 09-03-2017 IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site Reactome: R-HSA-389661 TK78_RS31605 db7fcb620d57b232aabe88cae17d1d87 206 SUPERFAMILY SSF48498 105 187 6.16E-11 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS31605 db7fcb620d57b232aabe88cae17d1d87 206 Gene3D G3DSA:1.10.357.10 5 191 5.3E-45 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS31605 db7fcb620d57b232aabe88cae17d1d87 206 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 16 29 1.1E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS31605 db7fcb620d57b232aabe88cae17d1d87 206 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 37 60 1.1E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS31605 db7fcb620d57b232aabe88cae17d1d87 206 ProSitePatterns PS01081 TetR-type HTH domain signature. 28 59 - T 09-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site TK78_RS31605 db7fcb620d57b232aabe88cae17d1d87 206 SUPERFAMILY SSF46689 2 77 4.82E-20 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS31605 db7fcb620d57b232aabe88cae17d1d87 206 Pfam PF00440 Bacterial regulatory proteins, tetR family 16 62 3.2E-17 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS11910 0c5c11f6ff8ea181c73e22994662f9d4 150 Gene3D G3DSA:1.10.260.40 38 104 6.1E-14 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS11910 0c5c11f6ff8ea181c73e22994662f9d4 150 SUPERFAMILY SSF47413 32 101 1.78E-12 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS11910 0c5c11f6ff8ea181c73e22994662f9d4 150 Pfam PF13560 Helix-turn-helix domain 39 99 9.7E-12 T 09-03-2017 TK78_RS11910 0c5c11f6ff8ea181c73e22994662f9d4 150 SMART SM00530 41 96 2.3E-10 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS03775 bf05dfb6d2da5a61b6c2396a814b58d4 326 TIGRFAM TIGR03395 sphingomy: sphingomyelin phosphodiesterase 38 323 2.5E-94 T 09-03-2017 IPR017766 Sphingomyelinase C/phospholipase C GO:0005576|GO:0008081 TK78_RS03775 bf05dfb6d2da5a61b6c2396a814b58d4 326 SUPERFAMILY SSF56219 36 322 8.38E-71 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS03775 bf05dfb6d2da5a61b6c2396a814b58d4 326 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 67 318 1.1E-22 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS03775 bf05dfb6d2da5a61b6c2396a814b58d4 326 Gene3D G3DSA:3.60.10.10 32 322 3.6E-10 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS27060 8fb3068e3f5957f987c2bb91583ee3ca 321 SUPERFAMILY SSF81799 120 221 4.19E-32 T 09-03-2017 IPR023397 S-adenosyl-L-methionine-dependent methyltransferase, MraW, recognition domain GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 TK78_RS27060 8fb3068e3f5957f987c2bb91583ee3ca 321 Gene3D G3DSA:1.10.150.170 119 223 7.8E-35 T 09-03-2017 IPR023397 S-adenosyl-L-methionine-dependent methyltransferase, MraW, recognition domain GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 TK78_RS27060 8fb3068e3f5957f987c2bb91583ee3ca 321 SUPERFAMILY SSF53335 6 119 1.04E-38 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS27060 8fb3068e3f5957f987c2bb91583ee3ca 321 SUPERFAMILY SSF53335 221 316 1.04E-38 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS27060 8fb3068e3f5957f987c2bb91583ee3ca 321 Pfam PF01795 MraW methylase family 4 315 1.9E-110 T 09-03-2017 IPR002903 Ribosomal RNA small subunit methyltransferase H GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 TK78_RS27060 8fb3068e3f5957f987c2bb91583ee3ca 321 PIRSF PIRSF004486 1 317 2.2E-97 T 09-03-2017 IPR002903 Ribosomal RNA small subunit methyltransferase H GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 TK78_RS27060 8fb3068e3f5957f987c2bb91583ee3ca 321 TIGRFAM TIGR00006 TIGR00006: 16S rRNA (cytosine(1402)-N(4))-methyltransferase 2 315 1.8E-91 T 09-03-2017 IPR002903 Ribosomal RNA small subunit methyltransferase H GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 TK78_RS27060 8fb3068e3f5957f987c2bb91583ee3ca 321 Hamap MF_01007 Ribosomal RNA small subunit methyltransferase H [rsmH]. 6 316 36.279 T 09-03-2017 IPR002903 Ribosomal RNA small subunit methyltransferase H GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 TK78_RS27060 8fb3068e3f5957f987c2bb91583ee3ca 321 Gene3D G3DSA:3.40.50.150 224 318 1.9E-47 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS27060 8fb3068e3f5957f987c2bb91583ee3ca 321 Gene3D G3DSA:3.40.50.150 6 116 1.9E-47 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS14505 284532dfcfddaf50a44f801405325364 205 Pfam PF00440 Bacterial regulatory proteins, tetR family 21 63 8.2E-14 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS14505 284532dfcfddaf50a44f801405325364 205 Gene3D G3DSA:1.10.10.60 4 71 3.3E-23 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS14505 284532dfcfddaf50a44f801405325364 205 SUPERFAMILY SSF46689 4 81 1.54E-17 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS14505 284532dfcfddaf50a44f801405325364 205 SUPERFAMILY SSF48498 83 194 3.06E-19 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS14505 284532dfcfddaf50a44f801405325364 205 Gene3D G3DSA:1.10.357.10 72 197 5.5E-27 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS31320 3f0e1d9687a43dc1abbf7433e57a6219 391 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 14 147 1.3E-12 T 09-03-2017 IPR005225 Small GTP-binding protein domain GO:0005525 TK78_RS31320 3f0e1d9687a43dc1abbf7433e57a6219 391 Hamap MF_00118_B Elongation factor Tu [tuf]. 1 391 52.716 T 09-03-2017 IPR004541 Translation elongation factor EFTu/EF1A, bacterial/organelle GO:0003746|GO:0005525|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 TK78_RS31320 3f0e1d9687a43dc1abbf7433e57a6219 391 Gene3D G3DSA:2.40.30.10 299 390 1.5E-32 T 09-03-2017 TK78_RS31320 3f0e1d9687a43dc1abbf7433e57a6219 391 SUPERFAMILY SSF50447 206 300 5.11E-26 T 09-03-2017 IPR009000 Translation protein, beta-barrel domain TK78_RS31320 3f0e1d9687a43dc1abbf7433e57a6219 391 Pfam PF03143 Elongation factor Tu C-terminal domain 297 390 1.1E-22 T 09-03-2017 IPR004160 Translation elongation factor EFTu/EF1A, C-terminal TK78_RS31320 3f0e1d9687a43dc1abbf7433e57a6219 391 ProSitePatterns PS00301 Translational (tr)-type guanine nucleotide-binding (G) domain signature. 53 68 - T 09-03-2017 IPR031157 Tr-type G domain, conserved site TK78_RS31320 3f0e1d9687a43dc1abbf7433e57a6219 391 Gene3D G3DSA:3.40.50.300 8 212 2.4E-60 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31320 3f0e1d9687a43dc1abbf7433e57a6219 391 TIGRFAM TIGR00485 EF-Tu: translation elongation factor Tu 1 390 3.2E-171 T 09-03-2017 IPR004541 Translation elongation factor EFTu/EF1A, bacterial/organelle GO:0003746|GO:0005525|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 TK78_RS31320 3f0e1d9687a43dc1abbf7433e57a6219 391 SUPERFAMILY SSF52540 8 227 7.43E-54 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31320 3f0e1d9687a43dc1abbf7433e57a6219 391 Gene3D G3DSA:2.40.30.10 213 297 1.3E-29 T 09-03-2017 TK78_RS31320 3f0e1d9687a43dc1abbf7433e57a6219 391 Pfam PF00009 Elongation factor Tu GTP binding domain 10 202 3.1E-53 T 09-03-2017 TK78_RS31320 3f0e1d9687a43dc1abbf7433e57a6219 391 PRINTS PR00315 GTP-binding elongation factor signature 80 90 1.5E-23 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS31320 3f0e1d9687a43dc1abbf7433e57a6219 391 PRINTS PR00315 GTP-binding elongation factor signature 96 107 1.5E-23 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS31320 3f0e1d9687a43dc1abbf7433e57a6219 391 PRINTS PR00315 GTP-binding elongation factor signature 60 68 1.5E-23 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS31320 3f0e1d9687a43dc1abbf7433e57a6219 391 PRINTS PR00315 GTP-binding elongation factor signature 14 27 1.5E-23 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS31320 3f0e1d9687a43dc1abbf7433e57a6219 391 PRINTS PR00315 GTP-binding elongation factor signature 133 142 1.5E-23 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS31320 3f0e1d9687a43dc1abbf7433e57a6219 391 Pfam PF03144 Elongation factor Tu domain 2 226 292 1.0E-12 T 09-03-2017 IPR004161 Translation elongation factor EFTu-like, domain 2 GO:0005525 TK78_RS31320 3f0e1d9687a43dc1abbf7433e57a6219 391 SUPERFAMILY SSF50465 302 390 4.32E-26 T 09-03-2017 IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal TK78_RS33245 f98c6db6d2454c5ac77a405ed9b9a52c 372 SUPERFAMILY SSF53901 2 204 4.74E-47 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS33245 f98c6db6d2454c5ac77a405ed9b9a52c 372 PIRSF PIRSF000451 1 349 8.7E-112 T 09-03-2017 IPR011141 Polyketide synthase, type III GO:0009058|GO:0016747 TK78_RS33245 f98c6db6d2454c5ac77a405ed9b9a52c 372 Gene3D G3DSA:3.40.47.10 205 347 2.2E-32 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS33245 f98c6db6d2454c5ac77a405ed9b9a52c 372 Pfam PF00195 Chalcone and stilbene synthases, N-terminal domain 8 197 3.4E-17 T 09-03-2017 IPR001099 Chalcone/stilbene synthase, N-terminal TK78_RS33245 f98c6db6d2454c5ac77a405ed9b9a52c 372 Gene3D G3DSA:3.40.47.10 2 199 1.5E-55 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS33245 f98c6db6d2454c5ac77a405ed9b9a52c 372 Pfam PF02797 Chalcone and stilbene synthases, C-terminal domain 212 343 2.1E-18 T 09-03-2017 IPR012328 Chalcone/stilbene synthase, C-terminal TK78_RS33245 f98c6db6d2454c5ac77a405ed9b9a52c 372 SUPERFAMILY SSF53901 203 346 1.61E-36 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS03355 0a96fb070924524f4f7e1d81de2b7f1a 288 Gene3D G3DSA:3.40.50.1820 2 286 4.7E-32 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS03355 0a96fb070924524f4f7e1d81de2b7f1a 288 SUPERFAMILY SSF53474 2 285 3.11E-27 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS03355 0a96fb070924524f4f7e1d81de2b7f1a 288 Pfam PF00561 alpha/beta hydrolase fold 42 129 1.2E-11 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS02750 74408ecfe1d9e9b60509556e8f5a49bf 189 Pfam PF01609 Transposase DDE domain 45 179 1.4E-20 T 09-03-2017 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 TK78_RS08065 279032f41c22792e5397af63d95ac2a0 365 ProSitePatterns PS01315 Phosphatidate cytidylyltransferase signature. 319 345 - T 09-03-2017 IPR000374 Phosphatidate cytidylyltransferase GO:0016020|GO:0016772 KEGG: 00564+2.7.7.41|KEGG: 04070+2.7.7.41|MetaCyc: PWY-5667|MetaCyc: PWY-5981 TK78_RS08065 279032f41c22792e5397af63d95ac2a0 365 Pfam PF01148 Cytidylyltransferase family 105 361 8.9E-64 T 09-03-2017 TK78_RS34285 316ffdd2086efbb73483fec7f2854ca5 673 TIGRFAM TIGR00829 FRU: PTS system, Fru family, IIB component 178 260 1.6E-24 T 09-03-2017 IPR003353 Phosphotransferase system, fructose-specific IIB subunit GO:0009401|GO:0022877 TK78_RS34285 316ffdd2086efbb73483fec7f2854ca5 673 SUPERFAMILY SSF52794 176 274 3.14E-29 T 09-03-2017 IPR003501 Phosphotransferase system, EIIB component, type 2/3 GO:0008982|GO:0009401 TK78_RS34285 316ffdd2086efbb73483fec7f2854ca5 673 Pfam PF02302 PTS system, Lactose/Cellobiose specific IIB subunit 179 268 1.6E-14 T 09-03-2017 IPR003501 Phosphotransferase system, EIIB component, type 2/3 GO:0008982|GO:0009401 TK78_RS34285 316ffdd2086efbb73483fec7f2854ca5 673 Gene3D G3DSA:3.40.930.10 2 148 5.6E-41 T 09-03-2017 IPR002178 PTS EIIA type-2 domain TK78_RS34285 316ffdd2086efbb73483fec7f2854ca5 673 SUPERFAMILY SSF55804 2 145 4.45E-32 T 09-03-2017 IPR016152 Phosphotransferase/anion transporter GO:0005215|GO:0006810 Reactome: R-HSA-425381 TK78_RS34285 316ffdd2086efbb73483fec7f2854ca5 673 Pfam PF00359 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 4 144 1.6E-30 T 09-03-2017 IPR002178 PTS EIIA type-2 domain TK78_RS34285 316ffdd2086efbb73483fec7f2854ca5 673 Gene3D G3DSA:3.40.50.2300 175 274 4.7E-36 T 09-03-2017 TK78_RS34285 316ffdd2086efbb73483fec7f2854ca5 673 Pfam PF02378 Phosphotransferase system, EIIC 316 593 7.3E-18 T 09-03-2017 IPR003352 Phosphotransferase system, EIIC GO:0008982|GO:0009401|GO:0016020 TK78_RS34285 316ffdd2086efbb73483fec7f2854ca5 673 TIGRFAM TIGR01427 PTS_IIC_fructo: PTS system, Fru family, IIC component 310 645 1.1E-112 T 09-03-2017 IPR006327 Phosphotransferase system, fructose IIC component GO:0005351|GO:0008982|GO:0009401|GO:0016021 TK78_RS34760 fbe3745eebeb6eac8790ea38db8d3fb9 225 SUPERFAMILY SSF52540 2 199 5.33E-37 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS34760 fbe3745eebeb6eac8790ea38db8d3fb9 225 Gene3D G3DSA:3.40.50.300 1 199 3.6E-36 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS34760 fbe3745eebeb6eac8790ea38db8d3fb9 225 SMART SM00382 26 210 0.0037 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS34760 fbe3745eebeb6eac8790ea38db8d3fb9 225 Pfam PF00005 ABC transporter 17 149 1.4E-15 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS31725 bd2cdfc52eb7e4b8f3ffea160136c39d 291 Gene3D G3DSA:3.10.129.10 126 286 2.2E-54 T 09-03-2017 IPR029069 HotDog domain TK78_RS31725 bd2cdfc52eb7e4b8f3ffea160136c39d 291 SUPERFAMILY SSF54637 5 113 3.38E-42 T 09-03-2017 IPR029069 HotDog domain TK78_RS31725 bd2cdfc52eb7e4b8f3ffea160136c39d 291 Gene3D G3DSA:3.10.129.10 4 113 9.6E-49 T 09-03-2017 IPR029069 HotDog domain TK78_RS31725 bd2cdfc52eb7e4b8f3ffea160136c39d 291 SUPERFAMILY SSF54637 117 286 1.77E-49 T 09-03-2017 IPR029069 HotDog domain TK78_RS31725 bd2cdfc52eb7e4b8f3ffea160136c39d 291 Pfam PF13622 Thioesterase-like superfamily 33 284 5.1E-63 T 09-03-2017 TK78_RS23320 4f9a85f979f6f2d946c34238cadb428e 227 Gene3D G3DSA:3.30.160.70 122 200 1.2E-19 T 09-03-2017 TK78_RS23320 4f9a85f979f6f2d946c34238cadb428e 227 Gene3D G3DSA:1.10.10.60 79 121 1.8E-5 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS23320 4f9a85f979f6f2d946c34238cadb428e 227 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 29 69 - T 09-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 TK78_RS23320 4f9a85f979f6f2d946c34238cadb428e 227 SUPERFAMILY SSF46689 27 73 1.21E-9 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS23320 4f9a85f979f6f2d946c34238cadb428e 227 Pfam PF12833 Helix-turn-helix domain 46 122 2.6E-18 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS23320 4f9a85f979f6f2d946c34238cadb428e 227 SMART SM00342 40 122 2.5E-19 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS23320 4f9a85f979f6f2d946c34238cadb428e 227 SUPERFAMILY SSF53155 129 198 5.89E-9 T 09-03-2017 IPR008332 Methylguanine DNA methyltransferase, ribonuclease-like domain GO:0003908|GO:0006281 Reactome: R-HSA-5657655 TK78_RS23320 4f9a85f979f6f2d946c34238cadb428e 227 Gene3D G3DSA:1.10.10.60 23 78 3.8E-20 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS11775 01ce84f6cf0c4070b605ceabe665b265 673 Gene3D G3DSA:3.40.30.10 20 145 1.3E-33 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS11775 01ce84f6cf0c4070b605ceabe665b265 673 PIRSF PIRSF006402 1 672 3.5E-201 T 09-03-2017 IPR024705 Spermatogenesis-associated protein 20 TK78_RS11775 01ce84f6cf0c4070b605ceabe665b265 673 SUPERFAMILY SSF52833 2 127 8.66E-31 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS11775 01ce84f6cf0c4070b605ceabe665b265 673 SUPERFAMILY SSF48208 189 535 1.02E-69 T 09-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 TK78_RS11775 01ce84f6cf0c4070b605ceabe665b265 673 Pfam PF03190 Protein of unknown function, DUF255 3 163 2.9E-75 T 09-03-2017 IPR004879 Domain of unknown function DUF255 TK78_RS11775 01ce84f6cf0c4070b605ceabe665b265 673 Gene3D G3DSA:1.50.10.10 408 563 8.7E-4 T 09-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 TK78_RS11775 01ce84f6cf0c4070b605ceabe665b265 673 Gene3D G3DSA:1.50.10.10 189 320 4.7E-17 T 09-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 TK78_RS08820 722c5738c09f3e7c1cbcce86459cbc1d 185 SUPERFAMILY SSF55729 8 175 2.16E-38 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS08820 722c5738c09f3e7c1cbcce86459cbc1d 185 Gene3D G3DSA:3.40.630.30 8 176 3.8E-42 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS08820 722c5738c09f3e7c1cbcce86459cbc1d 185 Pfam PF13302 Acetyltransferase (GNAT) domain 12 151 1.1E-18 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS31270 3ce9c20671704efd8a7691c41933a70a 407 SUPERFAMILY SSF56059 99 319 6.51E-30 T 09-03-2017 TK78_RS31270 3ce9c20671704efd8a7691c41933a70a 407 Pfam PF13535 ATP-grasp domain 144 283 1.9E-10 T 09-03-2017 TK78_RS31270 3ce9c20671704efd8a7691c41933a70a 407 Gene3D G3DSA:3.30.470.20 100 391 4.5E-21 T 09-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 TK78_RS32120 25fe880484d8ccf89887636861db6e1b 200 Gene3D G3DSA:1.10.357.10 11 195 1.4E-26 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS32120 25fe880484d8ccf89887636861db6e1b 200 SUPERFAMILY SSF46689 12 91 1.95E-13 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS32120 25fe880484d8ccf89887636861db6e1b 200 Pfam PF00440 Bacterial regulatory proteins, tetR family 22 68 1.1E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS21665 daf19fdc9617ba25515d4d240d2766fc 785 Pfam PF08924 Domain of unknown function (DUF1906) 310 435 1.5E-30 T 09-03-2017 IPR015020 Protein of unknown function DUF1906 TK78_RS21665 daf19fdc9617ba25515d4d240d2766fc 785 SUPERFAMILY SSF51445 298 480 1.56E-35 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS21665 daf19fdc9617ba25515d4d240d2766fc 785 Gene3D G3DSA:3.20.20.80 299 483 3.8E-43 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS21665 daf19fdc9617ba25515d4d240d2766fc 785 SUPERFAMILY SSF47090 73 137 3.92E-6 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS01610 81a03c01e4dc45b43aa6ebd77422b09c 388 Pfam PF13439 Glycosyltransferase Family 4 20 179 2.6E-28 T 09-03-2017 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 TK78_RS01610 81a03c01e4dc45b43aa6ebd77422b09c 388 SUPERFAMILY SSF53756 12 375 2.2E-84 T 09-03-2017 TK78_RS01610 81a03c01e4dc45b43aa6ebd77422b09c 388 Pfam PF13692 Glycosyl transferases group 1 206 339 2.6E-35 T 09-03-2017 TK78_RS01610 81a03c01e4dc45b43aa6ebd77422b09c 388 Gene3D G3DSA:3.40.50.2000 167 352 2.8E-38 T 09-03-2017 TK78_RS32395 a364ef2566ddd128f9b4c990421c82dd 566 Gene3D G3DSA:3.40.50.1820 75 161 1.6E-53 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS32395 a364ef2566ddd128f9b4c990421c82dd 566 Gene3D G3DSA:3.40.50.1820 216 340 1.6E-53 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS32395 a364ef2566ddd128f9b4c990421c82dd 566 Gene3D G3DSA:3.40.50.1820 436 554 1.6E-53 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS32395 a364ef2566ddd128f9b4c990421c82dd 566 Pfam PF00561 alpha/beta hydrolase fold 110 540 1.6E-38 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS32395 a364ef2566ddd128f9b4c990421c82dd 566 SUPERFAMILY SSF53474 95 158 2.03E-22 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS32395 a364ef2566ddd128f9b4c990421c82dd 566 SUPERFAMILY SSF53474 215 309 2.03E-22 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS32395 a364ef2566ddd128f9b4c990421c82dd 566 SUPERFAMILY SSF53474 446 551 2.03E-22 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS11735 14fbdf58a5f800743743c4cc6bfe5346 403 Gene3D G3DSA:3.90.1150.10 278 400 7.6E-40 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS11735 14fbdf58a5f800743743c4cc6bfe5346 403 Gene3D G3DSA:3.40.640.10 51 277 4.0E-69 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS11735 14fbdf58a5f800743743c4cc6bfe5346 403 Pfam PF00155 Aminotransferase class I and II 34 393 9.1E-53 T 09-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TK78_RS11735 14fbdf58a5f800743743c4cc6bfe5346 403 SUPERFAMILY SSF53383 7 398 4.57E-96 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS03345 3f48d2191bdf5450720b69cd9562c271 230 Hamap MF_00801 Endonuclease V [nfi]. 14 228 32.736 T 09-03-2017 IPR007581 Endonuclease V GO:0004519|GO:0006281 TK78_RS03345 3f48d2191bdf5450720b69cd9562c271 230 Pfam PF04493 Endonuclease V 25 218 9.3E-66 T 09-03-2017 IPR007581 Endonuclease V GO:0004519|GO:0006281 TK78_RS30050 fca90fe15a67f6d34be6f740a0197d27 658 Pfam PF03129 Anticodon binding domain 561 648 8.2E-20 T 09-03-2017 IPR004154 Anticodon-binding TK78_RS30050 fca90fe15a67f6d34be6f740a0197d27 658 Gene3D G3DSA:3.30.54.20 131 203 2.3E-11 T 09-03-2017 TK78_RS30050 fca90fe15a67f6d34be6f740a0197d27 658 Pfam PF00587 tRNA synthetase class II core domain (G, H, P, S and T) 341 549 5.4E-36 T 09-03-2017 IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS30050 fca90fe15a67f6d34be6f740a0197d27 658 Pfam PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 189 235 3.6E-13 T 09-03-2017 IPR012947 Threonyl/alanyl tRNA synthetase, SAD GO:0005524|GO:0016876|GO:0043039 TK78_RS30050 fca90fe15a67f6d34be6f740a0197d27 658 SUPERFAMILY SSF52954 547 653 5.89E-29 T 09-03-2017 IPR004154 Anticodon-binding TK78_RS30050 fca90fe15a67f6d34be6f740a0197d27 658 SUPERFAMILY SSF55186 64 257 6.28E-56 T 09-03-2017 IPR018163 Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain GO:0000166 TK78_RS30050 fca90fe15a67f6d34be6f740a0197d27 658 SMART SM00863 179 235 2.7E-21 T 09-03-2017 IPR012947 Threonyl/alanyl tRNA synthetase, SAD GO:0005524|GO:0016876|GO:0043039 TK78_RS30050 fca90fe15a67f6d34be6f740a0197d27 658 Gene3D G3DSA:3.30.930.10 258 550 1.5E-104 T 09-03-2017 TK78_RS30050 fca90fe15a67f6d34be6f740a0197d27 658 PRINTS PR01047 Threonyl-tRNA synthetase signature 484 512 1.1E-51 T 09-03-2017 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 TK78_RS30050 fca90fe15a67f6d34be6f740a0197d27 658 PRINTS PR01047 Threonyl-tRNA synthetase signature 527 540 1.1E-51 T 09-03-2017 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 TK78_RS30050 fca90fe15a67f6d34be6f740a0197d27 658 PRINTS PR01047 Threonyl-tRNA synthetase signature 348 376 1.1E-51 T 09-03-2017 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 TK78_RS30050 fca90fe15a67f6d34be6f740a0197d27 658 PRINTS PR01047 Threonyl-tRNA synthetase signature 381 404 1.1E-51 T 09-03-2017 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 TK78_RS30050 fca90fe15a67f6d34be6f740a0197d27 658 PRINTS PR01047 Threonyl-tRNA synthetase signature 554 566 1.1E-51 T 09-03-2017 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 TK78_RS30050 fca90fe15a67f6d34be6f740a0197d27 658 Gene3D G3DSA:3.30.980.10 204 240 1.2E-43 T 09-03-2017 TK78_RS30050 fca90fe15a67f6d34be6f740a0197d27 658 Gene3D G3DSA:3.30.980.10 66 129 1.2E-43 T 09-03-2017 TK78_RS30050 fca90fe15a67f6d34be6f740a0197d27 658 SUPERFAMILY SSF55681 259 546 1.21E-91 T 09-03-2017 TK78_RS30050 fca90fe15a67f6d34be6f740a0197d27 658 TIGRFAM TIGR00418 thrS: threonine--tRNA ligase 72 649 2.4E-198 T 09-03-2017 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 TK78_RS30050 fca90fe15a67f6d34be6f740a0197d27 658 Hamap MF_00184 Threonine--tRNA ligase [thrS]. 66 654 33.228 T 09-03-2017 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 TK78_RS30050 fca90fe15a67f6d34be6f740a0197d27 658 Gene3D G3DSA:3.40.50.800 551 655 1.6E-30 T 09-03-2017 IPR004154 Anticodon-binding TK78_RS20540 6635f1d12be69132f90bd14f898b2976 864 TIGRFAM TIGR00423 TIGR00423: radical SAM domain protein, CofH subfamily 530 838 9.7E-107 T 09-03-2017 IPR020050 FO synthase, subunit 2 GO:0016765 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198 TK78_RS20540 6635f1d12be69132f90bd14f898b2976 864 TIGRFAM TIGR03550 F420_cofG: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofG subunit 72 400 5.9E-145 T 09-03-2017 IPR019939 CofG family GO:0009108|GO:0016765|GO:0051539 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198 TK78_RS20540 6635f1d12be69132f90bd14f898b2976 864 TIGRFAM TIGR03551 F420_cofH: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit 496 840 9.8E-161 T 09-03-2017 IPR019940 CofH family GO:0016765 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198 TK78_RS20540 6635f1d12be69132f90bd14f898b2976 864 Pfam PF04055 Radical SAM superfamily 79 261 1.0E-14 T 09-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 TK78_RS20540 6635f1d12be69132f90bd14f898b2976 864 Pfam PF04055 Radical SAM superfamily 538 698 1.6E-14 T 09-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 TK78_RS20540 6635f1d12be69132f90bd14f898b2976 864 SUPERFAMILY SSF102114 493 804 1.07E-50 T 09-03-2017 TK78_RS20540 6635f1d12be69132f90bd14f898b2976 864 Hamap MF_01611 FO synthase subunit 1 [cofG]. 71 402 50.772 T 09-03-2017 IPR019939 CofG family GO:0009108|GO:0016765|GO:0051539 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198 TK78_RS20540 6635f1d12be69132f90bd14f898b2976 864 Hamap MF_01612 FO synthase subunit 2 [cofH]. 477 841 48.664 T 09-03-2017 IPR019940 CofH family GO:0016765 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198 TK78_RS20540 6635f1d12be69132f90bd14f898b2976 864 SUPERFAMILY SSF102114 34 377 7.72E-38 T 09-03-2017 TK78_RS20540 6635f1d12be69132f90bd14f898b2976 864 SMART SM00729 534 759 0.022 T 09-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 TK78_RS20540 6635f1d12be69132f90bd14f898b2976 864 SMART SM00729 75 312 7.5E-8 T 09-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 TK78_RS20540 6635f1d12be69132f90bd14f898b2976 864 Gene3D G3DSA:3.20.20.70 494 824 2.8E-76 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS20540 6635f1d12be69132f90bd14f898b2976 864 Gene3D G3DSA:3.20.20.70 31 363 3.9E-68 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS16790 61e5360b3b4f04e16970c369f9894ca7 387 Gene3D G3DSA:2.40.110.10 116 211 8.9E-38 T 09-03-2017 TK78_RS16790 61e5360b3b4f04e16970c369f9894ca7 387 SUPERFAMILY SSF56645 15 235 8.25E-67 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS16790 61e5360b3b4f04e16970c369f9894ca7 387 SUPERFAMILY SSF47203 220 385 2.9E-26 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS16790 61e5360b3b4f04e16970c369f9894ca7 387 Gene3D G3DSA:1.10.540.10 5 113 7.3E-21 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS16790 61e5360b3b4f04e16970c369f9894ca7 387 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 117 205 5.2E-22 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS16790 61e5360b3b4f04e16970c369f9894ca7 387 Gene3D G3DSA:1.20.140.10 212 384 1.6E-38 T 09-03-2017 TK78_RS16790 61e5360b3b4f04e16970c369f9894ca7 387 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 222 378 2.3E-32 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS16790 61e5360b3b4f04e16970c369f9894ca7 387 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 6 112 7.9E-19 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS14110 ae7513790b27d05c3d42e699551b80c7 478 Gene3D G3DSA:3.30.450.40 310 469 9.4E-14 T 09-03-2017 IPR029016 GAF domain-like TK78_RS14110 ae7513790b27d05c3d42e699551b80c7 478 SMART SM00091 172 237 0.0019 T 09-03-2017 IPR000014 PAS domain TK78_RS14110 ae7513790b27d05c3d42e699551b80c7 478 SMART SM00091 48 116 4.1E-8 T 09-03-2017 IPR000014 PAS domain TK78_RS14110 ae7513790b27d05c3d42e699551b80c7 478 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 48 170 3.4E-14 T 09-03-2017 IPR000014 PAS domain TK78_RS14110 ae7513790b27d05c3d42e699551b80c7 478 Pfam PF00989 PAS fold 49 159 1.6E-11 T 09-03-2017 IPR013767 PAS fold GO:0006355 TK78_RS14110 ae7513790b27d05c3d42e699551b80c7 478 SUPERFAMILY SSF55785 162 290 4.01E-11 T 09-03-2017 IPR000014 PAS domain TK78_RS14110 ae7513790b27d05c3d42e699551b80c7 478 Gene3D G3DSA:3.30.450.20 48 159 6.4E-18 T 09-03-2017 TK78_RS14110 ae7513790b27d05c3d42e699551b80c7 478 SUPERFAMILY SSF55781 338 469 3.14E-8 T 09-03-2017 IPR029016 GAF domain-like TK78_RS14110 ae7513790b27d05c3d42e699551b80c7 478 Pfam PF08448 PAS fold 178 293 1.4E-7 T 09-03-2017 IPR013656 PAS fold-4 TK78_RS14110 ae7513790b27d05c3d42e699551b80c7 478 Gene3D G3DSA:3.30.450.20 163 291 5.5E-13 T 09-03-2017 TK78_RS14110 ae7513790b27d05c3d42e699551b80c7 478 SUPERFAMILY SSF55785 48 156 4.36E-19 T 09-03-2017 IPR000014 PAS domain TK78_RS30315 1cbf6d4114ea8321f4bf8d91ac107438 379 PRINTS PR00097 Anthranilate synthase component II signature 349 362 1.8E-5 T 09-03-2017 TK78_RS30315 1cbf6d4114ea8321f4bf8d91ac107438 379 PRINTS PR00097 Anthranilate synthase component II signature 230 239 1.8E-5 T 09-03-2017 TK78_RS30315 1cbf6d4114ea8321f4bf8d91ac107438 379 PRINTS PR00097 Anthranilate synthase component II signature 258 269 1.8E-5 T 09-03-2017 TK78_RS30315 1cbf6d4114ea8321f4bf8d91ac107438 379 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 275 292 5.1E-30 T 09-03-2017 TK78_RS30315 1cbf6d4114ea8321f4bf8d91ac107438 379 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 227 241 5.1E-30 T 09-03-2017 TK78_RS30315 1cbf6d4114ea8321f4bf8d91ac107438 379 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 258 274 5.1E-30 T 09-03-2017 TK78_RS30315 1cbf6d4114ea8321f4bf8d91ac107438 379 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 300 311 5.1E-30 T 09-03-2017 TK78_RS30315 1cbf6d4114ea8321f4bf8d91ac107438 379 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 188 202 5.1E-30 T 09-03-2017 TK78_RS30315 1cbf6d4114ea8321f4bf8d91ac107438 379 Gene3D G3DSA:3.40.50.880 161 377 9.2E-62 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS30315 1cbf6d4114ea8321f4bf8d91ac107438 379 Pfam PF00988 Carbamoyl-phosphate synthase small chain, CPSase domain 12 138 3.6E-52 T 09-03-2017 IPR002474 Carbamoyl-phosphate synthase, small subunit N-terminal domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 TK78_RS30315 1cbf6d4114ea8321f4bf8d91ac107438 379 Gene3D G3DSA:3.50.30.20 11 144 9.1E-59 T 09-03-2017 IPR002474 Carbamoyl-phosphate synthase, small subunit N-terminal domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 TK78_RS30315 1cbf6d4114ea8321f4bf8d91ac107438 379 SMART SM01097 10 140 7.9E-88 T 09-03-2017 IPR002474 Carbamoyl-phosphate synthase, small subunit N-terminal domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 TK78_RS30315 1cbf6d4114ea8321f4bf8d91ac107438 379 Pfam PF00117 Glutamine amidotransferase class-I 192 372 6.6E-38 T 09-03-2017 IPR017926 Glutamine amidotransferase TK78_RS30315 1cbf6d4114ea8321f4bf8d91ac107438 379 Hamap MF_01209 Carbamoyl-phosphate synthase small chain [carA]. 10 378 46.132 T 09-03-2017 IPR006274 Carbamoyl-phosphate synthase, small subunit GO:0004088|GO:0006207|GO:0006541 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 TK78_RS30315 1cbf6d4114ea8321f4bf8d91ac107438 379 SUPERFAMILY SSF52021 11 144 3.14E-55 T 09-03-2017 IPR002474 Carbamoyl-phosphate synthase, small subunit N-terminal domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 TK78_RS30315 1cbf6d4114ea8321f4bf8d91ac107438 379 PRINTS PR00096 Glutamine amidotransferase superfamily signature 349 362 8.0E-11 T 09-03-2017 TK78_RS30315 1cbf6d4114ea8321f4bf8d91ac107438 379 PRINTS PR00096 Glutamine amidotransferase superfamily signature 258 269 8.0E-11 T 09-03-2017 TK78_RS30315 1cbf6d4114ea8321f4bf8d91ac107438 379 PRINTS PR00096 Glutamine amidotransferase superfamily signature 230 239 8.0E-11 T 09-03-2017 TK78_RS30315 1cbf6d4114ea8321f4bf8d91ac107438 379 SUPERFAMILY SSF52317 158 377 1.2E-49 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS30315 1cbf6d4114ea8321f4bf8d91ac107438 379 TIGRFAM TIGR01368 CPSaseIIsmall: carbamoyl-phosphate synthase, small subunit 12 375 2.9E-135 T 09-03-2017 IPR006274 Carbamoyl-phosphate synthase, small subunit GO:0004088|GO:0006207|GO:0006541 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 TK78_RS34460 dd1b5a05dd4cdcd426007a52693b9528 185 Pfam PF00440 Bacterial regulatory proteins, tetR family 3 39 4.8E-10 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS34460 dd1b5a05dd4cdcd426007a52693b9528 185 Gene3D G3DSA:1.10.357.10 2 170 2.2E-31 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS34460 dd1b5a05dd4cdcd426007a52693b9528 185 SUPERFAMILY SSF48498 60 167 1.78E-16 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS34460 dd1b5a05dd4cdcd426007a52693b9528 185 SUPERFAMILY SSF46689 2 56 1.13E-9 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS34460 dd1b5a05dd4cdcd426007a52693b9528 185 Pfam PF13977 Bacterial transcriptional repressor 65 172 6.1E-11 T 09-03-2017 TK78_RS04900 4b5d79f38215271aebed4aeaa3a401d4 427 SMART SM00387 319 420 6.2E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS04900 4b5d79f38215271aebed4aeaa3a401d4 427 PIRSF PIRSF037434 1 425 1.4E-129 T 09-03-2017 IPR017205 Signal transduction histidine kinase, ChrS TK78_RS04900 4b5d79f38215271aebed4aeaa3a401d4 427 Gene3D G3DSA:3.30.565.10 321 420 1.2E-11 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS04900 4b5d79f38215271aebed4aeaa3a401d4 427 SUPERFAMILY SSF55874 290 418 7.39E-18 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS04900 4b5d79f38215271aebed4aeaa3a401d4 427 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 324 419 5.3E-8 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS04900 4b5d79f38215271aebed4aeaa3a401d4 427 PRINTS PR00344 Bacterial sensor protein C-terminal signature 380 398 1.1E-6 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS04900 4b5d79f38215271aebed4aeaa3a401d4 427 PRINTS PR00344 Bacterial sensor protein C-terminal signature 355 369 1.1E-6 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS04900 4b5d79f38215271aebed4aeaa3a401d4 427 PRINTS PR00344 Bacterial sensor protein C-terminal signature 404 417 1.1E-6 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS04900 4b5d79f38215271aebed4aeaa3a401d4 427 Pfam PF07730 Histidine kinase 216 282 3.5E-16 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS17095 dab31de6e27d732b8b182d8b06bd3b55 360 Pfam PF00149 Calcineurin-like phosphoesterase 92 307 1.7E-9 T 09-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 TK78_RS17095 dab31de6e27d732b8b182d8b06bd3b55 360 SUPERFAMILY SSF56300 89 178 8.14E-35 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS17095 dab31de6e27d732b8b182d8b06bd3b55 360 SUPERFAMILY SSF56300 210 347 8.14E-35 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS17095 dab31de6e27d732b8b182d8b06bd3b55 360 Gene3D G3DSA:3.60.21.10 75 357 5.0E-36 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS17095 dab31de6e27d732b8b182d8b06bd3b55 360 PRINTS PR00114 Serine/threonine phosphatase family signature 91 118 2.4E-5 T 09-03-2017 IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase GO:0016787 KEGG: 04660+3.1.3.16 TK78_RS17095 dab31de6e27d732b8b182d8b06bd3b55 360 PRINTS PR00114 Serine/threonine phosphatase family signature 128 155 2.4E-5 T 09-03-2017 IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase GO:0016787 KEGG: 04660+3.1.3.16 TK78_RS11305 35f99c84ba7bba81b468a5a1656a6250 145 SUPERFAMILY SSF141322 78 138 1.83E-6 T 09-03-2017 TK78_RS11305 35f99c84ba7bba81b468a5a1656a6250 145 Pfam PF01957 NfeD-like C-terminal, partner-binding 5 140 7.9E-19 T 09-03-2017 IPR002810 NfeD-like, C-terminal domain TK78_RS11305 35f99c84ba7bba81b468a5a1656a6250 145 Gene3D G3DSA:2.40.50.140 81 140 2.8E-23 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS00805 6206721a64744a0144bdc31f6f561170 445 SUPERFAMILY SSF54631 213 347 1.89E-25 T 09-03-2017 TK78_RS00805 6206721a64744a0144bdc31f6f561170 445 SMART SM01091 355 434 5.2E-18 T 09-03-2017 IPR005170 Transporter-associated domain TK78_RS00805 6206721a64744a0144bdc31f6f561170 445 Pfam PF03471 Transporter associated domain 362 431 1.1E-16 T 09-03-2017 IPR005170 Transporter-associated domain TK78_RS00805 6206721a64744a0144bdc31f6f561170 445 Pfam PF01595 Domain of unknown function DUF21 8 201 7.5E-33 T 09-03-2017 IPR002550 Domain of unknown function DUF21 TK78_RS00805 6206721a64744a0144bdc31f6f561170 445 SUPERFAMILY SSF56176 361 433 4.36E-16 T 09-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 TK78_RS00805 6206721a64744a0144bdc31f6f561170 445 Gene3D G3DSA:3.10.580.10 209 330 1.6E-18 T 09-03-2017 TK78_RS00805 6206721a64744a0144bdc31f6f561170 445 Gene3D G3DSA:3.30.465.10 331 431 1.6E-21 T 09-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 TK78_RS00805 6206721a64744a0144bdc31f6f561170 445 Pfam PF00571 CBS domain 220 272 6.1E-4 T 09-03-2017 IPR000644 CBS domain TK78_RS00805 6206721a64744a0144bdc31f6f561170 445 Pfam PF00571 CBS domain 285 335 0.0026 T 09-03-2017 IPR000644 CBS domain TK78_RS13225 ad2dba4b67795425afb8e2674da95217 1161 Pfam PF04563 RNA polymerase beta subunit 66 409 1.6E-20 T 09-03-2017 IPR007644 RNA polymerase, beta subunit, protrusion GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13225 ad2dba4b67795425afb8e2674da95217 1161 Pfam PF10385 RNA polymerase beta subunit external 1 domain 502 568 1.0E-24 T 09-03-2017 IPR019462 DNA-directed RNA polymerase, beta subunit, external 1 domain GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13225 ad2dba4b67795425afb8e2674da95217 1161 Pfam PF00562 RNA polymerase Rpb2, domain 6 630 1047 6.8E-155 T 09-03-2017 IPR007120 DNA-directed RNA polymerase, subunit 2, domain 6 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13225 ad2dba4b67795425afb8e2674da95217 1161 ProSitePatterns PS01166 RNA polymerases beta chain signature. 868 880 - T 09-03-2017 IPR007121 RNA polymerase, beta subunit, conserved site GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13225 ad2dba4b67795425afb8e2674da95217 1161 Gene3D G3DSA:2.40.270.10 698 725 1.4E-74 T 09-03-2017 IPR007120 DNA-directed RNA polymerase, subunit 2, domain 6 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13225 ad2dba4b67795425afb8e2674da95217 1161 Gene3D G3DSA:2.40.270.10 865 1025 1.4E-74 T 09-03-2017 IPR007120 DNA-directed RNA polymerase, subunit 2, domain 6 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13225 ad2dba4b67795425afb8e2674da95217 1161 Gene3D G3DSA:2.40.50.100 628 697 2.0E-25 T 09-03-2017 TK78_RS13225 ad2dba4b67795425afb8e2674da95217 1161 Gene3D G3DSA:3.90.1110.10 171 340 3.5E-69 T 09-03-2017 IPR007642 RNA polymerase Rpb2, domain 2 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13225 ad2dba4b67795425afb8e2674da95217 1161 TIGRFAM TIGR02013 rpoB: DNA-directed RNA polymerase, beta subunit 236 842 0.0 T 09-03-2017 IPR010243 DNA-directed RNA polymerase beta subunit, bacterial-type GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13225 ad2dba4b67795425afb8e2674da95217 1161 Pfam PF04561 RNA polymerase Rpb2, domain 2 169 365 1.0E-29 T 09-03-2017 IPR007642 RNA polymerase Rpb2, domain 2 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13225 ad2dba4b67795425afb8e2674da95217 1161 Gene3D G3DSA:2.30.150.10 503 568 5.8E-27 T 09-03-2017 IPR019462 DNA-directed RNA polymerase, beta subunit, external 1 domain GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13225 ad2dba4b67795425afb8e2674da95217 1161 SUPERFAMILY SSF64484 22 1133 0.0 T 09-03-2017 TK78_RS13225 ad2dba4b67795425afb8e2674da95217 1161 Pfam PF04565 RNA polymerase Rpb2, domain 3 424 492 1.8E-28 T 09-03-2017 IPR007645 RNA polymerase Rpb2, domain 3 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13225 ad2dba4b67795425afb8e2674da95217 1161 Pfam PF04560 RNA polymerase Rpb2, domain 7 1049 1123 4.0E-27 T 09-03-2017 IPR007641 RNA polymerase Rpb2, domain 7 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13225 ad2dba4b67795425afb8e2674da95217 1161 Gene3D G3DSA:3.90.1100.10 354 502 6.5E-145 T 09-03-2017 TK78_RS13225 ad2dba4b67795425afb8e2674da95217 1161 Gene3D G3DSA:3.90.1100.10 29 169 6.5E-145 T 09-03-2017 TK78_RS13225 ad2dba4b67795425afb8e2674da95217 1161 Gene3D G3DSA:3.90.1100.10 571 625 6.5E-145 T 09-03-2017 TK78_RS13225 ad2dba4b67795425afb8e2674da95217 1161 Hamap MF_01321 DNA-directed RNA polymerase subunit beta [rpoB]. 23 1125 12.349 T 09-03-2017 IPR010243 DNA-directed RNA polymerase beta subunit, bacterial-type GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13225 ad2dba4b67795425afb8e2674da95217 1161 Gene3D G3DSA:2.40.50.150 734 864 4.3E-56 T 09-03-2017 IPR014724 RNA polymerase Rpb2, OB-fold GO:0003899 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS14685 a4d1735c19cd7c3e08ff556b41ad835a 218 Gene3D G3DSA:1.10.150.240 29 84 2.4E-11 T 09-03-2017 IPR023198 Phosphoglycolate phosphatase, domain 2 TK78_RS14685 a4d1735c19cd7c3e08ff556b41ad835a 218 Pfam PF12710 haloacid dehalogenase-like hydrolase 19 168 1.9E-10 T 09-03-2017 TK78_RS14685 a4d1735c19cd7c3e08ff556b41ad835a 218 SUPERFAMILY SSF56784 17 209 1.68E-32 T 09-03-2017 IPR023214 HAD-like domain TK78_RS14685 a4d1735c19cd7c3e08ff556b41ad835a 218 Gene3D G3DSA:3.40.50.1000 85 209 8.4E-19 T 09-03-2017 IPR023214 HAD-like domain TK78_RS03690 3c07cda404087244b884b46672b2195a 241 Gene3D G3DSA:3.40.630.30 117 235 5.1E-9 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS03690 3c07cda404087244b884b46672b2195a 241 Pfam PF12746 GNAT acetyltransferase 157 232 5.8E-9 T 09-03-2017 IPR027365 GNAT acetyltransferase YdfB-like TK78_RS03690 3c07cda404087244b884b46672b2195a 241 SUPERFAMILY SSF55729 147 234 8.98E-11 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS02985 53d37ee17769d4299c5f4ff4095a0660 340 Gene3D G3DSA:3.40.50.2300 50 180 2.1E-28 T 09-03-2017 TK78_RS02985 53d37ee17769d4299c5f4ff4095a0660 340 Gene3D G3DSA:1.10.260.40 1 49 4.7E-20 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS02985 53d37ee17769d4299c5f4ff4095a0660 340 SMART SM00354 1 71 4.0E-20 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS02985 53d37ee17769d4299c5f4ff4095a0660 340 SUPERFAMILY SSF53822 60 338 5.5E-62 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS02985 53d37ee17769d4299c5f4ff4095a0660 340 Gene3D G3DSA:3.40.50.2300 181 311 1.1E-47 T 09-03-2017 TK78_RS02985 53d37ee17769d4299c5f4ff4095a0660 340 Pfam PF00356 Bacterial regulatory proteins, lacI family 2 47 6.3E-15 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS02985 53d37ee17769d4299c5f4ff4095a0660 340 Pfam PF13377 Periplasmic binding protein-like domain 177 334 1.2E-34 T 09-03-2017 TK78_RS02985 53d37ee17769d4299c5f4ff4095a0660 340 SUPERFAMILY SSF47413 1 56 1.13E-13 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS07800 b88b996897a411a4e4a64c635aca11d5 1181 SUPERFAMILY SSF50494 17 186 5.97E-7 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS07800 b88b996897a411a4e4a64c635aca11d5 1181 SUPERFAMILY SSF52540 248 391 6.12E-8 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09335 a9356ec716d0609c1905ecb79daa9410 890 SUPERFAMILY SSF53756 4 762 1.88E-191 T 09-03-2017 TK78_RS09335 a9356ec716d0609c1905ecb79daa9410 890 ProSitePatterns PS00102 Phosphorylase pyridoxal-phosphate attachment site. 622 634 - T 09-03-2017 IPR000811 Glycosyl transferase, family 35 GO:0005975|GO:0008184 KEGG: 00500+2.4.1.1|MetaCyc: PWY-5941|MetaCyc: PWY-6731|MetaCyc: PWY-6737|MetaCyc: PWY-7238|Reactome: R-HSA-70221 TK78_RS09335 a9356ec716d0609c1905ecb79daa9410 890 Pfam PF11897 Protein of unknown function (DUF3417) 13 123 1.3E-32 T 09-03-2017 IPR024517 Glycogen phosphorylase, domain of unknown function DUF3417 KEGG: 00500+2.4.1.1|MetaCyc: PWY-5941|MetaCyc: PWY-6731|MetaCyc: PWY-6737|MetaCyc: PWY-7238 TK78_RS09335 a9356ec716d0609c1905ecb79daa9410 890 Pfam PF00343 Carbohydrate phosphorylase 528 644 2.7E-12 T 09-03-2017 IPR000811 Glycosyl transferase, family 35 GO:0005975|GO:0008184 KEGG: 00500+2.4.1.1|MetaCyc: PWY-5941|MetaCyc: PWY-6731|MetaCyc: PWY-6737|MetaCyc: PWY-7238|Reactome: R-HSA-70221 TK78_RS09335 a9356ec716d0609c1905ecb79daa9410 890 Pfam PF00343 Carbohydrate phosphorylase 128 173 6.8E-6 T 09-03-2017 IPR000811 Glycosyl transferase, family 35 GO:0005975|GO:0008184 KEGG: 00500+2.4.1.1|MetaCyc: PWY-5941|MetaCyc: PWY-6731|MetaCyc: PWY-6737|MetaCyc: PWY-7238|Reactome: R-HSA-70221 TK78_RS09335 a9356ec716d0609c1905ecb79daa9410 890 Gene3D G3DSA:3.40.50.2000 24 425 4.5E-85 T 09-03-2017 TK78_RS09335 a9356ec716d0609c1905ecb79daa9410 890 TIGRFAM TIGR02094 more_P_ylases: alpha-glucan phosphorylases 110 734 3.7E-223 T 09-03-2017 IPR011834 Alpha-glucan phosphorylase GO:0004645|GO:0005975|GO:0030170 KEGG: 00500+2.4.1.1|MetaCyc: PWY-5941|MetaCyc: PWY-6731|MetaCyc: PWY-6737|MetaCyc: PWY-7238 TK78_RS09335 a9356ec716d0609c1905ecb79daa9410 890 PIRSF PIRSF000460 1 820 8.3E-246 T 09-03-2017 IPR000811 Glycosyl transferase, family 35 GO:0005975|GO:0008184 KEGG: 00500+2.4.1.1|MetaCyc: PWY-5941|MetaCyc: PWY-6731|MetaCyc: PWY-6737|MetaCyc: PWY-7238|Reactome: R-HSA-70221 TK78_RS09335 a9356ec716d0609c1905ecb79daa9410 890 Gene3D G3DSA:3.40.50.2000 426 740 1.4E-88 T 09-03-2017 TK78_RS01795 7edcfb716f95b27e49377f5034d03724 489 Gene3D G3DSA:3.30.420.40 69 243 1.7E-20 T 09-03-2017 TK78_RS01795 7edcfb716f95b27e49377f5034d03724 489 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 255 442 3.0E-27 T 09-03-2017 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 TK78_RS01795 7edcfb716f95b27e49377f5034d03724 489 SUPERFAMILY SSF53067 8 243 7.12E-42 T 09-03-2017 TK78_RS01795 7edcfb716f95b27e49377f5034d03724 489 SUPERFAMILY SSF53067 252 477 1.53E-33 T 09-03-2017 TK78_RS01795 7edcfb716f95b27e49377f5034d03724 489 Gene3D G3DSA:3.30.420.40 364 478 1.7E-15 T 09-03-2017 TK78_RS01795 7edcfb716f95b27e49377f5034d03724 489 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 72 243 1.5E-23 T 09-03-2017 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 TK78_RS23600 2c2206ac83a3324e0d7f8599122067cd 304 Pfam PF08241 Methyltransferase domain 70 169 1.2E-16 T 09-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 TK78_RS23600 2c2206ac83a3324e0d7f8599122067cd 304 SUPERFAMILY SSF53335 35 227 1.99E-33 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS23600 2c2206ac83a3324e0d7f8599122067cd 304 Gene3D G3DSA:3.40.50.150 66 228 1.2E-28 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS24425 3bee26c16f3cb8ec868559a7b0d4eb8d 873 Pfam PF08264 Anticodon-binding domain of tRNA 612 755 4.0E-37 T 09-03-2017 IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding GO:0000166|GO:0006418 TK78_RS24425 3bee26c16f3cb8ec868559a7b0d4eb8d 873 Gene3D G3DSA:1.10.730.10 523 745 2.9E-72 T 09-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS24425 3bee26c16f3cb8ec868559a7b0d4eb8d 873 Hamap MF_02004 Valine--tRNA ligase [valS]. 15 871 15.096 T 09-03-2017 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9 TK78_RS24425 3bee26c16f3cb8ec868559a7b0d4eb8d 873 SUPERFAMILY SSF52374 351 579 5.16E-136 T 09-03-2017 TK78_RS24425 3bee26c16f3cb8ec868559a7b0d4eb8d 873 SUPERFAMILY SSF52374 14 205 5.16E-136 T 09-03-2017 TK78_RS24425 3bee26c16f3cb8ec868559a7b0d4eb8d 873 Gene3D G3DSA:3.90.740.10 176 354 5.1E-59 T 09-03-2017 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 TK78_RS24425 3bee26c16f3cb8ec868559a7b0d4eb8d 873 SUPERFAMILY SSF50677 204 344 2.35E-53 T 09-03-2017 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 TK78_RS24425 3bee26c16f3cb8ec868559a7b0d4eb8d 873 Gene3D G3DSA:3.40.50.620 38 175 5.6E-108 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS24425 3bee26c16f3cb8ec868559a7b0d4eb8d 873 Gene3D G3DSA:3.40.50.620 356 522 5.6E-108 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS24425 3bee26c16f3cb8ec868559a7b0d4eb8d 873 SUPERFAMILY SSF47323 582 819 3.92E-50 T 09-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS24425 3bee26c16f3cb8ec868559a7b0d4eb8d 873 SUPERFAMILY SSF46589 806 870 3.19E-14 T 09-03-2017 IPR010978 tRNA-binding arm GO:0000166 TK78_RS24425 3bee26c16f3cb8ec868559a7b0d4eb8d 873 PRINTS PR00986 Valyl-tRNA synthetase signature 49 60 1.2E-38 T 09-03-2017 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9 TK78_RS24425 3bee26c16f3cb8ec868559a7b0d4eb8d 873 PRINTS PR00986 Valyl-tRNA synthetase signature 481 499 1.2E-38 T 09-03-2017 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9 TK78_RS24425 3bee26c16f3cb8ec868559a7b0d4eb8d 873 PRINTS PR00986 Valyl-tRNA synthetase signature 450 471 1.2E-38 T 09-03-2017 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9 TK78_RS24425 3bee26c16f3cb8ec868559a7b0d4eb8d 873 PRINTS PR00986 Valyl-tRNA synthetase signature 241 258 1.2E-38 T 09-03-2017 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9 TK78_RS24425 3bee26c16f3cb8ec868559a7b0d4eb8d 873 PRINTS PR00986 Valyl-tRNA synthetase signature 356 369 1.2E-38 T 09-03-2017 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9 TK78_RS24425 3bee26c16f3cb8ec868559a7b0d4eb8d 873 Gene3D G3DSA:1.10.287.380 799 870 2.1E-8 T 09-03-2017 IPR019499 Valyl-tRNA synthetase, tRNA-binding arm GO:0000166|GO:0004832|GO:0005524|GO:0005737|GO:0006438 KEGG: 00970+6.1.1.9 TK78_RS24425 3bee26c16f3cb8ec868559a7b0d4eb8d 873 Pfam PF00133 tRNA synthetases class I (I, L, M and V) 28 567 5.0E-190 T 09-03-2017 IPR002300 Aminoacyl-tRNA synthetase, class Ia GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS24425 3bee26c16f3cb8ec868559a7b0d4eb8d 873 Pfam PF10458 Valyl tRNA synthetase tRNA binding arm 806 870 1.0E-16 T 09-03-2017 IPR019499 Valyl-tRNA synthetase, tRNA-binding arm GO:0000166|GO:0004832|GO:0005524|GO:0005737|GO:0006438 KEGG: 00970+6.1.1.9 TK78_RS24425 3bee26c16f3cb8ec868559a7b0d4eb8d 873 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 56 67 - T 09-03-2017 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS24425 3bee26c16f3cb8ec868559a7b0d4eb8d 873 TIGRFAM TIGR00422 valS: valine--tRNA ligase 16 848 0.0 T 09-03-2017 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9 TK78_RS17880 5dce7d7bbc28fa63f9210b349a05d529 189 Gene3D G3DSA:3.40.50.360 2 184 1.0E-40 T 09-03-2017 IPR029039 Flavoprotein-like domain TK78_RS17880 5dce7d7bbc28fa63f9210b349a05d529 189 Pfam PF03358 NADPH-dependent FMN reductase 9 142 2.4E-33 T 09-03-2017 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 TK78_RS17880 5dce7d7bbc28fa63f9210b349a05d529 189 SUPERFAMILY SSF52218 9 151 8.72E-33 T 09-03-2017 IPR029039 Flavoprotein-like domain TK78_RS09050 508715db1062e128fa60421203881abd 300 SUPERFAMILY SSF53901 18 293 3.95E-31 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS09050 508715db1062e128fa60421203881abd 300 Gene3D G3DSA:3.40.47.10 153 293 1.6E-28 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS09050 508715db1062e128fa60421203881abd 300 Pfam PF08541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal 205 293 5.0E-20 T 09-03-2017 IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, C-terminal KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 TK78_RS09050 508715db1062e128fa60421203881abd 300 Gene3D G3DSA:3.40.47.10 35 152 5.3E-14 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS32145 79238b3dd29b627c97ba9fe019b1a882 247 Pfam PF12833 Helix-turn-helix domain 162 236 8.7E-11 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS32145 79238b3dd29b627c97ba9fe019b1a882 247 SUPERFAMILY SSF51182 20 153 2.78E-9 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS32145 79238b3dd29b627c97ba9fe019b1a882 247 Pfam PF02311 AraC-like ligand binding domain 20 70 1.1E-6 T 09-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 TK78_RS32145 79238b3dd29b627c97ba9fe019b1a882 247 Gene3D G3DSA:2.60.120.10 21 70 9.0E-9 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS32145 79238b3dd29b627c97ba9fe019b1a882 247 SMART SM00342 156 238 7.7E-5 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS32145 79238b3dd29b627c97ba9fe019b1a882 247 Gene3D G3DSA:1.10.10.60 142 195 1.5E-8 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS15995 4d9e1685371a3c978996929618ebae9b 179 TIGRFAM TIGR00336 pyrE: orotate phosphoribosyltransferase 13 173 2.2E-33 T 09-03-2017 IPR004467 Orotate phosphoribosyl transferase domain GO:0004588 KEGG: 00240+2.4.2.10|KEGG: 00983+2.4.2.10|MetaCyc: PWY-5686|Reactome: R-HSA-500753 TK78_RS15995 4d9e1685371a3c978996929618ebae9b 179 Gene3D G3DSA:3.40.50.2020 9 176 1.6E-47 T 09-03-2017 IPR029057 Phosphoribosyltransferase-like TK78_RS15995 4d9e1685371a3c978996929618ebae9b 179 Pfam PF00156 Phosphoribosyl transferase domain 109 158 4.1E-10 T 09-03-2017 IPR000836 Phosphoribosyltransferase domain GO:0009116 TK78_RS15995 4d9e1685371a3c978996929618ebae9b 179 Hamap MF_01208 Orotate phosphoribosyltransferase [pyrE]. 1 179 24.252 T 09-03-2017 IPR023031 Orotate phosphoribosyltransferase GO:0004588|GO:0006221 KEGG: 00240+2.4.2.10|KEGG: 00983+2.4.2.10|MetaCyc: PWY-5686|Reactome: R-HSA-500753 TK78_RS15995 4d9e1685371a3c978996929618ebae9b 179 SUPERFAMILY SSF53271 7 175 7.6E-36 T 09-03-2017 IPR029057 Phosphoribosyltransferase-like TK78_RS27870 4fd1b8ea3c335dd7b777ab3a8a081502 336 TIGRFAM TIGR01534 GAPDH-I: glyceraldehyde-3-phosphate dehydrogenase, type I 4 327 2.1E-138 T 09-03-2017 IPR006424 Glyceraldehyde-3-phosphate dehydrogenase, type I GO:0006006|GO:0016620|GO:0050661|GO:0051287|GO:0055114 KEGG: 00010+1.2.1.12|KEGG: 00710+1.2.1.12|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27870 4fd1b8ea3c335dd7b777ab3a8a081502 336 Gene3D G3DSA:3.40.50.720 2 161 2.5E-77 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS27870 4fd1b8ea3c335dd7b777ab3a8a081502 336 PIRSF PIRSF000149 1 335 1.8E-136 T 09-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27870 4fd1b8ea3c335dd7b777ab3a8a081502 336 SMART SM00846 3 153 3.8E-95 T 09-03-2017 IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27870 4fd1b8ea3c335dd7b777ab3a8a081502 336 Pfam PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 158 315 2.0E-69 T 09-03-2017 IPR020829 Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27870 4fd1b8ea3c335dd7b777ab3a8a081502 336 SUPERFAMILY SSF55347 153 316 9.82E-71 T 09-03-2017 TK78_RS27870 4fd1b8ea3c335dd7b777ab3a8a081502 336 SUPERFAMILY SSF51735 2 152 8.69E-64 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS27870 4fd1b8ea3c335dd7b777ab3a8a081502 336 Pfam PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 3 153 1.1E-61 T 09-03-2017 IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27870 4fd1b8ea3c335dd7b777ab3a8a081502 336 Gene3D G3DSA:3.30.360.10 162 317 1.1E-74 T 09-03-2017 TK78_RS27870 4fd1b8ea3c335dd7b777ab3a8a081502 336 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 110 123 6.6E-40 T 09-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27870 4fd1b8ea3c335dd7b777ab3a8a081502 336 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 174 190 6.6E-40 T 09-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27870 4fd1b8ea3c335dd7b777ab3a8a081502 336 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 230 247 6.6E-40 T 09-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27870 4fd1b8ea3c335dd7b777ab3a8a081502 336 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 147 165 6.6E-40 T 09-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27870 4fd1b8ea3c335dd7b777ab3a8a081502 336 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 271 286 6.6E-40 T 09-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS30560 d8b7fca6ada895565035dbaf8bd0732b 548 Gene3D G3DSA:3.20.20.140 199 477 2.4E-34 T 09-03-2017 TK78_RS30560 d8b7fca6ada895565035dbaf8bd0732b 548 Gene3D G3DSA:3.20.20.140 81 93 2.4E-34 T 09-03-2017 TK78_RS30560 d8b7fca6ada895565035dbaf8bd0732b 548 SUPERFAMILY SSF51556 70 131 3.26E-37 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS30560 d8b7fca6ada895565035dbaf8bd0732b 548 SUPERFAMILY SSF51556 197 477 3.26E-37 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS30560 d8b7fca6ada895565035dbaf8bd0732b 548 SUPERFAMILY SSF51338 479 518 2.64E-12 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS30560 d8b7fca6ada895565035dbaf8bd0732b 548 SUPERFAMILY SSF51338 9 71 2.64E-12 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS30560 d8b7fca6ada895565035dbaf8bd0732b 548 Gene3D G3DSA:2.30.40.10 6 80 2.6E-13 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS30560 d8b7fca6ada895565035dbaf8bd0732b 548 Pfam PF07969 Amidohydrolase family 59 543 1.1E-100 T 09-03-2017 IPR013108 Amidohydrolase 3 TK78_RS29610 e64aed9712501e47dd32dc88e6776388 837 SMART SM00896 742 835 2.9E-39 T 09-03-2017 IPR005121 Phenylalanine-tRNA ligase, beta subunit, ferrodoxin-fold anticodon-binding GO:0000049|GO:0000287|GO:0004826|GO:0005524|GO:0006432|GO:0008033 KEGG: 00970+6.1.1.20 TK78_RS29610 e64aed9712501e47dd32dc88e6776388 837 SUPERFAMILY SSF50249 45 204 2.86E-32 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS29610 e64aed9712501e47dd32dc88e6776388 837 Pfam PF03483 B3/4 domain 221 400 5.9E-68 T 09-03-2017 IPR005146 B3/B4 tRNA-binding domain GO:0003723|GO:0004826 KEGG: 00970+6.1.1.20 TK78_RS29610 e64aed9712501e47dd32dc88e6776388 837 Pfam PF03147 Ferredoxin-fold anticodon binding domain 742 835 2.1E-22 T 09-03-2017 IPR005121 Phenylalanine-tRNA ligase, beta subunit, ferrodoxin-fold anticodon-binding GO:0000049|GO:0000287|GO:0004826|GO:0005524|GO:0006432|GO:0008033 KEGG: 00970+6.1.1.20 TK78_RS29610 e64aed9712501e47dd32dc88e6776388 837 SUPERFAMILY SSF46955 416 487 1.37E-14 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS29610 e64aed9712501e47dd32dc88e6776388 837 SMART SM00874 416 483 8.3E-20 T 09-03-2017 IPR005147 tRNA synthetase, B5-domain GO:0000287|GO:0003723|GO:0005524|GO:0006432 KEGG: 00970+6.1.1.20|Reactome: R-HSA-379716 TK78_RS29610 e64aed9712501e47dd32dc88e6776388 837 TIGRFAM TIGR00472 pheT_bact: phenylalanine--tRNA ligase, beta subunit 1 835 1.8E-190 T 09-03-2017 IPR004532 Phenylalanine-tRNA ligase, class IIc, beta subunit GO:0000287|GO:0004826|GO:0005524|GO:0005737|GO:0006432 KEGG: 00970+6.1.1.20 TK78_RS29610 e64aed9712501e47dd32dc88e6776388 837 Gene3D G3DSA:3.30.56.20 415 487 1.7E-21 T 09-03-2017 IPR005147 tRNA synthetase, B5-domain GO:0000287|GO:0003723|GO:0005524|GO:0006432 KEGG: 00970+6.1.1.20|Reactome: R-HSA-379716 TK78_RS29610 e64aed9712501e47dd32dc88e6776388 837 Gene3D G3DSA:2.40.50.140 46 162 3.2E-39 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS29610 e64aed9712501e47dd32dc88e6776388 837 Gene3D G3DSA:3.30.56.10 1 40 4.7E-18 T 09-03-2017 TK78_RS29610 e64aed9712501e47dd32dc88e6776388 837 Gene3D G3DSA:3.30.56.10 164 193 4.7E-18 T 09-03-2017 TK78_RS29610 e64aed9712501e47dd32dc88e6776388 837 Gene3D G3DSA:3.30.930.10 498 729 1.1E-63 T 09-03-2017 TK78_RS29610 e64aed9712501e47dd32dc88e6776388 837 Hamap MF_00283 Phenylalanine--tRNA ligase beta subunit [pheT]. 1 829 40.442 T 09-03-2017 IPR004532 Phenylalanine-tRNA ligase, class IIc, beta subunit GO:0000287|GO:0004826|GO:0005524|GO:0005737|GO:0006432 KEGG: 00970+6.1.1.20 TK78_RS29610 e64aed9712501e47dd32dc88e6776388 837 SUPERFAMILY SSF55681 479 595 6.96E-41 T 09-03-2017 TK78_RS29610 e64aed9712501e47dd32dc88e6776388 837 SUPERFAMILY SSF55681 625 728 6.96E-41 T 09-03-2017 TK78_RS29610 e64aed9712501e47dd32dc88e6776388 837 SMART SM00873 221 400 3.2E-83 T 09-03-2017 IPR005146 B3/B4 tRNA-binding domain GO:0003723|GO:0004826 KEGG: 00970+6.1.1.20 TK78_RS29610 e64aed9712501e47dd32dc88e6776388 837 Gene3D G3DSA:3.30.70.380 744 835 5.9E-28 T 09-03-2017 IPR005121 Phenylalanine-tRNA ligase, beta subunit, ferrodoxin-fold anticodon-binding GO:0000049|GO:0000287|GO:0004826|GO:0005524|GO:0006432|GO:0008033 KEGG: 00970+6.1.1.20 TK78_RS29610 e64aed9712501e47dd32dc88e6776388 837 Pfam PF01588 Putative tRNA binding domain 48 154 2.6E-20 T 09-03-2017 IPR002547 tRNA-binding domain GO:0000049 Reactome: R-HSA-379716 TK78_RS29610 e64aed9712501e47dd32dc88e6776388 837 SUPERFAMILY SSF54991 738 835 8.76E-25 T 09-03-2017 IPR005121 Phenylalanine-tRNA ligase, beta subunit, ferrodoxin-fold anticodon-binding GO:0000049|GO:0000287|GO:0004826|GO:0005524|GO:0006432|GO:0008033 KEGG: 00970+6.1.1.20 TK78_RS29610 e64aed9712501e47dd32dc88e6776388 837 Pfam PF03484 tRNA synthetase B5 domain 418 483 1.9E-16 T 09-03-2017 IPR005147 tRNA synthetase, B5-domain GO:0000287|GO:0003723|GO:0005524|GO:0006432 KEGG: 00970+6.1.1.20|Reactome: R-HSA-379716 TK78_RS29610 e64aed9712501e47dd32dc88e6776388 837 Gene3D G3DSA:3.50.40.10 209 410 1.9E-84 T 09-03-2017 IPR020825 Phenylalanyl-tRNA synthetase, B3/B4 Reactome: R-HSA-379716 TK78_RS29610 e64aed9712501e47dd32dc88e6776388 837 SUPERFAMILY SSF56037 206 411 1.28E-66 T 09-03-2017 IPR020825 Phenylalanyl-tRNA synthetase, B3/B4 Reactome: R-HSA-379716 TK78_RS32520 9926824deb4b7f5eff99c9d6a6b17790 143 Pfam PF03965 Penicillinase repressor 20 127 1.2E-19 T 09-03-2017 IPR005650 BlaI transcriptional regulatory family GO:0003677|GO:0045892 TK78_RS32520 9926824deb4b7f5eff99c9d6a6b17790 143 SUPERFAMILY SSF46785 20 128 3.72E-16 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32520 9926824deb4b7f5eff99c9d6a6b17790 143 Gene3D G3DSA:1.10.10.10 20 87 4.2E-14 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS27230 35a4e6ea5d3f6247c9a6fc814749f4ab 166 PIRSF PIRSF006181 8 166 3.5E-51 T 09-03-2017 IPR004369 Prolyl-tRNA editing protein, YbaK/EbsC TK78_RS27230 35a4e6ea5d3f6247c9a6fc814749f4ab 166 Gene3D G3DSA:3.90.960.10 8 164 2.0E-57 T 09-03-2017 IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain GO:0002161 KEGG: 00970+6.1.1.15 TK78_RS27230 35a4e6ea5d3f6247c9a6fc814749f4ab 166 Pfam PF04073 Aminoacyl-tRNA editing domain 42 154 2.4E-26 T 09-03-2017 IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain GO:0002161 KEGG: 00970+6.1.1.15 TK78_RS27230 35a4e6ea5d3f6247c9a6fc814749f4ab 166 SUPERFAMILY SSF55826 13 163 6.28E-43 T 09-03-2017 IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain GO:0002161 KEGG: 00970+6.1.1.15 TK78_RS27230 35a4e6ea5d3f6247c9a6fc814749f4ab 166 TIGRFAM TIGR00011 YbaK_EbsC: Cys-tRNA(Pro) deacylase 13 164 6.9E-55 T 09-03-2017 IPR004369 Prolyl-tRNA editing protein, YbaK/EbsC TK78_RS09515 459c3f3213416d0b5c83314cfbf56c52 257 Pfam PF01987 Mitochondrial biogenesis AIM24 25 210 3.8E-10 T 09-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 TK78_RS09515 459c3f3213416d0b5c83314cfbf56c52 257 Gene3D G3DSA:3.60.160.10 8 212 1.5E-23 T 09-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 TK78_RS09515 459c3f3213416d0b5c83314cfbf56c52 257 SUPERFAMILY SSF51219 16 212 7.59E-30 T 09-03-2017 IPR016031 Tryptophan RNA-binding attenuator protein-like domain TK78_RS03930 db7eca82206e84bd4ba496f9b1ea3595 1239 SUPERFAMILY SSF50952 54 339 1.15E-24 T 09-03-2017 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 TK78_RS03930 db7eca82206e84bd4ba496f9b1ea3595 1239 SUPERFAMILY SSF50952 405 481 1.15E-24 T 09-03-2017 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 TK78_RS03930 db7eca82206e84bd4ba496f9b1ea3595 1239 SUPERFAMILY SSF49299 505 590 3.27E-22 T 09-03-2017 IPR000601 PKD domain TK78_RS03930 db7eca82206e84bd4ba496f9b1ea3595 1239 SUPERFAMILY SSF52317 833 1055 2.52E-51 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS03930 db7eca82206e84bd4ba496f9b1ea3595 1239 Gene3D G3DSA:3.40.50.880 829 1054 2.1E-45 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS03930 db7eca82206e84bd4ba496f9b1ea3595 1239 Pfam PF06283 Trehalose utilisation 834 1045 2.2E-85 T 09-03-2017 IPR029010 ThuA-like domain TK78_RS03930 db7eca82206e84bd4ba496f9b1ea3595 1239 Gene3D G3DSA:2.120.10.30 51 506 1.4E-104 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS03930 db7eca82206e84bd4ba496f9b1ea3595 1239 Gene3D G3DSA:2.60.40.670 507 589 4.2E-23 T 09-03-2017 IPR000601 PKD domain TK78_RS03930 db7eca82206e84bd4ba496f9b1ea3595 1239 Pfam PF03422 Carbohydrate binding module (family 6) 702 824 1.2E-24 T 09-03-2017 IPR005084 Carbohydrate binding module family 6 GO:0030246 TK78_RS03930 db7eca82206e84bd4ba496f9b1ea3595 1239 Pfam PF06439 Domain of Unknown Function (DUF1080) 1059 1234 5.4E-44 T 09-03-2017 IPR010496 Domain of unknown function DUF1080 TK78_RS03930 db7eca82206e84bd4ba496f9b1ea3595 1239 Pfam PF00801 PKD domain 511 577 6.1E-13 T 09-03-2017 IPR000601 PKD domain TK78_RS03930 db7eca82206e84bd4ba496f9b1ea3595 1239 SMART SM00606 694 825 3.2E-35 T 09-03-2017 IPR006584 Cellulose binding, type IV GO:0030246 TK78_RS03930 db7eca82206e84bd4ba496f9b1ea3595 1239 SUPERFAMILY SSF49785 697 824 1.55E-20 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS03930 db7eca82206e84bd4ba496f9b1ea3595 1239 Gene3D G3DSA:2.60.120.260 696 825 1.3E-32 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS03930 db7eca82206e84bd4ba496f9b1ea3595 1239 SMART SM00089 507 590 1.9E-21 T 09-03-2017 IPR022409 PKD/Chitinase domain TK78_RS03930 db7eca82206e84bd4ba496f9b1ea3595 1239 Pfam PF07995 Glucose / Sorbosone dehydrogenase 70 342 1.5E-34 T 09-03-2017 IPR012938 Glucose/Sorbosone dehydrogenase GO:0005975|GO:0016901|GO:0048038 TK78_RS33970 81198a7ce1694631a9c05a545c775db8 333 SMART SM01092 226 324 7.4E-24 T 09-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal TK78_RS33970 81198a7ce1694631a9c05a545c775db8 333 Pfam PF00941 FAD binding domain in molybdopterin dehydrogenase 3 219 5.1E-56 T 09-03-2017 IPR002346 Molybdopterin dehydrogenase, FAD-binding GO:0016491|GO:0055114 TK78_RS33970 81198a7ce1694631a9c05a545c775db8 333 Gene3D G3DSA:3.30.390.50 225 326 1.6E-28 T 09-03-2017 TK78_RS33970 81198a7ce1694631a9c05a545c775db8 333 SUPERFAMILY SSF56176 2 219 1.78E-62 T 09-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 TK78_RS33970 81198a7ce1694631a9c05a545c775db8 333 Gene3D G3DSA:3.30.465.10 157 219 8.2E-37 T 09-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 TK78_RS33970 81198a7ce1694631a9c05a545c775db8 333 Gene3D G3DSA:3.30.465.10 57 113 8.2E-37 T 09-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 TK78_RS33970 81198a7ce1694631a9c05a545c775db8 333 SUPERFAMILY SSF55447 226 327 9.42E-24 T 09-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal TK78_RS33970 81198a7ce1694631a9c05a545c775db8 333 Pfam PF03450 CO dehydrogenase flavoprotein C-terminal domain 227 321 1.5E-15 T 09-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal TK78_RS33970 81198a7ce1694631a9c05a545c775db8 333 Gene3D G3DSA:3.30.43.10 2 51 3.0E-20 T 09-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 TK78_RS07830 ff5f7b2409a8e64e7589c8c59237d469 346 TIGRFAM TIGR01953 NusA: transcription termination factor NusA 77 321 1.3E-98 T 09-03-2017 IPR010213 Transcription termination factor NusA GO:0003723 TK78_RS07830 ff5f7b2409a8e64e7589c8c59237d469 346 SUPERFAMILY SSF50249 111 178 1.14E-14 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS07830 ff5f7b2409a8e64e7589c8c59237d469 346 Hamap MF_00945_B Transcription termination/antitermination protein NusA [nusA]. 1 344 25.835 T 09-03-2017 IPR030842 Transcription termination/antitermination protein NusA, bacterial GO:0006353|GO:0031564 TK78_RS07830 ff5f7b2409a8e64e7589c8c59237d469 346 Gene3D G3DSA:3.30.1480.10 4 101 1.9E-25 T 09-03-2017 IPR013735 Transcription factor NusA, N-terminal GO:0003700|GO:0031554 TK78_RS07830 ff5f7b2409a8e64e7589c8c59237d469 346 Gene3D G3DSA:3.30.300.20 178 256 1.1E-33 T 09-03-2017 IPR015946 K homology domain-like, alpha/beta TK78_RS07830 ff5f7b2409a8e64e7589c8c59237d469 346 Pfam PF13184 NusA-like KH domain 209 277 3.3E-27 T 09-03-2017 IPR025249 KH domain, NusA-like GO:0003723 TK78_RS07830 ff5f7b2409a8e64e7589c8c59237d469 346 SMART SM00316 112 177 0.0012 T 09-03-2017 IPR022967 RNA-binding domain, S1 TK78_RS07830 ff5f7b2409a8e64e7589c8c59237d469 346 Pfam PF00575 S1 RNA binding domain 113 175 2.6E-4 T 09-03-2017 IPR003029 S1 domain GO:0003676 TK78_RS07830 ff5f7b2409a8e64e7589c8c59237d469 346 Gene3D G3DSA:3.30.300.20 257 326 1.1E-30 T 09-03-2017 IPR015946 K homology domain-like, alpha/beta TK78_RS07830 ff5f7b2409a8e64e7589c8c59237d469 346 SMART SM00322 209 272 0.54 T 09-03-2017 IPR004087 K Homology domain GO:0003676 TK78_RS07830 ff5f7b2409a8e64e7589c8c59237d469 346 SMART SM00322 281 345 0.0015 T 09-03-2017 IPR004087 K Homology domain GO:0003676 TK78_RS07830 ff5f7b2409a8e64e7589c8c59237d469 346 SUPERFAMILY SSF54814 258 323 7.85E-16 T 09-03-2017 IPR009019 K homology domain, prokaryotic type GO:0003723 TK78_RS07830 ff5f7b2409a8e64e7589c8c59237d469 346 SUPERFAMILY SSF54814 179 257 3.79E-28 T 09-03-2017 IPR009019 K homology domain, prokaryotic type GO:0003723 TK78_RS07830 ff5f7b2409a8e64e7589c8c59237d469 346 Pfam PF08529 NusA N-terminal domain 6 102 9.9E-13 T 09-03-2017 IPR013735 Transcription factor NusA, N-terminal GO:0003700|GO:0031554 TK78_RS07830 ff5f7b2409a8e64e7589c8c59237d469 346 SUPERFAMILY SSF69705 3 101 5.1E-23 T 09-03-2017 IPR013735 Transcription factor NusA, N-terminal GO:0003700|GO:0031554 TK78_RS07830 ff5f7b2409a8e64e7589c8c59237d469 346 Gene3D G3DSA:2.40.50.140 108 177 4.2E-24 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS26865 4a4808549b7bf1cf9b6b03870eef996d 149 Gene3D G3DSA:3.30.530.20 4 145 3.1E-17 T 09-03-2017 IPR023393 START-like domain TK78_RS26865 4a4808549b7bf1cf9b6b03870eef996d 149 SUPERFAMILY SSF55961 1 146 6.7E-31 T 09-03-2017 TK78_RS26865 4a4808549b7bf1cf9b6b03870eef996d 149 Pfam PF10604 Polyketide cyclase / dehydrase and lipid transport 4 144 5.9E-16 T 09-03-2017 IPR019587 Polyketide cyclase/dehydrase TK78_RS25460 900ff14abbeb31cdec390f2263f593e4 343 Pfam PF08541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal 252 341 4.9E-31 T 09-03-2017 IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, C-terminal KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 TK78_RS25460 900ff14abbeb31cdec390f2263f593e4 343 Gene3D G3DSA:3.40.47.10 13 170 2.2E-53 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS25460 900ff14abbeb31cdec390f2263f593e4 343 TIGRFAM TIGR00747 fabH: 3-oxoacyl-[acyl-carrier-protein] synthase III 12 341 9.2E-107 T 09-03-2017 IPR004655 3-oxoacyl-[acyl-carrier-protein] synthase 3 GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 TK78_RS25460 900ff14abbeb31cdec390f2263f593e4 343 Hamap MF_01815 3-oxoacyl-[acyl-carrier-protein] synthase 3 [fabH]. 11 342 60.61 T 09-03-2017 IPR004655 3-oxoacyl-[acyl-carrier-protein] synthase 3 GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 TK78_RS25460 900ff14abbeb31cdec390f2263f593e4 343 Pfam PF08545 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III 116 193 2.1E-25 T 09-03-2017 IPR013751 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 TK78_RS25460 900ff14abbeb31cdec390f2263f593e4 343 Gene3D G3DSA:3.40.47.10 171 340 1.7E-46 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS25460 900ff14abbeb31cdec390f2263f593e4 343 SUPERFAMILY SSF53901 10 341 2.84E-59 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 SUPERFAMILY SSF53098 324 493 6.32E-31 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 SUPERFAMILY SSF56672 499 900 2.33E-139 T 09-03-2017 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 SMART SM00279 186 221 8.9E-15 T 09-03-2017 IPR008918 Helix-hairpin-helix motif, class 2 GO:0003677|GO:0003824 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 PRINTS PR00868 DNA-polymerase family A (pol I) signature 674 697 5.3E-76 T 09-03-2017 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 PRINTS PR00868 DNA-polymerase family A (pol I) signature 704 717 5.3E-76 T 09-03-2017 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 PRINTS PR00868 DNA-polymerase family A (pol I) signature 651 666 5.3E-76 T 09-03-2017 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 PRINTS PR00868 DNA-polymerase family A (pol I) signature 728 753 5.3E-76 T 09-03-2017 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 PRINTS PR00868 DNA-polymerase family A (pol I) signature 819 835 5.3E-76 T 09-03-2017 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 PRINTS PR00868 DNA-polymerase family A (pol I) signature 628 650 5.3E-76 T 09-03-2017 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 PRINTS PR00868 DNA-polymerase family A (pol I) signature 765 776 5.3E-76 T 09-03-2017 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 PRINTS PR00868 DNA-polymerase family A (pol I) signature 787 798 5.3E-76 T 09-03-2017 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 PRINTS PR00868 DNA-polymerase family A (pol I) signature 849 862 5.3E-76 T 09-03-2017 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 Pfam PF01367 5'-3' exonuclease, C-terminal SAM fold 185 277 6.3E-26 T 09-03-2017 IPR020045 5'-3' exonuclease, C-terminal domain GO:0003677|GO:0003824 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 Gene3D G3DSA:3.40.50.1010 15 198 3.7E-68 T 09-03-2017 IPR029060 PIN domain-like TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 Gene3D G3DSA:1.10.150.20 686 792 1.4E-31 T 09-03-2017 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 Gene3D G3DSA:1.10.150.20 199 258 4.7E-23 T 09-03-2017 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 Pfam PF02739 5'-3' exonuclease, N-terminal resolvase-like domain 15 183 3.4E-54 T 09-03-2017 IPR020046 5'-3' exonuclease, alpha-helical arch, N-terminal GO:0003677 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 SMART SM00482 659 866 5.3E-114 T 09-03-2017 IPR001098 DNA-directed DNA polymerase, family A, palm domain GO:0003677|GO:0003887|GO:0006260 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 SMART SM00475 12 274 1.5E-139 T 09-03-2017 IPR002421 5'-3' exonuclease, N-terminal GO:0003677 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 Pfam PF00476 DNA polymerase family A 525 899 6.8E-144 T 09-03-2017 IPR001098 DNA-directed DNA polymerase, family A, palm domain GO:0003677|GO:0003887|GO:0006260 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 TIGRFAM TIGR00593 pola: DNA polymerase I 16 901 5.6E-295 T 09-03-2017 IPR018320 DNA polymerase 1 GO:0003887|GO:0006260 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 Pfam PF01612 3'-5' exonuclease 360 450 8.2E-6 T 09-03-2017 IPR002562 3'-5' exonuclease domain GO:0003676|GO:0006139|GO:0008408 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 SUPERFAMILY SSF88723 10 183 1.81E-53 T 09-03-2017 IPR029060 PIN domain-like TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 Gene3D G3DSA:3.30.70.370 637 685 2.7E-65 T 09-03-2017 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 Gene3D G3DSA:3.30.70.370 793 901 2.7E-65 T 09-03-2017 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 SMART SM00474 321 492 8.6E-9 T 09-03-2017 IPR002562 3'-5' exonuclease domain GO:0003676|GO:0006139|GO:0008408 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 Gene3D G3DSA:3.30.420.10 324 516 7.0E-49 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 SUPERFAMILY SSF47807 184 289 7.33E-27 T 09-03-2017 IPR020045 5'-3' exonuclease, C-terminal domain GO:0003677|GO:0003824 TK78_RS27640 7c75d5d0088555324cd92613504581c7 903 Gene3D G3DSA:1.20.1060.10 517 636 2.2E-33 T 09-03-2017 TK78_RS21195 09851d9121e2090f01b14f707ca09992 451 Pfam PF03990 Domain of unknown function (DUF348) 176 204 4.0E-7 T 09-03-2017 IPR007137 Resuscitation-promoting factor, domain of unknown function DUF348 TK78_RS21195 09851d9121e2090f01b14f707ca09992 451 Pfam PF03990 Domain of unknown function (DUF348) 233 272 2.2E-11 T 09-03-2017 IPR007137 Resuscitation-promoting factor, domain of unknown function DUF348 TK78_RS21195 09851d9121e2090f01b14f707ca09992 451 Pfam PF03990 Domain of unknown function (DUF348) 119 158 1.5E-12 T 09-03-2017 IPR007137 Resuscitation-promoting factor, domain of unknown function DUF348 TK78_RS21195 09851d9121e2090f01b14f707ca09992 451 SUPERFAMILY SSF53955 372 448 3.97E-23 T 09-03-2017 IPR023346 Lysozyme-like domain TK78_RS21195 09851d9121e2090f01b14f707ca09992 451 SMART SM01208 286 364 7.4E-18 T 09-03-2017 IPR011098 G5 domain TK78_RS21195 09851d9121e2090f01b14f707ca09992 451 Pfam PF07501 G5 domain 290 362 3.3E-18 T 09-03-2017 IPR011098 G5 domain TK78_RS21195 09851d9121e2090f01b14f707ca09992 451 Pfam PF06737 Transglycosylase-like domain 372 445 3.7E-23 T 09-03-2017 IPR010618 Transglycosylase-like TK78_RS21195 09851d9121e2090f01b14f707ca09992 451 Gene3D G3DSA:1.10.530.10 354 449 3.4E-29 T 09-03-2017 TK78_RS19845 44cca09bae9e05e86fd6f5bb6f9c48db 304 SMART SM00478 51 203 1.2E-34 T 09-03-2017 IPR003265 HhH-GPD domain GO:0006284 Reactome: R-HSA-110357 TK78_RS19845 44cca09bae9e05e86fd6f5bb6f9c48db 304 Pfam PF00633 Helix-hairpin-helix motif 111 140 2.2E-6 T 09-03-2017 IPR000445 Helix-hairpin-helix motif GO:0003677 Reactome: R-HSA-110357 TK78_RS19845 44cca09bae9e05e86fd6f5bb6f9c48db 304 SUPERFAMILY SSF48150 19 230 3.61E-60 T 09-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 TK78_RS19845 44cca09bae9e05e86fd6f5bb6f9c48db 304 Gene3D G3DSA:1.10.1670.10 135 231 1.5E-33 T 09-03-2017 IPR023170 Helix-turn-helix, base-excision DNA repair, C-terminal Reactome: R-HSA-110357 TK78_RS19845 44cca09bae9e05e86fd6f5bb6f9c48db 304 Pfam PF00730 HhH-GPD superfamily base excision DNA repair protein 47 165 3.5E-11 T 09-03-2017 IPR003265 HhH-GPD domain GO:0006284 Reactome: R-HSA-110357 TK78_RS19845 44cca09bae9e05e86fd6f5bb6f9c48db 304 SMART SM00525 204 224 0.0027 T 09-03-2017 IPR003651 Endonuclease III-like, iron-sulphur cluster loop motif GO:0051539 Reactome: R-HSA-110357 TK78_RS19845 44cca09bae9e05e86fd6f5bb6f9c48db 304 ProSitePatterns PS01155 Endonuclease III family signature. 114 143 - T 09-03-2017 IPR004036 Endonuclease III-like, conserved site-2 Reactome: R-HSA-110357 TK78_RS19845 44cca09bae9e05e86fd6f5bb6f9c48db 304 Gene3D G3DSA:1.10.340.30 34 134 3.1E-34 T 09-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 TK78_RS02470 840562440575bc3b39d0d8a37aa79df0 588 Pfam PF00754 F5/8 type C domain 467 582 3.0E-24 T 09-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain TK78_RS02470 840562440575bc3b39d0d8a37aa79df0 588 Gene3D G3DSA:2.60.120.260 453 586 6.0E-31 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS02470 840562440575bc3b39d0d8a37aa79df0 588 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 110 265 5.7E-6 T 09-03-2017 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 TK78_RS02470 840562440575bc3b39d0d8a37aa79df0 588 SUPERFAMILY SSF49785 458 586 1.49E-28 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS02470 840562440575bc3b39d0d8a37aa79df0 588 Gene3D G3DSA:3.20.20.80 54 343 4.9E-32 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS02470 840562440575bc3b39d0d8a37aa79df0 588 SUPERFAMILY SSF51445 46 343 1.21E-41 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS17665 0e531dab44978600d934226fb61510af 329 SUPERFAMILY SSF50129 1 140 6.85E-39 T 09-03-2017 IPR011032 GroES-like TK78_RS17665 0e531dab44978600d934226fb61510af 329 Gene3D G3DSA:3.40.50.720 147 259 3.9E-33 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS17665 0e531dab44978600d934226fb61510af 329 SMART SM00829 10 323 9.1E-46 T 09-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 TK78_RS17665 0e531dab44978600d934226fb61510af 329 Pfam PF00107 Zinc-binding dehydrogenase 151 266 1.6E-30 T 09-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 TK78_RS17665 0e531dab44978600d934226fb61510af 329 Gene3D G3DSA:3.90.180.10 1 146 1.0E-48 T 09-03-2017 IPR011032 GroES-like TK78_RS17665 0e531dab44978600d934226fb61510af 329 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 28 87 6.1E-7 T 09-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 TK78_RS17665 0e531dab44978600d934226fb61510af 329 TIGRFAM TIGR02824 quinone_pig3: putative NAD(P)H quinone oxidoreductase, PIG3 family 1 324 1.0E-142 T 09-03-2017 IPR014189 Quinone oxidoreductase PIG3 Reactome: R-HSA-6803205 TK78_RS17665 0e531dab44978600d934226fb61510af 329 SUPERFAMILY SSF51735 111 286 1.42E-49 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS16660 38830ddb4f7e34b568483a9826f20c75 532 Gene3D G3DSA:3.30.565.10 325 509 3.0E-40 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS16660 38830ddb4f7e34b568483a9826f20c75 532 SMART SM00388 267 339 5.8E-21 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS16660 38830ddb4f7e34b568483a9826f20c75 532 SMART SM00387 391 511 1.2E-36 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS16660 38830ddb4f7e34b568483a9826f20c75 532 PRINTS PR00344 Bacterial sensor protein C-terminal signature 431 445 3.9E-11 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS16660 38830ddb4f7e34b568483a9826f20c75 532 PRINTS PR00344 Bacterial sensor protein C-terminal signature 495 508 3.9E-11 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS16660 38830ddb4f7e34b568483a9826f20c75 532 PRINTS PR00344 Bacterial sensor protein C-terminal signature 472 490 3.9E-11 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS16660 38830ddb4f7e34b568483a9826f20c75 532 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 392 509 1.6E-20 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS16660 38830ddb4f7e34b568483a9826f20c75 532 SUPERFAMILY SSF55874 328 509 3.93E-36 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS16660 38830ddb4f7e34b568483a9826f20c75 532 SUPERFAMILY SSF47384 257 340 6.87E-19 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS16660 38830ddb4f7e34b568483a9826f20c75 532 Pfam PF00672 HAMP domain 180 253 6.1E-11 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS16660 38830ddb4f7e34b568483a9826f20c75 532 Gene3D G3DSA:1.10.287.130 260 324 5.3E-20 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS16660 38830ddb4f7e34b568483a9826f20c75 532 SMART SM00304 197 259 1.1E-4 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS16660 38830ddb4f7e34b568483a9826f20c75 532 Pfam PF00512 His Kinase A (phospho-acceptor) domain 269 339 1.5E-19 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS33135 ad5af606c639691464e4c618b4962386 360 SUPERFAMILY SSF53822 71 354 3.14E-71 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS33135 ad5af606c639691464e4c618b4962386 360 Pfam PF13407 Periplasmic binding protein domain 83 334 8.6E-50 T 09-03-2017 IPR025997 Periplasmic binding protein TK78_RS33135 ad5af606c639691464e4c618b4962386 360 Gene3D G3DSA:3.40.50.2300 83 195 4.3E-31 T 09-03-2017 TK78_RS33135 ad5af606c639691464e4c618b4962386 360 Gene3D G3DSA:3.40.50.2300 196 354 3.8E-45 T 09-03-2017 TK78_RS15880 36b9bdf242371dc203223df7edb18412 315 Pfam PF03466 LysR substrate binding domain 92 294 2.5E-20 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS15880 36b9bdf242371dc203223df7edb18412 315 Gene3D G3DSA:3.40.190.10 179 257 1.8E-8 T 09-03-2017 TK78_RS15880 36b9bdf242371dc203223df7edb18412 315 Gene3D G3DSA:3.40.190.10 111 178 6.7E-5 T 09-03-2017 TK78_RS15880 36b9bdf242371dc203223df7edb18412 315 SUPERFAMILY SSF46785 5 87 7.26E-18 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS15880 36b9bdf242371dc203223df7edb18412 315 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 6 65 4.9E-17 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS15880 36b9bdf242371dc203223df7edb18412 315 Gene3D G3DSA:1.10.10.10 4 88 2.0E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS15880 36b9bdf242371dc203223df7edb18412 315 SUPERFAMILY SSF53850 93 295 7.06E-23 T 09-03-2017 TK78_RS17205 e092680910bd4e20504d407c68ed5bd1 491 Gene3D G3DSA:3.40.50.300 216 490 5.5E-119 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17205 e092680910bd4e20504d407c68ed5bd1 491 Gene3D G3DSA:1.10.860.10 56 158 2.3E-40 T 09-03-2017 IPR016136 DNA helicase DnaB, N-terminal/DNA primase DnaG, C-terminal TK78_RS17205 e092680910bd4e20504d407c68ed5bd1 491 TIGRFAM TIGR00665 DnaB: replicative DNA helicase 56 489 1.3E-166 T 09-03-2017 IPR007692 DNA helicase, DnaB type GO:0003677|GO:0003678|GO:0005524|GO:0006260 TK78_RS17205 e092680910bd4e20504d407c68ed5bd1 491 Pfam PF00772 DnaB-like helicase N terminal domain 56 157 3.9E-35 T 09-03-2017 IPR007693 DNA helicase, DnaB-like, N-terminal GO:0003678|GO:0005524|GO:0006260 TK78_RS17205 e092680910bd4e20504d407c68ed5bd1 491 Pfam PF03796 DnaB-like helicase C terminal domain 231 486 2.5E-109 T 09-03-2017 IPR007694 DNA helicase, DnaB-like, C-terminal GO:0003678|GO:0005524|GO:0006260 Reactome: R-HSA-2151201 TK78_RS17205 e092680910bd4e20504d407c68ed5bd1 491 SUPERFAMILY SSF52540 229 480 2.74E-51 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17205 e092680910bd4e20504d407c68ed5bd1 491 SMART SM00382 248 447 4.7E-4 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS17205 e092680910bd4e20504d407c68ed5bd1 491 SUPERFAMILY SSF48024 54 165 4.05E-37 T 09-03-2017 IPR007693 DNA helicase, DnaB-like, N-terminal GO:0003678|GO:0005524|GO:0006260 TK78_RS08860 9bf70bf090372ba87d48771d0bf4d7e7 730 SMART SM00267 247 413 2.5E-51 T 09-03-2017 IPR000160 GGDEF domain TK78_RS08860 9bf70bf090372ba87d48771d0bf4d7e7 730 Pfam PF00563 EAL domain 430 660 3.9E-69 T 09-03-2017 IPR001633 EAL domain TK78_RS08860 9bf70bf090372ba87d48771d0bf4d7e7 730 TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain 253 407 7.2E-35 T 09-03-2017 IPR000160 GGDEF domain TK78_RS08860 9bf70bf090372ba87d48771d0bf4d7e7 730 SMART SM00052 423 667 3.4E-101 T 09-03-2017 IPR001633 EAL domain TK78_RS08860 9bf70bf090372ba87d48771d0bf4d7e7 730 Gene3D G3DSA:3.20.20.450 429 674 2.3E-91 T 09-03-2017 IPR001633 EAL domain TK78_RS08860 9bf70bf090372ba87d48771d0bf4d7e7 730 Pfam PF00990 Diguanylate cyclase, GGDEF domain 255 407 2.7E-42 T 09-03-2017 IPR000160 GGDEF domain TK78_RS08860 9bf70bf090372ba87d48771d0bf4d7e7 730 SUPERFAMILY SSF141868 429 675 7.72E-82 T 09-03-2017 IPR001633 EAL domain TK78_RS08860 9bf70bf090372ba87d48771d0bf4d7e7 730 SUPERFAMILY SSF55073 258 409 2.2E-44 T 09-03-2017 IPR029787 Nucleotide cyclase TK78_RS08860 9bf70bf090372ba87d48771d0bf4d7e7 730 Gene3D G3DSA:3.30.70.270 255 416 5.2E-51 T 09-03-2017 TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 Gene3D G3DSA:3.30.70.250 681 744 1.2E-7 T 09-03-2017 TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 SUPERFAMILY SSF51735 1177 1419 5.44E-49 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 183 199 - T 09-03-2017 IPR018201 Beta-ketoacyl synthase, active site TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 Pfam PF00550 Phosphopantetheine attachment site 1474 1540 7.1E-11 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 Pfam PF00698 Acyl transferase domain 554 871 4.5E-82 T 09-03-2017 IPR014043 Acyl transferase TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 SMART SM01294 1473 1540 1.9E-4 T 09-03-2017 TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 Gene3D G3DSA:3.40.47.10 283 448 7.0E-62 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 SUPERFAMILY SSF51735 963 1166 3.16E-43 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 34 270 6.4E-83 T 09-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 SMART SM00823 Phosphopantetheine attachment site 1472 1544 1.2E-28 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 SUPERFAMILY SSF55048 681 745 3.27E-12 T 09-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 Pfam PF08990 Erythronolide synthase docking 2 27 7.8E-11 T 09-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 Gene3D G3DSA:3.40.47.10 36 282 1.2E-85 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1181 1364 4.6E-47 T 09-03-2017 TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 SUPERFAMILY SSF52151 552 681 7.06E-66 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 SUPERFAMILY SSF52151 746 845 7.06E-66 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 556 854 1.4E-115 T 09-03-2017 IPR020801 Polyketide synthase, acyl transferase domain TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 SUPERFAMILY SSF47336 1465 1551 8.77E-21 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1499 1514 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 SMART SM00825 Beta-ketoacyl synthase 36 448 1.2E-206 T 09-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 398 517 3.0E-13 T 09-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 SUPERFAMILY SSF101173 3 34 7.32E-8 T 09-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 SUPERFAMILY SSF53901 31 394 1.08E-106 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 Pfam PF08659 KR domain 1181 1362 5.9E-52 T 09-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 Gene3D G3DSA:3.40.366.10 745 856 9.1E-72 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 Gene3D G3DSA:3.40.366.10 547 675 9.1E-72 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 278 395 3.5E-44 T 09-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 Gene3D G3DSA:1.10.1200.10 1468 1542 3.1E-21 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS07110 be751ce15be10198e1819e25d535460d 1627 Gene3D G3DSA:3.40.50.720 1181 1401 8.0E-39 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS09355 8a1aee4ad49ba34a9f86715084510e07 808 Gene3D G3DSA:2.60.40.1180 703 807 1.1E-33 T 09-03-2017 IPR013780 Glycosyl hydrolase, all-beta TK78_RS09355 8a1aee4ad49ba34a9f86715084510e07 808 Hamap MF_00685 1,4-alpha-glucan branching enzyme GlgB [glgB]. 181 808 43.506 T 09-03-2017 IPR006407 1,4-alpha-glucan-branching enzyme, GlgB GO:0003844|GO:0005978 KEGG: 00500+2.4.1.18|MetaCyc: PWY-5067|MetaCyc: PWY-622|Reactome: R-HSA-3322077|Reactome: R-HSA-3878781 TK78_RS09355 8a1aee4ad49ba34a9f86715084510e07 808 PIRSF PIRSF000463 92 808 5.1E-298 T 09-03-2017 IPR006407 1,4-alpha-glucan-branching enzyme, GlgB GO:0003844|GO:0005978 KEGG: 00500+2.4.1.18|MetaCyc: PWY-5067|MetaCyc: PWY-622|Reactome: R-HSA-3322077|Reactome: R-HSA-3878781 TK78_RS09355 8a1aee4ad49ba34a9f86715084510e07 808 Pfam PF00128 Alpha amylase, catalytic domain 347 419 2.5E-10 T 09-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 TK78_RS09355 8a1aee4ad49ba34a9f86715084510e07 808 Pfam PF02922 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) 205 287 1.1E-19 T 09-03-2017 IPR004193 Glycoside hydrolase, family 13, N-terminal GO:0004553|GO:0005975 Reactome: R-HSA-3322077|Reactome: R-HSA-3878781 TK78_RS09355 8a1aee4ad49ba34a9f86715084510e07 808 SMART SM00642 330 670 6.1E-8 T 09-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 TK78_RS09355 8a1aee4ad49ba34a9f86715084510e07 808 Gene3D G3DSA:3.20.20.80 326 689 1.4E-92 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS09355 8a1aee4ad49ba34a9f86715084510e07 808 Gene3D G3DSA:2.60.40.10 193 301 5.5E-34 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS09355 8a1aee4ad49ba34a9f86715084510e07 808 Gene3D G3DSA:2.60.40.10 98 184 2.5E-15 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS09355 8a1aee4ad49ba34a9f86715084510e07 808 TIGRFAM TIGR01515 branching_enzym: 1,4-alpha-glucan branching enzyme 189 806 6.8E-302 T 09-03-2017 IPR006407 1,4-alpha-glucan-branching enzyme, GlgB GO:0003844|GO:0005978 KEGG: 00500+2.4.1.18|MetaCyc: PWY-5067|MetaCyc: PWY-622|Reactome: R-HSA-3322077|Reactome: R-HSA-3878781 TK78_RS09355 8a1aee4ad49ba34a9f86715084510e07 808 SUPERFAMILY SSF81296 195 300 1.96E-21 T 09-03-2017 IPR014756 Immunoglobulin E-set TK78_RS09355 8a1aee4ad49ba34a9f86715084510e07 808 SUPERFAMILY SSF51445 251 697 3.57E-111 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS09355 8a1aee4ad49ba34a9f86715084510e07 808 Pfam PF02806 Alpha amylase, C-terminal all-beta domain 708 807 4.7E-19 T 09-03-2017 IPR006048 Alpha-amylase/branching enzyme, C-terminal all beta GO:0003824|GO:0005975|GO:0043169 KEGG: 00500+2.4.1.18|MetaCyc: PWY-5067|MetaCyc: PWY-622 TK78_RS09355 8a1aee4ad49ba34a9f86715084510e07 808 SUPERFAMILY SSF51011 703 807 1.8E-29 T 09-03-2017 TK78_RS09355 8a1aee4ad49ba34a9f86715084510e07 808 SUPERFAMILY SSF81296 99 194 1.28E-18 T 09-03-2017 IPR014756 Immunoglobulin E-set TK78_RS09665 a31de3ac90fc2407386fc378a5753bd6 124 SUPERFAMILY SSF51344 5 86 1.96E-21 T 09-03-2017 IPR020546 ATPase, F1 complex, delta/epsilon subunit, N-terminal GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 TK78_RS09665 a31de3ac90fc2407386fc378a5753bd6 124 TIGRFAM TIGR01216 ATP_synt_epsi: ATP synthase F1, epsilon subunit 5 117 1.2E-25 T 09-03-2017 IPR001469 ATPase, F1 complex, delta/epsilon subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 TK78_RS09665 a31de3ac90fc2407386fc378a5753bd6 124 Gene3D G3DSA:2.60.15.10 4 91 2.9E-25 T 09-03-2017 IPR020546 ATPase, F1 complex, delta/epsilon subunit, N-terminal GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 TK78_RS09665 a31de3ac90fc2407386fc378a5753bd6 124 Pfam PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 5 83 5.5E-24 T 09-03-2017 IPR020546 ATPase, F1 complex, delta/epsilon subunit, N-terminal GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 TK78_RS09665 a31de3ac90fc2407386fc378a5753bd6 124 ProDom PD000944 ATP SYNTHASE ION EPSILON SUBUNIT HYDROLASE CF1 SYNTHESIS CHAIN HYDROGEN 18 90 2.0E-32 T 09-03-2017 IPR020546 ATPase, F1 complex, delta/epsilon subunit, N-terminal GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 TK78_RS09665 a31de3ac90fc2407386fc378a5753bd6 124 Hamap MF_00530 ATP synthase epsilon chain [atpC]. 3 120 18.752 T 09-03-2017 IPR001469 ATPase, F1 complex, delta/epsilon subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 TK78_RS00330 2afa9dcf33ba11422382bbe11ccd2385 209 Pfam PF08241 Methyltransferase domain 54 146 5.2E-16 T 09-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 TK78_RS00330 2afa9dcf33ba11422382bbe11ccd2385 209 SUPERFAMILY SSF53335 3 185 1.66E-31 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS00330 2afa9dcf33ba11422382bbe11ccd2385 209 Gene3D G3DSA:3.40.50.150 4 184 4.1E-29 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 SUPERFAMILY SSF48452 918 1060 4.17E-16 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 Gene3D G3DSA:1.10.10.10 10 94 4.9E-8 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 SUPERFAMILY SSF48452 757 932 9.84E-21 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 Pfam PF13424 Tetratricopeptide repeat 826 885 1.9E-9 T 09-03-2017 TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 Pfam PF13424 Tetratricopeptide repeat 978 1051 1.5E-10 T 09-03-2017 TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 Pfam PF13424 Tetratricopeptide repeat 898 970 4.1E-10 T 09-03-2017 TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 Gene3D G3DSA:3.40.50.300 296 367 2.7E-6 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 SUPERFAMILY SSF52540 287 552 1.23E-28 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 Pfam PF00486 Transcriptional regulatory protein, C terminal 22 76 1.7E-7 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 SMART SM01043 101 245 2.3E-37 T 09-03-2017 IPR005158 Bacterial transcriptional activator domain TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 Pfam PF13191 AAA ATPase domain 301 440 1.4E-8 T 09-03-2017 TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 Gene3D G3DSA:1.25.40.10 697 886 7.5E-18 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 SUPERFAMILY SSF48452 99 270 1.52E-33 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 SMART SM00028 1019 1052 28.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 SMART SM00028 939 972 13.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 SMART SM00028 899 932 12.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 SMART SM00028 979 1012 0.19 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 SMART SM00028 819 852 49.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 SMART SM00028 859 892 33.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 SMART SM00862 15 93 4.4E-5 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 PRINTS PR00364 Disease resistance protein signature 325 340 3.1E-5 T 09-03-2017 TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 PRINTS PR00364 Disease resistance protein signature 402 416 3.1E-5 T 09-03-2017 TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 PRINTS PR00364 Disease resistance protein signature 487 501 3.1E-5 T 09-03-2017 TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 Pfam PF03704 Bacterial transcriptional activator domain 101 245 2.3E-35 T 09-03-2017 IPR005158 Bacterial transcriptional activator domain TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 SUPERFAMILY SSF46894 2 79 1.45E-12 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS09840 c56a9937d981ef591be1d8a7feace9f8 1074 Gene3D G3DSA:1.25.40.10 899 1064 3.3E-22 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS34010 af2124041c8404a470c20cd3f821a8d7 449 TIGRFAM TIGR03814 Gln_ase: glutaminase A 21 306 1.2E-101 T 09-03-2017 IPR015868 Glutaminase GO:0004359|GO:0006541 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|Reactome: R-HSA-210500|Reactome: R-HSA-5628897|Reactome: R-HSA-70614 TK78_RS34010 af2124041c8404a470c20cd3f821a8d7 449 Hamap MF_00313 Glutaminase [glsA]. 3 307 40.927 T 09-03-2017 IPR015868 Glutaminase GO:0004359|GO:0006541 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|Reactome: R-HSA-210500|Reactome: R-HSA-5628897|Reactome: R-HSA-70614 TK78_RS34010 af2124041c8404a470c20cd3f821a8d7 449 Gene3D G3DSA:3.30.750.24 339 411 1.8E-7 T 09-03-2017 IPR002645 STAS domain TK78_RS34010 af2124041c8404a470c20cd3f821a8d7 449 SUPERFAMILY SSF56601 8 307 4.51E-109 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS34010 af2124041c8404a470c20cd3f821a8d7 449 Gene3D G3DSA:3.40.710.10 6 307 3.0E-119 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS34010 af2124041c8404a470c20cd3f821a8d7 449 Pfam PF04960 Glutaminase 24 306 2.2E-109 T 09-03-2017 IPR015868 Glutaminase GO:0004359|GO:0006541 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|Reactome: R-HSA-210500|Reactome: R-HSA-5628897|Reactome: R-HSA-70614 TK78_RS34010 af2124041c8404a470c20cd3f821a8d7 449 SUPERFAMILY SSF52091 335 413 2.94E-8 T 09-03-2017 IPR002645 STAS domain TK78_RS20290 c204fce0c12669ec3c395e8f0e8342f0 182 Pfam PF00583 Acetyltransferase (GNAT) family 68 147 3.4E-11 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS20290 c204fce0c12669ec3c395e8f0e8342f0 182 Gene3D G3DSA:3.40.630.30 13 173 1.2E-32 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS20290 c204fce0c12669ec3c395e8f0e8342f0 182 SUPERFAMILY SSF55729 13 173 1.03E-25 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS13840 586f0cbd604f24a1c225f9f3f3206513 390 Gene3D G3DSA:3.40.47.10 26 114 3.4E-12 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS13840 586f0cbd604f24a1c225f9f3f3206513 390 Gene3D G3DSA:3.40.47.10 199 225 3.4E-12 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS13840 586f0cbd604f24a1c225f9f3f3206513 390 Pfam PF02803 Thiolase, C-terminal domain 246 359 4.7E-8 T 09-03-2017 IPR020617 Thiolase, C-terminal GO:0008152|GO:0016747 TK78_RS13840 586f0cbd604f24a1c225f9f3f3206513 390 PIRSF PIRSF000429 3 381 3.3E-30 T 09-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 TK78_RS13840 586f0cbd604f24a1c225f9f3f3206513 390 SUPERFAMILY SSF53901 9 227 2.24E-18 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS13840 586f0cbd604f24a1c225f9f3f3206513 390 SUPERFAMILY SSF53901 245 366 7.25E-24 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS13840 586f0cbd604f24a1c225f9f3f3206513 390 Gene3D G3DSA:3.40.47.10 147 184 1.4E-17 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS13840 586f0cbd604f24a1c225f9f3f3206513 390 Gene3D G3DSA:3.40.47.10 244 363 1.4E-17 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS03250 e11b2a78808e1c759a78ca1881ea082d 813 Pfam PF12836 Helix-hairpin-helix motif 493 557 6.2E-28 T 09-03-2017 TK78_RS03250 e11b2a78808e1c759a78ca1881ea082d 813 Pfam PF16921 Tex protein YqgF-like domain 328 453 4.6E-52 T 09-03-2017 IPR032639 Tex protein, YqgF-like domain TK78_RS03250 e11b2a78808e1c759a78ca1881ea082d 813 SUPERFAMILY SSF53098 323 471 6.83E-51 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS03250 e11b2a78808e1c759a78ca1881ea082d 813 SUPERFAMILY SSF47781 472 560 1.89E-26 T 09-03-2017 IPR010994 RuvA domain 2-like TK78_RS03250 e11b2a78808e1c759a78ca1881ea082d 813 Pfam PF09371 Tex-like protein N-terminal domain 9 192 2.3E-66 T 09-03-2017 IPR018974 Tex-like protein, N-terminal TK78_RS03250 e11b2a78808e1c759a78ca1881ea082d 813 Pfam PF00575 S1 RNA binding domain 651 722 2.8E-19 T 09-03-2017 IPR003029 S1 domain GO:0003676 TK78_RS03250 e11b2a78808e1c759a78ca1881ea082d 813 SMART SM00316 651 722 3.2E-25 T 09-03-2017 IPR022967 RNA-binding domain, S1 TK78_RS03250 e11b2a78808e1c759a78ca1881ea082d 813 Gene3D G3DSA:1.10.10.650 3 109 1.9E-43 T 09-03-2017 IPR023319 Tex-like protein, HTH domain TK78_RS03250 e11b2a78808e1c759a78ca1881ea082d 813 Gene3D G3DSA:1.10.3500.10 110 323 1.0E-99 T 09-03-2017 IPR023323 Tex-like domain TK78_RS03250 e11b2a78808e1c759a78ca1881ea082d 813 Gene3D G3DSA:1.10.3500.10 453 500 1.0E-99 T 09-03-2017 IPR023323 Tex-like domain TK78_RS03250 e11b2a78808e1c759a78ca1881ea082d 813 SMART SM00732 327 426 4.6E-39 T 09-03-2017 IPR006641 YqgF/RNase H-like domain GO:0006139 TK78_RS03250 e11b2a78808e1c759a78ca1881ea082d 813 Gene3D G3DSA:2.40.50.140 641 722 1.5E-26 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS03250 e11b2a78808e1c759a78ca1881ea082d 813 Gene3D G3DSA:3.30.420.140 327 452 3.5E-51 T 09-03-2017 IPR006641 YqgF/RNase H-like domain GO:0006139 TK78_RS03250 e11b2a78808e1c759a78ca1881ea082d 813 SUPERFAMILY SSF50249 640 724 9.7E-24 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS03250 e11b2a78808e1c759a78ca1881ea082d 813 Gene3D G3DSA:1.10.150.310 501 632 2.3E-42 T 09-03-2017 IPR023097 Tex RuvX-like domain TK78_RS03250 e11b2a78808e1c759a78ca1881ea082d 813 SUPERFAMILY SSF47781 562 633 1.49E-17 T 09-03-2017 IPR010994 RuvA domain 2-like TK78_RS03250 e11b2a78808e1c759a78ca1881ea082d 813 SUPERFAMILY SSF158832 3 322 2.88E-112 T 09-03-2017 TK78_RS30235 8ed13aca0d295f64cfffd6123cf21f91 889 SUPERFAMILY SSF55186 561 720 3.14E-43 T 09-03-2017 IPR018163 Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain GO:0000166 TK78_RS30235 8ed13aca0d295f64cfffd6123cf21f91 889 Hamap MF_00036_B Alanine--tRNA ligase [alaS]. 1 889 168.997 T 09-03-2017 IPR023033 Alanine-tRNA ligase, eukaryota/bacteria GO:0004813 KEGG: 00970+6.1.1.7 TK78_RS30235 8ed13aca0d295f64cfffd6123cf21f91 889 PRINTS PR00980 Alanyl-tRNA synthetase signature 279 295 7.2E-29 T 09-03-2017 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7 TK78_RS30235 8ed13aca0d295f64cfffd6123cf21f91 889 PRINTS PR00980 Alanyl-tRNA synthetase signature 196 207 7.2E-29 T 09-03-2017 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7 TK78_RS30235 8ed13aca0d295f64cfffd6123cf21f91 889 PRINTS PR00980 Alanyl-tRNA synthetase signature 69 80 7.2E-29 T 09-03-2017 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7 TK78_RS30235 8ed13aca0d295f64cfffd6123cf21f91 889 PRINTS PR00980 Alanyl-tRNA synthetase signature 303 316 7.2E-29 T 09-03-2017 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7 TK78_RS30235 8ed13aca0d295f64cfffd6123cf21f91 889 PRINTS PR00980 Alanyl-tRNA synthetase signature 229 242 7.2E-29 T 09-03-2017 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7 TK78_RS30235 8ed13aca0d295f64cfffd6123cf21f91 889 SUPERFAMILY SSF50447 461 561 1.73E-18 T 09-03-2017 IPR009000 Translation protein, beta-barrel domain TK78_RS30235 8ed13aca0d295f64cfffd6123cf21f91 889 TIGRFAM TIGR00344 alaS: alanine--tRNA ligase 5 868 3.4E-261 T 09-03-2017 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7 TK78_RS30235 8ed13aca0d295f64cfffd6123cf21f91 889 SUPERFAMILY SSF101353 249 445 1.44E-58 T 09-03-2017 IPR018162 Alanine-tRNA ligase, class IIc, anti-codon-binding domain GO:0000166|GO:0004813|GO:0005524|GO:0005737|GO:0006419 KEGG: 00970+6.1.1.7 TK78_RS30235 8ed13aca0d295f64cfffd6123cf21f91 889 Gene3D G3DSA:3.30.930.10 1 244 4.2E-96 T 09-03-2017 TK78_RS30235 8ed13aca0d295f64cfffd6123cf21f91 889 Pfam PF02272 DHHA1 domain 813 882 2.8E-11 T 09-03-2017 IPR003156 DHHA1 domain GO:0003676 KEGG: 00970+6.1.1.7|Reactome: R-HSA-379716 TK78_RS30235 8ed13aca0d295f64cfffd6123cf21f91 889 SMART SM00863 662 705 2.3E-21 T 09-03-2017 IPR012947 Threonyl/alanyl tRNA synthetase, SAD GO:0005524|GO:0016876|GO:0043039 TK78_RS30235 8ed13aca0d295f64cfffd6123cf21f91 889 Pfam PF01411 tRNA synthetases class II (A) 5 564 4.7E-194 T 09-03-2017 IPR018164 Alanyl-tRNA synthetase, class IIc, N-terminal GO:0000166|GO:0004813|GO:0005524|GO:0006419 KEGG: 00970+6.1.1.7 TK78_RS30235 8ed13aca0d295f64cfffd6123cf21f91 889 SUPERFAMILY SSF55681 2 248 1.37E-91 T 09-03-2017 TK78_RS30235 8ed13aca0d295f64cfffd6123cf21f91 889 Pfam PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 662 705 3.8E-18 T 09-03-2017 IPR012947 Threonyl/alanyl tRNA synthetase, SAD GO:0005524|GO:0016876|GO:0043039 TK78_RS19655 370af91dbda3fa75db3dcde898d1a305 203 ProSitePatterns PS00794 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. 124 135 - T 09-03-2017 IPR000550 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK GO:0003848|GO:0009396 KEGG: 00790+2.7.6.3|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539 TK78_RS19655 370af91dbda3fa75db3dcde898d1a305 203 TIGRFAM TIGR01498 folK: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase 38 169 1.4E-42 T 09-03-2017 IPR000550 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK GO:0003848|GO:0009396 KEGG: 00790+2.7.6.3|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539 TK78_RS19655 370af91dbda3fa75db3dcde898d1a305 203 Pfam PF01288 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) 39 169 2.2E-37 T 09-03-2017 IPR000550 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK GO:0003848|GO:0009396 KEGG: 00790+2.7.6.3|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539 TK78_RS19655 370af91dbda3fa75db3dcde898d1a305 203 Gene3D G3DSA:3.30.70.560 37 189 2.2E-55 T 09-03-2017 IPR000550 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK GO:0003848|GO:0009396 KEGG: 00790+2.7.6.3|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539 TK78_RS19655 370af91dbda3fa75db3dcde898d1a305 203 SUPERFAMILY SSF55083 37 189 1.44E-49 T 09-03-2017 IPR000550 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK GO:0003848|GO:0009396 KEGG: 00790+2.7.6.3|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539 TK78_RS18080 864441199be243164ff0d906fddac8d6 414 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 57 148 2.1E-14 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS18080 864441199be243164ff0d906fddac8d6 414 SUPERFAMILY SSF47203 287 407 1.32E-22 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS18080 864441199be243164ff0d906fddac8d6 414 Gene3D G3DSA:1.20.140.10 260 408 5.3E-24 T 09-03-2017 TK78_RS18080 864441199be243164ff0d906fddac8d6 414 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 286 403 3.1E-16 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS18080 864441199be243164ff0d906fddac8d6 414 Gene3D G3DSA:2.40.110.10 153 259 7.1E-23 T 09-03-2017 TK78_RS18080 864441199be243164ff0d906fddac8d6 414 Gene3D G3DSA:1.10.540.10 55 150 1.3E-19 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS18080 864441199be243164ff0d906fddac8d6 414 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 154 258 3.7E-15 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS18080 864441199be243164ff0d906fddac8d6 414 PIRSF PIRSF016578 32 397 2.7E-13 T 09-03-2017 TK78_RS18080 864441199be243164ff0d906fddac8d6 414 SUPERFAMILY SSF56645 55 269 7.46E-49 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS24855 65a763ad3b408b1629e5752068da112d 358 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 174 190 5.4E-27 T 09-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 TK78_RS24855 65a763ad3b408b1629e5752068da112d 358 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 138 158 5.4E-27 T 09-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 TK78_RS24855 65a763ad3b408b1629e5752068da112d 358 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 276 292 5.4E-27 T 09-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 TK78_RS24855 65a763ad3b408b1629e5752068da112d 358 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 195 206 5.4E-27 T 09-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 TK78_RS24855 65a763ad3b408b1629e5752068da112d 358 Pfam PF02868 Thermolysin metallopeptidase, alpha-helical domain 186 354 7.8E-52 T 09-03-2017 IPR001570 Peptidase M4, C-terminal GO:0004222 TK78_RS24855 65a763ad3b408b1629e5752068da112d 358 Gene3D G3DSA:1.10.390.10 188 354 5.0E-52 T 09-03-2017 TK78_RS24855 65a763ad3b408b1629e5752068da112d 358 Pfam PF01447 Thermolysin metallopeptidase, catalytic domain 99 183 5.9E-25 T 09-03-2017 IPR013856 Peptidase M4 domain GO:0004222 TK78_RS24855 65a763ad3b408b1629e5752068da112d 358 SUPERFAMILY SSF55486 77 354 6.04E-80 T 09-03-2017 TK78_RS24855 65a763ad3b408b1629e5752068da112d 358 Gene3D G3DSA:3.10.170.10 70 187 3.6E-40 T 09-03-2017 IPR013856 Peptidase M4 domain GO:0004222 TK78_RS25755 39fd0168befceac0dd0edee53d4e4282 709 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 25 503 4.7E-82 T 09-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 TK78_RS25755 39fd0168befceac0dd0edee53d4e4282 709 Pfam PF07690 Major Facilitator Superfamily 30 422 9.9E-55 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS25755 39fd0168befceac0dd0edee53d4e4282 709 PRINTS PR01036 Tetracycline resistance protein TetB signature 149 173 4.1E-8 T 09-03-2017 TK78_RS25755 39fd0168befceac0dd0edee53d4e4282 709 PRINTS PR01036 Tetracycline resistance protein TetB signature 29 53 4.1E-8 T 09-03-2017 TK78_RS25755 39fd0168befceac0dd0edee53d4e4282 709 PRINTS PR01036 Tetracycline resistance protein TetB signature 119 139 4.1E-8 T 09-03-2017 TK78_RS25755 39fd0168befceac0dd0edee53d4e4282 709 PRINTS PR01036 Tetracycline resistance protein TetB signature 413 432 4.1E-8 T 09-03-2017 TK78_RS25755 39fd0168befceac0dd0edee53d4e4282 709 PRINTS PR01036 Tetracycline resistance protein TetB signature 371 391 4.1E-8 T 09-03-2017 TK78_RS25755 39fd0168befceac0dd0edee53d4e4282 709 SUPERFAMILY SSF103473 260 432 1.44E-72 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS25755 39fd0168befceac0dd0edee53d4e4282 709 SUPERFAMILY SSF103473 1 207 1.44E-72 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS25755 39fd0168befceac0dd0edee53d4e4282 709 SUPERFAMILY SSF103473 480 505 1.44E-72 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS25755 39fd0168befceac0dd0edee53d4e4282 709 SUPERFAMILY SSF46785 558 659 1.47E-5 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS25755 39fd0168befceac0dd0edee53d4e4282 709 Gene3D G3DSA:1.20.1250.20 27 207 1.3E-35 T 09-03-2017 TK78_RS25755 39fd0168befceac0dd0edee53d4e4282 709 Gene3D G3DSA:1.20.1250.20 277 430 4.1E-20 T 09-03-2017 TK78_RS25755 39fd0168befceac0dd0edee53d4e4282 709 Gene3D G3DSA:1.20.1250.20 478 508 4.1E-20 T 09-03-2017 TK78_RS25755 39fd0168befceac0dd0edee53d4e4282 709 Gene3D G3DSA:1.10.10.10 547 659 3.9E-5 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32685 3e04a63340cb07c821f133015e23ca5d 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 93 104 5.8E-5 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS32685 3e04a63340cb07c821f133015e23ca5d 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 17 34 5.8E-5 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS32685 3e04a63340cb07c821f133015e23ca5d 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 141 157 5.8E-5 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS32685 3e04a63340cb07c821f133015e23ca5d 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 167 186 5.8E-5 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS32685 3e04a63340cb07c821f133015e23ca5d 255 Gene3D G3DSA:3.40.50.720 14 252 2.4E-35 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS32685 3e04a63340cb07c821f133015e23ca5d 255 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 154 182 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS32685 3e04a63340cb07c821f133015e23ca5d 255 SUPERFAMILY SSF51735 13 251 1.45E-33 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS32685 3e04a63340cb07c821f133015e23ca5d 255 Pfam PF00106 short chain dehydrogenase 17 186 3.0E-23 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS14860 0569c0937f9bf085c8a09b008e3c73f8 347 SUPERFAMILY SSF47413 9 67 4.82E-16 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS14860 0569c0937f9bf085c8a09b008e3c73f8 347 Gene3D G3DSA:3.40.50.2300 60 189 6.0E-29 T 09-03-2017 TK78_RS14860 0569c0937f9bf085c8a09b008e3c73f8 347 Pfam PF00356 Bacterial regulatory proteins, lacI family 11 56 1.4E-14 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS14860 0569c0937f9bf085c8a09b008e3c73f8 347 SUPERFAMILY SSF53822 82 346 1.63E-58 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS14860 0569c0937f9bf085c8a09b008e3c73f8 347 SMART SM00354 9 79 1.2E-20 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS14860 0569c0937f9bf085c8a09b008e3c73f8 347 Gene3D G3DSA:1.10.260.40 9 59 1.4E-20 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS14860 0569c0937f9bf085c8a09b008e3c73f8 347 Gene3D G3DSA:3.40.50.2300 190 323 5.0E-47 T 09-03-2017 TK78_RS14860 0569c0937f9bf085c8a09b008e3c73f8 347 Pfam PF13377 Periplasmic binding protein-like domain 185 346 6.2E-32 T 09-03-2017 TK78_RS04475 1a5e7e046714bf607eda6e5bcc99f6ad 1141 Pfam PF07705 CARDB 443 543 2.3E-14 T 09-03-2017 IPR011635 CARDB domain TK78_RS04475 1a5e7e046714bf607eda6e5bcc99f6ad 1141 Pfam PF07705 CARDB 331 429 4.4E-20 T 09-03-2017 IPR011635 CARDB domain TK78_RS04475 1a5e7e046714bf607eda6e5bcc99f6ad 1141 SMART SM00710 921 943 22.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS04475 1a5e7e046714bf607eda6e5bcc99f6ad 1141 SMART SM00710 830 861 4100.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS04475 1a5e7e046714bf607eda6e5bcc99f6ad 1141 SMART SM00710 979 1002 140.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS04475 1a5e7e046714bf607eda6e5bcc99f6ad 1141 SMART SM00710 955 978 98.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS04475 1a5e7e046714bf607eda6e5bcc99f6ad 1141 SMART SM00710 897 919 71.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS04475 1a5e7e046714bf607eda6e5bcc99f6ad 1141 SMART SM00710 864 885 1200.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS04475 1a5e7e046714bf607eda6e5bcc99f6ad 1141 SMART SM00710 1073 1096 630.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS04475 1a5e7e046714bf607eda6e5bcc99f6ad 1141 SMART SM00710 1046 1068 1.9 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS04475 1a5e7e046714bf607eda6e5bcc99f6ad 1141 SUPERFAMILY SSF51126 709 1084 1.81E-39 T 09-03-2017 IPR011050 Pectin lyase fold/virulence factor TK78_RS04475 1a5e7e046714bf607eda6e5bcc99f6ad 1141 Gene3D G3DSA:2.60.120.260 30 176 4.6E-30 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS04475 1a5e7e046714bf607eda6e5bcc99f6ad 1141 Gene3D G3DSA:2.60.120.260 186 330 3.0E-19 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS04475 1a5e7e046714bf607eda6e5bcc99f6ad 1141 SUPERFAMILY SSF49785 187 325 1.91E-16 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS04475 1a5e7e046714bf607eda6e5bcc99f6ad 1141 Pfam PF00754 F5/8 type C domain 198 321 1.9E-10 T 09-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain TK78_RS04475 1a5e7e046714bf607eda6e5bcc99f6ad 1141 Pfam PF00754 F5/8 type C domain 45 165 3.0E-17 T 09-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain TK78_RS04475 1a5e7e046714bf607eda6e5bcc99f6ad 1141 Gene3D G3DSA:2.160.20.10 709 1111 1.7E-28 T 09-03-2017 IPR012334 Pectin lyase fold TK78_RS04475 1a5e7e046714bf607eda6e5bcc99f6ad 1141 Pfam PF13229 Right handed beta helix region 897 1020 3.6E-7 T 09-03-2017 TK78_RS04475 1a5e7e046714bf607eda6e5bcc99f6ad 1141 SUPERFAMILY SSF49785 37 171 2.91E-25 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS20995 497f24ec4a5a9b465c0fade9911548d6 213 SUPERFAMILY SSF46955 2 72 1.28E-17 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS20995 497f24ec4a5a9b465c0fade9911548d6 213 Gene3D G3DSA:1.10.1660.10 2 73 3.6E-19 T 09-03-2017 TK78_RS20995 497f24ec4a5a9b465c0fade9911548d6 213 Pfam PF13411 MerR HTH family regulatory protein 1 63 7.0E-19 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS20995 497f24ec4a5a9b465c0fade9911548d6 213 SMART SM00422 3 67 2.5E-11 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS10180 083b72f0f5f064bfe461e31ac561455b 217 ProDom PD016028 PROTEASE METALLOPROTEASE EXTRACELLULAR NEUTRAL SMALL METAL-BINDING ZINC HYDROLASE SNAPALYSIN ZYMOGEN 85 208 4.0E-60 T 09-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 TK78_RS10180 083b72f0f5f064bfe461e31ac561455b 217 PRINTS PR00787 Streptomyces extracellular neutral proteinase (M7) family signature 84 110 4.5E-64 T 09-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 TK78_RS10180 083b72f0f5f064bfe461e31ac561455b 217 PRINTS PR00787 Streptomyces extracellular neutral proteinase (M7) family signature 141 165 4.5E-64 T 09-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 TK78_RS10180 083b72f0f5f064bfe461e31ac561455b 217 PRINTS PR00787 Streptomyces extracellular neutral proteinase (M7) family signature 166 190 4.5E-64 T 09-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 TK78_RS10180 083b72f0f5f064bfe461e31ac561455b 217 PRINTS PR00787 Streptomyces extracellular neutral proteinase (M7) family signature 116 140 4.5E-64 T 09-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 TK78_RS10180 083b72f0f5f064bfe461e31ac561455b 217 PRINTS PR00787 Streptomyces extracellular neutral proteinase (M7) family signature 193 207 4.5E-64 T 09-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 TK78_RS10180 083b72f0f5f064bfe461e31ac561455b 217 SUPERFAMILY SSF55486 78 206 7.56E-32 T 09-03-2017 TK78_RS10180 083b72f0f5f064bfe461e31ac561455b 217 PIRSF PIRSF016573 1 217 2.6E-110 T 09-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 TK78_RS10180 083b72f0f5f064bfe461e31ac561455b 217 Gene3D G3DSA:3.40.390.10 79 206 8.8E-39 T 09-03-2017 IPR024079 Metallopeptidase, catalytic domain GO:0008237 TK78_RS10180 083b72f0f5f064bfe461e31ac561455b 217 Pfam PF02031 Streptomyces extracellular neutral proteinase (M7) family 77 208 2.7E-82 T 09-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 TK78_RS19340 4c728c421fe5de2f8426e88eda735ae7 215 Gene3D G3DSA:2.40.260.10 93 181 1.4E-9 T 09-03-2017 IPR023365 Sortase domain TK78_RS19340 4c728c421fe5de2f8426e88eda735ae7 215 SUPERFAMILY SSF63817 44 182 7.32E-12 T 09-03-2017 IPR023365 Sortase domain TK78_RS19340 4c728c421fe5de2f8426e88eda735ae7 215 Pfam PF04203 Sortase family 53 184 1.1E-11 T 09-03-2017 IPR005754 Sortase family TK78_RS17985 1479fbcc6c75aaf8df517121fa363fd5 369 Gene3D G3DSA:3.30.2110.10 21 193 2.0E-56 T 09-03-2017 TK78_RS17985 1479fbcc6c75aaf8df517121fa363fd5 369 Hamap MF_00787 Cobalt-precorrin-5B C(1)-methyltransferase [cbiD]. 18 369 27.117 T 09-03-2017 IPR002748 Cobalt-precorrin-5B C(1)-methyltransferase CbiD GO:0008168|GO:0009236 KEGG: 00670+2.1.1.19|KEGG: 00860+2.1.1.195|MetaCyc: PWY-2201|MetaCyc: PWY-7377 TK78_RS17985 1479fbcc6c75aaf8df517121fa363fd5 369 TIGRFAM TIGR00312 cbiD: cobalamin biosynthesis protein CbiD 25 329 1.1E-49 T 09-03-2017 IPR002748 Cobalt-precorrin-5B C(1)-methyltransferase CbiD GO:0008168|GO:0009236 KEGG: 00670+2.1.1.19|KEGG: 00860+2.1.1.195|MetaCyc: PWY-2201|MetaCyc: PWY-7377 TK78_RS17985 1479fbcc6c75aaf8df517121fa363fd5 369 PIRSF PIRSF026782 14 369 6.3E-122 T 09-03-2017 IPR002748 Cobalt-precorrin-5B C(1)-methyltransferase CbiD GO:0008168|GO:0009236 KEGG: 00670+2.1.1.19|KEGG: 00860+2.1.1.195|MetaCyc: PWY-2201|MetaCyc: PWY-7377 TK78_RS17985 1479fbcc6c75aaf8df517121fa363fd5 369 SUPERFAMILY SSF111342 13 295 8.5E-80 T 09-03-2017 IPR002748 Cobalt-precorrin-5B C(1)-methyltransferase CbiD GO:0008168|GO:0009236 KEGG: 00670+2.1.1.19|KEGG: 00860+2.1.1.195|MetaCyc: PWY-2201|MetaCyc: PWY-7377 TK78_RS17985 1479fbcc6c75aaf8df517121fa363fd5 369 Pfam PF01888 CbiD 18 278 1.8E-85 T 09-03-2017 IPR002748 Cobalt-precorrin-5B C(1)-methyltransferase CbiD GO:0008168|GO:0009236 KEGG: 00670+2.1.1.19|KEGG: 00860+2.1.1.195|MetaCyc: PWY-2201|MetaCyc: PWY-7377 TK78_RS02145 512e256a6a472c3f816b8a14cf76ae25 251 Hamap MF_02036 Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase [egtC]. 1 246 40.3 T 09-03-2017 IPR032889 Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase, Actinobacteria GO:0016811|GO:0052699 KEGG: 00311+3.5.1.11|KEGG: 00340+3.5.1.118|MetaCyc: PWY-7255 TK78_RS02145 512e256a6a472c3f816b8a14cf76ae25 251 SUPERFAMILY SSF56235 2 239 1.57E-14 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS02145 512e256a6a472c3f816b8a14cf76ae25 251 Gene3D G3DSA:3.60.20.10 1 245 1.5E-40 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS02145 512e256a6a472c3f816b8a14cf76ae25 251 Pfam PF13522 Glutamine amidotransferase domain 71 217 8.6E-19 T 09-03-2017 TK78_RS02145 512e256a6a472c3f816b8a14cf76ae25 251 TIGRFAM TIGR03442 TIGR03442: ergothioneine biosynthesis protein EgtC 1 246 1.8E-86 T 09-03-2017 IPR017808 Ergothioneine biosynthesis protein EgtC GO:0052699 TK78_RS08100 36066ab226bcdf686743e923e9a25837 278 Pfam PF04542 Sigma-70 region 2 48 120 2.9E-16 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS08100 36066ab226bcdf686743e923e9a25837 278 ProSitePatterns PS00716 Sigma-70 factors family signature 2. 243 269 - T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS08100 36066ab226bcdf686743e923e9a25837 278 SUPERFAMILY SSF88659 187 275 1.87E-24 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS08100 36066ab226bcdf686743e923e9a25837 278 Gene3D G3DSA:1.10.10.10 211 275 5.8E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS08100 36066ab226bcdf686743e923e9a25837 278 SUPERFAMILY SSF88946 18 120 4.55E-26 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS08100 36066ab226bcdf686743e923e9a25837 278 PRINTS PR00046 Major sigma-70 factor signature 226 238 5.6E-12 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS08100 36066ab226bcdf686743e923e9a25837 278 PRINTS PR00046 Major sigma-70 factor signature 258 269 5.6E-12 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS08100 36066ab226bcdf686743e923e9a25837 278 PRINTS PR00046 Major sigma-70 factor signature 75 88 5.6E-12 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS08100 36066ab226bcdf686743e923e9a25837 278 PRINTS PR00046 Major sigma-70 factor signature 243 258 5.6E-12 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS08100 36066ab226bcdf686743e923e9a25837 278 Gene3D G3DSA:1.10.10.10 120 165 1.0E-7 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS08100 36066ab226bcdf686743e923e9a25837 278 SUPERFAMILY SSF88659 121 200 4.05E-13 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS08100 36066ab226bcdf686743e923e9a25837 278 PIRSF PIRSF000770 25 278 1.8E-77 T 09-03-2017 IPR016263 RNA polymerase sporulation-specific sigma factor GO:0003677|GO:0006351|GO:0016987|GO:0030435 TK78_RS08100 36066ab226bcdf686743e923e9a25837 278 TIGRFAM TIGR02479 FliA_WhiG: RNA polymerase sigma factor, FliA/WhiG family 48 273 4.0E-87 T 09-03-2017 IPR012845 RNA polymerase sigma factor, FliA/WhiG GO:0003677|GO:0003899|GO:0006352|GO:0006355|GO:0016987 TK78_RS08100 36066ab226bcdf686743e923e9a25837 278 Pfam PF04539 Sigma-70 region 3 128 208 1.0E-6 T 09-03-2017 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS08100 36066ab226bcdf686743e923e9a25837 278 Gene3D G3DSA:1.10.601.10 29 111 9.5E-17 T 09-03-2017 TK78_RS08100 36066ab226bcdf686743e923e9a25837 278 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 44 273 4.1E-36 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS08100 36066ab226bcdf686743e923e9a25837 278 ProSitePatterns PS00715 Sigma-70 factors family signature 1. 75 88 - T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS08100 36066ab226bcdf686743e923e9a25837 278 Pfam PF04545 Sigma-70, region 4 222 271 1.2E-18 T 09-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS22235 d4b8be4d91393eafae2f0386a196807e 568 Gene3D G3DSA:3.30.200.20 5 116 1.3E-22 T 09-03-2017 TK78_RS22235 d4b8be4d91393eafae2f0386a196807e 568 SMART SM00220 8 276 2.0E-74 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS22235 d4b8be4d91393eafae2f0386a196807e 568 Gene3D G3DSA:1.10.510.10 117 271 1.4E-58 T 09-03-2017 TK78_RS22235 d4b8be4d91393eafae2f0386a196807e 568 Gene3D G3DSA:1.10.510.10 379 478 1.4E-58 T 09-03-2017 TK78_RS22235 d4b8be4d91393eafae2f0386a196807e 568 SUPERFAMILY SSF56112 403 482 1.2E-80 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS22235 d4b8be4d91393eafae2f0386a196807e 568 SUPERFAMILY SSF56112 5 276 1.2E-80 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS22235 d4b8be4d91393eafae2f0386a196807e 568 Pfam PF00069 Protein kinase domain 10 269 4.2E-52 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS22235 d4b8be4d91393eafae2f0386a196807e 568 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 138 150 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS01910 1def9cb88d8560c3c5372dca251c067a 121 SUPERFAMILY SSF48452 16 114 1.96E-12 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS01910 1def9cb88d8560c3c5372dca251c067a 121 Pfam PF14559 Tetratricopeptide repeat 24 86 2.7E-8 T 09-03-2017 TK78_RS01910 1def9cb88d8560c3c5372dca251c067a 121 Gene3D G3DSA:1.25.40.10 17 113 6.3E-13 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS04365 898cac3e8b0ee52776bcb390a414ca84 196 SUPERFAMILY SSF46689 20 91 7.48E-15 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS04365 898cac3e8b0ee52776bcb390a414ca84 196 Pfam PF00440 Bacterial regulatory proteins, tetR family 27 70 1.7E-12 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS04365 898cac3e8b0ee52776bcb390a414ca84 196 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 47 70 4.8E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS04365 898cac3e8b0ee52776bcb390a414ca84 196 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 27 40 4.8E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS04365 898cac3e8b0ee52776bcb390a414ca84 196 Gene3D G3DSA:1.10.357.10 19 184 7.4E-26 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS21570 8cc9bcee3f63e511df18f0632cc535d6 234 SUPERFAMILY SSF53955 45 118 8.0E-31 T 09-03-2017 IPR023346 Lysozyme-like domain TK78_RS21570 8cc9bcee3f63e511df18f0632cc535d6 234 Gene3D G3DSA:3.10.350.10 186 233 1.2E-11 T 09-03-2017 IPR018392 LysM domain TK78_RS21570 8cc9bcee3f63e511df18f0632cc535d6 234 SMART SM00257 186 234 1.9E-4 T 09-03-2017 IPR018392 LysM domain TK78_RS21570 8cc9bcee3f63e511df18f0632cc535d6 234 Pfam PF01476 LysM domain 187 233 3.3E-8 T 09-03-2017 IPR018392 LysM domain TK78_RS21570 8cc9bcee3f63e511df18f0632cc535d6 234 Pfam PF06737 Transglycosylase-like domain 42 117 2.5E-33 T 09-03-2017 IPR010618 Transglycosylase-like TK78_RS21570 8cc9bcee3f63e511df18f0632cc535d6 234 SUPERFAMILY SSF54106 186 233 2.88E-6 T 09-03-2017 IPR018392 LysM domain TK78_RS21570 8cc9bcee3f63e511df18f0632cc535d6 234 Gene3D G3DSA:1.10.530.10 20 119 2.5E-40 T 09-03-2017 TK78_RS31275 ce5bb7fbfd29a290694bd7e88c9ef91b 370 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 47 287 9.4E-29 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS31275 ce5bb7fbfd29a290694bd7e88c9ef91b 370 Gene3D G3DSA:3.40.50.1100 145 312 2.1E-23 T 09-03-2017 TK78_RS31275 ce5bb7fbfd29a290694bd7e88c9ef91b 370 SUPERFAMILY SSF53686 46 312 7.82E-44 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS31275 ce5bb7fbfd29a290694bd7e88c9ef91b 370 Gene3D G3DSA:3.40.50.1100 46 144 1.2E-16 T 09-03-2017 TK78_RS32130 c9d4d06bc01ce745a7c6f2ddd5465f9e 763 SMART SM00564 647 679 0.026 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS32130 c9d4d06bc01ce745a7c6f2ddd5465f9e 763 SMART SM00564 444 494 15.0 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS32130 c9d4d06bc01ce745a7c6f2ddd5465f9e 763 SMART SM00564 508 541 290.0 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS32130 c9d4d06bc01ce745a7c6f2ddd5465f9e 763 SMART SM00564 687 719 1.1E-4 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS32130 c9d4d06bc01ce745a7c6f2ddd5465f9e 763 Pfam PF00069 Protein kinase domain 17 260 3.3E-40 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS32130 c9d4d06bc01ce745a7c6f2ddd5465f9e 763 SUPERFAMILY SSF50998 644 757 2.2E-22 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS32130 c9d4d06bc01ce745a7c6f2ddd5465f9e 763 Gene3D G3DSA:3.30.200.20 12 111 3.4E-14 T 09-03-2017 TK78_RS32130 c9d4d06bc01ce745a7c6f2ddd5465f9e 763 Gene3D G3DSA:1.10.510.10 112 314 1.6E-42 T 09-03-2017 TK78_RS32130 c9d4d06bc01ce745a7c6f2ddd5465f9e 763 SMART SM00220 14 263 7.3E-42 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS32130 c9d4d06bc01ce745a7c6f2ddd5465f9e 763 Gene3D G3DSA:2.140.10.10 343 756 1.8E-34 T 09-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain TK78_RS32130 c9d4d06bc01ce745a7c6f2ddd5465f9e 763 SUPERFAMILY SSF56112 12 263 2.56E-61 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS32130 c9d4d06bc01ce745a7c6f2ddd5465f9e 763 SUPERFAMILY SSF50998 394 555 4.32E-16 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS32130 c9d4d06bc01ce745a7c6f2ddd5465f9e 763 SUPERFAMILY SSF50998 596 756 4.32E-16 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS32130 c9d4d06bc01ce745a7c6f2ddd5465f9e 763 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 132 144 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS32130 c9d4d06bc01ce745a7c6f2ddd5465f9e 763 Pfam PF13360 PQQ-like domain 477 718 1.5E-20 T 09-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat TK78_RS32130 c9d4d06bc01ce745a7c6f2ddd5465f9e 763 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 20 42 - T 09-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 TK78_RS27465 e6f92c39c3cff5db3e099b56a3967a83 67 SMART SM00357 3 67 7.2E-32 T 09-03-2017 IPR011129 Cold shock protein GO:0003676 TK78_RS27465 e6f92c39c3cff5db3e099b56a3967a83 67 PRINTS PR00050 Cold shock protein signature 40 58 6.9E-18 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS27465 e6f92c39c3cff5db3e099b56a3967a83 67 PRINTS PR00050 Cold shock protein signature 4 19 6.9E-18 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS27465 e6f92c39c3cff5db3e099b56a3967a83 67 PRINTS PR00050 Cold shock protein signature 25 34 6.9E-18 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS27465 e6f92c39c3cff5db3e099b56a3967a83 67 Pfam PF00313 'Cold-shock' DNA-binding domain 3 65 1.8E-31 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS27465 e6f92c39c3cff5db3e099b56a3967a83 67 Gene3D G3DSA:2.40.50.140 1 65 4.8E-31 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS27465 e6f92c39c3cff5db3e099b56a3967a83 67 SUPERFAMILY SSF50249 1 66 3.43E-25 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS27465 e6f92c39c3cff5db3e099b56a3967a83 67 PIRSF PIRSF002599 1 67 1.9E-26 T 09-03-2017 IPR012156 Cold shock, CspA GO:0003676 TK78_RS27465 e6f92c39c3cff5db3e099b56a3967a83 67 ProSitePatterns PS00352 'Cold-shock' domain signature. 15 34 - T 09-03-2017 IPR019844 Cold-shock conserved site TK78_RS29080 32984e7c6d15aca1c1a1ba7659308c14 561 Gene3D G3DSA:2.30.38.10 385 458 1.4E-26 T 09-03-2017 TK78_RS29080 32984e7c6d15aca1c1a1ba7659308c14 561 Gene3D G3DSA:3.30.300.30 462 559 1.9E-34 T 09-03-2017 TK78_RS29080 32984e7c6d15aca1c1a1ba7659308c14 561 ProSitePatterns PS00455 Putative AMP-binding domain signature. 216 227 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS29080 32984e7c6d15aca1c1a1ba7659308c14 561 Pfam PF13193 AMP-binding enzyme C-terminal domain 476 551 7.9E-23 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS29080 32984e7c6d15aca1c1a1ba7659308c14 561 Gene3D G3DSA:3.40.50.980 34 146 5.5E-39 T 09-03-2017 TK78_RS29080 32984e7c6d15aca1c1a1ba7659308c14 561 Gene3D G3DSA:3.40.50.980 201 225 5.5E-39 T 09-03-2017 TK78_RS29080 32984e7c6d15aca1c1a1ba7659308c14 561 Pfam PF00501 AMP-binding enzyme 40 466 2.0E-99 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS29080 32984e7c6d15aca1c1a1ba7659308c14 561 Gene3D G3DSA:3.40.50.980 226 378 4.0E-38 T 09-03-2017 TK78_RS29080 32984e7c6d15aca1c1a1ba7659308c14 561 SUPERFAMILY SSF56801 20 560 4.71E-156 T 09-03-2017 TK78_RS13135 222e216320bb7dbb0ef0e701405c8d04 276 SUPERFAMILY SSF54814 2 105 1.15E-34 T 09-03-2017 IPR009019 K homology domain, prokaryotic type GO:0003723 TK78_RS13135 222e216320bb7dbb0ef0e701405c8d04 276 ProSitePatterns PS00548 Ribosomal protein S3 signature. 162 196 - T 09-03-2017 IPR018280 Ribosomal protein S3, conserved site Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13135 222e216320bb7dbb0ef0e701405c8d04 276 SMART SM00322 59 124 4.4E-7 T 09-03-2017 IPR004087 K Homology domain GO:0003676 TK78_RS13135 222e216320bb7dbb0ef0e701405c8d04 276 TIGRFAM TIGR01009 rpsC_bact: ribosomal protein uS3 1 207 5.6E-93 T 09-03-2017 IPR005704 Ribosomal protein S3, bacterial GO:0003735|GO:0006412|GO:0015935 TK78_RS13135 222e216320bb7dbb0ef0e701405c8d04 276 Gene3D G3DSA:3.30.1140.32 107 206 2.5E-42 T 09-03-2017 IPR001351 Ribosomal protein S3, C-terminal GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13135 222e216320bb7dbb0ef0e701405c8d04 276 SUPERFAMILY SSF54821 106 205 1.07E-37 T 09-03-2017 IPR001351 Ribosomal protein S3, C-terminal GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13135 222e216320bb7dbb0ef0e701405c8d04 276 Pfam PF07650 KH domain 38 109 4.7E-19 T 09-03-2017 IPR004044 K Homology domain, type 2 GO:0003723 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13135 222e216320bb7dbb0ef0e701405c8d04 276 Hamap MF_01309_B 30S ribosomal protein S3 [rpsC]. 1 205 37.884 T 09-03-2017 IPR005704 Ribosomal protein S3, bacterial GO:0003735|GO:0006412|GO:0015935 TK78_RS13135 222e216320bb7dbb0ef0e701405c8d04 276 Gene3D G3DSA:3.30.300.20 17 106 1.7E-31 T 09-03-2017 IPR015946 K homology domain-like, alpha/beta TK78_RS13135 222e216320bb7dbb0ef0e701405c8d04 276 Pfam PF00189 Ribosomal protein S3, C-terminal domain 119 201 1.0E-36 T 09-03-2017 TK78_RS24760 3b4021409c47c28cadf5e48039fdca64 243 SUPERFAMILY SSF56281 5 239 5.46E-37 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS24760 3b4021409c47c28cadf5e48039fdca64 243 Pfam PF00753 Metallo-beta-lactamase superfamily 27 220 7.5E-15 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS24760 3b4021409c47c28cadf5e48039fdca64 243 SMART SM00849 26 220 3.9E-15 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS24760 3b4021409c47c28cadf5e48039fdca64 243 Gene3D G3DSA:3.60.15.10 8 239 1.3E-43 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS22100 8f24b92a3718b1c8e0abcf66cd0c0ad9 259 Gene3D G3DSA:3.40.50.2020 117 227 5.2E-12 T 09-03-2017 IPR029057 Phosphoribosyltransferase-like TK78_RS22100 8f24b92a3718b1c8e0abcf66cd0c0ad9 259 SUPERFAMILY SSF53271 140 226 1.1E-10 T 09-03-2017 IPR029057 Phosphoribosyltransferase-like TK78_RS20880 b2fe0433935c5a4f3fb5f936667662ed 547 Pfam PF00999 Sodium/hydrogen exchanger family 15 385 9.8E-49 T 09-03-2017 IPR006153 Cation/H+ exchanger GO:0006812|GO:0015299|GO:0016021|GO:0055085 TK78_RS20880 b2fe0433935c5a4f3fb5f936667662ed 547 Pfam PF02080 TrkA-C domain 415 473 1.4E-11 T 09-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 TK78_RS20880 b2fe0433935c5a4f3fb5f936667662ed 547 SUPERFAMILY SSF116726 410 480 3.27E-11 T 09-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 TK78_RS20880 b2fe0433935c5a4f3fb5f936667662ed 547 Gene3D G3DSA:3.30.70.1450 412 478 2.3E-9 T 09-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 TK78_RS31510 23588b12f1a04508afb900b37f35d16b 282 Gene3D G3DSA:3.40.50.1110 9 194 6.9E-35 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS31510 23588b12f1a04508afb900b37f35d16b 282 SUPERFAMILY SSF52266 8 192 8.16E-36 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS31510 23588b12f1a04508afb900b37f35d16b 282 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 12 183 7.8E-23 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS28680 96d9d4506b57ba9fac651b44fae9049e 359 SUPERFAMILY SSF52374 7 152 8.0E-12 T 09-03-2017 TK78_RS28680 96d9d4506b57ba9fac651b44fae9049e 359 Pfam PF13521 AAA domain 156 333 2.0E-31 T 09-03-2017 TK78_RS28680 96d9d4506b57ba9fac651b44fae9049e 359 SUPERFAMILY SSF52540 155 341 4.07E-11 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28680 96d9d4506b57ba9fac651b44fae9049e 359 Gene3D G3DSA:3.40.50.300 163 338 7.3E-48 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28680 96d9d4506b57ba9fac651b44fae9049e 359 TIGRFAM TIGR00125 cyt_tran_rel: cytidyltransferase-like domain 7 42 3.8E-7 T 09-03-2017 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 TK78_RS28680 96d9d4506b57ba9fac651b44fae9049e 359 Gene3D G3DSA:3.40.50.620 3 162 1.4E-29 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS08590 d7467dd0e4e2cef5f7c3ad2ce3db97c4 291 SMART SM00871 127 286 1.3E-25 T 09-03-2017 IPR010499 Bacterial transcription activator, effector binding TK78_RS08590 d7467dd0e4e2cef5f7c3ad2ce3db97c4 291 Gene3D G3DSA:1.10.10.60 56 114 4.3E-11 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS08590 d7467dd0e4e2cef5f7c3ad2ce3db97c4 291 SMART SM00342 19 103 1.3E-15 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS08590 d7467dd0e4e2cef5f7c3ad2ce3db97c4 291 Pfam PF12833 Helix-turn-helix domain 25 104 6.9E-15 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS08590 d7467dd0e4e2cef5f7c3ad2ce3db97c4 291 Gene3D G3DSA:3.20.80.10 115 286 8.0E-24 T 09-03-2017 IPR011256 Regulatory factor, effector binding domain TK78_RS08590 d7467dd0e4e2cef5f7c3ad2ce3db97c4 291 SUPERFAMILY SSF46689 62 106 1.66E-6 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS08590 d7467dd0e4e2cef5f7c3ad2ce3db97c4 291 SUPERFAMILY SSF55136 127 286 1.15E-20 T 09-03-2017 IPR011256 Regulatory factor, effector binding domain TK78_RS08590 d7467dd0e4e2cef5f7c3ad2ce3db97c4 291 Pfam PF06445 GyrI-like small molecule binding domain 127 285 1.0E-22 T 09-03-2017 IPR029442 GyrI-like small molecule binding domain TK78_RS08590 d7467dd0e4e2cef5f7c3ad2ce3db97c4 291 Gene3D G3DSA:1.10.10.60 3 55 5.5E-16 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS08590 d7467dd0e4e2cef5f7c3ad2ce3db97c4 291 SUPERFAMILY SSF46689 3 53 8.96E-8 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS25605 2d67a5b6013d4a6977362ce85b858f3a 152 Pfam PF00578 AhpC/TSA family 5 130 7.5E-41 T 09-03-2017 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15|Reactome: R-HSA-3299685 TK78_RS25605 2d67a5b6013d4a6977362ce85b858f3a 152 Gene3D G3DSA:3.40.30.10 2 152 2.1E-50 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS25605 2d67a5b6013d4a6977362ce85b858f3a 152 SUPERFAMILY SSF52833 1 152 9.68E-50 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS25605 2d67a5b6013d4a6977362ce85b858f3a 152 PIRSF PIRSF000239 1 152 2.0E-29 T 09-03-2017 IPR024706 Peroxiredoxin, AhpC-type KEGG: 00480+1.11.1.15|Reactome: R-HSA-3299685 TK78_RS16285 3f1d46f1d16f5324971c25b284992b53 439 Pfam PF00512 His Kinase A (phospho-acceptor) domain 238 295 3.4E-12 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS16285 3f1d46f1d16f5324971c25b284992b53 439 SMART SM00387 333 436 6.0E-20 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS16285 3f1d46f1d16f5324971c25b284992b53 439 SMART SM00388 236 295 5.8E-13 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS16285 3f1d46f1d16f5324971c25b284992b53 439 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 333 432 2.7E-14 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS16285 3f1d46f1d16f5324971c25b284992b53 439 Pfam PF00672 HAMP domain 164 232 5.1E-10 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS16285 3f1d46f1d16f5324971c25b284992b53 439 SMART SM00304 181 235 3.2E-6 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS16285 3f1d46f1d16f5324971c25b284992b53 439 SUPERFAMILY SSF158472 184 232 6.8E-6 T 09-03-2017 TK78_RS16285 3f1d46f1d16f5324971c25b284992b53 439 SUPERFAMILY SSF47384 220 295 1.02E-13 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS16285 3f1d46f1d16f5324971c25b284992b53 439 Gene3D G3DSA:1.10.287.130 226 282 6.9E-14 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS16285 3f1d46f1d16f5324971c25b284992b53 439 SUPERFAMILY SSF55874 284 432 3.67E-25 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS16285 3f1d46f1d16f5324971c25b284992b53 439 PRINTS PR00344 Bacterial sensor protein C-terminal signature 420 433 2.7E-5 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS16285 3f1d46f1d16f5324971c25b284992b53 439 PRINTS PR00344 Bacterial sensor protein C-terminal signature 364 378 2.7E-5 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS16285 3f1d46f1d16f5324971c25b284992b53 439 PRINTS PR00344 Bacterial sensor protein C-terminal signature 396 414 2.7E-5 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS16285 3f1d46f1d16f5324971c25b284992b53 439 Gene3D G3DSA:3.30.565.10 283 433 3.9E-24 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS18630 05e067ae84fbe844a90b898563c61d57 206 SUPERFAMILY SSF109755 42 199 1.07E-5 T 09-03-2017 TK78_RS18630 05e067ae84fbe844a90b898563c61d57 206 Pfam PF01865 Protein of unknown function DUF47 7 203 1.7E-29 T 09-03-2017 IPR018445 Putative phosphate transport regulator TK78_RS00625 fc156005c35e819c4a907e0bfbe1f352 367 SMART SM00388 134 198 8.3E-10 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS00625 fc156005c35e819c4a907e0bfbe1f352 367 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 244 350 2.6E-12 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS00625 fc156005c35e819c4a907e0bfbe1f352 367 SUPERFAMILY SSF55874 189 351 9.82E-29 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS00625 fc156005c35e819c4a907e0bfbe1f352 367 SMART SM00304 80 133 7.1E-11 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS00625 fc156005c35e819c4a907e0bfbe1f352 367 SMART SM00387 240 353 1.4E-21 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS00625 fc156005c35e819c4a907e0bfbe1f352 367 Pfam PF00672 HAMP domain 61 129 1.4E-15 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS00625 fc156005c35e819c4a907e0bfbe1f352 367 SUPERFAMILY SSF47384 117 197 1.29E-13 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS00625 fc156005c35e819c4a907e0bfbe1f352 367 PRINTS PR00344 Bacterial sensor protein C-terminal signature 278 292 2.9E-7 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS00625 fc156005c35e819c4a907e0bfbe1f352 367 PRINTS PR00344 Bacterial sensor protein C-terminal signature 337 350 2.9E-7 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS00625 fc156005c35e819c4a907e0bfbe1f352 367 PRINTS PR00344 Bacterial sensor protein C-terminal signature 313 331 2.9E-7 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS00625 fc156005c35e819c4a907e0bfbe1f352 367 Gene3D G3DSA:1.10.287.130 124 194 1.0E-10 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS00625 fc156005c35e819c4a907e0bfbe1f352 367 Gene3D G3DSA:3.30.565.10 199 351 1.2E-28 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS00625 fc156005c35e819c4a907e0bfbe1f352 367 Pfam PF00512 His Kinase A (phospho-acceptor) domain 135 196 1.2E-9 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS00625 fc156005c35e819c4a907e0bfbe1f352 367 SUPERFAMILY SSF158472 81 130 5.89E-8 T 09-03-2017 TK78_RS18805 1834b0e3d3b35235ed6ac58b2c062b16 246 SUPERFAMILY SSF52172 6 131 9.96E-46 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS18805 1834b0e3d3b35235ed6ac58b2c062b16 246 SMART SM00862 163 238 3.5E-26 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS18805 1834b0e3d3b35235ed6ac58b2c062b16 246 Pfam PF00072 Response regulator receiver domain 11 121 9.7E-33 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS18805 1834b0e3d3b35235ed6ac58b2c062b16 246 SMART SM00448 9 120 1.2E-46 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS18805 1834b0e3d3b35235ed6ac58b2c062b16 246 SUPERFAMILY SSF46894 140 239 6.8E-31 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS18805 1834b0e3d3b35235ed6ac58b2c062b16 246 Gene3D G3DSA:3.40.50.2300 6 129 1.4E-43 T 09-03-2017 TK78_RS18805 1834b0e3d3b35235ed6ac58b2c062b16 246 Gene3D G3DSA:1.10.10.10 140 239 3.6E-35 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS18805 1834b0e3d3b35235ed6ac58b2c062b16 246 Pfam PF00486 Transcriptional regulatory protein, C terminal 164 238 3.2E-26 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS11365 70bf946bf8c610d47253628968378daa 81 TIGRFAM TIGR01280 xseB: exodeoxyribonuclease VII, small subunit 18 71 6.7E-20 T 09-03-2017 IPR003761 Exonuclease VII, small subunit GO:0006308|GO:0008855|GO:0009318 TK78_RS11365 70bf946bf8c610d47253628968378daa 81 Hamap MF_00337 Exodeoxyribonuclease 7 small subunit [xseB]. 17 77 13.525 T 09-03-2017 IPR003761 Exonuclease VII, small subunit GO:0006308|GO:0008855|GO:0009318 TK78_RS11365 70bf946bf8c610d47253628968378daa 81 PIRSF PIRSF006488 6 81 9.3E-24 T 09-03-2017 IPR003761 Exonuclease VII, small subunit GO:0006308|GO:0008855|GO:0009318 TK78_RS11365 70bf946bf8c610d47253628968378daa 81 Pfam PF02609 Exonuclease VII small subunit 18 67 1.4E-17 T 09-03-2017 IPR003761 Exonuclease VII, small subunit GO:0006308|GO:0008855|GO:0009318 TK78_RS11365 70bf946bf8c610d47253628968378daa 81 ProDom PD028235 EXONUCLEASE SMALL SUBUNIT VII EXODEOXYRIBONUCLEASE HYDROLASE NUCLEASE PROBABLE VII SIMILAR 16 56 7.0E-15 T 09-03-2017 IPR003761 Exonuclease VII, small subunit GO:0006308|GO:0008855|GO:0009318 TK78_RS11365 70bf946bf8c610d47253628968378daa 81 Gene3D G3DSA:1.10.287.1040 15 74 1.0E-21 T 09-03-2017 IPR003761 Exonuclease VII, small subunit GO:0006308|GO:0008855|GO:0009318 TK78_RS11365 70bf946bf8c610d47253628968378daa 81 SUPERFAMILY SSF116842 12 72 4.18E-16 T 09-03-2017 TK78_RS05290 6ad855016bed5b451d9c63bcc0d62674 268 Pfam PF07729 FCD domain 140 264 9.8E-18 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS05290 6ad855016bed5b451d9c63bcc0d62674 268 SMART SM00345 72 130 1.1E-11 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS05290 6ad855016bed5b451d9c63bcc0d62674 268 SUPERFAMILY SSF48008 136 265 4.71E-18 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS05290 6ad855016bed5b451d9c63bcc0d62674 268 Gene3D G3DSA:1.10.10.10 54 131 2.5E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05290 6ad855016bed5b451d9c63bcc0d62674 268 Pfam PF00392 Bacterial regulatory proteins, gntR family 71 130 3.1E-15 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS05290 6ad855016bed5b451d9c63bcc0d62674 268 SMART SM00895 140 265 3.9E-11 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS05290 6ad855016bed5b451d9c63bcc0d62674 268 SUPERFAMILY SSF46785 64 134 6.1E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05290 6ad855016bed5b451d9c63bcc0d62674 268 Gene3D G3DSA:1.20.120.530 136 266 5.0E-17 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS09550 afba4a1af2ac680caedf3ce0464911f7 142 SUPERFAMILY SSF54593 1 139 2.89E-35 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS09550 afba4a1af2ac680caedf3ce0464911f7 142 Gene3D G3DSA:3.10.180.10 1 136 6.9E-38 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS09550 afba4a1af2ac680caedf3ce0464911f7 142 Pfam PF13669 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 6 122 3.9E-21 T 09-03-2017 TK78_RS09550 afba4a1af2ac680caedf3ce0464911f7 142 TIGRFAM TIGR03081 metmalonyl_epim: methylmalonyl-CoA epimerase 4 136 1.2E-44 T 09-03-2017 IPR017515 Methylmalonyl-CoA epimerase KEGG: 00280+5.1.99.1|KEGG: 00630+5.1.99.1|KEGG: 00640+5.1.99.1|KEGG: 00720+5.1.99.1|MetaCyc: PWY-5741|MetaCyc: PWY-5743|MetaCyc: PWY-5789|MetaCyc: PWY-6728|MetaCyc: PWY-7384|Reactome: R-HSA-71032 TK78_RS27145 f61b24944763b15376eb13199699bdf1 1047 SUPERFAMILY SSF50677 205 394 6.59E-45 T 09-03-2017 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 TK78_RS27145 f61b24944763b15376eb13199699bdf1 1047 Gene3D G3DSA:1.10.730.10 646 823 9.7E-47 T 09-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS27145 f61b24944763b15376eb13199699bdf1 1047 SUPERFAMILY SSF47323 655 892 3.92E-47 T 09-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS27145 f61b24944763b15376eb13199699bdf1 1047 SUPERFAMILY SSF52374 394 648 8.45E-123 T 09-03-2017 TK78_RS27145 f61b24944763b15376eb13199699bdf1 1047 SUPERFAMILY SSF52374 9 202 8.45E-123 T 09-03-2017 TK78_RS27145 f61b24944763b15376eb13199699bdf1 1047 Gene3D G3DSA:3.90.740.10 207 380 5.9E-50 T 09-03-2017 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 TK78_RS27145 f61b24944763b15376eb13199699bdf1 1047 Hamap MF_02003 Isoleucine--tRNA ligase [ileS]. 7 1045 13.757 T 09-03-2017 IPR023586 Isoleucine-tRNA ligase, type 2 GO:0004822 KEGG: 00970+6.1.1.5|Reactome: R-HSA-2408517|Reactome: R-HSA-379716 TK78_RS27145 f61b24944763b15376eb13199699bdf1 1047 Gene3D G3DSA:3.40.50.620 397 635 1.1E-135 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS27145 f61b24944763b15376eb13199699bdf1 1047 Gene3D G3DSA:3.40.50.620 9 198 1.1E-135 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS27145 f61b24944763b15376eb13199699bdf1 1047 TIGRFAM TIGR00392 ileS: isoleucine--tRNA ligase 9 839 6.8E-269 T 09-03-2017 IPR002301 Isoleucine-tRNA ligase GO:0000166|GO:0004822|GO:0005524|GO:0005737|GO:0006428 KEGG: 00970+6.1.1.5 TK78_RS27145 f61b24944763b15376eb13199699bdf1 1047 Pfam PF08264 Anticodon-binding domain of tRNA 687 832 5.2E-31 T 09-03-2017 IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding GO:0000166|GO:0006418 TK78_RS27145 f61b24944763b15376eb13199699bdf1 1047 PRINTS PR00984 Isoleucyl-tRNA synthetase signature 519 532 3.3E-26 T 09-03-2017 IPR002301 Isoleucine-tRNA ligase GO:0000166|GO:0004822|GO:0005524|GO:0005737|GO:0006428 KEGG: 00970+6.1.1.5 TK78_RS27145 f61b24944763b15376eb13199699bdf1 1047 PRINTS PR00984 Isoleucyl-tRNA synthetase signature 392 407 3.3E-26 T 09-03-2017 IPR002301 Isoleucine-tRNA ligase GO:0000166|GO:0004822|GO:0005524|GO:0005737|GO:0006428 KEGG: 00970+6.1.1.5 TK78_RS27145 f61b24944763b15376eb13199699bdf1 1047 PRINTS PR00984 Isoleucyl-tRNA synthetase signature 45 56 3.3E-26 T 09-03-2017 IPR002301 Isoleucine-tRNA ligase GO:0000166|GO:0004822|GO:0005524|GO:0005737|GO:0006428 KEGG: 00970+6.1.1.5 TK78_RS27145 f61b24944763b15376eb13199699bdf1 1047 PRINTS PR00984 Isoleucyl-tRNA synthetase signature 228 251 3.3E-26 T 09-03-2017 IPR002301 Isoleucine-tRNA ligase GO:0000166|GO:0004822|GO:0005524|GO:0005737|GO:0006428 KEGG: 00970+6.1.1.5 TK78_RS27145 f61b24944763b15376eb13199699bdf1 1047 PRINTS PR00984 Isoleucyl-tRNA synthetase signature 559 568 3.3E-26 T 09-03-2017 IPR002301 Isoleucine-tRNA ligase GO:0000166|GO:0004822|GO:0005524|GO:0005737|GO:0006428 KEGG: 00970+6.1.1.5 TK78_RS27145 f61b24944763b15376eb13199699bdf1 1047 Pfam PF00133 tRNA synthetases class I (I, L, M and V) 22 628 8.2E-167 T 09-03-2017 IPR002300 Aminoacyl-tRNA synthetase, class Ia GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Gene3D G3DSA:3.30.70.250 679 740 4.3E-6 T 09-03-2017 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1688 1703 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SUPERFAMILY SSF51735 1207 1367 1.71E-25 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SUPERFAMILY SSF51735 2947 3133 1.79E-31 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 33 269 4.5E-82 T 09-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1756 2002 9.9E-78 T 09-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SUPERFAMILY SSF51735 1378 1631 1.65E-45 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Gene3D G3DSA:3.40.47.10 1758 2014 3.2E-80 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Gene3D G3DSA:3.40.47.10 35 281 2.9E-84 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SUPERFAMILY SSF53901 31 384 1.97E-102 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1917 1933 - T 09-03-2017 IPR018201 Beta-ketoacyl synthase, active site TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Gene3D G3DSA:3.40.50.1820 3533 3820 1.5E-67 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SMART SM00823 Phosphopantetheine attachment site 3426 3498 6.1E-27 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SMART SM00823 Phosphopantetheine attachment site 1661 1733 4.3E-29 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SUPERFAMILY SSF53474 3564 3820 1.52E-33 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SUPERFAMILY SSF53474 3456 3494 1.52E-33 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 2972 2994 9.3E-5 T 09-03-2017 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 3174 3199 9.3E-5 T 09-03-2017 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3453 3468 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SMART SM00825 Beta-ketoacyl synthase 1758 2180 3.9E-191 T 09-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SMART SM00825 Beta-ketoacyl synthase 35 447 2.4E-203 T 09-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SUPERFAMILY SSF55048 680 741 5.75E-11 T 09-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Gene3D G3DSA:3.40.50.720 3147 3346 8.8E-32 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SUPERFAMILY SSF52151 2486 2580 1.12E-54 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SUPERFAMILY SSF52151 2294 2426 1.12E-54 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SMART SM00826 919 1082 3.8E-76 T 09-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SMART SM00826 2665 2831 1.5E-78 T 09-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 2130 2261 1.5E-13 T 09-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 397 519 3.8E-17 T 09-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SUPERFAMILY SSF51735 3146 3358 1.01E-39 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Gene3D G3DSA:1.10.1200.10 3424 3498 6.2E-19 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Gene3D G3DSA:1.10.1200.10 1659 1733 1.5E-20 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 558 852 1.0E-111 T 09-03-2017 IPR020801 Polyketide synthase, acyl transferase domain TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2298 2595 1.4E-82 T 09-03-2017 IPR020801 Polyketide synthase, acyl transferase domain TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Pfam PF00698 Acyl transferase domain 557 871 5.5E-52 T 09-03-2017 IPR014043 Acyl transferase TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Pfam PF00698 Acyl transferase domain 2297 2613 3.0E-35 T 09-03-2017 IPR014043 Acyl transferase TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 277 393 8.9E-41 T 09-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 2010 2123 1.0E-38 T 09-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Gene3D G3DSA:3.40.50.720 1382 1568 7.8E-33 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SMART SM01294 1662 1729 2.6E-5 T 09-03-2017 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 182 198 - T 09-03-2017 IPR018201 Beta-ketoacyl synthase, active site TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Gene3D G3DSA:3.40.366.10 550 675 5.2E-73 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Gene3D G3DSA:3.40.366.10 2286 2420 2.0E-61 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Gene3D G3DSA:3.40.366.10 741 853 5.2E-73 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Gene3D G3DSA:3.40.366.10 2484 2598 2.0E-61 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Pfam PF08659 KR domain 3147 3321 6.9E-56 T 09-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Pfam PF08659 KR domain 1384 1556 2.0E-57 T 09-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 3147 3323 5.6E-49 T 09-03-2017 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1382 1558 3.1E-53 T 09-03-2017 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SMART SM00824 Thioesterase 3589 3819 5.4E-76 T 09-03-2017 IPR020802 Polyketide synthase, thioesterase domain GO:0009058|GO:0016788 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SUPERFAMILY SSF53901 1753 2117 1.77E-93 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SUPERFAMILY SSF55048 2424 2484 1.96E-8 T 09-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SUPERFAMILY SSF47336 1654 1771 2.75E-22 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Gene3D G3DSA:3.40.47.10 282 447 5.0E-61 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Gene3D G3DSA:3.40.47.10 2015 2179 8.6E-60 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Pfam PF00550 Phosphopantetheine attachment site 3429 3493 9.2E-11 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Pfam PF00550 Phosphopantetheine attachment site 1664 1729 2.3E-11 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SUPERFAMILY SSF52151 742 838 8.11E-69 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 SUPERFAMILY SSF52151 555 681 8.11E-69 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Pfam PF00975 Thioesterase domain 3591 3812 2.5E-21 T 09-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Pfam PF14765 Polyketide synthase dehydratase 919 1196 1.4E-58 T 09-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07135 5bb2d874aa938336195a185d0e333f8f 3823 Pfam PF14765 Polyketide synthase dehydratase 2665 2937 2.3E-52 T 09-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS03110 e82084bc1a356473a0fe6933c6a92924 319 Gene3D G3DSA:3.10.350.10 75 124 3.8E-7 T 09-03-2017 IPR018392 LysM domain TK78_RS03110 e82084bc1a356473a0fe6933c6a92924 319 Pfam PF01476 LysM domain 77 124 2.8E-5 T 09-03-2017 IPR018392 LysM domain TK78_RS03110 e82084bc1a356473a0fe6933c6a92924 319 SUPERFAMILY SSF51261 173 312 4.39E-44 T 09-03-2017 IPR011055 Duplicated hybrid motif TK78_RS03110 e82084bc1a356473a0fe6933c6a92924 319 Pfam PF01551 Peptidase family M23 211 308 1.7E-31 T 09-03-2017 IPR016047 Peptidase M23 TK78_RS03110 e82084bc1a356473a0fe6933c6a92924 319 Gene3D G3DSA:2.70.70.10 173 314 4.1E-43 T 09-03-2017 TK78_RS18600 3b4537b9dbe703b36baff958cc6a112a 331 Pfam PF00877 NlpC/P60 family 207 306 8.8E-24 T 09-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain TK78_RS18600 3b4537b9dbe703b36baff958cc6a112a 331 Gene3D G3DSA:3.90.1720.10 190 317 3.9E-37 T 09-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain TK78_RS18600 3b4537b9dbe703b36baff958cc6a112a 331 Pfam PF01464 Transglycosylase SLT domain 60 170 6.2E-15 T 09-03-2017 IPR008258 Transglycosylase SLT domain 1 TK78_RS18600 3b4537b9dbe703b36baff958cc6a112a 331 SUPERFAMILY SSF53955 43 173 2.35E-32 T 09-03-2017 IPR023346 Lysozyme-like domain TK78_RS18600 3b4537b9dbe703b36baff958cc6a112a 331 Gene3D G3DSA:1.10.530.10 44 187 2.7E-32 T 09-03-2017 TK78_RS18600 3b4537b9dbe703b36baff958cc6a112a 331 SUPERFAMILY SSF54001 190 316 3.43E-35 T 09-03-2017 TK78_RS16910 19c52af4360660c34c4c2e350ad1744a 411 SUPERFAMILY SSF53335 27 98 1.61E-15 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS16910 19c52af4360660c34c4c2e350ad1744a 411 Gene3D G3DSA:3.40.50.150 37 94 1.8E-9 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS16910 19c52af4360660c34c4c2e350ad1744a 411 SUPERFAMILY SSF53335 32 293 4.85E-12 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS16910 19c52af4360660c34c4c2e350ad1744a 411 Gene3D G3DSA:3.40.50.150 253 365 1.2E-8 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS16910 19c52af4360660c34c4c2e350ad1744a 411 SUPERFAMILY SSF53335 253 361 9.12E-11 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS16910 19c52af4360660c34c4c2e350ad1744a 411 Pfam PF01555 DNA methylase 36 89 5.0E-8 T 09-03-2017 IPR002941 DNA methylase N-4/N-6 GO:0003677|GO:0006306|GO:0008170 TK78_RS28720 e2f738b13caace2ca4d48c51fa7f7b90 120 PIRSF PIRSF005965 1 120 8.2E-40 T 09-03-2017 IPR008243 Chorismate mutase, AroH class KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 TK78_RS28720 e2f738b13caace2ca4d48c51fa7f7b90 120 Gene3D G3DSA:3.30.1330.40 3 119 2.8E-42 T 09-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like TK78_RS28720 e2f738b13caace2ca4d48c51fa7f7b90 120 TIGRFAM TIGR01796 CM_mono_aroH: chorismate mutase 3 118 1.4E-45 T 09-03-2017 IPR008243 Chorismate mutase, AroH class KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 TK78_RS28720 e2f738b13caace2ca4d48c51fa7f7b90 120 ProDom PD031888 MUTASE CHORISMATE AROH THE CLASS ISOMERASE TRANSCRIPTION BIOSYNTHESIS CM 3D-STRUCTURE 9 118 8.0E-47 T 09-03-2017 IPR008243 Chorismate mutase, AroH class KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 TK78_RS28720 e2f738b13caace2ca4d48c51fa7f7b90 120 SUPERFAMILY SSF55298 2 118 4.0E-38 T 09-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like TK78_RS28720 e2f738b13caace2ca4d48c51fa7f7b90 120 Pfam PF07736 Chorismate mutase type I 3 118 2.0E-39 T 09-03-2017 IPR008243 Chorismate mutase, AroH class KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 TK78_RS33210 4487dd68f2b5bb4d2ce6d0e8e1b9b14c 260 Gene3D G3DSA:1.10.10.60 212 255 1.2E-9 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS33210 4487dd68f2b5bb4d2ce6d0e8e1b9b14c 260 Pfam PF02311 AraC-like ligand binding domain 36 87 1.5E-4 T 09-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 TK78_RS33210 4487dd68f2b5bb4d2ce6d0e8e1b9b14c 260 SUPERFAMILY SSF51215 30 119 8.76E-9 T 09-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 TK78_RS33210 4487dd68f2b5bb4d2ce6d0e8e1b9b14c 260 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 210 251 - T 09-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 TK78_RS33210 4487dd68f2b5bb4d2ce6d0e8e1b9b14c 260 Pfam PF12833 Helix-turn-helix domain 179 255 4.9E-21 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS33210 4487dd68f2b5bb4d2ce6d0e8e1b9b14c 260 SUPERFAMILY SSF46689 159 206 4.66E-5 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS33210 4487dd68f2b5bb4d2ce6d0e8e1b9b14c 260 Gene3D G3DSA:1.10.10.60 158 211 5.7E-9 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS33210 4487dd68f2b5bb4d2ce6d0e8e1b9b14c 260 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 224 239 3.4E-5 T 09-03-2017 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 TK78_RS33210 4487dd68f2b5bb4d2ce6d0e8e1b9b14c 260 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 239 255 3.4E-5 T 09-03-2017 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 TK78_RS33210 4487dd68f2b5bb4d2ce6d0e8e1b9b14c 260 SUPERFAMILY SSF46689 209 258 5.02E-9 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS33210 4487dd68f2b5bb4d2ce6d0e8e1b9b14c 260 Gene3D G3DSA:2.60.120.280 19 111 5.3E-6 T 09-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 TK78_RS33210 4487dd68f2b5bb4d2ce6d0e8e1b9b14c 260 SMART SM00342 173 255 2.1E-25 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS03205 32d3a5653b8259e7a42cc69eb0305539 313 SUPERFAMILY SSF161111 25 220 4.18E-54 T 09-03-2017 TK78_RS03205 32d3a5653b8259e7a42cc69eb0305539 313 SUPERFAMILY SSF160240 222 301 9.16E-13 T 09-03-2017 TK78_RS03205 32d3a5653b8259e7a42cc69eb0305539 313 Gene3D G3DSA:1.20.1510.10 26 219 9.5E-59 T 09-03-2017 IPR027469 Cation efflux protein transmembrane domain TK78_RS03205 32d3a5653b8259e7a42cc69eb0305539 313 Pfam PF01545 Cation efflux family 28 219 6.0E-46 T 09-03-2017 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 TK78_RS03205 32d3a5653b8259e7a42cc69eb0305539 313 Gene3D G3DSA:3.30.70.1350 227 302 5.7E-5 T 09-03-2017 IPR027470 Cation efflux protein, cytoplasmic domain TK78_RS03205 32d3a5653b8259e7a42cc69eb0305539 313 TIGRFAM TIGR01297 CDF: cation diffusion facilitator family transporter 27 303 4.6E-94 T 09-03-2017 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 TK78_RS30775 307e10331fc9fa0957032a10e0c636ee 259 Gene3D G3DSA:2.60.200.20 158 254 1.2E-28 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS30775 307e10331fc9fa0957032a10e0c636ee 259 Pfam PF13240 zinc-ribbon domain 88 109 4.3E-7 T 09-03-2017 IPR026870 Zinc-ribbon domain TK78_RS30775 307e10331fc9fa0957032a10e0c636ee 259 SMART SM00240 181 232 2.7E-11 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS30775 307e10331fc9fa0957032a10e0c636ee 259 SUPERFAMILY SSF49879 134 253 2.1E-31 T 09-03-2017 IPR008984 SMAD/FHA domain GO:0005515 TK78_RS30775 307e10331fc9fa0957032a10e0c636ee 259 Pfam PF00498 FHA domain 183 246 9.2E-19 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS03395 d7ea64710a8013ef7b072f752b404791 264 SUPERFAMILY SSF54593 137 261 1.02E-16 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS03395 d7ea64710a8013ef7b072f752b404791 264 SUPERFAMILY SSF54593 11 167 8.86E-19 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS03395 d7ea64710a8013ef7b072f752b404791 264 Gene3D G3DSA:3.10.180.10 138 262 2.3E-29 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS03395 d7ea64710a8013ef7b072f752b404791 264 Gene3D G3DSA:3.10.180.10 11 126 1.1E-30 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS13290 af7882a921909542749a317067fc0988 211 SUPERFAMILY SSF51735 1 207 4.05E-34 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS13290 af7882a921909542749a317067fc0988 211 Pfam PF13460 NAD(P)H-binding 7 200 1.0E-44 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS13290 af7882a921909542749a317067fc0988 211 Gene3D G3DSA:3.40.50.720 1 210 3.0E-42 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS15685 ee87cfe9c0ed72bd9ff5505bf2465e70 688 SUPERFAMILY SSF49899 273 453 5.73E-19 T 09-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain TK78_RS15685 ee87cfe9c0ed72bd9ff5505bf2465e70 688 Pfam PF13385 Concanavalin A-like lectin/glucanases superfamily 302 448 3.1E-19 T 09-03-2017 TK78_RS15685 ee87cfe9c0ed72bd9ff5505bf2465e70 688 Pfam PF13385 Concanavalin A-like lectin/glucanases superfamily 519 685 4.5E-14 T 09-03-2017 TK78_RS15685 ee87cfe9c0ed72bd9ff5505bf2465e70 688 SMART SM00560 314 446 1.2E-4 T 09-03-2017 IPR006558 LamG-like jellyroll fold TK78_RS15685 ee87cfe9c0ed72bd9ff5505bf2465e70 688 SMART SM00560 536 682 6.1E-5 T 09-03-2017 IPR006558 LamG-like jellyroll fold TK78_RS15685 ee87cfe9c0ed72bd9ff5505bf2465e70 688 Gene3D G3DSA:2.60.120.200 293 453 1.2E-19 T 09-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain TK78_RS15685 ee87cfe9c0ed72bd9ff5505bf2465e70 688 Gene3D G3DSA:2.60.120.200 512 687 5.3E-19 T 09-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain TK78_RS15685 ee87cfe9c0ed72bd9ff5505bf2465e70 688 SUPERFAMILY SSF49899 502 687 4.85E-18 T 09-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain TK78_RS00405 d5ab6ff2ca014da7e179115fdd75054b 258 SMART SM00420 9 61 9.8E-8 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS00405 d5ab6ff2ca014da7e179115fdd75054b 258 SMART SM01134 76 236 5.5E-47 T 09-03-2017 TK78_RS00405 d5ab6ff2ca014da7e179115fdd75054b 258 Pfam PF00455 DeoR C terminal sensor domain 78 234 2.7E-39 T 09-03-2017 IPR014036 DeoR C-terminal sensor domain TK78_RS00405 d5ab6ff2ca014da7e179115fdd75054b 258 Gene3D G3DSA:3.40.50.1360 79 220 2.1E-9 T 09-03-2017 TK78_RS00405 d5ab6ff2ca014da7e179115fdd75054b 258 ProSitePatterns PS00894 DeoR-type HTH domain signature. 9 43 - T 09-03-2017 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 TK78_RS00405 d5ab6ff2ca014da7e179115fdd75054b 258 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 27 41 7.8E-6 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS00405 d5ab6ff2ca014da7e179115fdd75054b 258 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 41 59 7.8E-6 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS00405 d5ab6ff2ca014da7e179115fdd75054b 258 SUPERFAMILY SSF100950 78 235 8.58E-21 T 09-03-2017 TK78_RS00405 d5ab6ff2ca014da7e179115fdd75054b 258 Gene3D G3DSA:1.10.10.10 7 58 2.7E-7 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS00405 d5ab6ff2ca014da7e179115fdd75054b 258 Pfam PF08220 DeoR-like helix-turn-helix domain 9 63 3.0E-10 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS00405 d5ab6ff2ca014da7e179115fdd75054b 258 SUPERFAMILY SSF46785 7 67 1.33E-10 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS33950 b39678af5852ee3580a8d7cfef982d2d 305 Gene3D G3DSA:3.30.70.1350 218 293 3.7E-5 T 09-03-2017 IPR027470 Cation efflux protein, cytoplasmic domain TK78_RS33950 b39678af5852ee3580a8d7cfef982d2d 305 SUPERFAMILY SSF160240 219 292 3.27E-5 T 09-03-2017 TK78_RS33950 b39678af5852ee3580a8d7cfef982d2d 305 Pfam PF01545 Cation efflux family 15 215 1.6E-34 T 09-03-2017 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 TK78_RS33950 b39678af5852ee3580a8d7cfef982d2d 305 TIGRFAM TIGR01297 CDF: cation diffusion facilitator family transporter 13 298 8.4E-59 T 09-03-2017 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 TK78_RS33950 b39678af5852ee3580a8d7cfef982d2d 305 SUPERFAMILY SSF161111 8 217 8.24E-38 T 09-03-2017 TK78_RS33950 b39678af5852ee3580a8d7cfef982d2d 305 Gene3D G3DSA:1.20.1510.10 12 215 7.4E-33 T 09-03-2017 IPR027469 Cation efflux protein transmembrane domain TK78_RS11990 82118b114933182e09fef04b50aa5685 200 PIRSF PIRSF006305 1 197 1.3E-43 T 09-03-2017 IPR003697 Maf-like protein GO:0005737 TK78_RS11990 82118b114933182e09fef04b50aa5685 200 Pfam PF02545 Maf-like protein 6 190 1.2E-45 T 09-03-2017 IPR003697 Maf-like protein GO:0005737 TK78_RS11990 82118b114933182e09fef04b50aa5685 200 Hamap MF_00528 Septum formation protein Maf [maf]. 6 195 28.57 T 09-03-2017 IPR003697 Maf-like protein GO:0005737 TK78_RS11990 82118b114933182e09fef04b50aa5685 200 SUPERFAMILY SSF52972 5 190 1.44E-53 T 09-03-2017 IPR029001 Inosine triphosphate pyrophosphatase-like TK78_RS11990 82118b114933182e09fef04b50aa5685 200 Gene3D G3DSA:3.90.950.10 5 194 5.9E-60 T 09-03-2017 IPR029001 Inosine triphosphate pyrophosphatase-like TK78_RS11990 82118b114933182e09fef04b50aa5685 200 TIGRFAM TIGR00172 maf: septum formation protein Maf 6 188 6.6E-48 T 09-03-2017 IPR003697 Maf-like protein GO:0005737 TK78_RS16835 7e550e2bfb234526ae250cf0e0628ae3 236 SUPERFAMILY SSF53335 27 219 1.66E-21 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS16835 7e550e2bfb234526ae250cf0e0628ae3 236 Gene3D G3DSA:3.40.50.150 26 216 3.4E-24 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS16835 7e550e2bfb234526ae250cf0e0628ae3 236 Pfam PF13649 Methyltransferase domain 42 129 1.4E-11 T 09-03-2017 TK78_RS34370 3f2d49566c851526b282cbd9a189b52c 356 SUPERFAMILY SSF53335 108 351 9.1E-49 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS34370 3f2d49566c851526b282cbd9a189b52c 356 PIRSF PIRSF005739 5 353 2.0E-50 T 09-03-2017 IPR016461 O-methyltransferase COMT-type GO:0008168 TK78_RS34370 3f2d49566c851526b282cbd9a189b52c 356 Pfam PF00891 O-methyltransferase 115 335 9.6E-51 T 09-03-2017 IPR001077 O-methyltransferase, family 2 GO:0008171 TK78_RS34370 3f2d49566c851526b282cbd9a189b52c 356 Gene3D G3DSA:1.10.10.10 22 111 1.8E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS34370 3f2d49566c851526b282cbd9a189b52c 356 SUPERFAMILY SSF46785 26 103 1.73E-14 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS34370 3f2d49566c851526b282cbd9a189b52c 356 Gene3D G3DSA:3.40.50.150 112 353 4.7E-65 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS34370 3f2d49566c851526b282cbd9a189b52c 356 Pfam PF16864 Dimerisation domain 26 103 2.8E-11 T 09-03-2017 IPR031725 Acetylserotonin O-methyltransferase, dimerisation domain TK78_RS02525 72fd1de440e0d345d803efd6acc20718 480 PIRSF PIRSF000109 1 479 5.1E-199 T 09-03-2017 IPR006113 6-phosphogluconate dehydrogenase, decarboxylating GO:0004616|GO:0006098|GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 TK78_RS02525 72fd1de440e0d345d803efd6acc20718 480 SMART SM01350 181 471 4.5E-200 T 09-03-2017 IPR006114 6-phosphogluconate dehydrogenase, C-terminal GO:0004616|GO:0006098|GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 TK78_RS02525 72fd1de440e0d345d803efd6acc20718 480 Gene3D G3DSA:1.10.1040.10 183 437 9.0E-104 T 09-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 TK78_RS02525 72fd1de440e0d345d803efd6acc20718 480 TIGRFAM TIGR00873 gnd: 6-phosphogluconate dehydrogenase (decarboxylating) 6 470 5.6E-202 T 09-03-2017 IPR006113 6-phosphogluconate dehydrogenase, decarboxylating GO:0004616|GO:0006098|GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 TK78_RS02525 72fd1de440e0d345d803efd6acc20718 480 SUPERFAMILY SSF51735 5 174 2.39E-50 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS02525 72fd1de440e0d345d803efd6acc20718 480 Pfam PF00393 6-phosphogluconate dehydrogenase, C-terminal domain 181 470 6.0E-120 T 09-03-2017 IPR006114 6-phosphogluconate dehydrogenase, C-terminal GO:0004616|GO:0006098|GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 TK78_RS02525 72fd1de440e0d345d803efd6acc20718 480 Gene3D G3DSA:3.40.50.720 4 182 4.4E-57 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS02525 72fd1de440e0d345d803efd6acc20718 480 SUPERFAMILY SSF48179 179 473 1.83E-116 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS02525 72fd1de440e0d345d803efd6acc20718 480 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 252 279 4.5E-80 T 09-03-2017 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 TK78_RS02525 72fd1de440e0d345d803efd6acc20718 480 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 5 28 4.5E-80 T 09-03-2017 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 TK78_RS02525 72fd1de440e0d345d803efd6acc20718 480 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 121 146 4.5E-80 T 09-03-2017 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 TK78_RS02525 72fd1de440e0d345d803efd6acc20718 480 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 170 198 4.5E-80 T 09-03-2017 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 TK78_RS02525 72fd1de440e0d345d803efd6acc20718 480 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 68 97 4.5E-80 T 09-03-2017 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 TK78_RS02525 72fd1de440e0d345d803efd6acc20718 480 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 360 382 4.5E-80 T 09-03-2017 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 TK78_RS02525 72fd1de440e0d345d803efd6acc20718 480 ProSitePatterns PS00461 6-phosphogluconate dehydrogenase signature. 256 268 - T 09-03-2017 IPR006184 6-phosphogluconate-binding site GO:0004616|GO:0006098|GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 TK78_RS02525 72fd1de440e0d345d803efd6acc20718 480 Gene3D G3DSA:1.20.5.320 439 479 1.2E-19 T 09-03-2017 IPR012284 6-phosphogluconate dehydrogenase, domain 3 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 TK78_RS02525 72fd1de440e0d345d803efd6acc20718 480 Pfam PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase 6 171 1.2E-49 T 09-03-2017 IPR006115 6-phosphogluconate dehydrogenase, NADP-binding GO:0004616|GO:0055114 TK78_RS15355 4c68aa1ea605b71906fad1e7e877f3c9 382 TIGRFAM TIGR03819 heli_sec_ATPase: helicase/secretion neighborhood ATPase 6 343 3.0E-154 T 09-03-2017 IPR022399 Helicase/secretion neighbourhood ATPase TK78_RS15355 4c68aa1ea605b71906fad1e7e877f3c9 382 Pfam PF00437 Type II/IV secretion system protein 57 331 2.6E-79 T 09-03-2017 IPR001482 Type II secretion system protein E GO:0005524|GO:0006810 TK78_RS15355 4c68aa1ea605b71906fad1e7e877f3c9 382 Gene3D G3DSA:3.40.50.300 155 351 2.8E-49 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15355 4c68aa1ea605b71906fad1e7e877f3c9 382 SUPERFAMILY SSF52540 44 352 3.52E-48 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15355 4c68aa1ea605b71906fad1e7e877f3c9 382 Gene3D G3DSA:3.30.450.90 53 148 1.9E-26 T 09-03-2017 TK78_RS28035 d640f42a0637af34dcd39fc9851d315d 292 SUPERFAMILY SSF52833 129 288 3.3E-21 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS28035 d640f42a0637af34dcd39fc9851d315d 292 Pfam PF01638 HxlR-like helix-turn-helix 20 105 1.4E-24 T 09-03-2017 IPR002577 Helix-turn-helix, HxlR type TK78_RS28035 d640f42a0637af34dcd39fc9851d315d 292 Gene3D G3DSA:3.40.30.10 133 288 1.1E-22 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS28035 d640f42a0637af34dcd39fc9851d315d 292 Gene3D G3DSA:1.10.10.10 2 106 1.1E-35 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS28035 d640f42a0637af34dcd39fc9851d315d 292 SUPERFAMILY SSF46785 7 110 2.12E-35 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS28035 d640f42a0637af34dcd39fc9851d315d 292 Pfam PF00578 AhpC/TSA family 181 267 1.0E-12 T 09-03-2017 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15|Reactome: R-HSA-3299685 TK78_RS32195 9846a532efb0f0c68541ef0b2f1c0280 310 SUPERFAMILY SSF53850 45 308 7.06E-53 T 09-03-2017 TK78_RS32195 9846a532efb0f0c68541ef0b2f1c0280 310 Gene3D G3DSA:3.40.190.10 41 149 1.7E-42 T 09-03-2017 TK78_RS32195 9846a532efb0f0c68541ef0b2f1c0280 310 Gene3D G3DSA:3.40.190.10 259 308 1.7E-42 T 09-03-2017 TK78_RS32195 9846a532efb0f0c68541ef0b2f1c0280 310 Gene3D G3DSA:3.40.190.120 150 248 2.7E-30 T 09-03-2017 TK78_RS32195 9846a532efb0f0c68541ef0b2f1c0280 310 Pfam PF04069 Substrate binding domain of ABC-type glycine betaine transport system 46 305 2.9E-53 T 09-03-2017 IPR007210 ABC-type glycine betaine transport system, substrate-binding domain GO:0005215|GO:0006810 TK78_RS32535 11a0c65a2f584c34aa7f24b20b04dc23 340 Gene3D G3DSA:3.10.580.10 221 333 2.4E-13 T 09-03-2017 TK78_RS32535 11a0c65a2f584c34aa7f24b20b04dc23 340 Pfam PF00571 CBS domain 283 334 2.9E-7 T 09-03-2017 IPR000644 CBS domain TK78_RS32535 11a0c65a2f584c34aa7f24b20b04dc23 340 SUPERFAMILY SSF54631 220 334 2.07E-16 T 09-03-2017 TK78_RS32535 11a0c65a2f584c34aa7f24b20b04dc23 340 Pfam PF01595 Domain of unknown function DUF21 9 199 2.0E-40 T 09-03-2017 IPR002550 Domain of unknown function DUF21 TK78_RS18975 b773a6610828cc0ba3a8aabc5d26f3d7 450 Gene3D G3DSA:3.40.50.2000 213 415 3.4E-40 T 09-03-2017 TK78_RS18975 b773a6610828cc0ba3a8aabc5d26f3d7 450 SUPERFAMILY SSF53756 32 437 3.84E-83 T 09-03-2017 TK78_RS18975 b773a6610828cc0ba3a8aabc5d26f3d7 450 Pfam PF00534 Glycosyl transferases group 1 243 415 7.7E-31 T 09-03-2017 IPR001296 Glycosyl transferase, family 1 TK78_RS18975 b773a6610828cc0ba3a8aabc5d26f3d7 450 Pfam PF13439 Glycosyltransferase Family 4 51 232 2.1E-31 T 09-03-2017 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 TK78_RS18975 b773a6610828cc0ba3a8aabc5d26f3d7 450 TIGRFAM TIGR03449 mycothiol_MshA: D-inositol-3-phosphate glycosyltransferase 32 438 8.1E-198 T 09-03-2017 IPR017814 Mycothiol biosynthesis protein, MshA GO:0008375|GO:0010125 KEGG: 00500+2.4.1.25|MetaCyc: PWY-5941|MetaCyc: PWY-6724|MetaCyc: PWY-6737|MetaCyc: PWY-7238 TK78_RS18975 b773a6610828cc0ba3a8aabc5d26f3d7 450 Hamap MF_01695 D-inositol-3-phosphate glycosyltransferase [mshA]. 31 442 50.977 T 09-03-2017 IPR017814 Mycothiol biosynthesis protein, MshA GO:0008375|GO:0010125 KEGG: 00500+2.4.1.25|MetaCyc: PWY-5941|MetaCyc: PWY-6724|MetaCyc: PWY-6737|MetaCyc: PWY-7238 TK78_RS10325 2d28b032b512ca82e2ecf76d20fd4d8b 807 Pfam PF00317 Ribonucleotide reductase, all-alpha domain 156 232 2.8E-20 T 09-03-2017 IPR013509 Ribonucleotide reductase large subunit, N-terminal GO:0004748|GO:0005524|GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TK78_RS10325 2d28b032b512ca82e2ecf76d20fd4d8b 807 SUPERFAMILY SSF48168 35 234 5.62E-41 T 09-03-2017 IPR008926 Ribonucleotide reductase R1 subunit, N-terminal KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TK78_RS10325 2d28b032b512ca82e2ecf76d20fd4d8b 807 SUPERFAMILY SSF51998 235 661 6.41E-175 T 09-03-2017 TK78_RS10325 2d28b032b512ca82e2ecf76d20fd4d8b 807 SUPERFAMILY SSF51998 692 762 6.41E-175 T 09-03-2017 TK78_RS10325 2d28b032b512ca82e2ecf76d20fd4d8b 807 TIGRFAM TIGR02506 NrdE_NrdA: ribonucleoside-diphosphate reductase, alpha subunit 159 761 7.4E-226 T 09-03-2017 IPR013346 Ribonucleotide reductase, class I , alpha subunit GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TK78_RS10325 2d28b032b512ca82e2ecf76d20fd4d8b 807 Pfam PF02867 Ribonucleotide reductase, barrel domain 236 757 1.0E-175 T 09-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TK78_RS10325 2d28b032b512ca82e2ecf76d20fd4d8b 807 Gene3D G3DSA:3.20.70.20 408 567 2.8E-77 T 09-03-2017 TK78_RS10325 2d28b032b512ca82e2ecf76d20fd4d8b 807 Gene3D G3DSA:3.20.70.20 612 657 2.8E-77 T 09-03-2017 TK78_RS10325 2d28b032b512ca82e2ecf76d20fd4d8b 807 Gene3D G3DSA:3.20.70.20 154 358 2.8E-77 T 09-03-2017 TK78_RS10325 2d28b032b512ca82e2ecf76d20fd4d8b 807 PRINTS PR01183 Ribonucleotide reductase large chain signature 547 570 5.7E-49 T 09-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TK78_RS10325 2d28b032b512ca82e2ecf76d20fd4d8b 807 PRINTS PR01183 Ribonucleotide reductase large chain signature 444 455 5.7E-49 T 09-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TK78_RS10325 2d28b032b512ca82e2ecf76d20fd4d8b 807 PRINTS PR01183 Ribonucleotide reductase large chain signature 612 639 5.7E-49 T 09-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TK78_RS10325 2d28b032b512ca82e2ecf76d20fd4d8b 807 PRINTS PR01183 Ribonucleotide reductase large chain signature 312 331 5.7E-49 T 09-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TK78_RS10325 2d28b032b512ca82e2ecf76d20fd4d8b 807 PRINTS PR01183 Ribonucleotide reductase large chain signature 481 504 5.7E-49 T 09-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TK78_RS10325 2d28b032b512ca82e2ecf76d20fd4d8b 807 PRINTS PR01183 Ribonucleotide reductase large chain signature 519 541 5.7E-49 T 09-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TK78_RS10325 2d28b032b512ca82e2ecf76d20fd4d8b 807 ProSitePatterns PS00089 Ribonucleotide reductase large subunit signature. 601 623 - T 09-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TK78_RS09980 6c076ec35803c38fb563c7294b5deff5 806 Pfam PF02190 ATP-dependent protease La (LON) substrate-binding domain 13 202 4.3E-16 T 09-03-2017 IPR003111 ATP-dependent protease La (LON), substrate-binding domain GO:0004176|GO:0006508 TK78_RS09980 6c076ec35803c38fb563c7294b5deff5 806 ProSitePatterns PS01046 ATP-dependent serine proteases, lon family, serine active site. 696 704 - T 09-03-2017 IPR008268 Peptidase S16, active site GO:0004176|GO:0004252|GO:0006508 TK78_RS09980 6c076ec35803c38fb563c7294b5deff5 806 SMART SM00464 12 203 5.6E-19 T 09-03-2017 IPR003111 ATP-dependent protease La (LON), substrate-binding domain GO:0004176|GO:0006508 TK78_RS09980 6c076ec35803c38fb563c7294b5deff5 806 Pfam PF05362 Lon protease (S16) C-terminal proteolytic domain 582 792 7.3E-76 T 09-03-2017 IPR008269 Peptidase S16, Lon C-terminal GO:0004176|GO:0004252|GO:0006508 TK78_RS09980 6c076ec35803c38fb563c7294b5deff5 806 Gene3D G3DSA:1.10.8.60 512 595 2.7E-27 T 09-03-2017 TK78_RS09980 6c076ec35803c38fb563c7294b5deff5 806 PIRSF PIRSF001174 1 794 6.6E-243 T 09-03-2017 IPR004815 Lon protease, bacterial/eukaryotic-type GO:0004176|GO:0005524|GO:0006508 TK78_RS09980 6c076ec35803c38fb563c7294b5deff5 806 SUPERFAMILY SSF88697 12 201 3.23E-21 T 09-03-2017 IPR015947 PUA-like domain TK78_RS09980 6c076ec35803c38fb563c7294b5deff5 806 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 693 712 6.6E-50 T 09-03-2017 TK78_RS09980 6c076ec35803c38fb563c7294b5deff5 806 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 612 628 6.6E-50 T 09-03-2017 TK78_RS09980 6c076ec35803c38fb563c7294b5deff5 806 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 723 742 6.6E-50 T 09-03-2017 TK78_RS09980 6c076ec35803c38fb563c7294b5deff5 806 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 367 386 6.6E-50 T 09-03-2017 TK78_RS09980 6c076ec35803c38fb563c7294b5deff5 806 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 746 764 6.6E-50 T 09-03-2017 TK78_RS09980 6c076ec35803c38fb563c7294b5deff5 806 SMART SM00382 359 504 5.4E-10 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS09980 6c076ec35803c38fb563c7294b5deff5 806 Gene3D G3DSA:3.30.230.10 607 791 3.1E-69 T 09-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TK78_RS09980 6c076ec35803c38fb563c7294b5deff5 806 Hamap MF_01973 Lon protease [lon]. 13 792 57.984 T 09-03-2017 IPR027543 Lon protease, bacterial GO:0004176|GO:0004252|GO:0005524|GO:0006508|GO:0043565 TK78_RS09980 6c076ec35803c38fb563c7294b5deff5 806 TIGRFAM TIGR00763 lon: endopeptidase La 14 791 4.8E-238 T 09-03-2017 IPR004815 Lon protease, bacterial/eukaryotic-type GO:0004176|GO:0005524|GO:0006508 TK78_RS09980 6c076ec35803c38fb563c7294b5deff5 806 SUPERFAMILY SSF52540 310 573 4.33E-48 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09980 6c076ec35803c38fb563c7294b5deff5 806 Gene3D G3DSA:3.40.50.300 310 511 3.2E-32 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09980 6c076ec35803c38fb563c7294b5deff5 806 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 364 499 3.1E-20 T 09-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 TK78_RS09980 6c076ec35803c38fb563c7294b5deff5 806 SUPERFAMILY SSF54211 612 790 2.05E-51 T 09-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold TK78_RS14535 c7b14ce9fd27092501638e2c5ba8a9e1 162 SUPERFAMILY SSF51182 21 109 1.25E-13 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS14535 c7b14ce9fd27092501638e2c5ba8a9e1 162 Pfam PF02311 AraC-like ligand binding domain 49 109 8.2E-5 T 09-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 TK78_RS14535 c7b14ce9fd27092501638e2c5ba8a9e1 162 Gene3D G3DSA:2.60.120.10 28 109 1.1E-10 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS06635 465d5663c92b3de85223faa3c17d10d7 525 Gene3D G3DSA:3.40.309.10 282 468 2.5E-49 T 09-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 TK78_RS06635 465d5663c92b3de85223faa3c17d10d7 525 SUPERFAMILY SSF53720 38 517 9.29E-93 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS06635 465d5663c92b3de85223faa3c17d10d7 525 Gene3D G3DSA:3.40.605.10 26 279 4.3E-43 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS06635 465d5663c92b3de85223faa3c17d10d7 525 Pfam PF00171 Aldehyde dehydrogenase family 47 445 3.4E-46 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS15055 2e6853dd8f33c4ff39fb1cf28742ca0d 141 Pfam PF00392 Bacterial regulatory proteins, gntR family 24 87 3.8E-13 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS15055 2e6853dd8f33c4ff39fb1cf28742ca0d 141 SMART SM00345 28 87 7.1E-13 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS15055 2e6853dd8f33c4ff39fb1cf28742ca0d 141 SUPERFAMILY SSF46785 17 89 5.91E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS15055 2e6853dd8f33c4ff39fb1cf28742ca0d 141 Gene3D G3DSA:1.10.10.10 15 88 1.1E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS13675 13e10721051c481c5ce17d66706bce5b 414 SUPERFAMILY SSF103473 3 386 1.96E-53 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS13675 13e10721051c481c5ce17d66706bce5b 414 Gene3D G3DSA:1.20.1250.20 204 389 1.4E-12 T 09-03-2017 TK78_RS13675 13e10721051c481c5ce17d66706bce5b 414 Gene3D G3DSA:1.20.1250.20 5 180 3.8E-25 T 09-03-2017 TK78_RS13675 13e10721051c481c5ce17d66706bce5b 414 Pfam PF07690 Major Facilitator Superfamily 9 332 1.6E-30 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS03340 002b0204d19ee8414d46b559a5611d94 145 SUPERFAMILY SSF52833 70 141 2.24E-9 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS03340 002b0204d19ee8414d46b559a5611d94 145 Gene3D G3DSA:3.40.30.10 70 135 1.4E-7 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS03340 002b0204d19ee8414d46b559a5611d94 145 Pfam PF00462 Glutaredoxin 70 127 2.1E-6 T 09-03-2017 IPR002109 Glutaredoxin GO:0009055|GO:0015035|GO:0045454 TK78_RS13855 d4ed5df3aad3e3e034636ce49a37ebde 302 Hamap MF_00188 Protease HtpX [htpX]. 10 296 25.132 T 09-03-2017 IPR022919 Peptidase M48, protease HtpX, putative GO:0004222 TK78_RS13855 d4ed5df3aad3e3e034636ce49a37ebde 302 Pfam PF01435 Peptidase family M48 78 296 1.7E-35 T 09-03-2017 IPR001915 Peptidase M48 GO:0004222|GO:0006508 TK78_RS13855 d4ed5df3aad3e3e034636ce49a37ebde 302 Gene3D G3DSA:3.30.2010.10 71 161 8.9E-32 T 09-03-2017 TK78_RS05685 b1c99dff7406ebe408b7f9b247e4fcb4 382 Gene3D G3DSA:3.40.350.10 12 150 1.4E-15 T 09-03-2017 IPR029149 Creatinase/Aminopeptidase P/Spt16, N-terminal TK78_RS05685 b1c99dff7406ebe408b7f9b247e4fcb4 382 Pfam PF00557 Metallopeptidase family M24 165 365 9.6E-55 T 09-03-2017 IPR000994 Peptidase M24, structural domain TK78_RS05685 b1c99dff7406ebe408b7f9b247e4fcb4 382 Pfam PF01321 Creatinase/Prolidase N-terminal domain 25 156 7.6E-14 T 09-03-2017 IPR000587 Creatinase, N-terminal GO:0016787 TK78_RS05685 b1c99dff7406ebe408b7f9b247e4fcb4 382 SUPERFAMILY SSF53092 13 154 1.18E-17 T 09-03-2017 IPR028980 Creatinase/Aminopeptidase P, N-terminal TK78_RS05685 b1c99dff7406ebe408b7f9b247e4fcb4 382 Gene3D G3DSA:3.90.230.10 156 381 9.6E-68 T 09-03-2017 IPR000994 Peptidase M24, structural domain TK78_RS05685 b1c99dff7406ebe408b7f9b247e4fcb4 382 SUPERFAMILY SSF55920 155 381 2.75E-71 T 09-03-2017 IPR000994 Peptidase M24, structural domain TK78_RS03590 bc5652ef6a4ab1ea3637e0b61f93ad4b 158 Pfam PF13581 Histidine kinase-like ATPase domain 27 126 4.2E-12 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS03590 bc5652ef6a4ab1ea3637e0b61f93ad4b 158 SUPERFAMILY SSF55874 54 145 1.19E-9 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS03590 bc5652ef6a4ab1ea3637e0b61f93ad4b 158 Gene3D G3DSA:3.30.565.10 34 98 4.3E-5 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS02170 5c1a664f1e65d1908e7058bf52cb2ca5 71 SUPERFAMILY SSF89807 3 68 1.22E-25 T 09-03-2017 IPR009923 Dodecin TK78_RS02170 5c1a664f1e65d1908e7058bf52cb2ca5 71 Pfam PF07311 Dodecin 5 68 9.4E-30 T 09-03-2017 IPR009923 Dodecin TK78_RS02170 5c1a664f1e65d1908e7058bf52cb2ca5 71 Gene3D G3DSA:3.30.1660.10 3 69 1.2E-35 T 09-03-2017 IPR025543 Dodecin-like TK78_RS12710 df9fbcc50865024ef0a26940b995c635 500 SMART SM01240 15 486 0.0 T 09-03-2017 TK78_RS12710 df9fbcc50865024ef0a26940b995c635 500 Pfam PF00478 IMP dehydrogenase / GMP reductase domain 16 486 2.4E-155 T 09-03-2017 IPR001093 IMP dehydrogenase/GMP reductase GO:0003824|GO:0055114 TK78_RS12710 df9fbcc50865024ef0a26940b995c635 500 SUPERFAMILY SSF54631 92 211 2.65E-29 T 09-03-2017 TK78_RS12710 df9fbcc50865024ef0a26940b995c635 500 SUPERFAMILY SSF51412 11 98 2.59E-117 T 09-03-2017 TK78_RS12710 df9fbcc50865024ef0a26940b995c635 500 SUPERFAMILY SSF51412 224 490 2.59E-117 T 09-03-2017 TK78_RS12710 df9fbcc50865024ef0a26940b995c635 500 PIRSF PIRSF000130 7 500 3.4E-199 T 09-03-2017 IPR005990 Inosine-5'-monophosphate dehydrogenase GO:0003938|GO:0006164|GO:0055114 KEGG: 00053+1.1.1.20|KEGG: 00230+1.1.1.205|KEGG: 00983+1.1.1.205|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-7221|Reactome: R-HSA-73817 TK78_RS12710 df9fbcc50865024ef0a26940b995c635 500 TIGRFAM TIGR01302 IMP_dehydrog: inosine-5'-monophosphate dehydrogenase 16 467 5.4E-179 T 09-03-2017 IPR005990 Inosine-5'-monophosphate dehydrogenase GO:0003938|GO:0006164|GO:0055114 KEGG: 00053+1.1.1.20|KEGG: 00230+1.1.1.205|KEGG: 00983+1.1.1.205|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-7221|Reactome: R-HSA-73817 TK78_RS12710 df9fbcc50865024ef0a26940b995c635 500 ProSitePatterns PS00487 IMP dehydrogenase / GMP reductase signature. 301 313 - T 09-03-2017 IPR015875 IMP dehydrogenase / GMP reductase, conserved site GO:0016491|GO:0055114 TK78_RS12710 df9fbcc50865024ef0a26940b995c635 500 SMART SM00116 165 213 4.6E-7 T 09-03-2017 IPR000644 CBS domain TK78_RS12710 df9fbcc50865024ef0a26940b995c635 500 SMART SM00116 104 152 8.1E-10 T 09-03-2017 IPR000644 CBS domain TK78_RS12710 df9fbcc50865024ef0a26940b995c635 500 Gene3D G3DSA:3.20.20.70 11 498 2.3E-191 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS12710 df9fbcc50865024ef0a26940b995c635 500 Pfam PF00571 CBS domain 157 212 1.3E-5 T 09-03-2017 IPR000644 CBS domain TK78_RS12710 df9fbcc50865024ef0a26940b995c635 500 Pfam PF00571 CBS domain 101 148 1.2E-9 T 09-03-2017 IPR000644 CBS domain TK78_RS12710 df9fbcc50865024ef0a26940b995c635 500 Hamap MF_01964 Inosine-5'-monophosphate dehydrogenase [guaB]. 16 499 82.29 T 09-03-2017 IPR005990 Inosine-5'-monophosphate dehydrogenase GO:0003938|GO:0006164|GO:0055114 KEGG: 00053+1.1.1.20|KEGG: 00230+1.1.1.205|KEGG: 00983+1.1.1.205|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-7221|Reactome: R-HSA-73817 TK78_RS01625 1d09d0222c989694ee1328cce9f9bcfe 572 PRINTS PR01806 Virulence factor MviN signature 320 346 6.2E-16 T 09-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ TK78_RS01625 1d09d0222c989694ee1328cce9f9bcfe 572 PRINTS PR01806 Virulence factor MviN signature 212 233 6.2E-16 T 09-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ TK78_RS01625 1d09d0222c989694ee1328cce9f9bcfe 572 PRINTS PR01806 Virulence factor MviN signature 417 436 6.2E-16 T 09-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ TK78_RS01625 1d09d0222c989694ee1328cce9f9bcfe 572 PRINTS PR01806 Virulence factor MviN signature 104 120 6.2E-16 T 09-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ TK78_RS01625 1d09d0222c989694ee1328cce9f9bcfe 572 PRINTS PR01806 Virulence factor MviN signature 85 104 6.2E-16 T 09-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ TK78_RS01625 1d09d0222c989694ee1328cce9f9bcfe 572 PRINTS PR01806 Virulence factor MviN signature 470 487 6.2E-16 T 09-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ TK78_RS01625 1d09d0222c989694ee1328cce9f9bcfe 572 Pfam PF03023 MviN-like protein 80 520 2.0E-60 T 09-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ TK78_RS03695 be46e71aac4e98682382d220829c1e1b 455 PRINTS PR00463 E-class P450 group I signature 257 274 2.2E-25 T 09-03-2017 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS03695 be46e71aac4e98682382d220829c1e1b 455 PRINTS PR00463 E-class P450 group I signature 277 303 2.2E-25 T 09-03-2017 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS03695 be46e71aac4e98682382d220829c1e1b 455 PRINTS PR00463 E-class P450 group I signature 319 337 2.2E-25 T 09-03-2017 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS03695 be46e71aac4e98682382d220829c1e1b 455 PRINTS PR00463 E-class P450 group I signature 359 383 2.2E-25 T 09-03-2017 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS03695 be46e71aac4e98682382d220829c1e1b 455 PRINTS PR00463 E-class P450 group I signature 45 64 2.2E-25 T 09-03-2017 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS03695 be46e71aac4e98682382d220829c1e1b 455 PRINTS PR00463 E-class P450 group I signature 404 427 2.2E-25 T 09-03-2017 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS03695 be46e71aac4e98682382d220829c1e1b 455 PRINTS PR00463 E-class P450 group I signature 394 404 2.2E-25 T 09-03-2017 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS03695 be46e71aac4e98682382d220829c1e1b 455 SUPERFAMILY SSF48264 17 455 5.89E-114 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS03695 be46e71aac4e98682382d220829c1e1b 455 Pfam PF00067 Cytochrome P450 20 433 4.7E-89 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS03695 be46e71aac4e98682382d220829c1e1b 455 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 397 406 - T 09-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 TK78_RS03695 be46e71aac4e98682382d220829c1e1b 455 PRINTS PR00385 P450 superfamily signature 395 404 1.0E-15 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS03695 be46e71aac4e98682382d220829c1e1b 455 PRINTS PR00385 P450 superfamily signature 404 415 1.0E-15 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS03695 be46e71aac4e98682382d220829c1e1b 455 PRINTS PR00385 P450 superfamily signature 320 331 1.0E-15 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS03695 be46e71aac4e98682382d220829c1e1b 455 PRINTS PR00385 P450 superfamily signature 268 285 1.0E-15 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS03695 be46e71aac4e98682382d220829c1e1b 455 Gene3D G3DSA:1.10.630.10 19 455 2.6E-122 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS15680 68e5cafbf74975fae279b51547fdd605 423 TIGRFAM TIGR00656 asp_kin_monofn: aspartate kinase, monofunctional class 2 407 6.8E-126 T 09-03-2017 IPR005260 Aspartate kinase, monofunctional class GO:0004072|GO:0009089 KEGG: 00260+2.7.2.4|KEGG: 00261+2.7.2.4|KEGG: 00270+2.7.2.4|KEGG: 00300+2.7.2.4|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153 TK78_RS15680 68e5cafbf74975fae279b51547fdd605 423 SUPERFAMILY SSF53633 4 244 1.7E-71 T 09-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase TK78_RS15680 68e5cafbf74975fae279b51547fdd605 423 PIRSF PIRSF000726 59 415 3.2E-126 T 09-03-2017 IPR005260 Aspartate kinase, monofunctional class GO:0004072|GO:0009089 KEGG: 00260+2.7.2.4|KEGG: 00261+2.7.2.4|KEGG: 00270+2.7.2.4|KEGG: 00300+2.7.2.4|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153 TK78_RS15680 68e5cafbf74975fae279b51547fdd605 423 Pfam PF13840 ACT domain 342 403 1.1E-13 T 09-03-2017 IPR027795 GATS-like ACT domain TK78_RS15680 68e5cafbf74975fae279b51547fdd605 423 SUPERFAMILY SSF55021 334 409 3.09E-22 T 09-03-2017 TK78_RS15680 68e5cafbf74975fae279b51547fdd605 423 Gene3D G3DSA:3.40.1160.10 3 245 2.2E-70 T 09-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase TK78_RS15680 68e5cafbf74975fae279b51547fdd605 423 Pfam PF00696 Amino acid kinase family 3 231 1.8E-54 T 09-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase TK78_RS15680 68e5cafbf74975fae279b51547fdd605 423 SUPERFAMILY SSF55021 252 331 3.31E-17 T 09-03-2017 TK78_RS15680 68e5cafbf74975fae279b51547fdd605 423 Pfam PF01842 ACT domain 269 318 1.5E-8 T 09-03-2017 IPR002912 ACT domain GO:0008152|GO:0016597 TK78_RS15680 68e5cafbf74975fae279b51547fdd605 423 Gene3D G3DSA:3.30.70.260 268 336 9.5E-4 T 09-03-2017 TK78_RS15680 68e5cafbf74975fae279b51547fdd605 423 ProSitePatterns PS00324 Aspartokinase signature. 5 13 - T 09-03-2017 IPR018042 Aspartate kinase, conserved site GO:0004072|GO:0008652 KEGG: 00260+2.7.2.4|KEGG: 00261+2.7.2.4|KEGG: 00270+2.7.2.4|KEGG: 00300+2.7.2.4|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153 TK78_RS15680 68e5cafbf74975fae279b51547fdd605 423 TIGRFAM TIGR00657 asp_kinases: aspartate kinase 64 407 9.6E-114 T 09-03-2017 IPR001341 Aspartate kinase domain GO:0004072|GO:0008652 KEGG: 00260+2.7.2.4|KEGG: 00261+2.7.2.4|KEGG: 00270+2.7.2.4|KEGG: 00300+2.7.2.4|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153 TK78_RS23760 19f3d54b2df6eed82f650ae30a348584 870 SMART SM01260 524 849 3.6E-4 T 09-03-2017 IPR007822 Lanthionine synthetase C-like TK78_RS23760 19f3d54b2df6eed82f650ae30a348584 870 PRINTS PR01955 Frankia sp. LanC-like protein signature 767 787 7.8E-7 T 09-03-2017 IPR020434 LanC-like protein TK78_RS23760 19f3d54b2df6eed82f650ae30a348584 870 PRINTS PR01955 Frankia sp. LanC-like protein signature 824 841 7.8E-7 T 09-03-2017 IPR020434 LanC-like protein TK78_RS23760 19f3d54b2df6eed82f650ae30a348584 870 PRINTS PR01955 Frankia sp. LanC-like protein signature 528 544 7.8E-7 T 09-03-2017 IPR020434 LanC-like protein TK78_RS23760 19f3d54b2df6eed82f650ae30a348584 870 Gene3D G3DSA:3.90.1200.10 371 390 4.8E-4 T 09-03-2017 TK78_RS23760 19f3d54b2df6eed82f650ae30a348584 870 Pfam PF00069 Protein kinase domain 239 397 2.1E-8 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS23760 19f3d54b2df6eed82f650ae30a348584 870 Gene3D G3DSA:3.30.200.20 228 370 1.1E-10 T 09-03-2017 TK78_RS23760 19f3d54b2df6eed82f650ae30a348584 870 SUPERFAMILY SSF56112 228 430 8.77E-24 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS23760 19f3d54b2df6eed82f650ae30a348584 870 SMART SM00220 228 516 2.6E-4 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS27780 90b7b2bc92d5ce678d326826a1d01bef 185 Hamap MF_00772 Methylated-DNA--protein-cysteine methyltransferase [ogt]. 12 180 35.355 T 09-03-2017 IPR023546 Methylated-DNA--protein-cysteine methyltransferase GO:0003824|GO:0006281 TK78_RS27780 90b7b2bc92d5ce678d326826a1d01bef 185 Gene3D G3DSA:3.30.160.70 11 92 4.1E-8 T 09-03-2017 TK78_RS27780 90b7b2bc92d5ce678d326826a1d01bef 185 SUPERFAMILY SSF46767 98 179 1.57E-24 T 09-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 TK78_RS27780 90b7b2bc92d5ce678d326826a1d01bef 185 TIGRFAM TIGR00589 ogt: methylated-DNA--[protein]-cysteine S-methyltransferase 99 177 5.6E-27 T 09-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 TK78_RS27780 90b7b2bc92d5ce678d326826a1d01bef 185 Pfam PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 99 179 6.1E-28 T 09-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 TK78_RS27780 90b7b2bc92d5ce678d326826a1d01bef 185 ProSitePatterns PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 148 154 - T 09-03-2017 IPR001497 Methylated-DNA-[protein]-cysteine S-methyltransferase, active site GO:0003908|GO:0006281 Reactome: R-HSA-5657655 TK78_RS27780 90b7b2bc92d5ce678d326826a1d01bef 185 Gene3D G3DSA:1.10.10.10 98 179 2.2E-29 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS27780 90b7b2bc92d5ce678d326826a1d01bef 185 SUPERFAMILY SSF53155 12 93 5.49E-10 T 09-03-2017 IPR008332 Methylguanine DNA methyltransferase, ribonuclease-like domain GO:0003908|GO:0006281 Reactome: R-HSA-5657655 TK78_RS24475 13763988985e38432721719da9328a11 642 SMART SM00729 264 487 3.6E-28 T 09-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 TK78_RS24475 13763988985e38432721719da9328a11 642 Pfam PF04055 Radical SAM superfamily 268 429 2.0E-14 T 09-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 TK78_RS24475 13763988985e38432721719da9328a11 642 TIGRFAM TIGR03960 rSAM_fuse_unch: radical SAM family uncharacterized protein 12 617 3.0E-212 T 09-03-2017 IPR023862 Conserved hypothetical protein CHP03960, radical SAM TK78_RS24475 13763988985e38432721719da9328a11 642 SUPERFAMILY SSF102114 232 632 2.75E-50 T 09-03-2017 TK78_RS24475 13763988985e38432721719da9328a11 642 Gene3D G3DSA:3.80.30.20 263 492 3.8E-44 T 09-03-2017 IPR023404 Radical SAM, alpha/beta horseshoe TK78_RS11100 63c61152613f69105851367a4fb8b1d8 279 Gene3D G3DSA:1.10.260.40 17 59 2.9E-6 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS11100 63c61152613f69105851367a4fb8b1d8 279 SUPERFAMILY SSF47413 17 64 1.99E-6 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS28475 1a3b9b9090130ca0ccb00a89e8b543e5 241 Gene3D G3DSA:3.40.50.720 3 219 5.9E-54 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS28475 1a3b9b9090130ca0ccb00a89e8b543e5 241 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 140 168 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS28475 1a3b9b9090130ca0ccb00a89e8b543e5 241 SUPERFAMILY SSF51735 2 219 1.62E-49 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS28475 1a3b9b9090130ca0ccb00a89e8b543e5 241 Pfam PF00106 short chain dehydrogenase 3 192 2.3E-37 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS28475 1a3b9b9090130ca0ccb00a89e8b543e5 241 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 77 88 4.6E-22 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS28475 1a3b9b9090130ca0ccb00a89e8b543e5 241 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 3 20 4.6E-22 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS28475 1a3b9b9090130ca0ccb00a89e8b543e5 241 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 172 189 4.6E-22 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS28475 1a3b9b9090130ca0ccb00a89e8b543e5 241 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 153 172 4.6E-22 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS28475 1a3b9b9090130ca0ccb00a89e8b543e5 241 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 127 143 4.6E-22 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS28475 1a3b9b9090130ca0ccb00a89e8b543e5 241 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 77 88 3.5E-5 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS28475 1a3b9b9090130ca0ccb00a89e8b543e5 241 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 133 141 3.5E-5 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS28475 1a3b9b9090130ca0ccb00a89e8b543e5 241 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 153 172 3.5E-5 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS07405 b68cd646becc0f04c712fe939a1e473a 288 Gene3D G3DSA:3.10.310.10 132 270 3.1E-40 T 09-03-2017 TK78_RS07405 b68cd646becc0f04c712fe939a1e473a 288 SUPERFAMILY SSF54506 6 136 6.59E-35 T 09-03-2017 TK78_RS07405 b68cd646becc0f04c712fe939a1e473a 288 Pfam PF01678 Diaminopimelate epimerase 8 134 2.8E-36 T 09-03-2017 IPR001653 Diaminopimelate epimerase, DapF GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097 TK78_RS07405 b68cd646becc0f04c712fe939a1e473a 288 Pfam PF01678 Diaminopimelate epimerase 154 275 1.1E-28 T 09-03-2017 IPR001653 Diaminopimelate epimerase, DapF GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097 TK78_RS07405 b68cd646becc0f04c712fe939a1e473a 288 SUPERFAMILY SSF54506 142 281 5.16E-36 T 09-03-2017 TK78_RS07405 b68cd646becc0f04c712fe939a1e473a 288 Hamap MF_00197 Diaminopimelate epimerase [dapF]. 6 282 31.467 T 09-03-2017 IPR001653 Diaminopimelate epimerase, DapF GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097 TK78_RS07405 b68cd646becc0f04c712fe939a1e473a 288 Gene3D G3DSA:3.10.310.10 7 131 2.0E-41 T 09-03-2017 TK78_RS07405 b68cd646becc0f04c712fe939a1e473a 288 TIGRFAM TIGR00652 DapF: diaminopimelate epimerase 6 280 4.2E-68 T 09-03-2017 IPR001653 Diaminopimelate epimerase, DapF GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097 TK78_RS07405 b68cd646becc0f04c712fe939a1e473a 288 ProSitePatterns PS01326 Diaminopimelate epimerase signature. 77 91 - T 09-03-2017 IPR018510 Diaminopimelate epimerase, active site GO:0005737|GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097 TK78_RS19325 b1cdc96f44a446f8498013f2866d7856 557 Pfam PF00037 4Fe-4S binding domain 40 61 4.3E-8 T 09-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TK78_RS19325 b1cdc96f44a446f8498013f2866d7856 557 PRINTS PR00419 Adrenodoxin reductase family signature 143 156 5.2E-20 T 09-03-2017 TK78_RS19325 b1cdc96f44a446f8498013f2866d7856 557 PRINTS PR00419 Adrenodoxin reductase family signature 258 272 5.2E-20 T 09-03-2017 TK78_RS19325 b1cdc96f44a446f8498013f2866d7856 557 PRINTS PR00419 Adrenodoxin reductase family signature 186 196 5.2E-20 T 09-03-2017 TK78_RS19325 b1cdc96f44a446f8498013f2866d7856 557 PRINTS PR00419 Adrenodoxin reductase family signature 119 141 5.2E-20 T 09-03-2017 TK78_RS19325 b1cdc96f44a446f8498013f2866d7856 557 SUPERFAMILY SSF51971 374 422 9.42E-51 T 09-03-2017 TK78_RS19325 b1cdc96f44a446f8498013f2866d7856 557 SUPERFAMILY SSF51971 117 324 9.42E-51 T 09-03-2017 TK78_RS19325 b1cdc96f44a446f8498013f2866d7856 557 SUPERFAMILY SSF51971 412 544 1.41E-5 T 09-03-2017 TK78_RS19325 b1cdc96f44a446f8498013f2866d7856 557 Gene3D G3DSA:3.50.50.60 209 421 4.1E-56 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS19325 b1cdc96f44a446f8498013f2866d7856 557 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 119 274 2.6E-13 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS19325 b1cdc96f44a446f8498013f2866d7856 557 Gene3D G3DSA:3.40.50.720 422 546 8.5E-68 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS19325 b1cdc96f44a446f8498013f2866d7856 557 Gene3D G3DSA:3.40.50.720 117 208 8.5E-68 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS19325 b1cdc96f44a446f8498013f2866d7856 557 SUPERFAMILY SSF54862 3 76 4.6E-15 T 09-03-2017 TK78_RS19325 b1cdc96f44a446f8498013f2866d7856 557 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 46 57 - T 09-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TK78_RS19325 b1cdc96f44a446f8498013f2866d7856 557 Gene3D G3DSA:3.30.70.20 6 69 9.3E-15 T 09-03-2017 TK78_RS20625 b51b081dd05605eb761b6fa8d6a222c9 527 Pfam PF00474 Sodium:solute symporter family 33 417 4.9E-30 T 09-03-2017 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 TK78_RS33840 772fee57d721c7b530ddbab2ab2d994c 401 Pfam PF00425 chorismate binding enzyme 135 389 3.0E-77 T 09-03-2017 IPR015890 Chorismate-utilising enzyme, C-terminal TK78_RS33840 772fee57d721c7b530ddbab2ab2d994c 401 SUPERFAMILY SSF56322 44 398 9.29E-95 T 09-03-2017 IPR005801 ADC synthase GO:0009058 TK78_RS33840 772fee57d721c7b530ddbab2ab2d994c 401 TIGRFAM TIGR00543 isochor_syn: isochorismate synthase 130 396 1.3E-86 T 09-03-2017 IPR004561 Isochorismate synthase GO:0008909|GO:0009058 KEGG: 00130+5.4.4.2|MetaCyc: PWY-5837|MetaCyc: PWY-5901|MetaCyc: PWY-6406 TK78_RS33840 772fee57d721c7b530ddbab2ab2d994c 401 Gene3D G3DSA:3.60.120.10 118 398 1.7E-93 T 09-03-2017 IPR005801 ADC synthase GO:0009058 TK78_RS27200 863f8744a88412f894682fbfc541a782 1178 SUPERFAMILY SSF89550 7 92 9.68E-31 T 09-03-2017 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 TK78_RS27200 863f8744a88412f894682fbfc541a782 1178 SUPERFAMILY SSF89550 120 268 9.68E-31 T 09-03-2017 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 TK78_RS27200 863f8744a88412f894682fbfc541a782 1178 Gene3D G3DSA:3.20.20.140 7 268 1.0E-40 T 09-03-2017 TK78_RS27200 863f8744a88412f894682fbfc541a782 1178 Pfam PF02811 PHP domain 8 194 2.0E-45 T 09-03-2017 IPR004013 PHP domain GO:0003824 TK78_RS27200 863f8744a88412f894682fbfc541a782 1178 Pfam PF14579 Helix-hairpin-helix motif 830 917 1.1E-23 T 09-03-2017 IPR029460 DNA polymerase, helix-hairpin-helix motif KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS27200 863f8744a88412f894682fbfc541a782 1178 Pfam PF01336 OB-fold nucleic acid binding domain 1019 1098 3.2E-7 T 09-03-2017 IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type GO:0003676 TK78_RS27200 863f8744a88412f894682fbfc541a782 1178 Gene3D G3DSA:2.40.50.140 1014 1096 7.9E-5 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS27200 863f8744a88412f894682fbfc541a782 1178 TIGRFAM TIGR00594 polc: DNA polymerase III, alpha subunit 6 1056 0.0 T 09-03-2017 IPR004805 DNA polymerase III, alpha subunit GO:0006260|GO:0008408 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS27200 863f8744a88412f894682fbfc541a782 1178 SMART SM00481 7 74 3.1E-30 T 09-03-2017 IPR003141 Polymerase/histidinol phosphatase, N-terminal GO:0003677|GO:0003887|GO:0006260 TK78_RS27200 863f8744a88412f894682fbfc541a782 1178 Pfam PF07733 Bacterial DNA polymerase III alpha subunit 316 756 5.9E-165 T 09-03-2017 IPR011708 Bacterial DNA polymerase III, alpha subunit GO:0006260|GO:0008408 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS00235 8c144356981f134fb44eb7df27af1f3b 436 SUPERFAMILY SSF52091 332 399 1.28E-6 T 09-03-2017 IPR002645 STAS domain TK78_RS00235 8c144356981f134fb44eb7df27af1f3b 436 Hamap MF_00313 Glutaminase [glsA]. 5 307 40.25 T 09-03-2017 IPR015868 Glutaminase GO:0004359|GO:0006541 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|Reactome: R-HSA-210500|Reactome: R-HSA-5628897|Reactome: R-HSA-70614 TK78_RS00235 8c144356981f134fb44eb7df27af1f3b 436 Gene3D G3DSA:3.30.750.24 333 399 6.3E-6 T 09-03-2017 IPR002645 STAS domain TK78_RS00235 8c144356981f134fb44eb7df27af1f3b 436 SUPERFAMILY SSF56601 5 307 3.05E-108 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS00235 8c144356981f134fb44eb7df27af1f3b 436 TIGRFAM TIGR03814 Gln_ase: glutaminase A 14 306 7.8E-101 T 09-03-2017 IPR015868 Glutaminase GO:0004359|GO:0006541 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|Reactome: R-HSA-210500|Reactome: R-HSA-5628897|Reactome: R-HSA-70614 TK78_RS00235 8c144356981f134fb44eb7df27af1f3b 436 Pfam PF04960 Glutaminase 22 306 2.4E-113 T 09-03-2017 IPR015868 Glutaminase GO:0004359|GO:0006541 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|Reactome: R-HSA-210500|Reactome: R-HSA-5628897|Reactome: R-HSA-70614 TK78_RS00235 8c144356981f134fb44eb7df27af1f3b 436 Gene3D G3DSA:3.40.710.10 5 308 3.8E-123 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS17545 0563189731f3e37888926473a441c2b5 276 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 14 27 2.7E-10 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS17545 0563189731f3e37888926473a441c2b5 276 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 35 58 2.7E-10 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS17545 0563189731f3e37888926473a441c2b5 276 SUPERFAMILY SSF48498 74 200 8.01E-27 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS17545 0563189731f3e37888926473a441c2b5 276 Gene3D G3DSA:1.10.357.10 3 186 7.3E-31 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS17545 0563189731f3e37888926473a441c2b5 276 Pfam PF00440 Bacterial regulatory proteins, tetR family 14 60 2.1E-15 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS17545 0563189731f3e37888926473a441c2b5 276 SUPERFAMILY SSF46689 3 66 9.75E-15 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS24560 644c7df610a1b656b36e9dcc5f4996ff 372 TIGRFAM TIGR01027 proB: glutamate 5-kinase 5 364 6.2E-128 T 09-03-2017 IPR005715 Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase GO:0005737|GO:0006561 KEGG: 00330+2.7.2.11|KEGG: 00332+2.7.2.11|MetaCyc: PWY-3341|MetaCyc: PWY-6922|Reactome: R-HSA-70614 TK78_RS24560 644c7df610a1b656b36e9dcc5f4996ff 372 Hamap MF_00456 Glutamate 5-kinase [proB]. 5 256 35.511 T 09-03-2017 IPR005715 Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase GO:0005737|GO:0006561 KEGG: 00330+2.7.2.11|KEGG: 00332+2.7.2.11|MetaCyc: PWY-3341|MetaCyc: PWY-6922|Reactome: R-HSA-70614 TK78_RS24560 644c7df610a1b656b36e9dcc5f4996ff 372 Pfam PF01472 PUA domain 275 348 2.4E-17 T 09-03-2017 IPR002478 PUA domain GO:0003723 TK78_RS24560 644c7df610a1b656b36e9dcc5f4996ff 372 Pfam PF00696 Amino acid kinase family 6 236 2.1E-40 T 09-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase TK78_RS24560 644c7df610a1b656b36e9dcc5f4996ff 372 SMART SM00359 275 354 6.3E-16 T 09-03-2017 IPR002478 PUA domain GO:0003723 TK78_RS24560 644c7df610a1b656b36e9dcc5f4996ff 372 PIRSF PIRSF000729 1 367 3.8E-122 T 09-03-2017 IPR011529 Glutamate 5-kinase GO:0004349|GO:0005737|GO:0006561 KEGG: 00330+2.7.2.11|KEGG: 00332+2.7.2.11|MetaCyc: PWY-3341|MetaCyc: PWY-6922 TK78_RS24560 644c7df610a1b656b36e9dcc5f4996ff 372 SUPERFAMILY SSF53633 5 254 5.24E-62 T 09-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase TK78_RS24560 644c7df610a1b656b36e9dcc5f4996ff 372 Gene3D G3DSA:2.30.130.10 272 364 4.6E-25 T 09-03-2017 IPR015947 PUA-like domain TK78_RS24560 644c7df610a1b656b36e9dcc5f4996ff 372 SUPERFAMILY SSF88697 275 365 1.93E-21 T 09-03-2017 IPR015947 PUA-like domain TK78_RS24560 644c7df610a1b656b36e9dcc5f4996ff 372 Gene3D G3DSA:3.40.1160.10 5 254 9.0E-55 T 09-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase TK78_RS24560 644c7df610a1b656b36e9dcc5f4996ff 372 ProSitePatterns PS00902 Glutamate 5-kinase signature. 208 225 - T 09-03-2017 IPR019797 Glutamate 5-kinase, conserved site GO:0004349|GO:0006561 KEGG: 00330+2.7.2.11|KEGG: 00332+2.7.2.11|MetaCyc: PWY-3341|MetaCyc: PWY-6922|Reactome: R-HSA-70614 TK78_RS24560 644c7df610a1b656b36e9dcc5f4996ff 372 PRINTS PR00474 Glutamate 5-kinase family signature 43 57 1.3E-53 T 09-03-2017 IPR001057 Glutamate/acetylglutamate kinase GO:0006561 Reactome: R-HSA-70614 TK78_RS24560 644c7df610a1b656b36e9dcc5f4996ff 372 PRINTS PR00474 Glutamate 5-kinase family signature 77 105 1.3E-53 T 09-03-2017 IPR001057 Glutamate/acetylglutamate kinase GO:0006561 Reactome: R-HSA-70614 TK78_RS24560 644c7df610a1b656b36e9dcc5f4996ff 372 PRINTS PR00474 Glutamate 5-kinase family signature 117 138 1.3E-53 T 09-03-2017 IPR001057 Glutamate/acetylglutamate kinase GO:0006561 Reactome: R-HSA-70614 TK78_RS24560 644c7df610a1b656b36e9dcc5f4996ff 372 PRINTS PR00474 Glutamate 5-kinase family signature 149 176 1.3E-53 T 09-03-2017 IPR001057 Glutamate/acetylglutamate kinase GO:0006561 Reactome: R-HSA-70614 TK78_RS24560 644c7df610a1b656b36e9dcc5f4996ff 372 PRINTS PR00474 Glutamate 5-kinase family signature 210 230 1.3E-53 T 09-03-2017 IPR001057 Glutamate/acetylglutamate kinase GO:0006561 Reactome: R-HSA-70614 TK78_RS12195 75e3101dc3de69c9d71043eb8b0fd390 412 SUPERFAMILY SSF55031 205 318 6.13E-21 T 09-03-2017 IPR011650 Peptidase M20, dimerisation domain TK78_RS12195 75e3101dc3de69c9d71043eb8b0fd390 412 TIGRFAM TIGR01891 amidohydrolases: amidohydrolase 32 397 1.4E-98 T 09-03-2017 IPR017439 Amidohydrolase GO:0016787 TK78_RS12195 75e3101dc3de69c9d71043eb8b0fd390 412 Gene3D G3DSA:3.30.70.360 204 319 7.4E-28 T 09-03-2017 IPR011650 Peptidase M20, dimerisation domain TK78_RS12195 75e3101dc3de69c9d71043eb8b0fd390 412 SUPERFAMILY SSF53187 26 219 4.32E-64 T 09-03-2017 TK78_RS12195 75e3101dc3de69c9d71043eb8b0fd390 412 SUPERFAMILY SSF53187 320 406 4.32E-64 T 09-03-2017 TK78_RS12195 75e3101dc3de69c9d71043eb8b0fd390 412 Pfam PF07687 Peptidase dimerisation domain 208 302 1.8E-6 T 09-03-2017 IPR011650 Peptidase M20, dimerisation domain TK78_RS12195 75e3101dc3de69c9d71043eb8b0fd390 412 PIRSF PIRSF005962 22 411 1.7E-94 T 09-03-2017 IPR017439 Amidohydrolase GO:0016787 TK78_RS12195 75e3101dc3de69c9d71043eb8b0fd390 412 Pfam PF01546 Peptidase family M20/M25/M40 91 405 2.3E-26 T 09-03-2017 IPR002933 Peptidase M20 GO:0008152|GO:0016787 TK78_RS12195 75e3101dc3de69c9d71043eb8b0fd390 412 Gene3D G3DSA:3.40.630.10 320 406 1.9E-85 T 09-03-2017 TK78_RS12195 75e3101dc3de69c9d71043eb8b0fd390 412 Gene3D G3DSA:3.40.630.10 26 200 1.9E-85 T 09-03-2017 TK78_RS14195 02efb0acc02562a5c85b05145761acaa 202 Pfam PF00440 Bacterial regulatory proteins, tetR family 29 72 2.0E-12 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS14195 02efb0acc02562a5c85b05145761acaa 202 SUPERFAMILY SSF46689 17 91 2.49E-18 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS14195 02efb0acc02562a5c85b05145761acaa 202 Gene3D G3DSA:1.10.357.10 15 201 8.5E-30 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS14195 02efb0acc02562a5c85b05145761acaa 202 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 50 73 3.2E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS14195 02efb0acc02562a5c85b05145761acaa 202 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 29 42 3.2E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS27575 6b1f7db83f7372d463d29265d5f9cd0e 608 PRINTS PR01607 Apyrase family signature 535 554 2.8E-21 T 09-03-2017 IPR006179 5'-Nucleotidase/apyrase GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 TK78_RS27575 6b1f7db83f7372d463d29265d5f9cd0e 608 PRINTS PR01607 Apyrase family signature 51 69 2.8E-21 T 09-03-2017 IPR006179 5'-Nucleotidase/apyrase GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 TK78_RS27575 6b1f7db83f7372d463d29265d5f9cd0e 608 PRINTS PR01607 Apyrase family signature 444 467 2.8E-21 T 09-03-2017 IPR006179 5'-Nucleotidase/apyrase GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 TK78_RS27575 6b1f7db83f7372d463d29265d5f9cd0e 608 PRINTS PR01607 Apyrase family signature 250 267 2.8E-21 T 09-03-2017 IPR006179 5'-Nucleotidase/apyrase GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 TK78_RS27575 6b1f7db83f7372d463d29265d5f9cd0e 608 PRINTS PR01607 Apyrase family signature 283 306 2.8E-21 T 09-03-2017 IPR006179 5'-Nucleotidase/apyrase GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 TK78_RS27575 6b1f7db83f7372d463d29265d5f9cd0e 608 ProSitePatterns PS00786 5'-nucleotidase signature 2. 148 159 - T 09-03-2017 IPR006146 5'-Nucleotidase, conserved site GO:0000166|GO:0016788|GO:0046872 Reactome: R-HSA-73621|Reactome: R-HSA-74259 TK78_RS27575 6b1f7db83f7372d463d29265d5f9cd0e 608 Pfam PF02872 5'-nucleotidase, C-terminal domain 381 560 1.8E-28 T 09-03-2017 IPR008334 5'-Nucleotidase, C-terminal GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 TK78_RS27575 6b1f7db83f7372d463d29265d5f9cd0e 608 Gene3D G3DSA:3.90.780.10 381 590 1.2E-39 T 09-03-2017 IPR008334 5'-Nucleotidase, C-terminal GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 TK78_RS27575 6b1f7db83f7372d463d29265d5f9cd0e 608 Gene3D G3DSA:3.60.21.10 48 380 7.4E-78 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS27575 6b1f7db83f7372d463d29265d5f9cd0e 608 SUPERFAMILY SSF56300 47 380 8.44E-76 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS27575 6b1f7db83f7372d463d29265d5f9cd0e 608 Pfam PF00149 Calcineurin-like phosphoesterase 53 300 1.1E-10 T 09-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 TK78_RS27575 6b1f7db83f7372d463d29265d5f9cd0e 608 SUPERFAMILY SSF55816 378 590 1.96E-40 T 09-03-2017 IPR008334 5'-Nucleotidase, C-terminal GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 TK78_RS24810 c802484adfe4e5a89857d7c23f721bd7 354 Pfam PF02562 PhoH-like protein 124 327 1.0E-94 T 09-03-2017 IPR003714 PhoH-like protein GO:0005524 TK78_RS24810 c802484adfe4e5a89857d7c23f721bd7 354 SUPERFAMILY SSF52540 123 302 1.13E-40 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24810 c802484adfe4e5a89857d7c23f721bd7 354 Gene3D G3DSA:3.40.50.300 123 327 1.2E-102 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09100 895039c45c7eaaf624f7944f50a8ec9f 518 SUPERFAMILY SSF53850 30 502 2.33E-75 T 09-03-2017 TK78_RS09100 895039c45c7eaaf624f7944f50a8ec9f 518 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 76 435 1.7E-49 T 09-03-2017 IPR000914 Solute-binding protein family 5 domain TK78_RS09100 895039c45c7eaaf624f7944f50a8ec9f 518 Gene3D G3DSA:3.10.105.10 289 485 6.0E-34 T 09-03-2017 TK78_RS09100 895039c45c7eaaf624f7944f50a8ec9f 518 Gene3D G3DSA:3.90.76.10 65 159 7.5E-13 T 09-03-2017 TK78_RS09100 895039c45c7eaaf624f7944f50a8ec9f 518 Gene3D G3DSA:3.40.190.10 160 288 2.4E-17 T 09-03-2017 TK78_RS09100 895039c45c7eaaf624f7944f50a8ec9f 518 PIRSF PIRSF002741 1 510 2.5E-41 T 09-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 TK78_RS13410 aec822b20174e8ba4a7e92b42c1198c0 322 Hamap MF_01350 NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic [ndhA]. 3 321 22.527 T 09-03-2017 IPR001694 NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H GO:0016020|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13410 aec822b20174e8ba4a7e92b42c1198c0 322 Pfam PF00146 NADH dehydrogenase 11 314 1.8E-101 T 09-03-2017 IPR001694 NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H GO:0016020|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS15920 aaee817661c25391a32c30e3234d6c6b 427 ProSitePatterns PS01266 Adenylosuccinate synthetase GTP-binding site. 10 17 - T 09-03-2017 IPR018220 Adenylosuccinate synthase, GTP-binding site GO:0005525 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: R-HSA-73817 TK78_RS15920 aaee817661c25391a32c30e3234d6c6b 427 Gene3D G3DSA:3.90.170.10 266 422 6.0E-68 T 09-03-2017 TK78_RS15920 aaee817661c25391a32c30e3234d6c6b 427 Gene3D G3DSA:1.10.300.10 101 194 2.5E-33 T 09-03-2017 TK78_RS15920 aaee817661c25391a32c30e3234d6c6b 427 Hamap MF_00011 Adenylosuccinate synthetase [purA]. 1 427 200.042 T 09-03-2017 IPR001114 Adenylosuccinate synthetase GO:0004019|GO:0005525|GO:0006164 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: R-HSA-73817 TK78_RS15920 aaee817661c25391a32c30e3234d6c6b 427 Gene3D G3DSA:3.40.440.10 195 264 5.1E-71 T 09-03-2017 TK78_RS15920 aaee817661c25391a32c30e3234d6c6b 427 Gene3D G3DSA:3.40.440.10 4 93 5.1E-71 T 09-03-2017 TK78_RS15920 aaee817661c25391a32c30e3234d6c6b 427 Pfam PF00709 Adenylosuccinate synthetase 5 421 2.6E-177 T 09-03-2017 IPR001114 Adenylosuccinate synthetase GO:0004019|GO:0005525|GO:0006164 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: R-HSA-73817 TK78_RS15920 aaee817661c25391a32c30e3234d6c6b 427 SMART SM00788 3 422 1.4E-285 T 09-03-2017 IPR001114 Adenylosuccinate synthetase GO:0004019|GO:0005525|GO:0006164 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: R-HSA-73817 TK78_RS15920 aaee817661c25391a32c30e3234d6c6b 427 ProSitePatterns PS00513 Adenylosuccinate synthetase active site. 131 142 - T 09-03-2017 IPR033128 Adenylosuccinate synthase, active site KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: R-HSA-73817 TK78_RS15920 aaee817661c25391a32c30e3234d6c6b 427 TIGRFAM TIGR00184 purA: adenylosuccinate synthase 5 423 9.9E-168 T 09-03-2017 IPR001114 Adenylosuccinate synthetase GO:0004019|GO:0005525|GO:0006164 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: R-HSA-73817 TK78_RS15920 aaee817661c25391a32c30e3234d6c6b 427 SUPERFAMILY SSF52540 3 425 2.97E-173 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13920 561353d341879fd77e8df5fedd5dd554 280 SUPERFAMILY SSF51735 4 223 2.63E-43 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS13920 561353d341879fd77e8df5fedd5dd554 280 Pfam PF13460 NAD(P)H-binding 9 176 2.9E-19 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS13920 561353d341879fd77e8df5fedd5dd554 280 Gene3D G3DSA:3.40.50.720 5 208 8.5E-33 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS32330 b3495e57cca69a241ecfe6abc4b8a42c 197 Gene3D G3DSA:1.10.10.10 1 87 1.1E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32330 b3495e57cca69a241ecfe6abc4b8a42c 197 Pfam PF10400 Virulence activator alpha C-term 92 178 5.8E-25 T 09-03-2017 IPR018309 Transcription regulator PadR, C-terminal TK78_RS32330 b3495e57cca69a241ecfe6abc4b8a42c 197 Pfam PF03551 Transcriptional regulator PadR-like family 7 80 7.8E-12 T 09-03-2017 IPR005149 Transcription regulator PadR, N-terminal TK78_RS32330 b3495e57cca69a241ecfe6abc4b8a42c 197 SUPERFAMILY SSF46785 3 180 1.45E-40 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS02940 f7750ed2c88475dda3f543094fb54255 300 Pfam PF02780 Transketolase, C-terminal domain 178 288 8.2E-8 T 09-03-2017 IPR033248 Transketolase, C-terminal domain TK78_RS02940 f7750ed2c88475dda3f543094fb54255 300 SMART SM00861 2 166 1.0E-16 T 09-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain TK78_RS02940 f7750ed2c88475dda3f543094fb54255 300 Gene3D G3DSA:3.40.50.920 177 296 1.4E-9 T 09-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 TK78_RS02940 f7750ed2c88475dda3f543094fb54255 300 Gene3D G3DSA:3.40.50.970 3 163 8.1E-23 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS02940 f7750ed2c88475dda3f543094fb54255 300 SUPERFAMILY SSF52922 177 297 8.51E-13 T 09-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 TK78_RS02940 f7750ed2c88475dda3f543094fb54255 300 SUPERFAMILY SSF52518 3 163 6.42E-32 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS02940 f7750ed2c88475dda3f543094fb54255 300 Pfam PF02779 Transketolase, pyrimidine binding domain 9 163 3.2E-19 T 09-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain TK78_RS11335 f316b9bd71bddcaae992323a908b1625 362 Hamap MF_00944 Ribosome-binding ATPase YchF [ychF]. 2 362 42.278 T 09-03-2017 IPR004396 Ribosome-binding ATPase YchF/Obg-like ATPase 1 GO:0005525 TK78_RS11335 f316b9bd71bddcaae992323a908b1625 362 Pfam PF01926 50S ribosome-binding GTPase 5 123 1.1E-22 T 09-03-2017 IPR006073 GTP binding domain GO:0005525 TK78_RS11335 f316b9bd71bddcaae992323a908b1625 362 SUPERFAMILY SSF52540 3 300 3.74E-73 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS11335 f316b9bd71bddcaae992323a908b1625 362 Gene3D G3DSA:3.10.20.30 262 362 2.2E-45 T 09-03-2017 IPR012675 Beta-grasp domain TK78_RS11335 f316b9bd71bddcaae992323a908b1625 362 Gene3D G3DSA:1.10.150.300 132 201 2.9E-19 T 09-03-2017 IPR023192 TGS-like domain TK78_RS11335 f316b9bd71bddcaae992323a908b1625 362 SUPERFAMILY SSF81271 278 362 2.4E-35 T 09-03-2017 IPR012676 TGS-like KEGG: 00970+6.1.1.3 TK78_RS11335 f316b9bd71bddcaae992323a908b1625 362 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 5 25 3.2E-34 T 09-03-2017 IPR006073 GTP binding domain GO:0005525 TK78_RS11335 f316b9bd71bddcaae992323a908b1625 362 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 87 105 3.2E-34 T 09-03-2017 IPR006073 GTP binding domain GO:0005525 TK78_RS11335 f316b9bd71bddcaae992323a908b1625 362 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 26 44 3.2E-34 T 09-03-2017 IPR006073 GTP binding domain GO:0005525 TK78_RS11335 f316b9bd71bddcaae992323a908b1625 362 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 70 85 3.2E-34 T 09-03-2017 IPR006073 GTP binding domain GO:0005525 TK78_RS11335 f316b9bd71bddcaae992323a908b1625 362 PIRSF PIRSF006641 1 362 3.9E-141 T 09-03-2017 IPR004396 Ribosome-binding ATPase YchF/Obg-like ATPase 1 GO:0005525 TK78_RS11335 f316b9bd71bddcaae992323a908b1625 362 Gene3D G3DSA:3.40.50.300 3 131 5.7E-43 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS11335 f316b9bd71bddcaae992323a908b1625 362 Gene3D G3DSA:3.40.50.300 202 261 5.7E-43 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS11335 f316b9bd71bddcaae992323a908b1625 362 Pfam PF06071 Protein of unknown function (DUF933) 278 361 2.4E-39 T 09-03-2017 IPR013029 Domain of unknown function DUF933 TK78_RS11335 f316b9bd71bddcaae992323a908b1625 362 TIGRFAM TIGR00092 TIGR00092: GTP-binding protein YchF 3 362 1.5E-133 T 09-03-2017 IPR004396 Ribosome-binding ATPase YchF/Obg-like ATPase 1 GO:0005525 TK78_RS03295 64d08db828cc870920d5b648de683736 524 SUPERFAMILY SSF63737 32 224 8.37E-35 T 09-03-2017 TK78_RS03295 64d08db828cc870920d5b648de683736 524 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 314 329 2.1E-10 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS03295 64d08db828cc870920d5b648de683736 524 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 161 176 2.1E-10 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS03295 64d08db828cc870920d5b648de683736 524 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 333 345 2.1E-10 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS03295 64d08db828cc870920d5b648de683736 524 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 208 223 2.1E-10 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS03295 64d08db828cc870920d5b648de683736 524 Gene3D G3DSA:1.10.390.10 328 461 7.6E-21 T 09-03-2017 TK78_RS03295 64d08db828cc870920d5b648de683736 524 Pfam PF01433 Peptidase family M1 48 358 1.7E-40 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS03295 64d08db828cc870920d5b648de683736 524 SUPERFAMILY SSF55486 249 461 9.82E-49 T 09-03-2017 TK78_RS26680 b1f22e09a7c061854fb42501e393f79d 362 SUPERFAMILY SSF50156 290 361 6.7E-18 T 09-03-2017 IPR001478 PDZ domain GO:0005515 TK78_RS26680 b1f22e09a7c061854fb42501e393f79d 362 SUPERFAMILY SSF50494 60 268 8.9E-52 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS26680 b1f22e09a7c061854fb42501e393f79d 362 PRINTS PR00834 HtrA/DegQ protease family signature 199 216 6.4E-34 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS26680 b1f22e09a7c061854fb42501e393f79d 362 PRINTS PR00834 HtrA/DegQ protease family signature 115 135 6.4E-34 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS26680 b1f22e09a7c061854fb42501e393f79d 362 PRINTS PR00834 HtrA/DegQ protease family signature 93 105 6.4E-34 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS26680 b1f22e09a7c061854fb42501e393f79d 362 PRINTS PR00834 HtrA/DegQ protease family signature 308 320 6.4E-34 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS26680 b1f22e09a7c061854fb42501e393f79d 362 PRINTS PR00834 HtrA/DegQ protease family signature 221 238 6.4E-34 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS26680 b1f22e09a7c061854fb42501e393f79d 362 PRINTS PR00834 HtrA/DegQ protease family signature 157 181 6.4E-34 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS26680 b1f22e09a7c061854fb42501e393f79d 362 Gene3D G3DSA:2.40.10.10 77 157 3.1E-23 T 09-03-2017 TK78_RS26680 b1f22e09a7c061854fb42501e393f79d 362 Gene3D G3DSA:2.30.42.10 289 361 2.9E-19 T 09-03-2017 IPR001478 PDZ domain GO:0005515 TK78_RS26680 b1f22e09a7c061854fb42501e393f79d 362 Gene3D G3DSA:2.40.10.10 158 269 6.4E-37 T 09-03-2017 TK78_RS26680 b1f22e09a7c061854fb42501e393f79d 362 Pfam PF13365 Trypsin-like peptidase domain 84 228 2.5E-28 T 09-03-2017 TK78_RS26680 b1f22e09a7c061854fb42501e393f79d 362 SMART SM00228 272 350 9.5E-7 T 09-03-2017 IPR001478 PDZ domain GO:0005515 TK78_RS26680 b1f22e09a7c061854fb42501e393f79d 362 Pfam PF13180 PDZ domain 290 359 2.6E-18 T 09-03-2017 IPR001478 PDZ domain GO:0005515 TK78_RS07275 dfe5eb15186fea8793e8cbbd11c0df08 577 SUPERFAMILY SSF52540 13 216 1.41E-38 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07275 dfe5eb15186fea8793e8cbbd11c0df08 577 SMART SM00382 28 205 3.4E-4 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS07275 dfe5eb15186fea8793e8cbbd11c0df08 577 Gene3D G3DSA:3.40.50.300 14 223 6.6E-40 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07275 dfe5eb15186fea8793e8cbbd11c0df08 577 Pfam PF00005 ABC transporter 20 156 2.9E-16 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS26965 328f48c3a204329f0e5e3e1e8b8ea02a 402 TIGRFAM TIGR02352 thiamin_ThiO: glycine oxidase ThiO 21 376 5.0E-123 T 09-03-2017 IPR012727 Glycine oxidase ThiO GO:0016491|GO:0050660 TK78_RS26965 328f48c3a204329f0e5e3e1e8b8ea02a 402 SUPERFAMILY SSF51905 334 394 8.67E-49 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS26965 328f48c3a204329f0e5e3e1e8b8ea02a 402 SUPERFAMILY SSF51905 20 239 8.67E-49 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS26965 328f48c3a204329f0e5e3e1e8b8ea02a 402 SUPERFAMILY SSF54373 240 332 4.97E-22 T 09-03-2017 TK78_RS26965 328f48c3a204329f0e5e3e1e8b8ea02a 402 Gene3D G3DSA:3.30.9.10 239 331 5.1E-11 T 09-03-2017 TK78_RS26965 328f48c3a204329f0e5e3e1e8b8ea02a 402 Gene3D G3DSA:3.30.9.10 107 159 5.1E-11 T 09-03-2017 TK78_RS26965 328f48c3a204329f0e5e3e1e8b8ea02a 402 Pfam PF01266 FAD dependent oxidoreductase 20 371 3.6E-68 T 09-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 TK78_RS26965 328f48c3a204329f0e5e3e1e8b8ea02a 402 Gene3D G3DSA:3.50.50.60 334 392 6.3E-47 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS26965 328f48c3a204329f0e5e3e1e8b8ea02a 402 Gene3D G3DSA:3.50.50.60 160 238 6.3E-47 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS26965 328f48c3a204329f0e5e3e1e8b8ea02a 402 Gene3D G3DSA:3.50.50.60 19 98 6.3E-47 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS11445 9a4fac1a1a60a65a099202d711c8a781 471 Gene3D G3DSA:1.20.200.10 143 407 3.6E-95 T 09-03-2017 TK78_RS11445 9a4fac1a1a60a65a099202d711c8a781 471 SUPERFAMILY SSF48557 14 469 1.48E-144 T 09-03-2017 IPR008948 L-Aspartase-like GO:0003824 TK78_RS11445 9a4fac1a1a60a65a099202d711c8a781 471 Hamap MF_00743 Fumarate hydratase class II [fumC]. 14 471 81.875 T 09-03-2017 IPR005677 Fumarate hydratase, class II GO:0004333|GO:0006106|GO:0045239 KEGG: 00020+4.2.1.2|KEGG: 00620+4.2.1.2|KEGG: 00720+4.2.1.2|MetaCyc: PWY-5392|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7384|Reactome: R-HSA-71403 TK78_RS11445 9a4fac1a1a60a65a099202d711c8a781 471 Gene3D G3DSA:1.10.40.30 412 471 2.3E-22 T 09-03-2017 TK78_RS11445 9a4fac1a1a60a65a099202d711c8a781 471 Gene3D G3DSA:1.10.275.10 13 142 5.8E-53 T 09-03-2017 IPR024083 Fumarase/histidase, N-terminal TK78_RS11445 9a4fac1a1a60a65a099202d711c8a781 471 PRINTS PR00145 Argininosuccinate lyase family signature 179 199 6.2E-5 T 09-03-2017 TK78_RS11445 9a4fac1a1a60a65a099202d711c8a781 471 PRINTS PR00145 Argininosuccinate lyase family signature 321 337 6.2E-5 T 09-03-2017 TK78_RS11445 9a4fac1a1a60a65a099202d711c8a781 471 PRINTS PR00149 Fumarate lyase superfamily signature 138 156 3.9E-33 T 09-03-2017 IPR000362 Fumarate lyase family TK78_RS11445 9a4fac1a1a60a65a099202d711c8a781 471 PRINTS PR00149 Fumarate lyase superfamily signature 184 202 3.9E-33 T 09-03-2017 IPR000362 Fumarate lyase family TK78_RS11445 9a4fac1a1a60a65a099202d711c8a781 471 PRINTS PR00149 Fumarate lyase superfamily signature 321 337 3.9E-33 T 09-03-2017 IPR000362 Fumarate lyase family TK78_RS11445 9a4fac1a1a60a65a099202d711c8a781 471 PRINTS PR00149 Fumarate lyase superfamily signature 275 302 3.9E-33 T 09-03-2017 IPR000362 Fumarate lyase family TK78_RS11445 9a4fac1a1a60a65a099202d711c8a781 471 Pfam PF00206 Lyase 22 346 6.5E-101 T 09-03-2017 IPR022761 Fumarate lyase, N-terminal TK78_RS11445 9a4fac1a1a60a65a099202d711c8a781 471 Pfam PF10415 Fumarase C C-terminus 412 470 2.2E-20 T 09-03-2017 IPR018951 Fumarase C, C-terminal GO:0006099|GO:0016829 KEGG: 00020+4.2.1.2|KEGG: 00620+4.2.1.2|KEGG: 00720+4.2.1.2|MetaCyc: PWY-5392|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7384|Reactome: R-HSA-71403 TK78_RS11445 9a4fac1a1a60a65a099202d711c8a781 471 ProSitePatterns PS00163 Fumarate lyases signature. 321 330 - T 09-03-2017 IPR020557 Fumarate lyase, conserved site GO:0003824 TK78_RS33345 f1bdd8cb91b204809677122d94d9d343 351 Pfam PF05239 PRC-barrel domain 12 72 1.4E-10 T 09-03-2017 IPR027275 PRC-barrel domain TK78_RS33345 f1bdd8cb91b204809677122d94d9d343 351 SUPERFAMILY SSF50346 2 109 9.89E-23 T 09-03-2017 IPR011033 PRC-barrel-like TK78_RS33345 f1bdd8cb91b204809677122d94d9d343 351 Gene3D G3DSA:3.90.50.10 14 104 9.7E-7 T 09-03-2017 IPR014747 Bacterial photosynthetic reaction centre, H-chain, C-terminal GO:0019684|GO:0030077|GO:0045156 TK78_RS33345 f1bdd8cb91b204809677122d94d9d343 351 Pfam PF09557 Domain of unknown function (DUF2382) 219 328 5.3E-29 T 09-03-2017 IPR019060 Domain of unknown function DUF2382 TK78_RS00815 9e0ef1b2e0f486dc16c2b92686d32695 206 Pfam PF01300 Telomere recombination 24 198 5.5E-44 T 09-03-2017 IPR006070 YrdC-like domain GO:0003725 TK78_RS00815 9e0ef1b2e0f486dc16c2b92686d32695 206 SUPERFAMILY SSF55821 1 204 6.71E-60 T 09-03-2017 IPR017945 DHBP synthase RibB-like alpha/beta domain TK78_RS00815 9e0ef1b2e0f486dc16c2b92686d32695 206 Gene3D G3DSA:3.90.870.10 2 204 3.2E-61 T 09-03-2017 IPR017945 DHBP synthase RibB-like alpha/beta domain TK78_RS00815 9e0ef1b2e0f486dc16c2b92686d32695 206 TIGRFAM TIGR00057 TIGR00057: tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family 7 201 1.9E-56 T 09-03-2017 IPR006070 YrdC-like domain GO:0003725 TK78_RS32720 829936588d15d69913024d0c5b88db5b 320 SUPERFAMILY SSF52402 3 186 4.4E-32 T 09-03-2017 TK78_RS32720 829936588d15d69913024d0c5b88db5b 320 Gene3D G3DSA:3.40.50.1220 190 316 6.8E-58 T 09-03-2017 IPR029035 DHS-like NAD/FAD-binding domain TK78_RS32720 829936588d15d69913024d0c5b88db5b 320 Gene3D G3DSA:3.40.50.620 3 184 2.9E-34 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS32720 829936588d15d69913024d0c5b88db5b 320 ProSitePatterns PS00696 Electron transfer flavoprotein alpha-subunit signature. 259 285 - T 09-03-2017 IPR018206 Electron transfer flavoprotein subunit alpha, conserved site Reactome: R-HSA-611105 TK78_RS32720 829936588d15d69913024d0c5b88db5b 320 PIRSF PIRSF000089 1 320 1.2E-95 T 09-03-2017 IPR001308 Electron transfer flavoprotein alpha subunit/FixB GO:0009055|GO:0050660 Reactome: R-HSA-611105 TK78_RS32720 829936588d15d69913024d0c5b88db5b 320 Pfam PF00766 Electron transfer flavoprotein FAD-binding domain 196 278 8.9E-36 T 09-03-2017 IPR014731 Electron transfer flavoprotein, alpha subunit, C-terminal Reactome: R-HSA-611105 TK78_RS32720 829936588d15d69913024d0c5b88db5b 320 Pfam PF01012 Electron transfer flavoprotein domain 4 172 7.3E-25 T 09-03-2017 IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal Reactome: R-HSA-611105 TK78_RS32720 829936588d15d69913024d0c5b88db5b 320 SMART SM00893 4 183 5.4E-14 T 09-03-2017 IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal Reactome: R-HSA-611105 TK78_RS32720 829936588d15d69913024d0c5b88db5b 320 SUPERFAMILY SSF52467 194 315 2.19E-46 T 09-03-2017 IPR029035 DHS-like NAD/FAD-binding domain TK78_RS22220 362810cd407dfa2e80dc21ec637796ab 428 SUPERFAMILY SSF161098 47 137 2.76E-46 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS22220 362810cd407dfa2e80dc21ec637796ab 428 SUPERFAMILY SSF161098 280 416 2.76E-46 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS22220 362810cd407dfa2e80dc21ec637796ab 428 Gene3D G3DSA:1.10.3720.10 283 419 6.7E-67 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS22220 362810cd407dfa2e80dc21ec637796ab 428 Gene3D G3DSA:1.10.3720.10 5 130 6.7E-67 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS22220 362810cd407dfa2e80dc21ec637796ab 428 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 284 413 3.0E-19 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS22220 362810cd407dfa2e80dc21ec637796ab 428 SUPERFAMILY SSF160964 3 51 9.94E-7 T 09-03-2017 TK78_RS25545 bcb3df94ce9ea043293bffc2ac1de325 804 Pfam PF08924 Domain of unknown function (DUF1906) 312 438 1.5E-35 T 09-03-2017 IPR015020 Protein of unknown function DUF1906 TK78_RS25545 bcb3df94ce9ea043293bffc2ac1de325 804 Gene3D G3DSA:1.10.101.10 256 290 5.2E-4 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS25545 bcb3df94ce9ea043293bffc2ac1de325 804 Gene3D G3DSA:3.20.20.80 300 491 5.0E-50 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS25545 bcb3df94ce9ea043293bffc2ac1de325 804 Pfam PF01471 Putative peptidoglycan binding domain 256 289 4.7E-6 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS25545 bcb3df94ce9ea043293bffc2ac1de325 804 SUPERFAMILY SSF47090 251 293 2.67E-6 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS25545 bcb3df94ce9ea043293bffc2ac1de325 804 SUPERFAMILY SSF47090 76 133 8.32E-6 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS25545 bcb3df94ce9ea043293bffc2ac1de325 804 SUPERFAMILY SSF51445 300 485 1.97E-36 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS08635 9b7b0b22749542ebf93999effa6afe7b 471 Gene3D G3DSA:3.20.20.80 19 463 2.5E-151 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS08635 9b7b0b22749542ebf93999effa6afe7b 471 TIGRFAM TIGR03356 BGL: beta-galactosidase 20 458 5.2E-178 T 09-03-2017 IPR017736 Glycoside hydrolase, family 1, beta-glucosidase GO:0008422|GO:0030245 KEGG: 00460+3.2.1.21|KEGG: 00500+3.2.1.21|KEGG: 00940+3.2.1.21|MetaCyc: PWY-3121|MetaCyc: PWY-5176|MetaCyc: PWY-6002|MetaCyc: PWY-6788|MetaCyc: PWY-7089|MetaCyc: PWY-7091|MetaCyc: PWY-7092 TK78_RS08635 9b7b0b22749542ebf93999effa6afe7b 471 Pfam PF00232 Glycosyl hydrolase family 1 19 463 7.8E-151 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS08635 9b7b0b22749542ebf93999effa6afe7b 471 ProSitePatterns PS00653 Glycosyl hydrolases family 1 N-terminal signature. 23 37 - T 09-03-2017 IPR033132 Glycosyl hydrolases family 1, N-terminal conserved site TK78_RS08635 9b7b0b22749542ebf93999effa6afe7b 471 ProSitePatterns PS00572 Glycosyl hydrolases family 1 active site. 370 378 - T 09-03-2017 IPR018120 Glycoside hydrolase family 1, active site TK78_RS08635 9b7b0b22749542ebf93999effa6afe7b 471 PRINTS PR00131 Glycosyl hydrolase family 1 signature 302 316 9.3E-18 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS08635 9b7b0b22749542ebf93999effa6afe7b 471 PRINTS PR00131 Glycosyl hydrolase family 1 signature 412 429 9.3E-18 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS08635 9b7b0b22749542ebf93999effa6afe7b 471 PRINTS PR00131 Glycosyl hydrolase family 1 signature 370 378 9.3E-18 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS08635 9b7b0b22749542ebf93999effa6afe7b 471 PRINTS PR00131 Glycosyl hydrolase family 1 signature 391 402 9.3E-18 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS08635 9b7b0b22749542ebf93999effa6afe7b 471 PRINTS PR00131 Glycosyl hydrolase family 1 signature 436 448 9.3E-18 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS08635 9b7b0b22749542ebf93999effa6afe7b 471 SUPERFAMILY SSF51445 18 463 8.0E-152 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS07670 2e4435ca1a5b7086d07a810fb397ab11 459 Pfam PF05193 Peptidase M16 inactive domain 199 380 1.1E-43 T 09-03-2017 IPR007863 Peptidase M16, C-terminal TK78_RS07670 2e4435ca1a5b7086d07a810fb397ab11 459 Pfam PF00675 Insulinase (Peptidase family M16) 45 192 3.4E-36 T 09-03-2017 IPR011765 Peptidase M16, N-terminal TK78_RS07670 2e4435ca1a5b7086d07a810fb397ab11 459 Gene3D G3DSA:3.30.830.10 35 240 7.0E-55 T 09-03-2017 IPR011237 Peptidase M16 domain GO:0046872 TK78_RS07670 2e4435ca1a5b7086d07a810fb397ab11 459 SUPERFAMILY SSF63411 34 238 5.32E-58 T 09-03-2017 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 TK78_RS07670 2e4435ca1a5b7086d07a810fb397ab11 459 SUPERFAMILY SSF63411 265 450 3.19E-47 T 09-03-2017 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 TK78_RS07670 2e4435ca1a5b7086d07a810fb397ab11 459 ProSitePatterns PS00143 Insulinase family, zinc-binding region signature. 66 89 - T 09-03-2017 IPR001431 Peptidase M16, zinc-binding site GO:0004222|GO:0006508 TK78_RS07670 2e4435ca1a5b7086d07a810fb397ab11 459 Gene3D G3DSA:3.30.830.10 269 448 1.6E-56 T 09-03-2017 IPR011237 Peptidase M16 domain GO:0046872 TK78_RS33575 c4fdb10dd58ddc5691f56e384bc337b1 1168 Pfam PF14579 Helix-hairpin-helix motif 818 902 4.3E-17 T 09-03-2017 IPR029460 DNA polymerase, helix-hairpin-helix motif KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS33575 c4fdb10dd58ddc5691f56e384bc337b1 1168 Gene3D G3DSA:3.20.20.140 3 67 2.9E-8 T 09-03-2017 TK78_RS33575 c4fdb10dd58ddc5691f56e384bc337b1 1168 SUPERFAMILY SSF89550 10 67 7.65E-7 T 09-03-2017 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 TK78_RS33575 c4fdb10dd58ddc5691f56e384bc337b1 1168 Pfam PF07733 Bacterial DNA polymerase III alpha subunit 341 740 1.4E-108 T 09-03-2017 IPR011708 Bacterial DNA polymerase III, alpha subunit GO:0006260|GO:0008408 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS33575 c4fdb10dd58ddc5691f56e384bc337b1 1168 Pfam PF02811 PHP domain 5 163 1.4E-15 T 09-03-2017 IPR004013 PHP domain GO:0003824 TK78_RS33575 c4fdb10dd58ddc5691f56e384bc337b1 1168 TIGRFAM TIGR00594 polc: DNA polymerase III, alpha subunit 3 1047 1.9E-151 T 09-03-2017 IPR004805 DNA polymerase III, alpha subunit GO:0006260|GO:0008408 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS33575 c4fdb10dd58ddc5691f56e384bc337b1 1168 SMART SM00481 4 71 1.8E-18 T 09-03-2017 IPR003141 Polymerase/histidinol phosphatase, N-terminal GO:0003677|GO:0003887|GO:0006260 TK78_RS01405 344c49c885bdfe7a49132452a1fcfb62 335 Pfam PF14716 Helix-hairpin-helix domain 5 69 6.0E-13 T 09-03-2017 IPR010996 DNA polymerase beta-like, N-terminal domain TK78_RS01405 344c49c885bdfe7a49132452a1fcfb62 335 Pfam PF02811 PHP domain 103 189 9.4E-6 T 09-03-2017 IPR004013 PHP domain GO:0003824 TK78_RS01405 344c49c885bdfe7a49132452a1fcfb62 335 SUPERFAMILY SSF89550 102 332 3.4E-47 T 09-03-2017 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 TK78_RS01405 344c49c885bdfe7a49132452a1fcfb62 335 Gene3D G3DSA:1.10.150.110 4 82 9.7E-10 T 09-03-2017 IPR027421 DNA polymerase family X lyase domain TK78_RS01405 344c49c885bdfe7a49132452a1fcfb62 335 PIRSF PIRSF036978 1 335 2.4E-171 T 09-03-2017 IPR017078 Uncharacterised conserved protein UCP036978, histidinol phosphatase-related hydrolase, SCO0789 TK78_RS01405 344c49c885bdfe7a49132452a1fcfb62 335 SMART SM00481 102 181 1.6E-17 T 09-03-2017 IPR003141 Polymerase/histidinol phosphatase, N-terminal GO:0003677|GO:0003887|GO:0006260 TK78_RS01405 344c49c885bdfe7a49132452a1fcfb62 335 Gene3D G3DSA:3.20.20.140 102 333 1.0E-45 T 09-03-2017 TK78_RS01405 344c49c885bdfe7a49132452a1fcfb62 335 SUPERFAMILY SSF47802 3 82 7.98E-11 T 09-03-2017 IPR010996 DNA polymerase beta-like, N-terminal domain TK78_RS24460 62e09922092f154daeaa0bcf43f83150 740 Gene3D G3DSA:3.90.1310.10 137 259 3.7E-30 T 09-03-2017 TK78_RS24460 62e09922092f154daeaa0bcf43f83150 740 Gene3D G3DSA:3.40.710.10 261 473 2.2E-90 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS24460 62e09922092f154daeaa0bcf43f83150 740 Gene3D G3DSA:3.40.710.10 511 663 2.2E-90 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS24460 62e09922092f154daeaa0bcf43f83150 740 TIGRFAM TIGR03423 pbp2_mrdA: penicillin-binding protein 2 16 662 1.1E-176 T 09-03-2017 IPR017790 Penicillin-binding protein 2 GO:0016020 TK78_RS24460 62e09922092f154daeaa0bcf43f83150 740 SUPERFAMILY SSF56519 53 261 3.27E-35 T 09-03-2017 IPR005311 Penicillin-binding protein, dimerisation domain GO:0008658 TK78_RS24460 62e09922092f154daeaa0bcf43f83150 740 SUPERFAMILY SSF56601 213 459 3.02E-85 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS24460 62e09922092f154daeaa0bcf43f83150 740 SUPERFAMILY SSF56601 516 665 3.02E-85 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS24460 62e09922092f154daeaa0bcf43f83150 740 Pfam PF03717 Penicillin-binding Protein dimerisation domain 60 246 7.1E-38 T 09-03-2017 IPR005311 Penicillin-binding protein, dimerisation domain GO:0008658 TK78_RS24460 62e09922092f154daeaa0bcf43f83150 740 Pfam PF00905 Penicillin binding protein transpeptidase domain 298 659 1.3E-80 T 09-03-2017 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 TK78_RS05505 a94c4595a60137e49a470d41b4b6d8d1 263 SUPERFAMILY SSF52540 21 236 2.54E-61 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS05505 a94c4595a60137e49a470d41b4b6d8d1 263 ProSitePatterns PS00211 ABC transporters family signature. 143 157 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS05505 a94c4595a60137e49a470d41b4b6d8d1 263 Gene3D G3DSA:3.40.50.300 15 230 2.7E-62 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS05505 a94c4595a60137e49a470d41b4b6d8d1 263 Pfam PF00005 ABC transporter 38 171 2.5E-28 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS05505 a94c4595a60137e49a470d41b4b6d8d1 263 SMART SM00382 47 221 7.7E-14 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS26485 f86d90c8fe1552e89f7d2c44a7978b4b 174 SUPERFAMILY SSF69118 29 165 1.96E-40 T 09-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 TK78_RS26485 f86d90c8fe1552e89f7d2c44a7978b4b 174 Gene3D G3DSA:1.20.1290.10 28 166 2.9E-46 T 09-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 TK78_RS26485 f86d90c8fe1552e89f7d2c44a7978b4b 174 TIGRFAM TIGR00778 ahpD_dom: alkylhydroperoxidase AhpD family core domain 53 101 2.0E-18 T 09-03-2017 IPR004675 Alkylhydroperoxidase AhpD core GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 TK78_RS26485 f86d90c8fe1552e89f7d2c44a7978b4b 174 Pfam PF02627 Carboxymuconolactone decarboxylase family 37 118 8.8E-19 T 09-03-2017 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 TK78_RS20435 dfaa6b3d24f4a1f2172d7feb55f4122e 279 SUPERFAMILY SSF51430 8 275 2.75E-73 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS20435 dfaa6b3d24f4a1f2172d7feb55f4122e 279 PRINTS PR00069 Aldo-keto reductase signature 139 156 4.0E-8 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS20435 dfaa6b3d24f4a1f2172d7feb55f4122e 279 PRINTS PR00069 Aldo-keto reductase signature 42 66 4.0E-8 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS20435 dfaa6b3d24f4a1f2172d7feb55f4122e 279 PRINTS PR00069 Aldo-keto reductase signature 209 233 4.0E-8 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS20435 dfaa6b3d24f4a1f2172d7feb55f4122e 279 PRINTS PR00069 Aldo-keto reductase signature 108 126 4.0E-8 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS20435 dfaa6b3d24f4a1f2172d7feb55f4122e 279 Gene3D G3DSA:3.20.20.100 11 276 1.7E-71 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS20435 dfaa6b3d24f4a1f2172d7feb55f4122e 279 Pfam PF00248 Aldo/keto reductase family 16 274 8.7E-58 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS14670 31510caffa68947a3cb35284f34c523e 298 Gene3D G3DSA:1.10.357.10 211 296 8.3E-4 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS14670 31510caffa68947a3cb35284f34c523e 298 Gene3D G3DSA:3.40.190.10 97 197 1.6E-13 T 09-03-2017 TK78_RS14670 31510caffa68947a3cb35284f34c523e 298 Hamap MF_00996 1,4-dihydroxy-6-naphtoate synthase [mqnD]. 21 288 40.397 T 09-03-2017 IPR030869 1,4-dihydroxy-6-naphtoate synthase GO:0009234|GO:0016829 TK78_RS14670 31510caffa68947a3cb35284f34c523e 298 Pfam PF02621 Menaquinone biosynthesis 22 282 1.8E-88 T 09-03-2017 IPR003773 Menaquinone biosynthesis enzyme TK78_RS14670 31510caffa68947a3cb35284f34c523e 298 SUPERFAMILY SSF53850 22 287 1.03E-81 T 09-03-2017 TK78_RS30530 78c574e81dc2d187220b5517120906f2 199 Pfam PF04978 Protein of unknown function (DUF664) 10 160 1.5E-44 T 09-03-2017 IPR007061 Protein of unknown function DUF664 TK78_RS30530 78c574e81dc2d187220b5517120906f2 199 Gene3D G3DSA:1.20.120.450 8 163 1.3E-30 T 09-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase TK78_RS30530 78c574e81dc2d187220b5517120906f2 199 SUPERFAMILY SSF109854 7 159 1.98E-34 T 09-03-2017 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SUPERFAMILY SSF51735 2986 3161 3.39E-34 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SMART SM01294 3462 3529 7.7E-4 T 09-03-2017 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SMART SM01294 1739 1806 2.4E-5 T 09-03-2017 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Gene3D G3DSA:3.40.47.10 298 460 1.5E-62 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Gene3D G3DSA:3.40.47.10 2080 2247 2.8E-67 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Pfam PF00698 Acyl transferase domain 593 908 3.2E-66 T 09-03-2017 IPR014043 Acyl transferase TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Pfam PF00698 Acyl transferase domain 2353 2665 9.2E-61 T 09-03-2017 IPR014043 Acyl transferase TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SUPERFAMILY SSF47336 3453 3539 8.11E-19 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SUPERFAMILY SSF51735 1400 1436 1.85E-18 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SUPERFAMILY SSF51735 1246 1364 1.85E-18 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Pfam PF14765 Polyketide synthase dehydratase 955 1232 1.4E-55 T 09-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Pfam PF14765 Polyketide synthase dehydratase 2704 2976 7.1E-62 T 09-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 198 214 - T 09-03-2017 IPR018201 Beta-ketoacyl synthase, active site TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1831 2067 3.6E-81 T 09-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 34 285 7.1E-84 T 09-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Gene3D G3DSA:1.10.1200.10 3457 3534 1.0E-17 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Gene3D G3DSA:1.10.1200.10 1736 1812 1.0E-21 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SUPERFAMILY SSF55048 717 778 1.96E-13 T 09-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Gene3D G3DSA:3.40.50.720 3174 3375 7.2E-38 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Gene3D G3DSA:3.40.50.720 1454 1650 3.2E-35 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Gene3D G3DSA:3.40.366.10 2538 2661 5.8E-81 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Gene3D G3DSA:3.40.366.10 2347 2477 5.8E-81 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 293 410 1.5E-42 T 09-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 2075 2192 2.7E-45 T 09-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Pfam PF00550 Phosphopantetheine attachment site 1741 1806 1.3E-11 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Pfam PF00550 Phosphopantetheine attachment site 3464 3529 4.0E-10 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Gene3D G3DSA:3.40.366.10 778 892 3.0E-80 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Gene3D G3DSA:3.40.366.10 587 712 3.0E-80 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SUPERFAMILY SSF51735 1454 1648 1.83E-42 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SMART SM00826 955 1123 9.6E-80 T 09-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SMART SM00826 2704 2867 2.0E-86 T 09-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SUPERFAMILY SSF51735 3173 3385 1.13E-44 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Gene3D G3DSA:3.40.47.10 1833 2079 1.1E-82 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Gene3D G3DSA:3.40.47.10 36 297 7.7E-86 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SUPERFAMILY SSF55048 2481 2538 6.54E-10 T 09-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Pfam PF08659 KR domain 3175 3353 2.9E-57 T 09-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Pfam PF08659 KR domain 1454 1630 1.1E-57 T 09-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Pfam PF08990 Erythronolide synthase docking 2 27 7.5E-10 T 09-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Gene3D G3DSA:3.30.70.250 2481 2531 5.1E-7 T 09-03-2017 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Gene3D G3DSA:3.30.70.250 716 777 3.8E-9 T 09-03-2017 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SMART SM00823 Phosphopantetheine attachment site 3461 3533 5.5E-25 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SMART SM00823 Phosphopantetheine attachment site 1738 1810 1.1E-28 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SUPERFAMILY SSF52151 2539 2632 2.38E-76 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SUPERFAMILY SSF52151 2351 2482 2.38E-76 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 594 888 4.6E-130 T 09-03-2017 IPR020801 Polyketide synthase, acyl transferase domain TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2354 2647 2.2E-123 T 09-03-2017 IPR020801 Polyketide synthase, acyl transferase domain TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SUPERFAMILY SSF53901 31 154 1.24E-98 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SUPERFAMILY SSF53901 181 407 1.24E-98 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SUPERFAMILY SSF53901 1828 2190 3.06E-104 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SUPERFAMILY SSF52151 779 879 9.42E-72 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SUPERFAMILY SSF52151 591 718 9.42E-72 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SUPERFAMILY SSF47336 1733 1846 3.53E-24 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1765 1780 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 3175 3355 4.3E-60 T 09-03-2017 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1454 1632 5.5E-55 T 09-03-2017 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 413 528 4.1E-9 T 09-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 2195 2317 2.8E-14 T 09-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1980 1996 - T 09-03-2017 IPR018201 Beta-ketoacyl synthase, active site TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SMART SM00825 Beta-ketoacyl synthase 1833 2245 1.4E-213 T 09-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TK78_RS07105 09f870971a84563ed003fb0ef8e52e24 3620 SMART SM00825 Beta-ketoacyl synthase 36 463 6.1E-201 T 09-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TK78_RS19490 a3d18346d63aa6796e9d4207c34856b1 169 Pfam PF04542 Sigma-70 region 2 29 79 3.3E-8 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS19490 a3d18346d63aa6796e9d4207c34856b1 169 Gene3D G3DSA:1.10.1740.10 5 79 1.6E-11 T 09-03-2017 TK78_RS19490 a3d18346d63aa6796e9d4207c34856b1 169 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 28 159 5.6E-17 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS19490 a3d18346d63aa6796e9d4207c34856b1 169 TIGRFAM TIGR02983 SigE-fam_strep: RNA polymerase sigma-70 factor, sigma-E family 4 160 3.5E-47 T 09-03-2017 IPR014325 RNA polymerase sigma-E factor, actinobacteria GO:0016987 TK78_RS19490 a3d18346d63aa6796e9d4207c34856b1 169 Pfam PF08281 Sigma-70, region 4 103 155 1.8E-13 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS19490 a3d18346d63aa6796e9d4207c34856b1 169 Gene3D G3DSA:1.10.10.10 97 161 1.7E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS19490 a3d18346d63aa6796e9d4207c34856b1 169 SUPERFAMILY SSF88659 88 161 1.5E-14 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS19490 a3d18346d63aa6796e9d4207c34856b1 169 SUPERFAMILY SSF88946 18 94 7.85E-11 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS10840 60cd9785f102436b560853e94777fad1 364 Gene3D G3DSA:3.40.640.10 43 240 1.0E-41 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS10840 60cd9785f102436b560853e94777fad1 364 TIGRFAM TIGR03539 DapC_actino: succinyldiaminopimelate transaminase 8 363 5.2E-184 T 09-03-2017 IPR019880 Succinyldiaminopimelate transaminase, DapC, actinobacteria TK78_RS10840 60cd9785f102436b560853e94777fad1 364 Pfam PF00155 Aminotransferase class I and II 30 363 1.9E-42 T 09-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TK78_RS10840 60cd9785f102436b560853e94777fad1 364 SUPERFAMILY SSF53383 5 363 1.36E-79 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS10840 60cd9785f102436b560853e94777fad1 364 Gene3D G3DSA:3.90.1150.10 241 363 1.3E-21 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS30575 d4ba767fde2940446472ae4e156ba268 124 Hamap MF_01483 RNA polymerase-binding protein RbpA [rbpA]. 16 120 26.466 T 09-03-2017 IPR025182 RNA polymerase-binding protein RbpA GO:0001000|GO:0045893 TK78_RS30575 d4ba767fde2940446472ae4e156ba268 124 Pfam PF13397 RNA polymerase-binding protein 4 107 7.8E-42 T 09-03-2017 IPR025182 RNA polymerase-binding protein RbpA GO:0001000|GO:0045893 TK78_RS08850 e8ab9b257bcab1a9d365aef686b67a23 500 ProSitePatterns PS00571 Amidases signature. 156 187 - T 09-03-2017 IPR020556 Amidase, conserved site KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921|Reactome: R-HSA-2142753 TK78_RS08850 e8ab9b257bcab1a9d365aef686b67a23 500 SUPERFAMILY SSF75304 5 484 2.22E-159 T 09-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 TK78_RS08850 e8ab9b257bcab1a9d365aef686b67a23 500 Gene3D G3DSA:3.90.1300.10 6 487 6.0E-174 T 09-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 TK78_RS08850 e8ab9b257bcab1a9d365aef686b67a23 500 Hamap MF_00120 Glutamyl-tRNA(Gln) amidotransferase subunit A [gatA]. 15 486 89.678 T 09-03-2017 IPR004412 Glutamyl-tRNA(Gln) amidotransferase A subunit GO:0006412 KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 TK78_RS08850 e8ab9b257bcab1a9d365aef686b67a23 500 TIGRFAM TIGR00132 gatA: aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, A subunit 19 485 1.3E-184 T 09-03-2017 IPR004412 Glutamyl-tRNA(Gln) amidotransferase A subunit GO:0006412 KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 TK78_RS08850 e8ab9b257bcab1a9d365aef686b67a23 500 Pfam PF01425 Amidase 28 474 1.1E-156 T 09-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 TK78_RS19450 ab2df6c5f5ae00abd13b8df2aff59c54 308 ProSitePatterns PS00583 pfkB family of carbohydrate kinases signature 1. 36 60 - T 09-03-2017 IPR002173 Carbohydrate/puine kinase, PfkB, conserved site GO:0016773 TK78_RS19450 ab2df6c5f5ae00abd13b8df2aff59c54 308 PIRSF PIRSF000535 1 304 3.9E-81 T 09-03-2017 IPR017583 Tagatose/fructose phosphokinase GO:0005975|GO:0016773 TK78_RS19450 ab2df6c5f5ae00abd13b8df2aff59c54 308 Gene3D G3DSA:3.40.1190.20 34 302 1.0E-81 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS19450 ab2df6c5f5ae00abd13b8df2aff59c54 308 Pfam PF00294 pfkB family carbohydrate kinase 12 285 1.4E-43 T 09-03-2017 IPR011611 Carbohydrate kinase PfkB TK78_RS19450 ab2df6c5f5ae00abd13b8df2aff59c54 308 ProSitePatterns PS00584 pfkB family of carbohydrate kinases signature 2. 242 255 - T 09-03-2017 IPR002173 Carbohydrate/puine kinase, PfkB, conserved site GO:0016773 TK78_RS19450 ab2df6c5f5ae00abd13b8df2aff59c54 308 SUPERFAMILY SSF53613 2 285 6.55E-64 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS19450 ab2df6c5f5ae00abd13b8df2aff59c54 308 TIGRFAM TIGR03168 1-PFK: hexose kinase, 1-phosphofructokinase family 2 302 1.2E-92 T 09-03-2017 IPR017583 Tagatose/fructose phosphokinase GO:0005975|GO:0016773 TK78_RS30510 c29326e321f3641bb75d557d1f76f79b 209 SUPERFAMILY SSF52540 22 176 1.61E-15 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS30510 c29326e321f3641bb75d557d1f76f79b 209 Gene3D G3DSA:3.40.50.300 19 178 2.1E-20 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13670 d1ed3eb03f48b59432104f2d916cfacc 283 Pfam PF00877 NlpC/P60 family 181 263 1.0E-20 T 09-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain TK78_RS13670 d1ed3eb03f48b59432104f2d916cfacc 283 Gene3D G3DSA:3.90.1720.10 163 283 1.7E-38 T 09-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain TK78_RS13670 d1ed3eb03f48b59432104f2d916cfacc 283 SUPERFAMILY SSF54001 163 282 1.08E-37 T 09-03-2017 TK78_RS27955 2e907a27e92acd8cf4bfcfcfb94b2215 378 Pfam PF04909 Amidohydrolase 196 377 7.6E-7 T 09-03-2017 IPR006680 Amidohydrolase-related GO:0016787 TK78_RS27955 2e907a27e92acd8cf4bfcfcfb94b2215 378 Gene3D G3DSA:3.20.20.140 5 378 1.9E-97 T 09-03-2017 TK78_RS27955 2e907a27e92acd8cf4bfcfcfb94b2215 378 SUPERFAMILY SSF51556 203 377 1.9E-7 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS12740 03d0cd9e03e3b8aaa63edd201c894555 532 SUPERFAMILY SSF50998 168 470 8.04E-19 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS12740 03d0cd9e03e3b8aaa63edd201c894555 532 Gene3D G3DSA:2.140.10.10 73 455 2.4E-16 T 09-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain TK78_RS12740 03d0cd9e03e3b8aaa63edd201c894555 532 Pfam PF13360 PQQ-like domain 155 278 1.9E-9 T 09-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat TK78_RS04665 2767fad7f517853df4585a6916af89c6 515 Pfam PF02133 Permease for cytosine/purines, uracil, thiamine, allantoin 45 492 1.9E-140 T 09-03-2017 IPR001248 Purine-cytosine permease GO:0005215|GO:0016020|GO:0055085 TK78_RS04665 2767fad7f517853df4585a6916af89c6 515 TIGRFAM TIGR00800 ncs1: NCS1 nucleoside transporter family 40 461 6.2E-135 T 09-03-2017 IPR012681 Nucleobase cation symporter-1, NCS1 GO:0005215|GO:0006810|GO:0016020 TK78_RS07160 e70a698cae098b10c21976135e8d1bc7 216 SMART SM00382 1 143 0.006 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS07160 e70a698cae098b10c21976135e8d1bc7 216 Gene3D G3DSA:3.30.60.20 144 195 1.6E-6 T 09-03-2017 TK78_RS07160 e70a698cae098b10c21976135e8d1bc7 216 PIRSF PIRSF035805 1 204 8.7E-38 T 09-03-2017 IPR001267 Thymidine kinase GO:0004797|GO:0005524 KEGG: 00240+2.7.1.21|KEGG: 00983+2.7.1.21|MetaCyc: PWY-7199|Reactome: R-HSA-73614 TK78_RS07160 e70a698cae098b10c21976135e8d1bc7 216 SUPERFAMILY SSF57716 144 197 1.38E-9 T 09-03-2017 TK78_RS07160 e70a698cae098b10c21976135e8d1bc7 216 Gene3D G3DSA:3.40.50.300 2 118 1.7E-7 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07160 e70a698cae098b10c21976135e8d1bc7 216 Pfam PF00265 Thymidine kinase 4 192 2.2E-26 T 09-03-2017 IPR001267 Thymidine kinase GO:0004797|GO:0005524 KEGG: 00240+2.7.1.21|KEGG: 00983+2.7.1.21|MetaCyc: PWY-7199|Reactome: R-HSA-73614 TK78_RS07160 e70a698cae098b10c21976135e8d1bc7 216 SUPERFAMILY SSF52540 1 140 2.47E-28 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07160 e70a698cae098b10c21976135e8d1bc7 216 Hamap MF_00124 Thymidine kinase [tdk]. 1 195 28.453 T 09-03-2017 IPR001267 Thymidine kinase GO:0004797|GO:0005524 KEGG: 00240+2.7.1.21|KEGG: 00983+2.7.1.21|MetaCyc: PWY-7199|Reactome: R-HSA-73614 TK78_RS22215 a93b52fc9ca300a8285b747ff4bb5bfa 314 SUPERFAMILY SSF161098 46 314 1.87E-65 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS22215 a93b52fc9ca300a8285b747ff4bb5bfa 314 Gene3D G3DSA:1.10.3720.10 46 302 1.6E-56 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS22215 a93b52fc9ca300a8285b747ff4bb5bfa 314 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 126 299 1.2E-15 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS32095 1d7e08949cf2924394cbe6c3f3e9f573 546 Gene3D G3DSA:3.40.50.300 275 520 1.3E-45 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS32095 1d7e08949cf2924394cbe6c3f3e9f573 546 Gene3D G3DSA:3.40.50.300 21 243 3.8E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS32095 1d7e08949cf2924394cbe6c3f3e9f573 546 ProSitePatterns PS00211 ABC transporters family signature. 429 443 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS32095 1d7e08949cf2924394cbe6c3f3e9f573 546 SUPERFAMILY SSF52540 21 245 1.04E-52 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS32095 1d7e08949cf2924394cbe6c3f3e9f573 546 SUPERFAMILY SSF52540 268 515 1.17E-42 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS32095 1d7e08949cf2924394cbe6c3f3e9f573 546 SMART SM00382 46 236 2.4E-9 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS32095 1d7e08949cf2924394cbe6c3f3e9f573 546 SMART SM00382 309 507 0.0014 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS32095 1d7e08949cf2924394cbe6c3f3e9f573 546 Pfam PF00005 ABC transporter 37 188 9.3E-26 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS32095 1d7e08949cf2924394cbe6c3f3e9f573 546 Pfam PF00005 ABC transporter 301 456 2.0E-16 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS12085 116186949f4c5a4b7300617de17935b7 228 SUPERFAMILY SSF52172 7 175 8.5E-41 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS12085 116186949f4c5a4b7300617de17935b7 228 Pfam PF00486 Transcriptional regulatory protein, C terminal 148 224 1.2E-24 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS12085 116186949f4c5a4b7300617de17935b7 228 Gene3D G3DSA:3.40.50.2300 7 126 3.5E-41 T 09-03-2017 TK78_RS12085 116186949f4c5a4b7300617de17935b7 228 SMART SM00448 5 115 1.5E-40 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS12085 116186949f4c5a4b7300617de17935b7 228 Pfam PF00072 Response regulator receiver domain 8 115 6.9E-29 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS12085 116186949f4c5a4b7300617de17935b7 228 SMART SM00862 148 224 1.0E-22 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS12085 116186949f4c5a4b7300617de17935b7 228 Gene3D G3DSA:1.10.10.10 127 226 2.9E-32 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS01255 08b999cc928248327d045f6c3e1124f4 297 Gene3D G3DSA:3.40.50.1980 139 293 1.9E-19 T 09-03-2017 TK78_RS01255 08b999cc928248327d045f6c3e1124f4 297 Pfam PF01497 Periplasmic binding protein 40 268 6.3E-20 T 09-03-2017 IPR002491 ABC transporter periplasmic binding domain GO:0005488 TK78_RS01255 08b999cc928248327d045f6c3e1124f4 297 Gene3D G3DSA:3.40.50.1980 20 138 2.9E-24 T 09-03-2017 TK78_RS01255 08b999cc928248327d045f6c3e1124f4 297 SUPERFAMILY SSF53807 29 296 3.92E-42 T 09-03-2017 TK78_RS08265 ca45f2e114bb7fa58f4634ac0c81c625 274 SUPERFAMILY SSF69065 14 175 3.84E-49 T 09-03-2017 IPR000999 Ribonuclease III domain GO:0004525|GO:0006396 TK78_RS08265 ca45f2e114bb7fa58f4634ac0c81c625 274 Pfam PF14622 Ribonuclease-III-like 33 158 2.1E-38 T 09-03-2017 IPR000999 Ribonuclease III domain GO:0004525|GO:0006396 TK78_RS08265 ca45f2e114bb7fa58f4634ac0c81c625 274 Hamap MF_00104 Ribonuclease 3 [rnc]. 23 236 30.531 T 09-03-2017 IPR011907 Ribonuclease III GO:0003723|GO:0004525|GO:0016075 Reactome: R-HSA-203927 TK78_RS08265 ca45f2e114bb7fa58f4634ac0c81c625 274 SMART SM00535 34 167 6.5E-62 T 09-03-2017 IPR000999 Ribonuclease III domain GO:0004525|GO:0006396 TK78_RS08265 ca45f2e114bb7fa58f4634ac0c81c625 274 ProSitePatterns PS00517 Ribonuclease III family signature. 56 64 - T 09-03-2017 IPR000999 Ribonuclease III domain GO:0004525|GO:0006396 TK78_RS08265 ca45f2e114bb7fa58f4634ac0c81c625 274 SUPERFAMILY SSF54768 128 239 1.16E-25 T 09-03-2017 TK78_RS08265 ca45f2e114bb7fa58f4634ac0c81c625 274 Pfam PF00035 Double-stranded RNA binding motif 174 238 1.3E-16 T 09-03-2017 IPR014720 Double-stranded RNA-binding domain TK78_RS08265 ca45f2e114bb7fa58f4634ac0c81c625 274 Gene3D G3DSA:3.30.160.20 172 239 5.5E-26 T 09-03-2017 IPR014720 Double-stranded RNA-binding domain TK78_RS08265 ca45f2e114bb7fa58f4634ac0c81c625 274 SMART SM00358 174 240 3.9E-23 T 09-03-2017 IPR014720 Double-stranded RNA-binding domain TK78_RS08265 ca45f2e114bb7fa58f4634ac0c81c625 274 Gene3D G3DSA:1.10.1520.10 23 163 2.0E-46 T 09-03-2017 IPR000999 Ribonuclease III domain GO:0004525|GO:0006396 TK78_RS08265 ca45f2e114bb7fa58f4634ac0c81c625 274 TIGRFAM TIGR02191 RNaseIII: ribonuclease III 26 238 1.2E-72 T 09-03-2017 IPR011907 Ribonuclease III GO:0003723|GO:0004525|GO:0016075 Reactome: R-HSA-203927 TK78_RS20215 fe8f123997f031d64a789d75a4c5d985 423 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 228 264 - T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS20215 fe8f123997f031d64a789d75a4c5d985 423 TIGRFAM TIGR00713 hemL: glutamate-1-semialdehyde-2,1-aminomutase 1 411 7.2E-179 T 09-03-2017 IPR004639 Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase GO:0033014|GO:0042286 KEGG: 00860+5.4.3.8|MetaCyc: PWY-5188 TK78_RS20215 fe8f123997f031d64a789d75a4c5d985 423 Gene3D G3DSA:3.40.640.10 64 310 1.3E-75 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS20215 fe8f123997f031d64a789d75a4c5d985 423 Hamap MF_00375 Glutamate-1-semialdehyde 2,1-aminomutase [hemL]. 1 418 95.897 T 09-03-2017 IPR004639 Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase GO:0033014|GO:0042286 KEGG: 00860+5.4.3.8|MetaCyc: PWY-5188 TK78_RS20215 fe8f123997f031d64a789d75a4c5d985 423 Gene3D G3DSA:3.90.1150.10 312 414 5.2E-37 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS20215 fe8f123997f031d64a789d75a4c5d985 423 Gene3D G3DSA:3.90.1150.10 1 63 5.2E-37 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS20215 fe8f123997f031d64a789d75a4c5d985 423 Pfam PF00202 Aminotransferase class-III 27 411 2.6E-77 T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS20215 fe8f123997f031d64a789d75a4c5d985 423 SUPERFAMILY SSF53383 1 414 1.58E-115 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS14175 03d6dceec4c8527f9d6977b80a67798a 193 Pfam PF13023 HD domain 16 167 2.1E-26 T 09-03-2017 IPR006674 HD domain TK78_RS14175 03d6dceec4c8527f9d6977b80a67798a 193 SMART SM00471 33 147 0.002 T 09-03-2017 IPR003607 HD/PDEase domain TK78_RS14175 03d6dceec4c8527f9d6977b80a67798a 193 SUPERFAMILY SSF109604 9 161 4.08E-33 T 09-03-2017 TK78_RS14175 03d6dceec4c8527f9d6977b80a67798a 193 Gene3D G3DSA:1.10.3210.10 6 183 6.3E-47 T 09-03-2017 IPR006674 HD domain TK78_RS06420 0e5e1a7523f81a6be8e2f3ef680982e6 495 Pfam PF13520 Amino acid permease 47 447 1.6E-56 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS06420 0e5e1a7523f81a6be8e2f3ef680982e6 495 PIRSF PIRSF006060 31 488 8.9E-89 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS18190 b825c556beb31c066244d1a696f8617f 304 Hamap MF_00137 Phosphoribosylaminoimidazole-succinocarboxamide synthase [purC]. 16 300 24.571 T 09-03-2017 IPR028923 SAICAR synthetase/ADE2, N-terminal KEGG: 00230+6.3.2.6|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TK78_RS18190 b825c556beb31c066244d1a696f8617f 304 TIGRFAM TIGR00081 purC: phosphoribosylaminoimidazolesuccinocarboxamide synthase 18 303 1.6E-67 T 09-03-2017 IPR001636 Phosphoribosylaminoimidazole-succinocarboxamide synthase GO:0004639|GO:0006164 KEGG: 00230+6.3.2.6|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234 TK78_RS18190 b825c556beb31c066244d1a696f8617f 304 SUPERFAMILY SSF56104 12 303 8.5E-95 T 09-03-2017 TK78_RS18190 b825c556beb31c066244d1a696f8617f 304 Gene3D G3DSA:3.30.200.20 11 115 3.4E-42 T 09-03-2017 TK78_RS18190 b825c556beb31c066244d1a696f8617f 304 ProSitePatterns PS01058 SAICAR synthetase signature 2. 204 212 - T 09-03-2017 IPR018236 SAICAR synthetase, conserved site GO:0004639|GO:0006164 KEGG: 00230+6.3.2.6|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TK78_RS18190 b825c556beb31c066244d1a696f8617f 304 Pfam PF01259 SAICAR synthetase 18 274 3.9E-98 T 09-03-2017 IPR028923 SAICAR synthetase/ADE2, N-terminal KEGG: 00230+6.3.2.6|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TK78_RS18190 b825c556beb31c066244d1a696f8617f 304 Gene3D G3DSA:3.30.470.20 116 252 3.5E-51 T 09-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 TK78_RS14515 f0b3989bda85c54edb01d99e51d968fb 300 Pfam PF03466 LysR substrate binding domain 89 276 1.6E-18 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS14515 f0b3989bda85c54edb01d99e51d968fb 300 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 20 31 3.0E-9 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS14515 f0b3989bda85c54edb01d99e51d968fb 300 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 31 41 3.0E-9 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS14515 f0b3989bda85c54edb01d99e51d968fb 300 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 41 52 3.0E-9 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS14515 f0b3989bda85c54edb01d99e51d968fb 300 Gene3D G3DSA:3.40.190.10 90 177 1.8E-17 T 09-03-2017 TK78_RS14515 f0b3989bda85c54edb01d99e51d968fb 300 Gene3D G3DSA:3.40.190.10 178 244 1.4E-13 T 09-03-2017 TK78_RS14515 f0b3989bda85c54edb01d99e51d968fb 300 Gene3D G3DSA:1.10.10.10 3 88 4.8E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS14515 f0b3989bda85c54edb01d99e51d968fb 300 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 5 64 3.0E-21 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS14515 f0b3989bda85c54edb01d99e51d968fb 300 SUPERFAMILY SSF53850 89 278 4.1E-20 T 09-03-2017 TK78_RS14515 f0b3989bda85c54edb01d99e51d968fb 300 SUPERFAMILY SSF46785 3 112 5.7E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS16315 946ab05bcb549c739d38b3fbbb938b0f 196 Gene3D G3DSA:3.40.50.300 19 184 8.8E-13 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS16315 946ab05bcb549c739d38b3fbbb938b0f 196 SUPERFAMILY SSF52540 19 192 5.73E-20 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS16315 946ab05bcb549c739d38b3fbbb938b0f 196 Pfam PF03029 Conserved hypothetical ATP binding protein 25 193 2.0E-21 T 09-03-2017 IPR004130 GPN-loop GTPase TK78_RS04765 4a5b7030877432bbf2eacba4d1665b8e 259 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 138 154 6.6E-33 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04765 4a5b7030877432bbf2eacba4d1665b8e 259 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 164 183 6.6E-33 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04765 4a5b7030877432bbf2eacba4d1665b8e 259 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 220 240 6.6E-33 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04765 4a5b7030877432bbf2eacba4d1665b8e 259 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 185 202 6.6E-33 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04765 4a5b7030877432bbf2eacba4d1665b8e 259 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 17 34 6.6E-33 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04765 4a5b7030877432bbf2eacba4d1665b8e 259 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 91 102 6.6E-33 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04765 4a5b7030877432bbf2eacba4d1665b8e 259 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 151 179 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS04765 4a5b7030877432bbf2eacba4d1665b8e 259 SUPERFAMILY SSF51735 14 258 4.74E-77 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS04765 4a5b7030877432bbf2eacba4d1665b8e 259 Gene3D G3DSA:3.40.50.720 8 258 1.5E-81 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS04765 4a5b7030877432bbf2eacba4d1665b8e 259 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 24 257 3.8E-57 T 09-03-2017 TK78_RS04765 4a5b7030877432bbf2eacba4d1665b8e 259 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 164 183 7.3E-7 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04765 4a5b7030877432bbf2eacba4d1665b8e 259 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 144 152 7.3E-7 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04765 4a5b7030877432bbf2eacba4d1665b8e 259 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 91 102 7.3E-7 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20835 75bb08f6280ec7e13bd18667d9197603 200 Pfam PF13247 4Fe-4S dicluster domain 48 142 3.1E-19 T 09-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TK78_RS20835 75bb08f6280ec7e13bd18667d9197603 200 Gene3D G3DSA:3.30.70.20 59 94 3.4E-12 T 09-03-2017 TK78_RS20835 75bb08f6280ec7e13bd18667d9197603 200 Pfam PF00037 4Fe-4S binding domain 7 23 3.0E-5 T 09-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TK78_RS20835 75bb08f6280ec7e13bd18667d9197603 200 SUPERFAMILY SSF54862 1 153 3.77E-42 T 09-03-2017 TK78_RS20835 75bb08f6280ec7e13bd18667d9197603 200 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 88 99 - T 09-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TK78_RS20835 75bb08f6280ec7e13bd18667d9197603 200 Gene3D G3DSA:3.30.70.20 95 126 5.9E-13 T 09-03-2017 TK78_RS20835 75bb08f6280ec7e13bd18667d9197603 200 Gene3D G3DSA:3.30.70.20 127 150 1.6E-19 T 09-03-2017 TK78_RS20835 75bb08f6280ec7e13bd18667d9197603 200 Gene3D G3DSA:3.30.70.20 5 58 1.6E-19 T 09-03-2017 TK78_RS00305 92512562fa3166ca2989c879aae2d36c 561 Gene3D G3DSA:3.40.50.970 368 549 5.4E-60 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS00305 92512562fa3166ca2989c879aae2d36c 561 Gene3D G3DSA:3.40.50.970 14 185 2.1E-60 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS00305 92512562fa3166ca2989c879aae2d36c 561 Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain 14 173 3.8E-51 T 09-03-2017 IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain GO:0030976 TK78_RS00305 92512562fa3166ca2989c879aae2d36c 561 SUPERFAMILY SSF52467 194 378 4.24E-44 T 09-03-2017 IPR029035 DHS-like NAD/FAD-binding domain TK78_RS00305 92512562fa3166ca2989c879aae2d36c 561 SUPERFAMILY SSF52518 370 556 2.28E-56 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS00305 92512562fa3166ca2989c879aae2d36c 561 SUPERFAMILY SSF52518 14 182 4.86E-48 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS00305 92512562fa3166ca2989c879aae2d36c 561 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 394 540 3.8E-40 T 09-03-2017 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 TK78_RS00305 92512562fa3166ca2989c879aae2d36c 561 Gene3D G3DSA:3.40.50.1220 192 343 2.0E-46 T 09-03-2017 IPR029035 DHS-like NAD/FAD-binding domain TK78_RS00305 92512562fa3166ca2989c879aae2d36c 561 Pfam PF00205 Thiamine pyrophosphate enzyme, central domain 200 334 1.2E-35 T 09-03-2017 IPR012000 Thiamine pyrophosphate enzyme, central domain GO:0000287|GO:0030976 TK78_RS21815 0090bc6ae3e0301fc6318790db5ec0b7 398 SUPERFAMILY SSF51556 292 377 4.99E-100 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS21815 0090bc6ae3e0301fc6318790db5ec0b7 398 SUPERFAMILY SSF51556 4 252 4.99E-100 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS21815 0090bc6ae3e0301fc6318790db5ec0b7 398 Gene3D G3DSA:3.20.20.140 3 385 2.1E-145 T 09-03-2017 TK78_RS21815 0090bc6ae3e0301fc6318790db5ec0b7 398 Pfam PF01244 Membrane dipeptidase (Peptidase family M19) 12 369 4.3E-116 T 09-03-2017 IPR008257 Renal dipeptidase family GO:0006508|GO:0016805 MetaCyc: PWY-7533|Reactome: R-HSA-2142691|Reactome: R-HSA-5423646 TK78_RS01425 e2bc8fac89a79018b6c3e128a2705cba 223 SUPERFAMILY SSF48150 43 181 1.35E-8 T 09-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 TK78_RS01425 e2bc8fac89a79018b6c3e128a2705cba 223 Gene3D G3DSA:1.10.340.30 44 151 1.7E-6 T 09-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 TK78_RS13030 b7ef8ecbfeb60fc83e937a79eb3381f2 134 Gene3D G3DSA:3.30.420.80 11 134 1.8E-58 T 09-03-2017 IPR001971 Ribosomal protein S11 GO:0003735|GO:0005840|GO:0006412 TK78_RS13030 b7ef8ecbfeb60fc83e937a79eb3381f2 134 Pfam PF00411 Ribosomal protein S11 24 133 1.6E-48 T 09-03-2017 IPR001971 Ribosomal protein S11 GO:0003735|GO:0005840|GO:0006412 TK78_RS13030 b7ef8ecbfeb60fc83e937a79eb3381f2 134 ProSitePatterns PS00054 Ribosomal protein S11 signature. 102 124 - T 09-03-2017 IPR018102 Ribosomal S11, conserved site TK78_RS13030 b7ef8ecbfeb60fc83e937a79eb3381f2 134 PIRSF PIRSF002131 4 134 2.7E-54 T 09-03-2017 IPR001971 Ribosomal protein S11 GO:0003735|GO:0005840|GO:0006412 TK78_RS13030 b7ef8ecbfeb60fc83e937a79eb3381f2 134 SUPERFAMILY SSF53137 19 134 7.19E-50 T 09-03-2017 TK78_RS13030 b7ef8ecbfeb60fc83e937a79eb3381f2 134 Hamap MF_01310 30S ribosomal protein S11 [rpsK]. 6 134 34.437 T 09-03-2017 IPR001971 Ribosomal protein S11 GO:0003735|GO:0005840|GO:0006412 TK78_RS13030 b7ef8ecbfeb60fc83e937a79eb3381f2 134 TIGRFAM TIGR03632 uS11_bact: ribosomal protein uS11 15 131 1.7E-59 T 09-03-2017 IPR019981 Ribosomal protein S11, bacterial-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS06620 6aaa04a05e2bb94b4552a2a21233f4b5 499 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 136 145 9.6E-14 T 09-03-2017 TK78_RS06620 6aaa04a05e2bb94b4552a2a21233f4b5 499 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 18 40 9.6E-14 T 09-03-2017 TK78_RS06620 6aaa04a05e2bb94b4552a2a21233f4b5 499 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 332 339 9.6E-14 T 09-03-2017 TK78_RS06620 6aaa04a05e2bb94b4552a2a21233f4b5 499 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 177 202 9.6E-14 T 09-03-2017 TK78_RS06620 6aaa04a05e2bb94b4552a2a21233f4b5 499 PIRSF PIRSF037495 10 493 2.7E-140 T 09-03-2017 IPR017224 Opine oxidase, subunit A/hydrogen cyanide synthase, subunit B GO:0016491|GO:0055114 TK78_RS06620 6aaa04a05e2bb94b4552a2a21233f4b5 499 SUPERFAMILY SSF51905 17 384 4.15E-38 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS06620 6aaa04a05e2bb94b4552a2a21233f4b5 499 Gene3D G3DSA:3.50.50.60 140 358 2.6E-25 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS06620 6aaa04a05e2bb94b4552a2a21233f4b5 499 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 18 339 2.9E-19 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS06620 6aaa04a05e2bb94b4552a2a21233f4b5 499 Pfam PF04324 BFD-like [2Fe-2S] binding domain 409 457 3.9E-11 T 09-03-2017 IPR007419 BFD-like [2Fe-2S]-binding domain TK78_RS06620 6aaa04a05e2bb94b4552a2a21233f4b5 499 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 317 339 8.9E-19 T 09-03-2017 TK78_RS06620 6aaa04a05e2bb94b4552a2a21233f4b5 499 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 286 302 8.9E-19 T 09-03-2017 TK78_RS06620 6aaa04a05e2bb94b4552a2a21233f4b5 499 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 177 195 8.9E-19 T 09-03-2017 TK78_RS06620 6aaa04a05e2bb94b4552a2a21233f4b5 499 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 133 151 8.9E-19 T 09-03-2017 TK78_RS06620 6aaa04a05e2bb94b4552a2a21233f4b5 499 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 19 38 8.9E-19 T 09-03-2017 TK78_RS06620 6aaa04a05e2bb94b4552a2a21233f4b5 499 Gene3D G3DSA:3.50.50.60 13 139 4.6E-21 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS26265 08b1913db4f38e75d757bc4e8d65e3cb 141 SUPERFAMILY SSF54631 2 129 5.94E-32 T 09-03-2017 TK78_RS26265 08b1913db4f38e75d757bc4e8d65e3cb 141 Pfam PF00571 CBS domain 83 125 3.8E-9 T 09-03-2017 IPR000644 CBS domain TK78_RS26265 08b1913db4f38e75d757bc4e8d65e3cb 141 Pfam PF00571 CBS domain 4 57 3.3E-10 T 09-03-2017 IPR000644 CBS domain TK78_RS26265 08b1913db4f38e75d757bc4e8d65e3cb 141 Gene3D G3DSA:3.10.580.10 3 127 2.6E-31 T 09-03-2017 TK78_RS26265 08b1913db4f38e75d757bc4e8d65e3cb 141 SMART SM00116 79 126 8.6E-7 T 09-03-2017 IPR000644 CBS domain TK78_RS26265 08b1913db4f38e75d757bc4e8d65e3cb 141 SMART SM00116 11 61 1.5E-4 T 09-03-2017 IPR000644 CBS domain TK78_RS30185 7accde61bca304f25fa84a46cc5a48b6 420 SUPERFAMILY SSF55874 289 411 3.67E-18 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS30185 7accde61bca304f25fa84a46cc5a48b6 420 PIRSF PIRSF037434 26 417 6.2E-68 T 09-03-2017 IPR017205 Signal transduction histidine kinase, ChrS TK78_RS30185 7accde61bca304f25fa84a46cc5a48b6 420 SMART SM00387 320 413 4.6E-8 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS30185 7accde61bca304f25fa84a46cc5a48b6 420 PRINTS PR00344 Bacterial sensor protein C-terminal signature 357 371 2.1E-6 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS30185 7accde61bca304f25fa84a46cc5a48b6 420 PRINTS PR00344 Bacterial sensor protein C-terminal signature 373 391 2.1E-6 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS30185 7accde61bca304f25fa84a46cc5a48b6 420 PRINTS PR00344 Bacterial sensor protein C-terminal signature 397 410 2.1E-6 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS30185 7accde61bca304f25fa84a46cc5a48b6 420 Pfam PF07730 Histidine kinase 215 281 5.6E-14 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS30185 7accde61bca304f25fa84a46cc5a48b6 420 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 328 412 6.7E-5 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS30185 7accde61bca304f25fa84a46cc5a48b6 420 Gene3D G3DSA:3.30.565.10 319 413 4.6E-10 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS18730 38708b102279cc74ff1ef3694804ffa6 212 Gene3D G3DSA:3.40.50.1000 59 202 1.3E-43 T 09-03-2017 IPR023214 HAD-like domain TK78_RS18730 38708b102279cc74ff1ef3694804ffa6 212 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 78 175 4.8E-16 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS18730 38708b102279cc74ff1ef3694804ffa6 212 TIGRFAM TIGR01549 HAD-SF-IA-v1: HAD hydrolase, family IA, variant 1 82 170 5.9E-6 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS18730 38708b102279cc74ff1ef3694804ffa6 212 SUPERFAMILY SSF56784 2 202 2.66E-47 T 09-03-2017 IPR023214 HAD-like domain TK78_RS18730 38708b102279cc74ff1ef3694804ffa6 212 Pfam PF13419 Haloacid dehalogenase-like hydrolase 6 175 2.0E-20 T 09-03-2017 IPR023214 HAD-like domain TK78_RS03925 578d351cbfe188ef7e08c07051c54b9c 381 Pfam PF01658 Myo-inositol-1-phosphate synthase 215 319 6.1E-23 T 09-03-2017 IPR013021 Myo-inositol-1-phosphate synthase, GAPDH-like KEGG: 00521+5.5.1.4|KEGG: 00562+5.5.1.4|MetaCyc: PWY-2301|MetaCyc: PWY-4661|MetaCyc: PWY-6372|MetaCyc: PWY-6580|MetaCyc: PWY-6664|Reactome: R-HSA-1855183 TK78_RS03925 578d351cbfe188ef7e08c07051c54b9c 381 Gene3D G3DSA:3.30.360.10 216 314 4.4E-26 T 09-03-2017 TK78_RS03925 578d351cbfe188ef7e08c07051c54b9c 381 SUPERFAMILY SSF55347 214 318 1.24E-26 T 09-03-2017 TK78_RS03925 578d351cbfe188ef7e08c07051c54b9c 381 Pfam PF07994 Myo-inositol-1-phosphate synthase 122 370 2.5E-18 T 09-03-2017 IPR002587 Myo-inositol-1-phosphate synthase GO:0004512|GO:0006021|GO:0008654 KEGG: 00521+5.5.1.4|KEGG: 00562+5.5.1.4|MetaCyc: PWY-2301|MetaCyc: PWY-4661|MetaCyc: PWY-6372|MetaCyc: PWY-6580|MetaCyc: PWY-6664|Reactome: R-HSA-1855183 TK78_RS03925 578d351cbfe188ef7e08c07051c54b9c 381 SUPERFAMILY SSF51735 17 213 2.52E-55 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS03925 578d351cbfe188ef7e08c07051c54b9c 381 SUPERFAMILY SSF51735 318 375 2.52E-55 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS03925 578d351cbfe188ef7e08c07051c54b9c 381 PIRSF PIRSF015578 6 381 4.7E-83 T 09-03-2017 IPR002587 Myo-inositol-1-phosphate synthase GO:0004512|GO:0006021|GO:0008654 KEGG: 00521+5.5.1.4|KEGG: 00562+5.5.1.4|MetaCyc: PWY-2301|MetaCyc: PWY-4661|MetaCyc: PWY-6372|MetaCyc: PWY-6580|MetaCyc: PWY-6664|Reactome: R-HSA-1855183 TK78_RS03925 578d351cbfe188ef7e08c07051c54b9c 381 Gene3D G3DSA:3.40.50.720 318 377 6.4E-72 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS03925 578d351cbfe188ef7e08c07051c54b9c 381 Gene3D G3DSA:3.40.50.720 16 215 6.4E-72 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS24535 7b2e2238b9ed3824412abebfe2840f0a 478 TIGRFAM TIGR03595 Obg_CgtA_exten: Obg family GTPase CgtA, C-terminal extension 356 429 4.4E-28 T 09-03-2017 IPR015349 GTP-binding protein OBG, C-terminal GO:0000166 TK78_RS24535 7b2e2238b9ed3824412abebfe2840f0a 478 TIGRFAM TIGR02729 Obg_CgtA: Obg family GTPase CgtA 4 327 8.9E-124 T 09-03-2017 IPR014100 GTP-binding protein Obg/CgtA GO:0000287|GO:0003924|GO:0005525 TK78_RS24535 7b2e2238b9ed3824412abebfe2840f0a 478 SUPERFAMILY SSF52540 161 334 8.87E-48 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24535 7b2e2238b9ed3824412abebfe2840f0a 478 Pfam PF01018 GTP1/OBG 4 157 1.5E-51 T 09-03-2017 IPR006169 GTP1/OBG domain GO:0005525 TK78_RS24535 7b2e2238b9ed3824412abebfe2840f0a 478 ProSitePatterns PS00905 GTP1/OBG family signature. 212 225 - T 09-03-2017 IPR006074 GTP1/OBG, conserved site GO:0005525 TK78_RS24535 7b2e2238b9ed3824412abebfe2840f0a 478 Gene3D G3DSA:2.70.210.12 3 156 3.7E-48 T 09-03-2017 IPR006169 GTP1/OBG domain GO:0005525 TK78_RS24535 7b2e2238b9ed3824412abebfe2840f0a 478 SUPERFAMILY SSF82051 4 157 1.57E-46 T 09-03-2017 IPR006169 GTP1/OBG domain GO:0005525 TK78_RS24535 7b2e2238b9ed3824412abebfe2840f0a 478 Hamap MF_01454 GTPase Obg [obg]. 3 330 43.656 T 09-03-2017 IPR014100 GTP-binding protein Obg/CgtA GO:0000287|GO:0003924|GO:0005525 TK78_RS24535 7b2e2238b9ed3824412abebfe2840f0a 478 SUPERFAMILY SSF102741 354 430 7.32E-21 T 09-03-2017 IPR015349 GTP-binding protein OBG, C-terminal GO:0000166 TK78_RS24535 7b2e2238b9ed3824412abebfe2840f0a 478 Pfam PF01926 50S ribosome-binding GTPase 161 283 9.4E-23 T 09-03-2017 IPR006073 GTP binding domain GO:0005525 TK78_RS24535 7b2e2238b9ed3824412abebfe2840f0a 478 Pfam PF09269 Domain of unknown function (DUF1967) 356 428 4.3E-25 T 09-03-2017 IPR015349 GTP-binding protein OBG, C-terminal GO:0000166 TK78_RS24535 7b2e2238b9ed3824412abebfe2840f0a 478 Gene3D G3DSA:3.40.50.300 160 342 4.9E-48 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24535 7b2e2238b9ed3824412abebfe2840f0a 478 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 227 245 3.9E-35 T 09-03-2017 IPR006073 GTP binding domain GO:0005525 TK78_RS24535 7b2e2238b9ed3824412abebfe2840f0a 478 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 183 201 3.9E-35 T 09-03-2017 IPR006073 GTP binding domain GO:0005525 TK78_RS24535 7b2e2238b9ed3824412abebfe2840f0a 478 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 162 182 3.9E-35 T 09-03-2017 IPR006073 GTP binding domain GO:0005525 TK78_RS24535 7b2e2238b9ed3824412abebfe2840f0a 478 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 210 225 3.9E-35 T 09-03-2017 IPR006073 GTP binding domain GO:0005525 TK78_RS25345 ed9d497c95e6c536d6b4245707eab9e9 421 Gene3D G3DSA:1.20.1250.20 245 406 4.0E-13 T 09-03-2017 TK78_RS25345 ed9d497c95e6c536d6b4245707eab9e9 421 Gene3D G3DSA:1.20.1250.20 27 207 3.8E-21 T 09-03-2017 TK78_RS25345 ed9d497c95e6c536d6b4245707eab9e9 421 Pfam PF05977 Transmembrane secretion effector 17 411 3.3E-45 T 09-03-2017 IPR010290 Transmembrane secretion effector TK78_RS25345 ed9d497c95e6c536d6b4245707eab9e9 421 SUPERFAMILY SSF103473 27 414 4.32E-45 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS05455 cf0da4ea68885562a63857c0a38aa5fb 284 Pfam PF04545 Sigma-70, region 4 231 280 1.2E-16 T 09-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS05455 cf0da4ea68885562a63857c0a38aa5fb 284 SUPERFAMILY SSF88946 31 130 6.59E-27 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS05455 cf0da4ea68885562a63857c0a38aa5fb 284 TIGRFAM TIGR02980 SigBFG: RNA polymerase sigma-70 factor, sigma-B/F/G subfamily 55 281 5.5E-76 T 09-03-2017 IPR014322 RNA polymerase sigma-B/F/G type GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS05455 cf0da4ea68885562a63857c0a38aa5fb 284 Gene3D G3DSA:1.10.601.10 45 128 1.2E-21 T 09-03-2017 TK78_RS05455 cf0da4ea68885562a63857c0a38aa5fb 284 SUPERFAMILY SSF88659 134 201 5.23E-13 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS05455 cf0da4ea68885562a63857c0a38aa5fb 284 Pfam PF04539 Sigma-70 region 3 145 201 7.8E-7 T 09-03-2017 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS05455 cf0da4ea68885562a63857c0a38aa5fb 284 PRINTS PR00046 Major sigma-70 factor signature 235 247 2.6E-8 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS05455 cf0da4ea68885562a63857c0a38aa5fb 284 PRINTS PR00046 Major sigma-70 factor signature 252 267 2.6E-8 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS05455 cf0da4ea68885562a63857c0a38aa5fb 284 PRINTS PR00046 Major sigma-70 factor signature 85 98 2.6E-8 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS05455 cf0da4ea68885562a63857c0a38aa5fb 284 Pfam PF04542 Sigma-70 region 2 60 130 2.1E-14 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS05455 cf0da4ea68885562a63857c0a38aa5fb 284 Gene3D G3DSA:1.10.10.10 129 184 3.5E-16 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05455 cf0da4ea68885562a63857c0a38aa5fb 284 ProSitePatterns PS00715 Sigma-70 factors family signature 1. 85 98 - T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS05455 cf0da4ea68885562a63857c0a38aa5fb 284 SUPERFAMILY SSF88659 206 281 2.06E-15 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS05455 cf0da4ea68885562a63857c0a38aa5fb 284 Gene3D G3DSA:1.10.10.10 228 280 1.7E-8 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05455 cf0da4ea68885562a63857c0a38aa5fb 284 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 56 280 5.6E-30 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS28780 892ec7e711208191b1cb6d7bcf45e930 579 SUPERFAMILY SSF103473 16 207 2.22E-66 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS28780 892ec7e711208191b1cb6d7bcf45e930 579 SUPERFAMILY SSF103473 259 430 2.22E-66 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS28780 892ec7e711208191b1cb6d7bcf45e930 579 SUPERFAMILY SSF103473 484 510 2.22E-66 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS28780 892ec7e711208191b1cb6d7bcf45e930 579 Gene3D G3DSA:1.20.1250.20 277 431 3.3E-19 T 09-03-2017 TK78_RS28780 892ec7e711208191b1cb6d7bcf45e930 579 Gene3D G3DSA:1.20.1250.20 485 512 3.3E-19 T 09-03-2017 TK78_RS28780 892ec7e711208191b1cb6d7bcf45e930 579 Pfam PF07690 Major Facilitator Superfamily 27 420 9.5E-48 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS28780 892ec7e711208191b1cb6d7bcf45e930 579 Gene3D G3DSA:1.20.1250.20 24 208 2.5E-29 T 09-03-2017 TK78_RS28780 892ec7e711208191b1cb6d7bcf45e930 579 PRINTS PR01036 Tetracycline resistance protein TetB signature 26 50 5.2E-10 T 09-03-2017 TK78_RS28780 892ec7e711208191b1cb6d7bcf45e930 579 PRINTS PR01036 Tetracycline resistance protein TetB signature 213 231 5.2E-10 T 09-03-2017 TK78_RS28780 892ec7e711208191b1cb6d7bcf45e930 579 PRINTS PR01036 Tetracycline resistance protein TetB signature 411 430 5.2E-10 T 09-03-2017 TK78_RS28780 892ec7e711208191b1cb6d7bcf45e930 579 PRINTS PR01036 Tetracycline resistance protein TetB signature 148 172 5.2E-10 T 09-03-2017 TK78_RS28780 892ec7e711208191b1cb6d7bcf45e930 579 PRINTS PR01036 Tetracycline resistance protein TetB signature 86 108 5.2E-10 T 09-03-2017 TK78_RS30795 d07734228a03fc004427b40b1e284ab2 482 Gene3D G3DSA:3.30.1490.100 246 352 2.3E-30 T 09-03-2017 IPR017961 DNA polymerase, Y-family, little finger domain GO:0003684|GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7|Reactome: R-HSA-5656169 TK78_RS30795 d07734228a03fc004427b40b1e284ab2 482 Gene3D G3DSA:3.30.70.270 69 167 2.5E-23 T 09-03-2017 TK78_RS30795 d07734228a03fc004427b40b1e284ab2 482 Pfam PF00817 impB/mucB/samB family 10 158 1.7E-42 T 09-03-2017 IPR001126 UmuC domain GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7|Reactome: R-HSA-5656169 TK78_RS30795 d07734228a03fc004427b40b1e284ab2 482 SUPERFAMILY SSF100879 243 342 1.57E-25 T 09-03-2017 IPR017961 DNA polymerase, Y-family, little finger domain GO:0003684|GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7|Reactome: R-HSA-5656169 TK78_RS30795 d07734228a03fc004427b40b1e284ab2 482 SUPERFAMILY SSF56672 5 239 3.65E-68 T 09-03-2017 TK78_RS30795 d07734228a03fc004427b40b1e284ab2 482 Pfam PF11799 impB/mucB/samB family C-terminal domain 241 346 9.7E-20 T 09-03-2017 IPR017961 DNA polymerase, Y-family, little finger domain GO:0003684|GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7|Reactome: R-HSA-5656169 TK78_RS30795 d07734228a03fc004427b40b1e284ab2 482 Gene3D G3DSA:1.10.150.20 170 239 3.1E-19 T 09-03-2017 TK78_RS30795 d07734228a03fc004427b40b1e284ab2 482 Hamap MF_01113 DNA polymerase IV [dinB]. 4 352 33.958 T 09-03-2017 IPR022880 DNA polymerase IV GO:0003887 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7|Reactome: R-HSA-5655862|Reactome: R-HSA-5656169|Reactome: R-HSA-5685942|Reactome: R-HSA-5696397|Reactome: R-HSA-5696400|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210 TK78_RS33470 36f80c47818e353b6f2d5ca45542de1c 217 Pfam PF02469 Fasciclin domain 95 215 1.8E-32 T 09-03-2017 IPR000782 FAS1 domain TK78_RS33470 36f80c47818e353b6f2d5ca45542de1c 217 Gene3D G3DSA:2.30.180.10 86 214 2.0E-34 T 09-03-2017 IPR000782 FAS1 domain TK78_RS33470 36f80c47818e353b6f2d5ca45542de1c 217 SMART SM00554 119 216 1.4E-32 T 09-03-2017 IPR000782 FAS1 domain TK78_RS33470 36f80c47818e353b6f2d5ca45542de1c 217 SUPERFAMILY SSF82153 72 216 1.44E-37 T 09-03-2017 IPR000782 FAS1 domain TK78_RS28975 7d2dbf2d16a1eadc27a6df6f51da051f 439 TIGRFAM TIGR01015 hmgA: homogentisate 1,2-dioxygenase 14 437 1.7E-217 T 09-03-2017 IPR005708 Homogentisate 1,2-dioxygenase GO:0004411|GO:0006559|GO:0006570|GO:0055114 KEGG: 00350+1.13.11.5|KEGG: 00643+1.13.11.5|Reactome: R-HSA-71182 TK78_RS28975 7d2dbf2d16a1eadc27a6df6f51da051f 439 Gene3D G3DSA:2.60.120.10 253 407 8.4E-62 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS28975 7d2dbf2d16a1eadc27a6df6f51da051f 439 Gene3D G3DSA:2.60.120.10 204 237 7.2E-7 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS28975 7d2dbf2d16a1eadc27a6df6f51da051f 439 Hamap MF_00334 Homogentisate 1,2-dioxygenase [hmgA]. 15 439 72.317 T 09-03-2017 IPR022950 Homogentisate 1,2-dioxygenase, bacterial GO:0004411|GO:0006559|GO:0006572|GO:0055114 KEGG: 00350+1.13.11.5|KEGG: 00643+1.13.11.5 TK78_RS28975 7d2dbf2d16a1eadc27a6df6f51da051f 439 Pfam PF04209 homogentisate 1,2-dioxygenase 15 437 3.2E-211 T 09-03-2017 IPR005708 Homogentisate 1,2-dioxygenase GO:0004411|GO:0006559|GO:0006570|GO:0055114 KEGG: 00350+1.13.11.5|KEGG: 00643+1.13.11.5|Reactome: R-HSA-71182 TK78_RS28975 7d2dbf2d16a1eadc27a6df6f51da051f 439 SUPERFAMILY SSF51182 14 439 2.67E-162 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS04130 0450b5be9d0ec264a7a8cdd17957abc8 672 Gene3D G3DSA:3.40.50.1820 366 653 2.1E-64 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04130 0450b5be9d0ec264a7a8cdd17957abc8 672 SUPERFAMILY SSF53474 401 653 1.09E-57 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04130 0450b5be9d0ec264a7a8cdd17957abc8 672 Gene3D G3DSA:2.130.10.10 324 365 1.4E-6 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS04130 0450b5be9d0ec264a7a8cdd17957abc8 672 Gene3D G3DSA:2.130.10.10 178 267 1.4E-6 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS04130 0450b5be9d0ec264a7a8cdd17957abc8 672 SUPERFAMILY SSF82171 164 388 2.12E-15 T 09-03-2017 TK78_RS04130 0450b5be9d0ec264a7a8cdd17957abc8 672 SUPERFAMILY SSF82171 76 135 2.12E-15 T 09-03-2017 TK78_RS04130 0450b5be9d0ec264a7a8cdd17957abc8 672 Pfam PF00326 Prolyl oligopeptidase family 454 656 1.4E-42 T 09-03-2017 IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain GO:0006508|GO:0008236 TK78_RS15465 134465f24acbf30a2b6c396406df38d4 750 Gene3D G3DSA:3.40.710.10 264 696 2.5E-106 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS15465 134465f24acbf30a2b6c396406df38d4 750 Gene3D G3DSA:1.10.3810.10 77 263 7.1E-72 T 09-03-2017 TK78_RS15465 134465f24acbf30a2b6c396406df38d4 750 Pfam PF00905 Penicillin binding protein transpeptidase domain 362 632 3.5E-36 T 09-03-2017 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 TK78_RS15465 134465f24acbf30a2b6c396406df38d4 750 SUPERFAMILY SSF53955 63 286 3.94E-70 T 09-03-2017 IPR023346 Lysozyme-like domain TK78_RS15465 134465f24acbf30a2b6c396406df38d4 750 Pfam PF00912 Transglycosylase 77 261 1.4E-63 T 09-03-2017 IPR001264 Glycosyl transferase, family 51 TK78_RS15465 134465f24acbf30a2b6c396406df38d4 750 SUPERFAMILY SSF56601 243 265 9.52E-92 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS15465 134465f24acbf30a2b6c396406df38d4 750 SUPERFAMILY SSF56601 299 679 9.52E-92 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS16890 a68d50443993c194e0c7b2435a13d23c 57 Pfam PF12728 Helix-turn-helix domain 1 51 3.9E-9 T 09-03-2017 TK78_RS31750 211579a8e862f0076bf1c2302af6d1f7 343 Pfam PF01636 Phosphotransferase enzyme family 82 279 7.9E-9 T 09-03-2017 IPR002575 Aminoglycoside phosphotransferase TK78_RS31750 211579a8e862f0076bf1c2302af6d1f7 343 SUPERFAMILY SSF56112 39 314 9.39E-14 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS31750 211579a8e862f0076bf1c2302af6d1f7 343 Gene3D G3DSA:3.90.1200.10 122 298 1.7E-5 T 09-03-2017 TK78_RS33835 0d1ac46a645a99d4464fe8c242b8924b 545 TIGRFAM TIGR02275 DHB_AMP_lig: (2,3-dihydroxybenzoyl)adenylate synthase 8 532 4.0E-231 T 09-03-2017 IPR011963 2,3-dihydroxybenzoate-AMP ligase GO:0008668|GO:0019290 TK78_RS33835 0d1ac46a645a99d4464fe8c242b8924b 545 Gene3D G3DSA:2.30.38.10 358 433 1.0E-22 T 09-03-2017 TK78_RS33835 0d1ac46a645a99d4464fe8c242b8924b 545 SUPERFAMILY SSF56801 9 535 6.54E-137 T 09-03-2017 TK78_RS33835 0d1ac46a645a99d4464fe8c242b8924b 545 Gene3D G3DSA:3.40.50.980 195 346 4.5E-36 T 09-03-2017 TK78_RS33835 0d1ac46a645a99d4464fe8c242b8924b 545 Pfam PF13193 AMP-binding enzyme C-terminal domain 448 525 9.6E-17 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS33835 0d1ac46a645a99d4464fe8c242b8924b 545 Pfam PF00501 AMP-binding enzyme 33 439 2.4E-83 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS33835 0d1ac46a645a99d4464fe8c242b8924b 545 Gene3D G3DSA:3.30.300.30 434 537 8.3E-29 T 09-03-2017 TK78_RS33835 0d1ac46a645a99d4464fe8c242b8924b 545 Gene3D G3DSA:3.40.50.980 27 194 8.2E-29 T 09-03-2017 TK78_RS33835 0d1ac46a645a99d4464fe8c242b8924b 545 ProSitePatterns PS00455 Putative AMP-binding domain signature. 191 202 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS28005 08481a8521953e728b9cde7c44ec9eaa 151 SUPERFAMILY SSF82649 2 141 1.2E-43 T 09-03-2017 TK78_RS28005 08481a8521953e728b9cde7c44ec9eaa 151 Gene3D G3DSA:3.90.1010.10 5 147 5.1E-45 T 09-03-2017 TK78_RS28005 08481a8521953e728b9cde7c44ec9eaa 151 Pfam PF01592 NifU-like N terminal domain 6 129 9.8E-27 T 09-03-2017 IPR002871 NIF system FeS cluster assembly, NifU, N-terminal GO:0005506|GO:0016226|GO:0051536 Reactome: R-HSA-1362409 TK78_RS28005 08481a8521953e728b9cde7c44ec9eaa 151 TIGRFAM TIGR01994 SUF_scaf_2: SUF system FeS assembly protein, NifU family 3 140 5.8E-48 T 09-03-2017 TK78_RS23335 d3547f14246ed1359dd54996d57257c4 268 PIRSF PIRSF038992 1 261 3.9E-68 T 09-03-2017 IPR002915 DeoC/FbaB/ lacD aldolase GO:0016829 Reactome: R-HSA-71336 TK78_RS23335 d3547f14246ed1359dd54996d57257c4 268 Pfam PF01791 DeoC/LacD family aldolase 24 234 2.8E-38 T 09-03-2017 IPR002915 DeoC/FbaB/ lacD aldolase GO:0016829 Reactome: R-HSA-71336 TK78_RS23335 d3547f14246ed1359dd54996d57257c4 268 SUPERFAMILY SSF51569 5 251 1.98E-59 T 09-03-2017 TK78_RS23335 d3547f14246ed1359dd54996d57257c4 268 SMART SM01133 21 235 9.3E-34 T 09-03-2017 IPR002915 DeoC/FbaB/ lacD aldolase GO:0016829 Reactome: R-HSA-71336 TK78_RS23335 d3547f14246ed1359dd54996d57257c4 268 Gene3D G3DSA:3.20.20.70 5 253 6.5E-67 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS07755 7ff44fb6e035bcdf412e0d065e891bc5 363 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 155 362 8.3E-36 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS07755 7ff44fb6e035bcdf412e0d065e891bc5 363 Gene3D G3DSA:1.10.3720.10 131 355 8.8E-12 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS07755 7ff44fb6e035bcdf412e0d065e891bc5 363 SUPERFAMILY SSF161098 133 351 6.28E-14 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS28950 8ee28ee04afdb16552d4a7ccd339fcdd 267 Gene3D G3DSA:3.40.50.1110 33 256 9.8E-69 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS28950 8ee28ee04afdb16552d4a7ccd339fcdd 267 SUPERFAMILY SSF52266 36 255 9.66E-65 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS28950 8ee28ee04afdb16552d4a7ccd339fcdd 267 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 40 255 1.2E-24 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS15945 8c17f2caff06f4eabb4ed2167868133f 222 SUPERFAMILY SSF52172 5 137 7.83E-36 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS15945 8c17f2caff06f4eabb4ed2167868133f 222 ProSitePatterns PS00622 LuxR-type HTH domain signature. 173 200 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS15945 8c17f2caff06f4eabb4ed2167868133f 222 SMART SM00448 6 119 3.5E-33 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS15945 8c17f2caff06f4eabb4ed2167868133f 222 Gene3D G3DSA:1.10.10.10 129 220 3.5E-31 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS15945 8c17f2caff06f4eabb4ed2167868133f 222 SUPERFAMILY SSF46894 145 219 5.78E-22 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS15945 8c17f2caff06f4eabb4ed2167868133f 222 Gene3D G3DSA:3.40.50.2300 2 128 5.6E-41 T 09-03-2017 TK78_RS15945 8c17f2caff06f4eabb4ed2167868133f 222 Pfam PF00196 Bacterial regulatory proteins, luxR family 159 213 8.1E-18 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS15945 8c17f2caff06f4eabb4ed2167868133f 222 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 173 189 4.1E-14 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS15945 8c17f2caff06f4eabb4ed2167868133f 222 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 159 173 4.1E-14 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS15945 8c17f2caff06f4eabb4ed2167868133f 222 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 189 201 4.1E-14 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS15945 8c17f2caff06f4eabb4ed2167868133f 222 Pfam PF00072 Response regulator receiver domain 8 117 6.3E-28 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS15945 8c17f2caff06f4eabb4ed2167868133f 222 SMART SM00421 156 213 5.4E-24 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS09480 f88d01e7cec7cc4eb7a0fac98ea7eab3 185 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 9 157 4.1E-18 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS09480 f88d01e7cec7cc4eb7a0fac98ea7eab3 185 SUPERFAMILY SSF88659 90 159 7.66E-16 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS09480 f88d01e7cec7cc4eb7a0fac98ea7eab3 185 Pfam PF08281 Sigma-70, region 4 104 155 5.3E-16 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS09480 f88d01e7cec7cc4eb7a0fac98ea7eab3 185 TIGRFAM TIGR02983 SigE-fam_strep: RNA polymerase sigma-70 factor, sigma-E family 4 161 3.6E-55 T 09-03-2017 IPR014325 RNA polymerase sigma-E factor, actinobacteria GO:0016987 TK78_RS09480 f88d01e7cec7cc4eb7a0fac98ea7eab3 185 Gene3D G3DSA:1.10.10.10 99 158 1.4E-18 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS09480 f88d01e7cec7cc4eb7a0fac98ea7eab3 185 Gene3D G3DSA:1.10.1740.10 6 79 6.9E-9 T 09-03-2017 TK78_RS09480 f88d01e7cec7cc4eb7a0fac98ea7eab3 185 SUPERFAMILY SSF88946 4 73 8.24E-8 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS28840 fa94d5477b1600706212d667b1122ab7 273 Pfam PF07920 Protein of unknown function (DUF1684) 134 268 3.3E-34 T 09-03-2017 IPR012467 Protein of unknown function DUF1684 TK78_RS28840 fa94d5477b1600706212d667b1122ab7 273 SUPERFAMILY SSF50960 45 206 8.89E-5 T 09-03-2017 TK78_RS00750 7a2e963a1e3ee174e28c5d2110e1598c 780 SUPERFAMILY SSF51445 19 323 9.16E-82 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS00750 7a2e963a1e3ee174e28c5d2110e1598c 780 Pfam PF01915 Glycosyl hydrolase family 3 C-terminal domain 325 571 2.5E-52 T 09-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 TK78_RS00750 7a2e963a1e3ee174e28c5d2110e1598c 780 Pfam PF14310 Fibronectin type III-like domain 606 677 6.1E-21 T 09-03-2017 IPR026891 Fibronectin type III-like domain TK78_RS00750 7a2e963a1e3ee174e28c5d2110e1598c 780 Gene3D G3DSA:3.20.20.300 20 305 1.2E-91 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS00750 7a2e963a1e3ee174e28c5d2110e1598c 780 ProSitePatterns PS00775 Glycosyl hydrolases family 3 active site. 226 243 - T 09-03-2017 IPR019800 Glycoside hydrolase, family 3, active site GO:0004553|GO:0005975 TK78_RS00750 7a2e963a1e3ee174e28c5d2110e1598c 780 Gene3D G3DSA:3.40.50.1700 311 574 2.1E-66 T 09-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 TK78_RS00750 7a2e963a1e3ee174e28c5d2110e1598c 780 Pfam PF00933 Glycosyl hydrolase family 3 N terminal domain 66 293 3.7E-49 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS00750 7a2e963a1e3ee174e28c5d2110e1598c 780 SUPERFAMILY SSF52279 325 574 7.06E-53 T 09-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 TK78_RS00750 7a2e963a1e3ee174e28c5d2110e1598c 780 SMART SM01217 606 677 1.1E-26 T 09-03-2017 IPR026891 Fibronectin type III-like domain TK78_RS00750 7a2e963a1e3ee174e28c5d2110e1598c 780 PRINTS PR00133 Glycosyl hydrolase family 3 signature 41 57 1.4E-23 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS00750 7a2e963a1e3ee174e28c5d2110e1598c 780 PRINTS PR00133 Glycosyl hydrolase family 3 signature 226 244 1.4E-23 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS00750 7a2e963a1e3ee174e28c5d2110e1598c 780 PRINTS PR00133 Glycosyl hydrolase family 3 signature 156 172 1.4E-23 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS00750 7a2e963a1e3ee174e28c5d2110e1598c 780 PRINTS PR00133 Glycosyl hydrolase family 3 signature 125 141 1.4E-23 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS17745 247d5254b60b2450cdbf6d09e640df22 111 SMART SM00418 13 91 1.1E-25 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS17745 247d5254b60b2450cdbf6d09e640df22 111 SUPERFAMILY SSF46785 10 95 3.67E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS17745 247d5254b60b2450cdbf6d09e640df22 111 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 47 62 1.2E-8 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS17745 247d5254b60b2450cdbf6d09e640df22 111 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 62 77 1.2E-8 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS17745 247d5254b60b2450cdbf6d09e640df22 111 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 15 30 1.2E-8 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS17745 247d5254b60b2450cdbf6d09e640df22 111 Gene3D G3DSA:1.10.10.10 5 98 2.3E-24 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS17745 247d5254b60b2450cdbf6d09e640df22 111 Pfam PF01022 Bacterial regulatory protein, arsR family 20 64 4.7E-15 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS34085 e5a7744ab229bfa8d2ec6f2467fc4652 501 Gene3D G3DSA:3.40.50.980 174 318 2.6E-33 T 09-03-2017 TK78_RS34085 e5a7744ab229bfa8d2ec6f2467fc4652 501 Gene3D G3DSA:3.40.50.980 8 173 7.2E-39 T 09-03-2017 TK78_RS34085 e5a7744ab229bfa8d2ec6f2467fc4652 501 Gene3D G3DSA:3.30.300.30 401 498 2.1E-30 T 09-03-2017 TK78_RS34085 e5a7744ab229bfa8d2ec6f2467fc4652 501 Gene3D G3DSA:2.30.38.10 325 399 8.7E-27 T 09-03-2017 TK78_RS34085 e5a7744ab229bfa8d2ec6f2467fc4652 501 SUPERFAMILY SSF56801 6 499 1.44E-146 T 09-03-2017 TK78_RS34085 e5a7744ab229bfa8d2ec6f2467fc4652 501 Pfam PF00501 AMP-binding enzyme 14 406 5.0E-97 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS34085 e5a7744ab229bfa8d2ec6f2467fc4652 501 Pfam PF13193 AMP-binding enzyme C-terminal domain 416 490 3.5E-23 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS33420 bd04bc9c5519e8a61800c29e63f8d1ce 566 Pfam PF00005 ABC transporter 387 510 3.1E-19 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS33420 bd04bc9c5519e8a61800c29e63f8d1ce 566 Pfam PF00005 ABC transporter 25 200 1.3E-28 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS33420 bd04bc9c5519e8a61800c29e63f8d1ce 566 SUPERFAMILY SSF52540 11 241 1.87E-48 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33420 bd04bc9c5519e8a61800c29e63f8d1ce 566 SMART SM00382 34 245 2.8E-16 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS33420 bd04bc9c5519e8a61800c29e63f8d1ce 566 SMART SM00382 391 554 1.1E-11 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS33420 bd04bc9c5519e8a61800c29e63f8d1ce 566 ProSitePatterns PS00211 ABC transporters family signature. 172 186 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS33420 bd04bc9c5519e8a61800c29e63f8d1ce 566 Gene3D G3DSA:3.40.50.300 387 559 8.2E-34 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33420 bd04bc9c5519e8a61800c29e63f8d1ce 566 ProSitePatterns PS00211 ABC transporters family signature. 482 496 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS33420 bd04bc9c5519e8a61800c29e63f8d1ce 566 SUPERFAMILY SSF52540 388 557 1.48E-35 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33420 bd04bc9c5519e8a61800c29e63f8d1ce 566 Gene3D G3DSA:3.40.50.300 9 109 2.1E-50 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33420 bd04bc9c5519e8a61800c29e63f8d1ce 566 Gene3D G3DSA:3.40.50.300 146 242 2.1E-50 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03195 c8167618063337ac6c015e6d460a9936 584 ProSitePatterns PS00379 CDP-alcohol phosphatidyltransferases signature. 224 246 - T 09-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 TK78_RS03195 c8167618063337ac6c015e6d460a9936 584 Pfam PF01066 CDP-alcohol phosphatidyltransferase 180 246 1.7E-8 T 09-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 TK78_RS15900 a8ded31c265b542ff940b8a5702e8286 214 Gene3D G3DSA:1.10.1740.10 2 112 1.2E-30 T 09-03-2017 TK78_RS15900 a8ded31c265b542ff940b8a5702e8286 214 SUPERFAMILY SSF88946 2 97 5.23E-24 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS15900 a8ded31c265b542ff940b8a5702e8286 214 Pfam PF04542 Sigma-70 region 2 21 88 9.9E-16 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS15900 a8ded31c265b542ff940b8a5702e8286 214 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 16 174 1.8E-23 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS15900 a8ded31c265b542ff940b8a5702e8286 214 Gene3D G3DSA:1.10.10.10 114 178 5.4E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS15900 a8ded31c265b542ff940b8a5702e8286 214 SUPERFAMILY SSF88659 114 176 2.07E-15 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS15900 a8ded31c265b542ff940b8a5702e8286 214 Pfam PF08281 Sigma-70, region 4 121 173 1.0E-14 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16970 ace3883d41e66884e89ef1de592d247e 249 Pfam PF07987 Domain of unkown function (DUF1775) 27 175 1.2E-50 T 09-03-2017 IPR012533 GLE1, N-terminal, bacteria TK78_RS25210 dbaebcf145d3dd11e5b405ec2cbe09d0 202 SUPERFAMILY SSF52218 15 187 5.53E-40 T 09-03-2017 IPR029039 Flavoprotein-like domain TK78_RS25210 dbaebcf145d3dd11e5b405ec2cbe09d0 202 Gene3D G3DSA:3.40.50.360 8 197 5.4E-47 T 09-03-2017 IPR029039 Flavoprotein-like domain TK78_RS25210 dbaebcf145d3dd11e5b405ec2cbe09d0 202 Pfam PF03358 NADPH-dependent FMN reductase 15 157 3.0E-38 T 09-03-2017 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 TK78_RS23685 d0307550fa20f7aba154fc7827301c7c 1262 Pfam PF00664 ABC transporter transmembrane region 695 965 2.4E-40 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS23685 d0307550fa20f7aba154fc7827301c7c 1262 Pfam PF00664 ABC transporter transmembrane region 26 293 4.1E-34 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS23685 d0307550fa20f7aba154fc7827301c7c 1262 SUPERFAMILY SSF90123 683 998 5.76E-73 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS23685 d0307550fa20f7aba154fc7827301c7c 1262 SMART SM00382 1036 1222 3.0E-19 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS23685 d0307550fa20f7aba154fc7827301c7c 1262 SMART SM00382 379 564 1.6E-13 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS23685 d0307550fa20f7aba154fc7827301c7c 1262 Gene3D G3DSA:3.40.50.300 338 580 9.6E-77 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23685 d0307550fa20f7aba154fc7827301c7c 1262 Gene3D G3DSA:3.40.50.300 1011 1241 5.6E-76 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23685 d0307550fa20f7aba154fc7827301c7c 1262 Gene3D G3DSA:1.20.1560.10 11 321 4.6E-66 T 09-03-2017 TK78_RS23685 d0307550fa20f7aba154fc7827301c7c 1262 Gene3D G3DSA:1.20.1560.10 683 999 7.4E-78 T 09-03-2017 TK78_RS23685 d0307550fa20f7aba154fc7827301c7c 1262 SUPERFAMILY SSF90123 11 325 1.7E-69 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS23685 d0307550fa20f7aba154fc7827301c7c 1262 Pfam PF00005 ABC transporter 1028 1176 3.7E-30 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS23685 d0307550fa20f7aba154fc7827301c7c 1262 Pfam PF00005 ABC transporter 370 519 6.9E-30 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS23685 d0307550fa20f7aba154fc7827301c7c 1262 ProSitePatterns PS00211 ABC transporters family signature. 491 505 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS23685 d0307550fa20f7aba154fc7827301c7c 1262 SUPERFAMILY SSF52540 335 586 4.44E-83 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23685 d0307550fa20f7aba154fc7827301c7c 1262 SUPERFAMILY SSF52540 1001 1245 3.2E-83 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29775 85ca988faf1e3cbba0e6965b0df2fcb4 75 Pfam PF03621 MbtH-like protein 1 53 1.2E-29 T 09-03-2017 IPR005153 MbtH-like protein TK78_RS29775 85ca988faf1e3cbba0e6965b0df2fcb4 75 SUPERFAMILY SSF160582 1 69 3.14E-31 T 09-03-2017 TK78_RS29775 85ca988faf1e3cbba0e6965b0df2fcb4 75 Gene3D G3DSA:3.90.820.10 10 69 4.0E-32 T 09-03-2017 TK78_RS29775 85ca988faf1e3cbba0e6965b0df2fcb4 75 SMART SM00923 3 53 1.7E-33 T 09-03-2017 IPR005153 MbtH-like protein TK78_RS14050 d746d429b6dc9c02eb2f26c58d89c106 228 Pfam PF09250 Bifunctional DNA primase/polymerase, N-terminal 28 199 2.4E-21 T 09-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal TK78_RS14050 d746d429b6dc9c02eb2f26c58d89c106 228 SMART SM00943 28 212 1.3E-32 T 09-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal TK78_RS08035 270f9e69a4c41cf9e98ae65d88ddad31 418 SUPERFAMILY SSF55874 321 418 1.72E-13 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS08035 270f9e69a4c41cf9e98ae65d88ddad31 418 Gene3D G3DSA:3.30.565.10 332 417 1.5E-4 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS08035 270f9e69a4c41cf9e98ae65d88ddad31 418 Pfam PF07730 Histidine kinase 215 280 5.9E-17 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS32080 fa61e7a14ad17e450a425600ea1bd476 565 SUPERFAMILY SSF53067 290 540 1.21E-55 T 09-03-2017 TK78_RS32080 fa61e7a14ad17e450a425600ea1bd476 565 Gene3D G3DSA:3.30.420.40 14 285 4.7E-40 T 09-03-2017 TK78_RS32080 fa61e7a14ad17e450a425600ea1bd476 565 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 299 495 2.4E-41 T 09-03-2017 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 TK78_RS32080 fa61e7a14ad17e450a425600ea1bd476 565 TIGRFAM TIGR01234 L-ribulokinase: ribulokinase 14 542 1.4E-223 T 09-03-2017 IPR005929 Ribulokinase GO:0005524|GO:0008741|GO:0019569 KEGG: 00040+2.7.1.16 TK78_RS32080 fa61e7a14ad17e450a425600ea1bd476 565 PIRSF PIRSF000538 12 540 5.7E-64 T 09-03-2017 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 TK78_RS32080 fa61e7a14ad17e450a425600ea1bd476 565 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 15 285 7.9E-11 T 09-03-2017 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 TK78_RS32080 fa61e7a14ad17e450a425600ea1bd476 565 SUPERFAMILY SSF53067 15 290 1.35E-36 T 09-03-2017 TK78_RS32080 fa61e7a14ad17e450a425600ea1bd476 565 Gene3D G3DSA:3.30.420.40 290 538 4.7E-53 T 09-03-2017 TK78_RS32080 fa61e7a14ad17e450a425600ea1bd476 565 ProSitePatterns PS00445 FGGY family of carbohydrate kinases signature 2. 407 427 - T 09-03-2017 IPR018483 Carbohydrate kinase, FGGY, conserved site GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 TK78_RS15185 3ca9a2f35c15a9789d287e5f690e5e79 463 Gene3D G3DSA:3.50.50.60 293 350 1.0E-4 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS15185 3ca9a2f35c15a9789d287e5f690e5e79 463 Gene3D G3DSA:3.50.50.60 208 243 1.0E-4 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS15185 3ca9a2f35c15a9789d287e5f690e5e79 463 SUPERFAMILY SSF51905 6 281 4.88E-15 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS15185 3ca9a2f35c15a9789d287e5f690e5e79 463 Pfam PF13434 L-lysine 6-monooxygenase (NADPH-requiring) 9 352 2.7E-111 T 09-03-2017 IPR025700 L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase TK78_RS15185 3ca9a2f35c15a9789d287e5f690e5e79 463 Gene3D G3DSA:3.50.50.60 96 207 1.1E-9 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS08360 3029f534acf85747a3397d50020cc105 197 SUPERFAMILY SSF52016 1 187 7.85E-53 T 09-03-2017 IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel TK78_RS08360 3029f534acf85747a3397d50020cc105 197 Gene3D G3DSA:3.20.19.10 1 187 6.5E-42 T 09-03-2017 IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel TK78_RS08360 3029f534acf85747a3397d50020cc105 197 Hamap MF_01031 3-isopropylmalate dehydratase small subunit [leuD]. 1 191 40.228 T 09-03-2017 IPR004431 3-isopropylmalate dehydratase, small subunit GO:0003861|GO:0009098|GO:0009316 KEGG: 00290+4.2.1.33 TK78_RS08360 3029f534acf85747a3397d50020cc105 197 Pfam PF00694 Aconitase C-terminal domain 1 117 1.3E-24 T 09-03-2017 IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel domain GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS08360 3029f534acf85747a3397d50020cc105 197 TIGRFAM TIGR00171 leuD: 3-isopropylmalate dehydratase, small subunit 1 180 4.7E-57 T 09-03-2017 IPR004431 3-isopropylmalate dehydratase, small subunit GO:0003861|GO:0009098|GO:0009316 KEGG: 00290+4.2.1.33 TK78_RS05960 5913da19bd0f337089e29cfc8d42a092 559 Pfam PF11380 Stealth protein CR2, conserved region 2 271 377 8.5E-48 T 09-03-2017 IPR021520 Stealth protein CR2, conserved region 2 GO:0016772 TK78_RS05960 5913da19bd0f337089e29cfc8d42a092 559 Pfam PF17103 Stealth protein CR4, conserved region 4 496 547 3.5E-16 T 09-03-2017 IPR031356 Stealth protein CR4, conserved region 4 TK78_RS05960 5913da19bd0f337089e29cfc8d42a092 559 Pfam PF17101 Stealth protein CR1, conserved region 1 227 254 3.1E-10 T 09-03-2017 IPR031358 Stealth protein CR1, conserved region 1 TK78_RS05960 5913da19bd0f337089e29cfc8d42a092 559 Pfam PF17102 Stealth protein CR3, conserved region 3 421 469 2.8E-14 T 09-03-2017 IPR031357 Stealth protein CR3, conserved region 3 TK78_RS04835 1bcd9e0a2e67ec87a650721f0a520320 339 Gene3D G3DSA:3.30.360.10 136 333 1.9E-48 T 09-03-2017 TK78_RS04835 1bcd9e0a2e67ec87a650721f0a520320 339 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 1 122 1.6E-14 T 09-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 TK78_RS04835 1bcd9e0a2e67ec87a650721f0a520320 339 Gene3D G3DSA:3.40.50.720 1 135 7.3E-29 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS04835 1bcd9e0a2e67ec87a650721f0a520320 339 SUPERFAMILY SSF55347 133 269 2.13E-24 T 09-03-2017 TK78_RS04835 1bcd9e0a2e67ec87a650721f0a520320 339 SUPERFAMILY SSF51735 2 152 9.78E-34 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS04835 1bcd9e0a2e67ec87a650721f0a520320 339 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 136 241 9.5E-8 T 09-03-2017 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 TK78_RS26580 657b0117e7cebdbb22fa10c94eb3e46d 275 ProDom PD006086 LIGASE LIPOATE-PROTEIN B TRANSFERASE ACYLTRANSFERASE LIPOYLTRANSFERASE LIPOYL-ACYL-CARRIER 2.3.1.- PROTEIN-PROTEIN- N-LIPOYLTRANSFERASE 77 129 5.0E-22 T 09-03-2017 TK78_RS26580 657b0117e7cebdbb22fa10c94eb3e46d 275 Hamap MF_00013 Octanoyltransferase [lipB]. 3 253 32.948 T 09-03-2017 IPR000544 Octanoyltransferase GO:0005737|GO:0009107|GO:0016415 KEGG: 00785+2.3.1.181|MetaCyc: PWY-6987|MetaCyc: PWY-7382|Reactome: R-HSA-389661 TK78_RS26580 657b0117e7cebdbb22fa10c94eb3e46d 275 Gene3D G3DSA:3.90.1550.10 179 250 5.1E-76 T 09-03-2017 TK78_RS26580 657b0117e7cebdbb22fa10c94eb3e46d 275 Gene3D G3DSA:3.90.1550.10 13 136 5.1E-76 T 09-03-2017 TK78_RS26580 657b0117e7cebdbb22fa10c94eb3e46d 275 SUPERFAMILY SSF55681 15 132 9.11E-60 T 09-03-2017 TK78_RS26580 657b0117e7cebdbb22fa10c94eb3e46d 275 SUPERFAMILY SSF55681 178 251 9.11E-60 T 09-03-2017 TK78_RS26580 657b0117e7cebdbb22fa10c94eb3e46d 275 PIRSF PIRSF016262 4 261 1.9E-58 T 09-03-2017 IPR000544 Octanoyltransferase GO:0005737|GO:0009107|GO:0016415 KEGG: 00785+2.3.1.181|MetaCyc: PWY-6987|MetaCyc: PWY-7382|Reactome: R-HSA-389661 TK78_RS26580 657b0117e7cebdbb22fa10c94eb3e46d 275 ProSitePatterns PS01313 Lipoate-protein ligase B signature. 73 88 - T 09-03-2017 IPR020605 Octanoyltransferase, conserved site GO:0005737|GO:0009107|GO:0016415 KEGG: 00785+2.3.1.181|MetaCyc: PWY-6987|MetaCyc: PWY-7382 TK78_RS28630 67eaa5e1bab41c32c07b984750d83ca4 551 Gene3D G3DSA:3.40.50.300 4 290 1.2E-131 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28630 67eaa5e1bab41c32c07b984750d83ca4 551 Hamap MF_01227 CTP synthase [pyrG]. 8 546 50.278 T 09-03-2017 IPR004468 CTP synthase GO:0003883|GO:0006221 KEGG: 00240+6.3.4.2|MetaCyc: PWY-7176|MetaCyc: PWY-7177|MetaCyc: PWY-7185|Reactome: R-HSA-499943 TK78_RS28630 67eaa5e1bab41c32c07b984750d83ca4 551 Pfam PF06418 CTP synthase N-terminus 9 272 8.2E-123 T 09-03-2017 IPR017456 CTP synthase, N-terminal GO:0003883|GO:0006221 KEGG: 00240+6.3.4.2|MetaCyc: PWY-7176|MetaCyc: PWY-7177|MetaCyc: PWY-7185|Reactome: R-HSA-499943 TK78_RS28630 67eaa5e1bab41c32c07b984750d83ca4 551 Gene3D G3DSA:3.40.50.880 294 546 1.9E-83 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS28630 67eaa5e1bab41c32c07b984750d83ca4 551 SUPERFAMILY SSF52540 8 272 4.32E-118 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28630 67eaa5e1bab41c32c07b984750d83ca4 551 SUPERFAMILY SSF52317 294 546 5.85E-69 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS28630 67eaa5e1bab41c32c07b984750d83ca4 551 TIGRFAM TIGR00337 PyrG: CTP synthase 7 541 4.2E-228 T 09-03-2017 IPR004468 CTP synthase GO:0003883|GO:0006221 KEGG: 00240+6.3.4.2|MetaCyc: PWY-7176|MetaCyc: PWY-7177|MetaCyc: PWY-7185|Reactome: R-HSA-499943 TK78_RS28630 67eaa5e1bab41c32c07b984750d83ca4 551 Pfam PF00117 Glutamine amidotransferase class-I 307 541 1.1E-46 T 09-03-2017 IPR017926 Glutamine amidotransferase TK78_RS24820 0e5a5d38f048a7e05dc0bb9f7914ba0e 432 Pfam PF03471 Transporter associated domain 338 421 8.9E-13 T 09-03-2017 IPR005170 Transporter-associated domain TK78_RS24820 0e5a5d38f048a7e05dc0bb9f7914ba0e 432 Pfam PF00571 CBS domain 276 322 1.6E-6 T 09-03-2017 IPR000644 CBS domain TK78_RS24820 0e5a5d38f048a7e05dc0bb9f7914ba0e 432 Pfam PF00571 CBS domain 200 256 4.6E-8 T 09-03-2017 IPR000644 CBS domain TK78_RS24820 0e5a5d38f048a7e05dc0bb9f7914ba0e 432 SMART SM00116 274 322 1.8 T 09-03-2017 IPR000644 CBS domain TK78_RS24820 0e5a5d38f048a7e05dc0bb9f7914ba0e 432 SMART SM00116 209 258 4.1E-4 T 09-03-2017 IPR000644 CBS domain TK78_RS24820 0e5a5d38f048a7e05dc0bb9f7914ba0e 432 SUPERFAMILY SSF54631 195 340 2.15E-35 T 09-03-2017 TK78_RS24820 0e5a5d38f048a7e05dc0bb9f7914ba0e 432 Gene3D G3DSA:3.10.580.10 186 329 2.7E-24 T 09-03-2017 TK78_RS24820 0e5a5d38f048a7e05dc0bb9f7914ba0e 432 Gene3D G3DSA:3.30.465.10 330 421 3.5E-19 T 09-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 TK78_RS24820 0e5a5d38f048a7e05dc0bb9f7914ba0e 432 SUPERFAMILY SSF56176 335 429 2.73E-13 T 09-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 TK78_RS24820 0e5a5d38f048a7e05dc0bb9f7914ba0e 432 SMART SM01091 337 423 2.6E-15 T 09-03-2017 IPR005170 Transporter-associated domain TK78_RS24820 0e5a5d38f048a7e05dc0bb9f7914ba0e 432 Pfam PF01595 Domain of unknown function DUF21 9 185 1.6E-29 T 09-03-2017 IPR002550 Domain of unknown function DUF21 TK78_RS33935 68fb4c8ecbf5fff479e66c12ee55532f 126 SUPERFAMILY SSF54593 5 124 2.06E-20 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS33935 68fb4c8ecbf5fff479e66c12ee55532f 126 Gene3D G3DSA:3.10.180.10 4 125 2.3E-24 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS33935 68fb4c8ecbf5fff479e66c12ee55532f 126 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 5 119 1.3E-7 T 09-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain TK78_RS07450 ad916f3ae03a6c8e859a4055d9518d24 261 Pfam PF00005 ABC transporter 36 184 2.9E-36 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS07450 ad916f3ae03a6c8e859a4055d9518d24 261 Gene3D G3DSA:3.40.50.300 20 256 1.8E-85 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07450 ad916f3ae03a6c8e859a4055d9518d24 261 PIRSF PIRSF039085 17 260 1.8E-113 T 09-03-2017 IPR030679 ABC-type amino acid transport system, ATPase component, HisP-type GO:0003333|GO:0015424 TK78_RS07450 ad916f3ae03a6c8e859a4055d9518d24 261 ProSitePatterns PS00211 ABC transporters family signature. 156 170 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS07450 ad916f3ae03a6c8e859a4055d9518d24 261 SMART SM00382 45 232 3.7E-18 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS07450 ad916f3ae03a6c8e859a4055d9518d24 261 SUPERFAMILY SSF52540 21 254 1.15E-79 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23670 76af481b23650f77abb6c2897265bc3c 560 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 407 547 9.0E-35 T 09-03-2017 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 TK78_RS23670 76af481b23650f77abb6c2897265bc3c 560 Gene3D G3DSA:3.40.50.1220 210 362 9.1E-45 T 09-03-2017 IPR029035 DHS-like NAD/FAD-binding domain TK78_RS23670 76af481b23650f77abb6c2897265bc3c 560 Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain 27 196 1.7E-46 T 09-03-2017 IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain GO:0030976 TK78_RS23670 76af481b23650f77abb6c2897265bc3c 560 SUPERFAMILY SSF52518 384 549 1.05E-45 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS23670 76af481b23650f77abb6c2897265bc3c 560 Gene3D G3DSA:3.40.50.970 26 200 2.7E-50 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS23670 76af481b23650f77abb6c2897265bc3c 560 Pfam PF00205 Thiamine pyrophosphate enzyme, central domain 219 348 2.0E-32 T 09-03-2017 IPR012000 Thiamine pyrophosphate enzyme, central domain GO:0000287|GO:0030976 TK78_RS23670 76af481b23650f77abb6c2897265bc3c 560 Gene3D G3DSA:3.40.50.970 383 547 9.2E-47 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS23670 76af481b23650f77abb6c2897265bc3c 560 ProSitePatterns PS00187 Thiamine pyrophosphate enzymes signature. 440 459 - T 09-03-2017 IPR000399 TPP-binding enzyme, conserved site GO:0000287|GO:0030976 TK78_RS23670 76af481b23650f77abb6c2897265bc3c 560 SUPERFAMILY SSF52518 26 201 2.85E-41 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS23670 76af481b23650f77abb6c2897265bc3c 560 SUPERFAMILY SSF52467 181 376 8.02E-38 T 09-03-2017 IPR029035 DHS-like NAD/FAD-binding domain TK78_RS23225 6dcf2780de33817e5149f5d76d5c05e0 177 Gene3D G3DSA:1.10.10.10 88 169 7.3E-28 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS23225 6dcf2780de33817e5149f5d76d5c05e0 177 ProSitePatterns PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 139 145 - T 09-03-2017 IPR001497 Methylated-DNA-[protein]-cysteine S-methyltransferase, active site GO:0003908|GO:0006281 Reactome: R-HSA-5657655 TK78_RS23225 6dcf2780de33817e5149f5d76d5c05e0 177 SUPERFAMILY SSF53155 4 89 5.69E-10 T 09-03-2017 IPR008332 Methylguanine DNA methyltransferase, ribonuclease-like domain GO:0003908|GO:0006281 Reactome: R-HSA-5657655 TK78_RS23225 6dcf2780de33817e5149f5d76d5c05e0 177 TIGRFAM TIGR00589 ogt: methylated-DNA--[protein]-cysteine S-methyltransferase 88 168 2.4E-27 T 09-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 TK78_RS23225 6dcf2780de33817e5149f5d76d5c05e0 177 Pfam PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 94 168 5.3E-26 T 09-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 TK78_RS23225 6dcf2780de33817e5149f5d76d5c05e0 177 SUPERFAMILY SSF46767 95 169 5.23E-25 T 09-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 TK78_RS32950 0c59c03e1e413e005e6b59f9b7693520 258 SUPERFAMILY SSF51658 6 253 6.68E-47 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS32950 0c59c03e1e413e005e6b59f9b7693520 258 Pfam PF07582 AP endonuclease family 2 C terminus 215 236 2.6E-5 T 09-03-2017 IPR011418 AP endonuclease, family 2, C-terminal TK78_RS32950 0c59c03e1e413e005e6b59f9b7693520 258 Gene3D G3DSA:3.20.20.150 5 255 1.2E-51 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS32950 0c59c03e1e413e005e6b59f9b7693520 258 Pfam PF01261 Xylose isomerase-like TIM barrel 26 209 4.2E-29 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS18270 4816d776de48bc3d9a1ed355bac755e1 508 Hamap MF_01931 Amidophosphoribosyltransferase [purF]. 22 475 46.186 T 09-03-2017 IPR005854 Amidophosphoribosyltransferase GO:0004044|GO:0009113 KEGG: 00230+2.4.2.14|KEGG: 00250+2.4.2.14|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|MetaCyc: PWY-7282|Reactome: R-HSA-73817 TK78_RS18270 4816d776de48bc3d9a1ed355bac755e1 508 Gene3D G3DSA:3.60.20.10 23 274 1.2E-67 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS18270 4816d776de48bc3d9a1ed355bac755e1 508 Pfam PF00156 Phosphoribosyl transferase domain 302 403 1.4E-6 T 09-03-2017 IPR000836 Phosphoribosyltransferase domain GO:0009116 TK78_RS18270 4816d776de48bc3d9a1ed355bac755e1 508 Pfam PF13522 Glutamine amidotransferase domain 85 227 1.6E-15 T 09-03-2017 TK78_RS18270 4816d776de48bc3d9a1ed355bac755e1 508 SUPERFAMILY SSF56235 23 286 3.86E-64 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS18270 4816d776de48bc3d9a1ed355bac755e1 508 PIRSF PIRSF000485 19 485 1.4E-160 T 09-03-2017 IPR005854 Amidophosphoribosyltransferase GO:0004044|GO:0009113 KEGG: 00230+2.4.2.14|KEGG: 00250+2.4.2.14|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|MetaCyc: PWY-7282|Reactome: R-HSA-73817 TK78_RS18270 4816d776de48bc3d9a1ed355bac755e1 508 TIGRFAM TIGR01134 purF: amidophosphoribosyltransferase 23 474 5.2E-157 T 09-03-2017 IPR005854 Amidophosphoribosyltransferase GO:0004044|GO:0009113 KEGG: 00230+2.4.2.14|KEGG: 00250+2.4.2.14|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|MetaCyc: PWY-7282|Reactome: R-HSA-73817 TK78_RS18270 4816d776de48bc3d9a1ed355bac755e1 508 Gene3D G3DSA:3.40.50.2020 290 456 1.6E-44 T 09-03-2017 IPR029057 Phosphoribosyltransferase-like TK78_RS18270 4816d776de48bc3d9a1ed355bac755e1 508 SUPERFAMILY SSF53271 268 482 2.23E-68 T 09-03-2017 IPR029057 Phosphoribosyltransferase-like TK78_RS18450 586279801847d14049e1f363bdf2249a 418 Pfam PF01266 FAD dependent oxidoreductase 10 397 1.5E-65 T 09-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 TK78_RS18450 586279801847d14049e1f363bdf2249a 418 Gene3D G3DSA:3.50.50.60 143 250 1.2E-30 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS18450 586279801847d14049e1f363bdf2249a 418 Gene3D G3DSA:3.50.50.60 8 91 1.2E-30 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS18450 586279801847d14049e1f363bdf2249a 418 SUPERFAMILY SSF51905 357 398 1.51E-43 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS18450 586279801847d14049e1f363bdf2249a 418 SUPERFAMILY SSF51905 8 224 1.51E-43 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS18450 586279801847d14049e1f363bdf2249a 418 Gene3D G3DSA:3.30.9.10 94 142 9.2E-7 T 09-03-2017 TK78_RS30335 c2d10bde807ff772eb57ed1796fc65cd 107 Gene3D G3DSA:1.10.8.50 50 102 8.0E-14 T 09-03-2017 TK78_RS30335 c2d10bde807ff772eb57ed1796fc65cd 107 SUPERFAMILY SSF46946 56 102 1.69E-7 T 09-03-2017 IPR010979 Ribosomal protein S13-like, H2TH GO:0003676 TK78_RS22020 608cff3de256e20749f35eebad13c900 485 ProSitePatterns PS00738 S-adenosyl-L-homocysteine hydrolase signature 1. 81 95 - T 09-03-2017 IPR020082 S-adenosyl-L-homocysteine hydrolase, conserved site GO:0004013|GO:0006730 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 TK78_RS22020 608cff3de256e20749f35eebad13c900 485 SUPERFAMILY SSF52283 7 157 1.7E-115 T 09-03-2017 TK78_RS22020 608cff3de256e20749f35eebad13c900 485 SUPERFAMILY SSF52283 406 485 1.7E-115 T 09-03-2017 TK78_RS22020 608cff3de256e20749f35eebad13c900 485 SUPERFAMILY SSF52283 195 242 1.7E-115 T 09-03-2017 TK78_RS22020 608cff3de256e20749f35eebad13c900 485 SUPERFAMILY SSF51735 243 405 2.28E-77 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS22020 608cff3de256e20749f35eebad13c900 485 Pfam PF05221 S-adenosyl-L-homocysteine hydrolase 9 484 5.1E-148 T 09-03-2017 IPR000043 Adenosylhomocysteinase GO:0004013|GO:0006730 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 TK78_RS22020 608cff3de256e20749f35eebad13c900 485 ProSitePatterns PS00739 S-adenosyl-L-homocysteine hydrolase signature 2. 265 281 - T 09-03-2017 IPR020082 S-adenosyl-L-homocysteine hydrolase, conserved site GO:0004013|GO:0006730 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 TK78_RS22020 608cff3de256e20749f35eebad13c900 485 Pfam PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 243 405 9.3E-83 T 09-03-2017 IPR015878 S-adenosyl-L-homocysteine hydrolase, NAD binding domain KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 TK78_RS22020 608cff3de256e20749f35eebad13c900 485 Gene3D G3DSA:3.40.50.720 245 404 2.8E-51 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS22020 608cff3de256e20749f35eebad13c900 485 SMART SM00997 243 405 4.5E-109 T 09-03-2017 IPR015878 S-adenosyl-L-homocysteine hydrolase, NAD binding domain KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 TK78_RS22020 608cff3de256e20749f35eebad13c900 485 SMART SM00996 9 484 0.0 T 09-03-2017 IPR000043 Adenosylhomocysteinase GO:0004013|GO:0006730 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 TK78_RS22020 608cff3de256e20749f35eebad13c900 485 Hamap MF_00563 Adenosylhomocysteinase [ahcY]. 5 477 50.041 T 09-03-2017 IPR000043 Adenosylhomocysteinase GO:0004013|GO:0006730 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 TK78_RS22020 608cff3de256e20749f35eebad13c900 485 PIRSF PIRSF001109 1 485 6.1E-194 T 09-03-2017 IPR000043 Adenosylhomocysteinase GO:0004013|GO:0006730 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 TK78_RS22020 608cff3de256e20749f35eebad13c900 485 Gene3D G3DSA:3.40.50.1480 406 485 2.7E-148 T 09-03-2017 TK78_RS22020 608cff3de256e20749f35eebad13c900 485 Gene3D G3DSA:3.40.50.1480 8 244 2.7E-148 T 09-03-2017 TK78_RS22020 608cff3de256e20749f35eebad13c900 485 TIGRFAM TIGR00936 ahcY: adenosylhomocysteinase 10 477 4.1E-192 T 09-03-2017 IPR000043 Adenosylhomocysteinase GO:0004013|GO:0006730 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 TK78_RS07910 bef26795f65c19ed626be00d2e3a2a1b 446 TIGRFAM TIGR00700 GABAtrnsam: 4-aminobutyrate transaminase 25 442 8.2E-179 T 09-03-2017 IPR004632 4-aminobutyrate aminotransferase, bacterial GO:0003867|GO:0009448 TK78_RS07910 bef26795f65c19ed626be00d2e3a2a1b 446 Gene3D G3DSA:3.40.640.10 75 323 5.5E-77 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS07910 bef26795f65c19ed626be00d2e3a2a1b 446 Gene3D G3DSA:3.90.1150.10 324 444 8.0E-38 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS07910 bef26795f65c19ed626be00d2e3a2a1b 446 SUPERFAMILY SSF53383 36 444 1.53E-121 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS07910 bef26795f65c19ed626be00d2e3a2a1b 446 Pfam PF00202 Aminotransferase class-III 36 442 1.7E-116 T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS07910 bef26795f65c19ed626be00d2e3a2a1b 446 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 256 293 - T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS29505 6c3aa9b06481a4f7c5c6802584b9edb0 302 Gene3D G3DSA:1.10.150.20 177 242 1.4E-21 T 09-03-2017 TK78_RS29505 6c3aa9b06481a4f7c5c6802584b9edb0 302 Gene3D G3DSA:3.40.50.1010 1 176 7.4E-47 T 09-03-2017 IPR029060 PIN domain-like TK78_RS29505 6c3aa9b06481a4f7c5c6802584b9edb0 302 SUPERFAMILY SSF88723 1 161 2.03E-37 T 09-03-2017 IPR029060 PIN domain-like TK78_RS29505 6c3aa9b06481a4f7c5c6802584b9edb0 302 SMART SM00279 181 216 1.3E-10 T 09-03-2017 IPR008918 Helix-hairpin-helix motif, class 2 GO:0003677|GO:0003824 TK78_RS29505 6c3aa9b06481a4f7c5c6802584b9edb0 302 SUPERFAMILY SSF47807 183 293 5.98E-22 T 09-03-2017 IPR020045 5'-3' exonuclease, C-terminal domain GO:0003677|GO:0003824 TK78_RS29505 6c3aa9b06481a4f7c5c6802584b9edb0 302 SMART SM00475 1 273 7.9E-79 T 09-03-2017 IPR002421 5'-3' exonuclease, N-terminal GO:0003677 TK78_RS29505 6c3aa9b06481a4f7c5c6802584b9edb0 302 Pfam PF02739 5'-3' exonuclease, N-terminal resolvase-like domain 1 178 2.5E-46 T 09-03-2017 IPR020046 5'-3' exonuclease, alpha-helical arch, N-terminal GO:0003677 TK78_RS29505 6c3aa9b06481a4f7c5c6802584b9edb0 302 Pfam PF01367 5'-3' exonuclease, C-terminal SAM fold 183 265 7.5E-20 T 09-03-2017 IPR020045 5'-3' exonuclease, C-terminal domain GO:0003677|GO:0003824 TK78_RS15650 e4923d94242ed6ca4624ab252f6b3318 277 SUPERFAMILY SSF53335 42 247 9.69E-30 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS15650 e4923d94242ed6ca4624ab252f6b3318 277 Gene3D G3DSA:3.40.50.150 200 234 2.1E-21 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS15650 e4923d94242ed6ca4624ab252f6b3318 277 Gene3D G3DSA:3.40.50.150 17 166 2.1E-21 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS15650 e4923d94242ed6ca4624ab252f6b3318 277 Pfam PF13649 Methyltransferase domain 59 157 1.7E-11 T 09-03-2017 TK78_RS21125 b06f11a3d249a374506e375b75d8dcfe 269 Gene3D G3DSA:3.40.50.1820 13 218 3.0E-20 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS21125 b06f11a3d249a374506e375b75d8dcfe 269 Pfam PF05057 Putative serine esterase (DUF676) 23 154 6.2E-11 T 09-03-2017 IPR007751 Domain of unknown function DUF676, lipase-like TK78_RS21125 b06f11a3d249a374506e375b75d8dcfe 269 SUPERFAMILY SSF53474 21 219 2.67E-14 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS33810 d08336d2ee61e870620c7d43a871da8c 547 Pfam PF02878 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I 39 179 4.0E-35 T 09-03-2017 IPR005844 Alpha-D-phosphohexomutase, alpha/beta/alpha domain I GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS33810 d08336d2ee61e870620c7d43a871da8c 547 SUPERFAMILY SSF53738 306 448 5.89E-33 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS33810 d08336d2ee61e870620c7d43a871da8c 547 Gene3D G3DSA:3.40.120.10 226 310 1.3E-43 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS33810 d08336d2ee61e870620c7d43a871da8c 547 Pfam PF00408 Phosphoglucomutase/phosphomannomutase, C-terminal domain 481 539 1.4E-7 T 09-03-2017 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS33810 d08336d2ee61e870620c7d43a871da8c 547 Gene3D G3DSA:3.40.120.10 28 225 6.2E-58 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS33810 d08336d2ee61e870620c7d43a871da8c 547 SUPERFAMILY SSF55957 434 545 2.43E-19 T 09-03-2017 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS33810 d08336d2ee61e870620c7d43a871da8c 547 Gene3D G3DSA:3.30.310.50 467 545 1.4E-27 T 09-03-2017 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS33810 d08336d2ee61e870620c7d43a871da8c 547 SUPERFAMILY SSF53738 210 317 1.29E-5 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS33810 d08336d2ee61e870620c7d43a871da8c 547 Pfam PF02880 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III 321 440 2.1E-28 T 09-03-2017 IPR005846 Alpha-D-phosphohexomutase, alpha/beta/alpha domain III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS33810 d08336d2ee61e870620c7d43a871da8c 547 Pfam PF02879 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II 210 317 6.6E-11 T 09-03-2017 IPR005845 Alpha-D-phosphohexomutase, alpha/beta/alpha domain II GO:0005975 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS33810 d08336d2ee61e870620c7d43a871da8c 547 SUPERFAMILY SSF53738 24 235 8.01E-49 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS33810 d08336d2ee61e870620c7d43a871da8c 547 TIGRFAM TIGR01132 pgm: phosphoglucomutase, alpha-D-glucose phosphate-specific 2 545 3.9E-283 T 09-03-2017 IPR005852 Phosphoglucomutase, alpha-D-glucose specific GO:0004614|GO:0005975 KEGG: 00010+5.4.2.2|KEGG: 00030+5.4.2.2|KEGG: 00052+5.4.2.2|KEGG: 00230+5.4.2.2|KEGG: 00500+5.4.2.2|KEGG: 00520+5.4.2.2|KEGG: 00521+5.4.2.2|MetaCyc: PWY-2723|MetaCyc: PWY-3801|MetaCyc: PWY-5384|MetaCyc: PWY-5661|MetaCyc: PWY-5940|MetaCyc: PWY-5941|MetaCyc: PWY-622|MetaCyc: PWY-6731|MetaCyc: PWY-6737|MetaCyc: PWY-7238|MetaCyc: PWY-7343 TK78_RS33810 d08336d2ee61e870620c7d43a871da8c 547 Gene3D G3DSA:3.40.120.10 311 444 9.1E-34 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS33810 d08336d2ee61e870620c7d43a871da8c 547 ProSitePatterns PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 140 149 - T 09-03-2017 IPR016066 Alpha-D-phosphohexomutase, conserved site GO:0000287 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS25720 67fef0e481e5349967dab4e68d7d6231 237 ProSitePatterns PS00332 Copper/Zinc superoxide dismutase signature 2. 218 229 - T 09-03-2017 IPR018152 Superoxide dismutase, copper/zinc, binding site GO:0004784|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 TK78_RS25720 67fef0e481e5349967dab4e68d7d6231 237 Gene3D G3DSA:2.60.40.200 125 227 2.5E-6 T 09-03-2017 IPR001424 Superoxide dismutase, copper/zinc binding domain GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 TK78_RS25720 67fef0e481e5349967dab4e68d7d6231 237 SUPERFAMILY SSF49329 121 226 6.66E-13 T 09-03-2017 IPR001424 Superoxide dismutase, copper/zinc binding domain GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 TK78_RS25720 67fef0e481e5349967dab4e68d7d6231 237 Pfam PF00080 Copper/zinc superoxide dismutase (SODC) 120 226 5.7E-9 T 09-03-2017 IPR001424 Superoxide dismutase, copper/zinc binding domain GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 TK78_RS13900 5aba690694c57b90c6bce557555ab7b4 392 Gene3D G3DSA:3.40.50.720 237 316 9.3E-5 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS13900 5aba690694c57b90c6bce557555ab7b4 392 Pfam PF13738 Pyridine nucleotide-disulphide oxidoreductase 21 213 1.0E-26 T 09-03-2017 TK78_RS13900 5aba690694c57b90c6bce557555ab7b4 392 Gene3D G3DSA:3.50.50.60 18 217 8.6E-49 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS13900 5aba690694c57b90c6bce557555ab7b4 392 SUPERFAMILY SSF51905 180 390 6.95E-8 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS13900 5aba690694c57b90c6bce557555ab7b4 392 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 19 38 1.0E-6 T 09-03-2017 TK78_RS13900 5aba690694c57b90c6bce557555ab7b4 392 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 181 199 1.0E-6 T 09-03-2017 TK78_RS13900 5aba690694c57b90c6bce557555ab7b4 392 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 138 146 2.4E-10 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS13900 5aba690694c57b90c6bce557555ab7b4 392 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 18 40 2.4E-10 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS13900 5aba690694c57b90c6bce557555ab7b4 392 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 177 201 2.4E-10 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS13900 5aba690694c57b90c6bce557555ab7b4 392 SUPERFAMILY SSF51905 17 254 1.0E-46 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS01195 c8e25f614df96cab664208d7102a378f 454 Gene3D G3DSA:3.40.190.10 51 173 1.8E-21 T 09-03-2017 TK78_RS01195 c8e25f614df96cab664208d7102a378f 454 Pfam PF01547 Bacterial extracellular solute-binding protein 55 347 1.3E-47 T 09-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 TK78_RS01195 c8e25f614df96cab664208d7102a378f 454 Gene3D G3DSA:3.40.190.10 174 370 9.6E-45 T 09-03-2017 TK78_RS01195 c8e25f614df96cab664208d7102a378f 454 SUPERFAMILY SSF53850 40 450 1.29E-66 T 09-03-2017 TK78_RS29305 4d88b1af7dde7eb78cee3fdd3b8e4ba6 223 Gene3D G3DSA:3.40.50.2300 3 125 3.4E-39 T 09-03-2017 TK78_RS29305 4d88b1af7dde7eb78cee3fdd3b8e4ba6 223 Pfam PF00072 Response regulator receiver domain 5 119 1.3E-27 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS29305 4d88b1af7dde7eb78cee3fdd3b8e4ba6 223 SMART SM00421 155 212 5.4E-29 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS29305 4d88b1af7dde7eb78cee3fdd3b8e4ba6 223 ProSitePatterns PS00622 LuxR-type HTH domain signature. 172 199 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS29305 4d88b1af7dde7eb78cee3fdd3b8e4ba6 223 SUPERFAMILY SSF52172 3 137 7.97E-36 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS29305 4d88b1af7dde7eb78cee3fdd3b8e4ba6 223 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 158 172 1.9E-15 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS29305 4d88b1af7dde7eb78cee3fdd3b8e4ba6 223 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 172 188 1.9E-15 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS29305 4d88b1af7dde7eb78cee3fdd3b8e4ba6 223 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 188 200 1.9E-15 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS29305 4d88b1af7dde7eb78cee3fdd3b8e4ba6 223 SMART SM00448 3 118 5.1E-37 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS29305 4d88b1af7dde7eb78cee3fdd3b8e4ba6 223 SUPERFAMILY SSF46894 146 218 8.5E-24 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS29305 4d88b1af7dde7eb78cee3fdd3b8e4ba6 223 Pfam PF00196 Bacterial regulatory proteins, luxR family 157 212 1.3E-21 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS29305 4d88b1af7dde7eb78cee3fdd3b8e4ba6 223 Gene3D G3DSA:1.10.10.10 126 220 1.6E-35 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS00005 c16ad78e9d90691ef5f73adaa40ac93e 796 Pfam PF00271 Helicase conserved C-terminal domain 329 400 4.5E-7 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS00005 c16ad78e9d90691ef5f73adaa40ac93e 796 SMART SM00487 1 228 5.9E-18 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS00005 c16ad78e9d90691ef5f73adaa40ac93e 796 SUPERFAMILY SSF52540 34 192 2.02E-29 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS00005 c16ad78e9d90691ef5f73adaa40ac93e 796 SUPERFAMILY SSF52540 258 407 2.02E-29 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS00005 c16ad78e9d90691ef5f73adaa40ac93e 796 Pfam PF03457 Helicase associated domain 508 570 4.1E-15 T 09-03-2017 IPR005114 Helicase-associated TK78_RS00005 c16ad78e9d90691ef5f73adaa40ac93e 796 Pfam PF03457 Helicase associated domain 730 792 1.6E-7 T 09-03-2017 IPR005114 Helicase-associated TK78_RS00005 c16ad78e9d90691ef5f73adaa40ac93e 796 Pfam PF03457 Helicase associated domain 645 709 3.1E-7 T 09-03-2017 IPR005114 Helicase-associated TK78_RS00005 c16ad78e9d90691ef5f73adaa40ac93e 796 Gene3D G3DSA:3.40.50.300 3 194 7.8E-22 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS00005 c16ad78e9d90691ef5f73adaa40ac93e 796 Gene3D G3DSA:3.40.50.300 280 403 1.1E-11 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS00005 c16ad78e9d90691ef5f73adaa40ac93e 796 Pfam PF04851 Type III restriction enzyme, res subunit 3 190 3.8E-17 T 09-03-2017 IPR006935 Helicase/UvrB, N-terminal GO:0003677|GO:0005524|GO:0016787 TK78_RS34870 c16ad78e9d90691ef5f73adaa40ac93e 796 Pfam PF00271 Helicase conserved C-terminal domain 329 400 4.5E-7 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS34870 c16ad78e9d90691ef5f73adaa40ac93e 796 SMART SM00487 1 228 5.9E-18 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS34870 c16ad78e9d90691ef5f73adaa40ac93e 796 SUPERFAMILY SSF52540 34 192 2.02E-29 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS34870 c16ad78e9d90691ef5f73adaa40ac93e 796 SUPERFAMILY SSF52540 258 407 2.02E-29 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS34870 c16ad78e9d90691ef5f73adaa40ac93e 796 Pfam PF03457 Helicase associated domain 508 570 4.1E-15 T 09-03-2017 IPR005114 Helicase-associated TK78_RS34870 c16ad78e9d90691ef5f73adaa40ac93e 796 Pfam PF03457 Helicase associated domain 730 792 1.6E-7 T 09-03-2017 IPR005114 Helicase-associated TK78_RS34870 c16ad78e9d90691ef5f73adaa40ac93e 796 Pfam PF03457 Helicase associated domain 645 709 3.1E-7 T 09-03-2017 IPR005114 Helicase-associated TK78_RS34870 c16ad78e9d90691ef5f73adaa40ac93e 796 Gene3D G3DSA:3.40.50.300 3 194 7.8E-22 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS34870 c16ad78e9d90691ef5f73adaa40ac93e 796 Gene3D G3DSA:3.40.50.300 280 403 1.1E-11 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS34870 c16ad78e9d90691ef5f73adaa40ac93e 796 Pfam PF04851 Type III restriction enzyme, res subunit 3 190 3.8E-17 T 09-03-2017 IPR006935 Helicase/UvrB, N-terminal GO:0003677|GO:0005524|GO:0016787 TK78_RS06920 7ff63b92ff8087c2be1f08af5e1c08be 414 SUPERFAMILY SSF47384 178 260 6.47E-15 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS06920 7ff63b92ff8087c2be1f08af5e1c08be 414 SMART SM00304 141 194 1.5E-13 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS06920 7ff63b92ff8087c2be1f08af5e1c08be 414 Pfam PF00672 HAMP domain 122 191 4.7E-15 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS06920 7ff63b92ff8087c2be1f08af5e1c08be 414 SUPERFAMILY SSF158472 142 191 6.67E-9 T 09-03-2017 TK78_RS06920 7ff63b92ff8087c2be1f08af5e1c08be 414 Gene3D G3DSA:1.10.287.130 185 257 1.7E-10 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS06920 7ff63b92ff8087c2be1f08af5e1c08be 414 Pfam PF00512 His Kinase A (phospho-acceptor) domain 196 260 2.1E-10 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS06920 7ff63b92ff8087c2be1f08af5e1c08be 414 SUPERFAMILY SSF55874 252 414 7.99E-33 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS06920 7ff63b92ff8087c2be1f08af5e1c08be 414 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 307 414 6.3E-16 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS06920 7ff63b92ff8087c2be1f08af5e1c08be 414 SMART SM00387 303 414 2.8E-25 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS06920 7ff63b92ff8087c2be1f08af5e1c08be 414 PRINTS PR00344 Bacterial sensor protein C-terminal signature 400 413 5.9E-10 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS06920 7ff63b92ff8087c2be1f08af5e1c08be 414 PRINTS PR00344 Bacterial sensor protein C-terminal signature 359 369 5.9E-10 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS06920 7ff63b92ff8087c2be1f08af5e1c08be 414 PRINTS PR00344 Bacterial sensor protein C-terminal signature 376 394 5.9E-10 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS06920 7ff63b92ff8087c2be1f08af5e1c08be 414 PRINTS PR00344 Bacterial sensor protein C-terminal signature 341 355 5.9E-10 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS06920 7ff63b92ff8087c2be1f08af5e1c08be 414 SMART SM00388 195 261 1.1E-12 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS06920 7ff63b92ff8087c2be1f08af5e1c08be 414 Gene3D G3DSA:3.30.565.10 263 414 4.0E-34 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS30130 1a57716aeeb6552e74f55657d4f6de27 596 Pfam PF02355 Protein export membrane protein 381 556 6.1E-12 T 09-03-2017 IPR022813 Protein-export membrane protein SecD/SecF, archaeal and bacterial TK78_RS30130 1a57716aeeb6552e74f55657d4f6de27 596 Pfam PF07549 SecD/SecF GG Motif 40 61 1.6E-4 T 09-03-2017 IPR022646 Protein-export membrane protein SecD/SecF/SecDF, conserved site TK78_RS30130 1a57716aeeb6552e74f55657d4f6de27 596 Hamap MF_01463_B Protein translocase subunit SecD [secD]. 9 566 38.187 T 09-03-2017 IPR005791 Protein translocase subunit SecD GO:0006886|GO:0015450 TK78_RS30130 1a57716aeeb6552e74f55657d4f6de27 596 TIGRFAM TIGR01129 secD: protein-export membrane protein SecD 45 552 5.9E-104 T 09-03-2017 IPR005791 Protein translocase subunit SecD GO:0006886|GO:0015450 TK78_RS30130 1a57716aeeb6552e74f55657d4f6de27 596 SUPERFAMILY SSF82866 358 559 4.19E-32 T 09-03-2017 TK78_RS30130 1a57716aeeb6552e74f55657d4f6de27 596 TIGRFAM TIGR00916 2A0604s01: protein-export membrane protein, SecD/SecF family 307 544 1.9E-62 T 09-03-2017 IPR022645 Protein-export membrane protein SecD/SecF, bacterial TK78_RS30130 1a57716aeeb6552e74f55657d4f6de27 596 Gene3D G3DSA:1.20.1640.10 362 560 3.3E-22 T 09-03-2017 TK78_RS08295 c8694aa45c4ee94eec9460122e5ae8db 734 Gene3D G3DSA:2.40.50.140 44 139 1.2E-15 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS08295 c8694aa45c4ee94eec9460122e5ae8db 734 SUPERFAMILY SSF52540 534 632 4.55E-38 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08295 c8694aa45c4ee94eec9460122e5ae8db 734 SUPERFAMILY SSF52540 400 505 4.55E-38 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08295 c8694aa45c4ee94eec9460122e5ae8db 734 SUPERFAMILY SSF50249 12 181 7.2E-30 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS08295 c8694aa45c4ee94eec9460122e5ae8db 734 TIGRFAM TIGR00643 recG: ATP-dependent DNA helicase RecG 25 699 4.0E-201 T 09-03-2017 IPR004609 ATP-dependent DNA helicase RecG GO:0004003|GO:0006281|GO:0006310 TK78_RS08295 c8694aa45c4ee94eec9460122e5ae8db 734 Gene3D G3DSA:3.40.50.300 464 670 2.7E-44 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08295 c8694aa45c4ee94eec9460122e5ae8db 734 SUPERFAMILY SSF52540 187 461 5.94E-57 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08295 c8694aa45c4ee94eec9460122e5ae8db 734 Gene3D G3DSA:3.40.50.300 256 463 1.0E-60 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08295 c8694aa45c4ee94eec9460122e5ae8db 734 Pfam PF00271 Helicase conserved C-terminal domain 544 621 1.7E-19 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS08295 c8694aa45c4ee94eec9460122e5ae8db 734 SMART SM00487 266 480 1.3E-32 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS08295 c8694aa45c4ee94eec9460122e5ae8db 734 Pfam PF17191 RecG wedge domain 13 168 7.6E-9 T 09-03-2017 IPR033454 RecG, wedge domain TK78_RS08295 c8694aa45c4ee94eec9460122e5ae8db 734 SMART SM00490 537 622 1.6E-23 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS08295 c8694aa45c4ee94eec9460122e5ae8db 734 Pfam PF00270 DEAD/DEAH box helicase 292 444 1.9E-16 T 09-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 TK78_RS17990 2d807d40ee93b7ae788fa28421e3018c 250 Pfam PF02571 Precorrin-6x reductase CbiJ/CobK 2 243 3.4E-71 T 09-03-2017 IPR003723 Precorrin-6x reductase GO:0009236|GO:0016994|GO:0055114 TK78_RS17990 2d807d40ee93b7ae788fa28421e3018c 250 TIGRFAM TIGR00715 precor6x_red: precorrin-6x reductase 2 246 1.2E-44 T 09-03-2017 IPR003723 Precorrin-6x reductase GO:0009236|GO:0016994|GO:0055114 TK78_RS17990 2d807d40ee93b7ae788fa28421e3018c 250 Gene3D G3DSA:3.40.50.2300 184 237 3.4E-5 T 09-03-2017 TK78_RS10245 e4bb826cfef34dc78df9f75779ed982a 309 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 85 305 4.2E-38 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS10245 e4bb826cfef34dc78df9f75779ed982a 309 Gene3D G3DSA:1.10.601.10 77 156 1.8E-27 T 09-03-2017 TK78_RS10245 e4bb826cfef34dc78df9f75779ed982a 309 Pfam PF04539 Sigma-70 region 3 172 229 2.0E-16 T 09-03-2017 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS10245 e4bb826cfef34dc78df9f75779ed982a 309 SUPERFAMILY SSF88659 162 236 9.16E-17 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS10245 e4bb826cfef34dc78df9f75779ed982a 309 SUPERFAMILY SSF88946 57 158 7.59E-33 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS10245 e4bb826cfef34dc78df9f75779ed982a 309 Gene3D G3DSA:1.10.10.10 246 305 6.3E-11 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS10245 e4bb826cfef34dc78df9f75779ed982a 309 Pfam PF04542 Sigma-70 region 2 89 158 3.2E-21 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS10245 e4bb826cfef34dc78df9f75779ed982a 309 TIGRFAM TIGR02980 SigBFG: RNA polymerase sigma-70 factor, sigma-B/F/G subfamily 83 305 1.4E-96 T 09-03-2017 IPR014322 RNA polymerase sigma-B/F/G type GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS10245 e4bb826cfef34dc78df9f75779ed982a 309 PRINTS PR00046 Major sigma-70 factor signature 275 290 9.8E-10 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS10245 e4bb826cfef34dc78df9f75779ed982a 309 PRINTS PR00046 Major sigma-70 factor signature 290 301 9.8E-10 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS10245 e4bb826cfef34dc78df9f75779ed982a 309 PRINTS PR00046 Major sigma-70 factor signature 137 145 9.8E-10 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS10245 e4bb826cfef34dc78df9f75779ed982a 309 PRINTS PR00046 Major sigma-70 factor signature 258 270 9.8E-10 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS10245 e4bb826cfef34dc78df9f75779ed982a 309 PRINTS PR00046 Major sigma-70 factor signature 113 126 9.8E-10 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS10245 e4bb826cfef34dc78df9f75779ed982a 309 SUPERFAMILY SSF88659 226 305 3.74E-17 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS10245 e4bb826cfef34dc78df9f75779ed982a 309 Gene3D G3DSA:1.10.10.10 157 212 4.3E-24 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS10245 e4bb826cfef34dc78df9f75779ed982a 309 Pfam PF04545 Sigma-70, region 4 254 303 2.1E-16 T 09-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS13150 9bb20b8f77af733dfbf50e1b9c0dda83 278 SUPERFAMILY SSF50249 3 126 1.68E-48 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS13150 9bb20b8f77af733dfbf50e1b9c0dda83 278 Pfam PF00181 Ribosomal Proteins L2, RNA binding domain 42 118 1.1E-31 T 09-03-2017 IPR022666 Ribosomal Proteins L2, RNA binding domain GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13150 9bb20b8f77af733dfbf50e1b9c0dda83 278 Gene3D G3DSA:4.10.950.10 197 273 3.8E-32 T 09-03-2017 IPR014726 Ribosomal protein L2, domain 3 TK78_RS13150 9bb20b8f77af733dfbf50e1b9c0dda83 278 SMART SM01382 125 253 4.9E-89 T 09-03-2017 IPR022669 Ribosomal protein L2, C-terminal GO:0003735|GO:0005840|GO:0006412 TK78_RS13150 9bb20b8f77af733dfbf50e1b9c0dda83 278 Pfam PF03947 Ribosomal Proteins L2, C-terminal domain 126 251 2.0E-55 T 09-03-2017 IPR022669 Ribosomal protein L2, C-terminal GO:0003735|GO:0005840|GO:0006412 TK78_RS13150 9bb20b8f77af733dfbf50e1b9c0dda83 278 SUPERFAMILY SSF50104 127 271 6.62E-56 T 09-03-2017 IPR008991 Translation protein SH3-like domain TK78_RS13150 9bb20b8f77af733dfbf50e1b9c0dda83 278 Gene3D G3DSA:2.40.50.140 1 115 3.4E-51 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS13150 9bb20b8f77af733dfbf50e1b9c0dda83 278 SMART SM01383 42 119 5.5E-39 T 09-03-2017 IPR002171 Ribosomal protein L2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13150 9bb20b8f77af733dfbf50e1b9c0dda83 278 Hamap MF_01320_B 50S ribosomal protein L2 [rplB]. 1 273 47.644 T 09-03-2017 IPR005880 Ribosomal protein L2, bacterial/organellar-type GO:0003723|GO:0003735|GO:0006412|GO:0015934|GO:0016740 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13150 9bb20b8f77af733dfbf50e1b9c0dda83 278 PIRSF PIRSF002158 4 275 2.3E-95 T 09-03-2017 IPR002171 Ribosomal protein L2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13150 9bb20b8f77af733dfbf50e1b9c0dda83 278 TIGRFAM TIGR01171 rplB_bact: ribosomal protein uL2 3 273 1.4E-127 T 09-03-2017 IPR005880 Ribosomal protein L2, bacterial/organellar-type GO:0003723|GO:0003735|GO:0006412|GO:0015934|GO:0016740 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13150 9bb20b8f77af733dfbf50e1b9c0dda83 278 ProSitePatterns PS00467 Ribosomal protein L2 signature. 219 230 - T 09-03-2017 IPR022671 Ribosomal protein L2, conserved site GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13150 9bb20b8f77af733dfbf50e1b9c0dda83 278 Gene3D G3DSA:2.30.30.30 120 196 1.7E-30 T 09-03-2017 IPR014722 Ribosomal protein L2 domain 2 TK78_RS14340 5d3eb4b45228b30b3fe673af718ae893 133 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 6 86 2.2E-6 T 09-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS14340 5d3eb4b45228b30b3fe673af718ae893 133 TIGRFAM TIGR03666 Rv2061_F420: PPOX class probable F420-dependent enzyme, Rv2061 family 5 131 1.4E-35 T 09-03-2017 IPR019965 PPOX class F420-dependent enzyme, family Rv2061, putative TK78_RS14340 5d3eb4b45228b30b3fe673af718ae893 133 SUPERFAMILY SSF50475 14 108 1.12E-13 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS14340 5d3eb4b45228b30b3fe673af718ae893 133 Gene3D G3DSA:2.30.110.10 15 103 7.5E-8 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS16590 e1ea39cedce4c38cd846b4a910c0d3de 288 Gene3D G3DSA:1.10.10.10 226 285 4.3E-9 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS16590 e1ea39cedce4c38cd846b4a910c0d3de 288 SUPERFAMILY SSF88659 140 215 3.1E-14 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16590 e1ea39cedce4c38cd846b4a910c0d3de 288 ProSitePatterns PS00715 Sigma-70 factors family signature 1. 91 104 - T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16590 e1ea39cedce4c38cd846b4a910c0d3de 288 SUPERFAMILY SSF88946 59 136 6.8E-30 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16590 e1ea39cedce4c38cd846b4a910c0d3de 288 Pfam PF04545 Sigma-70, region 4 234 283 1.4E-17 T 09-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16590 e1ea39cedce4c38cd846b4a910c0d3de 288 Gene3D G3DSA:1.10.601.10 61 134 8.6E-24 T 09-03-2017 TK78_RS16590 e1ea39cedce4c38cd846b4a910c0d3de 288 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 64 284 2.9E-35 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16590 e1ea39cedce4c38cd846b4a910c0d3de 288 Pfam PF04539 Sigma-70 region 3 148 213 9.0E-11 T 09-03-2017 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16590 e1ea39cedce4c38cd846b4a910c0d3de 288 SUPERFAMILY SSF88659 203 285 1.2E-16 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16590 e1ea39cedce4c38cd846b4a910c0d3de 288 TIGRFAM TIGR02980 SigBFG: RNA polymerase sigma-70 factor, sigma-B/F/G subfamily 62 284 2.2E-94 T 09-03-2017 IPR014322 RNA polymerase sigma-B/F/G type GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16590 e1ea39cedce4c38cd846b4a910c0d3de 288 Gene3D G3DSA:1.10.10.10 135 190 2.6E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS16590 e1ea39cedce4c38cd846b4a910c0d3de 288 Pfam PF04542 Sigma-70 region 2 67 136 1.3E-17 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16590 e1ea39cedce4c38cd846b4a910c0d3de 288 PRINTS PR00046 Major sigma-70 factor signature 238 250 2.1E-10 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16590 e1ea39cedce4c38cd846b4a910c0d3de 288 PRINTS PR00046 Major sigma-70 factor signature 91 104 2.1E-10 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16590 e1ea39cedce4c38cd846b4a910c0d3de 288 PRINTS PR00046 Major sigma-70 factor signature 255 270 2.1E-10 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS19060 dcb7655b836994fe52bcf953c958456d 226 Pfam PF00072 Response regulator receiver domain 4 113 9.5E-28 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS19060 dcb7655b836994fe52bcf953c958456d 226 Gene3D G3DSA:1.10.10.10 128 225 5.3E-36 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS19060 dcb7655b836994fe52bcf953c958456d 226 Pfam PF00486 Transcriptional regulatory protein, C terminal 149 224 1.3E-27 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS19060 dcb7655b836994fe52bcf953c958456d 226 SMART SM00448 2 112 2.3E-44 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS19060 dcb7655b836994fe52bcf953c958456d 226 Gene3D G3DSA:3.40.50.2300 3 121 3.3E-40 T 09-03-2017 TK78_RS19060 dcb7655b836994fe52bcf953c958456d 226 SUPERFAMILY SSF46894 125 225 2.04E-31 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS19060 dcb7655b836994fe52bcf953c958456d 226 SMART SM00862 148 224 7.5E-30 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS19060 dcb7655b836994fe52bcf953c958456d 226 SUPERFAMILY SSF52172 3 124 3.42E-41 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS31925 616b5168d90f82004b3e7bd637c3a418 102 TIGRFAM TIGR03930 WXG100_ESAT6: WXG100 family type VII secretion target 6 92 1.4E-13 T 09-03-2017 IPR010310 Type VII secretion system ESAT-6-like TK78_RS31925 616b5168d90f82004b3e7bd637c3a418 102 Pfam PF06013 Proteins of 100 residues with WXG 6 84 5.0E-11 T 09-03-2017 IPR010310 Type VII secretion system ESAT-6-like TK78_RS31925 616b5168d90f82004b3e7bd637c3a418 102 SUPERFAMILY SSF140453 5 97 9.29E-19 T 09-03-2017 IPR010310 Type VII secretion system ESAT-6-like TK78_RS31925 616b5168d90f82004b3e7bd637c3a418 102 Gene3D G3DSA:1.10.287.1060 6 97 4.0E-19 T 09-03-2017 TK78_RS07600 6a569d7e099617f76c19e516450d56a3 227 SUPERFAMILY SSF52172 3 144 1.99E-37 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS07600 6a569d7e099617f76c19e516450d56a3 227 SMART SM00448 5 119 7.4E-31 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS07600 6a569d7e099617f76c19e516450d56a3 227 Pfam PF00072 Response regulator receiver domain 7 119 1.5E-24 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS07600 6a569d7e099617f76c19e516450d56a3 227 Gene3D G3DSA:3.40.50.2300 3 126 7.9E-36 T 09-03-2017 TK78_RS12495 ecbc15953fa335567ba4b3801e8b1c14 218 SUPERFAMILY SSF53328 12 210 1.57E-56 T 09-03-2017 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 TK78_RS12495 ecbc15953fa335567ba4b3801e8b1c14 218 Pfam PF00551 Formyl transferase 12 196 1.0E-51 T 09-03-2017 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 TK78_RS12495 ecbc15953fa335567ba4b3801e8b1c14 218 ProSitePatterns PS00373 Phosphoribosylglycinamide formyltransferase active site. 145 168 - T 09-03-2017 IPR001555 Phosphoribosylglycinamide formyltransferase, active site KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 TK78_RS12495 ecbc15953fa335567ba4b3801e8b1c14 218 Hamap MF_01930 Phosphoribosylglycinamide formyltransferase [purN]. 12 202 29.177 T 09-03-2017 IPR004607 Phosphoribosylglycinamide formyltransferase GO:0004644|GO:0006189 KEGG: 00230+2.1.2.2|KEGG: 00670+2.1.2.2|MetaCyc: PWY-6121|MetaCyc: PWY-6613|Reactome: R-HSA-73817 TK78_RS12495 ecbc15953fa335567ba4b3801e8b1c14 218 TIGRFAM TIGR00639 PurN: phosphoribosylglycinamide formyltransferase 11 206 2.2E-68 T 09-03-2017 IPR004607 Phosphoribosylglycinamide formyltransferase GO:0004644|GO:0006189 KEGG: 00230+2.1.2.2|KEGG: 00670+2.1.2.2|MetaCyc: PWY-6121|MetaCyc: PWY-6613|Reactome: R-HSA-73817 TK78_RS12495 ecbc15953fa335567ba4b3801e8b1c14 218 Gene3D G3DSA:3.40.50.170 11 205 1.5E-68 T 09-03-2017 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 TK78_RS10590 68b2810b544cc9e261b804e31b74ba4e 84 SUPERFAMILY SSF52833 4 73 1.01E-14 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS10590 68b2810b544cc9e261b804e31b74ba4e 84 Pfam PF00462 Glutaredoxin 5 60 5.4E-12 T 09-03-2017 IPR002109 Glutaredoxin GO:0009055|GO:0015035|GO:0045454 TK78_RS10590 68b2810b544cc9e261b804e31b74ba4e 84 ProSitePatterns PS00194 Thioredoxin family active site. 5 23 - T 09-03-2017 IPR017937 Thioredoxin, conserved site GO:0045454 TK78_RS10590 68b2810b544cc9e261b804e31b74ba4e 84 Gene3D G3DSA:3.40.30.10 4 83 2.4E-19 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS04965 6b950bafa5944e92d8549344a5adb487 227 PRINTS PR00111 Alpha/beta hydrolase fold signature 93 106 8.3E-9 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS04965 6b950bafa5944e92d8549344a5adb487 227 PRINTS PR00111 Alpha/beta hydrolase fold signature 50 65 8.3E-9 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS04965 6b950bafa5944e92d8549344a5adb487 227 PRINTS PR00111 Alpha/beta hydrolase fold signature 107 120 8.3E-9 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS04965 6b950bafa5944e92d8549344a5adb487 227 Gene3D G3DSA:3.40.50.1820 3 136 5.9E-42 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04965 6b950bafa5944e92d8549344a5adb487 227 Gene3D G3DSA:3.40.50.1820 137 225 1.3E-9 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04965 6b950bafa5944e92d8549344a5adb487 227 SUPERFAMILY SSF53474 5 226 3.65E-52 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04965 6b950bafa5944e92d8549344a5adb487 227 Pfam PF00561 alpha/beta hydrolase fold 26 126 3.6E-21 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS23535 f3465e6090aa3ef627bea7156d1794d6 139 SUPERFAMILY SSF46689 59 109 2.24E-11 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS23535 f3465e6090aa3ef627bea7156d1794d6 139 Pfam PF12833 Helix-turn-helix domain 29 108 7.0E-23 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS23535 f3465e6090aa3ef627bea7156d1794d6 139 SUPERFAMILY SSF46689 8 57 7.17E-10 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS23535 f3465e6090aa3ef627bea7156d1794d6 139 SMART SM00342 23 106 2.5E-30 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS23535 f3465e6090aa3ef627bea7156d1794d6 139 Gene3D G3DSA:1.10.10.60 62 111 1.9E-14 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS23535 f3465e6090aa3ef627bea7156d1794d6 139 Gene3D G3DSA:1.10.10.60 8 61 2.9E-16 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS24270 da8b3e2b400b48da40b9d3e11e5f839a 259 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 146 174 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS24270 da8b3e2b400b48da40b9d3e11e5f839a 259 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 88 99 2.5E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS24270 da8b3e2b400b48da40b9d3e11e5f839a 259 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 159 178 2.5E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS24270 da8b3e2b400b48da40b9d3e11e5f839a 259 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 139 147 2.5E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS24270 da8b3e2b400b48da40b9d3e11e5f839a 259 SUPERFAMILY SSF51735 5 253 9.38E-72 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS24270 da8b3e2b400b48da40b9d3e11e5f839a 259 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 215 235 2.9E-39 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS24270 da8b3e2b400b48da40b9d3e11e5f839a 259 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 180 197 2.9E-39 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS24270 da8b3e2b400b48da40b9d3e11e5f839a 259 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 133 149 2.9E-39 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS24270 da8b3e2b400b48da40b9d3e11e5f839a 259 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 88 99 2.9E-39 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS24270 da8b3e2b400b48da40b9d3e11e5f839a 259 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 159 178 2.9E-39 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS24270 da8b3e2b400b48da40b9d3e11e5f839a 259 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 2.9E-39 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS24270 da8b3e2b400b48da40b9d3e11e5f839a 259 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 15 250 1.8E-52 T 09-03-2017 TK78_RS24270 da8b3e2b400b48da40b9d3e11e5f839a 259 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 7 190 1.3E-4 T 09-03-2017 TK78_RS24270 da8b3e2b400b48da40b9d3e11e5f839a 259 Gene3D G3DSA:3.40.50.720 1 253 3.8E-76 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS25645 ced20f06bea5e8a4c7871626fdd419d1 274 SUPERFAMILY SSF56784 47 238 1.58E-13 T 09-03-2017 IPR023214 HAD-like domain TK78_RS25645 ced20f06bea5e8a4c7871626fdd419d1 274 SUPERFAMILY SSF56784 10 20 1.58E-13 T 09-03-2017 IPR023214 HAD-like domain TK78_RS25645 ced20f06bea5e8a4c7871626fdd419d1 274 PIRSF PIRSF030802 6 246 6.2E-14 T 09-03-2017 IPR024197 Uncharacterised conserved protein UCP030802 TK78_RS25645 ced20f06bea5e8a4c7871626fdd419d1 274 Gene3D G3DSA:3.40.50.1000 187 235 2.9E-9 T 09-03-2017 IPR023214 HAD-like domain TK78_RS25645 ced20f06bea5e8a4c7871626fdd419d1 274 Gene3D G3DSA:3.40.50.1000 9 111 2.9E-9 T 09-03-2017 IPR023214 HAD-like domain TK78_RS10955 9eb929d5cea7b47579484d3181d7901a 325 SMART SM00382 31 231 9.8E-16 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS10955 9eb929d5cea7b47579484d3181d7901a 325 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 233 297 1.1E-21 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS10955 9eb929d5cea7b47579484d3181d7901a 325 ProSitePatterns PS00211 ABC transporters family signature. 154 168 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS10955 9eb929d5cea7b47579484d3181d7901a 325 SUPERFAMILY SSF52540 31 312 4.76E-69 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10955 9eb929d5cea7b47579484d3181d7901a 325 Gene3D G3DSA:3.40.50.300 2 256 4.3E-75 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10955 9eb929d5cea7b47579484d3181d7901a 325 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 231 317 1.5E-29 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS10955 9eb929d5cea7b47579484d3181d7901a 325 Pfam PF00005 ABC transporter 23 181 6.9E-28 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS18970 6c8ea62775425634d93a974d7cc80ee0 261 SUPERFAMILY SSF53335 16 153 9.6E-6 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS30325 07b1d263822a4bddc5ad429f6b647b56 370 Pfam PF01180 Dihydroorotate dehydrogenase 50 348 1.6E-91 T 09-03-2017 IPR005720 Dihydroorotate dehydrogenase domain GO:0005737|GO:0016627|GO:0055114 TK78_RS30325 07b1d263822a4bddc5ad429f6b647b56 370 SUPERFAMILY SSF51395 1 362 1.01E-99 T 09-03-2017 TK78_RS30325 07b1d263822a4bddc5ad429f6b647b56 370 ProSitePatterns PS00912 Dihydroorotate dehydrogenase signature 2. 300 320 - T 09-03-2017 IPR001295 Dihydroorotate dehydrogenase, conserved site GO:0004152|GO:0006207|GO:0055114 Reactome: R-HSA-500753 TK78_RS30325 07b1d263822a4bddc5ad429f6b647b56 370 TIGRFAM TIGR01036 pyrD_sub2: dihydroorotate dehydrogenase (fumarate) 3 365 1.6E-124 T 09-03-2017 IPR005719 Dihydroorotate dehydrogenase, class 2 GO:0004152|GO:0006207|GO:0016020|GO:0055114 KEGG: 00240+1.3.5.2|MetaCyc: PWY-5686|Reactome: R-HSA-500753 TK78_RS30325 07b1d263822a4bddc5ad429f6b647b56 370 Hamap MF_00225 Dihydroorotate dehydrogenase (quinone) [pyrD]. 1 344 46.406 T 09-03-2017 IPR005719 Dihydroorotate dehydrogenase, class 2 GO:0004152|GO:0006207|GO:0016020|GO:0055114 KEGG: 00240+1.3.5.2|MetaCyc: PWY-5686|Reactome: R-HSA-500753 TK78_RS30325 07b1d263822a4bddc5ad429f6b647b56 370 Gene3D G3DSA:3.20.20.70 1 364 5.0E-126 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS29895 e97a8a867397335ef10bc7d9e561d385 359 SUPERFAMILY SSF52540 2 245 2.6E-78 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29895 e97a8a867397335ef10bc7d9e561d385 359 SUPERFAMILY SSF55021 255 333 6.18E-18 T 09-03-2017 TK78_RS29895 e97a8a867397335ef10bc7d9e561d385 359 ProSitePatterns PS00211 ABC transporters family signature. 147 161 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS29895 e97a8a867397335ef10bc7d9e561d385 359 Gene3D G3DSA:3.30.70.260 250 333 1.7E-22 T 09-03-2017 TK78_RS29895 e97a8a867397335ef10bc7d9e561d385 359 SMART SM00382 30 233 1.4E-9 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS29895 e97a8a867397335ef10bc7d9e561d385 359 Pfam PF09383 NIL domain 259 331 9.6E-18 T 09-03-2017 IPR018449 NIL domain TK78_RS29895 e97a8a867397335ef10bc7d9e561d385 359 Gene3D G3DSA:3.40.50.300 2 246 2.7E-81 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29895 e97a8a867397335ef10bc7d9e561d385 359 Pfam PF00005 ABC transporter 21 175 4.2E-33 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS29895 e97a8a867397335ef10bc7d9e561d385 359 SMART SM00930 257 332 4.7E-20 T 09-03-2017 IPR018449 NIL domain TK78_RS04610 5e469bd379bb405898901c24b02a7e30 549 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 358 374 3.5E-46 T 09-03-2017 TK78_RS04610 5e469bd379bb405898901c24b02a7e30 549 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 322 338 3.5E-46 T 09-03-2017 TK78_RS04610 5e469bd379bb405898901c24b02a7e30 549 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 307 322 3.5E-46 T 09-03-2017 TK78_RS04610 5e469bd379bb405898901c24b02a7e30 549 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 155 170 3.5E-46 T 09-03-2017 TK78_RS04610 5e469bd379bb405898901c24b02a7e30 549 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 8 30 3.5E-46 T 09-03-2017 TK78_RS04610 5e469bd379bb405898901c24b02a7e30 549 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 340 358 3.5E-46 T 09-03-2017 TK78_RS04610 5e469bd379bb405898901c24b02a7e30 549 Gene3D G3DSA:3.50.50.60 4 166 8.9E-53 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS04610 5e469bd379bb405898901c24b02a7e30 549 Gene3D G3DSA:3.50.50.60 305 344 8.9E-53 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS04610 5e469bd379bb405898901c24b02a7e30 549 Pfam PF01494 FAD binding domain 7 372 2.4E-77 T 09-03-2017 IPR002938 FAD-binding domain GO:0071949 TK78_RS04610 5e469bd379bb405898901c24b02a7e30 549 Gene3D G3DSA:3.30.9.10 167 300 1.3E-10 T 09-03-2017 TK78_RS04610 5e469bd379bb405898901c24b02a7e30 549 Gene3D G3DSA:3.30.9.10 355 371 1.3E-10 T 09-03-2017 TK78_RS04610 5e469bd379bb405898901c24b02a7e30 549 SUPERFAMILY SSF51905 7 176 1.3E-59 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS04610 5e469bd379bb405898901c24b02a7e30 549 SUPERFAMILY SSF51905 294 378 1.3E-59 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS16495 4c9f9de1c72e9d2ba8d50ef87f0c8a0a 430 Pfam PF04542 Sigma-70 region 2 11 76 6.8E-12 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16495 4c9f9de1c72e9d2ba8d50ef87f0c8a0a 430 Gene3D G3DSA:1.10.10.10 117 176 1.1E-12 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS16495 4c9f9de1c72e9d2ba8d50ef87f0c8a0a 430 SUPERFAMILY SSF88946 8 88 5.89E-14 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16495 4c9f9de1c72e9d2ba8d50ef87f0c8a0a 430 Pfam PF08281 Sigma-70, region 4 125 174 4.1E-10 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16495 4c9f9de1c72e9d2ba8d50ef87f0c8a0a 430 SUPERFAMILY SSF88659 118 176 9.59E-10 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16495 4c9f9de1c72e9d2ba8d50ef87f0c8a0a 430 Gene3D G3DSA:1.10.1740.10 7 94 5.0E-13 T 09-03-2017 TK78_RS14845 0db1edb7501626c217d270a7e2fa2ea2 805 SMART SM00387 666 801 1.1E-30 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS14845 0db1edb7501626c217d270a7e2fa2ea2 805 SUPERFAMILY SSF55781 358 538 1.18E-30 T 09-03-2017 IPR029016 GAF domain-like TK78_RS14845 0db1edb7501626c217d270a7e2fa2ea2 805 Gene3D G3DSA:3.30.450.40 167 334 5.7E-12 T 09-03-2017 IPR029016 GAF domain-like TK78_RS14845 0db1edb7501626c217d270a7e2fa2ea2 805 SUPERFAMILY SSF55874 614 778 6.16E-29 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS14845 0db1edb7501626c217d270a7e2fa2ea2 805 SUPERFAMILY SSF55785 22 152 6.02E-27 T 09-03-2017 IPR000014 PAS domain TK78_RS14845 0db1edb7501626c217d270a7e2fa2ea2 805 SUPERFAMILY SSF47384 540 622 4.12E-13 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS14845 0db1edb7501626c217d270a7e2fa2ea2 805 SMART SM00388 556 624 2.9E-5 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS14845 0db1edb7501626c217d270a7e2fa2ea2 805 Gene3D G3DSA:3.30.450.20 51 105 1.0E-4 T 09-03-2017 TK78_RS14845 0db1edb7501626c217d270a7e2fa2ea2 805 SUPERFAMILY SSF55781 163 345 3.05E-55 T 09-03-2017 IPR029016 GAF domain-like TK78_RS14845 0db1edb7501626c217d270a7e2fa2ea2 805 Gene3D G3DSA:3.30.565.10 623 798 6.0E-30 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS14845 0db1edb7501626c217d270a7e2fa2ea2 805 SMART SM00065 179 350 1.3E-7 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS14845 0db1edb7501626c217d270a7e2fa2ea2 805 Pfam PF08446 PAS fold 29 96 1.4E-9 T 09-03-2017 IPR013654 PAS fold-2 GO:0006355 TK78_RS14845 0db1edb7501626c217d270a7e2fa2ea2 805 Pfam PF00512 His Kinase A (phospho-acceptor) domain 558 622 2.6E-6 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS14845 0db1edb7501626c217d270a7e2fa2ea2 805 PRINTS PR01033 Phytochrome signature 194 213 5.6E-11 T 09-03-2017 IPR001294 Phytochrome GO:0006355|GO:0009584 TK78_RS14845 0db1edb7501626c217d270a7e2fa2ea2 805 PRINTS PR01033 Phytochrome signature 282 303 5.6E-11 T 09-03-2017 IPR001294 Phytochrome GO:0006355|GO:0009584 TK78_RS14845 0db1edb7501626c217d270a7e2fa2ea2 805 PRINTS PR01033 Phytochrome signature 465 484 5.6E-11 T 09-03-2017 IPR001294 Phytochrome GO:0006355|GO:0009584 TK78_RS14845 0db1edb7501626c217d270a7e2fa2ea2 805 PRINTS PR01033 Phytochrome signature 499 517 5.6E-11 T 09-03-2017 IPR001294 Phytochrome GO:0006355|GO:0009584 TK78_RS14845 0db1edb7501626c217d270a7e2fa2ea2 805 PRINTS PR01033 Phytochrome signature 378 398 5.6E-11 T 09-03-2017 IPR001294 Phytochrome GO:0006355|GO:0009584 TK78_RS14845 0db1edb7501626c217d270a7e2fa2ea2 805 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 667 799 8.2E-20 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS14845 0db1edb7501626c217d270a7e2fa2ea2 805 Pfam PF01590 GAF domain 179 345 1.4E-18 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS14845 0db1edb7501626c217d270a7e2fa2ea2 805 Gene3D G3DSA:1.10.287.130 548 620 2.7E-7 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS14845 0db1edb7501626c217d270a7e2fa2ea2 805 Pfam PF00360 Phytochrome region 360 538 4.6E-25 T 09-03-2017 IPR013515 Phytochrome, central region GO:0006355|GO:0009584|GO:0018298 TK78_RS12905 1c974f14c84f6f5246ad0ae79d1193ee 469 SMART SM01043 97 239 6.0E-33 T 09-03-2017 IPR005158 Bacterial transcriptional activator domain TK78_RS12905 1c974f14c84f6f5246ad0ae79d1193ee 469 Gene3D G3DSA:1.10.10.10 21 92 1.6E-9 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS12905 1c974f14c84f6f5246ad0ae79d1193ee 469 SUPERFAMILY SSF46894 3 90 3.97E-13 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS12905 1c974f14c84f6f5246ad0ae79d1193ee 469 Pfam PF03704 Bacterial transcriptional activator domain 97 239 3.0E-31 T 09-03-2017 IPR005158 Bacterial transcriptional activator domain TK78_RS12905 1c974f14c84f6f5246ad0ae79d1193ee 469 Pfam PF00486 Transcriptional regulatory protein, C terminal 22 89 5.6E-9 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS12905 1c974f14c84f6f5246ad0ae79d1193ee 469 Gene3D G3DSA:1.10.3300.10 266 466 2.6E-22 T 09-03-2017 IPR023286 ABATE domain TK78_RS12905 1c974f14c84f6f5246ad0ae79d1193ee 469 SUPERFAMILY SSF48452 96 257 2.47E-22 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS12905 1c974f14c84f6f5246ad0ae79d1193ee 469 Pfam PF11706 CGNR zinc finger 436 466 1.5E-8 T 09-03-2017 IPR021005 Zinc finger, CGNR TK78_RS12905 1c974f14c84f6f5246ad0ae79d1193ee 469 SMART SM00862 15 90 5.3E-11 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS12905 1c974f14c84f6f5246ad0ae79d1193ee 469 SUPERFAMILY SSF160904 265 466 1.44E-17 T 09-03-2017 TK78_RS23180 c52f783f60b5ee874ab92be79540030e 243 SUPERFAMILY SSF52172 1 173 2.13E-37 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS23180 c52f783f60b5ee874ab92be79540030e 243 SMART SM00862 150 225 1.7E-23 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS23180 c52f783f60b5ee874ab92be79540030e 243 SMART SM00448 2 112 6.6E-34 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS23180 c52f783f60b5ee874ab92be79540030e 243 Pfam PF00486 Transcriptional regulatory protein, C terminal 151 223 3.3E-22 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS23180 c52f783f60b5ee874ab92be79540030e 243 Gene3D G3DSA:3.40.50.2300 1 122 9.8E-36 T 09-03-2017 TK78_RS23180 c52f783f60b5ee874ab92be79540030e 243 Gene3D G3DSA:1.10.10.10 129 228 2.8E-32 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS23180 c52f783f60b5ee874ab92be79540030e 243 Pfam PF00072 Response regulator receiver domain 4 111 3.0E-25 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS33145 2673d41d8662eb8160dbb8a1448f3871 324 Pfam PF02653 Branched-chain amino acid transport system / permease component 56 315 9.7E-41 T 09-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 TK78_RS09650 55d7de3edce7d471e159df18c2e3d7b1 216 Pfam PF00196 Bacterial regulatory proteins, luxR family 155 211 8.0E-19 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS09650 55d7de3edce7d471e159df18c2e3d7b1 216 ProSitePatterns PS00622 LuxR-type HTH domain signature. 171 198 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS09650 55d7de3edce7d471e159df18c2e3d7b1 216 Gene3D G3DSA:3.40.50.2300 1 123 1.4E-35 T 09-03-2017 TK78_RS09650 55d7de3edce7d471e159df18c2e3d7b1 216 SMART SM00421 154 211 2.5E-24 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS09650 55d7de3edce7d471e159df18c2e3d7b1 216 Gene3D G3DSA:1.10.10.10 124 216 3.4E-29 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS09650 55d7de3edce7d471e159df18c2e3d7b1 216 SUPERFAMILY SSF52172 2 132 2.28E-31 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS09650 55d7de3edce7d471e159df18c2e3d7b1 216 SMART SM00448 3 115 2.6E-28 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS09650 55d7de3edce7d471e159df18c2e3d7b1 216 SUPERFAMILY SSF46894 148 216 5.1E-20 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS09650 55d7de3edce7d471e159df18c2e3d7b1 216 Pfam PF00072 Response regulator receiver domain 5 116 1.2E-22 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS09650 55d7de3edce7d471e159df18c2e3d7b1 216 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 187 199 7.6E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS09650 55d7de3edce7d471e159df18c2e3d7b1 216 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 171 187 7.6E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS09650 55d7de3edce7d471e159df18c2e3d7b1 216 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 157 171 7.6E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS18215 8f161bfcef2eed4e6355b100a54c8c49 355 Pfam PF00005 ABC transporter 48 185 1.4E-26 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS18215 8f161bfcef2eed4e6355b100a54c8c49 355 Gene3D G3DSA:3.40.50.300 26 249 5.7E-64 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18215 8f161bfcef2eed4e6355b100a54c8c49 355 SUPERFAMILY SSF52540 24 255 3.72E-60 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18215 8f161bfcef2eed4e6355b100a54c8c49 355 SMART SM00382 56 236 1.3E-9 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS18215 8f161bfcef2eed4e6355b100a54c8c49 355 ProSitePatterns PS00211 ABC transporters family signature. 158 172 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS13820 fa0c71997eb9e9d03db689e09d0f60f8 269 SUPERFAMILY SSF54593 12 187 2.05E-20 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS13820 fa0c71997eb9e9d03db689e09d0f60f8 269 SUPERFAMILY SSF54593 134 264 2.82E-16 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS13820 fa0c71997eb9e9d03db689e09d0f60f8 269 Gene3D G3DSA:3.10.180.10 9 121 1.1E-29 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS13820 fa0c71997eb9e9d03db689e09d0f60f8 269 Gene3D G3DSA:3.10.180.10 134 265 1.1E-30 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS13820 fa0c71997eb9e9d03db689e09d0f60f8 269 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 16 114 1.3E-5 T 09-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain TK78_RS28085 0dd98500689c797ae57934554963bd23 330 Pfam PF00701 Dihydrodipicolinate synthetase family 15 302 1.9E-53 T 09-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 TK78_RS28085 0dd98500689c797ae57934554963bd23 330 SUPERFAMILY SSF51569 14 304 1.67E-62 T 09-03-2017 TK78_RS28085 0dd98500689c797ae57934554963bd23 330 PIRSF PIRSF001365 9 316 3.0E-55 T 09-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 TK78_RS28085 0dd98500689c797ae57934554963bd23 330 Hamap MF_00694 Probable 5-dehydro-4-deoxyglucarate dehydratase. 8 308 46.468 T 09-03-2017 IPR017655 5-dehydro-4-deoxyglucarate dehydratase GO:0016052|GO:0047448 KEGG: 00053+4.2.1.41|MetaCyc: PWY-6486|MetaCyc: PWY-6497|MetaCyc: PWY-6499|MetaCyc: PWY-6501 TK78_RS28085 0dd98500689c797ae57934554963bd23 330 Gene3D G3DSA:3.20.20.70 14 309 7.0E-73 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS28085 0dd98500689c797ae57934554963bd23 330 SMART SM01130 12 306 4.1E-67 T 09-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 TK78_RS05320 df6f7d43a5db67eee761467da8e5b746 580 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 383 529 2.3E-40 T 09-03-2017 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 TK78_RS05320 df6f7d43a5db67eee761467da8e5b746 580 Gene3D G3DSA:3.40.50.1220 186 342 6.1E-40 T 09-03-2017 IPR029035 DHS-like NAD/FAD-binding domain TK78_RS05320 df6f7d43a5db67eee761467da8e5b746 580 SUPERFAMILY SSF52467 183 346 1.46E-41 T 09-03-2017 IPR029035 DHS-like NAD/FAD-binding domain TK78_RS05320 df6f7d43a5db67eee761467da8e5b746 580 SUPERFAMILY SSF52518 4 172 2.72E-40 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS05320 df6f7d43a5db67eee761467da8e5b746 580 Pfam PF00205 Thiamine pyrophosphate enzyme, central domain 192 320 5.0E-30 T 09-03-2017 IPR012000 Thiamine pyrophosphate enzyme, central domain GO:0000287|GO:0030976 TK78_RS05320 df6f7d43a5db67eee761467da8e5b746 580 Gene3D G3DSA:3.40.50.970 2 176 1.0E-49 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS05320 df6f7d43a5db67eee761467da8e5b746 580 Gene3D G3DSA:3.40.50.970 356 552 7.7E-57 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS05320 df6f7d43a5db67eee761467da8e5b746 580 SUPERFAMILY SSF52518 360 545 9.26E-59 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS05320 df6f7d43a5db67eee761467da8e5b746 580 Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain 5 171 5.1E-41 T 09-03-2017 IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain GO:0030976 TK78_RS11800 a21aec9ef4e8b339a35fc1460a1a923e 218 Gene3D G3DSA:1.20.1250.20 164 191 6.0E-13 T 09-03-2017 TK78_RS11800 a21aec9ef4e8b339a35fc1460a1a923e 218 Gene3D G3DSA:1.20.1250.20 3 114 6.0E-13 T 09-03-2017 TK78_RS11800 a21aec9ef4e8b339a35fc1460a1a923e 218 SUPERFAMILY SSF103473 163 189 1.11E-13 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS11800 a21aec9ef4e8b339a35fc1460a1a923e 218 SUPERFAMILY SSF103473 3 113 1.11E-13 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS02070 f13f5fe62d1cb8b57b5a2b8155f2d05a 257 Pfam PF01609 Transposase DDE domain 102 253 1.7E-12 T 09-03-2017 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 TK78_RS22480 941e798f6de3f9d216d6db37d53ea4fb 214 SUPERFAMILY SSF46785 7 76 6.92E-16 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS22480 941e798f6de3f9d216d6db37d53ea4fb 214 Pfam PF09339 IclR helix-turn-helix domain 8 58 1.1E-14 T 09-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 TK78_RS22480 941e798f6de3f9d216d6db37d53ea4fb 214 SUPERFAMILY SSF55781 67 213 8.34E-19 T 09-03-2017 IPR029016 GAF domain-like TK78_RS22480 941e798f6de3f9d216d6db37d53ea4fb 214 Gene3D G3DSA:3.30.450.40 80 150 2.4E-13 T 09-03-2017 IPR029016 GAF domain-like TK78_RS22480 941e798f6de3f9d216d6db37d53ea4fb 214 SMART SM00346 6 93 7.8E-16 T 09-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 TK78_RS22480 941e798f6de3f9d216d6db37d53ea4fb 214 Gene3D G3DSA:3.30.450.40 151 213 4.0E-6 T 09-03-2017 IPR029016 GAF domain-like TK78_RS22480 941e798f6de3f9d216d6db37d53ea4fb 214 Gene3D G3DSA:1.10.10.10 5 76 5.9E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS26935 9c669b5cfbec43536d6944ade2c421aa 159 PIRSF PIRSF002560 1 157 1.4E-64 T 09-03-2017 IPR002024 Bacterioferritin GO:0006826|GO:0006879|GO:0008199 TK78_RS26935 9c669b5cfbec43536d6944ade2c421aa 159 Gene3D G3DSA:1.20.1260.10 1 156 1.7E-53 T 09-03-2017 IPR012347 Ferritin-related TK78_RS26935 9c669b5cfbec43536d6944ade2c421aa 159 TIGRFAM TIGR00754 bfr: bacterioferritin 1 156 6.9E-64 T 09-03-2017 IPR002024 Bacterioferritin GO:0006826|GO:0006879|GO:0008199 TK78_RS26935 9c669b5cfbec43536d6944ade2c421aa 159 Pfam PF00210 Ferritin-like domain 9 143 4.1E-32 T 09-03-2017 IPR008331 Ferritin/DPS protein domain GO:0006879|GO:0008199 TK78_RS26935 9c669b5cfbec43536d6944ade2c421aa 159 ProSitePatterns PS00549 Bacterioferritin signature. 1 19 - T 09-03-2017 IPR002024 Bacterioferritin GO:0006826|GO:0006879|GO:0008199 TK78_RS26935 9c669b5cfbec43536d6944ade2c421aa 159 PRINTS PR00601 Bacterioferritin signature 23 43 2.4E-55 T 09-03-2017 IPR002024 Bacterioferritin GO:0006826|GO:0006879|GO:0008199 TK78_RS26935 9c669b5cfbec43536d6944ade2c421aa 159 PRINTS PR00601 Bacterioferritin signature 44 64 2.4E-55 T 09-03-2017 IPR002024 Bacterioferritin GO:0006826|GO:0006879|GO:0008199 TK78_RS26935 9c669b5cfbec43536d6944ade2c421aa 159 PRINTS PR00601 Bacterioferritin signature 86 106 2.4E-55 T 09-03-2017 IPR002024 Bacterioferritin GO:0006826|GO:0006879|GO:0008199 TK78_RS26935 9c669b5cfbec43536d6944ade2c421aa 159 PRINTS PR00601 Bacterioferritin signature 107 127 2.4E-55 T 09-03-2017 IPR002024 Bacterioferritin GO:0006826|GO:0006879|GO:0008199 TK78_RS26935 9c669b5cfbec43536d6944ade2c421aa 159 PRINTS PR00601 Bacterioferritin signature 3 22 2.4E-55 T 09-03-2017 IPR002024 Bacterioferritin GO:0006826|GO:0006879|GO:0008199 TK78_RS26935 9c669b5cfbec43536d6944ade2c421aa 159 PRINTS PR00601 Bacterioferritin signature 128 149 2.4E-55 T 09-03-2017 IPR002024 Bacterioferritin GO:0006826|GO:0006879|GO:0008199 TK78_RS26935 9c669b5cfbec43536d6944ade2c421aa 159 PRINTS PR00601 Bacterioferritin signature 65 85 2.4E-55 T 09-03-2017 IPR002024 Bacterioferritin GO:0006826|GO:0006879|GO:0008199 TK78_RS26935 9c669b5cfbec43536d6944ade2c421aa 159 SUPERFAMILY SSF47240 1 155 5.91E-46 T 09-03-2017 IPR009078 Ferritin-like superfamily TK78_RS18120 8d80ec4e578b5553b7eb571c6e901904 983 Gene3D G3DSA:3.90.1200.10 657 694 2.3E-9 T 09-03-2017 TK78_RS18120 8d80ec4e578b5553b7eb571c6e901904 983 Gene3D G3DSA:3.90.1200.10 818 899 2.3E-9 T 09-03-2017 TK78_RS18120 8d80ec4e578b5553b7eb571c6e901904 983 SUPERFAMILY SSF56112 813 896 5.1E-9 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS18120 8d80ec4e578b5553b7eb571c6e901904 983 Pfam PF01636 Phosphotransferase enzyme family 735 869 7.5E-8 T 09-03-2017 IPR002575 Aminoglycoside phosphotransferase TK78_RS05315 8b137d47e3f0651e2d7e1753082cdfe8 1037 SUPERFAMILY SSF88688 518 616 3.92E-25 T 09-03-2017 IPR028995 Glycoside hydrolase families 57/38, central domain TK78_RS05315 8b137d47e3f0651e2d7e1753082cdfe8 1037 Gene3D G3DSA:3.20.110.10 202 521 4.5E-89 T 09-03-2017 IPR027291 Glycoside hydrolase 38/57, N-terminal domain TK78_RS05315 8b137d47e3f0651e2d7e1753082cdfe8 1037 SMART SM00872 519 598 2.2E-35 T 09-03-2017 IPR015341 Glycoside hydrolase family 38, central domain GO:0004553|GO:0008270 TK78_RS05315 8b137d47e3f0651e2d7e1753082cdfe8 1037 Gene3D G3DSA:1.20.1270.50 522 618 2.9E-22 T 09-03-2017 IPR015341 Glycoside hydrolase family 38, central domain GO:0004553|GO:0008270 TK78_RS05315 8b137d47e3f0651e2d7e1753082cdfe8 1037 Pfam PF01074 Glycosyl hydrolases family 38 N-terminal domain 254 508 5.9E-87 T 09-03-2017 IPR000602 Glycoside hydrolase family 38, N-terminal domain GO:0004559|GO:0005975 TK78_RS05315 8b137d47e3f0651e2d7e1753082cdfe8 1037 SUPERFAMILY SSF74650 621 1035 5.96E-71 T 09-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 TK78_RS05315 8b137d47e3f0651e2d7e1753082cdfe8 1037 Pfam PF07748 Glycosyl hydrolases family 38 C-terminal domain 622 1033 3.5E-68 T 09-03-2017 IPR011682 Glycosyl hydrolase family 38, C-terminal GO:0006013|GO:0015923 TK78_RS05315 8b137d47e3f0651e2d7e1753082cdfe8 1037 Pfam PF09261 Alpha mannosidase middle domain 519 596 3.6E-27 T 09-03-2017 IPR015341 Glycoside hydrolase family 38, central domain GO:0004553|GO:0008270 TK78_RS05315 8b137d47e3f0651e2d7e1753082cdfe8 1037 SUPERFAMILY SSF88713 250 517 2.89E-74 T 09-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 TK78_RS11930 1e50cbf7a61981f83367a9d2c773cda7 501 SUPERFAMILY SSF55785 32 140 1.21E-20 T 09-03-2017 IPR000014 PAS domain TK78_RS11930 1e50cbf7a61981f83367a9d2c773cda7 501 Pfam PF00989 PAS fold 25 120 6.4E-9 T 09-03-2017 IPR013767 PAS fold GO:0006355 TK78_RS11930 1e50cbf7a61981f83367a9d2c773cda7 501 SUPERFAMILY SSF55785 129 247 9.77E-16 T 09-03-2017 IPR000014 PAS domain TK78_RS11930 1e50cbf7a61981f83367a9d2c773cda7 501 SMART SM00091 19 86 2.2E-5 T 09-03-2017 IPR000014 PAS domain TK78_RS11930 1e50cbf7a61981f83367a9d2c773cda7 501 SMART SM00091 141 206 0.21 T 09-03-2017 IPR000014 PAS domain TK78_RS11930 1e50cbf7a61981f83367a9d2c773cda7 501 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 28 140 1.5E-14 T 09-03-2017 IPR000014 PAS domain TK78_RS11930 1e50cbf7a61981f83367a9d2c773cda7 501 SMART SM00331 286 493 5.0E-36 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS11930 1e50cbf7a61981f83367a9d2c773cda7 501 SUPERFAMILY SSF81606 301 492 3.4E-10 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS11930 1e50cbf7a61981f83367a9d2c773cda7 501 Gene3D G3DSA:3.30.450.20 24 129 4.6E-20 T 09-03-2017 TK78_RS11930 1e50cbf7a61981f83367a9d2c773cda7 501 Pfam PF08448 PAS fold 148 259 2.8E-22 T 09-03-2017 IPR013656 PAS fold-4 TK78_RS11930 1e50cbf7a61981f83367a9d2c773cda7 501 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 313 492 4.9E-46 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS11930 1e50cbf7a61981f83367a9d2c773cda7 501 Gene3D G3DSA:3.30.450.20 136 257 1.2E-18 T 09-03-2017 TK78_RS23705 d2f4e3529326dc5d5cc0ce1054b23c9f 610 SUPERFAMILY SSF51445 36 429 1.58E-107 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS23705 d2f4e3529326dc5d5cc0ce1054b23c9f 610 Gene3D G3DSA:3.20.20.300 60 417 9.5E-113 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS23705 d2f4e3529326dc5d5cc0ce1054b23c9f 610 ProSitePatterns PS00775 Glycosyl hydrolases family 3 active site. 314 331 - T 09-03-2017 IPR019800 Glycoside hydrolase, family 3, active site GO:0004553|GO:0005975 TK78_RS23705 d2f4e3529326dc5d5cc0ce1054b23c9f 610 SUPERFAMILY SSF52279 432 610 1.19E-15 T 09-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 TK78_RS23705 d2f4e3529326dc5d5cc0ce1054b23c9f 610 PRINTS PR00133 Glycosyl hydrolase family 3 signature 314 332 6.4E-5 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS23705 d2f4e3529326dc5d5cc0ce1054b23c9f 610 PRINTS PR00133 Glycosyl hydrolase family 3 signature 237 253 6.4E-5 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS23705 d2f4e3529326dc5d5cc0ce1054b23c9f 610 PRINTS PR00133 Glycosyl hydrolase family 3 signature 133 149 6.4E-5 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS23705 d2f4e3529326dc5d5cc0ce1054b23c9f 610 Pfam PF00933 Glycosyl hydrolase family 3 N terminal domain 54 393 6.9E-116 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS23705 d2f4e3529326dc5d5cc0ce1054b23c9f 610 Gene3D G3DSA:3.40.50.1700 418 609 8.0E-18 T 09-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 TK78_RS23705 d2f4e3529326dc5d5cc0ce1054b23c9f 610 Pfam PF01915 Glycosyl hydrolase family 3 C-terminal domain 432 610 1.1E-14 T 09-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 TK78_RS04090 5c35a034979a2fc71976a02c1b3a09e5 504 Gene3D G3DSA:3.40.50.10330 267 320 3.2E-4 T 09-03-2017 IPR017438 Inorganic polyphosphate/ATP-NAD kinase, domain 1 GO:0003951|GO:0008152 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 TK78_RS04090 5c35a034979a2fc71976a02c1b3a09e5 504 SMART SM00046 216 329 4.4E-7 T 09-03-2017 IPR001206 Diacylglycerol kinase, catalytic domain GO:0016301 TK78_RS04090 5c35a034979a2fc71976a02c1b3a09e5 504 SUPERFAMILY SSF111331 214 501 1.7E-45 T 09-03-2017 IPR016064 NAD kinase/diacylglycerol kinase-like domain TK78_RS04090 5c35a034979a2fc71976a02c1b3a09e5 504 SMART SM00014 80 189 3.3E-17 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS04090 5c35a034979a2fc71976a02c1b3a09e5 504 Pfam PF00781 Diacylglycerol kinase catalytic domain 217 328 1.3E-15 T 09-03-2017 IPR001206 Diacylglycerol kinase, catalytic domain GO:0016301 TK78_RS04090 5c35a034979a2fc71976a02c1b3a09e5 504 Pfam PF01569 PAP2 superfamily 85 193 2.1E-17 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS04090 5c35a034979a2fc71976a02c1b3a09e5 504 SUPERFAMILY SSF48317 14 200 1.57E-36 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS04090 5c35a034979a2fc71976a02c1b3a09e5 504 Gene3D G3DSA:1.20.144.10 11 197 6.9E-31 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS26530 0cb52f2bc688262e8a3f8d9c11dd7573 188 Pfam PF13302 Acetyltransferase (GNAT) domain 9 150 4.5E-18 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS26530 0cb52f2bc688262e8a3f8d9c11dd7573 188 SUPERFAMILY SSF55729 5 173 8.65E-37 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS26530 0cb52f2bc688262e8a3f8d9c11dd7573 188 Gene3D G3DSA:3.40.630.30 5 179 2.4E-39 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS10485 6680ce13d7ad699cd7e1a9abcebfd33f 139 Pfam PF01475 Ferric uptake regulator family 11 127 4.5E-25 T 09-03-2017 IPR002481 Ferric-uptake regulator GO:0003700|GO:0006355 TK78_RS10485 6680ce13d7ad699cd7e1a9abcebfd33f 139 Gene3D G3DSA:1.10.10.10 2 82 3.8E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS10485 6680ce13d7ad699cd7e1a9abcebfd33f 139 SUPERFAMILY SSF46785 3 134 3.63E-33 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS01535 550e57801c8a77895cfafee9f302e58a 372 Gene3D G3DSA:1.10.540.10 15 129 1.7E-13 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS01535 550e57801c8a77895cfafee9f302e58a 372 SUPERFAMILY SSF47203 231 365 1.77E-34 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS01535 550e57801c8a77895cfafee9f302e58a 372 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 225 365 1.2E-26 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS01535 550e57801c8a77895cfafee9f302e58a 372 SUPERFAMILY SSF56645 11 208 1.24E-17 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS01535 550e57801c8a77895cfafee9f302e58a 372 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 16 116 2.1E-12 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS01535 550e57801c8a77895cfafee9f302e58a 372 Gene3D G3DSA:1.20.140.10 225 365 5.5E-34 T 09-03-2017 TK78_RS07930 f01b689ea19a1a38bc8266c5eee25009 471 Gene3D G3DSA:3.30.9.10 136 188 1.8E-5 T 09-03-2017 TK78_RS07930 f01b689ea19a1a38bc8266c5eee25009 471 Gene3D G3DSA:3.30.9.10 266 366 1.8E-5 T 09-03-2017 TK78_RS07930 f01b689ea19a1a38bc8266c5eee25009 471 SUPERFAMILY SSF51905 17 135 1.41E-39 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS07930 f01b689ea19a1a38bc8266c5eee25009 471 SUPERFAMILY SSF51905 191 321 1.41E-39 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS07930 f01b689ea19a1a38bc8266c5eee25009 471 Pfam PF01266 FAD dependent oxidoreductase 42 404 2.5E-47 T 09-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 TK78_RS07930 f01b689ea19a1a38bc8266c5eee25009 471 Gene3D G3DSA:3.50.50.60 32 132 3.5E-34 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS07930 f01b689ea19a1a38bc8266c5eee25009 471 Gene3D G3DSA:3.50.50.60 189 265 3.5E-34 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS07930 f01b689ea19a1a38bc8266c5eee25009 471 Gene3D G3DSA:3.50.50.60 369 421 3.5E-34 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS26455 11cd799cc430e3babd02b81932d4d8b5 222 SMART SM00862 146 220 4.4E-23 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS26455 11cd799cc430e3babd02b81932d4d8b5 222 Pfam PF00486 Transcriptional regulatory protein, C terminal 149 219 2.2E-23 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS26455 11cd799cc430e3babd02b81932d4d8b5 222 Gene3D G3DSA:1.10.10.10 128 220 2.6E-30 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS26455 11cd799cc430e3babd02b81932d4d8b5 222 SUPERFAMILY SSF46894 127 220 1.52E-27 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS14590 0e1c87ae0792ad18cea3915e9384e758 198 TIGRFAM TIGR02258 2_5_ligase: 2'-5' RNA ligase 13 182 7.0E-31 T 09-03-2017 IPR004175 RNA 2',3'-cyclic phosphodiesterase GO:0004113|GO:0008664 TK78_RS14590 0e1c87ae0792ad18cea3915e9384e758 198 SUPERFAMILY SSF55144 13 198 1.34E-37 T 09-03-2017 IPR009097 RNA ligase/cyclic nucleotide phosphodiesterase TK78_RS14590 0e1c87ae0792ad18cea3915e9384e758 198 Gene3D G3DSA:3.90.1140.10 13 197 2.6E-52 T 09-03-2017 IPR009097 RNA ligase/cyclic nucleotide phosphodiesterase TK78_RS14590 0e1c87ae0792ad18cea3915e9384e758 198 Hamap MF_01940 RNA 2',3'-cyclic phosphodiesterase [thpR]. 12 196 22.009 T 09-03-2017 IPR004175 RNA 2',3'-cyclic phosphodiesterase GO:0004113|GO:0008664 TK78_RS14590 0e1c87ae0792ad18cea3915e9384e758 198 Pfam PF13563 2'-5' RNA ligase superfamily 47 174 5.7E-15 T 09-03-2017 TK78_RS06255 03e663cd321b4f61ed0c50dc5b3f05b2 209 SUPERFAMILY SSF51197 31 204 1.32E-40 T 09-03-2017 TK78_RS06255 03e663cd321b4f61ed0c50dc5b3f05b2 209 Gene3D G3DSA:2.60.120.590 86 204 2.1E-17 T 09-03-2017 IPR027450 Alpha-ketoglutarate-dependent dioxygenase AlkB-like TK78_RS06255 03e663cd321b4f61ed0c50dc5b3f05b2 209 Pfam PF13532 2OG-Fe(II) oxygenase superfamily 96 196 4.2E-14 T 09-03-2017 IPR027450 Alpha-ketoglutarate-dependent dioxygenase AlkB-like TK78_RS00385 be8ecc37381a3afeaea97b504b104eeb 101 Pfam PF14542 GCN5-related N-acetyl-transferase 13 90 2.3E-25 T 09-03-2017 IPR031165 Yjdj-type Gcn5-related N-acetyltransferase TK78_RS00385 be8ecc37381a3afeaea97b504b104eeb 101 SUPERFAMILY SSF55729 4 91 2.66E-26 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS00385 be8ecc37381a3afeaea97b504b104eeb 101 Gene3D G3DSA:3.40.630.30 2 93 1.2E-28 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS33030 710046cfadad551876f3af85ccd16877 264 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 134 142 1.6E-7 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33030 710046cfadad551876f3af85ccd16877 264 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 81 92 1.6E-7 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33030 710046cfadad551876f3af85ccd16877 264 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 154 173 1.6E-7 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33030 710046cfadad551876f3af85ccd16877 264 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 14 258 5.0E-44 T 09-03-2017 TK78_RS33030 710046cfadad551876f3af85ccd16877 264 Gene3D G3DSA:3.40.50.720 4 259 5.8E-68 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS33030 710046cfadad551876f3af85ccd16877 264 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 128 144 1.3E-27 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33030 710046cfadad551876f3af85ccd16877 264 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 222 242 1.3E-27 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33030 710046cfadad551876f3af85ccd16877 264 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 154 173 1.3E-27 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33030 710046cfadad551876f3af85ccd16877 264 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 175 192 1.3E-27 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33030 710046cfadad551876f3af85ccd16877 264 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 81 92 1.3E-27 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33030 710046cfadad551876f3af85ccd16877 264 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 9 26 1.3E-27 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33030 710046cfadad551876f3af85ccd16877 264 SUPERFAMILY SSF51735 3 259 3.38E-65 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS33030 710046cfadad551876f3af85ccd16877 264 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 141 169 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS10295 8b25b0b66a3c351aafbe29ab0a405226 432 Pfam PF13416 Bacterial extracellular solute-binding protein 60 352 9.7E-27 T 09-03-2017 TK78_RS10295 8b25b0b66a3c351aafbe29ab0a405226 432 SUPERFAMILY SSF53850 35 425 1.68E-59 T 09-03-2017 TK78_RS10295 8b25b0b66a3c351aafbe29ab0a405226 432 Gene3D G3DSA:3.40.190.10 170 352 3.6E-26 T 09-03-2017 TK78_RS10295 8b25b0b66a3c351aafbe29ab0a405226 432 Gene3D G3DSA:3.40.190.10 37 169 1.0E-19 T 09-03-2017 TK78_RS26600 fdc7024a4de60160efe8c74d215e44df 299 Pfam PF01370 NAD dependent epimerase/dehydratase family 6 215 1.8E-14 T 09-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 TK78_RS26600 fdc7024a4de60160efe8c74d215e44df 299 TIGRFAM TIGR01777 yfcH: TIGR01777 family protein 6 294 1.5E-98 T 09-03-2017 IPR010099 Epimerase family protein SDR39U1 TK78_RS26600 fdc7024a4de60160efe8c74d215e44df 299 SUPERFAMILY SSF51735 3 255 5.64E-39 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS26600 fdc7024a4de60160efe8c74d215e44df 299 Gene3D G3DSA:3.40.50.720 3 239 1.5E-24 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS26600 fdc7024a4de60160efe8c74d215e44df 299 Pfam PF08338 Domain of unknown function (DUF1731) 251 296 5.7E-19 T 09-03-2017 IPR013549 Domain of unknown function DUF1731 TK78_RS03145 cb9d541330a6838edb6082896aae07d5 356 Gene3D G3DSA:1.10.600.10 43 355 7.5E-83 T 09-03-2017 IPR008949 Isoprenoid synthase domain TK78_RS03145 cb9d541330a6838edb6082896aae07d5 356 ProSitePatterns PS00723 Polyprenyl synthases signature 1. 103 117 - T 09-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 TK78_RS03145 cb9d541330a6838edb6082896aae07d5 356 Pfam PF00348 Polyprenyl synthetase 65 289 8.8E-53 T 09-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 TK78_RS03145 cb9d541330a6838edb6082896aae07d5 356 SUPERFAMILY SSF48576 37 355 3.36E-76 T 09-03-2017 IPR008949 Isoprenoid synthase domain TK78_RS16440 519cb5532dcf595f38fcd0234378c8d1 444 Gene3D G3DSA:3.90.1530.10 42 97 1.8E-35 T 09-03-2017 TK78_RS16440 519cb5532dcf595f38fcd0234378c8d1 444 Gene3D G3DSA:3.90.1530.10 134 215 1.8E-35 T 09-03-2017 TK78_RS16440 519cb5532dcf595f38fcd0234378c8d1 444 SUPERFAMILY SSF110849 45 97 3.5E-54 T 09-03-2017 IPR003115 ParB/Sulfiredoxin TK78_RS16440 519cb5532dcf595f38fcd0234378c8d1 444 SUPERFAMILY SSF110849 134 288 3.5E-54 T 09-03-2017 IPR003115 ParB/Sulfiredoxin TK78_RS16440 519cb5532dcf595f38fcd0234378c8d1 444 Pfam PF08857 Putative ParB-like nuclease 50 255 2.5E-51 T 09-03-2017 IPR014956 Putative ParB-like nuclease TK78_RS17390 c19b039746f3cec391d0ecd23d3ca17c 191 Hamap MF_00630 UPF0232 protein . 1 177 30.121 T 09-03-2017 IPR023007 Uncharacterised protein family UPF0232, actinobacteria TK78_RS17390 c19b039746f3cec391d0ecd23d3ca17c 191 Pfam PF05258 Protein of unknown function (DUF721) 75 165 4.8E-24 T 09-03-2017 IPR007922 Protein of unknown function DUF721/UPF0232 TK78_RS00810 751dc5272196d8847adc4f2c4645687b 338 SMART SM00116 285 333 0.096 T 09-03-2017 IPR000644 CBS domain TK78_RS00810 751dc5272196d8847adc4f2c4645687b 338 SMART SM00116 225 273 19.0 T 09-03-2017 IPR000644 CBS domain TK78_RS00810 751dc5272196d8847adc4f2c4645687b 338 Pfam PF01595 Domain of unknown function DUF21 10 197 2.0E-36 T 09-03-2017 IPR002550 Domain of unknown function DUF21 TK78_RS00810 751dc5272196d8847adc4f2c4645687b 338 SUPERFAMILY SSF54631 205 334 8.1E-22 T 09-03-2017 TK78_RS00810 751dc5272196d8847adc4f2c4645687b 338 Gene3D G3DSA:3.10.580.10 220 332 2.0E-10 T 09-03-2017 TK78_RS00810 751dc5272196d8847adc4f2c4645687b 338 Pfam PF00571 CBS domain 284 333 8.0E-5 T 09-03-2017 IPR000644 CBS domain TK78_RS06715 e1e4ed15ad50db2839e46300726e7538 557 Pfam PF08245 Mur ligase middle domain 41 219 7.1E-6 T 09-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 TK78_RS06715 e1e4ed15ad50db2839e46300726e7538 557 Gene3D G3DSA:3.40.1190.10 37 239 5.6E-9 T 09-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 TK78_RS06715 e1e4ed15ad50db2839e46300726e7538 557 TIGRFAM TIGR04012 poly_gGlu_PgsB: poly-gamma-glutamate synthase PgsB 7 387 8.0E-113 T 09-03-2017 IPR008337 Capsule biosynthesis protein CapB GO:0016020|GO:0045227 TK78_RS06715 e1e4ed15ad50db2839e46300726e7538 557 SUPERFAMILY SSF53623 35 222 5.15E-10 T 09-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 TK78_RS06715 e1e4ed15ad50db2839e46300726e7538 557 PRINTS PR01758 Capsule biosynthesis protein CapB signature 143 158 7.3E-32 T 09-03-2017 IPR008337 Capsule biosynthesis protein CapB GO:0016020|GO:0045227 TK78_RS06715 e1e4ed15ad50db2839e46300726e7538 557 PRINTS PR01758 Capsule biosynthesis protein CapB signature 366 382 7.3E-32 T 09-03-2017 IPR008337 Capsule biosynthesis protein CapB GO:0016020|GO:0045227 TK78_RS06715 e1e4ed15ad50db2839e46300726e7538 557 PRINTS PR01758 Capsule biosynthesis protein CapB signature 114 129 7.3E-32 T 09-03-2017 IPR008337 Capsule biosynthesis protein CapB GO:0016020|GO:0045227 TK78_RS06715 e1e4ed15ad50db2839e46300726e7538 557 PRINTS PR01758 Capsule biosynthesis protein CapB signature 297 312 7.3E-32 T 09-03-2017 IPR008337 Capsule biosynthesis protein CapB GO:0016020|GO:0045227 TK78_RS06715 e1e4ed15ad50db2839e46300726e7538 557 PRINTS PR01758 Capsule biosynthesis protein CapB signature 61 78 7.3E-32 T 09-03-2017 IPR008337 Capsule biosynthesis protein CapB GO:0016020|GO:0045227 TK78_RS06715 e1e4ed15ad50db2839e46300726e7538 557 PRINTS PR01758 Capsule biosynthesis protein CapB signature 199 216 7.3E-32 T 09-03-2017 IPR008337 Capsule biosynthesis protein CapB GO:0016020|GO:0045227 TK78_RS06715 e1e4ed15ad50db2839e46300726e7538 557 PRINTS PR01758 Capsule biosynthesis protein CapB signature 262 279 7.3E-32 T 09-03-2017 IPR008337 Capsule biosynthesis protein CapB GO:0016020|GO:0045227 TK78_RS06715 e1e4ed15ad50db2839e46300726e7538 557 PRINTS PR01758 Capsule biosynthesis protein CapB signature 38 54 7.3E-32 T 09-03-2017 IPR008337 Capsule biosynthesis protein CapB GO:0016020|GO:0045227 TK78_RS23455 a0257e865bd7310e717c2c86b6a1010c 388 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 8 120 3.8E-37 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS23455 a0257e865bd7310e717c2c86b6a1010c 388 Gene3D G3DSA:2.40.110.10 123 227 1.0E-35 T 09-03-2017 TK78_RS23455 a0257e865bd7310e717c2c86b6a1010c 388 Gene3D G3DSA:1.20.140.10 228 384 1.5E-64 T 09-03-2017 TK78_RS23455 a0257e865bd7310e717c2c86b6a1010c 388 SUPERFAMILY SSF47203 234 384 1.77E-49 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS23455 a0257e865bd7310e717c2c86b6a1010c 388 PIRSF PIRSF016578 4 386 2.2E-12 T 09-03-2017 TK78_RS23455 a0257e865bd7310e717c2c86b6a1010c 388 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 236 384 3.0E-47 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS23455 a0257e865bd7310e717c2c86b6a1010c 388 ProSitePatterns PS00072 Acyl-CoA dehydrogenases signature 1. 126 138 - T 09-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 TK78_RS23455 a0257e865bd7310e717c2c86b6a1010c 388 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 124 224 3.5E-21 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS23455 a0257e865bd7310e717c2c86b6a1010c 388 SUPERFAMILY SSF56645 3 249 1.57E-79 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS23455 a0257e865bd7310e717c2c86b6a1010c 388 Gene3D G3DSA:1.10.540.10 3 120 1.0E-41 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS23455 a0257e865bd7310e717c2c86b6a1010c 388 ProSitePatterns PS00073 Acyl-CoA dehydrogenases signature 2. 343 362 - T 09-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 TK78_RS06500 5de1ef98b99edfec28656cdd009c6308 345 Pfam PF01032 FecCD transport family 33 340 3.8E-81 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS06500 5de1ef98b99edfec28656cdd009c6308 345 SUPERFAMILY SSF81345 20 340 1.7E-70 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS06500 5de1ef98b99edfec28656cdd009c6308 345 Gene3D G3DSA:1.10.3470.10 18 342 7.1E-87 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS05130 c595d99a800b20611064caed5ea58356 311 Pfam PF02735 Ku70/Ku80 beta-barrel domain 12 179 1.3E-30 T 09-03-2017 IPR006164 Ku70/Ku80 beta-barrel domain GO:0003677|GO:0006303 Reactome: R-HSA-164843|Reactome: R-HSA-1834949|Reactome: R-HSA-3270619|Reactome: R-HSA-5693571 TK78_RS05130 c595d99a800b20611064caed5ea58356 311 TIGRFAM TIGR02772 Ku_bact: Ku protein 3 257 5.5E-80 T 09-03-2017 IPR009187 Non-homologous end joining protein Ku, prokaryotic type TK78_RS05130 c595d99a800b20611064caed5ea58356 311 PIRSF PIRSF006493 1 311 5.0E-76 T 09-03-2017 IPR009187 Non-homologous end joining protein Ku, prokaryotic type TK78_RS05130 c595d99a800b20611064caed5ea58356 311 Gene3D G3DSA:2.40.290.10 5 147 1.1E-11 T 09-03-2017 IPR016194 SPOC-like, C-terminal domain TK78_RS05130 c595d99a800b20611064caed5ea58356 311 SUPERFAMILY SSF100939 1 257 2.16E-46 T 09-03-2017 IPR016194 SPOC-like, C-terminal domain TK78_RS05130 c595d99a800b20611064caed5ea58356 311 SMART SM00559 53 182 5.5E-38 T 09-03-2017 IPR006164 Ku70/Ku80 beta-barrel domain GO:0003677|GO:0006303 Reactome: R-HSA-164843|Reactome: R-HSA-1834949|Reactome: R-HSA-3270619|Reactome: R-HSA-5693571 TK78_RS05130 c595d99a800b20611064caed5ea58356 311 Hamap MF_01875 Non-homologous end joining protein Ku [ku]. 2 254 30.496 T 09-03-2017 IPR009187 Non-homologous end joining protein Ku, prokaryotic type TK78_RS34360 0aa357df87aedb3a3801fc3d23dbcad4 262 SUPERFAMILY SSF54593 15 127 3.62E-17 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS34360 0aa357df87aedb3a3801fc3d23dbcad4 262 Gene3D G3DSA:3.10.180.10 14 124 4.7E-28 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS34360 0aa357df87aedb3a3801fc3d23dbcad4 262 Gene3D G3DSA:3.10.180.10 140 256 2.3E-16 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS34360 0aa357df87aedb3a3801fc3d23dbcad4 262 SUPERFAMILY SSF54593 142 261 9.26E-13 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS19095 f655d0f6a590db216b42cfe55361bcda 508 SUPERFAMILY SSF53850 55 498 4.03E-81 T 09-03-2017 TK78_RS19095 f655d0f6a590db216b42cfe55361bcda 508 Gene3D G3DSA:3.10.105.10 283 476 3.9E-27 T 09-03-2017 TK78_RS19095 f655d0f6a590db216b42cfe55361bcda 508 PIRSF PIRSF002741 16 500 7.5E-48 T 09-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 TK78_RS19095 f655d0f6a590db216b42cfe55361bcda 508 Gene3D G3DSA:3.40.190.10 140 282 1.2E-26 T 09-03-2017 TK78_RS19095 f655d0f6a590db216b42cfe55361bcda 508 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 82 426 3.5E-49 T 09-03-2017 IPR000914 Solute-binding protein family 5 domain TK78_RS33650 7fc815f43911f05ccbb0bcbaf4e7fc74 374 SUPERFAMILY SSF51735 161 345 1.28E-77 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS33650 7fc815f43911f05ccbb0bcbaf4e7fc74 374 SUPERFAMILY SSF51735 1 124 1.28E-77 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS33650 7fc815f43911f05ccbb0bcbaf4e7fc74 374 Gene3D G3DSA:3.40.50.720 1 131 1.6E-38 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS33650 7fc815f43911f05ccbb0bcbaf4e7fc74 374 Gene3D G3DSA:3.40.50.720 167 211 1.6E-38 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS33650 7fc815f43911f05ccbb0bcbaf4e7fc74 374 Gene3D G3DSA:3.90.25.10 212 345 1.1E-28 T 09-03-2017 TK78_RS33650 7fc815f43911f05ccbb0bcbaf4e7fc74 374 PRINTS PR01713 Nucleotide sugar epimerase signature 274 289 3.5E-5 T 09-03-2017 IPR008089 Nucleotide sugar epimerase GO:0005975|GO:0016857 Reactome: R-HSA-5609977|Reactome: R-HSA-70370 TK78_RS33650 7fc815f43911f05ccbb0bcbaf4e7fc74 374 PRINTS PR01713 Nucleotide sugar epimerase signature 313 330 3.5E-5 T 09-03-2017 IPR008089 Nucleotide sugar epimerase GO:0005975|GO:0016857 Reactome: R-HSA-5609977|Reactome: R-HSA-70370 TK78_RS33650 7fc815f43911f05ccbb0bcbaf4e7fc74 374 PRINTS PR01713 Nucleotide sugar epimerase signature 247 262 3.5E-5 T 09-03-2017 IPR008089 Nucleotide sugar epimerase GO:0005975|GO:0016857 Reactome: R-HSA-5609977|Reactome: R-HSA-70370 TK78_RS33650 7fc815f43911f05ccbb0bcbaf4e7fc74 374 Pfam PF01370 NAD dependent epimerase/dehydratase family 3 271 1.2E-40 T 09-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 TK78_RS31540 452a969818cd9b1324a692bb57ba60f2 425 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 243 280 - T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS31540 452a969818cd9b1324a692bb57ba60f2 425 TIGRFAM TIGR00508 bioA: adenosylmethionine-8-amino-7-oxononanoate transaminase 9 421 4.1E-165 T 09-03-2017 IPR005815 Adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA GO:0004015|GO:0009102 KEGG: 00780+2.6.1.62 TK78_RS31540 452a969818cd9b1324a692bb57ba60f2 425 Hamap MF_00834 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [bioA]. 1 425 47.899 T 09-03-2017 IPR005815 Adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA GO:0004015|GO:0009102 KEGG: 00780+2.6.1.62 TK78_RS31540 452a969818cd9b1324a692bb57ba60f2 425 Pfam PF00202 Aminotransferase class-III 20 418 1.0E-112 T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS31540 452a969818cd9b1324a692bb57ba60f2 425 Gene3D G3DSA:3.90.1150.10 333 423 4.7E-49 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS31540 452a969818cd9b1324a692bb57ba60f2 425 Gene3D G3DSA:3.90.1150.10 1 61 4.7E-49 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS31540 452a969818cd9b1324a692bb57ba60f2 425 SUPERFAMILY SSF53383 3 423 1.13E-114 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS31540 452a969818cd9b1324a692bb57ba60f2 425 Gene3D G3DSA:3.40.640.10 62 328 5.5E-84 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS28130 b0134094d7406b43668c263b1e5a8c6a 256 SUPERFAMILY SSF55781 78 252 6.54E-48 T 09-03-2017 IPR029016 GAF domain-like TK78_RS28130 b0134094d7406b43668c263b1e5a8c6a 256 Gene3D G3DSA:3.30.450.40 86 251 5.2E-53 T 09-03-2017 IPR029016 GAF domain-like TK78_RS28130 b0134094d7406b43668c263b1e5a8c6a 256 SUPERFAMILY SSF46785 11 83 1.66E-13 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS28130 b0134094d7406b43668c263b1e5a8c6a 256 Pfam PF01614 Bacterial transcriptional regulator 133 250 2.5E-28 T 09-03-2017 IPR014757 Transcription regulator IclR, C-terminal TK78_RS28130 b0134094d7406b43668c263b1e5a8c6a 256 Gene3D G3DSA:1.10.10.10 10 74 1.9E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS28130 b0134094d7406b43668c263b1e5a8c6a 256 Pfam PF09339 IclR helix-turn-helix domain 13 63 8.7E-14 T 09-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 TK78_RS28130 b0134094d7406b43668c263b1e5a8c6a 256 SMART SM00346 11 101 3.2E-20 T 09-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 TK78_RS01740 91ee67aa15f1079ce746e5ff1d30bdf7 78 TIGRFAM TIGR00009 L28: ribosomal protein bL28 1 58 4.2E-27 T 09-03-2017 IPR001383 Ribosomal protein L28 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS01740 91ee67aa15f1079ce746e5ff1d30bdf7 78 Gene3D G3DSA:2.30.170.40 2 78 2.6E-32 T 09-03-2017 TK78_RS01740 91ee67aa15f1079ce746e5ff1d30bdf7 78 Hamap MF_00373 50S ribosomal protein L28 [rpmB]. 1 71 20.436 T 09-03-2017 IPR001383 Ribosomal protein L28 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS01740 91ee67aa15f1079ce746e5ff1d30bdf7 78 SUPERFAMILY SSF143800 2 77 2.94E-26 T 09-03-2017 TK78_RS01740 91ee67aa15f1079ce746e5ff1d30bdf7 78 Pfam PF00830 Ribosomal L28 family 4 60 7.2E-25 T 09-03-2017 IPR026569 Ribosomal protein L28/L24 GO:0003735 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS04165 dab3492086fcb3d47f56fcd8f2feca0e 303 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 3 62 9.4E-22 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS04165 dab3492086fcb3d47f56fcd8f2feca0e 303 Gene3D G3DSA:3.40.190.10 90 176 3.5E-16 T 09-03-2017 TK78_RS04165 dab3492086fcb3d47f56fcd8f2feca0e 303 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 2.6E-8 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS04165 dab3492086fcb3d47f56fcd8f2feca0e 303 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 2.6E-8 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS04165 dab3492086fcb3d47f56fcd8f2feca0e 303 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 2.6E-8 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS04165 dab3492086fcb3d47f56fcd8f2feca0e 303 SUPERFAMILY SSF46785 1 85 3.25E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS04165 dab3492086fcb3d47f56fcd8f2feca0e 303 Pfam PF03466 LysR substrate binding domain 87 292 5.9E-43 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS04165 dab3492086fcb3d47f56fcd8f2feca0e 303 Gene3D G3DSA:3.40.190.10 177 261 7.5E-22 T 09-03-2017 TK78_RS04165 dab3492086fcb3d47f56fcd8f2feca0e 303 Gene3D G3DSA:1.10.10.10 1 85 7.1E-28 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS04165 dab3492086fcb3d47f56fcd8f2feca0e 303 SUPERFAMILY SSF53850 89 292 8.96E-38 T 09-03-2017 TK78_RS17040 9d8cf1af1b259f465a25987ee55f3c23 590 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 473 492 1.9E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS17040 9d8cf1af1b259f465a25987ee55f3c23 590 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 399 410 1.9E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS17040 9d8cf1af1b259f465a25987ee55f3c23 590 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 453 461 1.9E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS17040 9d8cf1af1b259f465a25987ee55f3c23 590 SUPERFAMILY SSF51735 319 584 9.81E-68 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS17040 9d8cf1af1b259f465a25987ee55f3c23 590 Pfam PF00561 alpha/beta hydrolase fold 29 142 6.5E-18 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS17040 9d8cf1af1b259f465a25987ee55f3c23 590 Gene3D G3DSA:3.40.50.1820 6 294 2.7E-47 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS17040 9d8cf1af1b259f465a25987ee55f3c23 590 SUPERFAMILY SSF53474 5 295 1.37E-42 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS17040 9d8cf1af1b259f465a25987ee55f3c23 590 Pfam PF00106 short chain dehydrogenase 324 514 1.3E-55 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS17040 9d8cf1af1b259f465a25987ee55f3c23 590 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 447 463 4.3E-26 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS17040 9d8cf1af1b259f465a25987ee55f3c23 590 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 494 511 4.3E-26 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS17040 9d8cf1af1b259f465a25987ee55f3c23 590 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 324 341 4.3E-26 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS17040 9d8cf1af1b259f465a25987ee55f3c23 590 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 399 410 4.3E-26 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS17040 9d8cf1af1b259f465a25987ee55f3c23 590 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 473 492 4.3E-26 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS17040 9d8cf1af1b259f465a25987ee55f3c23 590 Gene3D G3DSA:3.40.50.720 322 557 2.4E-68 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS17040 9d8cf1af1b259f465a25987ee55f3c23 590 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 460 488 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS00195 ec81ae7b2b0d48f45159bbf69c1145cd 109 Pfam PF01980 Uncharacterised protein family UPF0066 4 81 4.0E-13 T 09-03-2017 IPR023370 TsaA-like domain TK78_RS00195 ec81ae7b2b0d48f45159bbf69c1145cd 109 Gene3D G3DSA:2.40.30.70 3 98 8.7E-18 T 09-03-2017 IPR023370 TsaA-like domain TK78_RS00195 ec81ae7b2b0d48f45159bbf69c1145cd 109 SUPERFAMILY SSF118196 2 105 5.89E-23 T 09-03-2017 IPR023370 TsaA-like domain TK78_RS33340 005f697474ad5a312410ac6d9e631e69 259 SMART SM00382 31 216 5.4E-17 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS33340 005f697474ad5a312410ac6d9e631e69 259 SUPERFAMILY SSF52540 7 229 1.33E-61 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33340 005f697474ad5a312410ac6d9e631e69 259 ProSitePatterns PS00211 ABC transporters family signature. 143 157 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS33340 005f697474ad5a312410ac6d9e631e69 259 Pfam PF00005 ABC transporter 22 171 8.1E-32 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS33340 005f697474ad5a312410ac6d9e631e69 259 Gene3D G3DSA:3.40.50.300 7 236 6.9E-63 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01490 d15bf3c6bf6250926b174182496539aa 335 Gene3D G3DSA:3.40.50.300 7 270 1.0E-59 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01490 d15bf3c6bf6250926b174182496539aa 335 SMART SM00382 44 241 7.7E-16 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS01490 d15bf3c6bf6250926b174182496539aa 335 Pfam PF00005 ABC transporter 37 192 2.8E-20 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS01490 d15bf3c6bf6250926b174182496539aa 335 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 243 304 1.2E-11 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS01490 d15bf3c6bf6250926b174182496539aa 335 SUPERFAMILY SSF52540 12 256 1.04E-50 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01490 d15bf3c6bf6250926b174182496539aa 335 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 241 314 4.1E-18 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS34190 39cebcee90f246009b89aa46a9e5ba08 54 TIGRFAM TIGR01023 rpmG_bact: ribosomal protein bL33 1 54 2.7E-22 T 09-03-2017 IPR001705 Ribosomal protein L33 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS34190 39cebcee90f246009b89aa46a9e5ba08 54 ProSitePatterns PS00582 Ribosomal protein L33 signature. 22 41 - T 09-03-2017 IPR018264 Ribosomal protein L33, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS34190 39cebcee90f246009b89aa46a9e5ba08 54 SUPERFAMILY SSF57829 5 54 2.75E-16 T 09-03-2017 IPR011332 Zinc-binding ribosomal protein GO:0006412 TK78_RS34190 39cebcee90f246009b89aa46a9e5ba08 54 Pfam PF00471 Ribosomal protein L33 9 53 3.3E-17 T 09-03-2017 IPR001705 Ribosomal protein L33 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS34190 39cebcee90f246009b89aa46a9e5ba08 54 Hamap MF_00294 50S ribosomal protein L33 [rpmG]. 2 54 14.696 T 09-03-2017 IPR001705 Ribosomal protein L33 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS06045 bffdbfa0fc6afdb045e57c8eae99cb07 904 SUPERFAMILY SSF52016 641 901 2.75E-85 T 09-03-2017 IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel TK78_RS06045 bffdbfa0fc6afdb045e57c8eae99cb07 904 Gene3D G3DSA:3.40.1060.10 241 358 5.5E-36 T 09-03-2017 IPR015932 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2 GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS06045 bffdbfa0fc6afdb045e57c8eae99cb07 904 Pfam PF00694 Aconitase C-terminal domain 702 831 1.6E-43 T 09-03-2017 IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel domain GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS06045 bffdbfa0fc6afdb045e57c8eae99cb07 904 TIGRFAM TIGR01341 aconitase_1: aconitate hydratase 1 26 901 0.0 T 09-03-2017 IPR006249 Aconitase/Iron-responsive element-binding protein 2 KEGG: 00020+4.2.1.3|KEGG: 00630+4.2.1.3|KEGG: 00720+4.2.1.3 TK78_RS06045 bffdbfa0fc6afdb045e57c8eae99cb07 904 ProSitePatterns PS01244 Aconitase family signature 2. 503 516 - T 09-03-2017 IPR018136 Aconitase family, 4Fe-4S cluster binding site KEGG: 00290+4.2.1.33 TK78_RS06045 bffdbfa0fc6afdb045e57c8eae99cb07 904 ProSitePatterns PS00450 Aconitase family signature 1. 437 453 - T 09-03-2017 IPR018136 Aconitase family, 4Fe-4S cluster binding site KEGG: 00290+4.2.1.33 TK78_RS06045 bffdbfa0fc6afdb045e57c8eae99cb07 904 SUPERFAMILY SSF53732 4 637 1.29E-220 T 09-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS06045 bffdbfa0fc6afdb045e57c8eae99cb07 904 Gene3D G3DSA:3.20.19.10 647 901 3.8E-77 T 09-03-2017 IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel TK78_RS06045 bffdbfa0fc6afdb045e57c8eae99cb07 904 Gene3D G3DSA:3.30.499.10 28 240 9.3E-79 T 09-03-2017 IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS06045 bffdbfa0fc6afdb045e57c8eae99cb07 904 PRINTS PR00415 Aconitase family signature 270 283 3.4E-42 T 09-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS06045 bffdbfa0fc6afdb045e57c8eae99cb07 904 PRINTS PR00415 Aconitase family signature 141 154 3.4E-42 T 09-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS06045 bffdbfa0fc6afdb045e57c8eae99cb07 904 PRINTS PR00415 Aconitase family signature 284 297 3.4E-42 T 09-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS06045 bffdbfa0fc6afdb045e57c8eae99cb07 904 PRINTS PR00415 Aconitase family signature 363 377 3.4E-42 T 09-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS06045 bffdbfa0fc6afdb045e57c8eae99cb07 904 PRINTS PR00415 Aconitase family signature 165 173 3.4E-42 T 09-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS06045 bffdbfa0fc6afdb045e57c8eae99cb07 904 PRINTS PR00415 Aconitase family signature 194 207 3.4E-42 T 09-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS06045 bffdbfa0fc6afdb045e57c8eae99cb07 904 PRINTS PR00415 Aconitase family signature 503 516 3.4E-42 T 09-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS06045 bffdbfa0fc6afdb045e57c8eae99cb07 904 PRINTS PR00415 Aconitase family signature 441 452 3.4E-42 T 09-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS06045 bffdbfa0fc6afdb045e57c8eae99cb07 904 PRINTS PR00415 Aconitase family signature 208 223 3.4E-42 T 09-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS06045 bffdbfa0fc6afdb045e57c8eae99cb07 904 Gene3D G3DSA:3.30.499.10 429 585 2.7E-64 T 09-03-2017 IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS06045 bffdbfa0fc6afdb045e57c8eae99cb07 904 Gene3D G3DSA:3.30.499.10 360 384 2.7E-64 T 09-03-2017 IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS06045 bffdbfa0fc6afdb045e57c8eae99cb07 904 Pfam PF00330 Aconitase family (aconitate hydratase) 64 572 1.1E-182 T 09-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS33185 574ccbccbbc10003565c5b9ca82355da 105 Pfam PF00805 Pentapeptide repeats (8 copies) 67 94 1.6E-4 T 09-03-2017 IPR001646 Pentapeptide repeat TK78_RS33185 574ccbccbbc10003565c5b9ca82355da 105 Pfam PF00805 Pentapeptide repeats (8 copies) 16 53 1.8E-10 T 09-03-2017 IPR001646 Pentapeptide repeat TK78_RS33185 574ccbccbbc10003565c5b9ca82355da 105 SUPERFAMILY SSF141571 16 94 1.83E-20 T 09-03-2017 TK78_RS01390 0cdb685d3ca338ca6c2a8671e85502ce 844 SMART SM00091 165 233 150.0 T 09-03-2017 IPR000014 PAS domain TK78_RS01390 0cdb685d3ca338ca6c2a8671e85502ce 844 SMART SM00091 283 349 1.1E-7 T 09-03-2017 IPR000014 PAS domain TK78_RS01390 0cdb685d3ca338ca6c2a8671e85502ce 844 Pfam PF08448 PAS fold 290 373 2.4E-9 T 09-03-2017 IPR013656 PAS fold-4 TK78_RS01390 0cdb685d3ca338ca6c2a8671e85502ce 844 Gene3D G3DSA:3.30.450.40 427 573 1.3E-13 T 09-03-2017 IPR029016 GAF domain-like TK78_RS01390 0cdb685d3ca338ca6c2a8671e85502ce 844 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 619 803 1.5E-49 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS01390 0cdb685d3ca338ca6c2a8671e85502ce 844 Gene3D G3DSA:3.30.450.40 5 146 4.2E-6 T 09-03-2017 IPR029016 GAF domain-like TK78_RS01390 0cdb685d3ca338ca6c2a8671e85502ce 844 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 290 333 1.3E-6 T 09-03-2017 IPR000014 PAS domain TK78_RS01390 0cdb685d3ca338ca6c2a8671e85502ce 844 SMART SM00331 590 804 9.7E-34 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS01390 0cdb685d3ca338ca6c2a8671e85502ce 844 SUPERFAMILY SSF55781 8 145 4.8E-7 T 09-03-2017 IPR029016 GAF domain-like TK78_RS01390 0cdb685d3ca338ca6c2a8671e85502ce 844 SUPERFAMILY SSF55785 290 375 1.39E-13 T 09-03-2017 IPR000014 PAS domain TK78_RS01390 0cdb685d3ca338ca6c2a8671e85502ce 844 Pfam PF13185 GAF domain 9 145 8.0E-7 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS01390 0cdb685d3ca338ca6c2a8671e85502ce 844 Pfam PF13185 GAF domain 426 563 4.3E-13 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS01390 0cdb685d3ca338ca6c2a8671e85502ce 844 Gene3D G3DSA:3.30.450.20 176 266 1.2E-5 T 09-03-2017 TK78_RS01390 0cdb685d3ca338ca6c2a8671e85502ce 844 SUPERFAMILY SSF55785 176 267 1.38E-6 T 09-03-2017 IPR000014 PAS domain TK78_RS01390 0cdb685d3ca338ca6c2a8671e85502ce 844 SMART SM00065 426 572 2.9E-5 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS01390 0cdb685d3ca338ca6c2a8671e85502ce 844 Gene3D G3DSA:3.30.450.20 289 382 7.1E-15 T 09-03-2017 TK78_RS01390 0cdb685d3ca338ca6c2a8671e85502ce 844 SUPERFAMILY SSF55781 432 572 3.27E-16 T 09-03-2017 IPR029016 GAF domain-like TK78_RS01390 0cdb685d3ca338ca6c2a8671e85502ce 844 SUPERFAMILY SSF81606 607 802 6.28E-6 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS29370 3bdb84fb287ff5901f1faad7964ef3e6 344 SUPERFAMILY SSF47413 11 71 2.46E-16 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS29370 3bdb84fb287ff5901f1faad7964ef3e6 344 Pfam PF13377 Periplasmic binding protein-like domain 179 336 7.9E-34 T 09-03-2017 TK78_RS29370 3bdb84fb287ff5901f1faad7964ef3e6 344 SMART SM00354 11 83 8.5E-25 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS29370 3bdb84fb287ff5901f1faad7964ef3e6 344 Gene3D G3DSA:3.40.50.2300 65 179 3.6E-24 T 09-03-2017 TK78_RS29370 3bdb84fb287ff5901f1faad7964ef3e6 344 SUPERFAMILY SSF53822 73 341 6.09E-51 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS29370 3bdb84fb287ff5901f1faad7964ef3e6 344 Gene3D G3DSA:1.10.260.40 12 64 5.5E-24 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS29370 3bdb84fb287ff5901f1faad7964ef3e6 344 Pfam PF00356 Bacterial regulatory proteins, lacI family 15 60 6.1E-16 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS29370 3bdb84fb287ff5901f1faad7964ef3e6 344 Gene3D G3DSA:3.40.50.2300 180 338 5.4E-44 T 09-03-2017 TK78_RS34270 7b1f4d2af7cb525b711203a2a235ca9d 234 Gene3D G3DSA:2.10.109.10 169 222 1.2E-40 T 09-03-2017 IPR028360 Peptidase S24/S26, beta-ribbon domain TK78_RS34270 7b1f4d2af7cb525b711203a2a235ca9d 234 Gene3D G3DSA:2.10.109.10 34 127 1.2E-40 T 09-03-2017 IPR028360 Peptidase S24/S26, beta-ribbon domain TK78_RS34270 7b1f4d2af7cb525b711203a2a235ca9d 234 ProSitePatterns PS00761 Signal peptidases I signature 3. 174 187 - T 09-03-2017 IPR019758 Peptidase S26A, signal peptidase I, conserved site GO:0008236|GO:0016021 TK78_RS34270 7b1f4d2af7cb525b711203a2a235ca9d 234 SUPERFAMILY SSF51306 112 221 3.14E-47 T 09-03-2017 IPR015927 Peptidase S24/S26A/S26B/S26C TK78_RS34270 7b1f4d2af7cb525b711203a2a235ca9d 234 SUPERFAMILY SSF51306 37 85 3.14E-47 T 09-03-2017 IPR015927 Peptidase S24/S26A/S26B/S26C TK78_RS34270 7b1f4d2af7cb525b711203a2a235ca9d 234 Pfam PF00717 Peptidase S24-like 45 87 4.0E-11 T 09-03-2017 IPR019759 Peptidase S24/S26A/S26B TK78_RS34270 7b1f4d2af7cb525b711203a2a235ca9d 234 TIGRFAM TIGR02227 sigpep_I_bact: signal peptidase I 24 215 1.5E-42 T 09-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 TK78_RS34270 7b1f4d2af7cb525b711203a2a235ca9d 234 Pfam PF10502 Signal peptidase, peptidase S26 94 211 2.6E-9 T 09-03-2017 IPR019533 Peptidase S26 TK78_RS34270 7b1f4d2af7cb525b711203a2a235ca9d 234 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 38 54 1.2E-20 T 09-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 TK78_RS34270 7b1f4d2af7cb525b711203a2a235ca9d 234 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 169 188 1.2E-20 T 09-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 TK78_RS34270 7b1f4d2af7cb525b711203a2a235ca9d 234 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 117 129 1.2E-20 T 09-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 TK78_RS09395 3fe128e53bc5f2d88516eabef2698de0 693 Pfam PF13500 AAA domain 3 205 6.8E-19 T 09-03-2017 TK78_RS09395 3fe128e53bc5f2d88516eabef2698de0 693 Pfam PF07085 DRTGG domain 210 319 5.1E-20 T 09-03-2017 IPR010766 DRTGG KEGG: 00430+2.3.1.8|KEGG: 00620+2.3.1.8|KEGG: 00640+2.3.1.8|KEGG: 00680+2.3.1.8|KEGG: 00720+2.3.1.8|MetaCyc: PWY-1281|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497|MetaCyc: PWY-6637 TK78_RS09395 3fe128e53bc5f2d88516eabef2698de0 693 SUPERFAMILY SSF52540 4 211 2.39E-10 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09395 3fe128e53bc5f2d88516eabef2698de0 693 PIRSF PIRSF006107 1 691 1.3E-177 T 09-03-2017 IPR016475 Phosphate acetyltransferase, bacteria GO:0008959 KEGG: 00430+2.3.1.8|KEGG: 00620+2.3.1.8|KEGG: 00640+2.3.1.8|KEGG: 00680+2.3.1.8|KEGG: 00720+2.3.1.8|MetaCyc: PWY-1281|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497|MetaCyc: PWY-6637 TK78_RS09395 3fe128e53bc5f2d88516eabef2698de0 693 Gene3D G3DSA:3.40.50.10750 501 659 8.6E-67 T 09-03-2017 TK78_RS09395 3fe128e53bc5f2d88516eabef2698de0 693 SUPERFAMILY SSF53659 365 686 9.87E-96 T 09-03-2017 TK78_RS09395 3fe128e53bc5f2d88516eabef2698de0 693 Pfam PF01515 Phosphate acetyl/butaryl transferase 366 683 1.1E-125 T 09-03-2017 IPR002505 Phosphate acetyl/butaryl transferase GO:0008152|GO:0016746 KEGG: 00430+2.3.1.8|KEGG: 00620+2.3.1.8|KEGG: 00640+2.3.1.8|KEGG: 00680+2.3.1.8|KEGG: 00720+2.3.1.8|MetaCyc: PWY-1281|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497|MetaCyc: PWY-6637 TK78_RS09395 3fe128e53bc5f2d88516eabef2698de0 693 TIGRFAM TIGR00651 pta: phosphate acetyltransferase 382 683 2.4E-119 T 09-03-2017 IPR004614 Phosphate acetyltransferase GO:0016407 KEGG: 00430+2.3.1.8|KEGG: 00620+2.3.1.8|KEGG: 00640+2.3.1.8|KEGG: 00680+2.3.1.8|KEGG: 00720+2.3.1.8|MetaCyc: PWY-1281|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497|MetaCyc: PWY-6637 TK78_RS09395 3fe128e53bc5f2d88516eabef2698de0 693 SUPERFAMILY SSF75138 204 322 9.81E-18 T 09-03-2017 IPR028979 HPr(Ser) kinase/phosphorylase, N-terminal domain-like TK78_RS09395 3fe128e53bc5f2d88516eabef2698de0 693 Gene3D G3DSA:3.40.1390.20 205 342 1.1E-24 T 09-03-2017 IPR028979 HPr(Ser) kinase/phosphorylase, N-terminal domain-like TK78_RS09395 3fe128e53bc5f2d88516eabef2698de0 693 Gene3D G3DSA:3.40.50.300 3 204 5.4E-11 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS19240 9e3909944d6297530bf098c60ee14ac7 553 SUPERFAMILY SSF52777 186 436 1.0E-41 T 09-03-2017 TK78_RS19240 9e3909944d6297530bf098c60ee14ac7 553 Pfam PF00668 Condensation domain 2 298 4.4E-49 T 09-03-2017 IPR001242 Condensation domain TK78_RS19240 9e3909944d6297530bf098c60ee14ac7 553 SUPERFAMILY SSF52777 1 199 3.89E-35 T 09-03-2017 TK78_RS19240 9e3909944d6297530bf098c60ee14ac7 553 Gene3D G3DSA:1.10.1200.10 487 547 1.5E-6 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS19240 9e3909944d6297530bf098c60ee14ac7 553 SUPERFAMILY SSF47336 487 544 7.46E-7 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS19240 9e3909944d6297530bf098c60ee14ac7 553 Pfam PF13745 HxxPF-repeated domain 320 418 9.7E-14 T 09-03-2017 TK78_RS06530 88502aefd43a41e61ea7ed7a87a05a71 282 SMART SM00530 23 78 6.3E-9 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS06530 88502aefd43a41e61ea7ed7a87a05a71 282 Pfam PF13560 Helix-turn-helix domain 19 79 5.6E-10 T 09-03-2017 TK78_RS06530 88502aefd43a41e61ea7ed7a87a05a71 282 Gene3D G3DSA:1.10.260.40 13 76 2.1E-12 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS06530 88502aefd43a41e61ea7ed7a87a05a71 282 SUPERFAMILY SSF47413 11 77 6.48E-14 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS23360 ec63612d7cbf9118585a53362ee5c0d4 201 Pfam PF00929 Exonuclease 6 168 1.0E-23 T 09-03-2017 IPR013520 Exonuclease, RNase T/DNA polymerase III TK78_RS23360 ec63612d7cbf9118585a53362ee5c0d4 201 SMART SM00479 4 178 2.2E-23 T 09-03-2017 IPR013520 Exonuclease, RNase T/DNA polymerase III TK78_RS23360 ec63612d7cbf9118585a53362ee5c0d4 201 Hamap MF_00045 Oligoribonuclease [orn]. 1 179 37.532 T 09-03-2017 IPR022894 Oligoribonuclease GO:0016788 TK78_RS23360 ec63612d7cbf9118585a53362ee5c0d4 201 SUPERFAMILY SSF53098 3 177 1.52E-40 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS23360 ec63612d7cbf9118585a53362ee5c0d4 201 Gene3D G3DSA:3.30.420.10 1 177 1.3E-66 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS08080 54ceb2484695135227e87d9a47220834 278 SUPERFAMILY SSF46934 3 55 8.93E-16 T 09-03-2017 IPR009060 UBA-like GO:0005515 TK78_RS08080 54ceb2484695135227e87d9a47220834 278 SUPERFAMILY SSF54713 151 277 2.09E-37 T 09-03-2017 IPR014039 Translation elongation factor EFTs/EF1B, dimerisation GO:0003746|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 TK78_RS08080 54ceb2484695135227e87d9a47220834 278 ProSitePatterns PS01126 Elongation factor Ts signature 1. 12 27 - T 09-03-2017 IPR018101 Translation elongation factor Ts, conserved site GO:0003746|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 TK78_RS08080 54ceb2484695135227e87d9a47220834 278 Hamap MF_00050 Elongation factor Ts [tsf]. 1 278 63.202 T 09-03-2017 IPR001816 Translation elongation factor EFTs/EF1B GO:0003746|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 TK78_RS08080 54ceb2484695135227e87d9a47220834 278 SUPERFAMILY SSF54713 57 147 4.32E-19 T 09-03-2017 IPR014039 Translation elongation factor EFTs/EF1B, dimerisation GO:0003746|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 TK78_RS08080 54ceb2484695135227e87d9a47220834 278 ProSitePatterns PS01127 Elongation factor Ts signature 2. 77 87 - T 09-03-2017 IPR018101 Translation elongation factor Ts, conserved site GO:0003746|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 TK78_RS08080 54ceb2484695135227e87d9a47220834 278 Gene3D G3DSA:1.10.286.20 198 241 1.4E-18 T 09-03-2017 TK78_RS08080 54ceb2484695135227e87d9a47220834 278 Gene3D G3DSA:1.10.8.10 3 55 6.0E-24 T 09-03-2017 TK78_RS08080 54ceb2484695135227e87d9a47220834 278 Pfam PF00889 Elongation factor TS 73 277 3.4E-61 T 09-03-2017 IPR014039 Translation elongation factor EFTs/EF1B, dimerisation GO:0003746|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 TK78_RS08080 54ceb2484695135227e87d9a47220834 278 Gene3D G3DSA:3.30.479.20 57 150 3.9E-21 T 09-03-2017 IPR014039 Translation elongation factor EFTs/EF1B, dimerisation GO:0003746|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 TK78_RS08080 54ceb2484695135227e87d9a47220834 278 Gene3D G3DSA:3.30.479.20 152 193 1.9E-22 T 09-03-2017 IPR014039 Translation elongation factor EFTs/EF1B, dimerisation GO:0003746|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 TK78_RS08080 54ceb2484695135227e87d9a47220834 278 Gene3D G3DSA:3.30.479.20 242 277 1.9E-22 T 09-03-2017 IPR014039 Translation elongation factor EFTs/EF1B, dimerisation GO:0003746|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 TK78_RS08080 54ceb2484695135227e87d9a47220834 278 TIGRFAM TIGR00116 tsf: translation elongation factor Ts 1 277 1.7E-73 T 09-03-2017 IPR001816 Translation elongation factor EFTs/EF1B GO:0003746|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 TK78_RS33120 1f195fb0e437f787b39db6457eccb33c 549 SUPERFAMILY SSF53474 192 246 5.58E-23 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS33120 1f195fb0e437f787b39db6457eccb33c 549 SUPERFAMILY SSF53474 365 494 5.58E-23 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS33120 1f195fb0e437f787b39db6457eccb33c 549 SUPERFAMILY SSF53474 94 151 5.58E-23 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS33120 1f195fb0e437f787b39db6457eccb33c 549 Pfam PF08386 TAP-like protein 419 517 8.5E-21 T 09-03-2017 IPR013595 Peptidase S33 tripeptidyl aminopeptidase-like, C-terminal TK78_RS33120 1f195fb0e437f787b39db6457eccb33c 549 Pfam PF00561 alpha/beta hydrolase fold 101 274 1.5E-25 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS33120 1f195fb0e437f787b39db6457eccb33c 549 Gene3D G3DSA:3.40.50.1820 387 505 1.7E-59 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS33120 1f195fb0e437f787b39db6457eccb33c 549 Gene3D G3DSA:3.40.50.1820 65 150 1.7E-59 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS33120 1f195fb0e437f787b39db6457eccb33c 549 Gene3D G3DSA:3.40.50.1820 190 314 1.7E-59 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04065 71f2c0831bbb6cea1e083e6fe60fa56a 350 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 13 23 5.9E-6 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS04065 71f2c0831bbb6cea1e083e6fe60fa56a 350 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 23 33 5.9E-6 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS04065 71f2c0831bbb6cea1e083e6fe60fa56a 350 SUPERFAMILY SSF47413 11 69 2.79E-16 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS04065 71f2c0831bbb6cea1e083e6fe60fa56a 350 SMART SM00354 11 81 1.3E-22 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS04065 71f2c0831bbb6cea1e083e6fe60fa56a 350 ProSitePatterns PS00356 LacI-type HTH domain signature. 14 32 - T 09-03-2017 TK78_RS04065 71f2c0831bbb6cea1e083e6fe60fa56a 350 Gene3D G3DSA:1.10.260.40 12 67 2.4E-20 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS04065 71f2c0831bbb6cea1e083e6fe60fa56a 350 SUPERFAMILY SSF53822 93 349 1.01E-62 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS04065 71f2c0831bbb6cea1e083e6fe60fa56a 350 Pfam PF13377 Periplasmic binding protein-like domain 191 349 1.1E-36 T 09-03-2017 TK78_RS04065 71f2c0831bbb6cea1e083e6fe60fa56a 350 Pfam PF00356 Bacterial regulatory proteins, lacI family 13 58 1.9E-15 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS04065 71f2c0831bbb6cea1e083e6fe60fa56a 350 Gene3D G3DSA:3.40.50.2300 68 188 9.7E-22 T 09-03-2017 TK78_RS04065 71f2c0831bbb6cea1e083e6fe60fa56a 350 Gene3D G3DSA:3.40.50.2300 189 349 2.9E-56 T 09-03-2017 TK78_RS17700 7b8b458fe4529c574912eaf20e4cf624 531 Pfam PF00069 Protein kinase domain 30 284 4.2E-47 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS17700 7b8b458fe4529c574912eaf20e4cf624 531 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 153 165 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS17700 7b8b458fe4529c574912eaf20e4cf624 531 SUPERFAMILY SSF56112 28 294 2.43E-73 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS17700 7b8b458fe4529c574912eaf20e4cf624 531 Gene3D G3DSA:1.10.510.10 120 293 2.2E-49 T 09-03-2017 TK78_RS17700 7b8b458fe4529c574912eaf20e4cf624 531 Gene3D G3DSA:1.10.510.10 397 460 2.2E-49 T 09-03-2017 TK78_RS17700 7b8b458fe4529c574912eaf20e4cf624 531 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 36 59 - T 09-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 TK78_RS17700 7b8b458fe4529c574912eaf20e4cf624 531 Gene3D G3DSA:3.30.200.20 26 113 2.2E-25 T 09-03-2017 TK78_RS17700 7b8b458fe4529c574912eaf20e4cf624 531 SMART SM00220 30 292 8.1E-58 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS04360 a38ba52ca73ae7cc7eb120bf33144bfe 342 SUPERFAMILY SSF63829 50 332 3.92E-47 T 09-03-2017 TK78_RS04360 a38ba52ca73ae7cc7eb120bf33144bfe 342 Gene3D G3DSA:2.120.10.30 58 337 7.2E-47 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS04360 a38ba52ca73ae7cc7eb120bf33144bfe 342 Pfam PF08450 SMP-30/Gluconolaconase/LRE-like region 67 295 7.4E-26 T 09-03-2017 IPR013658 SMP-30/Gluconolactonase/LRE-like region TK78_RS28220 fc3c905aac772d8e65827b3a1d425520 463 Pfam PF07685 CobB/CobQ-like glutamine amidotransferase domain 264 446 8.1E-24 T 09-03-2017 IPR011698 CobB/CobQ-like glutamine amidotransferase GO:0003824|GO:0009236 TK78_RS28220 fc3c905aac772d8e65827b3a1d425520 463 Hamap MF_00027 Cobyrinate a,c-diamide synthase [cbiA]. 4 447 42.301 T 09-03-2017 IPR004484 Cobyrinic acid a,c-diamide synthase CbiA GO:0009236|GO:0042242 TK78_RS28220 fc3c905aac772d8e65827b3a1d425520 463 TIGRFAM TIGR00379 cobB: cobyrinic acid a,c-diamide synthase 6 456 3.0E-123 T 09-03-2017 IPR004484 Cobyrinic acid a,c-diamide synthase CbiA GO:0009236|GO:0042242 TK78_RS28220 fc3c905aac772d8e65827b3a1d425520 463 Gene3D G3DSA:3.40.50.880 263 459 5.7E-31 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS28220 fc3c905aac772d8e65827b3a1d425520 463 Gene3D G3DSA:3.40.50.300 5 195 1.5E-22 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28220 fc3c905aac772d8e65827b3a1d425520 463 SUPERFAMILY SSF52540 6 198 3.75E-43 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28220 fc3c905aac772d8e65827b3a1d425520 463 Pfam PF01656 CobQ/CobB/MinD/ParA nucleotide binding domain 7 194 2.2E-23 T 09-03-2017 IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain TK78_RS28220 fc3c905aac772d8e65827b3a1d425520 463 SUPERFAMILY SSF52317 261 457 1.41E-32 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS01540 c9d17a51c394820c2865244b983fa346 397 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 114 198 6.1E-20 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS01540 c9d17a51c394820c2865244b983fa346 397 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 221 378 6.1E-17 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS01540 c9d17a51c394820c2865244b983fa346 397 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 14 110 2.8E-8 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS01540 c9d17a51c394820c2865244b983fa346 397 Gene3D G3DSA:2.40.110.10 113 210 4.2E-32 T 09-03-2017 TK78_RS01540 c9d17a51c394820c2865244b983fa346 397 Gene3D G3DSA:1.20.140.10 211 388 8.3E-25 T 09-03-2017 TK78_RS01540 c9d17a51c394820c2865244b983fa346 397 SUPERFAMILY SSF56645 26 234 1.01E-60 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS01540 c9d17a51c394820c2865244b983fa346 397 Gene3D G3DSA:1.10.540.10 23 111 9.8E-15 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS01540 c9d17a51c394820c2865244b983fa346 397 SUPERFAMILY SSF47203 221 380 4.75E-14 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS19050 9ad164639ea76e5a89d3e782597623f3 225 Gene3D G3DSA:1.20.58.220 116 212 6.9E-22 T 09-03-2017 TK78_RS19050 9ad164639ea76e5a89d3e782597623f3 225 SUPERFAMILY SSF109755 2 214 8.69E-58 T 09-03-2017 TK78_RS19050 9ad164639ea76e5a89d3e782597623f3 225 Gene3D G3DSA:1.20.58.220 1 105 7.3E-28 T 09-03-2017 TK78_RS19050 9ad164639ea76e5a89d3e782597623f3 225 TIGRFAM TIGR02135 phoU_full: phosphate transport system regulatory protein PhoU 4 212 2.1E-57 T 09-03-2017 IPR028366 Phosphate transport system protein PhoU GO:0005737|GO:0030643|GO:0045936 TK78_RS19050 9ad164639ea76e5a89d3e782597623f3 225 PIRSF PIRSF003107 1 217 2.6E-55 T 09-03-2017 IPR028366 Phosphate transport system protein PhoU GO:0005737|GO:0030643|GO:0045936 TK78_RS19050 9ad164639ea76e5a89d3e782597623f3 225 Pfam PF01895 PhoU domain 16 103 1.3E-16 T 09-03-2017 IPR026022 PhoU domain TK78_RS19050 9ad164639ea76e5a89d3e782597623f3 225 Pfam PF01895 PhoU domain 121 204 3.4E-13 T 09-03-2017 IPR026022 PhoU domain TK78_RS02015 d49649ae21c36ea41f4f43a75a6f3749 214 SUPERFAMILY SSF48498 84 208 3.76E-23 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS02015 d49649ae21c36ea41f4f43a75a6f3749 214 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 34 57 3.1E-5 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS02015 d49649ae21c36ea41f4f43a75a6f3749 214 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 13 26 3.1E-5 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS02015 d49649ae21c36ea41f4f43a75a6f3749 214 Pfam PF00440 Bacterial regulatory proteins, tetR family 13 58 5.2E-11 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS02015 d49649ae21c36ea41f4f43a75a6f3749 214 SUPERFAMILY SSF46689 3 79 1.39E-15 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS02015 d49649ae21c36ea41f4f43a75a6f3749 214 Gene3D G3DSA:1.10.357.10 2 194 1.4E-33 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS10220 7a7979093514c52466249019834bcf8a 398 SUPERFAMILY SSF52343 263 391 2.88E-32 T 09-03-2017 TK78_RS10220 7a7979093514c52466249019834bcf8a 398 Pfam PF00042 Globin 8 105 1.4E-5 T 09-03-2017 IPR000971 Globin GO:0019825|GO:0020037 TK78_RS10220 7a7979093514c52466249019834bcf8a 398 SUPERFAMILY SSF63380 155 261 5.2E-26 T 09-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 TK78_RS10220 7a7979093514c52466249019834bcf8a 398 Pfam PF00970 Oxidoreductase FAD-binding domain 160 259 1.4E-9 T 09-03-2017 IPR008333 Oxidoreductase, FAD-binding domain Reactome: R-HSA-1237044 TK78_RS10220 7a7979093514c52466249019834bcf8a 398 Gene3D G3DSA:3.40.50.80 265 393 3.9E-29 T 09-03-2017 TK78_RS10220 7a7979093514c52466249019834bcf8a 398 Gene3D G3DSA:1.10.490.10 2 145 2.0E-41 T 09-03-2017 IPR012292 Globin/Protoglobin GO:0019825|GO:0020037 TK78_RS10220 7a7979093514c52466249019834bcf8a 398 SUPERFAMILY SSF46458 1 144 3.16E-31 T 09-03-2017 IPR009050 Globin-like TK78_RS10220 7a7979093514c52466249019834bcf8a 398 PRINTS PR00410 Phenol hydroxylase reductase family signature 269 288 2.7E-7 T 09-03-2017 IPR001221 Phenol hydroxylase reductase GO:0055114 TK78_RS10220 7a7979093514c52466249019834bcf8a 398 PRINTS PR00410 Phenol hydroxylase reductase family signature 357 365 2.7E-7 T 09-03-2017 IPR001221 Phenol hydroxylase reductase GO:0055114 TK78_RS10220 7a7979093514c52466249019834bcf8a 398 PRINTS PR00410 Phenol hydroxylase reductase family signature 186 198 2.7E-7 T 09-03-2017 IPR001221 Phenol hydroxylase reductase GO:0055114 TK78_RS10220 7a7979093514c52466249019834bcf8a 398 Gene3D G3DSA:2.40.30.10 155 261 1.7E-30 T 09-03-2017 TK78_RS10220 7a7979093514c52466249019834bcf8a 398 Pfam PF00175 Oxidoreductase NAD-binding domain 272 371 1.9E-14 T 09-03-2017 IPR001433 Oxidoreductase FAD/NAD(P)-binding GO:0016491|GO:0055114 TK78_RS14560 3c1998da381bad6c8ea4d171df65e254 549 Gene3D G3DSA:1.20.144.10 24 204 1.7E-23 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS14560 3c1998da381bad6c8ea4d171df65e254 549 Pfam PF00781 Diacylglycerol kinase catalytic domain 241 360 1.9E-19 T 09-03-2017 IPR001206 Diacylglycerol kinase, catalytic domain GO:0016301 TK78_RS14560 3c1998da381bad6c8ea4d171df65e254 549 SUPERFAMILY SSF111331 238 546 4.09E-59 T 09-03-2017 IPR016064 NAD kinase/diacylglycerol kinase-like domain TK78_RS14560 3c1998da381bad6c8ea4d171df65e254 549 SMART SM00046 240 360 7.7E-4 T 09-03-2017 IPR001206 Diacylglycerol kinase, catalytic domain GO:0016301 TK78_RS14560 3c1998da381bad6c8ea4d171df65e254 549 Pfam PF01569 PAP2 superfamily 96 206 3.5E-15 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS14560 3c1998da381bad6c8ea4d171df65e254 549 SMART SM00014 93 205 1.6E-11 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS14560 3c1998da381bad6c8ea4d171df65e254 549 SUPERFAMILY SSF48317 18 206 2.09E-25 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS14560 3c1998da381bad6c8ea4d171df65e254 549 Gene3D G3DSA:3.40.50.10330 240 332 7.5E-8 T 09-03-2017 IPR017438 Inorganic polyphosphate/ATP-NAD kinase, domain 1 GO:0003951|GO:0008152 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 TK78_RS19970 94bbc4b42b8dce8a8f5061558aea9fba 32 Pfam PF08213 Mitochondrial domain of unknown function (DUF1713) 2 30 3.0E-9 T 09-03-2017 IPR013177 Domain of unknown function DUF1713 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS19970 94bbc4b42b8dce8a8f5061558aea9fba 32 SMART SM01155 1 32 3.8E-5 T 09-03-2017 IPR013177 Domain of unknown function DUF1713 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS21675 e85be68847299641dd9e2635631351d7 239 ProSitePatterns PS00211 ABC transporters family signature. 151 165 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS21675 e85be68847299641dd9e2635631351d7 239 SUPERFAMILY SSF52540 11 233 2.47E-67 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS21675 e85be68847299641dd9e2635631351d7 239 Gene3D G3DSA:3.40.50.300 10 232 5.8E-68 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS21675 e85be68847299641dd9e2635631351d7 239 SMART SM00382 39 226 1.4E-12 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS21675 e85be68847299641dd9e2635631351d7 239 Pfam PF00005 ABC transporter 31 178 2.8E-32 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS26340 40855cb49af26e392767cd77aba2aa4d 998 SUPERFAMILY SSF81593 328 478 2.12E-40 T 09-03-2017 TK78_RS26340 40855cb49af26e392767cd77aba2aa4d 998 SUPERFAMILY SSF81301 72 324 1.21E-68 T 09-03-2017 TK78_RS26340 40855cb49af26e392767cd77aba2aa4d 998 Hamap MF_00802 Glutamate-ammonia-ligase adenylyltransferase [glnE]. 85 984 16.973 T 09-03-2017 IPR023057 Glutamate-ammonia-ligase adenylyltransferase GO:0008882 TK78_RS26340 40855cb49af26e392767cd77aba2aa4d 998 SUPERFAMILY SSF81593 843 993 9.42E-35 T 09-03-2017 TK78_RS26340 40855cb49af26e392767cd77aba2aa4d 998 Gene3D G3DSA:3.30.460.10 165 323 1.1E-55 T 09-03-2017 TK78_RS26340 40855cb49af26e392767cd77aba2aa4d 998 Gene3D G3DSA:3.30.460.10 678 837 3.3E-49 T 09-03-2017 TK78_RS26340 40855cb49af26e392767cd77aba2aa4d 998 SUPERFAMILY SSF81301 554 837 2.91E-59 T 09-03-2017 TK78_RS26340 40855cb49af26e392767cd77aba2aa4d 998 Pfam PF03710 Glutamate-ammonia ligase adenylyltransferase 582 827 2.9E-41 T 09-03-2017 IPR005190 Glutamate-ammonia ligase adenylyltransferase, repeated domain GO:0008882 TK78_RS26340 40855cb49af26e392767cd77aba2aa4d 998 Pfam PF03710 Glutamate-ammonia ligase adenylyltransferase 89 314 9.2E-49 T 09-03-2017 IPR005190 Glutamate-ammonia ligase adenylyltransferase, repeated domain GO:0008882 TK78_RS26340 40855cb49af26e392767cd77aba2aa4d 998 Pfam PF08335 GlnD PII-uridylyltransferase 851 991 2.5E-20 T 09-03-2017 IPR013546 PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase GO:0016779 TK78_RS26340 40855cb49af26e392767cd77aba2aa4d 998 Pfam PF08335 GlnD PII-uridylyltransferase 339 477 4.8E-37 T 09-03-2017 IPR013546 PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase GO:0016779 TK78_RS07225 ee8fd9aaf507b1426dced4e13be9d067 339 Pfam PF13377 Periplasmic binding protein-like domain 172 330 8.8E-38 T 09-03-2017 TK78_RS07225 ee8fd9aaf507b1426dced4e13be9d067 339 Gene3D G3DSA:3.40.50.2300 171 332 2.9E-52 T 09-03-2017 TK78_RS07225 ee8fd9aaf507b1426dced4e13be9d067 339 Pfam PF00356 Bacterial regulatory proteins, lacI family 6 47 2.4E-13 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS07225 ee8fd9aaf507b1426dced4e13be9d067 339 Gene3D G3DSA:1.10.260.40 5 47 3.8E-17 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS07225 ee8fd9aaf507b1426dced4e13be9d067 339 SUPERFAMILY SSF47413 4 50 1.36E-11 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS07225 ee8fd9aaf507b1426dced4e13be9d067 339 SMART SM00354 2 69 2.2E-19 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS07225 ee8fd9aaf507b1426dced4e13be9d067 339 SUPERFAMILY SSF53822 59 335 3.34E-68 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS07225 ee8fd9aaf507b1426dced4e13be9d067 339 Gene3D G3DSA:3.40.50.2300 56 170 1.0E-24 T 09-03-2017 TK78_RS23155 e2931acc1af7fc6265266791e53f11ba 198 Gene3D G3DSA:3.40.50.1240 1 197 3.2E-47 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS23155 e2931acc1af7fc6265266791e53f11ba 198 SMART SM00855 4 153 9.9E-21 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS23155 e2931acc1af7fc6265266791e53f11ba 198 SUPERFAMILY SSF53254 1 197 1.2E-48 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS23155 e2931acc1af7fc6265266791e53f11ba 198 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 5 193 6.8E-49 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS11895 b896f26d6811da249779b39ce232c667 221 Pfam PF01625 Peptide methionine sulfoxide reductase 50 203 7.1E-64 T 09-03-2017 IPR002569 Peptide methionine sulphoxide reductase MsrA GO:0008113|GO:0055114 Reactome: R-HSA-5676934 TK78_RS11895 b896f26d6811da249779b39ce232c667 221 Gene3D G3DSA:3.30.1060.10 26 203 2.9E-76 T 09-03-2017 IPR002569 Peptide methionine sulphoxide reductase MsrA GO:0008113|GO:0055114 Reactome: R-HSA-5676934 TK78_RS11895 b896f26d6811da249779b39ce232c667 221 SUPERFAMILY SSF55068 17 213 5.1E-77 T 09-03-2017 IPR002569 Peptide methionine sulphoxide reductase MsrA GO:0008113|GO:0055114 Reactome: R-HSA-5676934 TK78_RS11895 b896f26d6811da249779b39ce232c667 221 Hamap MF_01401 Peptide methionine sulfoxide reductase MsrA [msrA]. 46 209 37.822 T 09-03-2017 IPR002569 Peptide methionine sulphoxide reductase MsrA GO:0008113|GO:0055114 Reactome: R-HSA-5676934 TK78_RS11895 b896f26d6811da249779b39ce232c667 221 TIGRFAM TIGR00401 msrA: peptide-methionine (S)-S-oxide reductase 48 203 2.3E-63 T 09-03-2017 IPR002569 Peptide methionine sulphoxide reductase MsrA GO:0008113|GO:0055114 Reactome: R-HSA-5676934 TK78_RS08195 f6ecc81a17ccda320332373f1134edbc 112 SMART SM00938 4 105 3.8E-56 T 09-03-2017 IPR002187 Nitrogen regulatory protein PII GO:0006808|GO:0030234 TK78_RS08195 f6ecc81a17ccda320332373f1134edbc 112 PIRSF PIRSF039144 1 112 1.9E-49 T 09-03-2017 IPR002187 Nitrogen regulatory protein PII GO:0006808|GO:0030234 TK78_RS08195 f6ecc81a17ccda320332373f1134edbc 112 SUPERFAMILY SSF54913 1 112 2.26E-41 T 09-03-2017 IPR011322 Nitrogen regulatory PII-like, alpha/beta TK78_RS08195 f6ecc81a17ccda320332373f1134edbc 112 ProSitePatterns PS00496 P-II protein uridylation site. 46 51 - T 09-03-2017 IPR002332 Nitrogen regulatory protein P-II, urydylation site GO:0006808|GO:0030234 TK78_RS08195 f6ecc81a17ccda320332373f1134edbc 112 Pfam PF00543 Nitrogen regulatory protein P-II 4 105 3.8E-39 T 09-03-2017 IPR002187 Nitrogen regulatory protein PII GO:0006808|GO:0030234 TK78_RS08195 f6ecc81a17ccda320332373f1134edbc 112 Gene3D G3DSA:3.30.70.120 1 112 1.5E-45 T 09-03-2017 IPR015867 Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal TK78_RS08195 f6ecc81a17ccda320332373f1134edbc 112 PRINTS PR00340 P-II protein signature 2 17 1.1E-36 T 09-03-2017 IPR002187 Nitrogen regulatory protein PII GO:0006808|GO:0030234 TK78_RS08195 f6ecc81a17ccda320332373f1134edbc 112 PRINTS PR00340 P-II protein signature 52 75 1.1E-36 T 09-03-2017 IPR002187 Nitrogen regulatory protein PII GO:0006808|GO:0030234 TK78_RS08195 f6ecc81a17ccda320332373f1134edbc 112 PRINTS PR00340 P-II protein signature 83 103 1.1E-36 T 09-03-2017 IPR002187 Nitrogen regulatory protein PII GO:0006808|GO:0030234 TK78_RS08195 f6ecc81a17ccda320332373f1134edbc 112 PRINTS PR00340 P-II protein signature 23 41 1.1E-36 T 09-03-2017 IPR002187 Nitrogen regulatory protein PII GO:0006808|GO:0030234 TK78_RS34365 352f4a8d9f0d3ae28f0e2f0702f387ad 289 Pfam PF03537 Glycoside-hydrolase family GH114 61 276 9.7E-53 T 09-03-2017 IPR004352 Glycoside-hydrolase family GH114, TIM-barrel domain TK78_RS34365 352f4a8d9f0d3ae28f0e2f0702f387ad 289 SUPERFAMILY SSF51445 60 258 7.16E-22 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 SMART SM00824 Thioesterase 2923 3128 5.0E-7 T 09-03-2017 IPR020802 Polyketide synthase, thioesterase domain GO:0009058|GO:0016788 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 SUPERFAMILY SSF51735 1440 1703 3.08E-42 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 270 387 6.1E-41 T 09-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 SUPERFAMILY SSF47336 2824 2897 1.83E-15 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 SUPERFAMILY SSF53901 415 436 1.52E-96 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 SUPERFAMILY SSF53901 158 383 1.52E-96 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 SUPERFAMILY SSF53901 10 131 1.52E-96 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Gene3D G3DSA:3.40.47.10 276 440 4.8E-62 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 SMART SM00825 Beta-ketoacyl synthase 13 440 2.4E-208 T 09-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Gene3D G3DSA:3.40.50.980 2465 2630 1.7E-34 T 09-03-2017 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Gene3D G3DSA:3.40.50.980 2297 2464 2.9E-39 T 09-03-2017 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Gene3D G3DSA:3.30.70.250 672 729 7.4E-6 T 09-03-2017 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Pfam PF00550 Phosphopantetheine attachment site 1739 1803 6.8E-11 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Pfam PF00550 Phosphopantetheine attachment site 2835 2896 1.8E-12 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Gene3D G3DSA:3.40.50.720 1444 1678 4.7E-33 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 2327 2747 1.8E-111 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 SUPERFAMILY SSF52777 2018 2257 9.89E-57 T 09-03-2017 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 SUPERFAMILY SSF52151 739 839 1.57E-66 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 SUPERFAMILY SSF52151 546 675 1.57E-66 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 11 262 9.6E-81 T 09-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1445 1639 2.0E-46 T 09-03-2017 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 SUPERFAMILY SSF56801 2258 2844 6.93E-144 T 09-03-2017 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Gene3D G3DSA:3.40.366.10 737 849 2.2E-73 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Gene3D G3DSA:3.40.366.10 546 669 2.2E-73 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2856 2871 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Pfam PF14765 Polyketide synthase dehydratase 908 1187 3.8E-68 T 09-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 SUPERFAMILY SSF51735 1194 1430 7.77E-29 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 SMART SM00823 Phosphopantetheine attachment site 1737 1808 2.6E-13 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 SMART SM00823 Phosphopantetheine attachment site 2832 2901 0.0016 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Gene3D G3DSA:1.10.1200.10 1736 1807 1.9E-10 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Pfam PF00501 AMP-binding enzyme 2302 2723 1.3E-86 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 SUPERFAMILY SSF52777 1835 2008 4.67E-39 T 09-03-2017 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 175 191 - T 09-03-2017 IPR018201 Beta-ketoacyl synthase, active site TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Gene3D G3DSA:2.30.38.10 2631 2712 1.2E-25 T 09-03-2017 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 SMART SM00826 908 1067 3.1E-42 T 09-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Pfam PF00698 Acyl transferase domain 548 865 7.8E-80 T 09-03-2017 IPR014043 Acyl transferase TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Gene3D G3DSA:3.30.300.30 2719 2835 7.1E-37 T 09-03-2017 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Pfam PF00975 Thioesterase domain 2922 3022 4.6E-21 T 09-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Pfam PF13745 HxxPF-repeated domain 2149 2240 8.1E-18 T 09-03-2017 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 SUPERFAMILY SSF53474 2914 3126 4.73E-33 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 391 505 3.4E-14 T 09-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Gene3D G3DSA:3.40.47.10 13 274 6.7E-94 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Pfam PF08659 KR domain 1445 1637 6.8E-56 T 09-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Gene3D G3DSA:3.40.50.1820 3066 3128 2.3E-30 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Gene3D G3DSA:3.40.50.1820 2916 3012 2.3E-30 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 ProSitePatterns PS00455 Putative AMP-binding domain signature. 2456 2467 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Pfam PF13193 AMP-binding enzyme C-terminal domain 2731 2806 5.7E-10 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 550 847 5.8E-108 T 09-03-2017 IPR020801 Polyketide synthase, acyl transferase domain TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Pfam PF00668 Condensation domain 1830 2126 7.6E-64 T 09-03-2017 IPR001242 Condensation domain TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1763 1778 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 SUPERFAMILY SSF55048 673 737 4.19E-11 T 09-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 SUPERFAMILY SSF47336 1731 1811 4.19E-13 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS02630 0820171029082f4b57fef2019d31d8e1 3136 Gene3D G3DSA:1.10.1200.10 2836 2898 5.1E-19 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS16625 f31b3a42e6ec048527576f0f05d51948 329 Gene3D G3DSA:3.40.50.720 105 297 2.1E-37 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS16625 f31b3a42e6ec048527576f0f05d51948 329 SUPERFAMILY SSF51735 106 295 3.24E-31 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS16625 f31b3a42e6ec048527576f0f05d51948 329 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 113 294 1.6E-32 T 09-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 TK78_RS34715 8df9e3dfbc083996fc68522fd8170214 492 Pfam PF00293 NUDIX domain 351 470 5.9E-14 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS34715 8df9e3dfbc083996fc68522fd8170214 492 Pfam PF00293 NUDIX domain 192 305 2.2E-7 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS34715 8df9e3dfbc083996fc68522fd8170214 492 Pfam PF00293 NUDIX domain 51 174 2.1E-15 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS34715 8df9e3dfbc083996fc68522fd8170214 492 SUPERFAMILY SSF55811 350 483 5.42E-20 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS34715 8df9e3dfbc083996fc68522fd8170214 492 Gene3D G3DSA:3.90.79.10 350 481 1.5E-19 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS34715 8df9e3dfbc083996fc68522fd8170214 492 Gene3D G3DSA:3.90.79.10 193 320 2.1E-10 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS34715 8df9e3dfbc083996fc68522fd8170214 492 SUPERFAMILY SSF55811 190 324 7.99E-14 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS34715 8df9e3dfbc083996fc68522fd8170214 492 Gene3D G3DSA:3.90.79.10 48 177 2.3E-22 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS34715 8df9e3dfbc083996fc68522fd8170214 492 SUPERFAMILY SSF55811 36 178 2.57E-22 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS17280 19e0f6d5d18c29868d1e5cf08a0339a5 480 SMART SM00471 266 434 1.2E-4 T 09-03-2017 IPR003607 HD/PDEase domain TK78_RS17280 19e0f6d5d18c29868d1e5cf08a0339a5 480 TIGRFAM TIGR00277 HDIG: HDIG domain 267 344 4.5E-18 T 09-03-2017 IPR006675 HDIG domain TK78_RS17280 19e0f6d5d18c29868d1e5cf08a0339a5 480 Pfam PF01966 HD domain 270 364 5.9E-16 T 09-03-2017 IPR006674 HD domain TK78_RS17280 19e0f6d5d18c29868d1e5cf08a0339a5 480 Pfam PF12627 Probable RNA and SrmB- binding site of polymerase A 195 256 1.0E-20 T 09-03-2017 IPR032828 tRNA nucleotidyltransferase/poly(A) polymerase, RNA and SrmB- binding domain Reactome: R-HSA-6784531|Reactome: R-HSA-6785470 TK78_RS17280 19e0f6d5d18c29868d1e5cf08a0339a5 480 Pfam PF01743 Poly A polymerase head domain 46 168 8.5E-33 T 09-03-2017 IPR002646 Poly A polymerase, head domain GO:0003723|GO:0006396|GO:0016779 Reactome: R-HSA-6784531|Reactome: R-HSA-6785470 TK78_RS17280 19e0f6d5d18c29868d1e5cf08a0339a5 480 SUPERFAMILY SSF81301 26 165 3.38E-37 T 09-03-2017 TK78_RS17280 19e0f6d5d18c29868d1e5cf08a0339a5 480 TIGRFAM TIGR02692 tRNA_CCA_actino: CCA tRNA nucleotidyltransferase 17 477 3.9E-248 T 09-03-2017 IPR014065 tRNA adenylyltransferase TK78_RS17280 19e0f6d5d18c29868d1e5cf08a0339a5 480 Gene3D G3DSA:1.10.3090.10 422 444 3.9E-60 T 09-03-2017 TK78_RS17280 19e0f6d5d18c29868d1e5cf08a0339a5 480 Gene3D G3DSA:1.10.3090.10 168 354 3.9E-60 T 09-03-2017 TK78_RS17280 19e0f6d5d18c29868d1e5cf08a0339a5 480 SUPERFAMILY SSF81891 166 477 8.11E-71 T 09-03-2017 TK78_RS17280 19e0f6d5d18c29868d1e5cf08a0339a5 480 Gene3D G3DSA:3.30.460.10 26 167 1.1E-44 T 09-03-2017 TK78_RS00715 7f8ec973b2906092200e8e1ce1eadaca 804 Gene3D G3DSA:1.50.10.100 40 427 1.7E-111 T 09-03-2017 IPR012329 Polysaccharide lyase family 8, N-terminal GO:0005975|GO:0016837 TK78_RS00715 7f8ec973b2906092200e8e1ce1eadaca 804 SUPERFAMILY SSF74650 414 685 1.2E-89 T 09-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 TK78_RS00715 7f8ec973b2906092200e8e1ce1eadaca 804 SUPERFAMILY SSF48230 40 408 1.98E-106 T 09-03-2017 IPR008929 Chondroitin AC/alginate lyase Reactome: R-HSA-2022923 TK78_RS00715 7f8ec973b2906092200e8e1ce1eadaca 804 Pfam PF02884 Polysaccharide lyase family 8, C-terminal beta-sandwich domain 691 756 4.1E-16 T 09-03-2017 IPR004103 Polysaccharide lyase family 8, C-terminal GO:0005576|GO:0016829 TK78_RS00715 7f8ec973b2906092200e8e1ce1eadaca 804 Pfam PF02278 Polysaccharide lyase family 8, super-sandwich domain 417 676 4.7E-80 T 09-03-2017 IPR003159 Polysaccharide lyase family 8, central domain GO:0005576|GO:0016829 TK78_RS00715 7f8ec973b2906092200e8e1ce1eadaca 804 Pfam PF08124 Polysaccharide lyase family 8, N terminal alpha-helical domain 49 374 3.5E-95 T 09-03-2017 IPR012970 Polysaccharide lyase 8, N-terminal alpha-helical TK78_RS00715 7f8ec973b2906092200e8e1ce1eadaca 804 SUPERFAMILY SSF49863 689 803 7.85E-27 T 09-03-2017 IPR011071 Polysaccharide lyase family 8-like, C-terminal GO:0005975 TK78_RS00715 7f8ec973b2906092200e8e1ce1eadaca 804 Gene3D G3DSA:2.60.220.10 689 803 3.2E-33 T 09-03-2017 IPR004103 Polysaccharide lyase family 8, C-terminal GO:0005576|GO:0016829 TK78_RS00715 7f8ec973b2906092200e8e1ce1eadaca 804 Gene3D G3DSA:2.70.98.10 428 685 3.6E-95 T 09-03-2017 IPR014718 Glycoside hydrolase-type carbohydrate-binding GO:0003824|GO:0005975|GO:0030246 TK78_RS25125 c3f363165edf772901215b1be1fc565c 251 Pfam PF00392 Bacterial regulatory proteins, gntR family 6 65 4.9E-17 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS25125 c3f363165edf772901215b1be1fc565c 251 Gene3D G3DSA:3.40.1410.10 77 232 1.5E-34 T 09-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain TK78_RS25125 c3f363165edf772901215b1be1fc565c 251 SMART SM00345 9 68 7.1E-15 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS25125 c3f363165edf772901215b1be1fc565c 251 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 28 42 1.8E-8 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS25125 c3f363165edf772901215b1be1fc565c 251 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 42 58 1.8E-8 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS25125 c3f363165edf772901215b1be1fc565c 251 SUPERFAMILY SSF64288 56 233 9.11E-36 T 09-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain TK78_RS25125 c3f363165edf772901215b1be1fc565c 251 Pfam PF07702 UTRA domain 90 225 7.3E-26 T 09-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 TK78_RS25125 c3f363165edf772901215b1be1fc565c 251 Gene3D G3DSA:1.10.10.10 3 75 8.3E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS25125 c3f363165edf772901215b1be1fc565c 251 SUPERFAMILY SSF46785 3 72 5.85E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS25125 c3f363165edf772901215b1be1fc565c 251 SMART SM00866 89 229 2.0E-22 T 09-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 TK78_RS29815 932cf5a215148a84efd3b526f30ee71e 403 Pfam PF00202 Aminotransferase class-III 28 389 1.6E-103 T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS29815 932cf5a215148a84efd3b526f30ee71e 403 SUPERFAMILY SSF53383 20 393 4.59E-120 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS29815 932cf5a215148a84efd3b526f30ee71e 403 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 219 257 - T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS29815 932cf5a215148a84efd3b526f30ee71e 403 Hamap MF_01107 Acetylornithine/succinyldiaminopimelate aminotransferase [argD]. 16 393 43.085 T 09-03-2017 IPR004636 Acetylornithine/Succinylornithine transaminase family GO:0006525|GO:0008483 TK78_RS29815 932cf5a215148a84efd3b526f30ee71e 403 Gene3D G3DSA:3.40.640.10 62 286 4.8E-84 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS29815 932cf5a215148a84efd3b526f30ee71e 403 Gene3D G3DSA:3.90.1150.10 287 394 1.9E-35 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS29815 932cf5a215148a84efd3b526f30ee71e 403 TIGRFAM TIGR00707 argD: transaminase, acetylornithine/succinylornithine family 19 392 7.7E-137 T 09-03-2017 IPR004636 Acetylornithine/Succinylornithine transaminase family GO:0006525|GO:0008483 TK78_RS12890 3b6475a8fe804e157371b306b3ac8665 136 Pfam PF01850 PIN domain 3 121 1.1E-9 T 09-03-2017 IPR002716 PIN domain TK78_RS12890 3b6475a8fe804e157371b306b3ac8665 136 Hamap MF_00265 tRNA(fMet)-specific endonuclease VapC [vapC]. 3 128 13.214 T 09-03-2017 IPR022907 VapC family GO:0004540 TK78_RS12890 3b6475a8fe804e157371b306b3ac8665 136 Gene3D G3DSA:3.40.50.1010 3 119 3.2E-7 T 09-03-2017 IPR029060 PIN domain-like TK78_RS12890 3b6475a8fe804e157371b306b3ac8665 136 SUPERFAMILY SSF88723 3 116 4.49E-12 T 09-03-2017 IPR029060 PIN domain-like TK78_RS18935 d74c952135683cc5bb376d3c595b6df2 284 Gene3D G3DSA:3.40.50.1820 5 281 1.1E-36 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS18935 d74c952135683cc5bb376d3c595b6df2 284 SUPERFAMILY SSF53474 3 280 1.68E-28 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS18935 d74c952135683cc5bb376d3c595b6df2 284 Pfam PF12697 Alpha/beta hydrolase family 7 271 2.3E-15 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS02455 3287f4669f675d9d62775f396884c14f 453 Pfam PF00232 Glycosyl hydrolase family 1 6 443 1.7E-155 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS02455 3287f4669f675d9d62775f396884c14f 453 PRINTS PR00131 Glycosyl hydrolase family 1 signature 369 380 4.4E-22 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS02455 3287f4669f675d9d62775f396884c14f 453 PRINTS PR00131 Glycosyl hydrolase family 1 signature 285 299 4.4E-22 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS02455 3287f4669f675d9d62775f396884c14f 453 PRINTS PR00131 Glycosyl hydrolase family 1 signature 348 356 4.4E-22 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS02455 3287f4669f675d9d62775f396884c14f 453 PRINTS PR00131 Glycosyl hydrolase family 1 signature 414 426 4.4E-22 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS02455 3287f4669f675d9d62775f396884c14f 453 PRINTS PR00131 Glycosyl hydrolase family 1 signature 390 407 4.4E-22 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS02455 3287f4669f675d9d62775f396884c14f 453 TIGRFAM TIGR03356 BGL: beta-galactosidase 8 436 2.8E-192 T 09-03-2017 IPR017736 Glycoside hydrolase, family 1, beta-glucosidase GO:0008422|GO:0030245 KEGG: 00460+3.2.1.21|KEGG: 00500+3.2.1.21|KEGG: 00940+3.2.1.21|MetaCyc: PWY-3121|MetaCyc: PWY-5176|MetaCyc: PWY-6002|MetaCyc: PWY-6788|MetaCyc: PWY-7089|MetaCyc: PWY-7091|MetaCyc: PWY-7092 TK78_RS02455 3287f4669f675d9d62775f396884c14f 453 Gene3D G3DSA:3.20.20.80 7 446 8.5E-156 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS02455 3287f4669f675d9d62775f396884c14f 453 ProSitePatterns PS00653 Glycosyl hydrolases family 1 N-terminal signature. 11 25 - T 09-03-2017 IPR033132 Glycosyl hydrolases family 1, N-terminal conserved site TK78_RS02455 3287f4669f675d9d62775f396884c14f 453 SUPERFAMILY SSF51445 7 444 6.0E-158 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS25080 ce1248fb9379a3ac00ce457c85a810de 324 Pfam PF04960 Glutaminase 42 324 5.7E-103 T 09-03-2017 IPR015868 Glutaminase GO:0004359|GO:0006541 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|Reactome: R-HSA-210500|Reactome: R-HSA-5628897|Reactome: R-HSA-70614 TK78_RS25080 ce1248fb9379a3ac00ce457c85a810de 324 SUPERFAMILY SSF56601 25 324 2.99E-97 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS25080 ce1248fb9379a3ac00ce457c85a810de 324 Gene3D G3DSA:3.40.710.10 22 324 1.0E-110 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS25080 ce1248fb9379a3ac00ce457c85a810de 324 TIGRFAM TIGR03814 Gln_ase: glutaminase A 29 324 1.3E-116 T 09-03-2017 IPR015868 Glutaminase GO:0004359|GO:0006541 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|Reactome: R-HSA-210500|Reactome: R-HSA-5628897|Reactome: R-HSA-70614 TK78_RS25080 ce1248fb9379a3ac00ce457c85a810de 324 Hamap MF_00313 Glutaminase [glsA]. 24 324 43.401 T 09-03-2017 IPR015868 Glutaminase GO:0004359|GO:0006541 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|Reactome: R-HSA-210500|Reactome: R-HSA-5628897|Reactome: R-HSA-70614 TK78_RS05260 14b7208d3fc95ef77648af770fb9b277 485 Pfam PF00860 Permease family 45 437 4.7E-38 T 09-03-2017 IPR006043 Xanthine/uracil/vitamin C permease GO:0005215|GO:0006810|GO:0016020|GO:0055085 TK78_RS15135 bc157e82fb01ee970b999ab0082783fd 157 PRINTS PR00502 NUDIX hydrolase family signature 42 56 1.1E-5 T 09-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 TK78_RS15135 bc157e82fb01ee970b999ab0082783fd 157 PRINTS PR00502 NUDIX hydrolase family signature 56 71 1.1E-5 T 09-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 TK78_RS15135 bc157e82fb01ee970b999ab0082783fd 157 SUPERFAMILY SSF55811 11 144 7.99E-27 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS15135 bc157e82fb01ee970b999ab0082783fd 157 Gene3D G3DSA:3.90.79.10 10 145 4.9E-29 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS15135 bc157e82fb01ee970b999ab0082783fd 157 ProSitePatterns PS00893 Nudix box signature. 47 68 - T 09-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 TK78_RS15135 bc157e82fb01ee970b999ab0082783fd 157 Pfam PF00293 NUDIX domain 13 145 2.0E-17 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS02125 a7b5e0299e17f18dd3334b049daa9bee 155 Gene3D G3DSA:2.30.30.110 48 149 1.8E-4 T 09-03-2017 IPR011067 Plasmid maintenance toxin/Cell growth inhibitor TK78_RS02125 a7b5e0299e17f18dd3334b049daa9bee 155 Pfam PF02452 PemK-like, MazF-like toxin of type II toxin-antitoxin system 50 150 6.1E-11 T 09-03-2017 IPR003477 mRNA interferase PemK-like protein GO:0003677 TK78_RS02125 a7b5e0299e17f18dd3334b049daa9bee 155 SUPERFAMILY SSF50118 48 154 7.63E-10 T 09-03-2017 IPR011067 Plasmid maintenance toxin/Cell growth inhibitor TK78_RS03210 a87baebc16fd6f1afa55455470d35004 197 Hamap MF_00202 Isopentenyl-diphosphate Delta-isomerase [idi]. 20 191 31.972 T 09-03-2017 IPR011876 Isopentenyl-diphosphate delta-isomerase, type 1 GO:0004452|GO:0008299 KEGG: 00900+5.3.3.2|MetaCyc: PWY-5123|MetaCyc: PWY-6174|MetaCyc: PWY-6383|MetaCyc: PWY-6859|MetaCyc: PWY-7102|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-7560|MetaCyc: PWY-922|Reactome: R-HSA-191273 TK78_RS03210 a87baebc16fd6f1afa55455470d35004 197 SUPERFAMILY SSF55811 22 182 4.74E-44 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS03210 a87baebc16fd6f1afa55455470d35004 197 PIRSF PIRSF018427 2 192 6.7E-54 T 09-03-2017 IPR011876 Isopentenyl-diphosphate delta-isomerase, type 1 GO:0004452|GO:0008299 KEGG: 00900+5.3.3.2|MetaCyc: PWY-5123|MetaCyc: PWY-6174|MetaCyc: PWY-6383|MetaCyc: PWY-6859|MetaCyc: PWY-7102|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-7560|MetaCyc: PWY-922|Reactome: R-HSA-191273 TK78_RS03210 a87baebc16fd6f1afa55455470d35004 197 Gene3D G3DSA:3.90.79.10 22 183 2.2E-49 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS03210 a87baebc16fd6f1afa55455470d35004 197 TIGRFAM TIGR02150 IPP_isom_1: isopentenyl-diphosphate delta-isomerase 24 179 1.6E-36 T 09-03-2017 IPR011876 Isopentenyl-diphosphate delta-isomerase, type 1 GO:0004452|GO:0008299 KEGG: 00900+5.3.3.2|MetaCyc: PWY-5123|MetaCyc: PWY-6174|MetaCyc: PWY-6383|MetaCyc: PWY-6859|MetaCyc: PWY-7102|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-7560|MetaCyc: PWY-922|Reactome: R-HSA-191273 TK78_RS03210 a87baebc16fd6f1afa55455470d35004 197 Pfam PF00293 NUDIX domain 47 175 3.4E-25 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS30305 086a1b119791d8e30b4f610186388cad 428 SUPERFAMILY SSF51556 51 365 1.34E-100 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS30305 086a1b119791d8e30b4f610186388cad 428 SUPERFAMILY SSF51338 367 427 7.97E-22 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS30305 086a1b119791d8e30b4f610186388cad 428 SUPERFAMILY SSF51338 1 50 7.97E-22 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS30305 086a1b119791d8e30b4f610186388cad 428 Gene3D G3DSA:2.30.40.10 4 64 1.4E-18 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS30305 086a1b119791d8e30b4f610186388cad 428 ProSitePatterns PS00483 Dihydroorotase signature 2. 301 312 - T 09-03-2017 IPR002195 Dihydroorotase, conserved site GO:0016812 KEGG: 00240+3.5.2.3|MetaCyc: PWY-5686 TK78_RS30305 086a1b119791d8e30b4f610186388cad 428 Pfam PF01979 Amidohydrolase family 47 419 3.1E-17 T 09-03-2017 IPR006680 Amidohydrolase-related GO:0016787 TK78_RS30305 086a1b119791d8e30b4f610186388cad 428 Hamap MF_00220_B Dihydroorotase [pyrC]. 3 425 42.87 T 09-03-2017 IPR004722 Dihydroorotase GO:0004151|GO:0006221|GO:0046872 KEGG: 00240+3.5.2.3|MetaCyc: PWY-5686 TK78_RS30305 086a1b119791d8e30b4f610186388cad 428 TIGRFAM TIGR00857 pyrC_multi: dihydroorotase, multifunctional complex type 17 424 2.7E-128 T 09-03-2017 IPR004722 Dihydroorotase GO:0004151|GO:0006221|GO:0046872 KEGG: 00240+3.5.2.3|MetaCyc: PWY-5686 TK78_RS30305 086a1b119791d8e30b4f610186388cad 428 Gene3D G3DSA:3.20.20.140 65 407 2.2E-103 T 09-03-2017 TK78_RS30145 af8932f0b4b81a56e0b22c7001a478d7 873 Pfam PF13291 ACT domain 790 866 1.1E-16 T 09-03-2017 IPR002912 ACT domain GO:0008152|GO:0016597 TK78_RS30145 af8932f0b4b81a56e0b22c7001a478d7 873 Gene3D G3DSA:3.30.70.260 792 864 4.2E-15 T 09-03-2017 TK78_RS30145 af8932f0b4b81a56e0b22c7001a478d7 873 TIGRFAM TIGR00691 spoT_relA: RelA/SpoT family protein 158 866 1.9E-257 T 09-03-2017 IPR004811 RelA/SpoT family GO:0015969 TK78_RS30145 af8932f0b4b81a56e0b22c7001a478d7 873 SMART SM00471 173 283 1.1E-12 T 09-03-2017 IPR003607 HD/PDEase domain TK78_RS30145 af8932f0b4b81a56e0b22c7001a478d7 873 Gene3D G3DSA:3.30.460.10 308 454 6.3E-49 T 09-03-2017 TK78_RS30145 af8932f0b4b81a56e0b22c7001a478d7 873 SUPERFAMILY SSF109604 147 320 1.16E-71 T 09-03-2017 TK78_RS30145 af8932f0b4b81a56e0b22c7001a478d7 873 Pfam PF04607 Region found in RelA / SpoT proteins 365 474 4.5E-37 T 09-03-2017 IPR007685 RelA/SpoT GO:0015969 TK78_RS30145 af8932f0b4b81a56e0b22c7001a478d7 873 Pfam PF13328 HD domain 158 305 3.9E-51 T 09-03-2017 IPR003607 HD/PDEase domain TK78_RS30145 af8932f0b4b81a56e0b22c7001a478d7 873 SUPERFAMILY SSF81271 519 591 3.92E-21 T 09-03-2017 IPR012676 TGS-like KEGG: 00970+6.1.1.3 TK78_RS30145 af8932f0b4b81a56e0b22c7001a478d7 873 SUPERFAMILY SSF55021 789 870 2.83E-15 T 09-03-2017 TK78_RS30145 af8932f0b4b81a56e0b22c7001a478d7 873 SUPERFAMILY SSF81301 310 536 1.16E-62 T 09-03-2017 TK78_RS30145 af8932f0b4b81a56e0b22c7001a478d7 873 SMART SM00954 365 475 2.5E-64 T 09-03-2017 IPR007685 RelA/SpoT GO:0015969 TK78_RS30145 af8932f0b4b81a56e0b22c7001a478d7 873 Pfam PF02824 TGS domain 532 591 1.2E-21 T 09-03-2017 IPR004095 TGS KEGG: 00970+6.1.1.3 TK78_RS30145 af8932f0b4b81a56e0b22c7001a478d7 873 Gene3D G3DSA:3.10.20.30 531 593 4.5E-23 T 09-03-2017 IPR012675 Beta-grasp domain TK78_RS16735 f83e8969e0302511b3e9a91b7ff16952 278 SUPERFAMILY SSF56112 93 277 2.08E-19 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS16735 f83e8969e0302511b3e9a91b7ff16952 278 Pfam PF00069 Protein kinase domain 110 274 6.8E-9 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS16735 f83e8969e0302511b3e9a91b7ff16952 278 Gene3D G3DSA:1.10.510.10 99 275 5.1E-17 T 09-03-2017 TK78_RS16735 f83e8969e0302511b3e9a91b7ff16952 278 SMART SM00220 23 277 0.0071 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS05195 f7d5e3476083a969b1243020c2effedb 803 Gene3D G3DSA:3.60.10.10 494 795 4.7E-31 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS05195 f7d5e3476083a969b1243020c2effedb 803 SUPERFAMILY SSF56219 495 795 9.42E-30 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS05195 f7d5e3476083a969b1243020c2effedb 803 Pfam PF00932 Lamin Tail Domain 29 137 1.6E-9 T 09-03-2017 IPR001322 Lamin Tail Domain TK78_RS05195 f7d5e3476083a969b1243020c2effedb 803 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 497 788 2.1E-13 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS09785 37e909a2bf1f5f23894378bf0ad307e9 137 SMART SM00448 1 111 1.3E-27 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS09785 37e909a2bf1f5f23894378bf0ad307e9 137 SUPERFAMILY SSF52172 1 116 6.26E-35 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS09785 37e909a2bf1f5f23894378bf0ad307e9 137 Pfam PF00072 Response regulator receiver domain 1 111 6.9E-25 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS09785 37e909a2bf1f5f23894378bf0ad307e9 137 Gene3D G3DSA:3.40.50.2300 1 120 6.6E-37 T 09-03-2017 TK78_RS14980 8df6f33a3bc247ccf5fbba3fd5ef6fec 677 Pfam PF00733 Asparagine synthase 240 639 2.3E-25 T 09-03-2017 IPR001962 Asparagine synthase GO:0004066|GO:0006529 TK78_RS14980 8df6f33a3bc247ccf5fbba3fd5ef6fec 677 SUPERFAMILY SSF52402 511 646 2.46E-27 T 09-03-2017 TK78_RS14980 8df6f33a3bc247ccf5fbba3fd5ef6fec 677 SUPERFAMILY SSF52402 220 307 2.46E-27 T 09-03-2017 TK78_RS14980 8df6f33a3bc247ccf5fbba3fd5ef6fec 677 SUPERFAMILY SSF52402 334 409 2.46E-27 T 09-03-2017 TK78_RS14980 8df6f33a3bc247ccf5fbba3fd5ef6fec 677 Gene3D G3DSA:3.40.50.620 221 405 1.1E-24 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS14980 8df6f33a3bc247ccf5fbba3fd5ef6fec 677 Gene3D G3DSA:3.40.50.620 500 647 1.1E-24 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS13405 a24aee3146219d05e49745e9b0d42030 198 SUPERFAMILY SSF54862 34 143 4.6E-19 T 09-03-2017 TK78_RS13405 a24aee3146219d05e49745e9b0d42030 198 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 100 111 - T 09-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TK78_RS13405 a24aee3146219d05e49745e9b0d42030 198 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 51 62 - T 09-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TK78_RS13405 a24aee3146219d05e49745e9b0d42030 198 Pfam PF00037 4Fe-4S binding domain 95 115 8.1E-9 T 09-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TK78_RS13405 a24aee3146219d05e49745e9b0d42030 198 Hamap MF_01351 NAD(P)H-quinone oxidoreductase subunit I, chloroplastic [ndhI]. 3 170 24.304 T 09-03-2017 IPR010226 NADH-quinone oxidoreductase, chain I GO:0016020|GO:0016651|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13405 a24aee3146219d05e49745e9b0d42030 198 Gene3D G3DSA:3.30.70.20 47 133 4.6E-16 T 09-03-2017 TK78_RS23215 02972ed096b4f62c2466279b2976b6db 485 Gene3D G3DSA:3.20.20.80 19 482 2.5E-162 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS23215 02972ed096b4f62c2466279b2976b6db 485 PRINTS PR00131 Glycosyl hydrolase family 1 signature 405 416 2.7E-21 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS23215 02972ed096b4f62c2466279b2976b6db 485 PRINTS PR00131 Glycosyl hydrolase family 1 signature 426 443 2.7E-21 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS23215 02972ed096b4f62c2466279b2976b6db 485 PRINTS PR00131 Glycosyl hydrolase family 1 signature 303 317 2.7E-21 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS23215 02972ed096b4f62c2466279b2976b6db 485 PRINTS PR00131 Glycosyl hydrolase family 1 signature 384 392 2.7E-21 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS23215 02972ed096b4f62c2466279b2976b6db 485 PRINTS PR00131 Glycosyl hydrolase family 1 signature 450 462 2.7E-21 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS23215 02972ed096b4f62c2466279b2976b6db 485 Pfam PF00232 Glycosyl hydrolase family 1 17 479 2.1E-156 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS23215 02972ed096b4f62c2466279b2976b6db 485 TIGRFAM TIGR03356 BGL: beta-galactosidase 20 472 1.2E-179 T 09-03-2017 IPR017736 Glycoside hydrolase, family 1, beta-glucosidase GO:0008422|GO:0030245 KEGG: 00460+3.2.1.21|KEGG: 00500+3.2.1.21|KEGG: 00940+3.2.1.21|MetaCyc: PWY-3121|MetaCyc: PWY-5176|MetaCyc: PWY-6002|MetaCyc: PWY-6788|MetaCyc: PWY-7089|MetaCyc: PWY-7091|MetaCyc: PWY-7092 TK78_RS23215 02972ed096b4f62c2466279b2976b6db 485 SUPERFAMILY SSF51445 19 482 1.81E-157 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS23215 02972ed096b4f62c2466279b2976b6db 485 ProSitePatterns PS00653 Glycosyl hydrolases family 1 N-terminal signature. 24 38 - T 09-03-2017 IPR033132 Glycosyl hydrolases family 1, N-terminal conserved site TK78_RS01165 3258378c43e9ca93a2e68704ce19b43d 201 Pfam PF00440 Bacterial regulatory proteins, tetR family 23 66 7.1E-11 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS01165 3258378c43e9ca93a2e68704ce19b43d 201 SUPERFAMILY SSF46689 11 92 2.54E-15 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS01165 3258378c43e9ca93a2e68704ce19b43d 201 SUPERFAMILY SSF48498 87 182 4.22E-11 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS01165 3258378c43e9ca93a2e68704ce19b43d 201 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 41 64 1.0E-6 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS01165 3258378c43e9ca93a2e68704ce19b43d 201 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 20 33 1.0E-6 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS01165 3258378c43e9ca93a2e68704ce19b43d 201 Gene3D G3DSA:1.10.357.10 10 185 2.3E-32 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS19330 1efef526eeae39d1f3a83336dfbd5014 491 Pfam PF07690 Major Facilitator Superfamily 20 417 4.9E-44 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS19330 1efef526eeae39d1f3a83336dfbd5014 491 Gene3D G3DSA:1.20.1250.20 266 468 9.5E-16 T 09-03-2017 TK78_RS19330 1efef526eeae39d1f3a83336dfbd5014 491 Gene3D G3DSA:1.20.1250.20 17 191 2.2E-27 T 09-03-2017 TK78_RS19330 1efef526eeae39d1f3a83336dfbd5014 491 SUPERFAMILY SSF103473 250 472 1.83E-56 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS19330 1efef526eeae39d1f3a83336dfbd5014 491 SUPERFAMILY SSF103473 7 196 1.83E-56 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS27670 c9411c8cba9d2c416b7b28aed8957425 505 Pfam PF00575 S1 RNA binding domain 36 108 1.3E-15 T 09-03-2017 IPR003029 S1 domain GO:0003676 TK78_RS27670 c9411c8cba9d2c416b7b28aed8957425 505 Pfam PF00575 S1 RNA binding domain 209 280 9.7E-26 T 09-03-2017 IPR003029 S1 domain GO:0003676 TK78_RS27670 c9411c8cba9d2c416b7b28aed8957425 505 Pfam PF00575 S1 RNA binding domain 124 191 1.1E-13 T 09-03-2017 IPR003029 S1 domain GO:0003676 TK78_RS27670 c9411c8cba9d2c416b7b28aed8957425 505 Pfam PF00575 S1 RNA binding domain 294 366 3.6E-23 T 09-03-2017 IPR003029 S1 domain GO:0003676 TK78_RS27670 c9411c8cba9d2c416b7b28aed8957425 505 SUPERFAMILY SSF50249 32 133 3.36E-22 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS27670 c9411c8cba9d2c416b7b28aed8957425 505 SUPERFAMILY SSF50249 113 191 1.34E-14 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS27670 c9411c8cba9d2c416b7b28aed8957425 505 Gene3D G3DSA:2.40.50.140 287 369 1.9E-29 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS27670 c9411c8cba9d2c416b7b28aed8957425 505 Gene3D G3DSA:2.40.50.140 116 192 8.1E-16 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS27670 c9411c8cba9d2c416b7b28aed8957425 505 Gene3D G3DSA:2.40.50.140 30 109 3.1E-18 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS27670 c9411c8cba9d2c416b7b28aed8957425 505 PRINTS PR00681 Ribosomal protein S1 signature 232 253 4.4E-86 T 09-03-2017 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 TK78_RS27670 c9411c8cba9d2c416b7b28aed8957425 505 PRINTS PR00681 Ribosomal protein S1 signature 57 71 4.4E-86 T 09-03-2017 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 TK78_RS27670 c9411c8cba9d2c416b7b28aed8957425 505 PRINTS PR00681 Ribosomal protein S1 signature 129 145 4.4E-86 T 09-03-2017 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 TK78_RS27670 c9411c8cba9d2c416b7b28aed8957425 505 PRINTS PR00681 Ribosomal protein S1 signature 310 329 4.4E-86 T 09-03-2017 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 TK78_RS27670 c9411c8cba9d2c416b7b28aed8957425 505 PRINTS PR00681 Ribosomal protein S1 signature 146 163 4.4E-86 T 09-03-2017 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 TK78_RS27670 c9411c8cba9d2c416b7b28aed8957425 505 PRINTS PR00681 Ribosomal protein S1 signature 175 195 4.4E-86 T 09-03-2017 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 TK78_RS27670 c9411c8cba9d2c416b7b28aed8957425 505 PRINTS PR00681 Ribosomal protein S1 signature 105 124 4.4E-86 T 09-03-2017 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 TK78_RS27670 c9411c8cba9d2c416b7b28aed8957425 505 PRINTS PR00681 Ribosomal protein S1 signature 39 57 4.4E-86 T 09-03-2017 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 TK78_RS27670 c9411c8cba9d2c416b7b28aed8957425 505 PRINTS PR00681 Ribosomal protein S1 signature 349 367 4.4E-86 T 09-03-2017 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 TK78_RS27670 c9411c8cba9d2c416b7b28aed8957425 505 SUPERFAMILY SSF50249 280 368 4.15E-26 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS27670 c9411c8cba9d2c416b7b28aed8957425 505 SMART SM00316 37 108 4.2E-17 T 09-03-2017 IPR022967 RNA-binding domain, S1 TK78_RS27670 c9411c8cba9d2c416b7b28aed8957425 505 SMART SM00316 210 280 1.3E-27 T 09-03-2017 IPR022967 RNA-binding domain, S1 TK78_RS27670 c9411c8cba9d2c416b7b28aed8957425 505 SMART SM00316 124 191 6.5E-11 T 09-03-2017 IPR022967 RNA-binding domain, S1 TK78_RS27670 c9411c8cba9d2c416b7b28aed8957425 505 SMART SM00316 295 366 1.1E-26 T 09-03-2017 IPR022967 RNA-binding domain, S1 TK78_RS27670 c9411c8cba9d2c416b7b28aed8957425 505 Gene3D G3DSA:2.40.50.140 205 286 1.8E-30 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS27670 c9411c8cba9d2c416b7b28aed8957425 505 SUPERFAMILY SSF50249 210 292 3.29E-27 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS33410 ae09f0101a59667ac0eabff9267c952f 253 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 17 251 1.5E-67 T 09-03-2017 TK78_RS33410 ae09f0101a59667ac0eabff9267c952f 253 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 140 148 9.1E-11 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33410 ae09f0101a59667ac0eabff9267c952f 253 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 86 97 9.1E-11 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33410 ae09f0101a59667ac0eabff9267c952f 253 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 160 179 9.1E-11 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33410 ae09f0101a59667ac0eabff9267c952f 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 86 97 7.9E-45 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33410 ae09f0101a59667ac0eabff9267c952f 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 181 198 7.9E-45 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33410 ae09f0101a59667ac0eabff9267c952f 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 214 234 7.9E-45 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33410 ae09f0101a59667ac0eabff9267c952f 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 12 29 7.9E-45 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33410 ae09f0101a59667ac0eabff9267c952f 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 134 150 7.9E-45 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33410 ae09f0101a59667ac0eabff9267c952f 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 160 179 7.9E-45 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33410 ae09f0101a59667ac0eabff9267c952f 253 Gene3D G3DSA:3.40.50.720 6 251 1.2E-86 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS33410 ae09f0101a59667ac0eabff9267c952f 253 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 11 204 0.0082 T 09-03-2017 TK78_RS33410 ae09f0101a59667ac0eabff9267c952f 253 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 147 175 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS33410 ae09f0101a59667ac0eabff9267c952f 253 SUPERFAMILY SSF51735 10 252 1.09E-81 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 Pfam PF14765 Polyketide synthase dehydratase 938 1214 4.6E-53 T 09-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 297 414 3.4E-44 T 09-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 SMART SM00823 Phosphopantetheine attachment site 1687 1759 8.2E-21 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 Pfam PF08659 KR domain 1403 1581 1.3E-56 T 09-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 SUPERFAMILY SSF51735 1402 1640 8.82E-47 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 417 507 7.7E-11 T 09-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 Gene3D G3DSA:3.40.366.10 764 869 2.5E-70 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 Gene3D G3DSA:3.40.366.10 566 698 2.5E-70 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 SUPERFAMILY SSF53901 32 156 3.34E-104 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 SUPERFAMILY SSF53901 185 411 3.34E-104 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 Gene3D G3DSA:3.40.50.720 1402 1587 1.2E-37 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1714 1729 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 Gene3D G3DSA:1.10.1200.10 1685 1758 6.6E-17 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 574 871 6.3E-104 T 09-03-2017 IPR020801 Polyketide synthase, acyl transferase domain TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 Gene3D G3DSA:3.40.47.10 37 301 3.5E-92 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 SUPERFAMILY SSF55048 703 764 2.75E-12 T 09-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 202 218 - T 09-03-2017 IPR018201 Beta-ketoacyl synthase, active site TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 35 289 9.0E-92 T 09-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 SUPERFAMILY SSF47336 1680 1760 4.32E-18 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 Gene3D G3DSA:3.30.70.250 703 763 2.6E-7 T 09-03-2017 TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 Gene3D G3DSA:3.40.47.10 302 469 8.0E-65 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 SMART SM00826 938 1103 5.1E-71 T 09-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 SUPERFAMILY SSF52151 571 704 6.02E-67 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 SUPERFAMILY SSF52151 765 862 6.02E-67 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 SMART SM00825 Beta-ketoacyl synthase 37 467 5.1E-223 T 09-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 Pfam PF00550 Phosphopantetheine attachment site 1701 1754 4.1E-11 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 SUPERFAMILY SSF51735 1221 1387 1.26E-27 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 Pfam PF00698 Acyl transferase domain 574 858 6.5E-49 T 09-03-2017 IPR014043 Acyl transferase TK78_RS31050 5eb3f5e61ba0cebd93c3433cd553b957 1763 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1403 1583 2.0E-58 T 09-03-2017 TK78_RS04205 a324a0fa3308d7d58bd836868724dbf4 593 SUPERFAMILY SSF48179 187 289 3.4E-26 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS04205 a324a0fa3308d7d58bd836868724dbf4 593 Gene3D G3DSA:1.10.1040.10 190 285 2.3E-28 T 09-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 TK78_RS04205 a324a0fa3308d7d58bd836868724dbf4 593 Gene3D G3DSA:1.10.1040.10 496 590 1.8E-31 T 09-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 TK78_RS04205 a324a0fa3308d7d58bd836868724dbf4 593 SUPERFAMILY SSF48179 494 591 1.45E-28 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS04205 a324a0fa3308d7d58bd836868724dbf4 593 Gene3D G3DSA:3.40.50.720 3 189 1.3E-51 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS04205 a324a0fa3308d7d58bd836868724dbf4 593 Gene3D G3DSA:3.40.50.720 311 495 3.1E-53 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS04205 a324a0fa3308d7d58bd836868724dbf4 593 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 188 284 1.2E-27 T 09-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS04205 a324a0fa3308d7d58bd836868724dbf4 593 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 494 590 1.3E-32 T 09-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS04205 a324a0fa3308d7d58bd836868724dbf4 593 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 7 185 2.9E-58 T 09-03-2017 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS04205 a324a0fa3308d7d58bd836868724dbf4 593 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 314 491 4.6E-59 T 09-03-2017 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS04205 a324a0fa3308d7d58bd836868724dbf4 593 SUPERFAMILY SSF51735 312 491 1.5E-50 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS04205 a324a0fa3308d7d58bd836868724dbf4 593 SUPERFAMILY SSF51735 6 187 3.55E-49 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS02615 7fb8e42fd6fa86f0285b069a37aa83fc 351 Gene3D G3DSA:3.90.180.10 2 152 4.7E-29 T 09-03-2017 IPR011032 GroES-like TK78_RS02615 7fb8e42fd6fa86f0285b069a37aa83fc 351 Gene3D G3DSA:3.40.50.720 153 316 4.6E-45 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS02615 7fb8e42fd6fa86f0285b069a37aa83fc 351 SUPERFAMILY SSF50129 4 101 2.74E-16 T 09-03-2017 IPR011032 GroES-like TK78_RS02615 7fb8e42fd6fa86f0285b069a37aa83fc 351 SUPERFAMILY SSF51735 136 302 4.65E-36 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS02615 7fb8e42fd6fa86f0285b069a37aa83fc 351 SMART SM00829 16 349 0.0012 T 09-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 TK78_RS02615 7fb8e42fd6fa86f0285b069a37aa83fc 351 Pfam PF16884 N-terminal domain of oxidoreductase 5 101 4.9E-14 T 09-03-2017 TK78_RS02615 7fb8e42fd6fa86f0285b069a37aa83fc 351 Pfam PF00107 Zinc-binding dehydrogenase 170 293 1.1E-15 T 09-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 TK78_RS00520 0250e65d7dc373cff05b446de135fb2a 275 Gene3D G3DSA:3.40.50.150 46 214 1.7E-21 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS00520 0250e65d7dc373cff05b446de135fb2a 275 SUPERFAMILY SSF53335 34 222 4.91E-28 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS00520 0250e65d7dc373cff05b446de135fb2a 275 Pfam PF08241 Methyltransferase domain 58 149 3.1E-12 T 09-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 TK78_RS11655 b9c3af22c1bf3276f57612b015495444 559 Pfam PF00704 Glycosyl hydrolases family 18 271 540 2.1E-28 T 09-03-2017 IPR001223 Glycoside hydrolase family 18, catalytic domain GO:0004553|GO:0005975 TK78_RS11655 b9c3af22c1bf3276f57612b015495444 559 Pfam PF00041 Fibronectin type III domain 175 245 2.2E-7 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS11655 b9c3af22c1bf3276f57612b015495444 559 SUPERFAMILY SSF49785 27 161 7.65E-12 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS11655 b9c3af22c1bf3276f57612b015495444 559 Gene3D G3DSA:2.60.40.10 173 249 6.5E-21 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS11655 b9c3af22c1bf3276f57612b015495444 559 SMART SM00060 173 243 6.0E-14 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS11655 b9c3af22c1bf3276f57612b015495444 559 SUPERFAMILY SSF51445 266 547 7.69E-57 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS11655 b9c3af22c1bf3276f57612b015495444 559 SUPERFAMILY SSF49265 171 257 2.38E-18 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS11655 b9c3af22c1bf3276f57612b015495444 559 Pfam PF02018 Carbohydrate binding domain 30 143 7.4E-14 T 09-03-2017 IPR003305 Carbohydrate-binding, CenC-like GO:0016798 TK78_RS11655 b9c3af22c1bf3276f57612b015495444 559 SMART SM00636 269 540 8.9E-8 T 09-03-2017 IPR011583 Chitinase II GO:0004568|GO:0006032 TK78_RS11655 b9c3af22c1bf3276f57612b015495444 559 Gene3D G3DSA:2.60.120.260 32 161 4.2E-10 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS11655 b9c3af22c1bf3276f57612b015495444 559 ProSitePatterns PS01095 Chitinases family 18 active site. 377 385 - T 09-03-2017 IPR001579 Glycoside hydrolase, chitinase active site GO:0004553|GO:0005975 KEGG: 00520+3.2.1.14|MetaCyc: PWY-6902 TK78_RS11655 b9c3af22c1bf3276f57612b015495444 559 Gene3D G3DSA:3.20.20.80 268 549 2.5E-62 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS21555 ad3e7445eb398085d9fc3f155b43ccf7 789 SUPERFAMILY SSF81901 543 761 8.28E-34 T 09-03-2017 TK78_RS21555 ad3e7445eb398085d9fc3f155b43ccf7 789 SMART SM00671 506 537 85.0 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS21555 ad3e7445eb398085d9fc3f155b43ccf7 789 SMART SM00671 597 628 140.0 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS21555 ad3e7445eb398085d9fc3f155b43ccf7 789 SMART SM00671 662 693 27.0 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS21555 ad3e7445eb398085d9fc3f155b43ccf7 789 SMART SM00671 538 569 8.2 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS21555 ad3e7445eb398085d9fc3f155b43ccf7 789 SMART SM00671 570 596 120.0 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS21555 ad3e7445eb398085d9fc3f155b43ccf7 789 SMART SM00671 726 757 210.0 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS21555 ad3e7445eb398085d9fc3f155b43ccf7 789 Gene3D G3DSA:1.25.40.10 473 635 4.4E-23 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS21555 ad3e7445eb398085d9fc3f155b43ccf7 789 Gene3D G3DSA:1.25.40.10 636 770 3.6E-24 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS21555 ad3e7445eb398085d9fc3f155b43ccf7 789 Pfam PF13432 Tetratricopeptide repeat 698 753 0.006 T 09-03-2017 TK78_RS21555 ad3e7445eb398085d9fc3f155b43ccf7 789 Pfam PF13432 Tetratricopeptide repeat 639 692 0.017 T 09-03-2017 TK78_RS21555 ad3e7445eb398085d9fc3f155b43ccf7 789 SMART SM00028 726 759 13.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS21555 ad3e7445eb398085d9fc3f155b43ccf7 789 SMART SM00028 630 663 24.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS21555 ad3e7445eb398085d9fc3f155b43ccf7 789 SMART SM00028 538 571 67.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS17800 7a6cc44f6778d758fa5fbbe01d3278b2 608 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 286 452 9.3E-17 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS17800 7a6cc44f6778d758fa5fbbe01d3278b2 608 Pfam PF12806 Acetyl-CoA dehydrogenase C-terminal like 472 604 1.1E-30 T 09-03-2017 IPR025878 Acetyl-CoA dehydrogenase-like C-terminal domain TK78_RS17800 7a6cc44f6778d758fa5fbbe01d3278b2 608 Gene3D G3DSA:1.10.540.10 36 148 1.0E-4 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS17800 7a6cc44f6778d758fa5fbbe01d3278b2 608 SUPERFAMILY SSF47203 290 466 3.87E-31 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS17800 7a6cc44f6778d758fa5fbbe01d3278b2 608 Gene3D G3DSA:2.40.110.10 161 272 1.4E-25 T 09-03-2017 TK78_RS17800 7a6cc44f6778d758fa5fbbe01d3278b2 608 Gene3D G3DSA:1.20.140.10 273 466 2.3E-41 T 09-03-2017 TK78_RS17800 7a6cc44f6778d758fa5fbbe01d3278b2 608 Pfam PF12418 Acyl-CoA dehydrogenase N terminal 3 34 2.6E-10 T 09-03-2017 IPR020953 Acyl-CoA dehydrogenase, N-terminal, bacteria TK78_RS17800 7a6cc44f6778d758fa5fbbe01d3278b2 608 SUPERFAMILY SSF56645 37 282 1.24E-41 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS17800 7a6cc44f6778d758fa5fbbe01d3278b2 608 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 162 272 2.0E-18 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS06750 9beb135706a5f8e3f6f450e004d37aee 354 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 165 311 5.3E-11 T 09-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain TK78_RS06750 9beb135706a5f8e3f6f450e004d37aee 354 Gene3D G3DSA:3.10.180.10 9 165 1.1E-24 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS06750 9beb135706a5f8e3f6f450e004d37aee 354 TIGRFAM TIGR01263 4HPPD: 4-hydroxyphenylpyruvate dioxygenase 13 352 5.5E-107 T 09-03-2017 IPR005956 4-hydroxyphenylpyruvate dioxygenase GO:0003868|GO:0009072|GO:0016701|GO:0055114 TK78_RS06750 9beb135706a5f8e3f6f450e004d37aee 354 Gene3D G3DSA:3.10.180.10 166 352 1.7E-57 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS06750 9beb135706a5f8e3f6f450e004d37aee 354 PIRSF PIRSF009283 2 354 3.1E-111 T 09-03-2017 IPR005956 4-hydroxyphenylpyruvate dioxygenase GO:0003868|GO:0009072|GO:0016701|GO:0055114 TK78_RS06750 9beb135706a5f8e3f6f450e004d37aee 354 SUPERFAMILY SSF54593 12 345 3.72E-70 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS06750 9beb135706a5f8e3f6f450e004d37aee 354 Pfam PF13669 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 15 112 1.5E-7 T 09-03-2017 TK78_RS11495 2029ebc9a2d1f128bb79b69de63c1c92 184 Pfam PF00578 AhpC/TSA family 4 136 1.3E-33 T 09-03-2017 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15|Reactome: R-HSA-3299685 TK78_RS11495 2029ebc9a2d1f128bb79b69de63c1c92 184 PIRSF PIRSF000239 1 184 5.2E-50 T 09-03-2017 IPR024706 Peroxiredoxin, AhpC-type KEGG: 00480+1.11.1.15|Reactome: R-HSA-3299685 TK78_RS11495 2029ebc9a2d1f128bb79b69de63c1c92 184 SUPERFAMILY SSF52833 2 177 5.47E-54 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS11495 2029ebc9a2d1f128bb79b69de63c1c92 184 Gene3D G3DSA:3.40.30.10 2 178 1.0E-61 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS04240 86481d5c57517e0e2ae0b1cdaec504b3 401 Gene3D G3DSA:1.10.540.10 9 123 1.6E-37 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS04240 86481d5c57517e0e2ae0b1cdaec504b3 401 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 245 394 2.3E-47 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS04240 86481d5c57517e0e2ae0b1cdaec504b3 401 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 126 231 7.1E-21 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS04240 86481d5c57517e0e2ae0b1cdaec504b3 401 Gene3D G3DSA:2.40.110.10 125 231 1.7E-32 T 09-03-2017 TK78_RS04240 86481d5c57517e0e2ae0b1cdaec504b3 401 Gene3D G3DSA:1.20.140.10 232 398 8.0E-61 T 09-03-2017 TK78_RS04240 86481d5c57517e0e2ae0b1cdaec504b3 401 SUPERFAMILY SSF56645 10 253 8.25E-70 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS04240 86481d5c57517e0e2ae0b1cdaec504b3 401 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 12 122 2.5E-31 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS04240 86481d5c57517e0e2ae0b1cdaec504b3 401 SUPERFAMILY SSF47203 245 397 2.42E-54 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS01170 838171d3082fe64a538d666728223860 552 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 292 448 1.0E-26 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS01170 838171d3082fe64a538d666728223860 552 Gene3D G3DSA:2.40.110.10 188 284 1.3E-22 T 09-03-2017 TK78_RS01170 838171d3082fe64a538d666728223860 552 SUPERFAMILY SSF56645 57 301 9.03E-37 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS01170 838171d3082fe64a538d666728223860 552 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 188 282 4.1E-20 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS01170 838171d3082fe64a538d666728223860 552 Gene3D G3DSA:1.20.140.10 285 454 4.1E-37 T 09-03-2017 TK78_RS01170 838171d3082fe64a538d666728223860 552 SUPERFAMILY SSF47203 297 452 9.83E-39 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS09910 ea3db9a86741422c0d40467e1aebf2e7 369 Gene3D G3DSA:1.10.620.20 35 254 4.0E-18 T 09-03-2017 IPR012348 Ribonucleotide reductase-related GO:0016491|GO:0055114 Reactome: R-HSA-499943 TK78_RS09910 ea3db9a86741422c0d40467e1aebf2e7 369 Pfam PF11583 P-aminobenzoate N-oxygenase AurF 36 305 9.1E-14 T 09-03-2017 IPR025859 P-aminobenzoate N-oxygenase AurF TK78_RS09910 ea3db9a86741422c0d40467e1aebf2e7 369 SUPERFAMILY SSF47240 89 318 4.24E-68 T 09-03-2017 IPR009078 Ferritin-like superfamily TK78_RS21340 a149207eec42e065f70584b4b58b5461 909 SUPERFAMILY SSF51621 16 909 2.51E-271 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS21340 a149207eec42e065f70584b4b58b5461 909 ProSitePatterns PS00781 Phosphoenolpyruvate carboxylase active site 1. 131 142 - T 09-03-2017 IPR018129 Phosphoenolpyruvate carboxylase, Lys active site KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 TK78_RS21340 a149207eec42e065f70584b4b58b5461 909 PRINTS PR00150 Phosphoenolpyruvate carboxylase signature 735 761 3.2E-57 T 09-03-2017 IPR021135 Phosphoenolpyruvate carboxylase GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 TK78_RS21340 a149207eec42e065f70584b4b58b5461 909 PRINTS PR00150 Phosphoenolpyruvate carboxylase signature 392 412 3.2E-57 T 09-03-2017 IPR021135 Phosphoenolpyruvate carboxylase GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 TK78_RS21340 a149207eec42e065f70584b4b58b5461 909 PRINTS PR00150 Phosphoenolpyruvate carboxylase signature 556 576 3.2E-57 T 09-03-2017 IPR021135 Phosphoenolpyruvate carboxylase GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 TK78_RS21340 a149207eec42e065f70584b4b58b5461 909 PRINTS PR00150 Phosphoenolpyruvate carboxylase signature 130 143 3.2E-57 T 09-03-2017 IPR021135 Phosphoenolpyruvate carboxylase GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 TK78_RS21340 a149207eec42e065f70584b4b58b5461 909 PRINTS PR00150 Phosphoenolpyruvate carboxylase signature 237 252 3.2E-57 T 09-03-2017 IPR021135 Phosphoenolpyruvate carboxylase GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 TK78_RS21340 a149207eec42e065f70584b4b58b5461 909 PRINTS PR00150 Phosphoenolpyruvate carboxylase signature 598 627 3.2E-57 T 09-03-2017 IPR021135 Phosphoenolpyruvate carboxylase GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 TK78_RS21340 a149207eec42e065f70584b4b58b5461 909 PRINTS PR00150 Phosphoenolpyruvate carboxylase signature 179 195 3.2E-57 T 09-03-2017 IPR021135 Phosphoenolpyruvate carboxylase GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 TK78_RS21340 a149207eec42e065f70584b4b58b5461 909 Hamap MF_00595 Phosphoenolpyruvate carboxylase [ppc]. 3 909 18.104 T 09-03-2017 IPR022805 Phosphoenolpyruvate carboxylase, bacterial/plant-type GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 TK78_RS21340 a149207eec42e065f70584b4b58b5461 909 Pfam PF00311 Phosphoenolpyruvate carboxylase 126 909 1.2E-284 T 09-03-2017 IPR021135 Phosphoenolpyruvate carboxylase GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 TK78_RS21340 a149207eec42e065f70584b4b58b5461 909 Gene3D G3DSA:1.20.1440.90 272 394 1.6E-22 T 09-03-2017 TK78_RS21340 a149207eec42e065f70584b4b58b5461 909 ProSitePatterns PS00393 Phosphoenolpyruvate carboxylase active site 2. 558 570 - T 09-03-2017 IPR033129 Phosphoenolpyruvate carboxylase, His active site KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 TK78_RS22080 49d4667a8d2332ed9124161dab36c57c 380 SUPERFAMILY SSF100950 20 361 6.98E-93 T 09-03-2017 TK78_RS22080 49d4667a8d2332ed9124161dab36c57c 380 Pfam PF01008 Initiation factor 2 subunit family 87 361 2.8E-60 T 09-03-2017 IPR000649 Initiation factor 2B-related GO:0044237 KEGG: 00270+5.3.1.23|MetaCyc: PWY-4361|MetaCyc: PWY-7174 TK78_RS22080 49d4667a8d2332ed9124161dab36c57c 380 Hamap MF_01678 Putative methylthioribose-1-phosphate isomerase [mtnA]. 16 371 34.674 T 09-03-2017 IPR005251 Methylthioribose-1-phosphate isomerase GO:0044249 KEGG: 00270+5.3.1.23|MetaCyc: PWY-4361|MetaCyc: PWY-7174|Reactome: R-HSA-1237112 TK78_RS22080 49d4667a8d2332ed9124161dab36c57c 380 TIGRFAM TIGR00524 eIF-2B_rel: eIF-2B alpha/beta/delta-related uncharacterized proteins 48 361 5.8E-81 T 09-03-2017 IPR011559 Initiation factor 2B alpha/beta/delta GO:0044249 KEGG: 00270+5.3.1.23|MetaCyc: PWY-4361|MetaCyc: PWY-7174|Reactome: R-HSA-1237112 TK78_RS22080 49d4667a8d2332ed9124161dab36c57c 380 Gene3D G3DSA:3.40.50.10470 174 362 2.6E-56 T 09-03-2017 TK78_RS22080 49d4667a8d2332ed9124161dab36c57c 380 TIGRFAM TIGR00512 salvage_mtnA: S-methyl-5-thioribose-1-phosphate isomerase 30 360 9.4E-103 T 09-03-2017 IPR005251 Methylthioribose-1-phosphate isomerase GO:0044249 KEGG: 00270+5.3.1.23|MetaCyc: PWY-4361|MetaCyc: PWY-7174|Reactome: R-HSA-1237112 TK78_RS22080 49d4667a8d2332ed9124161dab36c57c 380 Gene3D G3DSA:1.20.120.420 21 173 6.5E-36 T 09-03-2017 IPR027363 Methylthioribose-1-phosphate isomerase-like, N-terminal domain KEGG: 00270+5.3.1.23|MetaCyc: PWY-4361|MetaCyc: PWY-7174|Reactome: R-HSA-1237112 TK78_RS16685 b33f9c91f1b14a4716725def58bf440f 317 Gene3D G3DSA:1.10.1740.10 11 76 6.7E-14 T 09-03-2017 TK78_RS16685 b33f9c91f1b14a4716725def58bf440f 317 Gene3D G3DSA:1.10.10.10 109 163 4.9E-11 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS16685 b33f9c91f1b14a4716725def58bf440f 317 Pfam PF08281 Sigma-70, region 4 111 162 1.3E-10 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16685 b33f9c91f1b14a4716725def58bf440f 317 SUPERFAMILY SSF88946 11 91 2.31E-13 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16685 b33f9c91f1b14a4716725def58bf440f 317 Pfam PF04542 Sigma-70 region 2 12 74 1.0E-15 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16685 b33f9c91f1b14a4716725def58bf440f 317 SUPERFAMILY SSF88659 86 163 1.44E-9 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16685 b33f9c91f1b14a4716725def58bf440f 317 SUPERFAMILY SSF54427 172 294 5.38E-10 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS16685 b33f9c91f1b14a4716725def58bf440f 317 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 11 162 4.5E-14 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16685 b33f9c91f1b14a4716725def58bf440f 317 Gene3D G3DSA:3.10.450.50 171 294 7.5E-9 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS33785 c263928b8fe9db30ed95a51bef9f859f 496 Gene3D G3DSA:1.10.260.40 4 71 1.5E-18 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS33785 c263928b8fe9db30ed95a51bef9f859f 496 SMART SM00530 9 64 2.6E-16 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS33785 c263928b8fe9db30ed95a51bef9f859f 496 Pfam PF06114 Domain of unknown function (DUF955) 222 332 1.0E-20 T 09-03-2017 IPR010359 HTH domain, IrrE-type TK78_RS33785 c263928b8fe9db30ed95a51bef9f859f 496 SUPERFAMILY SSF47413 5 66 2.09E-15 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS33785 c263928b8fe9db30ed95a51bef9f859f 496 Pfam PF09856 Predicted transcriptional regulator (DUF2083) 333 489 9.4E-72 T 09-03-2017 IPR018653 Domain of unknown function DUF2083,transcriptional regulator TK78_RS33785 c263928b8fe9db30ed95a51bef9f859f 496 Pfam PF13560 Helix-turn-helix domain 7 61 1.7E-13 T 09-03-2017 TK78_RS03400 fcac7c48bd016840abb2fe918cdcfbcd 743 SUPERFAMILY SSF52540 549 704 8.61E-39 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03400 fcac7c48bd016840abb2fe918cdcfbcd 743 SUPERFAMILY SSF52540 420 461 8.61E-39 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03400 fcac7c48bd016840abb2fe918cdcfbcd 743 Gene3D G3DSA:1.10.150.20 94 136 2.7E-4 T 09-03-2017 TK78_RS03400 fcac7c48bd016840abb2fe918cdcfbcd 743 Pfam PF00271 Helicase conserved C-terminal domain 559 669 3.5E-8 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS03400 fcac7c48bd016840abb2fe918cdcfbcd 743 Gene3D G3DSA:3.40.50.300 304 474 2.2E-17 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03400 fcac7c48bd016840abb2fe918cdcfbcd 743 SMART SM00490 585 669 3.4E-8 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS03400 fcac7c48bd016840abb2fe918cdcfbcd 743 Gene3D G3DSA:3.40.50.300 552 705 3.6E-12 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03400 fcac7c48bd016840abb2fe918cdcfbcd 743 Pfam PF00176 SNF2 family N-terminal domain 326 516 5.4E-25 T 09-03-2017 IPR000330 SNF2-related, N-terminal domain GO:0005524 TK78_RS03400 fcac7c48bd016840abb2fe918cdcfbcd 743 SUPERFAMILY SSF52540 300 485 4.26E-38 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03400 fcac7c48bd016840abb2fe918cdcfbcd 743 SMART SM00487 304 487 2.8E-20 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS13170 d35654293dc2e94d70aeab4558b9f5eb 102 Hamap MF_00508 30S ribosomal protein S10 [rpsJ]. 3 102 27.897 T 09-03-2017 IPR001848 Ribosomal protein S10 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13170 d35654293dc2e94d70aeab4558b9f5eb 102 PRINTS PR00971 Ribosomal protein S10 family signature 5 18 4.6E-21 T 09-03-2017 IPR001848 Ribosomal protein S10 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13170 d35654293dc2e94d70aeab4558b9f5eb 102 PRINTS PR00971 Ribosomal protein S10 family signature 61 75 4.6E-21 T 09-03-2017 IPR001848 Ribosomal protein S10 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13170 d35654293dc2e94d70aeab4558b9f5eb 102 PRINTS PR00971 Ribosomal protein S10 family signature 40 55 4.6E-21 T 09-03-2017 IPR001848 Ribosomal protein S10 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13170 d35654293dc2e94d70aeab4558b9f5eb 102 SUPERFAMILY SSF54999 5 102 1.02E-38 T 09-03-2017 IPR027486 Ribosomal protein S10 domain TK78_RS13170 d35654293dc2e94d70aeab4558b9f5eb 102 Pfam PF00338 Ribosomal protein S10p/S20e 7 101 7.9E-37 T 09-03-2017 IPR027486 Ribosomal protein S10 domain TK78_RS13170 d35654293dc2e94d70aeab4558b9f5eb 102 SMART SM01403 7 101 3.5E-59 T 09-03-2017 IPR027486 Ribosomal protein S10 domain TK78_RS13170 d35654293dc2e94d70aeab4558b9f5eb 102 Gene3D G3DSA:3.30.70.600 4 102 5.6E-45 T 09-03-2017 IPR027486 Ribosomal protein S10 domain TK78_RS13170 d35654293dc2e94d70aeab4558b9f5eb 102 TIGRFAM TIGR01049 rpsJ_bact: ribosomal protein uS10 4 101 1.1E-47 T 09-03-2017 IPR001848 Ribosomal protein S10 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13170 d35654293dc2e94d70aeab4558b9f5eb 102 ProSitePatterns PS00361 Ribosomal protein S10 signature. 29 44 - T 09-03-2017 IPR018268 Ribosomal protein S10, conserved site GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS07025 dee956bd30fd645b8f0f2c83a9b6c6db 349 SUPERFAMILY SSF51735 1 318 2.52E-95 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07025 dee956bd30fd645b8f0f2c83a9b6c6db 349 Pfam PF16363 GDP-mannose 4,6 dehydratase 4 304 8.1E-77 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07025 dee956bd30fd645b8f0f2c83a9b6c6db 349 TIGRFAM TIGR01181 dTDP_gluc_dehyt: dTDP-glucose 4,6-dehydratase 2 318 4.6E-126 T 09-03-2017 IPR005888 dTDP-glucose 4,6-dehydratase GO:0008460|GO:0009225 KEGG: 00521+4.2.1.46|KEGG: 00523+4.2.1.46|MetaCyc: PWY-3221|MetaCyc: PWY-6808|MetaCyc: PWY-6942|MetaCyc: PWY-6953|MetaCyc: PWY-6973|MetaCyc: PWY-6974|MetaCyc: PWY-6976|MetaCyc: PWY-7104|MetaCyc: PWY-7301|MetaCyc: PWY-7312|MetaCyc: PWY-7315|MetaCyc: PWY-7316|MetaCyc: PWY-7318|MetaCyc: PWY-7413|MetaCyc: PWY-7414|MetaCyc: PWY-7440|MetaCyc: PWY-7657|MetaCyc: PWY-7688 TK78_RS07025 dee956bd30fd645b8f0f2c83a9b6c6db 349 Gene3D G3DSA:3.90.25.10 183 318 5.2E-48 T 09-03-2017 TK78_RS07025 dee956bd30fd645b8f0f2c83a9b6c6db 349 Gene3D G3DSA:3.40.50.720 1 182 4.7E-62 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS06130 241a7e83a7e978d73bc4593ab0f1e630 319 Pfam PF00656 Caspase domain 2 143 8.8E-14 T 09-03-2017 TK78_RS06130 241a7e83a7e978d73bc4593ab0f1e630 319 Gene3D G3DSA:3.40.50.1460 2 136 1.1E-11 T 09-03-2017 IPR029030 Caspase-like domain TK78_RS06130 241a7e83a7e978d73bc4593ab0f1e630 319 SUPERFAMILY SSF52129 2 182 8.58E-9 T 09-03-2017 IPR029030 Caspase-like domain TK78_RS14585 25bd10743ee0bbb42175909b9c38e1bb 329 Pfam PF00248 Aldo/keto reductase family 15 316 7.0E-69 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS14585 25bd10743ee0bbb42175909b9c38e1bb 329 Gene3D G3DSA:3.20.20.100 1 317 2.9E-94 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS14585 25bd10743ee0bbb42175909b9c38e1bb 329 SUPERFAMILY SSF51430 1 319 4.71E-93 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS10060 9caa08588557a3f9666cd5f66472b142 320 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3 69 305 7.3E-59 T 09-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF TK78_RS10060 9caa08588557a3f9666cd5f66472b142 320 Gene3D G3DSA:3.40.190.10 65 158 2.7E-33 T 09-03-2017 TK78_RS10060 9caa08588557a3f9666cd5f66472b142 320 Gene3D G3DSA:3.40.190.10 267 305 2.7E-33 T 09-03-2017 TK78_RS10060 9caa08588557a3f9666cd5f66472b142 320 SMART SM00062 68 308 3.8E-50 T 09-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF TK78_RS10060 9caa08588557a3f9666cd5f66472b142 320 Gene3D G3DSA:3.40.190.10 159 265 2.4E-20 T 09-03-2017 TK78_RS10060 9caa08588557a3f9666cd5f66472b142 320 SUPERFAMILY SSF53850 18 305 2.39E-54 T 09-03-2017 TK78_RS03160 bfc26e72066c589f1862162ceebb56ca 303 Gene3D G3DSA:1.10.600.10 19 292 2.0E-48 T 09-03-2017 IPR008949 Isoprenoid synthase domain TK78_RS03160 bfc26e72066c589f1862162ceebb56ca 303 Pfam PF00494 Squalene/phytoene synthase 16 284 2.9E-66 T 09-03-2017 IPR002060 Squalene/phytoene synthase GO:0009058|GO:0016740 TK78_RS03160 bfc26e72066c589f1862162ceebb56ca 303 SUPERFAMILY SSF48576 15 298 6.71E-57 T 09-03-2017 IPR008949 Isoprenoid synthase domain TK78_RS03160 bfc26e72066c589f1862162ceebb56ca 303 TIGRFAM TIGR03464 HpnC: squalene synthase HpnC 15 293 8.5E-95 T 09-03-2017 IPR017827 Squalene synthase HpnC TK78_RS16885 16d8b9b3ddcd81b547425cbf8a7c3f6c 489 SUPERFAMILY SSF57938 321 355 2.49E-5 T 09-03-2017 IPR001305 Heat shock protein DnaJ, cysteine-rich domain GO:0031072|GO:0051082 TK78_RS16885 16d8b9b3ddcd81b547425cbf8a7c3f6c 489 Gene3D G3DSA:2.10.230.10 321 355 4.5E-5 T 09-03-2017 IPR001305 Heat shock protein DnaJ, cysteine-rich domain GO:0031072|GO:0051082 TK78_RS11490 0e131359177c2361405a3fba2cc5c4d6 329 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 23 82 4.6E-19 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS11490 0e131359177c2361405a3fba2cc5c4d6 329 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 38 49 2.6E-7 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS11490 0e131359177c2361405a3fba2cc5c4d6 329 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 49 59 2.6E-7 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS11490 0e131359177c2361405a3fba2cc5c4d6 329 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 59 70 2.6E-7 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS11490 0e131359177c2361405a3fba2cc5c4d6 329 SUPERFAMILY SSF46785 21 130 7.37E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS11490 0e131359177c2361405a3fba2cc5c4d6 329 Gene3D G3DSA:1.10.10.10 22 105 3.0E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS11490 0e131359177c2361405a3fba2cc5c4d6 329 Gene3D G3DSA:3.40.190.10 110 194 2.1E-19 T 09-03-2017 TK78_RS11490 0e131359177c2361405a3fba2cc5c4d6 329 Pfam PF03466 LysR substrate binding domain 108 316 2.1E-44 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS11490 0e131359177c2361405a3fba2cc5c4d6 329 SUPERFAMILY SSF53850 109 321 2.76E-38 T 09-03-2017 TK78_RS11490 0e131359177c2361405a3fba2cc5c4d6 329 Gene3D G3DSA:3.40.190.10 195 290 6.5E-26 T 09-03-2017 TK78_RS25765 6d7fef8e01f77b1e4f3e3fd756814190 389 SUPERFAMILY SSF56574 49 377 1.7E-43 T 09-03-2017 IPR023796 Serpin domain TK78_RS25765 6d7fef8e01f77b1e4f3e3fd756814190 389 Gene3D G3DSA:3.30.497.10 48 175 2.3E-33 T 09-03-2017 TK78_RS25765 6d7fef8e01f77b1e4f3e3fd756814190 389 Gene3D G3DSA:3.30.497.10 279 333 2.3E-33 T 09-03-2017 TK78_RS25765 6d7fef8e01f77b1e4f3e3fd756814190 389 Pfam PF00079 Serpin (serine protease inhibitor) 51 377 6.4E-39 T 09-03-2017 IPR023796 Serpin domain TK78_RS25765 6d7fef8e01f77b1e4f3e3fd756814190 389 SMART SM00093 40 383 8.5E-9 T 09-03-2017 IPR023796 Serpin domain TK78_RS25765 6d7fef8e01f77b1e4f3e3fd756814190 389 Gene3D G3DSA:2.30.39.10 176 278 3.0E-9 T 09-03-2017 TK78_RS25765 6d7fef8e01f77b1e4f3e3fd756814190 389 Gene3D G3DSA:2.30.39.10 334 377 3.0E-9 T 09-03-2017 TK78_RS22270 1df8bacd5362b84f963570d8d3c8a2b9 395 SUPERFAMILY SSF50156 90 200 2.8E-15 T 09-03-2017 IPR001478 PDZ domain GO:0005515 TK78_RS22270 1df8bacd5362b84f963570d8d3c8a2b9 395 Gene3D G3DSA:3.90.226.10 200 381 2.3E-43 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS22270 1df8bacd5362b84f963570d8d3c8a2b9 395 Pfam PF13180 PDZ domain 114 192 1.2E-7 T 09-03-2017 IPR001478 PDZ domain GO:0005515 TK78_RS22270 1df8bacd5362b84f963570d8d3c8a2b9 395 SMART SM00245 190 377 7.7E-34 T 09-03-2017 IPR005151 Tail specific protease GO:0006508|GO:0008236 Reactome: R-HSA-2187335|Reactome: R-HSA-2453902 TK78_RS22270 1df8bacd5362b84f963570d8d3c8a2b9 395 Pfam PF03572 Peptidase family S41 222 376 8.4E-37 T 09-03-2017 IPR005151 Tail specific protease GO:0006508|GO:0008236 Reactome: R-HSA-2187335|Reactome: R-HSA-2453902 TK78_RS22270 1df8bacd5362b84f963570d8d3c8a2b9 395 SUPERFAMILY SSF52096 191 377 1.16E-42 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS22270 1df8bacd5362b84f963570d8d3c8a2b9 395 SUPERFAMILY SSF52096 73 106 1.16E-42 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS22270 1df8bacd5362b84f963570d8d3c8a2b9 395 Gene3D G3DSA:2.30.42.10 113 199 3.3E-16 T 09-03-2017 IPR001478 PDZ domain GO:0005515 TK78_RS22270 1df8bacd5362b84f963570d8d3c8a2b9 395 SMART SM00228 113 190 7.6E-7 T 09-03-2017 IPR001478 PDZ domain GO:0005515 TK78_RS33225 c781c4dcf2ab7aadf5994a6395a47c7c 347 Pfam PF01032 FecCD transport family 33 341 6.3E-86 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS33225 c781c4dcf2ab7aadf5994a6395a47c7c 347 Gene3D G3DSA:1.10.3470.10 22 343 1.6E-96 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS33225 c781c4dcf2ab7aadf5994a6395a47c7c 347 SUPERFAMILY SSF81345 20 341 8.89E-78 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS02730 be894323d1736fdeff6555e69064eea1 134 Pfam PF09851 Short C-terminal domain 108 133 9.1E-9 T 09-03-2017 IPR018649 SHOCT domain TK78_RS02730 be894323d1736fdeff6555e69064eea1 134 Pfam PF13396 Phospholipase_D-nuclease N-terminal 20 66 6.4E-8 T 09-03-2017 IPR027379 Cardiolipin synthase N-terminal TK78_RS23930 429d7a11da1ac0c84b65243d6447937d 401 Pfam PF00294 pfkB family carbohydrate kinase 8 325 8.6E-45 T 09-03-2017 IPR011611 Carbohydrate kinase PfkB TK78_RS23930 429d7a11da1ac0c84b65243d6447937d 401 Gene3D G3DSA:3.40.1190.20 1 337 1.7E-100 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS23930 429d7a11da1ac0c84b65243d6447937d 401 SUPERFAMILY SSF53613 4 334 1.36E-67 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS23930 429d7a11da1ac0c84b65243d6447937d 401 TIGRFAM TIGR04382 myo_inos_iolC_N: 5-dehydro-2-deoxygluconokinase 5 333 9.9E-107 T 09-03-2017 IPR030830 5-dehydro-2-deoxygluconokinase KEGG: 00562+2.7.1.92 TK78_RS15255 d11ce834058972a671ad6924176e3fd2 225 Pfam PF00072 Response regulator receiver domain 4 116 1.9E-25 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS15255 d11ce834058972a671ad6924176e3fd2 225 Pfam PF00196 Bacterial regulatory proteins, luxR family 155 210 2.9E-15 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS15255 d11ce834058972a671ad6924176e3fd2 225 SUPERFAMILY SSF52172 2 132 1.12E-31 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS15255 d11ce834058972a671ad6924176e3fd2 225 Gene3D G3DSA:1.10.10.10 157 215 7.6E-25 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS15255 d11ce834058972a671ad6924176e3fd2 225 SMART SM00421 153 210 2.7E-21 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS15255 d11ce834058972a671ad6924176e3fd2 225 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 156 170 7.5E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS15255 d11ce834058972a671ad6924176e3fd2 225 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 170 186 7.5E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS15255 d11ce834058972a671ad6924176e3fd2 225 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 186 198 7.5E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS15255 d11ce834058972a671ad6924176e3fd2 225 SMART SM00448 2 115 6.9E-28 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS15255 d11ce834058972a671ad6924176e3fd2 225 Gene3D G3DSA:3.40.50.2300 2 156 1.4E-36 T 09-03-2017 TK78_RS15255 d11ce834058972a671ad6924176e3fd2 225 SUPERFAMILY SSF46894 147 215 1.46E-19 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS28835 b87e3f8c1432c97b2e0c2b0dd5dd4e51 426 TIGRFAM TIGR03860 FMN_nitrolo: FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family 9 416 4.6E-119 T 09-03-2017 IPR016215 Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A GO:0004497 TK78_RS28835 b87e3f8c1432c97b2e0c2b0dd5dd4e51 426 Pfam PF00296 Luciferase-like monooxygenase 20 335 8.4E-58 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS28835 b87e3f8c1432c97b2e0c2b0dd5dd4e51 426 PIRSF PIRSF000337 1 425 2.1E-135 T 09-03-2017 IPR016215 Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A GO:0004497 TK78_RS28835 b87e3f8c1432c97b2e0c2b0dd5dd4e51 426 SUPERFAMILY SSF51679 1 422 9.97E-106 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS28835 b87e3f8c1432c97b2e0c2b0dd5dd4e51 426 Gene3D G3DSA:3.20.20.30 1 286 1.7E-113 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS28835 b87e3f8c1432c97b2e0c2b0dd5dd4e51 426 Gene3D G3DSA:3.20.20.30 337 422 1.7E-113 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS31675 32977178404cfc6fae9687a14494d96b 181 SUPERFAMILY SSF56420 13 170 4.84E-54 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS31675 32977178404cfc6fae9687a14494d96b 181 Gene3D G3DSA:3.90.45.10 17 177 1.5E-58 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS31675 32977178404cfc6fae9687a14494d96b 181 PIRSF PIRSF004749 4 179 1.3E-42 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS31675 32977178404cfc6fae9687a14494d96b 181 TIGRFAM TIGR00079 pept_deformyl: peptide deformylase 19 168 1.1E-36 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS31675 32977178404cfc6fae9687a14494d96b 181 Hamap MF_00163 Peptide deformylase [def]. 12 175 27.275 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS31675 32977178404cfc6fae9687a14494d96b 181 PRINTS PR01576 Peptide deformylase signature 43 72 3.9E-31 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS31675 32977178404cfc6fae9687a14494d96b 181 PRINTS PR01576 Peptide deformylase signature 102 113 3.9E-31 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS31675 32977178404cfc6fae9687a14494d96b 181 PRINTS PR01576 Peptide deformylase signature 114 132 3.9E-31 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS31675 32977178404cfc6fae9687a14494d96b 181 PRINTS PR01576 Peptide deformylase signature 133 162 3.9E-31 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS31675 32977178404cfc6fae9687a14494d96b 181 Pfam PF01327 Polypeptide deformylase 15 164 1.1E-43 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS08525 a96da7765999556dd538a1ef6e025612 192 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 47 139 5.3E-18 T 09-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS08525 a96da7765999556dd538a1ef6e025612 192 Gene3D G3DSA:2.30.110.10 38 164 4.6E-31 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS08525 a96da7765999556dd538a1ef6e025612 192 TIGRFAM TIGR04025 PPOX_FMN_DR2398: pyridoxamine 5'-phosphate oxidase, FMN-binding family 25 183 9.2E-63 T 09-03-2017 IPR024029 Pyridoxamine 5-phosphate oxidase, FMN-dependent TK78_RS08525 a96da7765999556dd538a1ef6e025612 192 SUPERFAMILY SSF50475 46 165 1.27E-21 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS05425 2f7daf13661e8ce07dc5221d0b2743ba 133 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 5 122 2.5E-10 T 09-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain TK78_RS05425 2f7daf13661e8ce07dc5221d0b2743ba 133 Gene3D G3DSA:3.10.180.10 1 128 1.3E-31 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS05425 2f7daf13661e8ce07dc5221d0b2743ba 133 SUPERFAMILY SSF54593 1 131 1.3E-22 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS04380 732be7e571371d53080662991853e20d 134 Gene3D G3DSA:3.40.30.10 16 97 7.7E-8 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS04380 732be7e571371d53080662991853e20d 134 SUPERFAMILY SSF52833 15 100 3.24E-5 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS02495 6a332e8153fcedb9598cfbb45343eae6 316 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 24 182 1.0E-12 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS02495 6a332e8153fcedb9598cfbb45343eae6 316 SUPERFAMILY SSF54427 197 305 1.44E-13 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS02495 6a332e8153fcedb9598cfbb45343eae6 316 SUPERFAMILY SSF88946 22 102 9.02E-12 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS02495 6a332e8153fcedb9598cfbb45343eae6 316 Pfam PF08281 Sigma-70, region 4 130 180 4.3E-9 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS02495 6a332e8153fcedb9598cfbb45343eae6 316 SUPERFAMILY SSF88659 123 183 1.85E-9 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS02495 6a332e8153fcedb9598cfbb45343eae6 316 Gene3D G3DSA:1.10.1740.10 23 104 3.4E-10 T 09-03-2017 TK78_RS02495 6a332e8153fcedb9598cfbb45343eae6 316 Gene3D G3DSA:1.10.10.10 123 184 4.1E-9 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS02495 6a332e8153fcedb9598cfbb45343eae6 316 Pfam PF04542 Sigma-70 region 2 23 85 1.0E-10 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS02495 6a332e8153fcedb9598cfbb45343eae6 316 Gene3D G3DSA:3.10.450.50 195 305 2.0E-10 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS21805 720d10f63441923ac6d158981201eb9b 379 Gene3D G3DSA:3.40.50.20 4 110 2.2E-28 T 09-03-2017 IPR016185 Pre-ATP-grasp domain TK78_RS21805 720d10f63441923ac6d158981201eb9b 379 SUPERFAMILY SSF56059 102 300 2.47E-58 T 09-03-2017 TK78_RS21805 720d10f63441923ac6d158981201eb9b 379 Gene3D G3DSA:3.30.1490.20 121 178 6.7E-16 T 09-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 TK78_RS21805 720d10f63441923ac6d158981201eb9b 379 SUPERFAMILY SSF52440 4 97 2.45E-25 T 09-03-2017 IPR016185 Pre-ATP-grasp domain TK78_RS21805 720d10f63441923ac6d158981201eb9b 379 Hamap MF_01928 N5-carboxyaminoimidazole ribonucleotide synthase [purK]. 5 359 39.737 T 09-03-2017 IPR005875 Phosphoribosylaminoimidazole carboxylase, ATPase subunit GO:0004638|GO:0006189 TK78_RS21805 720d10f63441923ac6d158981201eb9b 379 SUPERFAMILY SSF51246 305 374 6.67E-17 T 09-03-2017 IPR011054 Rudiment single hybrid motif Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TK78_RS21805 720d10f63441923ac6d158981201eb9b 379 TIGRFAM TIGR01161 purK: phosphoribosylaminoimidazole carboxylase, ATPase subunit 6 364 3.3E-116 T 09-03-2017 IPR005875 Phosphoribosylaminoimidazole carboxylase, ATPase subunit GO:0004638|GO:0006189 TK78_RS21805 720d10f63441923ac6d158981201eb9b 379 Gene3D G3DSA:3.30.470.20 180 373 3.0E-68 T 09-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 TK78_RS21805 720d10f63441923ac6d158981201eb9b 379 Pfam PF02222 ATP-grasp domain 111 280 7.0E-49 T 09-03-2017 IPR003135 ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type TK78_RS30005 82294c6a34accf98ceadfc1a6e2c25b1 194 Gene3D G3DSA:1.10.3300.10 3 191 4.1E-56 T 09-03-2017 IPR023286 ABATE domain TK78_RS30005 82294c6a34accf98ceadfc1a6e2c25b1 194 Pfam PF07336 Putative stress-induced transcription regulator 13 135 1.8E-15 T 09-03-2017 IPR010852 Putative stress-induced transcription regulator TK78_RS30005 82294c6a34accf98ceadfc1a6e2c25b1 194 SUPERFAMILY SSF160904 2 188 3.01E-49 T 09-03-2017 TK78_RS30005 82294c6a34accf98ceadfc1a6e2c25b1 194 Pfam PF11706 CGNR zinc finger 146 189 1.1E-18 T 09-03-2017 IPR021005 Zinc finger, CGNR TK78_RS19700 29f9859afedbcd5b076e2e78a52d0e64 324 Gene3D G3DSA:3.40.190.120 164 259 4.5E-23 T 09-03-2017 TK78_RS19700 29f9859afedbcd5b076e2e78a52d0e64 324 SUPERFAMILY SSF53850 47 322 2.17E-43 T 09-03-2017 TK78_RS19700 29f9859afedbcd5b076e2e78a52d0e64 324 Pfam PF04069 Substrate binding domain of ABC-type glycine betaine transport system 48 317 2.4E-47 T 09-03-2017 IPR007210 ABC-type glycine betaine transport system, substrate-binding domain GO:0005215|GO:0006810 TK78_RS19700 29f9859afedbcd5b076e2e78a52d0e64 324 Gene3D G3DSA:3.40.190.10 272 323 1.7E-42 T 09-03-2017 TK78_RS19700 29f9859afedbcd5b076e2e78a52d0e64 324 Gene3D G3DSA:3.40.190.10 44 163 1.7E-42 T 09-03-2017 TK78_RS23730 99124b686139603aa03827dbdeeef5f4 310 Gene3D G3DSA:3.40.50.200 54 288 7.2E-45 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS23730 99124b686139603aa03827dbdeeef5f4 310 Pfam PF00082 Subtilase family 57 286 1.9E-20 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS23730 99124b686139603aa03827dbdeeef5f4 310 ProSitePatterns PS00136 Serine proteases, subtilase family, aspartic acid active site. 62 73 - T 09-03-2017 IPR023827 Peptidase S8, subtilisin, Asp-active site TK78_RS23730 99124b686139603aa03827dbdeeef5f4 310 PRINTS PR00723 Subtilisin serine protease family (S8) signature 248 264 4.2E-15 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS23730 99124b686139603aa03827dbdeeef5f4 310 PRINTS PR00723 Subtilisin serine protease family (S8) signature 57 76 4.2E-15 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS23730 99124b686139603aa03827dbdeeef5f4 310 PRINTS PR00723 Subtilisin serine protease family (S8) signature 103 116 4.2E-15 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS23730 99124b686139603aa03827dbdeeef5f4 310 SUPERFAMILY SSF52743 54 287 1.05E-50 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS18055 ea42fc4dc2f53c9aaf73ae5ccef989f3 196 Pfam PF07883 Cupin domain 42 110 8.0E-16 T 09-03-2017 IPR013096 Cupin 2, conserved barrel TK78_RS18055 ea42fc4dc2f53c9aaf73ae5ccef989f3 196 SUPERFAMILY SSF51182 18 122 5.57E-25 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS18055 ea42fc4dc2f53c9aaf73ae5ccef989f3 196 Gene3D G3DSA:2.60.120.10 21 163 6.1E-34 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS27055 56b7b6ff805b93fc4231f191b83e761f 187 SUPERFAMILY SSF53056 22 184 4.45E-32 T 09-03-2017 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 TK78_RS27055 56b7b6ff805b93fc4231f191b83e761f 187 Gene3D G3DSA:3.40.1050.10 25 184 1.5E-31 T 09-03-2017 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 TK78_RS27055 56b7b6ff805b93fc4231f191b83e761f 187 SMART SM00947 46 184 9.9E-22 T 09-03-2017 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 TK78_RS27055 56b7b6ff805b93fc4231f191b83e761f 187 Pfam PF00484 Carbonic anhydrase 54 121 3.8E-11 T 09-03-2017 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 TK78_RS01200 9616b519db00ed2e7d0678a7f69ebe8b 321 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 105 309 1.7E-15 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS01200 9616b519db00ed2e7d0678a7f69ebe8b 321 Gene3D G3DSA:1.10.3720.10 25 306 7.3E-54 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS01200 9616b519db00ed2e7d0678a7f69ebe8b 321 SUPERFAMILY SSF161098 74 303 2.35E-49 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS24085 6b6273db24d0a111b6aab058b6829a8b 1111 Pfam PF02687 FtsX-like permease family 980 1092 1.8E-13 T 09-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 TK78_RS24085 6b6273db24d0a111b6aab058b6829a8b 1111 Pfam PF02687 FtsX-like permease family 301 413 7.6E-7 T 09-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 TK78_RS09995 4b194e590e10f9f1dcbd219b4347e1cf 358 SMART SM00304 62 115 1.1E-13 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS09995 4b194e590e10f9f1dcbd219b4347e1cf 358 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 239 351 1.6E-21 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09995 4b194e590e10f9f1dcbd219b4347e1cf 358 PRINTS PR00344 Bacterial sensor protein C-terminal signature 277 291 1.1E-11 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS09995 4b194e590e10f9f1dcbd219b4347e1cf 358 PRINTS PR00344 Bacterial sensor protein C-terminal signature 315 333 1.1E-11 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS09995 4b194e590e10f9f1dcbd219b4347e1cf 358 PRINTS PR00344 Bacterial sensor protein C-terminal signature 338 351 1.1E-11 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS09995 4b194e590e10f9f1dcbd219b4347e1cf 358 Pfam PF00672 HAMP domain 45 111 7.1E-15 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS09995 4b194e590e10f9f1dcbd219b4347e1cf 358 SUPERFAMILY SSF47384 99 180 9.42E-18 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS09995 4b194e590e10f9f1dcbd219b4347e1cf 358 SMART SM00387 238 354 4.7E-34 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09995 4b194e590e10f9f1dcbd219b4347e1cf 358 Gene3D G3DSA:3.30.565.10 231 352 8.4E-38 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09995 4b194e590e10f9f1dcbd219b4347e1cf 358 Gene3D G3DSA:3.30.565.10 167 199 8.4E-38 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09995 4b194e590e10f9f1dcbd219b4347e1cf 358 SUPERFAMILY SSF158472 64 111 1.06E-10 T 09-03-2017 TK78_RS09995 4b194e590e10f9f1dcbd219b4347e1cf 358 SMART SM00388 116 180 6.0E-17 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS09995 4b194e590e10f9f1dcbd219b4347e1cf 358 Pfam PF00512 His Kinase A (phospho-acceptor) domain 117 180 1.1E-14 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS09995 4b194e590e10f9f1dcbd219b4347e1cf 358 SUPERFAMILY SSF55874 170 351 1.11E-35 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09995 4b194e590e10f9f1dcbd219b4347e1cf 358 Gene3D G3DSA:1.10.287.130 106 166 3.0E-16 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS21280 6bfde5d8592d8adf70e8763c5bb8f1b6 347 Gene3D G3DSA:3.30.428.10 181 345 5.8E-51 T 09-03-2017 IPR011146 HIT-like domain GO:0003824 TK78_RS21280 6bfde5d8592d8adf70e8763c5bb8f1b6 347 Pfam PF02744 Galactose-1-phosphate uridyl transferase, C-terminal domain 194 342 9.5E-17 T 09-03-2017 IPR005850 Galactose-1-phosphate uridyl transferase, C-terminal GO:0006012|GO:0008108 KEGG: 00052+2.7.7.12|KEGG: 00520+2.7.7.12|MetaCyc: PWY-6317|MetaCyc: PWY-6527|Reactome: R-HSA-5609978|Reactome: R-HSA-70370 TK78_RS21280 6bfde5d8592d8adf70e8763c5bb8f1b6 347 TIGRFAM TIGR00209 galT_1: galactose-1-phosphate uridylyltransferase 104 345 5.1E-42 T 09-03-2017 IPR001937 Galactose-1-phosphate uridyl transferase, class I GO:0006012|GO:0008108|GO:0008270 KEGG: 00052+2.7.7.12|KEGG: 00520+2.7.7.12|MetaCyc: PWY-6317|MetaCyc: PWY-6527|Reactome: R-HSA-5609978|Reactome: R-HSA-70370 TK78_RS21280 6bfde5d8592d8adf70e8763c5bb8f1b6 347 ProSitePatterns PS00117 Galactose-1-phosphate uridyl transferase family 1 active site signature. 154 171 - T 09-03-2017 IPR019779 Galactose-1-phosphate uridyl transferase, class I His-active site GO:0006012|GO:0008108|GO:0008270 KEGG: 00052+2.7.7.12|KEGG: 00520+2.7.7.12|MetaCyc: PWY-6317|MetaCyc: PWY-6527|Reactome: R-HSA-5609978|Reactome: R-HSA-70370 TK78_RS21280 6bfde5d8592d8adf70e8763c5bb8f1b6 347 SUPERFAMILY SSF54197 184 345 4.08E-36 T 09-03-2017 IPR011146 HIT-like domain GO:0003824 TK78_RS21280 6bfde5d8592d8adf70e8763c5bb8f1b6 347 Pfam PF01087 Galactose-1-phosphate uridyl transferase, N-terminal domain 102 178 3.7E-26 T 09-03-2017 IPR005849 Galactose-1-phosphate uridyl transferase, N-terminal GO:0006012|GO:0008108 KEGG: 00052+2.7.7.12|KEGG: 00520+2.7.7.12|MetaCyc: PWY-6317|MetaCyc: PWY-6527|Reactome: R-HSA-5609978|Reactome: R-HSA-70370 TK78_RS21280 6bfde5d8592d8adf70e8763c5bb8f1b6 347 PIRSF PIRSF000808 34 347 6.1E-107 T 09-03-2017 IPR001937 Galactose-1-phosphate uridyl transferase, class I GO:0006012|GO:0008108|GO:0008270 KEGG: 00052+2.7.7.12|KEGG: 00520+2.7.7.12|MetaCyc: PWY-6317|MetaCyc: PWY-6527|Reactome: R-HSA-5609978|Reactome: R-HSA-70370 TK78_RS21280 6bfde5d8592d8adf70e8763c5bb8f1b6 347 SUPERFAMILY SSF54197 37 179 3.25E-46 T 09-03-2017 IPR011146 HIT-like domain GO:0003824 TK78_RS21280 6bfde5d8592d8adf70e8763c5bb8f1b6 347 Gene3D G3DSA:3.30.428.10 64 178 5.1E-33 T 09-03-2017 IPR011146 HIT-like domain GO:0003824 TK78_RS01400 271ff5b7fcf1b4e646d761c01fe9a28d 497 SUPERFAMILY SSF47413 10 70 4.07E-7 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS01400 271ff5b7fcf1b4e646d761c01fe9a28d 497 Gene3D G3DSA:1.10.260.40 9 71 4.2E-8 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS01400 271ff5b7fcf1b4e646d761c01fe9a28d 497 Pfam PF13560 Helix-turn-helix domain 13 75 6.1E-13 T 09-03-2017 TK78_RS01400 271ff5b7fcf1b4e646d761c01fe9a28d 497 SMART SM00530 16 72 3.6E-7 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS07270 696e5011cb9791f50963e6fe96e8bffc 313 SMART SM00895 175 299 3.6E-20 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS07270 696e5011cb9791f50963e6fe96e8bffc 313 SUPERFAMILY SSF46785 79 150 1.94E-16 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS07270 696e5011cb9791f50963e6fe96e8bffc 313 Pfam PF07729 FCD domain 175 297 9.5E-22 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS07270 696e5011cb9791f50963e6fe96e8bffc 313 SMART SM00345 88 146 1.1E-11 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS07270 696e5011cb9791f50963e6fe96e8bffc 313 Gene3D G3DSA:1.20.120.530 172 297 7.4E-25 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS07270 696e5011cb9791f50963e6fe96e8bffc 313 Gene3D G3DSA:1.10.10.10 77 148 8.0E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS07270 696e5011cb9791f50963e6fe96e8bffc 313 Pfam PF00392 Bacterial regulatory proteins, gntR family 87 146 2.5E-14 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS07270 696e5011cb9791f50963e6fe96e8bffc 313 SUPERFAMILY SSF48008 172 298 2.01E-25 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS04215 6d6b7c0b4c3ed13bb92c30144d423cca 264 Gene3D G3DSA:3.40.630.30 123 256 5.8E-14 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS04215 6d6b7c0b4c3ed13bb92c30144d423cca 264 Pfam PF00583 Acetyltransferase (GNAT) family 180 250 7.9E-5 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS04215 6d6b7c0b4c3ed13bb92c30144d423cca 264 SUPERFAMILY SSF55729 40 258 9.07E-20 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS13935 8a3f99a45d59e6fe922ff09fd711d64e 199 Gene3D G3DSA:2.30.110.10 42 195 4.5E-59 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS13935 8a3f99a45d59e6fe922ff09fd711d64e 199 SUPERFAMILY SSF50475 44 197 6.38E-50 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS13935 8a3f99a45d59e6fe922ff09fd711d64e 199 Pfam PF01613 Flavin reductase like domain 53 195 3.8E-36 T 09-03-2017 IPR002563 Flavin reductase like domain GO:0010181 TK78_RS13935 8a3f99a45d59e6fe922ff09fd711d64e 199 SMART SM00903 52 196 1.8E-61 T 09-03-2017 IPR002563 Flavin reductase like domain GO:0010181 TK78_RS31580 62569c923b95067d2a83cc9bbc4bf4bf 157 Pfam PF00877 NlpC/P60 family 56 142 1.1E-25 T 09-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain TK78_RS31580 62569c923b95067d2a83cc9bbc4bf4bf 157 SUPERFAMILY SSF54001 43 154 2.6E-35 T 09-03-2017 TK78_RS31580 62569c923b95067d2a83cc9bbc4bf4bf 157 Gene3D G3DSA:3.90.1720.10 41 155 5.0E-39 T 09-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain TK78_RS28865 ac1e4d2fa32731f36bf0d6d22cff1779 754 TIGRFAM TIGR04267 mod_HExxH: HEXXH motif domain 383 681 1.9E-37 T 09-03-2017 IPR026337 HEXXH motif domain TK78_RS28865 ac1e4d2fa32731f36bf0d6d22cff1779 754 SUPERFAMILY SSF102114 8 333 6.15E-30 T 09-03-2017 TK78_RS28865 ac1e4d2fa32731f36bf0d6d22cff1779 754 Pfam PF04055 Radical SAM superfamily 12 163 5.1E-12 T 09-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 TK78_RS28865 ac1e4d2fa32731f36bf0d6d22cff1779 754 TIGRFAM TIGR04269 SAM_SPASM_FxsB: radical SAM/SPASM domain protein, FxsB family 4 368 9.5E-184 T 09-03-2017 IPR026335 Radical SAM/SPASM domain, FxsB family TK78_RS28865 ac1e4d2fa32731f36bf0d6d22cff1779 754 Gene3D G3DSA:3.20.20.70 6 340 1.5E-31 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS33090 aa687c68243f5bbc66f44db9b37b2a2d 138 SUPERFAMILY SSF55874 44 137 4.52E-10 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS33090 aa687c68243f5bbc66f44db9b37b2a2d 138 Gene3D G3DSA:3.30.565.10 50 137 1.9E-5 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS33090 aa687c68243f5bbc66f44db9b37b2a2d 138 Pfam PF13581 Histidine kinase-like ATPase domain 22 132 7.6E-11 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS31140 6cf4c676e06bd76f54d8833f11a52dc0 328 Pfam PF00196 Bacterial regulatory proteins, luxR family 268 311 9.7E-7 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS31140 6cf4c676e06bd76f54d8833f11a52dc0 328 Gene3D G3DSA:1.10.10.10 12 55 1.0E-4 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS31140 6cf4c676e06bd76f54d8833f11a52dc0 328 Gene3D G3DSA:1.10.10.10 268 317 9.2E-9 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS31140 6cf4c676e06bd76f54d8833f11a52dc0 328 SUPERFAMILY SSF46894 267 316 1.43E-7 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS31140 6cf4c676e06bd76f54d8833f11a52dc0 328 SMART SM00421 267 315 0.0065 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS15160 9b7610e502e79db12ee7cfda21a4468b 593 SUPERFAMILY SSF52540 349 591 1.84E-67 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15160 9b7610e502e79db12ee7cfda21a4468b 593 Pfam PF00664 ABC transporter transmembrane region 45 313 1.7E-24 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS15160 9b7610e502e79db12ee7cfda21a4468b 593 Gene3D G3DSA:3.40.50.300 356 585 7.1E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15160 9b7610e502e79db12ee7cfda21a4468b 593 Pfam PF00005 ABC transporter 372 521 5.7E-23 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS15160 9b7610e502e79db12ee7cfda21a4468b 593 SMART SM00382 381 567 1.3E-12 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS15160 9b7610e502e79db12ee7cfda21a4468b 593 Gene3D G3DSA:1.20.1560.10 34 336 3.4E-44 T 09-03-2017 TK78_RS15160 9b7610e502e79db12ee7cfda21a4468b 593 SUPERFAMILY SSF90123 33 339 8.11E-47 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS19500 5a23c8ee3863c7ac64962c7f10f82a52 563 Pfam PF00476 DNA polymerase family A 207 533 2.4E-26 T 09-03-2017 IPR001098 DNA-directed DNA polymerase, family A, palm domain GO:0003677|GO:0003887|GO:0006260 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS19500 5a23c8ee3863c7ac64962c7f10f82a52 563 SMART SM00482 312 522 6.3E-11 T 09-03-2017 IPR001098 DNA-directed DNA polymerase, family A, palm domain GO:0003677|GO:0003887|GO:0006260 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS19500 5a23c8ee3863c7ac64962c7f10f82a52 563 PRINTS PR00868 DNA-polymerase family A (pol I) signature 505 518 4.7E-7 T 09-03-2017 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS19500 5a23c8ee3863c7ac64962c7f10f82a52 563 PRINTS PR00868 DNA-polymerase family A (pol I) signature 475 491 4.7E-7 T 09-03-2017 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS19500 5a23c8ee3863c7ac64962c7f10f82a52 563 PRINTS PR00868 DNA-polymerase family A (pol I) signature 326 349 4.7E-7 T 09-03-2017 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS19500 5a23c8ee3863c7ac64962c7f10f82a52 563 Gene3D G3DSA:1.10.150.20 335 482 1.7E-16 T 09-03-2017 TK78_RS19500 5a23c8ee3863c7ac64962c7f10f82a52 563 SUPERFAMILY SSF56672 157 563 8.12E-64 T 09-03-2017 TK78_RS19500 5a23c8ee3863c7ac64962c7f10f82a52 563 Gene3D G3DSA:3.30.70.370 483 559 1.5E-11 T 09-03-2017 TK78_RS19500 5a23c8ee3863c7ac64962c7f10f82a52 563 Gene3D G3DSA:3.30.70.370 295 334 1.5E-11 T 09-03-2017 TK78_RS31080 73ea551603c009a039968f4170eb48cc 326 Pfam PF02780 Transketolase, C-terminal domain 199 308 2.2E-27 T 09-03-2017 IPR033248 Transketolase, C-terminal domain TK78_RS31080 73ea551603c009a039968f4170eb48cc 326 SUPERFAMILY SSF52922 194 325 2.88E-29 T 09-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 TK78_RS31080 73ea551603c009a039968f4170eb48cc 326 Gene3D G3DSA:3.40.50.920 200 321 4.4E-33 T 09-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 TK78_RS31080 73ea551603c009a039968f4170eb48cc 326 SMART SM00861 7 182 5.7E-53 T 09-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain TK78_RS31080 73ea551603c009a039968f4170eb48cc 326 Gene3D G3DSA:3.40.50.970 9 183 2.7E-56 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS31080 73ea551603c009a039968f4170eb48cc 326 Pfam PF02779 Transketolase, pyrimidine binding domain 10 180 1.7E-34 T 09-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain TK78_RS31080 73ea551603c009a039968f4170eb48cc 326 SUPERFAMILY SSF52518 9 184 1.71E-53 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS28520 606d83f16f04a1f134ff4d8be314ba11 169 Pfam PF14279 HNH endonuclease 84 134 3.5E-10 T 09-03-2017 IPR029471 HNH endonuclease 5 TK78_RS28520 606d83f16f04a1f134ff4d8be314ba11 169 SMART SM00507 71 120 4.1E-12 T 09-03-2017 IPR003615 HNH nuclease TK78_RS02000 21dbf976355eca2854ab0a75a69046d8 233 Pfam PF04029 2-phosphosulpholactate phosphatase 13 209 1.6E-31 T 09-03-2017 IPR005238 ComB-like GO:0000287|GO:0050532 KEGG: 00680+3.1.3.71 TK78_RS02000 21dbf976355eca2854ab0a75a69046d8 233 SUPERFAMILY SSF142823 8 211 2.35E-38 T 09-03-2017 IPR005238 ComB-like GO:0000287|GO:0050532 KEGG: 00680+3.1.3.71 TK78_RS02000 21dbf976355eca2854ab0a75a69046d8 233 Gene3D G3DSA:3.90.1560.10 8 214 1.9E-45 T 09-03-2017 IPR005238 ComB-like GO:0000287|GO:0050532 KEGG: 00680+3.1.3.71 TK78_RS19855 6bbf594a788a2622df9fd040812a99c0 374 Pfam PF10635 DisA bacterial checkpoint controller linker region 155 297 1.8E-52 T 09-03-2017 IPR018906 DNA integrity scanning, DisA, linker region TK78_RS19855 6bbf594a788a2622df9fd040812a99c0 374 Pfam PF12826 Helix-hairpin-helix motif 324 361 1.1E-6 T 09-03-2017 TK78_RS19855 6bbf594a788a2622df9fd040812a99c0 374 Pfam PF02457 DisA bacterial checkpoint controller nucleotide-binding 38 151 8.1E-23 T 09-03-2017 IPR003390 DNA integrity scanning protein, DisA, N-terminal TK78_RS19855 6bbf594a788a2622df9fd040812a99c0 374 Hamap MF_01438 DNA integrity scanning protein DisA [disA]. 16 371 43.434 T 09-03-2017 IPR023763 DNA integrity scanning protein, DisA TK78_RS19855 6bbf594a788a2622df9fd040812a99c0 374 SUPERFAMILY SSF47781 299 366 2.78E-12 T 09-03-2017 IPR010994 RuvA domain 2-like TK78_RS19855 6bbf594a788a2622df9fd040812a99c0 374 Gene3D G3DSA:3.40.1700.10 32 154 1.6E-29 T 09-03-2017 TK78_RS19855 6bbf594a788a2622df9fd040812a99c0 374 Gene3D G3DSA:1.10.150.20 311 361 5.5E-12 T 09-03-2017 TK78_RS19855 6bbf594a788a2622df9fd040812a99c0 374 SUPERFAMILY SSF143597 32 153 4.71E-26 T 09-03-2017 TK78_RS18205 7f9d11af1ff918b98803479f45265a83 484 Pfam PF07730 Histidine kinase 218 285 2.9E-14 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS18205 7f9d11af1ff918b98803479f45265a83 484 Gene3D G3DSA:3.30.565.10 305 397 3.5E-4 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS18205 7f9d11af1ff918b98803479f45265a83 484 SUPERFAMILY SSF55874 310 400 1.52E-9 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS17460 17ccf8726cffbcaec0138e430f4ec359 239 ProDom PD190647 REGULATORY RESISTANCE TRANSCRIPTION TRANSCRIPTIONAL ANTIBIOTIC DNA-BINDING ACTIVATOR REGULATION ORF699 NOSIHEPTIDE 1 227 3.0E-59 T 09-03-2017 TK78_RS17460 17ccf8726cffbcaec0138e430f4ec359 239 Gene3D G3DSA:1.20.120.20 16 137 1.2E-4 T 09-03-2017 TK78_RS22090 64d4fb0667b6c8b9795d2df96feeaa1b 678 SMART SM00304 284 336 5.1E-11 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS22090 64d4fb0667b6c8b9795d2df96feeaa1b 678 Gene3D G3DSA:3.30.565.10 414 569 2.4E-37 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS22090 64d4fb0667b6c8b9795d2df96feeaa1b 678 SUPERFAMILY SSF47384 327 411 2.35E-16 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS22090 64d4fb0667b6c8b9795d2df96feeaa1b 678 SMART SM00388 344 411 2.4E-16 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS22090 64d4fb0667b6c8b9795d2df96feeaa1b 678 Pfam PF00512 His Kinase A (phospho-acceptor) domain 344 411 2.0E-13 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS22090 64d4fb0667b6c8b9795d2df96feeaa1b 678 SUPERFAMILY SSF158472 284 332 1.57E-7 T 09-03-2017 TK78_RS22090 64d4fb0667b6c8b9795d2df96feeaa1b 678 Pfam PF00672 HAMP domain 265 332 9.5E-14 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS22090 64d4fb0667b6c8b9795d2df96feeaa1b 678 Gene3D G3DSA:1.10.287.130 335 407 3.3E-16 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS22090 64d4fb0667b6c8b9795d2df96feeaa1b 678 PRINTS PR00344 Bacterial sensor protein C-terminal signature 528 546 6.2E-14 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS22090 64d4fb0667b6c8b9795d2df96feeaa1b 678 PRINTS PR00344 Bacterial sensor protein C-terminal signature 552 565 6.2E-14 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS22090 64d4fb0667b6c8b9795d2df96feeaa1b 678 PRINTS PR00344 Bacterial sensor protein C-terminal signature 493 507 6.2E-14 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS22090 64d4fb0667b6c8b9795d2df96feeaa1b 678 PRINTS PR00344 Bacterial sensor protein C-terminal signature 511 521 6.2E-14 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS22090 64d4fb0667b6c8b9795d2df96feeaa1b 678 SMART SM00387 457 568 1.5E-28 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS22090 64d4fb0667b6c8b9795d2df96feeaa1b 678 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 458 567 2.0E-17 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS22090 64d4fb0667b6c8b9795d2df96feeaa1b 678 SUPERFAMILY SSF55874 401 570 5.37E-40 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS22125 c1957381234cf3a4dacee1a8c50ed9a0 939 Hamap MF_01382 Protein translocase subunit SecA [secA]. 3 841 19.993 T 09-03-2017 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 TK78_RS22125 c1957381234cf3a4dacee1a8c50ed9a0 939 Gene3D G3DSA:3.40.50.300 361 408 1.5E-122 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22125 c1957381234cf3a4dacee1a8c50ed9a0 939 Gene3D G3DSA:3.40.50.300 3 226 1.5E-122 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22125 c1957381234cf3a4dacee1a8c50ed9a0 939 Gene3D G3DSA:1.10.3060.10 655 839 4.3E-58 T 09-03-2017 IPR011116 SecA Wing/Scaffold GO:0016020|GO:0017038 TK78_RS22125 c1957381234cf3a4dacee1a8c50ed9a0 939 PRINTS PR00906 SecA protein signature 331 353 3.0E-72 T 09-03-2017 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 TK78_RS22125 c1957381234cf3a4dacee1a8c50ed9a0 939 PRINTS PR00906 SecA protein signature 115 125 3.0E-72 T 09-03-2017 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 TK78_RS22125 c1957381234cf3a4dacee1a8c50ed9a0 939 PRINTS PR00906 SecA protein signature 405 418 3.0E-72 T 09-03-2017 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 TK78_RS22125 c1957381234cf3a4dacee1a8c50ed9a0 939 PRINTS PR00906 SecA protein signature 99 113 3.0E-72 T 09-03-2017 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 TK78_RS22125 c1957381234cf3a4dacee1a8c50ed9a0 939 PRINTS PR00906 SecA protein signature 368 385 3.0E-72 T 09-03-2017 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 TK78_RS22125 c1957381234cf3a4dacee1a8c50ed9a0 939 PRINTS PR00906 SecA protein signature 61 85 3.0E-72 T 09-03-2017 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 TK78_RS22125 c1957381234cf3a4dacee1a8c50ed9a0 939 PRINTS PR00906 SecA protein signature 168 188 3.0E-72 T 09-03-2017 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 TK78_RS22125 c1957381234cf3a4dacee1a8c50ed9a0 939 TIGRFAM TIGR00963 secA: preprotein translocase, SecA subunit 26 827 0.0 T 09-03-2017 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 TK78_RS22125 c1957381234cf3a4dacee1a8c50ed9a0 939 ProSitePatterns PS01312 SecA family signature. 492 507 - T 09-03-2017 IPR020937 SecA conserved site GO:0006605|GO:0006886|GO:0016020 TK78_RS22125 c1957381234cf3a4dacee1a8c50ed9a0 939 Pfam PF01043 SecA preprotein cross-linking domain 232 350 6.7E-35 T 09-03-2017 IPR011130 SecA preprotein, cross-linking domain GO:0016020|GO:0017038 TK78_RS22125 c1957381234cf3a4dacee1a8c50ed9a0 939 Pfam PF07517 SecA DEAD-like domain 6 393 5.7E-129 T 09-03-2017 IPR011115 SecA DEAD-like, N-terminal GO:0005524|GO:0016020|GO:0017038 TK78_RS22125 c1957381234cf3a4dacee1a8c50ed9a0 939 SMART SM00957 4 394 3.1E-281 T 09-03-2017 IPR011115 SecA DEAD-like, N-terminal GO:0005524|GO:0016020|GO:0017038 TK78_RS22125 c1957381234cf3a4dacee1a8c50ed9a0 939 SUPERFAMILY SSF81767 225 360 3.53E-41 T 09-03-2017 IPR011130 SecA preprotein, cross-linking domain GO:0016020|GO:0017038 TK78_RS22125 c1957381234cf3a4dacee1a8c50ed9a0 939 Gene3D G3DSA:3.90.1440.10 228 360 6.8E-45 T 09-03-2017 IPR011130 SecA preprotein, cross-linking domain GO:0016020|GO:0017038 TK78_RS22125 c1957381234cf3a4dacee1a8c50ed9a0 939 SMART SM00958 226 350 2.2E-65 T 09-03-2017 IPR011130 SecA preprotein, cross-linking domain GO:0016020|GO:0017038 TK78_RS22125 c1957381234cf3a4dacee1a8c50ed9a0 939 SUPERFAMILY SSF81886 627 851 8.63E-74 T 09-03-2017 IPR011116 SecA Wing/Scaffold GO:0016020|GO:0017038 TK78_RS22125 c1957381234cf3a4dacee1a8c50ed9a0 939 SUPERFAMILY SSF52540 4 226 3.49E-81 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22125 c1957381234cf3a4dacee1a8c50ed9a0 939 SUPERFAMILY SSF52540 360 407 3.49E-81 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22125 c1957381234cf3a4dacee1a8c50ed9a0 939 Pfam PF07516 SecA Wing and Scaffold domain 624 838 3.2E-66 T 09-03-2017 IPR011116 SecA Wing/Scaffold GO:0016020|GO:0017038 TK78_RS22125 c1957381234cf3a4dacee1a8c50ed9a0 939 Gene3D G3DSA:3.40.50.300 409 626 1.0E-92 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22125 c1957381234cf3a4dacee1a8c50ed9a0 939 SUPERFAMILY SSF52540 408 625 2.08E-59 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS16250 f9f70ee6a1aeaaf137c0e6ef2882c11a 71 Pfam PF14117 Domain of unknown function (DUF4287) 8 64 7.2E-29 T 09-03-2017 IPR025629 Protein of unknown function DUF4287 TK78_RS14025 f6d6838e0fa35820c0a8cf5591391194 298 Gene3D G3DSA:3.40.50.170 102 296 6.3E-58 T 09-03-2017 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 TK78_RS14025 f6d6838e0fa35820c0a8cf5591391194 298 SUPERFAMILY SSF53328 102 297 6.15E-65 T 09-03-2017 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 TK78_RS14025 f6d6838e0fa35820c0a8cf5591391194 298 Pfam PF00551 Formyl transferase 102 279 8.1E-39 T 09-03-2017 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 TK78_RS14025 f6d6838e0fa35820c0a8cf5591391194 298 Hamap MF_01927 Formyltetrahydrofolate deformylase [purU]. 17 297 48.256 T 09-03-2017 IPR004810 Formyltetrahydrofolate deformylase GO:0006189|GO:0008864 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497 TK78_RS14025 f6d6838e0fa35820c0a8cf5591391194 298 Pfam PF13740 ACT domain 21 75 9.0E-6 T 09-03-2017 TK78_RS14025 f6d6838e0fa35820c0a8cf5591391194 298 SUPERFAMILY SSF55021 18 99 5.0E-20 T 09-03-2017 TK78_RS14025 f6d6838e0fa35820c0a8cf5591391194 298 PIRSF PIRSF036480 17 298 7.5E-116 T 09-03-2017 TK78_RS14025 f6d6838e0fa35820c0a8cf5591391194 298 PRINTS PR01575 Formyltetrahydrofolate deformylase signature 125 152 2.5E-52 T 09-03-2017 IPR004810 Formyltetrahydrofolate deformylase GO:0006189|GO:0008864 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497 TK78_RS14025 f6d6838e0fa35820c0a8cf5591391194 298 PRINTS PR01575 Formyltetrahydrofolate deformylase signature 54 66 2.5E-52 T 09-03-2017 IPR004810 Formyltetrahydrofolate deformylase GO:0006189|GO:0008864 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497 TK78_RS14025 f6d6838e0fa35820c0a8cf5591391194 298 PRINTS PR01575 Formyltetrahydrofolate deformylase signature 103 125 2.5E-52 T 09-03-2017 IPR004810 Formyltetrahydrofolate deformylase GO:0006189|GO:0008864 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497 TK78_RS14025 f6d6838e0fa35820c0a8cf5591391194 298 PRINTS PR01575 Formyltetrahydrofolate deformylase signature 249 271 2.5E-52 T 09-03-2017 IPR004810 Formyltetrahydrofolate deformylase GO:0006189|GO:0008864 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497 TK78_RS14025 f6d6838e0fa35820c0a8cf5591391194 298 PRINTS PR01575 Formyltetrahydrofolate deformylase signature 271 296 2.5E-52 T 09-03-2017 IPR004810 Formyltetrahydrofolate deformylase GO:0006189|GO:0008864 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497 TK78_RS14025 f6d6838e0fa35820c0a8cf5591391194 298 PRINTS PR01575 Formyltetrahydrofolate deformylase signature 22 48 2.5E-52 T 09-03-2017 IPR004810 Formyltetrahydrofolate deformylase GO:0006189|GO:0008864 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497 TK78_RS14025 f6d6838e0fa35820c0a8cf5591391194 298 TIGRFAM TIGR00655 PurU: formyltetrahydrofolate deformylase 21 297 3.9E-103 T 09-03-2017 IPR004810 Formyltetrahydrofolate deformylase GO:0006189|GO:0008864 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497 TK78_RS14025 f6d6838e0fa35820c0a8cf5591391194 298 Gene3D G3DSA:3.30.70.260 16 97 7.7E-31 T 09-03-2017 TK78_RS07120 59196d6c5fa8bf4e6600eee46f8cda56 298 SUPERFAMILY SSF48179 201 298 2.04E-28 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS07120 59196d6c5fa8bf4e6600eee46f8cda56 298 Gene3D G3DSA:3.40.50.720 19 202 2.2E-49 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07120 59196d6c5fa8bf4e6600eee46f8cda56 298 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 19 196 4.6E-52 T 09-03-2017 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS07120 59196d6c5fa8bf4e6600eee46f8cda56 298 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 201 297 1.2E-29 T 09-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS07120 59196d6c5fa8bf4e6600eee46f8cda56 298 PIRSF PIRSF000105 13 298 2.1E-72 T 09-03-2017 IPR022694 3-hydroxyacyl-CoA dehydrogenase GO:0003857|GO:0006631|GO:0055114|GO:0070403 TK78_RS07120 59196d6c5fa8bf4e6600eee46f8cda56 298 SUPERFAMILY SSF51735 17 197 8.31E-45 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07120 59196d6c5fa8bf4e6600eee46f8cda56 298 Gene3D G3DSA:1.10.1040.10 203 298 2.4E-30 T 09-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 TK78_RS28905 83a9cfbc40b5294a50fd1c890a9285d7 225 PIRSF PIRSF006171 1 225 2.9E-71 T 09-03-2017 IPR024187 Signal transduction response regulator, citrate/malate metabolism GO:0001071|GO:0003677|GO:0005737|GO:0009605 TK78_RS28905 83a9cfbc40b5294a50fd1c890a9285d7 225 SMART SM00448 1 118 2.1E-29 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS28905 83a9cfbc40b5294a50fd1c890a9285d7 225 Pfam PF00072 Response regulator receiver domain 1 118 1.1E-23 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS28905 83a9cfbc40b5294a50fd1c890a9285d7 225 SUPERFAMILY SSF52172 1 134 3.13E-35 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS28905 83a9cfbc40b5294a50fd1c890a9285d7 225 Gene3D G3DSA:3.40.50.2300 1 129 9.3E-33 T 09-03-2017 TK78_RS27450 1f9d6ec7a3ddcf17eb2652f72ef96819 260 SUPERFAMILY SSF51735 15 256 5.76E-71 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS27450 1f9d6ec7a3ddcf17eb2652f72ef96819 260 Gene3D G3DSA:3.40.50.720 11 255 1.8E-75 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS27450 1f9d6ec7a3ddcf17eb2652f72ef96819 260 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 148 156 7.8E-12 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS27450 1f9d6ec7a3ddcf17eb2652f72ef96819 260 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 168 187 7.8E-12 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS27450 1f9d6ec7a3ddcf17eb2652f72ef96819 260 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 94 105 7.8E-12 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS27450 1f9d6ec7a3ddcf17eb2652f72ef96819 260 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 155 183 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS27450 1f9d6ec7a3ddcf17eb2652f72ef96819 260 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 23 255 5.6E-62 T 09-03-2017 TK78_RS27450 1f9d6ec7a3ddcf17eb2652f72ef96819 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 142 158 6.5E-32 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS27450 1f9d6ec7a3ddcf17eb2652f72ef96819 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 18 35 6.5E-32 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS27450 1f9d6ec7a3ddcf17eb2652f72ef96819 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 94 105 6.5E-32 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS27450 1f9d6ec7a3ddcf17eb2652f72ef96819 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 168 187 6.5E-32 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS27450 1f9d6ec7a3ddcf17eb2652f72ef96819 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 223 243 6.5E-32 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS27450 1f9d6ec7a3ddcf17eb2652f72ef96819 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 189 206 6.5E-32 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 SMART SM00320 423 456 160.0 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 SMART SM00320 376 410 190.0 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 SMART SM00320 328 367 1.0 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 SMART SM00320 825 865 0.44 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 SMART SM00320 289 325 210.0 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 SMART SM00320 504 543 8.1E-6 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 SMART SM00320 462 498 4.9E-6 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 SMART SM00320 871 909 0.29 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 SMART SM00320 549 596 2.9E-5 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 Gene3D G3DSA:2.130.10.10 448 764 1.5E-51 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 SUPERFAMILY SSF52200 12 111 1.83E-10 T 09-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 PRINTS PR00320 G protein beta WD-40 repeat signature 485 499 8.3E-5 T 09-03-2017 IPR020472 G-protein beta WD-40 repeat TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 PRINTS PR00320 G protein beta WD-40 repeat signature 354 368 8.3E-5 T 09-03-2017 IPR020472 G-protein beta WD-40 repeat TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 PRINTS PR00320 G protein beta WD-40 repeat signature 530 544 8.3E-5 T 09-03-2017 IPR020472 G-protein beta WD-40 repeat TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 SUPERFAMILY SSF50998 305 598 2.28E-49 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 Gene3D G3DSA:2.130.10.10 765 937 1.3E-19 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 Pfam PF00400 WD domain, G-beta repeat 555 596 3.4E-6 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 Pfam PF00400 WD domain, G-beta repeat 512 543 0.0037 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 Pfam PF00400 WD domain, G-beta repeat 475 498 6.4E-5 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 Gene3D G3DSA:3.40.50.10140 13 104 3.0E-7 T 09-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 485 499 - T 09-03-2017 IPR019775 WD40 repeat, conserved site TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 SMART SM00255 15 164 0.0052 T 09-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 Gene3D G3DSA:2.130.10.10 297 447 4.5E-12 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 Pfam PF13676 TIR domain 18 124 1.0E-8 T 09-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 SUPERFAMILY SSF50978 643 674 3.3E-33 T 09-03-2017 IPR017986 WD40-repeat-containing domain GO:0005515 TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 SUPERFAMILY SSF50978 716 931 3.3E-33 T 09-03-2017 IPR017986 WD40-repeat-containing domain GO:0005515 TK78_RS06165 f16ba5621745b57aa6c88432f57d2b46 945 SUPERFAMILY SSF50978 555 603 3.3E-33 T 09-03-2017 IPR017986 WD40-repeat-containing domain GO:0005515 TK78_RS07540 31a2637d66ce128430937f72a53cc6e3 1561 SMART SM00490 291 412 1.7E-12 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS07540 31a2637d66ce128430937f72a53cc6e3 1561 Pfam PF00271 Helicase conserved C-terminal domain 346 412 9.9E-12 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS07540 31a2637d66ce128430937f72a53cc6e3 1561 Pfam PF08494 DEAD/H associated 676 896 1.2E-76 T 09-03-2017 IPR013701 DEAD/H associated GO:0005524|GO:0016818 TK78_RS07540 31a2637d66ce128430937f72a53cc6e3 1561 Pfam PF00270 DEAD/DEAH box helicase 25 208 4.8E-26 T 09-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 TK78_RS07540 31a2637d66ce128430937f72a53cc6e3 1561 SMART SM00487 20 239 1.8E-35 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS07540 31a2637d66ce128430937f72a53cc6e3 1561 SUPERFAMILY SSF52540 34 210 2.38E-47 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07540 31a2637d66ce128430937f72a53cc6e3 1561 SUPERFAMILY SSF52540 252 303 2.38E-47 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07540 31a2637d66ce128430937f72a53cc6e3 1561 SUPERFAMILY SSF52540 343 421 2.38E-47 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07540 31a2637d66ce128430937f72a53cc6e3 1561 Gene3D G3DSA:3.40.50.300 270 303 3.8E-28 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07540 31a2637d66ce128430937f72a53cc6e3 1561 Gene3D G3DSA:3.40.50.300 343 443 3.8E-28 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07540 31a2637d66ce128430937f72a53cc6e3 1561 Gene3D G3DSA:3.40.50.300 15 206 2.2E-43 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06375 317a5e3250d4f7e67a816e6cb0494f2c 386 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 114 205 3.5E-21 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS06375 317a5e3250d4f7e67a816e6cb0494f2c 386 Gene3D G3DSA:1.10.540.10 4 110 1.2E-16 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS06375 317a5e3250d4f7e67a816e6cb0494f2c 386 Gene3D G3DSA:1.20.140.10 208 369 8.4E-58 T 09-03-2017 TK78_RS06375 317a5e3250d4f7e67a816e6cb0494f2c 386 Gene3D G3DSA:2.40.110.10 113 207 3.5E-32 T 09-03-2017 TK78_RS06375 317a5e3250d4f7e67a816e6cb0494f2c 386 SUPERFAMILY SSF47203 216 368 9.67E-50 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS06375 317a5e3250d4f7e67a816e6cb0494f2c 386 SUPERFAMILY SSF56645 4 229 6.41E-55 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS06375 317a5e3250d4f7e67a816e6cb0494f2c 386 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 218 367 1.5E-48 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS06375 317a5e3250d4f7e67a816e6cb0494f2c 386 ProSitePatterns PS00072 Acyl-CoA dehydrogenases signature 1. 116 128 - T 09-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 TK78_RS06375 317a5e3250d4f7e67a816e6cb0494f2c 386 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 8 109 2.2E-12 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS01385 43017ccaae0ee6bb023c12256ca10d79 453 SUPERFAMILY SSF51971 4 215 7.53E-55 T 09-03-2017 TK78_RS01385 43017ccaae0ee6bb023c12256ca10d79 453 SUPERFAMILY SSF51971 264 321 7.53E-55 T 09-03-2017 TK78_RS01385 43017ccaae0ee6bb023c12256ca10d79 453 Gene3D G3DSA:3.50.50.60 100 320 1.7E-66 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS01385 43017ccaae0ee6bb023c12256ca10d79 453 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 6 173 3.4E-8 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS01385 43017ccaae0ee6bb023c12256ca10d79 453 PIRSF PIRSF000362 1 453 1.3E-163 T 09-03-2017 IPR021163 Ferredoxin-NADP+ reductase, adrenodoxin-type GO:0016491|GO:0055114 Reactome: R-HSA-196108|Reactome: R-HSA-211976|Reactome: R-HSA-2395516|Reactome: R-HSA-5579026 TK78_RS01385 43017ccaae0ee6bb023c12256ca10d79 453 Gene3D G3DSA:3.40.50.720 321 448 6.6E-74 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS01385 43017ccaae0ee6bb023c12256ca10d79 453 Gene3D G3DSA:3.40.50.720 5 99 6.6E-74 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS01385 43017ccaae0ee6bb023c12256ca10d79 453 PRINTS PR00419 Adrenodoxin reductase family signature 6 28 3.2E-13 T 09-03-2017 TK78_RS01385 43017ccaae0ee6bb023c12256ca10d79 453 PRINTS PR00419 Adrenodoxin reductase family signature 149 163 3.2E-13 T 09-03-2017 TK78_RS01385 43017ccaae0ee6bb023c12256ca10d79 453 SUPERFAMILY SSF51971 311 452 1.65E-6 T 09-03-2017 TK78_RS29090 3e372b19114cf7305272deab8a07f348 445 SUPERFAMILY SSF49785 337 445 4.53E-24 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS29090 3e372b19114cf7305272deab8a07f348 445 Gene3D G3DSA:3.40.630.10 48 321 6.3E-79 T 09-03-2017 TK78_RS29090 3e372b19114cf7305272deab8a07f348 445 Gene3D G3DSA:2.60.120.260 347 445 2.8E-15 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS29090 3e372b19114cf7305272deab8a07f348 445 SUPERFAMILY SSF53187 56 320 3.83E-71 T 09-03-2017 TK78_RS29090 3e372b19114cf7305272deab8a07f348 445 Pfam PF01483 Proprotein convertase P-domain 366 445 2.0E-19 T 09-03-2017 IPR002884 Proprotein convertase, P GO:0004252|GO:0006508 TK78_RS29090 3e372b19114cf7305272deab8a07f348 445 Pfam PF04389 Peptidase family M28 111 316 1.1E-47 T 09-03-2017 IPR007484 Peptidase M28 TK78_RS30060 944d8600b270c104414710d96c58b690 187 SUPERFAMILY SSF54197 22 179 4.4E-41 T 09-03-2017 IPR011146 HIT-like domain GO:0003824 TK78_RS30060 944d8600b270c104414710d96c58b690 187 Pfam PF01230 HIT domain 60 151 2.6E-10 T 09-03-2017 IPR001310 Histidine triad (HIT) protein TK78_RS30060 944d8600b270c104414710d96c58b690 187 Gene3D G3DSA:3.30.428.10 45 183 1.7E-38 T 09-03-2017 IPR011146 HIT-like domain GO:0003824 TK78_RS15925 975f7a7c8c50e00ebb78b745e8f074b7 295 SUPERFAMILY SSF111331 14 137 8.94E-8 T 09-03-2017 IPR016064 NAD kinase/diacylglycerol kinase-like domain TK78_RS29495 d32e63955b447f4fd298050165e1240f 271 SMART SM00422 1 71 1.4E-5 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS29495 d32e63955b447f4fd298050165e1240f 271 Pfam PF13411 MerR HTH family regulatory protein 2 70 1.1E-16 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS29495 d32e63955b447f4fd298050165e1240f 271 Gene3D G3DSA:1.10.1660.10 2 117 3.5E-18 T 09-03-2017 TK78_RS29495 d32e63955b447f4fd298050165e1240f 271 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 37 57 1.2E-6 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS29495 d32e63955b447f4fd298050165e1240f 271 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 2 13 1.2E-6 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS29495 d32e63955b447f4fd298050165e1240f 271 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 13 26 1.2E-6 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS29495 d32e63955b447f4fd298050165e1240f 271 SUPERFAMILY SSF46955 2 89 1.28E-15 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS04580 d39a0b69659aab85105d98c5432375d9 384 PIRSF PIRSF016578 1 382 9.2E-20 T 09-03-2017 TK78_RS04580 d39a0b69659aab85105d98c5432375d9 384 SUPERFAMILY SSF56645 6 243 9.29E-81 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS04580 d39a0b69659aab85105d98c5432375d9 384 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 124 217 4.3E-26 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS04580 d39a0b69659aab85105d98c5432375d9 384 Gene3D G3DSA:1.20.140.10 219 381 3.7E-60 T 09-03-2017 TK78_RS04580 d39a0b69659aab85105d98c5432375d9 384 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 230 379 9.0E-46 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS04580 d39a0b69659aab85105d98c5432375d9 384 SUPERFAMILY SSF47203 228 382 2.26E-51 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS04580 d39a0b69659aab85105d98c5432375d9 384 Gene3D G3DSA:2.40.110.10 124 218 7.5E-40 T 09-03-2017 TK78_RS04580 d39a0b69659aab85105d98c5432375d9 384 ProSitePatterns PS00072 Acyl-CoA dehydrogenases signature 1. 126 138 - T 09-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 TK78_RS04580 d39a0b69659aab85105d98c5432375d9 384 ProSitePatterns PS00073 Acyl-CoA dehydrogenases signature 2. 338 357 - T 09-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 TK78_RS04580 d39a0b69659aab85105d98c5432375d9 384 Gene3D G3DSA:1.10.540.10 7 120 1.9E-35 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS04580 d39a0b69659aab85105d98c5432375d9 384 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 9 120 2.3E-27 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS18090 2f177a34bf197615487edebe168164bf 208 Gene3D G3DSA:2.30.110.10 43 199 1.2E-45 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS18090 2f177a34bf197615487edebe168164bf 208 SMART SM00903 53 200 2.5E-45 T 09-03-2017 IPR002563 Flavin reductase like domain GO:0010181 TK78_RS18090 2f177a34bf197615487edebe168164bf 208 Pfam PF01613 Flavin reductase like domain 53 200 2.2E-33 T 09-03-2017 IPR002563 Flavin reductase like domain GO:0010181 TK78_RS18090 2f177a34bf197615487edebe168164bf 208 SUPERFAMILY SSF50475 48 200 8.34E-41 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 Gene3D G3DSA:1.20.1110.10 546 813 3.0E-55 T 09-03-2017 IPR023298 P-type ATPase, transmembrane domain Reactome: R-HSA-936837 TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 Gene3D G3DSA:1.20.1110.10 101 130 3.0E-55 T 09-03-2017 IPR023298 P-type ATPase, transmembrane domain Reactome: R-HSA-936837 TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 Gene3D G3DSA:2.70.150.10 44 79 5.1E-25 T 09-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 Gene3D G3DSA:2.70.150.10 131 231 5.1E-25 T 09-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 439 457 2.7E-8 T 09-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 608 633 2.7E-8 T 09-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 577 593 2.7E-8 T 09-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 107 355 2.5E-32 T 09-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 548 665 9.1E-28 T 09-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 Pfam PF00702 haloacid dehalogenase-like hydrolase 330 591 4.1E-19 T 09-03-2017 TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 SUPERFAMILY SSF81660 340 465 3.92E-8 T 09-03-2017 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 Reactome: R-HSA-936837 TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 Gene3D G3DSA:3.40.1110.10 379 460 1.2E-5 T 09-03-2017 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 Reactome: R-HSA-936837 TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 SUPERFAMILY SSF81653 138 230 1.83E-21 T 09-03-2017 TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 ProSitePatterns PS00154 E1-E2 ATPases phosphorylation site. 336 342 - T 09-03-2017 IPR018303 P-type ATPase, phosphorylation site Reactome: R-HSA-936837 TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 334 348 8.5E-22 T 09-03-2017 TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 499 509 8.5E-22 T 09-03-2017 TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 577 596 8.5E-22 T 09-03-2017 TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 183 197 8.5E-22 T 09-03-2017 TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 600 612 8.5E-22 T 09-03-2017 TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 Gene3D G3DSA:3.40.1110.10 324 352 8.6E-6 T 09-03-2017 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 Reactome: R-HSA-936837 TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 SUPERFAMILY SSF81665 44 136 7.85E-67 T 09-03-2017 TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 SUPERFAMILY SSF81665 234 328 7.85E-67 T 09-03-2017 TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 SUPERFAMILY SSF81665 626 821 7.85E-67 T 09-03-2017 TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 Pfam PF00122 E1-E2 ATPase 105 325 5.7E-50 T 09-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 SUPERFAMILY SSF56784 332 352 3.34E-36 T 09-03-2017 IPR023214 HAD-like domain TK78_RS14625 5a9175756c0ce3a79e5bdf4effe69591 823 SUPERFAMILY SSF56784 436 654 3.34E-36 T 09-03-2017 IPR023214 HAD-like domain TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 Gene3D G3DSA:3.30.70.250 701 762 4.5E-7 T 09-03-2017 TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 38 292 5.8E-90 T 09-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 SMART SM00823 Phosphopantetheine attachment site 1685 1757 8.3E-27 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 Gene3D G3DSA:3.40.47.10 36 304 7.5E-91 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 SUPERFAMILY SSF51735 1403 1620 1.03E-41 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 SUPERFAMILY SSF52151 764 860 7.06E-66 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 SUPERFAMILY SSF52151 572 700 7.06E-66 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 SMART SM00826 940 1105 7.6E-74 T 09-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1712 1727 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 Pfam PF14765 Polyketide synthase dehydratase 940 1215 2.4E-54 T 09-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 Gene3D G3DSA:1.10.1200.10 1692 1758 1.0E-20 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 576 873 3.5E-111 T 09-03-2017 IPR020801 Polyketide synthase, acyl transferase domain TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 Gene3D G3DSA:3.40.366.10 568 694 8.3E-72 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 Gene3D G3DSA:3.40.366.10 763 874 8.3E-72 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 SUPERFAMILY SSF47336 1678 1764 1.96E-20 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1404 1584 6.1E-57 T 09-03-2017 TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 SUPERFAMILY SSF55048 700 763 1.7E-11 T 09-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 Pfam PF00698 Acyl transferase domain 574 891 2.3E-83 T 09-03-2017 IPR014043 Acyl transferase TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 300 417 9.9E-45 T 09-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 420 528 6.7E-11 T 09-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 SUPERFAMILY SSF53901 34 159 1.44E-104 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 SUPERFAMILY SSF53901 188 417 1.44E-104 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 205 221 - T 09-03-2017 IPR018201 Beta-ketoacyl synthase, active site TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 Pfam PF08659 KR domain 1404 1582 6.9E-56 T 09-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 Pfam PF00550 Phosphopantetheine attachment site 1687 1753 5.4E-10 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 Gene3D G3DSA:3.40.47.10 305 471 1.1E-66 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 SMART SM00825 Beta-ketoacyl synthase 40 470 5.6E-224 T 09-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 SUPERFAMILY SSF51735 1223 1389 5.51E-24 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 SMART SM01294 1686 1753 1.1E-4 T 09-03-2017 TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 Gene3D G3DSA:3.40.50.720 1403 1585 7.5E-35 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31035 3b33a6d3df9ac39b7d794c456bee3f05 1836 Gene3D G3DSA:3.40.50.720 1681 1691 7.5E-35 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS24055 31c630ee0ea4017b42d2b050f8d45ca2 497 TIGRFAM TIGR01167 LPXTG_anchor: LPXTG cell wall anchor domain 457 491 8.9E-4 T 09-03-2017 IPR019931 LPXTG cell wall anchor domain TK78_RS24055 31c630ee0ea4017b42d2b050f8d45ca2 497 Pfam PF05506 Domain of unknown function (DUF756) 338 408 1.1E-9 T 09-03-2017 IPR008475 Bacterial phospholipase C, C-terminal domain GO:0004629|GO:0016042 KEGG: 00562+3.1.4.3|KEGG: 00564+3.1.4.3|KEGG: 00565+3.1.4.3 TK78_RS24055 31c630ee0ea4017b42d2b050f8d45ca2 497 TIGRFAM TIGR03934 TQXA_dom: TQXA domain 139 187 4.3E-16 T 09-03-2017 IPR023849 Uncharacterised domain CHP03934, TQXA TK78_RS06060 2235c5d047355b640a8dc03a4f026736 111 Hamap MF_00010 UPF0060 membrane protein YnfA [ynfA]. 4 109 20.383 T 09-03-2017 IPR003844 Uncharacterised protein family UPF0060 GO:0016020 TK78_RS06060 2235c5d047355b640a8dc03a4f026736 111 SUPERFAMILY SSF103481 10 109 9.81E-9 T 09-03-2017 TK78_RS06060 2235c5d047355b640a8dc03a4f026736 111 Pfam PF02694 Uncharacterised BCR, YnfA/UPF0060 family 4 110 4.3E-42 T 09-03-2017 IPR003844 Uncharacterised protein family UPF0060 GO:0016020 TK78_RS29035 63a9bc394866413079c64ac15103817a 383 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 6 118 2.1E-38 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS29035 63a9bc394866413079c64ac15103817a 383 ProSitePatterns PS00073 Acyl-CoA dehydrogenases signature 2. 336 355 - T 09-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 TK78_RS29035 63a9bc394866413079c64ac15103817a 383 Gene3D G3DSA:1.20.140.10 218 379 2.3E-66 T 09-03-2017 TK78_RS29035 63a9bc394866413079c64ac15103817a 383 Gene3D G3DSA:2.40.110.10 121 217 5.0E-40 T 09-03-2017 TK78_RS29035 63a9bc394866413079c64ac15103817a 383 Gene3D G3DSA:1.10.540.10 1 119 3.0E-43 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS29035 63a9bc394866413079c64ac15103817a 383 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 122 217 2.8E-29 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS29035 63a9bc394866413079c64ac15103817a 383 PIRSF PIRSF016578 3 380 6.1E-22 T 09-03-2017 TK78_RS29035 63a9bc394866413079c64ac15103817a 383 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 229 377 7.2E-49 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS29035 63a9bc394866413079c64ac15103817a 383 SUPERFAMILY SSF47203 228 379 3.54E-56 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS29035 63a9bc394866413079c64ac15103817a 383 SUPERFAMILY SSF56645 2 241 2.75E-89 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS14815 23dc27bf66813ebf68c0b6968927d70f 305 Pfam PF01418 Helix-turn-helix domain, rpiR family 20 90 5.0E-12 T 09-03-2017 IPR000281 Helix-turn-helix protein RpiR GO:0003700|GO:0006355 TK78_RS14815 23dc27bf66813ebf68c0b6968927d70f 305 Gene3D G3DSA:3.40.50.10490 117 284 2.8E-39 T 09-03-2017 TK78_RS14815 23dc27bf66813ebf68c0b6968927d70f 305 Gene3D G3DSA:1.10.10.10 20 93 7.5E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS14815 23dc27bf66813ebf68c0b6968927d70f 305 Pfam PF01380 SIS domain 149 275 2.0E-22 T 09-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 TK78_RS14815 23dc27bf66813ebf68c0b6968927d70f 305 SUPERFAMILY SSF53697 114 280 9.58E-38 T 09-03-2017 TK78_RS14815 23dc27bf66813ebf68c0b6968927d70f 305 SUPERFAMILY SSF46689 21 89 6.27E-14 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS22010 4bb9485f22e7d629bb71159514537e52 391 Pfam PF01238 Phosphomannose isomerase type I 3 357 1.1E-67 T 09-03-2017 IPR001250 Mannose-6-phosphate isomerase, type I GO:0004476|GO:0005975|GO:0008270 KEGG: 00051+5.3.1.8|KEGG: 00520+5.3.1.8|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5659|MetaCyc: PWY-6992|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882|Reactome: R-HSA-4043916|Reactome: R-HSA-446205 TK78_RS22010 4bb9485f22e7d629bb71159514537e52 391 PIRSF PIRSF001480 1 391 2.6E-94 T 09-03-2017 IPR016305 Mannose-6-phosphate isomerase GO:0004476|GO:0009298 KEGG: 00051+5.3.1.8|KEGG: 00520+5.3.1.8|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5659|MetaCyc: PWY-6992|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882|Reactome: R-HSA-4043916|Reactome: R-HSA-446205 TK78_RS22010 4bb9485f22e7d629bb71159514537e52 391 SUPERFAMILY SSF51182 2 387 2.2E-98 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS22010 4bb9485f22e7d629bb71159514537e52 391 Gene3D G3DSA:2.60.120.10 292 389 6.7E-15 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS22010 4bb9485f22e7d629bb71159514537e52 391 Gene3D G3DSA:1.10.441.10 144 235 2.5E-21 T 09-03-2017 TK78_RS22010 4bb9485f22e7d629bb71159514537e52 391 Gene3D G3DSA:1.10.441.10 278 291 2.5E-21 T 09-03-2017 TK78_RS22010 4bb9485f22e7d629bb71159514537e52 391 ProSitePatterns PS00965 Phosphomannose isomerase type I signature 1. 129 137 - T 09-03-2017 IPR018050 Phosphomannose isomerase, type I, conserved site GO:0004476 KEGG: 00051+5.3.1.8|KEGG: 00520+5.3.1.8|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5659|MetaCyc: PWY-6992|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882|Reactome: R-HSA-4043916|Reactome: R-HSA-446205 TK78_RS22010 4bb9485f22e7d629bb71159514537e52 391 PRINTS PR00714 Phosphomannose isomerase type I signature 4 22 5.0E-63 T 09-03-2017 IPR016305 Mannose-6-phosphate isomerase GO:0004476|GO:0009298 KEGG: 00051+5.3.1.8|KEGG: 00520+5.3.1.8|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5659|MetaCyc: PWY-6992|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882|Reactome: R-HSA-4043916|Reactome: R-HSA-446205 TK78_RS22010 4bb9485f22e7d629bb71159514537e52 391 PRINTS PR00714 Phosphomannose isomerase type I signature 240 259 5.0E-63 T 09-03-2017 IPR016305 Mannose-6-phosphate isomerase GO:0004476|GO:0009298 KEGG: 00051+5.3.1.8|KEGG: 00520+5.3.1.8|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5659|MetaCyc: PWY-6992|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882|Reactome: R-HSA-4043916|Reactome: R-HSA-446205 TK78_RS22010 4bb9485f22e7d629bb71159514537e52 391 PRINTS PR00714 Phosphomannose isomerase type I signature 224 239 5.0E-63 T 09-03-2017 IPR016305 Mannose-6-phosphate isomerase GO:0004476|GO:0009298 KEGG: 00051+5.3.1.8|KEGG: 00520+5.3.1.8|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5659|MetaCyc: PWY-6992|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882|Reactome: R-HSA-4043916|Reactome: R-HSA-446205 TK78_RS22010 4bb9485f22e7d629bb71159514537e52 391 PRINTS PR00714 Phosphomannose isomerase type I signature 259 278 5.0E-63 T 09-03-2017 IPR016305 Mannose-6-phosphate isomerase GO:0004476|GO:0009298 KEGG: 00051+5.3.1.8|KEGG: 00520+5.3.1.8|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5659|MetaCyc: PWY-6992|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882|Reactome: R-HSA-4043916|Reactome: R-HSA-446205 TK78_RS22010 4bb9485f22e7d629bb71159514537e52 391 PRINTS PR00714 Phosphomannose isomerase type I signature 31 46 5.0E-63 T 09-03-2017 IPR016305 Mannose-6-phosphate isomerase GO:0004476|GO:0009298 KEGG: 00051+5.3.1.8|KEGG: 00520+5.3.1.8|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5659|MetaCyc: PWY-6992|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882|Reactome: R-HSA-4043916|Reactome: R-HSA-446205 TK78_RS22010 4bb9485f22e7d629bb71159514537e52 391 PRINTS PR00714 Phosphomannose isomerase type I signature 84 105 5.0E-63 T 09-03-2017 IPR016305 Mannose-6-phosphate isomerase GO:0004476|GO:0009298 KEGG: 00051+5.3.1.8|KEGG: 00520+5.3.1.8|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5659|MetaCyc: PWY-6992|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882|Reactome: R-HSA-4043916|Reactome: R-HSA-446205 TK78_RS22010 4bb9485f22e7d629bb71159514537e52 391 PRINTS PR00714 Phosphomannose isomerase type I signature 278 297 5.0E-63 T 09-03-2017 IPR016305 Mannose-6-phosphate isomerase GO:0004476|GO:0009298 KEGG: 00051+5.3.1.8|KEGG: 00520+5.3.1.8|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5659|MetaCyc: PWY-6992|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882|Reactome: R-HSA-4043916|Reactome: R-HSA-446205 TK78_RS22010 4bb9485f22e7d629bb71159514537e52 391 PRINTS PR00714 Phosphomannose isomerase type I signature 129 152 5.0E-63 T 09-03-2017 IPR016305 Mannose-6-phosphate isomerase GO:0004476|GO:0009298 KEGG: 00051+5.3.1.8|KEGG: 00520+5.3.1.8|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5659|MetaCyc: PWY-6992|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882|Reactome: R-HSA-4043916|Reactome: R-HSA-446205 TK78_RS22010 4bb9485f22e7d629bb71159514537e52 391 TIGRFAM TIGR00218 manA: mannose-6-phosphate isomerase, class I 3 375 1.2E-71 T 09-03-2017 IPR001250 Mannose-6-phosphate isomerase, type I GO:0004476|GO:0005975|GO:0008270 KEGG: 00051+5.3.1.8|KEGG: 00520+5.3.1.8|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5659|MetaCyc: PWY-6992|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882|Reactome: R-HSA-4043916|Reactome: R-HSA-446205 TK78_RS22010 4bb9485f22e7d629bb71159514537e52 391 Gene3D G3DSA:2.60.120.10 242 277 1.8E-59 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS22010 4bb9485f22e7d629bb71159514537e52 391 Gene3D G3DSA:2.60.120.10 6 143 1.8E-59 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS18420 fd0d75bb22b0d50cb76509fc9cc1583c 248 Gene3D G3DSA:1.10.490.50 156 245 5.9E-32 T 09-03-2017 IPR012925 TipAS antibiotic-recognition domain TK78_RS18420 fd0d75bb22b0d50cb76509fc9cc1583c 248 Gene3D G3DSA:1.10.1660.10 2 58 1.5E-22 T 09-03-2017 TK78_RS18420 fd0d75bb22b0d50cb76509fc9cc1583c 248 SUPERFAMILY SSF89082 157 243 1.44E-24 T 09-03-2017 IPR012925 TipAS antibiotic-recognition domain TK78_RS18420 fd0d75bb22b0d50cb76509fc9cc1583c 248 SMART SM00422 3 72 8.8E-19 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS18420 fd0d75bb22b0d50cb76509fc9cc1583c 248 Gene3D G3DSA:1.10.1660.10 59 104 1.4E-6 T 09-03-2017 TK78_RS18420 fd0d75bb22b0d50cb76509fc9cc1583c 248 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 4 15 4.0E-5 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS18420 fd0d75bb22b0d50cb76509fc9cc1583c 248 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 39 59 4.0E-5 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS18420 fd0d75bb22b0d50cb76509fc9cc1583c 248 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 15 28 4.0E-5 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS18420 fd0d75bb22b0d50cb76509fc9cc1583c 248 Pfam PF13411 MerR HTH family regulatory protein 4 71 3.1E-18 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS18420 fd0d75bb22b0d50cb76509fc9cc1583c 248 SUPERFAMILY SSF46955 3 106 2.71E-25 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS18420 fd0d75bb22b0d50cb76509fc9cc1583c 248 Pfam PF07739 TipAS antibiotic-recognition domain 127 241 2.6E-34 T 09-03-2017 IPR012925 TipAS antibiotic-recognition domain TK78_RS32805 13639307cfc536f72e02d4129b72178f 376 Gene3D G3DSA:1.20.1250.20 2 179 1.4E-14 T 09-03-2017 TK78_RS32805 13639307cfc536f72e02d4129b72178f 376 Gene3D G3DSA:1.20.1250.20 198 368 2.5E-18 T 09-03-2017 TK78_RS32805 13639307cfc536f72e02d4129b72178f 376 SUPERFAMILY SSF103473 2 368 2.62E-39 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS32805 13639307cfc536f72e02d4129b72178f 376 Pfam PF07690 Major Facilitator Superfamily 11 196 4.1E-14 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS32805 13639307cfc536f72e02d4129b72178f 376 Pfam PF07690 Major Facilitator Superfamily 206 367 1.4E-9 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS04795 ca6baf9a06243fe8f85c1938ddc58b99 436 SUPERFAMILY SSF48576 116 424 2.68E-37 T 09-03-2017 IPR008949 Isoprenoid synthase domain TK78_RS04795 ca6baf9a06243fe8f85c1938ddc58b99 436 Gene3D G3DSA:1.10.600.10 115 431 8.5E-66 T 09-03-2017 IPR008949 Isoprenoid synthase domain TK78_RS08700 86de8a6f7ee4c4edf52b95104c7c8e06 185 Pfam PF13527 Acetyltransferase (GNAT) domain 17 135 7.8E-11 T 09-03-2017 TK78_RS08700 86de8a6f7ee4c4edf52b95104c7c8e06 185 SUPERFAMILY SSF55729 17 183 1.12E-25 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS08700 86de8a6f7ee4c4edf52b95104c7c8e06 185 Gene3D G3DSA:3.40.630.30 7 184 2.2E-52 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS33645 26c7aee572e79fe2c9151d772e3fa89b 368 SUPERFAMILY SSF55874 204 367 2.36E-37 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS33645 26c7aee572e79fe2c9151d772e3fa89b 368 Gene3D G3DSA:1.10.287.130 142 210 7.9E-19 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS33645 26c7aee572e79fe2c9151d772e3fa89b 368 Gene3D G3DSA:3.30.565.10 216 367 4.9E-37 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS33645 26c7aee572e79fe2c9151d772e3fa89b 368 Pfam PF00512 His Kinase A (phospho-acceptor) domain 150 214 3.3E-16 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS33645 26c7aee572e79fe2c9151d772e3fa89b 368 SUPERFAMILY SSF47384 138 215 3.92E-17 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS33645 26c7aee572e79fe2c9151d772e3fa89b 368 SMART SM00388 150 214 2.3E-18 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS33645 26c7aee572e79fe2c9151d772e3fa89b 368 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 262 367 2.3E-16 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS33645 26c7aee572e79fe2c9151d772e3fa89b 368 SMART SM00387 259 368 1.4E-24 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS33645 26c7aee572e79fe2c9151d772e3fa89b 368 PRINTS PR00344 Bacterial sensor protein C-terminal signature 353 366 3.5E-10 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS33645 26c7aee572e79fe2c9151d772e3fa89b 368 PRINTS PR00344 Bacterial sensor protein C-terminal signature 296 310 3.5E-10 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS33645 26c7aee572e79fe2c9151d772e3fa89b 368 PRINTS PR00344 Bacterial sensor protein C-terminal signature 330 348 3.5E-10 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS28405 31f401a34cd029a9c2574a1d12bba433 423 TIGRFAM TIGR00234 tyrS: tyrosine--tRNA ligase 2 419 4.0E-114 T 09-03-2017 IPR002307 Tyrosine-tRNA ligase GO:0000166|GO:0004831|GO:0005524|GO:0005737|GO:0006437 KEGG: 00970+6.1.1.1 TK78_RS28405 31f401a34cd029a9c2574a1d12bba433 423 Gene3D G3DSA:3.40.50.620 2 233 2.9E-96 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS28405 31f401a34cd029a9c2574a1d12bba433 423 Pfam PF00579 tRNA synthetases class I (W and Y) 30 324 3.7E-79 T 09-03-2017 IPR002305 Aminoacyl-tRNA synthetase, class Ic GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS28405 31f401a34cd029a9c2574a1d12bba433 423 PRINTS PR01040 Tyrosyl-tRNA synthetase signature 44 66 2.7E-26 T 09-03-2017 IPR002307 Tyrosine-tRNA ligase GO:0000166|GO:0004831|GO:0005524|GO:0005737|GO:0006437 KEGG: 00970+6.1.1.1 TK78_RS28405 31f401a34cd029a9c2574a1d12bba433 423 PRINTS PR01040 Tyrosyl-tRNA synthetase signature 183 205 2.7E-26 T 09-03-2017 IPR002307 Tyrosine-tRNA ligase GO:0000166|GO:0004831|GO:0005524|GO:0005737|GO:0006437 KEGG: 00970+6.1.1.1 TK78_RS28405 31f401a34cd029a9c2574a1d12bba433 423 PRINTS PR01040 Tyrosyl-tRNA synthetase signature 162 177 2.7E-26 T 09-03-2017 IPR002307 Tyrosine-tRNA ligase GO:0000166|GO:0004831|GO:0005524|GO:0005737|GO:0006437 KEGG: 00970+6.1.1.1 TK78_RS28405 31f401a34cd029a9c2574a1d12bba433 423 PRINTS PR01040 Tyrosyl-tRNA synthetase signature 217 229 2.7E-26 T 09-03-2017 IPR002307 Tyrosine-tRNA ligase GO:0000166|GO:0004831|GO:0005524|GO:0005737|GO:0006437 KEGG: 00970+6.1.1.1 TK78_RS28405 31f401a34cd029a9c2574a1d12bba433 423 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 40 50 - T 09-03-2017 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS28405 31f401a34cd029a9c2574a1d12bba433 423 Gene3D G3DSA:1.10.240.10 234 317 4.5E-40 T 09-03-2017 TK78_RS28405 31f401a34cd029a9c2574a1d12bba433 423 SUPERFAMILY SSF55174 327 418 8.54E-17 T 09-03-2017 TK78_RS28405 31f401a34cd029a9c2574a1d12bba433 423 SMART SM00363 353 415 1.0E-4 T 09-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 TK78_RS28405 31f401a34cd029a9c2574a1d12bba433 423 SUPERFAMILY SSF52374 3 324 6.61E-101 T 09-03-2017 TK78_RS28405 31f401a34cd029a9c2574a1d12bba433 423 Hamap MF_02006 Tyrosine--tRNA ligase [tyrS]. 2 419 44.428 T 09-03-2017 IPR024107 Tyrosine-tRNA ligase, bacterial-type, type 1 GO:0004831 KEGG: 00970+6.1.1.1 TK78_RS28405 31f401a34cd029a9c2574a1d12bba433 423 Gene3D G3DSA:3.10.290.10 318 419 2.5E-29 T 09-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 TK78_RS00965 fb5f787a83206f66ae9afd20e9fc9e33 142 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 7 93 3.0E-19 T 09-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS00965 fb5f787a83206f66ae9afd20e9fc9e33 142 TIGRFAM TIGR03618 Rv1155_F420: PPOX class probable F420-dependent enzyme 10 135 2.1E-42 T 09-03-2017 IPR019920 F420-binding domain, putative TK78_RS00965 fb5f787a83206f66ae9afd20e9fc9e33 142 SUPERFAMILY SSF50475 3 136 1.8E-33 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS00965 fb5f787a83206f66ae9afd20e9fc9e33 142 Gene3D G3DSA:2.30.110.10 4 138 6.2E-43 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS25810 53c1a65b97dbb54fe62a72550454d476 353 Pfam PF00753 Metallo-beta-lactamase superfamily 32 263 4.8E-17 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS25810 53c1a65b97dbb54fe62a72550454d476 353 Gene3D G3DSA:3.60.15.10 15 132 2.0E-45 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS25810 53c1a65b97dbb54fe62a72550454d476 353 Gene3D G3DSA:3.60.15.10 164 306 2.0E-45 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS25810 53c1a65b97dbb54fe62a72550454d476 353 SMART SM00849 33 263 8.0E-23 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS25810 53c1a65b97dbb54fe62a72550454d476 353 SUPERFAMILY SSF56281 10 347 1.44E-54 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS07200 dc365e45807eb213b27c62f2d59165bf 457 SUPERFAMILY SSF63411 251 441 7.67E-27 T 09-03-2017 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 TK78_RS07200 dc365e45807eb213b27c62f2d59165bf 457 Gene3D G3DSA:3.30.830.10 277 430 3.8E-16 T 09-03-2017 IPR011237 Peptidase M16 domain GO:0046872 TK78_RS07200 dc365e45807eb213b27c62f2d59165bf 457 Pfam PF05193 Peptidase M16 inactive domain 187 366 1.5E-29 T 09-03-2017 IPR007863 Peptidase M16, C-terminal TK78_RS07200 dc365e45807eb213b27c62f2d59165bf 457 Pfam PF00675 Insulinase (Peptidase family M16) 28 147 1.1E-20 T 09-03-2017 IPR011765 Peptidase M16, N-terminal TK78_RS07200 dc365e45807eb213b27c62f2d59165bf 457 Gene3D G3DSA:3.30.830.10 21 238 1.4E-60 T 09-03-2017 IPR011237 Peptidase M16 domain GO:0046872 TK78_RS07200 dc365e45807eb213b27c62f2d59165bf 457 SUPERFAMILY SSF63411 19 225 7.52E-60 T 09-03-2017 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 TK78_RS20885 b9795860ff0318793826540ea9eaf5a4 914 Gene3D G3DSA:2.30.120.10 392 474 8.2E-25 T 09-03-2017 TK78_RS20885 b9795860ff0318793826540ea9eaf5a4 914 SUPERFAMILY SSF56235 66 260 3.09E-219 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS20885 b9795860ff0318793826540ea9eaf5a4 914 SUPERFAMILY SSF56235 298 914 3.09E-219 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS20885 b9795860ff0318793826540ea9eaf5a4 914 PIRSF PIRSF001227 28 914 2.0E-273 T 09-03-2017 IPR014395 Penicillin acylase GO:0016811 TK78_RS20885 b9795860ff0318793826540ea9eaf5a4 914 Pfam PF01804 Penicillin amidase 70 903 6.4E-245 T 09-03-2017 IPR002692 Penicillin/cephalosporin acylase GO:0016787|GO:0017000 TK78_RS20885 b9795860ff0318793826540ea9eaf5a4 914 Gene3D G3DSA:1.10.439.10 55 231 6.8E-62 T 09-03-2017 IPR023343 Penicillin amidase type, domain1 GO:0016811 TK78_RS20885 b9795860ff0318793826540ea9eaf5a4 914 Gene3D G3DSA:3.60.20.10 483 690 1.0E-114 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS20885 b9795860ff0318793826540ea9eaf5a4 914 Gene3D G3DSA:3.60.20.10 310 391 1.0E-114 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS20885 b9795860ff0318793826540ea9eaf5a4 914 Gene3D G3DSA:3.60.20.10 735 752 1.0E-114 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS21300 33e7184831fbb1410a1125418a750a89 262 Pfam PF00072 Response regulator receiver domain 86 141 2.4E-5 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS21300 33e7184831fbb1410a1125418a750a89 262 Pfam PF00072 Response regulator receiver domain 6 68 1.2E-5 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS21300 33e7184831fbb1410a1125418a750a89 262 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 194 210 9.8E-12 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS21300 33e7184831fbb1410a1125418a750a89 262 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 180 194 9.8E-12 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS21300 33e7184831fbb1410a1125418a750a89 262 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 210 222 9.8E-12 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS21300 33e7184831fbb1410a1125418a750a89 262 SMART SM00448 4 141 1.1E-15 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS21300 33e7184831fbb1410a1125418a750a89 262 Gene3D G3DSA:1.10.10.10 179 239 1.2E-24 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS21300 33e7184831fbb1410a1125418a750a89 262 SMART SM00421 177 234 2.1E-20 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS21300 33e7184831fbb1410a1125418a750a89 262 SUPERFAMILY SSF52172 3 160 8.54E-17 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS21300 33e7184831fbb1410a1125418a750a89 262 Pfam PF00196 Bacterial regulatory proteins, luxR family 179 234 9.4E-19 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS21300 33e7184831fbb1410a1125418a750a89 262 Gene3D G3DSA:3.40.50.2300 3 178 5.6E-37 T 09-03-2017 TK78_RS21300 33e7184831fbb1410a1125418a750a89 262 SUPERFAMILY SSF46894 170 239 3.74E-20 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS32225 5e3d251416df1f0822a791f4a4ee6d31 194 SUPERFAMILY SSF46689 12 83 4.09E-12 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS32225 5e3d251416df1f0822a791f4a4ee6d31 194 SUPERFAMILY SSF48498 86 190 3.17E-12 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS32225 5e3d251416df1f0822a791f4a4ee6d31 194 Pfam PF00440 Bacterial regulatory proteins, tetR family 38 66 2.3E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS32225 5e3d251416df1f0822a791f4a4ee6d31 194 Gene3D G3DSA:1.10.357.10 11 191 2.5E-36 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS23240 4f061e8236f30e9c86e75fe5c605dd52 262 SUPERFAMILY SSF46894 4 94 1.02E-11 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS23240 4f061e8236f30e9c86e75fe5c605dd52 262 Pfam PF00486 Transcriptional regulatory protein, C terminal 22 94 1.2E-8 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS23240 4f061e8236f30e9c86e75fe5c605dd52 262 Gene3D G3DSA:1.10.10.10 22 96 3.6E-9 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS23240 4f061e8236f30e9c86e75fe5c605dd52 262 Pfam PF03704 Bacterial transcriptional activator domain 102 246 8.7E-40 T 09-03-2017 IPR005158 Bacterial transcriptional activator domain TK78_RS23240 4f061e8236f30e9c86e75fe5c605dd52 262 SMART SM01043 101 246 4.4E-39 T 09-03-2017 IPR005158 Bacterial transcriptional activator domain TK78_RS23240 4f061e8236f30e9c86e75fe5c605dd52 262 SMART SM00862 13 94 2.3E-4 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS23240 4f061e8236f30e9c86e75fe5c605dd52 262 SUPERFAMILY SSF48452 96 260 1.86E-35 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS24710 37fda56f7d32121692e2878c854e5357 658 Gene3D G3DSA:3.30.450.40 227 395 3.9E-4 T 09-03-2017 IPR029016 GAF domain-like TK78_RS24710 37fda56f7d32121692e2878c854e5357 658 Pfam PF13581 Histidine kinase-like ATPase domain 43 173 2.7E-7 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS24710 37fda56f7d32121692e2878c854e5357 658 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 443 656 5.1E-42 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS24710 37fda56f7d32121692e2878c854e5357 658 SMART SM00331 418 657 4.5E-42 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS24710 37fda56f7d32121692e2878c854e5357 658 SUPERFAMILY SSF81606 432 655 4.97E-7 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS10275 0c5d84d70c6d8bac0702c4cf7e14031c 261 Gene3D G3DSA:3.40.50.1360 2 251 1.2E-88 T 09-03-2017 TK78_RS10275 0c5d84d70c6d8bac0702c4cf7e14031c 261 ProSitePatterns PS01161 Glucosamine/galactosamine-6-phosphate isomerases signature. 120 138 - T 09-03-2017 IPR018321 Glucosamine-6-phosphate isomerase, conserved site GO:0004342|GO:0006044 KEGG: 00520+3.5.99.6|MetaCyc: PWY-5514|MetaCyc: PWY-6855|MetaCyc: PWY-6906|Reactome: R-HSA-70326 TK78_RS10275 0c5d84d70c6d8bac0702c4cf7e14031c 261 Hamap MF_01241 Glucosamine-6-phosphate deaminase [nagB]. 1 242 38.503 T 09-03-2017 IPR004547 Glucosamine-6-phosphate isomerase GO:0004342|GO:0006044 KEGG: 00520+3.5.99.6|MetaCyc: PWY-5514|MetaCyc: PWY-6855|MetaCyc: PWY-6906|Reactome: R-HSA-70326 TK78_RS10275 0c5d84d70c6d8bac0702c4cf7e14031c 261 SUPERFAMILY SSF100950 2 252 2.63E-85 T 09-03-2017 TK78_RS10275 0c5d84d70c6d8bac0702c4cf7e14031c 261 TIGRFAM TIGR00502 nagB: glucosamine-6-phosphate deaminase 15 245 7.2E-75 T 09-03-2017 IPR004547 Glucosamine-6-phosphate isomerase GO:0004342|GO:0006044 KEGG: 00520+3.5.99.6|MetaCyc: PWY-5514|MetaCyc: PWY-6855|MetaCyc: PWY-6906|Reactome: R-HSA-70326 TK78_RS10275 0c5d84d70c6d8bac0702c4cf7e14031c 261 Pfam PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 10 227 1.2E-23 T 09-03-2017 IPR006148 Glucosamine/galactosamine-6-phosphate isomerase GO:0005975 KEGG: 00520+3.5.99.6|MetaCyc: PWY-5514|MetaCyc: PWY-6855|MetaCyc: PWY-6906 TK78_RS02975 9d24653a2ce5997bda49be3a74ae05aa 339 SUPERFAMILY SSF53850 37 263 9.67E-36 T 09-03-2017 TK78_RS02975 9d24653a2ce5997bda49be3a74ae05aa 339 Pfam PF09084 NMT1/THI5 like 50 262 3.5E-42 T 09-03-2017 IPR015168 SsuA/THI5-like TK78_RS02975 9d24653a2ce5997bda49be3a74ae05aa 339 Gene3D G3DSA:3.40.190.10 130 247 3.4E-12 T 09-03-2017 TK78_RS04800 949b39d38db9c4b1c316591b93dd5801 470 Gene3D G3DSA:2.60.120.10 103 223 1.7E-18 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS04800 949b39d38db9c4b1c316591b93dd5801 470 SMART SM00100 95 218 3.0E-13 T 09-03-2017 IPR000595 Cyclic nucleotide-binding domain TK78_RS04800 949b39d38db9c4b1c316591b93dd5801 470 Pfam PF00027 Cyclic nucleotide-binding domain 115 202 8.2E-16 T 09-03-2017 IPR000595 Cyclic nucleotide-binding domain TK78_RS04800 949b39d38db9c4b1c316591b93dd5801 470 SUPERFAMILY SSF51206 88 224 1.83E-21 T 09-03-2017 IPR018490 Cyclic nucleotide-binding-like TK78_RS03750 4c6e9e8ff1a160320eaa948ec5b43f4e 735 Gene3D G3DSA:1.25.40.10 521 648 3.1E-7 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS03750 4c6e9e8ff1a160320eaa948ec5b43f4e 735 SUPERFAMILY SSF52540 53 272 2.43E-17 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03750 4c6e9e8ff1a160320eaa948ec5b43f4e 735 PRINTS PR00364 Disease resistance protein signature 164 178 2.4E-5 T 09-03-2017 TK78_RS03750 4c6e9e8ff1a160320eaa948ec5b43f4e 735 PRINTS PR00364 Disease resistance protein signature 85 100 2.4E-5 T 09-03-2017 TK78_RS03750 4c6e9e8ff1a160320eaa948ec5b43f4e 735 PRINTS PR00364 Disease resistance protein signature 245 259 2.4E-5 T 09-03-2017 TK78_RS03750 4c6e9e8ff1a160320eaa948ec5b43f4e 735 SUPERFAMILY SSF48452 521 687 1.46E-9 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS03750 4c6e9e8ff1a160320eaa948ec5b43f4e 735 Gene3D G3DSA:3.40.50.300 57 104 4.4E-4 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06960 7cbba464ab9a0d44571d95b5eab03e30 276 SUPERFAMILY SSF52821 146 274 1.31E-27 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS06960 7cbba464ab9a0d44571d95b5eab03e30 276 ProSitePatterns PS00380 Rhodanese signature 1. 38 49 - T 09-03-2017 IPR001307 Thiosulphate sulfurtransferase, conserved site GO:0004792 KEGG: 00920+2.8.1.1|MetaCyc: PWY-5350 TK78_RS06960 7cbba464ab9a0d44571d95b5eab03e30 276 Gene3D G3DSA:3.40.250.10 1 144 4.7E-46 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS06960 7cbba464ab9a0d44571d95b5eab03e30 276 Gene3D G3DSA:3.40.250.10 149 274 2.1E-32 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS06960 7cbba464ab9a0d44571d95b5eab03e30 276 SMART SM00450 6 130 1.4E-22 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS06960 7cbba464ab9a0d44571d95b5eab03e30 276 SMART SM00450 148 267 7.8E-10 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS06960 7cbba464ab9a0d44571d95b5eab03e30 276 Pfam PF00581 Rhodanese-like domain 7 125 1.5E-18 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS06960 7cbba464ab9a0d44571d95b5eab03e30 276 Pfam PF00581 Rhodanese-like domain 160 263 2.2E-8 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS06960 7cbba464ab9a0d44571d95b5eab03e30 276 SUPERFAMILY SSF52821 3 143 4.71E-35 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS26025 a782e197900b5cac2add47230b679875 249 Pfam PF13411 MerR HTH family regulatory protein 1 68 4.1E-15 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS26025 a782e197900b5cac2add47230b679875 249 SMART SM00422 1 70 3.1E-22 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS26025 a782e197900b5cac2add47230b679875 249 Gene3D G3DSA:1.10.1660.10 1 110 2.3E-28 T 09-03-2017 TK78_RS26025 a782e197900b5cac2add47230b679875 249 SUPERFAMILY SSF46955 1 106 1.03E-24 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS10035 52040f13b64c3fd4c648918c76e226ee 69 SUPERFAMILY SSF88659 38 65 1.18E-5 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS10035 52040f13b64c3fd4c648918c76e226ee 69 Pfam PF08281 Sigma-70, region 4 30 68 2.2E-6 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS10035 52040f13b64c3fd4c648918c76e226ee 69 Gene3D G3DSA:1.10.10.60 37 64 6.7E-6 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS18390 dc46ca359e5870a95d83fcfe954a5509 375 Pfam PF00285 Citrate synthase, C-terminal domain 4 355 9.5E-120 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS18390 dc46ca359e5870a95d83fcfe954a5509 375 TIGRFAM TIGR01800 cit_synth_II: 2-methylcitrate synthase/citrate synthase II 3 367 2.9E-139 T 09-03-2017 IPR011278 2-methylcitrate synthase/citrate synthase type I GO:0005737|GO:0046912 TK78_RS18390 dc46ca359e5870a95d83fcfe954a5509 375 Gene3D G3DSA:1.10.580.10 12 232 2.6E-83 T 09-03-2017 IPR016142 Citrate synthase-like, large alpha subdomain Reactome: R-HSA-1268020|Reactome: R-HSA-71403 TK78_RS18390 dc46ca359e5870a95d83fcfe954a5509 375 ProSitePatterns PS00480 Citrate synthase signature. 253 265 - T 09-03-2017 IPR019810 Citrate synthase active site GO:0006099|GO:0046912 Reactome: R-HSA-1268020|Reactome: R-HSA-71403 TK78_RS18390 dc46ca359e5870a95d83fcfe954a5509 375 Gene3D G3DSA:1.10.230.10 233 320 6.8E-28 T 09-03-2017 IPR016143 Citrate synthase-like, small alpha subdomain Reactome: R-HSA-163765|Reactome: R-HSA-75105 TK78_RS18390 dc46ca359e5870a95d83fcfe954a5509 375 SUPERFAMILY SSF48256 2 366 1.28E-120 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS18390 dc46ca359e5870a95d83fcfe954a5509 375 PRINTS PR00143 Citrate synthase signature 171 186 7.1E-41 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS18390 dc46ca359e5870a95d83fcfe954a5509 375 PRINTS PR00143 Citrate synthase signature 122 135 7.1E-41 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS18390 dc46ca359e5870a95d83fcfe954a5509 375 PRINTS PR00143 Citrate synthase signature 246 266 7.1E-41 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS18390 dc46ca359e5870a95d83fcfe954a5509 375 PRINTS PR00143 Citrate synthase signature 306 322 7.1E-41 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS18390 dc46ca359e5870a95d83fcfe954a5509 375 PRINTS PR00143 Citrate synthase signature 326 340 7.1E-41 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS18390 dc46ca359e5870a95d83fcfe954a5509 375 PRINTS PR00143 Citrate synthase signature 193 221 7.1E-41 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS18390 dc46ca359e5870a95d83fcfe954a5509 375 PIRSF PIRSF001369 1 374 9.3E-121 T 09-03-2017 IPR024176 Citrate synthase, bacterial-type TK78_RS09955 3da9c550950a10a8c096f335384d345e 159 Gene3D G3DSA:3.30.450.30 12 143 6.9E-14 T 09-03-2017 TK78_RS09955 3da9c550950a10a8c096f335384d345e 159 SUPERFAMILY SSF103196 11 147 6.98E-21 T 09-03-2017 TK78_RS09955 3da9c550950a10a8c096f335384d345e 159 SMART SM00960 17 119 6.9E-14 T 09-03-2017 IPR004942 Roadblock/LAMTOR2 domain TK78_RS09955 3da9c550950a10a8c096f335384d345e 159 Pfam PF03259 Roadblock/LC7 domain 17 117 5.0E-12 T 09-03-2017 IPR004942 Roadblock/LAMTOR2 domain TK78_RS07220 b123919ec77723d62ae36094091bd6c0 429 Pfam PF00285 Citrate synthase, C-terminal domain 78 401 6.6E-61 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS07220 b123919ec77723d62ae36094091bd6c0 429 PRINTS PR00143 Citrate synthase signature 222 237 4.2E-24 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS07220 b123919ec77723d62ae36094091bd6c0 429 PRINTS PR00143 Citrate synthase signature 371 385 4.2E-24 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS07220 b123919ec77723d62ae36094091bd6c0 429 PRINTS PR00143 Citrate synthase signature 351 367 4.2E-24 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS07220 b123919ec77723d62ae36094091bd6c0 429 PRINTS PR00143 Citrate synthase signature 244 272 4.2E-24 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS07220 b123919ec77723d62ae36094091bd6c0 429 PRINTS PR00143 Citrate synthase signature 297 317 4.2E-24 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS07220 b123919ec77723d62ae36094091bd6c0 429 Pfam PF12728 Helix-turn-helix domain 15 64 2.6E-8 T 09-03-2017 TK78_RS07220 b123919ec77723d62ae36094091bd6c0 429 Gene3D G3DSA:1.10.10.10 15 63 5.1E-4 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS07220 b123919ec77723d62ae36094091bd6c0 429 Gene3D G3DSA:1.10.230.10 286 361 1.3E-13 T 09-03-2017 IPR016143 Citrate synthase-like, small alpha subdomain Reactome: R-HSA-163765|Reactome: R-HSA-75105 TK78_RS07220 b123919ec77723d62ae36094091bd6c0 429 Gene3D G3DSA:1.10.580.10 78 285 1.0E-38 T 09-03-2017 IPR016142 Citrate synthase-like, large alpha subdomain Reactome: R-HSA-1268020|Reactome: R-HSA-71403 TK78_RS07220 b123919ec77723d62ae36094091bd6c0 429 SUPERFAMILY SSF46955 15 63 8.55E-7 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS07220 b123919ec77723d62ae36094091bd6c0 429 SUPERFAMILY SSF48256 75 415 4.84E-69 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS09750 1130aa7a25a363ed5c2a30225f791c3c 591 Gene3D G3DSA:2.40.10.10 95 139 1.2E-12 T 09-03-2017 TK78_RS09750 1130aa7a25a363ed5c2a30225f791c3c 591 SUPERFAMILY SSF69318 291 565 7.32E-27 T 09-03-2017 TK78_RS09750 1130aa7a25a363ed5c2a30225f791c3c 591 Gene3D G3DSA:2.40.10.10 202 336 6.0E-33 T 09-03-2017 TK78_RS09750 1130aa7a25a363ed5c2a30225f791c3c 591 Pfam PF13517 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella 441 501 1.3E-10 T 09-03-2017 TK78_RS09750 1130aa7a25a363ed5c2a30225f791c3c 591 PRINTS PR00722 Chymotrypsin serine protease family (S1) signature 133 148 1.1E-10 T 09-03-2017 IPR001314 Peptidase S1A, chymotrypsin family GO:0004252|GO:0006508 TK78_RS09750 1130aa7a25a363ed5c2a30225f791c3c 591 PRINTS PR00722 Chymotrypsin serine protease family (S1) signature 288 300 1.1E-10 T 09-03-2017 IPR001314 Peptidase S1A, chymotrypsin family GO:0004252|GO:0006508 TK78_RS09750 1130aa7a25a363ed5c2a30225f791c3c 591 PRINTS PR00722 Chymotrypsin serine protease family (S1) signature 193 207 1.1E-10 T 09-03-2017 IPR001314 Peptidase S1A, chymotrypsin family GO:0004252|GO:0006508 TK78_RS09750 1130aa7a25a363ed5c2a30225f791c3c 591 Pfam PF00089 Trypsin 95 334 2.6E-40 T 09-03-2017 IPR001254 Serine proteases, trypsin domain GO:0004252|GO:0006508 TK78_RS09750 1130aa7a25a363ed5c2a30225f791c3c 591 ProSitePatterns PS00135 Serine proteases, trypsin family, serine active site. 289 300 - T 09-03-2017 IPR033116 Serine proteases, trypsin family, serine active site TK78_RS09750 1130aa7a25a363ed5c2a30225f791c3c 591 SUPERFAMILY SSF50494 88 333 3.46E-49 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS09750 1130aa7a25a363ed5c2a30225f791c3c 591 Gene3D G3DSA:2.40.10.10 140 201 1.4E-10 T 09-03-2017 TK78_RS09750 1130aa7a25a363ed5c2a30225f791c3c 591 SMART SM00020 94 335 1.8E-47 T 09-03-2017 IPR001254 Serine proteases, trypsin domain GO:0004252|GO:0006508 TK78_RS29400 c023be4ca1cafe0f82f8c2a82b2bab1c 318 Pfam PF13280 WYL domain 144 311 6.4E-30 T 09-03-2017 IPR026881 WYL domain TK78_RS29400 c023be4ca1cafe0f82f8c2a82b2bab1c 318 PIRSF PIRSF016838 2 318 8.4E-88 T 09-03-2017 IPR028349 Protein PafC TK78_RS14245 c74d4864360ace7f2d1721ab9d6c95ba 318 Pfam PF00892 EamA-like transporter family 173 303 3.3E-16 T 09-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 TK78_RS14245 c74d4864360ace7f2d1721ab9d6c95ba 318 SUPERFAMILY SSF103481 211 309 2.62E-9 T 09-03-2017 TK78_RS14245 c74d4864360ace7f2d1721ab9d6c95ba 318 SUPERFAMILY SSF103481 73 166 7.72E-7 T 09-03-2017 TK78_RS12725 0300725225928679b24819b7878ff565 112 Hamap MF_01479 Transcriptional regulator WhiB [whiB]. 1 93 19.382 T 09-03-2017 IPR003482 Transcription factor WhiB TK78_RS12725 0300725225928679b24819b7878ff565 112 Pfam PF02467 Transcription factor WhiB 17 87 8.5E-25 T 09-03-2017 IPR003482 Transcription factor WhiB TK78_RS05560 0f25bdec79e885fb647a4a745c7dd2be 563 ProSitePatterns PS00211 ABC transporters family signature. 466 480 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS05560 0f25bdec79e885fb647a4a745c7dd2be 563 Gene3D G3DSA:1.20.1560.10 13 321 1.4E-48 T 09-03-2017 TK78_RS05560 0f25bdec79e885fb647a4a745c7dd2be 563 SUPERFAMILY SSF90123 13 321 1.02E-52 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS05560 0f25bdec79e885fb647a4a745c7dd2be 563 Gene3D G3DSA:3.40.50.300 347 558 2.3E-44 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS05560 0f25bdec79e885fb647a4a745c7dd2be 563 Pfam PF00664 ABC transporter transmembrane region 25 288 7.1E-23 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS05560 0f25bdec79e885fb647a4a745c7dd2be 563 SUPERFAMILY SSF52540 344 559 2.81E-42 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS05560 0f25bdec79e885fb647a4a745c7dd2be 563 Pfam PF00005 ABC transporter 347 493 2.5E-15 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS24515 7267c1adf981caa7999373536b737944 427 SUPERFAMILY SSF52413 307 417 4.45E-10 T 09-03-2017 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 TK78_RS24515 7267c1adf981caa7999373536b737944 427 Pfam PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 1 182 5.3E-33 T 09-03-2017 IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 TK78_RS24515 7267c1adf981caa7999373536b737944 427 Pfam PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 214 299 2.1E-18 T 09-03-2017 IPR014026 UDP-glucose/GDP-mannose dehydrogenase, dimerisation GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 TK78_RS24515 7267c1adf981caa7999373536b737944 427 Gene3D G3DSA:3.40.50.720 1 234 5.1E-47 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS24515 7267c1adf981caa7999373536b737944 427 PIRSF PIRSF500136 1 424 1.6E-95 T 09-03-2017 IPR028359 UDP-N-acetyl-D-mannosamine/glucosamine dehydrogenase GO:0000271|GO:0016628|GO:0055114 TK78_RS24515 7267c1adf981caa7999373536b737944 427 SUPERFAMILY SSF51735 1 193 2.22E-40 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS24515 7267c1adf981caa7999373536b737944 427 SMART SM00984 322 414 6.4E-6 T 09-03-2017 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 TK78_RS24515 7267c1adf981caa7999373536b737944 427 Gene3D G3DSA:3.40.50.720 244 417 5.1E-28 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS24515 7267c1adf981caa7999373536b737944 427 SUPERFAMILY SSF48179 214 304 3.91E-21 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS24515 7267c1adf981caa7999373536b737944 427 PIRSF PIRSF000124 1 425 4.9E-47 T 09-03-2017 IPR017476 UDP-glucose/GDP-mannose dehydrogenase GO:0016616|GO:0055114 Reactome: R-HSA-173599 TK78_RS24515 7267c1adf981caa7999373536b737944 427 TIGRFAM TIGR03026 NDP-sugDHase: nucleotide sugar dehydrogenase 1 409 2.9E-84 T 09-03-2017 IPR017476 UDP-glucose/GDP-mannose dehydrogenase GO:0016616|GO:0055114 Reactome: R-HSA-173599 TK78_RS11385 fac89a287f0d70d325df180b0cd4404f 123 Pfam PF02467 Transcription factor WhiB 29 97 4.5E-21 T 09-03-2017 IPR003482 Transcription factor WhiB TK78_RS11385 fac89a287f0d70d325df180b0cd4404f 123 Hamap MF_01479 Transcriptional regulator WhiB [whiB]. 9 105 18.365 T 09-03-2017 IPR003482 Transcription factor WhiB TK78_RS17905 35178b9a7b1108e088246962a5b77255 140 Gene3D G3DSA:3.40.50.620 1 139 6.1E-37 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS17905 35178b9a7b1108e088246962a5b77255 140 SUPERFAMILY SSF52402 1 139 2.18E-36 T 09-03-2017 TK78_RS17905 35178b9a7b1108e088246962a5b77255 140 Pfam PF00582 Universal stress protein family 2 139 1.8E-30 T 09-03-2017 IPR006016 UspA GO:0006950 TK78_RS17905 35178b9a7b1108e088246962a5b77255 140 PRINTS PR01438 Universal stress protein signature 117 139 7.1E-18 T 09-03-2017 IPR006015 Universal stress protein A TK78_RS17905 35178b9a7b1108e088246962a5b77255 140 PRINTS PR01438 Universal stress protein signature 99 111 7.1E-18 T 09-03-2017 IPR006015 Universal stress protein A TK78_RS17905 35178b9a7b1108e088246962a5b77255 140 PRINTS PR01438 Universal stress protein signature 1 18 7.1E-18 T 09-03-2017 IPR006015 Universal stress protein A TK78_RS16505 d38042514fd41ea0c3aaaabef17a7e8c 510 Pfam PF04389 Peptidase family M28 250 468 1.1E-43 T 09-03-2017 IPR007484 Peptidase M28 TK78_RS16505 d38042514fd41ea0c3aaaabef17a7e8c 510 SUPERFAMILY SSF53187 234 474 1.86E-61 T 09-03-2017 TK78_RS16505 d38042514fd41ea0c3aaaabef17a7e8c 510 SUPERFAMILY SSF53187 45 93 1.86E-61 T 09-03-2017 TK78_RS16505 d38042514fd41ea0c3aaaabef17a7e8c 510 Gene3D G3DSA:3.50.30.30 106 237 4.1E-33 T 09-03-2017 TK78_RS16505 d38042514fd41ea0c3aaaabef17a7e8c 510 Gene3D G3DSA:3.40.630.10 41 104 2.8E-71 T 09-03-2017 TK78_RS16505 d38042514fd41ea0c3aaaabef17a7e8c 510 Gene3D G3DSA:3.40.630.10 249 475 2.8E-71 T 09-03-2017 TK78_RS16505 d38042514fd41ea0c3aaaabef17a7e8c 510 SUPERFAMILY SSF52025 126 221 4.84E-17 T 09-03-2017 TK78_RS16505 d38042514fd41ea0c3aaaabef17a7e8c 510 Pfam PF02225 PA domain 135 224 8.3E-15 T 09-03-2017 IPR003137 PA domain TK78_RS19560 2dc056ce15f44b382865721478cf3c14 276 Pfam PF01061 ABC-2 type transporter 27 232 4.4E-24 T 09-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 TK78_RS19560 2dc056ce15f44b382865721478cf3c14 276 PIRSF PIRSF006648 3 276 4.4E-69 T 09-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 TK78_RS07210 f36b9ae86650d8d9237f6a117493aed8 378 SUPERFAMILY SSF90002 244 334 4.71E-18 T 09-03-2017 IPR011629 Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal TK78_RS07210 f36b9ae86650d8d9237f6a117493aed8 378 SUPERFAMILY SSF52540 8 194 3.21E-33 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07210 f36b9ae86650d8d9237f6a117493aed8 378 Gene3D G3DSA:3.40.50.300 8 199 4.2E-54 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07210 f36b9ae86650d8d9237f6a117493aed8 378 SMART SM00833 243 334 2.5E-16 T 09-03-2017 IPR011629 Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal TK78_RS07210 f36b9ae86650d8d9237f6a117493aed8 378 Gene3D G3DSA:3.30.1220.10 225 335 3.8E-20 T 09-03-2017 IPR011629 Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal TK78_RS07210 f36b9ae86650d8d9237f6a117493aed8 378 Pfam PF07683 Cobalamin synthesis protein cobW C-terminal domain 244 334 3.6E-22 T 09-03-2017 IPR011629 Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal TK78_RS07210 f36b9ae86650d8d9237f6a117493aed8 378 Pfam PF02492 CobW/HypB/UreG, nucleotide-binding domain 10 184 2.3E-46 T 09-03-2017 IPR003495 CobW/HypB/UreG, nucleotide-binding domain TK78_RS05920 ad7146e80df698789f6f340d4a46c0a4 220 Gene3D G3DSA:3.40.50.2300 20 117 1.6E-9 T 09-03-2017 TK78_RS05920 ad7146e80df698789f6f340d4a46c0a4 220 ProSitePatterns PS00622 LuxR-type HTH domain signature. 173 200 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS05920 ad7146e80df698789f6f340d4a46c0a4 220 Gene3D G3DSA:1.10.10.10 143 218 1.3E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05920 ad7146e80df698789f6f340d4a46c0a4 220 SUPERFAMILY SSF46894 146 219 1.6E-18 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS05920 ad7146e80df698789f6f340d4a46c0a4 220 SMART SM00421 156 213 1.0E-21 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS05920 ad7146e80df698789f6f340d4a46c0a4 220 Pfam PF00196 Bacterial regulatory proteins, luxR family 159 213 2.5E-16 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS05920 ad7146e80df698789f6f340d4a46c0a4 220 SUPERFAMILY SSF52172 18 121 1.14E-11 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS05920 ad7146e80df698789f6f340d4a46c0a4 220 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 189 201 2.8E-12 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS05920 ad7146e80df698789f6f340d4a46c0a4 220 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 159 173 2.8E-12 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS05920 ad7146e80df698789f6f340d4a46c0a4 220 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 173 189 2.8E-12 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS05920 ad7146e80df698789f6f340d4a46c0a4 220 Pfam PF00072 Response regulator receiver domain 26 116 1.1E-5 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS07140 c1acd48126ca6f89bf7f0035a571507c 223 Pfam PF02585 GlcNAc-PI de-N-acetylase 6 125 1.8E-19 T 09-03-2017 IPR003737 N-acetylglucosaminyl phosphatidylinositol deacetylase-related Reactome: R-HSA-162710 TK78_RS07140 c1acd48126ca6f89bf7f0035a571507c 223 SUPERFAMILY SSF102588 4 222 2.62E-35 T 09-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 TK78_RS07140 c1acd48126ca6f89bf7f0035a571507c 223 Gene3D G3DSA:3.40.50.10320 3 221 4.8E-42 T 09-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 TK78_RS08785 85e3b41925d0ccc1495a4fd9cd9286e8 940 SUPERFAMILY SSF141868 659 903 7.32E-54 T 09-03-2017 IPR001633 EAL domain TK78_RS08785 85e3b41925d0ccc1495a4fd9cd9286e8 940 Pfam PF08448 PAS fold 362 467 3.3E-8 T 09-03-2017 IPR013656 PAS fold-4 TK78_RS08785 85e3b41925d0ccc1495a4fd9cd9286e8 940 Gene3D G3DSA:3.30.70.270 477 650 2.1E-54 T 09-03-2017 TK78_RS08785 85e3b41925d0ccc1495a4fd9cd9286e8 940 Pfam PF00990 Diguanylate cyclase, GGDEF domain 476 638 1.4E-40 T 09-03-2017 IPR000160 GGDEF domain TK78_RS08785 85e3b41925d0ccc1495a4fd9cd9286e8 940 SUPERFAMILY SSF55073 481 643 7.14E-43 T 09-03-2017 IPR029787 Nucleotide cyclase TK78_RS08785 85e3b41925d0ccc1495a4fd9cd9286e8 940 Gene3D G3DSA:3.20.20.450 655 904 1.0E-72 T 09-03-2017 IPR001633 EAL domain TK78_RS08785 85e3b41925d0ccc1495a4fd9cd9286e8 940 SUPERFAMILY SSF55785 345 463 5.03E-17 T 09-03-2017 IPR000014 PAS domain TK78_RS08785 85e3b41925d0ccc1495a4fd9cd9286e8 940 TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain 472 641 6.7E-39 T 09-03-2017 IPR000160 GGDEF domain TK78_RS08785 85e3b41925d0ccc1495a4fd9cd9286e8 940 Gene3D G3DSA:3.30.450.20 346 465 3.6E-18 T 09-03-2017 TK78_RS08785 85e3b41925d0ccc1495a4fd9cd9286e8 940 SMART SM00091 353 419 2.2E-9 T 09-03-2017 IPR000014 PAS domain TK78_RS08785 85e3b41925d0ccc1495a4fd9cd9286e8 940 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 350 472 7.1E-14 T 09-03-2017 IPR000014 PAS domain TK78_RS08785 85e3b41925d0ccc1495a4fd9cd9286e8 940 Pfam PF00563 EAL domain 659 893 3.3E-52 T 09-03-2017 IPR001633 EAL domain TK78_RS08785 85e3b41925d0ccc1495a4fd9cd9286e8 940 SMART SM00267 465 642 1.0E-54 T 09-03-2017 IPR000160 GGDEF domain TK78_RS08785 85e3b41925d0ccc1495a4fd9cd9286e8 940 SMART SM00052 652 898 1.1E-41 T 09-03-2017 IPR001633 EAL domain TK78_RS01590 85f43535fef5f623312adf93880000bb 226 Pfam PF13761 Domain of unknown function (DUF4166) 16 201 5.0E-64 T 09-03-2017 IPR025311 Domain of unknown function DUF4166 TK78_RS09985 a88e14f09a817e6abfa84294303d2b76 239 SUPERFAMILY SSF53335 23 212 2.62E-22 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS09985 a88e14f09a817e6abfa84294303d2b76 239 Gene3D G3DSA:3.40.50.150 78 208 1.3E-21 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS17805 28bf49442b673b185e960ac6596540e0 155 Pfam PF07179 SseB protein N-terminal domain 43 143 5.6E-7 T 09-03-2017 IPR009839 SseB protein N-terminal domain TK78_RS03135 5b556c1421105ac2db57623940959ef2 215 Gene3D G3DSA:3.40.50.1580 25 180 8.4E-24 T 09-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 TK78_RS03135 5b556c1421105ac2db57623940959ef2 215 SUPERFAMILY SSF53167 11 179 3.27E-26 T 09-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 TK78_RS03135 5b556c1421105ac2db57623940959ef2 215 Pfam PF01048 Phosphorylase superfamily 35 175 3.0E-16 T 09-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 TK78_RS24485 a1942c55b42c8770b3eaabe213cb8aab 260 TIGRFAM TIGR03936 sam_1_link_chp: radical SAM-linked protein 3 215 6.7E-53 T 09-03-2017 IPR018768 Domain of unknown function DUF2344 TK78_RS24485 a1942c55b42c8770b3eaabe213cb8aab 260 Pfam PF10105 Uncharacterized protein conserved in bacteria (DUF2344) 3 191 4.5E-47 T 09-03-2017 IPR018768 Domain of unknown function DUF2344 TK78_RS04160 5cc6fc02ea5c1cea3f38c850434c7566 334 Gene3D G3DSA:3.20.20.100 12 329 1.6E-88 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS04160 5cc6fc02ea5c1cea3f38c850434c7566 334 SUPERFAMILY SSF51430 12 330 6.81E-91 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS04160 5cc6fc02ea5c1cea3f38c850434c7566 334 Pfam PF00248 Aldo/keto reductase family 27 328 2.7E-71 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS30405 1a16a6079bdb6838dc1b2d06fd0b2a8c 152 Gene3D G3DSA:1.10.10.10 5 55 1.6E-18 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS30405 1a16a6079bdb6838dc1b2d06fd0b2a8c 152 Pfam PF01037 Lrp/AsnC ligand binding domain 69 139 1.5E-14 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS30405 1a16a6079bdb6838dc1b2d06fd0b2a8c 152 ProSitePatterns PS00519 AsnC-type HTH domain signature. 21 47 - T 09-03-2017 IPR019885 Transcription regulator HTH, AsnC-type, conserved site TK78_RS30405 1a16a6079bdb6838dc1b2d06fd0b2a8c 152 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 19 30 8.6E-10 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS30405 1a16a6079bdb6838dc1b2d06fd0b2a8c 152 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 30 49 8.6E-10 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS30405 1a16a6079bdb6838dc1b2d06fd0b2a8c 152 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 3 19 8.6E-10 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS30405 1a16a6079bdb6838dc1b2d06fd0b2a8c 152 Pfam PF13404 AsnC-type helix-turn-helix domain 3 44 1.2E-15 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS30405 1a16a6079bdb6838dc1b2d06fd0b2a8c 152 SUPERFAMILY SSF54909 65 144 8.58E-14 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS30405 1a16a6079bdb6838dc1b2d06fd0b2a8c 152 Gene3D G3DSA:3.30.70.920 56 135 7.3E-20 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS30405 1a16a6079bdb6838dc1b2d06fd0b2a8c 152 SUPERFAMILY SSF46785 2 63 5.66E-15 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS30405 1a16a6079bdb6838dc1b2d06fd0b2a8c 152 SMART SM00344 3 110 1.6E-29 T 09-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 TK78_RS26635 4bbf60aeb676f3c505ef20ea295ade83 462 Gene3D G3DSA:3.50.50.60 9 137 1.0E-38 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS26635 4bbf60aeb676f3c505ef20ea295ade83 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 10 32 5.0E-64 T 09-03-2017 TK78_RS26635 4bbf60aeb676f3c505ef20ea295ade83 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 174 199 5.0E-64 T 09-03-2017 TK78_RS26635 4bbf60aeb676f3c505ef20ea295ade83 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 337 358 5.0E-64 T 09-03-2017 TK78_RS26635 4bbf60aeb676f3c505ef20ea295ade83 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 301 308 5.0E-64 T 09-03-2017 TK78_RS26635 4bbf60aeb676f3c505ef20ea295ade83 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 424 444 5.0E-64 T 09-03-2017 TK78_RS26635 4bbf60aeb676f3c505ef20ea295ade83 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 138 147 5.0E-64 T 09-03-2017 TK78_RS26635 4bbf60aeb676f3c505ef20ea295ade83 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 42 57 5.0E-64 T 09-03-2017 TK78_RS26635 4bbf60aeb676f3c505ef20ea295ade83 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 259 273 5.0E-64 T 09-03-2017 TK78_RS26635 4bbf60aeb676f3c505ef20ea295ade83 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 402 417 5.0E-64 T 09-03-2017 TK78_RS26635 4bbf60aeb676f3c505ef20ea295ade83 462 Gene3D G3DSA:3.30.390.30 341 460 3.3E-27 T 09-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 TK78_RS26635 4bbf60aeb676f3c505ef20ea295ade83 462 Pfam PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 341 449 3.7E-23 T 09-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 TK78_RS26635 4bbf60aeb676f3c505ef20ea295ade83 462 ProSitePatterns PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 43 53 - T 09-03-2017 IPR012999 Pyridine nucleotide-disulphide oxidoreductase, class I, active site GO:0016668|GO:0055114 TK78_RS26635 4bbf60aeb676f3c505ef20ea295ade83 462 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 174 192 2.8E-34 T 09-03-2017 TK78_RS26635 4bbf60aeb676f3c505ef20ea295ade83 462 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 135 153 2.8E-34 T 09-03-2017 TK78_RS26635 4bbf60aeb676f3c505ef20ea295ade83 462 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 286 308 2.8E-34 T 09-03-2017 TK78_RS26635 4bbf60aeb676f3c505ef20ea295ade83 462 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 11 30 2.8E-34 T 09-03-2017 TK78_RS26635 4bbf60aeb676f3c505ef20ea295ade83 462 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 258 274 2.8E-34 T 09-03-2017 TK78_RS26635 4bbf60aeb676f3c505ef20ea295ade83 462 TIGRFAM TIGR01350 lipoamide_DH: dihydrolipoyl dehydrogenase 9 459 2.5E-136 T 09-03-2017 IPR006258 Dihydrolipoamide dehydrogenase GO:0004148|GO:0050660|GO:0055114 KEGG: 00010+1.8.1.4|KEGG: 00020+1.8.1.4|KEGG: 00260+1.8.1.4|KEGG: 00280+1.8.1.4|KEGG: 00620+1.8.1.4|KEGG: 00640+1.8.1.4|MetaCyc: PWY-5046|MetaCyc: PWY-5084|Reactome: R-HSA-204174|Reactome: R-HSA-389661|Reactome: R-HSA-5362517|Reactome: R-HSA-6783984|Reactome: R-HSA-70268|Reactome: R-HSA-70895|Reactome: R-HSA-71064|Reactome: R-HSA-71403 TK78_RS26635 4bbf60aeb676f3c505ef20ea295ade83 462 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 9 321 3.4E-68 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS26635 4bbf60aeb676f3c505ef20ea295ade83 462 SUPERFAMILY SSF55424 338 459 1.89E-28 T 09-03-2017 IPR016156 FAD/NAD-linked reductase, dimerisation domain GO:0016491|GO:0050660|GO:0055114 TK78_RS26635 4bbf60aeb676f3c505ef20ea295ade83 462 PIRSF PIRSF000350 1 436 2.4E-72 T 09-03-2017 TK78_RS26635 4bbf60aeb676f3c505ef20ea295ade83 462 SUPERFAMILY SSF51905 7 366 6.13E-60 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS26635 4bbf60aeb676f3c505ef20ea295ade83 462 Gene3D G3DSA:3.50.50.60 138 330 9.3E-48 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS21680 5843f5fc9aaca1fa12dc4eec2f055a9a 430 Pfam PF01471 Putative peptidoglycan binding domain 151 202 2.8E-8 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS21680 5843f5fc9aaca1fa12dc4eec2f055a9a 430 Gene3D G3DSA:1.10.101.10 141 193 1.6E-11 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS21680 5843f5fc9aaca1fa12dc4eec2f055a9a 430 SUPERFAMILY SSF47090 139 202 3.66E-10 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS10115 8811e425ec83a581be11b16c3f46cb13 311 Pfam PF12833 Helix-turn-helix domain 229 307 5.1E-21 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS10115 8811e425ec83a581be11b16c3f46cb13 311 Pfam PF01965 DJ-1/PfpI family 3 168 6.7E-20 T 09-03-2017 IPR002818 DJ-1/PfpI TK78_RS10115 8811e425ec83a581be11b16c3f46cb13 311 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 260 302 - T 09-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 TK78_RS10115 8811e425ec83a581be11b16c3f46cb13 311 Gene3D G3DSA:3.40.50.880 2 189 2.0E-48 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS10115 8811e425ec83a581be11b16c3f46cb13 311 SUPERFAMILY SSF46689 211 256 8.96E-11 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS10115 8811e425ec83a581be11b16c3f46cb13 311 Gene3D G3DSA:1.10.10.60 204 261 5.6E-18 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS10115 8811e425ec83a581be11b16c3f46cb13 311 SMART SM00342 223 306 2.9E-27 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS10115 8811e425ec83a581be11b16c3f46cb13 311 SUPERFAMILY SSF46689 260 309 2.99E-8 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS10115 8811e425ec83a581be11b16c3f46cb13 311 Gene3D G3DSA:1.10.10.60 262 309 7.9E-9 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS10115 8811e425ec83a581be11b16c3f46cb13 311 SUPERFAMILY SSF52317 1 189 8.13E-45 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS01780 fddb35e8ae1985578e85380249864eff 324 SUPERFAMILY SSF53807 38 318 4.32E-52 T 09-03-2017 TK78_RS01780 fddb35e8ae1985578e85380249864eff 324 Pfam PF01497 Periplasmic binding protein 57 299 9.5E-21 T 09-03-2017 IPR002491 ABC transporter periplasmic binding domain GO:0005488 TK78_RS01780 fddb35e8ae1985578e85380249864eff 324 Gene3D G3DSA:3.40.50.1980 36 156 4.8E-30 T 09-03-2017 TK78_RS01780 fddb35e8ae1985578e85380249864eff 324 Gene3D G3DSA:3.40.50.1980 157 323 9.1E-40 T 09-03-2017 TK78_RS32960 080452805c5cd0cbc86bff2d54cab1d3 377 SUPERFAMILY SSF46785 12 82 8.05E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32960 080452805c5cd0cbc86bff2d54cab1d3 377 SUPERFAMILY SSF53822 97 374 1.34E-44 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS32960 080452805c5cd0cbc86bff2d54cab1d3 377 Gene3D G3DSA:3.40.50.2300 212 371 2.4E-34 T 09-03-2017 TK78_RS32960 080452805c5cd0cbc86bff2d54cab1d3 377 Pfam PF00392 Bacterial regulatory proteins, gntR family 16 78 2.6E-21 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS32960 080452805c5cd0cbc86bff2d54cab1d3 377 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 52 68 4.8E-5 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS32960 080452805c5cd0cbc86bff2d54cab1d3 377 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 38 52 4.8E-5 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS32960 080452805c5cd0cbc86bff2d54cab1d3 377 SMART SM00345 19 78 3.6E-21 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS32960 080452805c5cd0cbc86bff2d54cab1d3 377 Gene3D G3DSA:3.40.50.2300 96 211 1.9E-22 T 09-03-2017 TK78_RS32960 080452805c5cd0cbc86bff2d54cab1d3 377 Pfam PF13377 Periplasmic binding protein-like domain 211 370 5.3E-31 T 09-03-2017 TK78_RS32960 080452805c5cd0cbc86bff2d54cab1d3 377 Gene3D G3DSA:1.10.10.10 13 84 8.6E-27 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS27760 204f8ba7a53b47b89825f1e8f47943a7 311 Hamap MF_01876 Pseudouridine-5'-phosphate glycosidase [psuG]. 15 309 38.908 T 09-03-2017 IPR007342 Pseudouridine-5'-phosphate glycosidase GO:0016798 KEGG: 00240+4.2.1.70|MetaCyc: PWY-6019 TK78_RS27760 204f8ba7a53b47b89825f1e8f47943a7 311 SUPERFAMILY SSF110581 12 307 4.32E-96 T 09-03-2017 TK78_RS27760 204f8ba7a53b47b89825f1e8f47943a7 311 Pfam PF04227 Indigoidine synthase A like protein 16 306 2.8E-110 T 09-03-2017 IPR007342 Pseudouridine-5'-phosphate glycosidase GO:0016798 KEGG: 00240+4.2.1.70|MetaCyc: PWY-6019 TK78_RS02005 b210962b4071fee10c403477e3109df2 56 SUPERFAMILY SSF57829 1 38 1.22E-9 T 09-03-2017 IPR011332 Zinc-binding ribosomal protein GO:0006412 TK78_RS02005 b210962b4071fee10c403477e3109df2 56 Hamap MF_00340 50S ribosomal protein L32 [rpmF]. 1 52 14.381 T 09-03-2017 IPR002677 Ribosomal protein L32p GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS02005 b210962b4071fee10c403477e3109df2 56 TIGRFAM TIGR01031 rpmF_bact: ribosomal protein bL32 2 45 1.2E-12 T 09-03-2017 IPR002677 Ribosomal protein L32p GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS02005 b210962b4071fee10c403477e3109df2 56 Pfam PF01783 Ribosomal L32p protein family 2 46 4.0E-13 T 09-03-2017 IPR002677 Ribosomal protein L32p GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 630 644 - T 09-03-2017 IPR019775 WD40 repeat, conserved site TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 SUPERFAMILY SSF52540 61 242 3.13E-21 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 SUPERFAMILY SSF50978 528 687 2.01E-39 T 09-03-2017 IPR017986 WD40-repeat-containing domain GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 880 894 - T 09-03-2017 IPR019775 WD40 repeat, conserved site TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 Gene3D G3DSA:2.130.10.10 890 1100 1.3E-48 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 Gene3D G3DSA:3.40.50.300 66 162 2.1E-4 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 755 769 - T 09-03-2017 IPR019775 WD40 repeat, conserved site TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 PRINTS PR00364 Disease resistance protein signature 145 159 2.2E-7 T 09-03-2017 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 PRINTS PR00364 Disease resistance protein signature 226 240 2.2E-7 T 09-03-2017 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 PRINTS PR00364 Disease resistance protein signature 67 82 2.2E-7 T 09-03-2017 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 Pfam PF00400 WD domain, G-beta repeat 730 768 1.4E-7 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 Pfam PF00400 WD domain, G-beta repeat 772 810 1.7E-5 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 Pfam PF00400 WD domain, G-beta repeat 945 977 5.3E-5 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 Pfam PF00400 WD domain, G-beta repeat 863 893 0.0062 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 Pfam PF00400 WD domain, G-beta repeat 698 725 8.1E-4 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 Pfam PF00400 WD domain, G-beta repeat 903 935 0.064 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 Pfam PF00400 WD domain, G-beta repeat 620 643 6.6E-4 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 Pfam PF00400 WD domain, G-beta repeat 566 600 1.2E-8 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 Pfam PF00400 WD domain, G-beta repeat 528 559 0.0046 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 Pfam PF00400 WD domain, G-beta repeat 1037 1063 0.012 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 Pfam PF00931 NB-ARC domain 63 203 3.0E-14 T 09-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 797 811 - T 09-03-2017 IPR019775 WD40 repeat, conserved site TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 Gene3D G3DSA:2.130.10.10 712 889 2.0E-57 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 SUPERFAMILY SSF50998 635 1010 5.02E-82 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 SMART SM00320 729 768 3.4E-10 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 SMART SM00320 980 1021 2.0 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 SMART SM00320 938 977 5.6E-6 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 SMART SM00320 646 685 0.94 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 SMART SM00320 855 893 9.9E-6 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 SMART SM00320 1024 1063 0.0011 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 SMART SM00320 896 935 2.1E-6 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 SMART SM00320 771 810 9.1E-10 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 SMART SM00320 520 559 1.9E-6 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 SMART SM00320 688 727 8.8E-5 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 SMART SM00320 562 601 5.5E-12 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 SMART SM00320 604 643 7.6E-5 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 SMART SM00320 813 852 1.2 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 Gene3D G3DSA:2.130.10.10 517 711 2.5E-55 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 672 686 - T 09-03-2017 IPR019775 WD40 repeat, conserved site TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 SUPERFAMILY SSF75011 994 1105 5.49E-16 T 09-03-2017 TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 964 978 - T 09-03-2017 IPR019775 WD40 repeat, conserved site TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 PRINTS PR00320 G protein beta WD-40 repeat signature 588 602 7.1E-7 T 09-03-2017 IPR020472 G-protein beta WD-40 repeat TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 PRINTS PR00320 G protein beta WD-40 repeat signature 755 769 7.1E-7 T 09-03-2017 IPR020472 G-protein beta WD-40 repeat TK78_RS01065 4f3d55873149ec7c036703934a8885b0 1109 PRINTS PR00320 G protein beta WD-40 repeat signature 797 811 7.1E-7 T 09-03-2017 IPR020472 G-protein beta WD-40 repeat TK78_RS10870 53fcc4bfb02f930d6b3a3972e135d4e0 624 SUPERFAMILY SSF52540 331 561 4.24E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10870 53fcc4bfb02f930d6b3a3972e135d4e0 624 SMART SM00382 362 546 6.9E-13 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS10870 53fcc4bfb02f930d6b3a3972e135d4e0 624 ProSitePatterns PS00211 ABC transporters family signature. 472 486 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS10870 53fcc4bfb02f930d6b3a3972e135d4e0 624 Gene3D G3DSA:3.40.50.300 337 562 9.4E-57 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10870 53fcc4bfb02f930d6b3a3972e135d4e0 624 Pfam PF00005 ABC transporter 353 499 3.5E-19 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS10870 53fcc4bfb02f930d6b3a3972e135d4e0 624 Gene3D G3DSA:1.20.1560.10 18 322 2.7E-39 T 09-03-2017 TK78_RS10870 53fcc4bfb02f930d6b3a3972e135d4e0 624 Pfam PF00664 ABC transporter transmembrane region 30 290 9.7E-15 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS10870 53fcc4bfb02f930d6b3a3972e135d4e0 624 SUPERFAMILY SSF90123 18 324 1.83E-39 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS13390 b4239f1985da0b6e3af379c800360255 666 Pfam PF00361 Proton-conducting membrane transporter 132 403 6.7E-75 T 09-03-2017 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13390 b4239f1985da0b6e3af379c800360255 666 TIGRFAM TIGR01974 NDH_I_L: proton-translocating NADH-quinone oxidoreductase, chain L 6 655 7.5E-137 T 09-03-2017 IPR003945 NADH-plastoquinone oxidoreductase, chain 5 GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13390 b4239f1985da0b6e3af379c800360255 666 Pfam PF00662 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus 68 119 3.2E-10 T 09-03-2017 IPR001516 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13390 b4239f1985da0b6e3af379c800360255 666 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 243 269 8.2E-49 T 09-03-2017 TK78_RS13390 b4239f1985da0b6e3af379c800360255 666 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 311 323 8.2E-49 T 09-03-2017 TK78_RS13390 b4239f1985da0b6e3af379c800360255 666 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 221 242 8.2E-49 T 09-03-2017 TK78_RS13390 b4239f1985da0b6e3af379c800360255 666 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 81 106 8.2E-49 T 09-03-2017 TK78_RS13390 b4239f1985da0b6e3af379c800360255 666 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 156 177 8.2E-49 T 09-03-2017 TK78_RS13390 b4239f1985da0b6e3af379c800360255 666 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 426 445 8.2E-49 T 09-03-2017 TK78_RS13390 b4239f1985da0b6e3af379c800360255 666 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 109 129 8.2E-49 T 09-03-2017 TK78_RS13390 b4239f1985da0b6e3af379c800360255 666 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 261 283 8.0E-8 T 09-03-2017 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 TK78_RS13390 b4239f1985da0b6e3af379c800360255 666 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 598 624 8.0E-8 T 09-03-2017 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 TK78_RS13390 b4239f1985da0b6e3af379c800360255 666 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 83 103 8.0E-8 T 09-03-2017 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 TK78_RS06945 c61732f4e73e8b40223c0c2f4c11ef20 439 SUPERFAMILY SSF56176 7 188 3.97E-47 T 09-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 TK78_RS06945 c61732f4e73e8b40223c0c2f4c11ef20 439 PIRSF PIRSF000136 1 439 8.0E-119 T 09-03-2017 IPR010031 L-gulonolactone/D-arabinono-1,4-lactone oxidase GO:0016899|GO:0055114 TK78_RS06945 c61732f4e73e8b40223c0c2f4c11ef20 439 Pfam PF04030 D-arabinono-1,4-lactone oxidase 182 436 2.0E-79 T 09-03-2017 IPR007173 D-arabinono-1,4-lactone oxidase GO:0003885|GO:0016020|GO:0055114 TK78_RS06945 c61732f4e73e8b40223c0c2f4c11ef20 439 Gene3D G3DSA:3.30.465.10 81 188 7.8E-31 T 09-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 TK78_RS06945 c61732f4e73e8b40223c0c2f4c11ef20 439 Pfam PF01565 FAD binding domain 28 158 1.1E-29 T 09-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 TK78_RS06945 c61732f4e73e8b40223c0c2f4c11ef20 439 Gene3D G3DSA:3.30.43.10 10 80 5.9E-24 T 09-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 TK78_RS06945 c61732f4e73e8b40223c0c2f4c11ef20 439 TIGRFAM TIGR01679 bact_FAD_ox: FAD-linked oxidoreductase 12 438 9.1E-122 T 09-03-2017 TK78_RS06945 c61732f4e73e8b40223c0c2f4c11ef20 439 ProSitePatterns PS00862 Oxygen oxidoreductases covalent FAD-binding site. 23 56 - T 09-03-2017 IPR006093 Oxygen oxidoreductase covalent FAD-binding site GO:0016491|GO:0055114 TK78_RS09255 59dcf1dc2e20e5d90de0ff673415a03e 413 Pfam PF03734 L,D-transpeptidase catalytic domain 252 359 7.1E-10 T 09-03-2017 IPR005490 L,D-transpeptidase catalytic domain GO:0016740 TK78_RS09255 59dcf1dc2e20e5d90de0ff673415a03e 413 Gene3D G3DSA:2.40.440.10 251 383 1.7E-15 T 09-03-2017 TK78_RS09255 59dcf1dc2e20e5d90de0ff673415a03e 413 SUPERFAMILY SSF141523 251 382 1.14E-17 T 09-03-2017 TK78_RS13235 fb516b0089d94afc6b4b9578f6a491d2 127 ProDom PD001326 RIBOSOMAL L7/L12 50S RIBONUCLEOPROTEIN CHLOROPLAST L12 PLASTID DIRECT SEQUENCING PEPTIDE 62 100 6.0E-15 T 09-03-2017 IPR013823 Ribosomal protein L7/L12, C-terminal GO:0003735|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13235 fb516b0089d94afc6b4b9578f6a491d2 127 Gene3D G3DSA:3.30.1390.10 55 127 1.3E-30 T 09-03-2017 IPR014719 Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like TK78_RS13235 fb516b0089d94afc6b4b9578f6a491d2 127 Pfam PF16320 Ribosomal protein L7/L12 dimerisation domain 7 53 6.8E-18 T 09-03-2017 IPR008932 Ribosomal protein L7/L12, oligomerisation GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13235 fb516b0089d94afc6b4b9578f6a491d2 127 Gene3D G3DSA:1.20.5.710 3 54 7.1E-20 T 09-03-2017 TK78_RS13235 fb516b0089d94afc6b4b9578f6a491d2 127 SUPERFAMILY SSF48300 5 63 2.09E-14 T 09-03-2017 IPR008932 Ribosomal protein L7/L12, oligomerisation GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13235 fb516b0089d94afc6b4b9578f6a491d2 127 SUPERFAMILY SSF54736 56 127 2.09E-22 T 09-03-2017 IPR014719 Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like TK78_RS13235 fb516b0089d94afc6b4b9578f6a491d2 127 Hamap MF_00368 50S ribosomal protein L7/L12 [rplL]. 3 127 22.606 T 09-03-2017 IPR000206 Ribosomal protein L7/L12 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13235 fb516b0089d94afc6b4b9578f6a491d2 127 TIGRFAM TIGR00855 L12: ribosomal protein bL12 1 127 2.6E-46 T 09-03-2017 IPR000206 Ribosomal protein L7/L12 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13235 fb516b0089d94afc6b4b9578f6a491d2 127 Pfam PF00542 Ribosomal protein L7/L12 C-terminal domain 61 127 8.5E-28 T 09-03-2017 IPR013823 Ribosomal protein L7/L12, C-terminal GO:0003735|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS25120 683d4dcece9928dec90db30a39f41dde 382 Gene3D G3DSA:3.20.20.70 17 259 1.7E-83 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS25120 683d4dcece9928dec90db30a39f41dde 382 SUPERFAMILY SSF51395 20 326 2.75E-78 T 09-03-2017 TK78_RS25120 683d4dcece9928dec90db30a39f41dde 382 TIGRFAM TIGR00737 nifR3_yhdG: putative TIM-barrel protein, nifR3 family 13 331 1.6E-111 T 09-03-2017 IPR004652 tRNA-dihydrouridine synthase, TIM-barrel, NifR3 GO:0008033|GO:0016491|GO:0050660|GO:0055114 TK78_RS25120 683d4dcece9928dec90db30a39f41dde 382 ProSitePatterns PS01136 Uncharacterized protein family UPF0034 signature. 107 125 - T 09-03-2017 IPR018517 tRNA-dihydrouridine synthase, conserved site GO:0008033|GO:0017150|GO:0050660|GO:0055114 TK78_RS25120 683d4dcece9928dec90db30a39f41dde 382 Gene3D G3DSA:1.10.1200.80 266 334 6.2E-17 T 09-03-2017 IPR024036 tRNA-dihydrouridine synthase, putative, C-terminal GO:0016491|GO:0055114 TK78_RS25120 683d4dcece9928dec90db30a39f41dde 382 Pfam PF01207 Dihydrouridine synthase (Dus) 23 328 1.6E-94 T 09-03-2017 IPR001269 tRNA-dihydrouridine synthase GO:0008033|GO:0017150|GO:0050660|GO:0055114 TK78_RS25120 683d4dcece9928dec90db30a39f41dde 382 PIRSF PIRSF006621 10 344 9.2E-102 T 09-03-2017 IPR001269 tRNA-dihydrouridine synthase GO:0008033|GO:0017150|GO:0050660|GO:0055114 TK78_RS13180 1c87758d34c849b3db38700ec5f251ce 676 SUPERFAMILY SSF102588 152 295 7.19E-20 T 09-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 TK78_RS13180 1c87758d34c849b3db38700ec5f251ce 676 SUPERFAMILY SSF102588 50 122 7.19E-20 T 09-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 TK78_RS13180 1c87758d34c849b3db38700ec5f251ce 676 Gene3D G3DSA:2.120.10.70 467 582 1.3E-5 T 09-03-2017 TK78_RS13180 1c87758d34c849b3db38700ec5f251ce 676 Gene3D G3DSA:3.40.50.10320 177 271 3.7E-21 T 09-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 TK78_RS13180 1c87758d34c849b3db38700ec5f251ce 676 Gene3D G3DSA:3.40.50.10320 50 136 3.7E-21 T 09-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 TK78_RS13180 1c87758d34c849b3db38700ec5f251ce 676 SUPERFAMILY SSF89372 443 674 2.75E-14 T 09-03-2017 TK78_RS13180 1c87758d34c849b3db38700ec5f251ce 676 Pfam PF02585 GlcNAc-PI de-N-acetylase 51 265 1.5E-24 T 09-03-2017 IPR003737 N-acetylglucosaminyl phosphatidylinositol deacetylase-related Reactome: R-HSA-162710 TK78_RS18465 0fcf1b837614de228a2ef86f5c5bd551 666 Gene3D G3DSA:1.10.10.10 216 275 9.7E-6 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS18465 0fcf1b837614de228a2ef86f5c5bd551 666 PRINTS PR01217 Proline rich extensin signature 426 442 3.7E-15 T 09-03-2017 TK78_RS18465 0fcf1b837614de228a2ef86f5c5bd551 666 PRINTS PR01217 Proline rich extensin signature 491 507 3.7E-15 T 09-03-2017 TK78_RS18465 0fcf1b837614de228a2ef86f5c5bd551 666 PRINTS PR01217 Proline rich extensin signature 467 488 3.7E-15 T 09-03-2017 TK78_RS18465 0fcf1b837614de228a2ef86f5c5bd551 666 PRINTS PR01217 Proline rich extensin signature 449 461 3.7E-15 T 09-03-2017 TK78_RS18465 0fcf1b837614de228a2ef86f5c5bd551 666 SUPERFAMILY SSF49785 528 663 1.15E-28 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS18465 0fcf1b837614de228a2ef86f5c5bd551 666 SUPERFAMILY SSF88946 91 190 4.71E-18 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS18465 0fcf1b837614de228a2ef86f5c5bd551 666 SUPERFAMILY SSF88659 215 274 3.55E-7 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS18465 0fcf1b837614de228a2ef86f5c5bd551 666 SMART SM00776 520 665 4.6E-30 T 09-03-2017 IPR013222 Glycosyl hydrolase family 98, putative carbohydrate-binding module TK78_RS18465 0fcf1b837614de228a2ef86f5c5bd551 666 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 107 275 3.0E-16 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS18465 0fcf1b837614de228a2ef86f5c5bd551 666 Gene3D G3DSA:1.10.1740.10 92 198 7.9E-20 T 09-03-2017 TK78_RS18465 0fcf1b837614de228a2ef86f5c5bd551 666 Pfam PF04542 Sigma-70 region 2 111 173 2.3E-8 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS18465 0fcf1b837614de228a2ef86f5c5bd551 666 Pfam PF08305 NPCBM/NEW2 domain 528 663 1.8E-24 T 09-03-2017 IPR013222 Glycosyl hydrolase family 98, putative carbohydrate-binding module TK78_RS10700 6ddab69ce1056bcdb402e2884a8e568b 285 Gene3D G3DSA:3.40.50.1820 16 280 3.5E-41 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS10700 6ddab69ce1056bcdb402e2884a8e568b 285 Pfam PF12697 Alpha/beta hydrolase family 41 274 2.6E-16 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS10700 6ddab69ce1056bcdb402e2884a8e568b 285 SUPERFAMILY SSF53474 23 279 2.41E-38 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS01545 b6d86111a51a5e2b4722d12c1ce9b3ac 321 Gene3D G3DSA:3.90.180.10 1 138 9.9E-38 T 09-03-2017 IPR011032 GroES-like TK78_RS01545 b6d86111a51a5e2b4722d12c1ce9b3ac 321 SMART SM00829 13 315 1.9E-38 T 09-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 TK78_RS01545 b6d86111a51a5e2b4722d12c1ce9b3ac 321 SUPERFAMILY SSF50129 1 133 5.17E-33 T 09-03-2017 IPR011032 GroES-like TK78_RS01545 b6d86111a51a5e2b4722d12c1ce9b3ac 321 Pfam PF00107 Zinc-binding dehydrogenase 144 261 3.7E-31 T 09-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 TK78_RS01545 b6d86111a51a5e2b4722d12c1ce9b3ac 321 Gene3D G3DSA:3.40.50.720 139 254 3.8E-33 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS01545 b6d86111a51a5e2b4722d12c1ce9b3ac 321 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 133 154 - T 09-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 TK78_RS01545 b6d86111a51a5e2b4722d12c1ce9b3ac 321 SUPERFAMILY SSF51735 105 262 2.69E-51 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS05420 58ba6f8adb9418618d10492a656cdd1c 516 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 184 281 1.2E-22 T 09-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS05420 58ba6f8adb9418618d10492a656cdd1c 516 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 420 499 5.2E-10 T 09-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS05420 58ba6f8adb9418618d10492a656cdd1c 516 Gene3D G3DSA:1.10.1040.10 419 496 1.3E-12 T 09-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 TK78_RS05420 58ba6f8adb9418618d10492a656cdd1c 516 Gene3D G3DSA:1.10.1040.10 186 281 2.3E-23 T 09-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 TK78_RS05420 58ba6f8adb9418618d10492a656cdd1c 516 Gene3D G3DSA:3.40.50.720 2 185 1.0E-48 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS05420 58ba6f8adb9418618d10492a656cdd1c 516 SUPERFAMILY SSF48179 418 501 2.3E-10 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS05420 58ba6f8adb9418618d10492a656cdd1c 516 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3 181 1.2E-52 T 09-03-2017 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS05420 58ba6f8adb9418618d10492a656cdd1c 516 SUPERFAMILY SSF51735 2 183 3.94E-47 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS05420 58ba6f8adb9418618d10492a656cdd1c 516 SUPERFAMILY SSF48179 183 288 1.87E-25 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS12775 a2aa38bfb145ad84cb34d86947751e7c 338 Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 38 327 6.7E-11 T 09-03-2017 IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0008152|GO:0016616|GO:0051287|GO:0055114 TK78_RS12775 a2aa38bfb145ad84cb34d86947751e7c 338 SUPERFAMILY SSF52283 42 140 6.38E-14 T 09-03-2017 TK78_RS12775 a2aa38bfb145ad84cb34d86947751e7c 338 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 124 298 1.8E-44 T 09-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 TK78_RS12775 a2aa38bfb145ad84cb34d86947751e7c 338 Gene3D G3DSA:3.40.50.720 122 300 1.2E-48 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS12775 a2aa38bfb145ad84cb34d86947751e7c 338 ProSitePatterns PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 209 231 - T 09-03-2017 IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site TK78_RS12775 a2aa38bfb145ad84cb34d86947751e7c 338 SUPERFAMILY SSF51735 112 299 3.94E-43 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS12775 a2aa38bfb145ad84cb34d86947751e7c 338 Gene3D G3DSA:3.40.50.720 40 121 7.1E-14 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS05110 c612f86da74cea53e6d3d15b6d51ca33 350 Gene3D G3DSA:1.20.1050.10 177 285 5.0E-22 T 09-03-2017 IPR010987 Glutathione S-transferase, C-terminal-like TK78_RS05110 c612f86da74cea53e6d3d15b6d51ca33 350 SUPERFAMILY SSF52833 36 154 1.01E-6 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS05110 c612f86da74cea53e6d3d15b6d51ca33 350 SUPERFAMILY SSF47616 173 338 7.52E-34 T 09-03-2017 IPR010987 Glutathione S-transferase, C-terminal-like TK78_RS05110 c612f86da74cea53e6d3d15b6d51ca33 350 Pfam PF13409 Glutathione S-transferase, N-terminal domain 60 154 1.1E-9 T 09-03-2017 IPR004045 Glutathione S-transferase, N-terminal GO:0005515 TK78_RS05110 c612f86da74cea53e6d3d15b6d51ca33 350 Pfam PF13410 Glutathione S-transferase, C-terminal domain 201 271 1.6E-12 T 09-03-2017 TK78_RS05110 c612f86da74cea53e6d3d15b6d51ca33 350 Gene3D G3DSA:3.40.30.10 36 176 6.8E-13 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS05110 c612f86da74cea53e6d3d15b6d51ca33 350 PIRSF PIRSF015753 12 321 8.4E-108 T 09-03-2017 IPR016639 Glutathione S-transferase (GST) KEGG: 00480+2.5.1.18|KEGG: 00980+2.5.1.18|KEGG: 00982+2.5.1.18|MetaCyc: PWY-4061|MetaCyc: PWY-6842|MetaCyc: PWY-7112|MetaCyc: PWY-7533 TK78_RS30265 0274cc240d164b86a377ef881decd443 146 Pfam PF01220 Dehydroquinase class II 4 140 4.5E-49 T 09-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 TK78_RS30265 0274cc240d164b86a377ef881decd443 146 PIRSF PIRSF001399 1 146 4.6E-53 T 09-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 TK78_RS30265 0274cc240d164b86a377ef881decd443 146 TIGRFAM TIGR01088 aroQ: 3-dehydroquinate dehydratase, type II 4 143 3.2E-51 T 09-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 TK78_RS30265 0274cc240d164b86a377ef881decd443 146 ProDom PD004527 LYASE II 3-DEHYDROQUINATE BIOSYNTHESIS DEHYDRATASE TYPE 3-DEHYDROQUINASE DHQASE AMINO AROMATIC 5 141 5.0E-40 T 09-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 TK78_RS30265 0274cc240d164b86a377ef881decd443 146 Hamap MF_00169 3-dehydroquinate dehydratase [aroQ]. 1 146 57.439 T 09-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 TK78_RS30265 0274cc240d164b86a377ef881decd443 146 ProSitePatterns PS01029 Dehydroquinase class II signature. 8 25 - T 09-03-2017 IPR018509 Dehydroquinase, class II, conserved site GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 TK78_RS30265 0274cc240d164b86a377ef881decd443 146 Gene3D G3DSA:3.40.50.9100 4 145 4.8E-54 T 09-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 TK78_RS30265 0274cc240d164b86a377ef881decd443 146 SUPERFAMILY SSF52304 4 144 6.67E-52 T 09-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 TK78_RS29420 68f96f7a6295f34a93c5c10a5b034ede 321 Pfam PF00902 Sec-independent protein translocase protein (TatC) 20 242 8.2E-59 T 09-03-2017 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 TK78_RS29420 68f96f7a6295f34a93c5c10a5b034ede 321 Hamap MF_00902 Sec-independent protein translocase protein TatC [tatC]. 10 261 16.865 T 09-03-2017 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 TK78_RS29420 68f96f7a6295f34a93c5c10a5b034ede 321 TIGRFAM TIGR00945 tatC: twin arginine-targeting protein translocase TatC 18 247 3.0E-56 T 09-03-2017 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 TK78_RS29420 68f96f7a6295f34a93c5c10a5b034ede 321 PRINTS PR01840 Bacterial Sec-independent translocation TatC protein family signature 17 44 4.4E-37 T 09-03-2017 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 TK78_RS29420 68f96f7a6295f34a93c5c10a5b034ede 321 PRINTS PR01840 Bacterial Sec-independent translocation TatC protein family signature 106 124 4.4E-37 T 09-03-2017 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 TK78_RS29420 68f96f7a6295f34a93c5c10a5b034ede 321 PRINTS PR01840 Bacterial Sec-independent translocation TatC protein family signature 124 150 4.4E-37 T 09-03-2017 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 TK78_RS29420 68f96f7a6295f34a93c5c10a5b034ede 321 PRINTS PR01840 Bacterial Sec-independent translocation TatC protein family signature 174 202 4.4E-37 T 09-03-2017 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 TK78_RS12605 9c5f0c994e82b35929e1be0185b862b9 428 SUPERFAMILY SSF55874 314 422 1.57E-12 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS12605 9c5f0c994e82b35929e1be0185b862b9 428 Pfam PF13581 Histidine kinase-like ATPase domain 298 387 1.2E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS12605 9c5f0c994e82b35929e1be0185b862b9 428 Pfam PF04024 PspC domain 22 77 2.2E-14 T 09-03-2017 IPR007168 Phage shock protein, PspC, N-terminal TK78_RS12605 9c5f0c994e82b35929e1be0185b862b9 428 Gene3D G3DSA:3.30.565.10 318 425 6.4E-9 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS07060 a8340b0841f35515c32598394b1af767 558 SUPERFAMILY SSF56801 15 531 1.7E-115 T 09-03-2017 TK78_RS07060 a8340b0841f35515c32598394b1af767 558 Gene3D G3DSA:3.40.50.980 178 324 4.0E-30 T 09-03-2017 TK78_RS07060 a8340b0841f35515c32598394b1af767 558 Gene3D G3DSA:2.30.38.10 339 424 3.0E-16 T 09-03-2017 TK78_RS07060 a8340b0841f35515c32598394b1af767 558 Pfam PF13193 AMP-binding enzyme C-terminal domain 439 518 6.3E-7 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS07060 a8340b0841f35515c32598394b1af767 558 ProSitePatterns PS00455 Putative AMP-binding domain signature. 168 179 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS07060 a8340b0841f35515c32598394b1af767 558 Gene3D G3DSA:3.30.300.30 425 530 4.9E-26 T 09-03-2017 TK78_RS07060 a8340b0841f35515c32598394b1af767 558 Pfam PF00501 AMP-binding enzyme 25 431 5.5E-76 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS07060 a8340b0841f35515c32598394b1af767 558 Gene3D G3DSA:3.40.50.980 14 177 2.4E-30 T 09-03-2017 TK78_RS34690 787e6a45d0d79e6e0d081eea3e7b17ae 251 Pfam PF13613 Helix-turn-helix of DDE superfamily endonuclease 34 85 1.8E-13 T 09-03-2017 IPR027805 Transposase, Helix-turn-helix domain TK78_RS34690 787e6a45d0d79e6e0d081eea3e7b17ae 251 Pfam PF13359 DDE superfamily endonuclease 102 247 3.5E-27 T 09-03-2017 IPR027806 Harbinger transposase-derived nuclease domain TK78_RS06155 c5488a81ba001d61623d41a57f571fcf 269 Gene3D G3DSA:3.40.30.10 75 252 5.6E-27 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS06155 c5488a81ba001d61623d41a57f571fcf 269 SUPERFAMILY SSF52833 70 249 8.01E-25 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS06155 c5488a81ba001d61623d41a57f571fcf 269 Pfam PF13462 Thioredoxin 75 251 4.5E-22 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS11000 3a65dea5d680af141e960a53cafb0825 624 Gene3D G3DSA:3.40.50.300 3 221 4.5E-56 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS11000 3a65dea5d680af141e960a53cafb0825 624 SUPERFAMILY SSF54980 318 405 1.65E-10 T 09-03-2017 IPR009022 Elongation factor G, III-V domain TK78_RS11000 3a65dea5d680af141e960a53cafb0825 624 SUPERFAMILY SSF54980 416 529 7.67E-27 T 09-03-2017 IPR009022 Elongation factor G, III-V domain TK78_RS11000 3a65dea5d680af141e960a53cafb0825 624 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 7 156 8.2E-22 T 09-03-2017 IPR005225 Small GTP-binding protein domain GO:0005525 TK78_RS11000 3a65dea5d680af141e960a53cafb0825 624 Gene3D G3DSA:3.30.70.240 420 498 4.7E-29 T 09-03-2017 IPR000640 Translation elongation factor EFG, V domain TK78_RS11000 3a65dea5d680af141e960a53cafb0825 624 Gene3D G3DSA:2.40.50.250 500 594 3.7E-36 T 09-03-2017 TK78_RS11000 3a65dea5d680af141e960a53cafb0825 624 Gene3D G3DSA:3.30.70.870 320 419 2.2E-34 T 09-03-2017 TK78_RS11000 3a65dea5d680af141e960a53cafb0825 624 Gene3D G3DSA:2.40.30.10 222 319 6.6E-29 T 09-03-2017 TK78_RS11000 3a65dea5d680af141e960a53cafb0825 624 Pfam PF00679 Elongation factor G C-terminus 414 497 1.0E-20 T 09-03-2017 IPR000640 Translation elongation factor EFG, V domain TK78_RS11000 3a65dea5d680af141e960a53cafb0825 624 PRINTS PR00315 GTP-binding elongation factor signature 9 22 1.4E-15 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS11000 3a65dea5d680af141e960a53cafb0825 624 PRINTS PR00315 GTP-binding elongation factor signature 55 63 1.4E-15 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS11000 3a65dea5d680af141e960a53cafb0825 624 PRINTS PR00315 GTP-binding elongation factor signature 97 108 1.4E-15 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS11000 3a65dea5d680af141e960a53cafb0825 624 PRINTS PR00315 GTP-binding elongation factor signature 81 91 1.4E-15 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS11000 3a65dea5d680af141e960a53cafb0825 624 PRINTS PR00315 GTP-binding elongation factor signature 133 142 1.4E-15 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS11000 3a65dea5d680af141e960a53cafb0825 624 Pfam PF00009 Elongation factor Tu GTP binding domain 6 211 1.8E-51 T 09-03-2017 TK78_RS11000 3a65dea5d680af141e960a53cafb0825 624 ProSitePatterns PS00301 Translational (tr)-type guanine nucleotide-binding (G) domain signature. 48 63 - T 09-03-2017 IPR031157 Tr-type G domain, conserved site TK78_RS11000 3a65dea5d680af141e960a53cafb0825 624 TIGRFAM TIGR01394 TypA_BipA: GTP-binding protein TypA/BipA 7 616 2.5E-284 T 09-03-2017 IPR006298 GTP-binding protein TypA GO:0005525 TK78_RS11000 3a65dea5d680af141e960a53cafb0825 624 SUPERFAMILY SSF52540 4 221 2.24E-50 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS11000 3a65dea5d680af141e960a53cafb0825 624 Pfam PF03144 Elongation factor Tu domain 2 235 305 2.4E-11 T 09-03-2017 IPR004161 Translation elongation factor EFTu-like, domain 2 GO:0005525 TK78_RS11000 3a65dea5d680af141e960a53cafb0825 624 SUPERFAMILY SSF50447 211 315 1.41E-31 T 09-03-2017 IPR009000 Translation protein, beta-barrel domain TK78_RS11000 3a65dea5d680af141e960a53cafb0825 624 SUPERFAMILY SSF50447 162 184 1.41E-31 T 09-03-2017 IPR009000 Translation protein, beta-barrel domain TK78_RS14315 975586b1ddfdbe6468da1b36703c6678 154 Pfam PF12802 MarR family 40 98 4.5E-9 T 09-03-2017 TK78_RS14315 975586b1ddfdbe6468da1b36703c6678 154 SUPERFAMILY SSF46785 4 150 7.21E-27 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS14315 975586b1ddfdbe6468da1b36703c6678 154 SMART SM00347 33 135 1.0E-11 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS14315 975586b1ddfdbe6468da1b36703c6678 154 Gene3D G3DSA:1.10.10.10 2 152 3.3E-33 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS30945 8ae108ce35e5710fe342da8836f3bcf4 360 SUPERFAMILY SSF103481 80 179 2.09E-12 T 09-03-2017 TK78_RS30945 8ae108ce35e5710fe342da8836f3bcf4 360 SUPERFAMILY SSF103481 229 330 2.75E-12 T 09-03-2017 TK78_RS30945 8ae108ce35e5710fe342da8836f3bcf4 360 Pfam PF00892 EamA-like transporter family 52 178 8.0E-20 T 09-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 TK78_RS30945 8ae108ce35e5710fe342da8836f3bcf4 360 Pfam PF00892 EamA-like transporter family 191 325 3.4E-17 T 09-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 TK78_RS18085 0eda7a3653ada2a86118b78e00ec18a5 486 Gene3D G3DSA:2.30.40.10 15 80 1.8E-18 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS18085 0eda7a3653ada2a86118b78e00ec18a5 486 Gene3D G3DSA:3.20.20.140 81 407 7.7E-90 T 09-03-2017 TK78_RS18085 0eda7a3653ada2a86118b78e00ec18a5 486 Pfam PF01979 Amidohydrolase family 63 441 1.3E-22 T 09-03-2017 IPR006680 Amidohydrolase-related GO:0016787 TK78_RS18085 0eda7a3653ada2a86118b78e00ec18a5 486 ProSitePatterns PS00482 Dihydroorotase signature 1. 70 78 - T 09-03-2017 IPR002195 Dihydroorotase, conserved site GO:0016812 KEGG: 00240+3.5.2.3|MetaCyc: PWY-5686 TK78_RS18085 0eda7a3653ada2a86118b78e00ec18a5 486 ProSitePatterns PS00483 Dihydroorotase signature 2. 319 330 - T 09-03-2017 IPR002195 Dihydroorotase, conserved site GO:0016812 KEGG: 00240+3.5.2.3|MetaCyc: PWY-5686 TK78_RS18085 0eda7a3653ada2a86118b78e00ec18a5 486 SUPERFAMILY SSF51338 387 456 1.76E-26 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS18085 0eda7a3653ada2a86118b78e00ec18a5 486 SUPERFAMILY SSF51338 15 66 1.76E-26 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS18085 0eda7a3653ada2a86118b78e00ec18a5 486 SUPERFAMILY SSF51556 67 387 2.56E-79 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS27625 e7e6311fb0eaa5c9d253beb187355154 411 Pfam PF13458 Periplasmic binding protein 41 399 1.9E-51 T 09-03-2017 IPR028081 Leucine-binding protein domain TK78_RS27625 e7e6311fb0eaa5c9d253beb187355154 411 SUPERFAMILY SSF53822 41 404 6.18E-80 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS27625 e7e6311fb0eaa5c9d253beb187355154 411 Gene3D G3DSA:3.40.50.2300 41 251 2.3E-57 T 09-03-2017 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SUPERFAMILY SSF52151 1596 1724 1.1E-63 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SUPERFAMILY SSF52151 1788 1884 1.1E-63 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SUPERFAMILY SSF52151 4351 4479 2.88E-65 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SUPERFAMILY SSF52151 4543 4639 2.88E-65 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SUPERFAMILY SSF47336 3721 3829 1.1E-21 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 1444 1549 3.2E-10 T 09-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 4192 4304 3.1E-10 T 09-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 3136 3266 2.9E-10 T 09-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SUPERFAMILY SSF56801 8 511 2.22E-147 T 09-03-2017 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:3.40.47.10 2760 3020 2.1E-88 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SUPERFAMILY SSF51735 4986 5217 6.29E-38 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 4991 5170 4.3E-33 T 09-03-2017 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 721 882 1.1E-8 T 09-03-2017 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2378 2558 5.4E-63 T 09-03-2017 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SUPERFAMILY SSF51735 719 879 3.36E-15 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SUPERFAMILY SSF53901 1212 1437 1.51E-104 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SUPERFAMILY SSF53901 1469 1479 1.51E-104 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SUPERFAMILY SSF53901 1059 1183 1.51E-104 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SUPERFAMILY SSF47336 5269 5350 3.66E-19 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 2921 2937 - T 09-03-2017 IPR018201 Beta-ketoacyl synthase, active site TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:3.40.50.720 4991 5198 3.6E-27 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:3.40.50.720 2378 2562 1.7E-36 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:3.30.300.30 412 508 2.2E-24 T 09-03-2017 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:2.30.38.10 334 408 3.9E-28 T 09-03-2017 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SUPERFAMILY SSF47336 963 1077 1.14E-20 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Pfam PF00501 AMP-binding enzyme 15 417 4.9E-102 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:3.30.70.250 3435 3500 7.3E-9 T 09-03-2017 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:3.30.70.250 4480 4541 1.5E-6 T 09-03-2017 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:3.30.70.250 1725 1786 3.1E-7 T 09-03-2017 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Pfam PF00698 Acyl transferase domain 4353 4670 9.8E-83 T 09-03-2017 IPR014043 Acyl transferase TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Pfam PF00698 Acyl transferase domain 1598 1915 6.5E-83 T 09-03-2017 IPR014043 Acyl transferase TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Pfam PF00698 Acyl transferase domain 3304 3628 2.0E-56 T 09-03-2017 IPR014043 Acyl transferase TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SUPERFAMILY SSF55048 3435 3500 2.49E-14 T 09-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:3.40.366.10 3295 3432 3.5E-77 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:3.40.366.10 3501 3624 3.5E-77 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SUPERFAMILY SSF52151 3301 3437 2.12E-69 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SUPERFAMILY SSF52151 3501 3594 2.12E-69 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Pfam PF14765 Polyketide synthase dehydratase 1964 2089 8.1E-9 T 09-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Pfam PF13193 AMP-binding enzyme C-terminal domain 426 500 3.2E-16 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 3305 3610 8.9E-126 T 09-03-2017 IPR020801 Polyketide synthase, acyl transferase domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 1600 1897 4.7E-110 T 09-03-2017 IPR020801 Polyketide synthase, acyl transferase domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 4355 4652 3.5E-111 T 09-03-2017 IPR020801 Polyketide synthase, acyl transferase domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1062 1316 1.5E-91 T 09-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 3814 4064 1.7E-90 T 09-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 2758 3008 1.0E-90 T 09-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SUPERFAMILY SSF53901 2755 3130 1.02E-100 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Pfam PF00550 Phosphopantetheine attachment site 970 1035 7.5E-9 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Pfam PF00550 Phosphopantetheine attachment site 2670 2731 3.0E-11 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Pfam PF00550 Phosphopantetheine attachment site 3725 3790 5.4E-11 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Pfam PF00550 Phosphopantetheine attachment site 5279 5344 2.1E-10 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SUPERFAMILY SSF55048 4479 4542 5.75E-11 T 09-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SMART SM00825 Beta-ketoacyl synthase 2760 3186 1.2E-223 T 09-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SMART SM00825 Beta-ketoacyl synthase 3816 4242 3.7E-228 T 09-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SMART SM00825 Beta-ketoacyl synthase 1064 1494 2.4E-224 T 09-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SUPERFAMILY SSF51735 2377 2612 1.14E-44 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:1.10.1200.10 3721 3794 1.2E-19 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:1.10.1200.10 965 1040 6.3E-20 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:1.10.1200.10 2660 2735 5.7E-20 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:1.10.1200.10 5274 5348 6.4E-20 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2690 2705 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SUPERFAMILY SSF53901 3811 4186 4.04E-103 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:3.40.47.10 1329 1495 7.0E-65 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:3.40.47.10 4077 4242 7.9E-66 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:3.40.47.10 3021 3186 1.2E-63 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SUPERFAMILY SSF55048 1724 1787 3.14E-12 T 09-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SUPERFAMILY SSF47336 2658 2772 9.55E-22 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SMART SM00826 1964 2115 1.4E-34 T 09-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 3977 3993 - T 09-03-2017 IPR018201 Beta-ketoacyl synthase, active site TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:3.40.47.10 1060 1328 2.1E-91 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:3.40.47.10 3812 4076 2.7E-89 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SMART SM00823 Phosphopantetheine attachment site 3722 3794 3.9E-26 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SMART SM00823 Phosphopantetheine attachment site 968 1040 1.5E-25 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SMART SM00823 Phosphopantetheine attachment site 2663 2735 2.6E-27 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SMART SM00823 Phosphopantetheine attachment site 5276 5348 5.8E-27 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SUPERFAMILY SSF51735 2204 2363 1.18E-19 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:3.40.50.980 175 329 5.7E-33 T 09-03-2017 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SUPERFAMILY SSF51735 519 704 3.27E-21 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Pfam PF08659 KR domain 2378 2556 4.9E-57 T 09-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Pfam PF08659 KR domain 721 880 9.0E-15 T 09-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Pfam PF08659 KR domain 4991 5168 1.5E-45 T 09-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SUPERFAMILY SSF51735 4770 4977 8.27E-44 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:3.40.366.10 4542 4653 6.9E-71 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:3.40.366.10 1787 1898 1.2E-69 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:3.40.366.10 4349 4473 6.9E-71 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:3.40.366.10 1594 1718 1.2E-69 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:3.40.50.720 721 879 2.8E-8 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Gene3D G3DSA:3.40.50.980 10 174 4.7E-37 T 09-03-2017 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 ProSitePatterns PS00455 Putative AMP-binding domain signature. 170 181 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 ProSitePatterns PS00012 Phosphopantetheine attachment site. 5303 5318 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SMART SM01294 5277 5344 4.2E-6 T 09-03-2017 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 SMART SM01294 3723 3790 3.9E-5 T 09-03-2017 TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 3016 3133 3.9E-43 T 09-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 4072 4189 3.4E-44 T 09-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 1324 1441 1.4E-43 T 09-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal TK78_RS31025 bdcba0295f76d491e753ae0dc4ce1f8a 5427 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1229 1245 - T 09-03-2017 IPR018201 Beta-ketoacyl synthase, active site TK78_RS22055 0e4079e42adda3f883647dc5e5ebdf3b 437 Pfam PF01345 Domain of unknown function DUF11 48 95 1.7E-7 T 09-03-2017 IPR001434 Domain of unknown function DUF11 TK78_RS22055 0e4079e42adda3f883647dc5e5ebdf3b 437 Pfam PF01882 Protein of unknown function DUF58 192 277 2.9E-18 T 09-03-2017 IPR002881 Domain of unknown function DUF58 TK78_RS12990 b1758ab43260f64f9af00eee1cd75f3e 452 Gene3D G3DSA:3.40.120.10 256 373 1.6E-31 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12990 b1758ab43260f64f9af00eee1cd75f3e 452 Gene3D G3DSA:3.40.120.10 4 154 2.9E-40 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12990 b1758ab43260f64f9af00eee1cd75f3e 452 Gene3D G3DSA:3.40.120.10 181 255 1.7E-24 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12990 b1758ab43260f64f9af00eee1cd75f3e 452 Pfam PF02880 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III 263 373 3.8E-32 T 09-03-2017 IPR005846 Alpha-D-phosphohexomutase, alpha/beta/alpha domain III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12990 b1758ab43260f64f9af00eee1cd75f3e 452 Pfam PF02879 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II 164 259 5.1E-18 T 09-03-2017 IPR005845 Alpha-D-phosphohexomutase, alpha/beta/alpha domain II GO:0005975 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12990 b1758ab43260f64f9af00eee1cd75f3e 452 TIGRFAM TIGR01455 glmM: phosphoglucosamine mutase 5 448 7.3E-169 T 09-03-2017 IPR006352 Phosphoglucosamine mutase, bacterial type GO:0000287|GO:0005975|GO:0008966 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12990 b1758ab43260f64f9af00eee1cd75f3e 452 Hamap MF_01554_B Phosphoglucosamine mutase [glmM]. 1 450 43.953 T 09-03-2017 IPR006352 Phosphoglucosamine mutase, bacterial type GO:0000287|GO:0005975|GO:0008966 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12990 b1758ab43260f64f9af00eee1cd75f3e 452 SUPERFAMILY SSF53738 4 185 2.04E-43 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12990 b1758ab43260f64f9af00eee1cd75f3e 452 SUPERFAMILY SSF53738 163 261 6.67E-27 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12990 b1758ab43260f64f9af00eee1cd75f3e 452 Pfam PF02878 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I 3 138 2.2E-37 T 09-03-2017 IPR005844 Alpha-D-phosphohexomutase, alpha/beta/alpha domain I GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12990 b1758ab43260f64f9af00eee1cd75f3e 452 SUPERFAMILY SSF55957 364 452 5.1E-22 T 09-03-2017 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12990 b1758ab43260f64f9af00eee1cd75f3e 452 Pfam PF00408 Phosphoglucomutase/phosphomannomutase, C-terminal domain 380 447 5.3E-12 T 09-03-2017 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12990 b1758ab43260f64f9af00eee1cd75f3e 452 Gene3D G3DSA:3.30.310.50 375 450 8.5E-19 T 09-03-2017 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12990 b1758ab43260f64f9af00eee1cd75f3e 452 SUPERFAMILY SSF53738 263 369 1.37E-28 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12990 b1758ab43260f64f9af00eee1cd75f3e 452 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 239 254 5.6E-11 T 09-03-2017 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12990 b1758ab43260f64f9af00eee1cd75f3e 452 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 179 198 5.6E-11 T 09-03-2017 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12990 b1758ab43260f64f9af00eee1cd75f3e 452 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 97 111 5.6E-11 T 09-03-2017 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS29880 12591eabc7326e6e958b3d18d6ea9763 167 SUPERFAMILY SSF55729 1 143 1.48E-25 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS29880 12591eabc7326e6e958b3d18d6ea9763 167 Gene3D G3DSA:3.40.630.30 2 160 7.1E-28 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS29880 12591eabc7326e6e958b3d18d6ea9763 167 Pfam PF00583 Acetyltransferase (GNAT) family 61 137 2.0E-12 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 Gene3D G3DSA:3.40.50.980 1574 1719 1.0E-29 T 09-03-2017 TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 Gene3D G3DSA:2.30.38.10 1720 1798 7.9E-27 T 09-03-2017 TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 SUPERFAMILY SSF52777 1132 1380 5.45E-56 T 09-03-2017 TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 Pfam PF00501 AMP-binding enzyme 1410 1808 7.7E-85 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 SUPERFAMILY SSF52777 2198 2429 4.0E-28 T 09-03-2017 TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 Pfam PF00550 Phosphopantetheine attachment site 1933 1998 4.0E-15 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 Gene3D G3DSA:3.40.50.980 1402 1573 7.5E-36 T 09-03-2017 TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 Gene3D G3DSA:3.90.1150.10 420 507 1.7E-31 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 Gene3D G3DSA:3.90.1150.10 87 161 1.7E-31 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 Pfam PF00296 Luciferase-like monooxygenase 610 849 2.2E-47 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 SUPERFAMILY SSF56801 1391 1903 1.57E-130 T 09-03-2017 TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 Gene3D G3DSA:1.10.1200.10 1929 2000 2.9E-19 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 Pfam PF00668 Condensation domain 2012 2297 3.8E-41 T 09-03-2017 IPR001242 Condensation domain TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 Pfam PF00668 Condensation domain 950 1244 2.1E-67 T 09-03-2017 IPR001242 Condensation domain TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 Gene3D G3DSA:3.30.300.30 1802 1906 1.4E-29 T 09-03-2017 TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 SUPERFAMILY SSF47336 1929 2006 1.7E-16 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 SUPERFAMILY SSF53383 96 508 1.67E-85 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 SMART SM00823 Phosphopantetheine attachment site 1931 2002 2.2E-11 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 Gene3D G3DSA:3.40.640.10 163 416 5.7E-63 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 Gene3D G3DSA:3.20.20.30 586 941 2.6E-70 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 Pfam PF13193 AMP-binding enzyme C-terminal domain 1816 1894 3.3E-7 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 Pfam PF00202 Aminotransferase class-III 123 458 5.5E-52 T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 SUPERFAMILY SSF52777 2014 2190 1.33E-36 T 09-03-2017 TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 1430 1832 3.3E-110 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1957 1972 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 TIGRFAM TIGR04020 seco_metab_LLM: natural product biosynthesis luciferase-like monooxygenase domain 594 936 9.0E-131 T 09-03-2017 IPR024011 Natural product biosynthesis luciferase-like monooxygenase domain TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 SUPERFAMILY SSF52777 953 1126 3.78E-44 T 09-03-2017 TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 Pfam PF13745 HxxPF-repeated domain 2356 2419 4.2E-6 T 09-03-2017 TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 Pfam PF13745 HxxPF-repeated domain 1266 1356 6.3E-24 T 09-03-2017 TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 SMART SM01294 1932 1998 0.0016 T 09-03-2017 TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 SUPERFAMILY SSF51679 594 930 4.84E-65 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS01890 a50cbb7e6fcd13c20247ab1e9bd6ebfe 2440 ProSitePatterns PS00455 Putative AMP-binding domain signature. 1551 1562 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS01075 dfea0d2b536d4cd394090c8bcca1924e 334 SUPERFAMILY SSF53795 154 205 2.9E-8 T 09-03-2017 TK78_RS01075 dfea0d2b536d4cd394090c8bcca1924e 334 Gene3D G3DSA:3.40.50.300 154 220 6.9E-12 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01075 dfea0d2b536d4cd394090c8bcca1924e 334 SUPERFAMILY SSF52540 170 303 8.82E-5 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS02790 890360a9bd83de9dd4d45f9e79e6d74f 367 Gene3D G3DSA:1.10.443.10 153 350 4.0E-34 T 09-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 TK78_RS02790 890360a9bd83de9dd4d45f9e79e6d74f 367 SUPERFAMILY SSF56349 152 352 3.83E-31 T 09-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 TK78_RS02790 890360a9bd83de9dd4d45f9e79e6d74f 367 Pfam PF00589 Phage integrase family 168 349 1.2E-19 T 09-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 TK78_RS02790 890360a9bd83de9dd4d45f9e79e6d74f 367 Gene3D G3DSA:1.10.150.130 77 116 0.001 T 09-03-2017 IPR023109 Integrase/recombinase, N-terminal TK78_RS05040 53013562d9be639edc6b4bef76120249 482 Gene3D G3DSA:2.60.40.710 44 193 6.4E-45 T 09-03-2017 IPR001956 Bacterial type 3a cellulose-binding domain GO:0005975|GO:0030248 TK78_RS05040 53013562d9be639edc6b4bef76120249 482 Pfam PF00942 Cellulose binding domain 46 128 1.8E-20 T 09-03-2017 IPR001956 Bacterial type 3a cellulose-binding domain GO:0005975|GO:0030248 TK78_RS05040 53013562d9be639edc6b4bef76120249 482 Pfam PF00722 Glycosyl hydrolases family 16 251 447 8.3E-6 T 09-03-2017 IPR000757 Glycoside hydrolase family 16 GO:0004553|GO:0005975 TK78_RS05040 53013562d9be639edc6b4bef76120249 482 SUPERFAMILY SSF49384 42 193 7.85E-41 T 09-03-2017 IPR008965 Carbohydrate-binding domain GO:0030246 TK78_RS05040 53013562d9be639edc6b4bef76120249 482 Gene3D G3DSA:2.60.120.200 218 448 2.3E-19 T 09-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain TK78_RS05040 53013562d9be639edc6b4bef76120249 482 SUPERFAMILY SSF49899 217 448 3.54E-19 T 09-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain TK78_RS05040 53013562d9be639edc6b4bef76120249 482 SMART SM01067 46 129 1.6E-26 T 09-03-2017 IPR001956 Bacterial type 3a cellulose-binding domain GO:0005975|GO:0030248 TK78_RS14530 09cb2646aaeac42cce6ce2d4c3f3de6f 673 SMART SM00062 419 655 5.2E-25 T 09-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF TK78_RS14530 09cb2646aaeac42cce6ce2d4c3f3de6f 673 Gene3D G3DSA:3.40.190.10 417 509 3.5E-20 T 09-03-2017 TK78_RS14530 09cb2646aaeac42cce6ce2d4c3f3de6f 673 Gene3D G3DSA:3.40.190.10 616 650 3.5E-20 T 09-03-2017 TK78_RS14530 09cb2646aaeac42cce6ce2d4c3f3de6f 673 SMART SM00220 36 301 3.6E-56 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS14530 09cb2646aaeac42cce6ce2d4c3f3de6f 673 Gene3D G3DSA:1.10.510.10 106 292 1.1E-45 T 09-03-2017 TK78_RS14530 09cb2646aaeac42cce6ce2d4c3f3de6f 673 SUPERFAMILY SSF53850 408 649 5.0E-33 T 09-03-2017 TK78_RS14530 09cb2646aaeac42cce6ce2d4c3f3de6f 673 SUPERFAMILY SSF53850 373 381 5.0E-33 T 09-03-2017 TK78_RS14530 09cb2646aaeac42cce6ce2d4c3f3de6f 673 Gene3D G3DSA:3.30.200.20 29 105 4.6E-22 T 09-03-2017 TK78_RS14530 09cb2646aaeac42cce6ce2d4c3f3de6f 673 Pfam PF00069 Protein kinase domain 36 255 2.5E-47 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS14530 09cb2646aaeac42cce6ce2d4c3f3de6f 673 Gene3D G3DSA:3.40.190.10 510 615 1.5E-6 T 09-03-2017 TK78_RS14530 09cb2646aaeac42cce6ce2d4c3f3de6f 673 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 42 65 - T 09-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 TK78_RS14530 09cb2646aaeac42cce6ce2d4c3f3de6f 673 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 159 171 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS14530 09cb2646aaeac42cce6ce2d4c3f3de6f 673 SUPERFAMILY SSF56112 33 336 3.46E-67 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS14530 09cb2646aaeac42cce6ce2d4c3f3de6f 673 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3 420 649 3.1E-32 T 09-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF TK78_RS13165 3da41d20cb864a5521f30ecee6a70f9c 214 Gene3D G3DSA:4.10.960.10 80 161 1.6E-33 T 09-03-2017 TK78_RS13165 3da41d20cb864a5521f30ecee6a70f9c 214 TIGRFAM TIGR03625 L3_bact: 50S ribosomal protein uL3 7 208 2.4E-91 T 09-03-2017 IPR019927 Ribosomal protein L3, bacterial/organelle-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13165 3da41d20cb864a5521f30ecee6a70f9c 214 Hamap MF_01325_B 50S ribosomal protein L3 [rplC]. 5 211 40.301 T 09-03-2017 IPR019927 Ribosomal protein L3, bacterial/organelle-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13165 3da41d20cb864a5521f30ecee6a70f9c 214 Pfam PF00297 Ribosomal protein L3 98 186 1.7E-15 T 09-03-2017 IPR000597 Ribosomal protein L3 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13165 3da41d20cb864a5521f30ecee6a70f9c 214 ProSitePatterns PS00474 Ribosomal protein L3 signature. 105 128 - T 09-03-2017 IPR019926 Ribosomal protein L3, conserved site TK78_RS13165 3da41d20cb864a5521f30ecee6a70f9c 214 Gene3D G3DSA:2.40.30.10 162 211 1.2E-12 T 09-03-2017 TK78_RS13165 3da41d20cb864a5521f30ecee6a70f9c 214 Gene3D G3DSA:2.40.30.10 7 36 1.2E-12 T 09-03-2017 TK78_RS13165 3da41d20cb864a5521f30ecee6a70f9c 214 SUPERFAMILY SSF50447 5 212 1.85E-81 T 09-03-2017 IPR009000 Translation protein, beta-barrel domain TK78_RS31370 c30e1b9faa0b286584985469e874f693 388 SUPERFAMILY SSF55874 261 369 2.46E-16 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS31370 c30e1b9faa0b286584985469e874f693 388 SMART SM00387 281 371 2.8E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS31370 c30e1b9faa0b286584985469e874f693 388 Pfam PF07730 Histidine kinase 173 239 5.9E-19 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS31370 c30e1b9faa0b286584985469e874f693 388 Gene3D G3DSA:3.30.565.10 256 372 3.4E-7 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS06855 5d5081034e8c25f3663ca41ea770b6f5 222 Gene3D G3DSA:3.40.50.720 2 140 1.8E-33 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS06855 5d5081034e8c25f3663ca41ea770b6f5 222 PRINTS PR00335 TrkA potassium uptake protein signature 2 16 8.0E-9 T 09-03-2017 IPR006036 Potassium uptake protein TrkA GO:0005886|GO:0006813|GO:0015079 TK78_RS06855 5d5081034e8c25f3663ca41ea770b6f5 222 PRINTS PR00335 TrkA potassium uptake protein signature 60 70 8.0E-9 T 09-03-2017 IPR006036 Potassium uptake protein TrkA GO:0005886|GO:0006813|GO:0015079 TK78_RS06855 5d5081034e8c25f3663ca41ea770b6f5 222 PRINTS PR00335 TrkA potassium uptake protein signature 19 33 8.0E-9 T 09-03-2017 IPR006036 Potassium uptake protein TrkA GO:0005886|GO:0006813|GO:0015079 TK78_RS06855 5d5081034e8c25f3663ca41ea770b6f5 222 PRINTS PR00335 TrkA potassium uptake protein signature 73 87 8.0E-9 T 09-03-2017 IPR006036 Potassium uptake protein TrkA GO:0005886|GO:0006813|GO:0015079 TK78_RS06855 5d5081034e8c25f3663ca41ea770b6f5 222 Pfam PF02080 TrkA-C domain 150 213 2.4E-12 T 09-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 TK78_RS06855 5d5081034e8c25f3663ca41ea770b6f5 222 Pfam PF02254 TrkA-N domain 3 116 5.5E-25 T 09-03-2017 IPR003148 Regulator of K+ conductance, N-terminal GO:0006813 TK78_RS06855 5d5081034e8c25f3663ca41ea770b6f5 222 Gene3D G3DSA:3.30.70.1450 146 213 2.3E-7 T 09-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 TK78_RS06855 5d5081034e8c25f3663ca41ea770b6f5 222 SUPERFAMILY SSF51735 2 140 5.51E-29 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS06855 5d5081034e8c25f3663ca41ea770b6f5 222 SUPERFAMILY SSF116726 139 213 1.23E-9 T 09-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 TK78_RS08415 d3d86d74f0efc2a295ae39a1319219b9 491 Hamap MF_00022_B Glutamate--tRNA ligase [gltX]. 6 486 32.306 T 09-03-2017 IPR004527 Glutamate-tRNA ligase, bacterial/mitochondrial GO:0000166|GO:0004818|GO:0005524|GO:0005737|GO:0006424 KEGG: 00860+6.1.1.17|KEGG: 00970+6.1.1.17|MetaCyc: PWY-5188|Reactome: R-HSA-379726 TK78_RS08415 d3d86d74f0efc2a295ae39a1319219b9 491 PRINTS PR00987 Glutamyl-tRNA synthetase signature 38 51 2.4E-22 T 09-03-2017 IPR000924 Glutamyl/glutaminyl-tRNA synthetase GO:0000166|GO:0005524|GO:0005737|GO:0016876|GO:0043039 TK78_RS08415 d3d86d74f0efc2a295ae39a1319219b9 491 PRINTS PR00987 Glutamyl-tRNA synthetase signature 194 204 2.4E-22 T 09-03-2017 IPR000924 Glutamyl/glutaminyl-tRNA synthetase GO:0000166|GO:0005524|GO:0005737|GO:0016876|GO:0043039 TK78_RS08415 d3d86d74f0efc2a295ae39a1319219b9 491 PRINTS PR00987 Glutamyl-tRNA synthetase signature 9 21 2.4E-22 T 09-03-2017 IPR000924 Glutamyl/glutaminyl-tRNA synthetase GO:0000166|GO:0005524|GO:0005737|GO:0016876|GO:0043039 TK78_RS08415 d3d86d74f0efc2a295ae39a1319219b9 491 PRINTS PR00987 Glutamyl-tRNA synthetase signature 23 34 2.4E-22 T 09-03-2017 IPR000924 Glutamyl/glutaminyl-tRNA synthetase GO:0000166|GO:0005524|GO:0005737|GO:0016876|GO:0043039 TK78_RS08415 d3d86d74f0efc2a295ae39a1319219b9 491 PRINTS PR00987 Glutamyl-tRNA synthetase signature 210 218 2.4E-22 T 09-03-2017 IPR000924 Glutamyl/glutaminyl-tRNA synthetase GO:0000166|GO:0005524|GO:0005737|GO:0016876|GO:0043039 TK78_RS08415 d3d86d74f0efc2a295ae39a1319219b9 491 Gene3D G3DSA:3.40.50.620 6 70 1.0E-43 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS08415 d3d86d74f0efc2a295ae39a1319219b9 491 Gene3D G3DSA:3.40.50.620 196 250 1.0E-43 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS08415 d3d86d74f0efc2a295ae39a1319219b9 491 SUPERFAMILY SSF52374 6 319 1.18E-104 T 09-03-2017 TK78_RS08415 d3d86d74f0efc2a295ae39a1319219b9 491 Gene3D G3DSA:3.90.800.10 71 194 1.3E-40 T 09-03-2017 TK78_RS08415 d3d86d74f0efc2a295ae39a1319219b9 491 TIGRFAM TIGR00464 gltX_bact: glutamate--tRNA ligase 6 484 1.6E-142 T 09-03-2017 IPR004527 Glutamate-tRNA ligase, bacterial/mitochondrial GO:0000166|GO:0004818|GO:0005524|GO:0005737|GO:0006424 KEGG: 00860+6.1.1.17|KEGG: 00970+6.1.1.17|MetaCyc: PWY-5188|Reactome: R-HSA-379726 TK78_RS08415 d3d86d74f0efc2a295ae39a1319219b9 491 Gene3D G3DSA:1.10.10.350 390 486 2.8E-20 T 09-03-2017 IPR020751 Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2 KEGG: 00860+6.1.1.17|KEGG: 00970+6.1.1.17|MetaCyc: PWY-5188|Reactome: R-HSA-379726 TK78_RS08415 d3d86d74f0efc2a295ae39a1319219b9 491 SUPERFAMILY SSF48163 320 486 1.7E-34 T 09-03-2017 IPR008925 Aminoacyl-tRNA synthetase, class I, anticodon-binding GO:0000049 KEGG: 00860+6.1.1.17|KEGG: 00970+6.1.1.17|MetaCyc: PWY-5188|Reactome: R-HSA-379726 TK78_RS08415 d3d86d74f0efc2a295ae39a1319219b9 491 Gene3D G3DSA:1.10.1160.10 253 335 2.3E-31 T 09-03-2017 IPR020061 Glutamyl/glutaminyl-tRNA synthetase, class Ib, alpha-bundle domain GO:0000166|GO:0004812|GO:0005524|GO:0005737|GO:0006418 KEGG: 00860+6.1.1.17|KEGG: 00970+6.1.1.17|MetaCyc: PWY-5188 TK78_RS08415 d3d86d74f0efc2a295ae39a1319219b9 491 Pfam PF00749 tRNA synthetases class I (E and Q), catalytic domain 6 323 9.8E-91 T 09-03-2017 IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain GO:0005524|GO:0016876|GO:0043039 TK78_RS05440 56bef14963c30b7a2219617da3b776b2 545 SUPERFAMILY SSF56645 62 282 1.2E-33 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS05440 56bef14963c30b7a2219617da3b776b2 545 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 285 438 1.4E-32 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS05440 56bef14963c30b7a2219617da3b776b2 545 ProSitePatterns PS00073 Acyl-CoA dehydrogenases signature 2. 397 416 - T 09-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 TK78_RS05440 56bef14963c30b7a2219617da3b776b2 545 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 180 275 3.1E-16 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS05440 56bef14963c30b7a2219617da3b776b2 545 Gene3D G3DSA:2.40.110.10 180 275 4.9E-21 T 09-03-2017 TK78_RS05440 56bef14963c30b7a2219617da3b776b2 545 ProSitePatterns PS00072 Acyl-CoA dehydrogenases signature 1. 182 194 - T 09-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 TK78_RS05440 56bef14963c30b7a2219617da3b776b2 545 Gene3D G3DSA:1.20.140.10 276 443 5.6E-44 T 09-03-2017 TK78_RS05440 56bef14963c30b7a2219617da3b776b2 545 SUPERFAMILY SSF47203 290 441 6.93E-43 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS07390 a966a9531b744fe12ed939e7ccc0dffb 506 PIRSF PIRSF006809 78 506 9.4E-156 T 09-03-2017 IPR016496 GTPase HflX GO:0005525 TK78_RS07390 a966a9531b744fe12ed939e7ccc0dffb 506 TIGRFAM TIGR03156 GTP_HflX: GTP-binding protein HflX 87 445 8.4E-129 T 09-03-2017 IPR016496 GTPase HflX GO:0005525 TK78_RS07390 a966a9531b744fe12ed939e7ccc0dffb 506 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 287 307 2.1E-6 T 09-03-2017 IPR006073 GTP binding domain GO:0005525 TK78_RS07390 a966a9531b744fe12ed939e7ccc0dffb 506 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 354 372 2.1E-6 T 09-03-2017 IPR006073 GTP binding domain GO:0005525 TK78_RS07390 a966a9531b744fe12ed939e7ccc0dffb 506 Pfam PF16360 GTP-binding GTPase Middle Region 193 279 1.4E-28 T 09-03-2017 IPR032305 GTP-binding protein, middle domain TK78_RS07390 a966a9531b744fe12ed939e7ccc0dffb 506 SUPERFAMILY SSF52540 276 447 1.0E-40 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07390 a966a9531b744fe12ed939e7ccc0dffb 506 Pfam PF13167 GTP-binding GTPase N-terminal 105 191 2.1E-31 T 09-03-2017 IPR025121 GTPase HflX, N-terminal TK78_RS07390 a966a9531b744fe12ed939e7ccc0dffb 506 Gene3D G3DSA:3.40.50.300 284 447 2.7E-37 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07390 a966a9531b744fe12ed939e7ccc0dffb 506 Pfam PF01926 50S ribosome-binding GTPase 287 405 1.8E-19 T 09-03-2017 IPR006073 GTP binding domain GO:0005525 TK78_RS07390 a966a9531b744fe12ed939e7ccc0dffb 506 Hamap MF_00900 GTPase HflX [hflX]. 106 475 47.37 T 09-03-2017 IPR016496 GTPase HflX GO:0005525 TK78_RS27455 8ac3d35fc4232cd7e9e720594e7d91bc 203 SUPERFAMILY SSF46689 8 89 9.75E-20 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS27455 8ac3d35fc4232cd7e9e720594e7d91bc 203 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 40 63 2.5E-10 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS27455 8ac3d35fc4232cd7e9e720594e7d91bc 203 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 19 32 2.5E-10 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS27455 8ac3d35fc4232cd7e9e720594e7d91bc 203 Gene3D G3DSA:1.10.10.60 11 64 3.1E-21 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS27455 8ac3d35fc4232cd7e9e720594e7d91bc 203 Pfam PF00440 Bacterial regulatory proteins, tetR family 19 65 3.3E-18 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS27455 8ac3d35fc4232cd7e9e720594e7d91bc 203 Gene3D G3DSA:1.10.357.10 65 200 4.3E-44 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS27455 8ac3d35fc4232cd7e9e720594e7d91bc 203 SUPERFAMILY SSF48498 87 200 1.95E-19 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS09280 d1cf07632e7d52b82b85a51c709b2cbc 305 Pfam PF00005 ABC transporter 20 157 3.5E-26 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS09280 d1cf07632e7d52b82b85a51c709b2cbc 305 SMART SM00382 28 206 4.4E-13 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS09280 d1cf07632e7d52b82b85a51c709b2cbc 305 Gene3D G3DSA:3.40.50.300 3 221 3.7E-65 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09280 d1cf07632e7d52b82b85a51c709b2cbc 305 SUPERFAMILY SSF52540 3 228 1.08E-60 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09280 d1cf07632e7d52b82b85a51c709b2cbc 305 ProSitePatterns PS00211 ABC transporters family signature. 130 144 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS03960 2c65d496176f4720a3cb3b234835aa20 393 Gene3D G3DSA:1.10.10.10 11 71 9.8E-11 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS03960 2c65d496176f4720a3cb3b234835aa20 393 ProSitePatterns PS01125 ROK family signature. 209 236 - T 09-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 TK78_RS03960 2c65d496176f4720a3cb3b234835aa20 393 Gene3D G3DSA:3.30.420.40 215 369 7.2E-52 T 09-03-2017 TK78_RS03960 2c65d496176f4720a3cb3b234835aa20 393 SUPERFAMILY SSF46785 8 69 9.58E-9 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS03960 2c65d496176f4720a3cb3b234835aa20 393 Gene3D G3DSA:3.30.420.40 77 214 4.9E-43 T 09-03-2017 TK78_RS03960 2c65d496176f4720a3cb3b234835aa20 393 SUPERFAMILY SSF53067 77 389 9.48E-63 T 09-03-2017 TK78_RS03960 2c65d496176f4720a3cb3b234835aa20 393 Pfam PF00480 ROK family 78 386 6.8E-61 T 09-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 TK78_RS31245 b46a5a463879906f3a1cfb6d01151f03 289 PRINTS PR01438 Universal stress protein signature 112 134 3.9E-11 T 09-03-2017 IPR006015 Universal stress protein A TK78_RS31245 b46a5a463879906f3a1cfb6d01151f03 289 PRINTS PR01438 Universal stress protein signature 5 23 3.9E-11 T 09-03-2017 IPR006015 Universal stress protein A TK78_RS31245 b46a5a463879906f3a1cfb6d01151f03 289 PRINTS PR01438 Universal stress protein signature 94 106 3.9E-11 T 09-03-2017 IPR006015 Universal stress protein A TK78_RS31245 b46a5a463879906f3a1cfb6d01151f03 289 SUPERFAMILY SSF52402 151 288 3.85E-13 T 09-03-2017 TK78_RS31245 b46a5a463879906f3a1cfb6d01151f03 289 Gene3D G3DSA:3.40.50.620 147 288 3.2E-17 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS31245 b46a5a463879906f3a1cfb6d01151f03 289 Gene3D G3DSA:3.40.50.620 7 133 1.7E-25 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS31245 b46a5a463879906f3a1cfb6d01151f03 289 SUPERFAMILY SSF52402 8 137 7.95E-25 T 09-03-2017 TK78_RS31245 b46a5a463879906f3a1cfb6d01151f03 289 Pfam PF00582 Universal stress protein family 152 288 2.8E-12 T 09-03-2017 IPR006016 UspA GO:0006950 TK78_RS31245 b46a5a463879906f3a1cfb6d01151f03 289 Pfam PF00582 Universal stress protein family 8 133 1.0E-16 T 09-03-2017 IPR006016 UspA GO:0006950 TK78_RS25960 5e527ae416aa0dbe94b25d33ee6a35e4 284 Pfam PF01575 MaoC like domain 161 261 1.8E-32 T 09-03-2017 IPR002539 MaoC-like domain TK78_RS25960 5e527ae416aa0dbe94b25d33ee6a35e4 284 Gene3D G3DSA:3.10.129.10 145 277 5.5E-46 T 09-03-2017 IPR029069 HotDog domain TK78_RS25960 5e527ae416aa0dbe94b25d33ee6a35e4 284 Pfam PF13452 N-terminal half of MaoC dehydratase 18 132 1.4E-12 T 09-03-2017 TK78_RS25960 5e527ae416aa0dbe94b25d33ee6a35e4 284 SUPERFAMILY SSF54637 15 158 3.25E-38 T 09-03-2017 IPR029069 HotDog domain TK78_RS25960 5e527ae416aa0dbe94b25d33ee6a35e4 284 SUPERFAMILY SSF54637 159 277 6.84E-34 T 09-03-2017 IPR029069 HotDog domain TK78_RS25960 5e527ae416aa0dbe94b25d33ee6a35e4 284 Gene3D G3DSA:3.10.129.10 1 144 1.2E-48 T 09-03-2017 IPR029069 HotDog domain TK78_RS12730 d9a3706bfdfb924afc827975788d69d1 296 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 5 63 2.3E-21 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS12730 d9a3706bfdfb924afc827975788d69d1 296 SUPERFAMILY SSF53850 91 295 5.89E-37 T 09-03-2017 TK78_RS12730 d9a3706bfdfb924afc827975788d69d1 296 Gene3D G3DSA:1.10.10.10 3 88 2.6E-27 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS12730 d9a3706bfdfb924afc827975788d69d1 296 Gene3D G3DSA:3.40.190.10 188 263 6.6E-22 T 09-03-2017 TK78_RS12730 d9a3706bfdfb924afc827975788d69d1 296 Pfam PF03466 LysR substrate binding domain 89 294 6.2E-44 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS12730 d9a3706bfdfb924afc827975788d69d1 296 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 19 30 1.3E-7 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS12730 d9a3706bfdfb924afc827975788d69d1 296 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 30 40 1.3E-7 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS12730 d9a3706bfdfb924afc827975788d69d1 296 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 40 51 1.3E-7 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS12730 d9a3706bfdfb924afc827975788d69d1 296 Gene3D G3DSA:3.40.190.10 89 187 6.4E-24 T 09-03-2017 TK78_RS12730 d9a3706bfdfb924afc827975788d69d1 296 SUPERFAMILY SSF46785 3 112 1.08E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS29000 0febd18ec27a386fa86fc2a64183e801 167 Gene3D G3DSA:1.20.120.450 7 167 2.5E-39 T 09-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase TK78_RS29000 0febd18ec27a386fa86fc2a64183e801 167 SUPERFAMILY SSF109854 11 162 1.24E-33 T 09-03-2017 TK78_RS29000 0febd18ec27a386fa86fc2a64183e801 167 Pfam PF04978 Protein of unknown function (DUF664) 27 163 8.9E-35 T 09-03-2017 IPR007061 Protein of unknown function DUF664 TK78_RS28665 e301a777a8e2cefef698667044aebe15 218 SUPERFAMILY SSF46785 97 170 1.04E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS28665 e301a777a8e2cefef698667044aebe15 218 SUPERFAMILY SSF46785 17 92 1.77E-18 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS28665 e301a777a8e2cefef698667044aebe15 218 TIGRFAM TIGR00281 TIGR00281: segregation and condensation protein B 19 182 8.2E-29 T 09-03-2017 IPR005234 Chromosome segregation/condensation protein ScpB GO:0051304 TK78_RS28665 e301a777a8e2cefef698667044aebe15 218 Gene3D G3DSA:1.10.10.10 97 170 2.0E-30 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS28665 e301a777a8e2cefef698667044aebe15 218 PIRSF PIRSF019345 2 216 1.9E-52 T 09-03-2017 IPR005234 Chromosome segregation/condensation protein ScpB GO:0051304 TK78_RS28665 e301a777a8e2cefef698667044aebe15 218 Pfam PF04079 Segregation and condensation complex subunit ScpB 22 179 2.3E-55 T 09-03-2017 IPR005234 Chromosome segregation/condensation protein ScpB GO:0051304 TK78_RS28665 e301a777a8e2cefef698667044aebe15 218 Gene3D G3DSA:1.10.10.10 18 93 2.6E-27 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS29185 e51f227cb64afa729927d00d593f8a46 443 SUPERFAMILY SSF53187 353 441 2.57E-53 T 09-03-2017 TK78_RS29185 e51f227cb64afa729927d00d593f8a46 443 SUPERFAMILY SSF53187 15 188 2.57E-53 T 09-03-2017 TK78_RS29185 e51f227cb64afa729927d00d593f8a46 443 ProSitePatterns PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 85 94 - T 09-03-2017 IPR001261 ArgE/DapE/ACY1/CPG2/YscS, conserved site GO:0006508|GO:0008237 TK78_RS29185 e51f227cb64afa729927d00d593f8a46 443 Pfam PF07687 Peptidase dimerisation domain 203 331 1.3E-14 T 09-03-2017 IPR011650 Peptidase M20, dimerisation domain TK78_RS29185 e51f227cb64afa729927d00d593f8a46 443 Gene3D G3DSA:3.30.70.360 293 338 5.0E-23 T 09-03-2017 IPR011650 Peptidase M20, dimerisation domain TK78_RS29185 e51f227cb64afa729927d00d593f8a46 443 Gene3D G3DSA:3.30.70.360 216 255 5.0E-23 T 09-03-2017 IPR011650 Peptidase M20, dimerisation domain TK78_RS29185 e51f227cb64afa729927d00d593f8a46 443 SUPERFAMILY SSF55031 206 245 1.7E-10 T 09-03-2017 IPR011650 Peptidase M20, dimerisation domain TK78_RS29185 e51f227cb64afa729927d00d593f8a46 443 SUPERFAMILY SSF55031 292 332 1.7E-10 T 09-03-2017 IPR011650 Peptidase M20, dimerisation domain TK78_RS29185 e51f227cb64afa729927d00d593f8a46 443 Pfam PF01546 Peptidase family M20/M25/M40 86 441 6.3E-36 T 09-03-2017 IPR002933 Peptidase M20 GO:0008152|GO:0016787 TK78_RS29185 e51f227cb64afa729927d00d593f8a46 443 Gene3D G3DSA:3.40.630.10 378 441 2.6E-59 T 09-03-2017 TK78_RS29185 e51f227cb64afa729927d00d593f8a46 443 Gene3D G3DSA:3.40.630.10 15 215 2.6E-59 T 09-03-2017 TK78_RS15285 7069a324fd0ef68d13b4f0b48be33d4a 1076 SUPERFAMILY SSF103473 39 478 3.01E-6 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS15285 7069a324fd0ef68d13b4f0b48be33d4a 1076 ProSitePatterns PS01331 Thymidylate kinase signature. 597 609 - T 09-03-2017 IPR018095 Thymidylate kinase, conserved site GO:0004798|GO:0005524|GO:0006233 KEGG: 00240+2.7.4.9|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7210|Reactome: R-HSA-499943 TK78_RS15285 7069a324fd0ef68d13b4f0b48be33d4a 1076 TIGRFAM TIGR00041 DTMP_kinase: dTMP kinase 507 695 4.2E-50 T 09-03-2017 IPR018094 Thymidylate kinase GO:0004798|GO:0005524|GO:0006233 KEGG: 00240+2.7.4.9|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7210|Reactome: R-HSA-499943 TK78_RS15285 7069a324fd0ef68d13b4f0b48be33d4a 1076 SUPERFAMILY SSF52540 507 707 1.84E-51 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15285 7069a324fd0ef68d13b4f0b48be33d4a 1076 Hamap MF_00165 Thymidylate kinase [tmk]. 508 707 30.79 T 09-03-2017 IPR018094 Thymidylate kinase GO:0004798|GO:0005524|GO:0006233 KEGG: 00240+2.7.4.9|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7210|Reactome: R-HSA-499943 TK78_RS15285 7069a324fd0ef68d13b4f0b48be33d4a 1076 Gene3D G3DSA:3.40.50.300 507 707 5.9E-72 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15285 7069a324fd0ef68d13b4f0b48be33d4a 1076 Pfam PF02223 Thymidylate kinase 512 695 3.0E-46 T 09-03-2017 TK78_RS15285 7069a324fd0ef68d13b4f0b48be33d4a 1076 Gene3D G3DSA:1.20.1250.20 290 474 4.1E-10 T 09-03-2017 TK78_RS20115 de07c9f2444c9923e5675363ceb6541e 588 Pfam PF01921 tRNA synthetases class I (K) 14 414 4.0E-126 T 09-03-2017 TK78_RS20115 de07c9f2444c9923e5675363ceb6541e 588 SUPERFAMILY SSF48163 378 586 3.92E-22 T 09-03-2017 IPR008925 Aminoacyl-tRNA synthetase, class I, anticodon-binding GO:0000049 KEGG: 00860+6.1.1.17|KEGG: 00970+6.1.1.17|MetaCyc: PWY-5188|Reactome: R-HSA-379726 TK78_RS20115 de07c9f2444c9923e5675363ceb6541e 588 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 44 53 - T 09-03-2017 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS20115 de07c9f2444c9923e5675363ceb6541e 588 Gene3D G3DSA:2.30.30.300 230 264 4.2E-8 T 09-03-2017 IPR023386 Lysine-tRNA ligase, insertion domain GO:0004824 KEGG: 00970+6.1.1.6 TK78_RS20115 de07c9f2444c9923e5675363ceb6541e 588 SUPERFAMILY SSF52374 219 372 8.32E-48 T 09-03-2017 TK78_RS20115 de07c9f2444c9923e5675363ceb6541e 588 SUPERFAMILY SSF52374 28 178 8.32E-48 T 09-03-2017 TK78_RS20115 de07c9f2444c9923e5675363ceb6541e 588 Hamap MF_00177 Lysine--tRNA ligase [lysS]. 13 588 30.888 T 09-03-2017 IPR002904 Lysine-tRNA ligase GO:0000166|GO:0004824|GO:0005524|GO:0005737|GO:0006430 KEGG: 00970+6.1.1.6 TK78_RS20115 de07c9f2444c9923e5675363ceb6541e 588 TIGRFAM TIGR00467 lysS_arch: lysine--tRNA ligase 223 585 1.0E-53 T 09-03-2017 IPR002904 Lysine-tRNA ligase GO:0000166|GO:0004824|GO:0005524|GO:0005737|GO:0006430 KEGG: 00970+6.1.1.6 TK78_RS20115 de07c9f2444c9923e5675363ceb6541e 588 Gene3D G3DSA:1.10.10.350 497 586 1.3E-17 T 09-03-2017 IPR020751 Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2 KEGG: 00860+6.1.1.17|KEGG: 00970+6.1.1.17|MetaCyc: PWY-5188|Reactome: R-HSA-379726 TK78_RS20115 de07c9f2444c9923e5675363ceb6541e 588 Gene3D G3DSA:3.40.50.620 325 374 4.7E-4 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS20115 de07c9f2444c9923e5675363ceb6541e 588 Gene3D G3DSA:3.40.50.620 273 324 5.8E-56 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS20115 de07c9f2444c9923e5675363ceb6541e 588 Gene3D G3DSA:3.40.50.620 222 229 5.8E-56 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS20115 de07c9f2444c9923e5675363ceb6541e 588 Gene3D G3DSA:3.40.50.620 24 175 5.8E-56 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS04550 001d3bcdd9719ebf559133ac95a32498 774 SUPERFAMILY SSF51726 12 400 2.35E-103 T 09-03-2017 TK78_RS04550 001d3bcdd9719ebf559133ac95a32498 774 PIRSF PIRSF000382 9 773 0.0 T 09-03-2017 IPR006276 Cobalamin-independent methionine synthase GO:0003871|GO:0008270|GO:0009086 KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6936|MetaCyc: PWY-702 TK78_RS04550 001d3bcdd9719ebf559133ac95a32498 774 Hamap MF_00172 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [metE]. 10 768 35.127 T 09-03-2017 IPR006276 Cobalamin-independent methionine synthase GO:0003871|GO:0008270|GO:0009086 KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6936|MetaCyc: PWY-702 TK78_RS04550 001d3bcdd9719ebf559133ac95a32498 774 Gene3D G3DSA:3.20.20.210 12 398 3.8E-141 T 09-03-2017 TK78_RS04550 001d3bcdd9719ebf559133ac95a32498 774 Pfam PF01717 Cobalamin-independent synthase, Catalytic domain 441 763 1.2E-145 T 09-03-2017 IPR002629 Cobalamin-independent methionine synthase MetE, C-terminal/archaeal GO:0003871|GO:0008270|GO:0009086 KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6936|MetaCyc: PWY-702 TK78_RS04550 001d3bcdd9719ebf559133ac95a32498 774 TIGRFAM TIGR01371 met_syn_B12ind: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase 16 768 0.0 T 09-03-2017 IPR006276 Cobalamin-independent methionine synthase GO:0003871|GO:0008270|GO:0009086 KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6936|MetaCyc: PWY-702 TK78_RS04550 001d3bcdd9719ebf559133ac95a32498 774 SUPERFAMILY SSF51726 406 767 1.83E-114 T 09-03-2017 TK78_RS04550 001d3bcdd9719ebf559133ac95a32498 774 Pfam PF08267 Cobalamin-independent synthase, N-terminal domain 13 323 3.7E-116 T 09-03-2017 IPR013215 Cobalamin-independent methionine synthase MetE, N-terminal GO:0003871|GO:0008270|GO:0008652 KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6936|MetaCyc: PWY-702 TK78_RS04550 001d3bcdd9719ebf559133ac95a32498 774 Gene3D G3DSA:3.20.20.210 403 769 3.6E-130 T 09-03-2017 TK78_RS29615 e6a64a50994f81d29cf4de47ce9e34a1 450 SUPERFAMILY SSF48452 209 321 4.91E-6 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS29615 e6a64a50994f81d29cf4de47ce9e34a1 450 Gene3D G3DSA:1.25.40.10 215 398 3.3E-8 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS29425 b273827076a550f310727da32f005b1b 297 TIGRFAM TIGR00147 TIGR00147: lipid kinase, YegS/Rv2252/BmrU family 4 295 7.5E-40 T 09-03-2017 IPR005218 Diacylglycerol/lipid kinase TK78_RS29425 b273827076a550f310727da32f005b1b 297 SUPERFAMILY SSF111331 5 295 4.36E-69 T 09-03-2017 IPR016064 NAD kinase/diacylglycerol kinase-like domain TK78_RS29425 b273827076a550f310727da32f005b1b 297 SMART SM00046 4 135 4.4E-4 T 09-03-2017 IPR001206 Diacylglycerol kinase, catalytic domain GO:0016301 TK78_RS29425 b273827076a550f310727da32f005b1b 297 Pfam PF00781 Diacylglycerol kinase catalytic domain 5 131 4.9E-25 T 09-03-2017 IPR001206 Diacylglycerol kinase, catalytic domain GO:0016301 TK78_RS10860 1624bf7b0e8caac3edd2dea0cdca98e0 201 Pfam PF00196 Bacterial regulatory proteins, luxR family 140 195 4.9E-12 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS10860 1624bf7b0e8caac3edd2dea0cdca98e0 201 Pfam PF00072 Response regulator receiver domain 4 113 3.7E-6 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS10860 1624bf7b0e8caac3edd2dea0cdca98e0 201 Gene3D G3DSA:3.40.50.2300 1 127 1.8E-12 T 09-03-2017 TK78_RS10860 1624bf7b0e8caac3edd2dea0cdca98e0 201 ProSitePatterns PS00622 LuxR-type HTH domain signature. 155 182 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS10860 1624bf7b0e8caac3edd2dea0cdca98e0 201 Gene3D G3DSA:1.10.10.10 138 201 5.4E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS10860 1624bf7b0e8caac3edd2dea0cdca98e0 201 SUPERFAMILY SSF46894 129 201 1.12E-15 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS10860 1624bf7b0e8caac3edd2dea0cdca98e0 201 SMART SM00421 138 195 8.7E-17 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS10860 1624bf7b0e8caac3edd2dea0cdca98e0 201 SUPERFAMILY SSF52172 1 129 5.42E-13 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS10860 1624bf7b0e8caac3edd2dea0cdca98e0 201 SMART SM00448 2 115 5.6E-11 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS10860 1624bf7b0e8caac3edd2dea0cdca98e0 201 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 141 155 8.6E-6 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS10860 1624bf7b0e8caac3edd2dea0cdca98e0 201 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 171 183 8.6E-6 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS10860 1624bf7b0e8caac3edd2dea0cdca98e0 201 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 155 171 8.6E-6 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS06575 4e879d7724ef82a97c2b7c5b74ecd225 328 SUPERFAMILY SSF161098 103 315 7.41E-16 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS06575 4e879d7724ef82a97c2b7c5b74ecd225 328 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 128 327 3.3E-35 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS06575 4e879d7724ef82a97c2b7c5b74ecd225 328 Gene3D G3DSA:1.10.3720.10 102 322 5.8E-15 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS09130 ae3272fa44340654eae9ebae5547a8f9 1085 SUPERFAMILY SSF69304 86 346 2.48E-21 T 09-03-2017 TK78_RS09130 ae3272fa44340654eae9ebae5547a8f9 1085 Gene3D G3DSA:2.120.10.30 91 231 5.4E-25 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS09130 ae3272fa44340654eae9ebae5547a8f9 1085 Gene3D G3DSA:2.130.10.10 275 337 3.5E-27 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS09130 ae3272fa44340654eae9ebae5547a8f9 1085 Gene3D G3DSA:2.130.10.10 536 697 3.6E-17 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS09130 ae3272fa44340654eae9ebae5547a8f9 1085 Gene3D G3DSA:2.130.10.10 423 535 3.5E-27 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS09130 ae3272fa44340654eae9ebae5547a8f9 1085 Pfam PF01345 Domain of unknown function DUF11 703 753 1.6E-6 T 09-03-2017 IPR001434 Domain of unknown function DUF11 TK78_RS09130 ae3272fa44340654eae9ebae5547a8f9 1085 Pfam PF07676 WD40-like Beta Propeller Repeat 468 490 1.5E-5 T 09-03-2017 IPR011659 WD40-like Beta Propeller TK78_RS09130 ae3272fa44340654eae9ebae5547a8f9 1085 Pfam PF07676 WD40-like Beta Propeller Repeat 522 556 0.0023 T 09-03-2017 IPR011659 WD40-like Beta Propeller TK78_RS09130 ae3272fa44340654eae9ebae5547a8f9 1085 Pfam PF07676 WD40-like Beta Propeller Repeat 167 205 6.4E-8 T 09-03-2017 IPR011659 WD40-like Beta Propeller TK78_RS09130 ae3272fa44340654eae9ebae5547a8f9 1085 Pfam PF07676 WD40-like Beta Propeller Repeat 580 597 0.055 T 09-03-2017 IPR011659 WD40-like Beta Propeller TK78_RS09130 ae3272fa44340654eae9ebae5547a8f9 1085 SUPERFAMILY SSF82171 404 692 1.14E-25 T 09-03-2017 TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 Pfam PF08238 Sel1 repeat 635 651 170.0 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 Pfam PF08238 Sel1 repeat 152 182 0.62 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 Pfam PF08238 Sel1 repeat 353 382 14.0 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 Pfam PF08238 Sel1 repeat 466 478 25.0 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 Pfam PF08238 Sel1 repeat 305 318 0.47 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 Pfam PF08238 Sel1 repeat 427 446 0.28 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 Pfam PF08238 Sel1 repeat 215 246 93.0 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 Pfam PF08238 Sel1 repeat 480 510 0.024 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 Pfam PF08238 Sel1 repeat 543 587 0.0013 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 Pfam PF08238 Sel1 repeat 602 619 0.23 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 Pfam PF08238 Sel1 repeat 201 213 17.0 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 Gene3D G3DSA:1.25.40.10 70 246 2.0E-27 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 Gene3D G3DSA:1.25.40.10 301 490 9.6E-39 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 Gene3D G3DSA:1.25.40.10 496 698 1.3E-32 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 SUPERFAMILY SSF81901 572 685 2.22E-19 T 09-03-2017 TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 SUPERFAMILY SSF81901 80 244 1.05E-17 T 09-03-2017 TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 SMART SM00671 447 478 9.8 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 SMART SM00671 151 182 0.37 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 SMART SM00671 119 150 53.0 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 SMART SM00671 479 510 0.56 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 SMART SM00671 415 446 14.0 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 SMART SM00671 543 587 64.0 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 SMART SM00671 183 213 6.0 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 SMART SM00671 383 414 40.0 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 SMART SM00671 351 382 5.5 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 SMART SM00671 319 350 160.0 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 SMART SM00671 620 651 13.0 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 SMART SM00671 511 542 240.0 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 SMART SM00671 588 619 4.5 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 SMART SM00671 214 247 190.0 T 09-03-2017 IPR006597 Sel1-like repeat TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 SUPERFAMILY SSF81901 301 488 4.45E-28 T 09-03-2017 TK78_RS10495 1dc62b6b192829429bea207332909b0f 703 SUPERFAMILY SSF81901 461 552 7.32E-14 T 09-03-2017 TK78_RS19250 d5b7e3d5c3ba5319656677733d85eb96 845 SUPERFAMILY SSF52777 33 242 1.33E-21 T 09-03-2017 TK78_RS19250 d5b7e3d5c3ba5319656677733d85eb96 845 ProSitePatterns PS00012 Phosphopantetheine attachment site. 804 819 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS19250 d5b7e3d5c3ba5319656677733d85eb96 845 ProSitePatterns PS00455 Putative AMP-binding domain signature. 419 430 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS19250 d5b7e3d5c3ba5319656677733d85eb96 845 Pfam PF00501 AMP-binding enzyme 278 673 2.4E-81 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS19250 d5b7e3d5c3ba5319656677733d85eb96 845 SMART SM01294 781 845 7.1E-4 T 09-03-2017 TK78_RS19250 d5b7e3d5c3ba5319656677733d85eb96 845 Gene3D G3DSA:3.40.50.980 272 442 8.3E-45 T 09-03-2017 TK78_RS19250 d5b7e3d5c3ba5319656677733d85eb96 845 Pfam PF13193 AMP-binding enzyme C-terminal domain 681 756 3.4E-14 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS19250 d5b7e3d5c3ba5319656677733d85eb96 845 Gene3D G3DSA:3.30.300.30 668 784 9.5E-41 T 09-03-2017 TK78_RS19250 d5b7e3d5c3ba5319656677733d85eb96 845 Pfam PF00550 Phosphopantetheine attachment site 781 845 3.3E-17 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS19250 d5b7e3d5c3ba5319656677733d85eb96 845 Gene3D G3DSA:1.10.1200.10 785 845 5.0E-27 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS19250 d5b7e3d5c3ba5319656677733d85eb96 845 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 299 697 2.5E-116 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS19250 d5b7e3d5c3ba5319656677733d85eb96 845 SUPERFAMILY SSF56801 237 793 6.15E-142 T 09-03-2017 TK78_RS19250 d5b7e3d5c3ba5319656677733d85eb96 845 SMART SM00823 Phosphopantetheine attachment site 780 845 2.1E-9 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS19250 d5b7e3d5c3ba5319656677733d85eb96 845 Gene3D G3DSA:3.40.50.980 454 584 7.7E-26 T 09-03-2017 TK78_RS19250 d5b7e3d5c3ba5319656677733d85eb96 845 SUPERFAMILY SSF47336 775 845 5.1E-21 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS19250 d5b7e3d5c3ba5319656677733d85eb96 845 Gene3D G3DSA:2.30.38.10 585 663 4.0E-25 T 09-03-2017 TK78_RS26115 8ce8a319a4b400eccdf7597feeadc9c7 271 Pfam PF02274 Amidinotransferase 32 270 1.0E-10 T 09-03-2017 TK78_RS26115 8ce8a319a4b400eccdf7597feeadc9c7 271 Gene3D G3DSA:3.75.10.10 7 269 1.7E-57 T 09-03-2017 TK78_RS26115 8ce8a319a4b400eccdf7597feeadc9c7 271 SUPERFAMILY SSF55909 7 270 6.48E-50 T 09-03-2017 TK78_RS04260 48bbd07d99f09a4abca9ad9d80f0505e 749 SUPERFAMILY SSF53822 401 743 1.35E-56 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS04260 48bbd07d99f09a4abca9ad9d80f0505e 749 SUPERFAMILY SSF56112 13 261 2.29E-61 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS04260 48bbd07d99f09a4abca9ad9d80f0505e 749 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 133 145 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS04260 48bbd07d99f09a4abca9ad9d80f0505e 749 Pfam PF00069 Protein kinase domain 15 261 1.1E-35 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS04260 48bbd07d99f09a4abca9ad9d80f0505e 749 Gene3D G3DSA:3.40.50.2300 401 507 1.2E-29 T 09-03-2017 TK78_RS04260 48bbd07d99f09a4abca9ad9d80f0505e 749 Gene3D G3DSA:3.40.50.2300 656 720 1.2E-29 T 09-03-2017 TK78_RS04260 48bbd07d99f09a4abca9ad9d80f0505e 749 Pfam PF13458 Periplasmic binding protein 402 737 3.3E-44 T 09-03-2017 IPR028081 Leucine-binding protein domain TK78_RS04260 48bbd07d99f09a4abca9ad9d80f0505e 749 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 21 43 - T 09-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 TK78_RS04260 48bbd07d99f09a4abca9ad9d80f0505e 749 Gene3D G3DSA:1.10.510.10 122 263 4.4E-35 T 09-03-2017 TK78_RS04260 48bbd07d99f09a4abca9ad9d80f0505e 749 Gene3D G3DSA:3.20.20.70 508 636 8.2E-4 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS04260 48bbd07d99f09a4abca9ad9d80f0505e 749 Gene3D G3DSA:3.30.200.20 7 121 8.8E-16 T 09-03-2017 TK78_RS04260 48bbd07d99f09a4abca9ad9d80f0505e 749 SMART SM00220 15 264 5.1E-45 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS01950 bf1a980d94fa8d2efed986c43f2244af 326 SUPERFAMILY SSF56300 28 156 3.65E-25 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS01950 bf1a980d94fa8d2efed986c43f2244af 326 SUPERFAMILY SSF56300 196 287 3.65E-25 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS01950 bf1a980d94fa8d2efed986c43f2244af 326 Pfam PF00149 Calcineurin-like phosphoesterase 30 264 1.8E-16 T 09-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 TK78_RS01950 bf1a980d94fa8d2efed986c43f2244af 326 Gene3D G3DSA:3.60.21.10 30 95 1.3E-21 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS01950 bf1a980d94fa8d2efed986c43f2244af 326 Gene3D G3DSA:3.60.21.10 204 288 1.3E-21 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS14290 53a6eff9e2fb78c5157f2f345e4385d5 372 PIRSF PIRSF000525 1 372 2.3E-74 T 09-03-2017 IPR022278 Phosphoserine aminotransferase GO:0004648|GO:0006564 KEGG: 00260+2.6.1.52|KEGG: 00680+2.6.1.52|KEGG: 00750+2.6.1.52|Reactome: R-HSA-977347 TK78_RS14290 53a6eff9e2fb78c5157f2f345e4385d5 372 TIGRFAM TIGR01366 serC_3: putative phosphoserine aminotransferase 11 372 1.4E-212 T 09-03-2017 IPR006272 Phosphoserine aminotransferase, Mycobacterial-type GO:0004648|GO:0006564|GO:0009058 KEGG: 00260+2.6.1.52|KEGG: 00680+2.6.1.52|KEGG: 00750+2.6.1.52 TK78_RS14290 53a6eff9e2fb78c5157f2f345e4385d5 372 Hamap MF_00160 Phosphoserine aminotransferase [serC]. 5 372 23.747 T 09-03-2017 IPR022278 Phosphoserine aminotransferase GO:0004648|GO:0006564 KEGG: 00260+2.6.1.52|KEGG: 00680+2.6.1.52|KEGG: 00750+2.6.1.52|Reactome: R-HSA-977347 TK78_RS14290 53a6eff9e2fb78c5157f2f345e4385d5 372 Pfam PF00266 Aminotransferase class-V 137 331 1.1E-16 T 09-03-2017 IPR000192 Aminotransferase class V domain TK78_RS14290 53a6eff9e2fb78c5157f2f345e4385d5 372 Gene3D G3DSA:3.40.640.10 20 267 6.3E-52 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS14290 53a6eff9e2fb78c5157f2f345e4385d5 372 SUPERFAMILY SSF53383 12 371 4.83E-77 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS24125 572111ecd087347c6c4c7855ff70d6dc 344 ProSitePatterns PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 113 126 - T 09-03-2017 IPR018313 Solute-binding protein family 3, conserved site GO:0005215|GO:0006810 TK78_RS24125 572111ecd087347c6c4c7855ff70d6dc 344 SUPERFAMILY SSF53850 79 325 3.18E-51 T 09-03-2017 TK78_RS24125 572111ecd087347c6c4c7855ff70d6dc 344 SMART SM00062 89 329 2.8E-42 T 09-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF TK78_RS24125 572111ecd087347c6c4c7855ff70d6dc 344 Gene3D G3DSA:3.40.190.10 172 286 3.5E-17 T 09-03-2017 TK78_RS24125 572111ecd087347c6c4c7855ff70d6dc 344 Gene3D G3DSA:3.40.190.10 85 171 8.8E-27 T 09-03-2017 TK78_RS24125 572111ecd087347c6c4c7855ff70d6dc 344 Gene3D G3DSA:3.40.190.10 287 327 8.8E-27 T 09-03-2017 TK78_RS24125 572111ecd087347c6c4c7855ff70d6dc 344 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3 90 326 9.7E-45 T 09-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF TK78_RS06470 dfc6ea6041b1ba408fa274991942a360 265 ProSitePatterns PS00894 DeoR-type HTH domain signature. 6 40 - T 09-03-2017 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 TK78_RS06470 dfc6ea6041b1ba408fa274991942a360 265 SMART SM01134 72 246 2.0E-58 T 09-03-2017 TK78_RS06470 dfc6ea6041b1ba408fa274991942a360 265 SMART SM00420 6 58 8.3E-18 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS06470 dfc6ea6041b1ba408fa274991942a360 265 SUPERFAMILY SSF46785 4 62 3.67E-11 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS06470 dfc6ea6041b1ba408fa274991942a360 265 Gene3D G3DSA:1.10.10.10 2 55 1.6E-7 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS06470 dfc6ea6041b1ba408fa274991942a360 265 Pfam PF08220 DeoR-like helix-turn-helix domain 6 58 3.6E-17 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS06470 dfc6ea6041b1ba408fa274991942a360 265 Gene3D G3DSA:3.40.50.1360 77 228 1.4E-14 T 09-03-2017 TK78_RS06470 dfc6ea6041b1ba408fa274991942a360 265 SUPERFAMILY SSF100950 75 246 2.79E-25 T 09-03-2017 TK78_RS06470 dfc6ea6041b1ba408fa274991942a360 265 Pfam PF00455 DeoR C terminal sensor domain 74 245 1.4E-45 T 09-03-2017 IPR014036 DeoR C-terminal sensor domain TK78_RS06470 dfc6ea6041b1ba408fa274991942a360 265 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 24 38 1.1E-8 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS06470 dfc6ea6041b1ba408fa274991942a360 265 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 38 56 1.1E-8 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS13210 a0e41c2799cf2c613b8f5763b914b45c 123 TIGRFAM TIGR00981 rpsL_bact: ribosomal protein uS12 2 123 2.9E-68 T 09-03-2017 IPR005679 Ribosomal protein S12, bacterial-type GO:0003735|GO:0006412|GO:0015935 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13210 a0e41c2799cf2c613b8f5763b914b45c 123 PIRSF PIRSF002133 1 123 8.4E-55 T 09-03-2017 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13210 a0e41c2799cf2c613b8f5763b914b45c 123 PRINTS PR01034 Ribosomal protein S12 signature 58 77 8.4E-59 T 09-03-2017 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13210 a0e41c2799cf2c613b8f5763b914b45c 123 PRINTS PR01034 Ribosomal protein S12 signature 110 122 8.4E-59 T 09-03-2017 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13210 a0e41c2799cf2c613b8f5763b914b45c 123 PRINTS PR01034 Ribosomal protein S12 signature 94 110 8.4E-59 T 09-03-2017 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13210 a0e41c2799cf2c613b8f5763b914b45c 123 PRINTS PR01034 Ribosomal protein S12 signature 42 57 8.4E-59 T 09-03-2017 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13210 a0e41c2799cf2c613b8f5763b914b45c 123 PRINTS PR01034 Ribosomal protein S12 signature 77 94 8.4E-59 T 09-03-2017 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13210 a0e41c2799cf2c613b8f5763b914b45c 123 PRINTS PR01034 Ribosomal protein S12 signature 27 42 8.4E-59 T 09-03-2017 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13210 a0e41c2799cf2c613b8f5763b914b45c 123 ProSitePatterns PS00055 Ribosomal protein S12 signature. 43 50 - T 09-03-2017 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13210 a0e41c2799cf2c613b8f5763b914b45c 123 Gene3D G3DSA:2.40.50.140 2 123 3.3E-65 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS13210 a0e41c2799cf2c613b8f5763b914b45c 123 Pfam PF00164 Ribosomal protein S12/S23 3 123 1.5E-44 T 09-03-2017 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13210 a0e41c2799cf2c613b8f5763b914b45c 123 SUPERFAMILY SSF50249 2 123 6.77E-53 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS13210 a0e41c2799cf2c613b8f5763b914b45c 123 Hamap MF_00403_B 30S ribosomal protein S12 [rpsL]. 1 123 39.977 T 09-03-2017 IPR005679 Ribosomal protein S12, bacterial-type GO:0003735|GO:0006412|GO:0015935 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS16615 5fcc0e9aa4f89e126fc80af316f50442 272 Pfam PF04264 YceI-like domain 97 263 1.2E-39 T 09-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like TK78_RS16615 5fcc0e9aa4f89e126fc80af316f50442 272 SMART SM00867 96 264 1.9E-63 T 09-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like TK78_RS16615 5fcc0e9aa4f89e126fc80af316f50442 272 Gene3D G3DSA:2.40.128.110 96 268 4.6E-57 T 09-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like TK78_RS16615 5fcc0e9aa4f89e126fc80af316f50442 272 SUPERFAMILY SSF49464 6 73 4.71E-7 T 09-03-2017 IPR008969 Carboxypeptidase-like, regulatory domain TK78_RS16615 5fcc0e9aa4f89e126fc80af316f50442 272 SUPERFAMILY SSF101874 95 266 4.45E-52 T 09-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like TK78_RS16615 5fcc0e9aa4f89e126fc80af316f50442 272 Gene3D G3DSA:2.60.40.1120 3 86 2.0E-7 T 09-03-2017 IPR014766 Carboxypeptidase, regulatory domain TK78_RS27280 56d5ee0ef86071f8fc106e925877fb37 251 SUPERFAMILY SSF51366 3 251 4.16E-84 T 09-03-2017 IPR011060 Ribulose-phosphate binding barrel GO:0003824|GO:0008152 TK78_RS27280 56d5ee0ef86071f8fc106e925877fb37 251 Pfam PF00977 Histidine biosynthesis protein 6 234 1.1E-87 T 09-03-2017 IPR006062 Histidine biosynthesis GO:0000105 TK78_RS27280 56d5ee0ef86071f8fc106e925877fb37 251 TIGRFAM TIGR00735 hisF: imidazoleglycerol phosphate synthase, cyclase subunit 3 251 2.5E-108 T 09-03-2017 IPR004651 Histidine biosynthesis, HisF GO:0000105|GO:0000107|GO:0005737 TK78_RS27280 56d5ee0ef86071f8fc106e925877fb37 251 Hamap MF_01013 Imidazole glycerol phosphate synthase subunit HisF [hisF]. 2 251 47.477 T 09-03-2017 IPR004651 Histidine biosynthesis, HisF GO:0000105|GO:0000107|GO:0005737 TK78_RS27280 56d5ee0ef86071f8fc106e925877fb37 251 Gene3D G3DSA:3.20.20.70 6 251 5.4E-103 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS03325 ccdb0ee5edbd71e36e2feedfe6a0c37e 380 ProSitePatterns PS00073 Acyl-CoA dehydrogenases signature 2. 337 356 - T 09-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 TK78_RS03325 ccdb0ee5edbd71e36e2feedfe6a0c37e 380 Gene3D G3DSA:1.20.140.10 219 379 5.2E-55 T 09-03-2017 TK78_RS03325 ccdb0ee5edbd71e36e2feedfe6a0c37e 380 Gene3D G3DSA:2.40.110.10 123 218 7.3E-41 T 09-03-2017 TK78_RS03325 ccdb0ee5edbd71e36e2feedfe6a0c37e 380 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 7 119 7.5E-34 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS03325 ccdb0ee5edbd71e36e2feedfe6a0c37e 380 ProSitePatterns PS00072 Acyl-CoA dehydrogenases signature 1. 125 137 - T 09-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 TK78_RS03325 ccdb0ee5edbd71e36e2feedfe6a0c37e 380 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 123 218 6.3E-26 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS03325 ccdb0ee5edbd71e36e2feedfe6a0c37e 380 SUPERFAMILY SSF56645 5 242 1.26E-83 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS03325 ccdb0ee5edbd71e36e2feedfe6a0c37e 380 SUPERFAMILY SSF47203 233 379 4.19E-44 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS03325 ccdb0ee5edbd71e36e2feedfe6a0c37e 380 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 236 379 6.2E-40 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS03325 ccdb0ee5edbd71e36e2feedfe6a0c37e 380 Gene3D G3DSA:1.10.540.10 6 120 3.3E-35 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS18760 557e57b2ef28d4fa79ec31fb64230d08 331 Gene3D G3DSA:1.10.10.60 228 276 1.1E-15 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS18760 557e57b2ef28d4fa79ec31fb64230d08 331 SMART SM00342 239 322 6.1E-28 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS18760 557e57b2ef28d4fa79ec31fb64230d08 331 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 276 318 - T 09-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 TK78_RS18760 557e57b2ef28d4fa79ec31fb64230d08 331 Pfam PF01965 DJ-1/PfpI family 8 184 1.5E-23 T 09-03-2017 IPR002818 DJ-1/PfpI TK78_RS18760 557e57b2ef28d4fa79ec31fb64230d08 331 Gene3D G3DSA:1.10.10.60 277 326 2.3E-12 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS18760 557e57b2ef28d4fa79ec31fb64230d08 331 SUPERFAMILY SSF52317 8 204 1.02E-46 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS18760 557e57b2ef28d4fa79ec31fb64230d08 331 SUPERFAMILY SSF46689 223 272 2.11E-9 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS18760 557e57b2ef28d4fa79ec31fb64230d08 331 Gene3D G3DSA:3.40.50.880 8 227 6.7E-54 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS18760 557e57b2ef28d4fa79ec31fb64230d08 331 Pfam PF12833 Helix-turn-helix domain 245 324 1.1E-23 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS18760 557e57b2ef28d4fa79ec31fb64230d08 331 SUPERFAMILY SSF46689 275 326 1.36E-10 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS16630 8c750bf595399666ab0e8bd859426691 244 SUPERFAMILY SSF48498 81 238 2.33E-28 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS16630 8c750bf595399666ab0e8bd859426691 244 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 82 234 3.9E-16 T 09-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 TK78_RS16630 8c750bf595399666ab0e8bd859426691 244 Pfam PF00440 Bacterial regulatory proteins, tetR family 25 69 3.4E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS16630 8c750bf595399666ab0e8bd859426691 244 Gene3D G3DSA:1.10.357.10 11 239 6.7E-63 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS16630 8c750bf595399666ab0e8bd859426691 244 SUPERFAMILY SSF46689 15 81 4.31E-13 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS00495 a265d5fd2611f976ff8392bed9ebcf77 659 Gene3D G3DSA:3.20.20.300 7 376 3.5E-92 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS00495 a265d5fd2611f976ff8392bed9ebcf77 659 PRINTS PR00133 Glycosyl hydrolase family 3 signature 178 194 4.0E-22 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS00495 a265d5fd2611f976ff8392bed9ebcf77 659 PRINTS PR00133 Glycosyl hydrolase family 3 signature 132 151 4.0E-22 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS00495 a265d5fd2611f976ff8392bed9ebcf77 659 PRINTS PR00133 Glycosyl hydrolase family 3 signature 287 305 4.0E-22 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS00495 a265d5fd2611f976ff8392bed9ebcf77 659 PRINTS PR00133 Glycosyl hydrolase family 3 signature 109 125 4.0E-22 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS00495 a265d5fd2611f976ff8392bed9ebcf77 659 PRINTS PR00133 Glycosyl hydrolase family 3 signature 217 233 4.0E-22 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS00495 a265d5fd2611f976ff8392bed9ebcf77 659 SUPERFAMILY SSF52279 397 642 3.53E-42 T 09-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 TK78_RS00495 a265d5fd2611f976ff8392bed9ebcf77 659 Pfam PF01915 Glycosyl hydrolase family 3 C-terminal domain 396 640 1.5E-45 T 09-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 TK78_RS00495 a265d5fd2611f976ff8392bed9ebcf77 659 SUPERFAMILY SSF51445 6 45 2.53E-84 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS00495 a265d5fd2611f976ff8392bed9ebcf77 659 SUPERFAMILY SSF51445 73 379 2.53E-84 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS00495 a265d5fd2611f976ff8392bed9ebcf77 659 Pfam PF00933 Glycosyl hydrolase family 3 N terminal domain 27 362 1.0E-52 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS00495 a265d5fd2611f976ff8392bed9ebcf77 659 Gene3D G3DSA:3.40.50.1700 386 642 9.1E-62 T 09-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 TK78_RS00935 f6f139473fed43cef37edb462bae5043 710 Pfam PF08447 PAS fold 50 137 1.5E-11 T 09-03-2017 IPR013655 PAS fold-3 GO:0005515 TK78_RS00935 f6f139473fed43cef37edb462bae5043 710 SUPERFAMILY SSF55781 192 328 9.38E-13 T 09-03-2017 IPR029016 GAF domain-like TK78_RS00935 f6f139473fed43cef37edb462bae5043 710 Gene3D G3DSA:3.30.450.20 38 140 3.9E-15 T 09-03-2017 TK78_RS00935 f6f139473fed43cef37edb462bae5043 710 SMART SM00331 344 561 1.1E-35 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS00935 f6f139473fed43cef37edb462bae5043 710 SUPERFAMILY SSF81606 359 560 7.06E-9 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS00935 f6f139473fed43cef37edb462bae5043 710 Gene3D G3DSA:3.30.450.40 155 332 2.2E-12 T 09-03-2017 IPR029016 GAF domain-like TK78_RS00935 f6f139473fed43cef37edb462bae5043 710 SUPERFAMILY SSF55785 37 141 4.89E-12 T 09-03-2017 IPR000014 PAS domain TK78_RS00935 f6f139473fed43cef37edb462bae5043 710 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 374 561 5.8E-45 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS01145 88d7959d88e8f391f2df1e7e375a9dc3 955 Pfam PF13191 AAA ATPase domain 16 174 1.8E-14 T 09-03-2017 TK78_RS01145 88d7959d88e8f391f2df1e7e375a9dc3 955 SUPERFAMILY SSF46894 891 949 4.08E-17 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS01145 88d7959d88e8f391f2df1e7e375a9dc3 955 Pfam PF00196 Bacterial regulatory proteins, luxR family 898 949 3.4E-15 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS01145 88d7959d88e8f391f2df1e7e375a9dc3 955 SMART SM00421 896 953 1.6E-21 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS01145 88d7959d88e8f391f2df1e7e375a9dc3 955 ProSitePatterns PS00622 LuxR-type HTH domain signature. 913 940 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS01145 88d7959d88e8f391f2df1e7e375a9dc3 955 Gene3D G3DSA:1.10.10.10 898 949 4.6E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS01145 88d7959d88e8f391f2df1e7e375a9dc3 955 Gene3D G3DSA:1.25.40.10 552 779 4.4E-8 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS01145 88d7959d88e8f391f2df1e7e375a9dc3 955 SUPERFAMILY SSF52540 142 256 1.36E-5 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01145 88d7959d88e8f391f2df1e7e375a9dc3 955 SUPERFAMILY SSF52540 28 84 1.36E-5 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01145 88d7959d88e8f391f2df1e7e375a9dc3 955 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 899 913 2.0E-9 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS01145 88d7959d88e8f391f2df1e7e375a9dc3 955 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 929 941 2.0E-9 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS01145 88d7959d88e8f391f2df1e7e375a9dc3 955 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 913 929 2.0E-9 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS17530 3f04e84585be8c1359917bbcfc59a2fe 172 Pfam PF00498 FHA domain 99 164 1.6E-15 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS17530 3f04e84585be8c1359917bbcfc59a2fe 172 SUPERFAMILY SSF49879 48 171 3.06E-28 T 09-03-2017 IPR008984 SMAD/FHA domain GO:0005515 TK78_RS17530 3f04e84585be8c1359917bbcfc59a2fe 172 SMART SM00240 98 149 1.1E-12 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS17530 3f04e84585be8c1359917bbcfc59a2fe 172 Gene3D G3DSA:2.60.200.20 78 171 3.2E-27 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS25870 a253f595707488421adc3caf8b0f3b91 287 Gene3D G3DSA:3.30.930.10 130 266 4.8E-6 T 09-03-2017 TK78_RS25870 a253f595707488421adc3caf8b0f3b91 287 SUPERFAMILY SSF55681 15 274 7.17E-18 T 09-03-2017 TK78_RS04355 06a7337c528b9303e4aa4ec021374f82 602 Gene3D G3DSA:3.50.50.60 241 280 3.6E-6 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS04355 06a7337c528b9303e4aa4ec021374f82 602 Gene3D G3DSA:3.50.50.60 388 438 3.6E-6 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS04355 06a7337c528b9303e4aa4ec021374f82 602 Gene3D G3DSA:3.50.50.60 64 240 5.6E-57 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS04355 06a7337c528b9303e4aa4ec021374f82 602 Gene3D G3DSA:3.50.50.60 483 590 5.6E-57 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS04355 06a7337c528b9303e4aa4ec021374f82 602 SUPERFAMILY SSF51905 392 517 1.39E-43 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS04355 06a7337c528b9303e4aa4ec021374f82 602 SUPERFAMILY SSF51905 65 273 1.39E-43 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS04355 06a7337c528b9303e4aa4ec021374f82 602 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 65 261 4.9E-10 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS28830 6fcf7bbbe706bdc56f723360d815856f 358 Pfam PF00296 Luciferase-like monooxygenase 14 253 1.2E-34 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS28830 6fcf7bbbe706bdc56f723360d815856f 358 SUPERFAMILY SSF51679 12 344 8.51E-75 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS28830 6fcf7bbbe706bdc56f723360d815856f 358 Gene3D G3DSA:3.20.20.30 12 345 3.0E-92 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS04335 4b1b08adf6b439b1a82a2b7b10a37e1f 265 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 160 179 2.8E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04335 4b1b08adf6b439b1a82a2b7b10a37e1f 265 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 87 98 2.8E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04335 4b1b08adf6b439b1a82a2b7b10a37e1f 265 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 140 148 2.8E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04335 4b1b08adf6b439b1a82a2b7b10a37e1f 265 SUPERFAMILY SSF51735 22 262 3.42E-70 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS04335 4b1b08adf6b439b1a82a2b7b10a37e1f 265 Gene3D G3DSA:3.40.50.720 20 264 1.2E-71 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS04335 4b1b08adf6b439b1a82a2b7b10a37e1f 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 25 42 2.9E-35 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04335 4b1b08adf6b439b1a82a2b7b10a37e1f 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 160 179 2.9E-35 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04335 4b1b08adf6b439b1a82a2b7b10a37e1f 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 226 246 2.9E-35 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04335 4b1b08adf6b439b1a82a2b7b10a37e1f 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 87 98 2.9E-35 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04335 4b1b08adf6b439b1a82a2b7b10a37e1f 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 134 150 2.9E-35 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04335 4b1b08adf6b439b1a82a2b7b10a37e1f 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 181 198 2.9E-35 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04335 4b1b08adf6b439b1a82a2b7b10a37e1f 265 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 33 262 6.3E-46 T 09-03-2017 TK78_RS04335 4b1b08adf6b439b1a82a2b7b10a37e1f 265 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 147 175 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS01240 12cdef261c7c7f2d9fc473b9e6d3b58f 571 SUPERFAMILY SSF90123 19 336 6.54E-48 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS01240 12cdef261c7c7f2d9fc473b9e6d3b58f 571 Pfam PF00664 ABC transporter transmembrane region 37 299 5.8E-24 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS01240 12cdef261c7c7f2d9fc473b9e6d3b58f 571 SUPERFAMILY SSF52540 341 555 7.23E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01240 12cdef261c7c7f2d9fc473b9e6d3b58f 571 Pfam PF00005 ABC transporter 363 509 2.8E-28 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS01240 12cdef261c7c7f2d9fc473b9e6d3b58f 571 SMART SM00382 371 571 1.7E-17 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS01240 12cdef261c7c7f2d9fc473b9e6d3b58f 571 Gene3D G3DSA:1.20.1560.10 21 333 1.7E-42 T 09-03-2017 TK78_RS01240 12cdef261c7c7f2d9fc473b9e6d3b58f 571 Gene3D G3DSA:3.40.50.300 349 556 1.0E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01240 12cdef261c7c7f2d9fc473b9e6d3b58f 571 ProSitePatterns PS00211 ABC transporters family signature. 482 496 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS20485 9653e63ad96d46e60abb1ae820715566 242 Gene3D G3DSA:3.40.50.80 118 241 5.5E-28 T 09-03-2017 TK78_RS20485 9653e63ad96d46e60abb1ae820715566 242 Pfam PF04954 Siderophore-interacting protein 124 241 1.7E-21 T 09-03-2017 IPR007037 Siderophore-interacting protein TK78_RS20485 9653e63ad96d46e60abb1ae820715566 242 SUPERFAMILY SSF63380 17 115 1.32E-10 T 09-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 TK78_RS20485 9653e63ad96d46e60abb1ae820715566 242 Gene3D G3DSA:2.40.30.10 16 108 3.0E-20 T 09-03-2017 TK78_RS20485 9653e63ad96d46e60abb1ae820715566 242 Pfam PF08021 Siderophore-interacting FAD-binding domain 53 107 1.8E-9 T 09-03-2017 IPR013113 FAD-binding 9, siderophore-interacting TK78_RS01375 2c5cda9dc9efa0801925105c3443952d 492 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 3 22 8.3E-5 T 09-03-2017 TK78_RS01375 2c5cda9dc9efa0801925105c3443952d 492 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 271 287 8.3E-5 T 09-03-2017 TK78_RS01375 2c5cda9dc9efa0801925105c3443952d 492 SUPERFAMILY SSF54373 308 436 1.67E-44 T 09-03-2017 TK78_RS01375 2c5cda9dc9efa0801925105c3443952d 492 SUPERFAMILY SSF51905 2 304 2.7E-37 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS01375 2c5cda9dc9efa0801925105c3443952d 492 SUPERFAMILY SSF51905 433 490 2.7E-37 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS01375 2c5cda9dc9efa0801925105c3443952d 492 Pfam PF05199 GMC oxidoreductase 431 482 5.0E-11 T 09-03-2017 IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal GO:0016614|GO:0055114 Reactome: R-HSA-6798163 TK78_RS01375 2c5cda9dc9efa0801925105c3443952d 492 Gene3D G3DSA:3.30.410.10 312 427 4.0E-75 T 09-03-2017 TK78_RS01375 2c5cda9dc9efa0801925105c3443952d 492 Gene3D G3DSA:3.30.410.10 146 203 4.0E-75 T 09-03-2017 TK78_RS01375 2c5cda9dc9efa0801925105c3443952d 492 Gene3D G3DSA:3.50.50.60 2 142 6.1E-67 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS01375 2c5cda9dc9efa0801925105c3443952d 492 Gene3D G3DSA:3.50.50.60 205 311 6.1E-67 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS01375 2c5cda9dc9efa0801925105c3443952d 492 Gene3D G3DSA:3.50.50.60 428 489 6.1E-67 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS06735 6e07fd296c324bb911aef0d12271e4bb 296 Gene3D G3DSA:3.40.50.300 2 212 1.5E-45 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06735 6e07fd296c324bb911aef0d12271e4bb 296 SMART SM00382 27 206 1.1E-11 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS06735 6e07fd296c324bb911aef0d12271e4bb 296 SUPERFAMILY SSF52540 2 211 3.55E-44 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06735 6e07fd296c324bb911aef0d12271e4bb 296 ProSitePatterns PS00211 ABC transporters family signature. 123 137 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS06735 6e07fd296c324bb911aef0d12271e4bb 296 Pfam PF00005 ABC transporter 18 150 1.6E-20 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS03445 e3a5d5411d6b6a10ab7aa3fb479f5f49 422 PRINTS PR01217 Proline rich extensin signature 347 359 1.1E-13 T 09-03-2017 TK78_RS03445 e3a5d5411d6b6a10ab7aa3fb479f5f49 422 PRINTS PR01217 Proline rich extensin signature 324 340 1.1E-13 T 09-03-2017 TK78_RS03445 e3a5d5411d6b6a10ab7aa3fb479f5f49 422 PRINTS PR01217 Proline rich extensin signature 360 381 1.1E-13 T 09-03-2017 TK78_RS03445 e3a5d5411d6b6a10ab7aa3fb479f5f49 422 PRINTS PR01217 Proline rich extensin signature 384 400 1.1E-13 T 09-03-2017 TK78_RS03445 e3a5d5411d6b6a10ab7aa3fb479f5f49 422 PRINTS PR01217 Proline rich extensin signature 306 318 1.1E-13 T 09-03-2017 TK78_RS03445 e3a5d5411d6b6a10ab7aa3fb479f5f49 422 SUPERFAMILY SSF53955 90 259 4.84E-39 T 09-03-2017 IPR023346 Lysozyme-like domain TK78_RS03445 e3a5d5411d6b6a10ab7aa3fb479f5f49 422 Pfam PF13406 Transglycosylase SLT domain 179 219 4.9E-7 T 09-03-2017 IPR031304 Transglycosylase SLT domain 2 TK78_RS03445 e3a5d5411d6b6a10ab7aa3fb479f5f49 422 Gene3D G3DSA:1.10.530.10 116 242 2.3E-9 T 09-03-2017 TK78_RS06065 01d8ccaa6e7517b86a39e25642d16a35 243 SUPERFAMILY SSF53474 4 235 4.57E-47 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS06065 01d8ccaa6e7517b86a39e25642d16a35 243 PRINTS PR00111 Alpha/beta hydrolase fold signature 32 47 5.1E-10 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS06065 01d8ccaa6e7517b86a39e25642d16a35 243 PRINTS PR00111 Alpha/beta hydrolase fold signature 74 87 5.1E-10 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS06065 01d8ccaa6e7517b86a39e25642d16a35 243 PRINTS PR00111 Alpha/beta hydrolase fold signature 183 197 5.1E-10 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS06065 01d8ccaa6e7517b86a39e25642d16a35 243 PRINTS PR00111 Alpha/beta hydrolase fold signature 88 101 5.1E-10 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS06065 01d8ccaa6e7517b86a39e25642d16a35 243 Pfam PF12697 Alpha/beta hydrolase family 9 228 2.8E-25 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS06065 01d8ccaa6e7517b86a39e25642d16a35 243 Gene3D G3DSA:3.40.50.1820 4 235 5.5E-48 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS11065 5f7d73a5db0788d7c27b74daf5662672 282 Pfam PF13560 Helix-turn-helix domain 16 74 2.3E-12 T 09-03-2017 TK78_RS11065 5f7d73a5db0788d7c27b74daf5662672 282 Gene3D G3DSA:1.10.260.40 6 70 1.2E-10 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS11065 5f7d73a5db0788d7c27b74daf5662672 282 SUPERFAMILY SSF47413 10 70 1.2E-5 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS23190 8157a84c4f19976ad571e2863ef054a3 550 TIGRFAM TIGR03801 asp_4_decarbox: aspartate 4-decarboxylase 17 545 3.3E-223 T 09-03-2017 IPR022518 Aspartate 4-decarboxylase KEGG: 00220+2.6.1.1|KEGG: 00250+4.1.1.12+2.6.1.1|KEGG: 00270+4.1.1.12+2.6.1.1|KEGG: 00330+2.6.1.1|KEGG: 00350+2.6.1.1|KEGG: 00360+2.6.1.1|KEGG: 00400+2.6.1.1|KEGG: 00401+2.6.1.1|KEGG: 00710+2.6.1.1|KEGG: 00950+2.6.1.1|KEGG: 00960+2.6.1.1|MetaCyc: PWY-5913|MetaCyc: PWY-6318|MetaCyc: PWY-6638|MetaCyc: PWY-6642|MetaCyc: PWY-6643|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7383 TK78_RS23190 8157a84c4f19976ad571e2863ef054a3 550 Pfam PF00155 Aminotransferase class I and II 187 398 4.7E-17 T 09-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TK78_RS23190 8157a84c4f19976ad571e2863ef054a3 550 ProSitePatterns PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 331 344 - T 09-03-2017 IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding site GO:0003824|GO:0009058|GO:0030170 TK78_RS23190 8157a84c4f19976ad571e2863ef054a3 550 Gene3D G3DSA:3.40.640.10 137 362 2.8E-32 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS23190 8157a84c4f19976ad571e2863ef054a3 550 SUPERFAMILY SSF53383 145 357 1.53E-41 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS23190 8157a84c4f19976ad571e2863ef054a3 550 SUPERFAMILY SSF53383 394 528 1.53E-41 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS23190 8157a84c4f19976ad571e2863ef054a3 550 Gene3D G3DSA:3.90.1150.10 401 538 3.9E-11 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS06545 7a2cd98b0f17b193716a4672dd6480f2 447 SUPERFAMILY SSF46785 5 70 1.48E-13 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS06545 7a2cd98b0f17b193716a4672dd6480f2 447 SUPERFAMILY SSF53383 110 437 6.12E-57 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS06545 7a2cd98b0f17b193716a4672dd6480f2 447 SMART SM00345 7 66 3.3E-10 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS06545 7a2cd98b0f17b193716a4672dd6480f2 447 Gene3D G3DSA:3.40.640.10 117 330 6.2E-39 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS06545 7a2cd98b0f17b193716a4672dd6480f2 447 Pfam PF00392 Bacterial regulatory proteins, gntR family 6 66 1.2E-9 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS06545 7a2cd98b0f17b193716a4672dd6480f2 447 Gene3D G3DSA:1.10.10.10 5 67 2.8E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS06545 7a2cd98b0f17b193716a4672dd6480f2 447 Pfam PF00155 Aminotransferase class I and II 107 430 3.8E-10 T 09-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TK78_RS21590 d37154d80f396cf32297a1ec810275d7 319 Pfam PF02541 Ppx/GppA phosphatase family 25 309 1.4E-57 T 09-03-2017 IPR003695 Ppx/GppA phosphatase KEGG: 00230+3.6.1.40 TK78_RS21590 d37154d80f396cf32297a1ec810275d7 319 SUPERFAMILY SSF53067 3 124 5.7E-33 T 09-03-2017 TK78_RS21590 d37154d80f396cf32297a1ec810275d7 319 Gene3D G3DSA:3.30.420.40 1 125 2.8E-50 T 09-03-2017 TK78_RS21590 d37154d80f396cf32297a1ec810275d7 319 SUPERFAMILY SSF53067 134 312 2.73E-39 T 09-03-2017 TK78_RS21590 d37154d80f396cf32297a1ec810275d7 319 Gene3D G3DSA:3.30.420.150 133 313 5.7E-59 T 09-03-2017 TK78_RS34030 1decbf1bede4816cbd51988d30573ebb 384 Gene3D G3DSA:3.40.50.150 206 383 9.1E-22 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS34030 1decbf1bede4816cbd51988d30573ebb 384 ProSitePatterns PS00092 N-6 Adenine-specific DNA methylases signature. 312 318 - T 09-03-2017 IPR002052 DNA methylase, N-6 adenine-specific, conserved site GO:0003676|GO:0008168|GO:0032259 TK78_RS34030 1decbf1bede4816cbd51988d30573ebb 384 SUPERFAMILY SSF53335 217 358 2.86E-24 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS34030 1decbf1bede4816cbd51988d30573ebb 384 PIRSF PIRSF037565 1 384 3.0E-135 T 09-03-2017 IPR017237 rRNA (guanine-N2-)-methyltransferase, RsmD GO:0005737|GO:0008990|GO:0031167 KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 TK78_RS34030 1decbf1bede4816cbd51988d30573ebb 384 Pfam PF05175 Methyltransferase small domain 209 380 9.2E-52 T 09-03-2017 IPR007848 Methyltransferase small domain GO:0008168 TK78_RS34030 1decbf1bede4816cbd51988d30573ebb 384 Hamap MF_01859 Ribosomal RNA large subunit methyltransferase G [rlmG]. 1 383 45.553 T 09-03-2017 IPR017237 rRNA (guanine-N2-)-methyltransferase, RsmD GO:0005737|GO:0008990|GO:0031167 KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 TK78_RS27935 dc920d8b36ce988a8cb6a221e91ac81e 372 Gene3D G3DSA:3.20.20.70 1 359 8.9E-126 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS27935 dc920d8b36ce988a8cb6a221e91ac81e 372 Pfam PF00923 Transaldolase 15 359 1.0E-83 T 09-03-2017 IPR001585 Transaldolase/Fructose-6-phosphate aldolase GO:0005975 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723|Reactome: R-HSA-163754|Reactome: R-HSA-6791055|Reactome: R-HSA-6791462|Reactome: R-HSA-71336 TK78_RS27935 dc920d8b36ce988a8cb6a221e91ac81e 372 Hamap MF_00493 Transaldolase [tal]. 1 370 163.315 T 09-03-2017 IPR004732 Transaldolase type 2 GO:0004801|GO:0005737|GO:0006098 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723 TK78_RS27935 dc920d8b36ce988a8cb6a221e91ac81e 372 PIRSF PIRSF036915 1 372 5.6E-177 T 09-03-2017 IPR004732 Transaldolase type 2 GO:0004801|GO:0005737|GO:0006098 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723 TK78_RS27935 dc920d8b36ce988a8cb6a221e91ac81e 372 SUPERFAMILY SSF51569 2 359 3.42E-77 T 09-03-2017 TK78_RS27935 dc920d8b36ce988a8cb6a221e91ac81e 372 ProSitePatterns PS01054 Transaldolase signature 1. 41 49 - T 09-03-2017 IPR018225 Transaldolase, active site GO:0005975 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723|Reactome: R-HSA-163754|Reactome: R-HSA-6791055|Reactome: R-HSA-6791462|Reactome: R-HSA-71336 TK78_RS27935 dc920d8b36ce988a8cb6a221e91ac81e 372 TIGRFAM TIGR00876 tal_mycobact: transaldolase 12 359 1.0E-133 T 09-03-2017 IPR004732 Transaldolase type 2 GO:0004801|GO:0005737|GO:0006098 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723 TK78_RS07690 6c3123d1d9b20b27b17f3b824480e6f8 1325 TIGRFAM TIGR03924 T7SS_EccC_a: type VII secretion protein EccCa 24 689 7.5E-261 T 09-03-2017 IPR023836 EccCa-like, Actinobacteria TK78_RS07690 6c3123d1d9b20b27b17f3b824480e6f8 1325 TIGRFAM TIGR03925 T7SS_EccC_b: type VII secretion protein EccCb 746 1318 9.2E-236 T 09-03-2017 IPR023837 EccCb-like, Actinobacteria TK78_RS07690 6c3123d1d9b20b27b17f3b824480e6f8 1325 Gene3D G3DSA:3.40.50.300 1095 1253 4.9E-6 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07690 6c3123d1d9b20b27b17f3b824480e6f8 1325 Gene3D G3DSA:3.40.50.300 438 651 4.8E-19 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07690 6c3123d1d9b20b27b17f3b824480e6f8 1325 Gene3D G3DSA:3.40.50.300 826 1009 2.0E-8 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07690 6c3123d1d9b20b27b17f3b824480e6f8 1325 SMART SM00382 1115 1278 4.3 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS07690 6c3123d1d9b20b27b17f3b824480e6f8 1325 SMART SM00382 466 645 1.1 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS07690 6c3123d1d9b20b27b17f3b824480e6f8 1325 SMART SM00382 827 1001 0.52 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS07690 6c3123d1d9b20b27b17f3b824480e6f8 1325 Pfam PF01580 FtsK/SpoIIIE family 433 557 3.3E-24 T 09-03-2017 IPR002543 FtsK domain GO:0000166|GO:0003677|GO:0005524 TK78_RS07690 6c3123d1d9b20b27b17f3b824480e6f8 1325 Pfam PF01580 FtsK/SpoIIIE family 807 1042 2.5E-45 T 09-03-2017 IPR002543 FtsK domain GO:0000166|GO:0003677|GO:0005524 TK78_RS07690 6c3123d1d9b20b27b17f3b824480e6f8 1325 SUPERFAMILY SSF52540 429 644 2.24E-29 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07690 6c3123d1d9b20b27b17f3b824480e6f8 1325 SUPERFAMILY SSF52540 1076 1253 9.03E-11 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07690 6c3123d1d9b20b27b17f3b824480e6f8 1325 SUPERFAMILY SSF52540 764 1023 5.23E-19 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS21330 d226ab450ecd6a1c3638b7bb2a8fd4c7 328 PRINTS PR00075 Fatty acid desaturase family 1 signature 63 85 6.7E-16 T 09-03-2017 IPR015876 Fatty acid desaturase, type 1, core GO:0016717|GO:0055114 Reactome: R-HSA-75105 TK78_RS21330 d226ab450ecd6a1c3638b7bb2a8fd4c7 328 PRINTS PR00075 Fatty acid desaturase family 1 signature 266 280 6.7E-16 T 09-03-2017 IPR015876 Fatty acid desaturase, type 1, core GO:0016717|GO:0055114 Reactome: R-HSA-75105 TK78_RS21330 d226ab450ecd6a1c3638b7bb2a8fd4c7 328 PRINTS PR00075 Fatty acid desaturase family 1 signature 223 244 6.7E-16 T 09-03-2017 IPR015876 Fatty acid desaturase, type 1, core GO:0016717|GO:0055114 Reactome: R-HSA-75105 TK78_RS21330 d226ab450ecd6a1c3638b7bb2a8fd4c7 328 PRINTS PR00075 Fatty acid desaturase family 1 signature 86 106 6.7E-16 T 09-03-2017 IPR015876 Fatty acid desaturase, type 1, core GO:0016717|GO:0055114 Reactome: R-HSA-75105 TK78_RS21330 d226ab450ecd6a1c3638b7bb2a8fd4c7 328 Pfam PF00487 Fatty acid desaturase 64 279 5.4E-21 T 09-03-2017 IPR005804 Fatty acid desaturase domain GO:0006629 TK78_RS11360 d732043010b1fef87ed15f230c6fdb9d 407 Pfam PF02601 Exonuclease VII, large subunit 333 399 4.0E-7 T 09-03-2017 IPR020579 Exonuclease VII, large subunit, C-terminal GO:0008855 TK78_RS11360 d732043010b1fef87ed15f230c6fdb9d 407 Pfam PF02601 Exonuclease VII, large subunit 129 344 2.4E-60 T 09-03-2017 IPR020579 Exonuclease VII, large subunit, C-terminal GO:0008855 TK78_RS11360 d732043010b1fef87ed15f230c6fdb9d 407 Hamap MF_00378 Exodeoxyribonuclease 7 large subunit [xseA]. 5 402 25.349 T 09-03-2017 IPR003753 Exonuclease VII, large subunit GO:0006308|GO:0008855|GO:0009318 TK78_RS11360 d732043010b1fef87ed15f230c6fdb9d 407 Pfam PF13742 OB-fold nucleic acid binding domain 12 106 4.5E-18 T 09-03-2017 IPR025824 OB-fold nucleic acid binding domain GO:0003676 TK78_RS11360 d732043010b1fef87ed15f230c6fdb9d 407 TIGRFAM TIGR00237 xseA: exodeoxyribonuclease VII, large subunit 13 401 1.7E-117 T 09-03-2017 IPR003753 Exonuclease VII, large subunit GO:0006308|GO:0008855|GO:0009318 TK78_RS27095 9ff5b6d9d4ad1ee7baa52d604ba6b457 455 ProSitePatterns PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. 382 406 - T 09-03-2017 IPR018365 Cell cycle, FtsW / RodA / SpoVE, conserved site GO:0007049|GO:0016021 TK78_RS27095 9ff5b6d9d4ad1ee7baa52d604ba6b457 455 TIGRFAM TIGR02614 ftsW: cell division protein FtsW 66 423 2.1E-112 T 09-03-2017 IPR013437 Cell division protein FtsW GO:0009252|GO:0016021|GO:0051301 TK78_RS27095 9ff5b6d9d4ad1ee7baa52d604ba6b457 455 Pfam PF01098 Cell cycle protein 69 422 1.5E-93 T 09-03-2017 IPR001182 Cell cycle protein FtsW/RodA GO:0016021|GO:0051301 TK78_RS13815 513f78b1bbb63d0333fe7a0ff1ac8b1b 802 Pfam PF00069 Protein kinase domain 15 261 5.3E-38 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS13815 513f78b1bbb63d0333fe7a0ff1ac8b1b 802 Pfam PF13570 PQQ-like domain 430 461 0.0023 T 09-03-2017 IPR025666 Pyrrolo-quinoline quinone-like domain TK78_RS13815 513f78b1bbb63d0333fe7a0ff1ac8b1b 802 Gene3D G3DSA:2.140.10.10 399 454 1.4E-60 T 09-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain TK78_RS13815 513f78b1bbb63d0333fe7a0ff1ac8b1b 802 Gene3D G3DSA:2.140.10.10 488 790 1.4E-60 T 09-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain TK78_RS13815 513f78b1bbb63d0333fe7a0ff1ac8b1b 802 Gene3D G3DSA:1.10.510.10 98 262 1.9E-40 T 09-03-2017 TK78_RS13815 513f78b1bbb63d0333fe7a0ff1ac8b1b 802 SUPERFAMILY SSF56112 11 341 7.69E-63 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS13815 513f78b1bbb63d0333fe7a0ff1ac8b1b 802 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 21 43 - T 09-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 TK78_RS13815 513f78b1bbb63d0333fe7a0ff1ac8b1b 802 Pfam PF13360 PQQ-like domain 645 793 5.0E-20 T 09-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat TK78_RS13815 513f78b1bbb63d0333fe7a0ff1ac8b1b 802 Pfam PF13360 PQQ-like domain 478 634 6.4E-20 T 09-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat TK78_RS13815 513f78b1bbb63d0333fe7a0ff1ac8b1b 802 SMART SM00564 476 507 63.0 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS13815 513f78b1bbb63d0333fe7a0ff1ac8b1b 802 SMART SM00564 559 589 5.0E-4 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS13815 513f78b1bbb63d0333fe7a0ff1ac8b1b 802 SMART SM00564 649 680 4.5E-6 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS13815 513f78b1bbb63d0333fe7a0ff1ac8b1b 802 SMART SM00564 689 720 53.0 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS13815 513f78b1bbb63d0333fe7a0ff1ac8b1b 802 SMART SM00564 605 634 210.0 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS13815 513f78b1bbb63d0333fe7a0ff1ac8b1b 802 SMART SM00564 769 800 0.88 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS13815 513f78b1bbb63d0333fe7a0ff1ac8b1b 802 SMART SM00564 728 760 0.4 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS13815 513f78b1bbb63d0333fe7a0ff1ac8b1b 802 SMART SM00564 442 471 24.0 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS13815 513f78b1bbb63d0333fe7a0ff1ac8b1b 802 SMART SM00564 514 546 28.0 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS13815 513f78b1bbb63d0333fe7a0ff1ac8b1b 802 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 133 145 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS13815 513f78b1bbb63d0333fe7a0ff1ac8b1b 802 SMART SM00220 15 270 2.0E-40 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS13815 513f78b1bbb63d0333fe7a0ff1ac8b1b 802 SUPERFAMILY SSF50998 421 457 9.42E-32 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS13815 513f78b1bbb63d0333fe7a0ff1ac8b1b 802 SUPERFAMILY SSF50998 491 683 9.42E-32 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS13815 513f78b1bbb63d0333fe7a0ff1ac8b1b 802 Gene3D G3DSA:3.30.200.20 6 81 1.2E-12 T 09-03-2017 TK78_RS13815 513f78b1bbb63d0333fe7a0ff1ac8b1b 802 SUPERFAMILY SSF50998 648 795 5.18E-27 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS00485 320f95f0c3a5210ab19f2c8e500d4f2e 333 SUPERFAMILY SSF53822 54 330 1.53E-57 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS00485 320f95f0c3a5210ab19f2c8e500d4f2e 333 SMART SM00354 1 65 2.4E-18 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS00485 320f95f0c3a5210ab19f2c8e500d4f2e 333 Pfam PF00356 Bacterial regulatory proteins, lacI family 1 42 2.1E-14 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS00485 320f95f0c3a5210ab19f2c8e500d4f2e 333 Gene3D G3DSA:1.10.260.40 1 47 3.1E-19 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS00485 320f95f0c3a5210ab19f2c8e500d4f2e 333 Gene3D G3DSA:3.40.50.2300 48 174 1.0E-26 T 09-03-2017 TK78_RS00485 320f95f0c3a5210ab19f2c8e500d4f2e 333 Gene3D G3DSA:3.40.50.2300 175 328 2.1E-49 T 09-03-2017 TK78_RS00485 320f95f0c3a5210ab19f2c8e500d4f2e 333 Pfam PF13377 Periplasmic binding protein-like domain 168 326 2.5E-35 T 09-03-2017 TK78_RS00485 320f95f0c3a5210ab19f2c8e500d4f2e 333 SUPERFAMILY SSF47413 1 53 3.88E-13 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS03415 4cb3ca81fbeae1cb843d7e38ccb1989d 746 Pfam PF06439 Domain of Unknown Function (DUF1080) 537 744 4.7E-30 T 09-03-2017 IPR010496 Domain of unknown function DUF1080 TK78_RS03415 4cb3ca81fbeae1cb843d7e38ccb1989d 746 Gene3D G3DSA:2.60.40.420 44 155 1.2E-13 T 09-03-2017 IPR008972 Cupredoxin TK78_RS03415 4cb3ca81fbeae1cb843d7e38ccb1989d 746 ProSitePatterns PS00196 Type-1 copper (blue) proteins signature. 134 148 - T 09-03-2017 IPR028871 Blue (type 1) copper protein, binding site TK78_RS03415 4cb3ca81fbeae1cb843d7e38ccb1989d 746 Pfam PF00127 Copper binding proteins, plastocyanin/azurin family 83 154 2.7E-5 T 09-03-2017 IPR000923 Blue (type 1) copper domain GO:0005507|GO:0009055 TK78_RS03415 4cb3ca81fbeae1cb843d7e38ccb1989d 746 SUPERFAMILY SSF49503 50 155 2.74E-12 T 09-03-2017 IPR008972 Cupredoxin TK78_RS23290 1d2cd6e8a7007f182f255348b1cf0ba3 218 Pfam PF07883 Cupin domain 36 104 2.4E-12 T 09-03-2017 IPR013096 Cupin 2, conserved barrel TK78_RS23290 1d2cd6e8a7007f182f255348b1cf0ba3 218 Gene3D G3DSA:2.60.120.10 10 112 4.9E-17 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS23290 1d2cd6e8a7007f182f255348b1cf0ba3 218 SUPERFAMILY SSF51182 18 113 2.97E-16 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS18310 fe9160b44233621bbc9103485a4b7562 1310 Pfam PF00271 Helicase conserved C-terminal domain 284 401 1.1E-9 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS18310 fe9160b44233621bbc9103485a4b7562 1310 TIGRFAM TIGR01967 DEAH_box_HrpA: RNA helicase HrpA 9 1306 0.0 T 09-03-2017 IPR010222 RNA helicase HrpA GO:0004004 TK78_RS18310 fe9160b44233621bbc9103485a4b7562 1310 SUPERFAMILY SSF52540 70 599 6.8E-113 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18310 fe9160b44233621bbc9103485a4b7562 1310 SMART SM00382 88 382 1.2E-4 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS18310 fe9160b44233621bbc9103485a4b7562 1310 Gene3D G3DSA:3.40.50.300 72 230 5.5E-47 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18310 fe9160b44233621bbc9103485a4b7562 1310 SMART SM00847 462 557 3.1E-39 T 09-03-2017 IPR007502 Helicase-associated domain GO:0004386 TK78_RS18310 fe9160b44233621bbc9103485a4b7562 1310 SMART SM00490 302 402 3.3E-14 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS18310 fe9160b44233621bbc9103485a4b7562 1310 Pfam PF04408 Helicase associated domain (HA2) 464 555 8.9E-19 T 09-03-2017 IPR007502 Helicase-associated domain GO:0004386 TK78_RS18310 fe9160b44233621bbc9103485a4b7562 1310 SMART SM00487 68 256 1.6E-26 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS18310 fe9160b44233621bbc9103485a4b7562 1310 Pfam PF07717 Oligonucleotide/oligosaccharide-binding (OB)-fold 619 700 3.7E-15 T 09-03-2017 IPR011709 Domain of unknown function DUF1605 TK78_RS18310 fe9160b44233621bbc9103485a4b7562 1310 Pfam PF11898 Domain of unknown function (DUF3418) 715 1306 9.4E-230 T 09-03-2017 IPR024590 RNA helicase HrpA, C-terminal TK78_RS18310 fe9160b44233621bbc9103485a4b7562 1310 Gene3D G3DSA:3.40.50.300 270 415 3.1E-12 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS04000 75d57e3896139efa570b4c3a464af49b 155 Gene3D G3DSA:2.80.10.50 13 153 1.7E-31 T 09-03-2017 TK78_RS04000 75d57e3896139efa570b4c3a464af49b 155 SUPERFAMILY SSF50370 8 153 1.44E-39 T 09-03-2017 IPR000772 Ricin B, lectin domain TK78_RS04000 75d57e3896139efa570b4c3a464af49b 155 Pfam PF14200 Ricin-type beta-trefoil lectin domain-like 10 90 6.6E-19 T 09-03-2017 IPR000772 Ricin B, lectin domain TK78_RS04000 75d57e3896139efa570b4c3a464af49b 155 SMART SM00458 12 152 1.7E-8 T 09-03-2017 IPR000772 Ricin B, lectin domain TK78_RS01700 52a7572c34c549273b42d2ab5fcf8077 518 Gene3D G3DSA:3.40.50.1820 3 153 3.1E-49 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS01700 52a7572c34c549273b42d2ab5fcf8077 518 Gene3D G3DSA:3.40.50.1820 213 320 3.1E-49 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS01700 52a7572c34c549273b42d2ab5fcf8077 518 SUPERFAMILY SSF53474 3 274 3.17E-30 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS01700 52a7572c34c549273b42d2ab5fcf8077 518 SUPERFAMILY SSF49785 339 504 5.95E-24 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS01700 52a7572c34c549273b42d2ab5fcf8077 518 Gene3D G3DSA:2.60.120.260 349 508 2.6E-28 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS01700 52a7572c34c549273b42d2ab5fcf8077 518 SMART SM00939 291 500 7.8E-8 T 09-03-2017 IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal GO:0008239 TK78_RS01700 52a7572c34c549273b42d2ab5fcf8077 518 Pfam PF08530 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain 371 485 9.6E-17 T 09-03-2017 IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal GO:0008239 TK78_RS01700 52a7572c34c549273b42d2ab5fcf8077 518 TIGRFAM TIGR00976 /NonD: hydrolase CocE/NonD family protein 8 309 1.0E-37 T 09-03-2017 IPR005674 CocE/Serine esterase GO:0016787 TK78_RS01700 52a7572c34c549273b42d2ab5fcf8077 518 Pfam PF02129 X-Pro dipeptidyl-peptidase (S15 family) 12 270 1.3E-33 T 09-03-2017 IPR000383 Xaa-Pro dipeptidyl-peptidase-like domain GO:0016787 TK78_RS05230 d69ea054b538af06f169d8fccb42eb83 517 SMART SM00644 223 351 8.6E-39 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS05230 d69ea054b538af06f169d8fccb42eb83 517 Pfam PF01510 N-acetylmuramoyl-L-alanine amidase 232 352 1.1E-22 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS05230 d69ea054b538af06f169d8fccb42eb83 517 Pfam PF01464 Transglycosylase SLT domain 47 154 1.2E-4 T 09-03-2017 IPR008258 Transglycosylase SLT domain 1 TK78_RS05230 d69ea054b538af06f169d8fccb42eb83 517 Gene3D G3DSA:3.40.80.10 212 364 2.5E-42 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS05230 d69ea054b538af06f169d8fccb42eb83 517 SUPERFAMILY SSF47090 448 513 3.14E-17 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS05230 d69ea054b538af06f169d8fccb42eb83 517 SUPERFAMILY SSF55846 215 363 1.7E-40 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS05230 d69ea054b538af06f169d8fccb42eb83 517 Gene3D G3DSA:1.10.101.10 449 514 3.9E-21 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS05230 d69ea054b538af06f169d8fccb42eb83 517 Gene3D G3DSA:1.10.101.10 381 444 2.1E-22 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS05230 d69ea054b538af06f169d8fccb42eb83 517 Gene3D G3DSA:1.10.530.10 41 159 2.1E-10 T 09-03-2017 TK78_RS05230 d69ea054b538af06f169d8fccb42eb83 517 SUPERFAMILY SSF47090 376 444 9.42E-20 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS05230 d69ea054b538af06f169d8fccb42eb83 517 Pfam PF01471 Putative peptidoglycan binding domain 387 443 4.9E-16 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS05230 d69ea054b538af06f169d8fccb42eb83 517 Pfam PF01471 Putative peptidoglycan binding domain 457 513 8.6E-13 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS05230 d69ea054b538af06f169d8fccb42eb83 517 SUPERFAMILY SSF53955 45 161 3.47E-10 T 09-03-2017 IPR023346 Lysozyme-like domain TK78_RS00740 20521bb810ac295559854eb3fea5842c 430 SUPERFAMILY SSF51445 11 413 1.61E-101 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS00740 20521bb810ac295559854eb3fea5842c 430 PRINTS PR00131 Glycosyl hydrolase family 1 signature 338 349 4.4E-12 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS00740 20521bb810ac295559854eb3fea5842c 430 PRINTS PR00131 Glycosyl hydrolase family 1 signature 269 283 4.4E-12 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS00740 20521bb810ac295559854eb3fea5842c 430 PRINTS PR00131 Glycosyl hydrolase family 1 signature 326 334 4.4E-12 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS00740 20521bb810ac295559854eb3fea5842c 430 PRINTS PR00131 Glycosyl hydrolase family 1 signature 359 376 4.4E-12 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS00740 20521bb810ac295559854eb3fea5842c 430 PRINTS PR00131 Glycosyl hydrolase family 1 signature 382 394 4.4E-12 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS00740 20521bb810ac295559854eb3fea5842c 430 Pfam PF00232 Glycosyl hydrolase family 1 292 409 1.1E-19 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS00740 20521bb810ac295559854eb3fea5842c 430 Pfam PF00232 Glycosyl hydrolase family 1 11 259 1.6E-36 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS00740 20521bb810ac295559854eb3fea5842c 430 Gene3D G3DSA:3.20.20.80 10 415 1.2E-92 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS08455 8b6e2005b95b9afa536df600d5280911 137 Pfam PF03259 Roadblock/LC7 domain 9 99 3.3E-25 T 09-03-2017 IPR004942 Roadblock/LAMTOR2 domain TK78_RS08455 8b6e2005b95b9afa536df600d5280911 137 SUPERFAMILY SSF103196 2 125 2.35E-32 T 09-03-2017 TK78_RS08455 8b6e2005b95b9afa536df600d5280911 137 SMART SM00960 9 99 2.9E-33 T 09-03-2017 IPR004942 Roadblock/LAMTOR2 domain TK78_RS08455 8b6e2005b95b9afa536df600d5280911 137 Gene3D G3DSA:3.30.450.30 3 123 8.4E-26 T 09-03-2017 TK78_RS08110 03f89464de943072f3220f5b092b8fdc 540 Pfam PF13335 Magnesium chelatase, subunit ChlI C-terminal 430 526 6.9E-21 T 09-03-2017 IPR025158 Mg chelatase-related protein, C-terminal domain TK78_RS08110 03f89464de943072f3220f5b092b8fdc 540 SMART SM00382 235 419 7.1E-7 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS08110 03f89464de943072f3220f5b092b8fdc 540 Pfam PF01078 Magnesium chelatase, subunit ChlI 215 421 1.6E-84 T 09-03-2017 IPR000523 Magnesium chelatase ChlI domain TK78_RS08110 03f89464de943072f3220f5b092b8fdc 540 SUPERFAMILY SSF54211 2 170 2.31E-36 T 09-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold TK78_RS08110 03f89464de943072f3220f5b092b8fdc 540 SUPERFAMILY SSF52540 489 526 2.18E-40 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08110 03f89464de943072f3220f5b092b8fdc 540 SUPERFAMILY SSF52540 215 447 2.18E-40 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08110 03f89464de943072f3220f5b092b8fdc 540 Gene3D G3DSA:3.40.50.300 215 415 1.2E-46 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08110 03f89464de943072f3220f5b092b8fdc 540 Gene3D G3DSA:3.30.230.10 7 168 1.3E-37 T 09-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TK78_RS08110 03f89464de943072f3220f5b092b8fdc 540 Pfam PF13541 Subunit ChlI of Mg-chelatase 21 142 1.5E-38 T 09-03-2017 TK78_RS04210 a59209899885601ef8ea4366a73bb1fc 271 Gene3D G3DSA:1.10.10.60 31 75 7.1E-19 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS04210 a59209899885601ef8ea4366a73bb1fc 271 ProSitePatterns PS01081 TetR-type HTH domain signature. 48 79 - T 09-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site TK78_RS04210 a59209899885601ef8ea4366a73bb1fc 271 Pfam PF00440 Bacterial regulatory proteins, tetR family 38 77 1.2E-16 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS04210 a59209899885601ef8ea4366a73bb1fc 271 Gene3D G3DSA:1.10.357.10 76 216 6.5E-26 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS04210 a59209899885601ef8ea4366a73bb1fc 271 SUPERFAMILY SSF46689 26 82 8.51E-16 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS04210 a59209899885601ef8ea4366a73bb1fc 271 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 36 49 3.2E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS04210 a59209899885601ef8ea4366a73bb1fc 271 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 57 80 3.2E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS29445 80c8d3f169a3eeba24a0c61c45276c29 424 SUPERFAMILY SSF51905 7 308 5.96E-48 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS29445 80c8d3f169a3eeba24a0c61c45276c29 424 SUPERFAMILY SSF51905 387 420 5.96E-48 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS29445 80c8d3f169a3eeba24a0c61c45276c29 424 Gene3D G3DSA:3.50.50.60 209 291 8.8E-33 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS29445 80c8d3f169a3eeba24a0c61c45276c29 424 Gene3D G3DSA:3.50.50.60 161 171 8.8E-33 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS29445 80c8d3f169a3eeba24a0c61c45276c29 424 Gene3D G3DSA:3.50.50.60 7 99 8.8E-33 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS29445 80c8d3f169a3eeba24a0c61c45276c29 424 Pfam PF01593 Flavin containing amine oxidoreductase 15 280 2.9E-27 T 09-03-2017 IPR002937 Amine oxidase GO:0016491|GO:0055114 TK78_RS31400 e8d05043a8362a600cc89d440d991905 210 Gene3D G3DSA:3.30.230.30 5 131 3.1E-44 T 09-03-2017 IPR001498 Impact, N-terminal TK78_RS31400 e8d05043a8362a600cc89d440d991905 210 Pfam PF09186 Domain of unknown function (DUF1949) 140 194 3.8E-13 T 09-03-2017 IPR015269 Uncharacterised domain UPF0029, Impact, C-terminal TK78_RS31400 e8d05043a8362a600cc89d440d991905 210 TIGRFAM TIGR00257 IMPACT_YIGZ: uncharacterized protein, YigZ family 1 200 5.4E-57 T 09-03-2017 IPR015796 Impact family, bacterial/archaeal TK78_RS31400 e8d05043a8362a600cc89d440d991905 210 Gene3D G3DSA:3.30.70.240 139 208 2.0E-12 T 09-03-2017 IPR000640 Translation elongation factor EFG, V domain TK78_RS31400 e8d05043a8362a600cc89d440d991905 210 SUPERFAMILY SSF54211 2 130 6.07E-40 T 09-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold TK78_RS31400 e8d05043a8362a600cc89d440d991905 210 Pfam PF01205 Uncharacterized protein family UPF0029 20 124 7.5E-29 T 09-03-2017 IPR001498 Impact, N-terminal TK78_RS31400 e8d05043a8362a600cc89d440d991905 210 SUPERFAMILY SSF54980 138 199 1.58E-15 T 09-03-2017 IPR009022 Elongation factor G, III-V domain TK78_RS06860 c41d10f3dec3f6eae3344a75971d9c3b 225 PRINTS PR00335 TrkA potassium uptake protein signature 2 16 7.3E-7 T 09-03-2017 IPR006036 Potassium uptake protein TrkA GO:0005886|GO:0006813|GO:0015079 TK78_RS06860 c41d10f3dec3f6eae3344a75971d9c3b 225 PRINTS PR00335 TrkA potassium uptake protein signature 59 69 7.3E-7 T 09-03-2017 IPR006036 Potassium uptake protein TrkA GO:0005886|GO:0006813|GO:0015079 TK78_RS06860 c41d10f3dec3f6eae3344a75971d9c3b 225 PRINTS PR00335 TrkA potassium uptake protein signature 72 86 7.3E-7 T 09-03-2017 IPR006036 Potassium uptake protein TrkA GO:0005886|GO:0006813|GO:0015079 TK78_RS06860 c41d10f3dec3f6eae3344a75971d9c3b 225 PRINTS PR00335 TrkA potassium uptake protein signature 19 33 7.3E-7 T 09-03-2017 IPR006036 Potassium uptake protein TrkA GO:0005886|GO:0006813|GO:0015079 TK78_RS06860 c41d10f3dec3f6eae3344a75971d9c3b 225 SUPERFAMILY SSF51735 1 145 3.01E-27 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS06860 c41d10f3dec3f6eae3344a75971d9c3b 225 Pfam PF02080 TrkA-C domain 149 216 6.1E-11 T 09-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 TK78_RS06860 c41d10f3dec3f6eae3344a75971d9c3b 225 SUPERFAMILY SSF116726 133 216 4.05E-13 T 09-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 TK78_RS06860 c41d10f3dec3f6eae3344a75971d9c3b 225 Gene3D G3DSA:3.30.70.1450 147 217 1.6E-10 T 09-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 TK78_RS06860 c41d10f3dec3f6eae3344a75971d9c3b 225 Gene3D G3DSA:3.40.50.720 1 132 3.7E-30 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS06860 c41d10f3dec3f6eae3344a75971d9c3b 225 Pfam PF02254 TrkA-N domain 5 118 3.8E-24 T 09-03-2017 IPR003148 Regulator of K+ conductance, N-terminal GO:0006813 TK78_RS27500 89bf25c889465f9942a4e0d469823df3 420 Gene3D G3DSA:3.10.180.10 10 127 7.7E-24 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS27500 89bf25c889465f9942a4e0d469823df3 420 SUPERFAMILY SSF54593 7 209 1.2E-21 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS27500 89bf25c889465f9942a4e0d469823df3 420 SUPERFAMILY SSF55729 237 393 8.42E-37 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS27500 89bf25c889465f9942a4e0d469823df3 420 Pfam PF13302 Acetyltransferase (GNAT) domain 243 385 3.2E-30 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS27500 89bf25c889465f9942a4e0d469823df3 420 Gene3D G3DSA:3.40.630.30 228 417 6.5E-48 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS24000 db7c946479c20df3b42f41d8959693e3 194 Gene3D G3DSA:3.40.630.30 4 163 5.4E-17 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS24000 db7c946479c20df3b42f41d8959693e3 194 Pfam PF13508 Acetyltransferase (GNAT) domain 104 160 5.4E-7 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS24000 db7c946479c20df3b42f41d8959693e3 194 SUPERFAMILY SSF55729 17 163 4.33E-16 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS23680 4acac9e181369e1a9dea7f3dcc5341a6 112 Pfam PF05973 Phage derived protein Gp49-like (DUF891) 10 86 4.0E-9 T 09-03-2017 IPR009241 Toxin HigB-like TK78_RS19890 8c0f44efa4e4e1e64dc5340e1be0f2df 616 TIGRFAM TIGR00110 ilvD: dihydroxy-acid dehydratase 18 611 6.7E-238 T 09-03-2017 IPR004404 Dihydroxy-acid dehydratase GO:0004160|GO:0009082 KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111 TK78_RS19890 8c0f44efa4e4e1e64dc5340e1be0f2df 616 Pfam PF00920 Dehydratase family 34 608 6.9E-215 T 09-03-2017 IPR000581 Dihydroxy-acid/6-phosphogluconate dehydratase GO:0003824|GO:0008152 KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111 TK78_RS19890 8c0f44efa4e4e1e64dc5340e1be0f2df 616 SUPERFAMILY SSF52016 426 612 3.37E-61 T 09-03-2017 IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel TK78_RS19890 8c0f44efa4e4e1e64dc5340e1be0f2df 616 Hamap MF_00012 Dihydroxy-acid dehydratase [ilvD]. 4 611 44.888 T 09-03-2017 IPR004404 Dihydroxy-acid dehydratase GO:0004160|GO:0009082 KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111 TK78_RS19890 8c0f44efa4e4e1e64dc5340e1be0f2df 616 ProSitePatterns PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2. 514 525 - T 09-03-2017 IPR020558 Dihydroxy-acid/6-phosphogluconate dehydratase, conserved site GO:0003824|GO:0008152 KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111 TK78_RS19890 8c0f44efa4e4e1e64dc5340e1be0f2df 616 SUPERFAMILY SSF143975 4 425 2.88E-131 T 09-03-2017 TK78_RS19890 8c0f44efa4e4e1e64dc5340e1be0f2df 616 ProSitePatterns PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 122 132 - T 09-03-2017 IPR020558 Dihydroxy-acid/6-phosphogluconate dehydratase, conserved site GO:0003824|GO:0008152 KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111 TK78_RS29810 a5b599654e490c1f35b8a88f5cc6d92c 309 Pfam PF00696 Amino acid kinase family 29 270 1.1E-48 T 09-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase TK78_RS29810 a5b599654e490c1f35b8a88f5cc6d92c 309 Gene3D G3DSA:3.40.1160.10 27 293 2.3E-98 T 09-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase TK78_RS29810 a5b599654e490c1f35b8a88f5cc6d92c 309 SUPERFAMILY SSF53633 8 295 1.31E-87 T 09-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase TK78_RS29810 a5b599654e490c1f35b8a88f5cc6d92c 309 PIRSF PIRSF000728 14 294 1.1E-98 T 09-03-2017 IPR004662 Acetylglutamate kinase GO:0003991|GO:0005737|GO:0006526 KEGG: 00220+2.7.2.8|MetaCyc: PWY-5154|MetaCyc: PWY-7400 TK78_RS29810 a5b599654e490c1f35b8a88f5cc6d92c 309 Hamap MF_00082_B Acetylglutamate kinase [argB]. 27 294 34.227 T 09-03-2017 IPR004662 Acetylglutamate kinase GO:0003991|GO:0005737|GO:0006526 KEGG: 00220+2.7.2.8|MetaCyc: PWY-5154|MetaCyc: PWY-7400 TK78_RS29810 a5b599654e490c1f35b8a88f5cc6d92c 309 TIGRFAM TIGR00761 argB: acetylglutamate kinase 30 268 8.7E-74 T 09-03-2017 IPR004662 Acetylglutamate kinase GO:0003991|GO:0005737|GO:0006526 KEGG: 00220+2.7.2.8|MetaCyc: PWY-5154|MetaCyc: PWY-7400 TK78_RS29810 a5b599654e490c1f35b8a88f5cc6d92c 309 PRINTS PR00474 Glutamate 5-kinase family signature 193 220 2.6E-10 T 09-03-2017 IPR001057 Glutamate/acetylglutamate kinase GO:0006561 Reactome: R-HSA-70614 TK78_RS29810 a5b599654e490c1f35b8a88f5cc6d92c 309 PRINTS PR00474 Glutamate 5-kinase family signature 60 74 2.6E-10 T 09-03-2017 IPR001057 Glutamate/acetylglutamate kinase GO:0006561 Reactome: R-HSA-70614 TK78_RS29810 a5b599654e490c1f35b8a88f5cc6d92c 309 PRINTS PR00474 Glutamate 5-kinase family signature 244 264 2.6E-10 T 09-03-2017 IPR001057 Glutamate/acetylglutamate kinase GO:0006561 Reactome: R-HSA-70614 TK78_RS29810 a5b599654e490c1f35b8a88f5cc6d92c 309 PRINTS PR00474 Glutamate 5-kinase family signature 160 181 2.6E-10 T 09-03-2017 IPR001057 Glutamate/acetylglutamate kinase GO:0006561 Reactome: R-HSA-70614 TK78_RS01480 c61d1f0e10d7c782af0b25a377740bc5 429 SUPERFAMILY SSF50998 82 424 3.01E-26 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS01480 c61d1f0e10d7c782af0b25a377740bc5 429 SMART SM00564 351 382 0.068 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS01480 c61d1f0e10d7c782af0b25a377740bc5 429 SMART SM00564 229 261 95.0 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS01480 c61d1f0e10d7c782af0b25a377740bc5 429 SMART SM00564 148 180 14.0 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS01480 c61d1f0e10d7c782af0b25a377740bc5 429 SMART SM00564 189 221 11.0 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS01480 c61d1f0e10d7c782af0b25a377740bc5 429 SMART SM00564 311 342 6.8 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS01480 c61d1f0e10d7c782af0b25a377740bc5 429 Pfam PF13360 PQQ-like domain 290 391 2.1E-14 T 09-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat TK78_RS01480 c61d1f0e10d7c782af0b25a377740bc5 429 Pfam PF13360 PQQ-like domain 124 257 3.8E-16 T 09-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat TK78_RS01480 c61d1f0e10d7c782af0b25a377740bc5 429 Gene3D G3DSA:2.140.10.10 69 427 1.1E-43 T 09-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain TK78_RS33105 d4081330503349897d75f2c87fdca3e7 205 SUPERFAMILY SSF89392 34 190 2.2E-9 T 09-03-2017 IPR029046 Lipoprotein localisation LolA/LolB/LppX TK78_RS15845 8659fbc6b9bd9ecfbf16149b53f6b478 78 Pfam PF04149 Domain of unknown function (DUF397) 6 25 9.2E-7 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS15845 8659fbc6b9bd9ecfbf16149b53f6b478 78 Pfam PF04149 Domain of unknown function (DUF397) 26 76 2.5E-20 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS11935 5ed875dc03507503ecd1543b1919b5a0 121 Gene3D G3DSA:3.30.70.900 1 97 7.9E-29 T 09-03-2017 TK78_RS11935 5ed875dc03507503ecd1543b1919b5a0 121 SUPERFAMILY SSF54909 1 97 7.78E-25 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS11935 5ed875dc03507503ecd1543b1919b5a0 121 Pfam PF07045 Domain of unknown function (DUF1330) 2 97 3.0E-25 T 09-03-2017 IPR010753 Domain of unknown function DUF1330 TK78_RS32280 43cc0962d89b5b1fdbbe79ca570b67e6 119 SUPERFAMILY SSF52499 17 118 8.63E-25 T 09-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 TK78_RS32280 43cc0962d89b5b1fdbbe79ca570b67e6 119 Gene3D G3DSA:3.40.50.850 18 118 2.9E-23 T 09-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 TK78_RS32280 43cc0962d89b5b1fdbbe79ca570b67e6 119 Pfam PF00857 Isochorismatase family 19 118 2.3E-21 T 09-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 TK78_RS05890 30ba4cbbb13174329e919fe3e3e1c7df 242 Pfam PF06778 Chlorite dismutase 44 231 7.9E-74 T 09-03-2017 IPR010644 Putative heme-dependent peroxidase/Chlorite dismutase TK78_RS05890 30ba4cbbb13174329e919fe3e3e1c7df 242 Gene3D G3DSA:3.30.70.1100 144 241 8.7E-41 T 09-03-2017 TK78_RS05890 30ba4cbbb13174329e919fe3e3e1c7df 242 SUPERFAMILY SSF54909 22 241 1.66E-75 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS05890 30ba4cbbb13174329e919fe3e3e1c7df 242 Gene3D G3DSA:3.30.70.1030 28 143 6.7E-27 T 09-03-2017 TK78_RS17400 de13f7537d90fad10aef9c3b88e4c8ab 880 Gene3D G3DSA:3.30.1360.40 260 356 3.0E-32 T 09-03-2017 IPR024946 Arginine repressor C-terminal-like domain TK78_RS17400 de13f7537d90fad10aef9c3b88e4c8ab 880 TIGRFAM TIGR01063 gyrA: DNA gyrase, A subunit 28 835 0.0 T 09-03-2017 TK78_RS17400 de13f7537d90fad10aef9c3b88e4c8ab 880 Hamap MF_01897 DNA gyrase subunit A [gyrA]. 18 837 23.021 T 09-03-2017 IPR005743 DNA gyrase, subunit A GO:0003677|GO:0003918|GO:0005524|GO:0005694|GO:0006265 TK78_RS17400 de13f7537d90fad10aef9c3b88e4c8ab 880 Gene3D G3DSA:3.90.199.10 357 421 1.2E-113 T 09-03-2017 IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta GO:0003677|GO:0003918|GO:0005524|GO:0006259|GO:0006265 Reactome: R-HSA-4615885 TK78_RS17400 de13f7537d90fad10aef9c3b88e4c8ab 880 Gene3D G3DSA:3.90.199.10 50 259 1.2E-113 T 09-03-2017 IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta GO:0003677|GO:0003918|GO:0005524|GO:0006259|GO:0006265 Reactome: R-HSA-4615885 TK78_RS17400 de13f7537d90fad10aef9c3b88e4c8ab 880 SUPERFAMILY SSF56719 50 510 5.62E-170 T 09-03-2017 IPR013760 DNA topoisomerase, type IIA-like domain GO:0003918|GO:0005524 Reactome: R-HSA-4615885 TK78_RS17400 de13f7537d90fad10aef9c3b88e4c8ab 880 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 527 572 4.1E-14 T 09-03-2017 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 TK78_RS17400 de13f7537d90fad10aef9c3b88e4c8ab 880 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 634 683 2.2E-6 T 09-03-2017 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 TK78_RS17400 de13f7537d90fad10aef9c3b88e4c8ab 880 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 686 734 4.0E-12 T 09-03-2017 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 TK78_RS17400 de13f7537d90fad10aef9c3b88e4c8ab 880 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 578 624 3.5E-9 T 09-03-2017 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 TK78_RS17400 de13f7537d90fad10aef9c3b88e4c8ab 880 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 740 785 2.0E-13 T 09-03-2017 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 TK78_RS17400 de13f7537d90fad10aef9c3b88e4c8ab 880 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 789 833 3.4E-11 T 09-03-2017 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 TK78_RS17400 de13f7537d90fad10aef9c3b88e4c8ab 880 SMART SM00434 31 488 1.9E-278 T 09-03-2017 IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS17400 de13f7537d90fad10aef9c3b88e4c8ab 880 SUPERFAMILY SSF101904 522 843 1.24E-98 T 09-03-2017 TK78_RS17400 de13f7537d90fad10aef9c3b88e4c8ab 880 Gene3D G3DSA:2.120.10.90 520 834 2.1E-118 T 09-03-2017 TK78_RS17400 de13f7537d90fad10aef9c3b88e4c8ab 880 Pfam PF00521 DNA gyrase/topoisomerase IV, subunit A 52 495 4.7E-150 T 09-03-2017 IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS29100 ed379bda5eb6d2ff15ff4da03361c1bb 340 SUPERFAMILY SSF56112 7 313 5.92E-62 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS29100 ed379bda5eb6d2ff15ff4da03361c1bb 340 Gene3D G3DSA:3.90.1200.10 126 314 8.3E-34 T 09-03-2017 TK78_RS29100 ed379bda5eb6d2ff15ff4da03361c1bb 340 Pfam PF01636 Phosphotransferase enzyme family 32 289 3.5E-51 T 09-03-2017 IPR002575 Aminoglycoside phosphotransferase TK78_RS05245 10313f0016cb3b4a74e926826a6ea78f 1220 ProSitePatterns PS00136 Serine proteases, subtilase family, aspartic acid active site. 211 222 - T 09-03-2017 IPR023827 Peptidase S8, subtilisin, Asp-active site TK78_RS05245 10313f0016cb3b4a74e926826a6ea78f 1220 Gene3D G3DSA:2.60.40.360 500 564 9.7E-5 T 09-03-2017 IPR008962 PapD-like TK78_RS05245 10313f0016cb3b4a74e926826a6ea78f 1220 SUPERFAMILY SSF52743 191 476 9.16E-82 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS05245 10313f0016cb3b4a74e926826a6ea78f 1220 SUPERFAMILY SSF52025 762 861 8.24E-10 T 09-03-2017 TK78_RS05245 10313f0016cb3b4a74e926826a6ea78f 1220 PIRSF PIRSF037852 1 1220 0.0 T 09-03-2017 IPR017296 Peptidase S8A, SAM-P45 TK78_RS05245 10313f0016cb3b4a74e926826a6ea78f 1220 ProSitePatterns PS00137 Serine proteases, subtilase family, histidine active site. 247 257 - T 09-03-2017 IPR022398 Peptidase S8, subtilisin, His-active site TK78_RS05245 10313f0016cb3b4a74e926826a6ea78f 1220 Pfam PF02225 PA domain 775 856 1.5E-7 T 09-03-2017 IPR003137 PA domain TK78_RS05245 10313f0016cb3b4a74e926826a6ea78f 1220 Gene3D G3DSA:3.50.30.30 769 868 2.8E-13 T 09-03-2017 TK78_RS05245 10313f0016cb3b4a74e926826a6ea78f 1220 Gene3D G3DSA:3.40.50.200 192 475 1.3E-86 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS05245 10313f0016cb3b4a74e926826a6ea78f 1220 Pfam PF00082 Subtilase family 206 467 6.3E-56 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS05245 10313f0016cb3b4a74e926826a6ea78f 1220 ProSitePatterns PS00138 Serine proteases, subtilase family, serine active site. 418 428 - T 09-03-2017 IPR023828 Peptidase S8, subtilisin, Ser-active site TK78_RS05245 10313f0016cb3b4a74e926826a6ea78f 1220 PRINTS PR00723 Subtilisin serine protease family (S8) signature 417 433 3.1E-21 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS05245 10313f0016cb3b4a74e926826a6ea78f 1220 PRINTS PR00723 Subtilisin serine protease family (S8) signature 206 225 3.1E-21 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS05245 10313f0016cb3b4a74e926826a6ea78f 1220 PRINTS PR00723 Subtilisin serine protease family (S8) signature 243 256 3.1E-21 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS16010 a554c1cdc3931d700bd2950ee27ba5fd 532 Gene3D G3DSA:1.20.1250.20 26 208 5.2E-8 T 09-03-2017 TK78_RS16010 a554c1cdc3931d700bd2950ee27ba5fd 532 Hamap MF_00198 Polyamine aminopropyltransferase [speE]. 202 524 20.535 T 09-03-2017 IPR001045 Spermidine/spermine synthases GO:0003824 KEGG: 00270+2.5.1.16|KEGG: 00330+2.5.1.16|KEGG: 00410+2.5.1.16|KEGG: 00480+2.5.1.16|Reactome: R-HSA-351202 TK78_RS16010 a554c1cdc3931d700bd2950ee27ba5fd 532 Gene3D G3DSA:3.40.50.150 285 489 5.1E-55 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS16010 a554c1cdc3931d700bd2950ee27ba5fd 532 SUPERFAMILY SSF53335 237 462 3.54E-50 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS16010 a554c1cdc3931d700bd2950ee27ba5fd 532 SUPERFAMILY SSF103473 24 208 1.83E-8 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS16010 a554c1cdc3931d700bd2950ee27ba5fd 532 Pfam PF01564 Spermine/spermidine synthase 247 435 1.4E-29 T 09-03-2017 TK78_RS16010 a554c1cdc3931d700bd2950ee27ba5fd 532 ProSitePatterns PS01330 Polyamine biosynthesis (PABS) domain signature. 306 319 - T 09-03-2017 IPR030373 Polyamine biosynthesis domain, conserved site KEGG: 00270+2.5.1.16|KEGG: 00330+2.5.1.16|KEGG: 00410+2.5.1.16|KEGG: 00480+2.5.1.16|Reactome: R-HSA-351202 TK78_RS29760 698adf73fa69cd3fdaa13047405c2112 431 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 65 383 1.4E-35 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS29760 698adf73fa69cd3fdaa13047405c2112 431 TIGRFAM TIGR03844 cysteate_syn: cysteate synthase 4 404 2.5E-124 T 09-03-2017 IPR022401 Cysteate synthase GO:0016765 MetaCyc: PWY-6643 TK78_RS29760 698adf73fa69cd3fdaa13047405c2112 431 SUPERFAMILY SSF53686 51 388 3.93E-37 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS29760 698adf73fa69cd3fdaa13047405c2112 431 Gene3D G3DSA:3.40.50.1100 144 400 3.3E-31 T 09-03-2017 TK78_RS02350 61059b7232357ff1216c57ccc1a54ad7 298 SUPERFAMILY SSF88659 224 294 8.78E-16 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS02350 61059b7232357ff1216c57ccc1a54ad7 298 Gene3D G3DSA:1.10.10.10 142 197 1.7E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS02350 61059b7232357ff1216c57ccc1a54ad7 298 SUPERFAMILY SSF88946 33 143 2.04E-31 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS02350 61059b7232357ff1216c57ccc1a54ad7 298 Gene3D G3DSA:1.10.601.10 55 141 2.7E-26 T 09-03-2017 TK78_RS02350 61059b7232357ff1216c57ccc1a54ad7 298 PRINTS PR00046 Major sigma-70 factor signature 247 259 1.6E-10 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS02350 61059b7232357ff1216c57ccc1a54ad7 298 PRINTS PR00046 Major sigma-70 factor signature 98 111 1.6E-10 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS02350 61059b7232357ff1216c57ccc1a54ad7 298 PRINTS PR00046 Major sigma-70 factor signature 264 279 1.6E-10 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS02350 61059b7232357ff1216c57ccc1a54ad7 298 Pfam PF04545 Sigma-70, region 4 243 292 1.8E-17 T 09-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS02350 61059b7232357ff1216c57ccc1a54ad7 298 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 69 293 3.4E-33 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS02350 61059b7232357ff1216c57ccc1a54ad7 298 Gene3D G3DSA:1.10.10.10 240 294 1.1E-10 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS02350 61059b7232357ff1216c57ccc1a54ad7 298 SUPERFAMILY SSF88659 147 214 3.18E-14 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS02350 61059b7232357ff1216c57ccc1a54ad7 298 Pfam PF04539 Sigma-70 region 3 153 217 1.0E-11 T 09-03-2017 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS02350 61059b7232357ff1216c57ccc1a54ad7 298 Pfam PF04542 Sigma-70 region 2 73 143 3.5E-15 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS02350 61059b7232357ff1216c57ccc1a54ad7 298 ProSitePatterns PS00715 Sigma-70 factors family signature 1. 98 111 - T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS02350 61059b7232357ff1216c57ccc1a54ad7 298 TIGRFAM TIGR02980 SigBFG: RNA polymerase sigma-70 factor, sigma-B/F/G subfamily 67 294 2.2E-89 T 09-03-2017 IPR014322 RNA polymerase sigma-B/F/G type GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS10990 c33726de62fd73ab3ee629338d97aa1e 309 Gene3D G3DSA:1.10.3720.10 89 305 6.7E-15 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS10990 c33726de62fd73ab3ee629338d97aa1e 309 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 114 308 2.1E-35 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS10990 c33726de62fd73ab3ee629338d97aa1e 309 SUPERFAMILY SSF161098 92 290 3.76E-16 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS26765 9a1e79ec382358f9028a0465b25c71dd 132 Pfam PF12270 Cytochrome c oxidase subunit IV 2 129 4.7E-53 T 09-03-2017 IPR021050 Cytochrome c oxidase subunit IV, actinobacteria GO:0004129|GO:0016021|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279 TK78_RS26765 9a1e79ec382358f9028a0465b25c71dd 132 PIRSF PIRSF017385 1 131 4.0E-49 T 09-03-2017 IPR021050 Cytochrome c oxidase subunit IV, actinobacteria GO:0004129|GO:0016021|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279 TK78_RS12040 fb1ece6a524c8e0a334efb98bf126947 546 Pfam PF00408 Phosphoglucomutase/phosphomannomutase, C-terminal domain 455 525 1.3E-11 T 09-03-2017 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12040 fb1ece6a524c8e0a334efb98bf126947 546 Pfam PF02880 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III 318 425 2.9E-16 T 09-03-2017 IPR005846 Alpha-D-phosphohexomutase, alpha/beta/alpha domain III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12040 fb1ece6a524c8e0a334efb98bf126947 546 Gene3D G3DSA:3.30.310.50 455 513 1.6E-20 T 09-03-2017 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12040 fb1ece6a524c8e0a334efb98bf126947 546 Gene3D G3DSA:3.40.120.10 300 432 1.6E-33 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12040 fb1ece6a524c8e0a334efb98bf126947 546 Pfam PF02879 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II 214 303 1.2E-22 T 09-03-2017 IPR005845 Alpha-D-phosphohexomutase, alpha/beta/alpha domain II GO:0005975 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12040 fb1ece6a524c8e0a334efb98bf126947 546 SUPERFAMILY SSF53738 35 182 4.71E-41 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12040 fb1ece6a524c8e0a334efb98bf126947 546 Gene3D G3DSA:3.40.120.10 222 299 8.9E-21 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12040 fb1ece6a524c8e0a334efb98bf126947 546 Gene3D G3DSA:3.40.120.10 18 181 1.8E-57 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12040 fb1ece6a524c8e0a334efb98bf126947 546 SUPERFAMILY SSF55957 432 515 1.05E-15 T 09-03-2017 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12040 fb1ece6a524c8e0a334efb98bf126947 546 Pfam PF02878 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I 45 180 1.2E-39 T 09-03-2017 IPR005844 Alpha-D-phosphohexomutase, alpha/beta/alpha domain I GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12040 fb1ece6a524c8e0a334efb98bf126947 546 ProSitePatterns PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 141 150 - T 09-03-2017 IPR016066 Alpha-D-phosphohexomutase, conserved site GO:0000287 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12040 fb1ece6a524c8e0a334efb98bf126947 546 SUPERFAMILY SSF53738 295 426 4.71E-27 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12040 fb1ece6a524c8e0a334efb98bf126947 546 SUPERFAMILY SSF53738 218 307 9.03E-21 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS32410 8c5c3cb0aab7ce652ebdb22164628564 464 Gene3D G3DSA:3.20.20.140 127 416 7.7E-89 T 09-03-2017 TK78_RS32410 8c5c3cb0aab7ce652ebdb22164628564 464 Gene3D G3DSA:2.30.40.10 71 126 1.7E-9 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS32410 8c5c3cb0aab7ce652ebdb22164628564 464 SUPERFAMILY SSF51338 417 463 2.26E-7 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS32410 8c5c3cb0aab7ce652ebdb22164628564 464 SUPERFAMILY SSF51338 83 118 2.26E-7 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS32410 8c5c3cb0aab7ce652ebdb22164628564 464 Pfam PF07969 Amidohydrolase family 186 455 2.8E-23 T 09-03-2017 IPR013108 Amidohydrolase 3 TK78_RS32410 8c5c3cb0aab7ce652ebdb22164628564 464 SUPERFAMILY SSF51556 120 426 1.42E-62 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS24305 c007f4430049c31af3468066d8708fd1 114 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 15 30 5.9E-12 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS24305 c007f4430049c31af3468066d8708fd1 114 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 47 62 5.9E-12 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS24305 c007f4430049c31af3468066d8708fd1 114 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 62 77 5.9E-12 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS24305 c007f4430049c31af3468066d8708fd1 114 SUPERFAMILY SSF46785 9 87 2.1E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS24305 c007f4430049c31af3468066d8708fd1 114 SMART SM00418 13 91 2.6E-23 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS24305 c007f4430049c31af3468066d8708fd1 114 Pfam PF12840 Helix-turn-helix domain 13 69 3.8E-14 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS24305 c007f4430049c31af3468066d8708fd1 114 Gene3D G3DSA:1.10.10.10 8 95 2.7E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS11765 3f9be0009a20a9f15c4eef30990bee36 607 Gene3D G3DSA:3.90.228.20 328 606 6.4E-104 T 09-03-2017 IPR013035 Phosphoenolpyruvate carboxykinase, C-terminal GO:0004611|GO:0006094|GO:0017076 Reactome: R-HSA-70263 TK78_RS11765 3f9be0009a20a9f15c4eef30990bee36 607 Gene3D G3DSA:3.90.228.20 247 316 1.5E-33 T 09-03-2017 IPR013035 Phosphoenolpyruvate carboxykinase, C-terminal GO:0004611|GO:0006094|GO:0017076 Reactome: R-HSA-70263 TK78_RS11765 3f9be0009a20a9f15c4eef30990bee36 607 SUPERFAMILY SSF53795 247 606 2.52E-160 T 09-03-2017 TK78_RS11765 3f9be0009a20a9f15c4eef30990bee36 607 Gene3D G3DSA:3.40.449.10 11 246 2.9E-98 T 09-03-2017 IPR008210 Phosphoenolpyruvate carboxykinase, N-terminal GO:0004611|GO:0006094|GO:0017076 Reactome: R-HSA-70263 TK78_RS11765 3f9be0009a20a9f15c4eef30990bee36 607 Pfam PF00821 Phosphoenolpyruvate carboxykinase 20 606 1.8E-284 T 09-03-2017 IPR008209 Phosphoenolpyruvate carboxykinase, GTP-utilising GO:0004611|GO:0005525|GO:0006094 KEGG: 00010+4.1.1.32|KEGG: 00020+4.1.1.32|KEGG: 00620+4.1.1.32|MetaCyc: PWY-7383|Reactome: R-HSA-70263 TK78_RS11765 3f9be0009a20a9f15c4eef30990bee36 607 Hamap MF_00452 Phosphoenolpyruvate carboxykinase [GTP] [pckG]. 9 607 52.337 T 09-03-2017 IPR008209 Phosphoenolpyruvate carboxykinase, GTP-utilising GO:0004611|GO:0005525|GO:0006094 KEGG: 00010+4.1.1.32|KEGG: 00020+4.1.1.32|KEGG: 00620+4.1.1.32|MetaCyc: PWY-7383|Reactome: R-HSA-70263 TK78_RS11765 3f9be0009a20a9f15c4eef30990bee36 607 PIRSF PIRSF001348 3 607 7.3E-282 T 09-03-2017 IPR008209 Phosphoenolpyruvate carboxykinase, GTP-utilising GO:0004611|GO:0005525|GO:0006094 KEGG: 00010+4.1.1.32|KEGG: 00020+4.1.1.32|KEGG: 00620+4.1.1.32|MetaCyc: PWY-7383|Reactome: R-HSA-70263 TK78_RS11765 3f9be0009a20a9f15c4eef30990bee36 607 ProSitePatterns PS00505 Phosphoenolpyruvate carboxykinase (GTP) signature. 271 279 - T 09-03-2017 IPR018091 Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site GO:0004613 KEGG: 00010+4.1.1.32|KEGG: 00020+4.1.1.32|KEGG: 00620+4.1.1.32|MetaCyc: PWY-7383|Reactome: R-HSA-70263 TK78_RS11765 3f9be0009a20a9f15c4eef30990bee36 607 SUPERFAMILY SSF68923 11 246 1.78E-97 T 09-03-2017 IPR008210 Phosphoenolpyruvate carboxykinase, N-terminal GO:0004611|GO:0006094|GO:0017076 Reactome: R-HSA-70263 TK78_RS26380 cb7527ea1b132c0064a58c84561856f8 347 ProSitePatterns PS00356 LacI-type HTH domain signature. 14 32 - T 09-03-2017 TK78_RS26380 cb7527ea1b132c0064a58c84561856f8 347 Gene3D G3DSA:3.40.50.2300 60 186 1.8E-32 T 09-03-2017 TK78_RS26380 cb7527ea1b132c0064a58c84561856f8 347 SMART SM00354 11 78 1.6E-20 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS26380 cb7527ea1b132c0064a58c84561856f8 347 Gene3D G3DSA:3.40.50.2300 187 322 8.9E-44 T 09-03-2017 TK78_RS26380 cb7527ea1b132c0064a58c84561856f8 347 SUPERFAMILY SSF53822 68 343 9.24E-66 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS26380 cb7527ea1b132c0064a58c84561856f8 347 Pfam PF13377 Periplasmic binding protein-like domain 181 342 5.8E-36 T 09-03-2017 TK78_RS26380 cb7527ea1b132c0064a58c84561856f8 347 Gene3D G3DSA:1.10.260.40 12 56 1.4E-16 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS26380 cb7527ea1b132c0064a58c84561856f8 347 SUPERFAMILY SSF47413 12 58 8.44E-11 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS26380 cb7527ea1b132c0064a58c84561856f8 347 Pfam PF00356 Bacterial regulatory proteins, lacI family 14 56 5.1E-14 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS03615 ebbcc63feceb3be8bc59fe2ebce16a6a 123 Gene3D G3DSA:1.10.10.10 59 100 1.8E-4 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS03615 ebbcc63feceb3be8bc59fe2ebce16a6a 123 Pfam PF05331 Protein of unknown function (DUF742) 17 123 1.2E-36 T 09-03-2017 IPR007995 Protein of unknown function DUF742 TK78_RS34100 865409fb649d7e1b0c13911d7e71d44d 293 Gene3D G3DSA:3.40.190.10 136 237 1.1E-12 T 09-03-2017 TK78_RS34100 865409fb649d7e1b0c13911d7e71d44d 293 SUPERFAMILY SSF53850 14 284 5.25E-40 T 09-03-2017 TK78_RS34100 865409fb649d7e1b0c13911d7e71d44d 293 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3 58 284 1.6E-36 T 09-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF TK78_RS34100 865409fb649d7e1b0c13911d7e71d44d 293 SMART SM00062 57 286 2.5E-23 T 09-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF TK78_RS34100 865409fb649d7e1b0c13911d7e71d44d 293 Gene3D G3DSA:3.40.190.10 242 283 3.3E-19 T 09-03-2017 TK78_RS34100 865409fb649d7e1b0c13911d7e71d44d 293 Gene3D G3DSA:3.40.190.10 56 135 3.3E-19 T 09-03-2017 TK78_RS12285 33d0e1a2d509addf0bff0db4dd8179ae 711 Pfam PF00702 haloacid dehalogenase-like hydrolase 325 558 1.2E-31 T 09-03-2017 TK78_RS12285 33d0e1a2d509addf0bff0db4dd8179ae 711 Pfam PF00122 E1-E2 ATPase 92 319 5.3E-42 T 09-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 TK78_RS12285 33d0e1a2d509addf0bff0db4dd8179ae 711 ProSitePatterns PS00154 E1-E2 ATPases phosphorylation site. 330 336 - T 09-03-2017 IPR018303 P-type ATPase, phosphorylation site Reactome: R-HSA-936837 TK78_RS12285 33d0e1a2d509addf0bff0db4dd8179ae 711 TIGRFAM TIGR01497 kdpB: K+-transporting ATPase, B subunit 33 705 0.0 T 09-03-2017 IPR006391 P-type ATPase, B chain, subfamily IA GO:0005524|GO:0006813|GO:0008556|GO:0016021 TK78_RS12285 33d0e1a2d509addf0bff0db4dd8179ae 711 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 399 629 1.5E-41 T 09-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 TK78_RS12285 33d0e1a2d509addf0bff0db4dd8179ae 711 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 92 365 2.9E-27 T 09-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 TK78_RS12285 33d0e1a2d509addf0bff0db4dd8179ae 711 SUPERFAMILY SSF81653 134 228 2.48E-20 T 09-03-2017 TK78_RS12285 33d0e1a2d509addf0bff0db4dd8179ae 711 Gene3D G3DSA:3.40.50.1000 472 591 1.8E-37 T 09-03-2017 IPR023214 HAD-like domain TK78_RS12285 33d0e1a2d509addf0bff0db4dd8179ae 711 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 491 501 3.8E-25 T 09-03-2017 TK78_RS12285 33d0e1a2d509addf0bff0db4dd8179ae 711 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 175 189 3.8E-25 T 09-03-2017 TK78_RS12285 33d0e1a2d509addf0bff0db4dd8179ae 711 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 328 342 3.8E-25 T 09-03-2017 TK78_RS12285 33d0e1a2d509addf0bff0db4dd8179ae 711 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 567 579 3.8E-25 T 09-03-2017 TK78_RS12285 33d0e1a2d509addf0bff0db4dd8179ae 711 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 544 563 3.8E-25 T 09-03-2017 TK78_RS12285 33d0e1a2d509addf0bff0db4dd8179ae 711 SUPERFAMILY SSF56784 375 432 2.92E-38 T 09-03-2017 IPR023214 HAD-like domain TK78_RS12285 33d0e1a2d509addf0bff0db4dd8179ae 711 SUPERFAMILY SSF56784 467 587 2.92E-38 T 09-03-2017 IPR023214 HAD-like domain TK78_RS12285 33d0e1a2d509addf0bff0db4dd8179ae 711 SUPERFAMILY SSF56784 316 340 2.92E-38 T 09-03-2017 IPR023214 HAD-like domain TK78_RS12285 33d0e1a2d509addf0bff0db4dd8179ae 711 Hamap MF_00285 Potassium-transporting ATPase ATP-binding subunit [kdpB]. 34 708 40.765 T 09-03-2017 IPR006391 P-type ATPase, B chain, subfamily IA GO:0005524|GO:0006813|GO:0008556|GO:0016021 TK78_RS12285 33d0e1a2d509addf0bff0db4dd8179ae 711 SUPERFAMILY SSF81665 229 322 1.57E-12 T 09-03-2017 TK78_RS12285 33d0e1a2d509addf0bff0db4dd8179ae 711 SUPERFAMILY SSF81665 57 123 1.57E-12 T 09-03-2017 TK78_RS12285 33d0e1a2d509addf0bff0db4dd8179ae 711 Gene3D G3DSA:3.40.1110.10 339 471 5.9E-49 T 09-03-2017 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 Reactome: R-HSA-936837 TK78_RS12285 33d0e1a2d509addf0bff0db4dd8179ae 711 Gene3D G3DSA:2.70.150.10 60 229 6.9E-23 T 09-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 TK78_RS18405 053a5bcfbdd0a23cb575539beae6d189 352 Gene3D G3DSA:3.30.420.40 2 141 5.2E-43 T 09-03-2017 TK78_RS18405 053a5bcfbdd0a23cb575539beae6d189 352 TIGRFAM TIGR00329 gcp_kae1: metallohydrolase, glycoprotease/Kae1 family 3 310 4.9E-94 T 09-03-2017 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 TK78_RS18405 053a5bcfbdd0a23cb575539beae6d189 352 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 74 94 1.9E-48 T 09-03-2017 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 TK78_RS18405 053a5bcfbdd0a23cb575539beae6d189 352 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 267 276 1.9E-48 T 09-03-2017 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 TK78_RS18405 053a5bcfbdd0a23cb575539beae6d189 352 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 3 16 1.9E-48 T 09-03-2017 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 TK78_RS18405 053a5bcfbdd0a23cb575539beae6d189 352 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 154 175 1.9E-48 T 09-03-2017 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 TK78_RS18405 053a5bcfbdd0a23cb575539beae6d189 352 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 129 141 1.9E-48 T 09-03-2017 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 TK78_RS18405 053a5bcfbdd0a23cb575539beae6d189 352 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 95 114 1.9E-48 T 09-03-2017 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 TK78_RS18405 053a5bcfbdd0a23cb575539beae6d189 352 TIGRFAM TIGR03723 T6A_TsaD_YgjD: tRNA threonylcarbamoyl adenosine modification protein TsaD 2 315 3.6E-122 T 09-03-2017 IPR022450 tRNA N6-adenosine threonylcarbamoyltransferase, TsaD GO:0002949|GO:0004222 KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 TK78_RS18405 053a5bcfbdd0a23cb575539beae6d189 352 SUPERFAMILY SSF53067 2 312 8.63E-39 T 09-03-2017 TK78_RS18405 053a5bcfbdd0a23cb575539beae6d189 352 Hamap MF_01445 tRNA N6-adenosine threonylcarbamoyltransferase [tsaD]. 1 336 59.368 T 09-03-2017 IPR022450 tRNA N6-adenosine threonylcarbamoyltransferase, TsaD GO:0002949|GO:0004222 KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 TK78_RS18405 053a5bcfbdd0a23cb575539beae6d189 352 Gene3D G3DSA:3.40.50.450 252 288 7.5E-4 T 09-03-2017 TK78_RS18405 053a5bcfbdd0a23cb575539beae6d189 352 Pfam PF00814 Glycoprotease family 22 310 2.0E-93 T 09-03-2017 IPR000905 Gcp-like domain KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 TK78_RS09530 0e1559ee24844041bd9c2015cb2041d9 220 SUPERFAMILY SSF46894 119 218 1.62E-28 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS09530 0e1559ee24844041bd9c2015cb2041d9 220 SUPERFAMILY SSF52172 1 118 1.57E-39 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS09530 0e1559ee24844041bd9c2015cb2041d9 220 Gene3D G3DSA:3.40.50.2300 1 120 1.3E-39 T 09-03-2017 TK78_RS09530 0e1559ee24844041bd9c2015cb2041d9 220 Pfam PF00486 Transcriptional regulatory protein, C terminal 147 217 2.7E-24 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS09530 0e1559ee24844041bd9c2015cb2041d9 220 SMART SM00862 146 217 4.5E-27 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS09530 0e1559ee24844041bd9c2015cb2041d9 220 Pfam PF00072 Response regulator receiver domain 4 112 4.3E-26 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS09530 0e1559ee24844041bd9c2015cb2041d9 220 Gene3D G3DSA:1.10.10.10 123 219 1.3E-32 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS09530 0e1559ee24844041bd9c2015cb2041d9 220 SMART SM00448 1 112 3.1E-41 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS22320 48af697294b452745715bc3b8d4bae1d 380 Gene3D G3DSA:1.10.10.10 284 369 1.6E-14 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS22320 48af697294b452745715bc3b8d4bae1d 380 Pfam PF00486 Transcriptional regulatory protein, C terminal 305 368 2.3E-12 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS22320 48af697294b452745715bc3b8d4bae1d 380 SUPERFAMILY SSF46894 281 368 1.47E-13 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS22320 48af697294b452745715bc3b8d4bae1d 380 SMART SM00862 297 368 2.6E-13 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS22320 48af697294b452745715bc3b8d4bae1d 380 SUPERFAMILY SSF69618 13 274 9.16E-55 T 09-03-2017 IPR003754 Tetrapyrrole biosynthesis, uroporphyrinogen III synthase GO:0004852|GO:0033014 KEGG: 00860+4.2.1.75|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS22320 48af697294b452745715bc3b8d4bae1d 380 Gene3D G3DSA:3.40.50.10090 10 139 3.8E-30 T 09-03-2017 TK78_RS22320 48af697294b452745715bc3b8d4bae1d 380 Gene3D G3DSA:3.40.50.10090 140 274 5.2E-36 T 09-03-2017 TK78_RS22320 48af697294b452745715bc3b8d4bae1d 380 Pfam PF02602 Uroporphyrinogen-III synthase HemD 26 267 7.7E-38 T 09-03-2017 IPR003754 Tetrapyrrole biosynthesis, uroporphyrinogen III synthase GO:0004852|GO:0033014 KEGG: 00860+4.2.1.75|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS21925 4d43fba1caef98de1fcba455902da9b2 509 TIGRFAM TIGR00350 lytR_cpsA_psr: cell envelope-related function transcriptional attenuator common domain 112 275 2.3E-36 T 09-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain TK78_RS21925 4d43fba1caef98de1fcba455902da9b2 509 Pfam PF03816 Cell envelope-related transcriptional attenuator domain 112 275 1.1E-41 T 09-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain TK78_RS21925 4d43fba1caef98de1fcba455902da9b2 509 Pfam PF13399 LytR cell envelope-related transcriptional attenuator 389 480 3.4E-13 T 09-03-2017 IPR027381 Putative LytR/CpsA/Psr regulator, C-terminal domain TK78_RS02830 1756a7b66b34a192ccda3fa97217840c 648 PIRSF PIRSF014753 1 633 2.1E-137 T 09-03-2017 IPR016624 Uncharacterised conserved protein UCP014753 TK78_RS02830 1756a7b66b34a192ccda3fa97217840c 648 Pfam PF10022 Uncharacterized protein conserved in bacteria (DUF2264) 25 374 8.5E-100 T 09-03-2017 IPR016624 Uncharacterised conserved protein UCP014753 TK78_RS04620 ad4123ee6ecd8ea902948244bc3ea755 740 TIGRFAM TIGR00178 monomer_idh: isocitrate dehydrogenase, NADP-dependent 3 739 0.0 T 09-03-2017 IPR004436 Isocitrate dehydrogenase NADP-dependent, monomeric GO:0004450|GO:0006099|GO:0055114 KEGG: 00020+1.1.1.42|KEGG: 00480+1.1.1.42|KEGG: 00720+1.1.1.42|MetaCyc: PWY-5913|MetaCyc: PWY-6549|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7124|MetaCyc: PWY-7254|MetaCyc: PWY-7268 TK78_RS04620 ad4123ee6ecd8ea902948244bc3ea755 740 SUPERFAMILY SSF53659 4 739 0.0 T 09-03-2017 TK78_RS04620 ad4123ee6ecd8ea902948244bc3ea755 740 PIRSF PIRSF009407 1 740 0.0 T 09-03-2017 IPR004436 Isocitrate dehydrogenase NADP-dependent, monomeric GO:0004450|GO:0006099|GO:0055114 KEGG: 00020+1.1.1.42|KEGG: 00480+1.1.1.42|KEGG: 00720+1.1.1.42|MetaCyc: PWY-5913|MetaCyc: PWY-6549|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7124|MetaCyc: PWY-7254|MetaCyc: PWY-7268 TK78_RS04620 ad4123ee6ecd8ea902948244bc3ea755 740 Gene3D G3DSA:3.40.718.10 537 643 2.7E-33 T 09-03-2017 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 Reactome: R-HSA-71403 TK78_RS04620 ad4123ee6ecd8ea902948244bc3ea755 740 Gene3D G3DSA:3.40.718.10 146 287 2.7E-33 T 09-03-2017 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 Reactome: R-HSA-71403 TK78_RS04620 ad4123ee6ecd8ea902948244bc3ea755 740 Gene3D G3DSA:3.40.718.10 338 361 2.7E-33 T 09-03-2017 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 Reactome: R-HSA-71403 TK78_RS04620 ad4123ee6ecd8ea902948244bc3ea755 740 Pfam PF03971 Monomeric isocitrate dehydrogenase 5 736 0.0 T 09-03-2017 IPR004436 Isocitrate dehydrogenase NADP-dependent, monomeric GO:0004450|GO:0006099|GO:0055114 KEGG: 00020+1.1.1.42|KEGG: 00480+1.1.1.42|KEGG: 00720+1.1.1.42|MetaCyc: PWY-5913|MetaCyc: PWY-6549|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7124|MetaCyc: PWY-7254|MetaCyc: PWY-7268 TK78_RS29010 1ba4439386f735f7959c195b1162962a 359 Gene3D G3DSA:3.40.50.720 182 301 5.2E-41 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS29010 1ba4439386f735f7959c195b1162962a 359 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 59 73 - T 09-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 TK78_RS29010 1ba4439386f735f7959c195b1162962a 359 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 26 114 5.1E-21 T 09-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 TK78_RS29010 1ba4439386f735f7959c195b1162962a 359 Gene3D G3DSA:3.90.180.10 2 181 2.3E-52 T 09-03-2017 IPR011032 GroES-like TK78_RS29010 1ba4439386f735f7959c195b1162962a 359 Pfam PF00107 Zinc-binding dehydrogenase 189 313 2.8E-30 T 09-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 TK78_RS29010 1ba4439386f735f7959c195b1162962a 359 SUPERFAMILY SSF51735 151 323 1.21E-45 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS29010 1ba4439386f735f7959c195b1162962a 359 SUPERFAMILY SSF50129 2 185 3.2E-48 T 09-03-2017 IPR011032 GroES-like TK78_RS29010 1ba4439386f735f7959c195b1162962a 359 SMART SM00829 11 357 1.6E-10 T 09-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 TK78_RS31475 dd7cb88b6ecedd036d272b94218e58e0 276 Gene3D G3DSA:3.40.50.1820 8 273 3.9E-46 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS31475 dd7cb88b6ecedd036d272b94218e58e0 276 PRINTS PR00111 Alpha/beta hydrolase fold signature 54 69 4.0E-8 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS31475 dd7cb88b6ecedd036d272b94218e58e0 276 PRINTS PR00111 Alpha/beta hydrolase fold signature 100 113 4.0E-8 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS31475 dd7cb88b6ecedd036d272b94218e58e0 276 PRINTS PR00111 Alpha/beta hydrolase fold signature 221 235 4.0E-8 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS31475 dd7cb88b6ecedd036d272b94218e58e0 276 Pfam PF12697 Alpha/beta hydrolase family 31 269 1.3E-21 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS31475 dd7cb88b6ecedd036d272b94218e58e0 276 SUPERFAMILY SSF53474 11 273 2.52E-47 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS26315 13e1f48286cd16b0e74463d381e3ce4a 259 SMART SM00345 10 69 2.5E-16 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS26315 13e1f48286cd16b0e74463d381e3ce4a 259 Pfam PF07702 UTRA domain 101 233 1.5E-15 T 09-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 TK78_RS26315 13e1f48286cd16b0e74463d381e3ce4a 259 SMART SM00866 98 242 6.2E-9 T 09-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 TK78_RS26315 13e1f48286cd16b0e74463d381e3ce4a 259 Pfam PF00392 Bacterial regulatory proteins, gntR family 6 69 6.1E-17 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS26315 13e1f48286cd16b0e74463d381e3ce4a 259 SUPERFAMILY SSF46785 4 79 8.66E-18 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS26315 13e1f48286cd16b0e74463d381e3ce4a 259 Gene3D G3DSA:3.40.1410.10 71 245 1.3E-50 T 09-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain TK78_RS26315 13e1f48286cd16b0e74463d381e3ce4a 259 Gene3D G3DSA:1.10.10.10 7 70 7.5E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS26315 13e1f48286cd16b0e74463d381e3ce4a 259 SUPERFAMILY SSF64288 57 248 1.04E-29 T 09-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain TK78_RS14675 55d0ba91b214a16845abb1bba7b87547 127 Gene3D G3DSA:2.40.50.140 3 64 3.5E-24 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS14675 55d0ba91b214a16845abb1bba7b87547 127 PRINTS PR00050 Cold shock protein signature 38 56 7.8E-14 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS14675 55d0ba91b214a16845abb1bba7b87547 127 PRINTS PR00050 Cold shock protein signature 24 33 7.8E-14 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS14675 55d0ba91b214a16845abb1bba7b87547 127 PRINTS PR00050 Cold shock protein signature 4 19 7.8E-14 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS14675 55d0ba91b214a16845abb1bba7b87547 127 SMART SM00357 3 65 3.1E-21 T 09-03-2017 IPR011129 Cold shock protein GO:0003676 TK78_RS14675 55d0ba91b214a16845abb1bba7b87547 127 ProSitePatterns PS00352 'Cold-shock' domain signature. 15 33 - T 09-03-2017 IPR019844 Cold-shock conserved site TK78_RS14675 55d0ba91b214a16845abb1bba7b87547 127 SUPERFAMILY SSF50249 2 65 1.35E-18 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS14675 55d0ba91b214a16845abb1bba7b87547 127 Pfam PF00313 'Cold-shock' DNA-binding domain 3 63 1.9E-20 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS16365 d159c4d76dd0803a71ec9105b9dde423 121 SUPERFAMILY SSF50729 3 120 2.34E-42 T 09-03-2017 IPR011993 PH domain-like TK78_RS16365 d159c4d76dd0803a71ec9105b9dde423 121 Pfam PF08000 Bacterial PH domain 3 118 2.5E-46 T 09-03-2017 IPR012544 Bacterial Pleckstrin homology domain TK78_RS16365 d159c4d76dd0803a71ec9105b9dde423 121 Gene3D G3DSA:2.30.29.50 3 100 4.4E-41 T 09-03-2017 IPR012544 Bacterial Pleckstrin homology domain TK78_RS24255 e06839ad833b560ebca567ffceee6d5e 483 Pfam PF00860 Permease family 39 435 1.5E-28 T 09-03-2017 IPR006043 Xanthine/uracil/vitamin C permease GO:0005215|GO:0006810|GO:0016020|GO:0055085 TK78_RS06605 aef17583af081f2a0511c512b893ce54 352 Gene3D G3DSA:3.10.310.10 10 162 1.2E-51 T 09-03-2017 TK78_RS06605 aef17583af081f2a0511c512b893ce54 352 PIRSF PIRSF029792 5 352 5.9E-87 T 09-03-2017 IPR008794 Proline racemase family TK78_RS06605 aef17583af081f2a0511c512b893ce54 352 Gene3D G3DSA:3.10.310.10 163 339 1.8E-60 T 09-03-2017 TK78_RS06605 aef17583af081f2a0511c512b893ce54 352 Pfam PF05544 Proline racemase 14 349 2.0E-83 T 09-03-2017 IPR008794 Proline racemase family TK78_RS06605 aef17583af081f2a0511c512b893ce54 352 SUPERFAMILY SSF54506 9 349 6.5E-81 T 09-03-2017 TK78_RS00830 0514e89cf7f8f9629972a2ece3666595 177 Gene3D G3DSA:3.40.50.300 8 173 1.3E-16 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS00830 0514e89cf7f8f9629972a2ece3666595 177 Pfam PF13671 AAA domain 10 141 5.8E-10 T 09-03-2017 TK78_RS00830 0514e89cf7f8f9629972a2ece3666595 177 SUPERFAMILY SSF52540 7 176 3.35E-18 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31105 557911f8b72539a9d4c7723214853327 920 SUPERFAMILY SSF46894 859 917 2.99E-16 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS31105 557911f8b72539a9d4c7723214853327 920 Pfam PF00196 Bacterial regulatory proteins, luxR family 865 918 3.7E-16 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS31105 557911f8b72539a9d4c7723214853327 920 SUPERFAMILY SSF52540 110 220 1.31E-8 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31105 557911f8b72539a9d4c7723214853327 920 SUPERFAMILY SSF52540 6 80 1.31E-8 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31105 557911f8b72539a9d4c7723214853327 920 Pfam PF13191 AAA ATPase domain 9 165 7.4E-13 T 09-03-2017 TK78_RS31105 557911f8b72539a9d4c7723214853327 920 SMART SM00421 863 920 2.3E-20 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS31105 557911f8b72539a9d4c7723214853327 920 Gene3D G3DSA:1.25.40.10 540 772 1.6E-5 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS31105 557911f8b72539a9d4c7723214853327 920 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 866 880 2.8E-10 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS31105 557911f8b72539a9d4c7723214853327 920 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 896 908 2.8E-10 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS31105 557911f8b72539a9d4c7723214853327 920 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 880 896 2.8E-10 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS31105 557911f8b72539a9d4c7723214853327 920 Gene3D G3DSA:1.10.10.10 859 917 3.4E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS31105 557911f8b72539a9d4c7723214853327 920 ProSitePatterns PS00622 LuxR-type HTH domain signature. 880 907 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS25685 7c2b8557851547b850ce856c19f234c3 273 SUPERFAMILY SSF56655 9 269 7.85E-39 T 09-03-2017 TK78_RS25685 7c2b8557851547b850ce856c19f234c3 273 Gene3D G3DSA:3.30.540.10 11 134 3.0E-21 T 09-03-2017 TK78_RS25685 7c2b8557851547b850ce856c19f234c3 273 PRINTS PR00377 Inositol monophosphatase superfamily signature 85 101 2.7E-16 T 09-03-2017 IPR000760 Inositol monophosphatase GO:0046854 TK78_RS25685 7c2b8557851547b850ce856c19f234c3 273 PRINTS PR00377 Inositol monophosphatase superfamily signature 42 62 2.7E-16 T 09-03-2017 IPR000760 Inositol monophosphatase GO:0046854 TK78_RS25685 7c2b8557851547b850ce856c19f234c3 273 PRINTS PR00377 Inositol monophosphatase superfamily signature 64 80 2.7E-16 T 09-03-2017 IPR000760 Inositol monophosphatase GO:0046854 TK78_RS25685 7c2b8557851547b850ce856c19f234c3 273 PRINTS PR00377 Inositol monophosphatase superfamily signature 179 200 2.7E-16 T 09-03-2017 IPR000760 Inositol monophosphatase GO:0046854 TK78_RS25685 7c2b8557851547b850ce856c19f234c3 273 PRINTS PR00377 Inositol monophosphatase superfamily signature 213 237 2.7E-16 T 09-03-2017 IPR000760 Inositol monophosphatase GO:0046854 TK78_RS25685 7c2b8557851547b850ce856c19f234c3 273 Gene3D G3DSA:3.40.190.80 186 266 3.5E-12 T 09-03-2017 TK78_RS25685 7c2b8557851547b850ce856c19f234c3 273 Pfam PF00459 Inositol monophosphatase family 10 263 4.7E-31 T 09-03-2017 IPR000760 Inositol monophosphatase GO:0046854 TK78_RS01475 a22afe5ab066e2d817a5e3570cff79d7 312 ProSitePatterns PS00146 Beta-lactamase class-A active site. 89 104 - T 09-03-2017 IPR023650 Beta-lactamase, class-A active site KEGG: 00311+3.5.2.6 TK78_RS01475 a22afe5ab066e2d817a5e3570cff79d7 312 PRINTS PR00118 Beta-lactamase class A signature 225 240 8.0E-68 T 09-03-2017 IPR000871 Beta-lactamase, class-A GO:0008800|GO:0030655|GO:0046677 KEGG: 00311+3.5.2.6 TK78_RS01475 a22afe5ab066e2d817a5e3570cff79d7 312 PRINTS PR00118 Beta-lactamase class A signature 87 104 8.0E-68 T 09-03-2017 IPR000871 Beta-lactamase, class-A GO:0008800|GO:0030655|GO:0046677 KEGG: 00311+3.5.2.6 TK78_RS01475 a22afe5ab066e2d817a5e3570cff79d7 312 PRINTS PR00118 Beta-lactamase class A signature 189 214 8.0E-68 T 09-03-2017 IPR000871 Beta-lactamase, class-A GO:0008800|GO:0030655|GO:0046677 KEGG: 00311+3.5.2.6 TK78_RS01475 a22afe5ab066e2d817a5e3570cff79d7 312 PRINTS PR00118 Beta-lactamase class A signature 127 152 8.0E-68 T 09-03-2017 IPR000871 Beta-lactamase, class-A GO:0008800|GO:0030655|GO:0046677 KEGG: 00311+3.5.2.6 TK78_RS01475 a22afe5ab066e2d817a5e3570cff79d7 312 PRINTS PR00118 Beta-lactamase class A signature 163 187 8.0E-68 T 09-03-2017 IPR000871 Beta-lactamase, class-A GO:0008800|GO:0030655|GO:0046677 KEGG: 00311+3.5.2.6 TK78_RS01475 a22afe5ab066e2d817a5e3570cff79d7 312 PRINTS PR00118 Beta-lactamase class A signature 242 257 8.0E-68 T 09-03-2017 IPR000871 Beta-lactamase, class-A GO:0008800|GO:0030655|GO:0046677 KEGG: 00311+3.5.2.6 TK78_RS01475 a22afe5ab066e2d817a5e3570cff79d7 312 PRINTS PR00118 Beta-lactamase class A signature 56 80 8.0E-68 T 09-03-2017 IPR000871 Beta-lactamase, class-A GO:0008800|GO:0030655|GO:0046677 KEGG: 00311+3.5.2.6 TK78_RS01475 a22afe5ab066e2d817a5e3570cff79d7 312 SUPERFAMILY SSF56601 57 308 2.47E-74 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS01475 a22afe5ab066e2d817a5e3570cff79d7 312 Gene3D G3DSA:3.40.710.10 57 310 4.1E-100 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS01475 a22afe5ab066e2d817a5e3570cff79d7 312 Pfam PF13354 Beta-lactamase enzyme family 76 283 2.4E-37 T 09-03-2017 TK78_RS27490 f7fbe4c78133be15d292bbed4a03181e 249 Pfam PF00378 Enoyl-CoA hydratase/isomerase 12 211 5.5E-37 T 09-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 TK78_RS27490 f7fbe4c78133be15d292bbed4a03181e 249 SUPERFAMILY SSF52096 11 231 3.42E-54 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS27490 f7fbe4c78133be15d292bbed4a03181e 249 Gene3D G3DSA:3.90.226.10 11 223 3.3E-53 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS01825 a7fb28859c53a08b4c3f553a82520535 360 Gene3D G3DSA:3.40.50.2300 178 319 6.9E-30 T 09-03-2017 TK78_RS01825 a7fb28859c53a08b4c3f553a82520535 360 TIGRFAM TIGR02637 RhaS: rhamnose ABC transporter, rhamnose-binding protein 59 360 5.0E-140 T 09-03-2017 IPR013459 Rhamnose-binding protein GO:0015762 TK78_RS01825 a7fb28859c53a08b4c3f553a82520535 360 Gene3D G3DSA:3.40.50.2300 53 177 6.1E-30 T 09-03-2017 TK78_RS01825 a7fb28859c53a08b4c3f553a82520535 360 SUPERFAMILY SSF53822 55 360 7.07E-67 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS01825 a7fb28859c53a08b4c3f553a82520535 360 Pfam PF13407 Periplasmic binding protein domain 59 317 1.6E-57 T 09-03-2017 IPR025997 Periplasmic binding protein TK78_RS06190 b2c1625d8bf7087e0e50c2636c8f5dbd 805 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 520 622 1.9E-7 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS06190 b2c1625d8bf7087e0e50c2636c8f5dbd 805 SMART SM00304 325 402 2.7E-4 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS06190 b2c1625d8bf7087e0e50c2636c8f5dbd 805 SMART SM00387 515 624 4.2E-8 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS06190 b2c1625d8bf7087e0e50c2636c8f5dbd 805 Gene3D G3DSA:3.30.565.10 519 623 1.3E-12 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS06190 b2c1625d8bf7087e0e50c2636c8f5dbd 805 Pfam PF00672 HAMP domain 307 398 1.6E-12 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS06190 b2c1625d8bf7087e0e50c2636c8f5dbd 805 Pfam PF08376 Nitrate and nitrite sensing 52 287 1.9E-27 T 09-03-2017 IPR013587 Nitrate/nitrite sensing protein TK78_RS06190 b2c1625d8bf7087e0e50c2636c8f5dbd 805 SUPERFAMILY SSF55874 515 623 1.83E-17 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS03315 61b49ff94100da86fc5cee0b67f74601 725 Pfam PF00378 Enoyl-CoA hydratase/isomerase 14 206 1.6E-30 T 09-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 TK78_RS03315 61b49ff94100da86fc5cee0b67f74601 725 SUPERFAMILY SSF48179 503 644 5.36E-15 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS03315 61b49ff94100da86fc5cee0b67f74601 725 SUPERFAMILY SSF52096 2 314 8.4E-58 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS03315 61b49ff94100da86fc5cee0b67f74601 725 Gene3D G3DSA:3.90.226.10 3 207 9.3E-53 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS03315 61b49ff94100da86fc5cee0b67f74601 725 Gene3D G3DSA:3.90.226.10 241 300 9.3E-53 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS03315 61b49ff94100da86fc5cee0b67f74601 725 Gene3D G3DSA:3.40.50.720 318 505 4.8E-59 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS03315 61b49ff94100da86fc5cee0b67f74601 725 Gene3D G3DSA:1.10.1040.10 506 605 1.3E-10 T 09-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 TK78_RS03315 61b49ff94100da86fc5cee0b67f74601 725 SUPERFAMILY SSF51735 320 502 4.68E-58 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS03315 61b49ff94100da86fc5cee0b67f74601 725 SUPERFAMILY SSF48179 632 725 1.79E-17 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS03315 61b49ff94100da86fc5cee0b67f74601 725 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 323 501 3.6E-64 T 09-03-2017 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS03315 61b49ff94100da86fc5cee0b67f74601 725 Gene3D G3DSA:1.10.1040.10 646 723 4.7E-9 T 09-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 TK78_RS03315 61b49ff94100da86fc5cee0b67f74601 725 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 504 604 3.1E-17 T 09-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS03700 412bc18627bffcf1eb9c9a646cda24e8 324 Gene3D G3DSA:3.40.190.100 138 262 6.5E-22 T 09-03-2017 TK78_RS03700 412bc18627bffcf1eb9c9a646cda24e8 324 Gene3D G3DSA:3.40.190.10 263 323 2.7E-13 T 09-03-2017 TK78_RS03700 412bc18627bffcf1eb9c9a646cda24e8 324 Gene3D G3DSA:3.40.190.10 39 137 2.7E-10 T 09-03-2017 TK78_RS03700 412bc18627bffcf1eb9c9a646cda24e8 324 SUPERFAMILY SSF53850 37 322 6.33E-55 T 09-03-2017 TK78_RS03700 412bc18627bffcf1eb9c9a646cda24e8 324 Pfam PF04069 Substrate binding domain of ABC-type glycine betaine transport system 43 311 1.4E-47 T 09-03-2017 IPR007210 ABC-type glycine betaine transport system, substrate-binding domain GO:0005215|GO:0006810 TK78_RS25560 0e58bfe0d19e10b8d4efe2cb6cf7d37e 229 Pfam PF00072 Response regulator receiver domain 5 121 4.2E-26 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS25560 0e58bfe0d19e10b8d4efe2cb6cf7d37e 229 Pfam PF00196 Bacterial regulatory proteins, luxR family 162 216 1.2E-19 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS25560 0e58bfe0d19e10b8d4efe2cb6cf7d37e 229 SMART SM00448 3 120 1.6E-31 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS25560 0e58bfe0d19e10b8d4efe2cb6cf7d37e 229 ProSitePatterns PS00622 LuxR-type HTH domain signature. 176 203 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS25560 0e58bfe0d19e10b8d4efe2cb6cf7d37e 229 Gene3D G3DSA:3.40.50.2300 2 128 2.0E-38 T 09-03-2017 TK78_RS25560 0e58bfe0d19e10b8d4efe2cb6cf7d37e 229 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 176 192 1.1E-14 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS25560 0e58bfe0d19e10b8d4efe2cb6cf7d37e 229 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 192 204 1.1E-14 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS25560 0e58bfe0d19e10b8d4efe2cb6cf7d37e 229 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 162 176 1.1E-14 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS25560 0e58bfe0d19e10b8d4efe2cb6cf7d37e 229 Gene3D G3DSA:1.10.10.10 129 223 3.4E-33 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS25560 0e58bfe0d19e10b8d4efe2cb6cf7d37e 229 SUPERFAMILY SSF52172 3 193 9.66E-33 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS25560 0e58bfe0d19e10b8d4efe2cb6cf7d37e 229 SMART SM00421 159 216 9.1E-26 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS15180 171a4070deff0e00f5e5fe8aaec680b8 591 Pfam PF04183 IucA / IucC family 141 391 3.5E-78 T 09-03-2017 IPR007310 Aerobactin siderophore biosynthesis, IucA/IucC, N-terminal GO:0015343|GO:0019290 TK78_RS15180 171a4070deff0e00f5e5fe8aaec680b8 591 Pfam PF06276 Ferric iron reductase FhuF-like transporter 413 570 2.4E-39 T 09-03-2017 IPR022770 Ferric iron reductase FhuF domain TK78_RS06820 3e6ca9377346f1854956405161aae023 217 SUPERFAMILY SSF51206 25 136 4.98E-21 T 09-03-2017 IPR018490 Cyclic nucleotide-binding-like TK78_RS06820 3e6ca9377346f1854956405161aae023 217 Pfam PF00027 Cyclic nucleotide-binding domain 30 117 1.4E-16 T 09-03-2017 IPR000595 Cyclic nucleotide-binding domain TK78_RS06820 3e6ca9377346f1854956405161aae023 217 Gene3D G3DSA:1.10.10.10 141 212 5.6E-9 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS06820 3e6ca9377346f1854956405161aae023 217 SUPERFAMILY SSF46785 142 213 4.28E-8 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS06820 3e6ca9377346f1854956405161aae023 217 SMART SM00100 8 132 1.2E-14 T 09-03-2017 IPR000595 Cyclic nucleotide-binding domain TK78_RS06820 3e6ca9377346f1854956405161aae023 217 Pfam PF13545 Crp-like helix-turn-helix domain 144 210 2.0E-8 T 09-03-2017 IPR012318 Crp-type HTH domain GO:0003677|GO:0006355 TK78_RS06820 3e6ca9377346f1854956405161aae023 217 Gene3D G3DSA:2.60.120.10 18 135 8.7E-20 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS29510 dd54270e7a46d581bda230db484317df 380 SMART SM00382 51 248 1.9E-18 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS29510 dd54270e7a46d581bda230db484317df 380 SUPERFAMILY SSF52540 41 268 1.49E-74 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29510 dd54270e7a46d581bda230db484317df 380 Gene3D G3DSA:3.40.50.300 36 263 2.1E-77 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29510 dd54270e7a46d581bda230db484317df 380 TIGRFAM TIGR01186 proV: glycine betaine/L-proline transport ATP binding subunit 36 291 3.1E-109 T 09-03-2017 IPR005892 Glycine betaine transport ATP-binding subunit GO:0005524|GO:0016020|GO:0031460 TK78_RS29510 dd54270e7a46d581bda230db484317df 380 Pfam PF00005 ABC transporter 44 190 4.1E-32 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS29510 dd54270e7a46d581bda230db484317df 380 ProSitePatterns PS00211 ABC transporters family signature. 163 177 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS29510 dd54270e7a46d581bda230db484317df 380 Gene3D G3DSA:3.10.580.10 297 351 4.6E-4 T 09-03-2017 TK78_RS24490 79d20c7eb82dbb5c95d69a03f7e5e4c0 1415 Pfam PF10150 Ribonuclease E/G family 768 1040 7.5E-106 T 09-03-2017 IPR019307 RNA-binding protein AU-1/Ribonuclease E/G GO:0003723 TK78_RS24490 79d20c7eb82dbb5c95d69a03f7e5e4c0 1415 TIGRFAM TIGR00757 RNaseEG: ribonuclease, Rne/Rng family 664 1066 8.3E-151 T 09-03-2017 IPR004659 Ribonuclease E/G GO:0003723|GO:0004540|GO:0006396 TK78_RS24490 79d20c7eb82dbb5c95d69a03f7e5e4c0 1415 SMART SM00316 687 766 3.7E-5 T 09-03-2017 IPR022967 RNA-binding domain, S1 TK78_RS24490 79d20c7eb82dbb5c95d69a03f7e5e4c0 1415 SUPERFAMILY SSF50249 689 772 1.67E-14 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS24490 79d20c7eb82dbb5c95d69a03f7e5e4c0 1415 Gene3D G3DSA:2.40.50.140 682 772 1.5E-28 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS26210 e7f9eb77dc50fb26b8feeeb20b6a66d6 1220 PRINTS PR00364 Disease resistance protein signature 392 407 4.5E-5 T 09-03-2017 TK78_RS26210 e7f9eb77dc50fb26b8feeeb20b6a66d6 1220 PRINTS PR00364 Disease resistance protein signature 572 586 4.5E-5 T 09-03-2017 TK78_RS26210 e7f9eb77dc50fb26b8feeeb20b6a66d6 1220 PRINTS PR00364 Disease resistance protein signature 476 490 4.5E-5 T 09-03-2017 TK78_RS26210 e7f9eb77dc50fb26b8feeeb20b6a66d6 1220 SMART SM01043 98 240 9.8E-44 T 09-03-2017 IPR005158 Bacterial transcriptional activator domain TK78_RS26210 e7f9eb77dc50fb26b8feeeb20b6a66d6 1220 Gene3D G3DSA:1.10.10.10 11 94 1.2E-9 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS26210 e7f9eb77dc50fb26b8feeeb20b6a66d6 1220 Gene3D G3DSA:1.25.40.10 938 1112 1.4E-15 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS26210 e7f9eb77dc50fb26b8feeeb20b6a66d6 1220 Pfam PF03704 Bacterial transcriptional activator domain 98 240 8.3E-37 T 09-03-2017 IPR005158 Bacterial transcriptional activator domain TK78_RS26210 e7f9eb77dc50fb26b8feeeb20b6a66d6 1220 SUPERFAMILY SSF48452 929 1063 9.87E-14 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS26210 e7f9eb77dc50fb26b8feeeb20b6a66d6 1220 SUPERFAMILY SSF46894 7 91 3.68E-11 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS26210 e7f9eb77dc50fb26b8feeeb20b6a66d6 1220 SUPERFAMILY SSF52540 368 638 1.9E-16 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS26210 e7f9eb77dc50fb26b8feeeb20b6a66d6 1220 Pfam PF00486 Transcriptional regulatory protein, C terminal 28 90 8.6E-8 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS26210 e7f9eb77dc50fb26b8feeeb20b6a66d6 1220 SUPERFAMILY SSF48452 94 254 3.45E-28 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS26210 e7f9eb77dc50fb26b8feeeb20b6a66d6 1220 SMART SM00862 19 91 1.2E-11 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS01840 e1339ce3a87feb5da369e98dd6adc618 398 ProSitePatterns PS00216 Sugar transport proteins signature 1. 66 82 - T 09-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 TK78_RS01840 e1339ce3a87feb5da369e98dd6adc618 398 Pfam PF07690 Major Facilitator Superfamily 19 292 1.5E-26 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS01840 e1339ce3a87feb5da369e98dd6adc618 398 Gene3D G3DSA:1.20.1250.20 18 191 9.6E-26 T 09-03-2017 TK78_RS01840 e1339ce3a87feb5da369e98dd6adc618 398 Gene3D G3DSA:1.20.1250.20 218 390 3.5E-10 T 09-03-2017 TK78_RS01840 e1339ce3a87feb5da369e98dd6adc618 398 SUPERFAMILY SSF103473 9 393 8.63E-45 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS02155 2f9ba16340976e4f2ef60f0cc32b5280 298 SUPERFAMILY SSF69593 31 208 4.84E-26 T 09-03-2017 TK78_RS02155 2f9ba16340976e4f2ef60f0cc32b5280 298 SMART SM00563 95 207 1.4E-28 T 09-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 TK78_RS02155 2f9ba16340976e4f2ef60f0cc32b5280 298 Pfam PF01553 Acyltransferase 92 204 3.9E-18 T 09-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 TK78_RS02155 2f9ba16340976e4f2ef60f0cc32b5280 298 Gene3D G3DSA:3.40.1130.10 95 190 1.9E-9 T 09-03-2017 TK78_RS27090 a4f9a911196da244fdc059e7b059716a 475 Hamap MF_00639 UDP-N-acetylmuramoylalanine--D-glutamate ligase [murD]. 9 470 33.984 T 09-03-2017 IPR005762 UDP-N-acetylmuramoylalanine-D-glutamate ligase GO:0005524|GO:0005737|GO:0008360|GO:0008764|GO:0051301 KEGG: 00471+6.3.2.9|KEGG: 00550+6.3.2.9|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS27090 a4f9a911196da244fdc059e7b059716a 475 ProSitePatterns PS01011 Folylpolyglutamate synthase signature 1. 119 142 - T 09-03-2017 IPR018109 Folylpolyglutamate synthetase, conserved site GO:0004326|GO:0005524|GO:0009396 Reactome: R-HSA-196757 TK78_RS27090 a4f9a911196da244fdc059e7b059716a 475 SUPERFAMILY SSF53244 327 469 4.58E-39 T 09-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TK78_RS27090 a4f9a911196da244fdc059e7b059716a 475 SUPERFAMILY SSF53623 115 323 3.14E-49 T 09-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 TK78_RS27090 a4f9a911196da244fdc059e7b059716a 475 Gene3D G3DSA:3.40.50.720 5 98 4.9E-21 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS27090 a4f9a911196da244fdc059e7b059716a 475 TIGRFAM TIGR01087 murD: UDP-N-acetylmuramoylalanine--D-glutamate ligase 10 468 5.3E-120 T 09-03-2017 IPR005762 UDP-N-acetylmuramoylalanine-D-glutamate ligase GO:0005524|GO:0005737|GO:0008360|GO:0008764|GO:0051301 KEGG: 00471+6.3.2.9|KEGG: 00550+6.3.2.9|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS27090 a4f9a911196da244fdc059e7b059716a 475 Pfam PF02875 Mur ligase family, glutamate ligase domain 328 394 5.7E-6 T 09-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TK78_RS27090 a4f9a911196da244fdc059e7b059716a 475 Pfam PF08245 Mur ligase middle domain 121 306 2.8E-27 T 09-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 TK78_RS27090 a4f9a911196da244fdc059e7b059716a 475 Gene3D G3DSA:3.90.190.20 327 467 4.2E-46 T 09-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TK78_RS27090 a4f9a911196da244fdc059e7b059716a 475 Gene3D G3DSA:3.40.1190.10 99 324 6.9E-69 T 09-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 TK78_RS27090 a4f9a911196da244fdc059e7b059716a 475 SUPERFAMILY SSF51984 5 99 4.19E-17 T 09-03-2017 TK78_RS08695 b14083e5537b3f3268ce553a2f15dc54 347 Hamap MF_01035 3-isopropylmalate dehydrogenase [leuB]. 5 345 59.906 T 09-03-2017 IPR023698 3-isopropylmalate dehydrogenase GO:0003862|GO:0009098|GO:0055114 KEGG: 00290+1.1.1.85|KEGG: 00660+1.1.1.85|MetaCyc: PWY-7396 TK78_RS08695 b14083e5537b3f3268ce553a2f15dc54 347 SMART SM01329 6 341 1.1E-170 T 09-03-2017 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 Reactome: R-HSA-71403 TK78_RS08695 b14083e5537b3f3268ce553a2f15dc54 347 ProSitePatterns PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 239 258 - T 09-03-2017 IPR019818 Isocitrate/isopropylmalate dehydrogenase, conserved site GO:0000287|GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-71403 TK78_RS08695 b14083e5537b3f3268ce553a2f15dc54 347 Pfam PF00180 Isocitrate/isopropylmalate dehydrogenase 7 334 1.2E-92 T 09-03-2017 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 Reactome: R-HSA-71403 TK78_RS08695 b14083e5537b3f3268ce553a2f15dc54 347 SUPERFAMILY SSF53659 5 342 2.88E-113 T 09-03-2017 TK78_RS08695 b14083e5537b3f3268ce553a2f15dc54 347 Gene3D G3DSA:3.40.718.10 6 339 7.2E-119 T 09-03-2017 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 Reactome: R-HSA-71403 TK78_RS19990 3dbc255f889f515a6ee102c0af20eecf 259 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 95 252 1.4E-29 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS19990 3dbc255f889f515a6ee102c0af20eecf 259 Pfam PF08281 Sigma-70, region 4 199 250 1.2E-13 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS19990 3dbc255f889f515a6ee102c0af20eecf 259 SUPERFAMILY SSF88659 182 254 1.16E-13 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS19990 3dbc255f889f515a6ee102c0af20eecf 259 Gene3D G3DSA:1.10.10.10 193 255 5.8E-15 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS19990 3dbc255f889f515a6ee102c0af20eecf 259 Gene3D G3DSA:1.10.1740.10 83 192 1.3E-28 T 09-03-2017 TK78_RS19990 3dbc255f889f515a6ee102c0af20eecf 259 SUPERFAMILY SSF88946 78 186 9.61E-27 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS19990 3dbc255f889f515a6ee102c0af20eecf 259 TIGRFAM TIGR02952 Sig70_famx2: RNA polymerase sigma-70 factor, TIGR02952 family 85 254 4.0E-78 T 09-03-2017 IPR014298 RNA polymerase sigma-X type TK78_RS19990 3dbc255f889f515a6ee102c0af20eecf 259 Pfam PF04542 Sigma-70 region 2 100 167 7.6E-18 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS26790 e59e8cad2726e8adc13beffe69454f45 350 SUPERFAMILY SSF50022 167 348 2.23E-27 T 09-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 TK78_RS26790 e59e8cad2726e8adc13beffe69454f45 350 PRINTS PR00162 Rieske 2Fe-2S subunit signature 271 282 7.6E-5 T 09-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 TK78_RS26790 e59e8cad2726e8adc13beffe69454f45 350 PRINTS PR00162 Rieske 2Fe-2S subunit signature 293 305 7.6E-5 T 09-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 TK78_RS26790 e59e8cad2726e8adc13beffe69454f45 350 PRINTS PR00162 Rieske 2Fe-2S subunit signature 307 319 7.6E-5 T 09-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 TK78_RS26790 e59e8cad2726e8adc13beffe69454f45 350 Gene3D G3DSA:2.102.10.10 206 349 2.9E-35 T 09-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 TK78_RS26790 e59e8cad2726e8adc13beffe69454f45 350 Pfam PF00355 Rieske [2Fe-2S] domain 236 321 1.0E-10 T 09-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 TK78_RS09970 9560acfd7f9a4ff8885c08c26b54f8c9 160 ProSitePatterns PS01117 MarR-type HTH domain signature. 83 117 - T 09-03-2017 IPR023187 Transcriptional regulator MarR-type, conserved site TK78_RS09970 9560acfd7f9a4ff8885c08c26b54f8c9 160 Pfam PF12802 MarR family 51 108 4.0E-11 T 09-03-2017 TK78_RS09970 9560acfd7f9a4ff8885c08c26b54f8c9 160 SUPERFAMILY SSF46785 25 158 1.83E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS09970 9560acfd7f9a4ff8885c08c26b54f8c9 160 SMART SM00347 44 144 9.2E-18 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS09970 9560acfd7f9a4ff8885c08c26b54f8c9 160 Gene3D G3DSA:1.10.10.10 21 158 8.7E-28 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS28895 a2f12c0c36c055aad38947c6b2f322f8 296 Gene3D G3DSA:3.40.50.1820 38 293 2.2E-81 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS28895 a2f12c0c36c055aad38947c6b2f322f8 296 Pfam PF01674 Lipase (class 2) 61 263 1.2E-12 T 09-03-2017 IPR002918 Lipase EstA/Esterase EstB GO:0016787 KEGG: 00561+3.1.1.3|MetaCyc: PWY-6857 TK78_RS28895 a2f12c0c36c055aad38947c6b2f322f8 296 SUPERFAMILY SSF53474 57 240 8.25E-30 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS12855 047931b183d01934d0832a468b2ec57b 416 Pfam PF12697 Alpha/beta hydrolase family 126 387 4.2E-21 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS12855 047931b183d01934d0832a468b2ec57b 416 SUPERFAMILY SSF53474 115 393 2.28E-49 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS12855 047931b183d01934d0832a468b2ec57b 416 Gene3D G3DSA:3.40.50.1820 113 393 9.6E-57 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS26290 a14d9588ef604365c3c1e0a9571bb098 294 SMART SM00422 11 80 3.6E-16 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS26290 a14d9588ef604365c3c1e0a9571bb098 294 SUPERFAMILY SSF46955 12 118 1.79E-20 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS26290 a14d9588ef604365c3c1e0a9571bb098 294 Pfam PF00376 MerR family regulatory protein 12 49 7.8E-11 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS26290 a14d9588ef604365c3c1e0a9571bb098 294 Gene3D G3DSA:1.10.1660.10 12 119 4.9E-24 T 09-03-2017 TK78_RS03625 c644765766cf0cd745d35161cc5e5301 546 SMART SM00387 262 376 0.0035 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS03625 c644765766cf0cd745d35161cc5e5301 546 SUPERFAMILY SSF55874 255 375 7.86E-15 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS03625 c644765766cf0cd745d35161cc5e5301 546 Gene3D G3DSA:3.30.565.10 242 376 7.2E-13 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS21240 5cc11e2ee558206d5a6e765ae441e951 244 Gene3D G3DSA:1.10.10.10 156 210 4.1E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS21240 5cc11e2ee558206d5a6e765ae441e951 244 SUPERFAMILY SSF46894 147 211 2.01E-16 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS21240 5cc11e2ee558206d5a6e765ae441e951 244 SMART SM00448 6 118 9.1E-29 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS21240 5cc11e2ee558206d5a6e765ae441e951 244 SUPERFAMILY SSF52172 6 130 6.26E-32 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS21240 5cc11e2ee558206d5a6e765ae441e951 244 Pfam PF00196 Bacterial regulatory proteins, luxR family 155 209 2.6E-15 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS21240 5cc11e2ee558206d5a6e765ae441e951 244 Gene3D G3DSA:3.40.50.2300 6 155 5.0E-35 T 09-03-2017 TK78_RS21240 5cc11e2ee558206d5a6e765ae441e951 244 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 169 185 7.7E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS21240 5cc11e2ee558206d5a6e765ae441e951 244 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 155 169 7.7E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS21240 5cc11e2ee558206d5a6e765ae441e951 244 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 185 197 7.7E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS21240 5cc11e2ee558206d5a6e765ae441e951 244 SMART SM00421 152 209 1.2E-17 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS21240 5cc11e2ee558206d5a6e765ae441e951 244 Pfam PF00072 Response regulator receiver domain 8 115 2.1E-25 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS10895 144a25f7f1891cb8987c27ba5a24a8de 195 ProSitePatterns PS00101 Hexapeptide-repeat containing-transferases signature. 144 172 - T 09-03-2017 IPR018357 Hexapeptide transferase, conserved site GO:0016740 Reactome: R-HSA-446205 TK78_RS10895 144a25f7f1891cb8987c27ba5a24a8de 195 SMART SM01266 10 64 1.5E-20 T 09-03-2017 IPR024688 Maltose/galactoside acetyltransferase GO:0016407 TK78_RS10895 144a25f7f1891cb8987c27ba5a24a8de 195 Gene3D G3DSA:2.160.10.10 9 189 6.5E-57 T 09-03-2017 TK78_RS10895 144a25f7f1891cb8987c27ba5a24a8de 195 SUPERFAMILY SSF51161 10 189 7.21E-53 T 09-03-2017 IPR011004 Trimeric LpxA-like TK78_RS10895 144a25f7f1891cb8987c27ba5a24a8de 195 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 136 170 1.8E-9 T 09-03-2017 IPR001451 Hexapeptide repeat TK78_RS10895 144a25f7f1891cb8987c27ba5a24a8de 195 Pfam PF12464 Maltose acetyltransferase 13 63 1.6E-15 T 09-03-2017 IPR024688 Maltose/galactoside acetyltransferase GO:0016407 TK78_RS09070 4df99536638987eca71e0fef196c61fe 452 SMART SM00530 24 80 3.3E-8 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS09070 4df99536638987eca71e0fef196c61fe 452 Pfam PF13560 Helix-turn-helix domain 20 79 7.6E-10 T 09-03-2017 TK78_RS09070 4df99536638987eca71e0fef196c61fe 452 Pfam PF00931 NB-ARC domain 114 321 2.9E-13 T 09-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 TK78_RS09070 4df99536638987eca71e0fef196c61fe 452 PRINTS PR00364 Disease resistance protein signature 134 149 1.3E-7 T 09-03-2017 TK78_RS09070 4df99536638987eca71e0fef196c61fe 452 PRINTS PR00364 Disease resistance protein signature 208 222 1.3E-7 T 09-03-2017 TK78_RS09070 4df99536638987eca71e0fef196c61fe 452 PRINTS PR00364 Disease resistance protein signature 293 307 1.3E-7 T 09-03-2017 TK78_RS09070 4df99536638987eca71e0fef196c61fe 452 SUPERFAMILY SSF47413 19 78 3.22E-10 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS09070 4df99536638987eca71e0fef196c61fe 452 Gene3D G3DSA:3.40.50.300 110 229 5.9E-6 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09070 4df99536638987eca71e0fef196c61fe 452 SUPERFAMILY SSF52540 107 326 1.22E-23 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09070 4df99536638987eca71e0fef196c61fe 452 Gene3D G3DSA:1.10.260.40 16 77 1.6E-13 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS02195 9431005fdb5eeb591e61d47473643463 248 Pfam PF13085 2Fe-2S iron-sulfur cluster binding domain 4 119 4.4E-24 T 09-03-2017 IPR025192 Succinate dehydogenase/fumarate reductase N-terminal GO:0009055|GO:0051536 KEGG: 00020+1.3.5.1|KEGG: 00190+1.3.5.1|KEGG: 00650+1.3.5.1|KEGG: 00720+1.3.5.1|MetaCyc: PWY-3781|MetaCyc: PWY-4302|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7279|Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS02195 9431005fdb5eeb591e61d47473643463 248 SUPERFAMILY SSF54292 1 115 4.18E-20 T 09-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 TK78_RS02195 9431005fdb5eeb591e61d47473643463 248 Gene3D G3DSA:3.10.20.30 1 109 5.6E-29 T 09-03-2017 IPR012675 Beta-grasp domain TK78_RS02195 9431005fdb5eeb591e61d47473643463 248 SUPERFAMILY SSF46548 119 241 1.48E-24 T 09-03-2017 IPR009051 Alpha-helical ferredoxin GO:0051536 TK78_RS02195 9431005fdb5eeb591e61d47473643463 248 Pfam PF13183 4Fe-4S dicluster domain 157 227 1.0E-10 T 09-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TK78_RS02195 9431005fdb5eeb591e61d47473643463 248 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 58 66 - T 09-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 TK78_RS02195 9431005fdb5eeb591e61d47473643463 248 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 158 169 - T 09-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TK78_RS02195 9431005fdb5eeb591e61d47473643463 248 Gene3D G3DSA:1.10.1060.10 110 242 1.8E-20 T 09-03-2017 TK78_RS19215 33fd445cb5f71cbcafda1f7d0916e21a 347 Gene3D G3DSA:3.40.640.10 1 248 4.3E-74 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS19215 33fd445cb5f71cbcafda1f7d0916e21a 347 SUPERFAMILY SSF53383 1 344 4.08E-105 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS19215 33fd445cb5f71cbcafda1f7d0916e21a 347 Pfam PF01212 Beta-eliminating lyase 4 287 3.6E-84 T 09-03-2017 IPR001597 Aromatic amino acid beta-eliminating lyase/threonine aldolase GO:0006520|GO:0016829 Reactome: R-HSA-6783984 TK78_RS19215 33fd445cb5f71cbcafda1f7d0916e21a 347 Gene3D G3DSA:3.90.1150.10 250 344 1.9E-25 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS19215 33fd445cb5f71cbcafda1f7d0916e21a 347 PIRSF PIRSF017617 1 347 1.5E-120 T 09-03-2017 IPR023603 Threonine aldolase TK78_RS33775 f8218aed9d41e9a19f69ed839ce49362 907 SUPERFAMILY SSF48239 673 793 1.69E-19 T 09-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid TK78_RS33775 f8218aed9d41e9a19f69ed839ce49362 907 SUPERFAMILY SSF48239 363 477 1.28E-14 T 09-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid TK78_RS33775 f8218aed9d41e9a19f69ed839ce49362 907 Gene3D G3DSA:1.50.10.20 364 468 1.7E-32 T 09-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid TK78_RS33775 f8218aed9d41e9a19f69ed839ce49362 907 Gene3D G3DSA:1.50.10.20 659 793 1.7E-32 T 09-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid TK78_RS33775 f8218aed9d41e9a19f69ed839ce49362 907 Pfam PF00432 Prenyltransferase and squalene oxidase repeat 438 473 0.042 T 09-03-2017 IPR001330 PFTB repeat GO:0003824 TK78_RS33775 f8218aed9d41e9a19f69ed839ce49362 907 Pfam PF00432 Prenyltransferase and squalene oxidase repeat 775 792 0.062 T 09-03-2017 IPR001330 PFTB repeat GO:0003824 TK78_RS33775 f8218aed9d41e9a19f69ed839ce49362 907 Pfam PF00432 Prenyltransferase and squalene oxidase repeat 728 753 0.11 T 09-03-2017 IPR001330 PFTB repeat GO:0003824 TK78_RS27875 a3a6a82b97d1b7884b20a58111314ebb 403 Gene3D G3DSA:3.40.50.1270 183 391 3.7E-78 T 09-03-2017 IPR015901 Phosphoglycerate kinase, C-terminal GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27875 a3a6a82b97d1b7884b20a58111314ebb 403 ProSitePatterns PS00111 Phosphoglycerate kinase signature. 16 26 - T 09-03-2017 IPR015911 Phosphoglycerate kinase, conserved site GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27875 a3a6a82b97d1b7884b20a58111314ebb 403 PIRSF PIRSF000724 1 403 2.3E-130 T 09-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27875 a3a6a82b97d1b7884b20a58111314ebb 403 SUPERFAMILY SSF53748 5 403 2.24E-140 T 09-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27875 a3a6a82b97d1b7884b20a58111314ebb 403 Hamap MF_00145 Phosphoglycerate kinase [pgk]. 3 403 40.513 T 09-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27875 a3a6a82b97d1b7884b20a58111314ebb 403 PRINTS PR00477 Phosphoglycerate kinase family signature 142 164 6.3E-79 T 09-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27875 a3a6a82b97d1b7884b20a58111314ebb 403 PRINTS PR00477 Phosphoglycerate kinase family signature 32 54 6.3E-79 T 09-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27875 a3a6a82b97d1b7884b20a58111314ebb 403 PRINTS PR00477 Phosphoglycerate kinase family signature 172 194 6.3E-79 T 09-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27875 a3a6a82b97d1b7884b20a58111314ebb 403 PRINTS PR00477 Phosphoglycerate kinase family signature 195 214 6.3E-79 T 09-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27875 a3a6a82b97d1b7884b20a58111314ebb 403 PRINTS PR00477 Phosphoglycerate kinase family signature 11 27 6.3E-79 T 09-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27875 a3a6a82b97d1b7884b20a58111314ebb 403 PRINTS PR00477 Phosphoglycerate kinase family signature 110 125 6.3E-79 T 09-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27875 a3a6a82b97d1b7884b20a58111314ebb 403 PRINTS PR00477 Phosphoglycerate kinase family signature 379 396 6.3E-79 T 09-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27875 a3a6a82b97d1b7884b20a58111314ebb 403 PRINTS PR00477 Phosphoglycerate kinase family signature 322 347 6.3E-79 T 09-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27875 a3a6a82b97d1b7884b20a58111314ebb 403 PRINTS PR00477 Phosphoglycerate kinase family signature 355 366 6.3E-79 T 09-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27875 a3a6a82b97d1b7884b20a58111314ebb 403 Gene3D G3DSA:3.40.50.1260 1 176 1.2E-63 T 09-03-2017 IPR015824 Phosphoglycerate kinase, N-terminal GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27875 a3a6a82b97d1b7884b20a58111314ebb 403 Pfam PF00162 Phosphoglycerate kinase 12 393 2.0E-144 T 09-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS00480 ac88dd42c1d32b27da0c29da241d36b8 275 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 87 264 7.2E-19 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS00480 ac88dd42c1d32b27da0c29da241d36b8 275 SUPERFAMILY SSF161098 5 274 4.45E-60 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS00480 ac88dd42c1d32b27da0c29da241d36b8 275 Gene3D G3DSA:1.10.3720.10 5 262 1.7E-54 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS03845 fc47699a997da127d5ae967cc85386c0 338 SUPERFAMILY SSF47413 1 59 2.97E-19 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS03845 fc47699a997da127d5ae967cc85386c0 338 Gene3D G3DSA:1.10.260.40 2 57 7.9E-27 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS03845 fc47699a997da127d5ae967cc85386c0 338 Pfam PF00356 Bacterial regulatory proteins, lacI family 3 48 1.9E-20 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS03845 fc47699a997da127d5ae967cc85386c0 338 SMART SM00354 1 71 1.5E-36 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS03845 fc47699a997da127d5ae967cc85386c0 338 Pfam PF13377 Periplasmic binding protein-like domain 168 327 6.7E-36 T 09-03-2017 TK78_RS03845 fc47699a997da127d5ae967cc85386c0 338 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 13 23 4.7E-6 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS03845 fc47699a997da127d5ae967cc85386c0 338 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 3 13 4.7E-6 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS03845 fc47699a997da127d5ae967cc85386c0 338 ProSitePatterns PS00356 LacI-type HTH domain signature. 4 22 - T 09-03-2017 TK78_RS03845 fc47699a997da127d5ae967cc85386c0 338 Gene3D G3DSA:3.40.50.2300 166 328 3.1E-54 T 09-03-2017 TK78_RS03845 fc47699a997da127d5ae967cc85386c0 338 Gene3D G3DSA:3.40.50.2300 58 165 7.4E-34 T 09-03-2017 TK78_RS03845 fc47699a997da127d5ae967cc85386c0 338 SUPERFAMILY SSF53822 60 329 8.16E-74 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS30450 4e270753ef58d7a84cd378eb07c319fc 786 SMART SM00495 738 783 2.1E-9 T 09-03-2017 IPR003610 Carbohydrate-binding module family 5/12 GO:0004553|GO:0005576|GO:0005975|GO:0030246 TK78_RS30450 4e270753ef58d7a84cd378eb07c319fc 786 ProSitePatterns PS01095 Chitinases family 18 active site. 224 232 - T 09-03-2017 IPR001579 Glycoside hydrolase, chitinase active site GO:0004553|GO:0005975 KEGG: 00520+3.2.1.14|MetaCyc: PWY-6902 TK78_RS30450 4e270753ef58d7a84cd378eb07c319fc 786 SUPERFAMILY SSF51055 735 786 1.28E-12 T 09-03-2017 IPR003610 Carbohydrate-binding module family 5/12 GO:0004553|GO:0005576|GO:0005975|GO:0030246 TK78_RS30450 4e270753ef58d7a84cd378eb07c319fc 786 Pfam PF02839 Carbohydrate binding domain 738 780 7.7E-9 T 09-03-2017 IPR003610 Carbohydrate-binding module family 5/12 GO:0004553|GO:0005576|GO:0005975|GO:0030246 TK78_RS30450 4e270753ef58d7a84cd378eb07c319fc 786 Gene3D G3DSA:2.10.10.20 736 783 8.3E-17 T 09-03-2017 IPR003610 Carbohydrate-binding module family 5/12 GO:0004553|GO:0005576|GO:0005975|GO:0030246 TK78_RS30450 4e270753ef58d7a84cd378eb07c319fc 786 Gene3D G3DSA:3.20.20.80 502 535 6.9E-91 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS30450 4e270753ef58d7a84cd378eb07c319fc 786 Gene3D G3DSA:3.20.20.80 66 383 6.9E-91 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS30450 4e270753ef58d7a84cd378eb07c319fc 786 SUPERFAMILY SSF54556 382 495 8.24E-14 T 09-03-2017 IPR029070 Chitinase insertion domain TK78_RS30450 4e270753ef58d7a84cd378eb07c319fc 786 SUPERFAMILY SSF51445 66 382 8.43E-78 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS30450 4e270753ef58d7a84cd378eb07c319fc 786 SUPERFAMILY SSF51445 497 529 8.43E-78 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS30450 4e270753ef58d7a84cd378eb07c319fc 786 SMART SM00636 72 525 5.8E-122 T 09-03-2017 IPR011583 Chitinase II GO:0004568|GO:0006032 TK78_RS30450 4e270753ef58d7a84cd378eb07c319fc 786 Pfam PF06483 Chitinase C 534 706 1.4E-79 T 09-03-2017 IPR009470 Chitinase, C-terminal KEGG: 00520+3.2.1.14|MetaCyc: PWY-6902 TK78_RS30450 4e270753ef58d7a84cd378eb07c319fc 786 Gene3D G3DSA:3.10.50.10 472 496 5.5E-18 T 09-03-2017 IPR029070 Chitinase insertion domain TK78_RS30450 4e270753ef58d7a84cd378eb07c319fc 786 Gene3D G3DSA:3.10.50.10 384 432 5.5E-18 T 09-03-2017 IPR029070 Chitinase insertion domain TK78_RS30450 4e270753ef58d7a84cd378eb07c319fc 786 Pfam PF00704 Glycosyl hydrolases family 18 73 525 1.6E-82 T 09-03-2017 IPR001223 Glycoside hydrolase family 18, catalytic domain GO:0004553|GO:0005975 TK78_RS16960 81b73817bbba1caa43c78422da2c967e 161 SUPERFAMILY SSF55874 31 147 1.7E-13 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS16960 81b73817bbba1caa43c78422da2c967e 161 Pfam PF13581 Histidine kinase-like ATPase domain 12 146 2.7E-21 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS16960 81b73817bbba1caa43c78422da2c967e 161 Gene3D G3DSA:3.30.565.10 33 149 1.3E-14 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS13705 d74336e02430d7cf982fd3324382d325 230 ProSitePatterns PS01184 ubiE/COQ5 methyltransferase family signature 2. 137 151 - T 09-03-2017 IPR023576 UbiE/COQ5 methyltransferase, conserved site GO:0008168 KEGG: 00130+2.1.1.163|KEGG: 00564+2.1.1.16|MetaCyc: PWY-5839|MetaCyc: PWY-5844|MetaCyc: PWY-5849|MetaCyc: PWY-5890|MetaCyc: PWY-5891|MetaCyc: PWY-5892|MetaCyc: PWY-5895 TK78_RS13705 d74336e02430d7cf982fd3324382d325 230 SUPERFAMILY SSF53335 4 225 2.66E-44 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS13705 d74336e02430d7cf982fd3324382d325 230 Gene3D G3DSA:3.40.50.150 12 226 7.4E-45 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS13705 d74336e02430d7cf982fd3324382d325 230 TIGRFAM TIGR01934 MenG_MenH_UbiE: ubiquinone/menaquinone biosynthesis methyltransferase 13 228 5.0E-71 T 09-03-2017 IPR004033 UbiE/COQ5 methyltransferase GO:0008168 KEGG: 00130+2.1.1.163|KEGG: 00564+2.1.1.16|MetaCyc: PWY-5839|MetaCyc: PWY-5844|MetaCyc: PWY-5849|MetaCyc: PWY-5890|MetaCyc: PWY-5891|MetaCyc: PWY-5892|MetaCyc: PWY-5895|Reactome: R-HSA-2142789 TK78_RS13705 d74336e02430d7cf982fd3324382d325 230 Hamap MF_01813 Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE [ubiE]. 4 229 33.979 T 09-03-2017 IPR004033 UbiE/COQ5 methyltransferase GO:0008168 KEGG: 00130+2.1.1.163|KEGG: 00564+2.1.1.16|MetaCyc: PWY-5839|MetaCyc: PWY-5844|MetaCyc: PWY-5849|MetaCyc: PWY-5890|MetaCyc: PWY-5891|MetaCyc: PWY-5892|MetaCyc: PWY-5895|Reactome: R-HSA-2142789 TK78_RS13705 d74336e02430d7cf982fd3324382d325 230 Pfam PF01209 ubiE/COQ5 methyltransferase family 11 228 4.1E-63 T 09-03-2017 IPR004033 UbiE/COQ5 methyltransferase GO:0008168 KEGG: 00130+2.1.1.163|KEGG: 00564+2.1.1.16|MetaCyc: PWY-5839|MetaCyc: PWY-5844|MetaCyc: PWY-5849|MetaCyc: PWY-5890|MetaCyc: PWY-5891|MetaCyc: PWY-5892|MetaCyc: PWY-5895|Reactome: R-HSA-2142789 TK78_RS30275 8b88fc51bae16ae3121e069bbb23cc25 368 Gene3D G3DSA:3.90.230.10 138 365 1.8E-54 T 09-03-2017 IPR000994 Peptidase M24, structural domain TK78_RS30275 8b88fc51bae16ae3121e069bbb23cc25 368 Pfam PF00557 Metallopeptidase family M24 146 348 1.8E-42 T 09-03-2017 IPR000994 Peptidase M24, structural domain TK78_RS30275 8b88fc51bae16ae3121e069bbb23cc25 368 SUPERFAMILY SSF53092 8 137 2.44E-13 T 09-03-2017 IPR028980 Creatinase/Aminopeptidase P, N-terminal TK78_RS30275 8b88fc51bae16ae3121e069bbb23cc25 368 SUPERFAMILY SSF55920 137 366 4.84E-55 T 09-03-2017 IPR000994 Peptidase M24, structural domain TK78_RS30275 8b88fc51bae16ae3121e069bbb23cc25 368 Pfam PF01321 Creatinase/Prolidase N-terminal domain 8 138 2.8E-8 T 09-03-2017 IPR000587 Creatinase, N-terminal GO:0016787 TK78_RS30275 8b88fc51bae16ae3121e069bbb23cc25 368 Gene3D G3DSA:3.40.350.10 8 136 3.1E-8 T 09-03-2017 IPR029149 Creatinase/Aminopeptidase P/Spt16, N-terminal TK78_RS26145 508d3c53d1ecfd63b464c2a1e4261397 366 Gene3D G3DSA:3.40.50.1980 101 214 3.9E-19 T 09-03-2017 TK78_RS26145 508d3c53d1ecfd63b464c2a1e4261397 366 Pfam PF01497 Periplasmic binding protein 103 336 7.6E-29 T 09-03-2017 IPR002491 ABC transporter periplasmic binding domain GO:0005488 TK78_RS26145 508d3c53d1ecfd63b464c2a1e4261397 366 Gene3D G3DSA:3.40.50.1980 215 359 6.5E-16 T 09-03-2017 TK78_RS26145 508d3c53d1ecfd63b464c2a1e4261397 366 SUPERFAMILY SSF53807 90 359 3.07E-42 T 09-03-2017 TK78_RS34280 21246bc7940265ff3a59a893e00fbdfc 90 ProSitePatterns PS00369 PTS HPR domain histidine phosphorylation site signature. 13 20 - T 09-03-2017 IPR001020 Phosphotransferase system, HPr histidine phosphorylation site TK78_RS34280 21246bc7940265ff3a59a893e00fbdfc 90 PRINTS PR00107 Phosphocarrier protein signature 39 54 1.7E-9 T 09-03-2017 IPR000032 Phosphocarrier protein HPr-like TK78_RS34280 21246bc7940265ff3a59a893e00fbdfc 90 PRINTS PR00107 Phosphocarrier protein signature 13 29 1.7E-9 T 09-03-2017 IPR000032 Phosphocarrier protein HPr-like TK78_RS34280 21246bc7940265ff3a59a893e00fbdfc 90 PRINTS PR00107 Phosphocarrier protein signature 54 71 1.7E-9 T 09-03-2017 IPR000032 Phosphocarrier protein HPr-like TK78_RS34280 21246bc7940265ff3a59a893e00fbdfc 90 TIGRFAM TIGR01003 PTS_HPr_family: phosphocarrier, HPr family 1 82 8.3E-26 T 09-03-2017 IPR000032 Phosphocarrier protein HPr-like TK78_RS34280 21246bc7940265ff3a59a893e00fbdfc 90 Gene3D G3DSA:3.30.1340.10 1 85 8.2E-26 T 09-03-2017 IPR000032 Phosphocarrier protein HPr-like TK78_RS34280 21246bc7940265ff3a59a893e00fbdfc 90 Pfam PF00381 PTS HPr component phosphorylation site 3 83 3.0E-25 T 09-03-2017 IPR000032 Phosphocarrier protein HPr-like TK78_RS34280 21246bc7940265ff3a59a893e00fbdfc 90 SUPERFAMILY SSF55594 1 87 1.23E-21 T 09-03-2017 IPR000032 Phosphocarrier protein HPr-like TK78_RS07675 cd192df71e603c4dcb20221b1392a1e4 737 SUPERFAMILY SSF54791 576 688 1.6E-19 T 09-03-2017 IPR004088 K Homology domain, type 1 GO:0003723 TK78_RS07675 cd192df71e603c4dcb20221b1392a1e4 737 Gene3D G3DSA:3.30.230.70 336 570 4.2E-80 T 09-03-2017 IPR027408 PNPase/RNase PH domain Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 TK78_RS07675 cd192df71e603c4dcb20221b1392a1e4 737 Gene3D G3DSA:3.30.230.70 8 249 9.0E-83 T 09-03-2017 IPR027408 PNPase/RNase PH domain Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 TK78_RS07675 cd192df71e603c4dcb20221b1392a1e4 737 Gene3D G3DSA:1.10.10.400 263 335 1.2E-23 T 09-03-2017 IPR015848 Polyribonucleotide nucleotidyltransferase, RNA-binding domain GO:0000175|GO:0003723|GO:0006396 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 TK78_RS07675 cd192df71e603c4dcb20221b1392a1e4 737 SMART SM00322 579 644 5.9E-13 T 09-03-2017 IPR004087 K Homology domain GO:0003676 TK78_RS07675 cd192df71e603c4dcb20221b1392a1e4 737 SUPERFAMILY SSF55666 152 260 1.03E-28 T 09-03-2017 IPR015847 Exoribonuclease, phosphorolytic domain 2 Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 TK78_RS07675 cd192df71e603c4dcb20221b1392a1e4 737 Hamap MF_01595 Polyribonucleotide nucleotidyltransferase [pnp]. 9 725 26.67 T 09-03-2017 IPR012162 Polyribonucleotide nucleotidyltransferase GO:0003723|GO:0004654|GO:0006402 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 TK78_RS07675 cd192df71e603c4dcb20221b1392a1e4 737 SUPERFAMILY SSF54211 6 151 5.57E-46 T 09-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold TK78_RS07675 cd192df71e603c4dcb20221b1392a1e4 737 SMART SM00316 649 723 3.5E-17 T 09-03-2017 IPR022967 RNA-binding domain, S1 TK78_RS07675 cd192df71e603c4dcb20221b1392a1e4 737 Gene3D G3DSA:3.30.1370.10 579 652 8.5E-24 T 09-03-2017 IPR004088 K Homology domain, type 1 GO:0003723 TK78_RS07675 cd192df71e603c4dcb20221b1392a1e4 737 TIGRFAM TIGR02696 pppGpp_PNP: guanosine pentaphosphate synthetase I/polyribonucleotide nucleotidyltransferase 5 722 0.0 T 09-03-2017 IPR014069 Guanosine pentaphosphate synthetase I/polyribonucleotide nucleotidyltransferase GO:0004654|GO:0005737|GO:0006402 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 TK78_RS07675 cd192df71e603c4dcb20221b1392a1e4 737 Pfam PF03726 Polyribonucleotide nucleotidyltransferase, RNA binding domain 267 343 1.3E-17 T 09-03-2017 IPR015848 Polyribonucleotide nucleotidyltransferase, RNA-binding domain GO:0000175|GO:0003723|GO:0006396 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 TK78_RS07675 cd192df71e603c4dcb20221b1392a1e4 737 Pfam PF00575 S1 RNA binding domain 648 718 1.4E-11 T 09-03-2017 IPR003029 S1 domain GO:0003676 TK78_RS07675 cd192df71e603c4dcb20221b1392a1e4 737 Pfam PF01138 3' exoribonuclease family, domain 1 348 480 1.8E-13 T 09-03-2017 IPR001247 Exoribonuclease, phosphorolytic domain 1 Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 TK78_RS07675 cd192df71e603c4dcb20221b1392a1e4 737 Pfam PF01138 3' exoribonuclease family, domain 1 20 151 7.1E-18 T 09-03-2017 IPR001247 Exoribonuclease, phosphorolytic domain 1 Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 TK78_RS07675 cd192df71e603c4dcb20221b1392a1e4 737 SUPERFAMILY SSF46915 264 344 6.02E-17 T 09-03-2017 IPR015848 Polyribonucleotide nucleotidyltransferase, RNA-binding domain GO:0000175|GO:0003723|GO:0006396 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 TK78_RS07675 cd192df71e603c4dcb20221b1392a1e4 737 PIRSF PIRSF005499 7 737 3.3E-281 T 09-03-2017 IPR012162 Polyribonucleotide nucleotidyltransferase GO:0003723|GO:0004654|GO:0006402 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 TK78_RS07675 cd192df71e603c4dcb20221b1392a1e4 737 Gene3D G3DSA:2.40.50.140 653 720 9.3E-17 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS07675 cd192df71e603c4dcb20221b1392a1e4 737 SUPERFAMILY SSF54211 321 492 4.45E-41 T 09-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold TK78_RS07675 cd192df71e603c4dcb20221b1392a1e4 737 SUPERFAMILY SSF55666 474 573 1.23E-23 T 09-03-2017 IPR015847 Exoribonuclease, phosphorolytic domain 2 Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 TK78_RS07675 cd192df71e603c4dcb20221b1392a1e4 737 Pfam PF00013 KH domain 583 639 8.4E-11 T 09-03-2017 IPR004088 K Homology domain, type 1 GO:0003723 TK78_RS07675 cd192df71e603c4dcb20221b1392a1e4 737 TIGRFAM TIGR03591 polynuc_phos: polyribonucleotide nucleotidyltransferase 17 720 1.2E-258 T 09-03-2017 IPR012162 Polyribonucleotide nucleotidyltransferase GO:0003723|GO:0004654|GO:0006402 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 TK78_RS04350 8d60071f22ff2531e4b311084282bf9a 262 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 186 203 3.4E-35 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04350 8d60071f22ff2531e4b311084282bf9a 262 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 223 243 3.4E-35 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04350 8d60071f22ff2531e4b311084282bf9a 262 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 91 102 3.4E-35 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04350 8d60071f22ff2531e4b311084282bf9a 262 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 17 34 3.4E-35 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04350 8d60071f22ff2531e4b311084282bf9a 262 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 139 155 3.4E-35 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04350 8d60071f22ff2531e4b311084282bf9a 262 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 165 184 3.4E-35 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04350 8d60071f22ff2531e4b311084282bf9a 262 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 152 180 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS04350 8d60071f22ff2531e4b311084282bf9a 262 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 165 184 4.0E-7 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04350 8d60071f22ff2531e4b311084282bf9a 262 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 91 102 4.0E-7 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04350 8d60071f22ff2531e4b311084282bf9a 262 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 22 260 2.7E-55 T 09-03-2017 TK78_RS04350 8d60071f22ff2531e4b311084282bf9a 262 SUPERFAMILY SSF51735 17 261 1.13E-67 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS04350 8d60071f22ff2531e4b311084282bf9a 262 Gene3D G3DSA:3.40.50.720 18 260 5.1E-73 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS29380 db694b215b228b45981cbb181748d388 453 PIRSF PIRSF018077 1 453 1.4E-182 T 09-03-2017 IPR004347 Pup ligase/deamidase GO:0010498|GO:0019941 TK78_RS29380 db694b215b228b45981cbb181748d388 453 Pfam PF03136 Pup-ligase protein 4 423 1.1E-157 T 09-03-2017 IPR004347 Pup ligase/deamidase GO:0010498|GO:0019941 TK78_RS29380 db694b215b228b45981cbb181748d388 453 TIGRFAM TIGR03686 pupylate_PafA: Pup--protein ligase 3 453 2.7E-232 T 09-03-2017 IPR022279 Pup--protein ligase GO:0010498|GO:0016879|GO:0019941 TK78_RS29380 db694b215b228b45981cbb181748d388 453 Hamap MF_02111 Pup--protein ligase [pafA]. 1 453 50.224 T 09-03-2017 IPR022279 Pup--protein ligase GO:0010498|GO:0016879|GO:0019941 TK78_RS10750 779811a2f169e074904abbb6787a1b1e 428 Gene3D G3DSA:1.25.60.10 163 276 1.8E-40 T 09-03-2017 TK78_RS10750 779811a2f169e074904abbb6787a1b1e 428 Pfam PF00571 CBS domain 350 405 5.6E-6 T 09-03-2017 IPR000644 CBS domain TK78_RS10750 779811a2f169e074904abbb6787a1b1e 428 Pfam PF00571 CBS domain 282 343 0.0021 T 09-03-2017 IPR000644 CBS domain TK78_RS10750 779811a2f169e074904abbb6787a1b1e 428 SUPERFAMILY SSF50346 11 88 5.18E-5 T 09-03-2017 IPR011033 PRC-barrel-like TK78_RS10750 779811a2f169e074904abbb6787a1b1e 428 SUPERFAMILY SSF54631 280 413 1.16E-24 T 09-03-2017 TK78_RS10750 779811a2f169e074904abbb6787a1b1e 428 Pfam PF03448 MgtE intracellular N domain 178 278 3.2E-27 T 09-03-2017 IPR006668 Magnesium transporter, MgtE intracellular domain TK78_RS10750 779811a2f169e074904abbb6787a1b1e 428 SMART SM00924 178 281 1.0E-35 T 09-03-2017 IPR006668 Magnesium transporter, MgtE intracellular domain TK78_RS10750 779811a2f169e074904abbb6787a1b1e 428 Gene3D G3DSA:3.10.580.10 279 405 1.8E-19 T 09-03-2017 TK78_RS10750 779811a2f169e074904abbb6787a1b1e 428 SUPERFAMILY SSF158791 166 278 3.4E-31 T 09-03-2017 TK78_RS27100 f9276f996e5e2b167871f20f8cefec09 362 TIGRFAM TIGR01133 murG: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase 2 351 1.5E-86 T 09-03-2017 IPR006009 N-acetylglucosaminyltransferase, MurG GO:0009252|GO:0050511 KEGG: 00052+2.4.1.22|KEGG: 00550+2.4.1.227|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TK78_RS27100 f9276f996e5e2b167871f20f8cefec09 362 Pfam PF03033 Glycosyltransferase family 28 N-terminal domain 3 142 5.4E-43 T 09-03-2017 IPR004276 Glycosyltransferase family 28, N-terminal domain GO:0005975|GO:0016758|GO:0030259 KEGG: 00052+2.4.1.22|KEGG: 00550+2.4.1.227|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TK78_RS27100 f9276f996e5e2b167871f20f8cefec09 362 Pfam PF04101 Glycosyltransferase family 28 C-terminal domain 188 348 4.9E-39 T 09-03-2017 IPR007235 Glycosyl transferase, family 28, C-terminal GO:0016758 KEGG: 00052+2.4.1.22|KEGG: 00550+2.4.1.227|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471|Reactome: R-HSA-446193|Reactome: R-HSA-5633231 TK78_RS27100 f9276f996e5e2b167871f20f8cefec09 362 Hamap MF_00033 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [murG]. 3 358 31.412 T 09-03-2017 IPR006009 N-acetylglucosaminyltransferase, MurG GO:0009252|GO:0050511 KEGG: 00052+2.4.1.22|KEGG: 00550+2.4.1.227|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TK78_RS27100 f9276f996e5e2b167871f20f8cefec09 362 SUPERFAMILY SSF53756 2 358 5.39E-98 T 09-03-2017 TK78_RS27100 f9276f996e5e2b167871f20f8cefec09 362 Gene3D G3DSA:3.40.50.2000 2 186 3.5E-60 T 09-03-2017 TK78_RS27100 f9276f996e5e2b167871f20f8cefec09 362 Gene3D G3DSA:3.40.50.2000 187 340 1.6E-18 T 09-03-2017 TK78_RS34000 6a22b2830de572ddbfe682b63c38ca44 164 ProSitePatterns PS01307 Flagellar motor protein motA family signature. 61 78 - T 09-03-2017 IPR000540 Flagellar motor protein MotA, conserved site TK78_RS34000 6a22b2830de572ddbfe682b63c38ca44 164 Pfam PF06897 Protein of unknown function (DUF1269) 61 159 6.1E-35 T 09-03-2017 IPR009200 Protein of unknown function DUF1269, membrane associated TK78_RS28815 5e78859f85766be23ffe5f3338924875 297 SUPERFAMILY SSF161098 72 283 2.75E-40 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS28815 5e78859f85766be23ffe5f3338924875 297 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 92 290 4.7E-22 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS28815 5e78859f85766be23ffe5f3338924875 297 TIGRFAM TIGR01726 HEQRo_perm_3TM: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family 72 135 1.0E-13 T 09-03-2017 IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain GO:0005215|GO:0006810|GO:0016021 TK78_RS28815 5e78859f85766be23ffe5f3338924875 297 Gene3D G3DSA:1.10.3720.10 67 291 2.8E-44 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS03805 dcdbfec1ee2ff694b363e1823d7ab271 400 Pfam PF02388 FemAB family 292 382 3.3E-13 T 09-03-2017 IPR003447 FemABX peptidyl transferase GO:0009252|GO:0016755 TK78_RS03805 dcdbfec1ee2ff694b363e1823d7ab271 400 Pfam PF02388 FemAB family 46 272 2.7E-23 T 09-03-2017 IPR003447 FemABX peptidyl transferase GO:0009252|GO:0016755 TK78_RS03805 dcdbfec1ee2ff694b363e1823d7ab271 400 SUPERFAMILY SSF55729 207 389 8.48E-33 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS03805 dcdbfec1ee2ff694b363e1823d7ab271 400 SUPERFAMILY SSF55729 26 138 5.83E-25 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS03805 dcdbfec1ee2ff694b363e1823d7ab271 400 SUPERFAMILY SSF55729 165 215 5.83E-25 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS03805 dcdbfec1ee2ff694b363e1823d7ab271 400 Gene3D G3DSA:3.40.630.30 24 206 2.2E-39 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS03805 dcdbfec1ee2ff694b363e1823d7ab271 400 Gene3D G3DSA:3.40.630.30 207 370 5.3E-46 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS06695 7a9dd46a89cd8fa7ca20e5d4fb07fe7a 386 Gene3D G3DSA:3.75.10.10 49 381 4.8E-119 T 09-03-2017 TK78_RS06695 7a9dd46a89cd8fa7ca20e5d4fb07fe7a 386 SUPERFAMILY SSF55909 50 381 4.1E-108 T 09-03-2017 TK78_RS06695 7a9dd46a89cd8fa7ca20e5d4fb07fe7a 386 Pfam PF04371 Porphyromonas-type peptidyl-arginine deiminase 54 381 1.1E-107 T 09-03-2017 IPR007466 Peptidyl-arginine deiminase, Porphyromonas-type GO:0004668|GO:0009446 KEGG: 00330+3.5.3.12|MetaCyc: PWY-43 TK78_RS03320 99c66b753b7279e15e57d6fe4c7a435d 404 ProSitePatterns PS00099 Thiolases active site. 385 398 - T 09-03-2017 IPR020610 Thiolase, active site GO:0008152|GO:0016747 TK78_RS03320 99c66b753b7279e15e57d6fe4c7a435d 404 Gene3D G3DSA:3.40.47.10 5 128 1.0E-55 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS03320 99c66b753b7279e15e57d6fe4c7a435d 404 Gene3D G3DSA:3.40.47.10 187 287 1.0E-55 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS03320 99c66b753b7279e15e57d6fe4c7a435d 404 SUPERFAMILY SSF53901 282 403 3.23E-44 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS03320 99c66b753b7279e15e57d6fe4c7a435d 404 SUPERFAMILY SSF53901 3 278 1.07E-62 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS03320 99c66b753b7279e15e57d6fe4c7a435d 404 TIGRFAM TIGR01930 AcCoA-C-Actrans: acetyl-CoA C-acyltransferase 7 402 4.6E-134 T 09-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 TK78_RS03320 99c66b753b7279e15e57d6fe4c7a435d 404 Pfam PF02803 Thiolase, C-terminal domain 282 403 2.3E-47 T 09-03-2017 IPR020617 Thiolase, C-terminal GO:0008152|GO:0016747 TK78_RS03320 99c66b753b7279e15e57d6fe4c7a435d 404 Gene3D G3DSA:3.40.47.10 288 403 5.6E-58 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS03320 99c66b753b7279e15e57d6fe4c7a435d 404 Gene3D G3DSA:3.40.47.10 148 186 5.6E-58 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS03320 99c66b753b7279e15e57d6fe4c7a435d 404 ProSitePatterns PS00737 Thiolases signature 2. 350 366 - T 09-03-2017 IPR020613 Thiolase, conserved site GO:0008152|GO:0016747 TK78_RS03320 99c66b753b7279e15e57d6fe4c7a435d 404 PIRSF PIRSF000429 2 404 2.4E-109 T 09-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 TK78_RS03320 99c66b753b7279e15e57d6fe4c7a435d 404 Pfam PF00108 Thiolase, N-terminal domain 7 230 5.1E-43 T 09-03-2017 IPR020616 Thiolase, N-terminal GO:0008152|GO:0016747 TK78_RS13765 ab46d674af24657631dd9a35707ddd68 274 SUPERFAMILY SSF46955 2 115 2.89E-23 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS13765 ab46d674af24657631dd9a35707ddd68 274 SMART SM00871 119 272 8.5E-16 T 09-03-2017 IPR010499 Bacterial transcription activator, effector binding TK78_RS13765 ab46d674af24657631dd9a35707ddd68 274 Gene3D G3DSA:3.20.80.10 120 272 2.3E-9 T 09-03-2017 IPR011256 Regulatory factor, effector binding domain TK78_RS13765 ab46d674af24657631dd9a35707ddd68 274 Pfam PF13411 MerR HTH family regulatory protein 2 71 1.3E-14 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS13765 ab46d674af24657631dd9a35707ddd68 274 Gene3D G3DSA:1.10.1660.10 58 112 2.9E-6 T 09-03-2017 TK78_RS13765 ab46d674af24657631dd9a35707ddd68 274 SMART SM00422 2 72 1.5E-18 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS13765 ab46d674af24657631dd9a35707ddd68 274 Pfam PF06445 GyrI-like small molecule binding domain 120 271 6.4E-16 T 09-03-2017 IPR029442 GyrI-like small molecule binding domain TK78_RS13765 ab46d674af24657631dd9a35707ddd68 274 Gene3D G3DSA:1.10.1660.10 1 57 5.5E-22 T 09-03-2017 TK78_RS13765 ab46d674af24657631dd9a35707ddd68 274 SUPERFAMILY SSF55136 120 273 4.36E-21 T 09-03-2017 IPR011256 Regulatory factor, effector binding domain TK78_RS13580 4ca8841c066f518bdcb806372480df86 399 Gene3D G3DSA:3.30.565.10 259 376 1.4E-4 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS13580 4ca8841c066f518bdcb806372480df86 399 SUPERFAMILY SSF55874 257 370 1.17E-10 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS13580 4ca8841c066f518bdcb806372480df86 399 Pfam PF07730 Histidine kinase 172 237 5.4E-15 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS19455 9ebc6d939bddf2bcbcc78bf4278f140b 385 SUPERFAMILY SSF51556 56 350 3.4E-93 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS19455 9ebc6d939bddf2bcbcc78bf4278f140b 385 Pfam PF01979 Amidohydrolase family 52 378 4.2E-29 T 09-03-2017 IPR006680 Amidohydrolase-related GO:0016787 TK78_RS19455 9ebc6d939bddf2bcbcc78bf4278f140b 385 TIGRFAM TIGR00221 nagA: N-acetylglucosamine-6-phosphate deacetylase 13 376 4.7E-83 T 09-03-2017 IPR003764 N-acetylglucosamine-6-phosphate deacetylase GO:0006044|GO:0008448 KEGG: 00052+3.5.1.25|KEGG: 00520+3.5.1.25|MetaCyc: PWY-6906|MetaCyc: PWY-7077|MetaCyc: PWY-7395|Reactome: R-HSA-446210 TK78_RS19455 9ebc6d939bddf2bcbcc78bf4278f140b 385 Gene3D G3DSA:2.30.40.10 358 366 4.1E-13 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS19455 9ebc6d939bddf2bcbcc78bf4278f140b 385 Gene3D G3DSA:2.30.40.10 6 57 4.1E-13 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS19455 9ebc6d939bddf2bcbcc78bf4278f140b 385 Gene3D G3DSA:2.30.40.10 335 357 7.6E-8 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS19455 9ebc6d939bddf2bcbcc78bf4278f140b 385 Gene3D G3DSA:3.20.20.140 58 334 2.8E-98 T 09-03-2017 TK78_RS19455 9ebc6d939bddf2bcbcc78bf4278f140b 385 PIRSF PIRSF038994 9 383 2.8E-112 T 09-03-2017 IPR003764 N-acetylglucosamine-6-phosphate deacetylase GO:0006044|GO:0008448 KEGG: 00052+3.5.1.25|KEGG: 00520+3.5.1.25|MetaCyc: PWY-6906|MetaCyc: PWY-7077|MetaCyc: PWY-7395|Reactome: R-HSA-446210 TK78_RS19455 9ebc6d939bddf2bcbcc78bf4278f140b 385 SUPERFAMILY SSF51338 6 56 7.16E-16 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS19455 9ebc6d939bddf2bcbcc78bf4278f140b 385 SUPERFAMILY SSF51338 350 368 7.16E-16 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS11400 ebc2e44b1cfa5ec7ff8590afb96e310e 333 SUPERFAMILY SSF46894 271 331 1.7E-8 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS11400 ebc2e44b1cfa5ec7ff8590afb96e310e 333 Gene3D G3DSA:1.10.10.10 275 331 3.0E-10 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS11400 ebc2e44b1cfa5ec7ff8590afb96e310e 333 SMART SM00421 268 325 0.004 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS11400 ebc2e44b1cfa5ec7ff8590afb96e310e 333 Pfam PF00196 Bacterial regulatory proteins, luxR family 275 321 3.3E-6 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS21785 02f6b60c1577efba83ce0e8e3f0b7c7a 494 SUPERFAMILY SSF103473 15 250 3.27E-23 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS21785 02f6b60c1577efba83ce0e8e3f0b7c7a 494 ProSitePatterns PS01023 PTR2 family proton/oligopeptide symporters signature 2. 154 166 - T 09-03-2017 IPR018456 PTR2 family proton/oligopeptide symporter, conserved site GO:0005215|GO:0006857|GO:0016020 Reactome: R-HSA-427975 TK78_RS21785 02f6b60c1577efba83ce0e8e3f0b7c7a 494 SUPERFAMILY SSF103473 223 483 7.46E-7 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS21785 02f6b60c1577efba83ce0e8e3f0b7c7a 494 Pfam PF00854 POT family 92 450 1.1E-61 T 09-03-2017 IPR000109 Proton-dependent oligopeptide transporter family GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-427975 TK78_RS21785 02f6b60c1577efba83ce0e8e3f0b7c7a 494 TIGRFAM TIGR00924 yjdL_sub1_fam: amino acid/peptide transporter (Peptide:H+ symporter) 13 490 4.0E-201 T 09-03-2017 IPR005279 Dipeptide/tripeptide permease GO:0015197|GO:0015833|GO:0016020 TK78_RS21785 02f6b60c1577efba83ce0e8e3f0b7c7a 494 Gene3D G3DSA:1.20.1250.20 35 201 1.1E-7 T 09-03-2017 TK78_RS28850 855c8f4dbcdd95cb1e962e806ceef33a 159 SUPERFAMILY SSF102405 2 155 1.92E-16 T 09-03-2017 TK78_RS28850 855c8f4dbcdd95cb1e962e806ceef33a 159 Gene3D G3DSA:3.40.50.450 37 151 1.4E-7 T 09-03-2017 TK78_RS10695 39e2fdd952855e574259845a9713b729 743 Pfam PF00270 DEAD/DEAH box helicase 2 171 1.9E-46 T 09-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 TK78_RS10695 39e2fdd952855e574259845a9713b729 743 SMART SM00487 1 204 3.6E-41 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS10695 39e2fdd952855e574259845a9713b729 743 SUPERFAMILY SSF52540 53 341 3.62E-73 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10695 39e2fdd952855e574259845a9713b729 743 ProSitePatterns PS00039 DEAD-box subfamily ATP-dependent helicases signature. 132 140 - T 09-03-2017 IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site TK78_RS10695 39e2fdd952855e574259845a9713b729 743 Gene3D G3DSA:3.40.50.300 200 354 6.3E-50 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10695 39e2fdd952855e574259845a9713b729 743 SMART SM00490 240 321 2.3E-32 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS10695 39e2fdd952855e574259845a9713b729 743 Pfam PF00271 Helicase conserved C-terminal domain 212 321 2.8E-28 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS10695 39e2fdd952855e574259845a9713b729 743 Gene3D G3DSA:3.40.50.300 2 199 1.6E-61 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS19375 3f2463c54725353babb9466866f32746 255 ProSitePatterns PS00211 ABC transporters family signature. 136 150 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS19375 3f2463c54725353babb9466866f32746 255 SMART SM00382 27 210 2.4E-10 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS19375 3f2463c54725353babb9466866f32746 255 Pfam PF00005 ABC transporter 19 163 9.4E-24 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS19375 3f2463c54725353babb9466866f32746 255 Gene3D G3DSA:3.40.50.300 3 224 2.6E-56 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS19375 3f2463c54725353babb9466866f32746 255 SUPERFAMILY SSF52540 13 216 2.54E-52 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS05645 fd2f87ca8451da25516e0ee695b09c3b 483 ProSitePatterns PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 54 64 - T 09-03-2017 IPR012999 Pyridine nucleotide-disulphide oxidoreductase, class I, active site GO:0016668|GO:0055114 TK78_RS05645 fd2f87ca8451da25516e0ee695b09c3b 483 PIRSF PIRSF000350 1 476 2.0E-71 T 09-03-2017 TK78_RS05645 fd2f87ca8451da25516e0ee695b09c3b 483 Gene3D G3DSA:3.50.50.60 163 350 6.2E-36 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS05645 fd2f87ca8451da25516e0ee695b09c3b 483 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 22 41 6.3E-28 T 09-03-2017 TK78_RS05645 fd2f87ca8451da25516e0ee695b09c3b 483 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 307 329 6.3E-28 T 09-03-2017 TK78_RS05645 fd2f87ca8451da25516e0ee695b09c3b 483 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 276 292 6.3E-28 T 09-03-2017 TK78_RS05645 fd2f87ca8451da25516e0ee695b09c3b 483 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 188 206 6.3E-28 T 09-03-2017 TK78_RS05645 fd2f87ca8451da25516e0ee695b09c3b 483 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 149 167 6.3E-28 T 09-03-2017 TK78_RS05645 fd2f87ca8451da25516e0ee695b09c3b 483 Gene3D G3DSA:3.50.50.60 19 162 4.5E-36 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS05645 fd2f87ca8451da25516e0ee695b09c3b 483 SUPERFAMILY SSF55424 360 480 2.23E-33 T 09-03-2017 IPR016156 FAD/NAD-linked reductase, dimerisation domain GO:0016491|GO:0050660|GO:0055114 TK78_RS05645 fd2f87ca8451da25516e0ee695b09c3b 483 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 53 68 6.1E-67 T 09-03-2017 TK78_RS05645 fd2f87ca8451da25516e0ee695b09c3b 483 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 445 465 6.1E-67 T 09-03-2017 TK78_RS05645 fd2f87ca8451da25516e0ee695b09c3b 483 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 152 161 6.1E-67 T 09-03-2017 TK78_RS05645 fd2f87ca8451da25516e0ee695b09c3b 483 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 360 381 6.1E-67 T 09-03-2017 TK78_RS05645 fd2f87ca8451da25516e0ee695b09c3b 483 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 423 438 6.1E-67 T 09-03-2017 TK78_RS05645 fd2f87ca8451da25516e0ee695b09c3b 483 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 21 43 6.1E-67 T 09-03-2017 TK78_RS05645 fd2f87ca8451da25516e0ee695b09c3b 483 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 322 329 6.1E-67 T 09-03-2017 TK78_RS05645 fd2f87ca8451da25516e0ee695b09c3b 483 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 277 291 6.1E-67 T 09-03-2017 TK78_RS05645 fd2f87ca8451da25516e0ee695b09c3b 483 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 188 213 6.1E-67 T 09-03-2017 TK78_RS05645 fd2f87ca8451da25516e0ee695b09c3b 483 Gene3D G3DSA:3.30.390.30 351 477 5.3E-36 T 09-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 TK78_RS05645 fd2f87ca8451da25516e0ee695b09c3b 483 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 21 344 1.5E-52 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS05645 fd2f87ca8451da25516e0ee695b09c3b 483 TIGRFAM TIGR01350 lipoamide_DH: dihydrolipoyl dehydrogenase 20 480 9.2E-128 T 09-03-2017 IPR006258 Dihydrolipoamide dehydrogenase GO:0004148|GO:0050660|GO:0055114 KEGG: 00010+1.8.1.4|KEGG: 00020+1.8.1.4|KEGG: 00260+1.8.1.4|KEGG: 00280+1.8.1.4|KEGG: 00620+1.8.1.4|KEGG: 00640+1.8.1.4|MetaCyc: PWY-5046|MetaCyc: PWY-5084|Reactome: R-HSA-204174|Reactome: R-HSA-389661|Reactome: R-HSA-5362517|Reactome: R-HSA-6783984|Reactome: R-HSA-70268|Reactome: R-HSA-70895|Reactome: R-HSA-71064|Reactome: R-HSA-71403 TK78_RS05645 fd2f87ca8451da25516e0ee695b09c3b 483 Pfam PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 364 470 8.9E-29 T 09-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 TK78_RS05645 fd2f87ca8451da25516e0ee695b09c3b 483 SUPERFAMILY SSF51905 18 390 4.48E-51 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS06615 22b4602a2ff6c3744a06313c2b2f7970 304 PRINTS PR00146 Dihydrodipicolinate synthase signature 47 68 8.8E-9 T 09-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 TK78_RS06615 22b4602a2ff6c3744a06313c2b2f7970 304 PRINTS PR00146 Dihydrodipicolinate synthase signature 115 131 8.8E-9 T 09-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 TK78_RS06615 22b4602a2ff6c3744a06313c2b2f7970 304 PRINTS PR00146 Dihydrodipicolinate synthase signature 83 101 8.8E-9 T 09-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 TK78_RS06615 22b4602a2ff6c3744a06313c2b2f7970 304 PRINTS PR00146 Dihydrodipicolinate synthase signature 139 156 8.8E-9 T 09-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 TK78_RS06615 22b4602a2ff6c3744a06313c2b2f7970 304 Pfam PF00701 Dihydrodipicolinate synthetase family 15 296 2.7E-41 T 09-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 TK78_RS06615 22b4602a2ff6c3744a06313c2b2f7970 304 PIRSF PIRSF001365 11 303 6.5E-65 T 09-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 TK78_RS06615 22b4602a2ff6c3744a06313c2b2f7970 304 SMART SM01130 13 299 1.5E-77 T 09-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 TK78_RS06615 22b4602a2ff6c3744a06313c2b2f7970 304 SUPERFAMILY SSF51569 11 297 6.07E-73 T 09-03-2017 TK78_RS06615 22b4602a2ff6c3744a06313c2b2f7970 304 Gene3D G3DSA:3.20.20.70 10 298 9.6E-79 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS13915 07068a00383642029dd395c427fb3757 319 SMART SM00342 220 303 1.4E-29 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS13915 07068a00383642029dd395c427fb3757 319 Gene3D G3DSA:1.10.10.60 207 257 1.1E-9 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS13915 07068a00383642029dd395c427fb3757 319 Pfam PF12833 Helix-turn-helix domain 226 304 1.1E-20 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS13915 07068a00383642029dd395c427fb3757 319 Pfam PF12852 Cupin 2 188 5.3E-43 T 09-03-2017 IPR032783 AraC-type transcription regulator, ligand-binding domain TK78_RS13915 07068a00383642029dd395c427fb3757 319 SUPERFAMILY SSF46689 208 254 1.61E-5 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS13915 07068a00383642029dd395c427fb3757 319 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 257 299 - T 09-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 TK78_RS13915 07068a00383642029dd395c427fb3757 319 Gene3D G3DSA:1.10.10.60 258 305 1.4E-13 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS13915 07068a00383642029dd395c427fb3757 319 SUPERFAMILY SSF46689 256 306 5.38E-11 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS14380 7be9efc417e6d4b55618efd3f3211ebc 213 Gene3D G3DSA:1.10.357.10 9 207 4.6E-24 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS14380 7be9efc417e6d4b55618efd3f3211ebc 213 SUPERFAMILY SSF46689 16 86 5.64E-11 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS14380 7be9efc417e6d4b55618efd3f3211ebc 213 SUPERFAMILY SSF48498 97 204 8.9E-8 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS14380 7be9efc417e6d4b55618efd3f3211ebc 213 Pfam PF00440 Bacterial regulatory proteins, tetR family 24 70 2.0E-6 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS07645 79de58101c669bb2fd9deb743db94f70 245 SUPERFAMILY SSF69796 12 238 7.85E-53 T 09-03-2017 IPR003669 Thymidylate synthase ThyX GO:0006231|GO:0050660|GO:0050797 KEGG: 00240+2.1.1.148|KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|KEGG: 00670+2.1.1.148|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6545|MetaCyc: PWY-6936|MetaCyc: PWY-702 TK78_RS07645 79de58101c669bb2fd9deb743db94f70 245 Hamap MF_01408 Thymidylate synthase ThyX [thyX]. 14 245 27.218 T 09-03-2017 IPR003669 Thymidylate synthase ThyX GO:0006231|GO:0050660|GO:0050797 KEGG: 00240+2.1.1.148|KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|KEGG: 00670+2.1.1.148|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6545|MetaCyc: PWY-6936|MetaCyc: PWY-702 TK78_RS07645 79de58101c669bb2fd9deb743db94f70 245 Pfam PF02511 Thymidylate synthase complementing protein 20 231 9.2E-50 T 09-03-2017 IPR003669 Thymidylate synthase ThyX GO:0006231|GO:0050660|GO:0050797 KEGG: 00240+2.1.1.148|KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|KEGG: 00670+2.1.1.148|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6545|MetaCyc: PWY-6936|MetaCyc: PWY-702 TK78_RS07645 79de58101c669bb2fd9deb743db94f70 245 TIGRFAM TIGR02170 thyX: thymidylate synthase, flavin-dependent 18 237 3.9E-63 T 09-03-2017 IPR003669 Thymidylate synthase ThyX GO:0006231|GO:0050660|GO:0050797 KEGG: 00240+2.1.1.148|KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|KEGG: 00670+2.1.1.148|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6545|MetaCyc: PWY-6936|MetaCyc: PWY-702 TK78_RS17470 ea1658b17fab8ff3b99be07b3a0e897d 300 SUPERFAMILY SSF57845 16 47 5.95E-5 T 09-03-2017 TK78_RS17470 ea1658b17fab8ff3b99be07b3a0e897d 300 Gene3D G3DSA:1.20.1540.10 87 264 2.0E-41 T 09-03-2017 IPR022764 Peptidase S54, rhomboid domain GO:0004252|GO:0016021 TK78_RS17470 ea1658b17fab8ff3b99be07b3a0e897d 300 SUPERFAMILY SSF144091 85 272 1.7E-44 T 09-03-2017 TK78_RS17470 ea1658b17fab8ff3b99be07b3a0e897d 300 Pfam PF01694 Rhomboid family 133 266 5.5E-37 T 09-03-2017 IPR022764 Peptidase S54, rhomboid domain GO:0004252|GO:0016021 TK78_RS10515 578358ee1ea56d3aa899d5e4869828f9 371 Pfam PF13180 PDZ domain 138 193 6.8E-11 T 09-03-2017 IPR001478 PDZ domain GO:0005515 TK78_RS10515 578358ee1ea56d3aa899d5e4869828f9 371 SMART SM00228 131 197 1.0E-5 T 09-03-2017 IPR001478 PDZ domain GO:0005515 TK78_RS10515 578358ee1ea56d3aa899d5e4869828f9 371 SUPERFAMILY SSF50156 138 195 3.02E-13 T 09-03-2017 IPR001478 PDZ domain GO:0005515 TK78_RS10515 578358ee1ea56d3aa899d5e4869828f9 371 Gene3D G3DSA:2.30.42.10 131 195 1.8E-13 T 09-03-2017 IPR001478 PDZ domain GO:0005515 TK78_RS10515 578358ee1ea56d3aa899d5e4869828f9 371 Pfam PF05362 Lon protease (S16) C-terminal proteolytic domain 262 349 6.3E-7 T 09-03-2017 IPR008269 Peptidase S16, Lon C-terminal GO:0004176|GO:0004252|GO:0006508 TK78_RS10515 578358ee1ea56d3aa899d5e4869828f9 371 SUPERFAMILY SSF54211 243 354 2.5E-18 T 09-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold TK78_RS10515 578358ee1ea56d3aa899d5e4869828f9 371 Gene3D G3DSA:3.30.230.10 259 353 8.9E-19 T 09-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TK78_RS09525 412f9d994e04f0a7dc1258ffdf00cae4 483 SMART SM00388 270 331 1.6E-9 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS09525 412f9d994e04f0a7dc1258ffdf00cae4 483 Pfam PF00512 His Kinase A (phospho-acceptor) domain 271 331 1.8E-8 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS09525 412f9d994e04f0a7dc1258ffdf00cae4 483 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 375 481 4.4E-22 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09525 412f9d994e04f0a7dc1258ffdf00cae4 483 SMART SM00387 373 483 2.8E-33 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09525 412f9d994e04f0a7dc1258ffdf00cae4 483 Gene3D G3DSA:3.30.565.10 355 481 1.0E-35 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09525 412f9d994e04f0a7dc1258ffdf00cae4 483 PRINTS PR00344 Bacterial sensor protein C-terminal signature 443 461 4.9E-15 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS09525 412f9d994e04f0a7dc1258ffdf00cae4 483 PRINTS PR00344 Bacterial sensor protein C-terminal signature 408 422 4.9E-15 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS09525 412f9d994e04f0a7dc1258ffdf00cae4 483 PRINTS PR00344 Bacterial sensor protein C-terminal signature 426 436 4.9E-15 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS09525 412f9d994e04f0a7dc1258ffdf00cae4 483 PRINTS PR00344 Bacterial sensor protein C-terminal signature 467 480 4.9E-15 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS09525 412f9d994e04f0a7dc1258ffdf00cae4 483 Pfam PF00672 HAMP domain 196 265 7.7E-11 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS09525 412f9d994e04f0a7dc1258ffdf00cae4 483 SMART SM00304 215 269 4.3E-6 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS09525 412f9d994e04f0a7dc1258ffdf00cae4 483 Gene3D G3DSA:1.10.287.130 264 327 3.5E-8 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS09525 412f9d994e04f0a7dc1258ffdf00cae4 483 SUPERFAMILY SSF55874 341 481 1.05E-34 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09525 412f9d994e04f0a7dc1258ffdf00cae4 483 SUPERFAMILY SSF47384 253 332 2.94E-11 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS00590 af268724d210c1b4ef79deaa607d8be3 260 Pfam PF00005 ABC transporter 19 167 2.4E-31 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS00590 af268724d210c1b4ef79deaa607d8be3 260 SMART SM00382 27 212 5.7E-17 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS00590 af268724d210c1b4ef79deaa607d8be3 260 ProSitePatterns PS00211 ABC transporters family signature. 139 153 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS00590 af268724d210c1b4ef79deaa607d8be3 260 Gene3D G3DSA:3.40.50.300 4 231 1.3E-60 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS00590 af268724d210c1b4ef79deaa607d8be3 260 SUPERFAMILY SSF52540 3 225 2.72E-59 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13365 95d5a889c4e906de5de038bf5333d6bc 130 Pfam PF03733 Inner membrane component domain 4 53 5.5E-18 T 09-03-2017 IPR005185 Inner membrane component domain TK78_RS13365 95d5a889c4e906de5de038bf5333d6bc 130 Pfam PF03733 Inner membrane component domain 68 118 2.2E-19 T 09-03-2017 IPR005185 Inner membrane component domain TK78_RS13365 95d5a889c4e906de5de038bf5333d6bc 130 PIRSF PIRSF028777 1 130 9.4E-54 T 09-03-2017 IPR031308 Uncharacterised conserved protein UCP028777 TK78_RS07085 3c54d1514db4b5ac51f659ac5344ab2b 258 SMART SM00824 Thioesterase 26 247 0.0027 T 09-03-2017 IPR020802 Polyketide synthase, thioesterase domain GO:0009058|GO:0016788 TK78_RS07085 3c54d1514db4b5ac51f659ac5344ab2b 258 Gene3D G3DSA:3.40.50.1820 13 247 2.3E-38 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS07085 3c54d1514db4b5ac51f659ac5344ab2b 258 SUPERFAMILY SSF53474 7 247 1.92E-54 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS07085 3c54d1514db4b5ac51f659ac5344ab2b 258 Pfam PF00975 Thioesterase domain 24 243 1.2E-51 T 09-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 TK78_RS17150 f1fbb65ece773e2b634225750258a8e3 159 Pfam PF00293 NUDIX domain 9 102 1.1E-12 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS17150 f1fbb65ece773e2b634225750258a8e3 159 SUPERFAMILY SSF55811 2 112 6.91E-19 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS17150 f1fbb65ece773e2b634225750258a8e3 159 Gene3D G3DSA:3.90.79.10 2 112 1.3E-17 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS24105 40453e859b155ddce63bb31baf00c484 455 Pfam PF13519 von Willebrand factor type A domain 69 178 2.0E-10 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS24105 40453e859b155ddce63bb31baf00c484 455 Gene3D G3DSA:3.40.50.410 69 219 2.2E-11 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS24105 40453e859b155ddce63bb31baf00c484 455 SMART SM00327 66 243 2.6E-13 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS24105 40453e859b155ddce63bb31baf00c484 455 SUPERFAMILY SSF53300 65 243 2.23E-21 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS24520 0ccdf63f33026af6bb73a0e224f08a0e 203 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 15 48 1.7E-5 T 09-03-2017 IPR001451 Hexapeptide repeat TK78_RS24520 0ccdf63f33026af6bb73a0e224f08a0e 203 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 50 85 4.4E-5 T 09-03-2017 IPR001451 Hexapeptide repeat TK78_RS24520 0ccdf63f33026af6bb73a0e224f08a0e 203 Pfam PF14602 Hexapeptide repeat of succinyl-transferase 116 143 0.094 T 09-03-2017 IPR001451 Hexapeptide repeat TK78_RS24520 0ccdf63f33026af6bb73a0e224f08a0e 203 Gene3D G3DSA:2.160.10.10 12 162 1.9E-34 T 09-03-2017 TK78_RS24520 0ccdf63f33026af6bb73a0e224f08a0e 203 SUPERFAMILY SSF51161 4 162 1.18E-37 T 09-03-2017 IPR011004 Trimeric LpxA-like TK78_RS29745 546a17a7f3b300ebc76a7ea264a2cf8e 331 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 2 13 4.4E-7 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS29745 546a17a7f3b300ebc76a7ea264a2cf8e 331 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 37 57 4.4E-7 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS29745 546a17a7f3b300ebc76a7ea264a2cf8e 331 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 13 26 4.4E-7 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS29745 546a17a7f3b300ebc76a7ea264a2cf8e 331 SUPERFAMILY SSF46955 3 104 5.13E-25 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS29745 546a17a7f3b300ebc76a7ea264a2cf8e 331 Gene3D G3DSA:1.25.10.10 118 325 1.3E-12 T 09-03-2017 IPR011989 Armadillo-like helical TK78_RS29745 546a17a7f3b300ebc76a7ea264a2cf8e 331 Pfam PF13646 HEAT repeats 177 249 9.1E-10 T 09-03-2017 TK78_RS29745 546a17a7f3b300ebc76a7ea264a2cf8e 331 ProSitePatterns PS00552 MerR-type HTH domain signature. 4 26 - T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS29745 546a17a7f3b300ebc76a7ea264a2cf8e 331 SMART SM00422 1 70 2.9E-21 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS29745 546a17a7f3b300ebc76a7ea264a2cf8e 331 Pfam PF13411 MerR HTH family regulatory protein 3 68 3.4E-15 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS29745 546a17a7f3b300ebc76a7ea264a2cf8e 331 Gene3D G3DSA:1.10.1660.10 3 104 3.4E-27 T 09-03-2017 TK78_RS29745 546a17a7f3b300ebc76a7ea264a2cf8e 331 SMART SM00567 E-Z type HEAT repeats 186 215 0.35 T 09-03-2017 IPR004155 PBS lyase HEAT-like repeat Reactome: R-HSA-204626 TK78_RS29745 546a17a7f3b300ebc76a7ea264a2cf8e 331 SMART SM00567 E-Z type HEAT repeats 217 246 34.0 T 09-03-2017 IPR004155 PBS lyase HEAT-like repeat Reactome: R-HSA-204626 TK78_RS29745 546a17a7f3b300ebc76a7ea264a2cf8e 331 SUPERFAMILY SSF48371 115 325 2.69E-12 T 09-03-2017 IPR016024 Armadillo-type fold GO:0005488 TK78_RS06365 d522b35db449dc9d47027ce9f02e6b5a 967 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 213 234 3.0E-32 T 09-03-2017 TK78_RS06365 d522b35db449dc9d47027ce9f02e6b5a 967 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 409 428 3.0E-32 T 09-03-2017 TK78_RS06365 d522b35db449dc9d47027ce9f02e6b5a 967 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 303 315 3.0E-32 T 09-03-2017 TK78_RS06365 d522b35db449dc9d47027ce9f02e6b5a 967 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 102 122 3.0E-32 T 09-03-2017 TK78_RS06365 d522b35db449dc9d47027ce9f02e6b5a 967 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 73 98 3.0E-32 T 09-03-2017 TK78_RS06365 d522b35db449dc9d47027ce9f02e6b5a 967 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 235 261 3.0E-32 T 09-03-2017 TK78_RS06365 d522b35db449dc9d47027ce9f02e6b5a 967 Pfam PF04039 Domain related to MnhB subunit of Na+/H+ antiporter 811 932 2.3E-25 T 09-03-2017 IPR007182 Na+/H+ antiporter MnhB subunit-related protein TK78_RS06365 d522b35db449dc9d47027ce9f02e6b5a 967 Pfam PF00662 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus 56 108 2.9E-8 T 09-03-2017 IPR001516 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS06365 d522b35db449dc9d47027ce9f02e6b5a 967 Pfam PF13244 Domain of unknown function (DUF4040) 600 664 8.3E-20 T 09-03-2017 IPR025383 Domain of unknown function DUF4040 TK78_RS06365 d522b35db449dc9d47027ce9f02e6b5a 967 Pfam PF00361 Proton-conducting membrane transporter 125 415 5.4E-60 T 09-03-2017 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS01695 bf614310ef3f823fa9ad72178743f9f4 457 Pfam PF02624 YcaO cyclodehydratase, ATP-ad Mg2+-binding 68 413 5.4E-38 T 09-03-2017 IPR003776 YcaO-like domain TK78_RS31155 ec710bee430b149fc380e4d41383bd1a 120 TIGRFAM TIGR03367 queuosine_QueD: queuosine biosynthesis protein QueD 4 96 9.1E-27 T 09-03-2017 IPR007115 6-pyruvoyl tetrahydropterin synthase/QueD family protein Reactome: R-HSA-1474151 TK78_RS31155 ec710bee430b149fc380e4d41383bd1a 120 Pfam PF01242 6-pyruvoyl tetrahydropterin synthase 4 119 1.1E-31 T 09-03-2017 IPR007115 6-pyruvoyl tetrahydropterin synthase/QueD family protein Reactome: R-HSA-1474151 TK78_RS31155 ec710bee430b149fc380e4d41383bd1a 120 SUPERFAMILY SSF55620 1 119 1.78E-34 T 09-03-2017 TK78_RS31155 ec710bee430b149fc380e4d41383bd1a 120 Gene3D G3DSA:3.30.479.10 1 119 1.3E-35 T 09-03-2017 TK78_RS31155 ec710bee430b149fc380e4d41383bd1a 120 PIRSF PIRSF006113 1 120 2.6E-27 T 09-03-2017 IPR007115 6-pyruvoyl tetrahydropterin synthase/QueD family protein Reactome: R-HSA-1474151 TK78_RS27185 8c719bfc6b67c09441eaea5859be39c1 271 Gene3D G3DSA:3.40.30.10 84 270 3.1E-26 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS27185 8c719bfc6b67c09441eaea5859be39c1 271 SUPERFAMILY SSF52833 82 270 1.3E-17 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS27185 8c719bfc6b67c09441eaea5859be39c1 271 Pfam PF13462 Thioredoxin 83 267 8.0E-42 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS00780 d4432189e79c96401a35d589f6a00870 295 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 246 278 3.3E-6 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS00780 d4432189e79c96401a35d589f6a00870 295 Gene3D G3DSA:3.40.50.300 20 267 8.5E-80 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS00780 d4432189e79c96401a35d589f6a00870 295 Pfam PF00005 ABC transporter 44 194 2.0E-30 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS00780 d4432189e79c96401a35d589f6a00870 295 ProSitePatterns PS00211 ABC transporters family signature. 167 181 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS00780 d4432189e79c96401a35d589f6a00870 295 SMART SM00382 53 244 8.1E-17 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS00780 d4432189e79c96401a35d589f6a00870 295 SUPERFAMILY SSF52540 21 266 2.2E-69 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13655 2a043c1ff38d1abdcb085cd2700dbcef 241 ProDom PD001581 OXIDOREDUCTASE SUBUNIT NADH DEHYDROGENASE CHAIN C NAD DEHYDROGENASE UBIQUINONE F420H2 149 204 3.0E-24 T 09-03-2017 IPR001268 NADH:ubiquinone oxidoreductase, 30kDa subunit GO:0008137|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13655 2a043c1ff38d1abdcb085cd2700dbcef 241 Hamap MF_01357 NAD(P)H-quinone oxidoreductase subunit J, chloroplastic [ndhJ]. 72 229 27.846 T 09-03-2017 IPR010218 NADH dehydrogenase, subunit C GO:0016651|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13655 2a043c1ff38d1abdcb085cd2700dbcef 241 SUPERFAMILY SSF143243 85 236 8.76E-45 T 09-03-2017 TK78_RS13655 2a043c1ff38d1abdcb085cd2700dbcef 241 TIGRFAM TIGR01961 NuoC_fam: NADH (or F420H2) dehydrogenase, subunit C 98 220 1.5E-43 T 09-03-2017 IPR010218 NADH dehydrogenase, subunit C GO:0016651|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13655 2a043c1ff38d1abdcb085cd2700dbcef 241 Pfam PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 100 221 1.0E-39 T 09-03-2017 IPR001268 NADH:ubiquinone oxidoreductase, 30kDa subunit GO:0008137|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS29055 2a9bfd76a9128f2be9291263ed3c03f6 159 SMART SM00422 11 79 1.7E-24 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS29055 2a9bfd76a9128f2be9291263ed3c03f6 159 Gene3D G3DSA:1.10.1660.10 65 131 4.7E-16 T 09-03-2017 TK78_RS29055 2a9bfd76a9128f2be9291263ed3c03f6 159 TIGRFAM TIGR01950 SoxR: redox-sensitive transcriptional activator SoxR 10 149 6.9E-71 T 09-03-2017 IPR010211 Redox-sensitive transcriptional activator SoxR GO:0003677|GO:0006355|GO:0006979|GO:0051537 TK78_RS29055 2a9bfd76a9128f2be9291263ed3c03f6 159 Pfam PF00376 MerR family regulatory protein 12 48 1.3E-10 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS29055 2a9bfd76a9128f2be9291263ed3c03f6 159 SUPERFAMILY SSF46955 11 131 1.54E-27 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS29055 2a9bfd76a9128f2be9291263ed3c03f6 159 Gene3D G3DSA:1.10.1660.10 11 64 1.8E-19 T 09-03-2017 TK78_RS29055 2a9bfd76a9128f2be9291263ed3c03f6 159 Pfam PF09278 MerR, DNA binding 53 118 3.5E-18 T 09-03-2017 IPR015358 Transcription regulator MerR, DNA binding TK78_RS29055 2a9bfd76a9128f2be9291263ed3c03f6 159 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 46 66 2.3E-12 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS29055 2a9bfd76a9128f2be9291263ed3c03f6 159 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 23 36 2.3E-12 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS29055 2a9bfd76a9128f2be9291263ed3c03f6 159 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 12 23 2.3E-12 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS33790 42509ccf1e0cef4e4c70d3491b280c60 426 ProSitePatterns PS00161 Isocitrate lyase signature. 187 192 - T 09-03-2017 IPR018523 Isocitrate lyase/phosphorylmutase, conserved site GO:0003824|GO:0008152 TK78_RS33790 42509ccf1e0cef4e4c70d3491b280c60 426 Pfam PF00463 Isocitrate lyase family 13 249 1.8E-57 T 09-03-2017 IPR006254 Isocitrate lyase GO:0004451|GO:0019752 KEGG: 00630+4.1.3.1|MetaCyc: PWY-6969 TK78_RS33790 42509ccf1e0cef4e4c70d3491b280c60 426 Pfam PF00463 Isocitrate lyase family 250 425 3.2E-51 T 09-03-2017 IPR006254 Isocitrate lyase GO:0004451|GO:0019752 KEGG: 00630+4.1.3.1|MetaCyc: PWY-6969 TK78_RS33790 42509ccf1e0cef4e4c70d3491b280c60 426 SUPERFAMILY SSF51621 7 425 1.75E-160 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS33790 42509ccf1e0cef4e4c70d3491b280c60 426 Gene3D G3DSA:3.20.20.60 9 407 6.4E-167 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS33790 42509ccf1e0cef4e4c70d3491b280c60 426 PIRSF PIRSF001362 1 426 6.6E-239 T 09-03-2017 TK78_RS33790 42509ccf1e0cef4e4c70d3491b280c60 426 TIGRFAM TIGR01346 isocit_lyase: isocitrate lyase 250 425 2.9E-84 T 09-03-2017 IPR006254 Isocitrate lyase GO:0004451|GO:0019752 KEGG: 00630+4.1.3.1|MetaCyc: PWY-6969 TK78_RS33790 42509ccf1e0cef4e4c70d3491b280c60 426 TIGRFAM TIGR01346 isocit_lyase: isocitrate lyase 8 249 3.6E-108 T 09-03-2017 IPR006254 Isocitrate lyase GO:0004451|GO:0019752 KEGG: 00630+4.1.3.1|MetaCyc: PWY-6969 TK78_RS12880 1f5ede2f86157de54772819534653ce6 615 SUPERFAMILY SSF56235 2 233 1.8E-67 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS12880 1f5ede2f86157de54772819534653ce6 615 Gene3D G3DSA:3.40.50.10490 446 615 5.3E-60 T 09-03-2017 TK78_RS12880 1f5ede2f86157de54772819534653ce6 615 Gene3D G3DSA:3.40.50.10490 246 445 7.7E-72 T 09-03-2017 TK78_RS12880 1f5ede2f86157de54772819534653ce6 615 Pfam PF13522 Glutamine amidotransferase domain 66 194 2.1E-21 T 09-03-2017 TK78_RS12880 1f5ede2f86157de54772819534653ce6 615 Pfam PF01380 SIS domain 291 418 9.3E-34 T 09-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 TK78_RS12880 1f5ede2f86157de54772819534653ce6 615 Pfam PF01380 SIS domain 464 596 2.0E-21 T 09-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 TK78_RS12880 1f5ede2f86157de54772819534653ce6 615 TIGRFAM TIGR01135 glmS: glutamine-fructose-6-phosphate transaminase (isomerizing) 2 615 5.9E-245 T 09-03-2017 IPR005855 Glucosamine-fructose-6-phosphate aminotransferase, isomerising GO:0004360|GO:1901137 KEGG: 00250+2.6.1.16|KEGG: 00520+2.6.1.16|MetaCyc: PWY-6749|Reactome: R-HSA-446210 TK78_RS12880 1f5ede2f86157de54772819534653ce6 615 Gene3D G3DSA:3.60.20.10 2 242 3.0E-74 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS12880 1f5ede2f86157de54772819534653ce6 615 SUPERFAMILY SSF53697 247 615 3.06E-105 T 09-03-2017 TK78_RS12880 1f5ede2f86157de54772819534653ce6 615 Hamap MF_00164 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] [glmS]. 1 615 40.738 T 09-03-2017 IPR005855 Glucosamine-fructose-6-phosphate aminotransferase, isomerising GO:0004360|GO:1901137 KEGG: 00250+2.6.1.16|KEGG: 00520+2.6.1.16|MetaCyc: PWY-6749|Reactome: R-HSA-446210 TK78_RS15145 511500a300d3ad8699b4268f35b52840 517 SUPERFAMILY SSF53383 54 505 4.84E-117 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS15145 511500a300d3ad8699b4268f35b52840 517 Gene3D G3DSA:1.20.1650.10 27 101 1.2E-21 T 09-03-2017 TK78_RS15145 511500a300d3ad8699b4268f35b52840 517 Gene3D G3DSA:3.90.1150.10 390 504 1.2E-36 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS15145 511500a300d3ad8699b4268f35b52840 517 Gene3D G3DSA:3.40.640.10 112 389 4.1E-93 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS15145 511500a300d3ad8699b4268f35b52840 517 Pfam PF00282 Pyridoxal-dependent decarboxylase conserved domain 99 436 4.0E-62 T 09-03-2017 IPR002129 Pyridoxal phosphate-dependent decarboxylase GO:0016831|GO:0019752|GO:0030170 TK78_RS15145 511500a300d3ad8699b4268f35b52840 517 PRINTS PR00800 Aromatic-L-amino-acid decarboxylase signature 57 74 2.0E-7 T 09-03-2017 IPR010977 Aromatic-L-amino-acid decarboxylase GO:0006520|GO:0016831 TK78_RS15145 511500a300d3ad8699b4268f35b52840 517 PRINTS PR00800 Aromatic-L-amino-acid decarboxylase signature 375 390 2.0E-7 T 09-03-2017 IPR010977 Aromatic-L-amino-acid decarboxylase GO:0006520|GO:0016831 TK78_RS15145 511500a300d3ad8699b4268f35b52840 517 PRINTS PR00800 Aromatic-L-amino-acid decarboxylase signature 418 437 2.0E-7 T 09-03-2017 IPR010977 Aromatic-L-amino-acid decarboxylase GO:0006520|GO:0016831 TK78_RS15145 511500a300d3ad8699b4268f35b52840 517 PRINTS PR00800 Aromatic-L-amino-acid decarboxylase signature 102 121 2.0E-7 T 09-03-2017 IPR010977 Aromatic-L-amino-acid decarboxylase GO:0006520|GO:0016831 TK78_RS29515 09dd24087fc88973b39c92fdbaa1be65 873 SUPERFAMILY SSF53850 333 595 1.15E-74 T 09-03-2017 TK78_RS29515 09dd24087fc88973b39c92fdbaa1be65 873 SUPERFAMILY SSF161098 83 265 4.71E-38 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS29515 09dd24087fc88973b39c92fdbaa1be65 873 Pfam PF04069 Substrate binding domain of ABC-type glycine betaine transport system 338 586 1.0E-65 T 09-03-2017 IPR007210 ABC-type glycine betaine transport system, substrate-binding domain GO:0005215|GO:0006810 TK78_RS29515 09dd24087fc88973b39c92fdbaa1be65 873 Pfam PF04069 Substrate binding domain of ABC-type glycine betaine transport system 615 861 2.6E-61 T 09-03-2017 IPR007210 ABC-type glycine betaine transport system, substrate-binding domain GO:0005215|GO:0006810 TK78_RS29515 09dd24087fc88973b39c92fdbaa1be65 873 Gene3D G3DSA:3.40.190.100 698 821 1.1E-34 T 09-03-2017 TK78_RS29515 09dd24087fc88973b39c92fdbaa1be65 873 Gene3D G3DSA:3.40.190.100 423 538 5.6E-35 T 09-03-2017 TK78_RS29515 09dd24087fc88973b39c92fdbaa1be65 873 Gene3D G3DSA:1.10.3720.10 77 261 1.6E-42 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS29515 09dd24087fc88973b39c92fdbaa1be65 873 SUPERFAMILY SSF53850 611 870 5.67E-71 T 09-03-2017 TK78_RS29515 09dd24087fc88973b39c92fdbaa1be65 873 Gene3D G3DSA:3.40.190.10 612 694 2.3E-30 T 09-03-2017 TK78_RS29515 09dd24087fc88973b39c92fdbaa1be65 873 Gene3D G3DSA:3.40.190.10 539 598 6.4E-69 T 09-03-2017 TK78_RS29515 09dd24087fc88973b39c92fdbaa1be65 873 Gene3D G3DSA:3.40.190.10 335 419 6.4E-69 T 09-03-2017 TK78_RS29515 09dd24087fc88973b39c92fdbaa1be65 873 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 105 261 3.5E-21 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS22745 071e6218a572a43bbf5f7f2e2d7dadbf 486 Pfam PF04286 Protein of unknown function (DUF445) 121 483 7.6E-100 T 09-03-2017 IPR007383 Protein of unknown function DUF445 TK78_RS33375 12c85a5899da6f23f6c1037d7bb20714 335 Gene3D G3DSA:3.40.50.720 19 204 2.8E-44 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS33375 12c85a5899da6f23f6c1037d7bb20714 335 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 25 197 4.3E-44 T 09-03-2017 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS33375 12c85a5899da6f23f6c1037d7bb20714 335 SUPERFAMILY SSF51735 22 199 9.4E-48 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS33375 12c85a5899da6f23f6c1037d7bb20714 335 Gene3D G3DSA:1.10.1040.10 205 279 2.6E-8 T 09-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 TK78_RS33375 12c85a5899da6f23f6c1037d7bb20714 335 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 203 271 6.1E-14 T 09-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS33375 12c85a5899da6f23f6c1037d7bb20714 335 SUPERFAMILY SSF48179 203 288 3.06E-13 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS33375 12c85a5899da6f23f6c1037d7bb20714 335 Hamap MF_02129 L-carnitine dehydrogenase [lcdH]. 23 335 50.881 T 09-03-2017 IPR026578 L-carnitine dehydrogenase KEGG: 00040+1.1.1.10|MetaCyc: PWY-3602|MetaCyc: PWY-5515|MetaCyc: PWY-5525|MetaCyc: PWY-7472 TK78_RS26715 67475cc381a9ab24379d19fdb3c87cd0 1051 PRINTS PR00702 Acriflavin resistance protein family signature 364 385 8.0E-42 T 09-03-2017 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 TK78_RS26715 67475cc381a9ab24379d19fdb3c87cd0 1051 PRINTS PR00702 Acriflavin resistance protein family signature 39 57 8.0E-42 T 09-03-2017 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 TK78_RS26715 67475cc381a9ab24379d19fdb3c87cd0 1051 PRINTS PR00702 Acriflavin resistance protein family signature 11 35 8.0E-42 T 09-03-2017 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 TK78_RS26715 67475cc381a9ab24379d19fdb3c87cd0 1051 PRINTS PR00702 Acriflavin resistance protein family signature 337 360 8.0E-42 T 09-03-2017 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 TK78_RS26715 67475cc381a9ab24379d19fdb3c87cd0 1051 PRINTS PR00702 Acriflavin resistance protein family signature 445 468 8.0E-42 T 09-03-2017 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 TK78_RS26715 67475cc381a9ab24379d19fdb3c87cd0 1051 PRINTS PR00702 Acriflavin resistance protein family signature 470 493 8.0E-42 T 09-03-2017 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 TK78_RS26715 67475cc381a9ab24379d19fdb3c87cd0 1051 PRINTS PR00702 Acriflavin resistance protein family signature 392 416 8.0E-42 T 09-03-2017 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 TK78_RS26715 67475cc381a9ab24379d19fdb3c87cd0 1051 SUPERFAMILY SSF82693 569 664 3.82E-9 T 09-03-2017 TK78_RS26715 67475cc381a9ab24379d19fdb3c87cd0 1051 SUPERFAMILY SSF82714 183 271 1.96E-10 T 09-03-2017 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains TK78_RS26715 67475cc381a9ab24379d19fdb3c87cd0 1051 SUPERFAMILY SSF82866 791 1017 1.57E-50 T 09-03-2017 TK78_RS26715 67475cc381a9ab24379d19fdb3c87cd0 1051 Gene3D G3DSA:3.30.2090.10 183 271 1.7E-10 T 09-03-2017 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains TK78_RS26715 67475cc381a9ab24379d19fdb3c87cd0 1051 SUPERFAMILY SSF82866 299 498 1.83E-41 T 09-03-2017 TK78_RS26715 67475cc381a9ab24379d19fdb3c87cd0 1051 Gene3D G3DSA:3.30.70.1430 41 136 6.5E-23 T 09-03-2017 TK78_RS26715 67475cc381a9ab24379d19fdb3c87cd0 1051 Pfam PF00873 AcrB/AcrD/AcrF family 5 1013 1.2E-218 T 09-03-2017 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 TK78_RS26715 67475cc381a9ab24379d19fdb3c87cd0 1051 SUPERFAMILY SSF82693 41 130 8.63E-21 T 09-03-2017 TK78_RS26715 67475cc381a9ab24379d19fdb3c87cd0 1051 Gene3D G3DSA:3.30.70.1430 571 662 1.2E-9 T 09-03-2017 TK78_RS26715 67475cc381a9ab24379d19fdb3c87cd0 1051 Gene3D G3DSA:1.10.3850.10 800 1014 2.7E-58 T 09-03-2017 TK78_RS26715 67475cc381a9ab24379d19fdb3c87cd0 1051 Gene3D G3DSA:1.10.3850.10 279 498 4.2E-57 T 09-03-2017 TK78_RS26715 67475cc381a9ab24379d19fdb3c87cd0 1051 SUPERFAMILY SSF82693 275 330 5.49E-15 T 09-03-2017 TK78_RS26715 67475cc381a9ab24379d19fdb3c87cd0 1051 SUPERFAMILY SSF82693 135 181 5.49E-15 T 09-03-2017 TK78_RS20375 a0299e9eb0fc6d69692a24be08d5728b 289 Pfam PF03476 MOSC N-terminal beta barrel domain 1 122 1.8E-30 T 09-03-2017 IPR005303 MOSC, N-terminal beta barrel TK78_RS20375 a0299e9eb0fc6d69692a24be08d5728b 289 SUPERFAMILY SSF141673 6 135 1.31E-31 T 09-03-2017 TK78_RS20375 a0299e9eb0fc6d69692a24be08d5728b 289 Pfam PF03473 MOSC domain 145 279 4.2E-26 T 09-03-2017 IPR005302 Molybdenum cofactor sulfurase, C-terminal GO:0003824|GO:0030151|GO:0030170 TK78_RS20375 a0299e9eb0fc6d69692a24be08d5728b 289 SUPERFAMILY SSF50800 2 48 2.58E-16 T 09-03-2017 IPR011037 Pyruvate kinase-like, insert domain TK78_RS20375 a0299e9eb0fc6d69692a24be08d5728b 289 SUPERFAMILY SSF50800 152 282 2.58E-16 T 09-03-2017 IPR011037 Pyruvate kinase-like, insert domain TK78_RS29660 ca193a62ff4fd82725874c664eb0d401 581 SUPERFAMILY SSF53335 127 428 1.75E-44 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS29660 ca193a62ff4fd82725874c664eb0d401 581 Gene3D G3DSA:3.40.50.150 153 327 2.8E-24 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS29660 ca193a62ff4fd82725874c664eb0d401 581 Pfam PF02384 N-6 DNA Methylase 164 363 2.5E-29 T 09-03-2017 IPR003356 DNA methylase, adenine-specific GO:0003677|GO:0006306|GO:0008170 TK78_RS29660 ca193a62ff4fd82725874c664eb0d401 581 PRINTS PR00507 N12 class N6 adenine-specific DNA methyltransferase signature 238 250 9.9E-9 T 09-03-2017 TK78_RS29660 ca193a62ff4fd82725874c664eb0d401 581 PRINTS PR00507 N12 class N6 adenine-specific DNA methyltransferase signature 171 185 9.9E-9 T 09-03-2017 TK78_RS29660 ca193a62ff4fd82725874c664eb0d401 581 PRINTS PR00507 N12 class N6 adenine-specific DNA methyltransferase signature 272 296 9.9E-9 T 09-03-2017 TK78_RS28280 e6fda205dd23b015ab71f96f3bbe825a 532 ProSitePatterns PS00211 ABC transporters family signature. 159 173 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS28280 e6fda205dd23b015ab71f96f3bbe825a 532 Gene3D G3DSA:3.40.50.300 5 99 8.0E-45 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28280 e6fda205dd23b015ab71f96f3bbe825a 532 Gene3D G3DSA:3.40.50.300 135 281 8.0E-45 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28280 e6fda205dd23b015ab71f96f3bbe825a 532 Gene3D G3DSA:3.40.50.300 328 516 4.1E-43 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28280 e6fda205dd23b015ab71f96f3bbe825a 532 Pfam PF00005 ABC transporter 19 187 1.7E-24 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS28280 e6fda205dd23b015ab71f96f3bbe825a 532 Pfam PF00005 ABC transporter 342 471 3.0E-25 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS28280 e6fda205dd23b015ab71f96f3bbe825a 532 SUPERFAMILY SSF52540 330 517 6.82E-47 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28280 e6fda205dd23b015ab71f96f3bbe825a 532 SMART SM00382 350 515 9.9E-10 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS28280 e6fda205dd23b015ab71f96f3bbe825a 532 SMART SM00382 26 232 1.0E-11 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS28280 e6fda205dd23b015ab71f96f3bbe825a 532 SUPERFAMILY SSF52540 3 230 2.38E-43 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28280 e6fda205dd23b015ab71f96f3bbe825a 532 ProSitePatterns PS00211 ABC transporters family signature. 443 457 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS28280 e6fda205dd23b015ab71f96f3bbe825a 532 Pfam PF12848 ABC transporter 230 304 2.2E-7 T 09-03-2017 IPR032781 ABC-transporter extension domain TK78_RS21530 260a59ea2160e1d6eb1c59c0bd4387d8 767 Pfam PF02384 N-6 DNA Methylase 209 444 4.1E-25 T 09-03-2017 IPR003356 DNA methylase, adenine-specific GO:0003677|GO:0006306|GO:0008170 TK78_RS21530 260a59ea2160e1d6eb1c59c0bd4387d8 767 Gene3D G3DSA:3.40.50.150 212 425 1.3E-20 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS21530 260a59ea2160e1d6eb1c59c0bd4387d8 767 SUPERFAMILY SSF53335 209 534 5.47E-46 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS21530 260a59ea2160e1d6eb1c59c0bd4387d8 767 SUPERFAMILY SSF116734 637 754 6.98E-6 T 09-03-2017 TK78_RS21530 260a59ea2160e1d6eb1c59c0bd4387d8 767 PRINTS PR00507 N12 class N6 adenine-specific DNA methyltransferase signature 370 394 6.8E-12 T 09-03-2017 TK78_RS21530 260a59ea2160e1d6eb1c59c0bd4387d8 767 PRINTS PR00507 N12 class N6 adenine-specific DNA methyltransferase signature 226 242 6.8E-12 T 09-03-2017 TK78_RS21530 260a59ea2160e1d6eb1c59c0bd4387d8 767 PRINTS PR00507 N12 class N6 adenine-specific DNA methyltransferase signature 260 274 6.8E-12 T 09-03-2017 TK78_RS21530 260a59ea2160e1d6eb1c59c0bd4387d8 767 PRINTS PR00507 N12 class N6 adenine-specific DNA methyltransferase signature 336 348 6.8E-12 T 09-03-2017 TK78_RS33570 8536ffee27169df5b6d6a24623bd0e59 152 Pfam PF03780 Asp23 family, cell envelope-related function 20 132 5.3E-28 T 09-03-2017 IPR005531 Alkaline shock protein Asp23 TK78_RS16045 9bcef21f025b61c36c5f177a0c070d62 863 Pfam PF10431 C-terminal, D2-small domain, of ClpB protein 770 850 1.8E-26 T 09-03-2017 IPR019489 Clp ATPase, C-terminal TK78_RS16045 9bcef21f025b61c36c5f177a0c070d62 863 Gene3D G3DSA:1.10.1780.10 4 149 1.7E-32 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS16045 9bcef21f025b61c36c5f177a0c070d62 863 ProSitePatterns PS00871 Chaperonins clpA/B signature 2. 637 655 - T 09-03-2017 IPR028299 ClpA/B, conserved site 2 TK78_RS16045 9bcef21f025b61c36c5f177a0c070d62 863 Gene3D G3DSA:1.10.8.60 782 859 3.5E-30 T 09-03-2017 TK78_RS16045 9bcef21f025b61c36c5f177a0c070d62 863 SUPERFAMILY SSF52540 160 551 4.64E-92 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS16045 9bcef21f025b61c36c5f177a0c070d62 863 Gene3D G3DSA:3.40.50.300 558 781 1.6E-54 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS16045 9bcef21f025b61c36c5f177a0c070d62 863 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 19 69 5.3E-5 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS16045 9bcef21f025b61c36c5f177a0c070d62 863 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 95 146 1.2E-11 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS16045 9bcef21f025b61c36c5f177a0c070d62 863 Pfam PF07724 AAA domain (Cdc48 subfamily) 602 763 1.6E-52 T 09-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 TK78_RS16045 9bcef21f025b61c36c5f177a0c070d62 863 SMART SM01086 770 859 3.6E-37 T 09-03-2017 IPR019489 Clp ATPase, C-terminal TK78_RS16045 9bcef21f025b61c36c5f177a0c070d62 863 SUPERFAMILY SSF81923 4 157 2.85E-30 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS16045 9bcef21f025b61c36c5f177a0c070d62 863 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 714 728 3.7E-42 T 09-03-2017 IPR001270 ClpA/B family GO:0005524 TK78_RS16045 9bcef21f025b61c36c5f177a0c070d62 863 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 607 625 3.7E-42 T 09-03-2017 IPR001270 ClpA/B family GO:0005524 TK78_RS16045 9bcef21f025b61c36c5f177a0c070d62 863 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 652 670 3.7E-42 T 09-03-2017 IPR001270 ClpA/B family GO:0005524 TK78_RS16045 9bcef21f025b61c36c5f177a0c070d62 863 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 681 699 3.7E-42 T 09-03-2017 IPR001270 ClpA/B family GO:0005524 TK78_RS16045 9bcef21f025b61c36c5f177a0c070d62 863 SMART SM00382 603 750 1.0E-13 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS16045 9bcef21f025b61c36c5f177a0c070d62 863 SMART SM00382 199 345 5.8E-8 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS16045 9bcef21f025b61c36c5f177a0c070d62 863 SUPERFAMILY SSF52540 552 856 3.63E-77 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS16045 9bcef21f025b61c36c5f177a0c070d62 863 ProSitePatterns PS00870 Chaperonins clpA/B signature 1. 296 308 - T 09-03-2017 IPR018368 ClpA/B, conserved site 1 GO:0005524 TK78_RS16045 9bcef21f025b61c36c5f177a0c070d62 863 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 204 338 7.0E-12 T 09-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 TK78_RS16045 9bcef21f025b61c36c5f177a0c070d62 863 Gene3D G3DSA:3.40.50.300 160 343 3.0E-50 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS16045 9bcef21f025b61c36c5f177a0c070d62 863 Gene3D G3DSA:1.10.8.60 345 428 2.2E-35 T 09-03-2017 TK78_RS16045 9bcef21f025b61c36c5f177a0c070d62 863 TIGRFAM TIGR03346 chaperone_ClpB: ATP-dependent chaperone protein ClpB 5 858 0.0 T 09-03-2017 IPR017730 Chaperonin ClpB GO:0005737|GO:0009408|GO:0016485 TK78_RS33975 a16655a88df002411857f54f4c72d592 699 Gene3D G3DSA:3.90.1170.50 7 114 4.6E-30 T 09-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead TK78_RS33975 a16655a88df002411857f54f4c72d592 699 Pfam PF01315 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain 23 126 5.0E-17 T 09-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead TK78_RS33975 a16655a88df002411857f54f4c72d592 699 Gene3D G3DSA:3.30.365.10 434 525 8.0E-24 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS33975 a16655a88df002411857f54f4c72d592 699 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 153 524 2.0E-90 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS33975 a16655a88df002411857f54f4c72d592 699 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 534 637 2.8E-22 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS33975 a16655a88df002411857f54f4c72d592 699 Gene3D G3DSA:3.30.365.10 274 302 1.2E-6 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS33975 a16655a88df002411857f54f4c72d592 699 Gene3D G3DSA:3.30.365.10 115 166 1.2E-6 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS33975 a16655a88df002411857f54f4c72d592 699 SMART SM01008 23 127 1.1E-27 T 09-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead TK78_RS33975 a16655a88df002411857f54f4c72d592 699 Gene3D G3DSA:3.30.365.10 167 267 2.3E-35 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS33975 a16655a88df002411857f54f4c72d592 699 Gene3D G3DSA:3.30.365.10 552 694 3.0E-54 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS33975 a16655a88df002411857f54f4c72d592 699 Gene3D G3DSA:3.30.365.10 347 433 3.0E-54 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS33975 a16655a88df002411857f54f4c72d592 699 SUPERFAMILY SSF54665 7 134 1.57E-30 T 09-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead TK78_RS33975 a16655a88df002411857f54f4c72d592 699 SUPERFAMILY SSF56003 121 698 4.06E-154 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS13710 77d3c1c4f3d50d7e909d480a39a14fff 308 Gene3D G3DSA:3.60.130.10 39 307 8.4E-90 T 09-03-2017 TK78_RS13710 77d3c1c4f3d50d7e909d480a39a14fff 308 SUPERFAMILY SSF51197 42 307 5.49E-88 T 09-03-2017 TK78_RS13710 77d3c1c4f3d50d7e909d480a39a14fff 308 Pfam PF02668 Taurine catabolism dioxygenase TauD, TfdA family 46 298 1.2E-60 T 09-03-2017 IPR003819 TauD/TfdA-like domain GO:0016491|GO:0055114 Reactome: R-HSA-71262 TK78_RS07495 46e0fc686f9cd4b8e70a193b3362e6e3 372 PRINTS PR00142 RecA protein signature 298 315 1.5E-85 T 09-03-2017 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 TK78_RS07495 46e0fc686f9cd4b8e70a193b3362e6e3 372 PRINTS PR00142 RecA protein signature 166 195 1.5E-85 T 09-03-2017 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 TK78_RS07495 46e0fc686f9cd4b8e70a193b3362e6e3 372 PRINTS PR00142 RecA protein signature 94 123 1.5E-85 T 09-03-2017 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 TK78_RS07495 46e0fc686f9cd4b8e70a193b3362e6e3 372 PRINTS PR00142 RecA protein signature 128 157 1.5E-85 T 09-03-2017 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 TK78_RS07495 46e0fc686f9cd4b8e70a193b3362e6e3 372 PRINTS PR00142 RecA protein signature 211 239 1.5E-85 T 09-03-2017 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 TK78_RS07495 46e0fc686f9cd4b8e70a193b3362e6e3 372 PRINTS PR00142 RecA protein signature 244 273 1.5E-85 T 09-03-2017 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 TK78_RS07495 46e0fc686f9cd4b8e70a193b3362e6e3 372 Gene3D G3DSA:3.40.50.300 28 268 5.5E-88 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07495 46e0fc686f9cd4b8e70a193b3362e6e3 372 Gene3D G3DSA:3.30.250.10 269 327 4.3E-29 T 09-03-2017 IPR023400 DNA recombination and repair protein RecA, C-terminal TK78_RS07495 46e0fc686f9cd4b8e70a193b3362e6e3 372 SUPERFAMILY SSF54752 269 327 3.4E-21 T 09-03-2017 IPR023400 DNA recombination and repair protein RecA, C-terminal TK78_RS07495 46e0fc686f9cd4b8e70a193b3362e6e3 372 SMART SM00382 58 229 3.4E-11 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS07495 46e0fc686f9cd4b8e70a193b3362e6e3 372 ProSitePatterns PS00321 recA signature. 214 222 - T 09-03-2017 IPR020584 DNA recombination/repair protein RecA, conserved site GO:0003677|GO:0005524|GO:0006259|GO:0008094 TK78_RS07495 46e0fc686f9cd4b8e70a193b3362e6e3 372 TIGRFAM TIGR02012 tigrfam_recA: protein RecA 5 324 1.9E-175 T 09-03-2017 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 TK78_RS07495 46e0fc686f9cd4b8e70a193b3362e6e3 372 SUPERFAMILY SSF52540 5 268 5.89E-70 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07495 46e0fc686f9cd4b8e70a193b3362e6e3 372 Hamap MF_00268 Protein RecA [recA]. 6 330 53.225 T 09-03-2017 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 TK78_RS07495 46e0fc686f9cd4b8e70a193b3362e6e3 372 Pfam PF00154 recA bacterial DNA recombination protein 8 269 4.9E-144 T 09-03-2017 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 TK78_RS09310 95892761b39eca9a9bf26b9edb4c93d2 640 SMART SM00860 47 586 1.2E-5 T 09-03-2017 IPR018958 SMI1/KNR4-like domain TK78_RS09310 95892761b39eca9a9bf26b9edb4c93d2 640 SUPERFAMILY SSF160631 41 183 5.23E-12 T 09-03-2017 TK78_RS09310 95892761b39eca9a9bf26b9edb4c93d2 640 Gene3D G3DSA:3.40.1580.10 46 183 6.5E-7 T 09-03-2017 IPR018958 SMI1/KNR4-like domain TK78_RS08225 fb364bfd85f0557d1ed3f1eb7c3dcbc4 473 ProSitePatterns PS00217 Sugar transport proteins signature 2. 123 148 - T 09-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 TK78_RS08225 fb364bfd85f0557d1ed3f1eb7c3dcbc4 473 SUPERFAMILY SSF103473 19 472 2.35E-72 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS08225 fb364bfd85f0557d1ed3f1eb7c3dcbc4 473 Gene3D G3DSA:1.20.1250.20 30 225 7.6E-24 T 09-03-2017 TK78_RS08225 fb364bfd85f0557d1ed3f1eb7c3dcbc4 473 Gene3D G3DSA:1.20.1250.20 276 471 1.8E-20 T 09-03-2017 TK78_RS08225 fb364bfd85f0557d1ed3f1eb7c3dcbc4 473 Pfam PF00083 Sugar (and other) transporter 28 472 3.7E-106 T 09-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 TK78_RS08225 fb364bfd85f0557d1ed3f1eb7c3dcbc4 473 TIGRFAM TIGR00879 SP: MFS transporter, sugar porter (SP) family 22 472 1.8E-102 T 09-03-2017 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 TK78_RS08225 fb364bfd85f0557d1ed3f1eb7c3dcbc4 473 ProSitePatterns PS00216 Sugar transport proteins signature 1. 329 346 - T 09-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 TK78_RS08225 fb364bfd85f0557d1ed3f1eb7c3dcbc4 473 PRINTS PR00171 Sugar transporter signature 378 399 1.2E-21 T 09-03-2017 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 TK78_RS08225 fb364bfd85f0557d1ed3f1eb7c3dcbc4 473 PRINTS PR00171 Sugar transporter signature 35 45 1.2E-21 T 09-03-2017 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 TK78_RS08225 fb364bfd85f0557d1ed3f1eb7c3dcbc4 473 PRINTS PR00171 Sugar transporter signature 285 295 1.2E-21 T 09-03-2017 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 TK78_RS08225 fb364bfd85f0557d1ed3f1eb7c3dcbc4 473 PRINTS PR00171 Sugar transporter signature 118 137 1.2E-21 T 09-03-2017 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 TK78_RS08225 fb364bfd85f0557d1ed3f1eb7c3dcbc4 473 PRINTS PR00171 Sugar transporter signature 401 413 1.2E-21 T 09-03-2017 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 TK78_RS34685 06d3c8d0d7a33a21884ab5d0ee56fbad 81 Pfam PF00293 NUDIX domain 13 74 9.9E-10 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS34685 06d3c8d0d7a33a21884ab5d0ee56fbad 81 Gene3D G3DSA:3.90.79.10 11 77 2.6E-13 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS34685 06d3c8d0d7a33a21884ab5d0ee56fbad 81 SUPERFAMILY SSF55811 11 76 1.9E-14 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS34555 81035beb5a8c6c18d9538155ad5b6ce1 245 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 88 224 1.4E-10 T 09-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 TK78_RS34555 81035beb5a8c6c18d9538155ad5b6ce1 245 SUPERFAMILY SSF46689 15 83 3.02E-11 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS34555 81035beb5a8c6c18d9538155ad5b6ce1 245 Gene3D G3DSA:1.10.10.60 11 81 3.7E-15 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS34555 81035beb5a8c6c18d9538155ad5b6ce1 245 Pfam PF00440 Bacterial regulatory proteins, tetR family 28 74 5.6E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS34555 81035beb5a8c6c18d9538155ad5b6ce1 245 Gene3D G3DSA:1.10.357.10 86 231 1.4E-51 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS34555 81035beb5a8c6c18d9538155ad5b6ce1 245 SUPERFAMILY SSF48498 90 231 5.11E-24 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS26960 7afcfc37a1ffeb04a00d75647cd9ff22 62 TIGRFAM TIGR01683 thiS: thiamine biosynthesis protein ThiS 1 62 8.2E-20 T 09-03-2017 IPR010035 ThiS, thiamine-biosynthesis TK78_RS26960 7afcfc37a1ffeb04a00d75647cd9ff22 62 Pfam PF02597 ThiS family 2 62 1.1E-13 T 09-03-2017 IPR003749 ThiamineS/Molybdopterin converting factor subunit 1 Reactome: R-HSA-947581 TK78_RS26960 7afcfc37a1ffeb04a00d75647cd9ff22 62 Gene3D G3DSA:3.10.20.30 1 62 2.5E-23 T 09-03-2017 IPR012675 Beta-grasp domain TK78_RS26960 7afcfc37a1ffeb04a00d75647cd9ff22 62 SUPERFAMILY SSF54285 1 62 7.27E-15 T 09-03-2017 IPR016155 Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp TK78_RS03430 dd713387c5201c8ecef8dba1597c7670 353 Gene3D G3DSA:3.30.470.30 32 146 3.9E-27 T 09-03-2017 TK78_RS03430 dd713387c5201c8ecef8dba1597c7670 353 Pfam PF04679 ATP dependent DNA ligase C terminal region 215 328 1.3E-15 T 09-03-2017 IPR012309 DNA ligase, ATP-dependent, C-terminal GO:0003910|GO:0006281|GO:0006310 TK78_RS03430 dd713387c5201c8ecef8dba1597c7670 353 Gene3D G3DSA:3.30.1490.70 3 31 3.5E-12 T 09-03-2017 TK78_RS03430 dd713387c5201c8ecef8dba1597c7670 353 Gene3D G3DSA:3.30.1490.70 156 198 3.5E-12 T 09-03-2017 TK78_RS03430 dd713387c5201c8ecef8dba1597c7670 353 Pfam PF01068 ATP dependent DNA ligase domain 11 197 2.3E-37 T 09-03-2017 IPR012310 DNA ligase, ATP-dependent, central GO:0003910|GO:0005524|GO:0006281|GO:0006310 TK78_RS03430 dd713387c5201c8ecef8dba1597c7670 353 SUPERFAMILY SSF56091 6 197 3.08E-41 T 09-03-2017 TK78_RS03430 dd713387c5201c8ecef8dba1597c7670 353 SUPERFAMILY SSF50249 200 337 1.2E-12 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS03430 dd713387c5201c8ecef8dba1597c7670 353 Gene3D G3DSA:2.40.50.140 200 334 6.4E-14 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS03430 dd713387c5201c8ecef8dba1597c7670 353 ProSitePatterns PS00697 ATP-dependent DNA ligase AMP-binding site. 27 35 - T 09-03-2017 IPR016059 DNA ligase, ATP-dependent, conserved site GO:0003909|GO:0051103 TK78_RS19225 ea109574e371cf5ddce7e0ba08f975a2 307 SUPERFAMILY SSF54211 24 176 9.11E-17 T 09-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold TK78_RS19225 ea109574e371cf5ddce7e0ba08f975a2 307 PIRSF PIRSF033887 10 302 9.7E-93 T 09-03-2017 IPR012363 Propanediol utilisation/coumermycin biosynthesis, PduX-related KEGG: 00040+2.7.1.17|KEGG: 00860+2.7.1.177|MetaCyc: PWY-5443 TK78_RS19225 ea109574e371cf5ddce7e0ba08f975a2 307 Pfam PF00288 GHMP kinases N terminal domain 96 130 5.7E-7 T 09-03-2017 IPR006204 GHMP kinase N-terminal domain GO:0005524 TK78_RS19225 ea109574e371cf5ddce7e0ba08f975a2 307 Gene3D G3DSA:3.30.230.10 78 143 4.9E-7 T 09-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TK78_RS09765 b5b621e4b1918a546e4fb67d820529dc 356 PIRSF PIRSF038945 1 355 1.7E-166 T 09-03-2017 IPR026260 Threonine synthase, bacterial/archaeal GO:0004795|GO:0009088 KEGG: 00260+4.2.3.1|KEGG: 00750+4.2.3.1 TK78_RS09765 b5b621e4b1918a546e4fb67d820529dc 356 Gene3D G3DSA:3.40.50.1100 65 149 2.2E-42 T 09-03-2017 TK78_RS09765 b5b621e4b1918a546e4fb67d820529dc 356 ProSitePatterns PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 57 70 - T 09-03-2017 IPR000634 Serine/threonine dehydratase, pyridoxal-phosphate-binding site GO:0006520|GO:0030170 TK78_RS09765 b5b621e4b1918a546e4fb67d820529dc 356 SUPERFAMILY SSF53686 8 337 2.62E-102 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS09765 b5b621e4b1918a546e4fb67d820529dc 356 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 30 323 4.8E-73 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS09765 b5b621e4b1918a546e4fb67d820529dc 356 TIGRFAM TIGR00260 thrC: threonine synthase 13 330 2.5E-97 T 09-03-2017 IPR004450 Threonine synthase-like TK78_RS09765 b5b621e4b1918a546e4fb67d820529dc 356 Gene3D G3DSA:3.40.50.1100 150 331 1.2E-48 T 09-03-2017 TK78_RS19300 03962c170432ff1223fa5ffff2c216ce 174 SUPERFAMILY SSF47598 109 172 6.3E-10 T 09-03-2017 IPR010985 Ribbon-helix-helix GO:0006355 TK78_RS19300 03962c170432ff1223fa5ffff2c216ce 174 Gene3D G3DSA:1.10.1220.10 110 155 2.0E-8 T 09-03-2017 IPR013321 Arc-type ribbon-helix-helix GO:0006355 TK78_RS19300 03962c170432ff1223fa5ffff2c216ce 174 Pfam PF05534 HicB family 114 144 2.1E-4 T 09-03-2017 IPR008651 Uncharacterised protein family HicB TK78_RS03165 81ec4637532445af5889d86d575e31d4 261 ProSitePatterns PS00211 ABC transporters family signature. 165 179 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS03165 81ec4637532445af5889d86d575e31d4 261 SUPERFAMILY SSF52540 53 255 9.24E-42 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03165 81ec4637532445af5889d86d575e31d4 261 Gene3D G3DSA:3.40.50.300 53 257 2.6E-43 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03165 81ec4637532445af5889d86d575e31d4 261 Pfam PF00005 ABC transporter 59 192 1.0E-16 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS03165 81ec4637532445af5889d86d575e31d4 261 SMART SM00382 67 241 1.1E-12 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS20350 0c7b2a0db09e1146a6d00b7eff001283 440 Gene3D G3DSA:3.40.50.720 197 436 3.0E-62 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS20350 0c7b2a0db09e1146a6d00b7eff001283 440 Gene3D G3DSA:3.40.50.720 89 186 5.8E-4 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS20350 0c7b2a0db09e1146a6d00b7eff001283 440 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 325 333 1.5E-8 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20350 0c7b2a0db09e1146a6d00b7eff001283 440 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 345 364 1.5E-8 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20350 0c7b2a0db09e1146a6d00b7eff001283 440 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 272 283 1.5E-8 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20350 0c7b2a0db09e1146a6d00b7eff001283 440 SUPERFAMILY SSF51735 199 436 4.13E-57 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS20350 0c7b2a0db09e1146a6d00b7eff001283 440 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 204 221 1.5E-33 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20350 0c7b2a0db09e1146a6d00b7eff001283 440 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 367 384 1.5E-33 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20350 0c7b2a0db09e1146a6d00b7eff001283 440 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 345 364 1.5E-33 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20350 0c7b2a0db09e1146a6d00b7eff001283 440 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 319 335 1.5E-33 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20350 0c7b2a0db09e1146a6d00b7eff001283 440 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 272 283 1.5E-33 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20350 0c7b2a0db09e1146a6d00b7eff001283 440 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 400 420 1.5E-33 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20350 0c7b2a0db09e1146a6d00b7eff001283 440 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 209 434 5.8E-48 T 09-03-2017 TK78_RS20350 0c7b2a0db09e1146a6d00b7eff001283 440 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 332 360 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS20350 0c7b2a0db09e1146a6d00b7eff001283 440 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 203 377 2.8E-5 T 09-03-2017 TK78_RS22965 d1b693239f1d8750fe659a37ddf0e98b 374 Gene3D G3DSA:3.30.9.10 213 309 1.2E-6 T 09-03-2017 TK78_RS22965 d1b693239f1d8750fe659a37ddf0e98b 374 Gene3D G3DSA:3.30.9.10 82 134 1.2E-6 T 09-03-2017 TK78_RS22965 d1b693239f1d8750fe659a37ddf0e98b 374 TIGRFAM TIGR03364 HpnW_proposed: FAD dependent oxidoreductase TIGR03364 2 366 3.2E-98 T 09-03-2017 IPR017741 FAD-dependent oxidoreductase, HpnW TK78_RS22965 d1b693239f1d8750fe659a37ddf0e98b 374 SUPERFAMILY SSF51905 2 213 2.85E-33 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS22965 d1b693239f1d8750fe659a37ddf0e98b 374 SUPERFAMILY SSF51905 332 372 2.85E-33 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS22965 d1b693239f1d8750fe659a37ddf0e98b 374 Gene3D G3DSA:3.50.50.60 135 212 4.4E-27 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS22965 d1b693239f1d8750fe659a37ddf0e98b 374 Gene3D G3DSA:3.50.50.60 332 371 4.4E-27 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS22965 d1b693239f1d8750fe659a37ddf0e98b 374 Gene3D G3DSA:3.50.50.60 2 78 4.4E-27 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS22965 d1b693239f1d8750fe659a37ddf0e98b 374 Pfam PF01266 FAD dependent oxidoreductase 3 370 5.0E-44 T 09-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 TK78_RS11955 514c933aef9c3e8267354f80c3338ce1 516 ProSitePatterns PS00488 Phenylalanine and histidine ammonia-lyases signature. 141 157 - T 09-03-2017 IPR022313 Phenylalanine/histidine ammonia-lyases, active site GO:0016841 Reactome: R-HSA-70921 TK78_RS11955 514c933aef9c3e8267354f80c3338ce1 516 Gene3D G3DSA:1.10.275.10 3 200 3.4E-72 T 09-03-2017 IPR024083 Fumarase/histidase, N-terminal TK78_RS11955 514c933aef9c3e8267354f80c3338ce1 516 TIGRFAM TIGR01225 hutH: histidine ammonia-lyase 6 509 1.5E-215 T 09-03-2017 IPR005921 Histidine ammonia-lyase GO:0004397|GO:0005737|GO:0006548 KEGG: 00340+4.3.1.3|MetaCyc: PWY-5028|MetaCyc: PWY-5030|Reactome: R-HSA-70921 TK78_RS11955 514c933aef9c3e8267354f80c3338ce1 516 Gene3D G3DSA:1.20.200.10 201 511 5.6E-110 T 09-03-2017 TK78_RS11955 514c933aef9c3e8267354f80c3338ce1 516 Pfam PF00221 Aromatic amino acid lyase 14 475 3.0E-176 T 09-03-2017 IPR001106 Aromatic amino acid lyase Reactome: R-HSA-70921 TK78_RS11955 514c933aef9c3e8267354f80c3338ce1 516 Hamap MF_00229 Histidine ammonia-lyase [hutH]. 5 510 42.859 T 09-03-2017 IPR005921 Histidine ammonia-lyase GO:0004397|GO:0005737|GO:0006548 KEGG: 00340+4.3.1.3|MetaCyc: PWY-5028|MetaCyc: PWY-5030|Reactome: R-HSA-70921 TK78_RS11955 514c933aef9c3e8267354f80c3338ce1 516 SUPERFAMILY SSF48557 5 508 1.49E-171 T 09-03-2017 IPR008948 L-Aspartase-like GO:0003824 TK78_RS10940 ef66d9f3343b19e5b779e7cb4c2f7266 708 Gene3D G3DSA:3.40.50.1820 455 703 2.0E-74 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS10940 ef66d9f3343b19e5b779e7cb4c2f7266 708 Pfam PF00930 Dipeptidyl peptidase IV (DPP IV) N-terminal region 112 409 2.2E-36 T 09-03-2017 IPR002469 Dipeptidylpeptidase IV, N-terminal domain GO:0006508 TK78_RS10940 ef66d9f3343b19e5b779e7cb4c2f7266 708 SUPERFAMILY SSF53474 459 704 7.91E-58 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS10940 ef66d9f3343b19e5b779e7cb4c2f7266 708 Pfam PF00326 Prolyl oligopeptidase family 503 705 1.6E-43 T 09-03-2017 IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain GO:0006508|GO:0008236 TK78_RS10940 ef66d9f3343b19e5b779e7cb4c2f7266 708 ProSitePatterns PS00708 Prolyl endopeptidase family serine active site. 543 573 - T 09-03-2017 IPR002471 Peptidase S9, serine active site GO:0004252|GO:0006508 TK78_RS10940 ef66d9f3343b19e5b779e7cb4c2f7266 708 SUPERFAMILY SSF82171 18 400 2.75E-33 T 09-03-2017 TK78_RS10940 ef66d9f3343b19e5b779e7cb4c2f7266 708 PRINTS PR00862 Prolyl oligopeptidase serine protease (S9A) signature 566 586 1.0E-6 T 09-03-2017 IPR002470 Peptidase S9A, prolyl oligopeptidase GO:0004252|GO:0006508 TK78_RS10940 ef66d9f3343b19e5b779e7cb4c2f7266 708 PRINTS PR00862 Prolyl oligopeptidase serine protease (S9A) signature 509 533 1.0E-6 T 09-03-2017 IPR002470 Peptidase S9A, prolyl oligopeptidase GO:0004252|GO:0006508 TK78_RS10940 ef66d9f3343b19e5b779e7cb4c2f7266 708 PRINTS PR00862 Prolyl oligopeptidase serine protease (S9A) signature 637 659 1.0E-6 T 09-03-2017 IPR002470 Peptidase S9A, prolyl oligopeptidase GO:0004252|GO:0006508 TK78_RS10940 ef66d9f3343b19e5b779e7cb4c2f7266 708 Gene3D G3DSA:2.140.10.30 20 435 1.1E-68 T 09-03-2017 IPR002469 Dipeptidylpeptidase IV, N-terminal domain GO:0006508 TK78_RS05170 52dc3e133434c47e199a0ad4aed61e84 249 Pfam PF00005 ABC transporter 31 159 1.8E-24 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS05170 52dc3e133434c47e199a0ad4aed61e84 249 SMART SM00382 40 209 1.4E-14 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS05170 52dc3e133434c47e199a0ad4aed61e84 249 SUPERFAMILY SSF52540 17 233 4.46E-57 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS05170 52dc3e133434c47e199a0ad4aed61e84 249 Gene3D G3DSA:3.40.50.300 12 211 1.2E-53 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS05170 52dc3e133434c47e199a0ad4aed61e84 249 ProSitePatterns PS00211 ABC transporters family signature. 132 146 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS21915 0da0b09dc0c397f1db99eb8c15ce7f26 342 Pfam PF00535 Glycosyl transferase family 2 10 173 4.7E-21 T 09-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 TK78_RS21915 0da0b09dc0c397f1db99eb8c15ce7f26 342 SUPERFAMILY SSF53448 5 249 3.28E-42 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS21915 0da0b09dc0c397f1db99eb8c15ce7f26 342 Gene3D G3DSA:3.90.550.10 7 239 3.2E-35 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS01945 e50ed659b5856fceb3f57953ecdd2487 238 SUPERFAMILY SSF56214 205 227 8.89E-11 T 09-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 TK78_RS01945 e50ed659b5856fceb3f57953ecdd2487 238 SUPERFAMILY SSF56214 101 174 8.89E-11 T 09-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 TK78_RS01945 e50ed659b5856fceb3f57953ecdd2487 238 Pfam PF01648 4'-phosphopantetheinyl transferase superfamily 102 181 4.3E-7 T 09-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 TK78_RS01945 e50ed659b5856fceb3f57953ecdd2487 238 PRINTS PR01399 Enterobactin synthetase component D signature 146 162 5.4E-23 T 09-03-2017 IPR003542 Enterobactin synthetase-like, component D GO:0009239|GO:0009366|GO:0016780 TK78_RS01945 e50ed659b5856fceb3f57953ecdd2487 238 PRINTS PR01399 Enterobactin synthetase component D signature 68 86 5.4E-23 T 09-03-2017 IPR003542 Enterobactin synthetase-like, component D GO:0009239|GO:0009366|GO:0016780 TK78_RS01945 e50ed659b5856fceb3f57953ecdd2487 238 PRINTS PR01399 Enterobactin synthetase component D signature 38 58 5.4E-23 T 09-03-2017 IPR003542 Enterobactin synthetase-like, component D GO:0009239|GO:0009366|GO:0016780 TK78_RS04780 5b60f4861d758d368e33dd61f6e9b517 217 Pfam PF13483 Beta-lactamase superfamily domain 10 182 1.2E-19 T 09-03-2017 TK78_RS04780 5b60f4861d758d368e33dd61f6e9b517 217 SUPERFAMILY SSF56281 5 187 4.62E-18 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS04780 5b60f4861d758d368e33dd61f6e9b517 217 Gene3D G3DSA:3.60.15.10 3 184 1.3E-24 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS04780 5b60f4861d758d368e33dd61f6e9b517 217 SMART SM00849 14 182 0.0071 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS10480 93902e5834885ef6a98d30ae80af2cb9 483 SMART SM01060 7 391 2.0E-281 T 09-03-2017 IPR011614 Catalase core domain GO:0004096|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS10480 93902e5834885ef6a98d30ae80af2cb9 483 PIRSF PIRSF038928 1 482 1.9E-218 T 09-03-2017 IPR024711 Catalase, mono-functional, haem-containing, clades 1 and 3 GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS10480 93902e5834885ef6a98d30ae80af2cb9 483 ProSitePatterns PS00437 Catalase proximal heme-ligand signature. 333 341 - T 09-03-2017 IPR002226 Catalase haem-binding site GO:0020037 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS10480 93902e5834885ef6a98d30ae80af2cb9 483 Gene3D G3DSA:2.40.180.10 4 357 4.0E-180 T 09-03-2017 IPR011614 Catalase core domain GO:0004096|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS10480 93902e5834885ef6a98d30ae80af2cb9 483 PRINTS PR00067 Catalase signature 20 43 1.1E-68 T 09-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS10480 93902e5834885ef6a98d30ae80af2cb9 483 PRINTS PR00067 Catalase signature 288 315 1.1E-68 T 09-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS10480 93902e5834885ef6a98d30ae80af2cb9 483 PRINTS PR00067 Catalase signature 123 141 1.1E-68 T 09-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS10480 93902e5834885ef6a98d30ae80af2cb9 483 PRINTS PR00067 Catalase signature 104 121 1.1E-68 T 09-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS10480 93902e5834885ef6a98d30ae80af2cb9 483 PRINTS PR00067 Catalase signature 83 101 1.1E-68 T 09-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS10480 93902e5834885ef6a98d30ae80af2cb9 483 PRINTS PR00067 Catalase signature 320 346 1.1E-68 T 09-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS10480 93902e5834885ef6a98d30ae80af2cb9 483 ProSitePatterns PS00438 Catalase proximal active site signature. 43 59 - T 09-03-2017 IPR024708 Catalase active site GO:0004096 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS10480 93902e5834885ef6a98d30ae80af2cb9 483 Pfam PF00199 Catalase 7 388 2.3E-187 T 09-03-2017 IPR011614 Catalase core domain GO:0004096|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS10480 93902e5834885ef6a98d30ae80af2cb9 483 Pfam PF06628 Catalase-related immune-responsive 418 478 1.8E-18 T 09-03-2017 IPR010582 Catalase immune-responsive domain KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS10480 93902e5834885ef6a98d30ae80af2cb9 483 SUPERFAMILY SSF56634 5 479 3.53E-204 T 09-03-2017 IPR020835 Catalase-like domain GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 TK78_RS01215 a3ebd70ca859ac06fd6ed3d229ee2acf 314 SUPERFAMILY SSF53613 17 311 2.81E-54 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS01215 a3ebd70ca859ac06fd6ed3d229ee2acf 314 Pfam PF00294 pfkB family carbohydrate kinase 17 308 4.0E-44 T 09-03-2017 IPR011611 Carbohydrate kinase PfkB TK78_RS01215 a3ebd70ca859ac06fd6ed3d229ee2acf 314 ProSitePatterns PS00584 pfkB family of carbohydrate kinases signature 2. 255 268 - T 09-03-2017 IPR002173 Carbohydrate/puine kinase, PfkB, conserved site GO:0016773 TK78_RS01215 a3ebd70ca859ac06fd6ed3d229ee2acf 314 Gene3D G3DSA:3.40.1190.20 14 311 1.8E-57 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS01215 a3ebd70ca859ac06fd6ed3d229ee2acf 314 ProSitePatterns PS00583 pfkB family of carbohydrate kinases signature 1. 43 67 - T 09-03-2017 IPR002173 Carbohydrate/puine kinase, PfkB, conserved site GO:0016773 TK78_RS21565 c38d817023c547c78a0fe655c89cb885 351 Pfam PF06737 Transglycosylase-like domain 41 116 3.0E-33 T 09-03-2017 IPR010618 Transglycosylase-like TK78_RS21565 c38d817023c547c78a0fe655c89cb885 351 SMART SM00257 275 324 2.2E-5 T 09-03-2017 IPR018392 LysM domain TK78_RS21565 c38d817023c547c78a0fe655c89cb885 351 Pfam PF01476 LysM domain 276 321 6.1E-5 T 09-03-2017 IPR018392 LysM domain TK78_RS21565 c38d817023c547c78a0fe655c89cb885 351 Gene3D G3DSA:1.10.530.10 17 122 6.7E-41 T 09-03-2017 TK78_RS21565 c38d817023c547c78a0fe655c89cb885 351 Gene3D G3DSA:3.10.350.10 276 322 1.1E-6 T 09-03-2017 IPR018392 LysM domain TK78_RS21565 c38d817023c547c78a0fe655c89cb885 351 SUPERFAMILY SSF53955 41 122 1.55E-28 T 09-03-2017 IPR023346 Lysozyme-like domain TK78_RS21565 c38d817023c547c78a0fe655c89cb885 351 SUPERFAMILY SSF54106 275 323 4.45E-5 T 09-03-2017 IPR018392 LysM domain TK78_RS17725 2430a7c0a7f6b6c03fc6c3c044791f40 326 Gene3D G3DSA:3.40.50.920 200 320 1.6E-43 T 09-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 TK78_RS17725 2430a7c0a7f6b6c03fc6c3c044791f40 326 SUPERFAMILY SSF52922 192 324 3.53E-39 T 09-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 TK78_RS17725 2430a7c0a7f6b6c03fc6c3c044791f40 326 Pfam PF02780 Transketolase, C-terminal domain 196 315 1.0E-38 T 09-03-2017 IPR033248 Transketolase, C-terminal domain TK78_RS17725 2430a7c0a7f6b6c03fc6c3c044791f40 326 SMART SM00861 6 181 2.1E-68 T 09-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain TK78_RS17725 2430a7c0a7f6b6c03fc6c3c044791f40 326 Pfam PF02779 Transketolase, pyrimidine binding domain 5 179 3.4E-47 T 09-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain TK78_RS17725 2430a7c0a7f6b6c03fc6c3c044791f40 326 SUPERFAMILY SSF52518 5 187 8.34E-68 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS17725 2430a7c0a7f6b6c03fc6c3c044791f40 326 Gene3D G3DSA:3.40.50.970 4 197 2.6E-75 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS29165 a9db2391dbf34eaf085d607e99f4462c 361 Gene3D G3DSA:3.90.180.10 2 182 2.8E-55 T 09-03-2017 IPR011032 GroES-like TK78_RS29165 a9db2391dbf34eaf085d607e99f4462c 361 SUPERFAMILY SSF50129 310 361 2.59E-7 T 09-03-2017 IPR011032 GroES-like TK78_RS29165 a9db2391dbf34eaf085d607e99f4462c 361 SUPERFAMILY SSF50129 4 186 1.19E-56 T 09-03-2017 IPR011032 GroES-like TK78_RS29165 a9db2391dbf34eaf085d607e99f4462c 361 TIGRFAM TIGR03451 mycoS_dep_FDH: S-(hydroxymethyl)mycothiol dehydrogenase 5 361 2.2E-209 T 09-03-2017 IPR017816 S-(hydroxymethyl)mycothiol dehydrogenase KEGG: 00072+1.1.1.30|KEGG: 00650+1.1.1.30 TK78_RS29165 a9db2391dbf34eaf085d607e99f4462c 361 Pfam PF00107 Zinc-binding dehydrogenase 190 316 9.2E-32 T 09-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 TK78_RS29165 a9db2391dbf34eaf085d607e99f4462c 361 Gene3D G3DSA:3.40.50.720 183 302 5.8E-44 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS29165 a9db2391dbf34eaf085d607e99f4462c 361 SMART SM00829 12 359 1.5E-4 T 09-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 TK78_RS29165 a9db2391dbf34eaf085d607e99f4462c 361 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 29 147 9.5E-27 T 09-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 TK78_RS29165 a9db2391dbf34eaf085d607e99f4462c 361 SUPERFAMILY SSF51735 154 326 1.47E-45 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS29165 a9db2391dbf34eaf085d607e99f4462c 361 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 62 76 - T 09-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 TK78_RS22635 062efdbd3f5101677f92bc68e8b1b59c 250 Pfam PF12706 Beta-lactamase superfamily domain 30 218 8.3E-24 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS22635 062efdbd3f5101677f92bc68e8b1b59c 250 Gene3D G3DSA:3.60.15.10 1 249 5.6E-60 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS22635 062efdbd3f5101677f92bc68e8b1b59c 250 SUPERFAMILY SSF56281 1 250 6.03E-56 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS22635 062efdbd3f5101677f92bc68e8b1b59c 250 SMART SM00849 18 199 1.9E-5 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS22015 57d05748510459cb392e083fc31a8339 328 Pfam PF01545 Cation efflux family 11 218 9.2E-34 T 09-03-2017 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 TK78_RS22015 57d05748510459cb392e083fc31a8339 328 Gene3D G3DSA:1.20.1510.10 8 218 2.9E-35 T 09-03-2017 IPR027469 Cation efflux protein transmembrane domain TK78_RS22015 57d05748510459cb392e083fc31a8339 328 Gene3D G3DSA:3.30.70.1350 224 298 1.4E-6 T 09-03-2017 IPR027470 Cation efflux protein, cytoplasmic domain TK78_RS22015 57d05748510459cb392e083fc31a8339 328 SUPERFAMILY SSF160240 225 295 1.83E-8 T 09-03-2017 TK78_RS22015 57d05748510459cb392e083fc31a8339 328 TIGRFAM TIGR01297 CDF: cation diffusion facilitator family transporter 8 288 1.3E-41 T 09-03-2017 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 TK78_RS22015 57d05748510459cb392e083fc31a8339 328 SUPERFAMILY SSF161111 6 219 6.02E-40 T 09-03-2017 TK78_RS05215 865058aca6893cbafd91f3c94e242f85 152 Pfam PF04075 Domain of unknown function (DUF385) 23 149 9.6E-41 T 09-03-2017 IPR004378 Deazaflavin-dependent nitroreductase/F420H(2)-dependent quinone reductase GO:0016491|GO:0055114 TK78_RS05215 865058aca6893cbafd91f3c94e242f85 152 Gene3D G3DSA:2.30.110.10 52 150 5.6E-4 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS05215 865058aca6893cbafd91f3c94e242f85 152 TIGRFAM TIGR00026 hi_GC_TIGR00026: deazaflavin-dependent oxidoreductase, nitroreductase family 43 150 8.3E-33 T 09-03-2017 IPR004378 Deazaflavin-dependent nitroreductase/F420H(2)-dependent quinone reductase GO:0016491|GO:0055114 TK78_RS22620 49a3633062f4a7349ddd06f2a5308cda 95 Pfam PF02597 ThiS family 5 93 2.1E-18 T 09-03-2017 IPR003749 ThiamineS/Molybdopterin converting factor subunit 1 Reactome: R-HSA-947581 TK78_RS22620 49a3633062f4a7349ddd06f2a5308cda 95 Gene3D G3DSA:3.10.20.30 3 91 2.4E-29 T 09-03-2017 IPR012675 Beta-grasp domain TK78_RS22620 49a3633062f4a7349ddd06f2a5308cda 95 SUPERFAMILY SSF54285 1 93 6.38E-25 T 09-03-2017 IPR016155 Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp TK78_RS34855 b24d05158fa54aabbdcf7a7c20135a8e 370 SUPERFAMILY SSF56349 19 123 9.12E-36 T 09-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 TK78_RS34855 b24d05158fa54aabbdcf7a7c20135a8e 370 SUPERFAMILY SSF56349 152 360 9.12E-36 T 09-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 TK78_RS34855 b24d05158fa54aabbdcf7a7c20135a8e 370 Pfam PF00589 Phage integrase family 163 353 6.0E-27 T 09-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 TK78_RS34855 b24d05158fa54aabbdcf7a7c20135a8e 370 Gene3D G3DSA:1.10.443.10 163 360 7.1E-36 T 09-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 TK78_RS34855 b24d05158fa54aabbdcf7a7c20135a8e 370 Gene3D G3DSA:1.10.150.130 19 117 5.4E-7 T 09-03-2017 IPR023109 Integrase/recombinase, N-terminal TK78_RS00020 b24d05158fa54aabbdcf7a7c20135a8e 370 SUPERFAMILY SSF56349 19 123 9.12E-36 T 09-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 TK78_RS00020 b24d05158fa54aabbdcf7a7c20135a8e 370 SUPERFAMILY SSF56349 152 360 9.12E-36 T 09-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 TK78_RS00020 b24d05158fa54aabbdcf7a7c20135a8e 370 Pfam PF00589 Phage integrase family 163 353 6.0E-27 T 09-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 TK78_RS00020 b24d05158fa54aabbdcf7a7c20135a8e 370 Gene3D G3DSA:1.10.443.10 163 360 7.1E-36 T 09-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 TK78_RS00020 b24d05158fa54aabbdcf7a7c20135a8e 370 Gene3D G3DSA:1.10.150.130 19 117 5.4E-7 T 09-03-2017 IPR023109 Integrase/recombinase, N-terminal TK78_RS32545 c62fd82a8d73d7d2f6f6203835e3f736 312 PRINTS PR00169 Potassium channel signature 19 47 3.8E-6 T 09-03-2017 IPR028325 Voltage-gated potassium channel GO:0005249|GO:0006813|GO:0008076 Reactome: R-HSA-1296072 TK78_RS32545 c62fd82a8d73d7d2f6f6203835e3f736 312 PRINTS PR00169 Potassium channel signature 178 200 3.8E-6 T 09-03-2017 IPR028325 Voltage-gated potassium channel GO:0005249|GO:0006813|GO:0008076 Reactome: R-HSA-1296072 TK78_RS32545 c62fd82a8d73d7d2f6f6203835e3f736 312 PRINTS PR00169 Potassium channel signature 61 84 3.8E-6 T 09-03-2017 IPR028325 Voltage-gated potassium channel GO:0005249|GO:0006813|GO:0008076 Reactome: R-HSA-1296072 TK78_RS32545 c62fd82a8d73d7d2f6f6203835e3f736 312 PRINTS PR00169 Potassium channel signature 88 108 3.8E-6 T 09-03-2017 IPR028325 Voltage-gated potassium channel GO:0005249|GO:0006813|GO:0008076 Reactome: R-HSA-1296072 TK78_RS32545 c62fd82a8d73d7d2f6f6203835e3f736 312 Pfam PF00520 Ion transport protein 26 244 2.7E-41 T 09-03-2017 IPR005821 Ion transport domain GO:0005216|GO:0006811|GO:0016020|GO:0055085 TK78_RS32545 c62fd82a8d73d7d2f6f6203835e3f736 312 Gene3D G3DSA:1.20.120.350 19 129 8.5E-15 T 09-03-2017 IPR027359 Voltage-dependent channel, four helix bundle domain TK78_RS32545 c62fd82a8d73d7d2f6f6203835e3f736 312 SUPERFAMILY SSF81324 25 238 1.67E-29 T 09-03-2017 TK78_RS28350 6ea61bc50aaa7bdc45fc95edd2e09fa0 1029 Gene3D G3DSA:3.80.10.10 799 1003 6.6E-11 T 09-03-2017 IPR032675 Leucine-rich repeat domain, L domain-like TK78_RS28350 6ea61bc50aaa7bdc45fc95edd2e09fa0 1029 SUPERFAMILY SSF52058 780 1005 4.08E-13 T 09-03-2017 IPR032675 Leucine-rich repeat domain, L domain-like TK78_RS28350 6ea61bc50aaa7bdc45fc95edd2e09fa0 1029 SUPERFAMILY SSF52540 239 379 7.29E-7 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28350 6ea61bc50aaa7bdc45fc95edd2e09fa0 1029 Pfam PF05729 NACHT domain 248 409 1.3E-23 T 09-03-2017 TK78_RS28350 6ea61bc50aaa7bdc45fc95edd2e09fa0 1029 Gene3D G3DSA:3.40.50.300 416 501 2.7E-4 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28350 6ea61bc50aaa7bdc45fc95edd2e09fa0 1029 Gene3D G3DSA:3.40.50.300 244 271 2.7E-4 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS05895 aecbb435b4f50cfbb6b2dbd5c13af546 487 Pfam PF01593 Flavin containing amine oxidoreductase 22 467 2.0E-44 T 09-03-2017 IPR002937 Amine oxidase GO:0016491|GO:0055114 TK78_RS05895 aecbb435b4f50cfbb6b2dbd5c13af546 487 SUPERFAMILY SSF54373 306 419 5.49E-26 T 09-03-2017 TK78_RS05895 aecbb435b4f50cfbb6b2dbd5c13af546 487 TIGRFAM TIGR00562 proto_IX_ox: protoporphyrinogen oxidase 14 468 6.0E-65 T 09-03-2017 IPR004572 Protoporphyrinogen oxidase GO:0004729|GO:0006779|GO:0055114 KEGG: 00860+1.3.3.4|MetaCyc: PWY-7159|Reactome: R-HSA-189451 TK78_RS05895 aecbb435b4f50cfbb6b2dbd5c13af546 487 SUPERFAMILY SSF51905 436 468 6.15E-54 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS05895 aecbb435b4f50cfbb6b2dbd5c13af546 487 SUPERFAMILY SSF51905 14 322 6.15E-54 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS05895 aecbb435b4f50cfbb6b2dbd5c13af546 487 Gene3D G3DSA:3.40.50.720 12 55 3.6E-12 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS05895 aecbb435b4f50cfbb6b2dbd5c13af546 487 Gene3D G3DSA:3.90.660.20 243 419 3.3E-32 T 09-03-2017 IPR027418 Protoporphyrinogen oxidase, C-terminal domain KEGG: 00860+1.3.3.4|MetaCyc: PWY-7159|Reactome: R-HSA-189451 TK78_RS05895 aecbb435b4f50cfbb6b2dbd5c13af546 487 Gene3D G3DSA:1.10.3110.10 123 207 1.6E-21 T 09-03-2017 TK78_RS18790 a6e6e20bb71abb3d4ac3740132832efe 221 Gene3D G3DSA:2.80.10.50 68 128 4.0E-7 T 09-03-2017 TK78_RS18790 a6e6e20bb71abb3d4ac3740132832efe 221 SUPERFAMILY SSF50405 106 216 8.24E-12 T 09-03-2017 IPR008999 Actin cross-linking TK78_RS18790 a6e6e20bb71abb3d4ac3740132832efe 221 Gene3D G3DSA:2.80.10.50 129 214 3.3E-7 T 09-03-2017 TK78_RS31665 622cb834ec894225488bd0f6bd7cdbea 241 SUPERFAMILY SSF52317 22 213 7.27E-20 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS31665 622cb834ec894225488bd0f6bd7cdbea 241 Gene3D G3DSA:3.40.50.880 22 212 1.5E-19 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS31665 622cb834ec894225488bd0f6bd7cdbea 241 Pfam PF07685 CobB/CobQ-like glutamine amidotransferase domain 8 201 6.3E-37 T 09-03-2017 IPR011698 CobB/CobQ-like glutamine amidotransferase GO:0003824|GO:0009236 TK78_RS06250 04d0659a66787d5e4a6c85ae2f5b66e3 525 Gene3D G3DSA:3.50.50.60 192 321 1.7E-107 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS06250 04d0659a66787d5e4a6c85ae2f5b66e3 525 Gene3D G3DSA:3.50.50.60 8 130 1.7E-107 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS06250 04d0659a66787d5e4a6c85ae2f5b66e3 525 Gene3D G3DSA:3.50.50.60 453 519 1.7E-107 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS06250 04d0659a66787d5e4a6c85ae2f5b66e3 525 SUPERFAMILY SSF51905 456 519 2.98E-74 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS06250 04d0659a66787d5e4a6c85ae2f5b66e3 525 SUPERFAMILY SSF51905 8 291 2.98E-74 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS06250 04d0659a66787d5e4a6c85ae2f5b66e3 525 Pfam PF05199 GMC oxidoreductase 375 512 2.1E-39 T 09-03-2017 IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal GO:0016614|GO:0055114 Reactome: R-HSA-6798163 TK78_RS06250 04d0659a66787d5e4a6c85ae2f5b66e3 525 ProSitePatterns PS00624 GMC oxidoreductases signature 2. 262 276 - T 09-03-2017 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal GO:0016614|GO:0050660|GO:0055114 Reactome: R-HSA-6798163 TK78_RS06250 04d0659a66787d5e4a6c85ae2f5b66e3 525 Pfam PF00732 GMC oxidoreductase 10 304 1.1E-72 T 09-03-2017 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal GO:0016614|GO:0050660|GO:0055114 Reactome: R-HSA-6798163 TK78_RS06250 04d0659a66787d5e4a6c85ae2f5b66e3 525 SUPERFAMILY SSF54373 298 460 1.37E-45 T 09-03-2017 TK78_RS14400 dd96f77655aecac74b4db8f74e4adbf5 761 Pfam PF01915 Glycosyl hydrolase family 3 C-terminal domain 370 641 4.9E-41 T 09-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 TK78_RS14400 dd96f77655aecac74b4db8f74e4adbf5 761 Gene3D G3DSA:3.40.50.1700 357 643 1.6E-64 T 09-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 TK78_RS14400 dd96f77655aecac74b4db8f74e4adbf5 761 Pfam PF00933 Glycosyl hydrolase family 3 N terminal domain 26 331 2.7E-71 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS14400 dd96f77655aecac74b4db8f74e4adbf5 761 PRINTS PR00133 Glycosyl hydrolase family 3 signature 74 90 1.0E-24 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS14400 dd96f77655aecac74b4db8f74e4adbf5 761 PRINTS PR00133 Glycosyl hydrolase family 3 signature 251 269 1.0E-24 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS14400 dd96f77655aecac74b4db8f74e4adbf5 761 PRINTS PR00133 Glycosyl hydrolase family 3 signature 98 117 1.0E-24 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS14400 dd96f77655aecac74b4db8f74e4adbf5 761 PRINTS PR00133 Glycosyl hydrolase family 3 signature 181 197 1.0E-24 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS14400 dd96f77655aecac74b4db8f74e4adbf5 761 PRINTS PR00133 Glycosyl hydrolase family 3 signature 144 160 1.0E-24 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS14400 dd96f77655aecac74b4db8f74e4adbf5 761 Pfam PF14310 Fibronectin type III-like domain 678 747 1.3E-17 T 09-03-2017 IPR026891 Fibronectin type III-like domain TK78_RS14400 dd96f77655aecac74b4db8f74e4adbf5 761 SUPERFAMILY SSF51445 5 369 5.79E-110 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS14400 dd96f77655aecac74b4db8f74e4adbf5 761 Gene3D G3DSA:3.20.20.300 5 343 4.0E-116 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS14400 dd96f77655aecac74b4db8f74e4adbf5 761 SUPERFAMILY SSF52279 370 463 1.28E-39 T 09-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 TK78_RS14400 dd96f77655aecac74b4db8f74e4adbf5 761 SUPERFAMILY SSF52279 498 643 1.28E-39 T 09-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 TK78_RS14400 dd96f77655aecac74b4db8f74e4adbf5 761 SMART SM01217 678 747 5.2E-25 T 09-03-2017 IPR026891 Fibronectin type III-like domain TK78_RS06930 3e03ca5dd3daca1f7a7fc47ba6bb2b93 266 Gene3D G3DSA:3.30.540.10 6 154 3.4E-46 T 09-03-2017 TK78_RS06930 3e03ca5dd3daca1f7a7fc47ba6bb2b93 266 ProSitePatterns PS00630 Inositol monophosphatase family signature 2. 214 228 - T 09-03-2017 IPR020550 Inositol monophosphatase, conserved site GO:0046854 TK78_RS06930 3e03ca5dd3daca1f7a7fc47ba6bb2b93 266 ProSitePatterns PS00629 Inositol monophosphatase family signature 1. 85 98 - T 09-03-2017 IPR020583 Inositol monophosphatase, metal-binding site TK78_RS06930 3e03ca5dd3daca1f7a7fc47ba6bb2b93 266 Gene3D G3DSA:3.40.190.80 155 260 4.4E-29 T 09-03-2017 TK78_RS06930 3e03ca5dd3daca1f7a7fc47ba6bb2b93 266 Pfam PF00459 Inositol monophosphatase family 6 229 8.9E-55 T 09-03-2017 IPR000760 Inositol monophosphatase GO:0046854 TK78_RS06930 3e03ca5dd3daca1f7a7fc47ba6bb2b93 266 SUPERFAMILY SSF56655 7 260 3.66E-73 T 09-03-2017 TK78_RS06930 3e03ca5dd3daca1f7a7fc47ba6bb2b93 266 PRINTS PR00377 Inositol monophosphatase superfamily signature 134 157 1.5E-41 T 09-03-2017 IPR000760 Inositol monophosphatase GO:0046854 TK78_RS06930 3e03ca5dd3daca1f7a7fc47ba6bb2b93 266 PRINTS PR00377 Inositol monophosphatase superfamily signature 43 63 1.5E-41 T 09-03-2017 IPR000760 Inositol monophosphatase GO:0046854 TK78_RS06930 3e03ca5dd3daca1f7a7fc47ba6bb2b93 266 PRINTS PR00377 Inositol monophosphatase superfamily signature 85 101 1.5E-41 T 09-03-2017 IPR000760 Inositol monophosphatase GO:0046854 TK78_RS06930 3e03ca5dd3daca1f7a7fc47ba6bb2b93 266 PRINTS PR00377 Inositol monophosphatase superfamily signature 180 201 1.5E-41 T 09-03-2017 IPR000760 Inositol monophosphatase GO:0046854 TK78_RS06930 3e03ca5dd3daca1f7a7fc47ba6bb2b93 266 PRINTS PR00377 Inositol monophosphatase superfamily signature 211 235 1.5E-41 T 09-03-2017 IPR000760 Inositol monophosphatase GO:0046854 TK78_RS06930 3e03ca5dd3daca1f7a7fc47ba6bb2b93 266 PRINTS PR00377 Inositol monophosphatase superfamily signature 65 81 1.5E-41 T 09-03-2017 IPR000760 Inositol monophosphatase GO:0046854 TK78_RS16805 7afc1b022baf53b5c7ec772b190959d9 989 Pfam PF03422 Carbohydrate binding module (family 6) 666 793 4.8E-5 T 09-03-2017 IPR005084 Carbohydrate binding module family 6 GO:0030246 TK78_RS16805 7afc1b022baf53b5c7ec772b190959d9 989 SUPERFAMILY SSF49785 663 794 3.52E-21 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS16805 7afc1b022baf53b5c7ec772b190959d9 989 Gene3D G3DSA:2.60.120.260 661 795 1.1E-23 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS16805 7afc1b022baf53b5c7ec772b190959d9 989 Pfam PF07691 PA14 domain 32 169 6.6E-16 T 09-03-2017 IPR011658 PA14 domain TK78_RS16805 7afc1b022baf53b5c7ec772b190959d9 989 SMART SM00758 31 171 5.0E-26 T 09-03-2017 IPR011658 PA14 domain TK78_RS16805 7afc1b022baf53b5c7ec772b190959d9 989 SUPERFAMILY SSF50952 198 520 1.44E-15 T 09-03-2017 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 TK78_RS16805 7afc1b022baf53b5c7ec772b190959d9 989 Gene3D G3DSA:3.90.182.10 62 216 8.5E-21 T 09-03-2017 IPR011658 PA14 domain TK78_RS16805 7afc1b022baf53b5c7ec772b190959d9 989 Pfam PF06439 Domain of Unknown Function (DUF1080) 798 987 8.1E-35 T 09-03-2017 IPR010496 Domain of unknown function DUF1080 TK78_RS16805 7afc1b022baf53b5c7ec772b190959d9 989 Gene3D G3DSA:2.120.10.30 223 405 1.1E-10 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS16805 7afc1b022baf53b5c7ec772b190959d9 989 SUPERFAMILY SSF56988 86 196 1.06E-9 T 09-03-2017 TK78_RS27690 5dceba353407028d6ff67d394d693043 122 SMART SM00028 43 76 64.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS27690 5dceba353407028d6ff67d394d693043 122 SMART SM00028 77 110 0.45 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS27690 5dceba353407028d6ff67d394d693043 122 SUPERFAMILY SSF48452 10 114 1.2E-16 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS27690 5dceba353407028d6ff67d394d693043 122 Pfam PF14559 Tetratricopeptide repeat 19 77 2.8E-7 T 09-03-2017 TK78_RS27690 5dceba353407028d6ff67d394d693043 122 Gene3D G3DSA:1.25.40.10 3 109 2.7E-16 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS25505 521b9616f1a61f14c3bed092fc2ed419 219 SUPERFAMILY SSF52172 2 176 3.15E-35 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS25505 521b9616f1a61f14c3bed092fc2ed419 219 Gene3D G3DSA:3.40.50.2300 2 116 9.2E-34 T 09-03-2017 TK78_RS25505 521b9616f1a61f14c3bed092fc2ed419 219 SMART SM00448 2 113 1.4E-36 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS25505 521b9616f1a61f14c3bed092fc2ed419 219 SMART SM00862 147 218 3.1E-29 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS25505 521b9616f1a61f14c3bed092fc2ed419 219 Pfam PF00072 Response regulator receiver domain 4 114 9.1E-24 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS25505 521b9616f1a61f14c3bed092fc2ed419 219 Gene3D G3DSA:1.10.10.10 127 218 1.4E-32 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS25505 521b9616f1a61f14c3bed092fc2ed419 219 Pfam PF00486 Transcriptional regulatory protein, C terminal 148 218 1.3E-26 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS27315 74ba39a983d8a803c77e5c214be6102a 124 SUPERFAMILY SSF141734 17 121 1.07E-46 T 09-03-2017 TK78_RS27315 74ba39a983d8a803c77e5c214be6102a 124 Hamap MF_01021 Phosphoribosyl-AMP cyclohydrolase [hisI]. 18 121 31.72 T 09-03-2017 IPR026660 Phosphoribosyl-AMP cyclohydrolase GO:0000105|GO:0004635 KEGG: 00340+3.5.4.19 TK78_RS27315 74ba39a983d8a803c77e5c214be6102a 124 ProDom PD002610 PHOSPHORIBOSYL-AMP BIOSYNTHESIS CYCLOHYDROLASE HYDROLASE HISTIDINE AMINO-ACID PRA-CH PHOSPHORIBOSYL-ATP BIFUNCTIONAL INCLUDES: 67 121 3.0E-22 T 09-03-2017 IPR002496 Phosphoribosyl-AMP cyclohydrolase domain GO:0000105|GO:0004635 KEGG: 00340+3.5.4.19 TK78_RS27315 74ba39a983d8a803c77e5c214be6102a 124 Pfam PF01502 Phosphoribosyl-AMP cyclohydrolase 44 116 5.6E-34 T 09-03-2017 IPR002496 Phosphoribosyl-AMP cyclohydrolase domain GO:0000105|GO:0004635 KEGG: 00340+3.5.4.19 TK78_RS24115 13c6b8c936e625a23fc6aa45d0c958df 955 SUPERFAMILY SSF48452 712 816 1.78E-12 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS24115 13c6b8c936e625a23fc6aa45d0c958df 955 Gene3D G3DSA:1.25.40.10 698 831 1.4E-10 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS24115 13c6b8c936e625a23fc6aa45d0c958df 955 Pfam PF16918 Protein kinase G tetratricopeptide repeat 643 953 3.4E-85 T 09-03-2017 IPR031636 Protein kinase G, tetratricopeptide repeat containing domain KEGG: 04150+2.7.11.1|KEGG: 04151+2.7.11.1 TK78_RS24115 13c6b8c936e625a23fc6aa45d0c958df 955 Pfam PF16919 Protein kinase G rubredoxin domain 59 193 1.7E-43 T 09-03-2017 IPR031634 Protein kinase G, rubredoxin domain KEGG: 04150+2.7.11.1|KEGG: 04151+2.7.11.1 TK78_RS24115 13c6b8c936e625a23fc6aa45d0c958df 955 Gene3D G3DSA:3.30.200.20 185 275 9.3E-14 T 09-03-2017 TK78_RS24115 13c6b8c936e625a23fc6aa45d0c958df 955 SUPERFAMILY SSF56112 186 460 2.08E-40 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS24115 13c6b8c936e625a23fc6aa45d0c958df 955 Gene3D G3DSA:1.10.510.10 276 394 2.7E-19 T 09-03-2017 TK78_RS24115 13c6b8c936e625a23fc6aa45d0c958df 955 Pfam PF00069 Protein kinase domain 195 394 1.2E-24 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS31590 6754583f2adb591853998e414ecb48ef 201 Gene3D G3DSA:3.90.226.10 10 200 2.8E-63 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS31590 6754583f2adb591853998e414ecb48ef 201 PRINTS PR00127 Clp protease catalytic subunit P signature 96 113 1.1E-33 T 09-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TK78_RS31590 6754583f2adb591853998e414ecb48ef 201 PRINTS PR00127 Clp protease catalytic subunit P signature 176 195 1.1E-33 T 09-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TK78_RS31590 6754583f2adb591853998e414ecb48ef 201 PRINTS PR00127 Clp protease catalytic subunit P signature 117 136 1.1E-33 T 09-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TK78_RS31590 6754583f2adb591853998e414ecb48ef 201 PRINTS PR00127 Clp protease catalytic subunit P signature 25 40 1.1E-33 T 09-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TK78_RS31590 6754583f2adb591853998e414ecb48ef 201 PRINTS PR00127 Clp protease catalytic subunit P signature 65 85 1.1E-33 T 09-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TK78_RS31590 6754583f2adb591853998e414ecb48ef 201 SUPERFAMILY SSF52096 18 200 4.31E-53 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS31590 6754583f2adb591853998e414ecb48ef 201 Pfam PF00574 Clp protease 20 200 2.1E-63 T 09-03-2017 IPR023562 Clp protease proteolytic subunit /Translocation-enhancing protein TepA TK78_RS31590 6754583f2adb591853998e414ecb48ef 201 Hamap MF_00444 ATP-dependent Clp protease proteolytic subunit [clpP]. 9 201 35.221 T 09-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TK78_RS05940 b6a5d72584fc246c2f3297df89cfbe40 709 SUPERFAMILY SSF48179 522 616 2.55E-16 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS05940 b6a5d72584fc246c2f3297df89cfbe40 709 Gene3D G3DSA:3.40.50.720 334 525 9.1E-54 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS05940 b6a5d72584fc246c2f3297df89cfbe40 709 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 340 520 6.2E-57 T 09-03-2017 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS05940 b6a5d72584fc246c2f3297df89cfbe40 709 Gene3D G3DSA:1.10.1040.10 526 611 7.4E-11 T 09-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 TK78_RS05940 b6a5d72584fc246c2f3297df89cfbe40 709 Pfam PF00378 Enoyl-CoA hydratase/isomerase 52 239 5.3E-19 T 09-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 TK78_RS05940 b6a5d72584fc246c2f3297df89cfbe40 709 SUPERFAMILY SSF52096 253 328 3.17E-34 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS05940 b6a5d72584fc246c2f3297df89cfbe40 709 SUPERFAMILY SSF52096 34 220 3.17E-34 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS05940 b6a5d72584fc246c2f3297df89cfbe40 709 SUPERFAMILY SSF48179 635 695 2.38E-10 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS05940 b6a5d72584fc246c2f3297df89cfbe40 709 SUPERFAMILY SSF51735 338 522 2.67E-52 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS05940 b6a5d72584fc246c2f3297df89cfbe40 709 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 524 605 4.7E-11 T 09-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS05940 b6a5d72584fc246c2f3297df89cfbe40 709 Gene3D G3DSA:3.90.226.10 35 240 1.1E-35 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS15115 96114b6d9bdfb7cfcfaf907ef06452ae 246 ProSitePatterns PS01066 Undecaprenyl pyrophosphate synthase family signature. 183 200 - T 09-03-2017 IPR018520 Di-trans-poly-cis-decaprenylcistransferase-like, conserved site GO:0016765 Reactome: R-HSA-446199|Reactome: R-HSA-4755609 TK78_RS15115 96114b6d9bdfb7cfcfaf907ef06452ae 246 TIGRFAM TIGR00055 uppS: di-trans,poly-cis-decaprenylcistransferase 10 234 1.3E-54 T 09-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TK78_RS15115 96114b6d9bdfb7cfcfaf907ef06452ae 246 Hamap MF_01139 Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) [uppS]. 10 238 30.576 T 09-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TK78_RS15115 96114b6d9bdfb7cfcfaf907ef06452ae 246 SUPERFAMILY SSF64005 7 232 3.27E-63 T 09-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TK78_RS15115 96114b6d9bdfb7cfcfaf907ef06452ae 246 Gene3D G3DSA:3.40.1180.10 5 235 2.6E-73 T 09-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TK78_RS15115 96114b6d9bdfb7cfcfaf907ef06452ae 246 Pfam PF01255 Putative undecaprenyl diphosphate synthase 17 234 4.1E-62 T 09-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TK78_RS29160 1f6545e4845eb7b3cfdeec75e7984499 233 SUPERFAMILY SSF48008 96 222 1.41E-20 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS29160 1f6545e4845eb7b3cfdeec75e7984499 233 SUPERFAMILY SSF46785 4 74 1.66E-16 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS29160 1f6545e4845eb7b3cfdeec75e7984499 233 SMART SM00345 12 70 6.2E-12 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS29160 1f6545e4845eb7b3cfdeec75e7984499 233 SMART SM00895 99 223 1.3E-16 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS29160 1f6545e4845eb7b3cfdeec75e7984499 233 Gene3D G3DSA:1.10.10.10 4 72 2.5E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS29160 1f6545e4845eb7b3cfdeec75e7984499 233 Gene3D G3DSA:1.20.120.530 86 220 1.9E-20 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS29160 1f6545e4845eb7b3cfdeec75e7984499 233 Pfam PF00392 Bacterial regulatory proteins, gntR family 11 70 4.0E-13 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS29160 1f6545e4845eb7b3cfdeec75e7984499 233 Pfam PF07729 FCD domain 100 219 7.4E-21 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS29230 364b5203adb07ead5263fe59d071a529 331 Gene3D G3DSA:1.20.58.340 138 253 2.4E-38 T 09-03-2017 TK78_RS29230 364b5203adb07ead5263fe59d071a529 331 Gene3D G3DSA:3.30.460.20 4 137 3.8E-43 T 09-03-2017 TK78_RS29230 364b5203adb07ead5263fe59d071a529 331 Pfam PF01544 CorA-like Mg2+ transporter protein 35 327 1.4E-63 T 09-03-2017 IPR002523 Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB GO:0016020|GO:0030001|GO:0046873|GO:0055085 TK78_RS29230 364b5203adb07ead5263fe59d071a529 331 TIGRFAM TIGR00383 corA: magnesium and cobalt transport protein CorA 27 331 1.1E-62 T 09-03-2017 IPR004488 Magnesium/cobalt transport protein CorA GO:0006824|GO:0015087|GO:0015095|GO:0015693|GO:0016020 TK78_RS29230 364b5203adb07ead5263fe59d071a529 331 Gene3D G3DSA:1.20.58.340 255 331 7.3E-27 T 09-03-2017 TK78_RS29230 364b5203adb07ead5263fe59d071a529 331 SUPERFAMILY SSF143865 4 263 3.27E-68 T 09-03-2017 TK78_RS29230 364b5203adb07ead5263fe59d071a529 331 SUPERFAMILY SSF144083 266 328 3.79E-20 T 09-03-2017 TK78_RS29130 f87143b3b0c8702df865edfdce758898 553 PIRSF PIRSF036654 1 551 2.3E-289 T 09-03-2017 IPR014614 Uncharacterised conserved protein UCP036654 GO:0016627|GO:0055114 TK78_RS29130 f87143b3b0c8702df865edfdce758898 553 Gene3D G3DSA:3.50.50.60 485 550 1.1E-60 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS29130 f87143b3b0c8702df865edfdce758898 553 Gene3D G3DSA:3.50.50.60 3 275 1.1E-60 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS29130 f87143b3b0c8702df865edfdce758898 553 Pfam PF00890 FAD binding domain 6 533 4.9E-107 T 09-03-2017 IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS29130 f87143b3b0c8702df865edfdce758898 553 SUPERFAMILY SSF51905 483 551 7.29E-30 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS29130 f87143b3b0c8702df865edfdce758898 553 SUPERFAMILY SSF51905 1 272 7.29E-30 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS21795 0bf164568dd92d0c5296e7f0dce5986f 421 Gene3D G3DSA:1.10.287.130 193 263 3.1E-12 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS21795 0bf164568dd92d0c5296e7f0dce5986f 421 SMART SM00387 309 410 5.3E-14 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS21795 0bf164568dd92d0c5296e7f0dce5986f 421 Pfam PF00512 His Kinase A (phospho-acceptor) domain 203 263 1.4E-9 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS21795 0bf164568dd92d0c5296e7f0dce5986f 421 Pfam PF00672 HAMP domain 130 197 3.0E-9 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS21795 0bf164568dd92d0c5296e7f0dce5986f 421 SUPERFAMILY SSF47384 186 263 2.94E-13 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS21795 0bf164568dd92d0c5296e7f0dce5986f 421 SMART SM00388 202 267 7.7E-10 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS21795 0bf164568dd92d0c5296e7f0dce5986f 421 Gene3D G3DSA:3.30.565.10 272 416 3.0E-25 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS21795 0bf164568dd92d0c5296e7f0dce5986f 421 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 313 394 5.0E-8 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS21795 0bf164568dd92d0c5296e7f0dce5986f 421 SUPERFAMILY SSF55874 270 408 4.85E-24 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS21795 0bf164568dd92d0c5296e7f0dce5986f 421 PRINTS PR00344 Bacterial sensor protein C-terminal signature 362 372 5.1E-9 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS21795 0bf164568dd92d0c5296e7f0dce5986f 421 PRINTS PR00344 Bacterial sensor protein C-terminal signature 372 390 5.1E-9 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS21795 0bf164568dd92d0c5296e7f0dce5986f 421 PRINTS PR00344 Bacterial sensor protein C-terminal signature 344 358 5.1E-9 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS00710 777af6bbdf6c3f4a24e4d2405130d05d 374 Gene3D G3DSA:1.10.10.10 3 54 3.8E-13 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS00710 777af6bbdf6c3f4a24e4d2405130d05d 374 Gene3D G3DSA:3.40.50.2300 193 368 1.6E-27 T 09-03-2017 TK78_RS00710 777af6bbdf6c3f4a24e4d2405130d05d 374 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 40 58 1.5E-6 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS00710 777af6bbdf6c3f4a24e4d2405130d05d 374 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 26 40 1.5E-6 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS00710 777af6bbdf6c3f4a24e4d2405130d05d 374 Gene3D G3DSA:3.40.50.2300 80 192 4.9E-18 T 09-03-2017 TK78_RS00710 777af6bbdf6c3f4a24e4d2405130d05d 374 SUPERFAMILY SSF46785 5 61 2.06E-10 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS00710 777af6bbdf6c3f4a24e4d2405130d05d 374 SUPERFAMILY SSF53822 79 337 1.33E-32 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS00710 777af6bbdf6c3f4a24e4d2405130d05d 374 Pfam PF08220 DeoR-like helix-turn-helix domain 8 61 2.0E-14 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS00710 777af6bbdf6c3f4a24e4d2405130d05d 374 SMART SM00420 8 60 1.4E-12 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS00710 777af6bbdf6c3f4a24e4d2405130d05d 374 ProSitePatterns PS00894 DeoR-type HTH domain signature. 8 42 - T 09-03-2017 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 TK78_RS00710 777af6bbdf6c3f4a24e4d2405130d05d 374 Pfam PF13377 Periplasmic binding protein-like domain 193 367 4.4E-27 T 09-03-2017 TK78_RS19810 4dddb9d5720ec1a8428927d2d6ab4682 1079 Gene3D G3DSA:3.80.10.10 852 1007 7.5E-9 T 09-03-2017 IPR032675 Leucine-rich repeat domain, L domain-like TK78_RS19810 4dddb9d5720ec1a8428927d2d6ab4682 1079 Gene3D G3DSA:2.40.10.10 17 83 1.5E-6 T 09-03-2017 TK78_RS19810 4dddb9d5720ec1a8428927d2d6ab4682 1079 Pfam PF13365 Trypsin-like peptidase domain 19 159 4.7E-8 T 09-03-2017 TK78_RS19810 4dddb9d5720ec1a8428927d2d6ab4682 1079 Pfam PF05729 NACHT domain 286 447 1.1E-22 T 09-03-2017 TK78_RS19810 4dddb9d5720ec1a8428927d2d6ab4682 1079 SUPERFAMILY SSF52058 810 993 3.51E-9 T 09-03-2017 IPR032675 Leucine-rich repeat domain, L domain-like TK78_RS19810 4dddb9d5720ec1a8428927d2d6ab4682 1079 SUPERFAMILY SSF50494 16 172 6.06E-16 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS19810 4dddb9d5720ec1a8428927d2d6ab4682 1079 SUPERFAMILY SSF52540 275 415 1.49E-8 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22460 18e9ea66f2ba64e19885b6961f6ffb2b 501 Gene3D G3DSA:1.20.1250.20 51 223 5.0E-23 T 09-03-2017 TK78_RS22460 18e9ea66f2ba64e19885b6961f6ffb2b 501 Gene3D G3DSA:1.20.1250.20 299 496 2.9E-7 T 09-03-2017 TK78_RS22460 18e9ea66f2ba64e19885b6961f6ffb2b 501 SUPERFAMILY SSF103473 277 497 4.05E-37 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS22460 18e9ea66f2ba64e19885b6961f6ffb2b 501 SUPERFAMILY SSF103473 30 229 4.05E-37 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS22460 18e9ea66f2ba64e19885b6961f6ffb2b 501 Pfam PF07690 Major Facilitator Superfamily 53 438 7.9E-34 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS12695 4628adcb8e55a2d9e12567a664b626cf 420 PIRSF PIRSF000124 3 419 3.3E-49 T 09-03-2017 IPR017476 UDP-glucose/GDP-mannose dehydrogenase GO:0016616|GO:0055114 Reactome: R-HSA-173599 TK78_RS12695 4628adcb8e55a2d9e12567a664b626cf 420 SUPERFAMILY SSF52413 306 413 1.1E-21 T 09-03-2017 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 TK78_RS12695 4628adcb8e55a2d9e12567a664b626cf 420 Gene3D G3DSA:3.40.50.720 232 412 1.4E-36 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS12695 4628adcb8e55a2d9e12567a664b626cf 420 ProSitePatterns PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 5 32 - T 09-03-2017 IPR029752 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 TK78_RS12695 4628adcb8e55a2d9e12567a664b626cf 420 Gene3D G3DSA:3.40.50.720 4 222 5.7E-41 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS12695 4628adcb8e55a2d9e12567a664b626cf 420 Pfam PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 201 292 4.7E-22 T 09-03-2017 IPR014026 UDP-glucose/GDP-mannose dehydrogenase, dimerisation GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 TK78_RS12695 4628adcb8e55a2d9e12567a664b626cf 420 TIGRFAM TIGR03026 NDP-sugDHase: nucleotide sugar dehydrogenase 4 409 2.1E-103 T 09-03-2017 IPR017476 UDP-glucose/GDP-mannose dehydrogenase GO:0016616|GO:0055114 Reactome: R-HSA-173599 TK78_RS12695 4628adcb8e55a2d9e12567a664b626cf 420 Pfam PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 5 183 6.4E-28 T 09-03-2017 IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 TK78_RS12695 4628adcb8e55a2d9e12567a664b626cf 420 SUPERFAMILY SSF51735 6 195 3.94E-34 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS12695 4628adcb8e55a2d9e12567a664b626cf 420 SMART SM00984 319 414 9.3E-19 T 09-03-2017 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 TK78_RS12695 4628adcb8e55a2d9e12567a664b626cf 420 Pfam PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 320 411 8.1E-16 T 09-03-2017 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 TK78_RS12695 4628adcb8e55a2d9e12567a664b626cf 420 SUPERFAMILY SSF48179 201 298 6.97E-24 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS12695 4628adcb8e55a2d9e12567a664b626cf 420 PIRSF PIRSF500136 1 420 3.5E-127 T 09-03-2017 IPR028359 UDP-N-acetyl-D-mannosamine/glucosamine dehydrogenase GO:0000271|GO:0016628|GO:0055114 TK78_RS13610 0b7bd86530cfbc5c5fc700fa60840c37 631 TIGRFAM TIGR01974 NDH_I_L: proton-translocating NADH-quinone oxidoreductase, chain L 3 625 3.2E-238 T 09-03-2017 IPR003945 NADH-plastoquinone oxidoreductase, chain 5 GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13610 0b7bd86530cfbc5c5fc700fa60840c37 631 Pfam PF00662 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus 66 123 6.4E-25 T 09-03-2017 IPR001516 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13610 0b7bd86530cfbc5c5fc700fa60840c37 631 Pfam PF00361 Proton-conducting membrane transporter 135 419 5.4E-82 T 09-03-2017 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13610 0b7bd86530cfbc5c5fc700fa60840c37 631 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 112 132 1.7E-60 T 09-03-2017 TK78_RS13610 0b7bd86530cfbc5c5fc700fa60840c37 631 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 421 440 1.7E-60 T 09-03-2017 TK78_RS13610 0b7bd86530cfbc5c5fc700fa60840c37 631 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 159 180 1.7E-60 T 09-03-2017 TK78_RS13610 0b7bd86530cfbc5c5fc700fa60840c37 631 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 246 272 1.7E-60 T 09-03-2017 TK78_RS13610 0b7bd86530cfbc5c5fc700fa60840c37 631 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 224 245 1.7E-60 T 09-03-2017 TK78_RS13610 0b7bd86530cfbc5c5fc700fa60840c37 631 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 314 326 1.7E-60 T 09-03-2017 TK78_RS13610 0b7bd86530cfbc5c5fc700fa60840c37 631 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 84 109 1.7E-60 T 09-03-2017 TK78_RS13610 0b7bd86530cfbc5c5fc700fa60840c37 631 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 420 442 5.7E-12 T 09-03-2017 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 TK78_RS13610 0b7bd86530cfbc5c5fc700fa60840c37 631 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 264 286 5.7E-12 T 09-03-2017 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 TK78_RS13610 0b7bd86530cfbc5c5fc700fa60840c37 631 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 60 84 5.7E-12 T 09-03-2017 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 TK78_RS13610 0b7bd86530cfbc5c5fc700fa60840c37 631 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 86 106 5.7E-12 T 09-03-2017 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 TK78_RS05975 d7f3294a99ae1403d58852f05d07ab80 359 TIGRFAM TIGR00350 lytR_cpsA_psr: cell envelope-related function transcriptional attenuator common domain 104 261 6.4E-58 T 09-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain TK78_RS05975 d7f3294a99ae1403d58852f05d07ab80 359 Pfam PF03816 Cell envelope-related transcriptional attenuator domain 105 261 5.5E-48 T 09-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain TK78_RS19140 36d2041626467755c628d8df67301c20 378 Pfam PF03459 TOBE domain 309 367 2.7E-5 T 09-03-2017 IPR005116 Transport-associated OB, type 1 TK78_RS19140 36d2041626467755c628d8df67301c20 378 ProSitePatterns PS00211 ABC transporters family signature. 136 150 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS19140 36d2041626467755c628d8df67301c20 378 Gene3D G3DSA:2.40.50.140 285 359 7.5E-8 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS19140 36d2041626467755c628d8df67301c20 378 SUPERFAMILY SSF52540 6 245 5.79E-83 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS19140 36d2041626467755c628d8df67301c20 378 SMART SM00382 30 213 2.2E-12 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS19140 36d2041626467755c628d8df67301c20 378 Pfam PF00005 ABC transporter 22 163 6.5E-30 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS19140 36d2041626467755c628d8df67301c20 378 Gene3D G3DSA:3.40.50.300 4 236 9.4E-72 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS19140 36d2041626467755c628d8df67301c20 378 SUPERFAMILY SSF50331 238 376 2.32E-20 T 09-03-2017 IPR008995 Molybdate/tungstate binding, C-terminal TK78_RS19140 36d2041626467755c628d8df67301c20 378 Gene3D G3DSA:2.40.50.100 241 284 5.7E-8 T 09-03-2017 TK78_RS19140 36d2041626467755c628d8df67301c20 378 Gene3D G3DSA:2.40.50.100 362 376 5.7E-8 T 09-03-2017 TK78_RS02685 3ad610ad6e6a0272fad0aa21252bf9fe 671 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 498 516 7.8E-12 T 09-03-2017 TK78_RS02685 3ad610ad6e6a0272fad0aa21252bf9fe 671 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 378 397 7.8E-12 T 09-03-2017 TK78_RS02685 3ad610ad6e6a0272fad0aa21252bf9fe 671 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 617 633 7.8E-12 T 09-03-2017 TK78_RS02685 3ad610ad6e6a0272fad0aa21252bf9fe 671 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 618 632 1.9E-5 T 09-03-2017 TK78_RS02685 3ad610ad6e6a0272fad0aa21252bf9fe 671 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 377 399 1.9E-5 T 09-03-2017 TK78_RS02685 3ad610ad6e6a0272fad0aa21252bf9fe 671 SUPERFAMILY SSF51395 2 367 1.75E-112 T 09-03-2017 TK78_RS02685 3ad610ad6e6a0272fad0aa21252bf9fe 671 SUPERFAMILY SSF51905 461 519 1.35E-24 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS02685 3ad610ad6e6a0272fad0aa21252bf9fe 671 SUPERFAMILY SSF51905 555 649 1.35E-24 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS02685 3ad610ad6e6a0272fad0aa21252bf9fe 671 Pfam PF00724 NADH:flavin oxidoreductase / NADH oxidase family 7 331 2.0E-87 T 09-03-2017 IPR001155 NADH:flavin oxidoreductase/NADH oxidase, N-terminal GO:0010181|GO:0016491|GO:0055114 TK78_RS02685 3ad610ad6e6a0272fad0aa21252bf9fe 671 SUPERFAMILY SSF51971 334 519 4.59E-42 T 09-03-2017 TK78_RS02685 3ad610ad6e6a0272fad0aa21252bf9fe 671 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 376 643 1.9E-27 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS02685 3ad610ad6e6a0272fad0aa21252bf9fe 671 Gene3D G3DSA:3.20.20.70 4 360 3.6E-123 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS02685 3ad610ad6e6a0272fad0aa21252bf9fe 671 Gene3D G3DSA:3.50.50.60 361 465 4.7E-26 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS02685 3ad610ad6e6a0272fad0aa21252bf9fe 671 Gene3D G3DSA:3.50.50.60 470 624 3.8E-51 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS00775 0945c8ab9cedcc711f95038032eb2452 570 Pfam PF00005 ABC transporter 317 474 2.2E-22 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS00775 0945c8ab9cedcc711f95038032eb2452 570 SUPERFAMILY SSF52540 295 546 7.59E-61 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS00775 0945c8ab9cedcc711f95038032eb2452 570 Gene3D G3DSA:1.10.3720.10 58 262 4.8E-21 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS00775 0945c8ab9cedcc711f95038032eb2452 570 SMART SM00382 325 532 5.6E-12 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS00775 0945c8ab9cedcc711f95038032eb2452 570 SUPERFAMILY SSF161098 61 243 1.1E-20 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS00775 0945c8ab9cedcc711f95038032eb2452 570 Gene3D G3DSA:3.40.50.300 294 548 2.6E-71 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS00775 0945c8ab9cedcc711f95038032eb2452 570 ProSitePatterns PS00211 ABC transporters family signature. 447 461 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS00775 0945c8ab9cedcc711f95038032eb2452 570 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 84 264 1.1E-15 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS19640 27d0dbb1ed86c7f5d5df8d863af75b45 201 Pfam PF01227 GTP cyclohydrolase I 22 198 1.6E-74 T 09-03-2017 IPR020602 GTP cyclohydrolase I domain KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|Reactome: R-HSA-1474151 TK78_RS19640 27d0dbb1ed86c7f5d5df8d863af75b45 201 SUPERFAMILY SSF55620 12 198 1.26E-74 T 09-03-2017 TK78_RS19640 27d0dbb1ed86c7f5d5df8d863af75b45 201 Hamap MF_00223 GTP cyclohydrolase 1 [folE]. 17 199 41.4 T 09-03-2017 IPR001474 GTP cyclohydrolase I GO:0003934|GO:0005737|GO:0046654 KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|Reactome: R-HSA-1474151 TK78_RS19640 27d0dbb1ed86c7f5d5df8d863af75b45 201 Gene3D G3DSA:3.30.1130.10 70 198 1.3E-56 T 09-03-2017 TK78_RS19640 27d0dbb1ed86c7f5d5df8d863af75b45 201 Gene3D G3DSA:1.10.286.10 16 67 1.1E-23 T 09-03-2017 TK78_RS19640 27d0dbb1ed86c7f5d5df8d863af75b45 201 ProSitePatterns PS00860 GTP cyclohydrolase I signature 2. 127 137 - T 09-03-2017 IPR018234 GTP cyclohydrolase I, conserved site GO:0003934|GO:0005737|GO:0046654 KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|Reactome: R-HSA-1474151 TK78_RS19640 27d0dbb1ed86c7f5d5df8d863af75b45 201 TIGRFAM TIGR00063 folE: GTP cyclohydrolase I 23 198 6.2E-70 T 09-03-2017 IPR001474 GTP cyclohydrolase I GO:0003934|GO:0005737|GO:0046654 KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|Reactome: R-HSA-1474151 TK78_RS19640 27d0dbb1ed86c7f5d5df8d863af75b45 201 ProSitePatterns PS00859 GTP cyclohydrolase I signature 1. 77 93 - T 09-03-2017 IPR018234 GTP cyclohydrolase I, conserved site GO:0003934|GO:0005737|GO:0046654 KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|Reactome: R-HSA-1474151 TK78_RS16840 3642419af68008b79b545a07035339a0 487 Gene3D G3DSA:3.40.50.620 175 413 3.4E-12 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS16840 3642419af68008b79b545a07035339a0 487 Pfam PF00733 Asparagine synthase 177 321 2.5E-6 T 09-03-2017 IPR001962 Asparagine synthase GO:0004066|GO:0006529 TK78_RS16840 3642419af68008b79b545a07035339a0 487 SUPERFAMILY SSF52402 360 453 1.88E-16 T 09-03-2017 TK78_RS16840 3642419af68008b79b545a07035339a0 487 SUPERFAMILY SSF52402 175 314 1.88E-16 T 09-03-2017 TK78_RS10380 985886af87799a1899ad4bd9f03a4329 106 TIGRFAM TIGR03988 antisig_RsrA: mycothiol system anti-sigma-R factor 10 84 1.6E-30 T 09-03-2017 IPR024020 Anti sigma-R factor, mycothiol system,RsrA TK78_RS10380 985886af87799a1899ad4bd9f03a4329 106 Pfam PF13490 Putative zinc-finger 11 44 7.9E-9 T 09-03-2017 IPR027383 Putative zinc-finger TK78_RS10380 985886af87799a1899ad4bd9f03a4329 106 TIGRFAM TIGR02949 anti_SigH_actin: anti-sigma factor, TIGR02949 family 4 85 1.1E-36 T 09-03-2017 IPR014295 Anti-sigma factor TK78_RS15380 1766f988f65abb33396d99a7a38a664e 436 SUPERFAMILY SSF88713 162 393 2.78E-26 T 09-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 TK78_RS15380 1766f988f65abb33396d99a7a38a664e 436 SUPERFAMILY SSF88713 108 132 2.78E-26 T 09-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 TK78_RS15380 1766f988f65abb33396d99a7a38a664e 436 Gene3D G3DSA:3.20.20.370 94 393 3.5E-11 T 09-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 TK78_RS26510 aa7cf8bf752da1a8e657f8361a4897c4 275 SUPERFAMILY SSF63992 1 271 8.63E-86 T 09-03-2017 IPR007035 Peptidase M55, D-aminopeptidase TK78_RS26510 aa7cf8bf752da1a8e657f8361a4897c4 275 PIRSF PIRSF015853 1 274 1.1E-86 T 09-03-2017 IPR007035 Peptidase M55, D-aminopeptidase TK78_RS26510 aa7cf8bf752da1a8e657f8361a4897c4 275 Gene3D G3DSA:3.30.1360.130 208 271 2.0E-14 T 09-03-2017 TK78_RS26510 aa7cf8bf752da1a8e657f8361a4897c4 275 Pfam PF04951 D-aminopeptidase 1 263 2.9E-95 T 09-03-2017 IPR007035 Peptidase M55, D-aminopeptidase TK78_RS26510 aa7cf8bf752da1a8e657f8361a4897c4 275 Gene3D G3DSA:3.40.50.10780 1 207 2.9E-76 T 09-03-2017 IPR027476 D-aminopeptidase, N-terminal TK78_RS15015 29d6e3d15f227ae963c15077420f658d 463 SUPERFAMILY SSF53756 13 461 2.7E-108 T 09-03-2017 TK78_RS15015 29d6e3d15f227ae963c15077420f658d 463 Gene3D G3DSA:3.40.50.2000 12 249 4.6E-54 T 09-03-2017 TK78_RS15015 29d6e3d15f227ae963c15077420f658d 463 Gene3D G3DSA:3.40.50.2000 250 442 9.2E-59 T 09-03-2017 TK78_RS15015 29d6e3d15f227ae963c15077420f658d 463 Pfam PF00982 Glycosyltransferase family 20 74 460 1.0E-101 T 09-03-2017 IPR001830 Glycosyl transferase, family 20 GO:0003824|GO:0005992 TK78_RS18200 c50ad7def49324207c5e369d558d4311 206 Gene3D G3DSA:3.40.50.2300 5 125 1.7E-34 T 09-03-2017 TK78_RS18200 c50ad7def49324207c5e369d558d4311 206 SUPERFAMILY SSF52172 6 134 2.99E-31 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS18200 c50ad7def49324207c5e369d558d4311 206 SMART SM00421 143 200 1.8E-17 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS18200 c50ad7def49324207c5e369d558d4311 206 SUPERFAMILY SSF46894 130 206 8.16E-18 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS18200 c50ad7def49324207c5e369d558d4311 206 Pfam PF00196 Bacterial regulatory proteins, luxR family 145 200 1.2E-14 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS18200 c50ad7def49324207c5e369d558d4311 206 Gene3D G3DSA:1.10.10.10 126 206 7.0E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS18200 c50ad7def49324207c5e369d558d4311 206 SMART SM00448 7 120 1.1E-25 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS18200 c50ad7def49324207c5e369d558d4311 206 Pfam PF00072 Response regulator receiver domain 9 120 1.4E-24 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS18200 c50ad7def49324207c5e369d558d4311 206 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 160 176 7.8E-9 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS18200 c50ad7def49324207c5e369d558d4311 206 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 176 188 7.8E-9 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS18200 c50ad7def49324207c5e369d558d4311 206 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 146 160 7.8E-9 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS28880 0fd3469ea6415903dfd8b19800d86a63 295 Pfam PF00561 alpha/beta hydrolase fold 25 275 8.8E-17 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS28880 0fd3469ea6415903dfd8b19800d86a63 295 SUPERFAMILY SSF53474 6 273 1.97E-37 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS28880 0fd3469ea6415903dfd8b19800d86a63 295 Gene3D G3DSA:3.40.50.1820 4 272 2.6E-40 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS10085 88515dc67b149efa5e375ceae8a66c3b 142 SUPERFAMILY SSF51306 20 117 4.19E-21 T 09-03-2017 IPR015927 Peptidase S24/S26A/S26B/S26C TK78_RS10085 88515dc67b149efa5e375ceae8a66c3b 142 Gene3D G3DSA:2.10.109.10 19 115 2.2E-16 T 09-03-2017 IPR028360 Peptidase S24/S26, beta-ribbon domain TK78_RS10085 88515dc67b149efa5e375ceae8a66c3b 142 TIGRFAM TIGR02754 sod_Ni_protease: nickel-type superoxide dismutase maturation protease 22 105 3.6E-21 T 09-03-2017 IPR014124 Peptidase S26A, superoxide dismutase maturation protease, nickel-type TK78_RS10085 88515dc67b149efa5e375ceae8a66c3b 142 Pfam PF00717 Peptidase S24-like 22 82 2.2E-10 T 09-03-2017 IPR019759 Peptidase S24/S26A/S26B TK78_RS32340 2facadca4427189ffac527f9edc64d22 384 SUPERFAMILY SSF56112 7 285 4.74E-69 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS32340 2facadca4427189ffac527f9edc64d22 384 Gene3D G3DSA:1.10.510.10 84 267 4.0E-46 T 09-03-2017 TK78_RS32340 2facadca4427189ffac527f9edc64d22 384 SMART SM00220 10 274 2.8E-51 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS32340 2facadca4427189ffac527f9edc64d22 384 Pfam PF00069 Protein kinase domain 15 265 8.5E-44 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS32340 2facadca4427189ffac527f9edc64d22 384 Gene3D G3DSA:3.30.200.20 3 83 1.7E-22 T 09-03-2017 TK78_RS32340 2facadca4427189ffac527f9edc64d22 384 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 138 150 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS06305 c63cb6c1aa0142e57ca9494aab906934 387 Pfam PF13579 Glycosyl transferase 4-like domain 17 176 5.9E-10 T 09-03-2017 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 TK78_RS06305 c63cb6c1aa0142e57ca9494aab906934 387 Gene3D G3DSA:3.40.50.2000 195 357 1.9E-21 T 09-03-2017 TK78_RS06305 c63cb6c1aa0142e57ca9494aab906934 387 SUPERFAMILY SSF53756 2 381 3.18E-56 T 09-03-2017 TK78_RS06305 c63cb6c1aa0142e57ca9494aab906934 387 Pfam PF00534 Glycosyl transferases group 1 185 352 1.4E-25 T 09-03-2017 IPR001296 Glycosyl transferase, family 1 TK78_RS13575 3e879406f3dc937f3c5539379b1c3c4f 230 Gene3D G3DSA:1.10.10.10 129 222 4.2E-24 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS13575 3e879406f3dc937f3c5539379b1c3c4f 230 Gene3D G3DSA:3.40.50.2300 6 128 2.0E-36 T 09-03-2017 TK78_RS13575 3e879406f3dc937f3c5539379b1c3c4f 230 SMART SM00421 163 220 1.3E-17 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS13575 3e879406f3dc937f3c5539379b1c3c4f 230 SUPERFAMILY SSF52172 7 136 1.12E-33 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS13575 3e879406f3dc937f3c5539379b1c3c4f 230 SUPERFAMILY SSF46894 152 222 3.3E-18 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS13575 3e879406f3dc937f3c5539379b1c3c4f 230 Pfam PF00072 Response regulator receiver domain 10 122 3.2E-27 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS13575 3e879406f3dc937f3c5539379b1c3c4f 230 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 180 196 5.7E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS13575 3e879406f3dc937f3c5539379b1c3c4f 230 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 166 180 5.7E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS13575 3e879406f3dc937f3c5539379b1c3c4f 230 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 196 208 5.7E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS13575 3e879406f3dc937f3c5539379b1c3c4f 230 Pfam PF00196 Bacterial regulatory proteins, luxR family 165 219 3.6E-16 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS13575 3e879406f3dc937f3c5539379b1c3c4f 230 ProSitePatterns PS00622 LuxR-type HTH domain signature. 180 207 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS13575 3e879406f3dc937f3c5539379b1c3c4f 230 SMART SM00448 8 121 6.9E-29 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS10025 7f2328304251f0ace6212f93fa119047 353 Pfam PF03551 Transcriptional regulator PadR-like family 14 82 6.0E-22 T 09-03-2017 IPR005149 Transcription regulator PadR, N-terminal TK78_RS10025 7f2328304251f0ace6212f93fa119047 353 SUPERFAMILY SSF46785 10 105 4.74E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS10025 7f2328304251f0ace6212f93fa119047 353 Gene3D G3DSA:1.10.10.10 4 100 5.2E-30 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS17495 7ce114fb1110e50107624fad9faef09f 212 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 46 60 2.8E-9 T 09-03-2017 TK78_RS17495 7ce114fb1110e50107624fad9faef09f 212 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 77 93 2.8E-9 T 09-03-2017 TK78_RS17495 7ce114fb1110e50107624fad9faef09f 212 TIGRFAM TIGR00566 trpG_papA: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase 5 189 1.5E-60 T 09-03-2017 IPR006221 Anthranilate synthase/para-aminobenzoate synthase like domain GO:0008152 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 TK78_RS17495 7ce114fb1110e50107624fad9faef09f 212 SUPERFAMILY SSF52317 4 191 4.59E-58 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS17495 7ce114fb1110e50107624fad9faef09f 212 Gene3D G3DSA:3.40.50.880 4 191 3.2E-67 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS17495 7ce114fb1110e50107624fad9faef09f 212 Pfam PF00117 Glutamine amidotransferase class-I 7 188 2.0E-51 T 09-03-2017 IPR017926 Glutamine amidotransferase TK78_RS17495 7ce114fb1110e50107624fad9faef09f 212 PRINTS PR00096 Glutamine amidotransferase superfamily signature 49 58 1.3E-13 T 09-03-2017 TK78_RS17495 7ce114fb1110e50107624fad9faef09f 212 PRINTS PR00096 Glutamine amidotransferase superfamily signature 77 88 1.3E-13 T 09-03-2017 TK78_RS17495 7ce114fb1110e50107624fad9faef09f 212 PRINTS PR00096 Glutamine amidotransferase superfamily signature 167 180 1.3E-13 T 09-03-2017 TK78_RS17495 7ce114fb1110e50107624fad9faef09f 212 PRINTS PR00097 Anthranilate synthase component II signature 122 134 2.2E-34 T 09-03-2017 TK78_RS17495 7ce114fb1110e50107624fad9faef09f 212 PRINTS PR00097 Anthranilate synthase component II signature 167 180 2.2E-34 T 09-03-2017 TK78_RS17495 7ce114fb1110e50107624fad9faef09f 212 PRINTS PR00097 Anthranilate synthase component II signature 5 19 2.2E-34 T 09-03-2017 TK78_RS17495 7ce114fb1110e50107624fad9faef09f 212 PRINTS PR00097 Anthranilate synthase component II signature 102 110 2.2E-34 T 09-03-2017 TK78_RS17495 7ce114fb1110e50107624fad9faef09f 212 PRINTS PR00097 Anthranilate synthase component II signature 77 88 2.2E-34 T 09-03-2017 TK78_RS17495 7ce114fb1110e50107624fad9faef09f 212 PRINTS PR00097 Anthranilate synthase component II signature 49 58 2.2E-34 T 09-03-2017 TK78_RS22105 d5efce6b53811abb561902f0df0eece1 229 Pfam PF02482 Sigma 54 modulation protein / S30EA ribosomal protein 3 100 2.1E-19 T 09-03-2017 IPR003489 Ribosomal protein S30Ae/sigma 54 modulation protein GO:0044238 TK78_RS22105 d5efce6b53811abb561902f0df0eece1 229 Gene3D G3DSA:3.30.160.100 2 101 3.5E-26 T 09-03-2017 IPR003489 Ribosomal protein S30Ae/sigma 54 modulation protein GO:0044238 TK78_RS22105 d5efce6b53811abb561902f0df0eece1 229 TIGRFAM TIGR00741 yfiA: ribosomal subunit interface protein 2 104 5.5E-22 T 09-03-2017 IPR003489 Ribosomal protein S30Ae/sigma 54 modulation protein GO:0044238 TK78_RS22105 d5efce6b53811abb561902f0df0eece1 229 SUPERFAMILY SSF69754 3 109 4.58E-23 T 09-03-2017 IPR003489 Ribosomal protein S30Ae/sigma 54 modulation protein GO:0044238 TK78_RS22105 d5efce6b53811abb561902f0df0eece1 229 Pfam PF16321 Sigma 54 modulation/S30EA ribosomal protein C terminus 154 207 9.3E-22 T 09-03-2017 IPR032528 Sigma 54 modulation/S30EA ribosomal protein, C-terminal TK78_RS13715 7d0ad190a35119e977f7d1ffcded4ed2 275 Pfam PF00005 ABC transporter 46 183 7.0E-32 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS13715 7d0ad190a35119e977f7d1ffcded4ed2 275 ProSitePatterns PS00211 ABC transporters family signature. 155 169 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS13715 7d0ad190a35119e977f7d1ffcded4ed2 275 SMART SM00382 53 245 8.7E-19 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS13715 7d0ad190a35119e977f7d1ffcded4ed2 275 Gene3D G3DSA:3.40.50.300 18 230 1.3E-64 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13715 7d0ad190a35119e977f7d1ffcded4ed2 275 SUPERFAMILY SSF52540 25 233 1.4E-61 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15035 e5917ca0b4bacf73177d4d881e7e5bd4 433 SUPERFAMILY SSF55874 301 425 4.11E-15 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS15035 e5917ca0b4bacf73177d4d881e7e5bd4 433 Pfam PF07730 Histidine kinase 232 296 3.9E-14 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS15035 e5917ca0b4bacf73177d4d881e7e5bd4 433 SMART SM00387 330 428 1.1E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS15035 e5917ca0b4bacf73177d4d881e7e5bd4 433 Pfam PF13796 Putative sensor 24 204 2.4E-36 T 09-03-2017 IPR025828 Putative sensor domain TK78_RS15035 e5917ca0b4bacf73177d4d881e7e5bd4 433 Gene3D G3DSA:3.30.565.10 306 428 1.1E-9 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS31610 8f3c2d415b6b56027f75c02ec3ecfcc8 100 ProDom PD002319 SUBUNIT GAMMA HYDROLASE UREASE UREA AMIDOHYDROLASE UREASE ALPHA GAMMA/BETA METAL-BINDING 9 99 9.0E-45 T 09-03-2017 IPR002026 Urease, gamma/gamma-beta subunit GO:0016151|GO:0043419 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 TK78_RS31610 8f3c2d415b6b56027f75c02ec3ecfcc8 100 Pfam PF00547 Urease, gamma subunit 2 99 2.3E-47 T 09-03-2017 IPR002026 Urease, gamma/gamma-beta subunit GO:0016151|GO:0043419 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 TK78_RS31610 8f3c2d415b6b56027f75c02ec3ecfcc8 100 PIRSF PIRSF001223 1 100 4.4E-52 T 09-03-2017 IPR012010 Urease, gamma subunit GO:0009039|GO:0019627 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 TK78_RS31610 8f3c2d415b6b56027f75c02ec3ecfcc8 100 SUPERFAMILY SSF54111 2 99 5.49E-46 T 09-03-2017 IPR002026 Urease, gamma/gamma-beta subunit GO:0016151|GO:0043419 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 TK78_RS31610 8f3c2d415b6b56027f75c02ec3ecfcc8 100 Gene3D G3DSA:3.30.280.10 2 99 1.7E-49 T 09-03-2017 IPR002026 Urease, gamma/gamma-beta subunit GO:0016151|GO:0043419 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 TK78_RS31610 8f3c2d415b6b56027f75c02ec3ecfcc8 100 TIGRFAM TIGR00193 urease_gam: urease, gamma subunit 2 99 9.8E-51 T 09-03-2017 IPR002026 Urease, gamma/gamma-beta subunit GO:0016151|GO:0043419 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 TK78_RS31610 8f3c2d415b6b56027f75c02ec3ecfcc8 100 Hamap MF_00739 Urease subunit gamma [ureA]. 1 100 34.819 T 09-03-2017 IPR012010 Urease, gamma subunit GO:0009039|GO:0019627 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 TK78_RS25640 b662338f2f0e123c9475ffe1b64e9bff 832 SUPERFAMILY SSF53271 77 208 1.86E-6 T 09-03-2017 IPR029057 Phosphoribosyltransferase-like TK78_RS25640 b662338f2f0e123c9475ffe1b64e9bff 832 Pfam PF12500 TRSP domain C terminus to PRTase_2 277 418 6.4E-47 T 09-03-2017 IPR022537 TRSP domain TK78_RS25640 b662338f2f0e123c9475ffe1b64e9bff 832 Pfam PF15609 Phosphoribosyl transferase 37 227 2.5E-68 T 09-03-2017 IPR029057 Phosphoribosyltransferase-like TK78_RS25640 b662338f2f0e123c9475ffe1b64e9bff 832 Gene3D G3DSA:3.40.50.2020 69 202 4.2E-6 T 09-03-2017 IPR029057 Phosphoribosyltransferase-like TK78_RS25640 b662338f2f0e123c9475ffe1b64e9bff 832 Pfam PF11202 Phosphoribosyl transferase (PRTase) 458 708 1.6E-107 T 09-03-2017 IPR011215 Phosphoribosyl transferase TK78_RS25640 b662338f2f0e123c9475ffe1b64e9bff 832 Pfam PF15608 PELOTA RNA binding domain 735 814 5.0E-35 T 09-03-2017 IPR028157 PELOTA RNA-binding domain TK78_RS26410 b8012c1ad4024bbd42d7ba1c701641a2 365 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 316 324 - T 09-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 TK78_RS26410 b8012c1ad4024bbd42d7ba1c701641a2 365 SUPERFAMILY SSF63380 53 145 1.18E-22 T 09-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 TK78_RS26410 b8012c1ad4024bbd42d7ba1c701641a2 365 SUPERFAMILY SSF52343 143 265 5.76E-25 T 09-03-2017 TK78_RS26410 b8012c1ad4024bbd42d7ba1c701641a2 365 Gene3D G3DSA:3.10.20.30 260 363 5.1E-25 T 09-03-2017 IPR012675 Beta-grasp domain TK78_RS26410 b8012c1ad4024bbd42d7ba1c701641a2 365 Pfam PF00175 Oxidoreductase NAD-binding domain 157 247 1.6E-7 T 09-03-2017 IPR001433 Oxidoreductase FAD/NAD(P)-binding GO:0016491|GO:0055114 TK78_RS26410 b8012c1ad4024bbd42d7ba1c701641a2 365 Gene3D G3DSA:3.40.50.80 152 259 8.4E-25 T 09-03-2017 TK78_RS26410 b8012c1ad4024bbd42d7ba1c701641a2 365 PRINTS PR00409 Phthalate dioxygenase reductase family signature 97 111 2.0E-31 T 09-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 TK78_RS26410 b8012c1ad4024bbd42d7ba1c701641a2 365 PRINTS PR00409 Phthalate dioxygenase reductase family signature 85 97 2.0E-31 T 09-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 TK78_RS26410 b8012c1ad4024bbd42d7ba1c701641a2 365 PRINTS PR00409 Phthalate dioxygenase reductase family signature 121 135 2.0E-31 T 09-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 TK78_RS26410 b8012c1ad4024bbd42d7ba1c701641a2 365 PRINTS PR00409 Phthalate dioxygenase reductase family signature 156 175 2.0E-31 T 09-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 TK78_RS26410 b8012c1ad4024bbd42d7ba1c701641a2 365 PRINTS PR00409 Phthalate dioxygenase reductase family signature 234 242 2.0E-31 T 09-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 TK78_RS26410 b8012c1ad4024bbd42d7ba1c701641a2 365 PRINTS PR00409 Phthalate dioxygenase reductase family signature 181 190 2.0E-31 T 09-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 TK78_RS26410 b8012c1ad4024bbd42d7ba1c701641a2 365 PRINTS PR00409 Phthalate dioxygenase reductase family signature 75 85 2.0E-31 T 09-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 TK78_RS26410 b8012c1ad4024bbd42d7ba1c701641a2 365 Gene3D G3DSA:2.40.30.10 50 145 3.0E-26 T 09-03-2017 TK78_RS26410 b8012c1ad4024bbd42d7ba1c701641a2 365 SUPERFAMILY SSF54292 256 364 7.73E-24 T 09-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 TK78_RS26410 b8012c1ad4024bbd42d7ba1c701641a2 365 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 287 355 3.8E-11 T 09-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 TK78_RS07955 c2fc1f739d4ce8b3c8121b095a6c58e9 504 Pfam PF00171 Aldehyde dehydrogenase family 29 484 1.5E-170 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS07955 c2fc1f739d4ce8b3c8121b095a6c58e9 504 Gene3D G3DSA:3.40.309.10 274 464 4.3E-66 T 09-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 TK78_RS07955 c2fc1f739d4ce8b3c8121b095a6c58e9 504 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 258 265 - T 09-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 TK78_RS07955 c2fc1f739d4ce8b3c8121b095a6c58e9 504 SUPERFAMILY SSF53720 15 488 1.17E-158 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS07955 c2fc1f739d4ce8b3c8121b095a6c58e9 504 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 286 297 - T 09-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 TK78_RS07955 c2fc1f739d4ce8b3c8121b095a6c58e9 504 Gene3D G3DSA:3.40.605.10 16 273 4.5E-94 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS20150 c055f2488876cb4b0925e02e216a9207 246 SUPERFAMILY SSF64288 55 233 6.6E-37 T 09-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain TK78_RS20150 c055f2488876cb4b0925e02e216a9207 246 SMART SM00866 88 228 6.7E-27 T 09-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 TK78_RS20150 c055f2488876cb4b0925e02e216a9207 246 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 41 57 5.9E-9 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS20150 c055f2488876cb4b0925e02e216a9207 246 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 27 41 5.9E-9 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS20150 c055f2488876cb4b0925e02e216a9207 246 Gene3D G3DSA:1.10.10.10 3 73 7.3E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS20150 c055f2488876cb4b0925e02e216a9207 246 Gene3D G3DSA:3.40.1410.10 77 232 7.3E-37 T 09-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain TK78_RS20150 c055f2488876cb4b0925e02e216a9207 246 SMART SM00345 8 67 4.3E-14 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS20150 c055f2488876cb4b0925e02e216a9207 246 Pfam PF07702 UTRA domain 90 226 1.8E-27 T 09-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 TK78_RS20150 c055f2488876cb4b0925e02e216a9207 246 Pfam PF00392 Bacterial regulatory proteins, gntR family 6 63 1.8E-15 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS20150 c055f2488876cb4b0925e02e216a9207 246 SUPERFAMILY SSF46785 4 79 5.18E-18 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS11025 f02d85233988f1885bbc21f9e511162f 414 Gene3D G3DSA:3.40.190.10 157 348 9.4E-55 T 09-03-2017 TK78_RS11025 f02d85233988f1885bbc21f9e511162f 414 Pfam PF13416 Bacterial extracellular solute-binding protein 53 358 8.6E-49 T 09-03-2017 TK78_RS11025 f02d85233988f1885bbc21f9e511162f 414 SUPERFAMILY SSF53850 37 409 1.16E-91 T 09-03-2017 TK78_RS11025 f02d85233988f1885bbc21f9e511162f 414 Gene3D G3DSA:3.40.190.10 33 156 1.8E-6 T 09-03-2017 TK78_RS07945 e942f5f05bea4813142adead0713edd2 385 Pfam PF08402 TOBE domain 286 366 2.4E-16 T 09-03-2017 IPR013611 Transport-associated OB, type 2 GO:0005215|GO:0005524|GO:0006810|GO:0016820|GO:0043190 TK78_RS07945 e942f5f05bea4813142adead0713edd2 385 Pfam PF00005 ABC transporter 28 167 3.1E-32 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS07945 e942f5f05bea4813142adead0713edd2 385 SMART SM00382 36 272 1.4E-12 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS07945 e942f5f05bea4813142adead0713edd2 385 TIGRFAM TIGR01187 potA: polyamine ABC transporter, ATP-binding protein 42 364 1.8E-110 T 09-03-2017 IPR005893 Spermidine/putrescine ABC transporter, ATP-binding subunit GO:0015417|GO:0015846|GO:0043190 TK78_RS07945 e942f5f05bea4813142adead0713edd2 385 Gene3D G3DSA:2.40.50.100 244 298 1.8E-4 T 09-03-2017 TK78_RS07945 e942f5f05bea4813142adead0713edd2 385 SUPERFAMILY SSF52540 12 248 2.73E-86 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07945 e942f5f05bea4813142adead0713edd2 385 SUPERFAMILY SSF50331 243 366 7.94E-17 T 09-03-2017 IPR008995 Molybdate/tungstate binding, C-terminal TK78_RS07945 e942f5f05bea4813142adead0713edd2 385 Gene3D G3DSA:3.40.50.300 12 240 9.9E-76 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07945 e942f5f05bea4813142adead0713edd2 385 ProSitePatterns PS00211 ABC transporters family signature. 140 154 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS22085 c690839d5185502ea3c1affafff0a323 225 Pfam PF00072 Response regulator receiver domain 5 114 6.8E-29 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS22085 c690839d5185502ea3c1affafff0a323 225 SUPERFAMILY SSF52172 4 176 4.13E-43 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS22085 c690839d5185502ea3c1affafff0a323 225 SMART SM00448 3 113 2.3E-44 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS22085 c690839d5185502ea3c1affafff0a323 225 Gene3D G3DSA:1.10.10.10 124 222 5.0E-34 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS22085 c690839d5185502ea3c1affafff0a323 225 Gene3D G3DSA:3.40.50.2300 2 123 1.7E-40 T 09-03-2017 TK78_RS22085 c690839d5185502ea3c1affafff0a323 225 Pfam PF00486 Transcriptional regulatory protein, C terminal 146 221 1.8E-25 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS22085 c690839d5185502ea3c1affafff0a323 225 SMART SM00862 146 222 3.3E-22 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS11675 c29ce36fa6f05b70649bda8423efada7 136 Pfam PF01042 Endoribonuclease L-PSP 15 134 7.4E-26 T 09-03-2017 IPR006175 YjgF/YER057c/UK114 family TK78_RS11675 c29ce36fa6f05b70649bda8423efada7 136 SUPERFAMILY SSF55298 5 135 2.2E-30 T 09-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like TK78_RS11675 c29ce36fa6f05b70649bda8423efada7 136 Gene3D G3DSA:3.30.1330.40 2 135 5.6E-36 T 09-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like TK78_RS00690 97d9be3e6b4c89cd7b896d97c45426e7 328 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 112 288 2.1E-46 T 09-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 TK78_RS00690 97d9be3e6b4c89cd7b896d97c45426e7 328 SUPERFAMILY SSF52283 29 130 5.78E-9 T 09-03-2017 TK78_RS00690 97d9be3e6b4c89cd7b896d97c45426e7 328 Gene3D G3DSA:3.40.50.720 119 290 4.4E-50 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS00690 97d9be3e6b4c89cd7b896d97c45426e7 328 SUPERFAMILY SSF51735 102 289 5.56E-46 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS00690 97d9be3e6b4c89cd7b896d97c45426e7 328 Gene3D G3DSA:3.40.50.720 12 118 1.6E-11 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31860 d2b4cabb0097d3c758e12637cec446b2 523 Pfam PF02151 UvrB/uvrC motif 425 456 4.9E-7 T 09-03-2017 IPR001943 UVR domain GO:0005515 TK78_RS31860 d2b4cabb0097d3c758e12637cec446b2 523 Gene3D G3DSA:1.10.8.60 351 435 7.6E-22 T 09-03-2017 TK78_RS31860 d2b4cabb0097d3c758e12637cec446b2 523 SUPERFAMILY SSF52540 170 420 3.53E-39 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31860 d2b4cabb0097d3c758e12637cec446b2 523 SUPERFAMILY SSF81923 10 146 2.35E-29 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS31860 d2b4cabb0097d3c758e12637cec446b2 523 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 22 74 1.4E-19 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS31860 d2b4cabb0097d3c758e12637cec446b2 523 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 99 148 1.7E-13 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS31860 d2b4cabb0097d3c758e12637cec446b2 523 Gene3D G3DSA:3.40.50.300 172 348 8.5E-23 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31860 d2b4cabb0097d3c758e12637cec446b2 523 Gene3D G3DSA:1.10.1780.10 113 156 5.4E-9 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS31860 d2b4cabb0097d3c758e12637cec446b2 523 Gene3D G3DSA:1.10.1780.10 8 112 1.7E-39 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS34485 1a8458fba2fb057c28f77d9ac81cf0a7 186 SUPERFAMILY SSF48498 80 175 1.2E-24 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS34485 1a8458fba2fb057c28f77d9ac81cf0a7 186 SUPERFAMILY SSF46689 3 73 1.39E-16 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS34485 1a8458fba2fb057c28f77d9ac81cf0a7 186 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 30 53 6.1E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS34485 1a8458fba2fb057c28f77d9ac81cf0a7 186 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 9 22 6.1E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS34485 1a8458fba2fb057c28f77d9ac81cf0a7 186 Pfam PF00440 Bacterial regulatory proteins, tetR family 9 55 2.8E-12 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS34485 1a8458fba2fb057c28f77d9ac81cf0a7 186 Gene3D G3DSA:1.10.357.10 2 177 9.4E-26 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS06185 80baa39b3ac8275e2990826177eaab12 206 Pfam PF00440 Bacterial regulatory proteins, tetR family 21 67 9.5E-12 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS06185 80baa39b3ac8275e2990826177eaab12 206 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 21 34 9.6E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS06185 80baa39b3ac8275e2990826177eaab12 206 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 42 65 9.6E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS06185 80baa39b3ac8275e2990826177eaab12 206 Gene3D G3DSA:1.10.357.10 7 190 2.2E-28 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS06185 80baa39b3ac8275e2990826177eaab12 206 SUPERFAMILY SSF46689 7 86 8.72E-17 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS17580 93fc48fd18b80168cc309309c2a5064b 352 Pfam PF00970 Oxidoreductase FAD-binding domain 5 105 2.7E-13 T 09-03-2017 IPR008333 Oxidoreductase, FAD-binding domain Reactome: R-HSA-1237044 TK78_RS17580 93fc48fd18b80168cc309309c2a5064b 352 SUPERFAMILY SSF52343 94 241 4.85E-29 T 09-03-2017 TK78_RS17580 93fc48fd18b80168cc309309c2a5064b 352 PRINTS PR00409 Phthalate dioxygenase reductase family signature 115 134 7.2E-7 T 09-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 TK78_RS17580 93fc48fd18b80168cc309309c2a5064b 352 PRINTS PR00409 Phthalate dioxygenase reductase family signature 53 67 7.2E-7 T 09-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 TK78_RS17580 93fc48fd18b80168cc309309c2a5064b 352 PRINTS PR00409 Phthalate dioxygenase reductase family signature 93 107 7.2E-7 T 09-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 TK78_RS17580 93fc48fd18b80168cc309309c2a5064b 352 Gene3D G3DSA:2.40.30.10 2 96 2.7E-25 T 09-03-2017 TK78_RS17580 93fc48fd18b80168cc309309c2a5064b 352 Gene3D G3DSA:3.40.50.80 97 236 6.4E-33 T 09-03-2017 TK78_RS17580 93fc48fd18b80168cc309309c2a5064b 352 SUPERFAMILY SSF63380 2 109 5.02E-24 T 09-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 TK78_RS17580 93fc48fd18b80168cc309309c2a5064b 352 Gene3D G3DSA:3.10.20.30 237 347 9.0E-27 T 09-03-2017 IPR012675 Beta-grasp domain TK78_RS17580 93fc48fd18b80168cc309309c2a5064b 352 Pfam PF00175 Oxidoreductase NAD-binding domain 118 225 8.5E-9 T 09-03-2017 IPR001433 Oxidoreductase FAD/NAD(P)-binding GO:0016491|GO:0055114 TK78_RS17580 93fc48fd18b80168cc309309c2a5064b 352 SUPERFAMILY SSF54292 234 349 1.31E-23 T 09-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 TK78_RS17580 93fc48fd18b80168cc309309c2a5064b 352 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 271 341 6.0E-12 T 09-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 TK78_RS17580 93fc48fd18b80168cc309309c2a5064b 352 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 299 307 - T 09-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 TK78_RS00355 f03c38b9a7ebfa84daabd4e227c09ced 158 SUPERFAMILY SSF69118 18 155 2.09E-34 T 09-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 TK78_RS00355 f03c38b9a7ebfa84daabd4e227c09ced 158 TIGRFAM TIGR00778 ahpD_dom: alkylhydroperoxidase AhpD family core domain 41 89 4.8E-19 T 09-03-2017 IPR004675 Alkylhydroperoxidase AhpD core GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 TK78_RS00355 f03c38b9a7ebfa84daabd4e227c09ced 158 Pfam PF02627 Carboxymuconolactone decarboxylase family 20 106 5.1E-22 T 09-03-2017 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 TK78_RS00355 f03c38b9a7ebfa84daabd4e227c09ced 158 Gene3D G3DSA:1.20.1290.10 18 156 2.8E-37 T 09-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 TK78_RS05550 f30ee365c11b902623756c93630989cd 352 Gene3D G3DSA:3.40.50.1980 183 334 3.4E-24 T 09-03-2017 TK78_RS05550 f30ee365c11b902623756c93630989cd 352 SUPERFAMILY SSF53807 45 314 2.83E-51 T 09-03-2017 TK78_RS05550 f30ee365c11b902623756c93630989cd 352 Pfam PF01497 Periplasmic binding protein 109 305 3.8E-25 T 09-03-2017 IPR002491 ABC transporter periplasmic binding domain GO:0005488 TK78_RS05550 f30ee365c11b902623756c93630989cd 352 Gene3D G3DSA:3.40.50.1980 63 182 8.5E-26 T 09-03-2017 TK78_RS16190 9e363435364787da71159571063f6c01 351 Gene3D G3DSA:2.40.30.10 39 129 6.4E-23 T 09-03-2017 TK78_RS16190 9e363435364787da71159571063f6c01 351 Gene3D G3DSA:3.10.20.30 251 350 4.7E-19 T 09-03-2017 IPR012675 Beta-grasp domain TK78_RS16190 9e363435364787da71159571063f6c01 351 SUPERFAMILY SSF63380 40 138 5.11E-24 T 09-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 TK78_RS16190 9e363435364787da71159571063f6c01 351 Pfam PF00970 Oxidoreductase FAD-binding domain 66 136 4.0E-13 T 09-03-2017 IPR008333 Oxidoreductase, FAD-binding domain Reactome: R-HSA-1237044 TK78_RS16190 9e363435364787da71159571063f6c01 351 Pfam PF00175 Oxidoreductase NAD-binding domain 150 239 6.1E-7 T 09-03-2017 IPR001433 Oxidoreductase FAD/NAD(P)-binding GO:0016491|GO:0055114 TK78_RS16190 9e363435364787da71159571063f6c01 351 SUPERFAMILY SSF54292 250 350 5.66E-17 T 09-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 TK78_RS16190 9e363435364787da71159571063f6c01 351 SUPERFAMILY SSF52343 132 262 1.07E-21 T 09-03-2017 TK78_RS16190 9e363435364787da71159571063f6c01 351 Gene3D G3DSA:3.40.50.80 130 250 1.5E-19 T 09-03-2017 TK78_RS16190 9e363435364787da71159571063f6c01 351 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 277 341 9.4E-5 T 09-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 TK78_RS14360 977e06ea9f68eadeb1d30253d2b2db79 318 SUPERFAMILY SSF48498 172 316 1.08E-17 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS14360 977e06ea9f68eadeb1d30253d2b2db79 318 SMART SM00345 14 73 1.2E-16 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS14360 977e06ea9f68eadeb1d30253d2b2db79 318 Gene3D G3DSA:1.10.357.10 98 316 1.6E-45 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS14360 977e06ea9f68eadeb1d30253d2b2db79 318 Gene3D G3DSA:1.10.10.10 5 74 1.2E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS14360 977e06ea9f68eadeb1d30253d2b2db79 318 Pfam PF00392 Bacterial regulatory proteins, gntR family 10 73 4.7E-15 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS14360 977e06ea9f68eadeb1d30253d2b2db79 318 SUPERFAMILY SSF46689 101 161 7.77E-12 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS14360 977e06ea9f68eadeb1d30253d2b2db79 318 SUPERFAMILY SSF46785 1 83 1.93E-18 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS14360 977e06ea9f68eadeb1d30253d2b2db79 318 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 166 312 6.3E-12 T 09-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 TK78_RS14360 977e06ea9f68eadeb1d30253d2b2db79 318 Pfam PF00440 Bacterial regulatory proteins, tetR family 109 153 1.4E-6 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS22510 7f613963881adca6a87334e2132d45ab 289 Gene3D G3DSA:1.10.3720.10 92 279 2.6E-27 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS22510 7f613963881adca6a87334e2132d45ab 289 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 111 276 3.0E-21 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS22510 7f613963881adca6a87334e2132d45ab 289 SUPERFAMILY SSF161098 92 273 7.98E-35 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS00570 8a0a1229eb99903bf2d38ea395cd5579 192 PRINTS PR00787 Streptomyces extracellular neutral proteinase (M7) family signature 161 175 8.3E-17 T 09-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 TK78_RS00570 8a0a1229eb99903bf2d38ea395cd5579 192 PRINTS PR00787 Streptomyces extracellular neutral proteinase (M7) family signature 47 73 8.3E-17 T 09-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 TK78_RS00570 8a0a1229eb99903bf2d38ea395cd5579 192 PRINTS PR00787 Streptomyces extracellular neutral proteinase (M7) family signature 134 158 8.3E-17 T 09-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 TK78_RS00570 8a0a1229eb99903bf2d38ea395cd5579 192 SUPERFAMILY SSF55486 42 173 2.69E-21 T 09-03-2017 TK78_RS00570 8a0a1229eb99903bf2d38ea395cd5579 192 Gene3D G3DSA:3.40.390.10 42 174 1.3E-29 T 09-03-2017 IPR024079 Metallopeptidase, catalytic domain GO:0008237 TK78_RS00570 8a0a1229eb99903bf2d38ea395cd5579 192 Pfam PF02031 Streptomyces extracellular neutral proteinase (M7) family 41 176 3.3E-27 T 09-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 TK78_RS00570 8a0a1229eb99903bf2d38ea395cd5579 192 ProDom PD016028 PROTEASE METALLOPROTEASE EXTRACELLULAR NEUTRAL SMALL METAL-BINDING ZINC HYDROLASE SNAPALYSIN ZYMOGEN 64 169 2.0E-24 T 09-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 TK78_RS11545 237a7b108dcd12e6b9e14da438854e77 276 Pfam PF01478 Type IV leader peptidase family 129 241 1.3E-16 T 09-03-2017 IPR000045 Prepilin type IV endopeptidase, peptidase domain GO:0004190|GO:0016020 TK78_RS11545 237a7b108dcd12e6b9e14da438854e77 276 PRINTS PR00864 Type IV prepilin cysteine protease (C20) family signature 138 155 7.7E-7 T 09-03-2017 IPR014032 Peptidase A24A, prepilin type IV, bacterial TK78_RS11545 237a7b108dcd12e6b9e14da438854e77 276 PRINTS PR00864 Type IV prepilin cysteine protease (C20) family signature 195 205 7.7E-7 T 09-03-2017 IPR014032 Peptidase A24A, prepilin type IV, bacterial TK78_RS11545 237a7b108dcd12e6b9e14da438854e77 276 PRINTS PR00864 Type IV prepilin cysteine protease (C20) family signature 206 217 7.7E-7 T 09-03-2017 IPR014032 Peptidase A24A, prepilin type IV, bacterial TK78_RS06875 69fa48b2260d8a980be30b810ea31623 231 Pfam PF00486 Transcriptional regulatory protein, C terminal 152 228 7.8E-24 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS06875 69fa48b2260d8a980be30b810ea31623 231 SMART SM00448 2 112 8.7E-42 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS06875 69fa48b2260d8a980be30b810ea31623 231 Pfam PF00072 Response regulator receiver domain 4 112 5.0E-29 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS06875 69fa48b2260d8a980be30b810ea31623 231 SUPERFAMILY SSF52172 1 180 6.12E-40 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS06875 69fa48b2260d8a980be30b810ea31623 231 Gene3D G3DSA:1.10.10.10 132 229 7.2E-31 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS06875 69fa48b2260d8a980be30b810ea31623 231 SMART SM00862 152 228 3.6E-24 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS06875 69fa48b2260d8a980be30b810ea31623 231 Gene3D G3DSA:3.40.50.2300 1 121 7.5E-39 T 09-03-2017 TK78_RS01580 d9c5bbc58b181f4adcf515b51139c3f6 299 Pfam PF04075 Domain of unknown function (DUF385) 12 133 5.7E-43 T 09-03-2017 IPR004378 Deazaflavin-dependent nitroreductase/F420H(2)-dependent quinone reductase GO:0016491|GO:0055114 TK78_RS01580 d9c5bbc58b181f4adcf515b51139c3f6 299 Pfam PF01814 Hemerythrin HHE cation binding domain 162 289 2.6E-17 T 09-03-2017 IPR012312 Haemerythrin-like Reactome: R-HSA-390471 TK78_RS01580 d9c5bbc58b181f4adcf515b51139c3f6 299 Gene3D G3DSA:2.30.110.10 28 129 1.7E-10 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS01580 d9c5bbc58b181f4adcf515b51139c3f6 299 Gene3D G3DSA:1.20.120.520 135 296 4.9E-38 T 09-03-2017 TK78_RS01580 d9c5bbc58b181f4adcf515b51139c3f6 299 SUPERFAMILY SSF50475 27 132 1.59E-8 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS01580 d9c5bbc58b181f4adcf515b51139c3f6 299 TIGRFAM TIGR00026 hi_GC_TIGR00026: deazaflavin-dependent oxidoreductase, nitroreductase family 22 133 6.7E-33 T 09-03-2017 IPR004378 Deazaflavin-dependent nitroreductase/F420H(2)-dependent quinone reductase GO:0016491|GO:0055114 TK78_RS33045 3db7b975e86b95e7db5c19b154fc0f2d 277 Gene3D G3DSA:1.10.260.40 7 71 7.7E-10 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS33045 3db7b975e86b95e7db5c19b154fc0f2d 277 SUPERFAMILY SSF47413 12 70 7.41E-8 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS33045 3db7b975e86b95e7db5c19b154fc0f2d 277 Pfam PF13560 Helix-turn-helix domain 14 70 4.9E-10 T 09-03-2017 TK78_RS33045 3db7b975e86b95e7db5c19b154fc0f2d 277 SMART SM00530 17 72 5.1E-8 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS25920 aefe0ea1b44650f5052ad4546cd149e2 336 Pfam PF00296 Luciferase-like monooxygenase 19 316 2.4E-59 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS25920 aefe0ea1b44650f5052ad4546cd149e2 336 Gene3D G3DSA:3.20.20.30 1 333 7.5E-62 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS25920 aefe0ea1b44650f5052ad4546cd149e2 336 SUPERFAMILY SSF51679 1 328 5.63E-55 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS25920 aefe0ea1b44650f5052ad4546cd149e2 336 TIGRFAM TIGR03559 F420_Rv3520c: probable F420-dependent oxidoreductase, Rv3520c family 2 321 5.3E-134 T 09-03-2017 IPR019951 F420-dependent oxidoreductase-predicted, Rv3520c TK78_RS13160 73e662ab2dbadd7ac29fcb935bcc7f60 216 Pfam PF00573 Ribosomal protein L4/L1 family 17 202 2.0E-62 T 09-03-2017 IPR002136 Ribosomal protein L4/L1e GO:0003735|GO:0005840|GO:0006412 TK78_RS13160 73e662ab2dbadd7ac29fcb935bcc7f60 216 Gene3D G3DSA:3.40.1370.10 58 202 6.2E-50 T 09-03-2017 IPR023574 Ribosomal protein L4 domain GO:0003735|GO:0005840|GO:0006412 TK78_RS13160 73e662ab2dbadd7ac29fcb935bcc7f60 216 Hamap MF_01328_B 50S ribosomal protein L4 [rplD]. 9 207 32.525 T 09-03-2017 IPR013005 50S ribosomal protein uL4 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13160 73e662ab2dbadd7ac29fcb935bcc7f60 216 TIGRFAM TIGR03953 rplD_bact: 50S ribosomal protein uL4 17 202 4.2E-69 T 09-03-2017 IPR013005 50S ribosomal protein uL4 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13160 73e662ab2dbadd7ac29fcb935bcc7f60 216 SUPERFAMILY SSF52166 1 203 3.53E-73 T 09-03-2017 IPR023574 Ribosomal protein L4 domain GO:0003735|GO:0005840|GO:0006412 TK78_RS14450 5aad61b0b55050f6c5964eb9af453c89 175 Gene3D G3DSA:2.160.10.10 16 174 4.4E-49 T 09-03-2017 TK78_RS14450 5aad61b0b55050f6c5964eb9af453c89 175 SUPERFAMILY SSF51161 39 174 2.08E-42 T 09-03-2017 IPR011004 Trimeric LpxA-like TK78_RS14450 5aad61b0b55050f6c5964eb9af453c89 175 ProSitePatterns PS00101 Hexapeptide-repeat containing-transferases signature. 129 157 - T 09-03-2017 IPR018357 Hexapeptide transferase, conserved site GO:0016740 Reactome: R-HSA-446205 TK78_RS14450 5aad61b0b55050f6c5964eb9af453c89 175 Pfam PF14602 Hexapeptide repeat of succinyl-transferase 120 155 3.7E-8 T 09-03-2017 IPR001451 Hexapeptide repeat TK78_RS13020 e8c112c227770704c6c902e35bff2d58 167 Pfam PF01196 Ribosomal protein L17 20 116 3.4E-37 T 09-03-2017 IPR000456 Ribosomal protein L17 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13020 e8c112c227770704c6c902e35bff2d58 167 Gene3D G3DSA:3.90.1030.10 4 117 1.1E-45 T 09-03-2017 IPR000456 Ribosomal protein L17 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13020 e8c112c227770704c6c902e35bff2d58 167 TIGRFAM TIGR00059 L17: ribosomal protein bL17 10 117 1.4E-40 T 09-03-2017 IPR000456 Ribosomal protein L17 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13020 e8c112c227770704c6c902e35bff2d58 167 SUPERFAMILY SSF64263 1 117 2.75E-46 T 09-03-2017 IPR000456 Ribosomal protein L17 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13020 e8c112c227770704c6c902e35bff2d58 167 ProSitePatterns PS01167 Ribosomal protein L17 signature. 34 56 - T 09-03-2017 IPR000456 Ribosomal protein L17 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13020 e8c112c227770704c6c902e35bff2d58 167 Hamap MF_01368 50S ribosomal protein L17 [rplQ]. 5 116 27.04 T 09-03-2017 IPR000456 Ribosomal protein L17 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS25215 854e90f9d058ced8064b0a20667f2a5e 113 Gene3D G3DSA:3.30.70.830 8 109 2.9E-38 T 09-03-2017 TK78_RS25215 854e90f9d058ced8064b0a20667f2a5e 113 Pfam PF03091 CutA1 divalent ion tolerance protein 9 105 1.5E-34 T 09-03-2017 IPR004323 Divalent ion tolerance protein, CutA GO:0010038 TK78_RS25215 854e90f9d058ced8064b0a20667f2a5e 113 SUPERFAMILY SSF54913 7 107 2.41E-34 T 09-03-2017 IPR011322 Nitrogen regulatory PII-like, alpha/beta TK78_RS13000 2c7c61ec58b02d5313b28bb2df84338d 147 ProSitePatterns PS00783 Ribosomal protein L13 signature. 105 127 - T 09-03-2017 IPR023563 Ribosomal protein L13, conserved site GO:0003735|GO:0005840|GO:0006412 TK78_RS13000 2c7c61ec58b02d5313b28bb2df84338d 147 Hamap MF_01366 50S ribosomal protein L13 [rplM]. 15 146 27.385 T 09-03-2017 IPR005822 Ribosomal protein L13 GO:0003735|GO:0005840|GO:0006412 TK78_RS13000 2c7c61ec58b02d5313b28bb2df84338d 147 Gene3D G3DSA:3.90.1180.10 3 141 3.5E-61 T 09-03-2017 IPR005822 Ribosomal protein L13 GO:0003735|GO:0005840|GO:0006412 TK78_RS13000 2c7c61ec58b02d5313b28bb2df84338d 147 TIGRFAM TIGR01066 rplM_bact: ribosomal protein uL13 7 141 9.7E-60 T 09-03-2017 IPR005823 Ribosomal protein L13, bacterial-type GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13000 2c7c61ec58b02d5313b28bb2df84338d 147 SUPERFAMILY SSF52161 4 144 9.81E-58 T 09-03-2017 IPR005822 Ribosomal protein L13 GO:0003735|GO:0005840|GO:0006412 TK78_RS13000 2c7c61ec58b02d5313b28bb2df84338d 147 Pfam PF00572 Ribosomal protein L13 14 137 1.5E-54 T 09-03-2017 IPR005822 Ribosomal protein L13 GO:0003735|GO:0005840|GO:0006412 TK78_RS13000 2c7c61ec58b02d5313b28bb2df84338d 147 PIRSF PIRSF002181 2 147 1.1E-45 T 09-03-2017 IPR005822 Ribosomal protein L13 GO:0003735|GO:0005840|GO:0006412 TK78_RS18065 4c99d63c6a09c83e0d714bc07b5bedd5 275 SUPERFAMILY SSF51182 30 259 1.28E-20 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS18065 4c99d63c6a09c83e0d714bc07b5bedd5 275 Gene3D G3DSA:2.60.120.10 33 245 3.4E-23 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS18065 4c99d63c6a09c83e0d714bc07b5bedd5 275 Pfam PF07883 Cupin domain 188 246 8.9E-11 T 09-03-2017 IPR013096 Cupin 2, conserved barrel TK78_RS18065 4c99d63c6a09c83e0d714bc07b5bedd5 275 Pfam PF04962 KduI/IolB family 44 127 1.3E-5 T 09-03-2017 IPR021120 KduI/IolB isomerase GO:0016861 KEGG: 00040+5.3.1.17|MetaCyc: PWY-6507 TK78_RS04705 c4ccd4968535f6d472bef5534c781f4b 255 Pfam PF00557 Metallopeptidase family M24 11 245 2.5E-43 T 09-03-2017 IPR000994 Peptidase M24, structural domain TK78_RS04705 c4ccd4968535f6d472bef5534c781f4b 255 Hamap MF_01974 Methionine aminopeptidase [map]. 2 255 35.854 T 09-03-2017 IPR002467 Peptidase M24A, methionine aminopeptidase, subfamily 1 GO:0004177|GO:0006508|GO:0008235 TK78_RS04705 c4ccd4968535f6d472bef5534c781f4b 255 TIGRFAM TIGR00500 met_pdase_I: methionine aminopeptidase, type I 3 254 1.3E-76 T 09-03-2017 IPR002467 Peptidase M24A, methionine aminopeptidase, subfamily 1 GO:0004177|GO:0006508|GO:0008235 TK78_RS04705 c4ccd4968535f6d472bef5534c781f4b 255 PRINTS PR00599 Methionine aminopeptidase-1 signature 73 86 2.3E-20 T 09-03-2017 IPR001714 Peptidase M24, methionine aminopeptidase TK78_RS04705 c4ccd4968535f6d472bef5534c781f4b 255 PRINTS PR00599 Methionine aminopeptidase-1 signature 196 208 2.3E-20 T 09-03-2017 IPR001714 Peptidase M24, methionine aminopeptidase TK78_RS04705 c4ccd4968535f6d472bef5534c781f4b 255 PRINTS PR00599 Methionine aminopeptidase-1 signature 95 111 2.3E-20 T 09-03-2017 IPR001714 Peptidase M24, methionine aminopeptidase TK78_RS04705 c4ccd4968535f6d472bef5534c781f4b 255 PRINTS PR00599 Methionine aminopeptidase-1 signature 165 177 2.3E-20 T 09-03-2017 IPR001714 Peptidase M24, methionine aminopeptidase TK78_RS04705 c4ccd4968535f6d472bef5534c781f4b 255 SUPERFAMILY SSF55920 3 253 3.53E-72 T 09-03-2017 IPR000994 Peptidase M24, structural domain TK78_RS04705 c4ccd4968535f6d472bef5534c781f4b 255 Gene3D G3DSA:3.90.230.10 4 254 4.3E-77 T 09-03-2017 IPR000994 Peptidase M24, structural domain TK78_RS09495 3cc4a336af1191250b6dfac25c0ea1d7 97 TIGRFAM TIGR00106 TIGR00106: uncharacterized protein, MTH1187 family 1 94 1.6E-17 T 09-03-2017 IPR002767 Thiamine-binding protein TK78_RS09495 3cc4a336af1191250b6dfac25c0ea1d7 97 Gene3D G3DSA:3.30.70.930 1 92 1.4E-34 T 09-03-2017 IPR029756 MTH1187/YkoF-like TK78_RS09495 3cc4a336af1191250b6dfac25c0ea1d7 97 SUPERFAMILY SSF89957 1 95 5.1E-29 T 09-03-2017 IPR029756 MTH1187/YkoF-like TK78_RS09495 3cc4a336af1191250b6dfac25c0ea1d7 97 Pfam PF01910 Thiamine-binding protein 3 92 5.0E-29 T 09-03-2017 IPR002767 Thiamine-binding protein TK78_RS31235 04025ae836b48bbf4dbeb5a86b7f9dd2 575 Pfam PF00795 Carbon-nitrogen hydrolase 267 502 4.8E-25 T 09-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 TK78_RS31235 04025ae836b48bbf4dbeb5a86b7f9dd2 575 SUPERFAMILY SSF56317 261 531 1.26E-45 T 09-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 TK78_RS31235 04025ae836b48bbf4dbeb5a86b7f9dd2 575 TIGRFAM TIGR00546 lnt: apolipoprotein N-acyltransferase 113 497 5.4E-86 T 09-03-2017 IPR004563 Apolipoprotein N-acyltransferase GO:0016021|GO:0016410|GO:0042158 TK78_RS31235 04025ae836b48bbf4dbeb5a86b7f9dd2 575 Hamap MF_01148 Apolipoprotein N-acyltransferase [lnt]. 58 536 16.494 T 09-03-2017 IPR004563 Apolipoprotein N-acyltransferase GO:0016021|GO:0016410|GO:0042158 TK78_RS31235 04025ae836b48bbf4dbeb5a86b7f9dd2 575 Gene3D G3DSA:3.60.110.10 260 530 3.4E-40 T 09-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 TK78_RS32180 8ee8d2258c4fea977e1e1520fded952a 307 Pfam PF03547 Membrane transport protein 11 136 1.8E-9 T 09-03-2017 IPR004776 Membrane transport protein GO:0016021|GO:0055085 TK78_RS32180 8ee8d2258c4fea977e1e1520fded952a 307 Pfam PF03547 Membrane transport protein 162 299 1.4E-13 T 09-03-2017 IPR004776 Membrane transport protein GO:0016021|GO:0055085 TK78_RS25955 472244ed9f25b7451194ef41feb1a42e 484 Gene3D G3DSA:1.20.1250.20 23 207 5.2E-28 T 09-03-2017 TK78_RS25955 472244ed9f25b7451194ef41feb1a42e 484 Gene3D G3DSA:1.20.1250.20 279 481 4.1E-18 T 09-03-2017 TK78_RS25955 472244ed9f25b7451194ef41feb1a42e 484 Pfam PF07690 Major Facilitator Superfamily 32 424 1.9E-45 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS25955 472244ed9f25b7451194ef41feb1a42e 484 ProSitePatterns PS00216 Sugar transport proteins signature 1. 81 97 - T 09-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 TK78_RS25955 472244ed9f25b7451194ef41feb1a42e 484 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 28 436 7.2E-73 T 09-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 TK78_RS25955 472244ed9f25b7451194ef41feb1a42e 484 SUPERFAMILY SSF103473 16 214 2.09E-64 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS25955 472244ed9f25b7451194ef41feb1a42e 484 SUPERFAMILY SSF103473 262 478 2.09E-64 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS00635 ae5975e3006c62558ebbfe84964faa72 181 Gene3D G3DSA:3.40.50.300 10 132 4.8E-13 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS00635 ae5975e3006c62558ebbfe84964faa72 181 SUPERFAMILY SSF52540 11 146 8.64E-13 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS26750 615cdb4a6d8876141875e9d1dbafbe33 460 ProSitePatterns PS01148 Uncharacterized protein family UPF0033 signature. 391 415 - T 09-03-2017 IPR001455 TusA-like domain TK78_RS26750 615cdb4a6d8876141875e9d1dbafbe33 460 PIRSF PIRSF005572 1 373 1.6E-131 T 09-03-2017 IPR016454 Cysteine desulfurase KEGG: 00730+2.8.1.7|MetaCyc: PWY-6823|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7250 TK78_RS26750 615cdb4a6d8876141875e9d1dbafbe33 460 Gene3D G3DSA:3.90.1150.10 243 363 5.4E-32 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS26750 615cdb4a6d8876141875e9d1dbafbe33 460 Pfam PF00266 Aminotransferase class-V 3 358 7.0E-38 T 09-03-2017 IPR000192 Aminotransferase class V domain TK78_RS26750 615cdb4a6d8876141875e9d1dbafbe33 460 SUPERFAMILY SSF64307 388 458 2.35E-17 T 09-03-2017 IPR001455 TusA-like domain TK78_RS26750 615cdb4a6d8876141875e9d1dbafbe33 460 Gene3D G3DSA:3.40.640.10 14 242 7.5E-56 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS26750 615cdb4a6d8876141875e9d1dbafbe33 460 Pfam PF01206 Sulfurtransferase TusA 390 457 9.3E-16 T 09-03-2017 IPR001455 TusA-like domain TK78_RS26750 615cdb4a6d8876141875e9d1dbafbe33 460 Gene3D G3DSA:3.30.110.40 389 458 1.4E-20 T 09-03-2017 IPR001455 TusA-like domain TK78_RS26750 615cdb4a6d8876141875e9d1dbafbe33 460 SUPERFAMILY SSF53383 3 366 3.16E-76 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS33085 023ff3c0a36d92aab413d899301386f6 789 Gene3D G3DSA:2.60.200.20 135 217 2.2E-24 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS33085 023ff3c0a36d92aab413d899301386f6 789 Gene3D G3DSA:2.60.200.20 20 94 5.4E-19 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS33085 023ff3c0a36d92aab413d899301386f6 789 SUPERFAMILY SSF49879 114 237 2.49E-27 T 09-03-2017 IPR008984 SMAD/FHA domain GO:0005515 TK78_RS33085 023ff3c0a36d92aab413d899301386f6 789 Gene3D G3DSA:3.40.50.300 227 459 1.5E-67 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33085 023ff3c0a36d92aab413d899301386f6 789 ProSitePatterns PS00211 ABC transporters family signature. 371 385 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS33085 023ff3c0a36d92aab413d899301386f6 789 SMART SM00240 145 196 6.0E-16 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS33085 023ff3c0a36d92aab413d899301386f6 789 SMART SM00240 29 79 2.9E-10 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS33085 023ff3c0a36d92aab413d899301386f6 789 Pfam PF00005 ABC transporter 252 399 7.8E-32 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS33085 023ff3c0a36d92aab413d899301386f6 789 SMART SM00382 261 455 1.0E-11 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS33085 023ff3c0a36d92aab413d899301386f6 789 SUPERFAMILY SSF49879 6 96 2.87E-21 T 09-03-2017 IPR008984 SMAD/FHA domain GO:0005515 TK78_RS33085 023ff3c0a36d92aab413d899301386f6 789 Pfam PF00498 FHA domain 30 93 2.2E-14 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS33085 023ff3c0a36d92aab413d899301386f6 789 Pfam PF00498 FHA domain 146 210 7.3E-16 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS33085 023ff3c0a36d92aab413d899301386f6 789 SUPERFAMILY SSF52540 227 463 5.43E-59 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33085 023ff3c0a36d92aab413d899301386f6 789 Pfam PF01061 ABC-2 type transporter 525 732 5.8E-19 T 09-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 TK78_RS16820 3e6b170ff74676cf2021b08b83882166 196 Pfam PF00440 Bacterial regulatory proteins, tetR family 12 58 3.0E-12 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS16820 3e6b170ff74676cf2021b08b83882166 196 Gene3D G3DSA:1.10.357.10 10 193 2.1E-26 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS16820 3e6b170ff74676cf2021b08b83882166 196 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 12 25 6.1E-5 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS16820 3e6b170ff74676cf2021b08b83882166 196 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 33 56 6.1E-5 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS16820 3e6b170ff74676cf2021b08b83882166 196 SUPERFAMILY SSF46689 3 73 1.65E-14 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS17730 6865272c140d7ce8295f8f09c6ec43cb 484 Gene3D G3DSA:3.30.559.10 245 481 4.8E-83 T 09-03-2017 IPR023213 Chloramphenicol acetyltransferase-like domain Reactome: R-HSA-389661 TK78_RS17730 6865272c140d7ce8295f8f09c6ec43cb 484 Gene3D G3DSA:2.40.50.100 12 101 5.4E-27 T 09-03-2017 TK78_RS17730 6865272c140d7ce8295f8f09c6ec43cb 484 SUPERFAMILY SSF51230 11 103 4.06E-27 T 09-03-2017 IPR011053 Single hybrid motif TK78_RS17730 6865272c140d7ce8295f8f09c6ec43cb 484 SUPERFAMILY SSF52777 245 481 3.47E-76 T 09-03-2017 TK78_RS17730 6865272c140d7ce8295f8f09c6ec43cb 484 Pfam PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain) 253 481 4.9E-78 T 09-03-2017 IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 TK78_RS17730 6865272c140d7ce8295f8f09c6ec43cb 484 SUPERFAMILY SSF47005 178 220 2.09E-10 T 09-03-2017 IPR004167 E3-binding domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 TK78_RS17730 6865272c140d7ce8295f8f09c6ec43cb 484 Pfam PF02817 e3 binding domain 182 216 2.5E-13 T 09-03-2017 IPR004167 E3-binding domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 TK78_RS17730 6865272c140d7ce8295f8f09c6ec43cb 484 ProSitePatterns PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 36 65 - T 09-03-2017 IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site Reactome: R-HSA-389661 TK78_RS17730 6865272c140d7ce8295f8f09c6ec43cb 484 Pfam PF00364 Biotin-requiring enzyme 13 85 2.3E-23 T 09-03-2017 IPR000089 Biotin/lipoyl attachment TK78_RS17730 6865272c140d7ce8295f8f09c6ec43cb 484 Gene3D G3DSA:4.10.320.10 178 227 1.5E-16 T 09-03-2017 IPR004167 E3-binding domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 TK78_RS31195 89e71901315228b151f6fe19209e406f 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 175 192 3.0E-42 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS31195 89e71901315228b151f6fe19209e406f 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 215 235 3.0E-42 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS31195 89e71901315228b151f6fe19209e406f 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 129 145 3.0E-42 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS31195 89e71901315228b151f6fe19209e406f 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 82 93 3.0E-42 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS31195 89e71901315228b151f6fe19209e406f 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 154 173 3.0E-42 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS31195 89e71901315228b151f6fe19209e406f 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 3.0E-42 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS31195 89e71901315228b151f6fe19209e406f 253 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 13 250 3.5E-62 T 09-03-2017 TK78_RS31195 89e71901315228b151f6fe19209e406f 253 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 7 185 3.1E-5 T 09-03-2017 TK78_RS31195 89e71901315228b151f6fe19209e406f 253 SUPERFAMILY SSF51735 5 250 3.94E-79 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31195 89e71901315228b151f6fe19209e406f 253 Gene3D G3DSA:3.40.50.720 4 250 1.7E-81 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31195 89e71901315228b151f6fe19209e406f 253 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 135 143 1.9E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS31195 89e71901315228b151f6fe19209e406f 253 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 154 173 1.9E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS31195 89e71901315228b151f6fe19209e406f 253 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 82 93 1.9E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS18915 12b5809f9179b87cfb157feac6e6251b 225 SUPERFAMILY SSF46689 26 97 7.48E-17 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS18915 12b5809f9179b87cfb157feac6e6251b 225 Pfam PF00440 Bacterial regulatory proteins, tetR family 41 83 5.5E-15 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS18915 12b5809f9179b87cfb157feac6e6251b 225 Gene3D G3DSA:1.10.10.60 28 80 4.0E-18 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS18915 12b5809f9179b87cfb157feac6e6251b 225 Gene3D G3DSA:1.10.357.10 81 213 1.2E-14 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS18915 12b5809f9179b87cfb157feac6e6251b 225 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 39 52 1.6E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS18915 12b5809f9179b87cfb157feac6e6251b 225 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 60 83 1.6E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS18915 12b5809f9179b87cfb157feac6e6251b 225 ProSitePatterns PS01081 TetR-type HTH domain signature. 51 82 - T 09-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site TK78_RS22690 9ae2a61b3b8ae45b3cdf91a593f21a32 498 ProSitePatterns PS00216 Sugar transport proteins signature 1. 340 356 - T 09-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 TK78_RS22690 9ae2a61b3b8ae45b3cdf91a593f21a32 498 Gene3D G3DSA:1.20.1250.20 47 254 1.0E-26 T 09-03-2017 TK78_RS22690 9ae2a61b3b8ae45b3cdf91a593f21a32 498 Gene3D G3DSA:1.20.1250.20 283 469 3.9E-23 T 09-03-2017 TK78_RS22690 9ae2a61b3b8ae45b3cdf91a593f21a32 498 SUPERFAMILY SSF103473 47 472 6.02E-73 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS22690 9ae2a61b3b8ae45b3cdf91a593f21a32 498 ProSitePatterns PS00217 Sugar transport proteins signature 2. 159 184 - T 09-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 TK78_RS22690 9ae2a61b3b8ae45b3cdf91a593f21a32 498 Pfam PF00083 Sugar (and other) transporter 53 473 3.1E-45 T 09-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 TK78_RS25105 228559b0179df86ab28599b05312487f 141 Gene3D G3DSA:3.10.180.10 1 140 4.8E-45 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS25105 228559b0179df86ab28599b05312487f 141 Pfam PF13669 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 4 114 1.3E-10 T 09-03-2017 TK78_RS25105 228559b0179df86ab28599b05312487f 141 SUPERFAMILY SSF54593 1 138 8.53E-29 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS32335 39e400ff03d19a0438d2dd57a7bf51ff 574 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 246 393 1.3E-17 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS32335 39e400ff03d19a0438d2dd57a7bf51ff 574 Gene3D G3DSA:2.40.110.10 137 232 1.0E-9 T 09-03-2017 TK78_RS32335 39e400ff03d19a0438d2dd57a7bf51ff 574 SUPERFAMILY SSF47203 245 400 1.55E-25 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS32335 39e400ff03d19a0438d2dd57a7bf51ff 574 Gene3D G3DSA:1.20.140.10 233 395 2.1E-20 T 09-03-2017 TK78_RS32335 39e400ff03d19a0438d2dd57a7bf51ff 574 SUPERFAMILY SSF56645 18 215 9.16E-24 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS07820 7f28c555adac03995e9fbc2fa185bb27 1033 Gene3D G3DSA:2.40.30.10 702 796 1.7E-22 T 09-03-2017 TK78_RS07820 7f28c555adac03995e9fbc2fa185bb27 1033 SUPERFAMILY SSF50447 934 1032 3.12E-25 T 09-03-2017 IPR009000 Translation protein, beta-barrel domain TK78_RS07820 7f28c555adac03995e9fbc2fa185bb27 1033 SUPERFAMILY SSF50447 703 787 3.53E-24 T 09-03-2017 IPR009000 Translation protein, beta-barrel domain TK78_RS07820 7f28c555adac03995e9fbc2fa185bb27 1033 PRINTS PR00315 GTP-binding elongation factor signature 598 609 1.2E-9 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS07820 7f28c555adac03995e9fbc2fa185bb27 1033 PRINTS PR00315 GTP-binding elongation factor signature 634 643 1.2E-9 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS07820 7f28c555adac03995e9fbc2fa185bb27 1033 PRINTS PR00315 GTP-binding elongation factor signature 530 543 1.2E-9 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS07820 7f28c555adac03995e9fbc2fa185bb27 1033 PRINTS PR00315 GTP-binding elongation factor signature 582 592 1.2E-9 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS07820 7f28c555adac03995e9fbc2fa185bb27 1033 SUPERFAMILY SSF52156 813 940 8.37E-35 T 09-03-2017 IPR023115 Translation initiation factor IF- 2, domain 3 TK78_RS07820 7f28c555adac03995e9fbc2fa185bb27 1033 Gene3D G3DSA:3.40.50.300 526 690 1.5E-46 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07820 7f28c555adac03995e9fbc2fa185bb27 1033 SMART SM00173 553 696 0.01 T 09-03-2017 TK78_RS07820 7f28c555adac03995e9fbc2fa185bb27 1033 Gene3D G3DSA:2.40.30.10 935 1032 2.7E-30 T 09-03-2017 TK78_RS07820 7f28c555adac03995e9fbc2fa185bb27 1033 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 528 688 1.8E-30 T 09-03-2017 IPR005225 Small GTP-binding protein domain GO:0005525 TK78_RS07820 7f28c555adac03995e9fbc2fa185bb27 1033 Hamap MF_00100_B Translation initiation factor IF-2 [infB]. 3 1032 16.656 T 09-03-2017 IPR000178 Translation initiation factor aIF-2, bacterial-like GO:0003743|GO:0005525|GO:0005622|GO:0006413 Reactome: R-HSA-5368286 TK78_RS07820 7f28c555adac03995e9fbc2fa185bb27 1033 Pfam PF04760 Translation initiation factor IF-2, N-terminal region 447 492 4.4E-7 T 09-03-2017 IPR006847 Translation initiation factor IF-2, N-terminal TK78_RS07820 7f28c555adac03995e9fbc2fa185bb27 1033 Pfam PF04760 Translation initiation factor IF-2, N-terminal region 2 50 5.7E-12 T 09-03-2017 IPR006847 Translation initiation factor IF-2, N-terminal TK78_RS07820 7f28c555adac03995e9fbc2fa185bb27 1033 Pfam PF11987 Translation-initiation factor 2 818 923 3.0E-34 T 09-03-2017 IPR023115 Translation initiation factor IF- 2, domain 3 TK78_RS07820 7f28c555adac03995e9fbc2fa185bb27 1033 ProSitePatterns PS01176 Initiation factor 2 signature. 985 1007 - T 09-03-2017 IPR000178 Translation initiation factor aIF-2, bacterial-like GO:0003743|GO:0005525|GO:0005622|GO:0006413 Reactome: R-HSA-5368286 TK78_RS07820 7f28c555adac03995e9fbc2fa185bb27 1033 SUPERFAMILY SSF52540 524 693 1.17E-47 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07820 7f28c555adac03995e9fbc2fa185bb27 1033 Gene3D G3DSA:3.40.50.10050 832 912 4.7E-23 T 09-03-2017 IPR023115 Translation initiation factor IF- 2, domain 3 TK78_RS07820 7f28c555adac03995e9fbc2fa185bb27 1033 TIGRFAM TIGR00487 IF-2: translation initiation factor IF-2 440 1032 1.4E-227 T 09-03-2017 IPR000178 Translation initiation factor aIF-2, bacterial-like GO:0003743|GO:0005525|GO:0005622|GO:0006413 Reactome: R-HSA-5368286 TK78_RS07820 7f28c555adac03995e9fbc2fa185bb27 1033 Pfam PF00009 Elongation factor Tu GTP binding domain 531 691 1.0E-33 T 09-03-2017 TK78_RS26285 ca6e74c705a04274cdec2341dded6f11 424 Pfam PF04607 Region found in RelA / SpoT proteins 44 174 3.4E-17 T 09-03-2017 IPR007685 RelA/SpoT GO:0015969 TK78_RS26285 ca6e74c705a04274cdec2341dded6f11 424 Gene3D G3DSA:3.30.460.10 7 157 1.4E-16 T 09-03-2017 TK78_RS26285 ca6e74c705a04274cdec2341dded6f11 424 SMART SM00954 44 179 7.8E-9 T 09-03-2017 IPR007685 RelA/SpoT GO:0015969 TK78_RS26285 ca6e74c705a04274cdec2341dded6f11 424 SUPERFAMILY SSF81301 7 203 6.21E-27 T 09-03-2017 TK78_RS30285 c8011fbc95b63b9eeaf1cbad78aba4c5 143 Hamap MF_00073 N utilization substance protein B homolog [nusB]. 2 137 22.453 T 09-03-2017 IPR011605 NusB antitermination factor GO:0006353 TK78_RS30285 c8011fbc95b63b9eeaf1cbad78aba4c5 143 Gene3D G3DSA:1.10.940.10 2 132 3.3E-43 T 09-03-2017 IPR006027 NusB/RsmB/TIM44 GO:0003723|GO:0006355 TK78_RS30285 c8011fbc95b63b9eeaf1cbad78aba4c5 143 Pfam PF01029 NusB family 6 133 7.1E-35 T 09-03-2017 IPR006027 NusB/RsmB/TIM44 GO:0003723|GO:0006355 TK78_RS30285 c8011fbc95b63b9eeaf1cbad78aba4c5 143 TIGRFAM TIGR01951 nusB: transcription antitermination factor NusB 4 134 2.9E-40 T 09-03-2017 IPR011605 NusB antitermination factor GO:0006353 TK78_RS30285 c8011fbc95b63b9eeaf1cbad78aba4c5 143 SUPERFAMILY SSF48013 4 131 2.49E-39 T 09-03-2017 IPR006027 NusB/RsmB/TIM44 GO:0003723|GO:0006355 TK78_RS31965 e19bcfc80c1bc846a49b267d9288428a 532 Pfam PF00171 Aldehyde dehydrogenase family 40 496 6.0E-140 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS31965 e19bcfc80c1bc846a49b267d9288428a 532 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 268 275 - T 09-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 TK78_RS31965 e19bcfc80c1bc846a49b267d9288428a 532 Gene3D G3DSA:3.40.605.10 38 282 2.3E-73 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS31965 e19bcfc80c1bc846a49b267d9288428a 532 SUPERFAMILY SSF53720 38 498 4.19E-141 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS31965 e19bcfc80c1bc846a49b267d9288428a 532 Gene3D G3DSA:3.40.309.10 283 460 4.6E-63 T 09-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 TK78_RS26640 6def9412767b38d4e3024cc526be8596 515 Gene3D G3DSA:3.40.220.10 16 189 4.5E-40 T 09-03-2017 TK78_RS26640 6def9412767b38d4e3024cc526be8596 515 Pfam PF02789 Cytosol aminopeptidase family, N-terminal domain 20 144 1.3E-24 T 09-03-2017 IPR008283 Peptidase M17, leucyl aminopeptidase, N-terminal GO:0004177|GO:0005622|GO:0006508 KEGG: 00480+3.4.11.1 TK78_RS26640 6def9412767b38d4e3024cc526be8596 515 SUPERFAMILY SSF53187 191 508 2.09E-114 T 09-03-2017 TK78_RS26640 6def9412767b38d4e3024cc526be8596 515 ProSitePatterns PS00631 Cytosol aminopeptidase signature. 357 364 - T 09-03-2017 IPR000819 Peptidase M17, leucyl aminopeptidase, C-terminal GO:0004177|GO:0005622|GO:0006508 KEGG: 00480+3.4.11.1 TK78_RS26640 6def9412767b38d4e3024cc526be8596 515 PRINTS PR00481 Cytosol aminopeptidase signature 272 289 1.7E-49 T 09-03-2017 IPR011356 Peptidase M17, leucine aminopeptidase/peptidase B GO:0004177|GO:0005737|GO:0008235|GO:0019538|GO:0030145 KEGG: 00480+3.4.11.1 TK78_RS26640 6def9412767b38d4e3024cc526be8596 515 PRINTS PR00481 Cytosol aminopeptidase signature 331 352 1.7E-49 T 09-03-2017 IPR011356 Peptidase M17, leucine aminopeptidase/peptidase B GO:0004177|GO:0005737|GO:0008235|GO:0019538|GO:0030145 KEGG: 00480+3.4.11.1 TK78_RS26640 6def9412767b38d4e3024cc526be8596 515 PRINTS PR00481 Cytosol aminopeptidase signature 381 396 1.7E-49 T 09-03-2017 IPR011356 Peptidase M17, leucine aminopeptidase/peptidase B GO:0004177|GO:0005737|GO:0008235|GO:0019538|GO:0030145 KEGG: 00480+3.4.11.1 TK78_RS26640 6def9412767b38d4e3024cc526be8596 515 PRINTS PR00481 Cytosol aminopeptidase signature 294 315 1.7E-49 T 09-03-2017 IPR011356 Peptidase M17, leucine aminopeptidase/peptidase B GO:0004177|GO:0005737|GO:0008235|GO:0019538|GO:0030145 KEGG: 00480+3.4.11.1 TK78_RS26640 6def9412767b38d4e3024cc526be8596 515 PRINTS PR00481 Cytosol aminopeptidase signature 353 373 1.7E-49 T 09-03-2017 IPR011356 Peptidase M17, leucine aminopeptidase/peptidase B GO:0004177|GO:0005737|GO:0008235|GO:0019538|GO:0030145 KEGG: 00480+3.4.11.1 TK78_RS26640 6def9412767b38d4e3024cc526be8596 515 Hamap MF_00181 Probable cytosol aminopeptidase [pepA]. 4 511 33.934 T 09-03-2017 IPR023042 Peptidase M17, leucine aminopeptidase KEGG: 00480+3.4.11.1 TK78_RS26640 6def9412767b38d4e3024cc526be8596 515 SUPERFAMILY SSF52949 17 149 8.24E-24 T 09-03-2017 TK78_RS26640 6def9412767b38d4e3024cc526be8596 515 Pfam PF00883 Cytosol aminopeptidase family, catalytic domain 197 503 7.8E-116 T 09-03-2017 IPR000819 Peptidase M17, leucyl aminopeptidase, C-terminal GO:0004177|GO:0005622|GO:0006508 KEGG: 00480+3.4.11.1 TK78_RS26640 6def9412767b38d4e3024cc526be8596 515 Gene3D G3DSA:3.40.630.10 190 509 2.6E-131 T 09-03-2017 TK78_RS30695 e410defb7bb7f9e2062c67340e4b86fe 268 Pfam PF01427 D-ala-D-ala dipeptidase 39 162 5.3E-16 T 09-03-2017 IPR000755 D-alanyl-D-alanine dipeptidase GO:0005618|GO:0006508|GO:0008237|GO:0016805 MetaCyc: PWY-6454|MetaCyc: PWY-6455 TK78_RS30695 e410defb7bb7f9e2062c67340e4b86fe 268 Pfam PF01427 D-ala-D-ala dipeptidase 192 260 3.4E-13 T 09-03-2017 IPR000755 D-alanyl-D-alanine dipeptidase GO:0005618|GO:0006508|GO:0008237|GO:0016805 MetaCyc: PWY-6454|MetaCyc: PWY-6455 TK78_RS30695 e410defb7bb7f9e2062c67340e4b86fe 268 Hamap MF_01924 D-alanyl-D-alanine dipeptidase [ddpX]. 39 259 30.755 T 09-03-2017 IPR000755 D-alanyl-D-alanine dipeptidase GO:0005618|GO:0006508|GO:0008237|GO:0016805 MetaCyc: PWY-6454|MetaCyc: PWY-6455 TK78_RS30695 e410defb7bb7f9e2062c67340e4b86fe 268 Gene3D G3DSA:3.30.1380.10 37 260 4.2E-72 T 09-03-2017 IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain Reactome: R-HSA-373080|Reactome: R-HSA-5358346|Reactome: R-HSA-5362798|Reactome: R-HSA-5632681|Reactome: R-HSA-5658034 TK78_RS30695 e410defb7bb7f9e2062c67340e4b86fe 268 SUPERFAMILY SSF55166 37 260 2.04E-60 T 09-03-2017 IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain Reactome: R-HSA-373080|Reactome: R-HSA-5358346|Reactome: R-HSA-5362798|Reactome: R-HSA-5632681|Reactome: R-HSA-5658034 TK78_RS30695 e410defb7bb7f9e2062c67340e4b86fe 268 PIRSF PIRSF026671 10 265 1.2E-73 T 09-03-2017 IPR000755 D-alanyl-D-alanine dipeptidase GO:0005618|GO:0006508|GO:0008237|GO:0016805 MetaCyc: PWY-6454|MetaCyc: PWY-6455 TK78_RS07550 6c5451351d7a599eb492d4843231fd65 254 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 17 249 1.3E-60 T 09-03-2017 TK78_RS07550 6c5451351d7a599eb492d4843231fd65 254 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 143 171 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS07550 6c5451351d7a599eb492d4843231fd65 254 SUPERFAMILY SSF51735 10 249 3.45E-75 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07550 6c5451351d7a599eb492d4843231fd65 254 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 82 93 3.0E-8 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS07550 6c5451351d7a599eb492d4843231fd65 254 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 156 175 3.0E-8 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS07550 6c5451351d7a599eb492d4843231fd65 254 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 136 144 3.0E-8 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS07550 6c5451351d7a599eb492d4843231fd65 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 12 29 3.7E-40 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS07550 6c5451351d7a599eb492d4843231fd65 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 156 175 3.7E-40 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS07550 6c5451351d7a599eb492d4843231fd65 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 214 234 3.7E-40 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS07550 6c5451351d7a599eb492d4843231fd65 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 130 146 3.7E-40 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS07550 6c5451351d7a599eb492d4843231fd65 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 82 93 3.7E-40 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS07550 6c5451351d7a599eb492d4843231fd65 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 177 194 3.7E-40 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS07550 6c5451351d7a599eb492d4843231fd65 254 Gene3D G3DSA:3.40.50.720 5 249 1.7E-78 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS21485 15d4d1cee8f35570a3b22a9a3df51f5a 289 SUPERFAMILY SSF81301 28 145 2.29E-7 T 09-03-2017 TK78_RS21485 15d4d1cee8f35570a3b22a9a3df51f5a 289 Gene3D G3DSA:3.30.460.10 36 146 6.1E-6 T 09-03-2017 TK78_RS10305 480b025b7e3854cc523e61804655a5b5 741 Pfam PF13722 5TM C-terminal transporter carbon starvation CstA 482 609 6.2E-34 T 09-03-2017 IPR025299 CstA, C-terminal domain TK78_RS10305 480b025b7e3854cc523e61804655a5b5 741 Pfam PF02554 Carbon starvation protein CstA 50 426 6.2E-167 T 09-03-2017 IPR003706 CstA, N-terminal domain GO:0009267|GO:0016020 TK78_RS05670 509049adecfaae09781faae89880b325 377 PIRSF PIRSF001092 1 364 5.2E-61 T 09-03-2017 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 TK78_RS05670 509049adecfaae09781faae89880b325 377 SUPERFAMILY SSF51445 5 240 1.16E-71 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS05670 509049adecfaae09781faae89880b325 377 SUPERFAMILY SSF51445 283 363 1.16E-71 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS05670 509049adecfaae09781faae89880b325 377 Gene3D G3DSA:3.20.20.80 281 364 1.1E-81 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS05670 509049adecfaae09781faae89880b325 377 Gene3D G3DSA:3.20.20.80 5 246 1.1E-81 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS05670 509049adecfaae09781faae89880b325 377 Pfam PF01120 Alpha-L-fucosidase 4 360 2.0E-57 T 09-03-2017 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 TK78_RS05670 509049adecfaae09781faae89880b325 377 PRINTS PR00741 Glycosyl hydrolase family 29 signature 197 213 3.0E-7 T 09-03-2017 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 TK78_RS05670 509049adecfaae09781faae89880b325 377 PRINTS PR00741 Glycosyl hydrolase family 29 signature 108 124 3.0E-7 T 09-03-2017 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 TK78_RS05670 509049adecfaae09781faae89880b325 377 SMART SM00812 2 374 2.5E-38 T 09-03-2017 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 TK78_RS10790 c97ac0f70218b5f9faea16dbe64e8cf1 221 SUPERFAMILY SSF53335 36 220 8.76E-35 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS10790 c97ac0f70218b5f9faea16dbe64e8cf1 221 Gene3D G3DSA:3.40.50.150 23 220 3.9E-52 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS10790 c97ac0f70218b5f9faea16dbe64e8cf1 221 Pfam PF01596 O-methyltransferase 46 218 1.8E-20 T 09-03-2017 IPR002935 O-methyltransferase, family 3 GO:0008171 TK78_RS24400 633f710c80b2ae7b4753fe01c1a7bce4 466 SUPERFAMILY SSF109998 245 434 9.29E-38 T 09-03-2017 IPR027304 Trigger factor/SurA domain TK78_RS24400 633f710c80b2ae7b4753fe01c1a7bce4 466 Hamap MF_00303 Trigger factor [tig]. 1 425 19.275 T 09-03-2017 IPR005215 Trigger factor GO:0015031 TK78_RS24400 633f710c80b2ae7b4753fe01c1a7bce4 466 SUPERFAMILY SSF102735 3 129 3.4E-37 T 09-03-2017 IPR008881 Trigger factor, ribosome-binding, bacterial GO:0006457|GO:0015031 TK78_RS24400 633f710c80b2ae7b4753fe01c1a7bce4 466 PIRSF PIRSF003095 1 446 2.5E-122 T 09-03-2017 IPR005215 Trigger factor GO:0015031 TK78_RS24400 633f710c80b2ae7b4753fe01c1a7bce4 466 SUPERFAMILY SSF54534 133 244 7.07E-21 T 09-03-2017 TK78_RS24400 633f710c80b2ae7b4753fe01c1a7bce4 466 Pfam PF05698 Bacterial trigger factor protein (TF) C-terminus 258 420 3.1E-36 T 09-03-2017 IPR008880 Trigger factor, C-terminal GO:0006457|GO:0015031 TK78_RS24400 633f710c80b2ae7b4753fe01c1a7bce4 466 Pfam PF05697 Bacterial trigger factor protein (TF) 3 145 1.2E-41 T 09-03-2017 IPR008881 Trigger factor, ribosome-binding, bacterial GO:0006457|GO:0015031 TK78_RS24400 633f710c80b2ae7b4753fe01c1a7bce4 466 Gene3D G3DSA:1.10.3120.10 211 394 1.1E-43 T 09-03-2017 IPR008880 Trigger factor, C-terminal GO:0006457|GO:0015031 TK78_RS24400 633f710c80b2ae7b4753fe01c1a7bce4 466 Pfam PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 157 215 2.2E-7 T 09-03-2017 IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain GO:0006457 TK78_RS24400 633f710c80b2ae7b4753fe01c1a7bce4 466 Gene3D G3DSA:3.30.70.1050 3 119 2.0E-35 T 09-03-2017 IPR008881 Trigger factor, ribosome-binding, bacterial GO:0006457|GO:0015031 TK78_RS24400 633f710c80b2ae7b4753fe01c1a7bce4 466 TIGRFAM TIGR00115 tig: trigger factor 12 418 3.1E-120 T 09-03-2017 IPR005215 Trigger factor GO:0015031 TK78_RS24400 633f710c80b2ae7b4753fe01c1a7bce4 466 Gene3D G3DSA:3.10.50.40 157 210 4.1E-6 T 09-03-2017 TK78_RS26800 766f24a421aa5154a52e14b1603b6868 354 Pfam PF00591 Glycosyl transferase family, a/b domain 88 341 4.2E-78 T 09-03-2017 IPR000312 Glycosyl transferase, family 3 GO:0008152|GO:0016757 Reactome: R-HSA-73614|Reactome: R-HSA-73621 TK78_RS26800 766f24a421aa5154a52e14b1603b6868 354 SUPERFAMILY SSF47648 16 83 3.27E-21 T 09-03-2017 IPR017459 Glycosyl transferase family 3, N-terminal domain Reactome: R-HSA-73614|Reactome: R-HSA-73621 TK78_RS26800 766f24a421aa5154a52e14b1603b6868 354 Hamap MF_00211 Anthranilate phosphoribosyltransferase [trpD]. 19 351 35.105 T 09-03-2017 IPR005940 Anthranilate phosphoribosyl transferase GO:0000162|GO:0004048 KEGG: 00400+2.4.2.18 TK78_RS26800 766f24a421aa5154a52e14b1603b6868 354 Gene3D G3DSA:1.20.970.10 16 80 1.1E-26 T 09-03-2017 TK78_RS26800 766f24a421aa5154a52e14b1603b6868 354 Pfam PF02885 Glycosyl transferase family, helical bundle domain 21 80 9.2E-21 T 09-03-2017 IPR017459 Glycosyl transferase family 3, N-terminal domain Reactome: R-HSA-73614|Reactome: R-HSA-73621 TK78_RS26800 766f24a421aa5154a52e14b1603b6868 354 TIGRFAM TIGR01245 trpD: anthranilate phosphoribosyltransferase 23 350 1.3E-107 T 09-03-2017 IPR005940 Anthranilate phosphoribosyl transferase GO:0000162|GO:0004048 KEGG: 00400+2.4.2.18 TK78_RS26800 766f24a421aa5154a52e14b1603b6868 354 SUPERFAMILY SSF52418 87 353 1.02E-78 T 09-03-2017 IPR000312 Glycosyl transferase, family 3 GO:0008152|GO:0016757 Reactome: R-HSA-73614|Reactome: R-HSA-73621 TK78_RS26800 766f24a421aa5154a52e14b1603b6868 354 Gene3D G3DSA:3.40.1030.10 86 353 8.4E-101 T 09-03-2017 IPR000312 Glycosyl transferase, family 3 GO:0008152|GO:0016757 Reactome: R-HSA-73614|Reactome: R-HSA-73621 TK78_RS15635 bc7b73324de0fb4edcaf1fc2baa9f546 162 SUPERFAMILY SSF56524 15 160 7.06E-18 T 09-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 TK78_RS15635 bc7b73324de0fb4edcaf1fc2baa9f546 162 Gene3D G3DSA:3.90.420.10 16 152 4.5E-11 T 09-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 TK78_RS15635 bc7b73324de0fb4edcaf1fc2baa9f546 162 Pfam PF00174 Oxidoreductase molybdopterin binding domain 16 153 7.0E-8 T 09-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 TK78_RS08810 dd4767d08db7bb383b2baacb4f47870a 1048 SUPERFAMILY SSF52540 30 93 5.86E-14 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08810 dd4767d08db7bb383b2baacb4f47870a 1048 SUPERFAMILY SSF52540 143 283 5.86E-14 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08810 dd4767d08db7bb383b2baacb4f47870a 1048 Gene3D G3DSA:1.10.10.10 982 1044 1.1E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS08810 dd4767d08db7bb383b2baacb4f47870a 1048 Pfam PF00196 Bacterial regulatory proteins, luxR family 985 1039 1.4E-17 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS08810 dd4767d08db7bb383b2baacb4f47870a 1048 SMART SM00421 982 1039 1.1E-23 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS08810 dd4767d08db7bb383b2baacb4f47870a 1048 Gene3D G3DSA:3.40.50.300 30 90 6.9E-11 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08810 dd4767d08db7bb383b2baacb4f47870a 1048 Gene3D G3DSA:3.40.50.300 141 224 6.9E-11 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08810 dd4767d08db7bb383b2baacb4f47870a 1048 Pfam PF13191 AAA ATPase domain 30 200 1.7E-32 T 09-03-2017 TK78_RS08810 dd4767d08db7bb383b2baacb4f47870a 1048 SUPERFAMILY SSF46894 975 1045 1.8E-20 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS08810 dd4767d08db7bb383b2baacb4f47870a 1048 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 1015 1027 6.5E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS08810 dd4767d08db7bb383b2baacb4f47870a 1048 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 999 1015 6.5E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS08810 dd4767d08db7bb383b2baacb4f47870a 1048 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 985 999 6.5E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS30600 fb5c0d938164ac284e954e25712a54c2 556 Gene3D G3DSA:3.40.50.300 255 477 6.6E-24 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS30600 fb5c0d938164ac284e954e25712a54c2 556 SUPERFAMILY SSF52540 245 481 2.72E-17 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06245 7db58bbafa47523498a2ed3e29023ca1 521 Pfam PF13520 Amino acid permease 37 478 3.1E-41 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS06245 7db58bbafa47523498a2ed3e29023ca1 521 PIRSF PIRSF006060 14 517 7.5E-63 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS08370 f58e5728dc4adbc0dd5e2572043c97a3 238 SMART SM00346 7 93 1.2E-14 T 09-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 TK78_RS08370 f58e5728dc4adbc0dd5e2572043c97a3 238 SUPERFAMILY SSF46785 7 75 1.36E-10 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS08370 f58e5728dc4adbc0dd5e2572043c97a3 238 Gene3D G3DSA:3.30.450.40 74 234 8.4E-39 T 09-03-2017 IPR029016 GAF domain-like TK78_RS08370 f58e5728dc4adbc0dd5e2572043c97a3 238 Pfam PF09339 IclR helix-turn-helix domain 10 57 1.5E-9 T 09-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 TK78_RS08370 f58e5728dc4adbc0dd5e2572043c97a3 238 SUPERFAMILY SSF55781 62 234 2.88E-33 T 09-03-2017 IPR029016 GAF domain-like TK78_RS08370 f58e5728dc4adbc0dd5e2572043c97a3 238 Gene3D G3DSA:1.10.10.10 3 73 3.2E-16 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS08370 f58e5728dc4adbc0dd5e2572043c97a3 238 Pfam PF01614 Bacterial transcriptional regulator 125 230 1.2E-15 T 09-03-2017 IPR014757 Transcription regulator IclR, C-terminal TK78_RS22655 66dad2d9bd346ab968c42090dbae3a03 77 TIGRFAM TIGR00826 EIIB_glc: PTS system, glucose-like IIB component 3 63 8.9E-18 T 09-03-2017 IPR001996 Phosphotransferase system, IIB component, type 1 GO:0008982|GO:0009401 TK78_RS22655 66dad2d9bd346ab968c42090dbae3a03 77 SUPERFAMILY SSF55604 5 76 3.01E-21 T 09-03-2017 IPR001996 Phosphotransferase system, IIB component, type 1 GO:0008982|GO:0009401 TK78_RS22655 66dad2d9bd346ab968c42090dbae3a03 77 Gene3D G3DSA:3.30.1360.60 3 77 1.0E-27 T 09-03-2017 IPR001996 Phosphotransferase system, IIB component, type 1 GO:0008982|GO:0009401 TK78_RS22655 66dad2d9bd346ab968c42090dbae3a03 77 Pfam PF00367 phosphotransferase system, EIIB 7 39 1.5E-13 T 09-03-2017 IPR018113 Phosphotransferase system EIIB, cysteine phosphorylation site GO:0008982 TK78_RS04340 d5cff2ac4dd4ebba4de7171ad83aeb90 549 SMART SM00331 326 545 7.0E-21 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS04340 d5cff2ac4dd4ebba4de7171ad83aeb90 549 SUPERFAMILY SSF81606 341 542 8.11E-5 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS04340 d5cff2ac4dd4ebba4de7171ad83aeb90 549 Gene3D G3DSA:3.30.450.40 136 292 4.2E-9 T 09-03-2017 IPR029016 GAF domain-like TK78_RS04340 d5cff2ac4dd4ebba4de7171ad83aeb90 549 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 354 544 1.3E-30 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS04340 d5cff2ac4dd4ebba4de7171ad83aeb90 549 SUPERFAMILY SSF55785 6 117 2.44E-8 T 09-03-2017 IPR000014 PAS domain TK78_RS04340 d5cff2ac4dd4ebba4de7171ad83aeb90 549 Gene3D G3DSA:3.30.450.20 7 117 2.8E-10 T 09-03-2017 TK78_RS21030 c8e167c29814831d277dc04fc94c1cbc 190 Pfam PF16859 Bacterial transcriptional repressor C-terminal 72 183 7.5E-29 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS21030 c8e167c29814831d277dc04fc94c1cbc 190 SUPERFAMILY SSF48498 75 186 2.16E-18 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS21030 c8e167c29814831d277dc04fc94c1cbc 190 SUPERFAMILY SSF46689 2 63 5.99E-13 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS21030 c8e167c29814831d277dc04fc94c1cbc 190 Gene3D G3DSA:1.10.357.10 56 187 2.7E-26 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS21030 c8e167c29814831d277dc04fc94c1cbc 190 Gene3D G3DSA:1.10.10.60 3 55 5.4E-16 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS21030 c8e167c29814831d277dc04fc94c1cbc 190 Pfam PF00440 Bacterial regulatory proteins, tetR family 16 58 1.0E-10 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS16410 640633c9ed79550a492b5bc39a53bec2 67 SUPERFAMILY SSF50249 1 66 2.57E-25 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS16410 640633c9ed79550a492b5bc39a53bec2 67 PRINTS PR00050 Cold shock protein signature 40 58 5.0E-18 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS16410 640633c9ed79550a492b5bc39a53bec2 67 PRINTS PR00050 Cold shock protein signature 4 19 5.0E-18 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS16410 640633c9ed79550a492b5bc39a53bec2 67 PRINTS PR00050 Cold shock protein signature 25 34 5.0E-18 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS16410 640633c9ed79550a492b5bc39a53bec2 67 PIRSF PIRSF002599 1 67 1.4E-26 T 09-03-2017 IPR012156 Cold shock, CspA GO:0003676 TK78_RS16410 640633c9ed79550a492b5bc39a53bec2 67 SMART SM00357 3 67 6.4E-32 T 09-03-2017 IPR011129 Cold shock protein GO:0003676 TK78_RS16410 640633c9ed79550a492b5bc39a53bec2 67 Gene3D G3DSA:2.40.50.140 1 65 4.6E-31 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS16410 640633c9ed79550a492b5bc39a53bec2 67 Pfam PF00313 'Cold-shock' DNA-binding domain 3 65 1.2E-31 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS16410 640633c9ed79550a492b5bc39a53bec2 67 ProSitePatterns PS00352 'Cold-shock' domain signature. 15 34 - T 09-03-2017 IPR019844 Cold-shock conserved site TK78_RS30755 2824827e345390148830669916ec6cfc 831 Gene3D G3DSA:3.90.550.10 1 237 3.4E-77 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS30755 2824827e345390148830669916ec6cfc 831 SUPERFAMILY SSF55957 744 828 2.07E-12 T 09-03-2017 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS30755 2824827e345390148830669916ec6cfc 831 Gene3D G3DSA:3.40.120.10 552 628 9.0E-12 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS30755 2824827e345390148830669916ec6cfc 831 SUPERFAMILY SSF51161 244 433 2.94E-32 T 09-03-2017 IPR011004 Trimeric LpxA-like TK78_RS30755 2824827e345390148830669916ec6cfc 831 Gene3D G3DSA:3.30.310.50 752 828 9.4E-12 T 09-03-2017 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS30755 2824827e345390148830669916ec6cfc 831 Pfam PF02878 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I 384 511 3.3E-15 T 09-03-2017 IPR005844 Alpha-D-phosphohexomutase, alpha/beta/alpha domain I GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS30755 2824827e345390148830669916ec6cfc 831 Gene3D G3DSA:3.40.120.10 384 511 1.3E-13 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS30755 2824827e345390148830669916ec6cfc 831 Pfam PF00483 Nucleotidyl transferase 2 234 6.2E-54 T 09-03-2017 IPR005835 Nucleotidyl transferase domain GO:0009058|GO:0016779 TK78_RS30755 2824827e345390148830669916ec6cfc 831 SUPERFAMILY SSF53738 530 634 9.42E-13 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS30755 2824827e345390148830669916ec6cfc 831 SUPERFAMILY SSF53448 269 325 1.08E-80 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS30755 2824827e345390148830669916ec6cfc 831 SUPERFAMILY SSF53448 1 237 1.08E-80 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS30755 2824827e345390148830669916ec6cfc 831 Gene3D G3DSA:2.160.10.10 238 366 2.3E-26 T 09-03-2017 TK78_RS30755 2824827e345390148830669916ec6cfc 831 Pfam PF02879 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II 532 632 3.7E-16 T 09-03-2017 IPR005845 Alpha-D-phosphohexomutase, alpha/beta/alpha domain II GO:0005975 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS30755 2824827e345390148830669916ec6cfc 831 SUPERFAMILY SSF53738 637 741 1.22E-12 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS30755 2824827e345390148830669916ec6cfc 831 Pfam PF02880 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III 640 740 2.4E-5 T 09-03-2017 IPR005846 Alpha-D-phosphohexomutase, alpha/beta/alpha domain III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS30755 2824827e345390148830669916ec6cfc 831 Gene3D G3DSA:3.40.120.10 633 726 3.5E-14 T 09-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TK78_RS12835 f8b9bb34df2018c0f0819f7358c91178 215 SUPERFAMILY SSF53067 1 97 4.19E-20 T 09-03-2017 TK78_RS12835 f8b9bb34df2018c0f0819f7358c91178 215 SUPERFAMILY SSF53067 105 197 2.46E-11 T 09-03-2017 TK78_RS12835 f8b9bb34df2018c0f0819f7358c91178 215 Gene3D G3DSA:3.30.420.40 1 125 2.4E-35 T 09-03-2017 TK78_RS12835 f8b9bb34df2018c0f0819f7358c91178 215 Pfam PF00814 Glycoprotease family 27 142 4.3E-29 T 09-03-2017 IPR000905 Gcp-like domain KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 TK78_RS12835 f8b9bb34df2018c0f0819f7358c91178 215 TIGRFAM TIGR03725 T6A_YeaZ: tRNA threonylcarbamoyl adenosine modification protein YeaZ 1 199 3.8E-55 T 09-03-2017 IPR022496 tRNA threonylcarbamoyl adenosine modification protein YeaZ GO:0002949 TK78_RS08140 a75bca5e1ab3172654a454056ce61e2e 358 ProSitePatterns PS00761 Signal peptidases I signature 3. 210 223 - T 09-03-2017 IPR019758 Peptidase S26A, signal peptidase I, conserved site GO:0008236|GO:0016021 TK78_RS08140 a75bca5e1ab3172654a454056ce61e2e 358 SUPERFAMILY SSF51306 70 118 2.09E-49 T 09-03-2017 IPR015927 Peptidase S24/S26A/S26B/S26C TK78_RS08140 a75bca5e1ab3172654a454056ce61e2e 358 SUPERFAMILY SSF51306 152 257 2.09E-49 T 09-03-2017 IPR015927 Peptidase S24/S26A/S26B/S26C TK78_RS08140 a75bca5e1ab3172654a454056ce61e2e 358 TIGRFAM TIGR02227 sigpep_I_bact: signal peptidase I 57 251 3.0E-40 T 09-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 TK78_RS08140 a75bca5e1ab3172654a454056ce61e2e 358 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 71 87 3.8E-20 T 09-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 TK78_RS08140 a75bca5e1ab3172654a454056ce61e2e 358 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 205 224 3.8E-20 T 09-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 TK78_RS08140 a75bca5e1ab3172654a454056ce61e2e 358 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 157 169 3.8E-20 T 09-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 TK78_RS08140 a75bca5e1ab3172654a454056ce61e2e 358 Pfam PF00717 Peptidase S24-like 78 120 1.6E-12 T 09-03-2017 IPR019759 Peptidase S24/S26A/S26B TK78_RS08140 a75bca5e1ab3172654a454056ce61e2e 358 Pfam PF10502 Signal peptidase, peptidase S26 153 246 1.3E-10 T 09-03-2017 IPR019533 Peptidase S26 TK78_RS08140 a75bca5e1ab3172654a454056ce61e2e 358 Gene3D G3DSA:2.10.109.10 205 260 2.5E-40 T 09-03-2017 IPR028360 Peptidase S24/S26, beta-ribbon domain TK78_RS08140 a75bca5e1ab3172654a454056ce61e2e 358 Gene3D G3DSA:2.10.109.10 151 167 2.5E-40 T 09-03-2017 IPR028360 Peptidase S24/S26, beta-ribbon domain TK78_RS08140 a75bca5e1ab3172654a454056ce61e2e 358 Gene3D G3DSA:2.10.109.10 68 117 2.5E-40 T 09-03-2017 IPR028360 Peptidase S24/S26, beta-ribbon domain TK78_RS23235 2684b46d25047e6923fdcb05525ddfa2 195 Gene3D G3DSA:1.10.10.10 123 185 5.2E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS23235 2684b46d25047e6923fdcb05525ddfa2 195 SUPERFAMILY SSF88659 122 184 1.51E-13 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS23235 2684b46d25047e6923fdcb05525ddfa2 195 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 20 182 3.9E-23 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS23235 2684b46d25047e6923fdcb05525ddfa2 195 Gene3D G3DSA:1.10.1740.10 4 112 3.7E-20 T 09-03-2017 TK78_RS23235 2684b46d25047e6923fdcb05525ddfa2 195 Pfam PF08281 Sigma-70, region 4 127 179 8.7E-13 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS23235 2684b46d25047e6923fdcb05525ddfa2 195 Pfam PF04542 Sigma-70 region 2 23 92 6.2E-12 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS23235 2684b46d25047e6923fdcb05525ddfa2 195 SUPERFAMILY SSF88946 12 107 3.61E-17 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS07260 9d17744793ddbdfb072845af241f4bdd 276 Gene3D G3DSA:2.40.10.10 36 74 1.6E-12 T 09-03-2017 TK78_RS07260 9d17744793ddbdfb072845af241f4bdd 276 SUPERFAMILY SSF50494 20 271 3.95E-62 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS07260 9d17744793ddbdfb072845af241f4bdd 276 SMART SM00020 35 272 1.5E-64 T 09-03-2017 IPR001254 Serine proteases, trypsin domain GO:0004252|GO:0006508 TK78_RS07260 9d17744793ddbdfb072845af241f4bdd 276 Gene3D G3DSA:2.40.10.10 75 138 1.9E-13 T 09-03-2017 TK78_RS07260 9d17744793ddbdfb072845af241f4bdd 276 Gene3D G3DSA:2.40.10.10 139 272 9.7E-40 T 09-03-2017 TK78_RS07260 9d17744793ddbdfb072845af241f4bdd 276 ProSitePatterns PS00135 Serine proteases, trypsin family, serine active site. 227 238 - T 09-03-2017 IPR033116 Serine proteases, trypsin family, serine active site TK78_RS07260 9d17744793ddbdfb072845af241f4bdd 276 Pfam PF00089 Trypsin 36 271 1.4E-52 T 09-03-2017 IPR001254 Serine proteases, trypsin domain GO:0004252|GO:0006508 TK78_RS07260 9d17744793ddbdfb072845af241f4bdd 276 PRINTS PR00722 Chymotrypsin serine protease family (S1) signature 132 146 2.3E-11 T 09-03-2017 IPR001314 Peptidase S1A, chymotrypsin family GO:0004252|GO:0006508 TK78_RS07260 9d17744793ddbdfb072845af241f4bdd 276 PRINTS PR00722 Chymotrypsin serine protease family (S1) signature 69 84 2.3E-11 T 09-03-2017 IPR001314 Peptidase S1A, chymotrypsin family GO:0004252|GO:0006508 TK78_RS07260 9d17744793ddbdfb072845af241f4bdd 276 PRINTS PR00722 Chymotrypsin serine protease family (S1) signature 226 238 2.3E-11 T 09-03-2017 IPR001314 Peptidase S1A, chymotrypsin family GO:0004252|GO:0006508 TK78_RS07260 9d17744793ddbdfb072845af241f4bdd 276 ProSitePatterns PS00134 Serine proteases, trypsin family, histidine active site. 79 84 - T 09-03-2017 IPR018114 Serine proteases, trypsin family, histidine active site GO:0004252|GO:0006508 TK78_RS06645 2d8d7cf0cfe0e9cb458f813b58ea39c1 268 ProSitePatterns PS00211 ABC transporters family signature. 148 162 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS06645 2d8d7cf0cfe0e9cb458f813b58ea39c1 268 Pfam PF00005 ABC transporter 25 175 7.7E-28 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS06645 2d8d7cf0cfe0e9cb458f813b58ea39c1 268 Gene3D G3DSA:3.40.50.300 3 254 5.6E-72 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06645 2d8d7cf0cfe0e9cb458f813b58ea39c1 268 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 227 254 8.0E-7 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS06645 2d8d7cf0cfe0e9cb458f813b58ea39c1 268 SUPERFAMILY SSF52540 10 246 4.22E-62 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06645 2d8d7cf0cfe0e9cb458f813b58ea39c1 268 SMART SM00382 33 225 3.6E-14 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS05590 7b47cb3dab2bed5ea7273d70d723b086 432 Gene3D G3DSA:3.40.190.10 167 352 4.0E-23 T 09-03-2017 TK78_RS05590 7b47cb3dab2bed5ea7273d70d723b086 432 SUPERFAMILY SSF53850 45 421 1.12E-62 T 09-03-2017 TK78_RS05590 7b47cb3dab2bed5ea7273d70d723b086 432 Gene3D G3DSA:3.40.190.10 44 166 9.6E-16 T 09-03-2017 TK78_RS05590 7b47cb3dab2bed5ea7273d70d723b086 432 Pfam PF01547 Bacterial extracellular solute-binding protein 54 339 6.8E-39 T 09-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 TK78_RS28155 4cb0503dbcb5b3c0e09bafdd28d75c77 352 Gene3D G3DSA:3.90.1150.10 265 351 7.7E-6 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS28155 4cb0503dbcb5b3c0e09bafdd28d75c77 352 Gene3D G3DSA:3.40.640.10 32 264 1.3E-34 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS28155 4cb0503dbcb5b3c0e09bafdd28d75c77 352 SUPERFAMILY SSF53383 14 351 7.06E-53 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS28155 4cb0503dbcb5b3c0e09bafdd28d75c77 352 Pfam PF00266 Aminotransferase class-V 50 347 1.2E-17 T 09-03-2017 IPR000192 Aminotransferase class V domain TK78_RS14170 3447a858f7e3d30bf5b6ac20d84a49df 372 Pfam PF01381 Helix-turn-helix 30 63 3.0E-5 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS14170 3447a858f7e3d30bf5b6ac20d84a49df 372 SUPERFAMILY SSF47413 27 65 1.47E-7 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS14170 3447a858f7e3d30bf5b6ac20d84a49df 372 SMART SM00530 28 89 0.0015 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS14170 3447a858f7e3d30bf5b6ac20d84a49df 372 Gene3D G3DSA:1.10.260.40 30 64 1.4E-8 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS30535 c531dd4eb5a0608c1108eed80302e47a 424 ProSitePatterns PS01095 Chitinases family 18 active site. 194 202 - T 09-03-2017 IPR001579 Glycoside hydrolase, chitinase active site GO:0004553|GO:0005975 KEGG: 00520+3.2.1.14|MetaCyc: PWY-6902 TK78_RS30535 c531dd4eb5a0608c1108eed80302e47a 424 Gene3D G3DSA:3.10.50.10 327 385 8.5E-25 T 09-03-2017 IPR029070 Chitinase insertion domain TK78_RS30535 c531dd4eb5a0608c1108eed80302e47a 424 Gene3D G3DSA:3.20.20.80 390 423 6.9E-87 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS30535 c531dd4eb5a0608c1108eed80302e47a 424 Gene3D G3DSA:3.20.20.80 50 326 6.9E-87 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS30535 c531dd4eb5a0608c1108eed80302e47a 424 Pfam PF00704 Glycosyl hydrolases family 18 61 413 2.2E-73 T 09-03-2017 IPR001223 Glycoside hydrolase family 18, catalytic domain GO:0004553|GO:0005975 TK78_RS30535 c531dd4eb5a0608c1108eed80302e47a 424 SUPERFAMILY SSF54556 325 384 3.38E-14 T 09-03-2017 IPR029070 Chitinase insertion domain TK78_RS30535 c531dd4eb5a0608c1108eed80302e47a 424 SUPERFAMILY SSF51445 383 420 1.02E-82 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS30535 c531dd4eb5a0608c1108eed80302e47a 424 SUPERFAMILY SSF51445 54 323 1.02E-82 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS30535 c531dd4eb5a0608c1108eed80302e47a 424 SMART SM00636 60 413 6.4E-117 T 09-03-2017 IPR011583 Chitinase II GO:0004568|GO:0006032 TK78_RS30205 8b6934ae548d695da48cd17e356d4f6c 455 Gene3D G3DSA:3.40.50.300 11 169 7.1E-30 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS30205 8b6934ae548d695da48cd17e356d4f6c 455 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 64 168 8.1E-15 T 09-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 TK78_RS30205 8b6934ae548d695da48cd17e356d4f6c 455 SUPERFAMILY SSF48019 261 443 5.95E-72 T 09-03-2017 IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal GO:0003677|GO:0006260 Reactome: R-HSA-110312|Reactome: R-HSA-110314|Reactome: R-HSA-110320|Reactome: R-HSA-174411|Reactome: R-HSA-5651801|Reactome: R-HSA-5655862|Reactome: R-HSA-5656121|Reactome: R-HSA-5656169|Reactome: R-HSA-5685942|Reactome: R-HSA-5696397|Reactome: R-HSA-5696400|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210|Reactome: R-HSA-69091 TK78_RS30205 8b6934ae548d695da48cd17e356d4f6c 455 Gene3D G3DSA:1.10.3710.10 357 445 9.9E-27 T 09-03-2017 TK78_RS30205 8b6934ae548d695da48cd17e356d4f6c 455 Gene3D G3DSA:1.10.8.60 177 250 9.9E-10 T 09-03-2017 TK78_RS30205 8b6934ae548d695da48cd17e356d4f6c 455 SMART SM00382 60 181 6.2E-12 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS30205 8b6934ae548d695da48cd17e356d4f6c 455 Pfam PF12002 MgsA AAA+ ATPase C terminal 276 441 1.4E-67 T 09-03-2017 IPR021886 MgsA AAA+ ATPase C-terminal TK78_RS30205 8b6934ae548d695da48cd17e356d4f6c 455 SUPERFAMILY SSF52540 19 244 1.64E-41 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS30205 8b6934ae548d695da48cd17e356d4f6c 455 Gene3D G3DSA:1.20.272.10 257 355 6.3E-45 T 09-03-2017 TK78_RS30205 8b6934ae548d695da48cd17e356d4f6c 455 Pfam PF16193 AAA C-terminal domain 199 275 7.7E-26 T 09-03-2017 IPR032423 AAA ATPase, C-terminal domain TK78_RS13795 7abb41dcb3baa6e08329db7b43a42cac 151 Pfam PF12172 Rubredoxin-like zinc ribbon domain (DUF35_N) 20 56 1.7E-8 T 09-03-2017 IPR022002 Domain of unknown function DUF35, rubredoxin-like zinc ribbon domain, N-terminal TK78_RS13795 7abb41dcb3baa6e08329db7b43a42cac 151 SUPERFAMILY SSF50249 8 139 2.23E-29 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS13795 7abb41dcb3baa6e08329db7b43a42cac 151 Pfam PF01796 DUF35 OB-fold domain, acyl-CoA-associated 59 133 1.0E-16 T 09-03-2017 IPR002878 Domain of unknown function DUF35, OB-fold, C-terminal TK78_RS33305 7d4cab983ec36b796ca66b4afc2adeb1 344 TIGRFAM TIGR00747 fabH: 3-oxoacyl-[acyl-carrier-protein] synthase III 2 323 4.0E-89 T 09-03-2017 IPR004655 3-oxoacyl-[acyl-carrier-protein] synthase 3 GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 TK78_RS33305 7d4cab983ec36b796ca66b4afc2adeb1 344 Pfam PF08545 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III 102 182 9.3E-25 T 09-03-2017 IPR013751 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 TK78_RS33305 7d4cab983ec36b796ca66b4afc2adeb1 344 Gene3D G3DSA:3.40.47.10 155 325 4.8E-47 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS33305 7d4cab983ec36b796ca66b4afc2adeb1 344 Gene3D G3DSA:3.40.47.10 2 154 2.9E-43 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS33305 7d4cab983ec36b796ca66b4afc2adeb1 344 Pfam PF08541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal 234 323 1.4E-34 T 09-03-2017 IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, C-terminal KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 TK78_RS33305 7d4cab983ec36b796ca66b4afc2adeb1 344 SUPERFAMILY SSF53901 9 324 1.74E-51 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS16785 9134aedee4a150729332396c85fc9933 332 SUPERFAMILY SSF54637 51 182 3.06E-15 T 09-03-2017 IPR029069 HotDog domain TK78_RS16785 9134aedee4a150729332396c85fc9933 332 SUPERFAMILY SSF50249 192 321 3.94E-32 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS16785 9134aedee4a150729332396c85fc9933 332 Pfam PF12172 Rubredoxin-like zinc ribbon domain (DUF35_N) 210 246 2.9E-8 T 09-03-2017 IPR022002 Domain of unknown function DUF35, rubredoxin-like zinc ribbon domain, N-terminal TK78_RS16785 9134aedee4a150729332396c85fc9933 332 Gene3D G3DSA:3.10.129.10 47 181 3.6E-11 T 09-03-2017 IPR029069 HotDog domain TK78_RS16785 9134aedee4a150729332396c85fc9933 332 Pfam PF01796 DUF35 OB-fold domain, acyl-CoA-associated 248 314 3.2E-18 T 09-03-2017 IPR002878 Domain of unknown function DUF35, OB-fold, C-terminal TK78_RS16785 9134aedee4a150729332396c85fc9933 332 Pfam PF13452 N-terminal half of MaoC dehydratase 46 173 1.1E-14 T 09-03-2017 TK78_RS20220 cbac9916b9d066093ceb157c411cf42c 248 SUPERFAMILY SSF53254 25 215 8.54E-36 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS20220 cbac9916b9d066093ceb157c411cf42c 248 Gene3D G3DSA:3.40.50.1240 26 212 1.4E-30 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS20220 cbac9916b9d066093ceb157c411cf42c 248 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 27 213 1.6E-35 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS20220 cbac9916b9d066093ceb157c411cf42c 248 SMART SM00855 25 177 2.0E-16 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS27750 c695eccc1232bf8b9cfbbb912e714302 215 SUPERFAMILY SSF52540 46 174 2.51E-5 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27750 c695eccc1232bf8b9cfbbb912e714302 215 Gene3D G3DSA:3.40.50.300 26 200 1.3E-15 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17705 67786b5d061449f9265eada896b3d293 343 SUPERFAMILY SSF56112 2 332 6.12E-39 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS17705 67786b5d061449f9265eada896b3d293 343 Gene3D G3DSA:3.30.200.20 2 98 1.3E-10 T 09-03-2017 TK78_RS17705 67786b5d061449f9265eada896b3d293 343 Pfam PF01636 Phosphotransferase enzyme family 15 280 1.4E-25 T 09-03-2017 IPR002575 Aminoglycoside phosphotransferase TK78_RS17705 67786b5d061449f9265eada896b3d293 343 Gene3D G3DSA:3.90.1200.10 109 338 3.1E-19 T 09-03-2017 TK78_RS19320 b7c37307c2131b0697dd0da89639df41 304 SUPERFAMILY SSF47240 90 247 6.76E-6 T 09-03-2017 IPR009078 Ferritin-like superfamily TK78_RS19320 b7c37307c2131b0697dd0da89639df41 304 Pfam PF11583 P-aminobenzoate N-oxygenase AurF 16 286 7.6E-95 T 09-03-2017 IPR025859 P-aminobenzoate N-oxygenase AurF TK78_RS23415 c6539a96ba1ec355a21adb59ab10a2bb 213 SUPERFAMILY SSF55729 11 169 5.12E-22 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS23415 c6539a96ba1ec355a21adb59ab10a2bb 213 Pfam PF13302 Acetyltransferase (GNAT) domain 17 164 1.5E-15 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS23415 c6539a96ba1ec355a21adb59ab10a2bb 213 Gene3D G3DSA:3.40.630.30 11 169 2.1E-24 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS04915 30378f00b10b9e47df170dcd42aa1a78 205 Gene3D G3DSA:3.90.550.10 11 204 1.2E-32 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS04915 30378f00b10b9e47df170dcd42aa1a78 205 Pfam PF12804 MobA-like NTP transferase domain 16 178 2.4E-36 T 09-03-2017 IPR025877 MobA-like NTP transferase TK78_RS04915 30378f00b10b9e47df170dcd42aa1a78 205 SUPERFAMILY SSF53448 13 201 7.3E-32 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS30540 def24401cf53e0e0dd30a6c5b221cc74 390 Gene3D G3DSA:1.10.540.10 15 125 3.7E-28 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS30540 def24401cf53e0e0dd30a6c5b221cc74 390 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 236 384 1.5E-52 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS30540 def24401cf53e0e0dd30a6c5b221cc74 390 SUPERFAMILY SSF56645 13 249 3.66E-72 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS30540 def24401cf53e0e0dd30a6c5b221cc74 390 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 15 125 2.9E-22 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS30540 def24401cf53e0e0dd30a6c5b221cc74 390 PIRSF PIRSF016578 5 390 3.6E-15 T 09-03-2017 TK78_RS30540 def24401cf53e0e0dd30a6c5b221cc74 390 Gene3D G3DSA:2.40.110.10 129 223 1.5E-38 T 09-03-2017 TK78_RS30540 def24401cf53e0e0dd30a6c5b221cc74 390 ProSitePatterns PS00072 Acyl-CoA dehydrogenases signature 1. 132 144 - T 09-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 TK78_RS30540 def24401cf53e0e0dd30a6c5b221cc74 390 SUPERFAMILY SSF47203 234 386 4.83E-61 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS30540 def24401cf53e0e0dd30a6c5b221cc74 390 ProSitePatterns PS00073 Acyl-CoA dehydrogenases signature 2. 343 362 - T 09-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 TK78_RS30540 def24401cf53e0e0dd30a6c5b221cc74 390 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 130 224 5.0E-26 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS30540 def24401cf53e0e0dd30a6c5b221cc74 390 Gene3D G3DSA:1.20.140.10 224 386 9.6E-72 T 09-03-2017 TK78_RS21390 c2dc7dfb87c4b5b3a44c6bf4ca30b9ce 325 Pfam PF09346 SMI1 / KNR4 family (SUKH-1) 161 273 6.7E-7 T 09-03-2017 IPR018958 SMI1/KNR4-like domain TK78_RS21390 c2dc7dfb87c4b5b3a44c6bf4ca30b9ce 325 SMART SM00860 160 297 5.3E-5 T 09-03-2017 IPR018958 SMI1/KNR4-like domain TK78_RS21390 c2dc7dfb87c4b5b3a44c6bf4ca30b9ce 325 Gene3D G3DSA:3.40.1580.10 159 190 9.0E-6 T 09-03-2017 IPR018958 SMI1/KNR4-like domain TK78_RS21390 c2dc7dfb87c4b5b3a44c6bf4ca30b9ce 325 Pfam PF14414 A nuclease of the HNH/ENDO VII superfamily with conserved WHH 96 129 1.4E-10 T 09-03-2017 IPR032869 WHH domain-containing protein TK78_RS21390 c2dc7dfb87c4b5b3a44c6bf4ca30b9ce 325 SUPERFAMILY SSF160631 150 298 4.05E-15 T 09-03-2017 TK78_RS15385 07057928b49562dc42f3780faf014b9c 666 Pfam PF13193 AMP-binding enzyme C-terminal domain 546 624 1.8E-26 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS15385 07057928b49562dc42f3780faf014b9c 666 Pfam PF00501 AMP-binding enzyme 104 537 5.1E-91 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS15385 07057928b49562dc42f3780faf014b9c 666 Gene3D G3DSA:3.30.300.30 534 647 9.8E-29 T 09-03-2017 TK78_RS15385 07057928b49562dc42f3780faf014b9c 666 Gene3D G3DSA:3.40.50.980 95 280 1.4E-42 T 09-03-2017 TK78_RS15385 07057928b49562dc42f3780faf014b9c 666 Pfam PF16177 Acetyl-coenzyme A synthetase N-terminus 45 97 1.3E-20 T 09-03-2017 IPR032387 Acetyl-coenzyme A synthetase, N-terminal domain KEGG: 00010+6.2.1.1|KEGG: 00620+6.2.1.1|KEGG: 00640+6.2.1.1|KEGG: 00680+6.2.1.1|KEGG: 00720+6.2.1.1|MetaCyc: PWY-6672|MetaCyc: PWY-7118 TK78_RS15385 07057928b49562dc42f3780faf014b9c 666 SUPERFAMILY SSF56801 46 656 4.71E-177 T 09-03-2017 TK78_RS15385 07057928b49562dc42f3780faf014b9c 666 TIGRFAM TIGR02188 Ac_CoA_lig_AcsA: acetate--CoA ligase 39 655 5.0E-299 T 09-03-2017 IPR011904 Acetate-CoA ligase GO:0003987|GO:0016208|GO:0019427 KEGG: 00010+6.2.1.1|KEGG: 00620+6.2.1.1|KEGG: 00640+6.2.1.1|KEGG: 00680+6.2.1.1|KEGG: 00720+6.2.1.1|MetaCyc: PWY-6672|MetaCyc: PWY-7118|Reactome: R-HSA-71384 TK78_RS15385 07057928b49562dc42f3780faf014b9c 666 Gene3D G3DSA:3.40.50.980 281 439 1.9E-28 T 09-03-2017 TK78_RS15385 07057928b49562dc42f3780faf014b9c 666 Gene3D G3DSA:2.30.38.10 454 530 2.6E-6 T 09-03-2017 TK78_RS15385 07057928b49562dc42f3780faf014b9c 666 ProSitePatterns PS00455 Putative AMP-binding domain signature. 275 286 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS15385 07057928b49562dc42f3780faf014b9c 666 Hamap MF_01123 Acetyl-coenzyme A synthetase [acs]. 25 658 51.353 T 09-03-2017 IPR011904 Acetate-CoA ligase GO:0003987|GO:0016208|GO:0019427 KEGG: 00010+6.2.1.1|KEGG: 00620+6.2.1.1|KEGG: 00640+6.2.1.1|KEGG: 00680+6.2.1.1|KEGG: 00720+6.2.1.1|MetaCyc: PWY-6672|MetaCyc: PWY-7118|Reactome: R-HSA-71384 TK78_RS14870 5fe150133b3e478cc85277b58db66fe6 434 Gene3D G3DSA:3.40.190.10 174 362 4.0E-29 T 09-03-2017 TK78_RS14870 5fe150133b3e478cc85277b58db66fe6 434 Gene3D G3DSA:3.40.190.10 60 173 3.8E-13 T 09-03-2017 TK78_RS14870 5fe150133b3e478cc85277b58db66fe6 434 SUPERFAMILY SSF53850 41 431 2.52E-56 T 09-03-2017 TK78_RS14870 5fe150133b3e478cc85277b58db66fe6 434 Pfam PF13416 Bacterial extracellular solute-binding protein 60 365 1.2E-34 T 09-03-2017 TK78_RS16450 38bdecf224eb2df4c4de2ee83f942e20 573 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 21 138 6.9E-7 T 09-03-2017 IPR000014 PAS domain TK78_RS16450 38bdecf224eb2df4c4de2ee83f942e20 573 Pfam PF08448 PAS fold 24 132 4.0E-16 T 09-03-2017 IPR013656 PAS fold-4 TK78_RS16450 38bdecf224eb2df4c4de2ee83f942e20 573 SUPERFAMILY SSF55781 230 330 7.63E-11 T 09-03-2017 IPR029016 GAF domain-like TK78_RS16450 38bdecf224eb2df4c4de2ee83f942e20 573 SUPERFAMILY SSF55785 29 140 1.77E-13 T 09-03-2017 IPR000014 PAS domain TK78_RS16450 38bdecf224eb2df4c4de2ee83f942e20 573 SMART SM00065 160 331 0.0074 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS16450 38bdecf224eb2df4c4de2ee83f942e20 573 Gene3D G3DSA:3.30.450.20 20 130 1.2E-16 T 09-03-2017 TK78_RS16450 38bdecf224eb2df4c4de2ee83f942e20 573 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 379 560 1.4E-42 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS16450 38bdecf224eb2df4c4de2ee83f942e20 573 Pfam PF01590 GAF domain 215 319 2.2E-6 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS16450 38bdecf224eb2df4c4de2ee83f942e20 573 SMART SM00331 349 560 7.9E-29 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS16450 38bdecf224eb2df4c4de2ee83f942e20 573 SUPERFAMILY SSF81606 367 557 6.02E-9 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS16450 38bdecf224eb2df4c4de2ee83f942e20 573 Gene3D G3DSA:3.30.450.40 149 328 7.2E-30 T 09-03-2017 IPR029016 GAF domain-like TK78_RS32780 1556b00f091c7938bfc4abbb08336112 151 TIGRFAM TIGR00026 hi_GC_TIGR00026: deazaflavin-dependent oxidoreductase, nitroreductase family 36 116 5.5E-13 T 09-03-2017 IPR004378 Deazaflavin-dependent nitroreductase/F420H(2)-dependent quinone reductase GO:0016491|GO:0055114 TK78_RS32780 1556b00f091c7938bfc4abbb08336112 151 Pfam PF04075 Domain of unknown function (DUF385) 28 115 3.7E-9 T 09-03-2017 IPR004378 Deazaflavin-dependent nitroreductase/F420H(2)-dependent quinone reductase GO:0016491|GO:0055114 TK78_RS32780 1556b00f091c7938bfc4abbb08336112 151 Gene3D G3DSA:2.30.110.10 37 150 2.2E-5 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS01755 b39305ab0a5e5b06e5d081d30edb77a1 384 Pfam PF07683 Cobalamin synthesis protein cobW C-terminal domain 241 356 5.4E-20 T 09-03-2017 IPR011629 Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal TK78_RS01755 b39305ab0a5e5b06e5d081d30edb77a1 384 Gene3D G3DSA:3.40.50.300 68 206 9.5E-8 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01755 b39305ab0a5e5b06e5d081d30edb77a1 384 Gene3D G3DSA:3.30.1220.10 233 356 1.6E-8 T 09-03-2017 IPR011629 Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal TK78_RS01755 b39305ab0a5e5b06e5d081d30edb77a1 384 SUPERFAMILY SSF90002 241 303 4.18E-11 T 09-03-2017 IPR011629 Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal TK78_RS01755 b39305ab0a5e5b06e5d081d30edb77a1 384 SUPERFAMILY SSF90002 330 356 4.18E-11 T 09-03-2017 IPR011629 Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal TK78_RS01755 b39305ab0a5e5b06e5d081d30edb77a1 384 SMART SM00833 240 356 2.4E-40 T 09-03-2017 IPR011629 Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal TK78_RS13800 95c2f4e7ea54d4637cbde64fc81d3aa9 258 SUPERFAMILY SSF52096 8 242 4.98E-45 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS13800 95c2f4e7ea54d4637cbde64fc81d3aa9 258 Pfam PF00378 Enoyl-CoA hydratase/isomerase 9 223 3.1E-28 T 09-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 TK78_RS13800 95c2f4e7ea54d4637cbde64fc81d3aa9 258 Gene3D G3DSA:3.90.226.10 5 226 3.3E-45 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS16330 4bc6ed8cea1898b4b913a75b84d62c27 271 ProSitePatterns PS00166 Enoyl-CoA hydratase/isomerase signature. 115 135 - T 09-03-2017 IPR018376 Enoyl-CoA hydratase/isomerase, conserved site GO:0003824|GO:0008152 TK78_RS16330 4bc6ed8cea1898b4b913a75b84d62c27 271 Gene3D G3DSA:3.90.226.10 10 234 2.4E-53 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS16330 4bc6ed8cea1898b4b913a75b84d62c27 271 Pfam PF00378 Enoyl-CoA hydratase/isomerase 22 251 1.0E-36 T 09-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 TK78_RS16330 4bc6ed8cea1898b4b913a75b84d62c27 271 SUPERFAMILY SSF52096 14 248 7.47E-52 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS20335 30f87d60bac258b909534df9c2d75977 525 SUPERFAMILY SSF81606 299 504 9.68E-6 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS20335 30f87d60bac258b909534df9c2d75977 525 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 318 505 1.2E-36 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS20335 30f87d60bac258b909534df9c2d75977 525 SUPERFAMILY SSF55781 118 264 2.84E-11 T 09-03-2017 IPR029016 GAF domain-like TK78_RS20335 30f87d60bac258b909534df9c2d75977 525 Gene3D G3DSA:3.30.450.40 106 263 3.8E-16 T 09-03-2017 IPR029016 GAF domain-like TK78_RS20335 30f87d60bac258b909534df9c2d75977 525 SMART SM00331 283 506 1.3E-25 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS07525 796bf219ecd938eca407c9de80c5c7bf 101 Pfam PF05437 Branched-chain amino acid transport protein (AzlD) 3 98 1.2E-12 T 09-03-2017 IPR008407 Branched-chain amino acid transport, AzlD TK78_RS25360 2ad596a1aec7ddf9980cacd8674bc3f4 505 SUPERFAMILY SSF52096 301 504 2.28E-38 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS25360 2ad596a1aec7ddf9980cacd8674bc3f4 505 Gene3D G3DSA:3.90.226.10 339 499 1.3E-24 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS25360 2ad596a1aec7ddf9980cacd8674bc3f4 505 PRINTS PR01070 Acetyl-CoA carboxylase carboxyl transferase beta subunit signature 152 169 1.4E-13 T 09-03-2017 IPR000438 Acetyl-CoA carboxylase carboxyl transferase, beta subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388 TK78_RS25360 2ad596a1aec7ddf9980cacd8674bc3f4 505 PRINTS PR01070 Acetyl-CoA carboxylase carboxyl transferase beta subunit signature 115 133 1.4E-13 T 09-03-2017 IPR000438 Acetyl-CoA carboxylase carboxyl transferase, beta subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388 TK78_RS25360 2ad596a1aec7ddf9980cacd8674bc3f4 505 PRINTS PR01070 Acetyl-CoA carboxylase carboxyl transferase beta subunit signature 181 192 1.4E-13 T 09-03-2017 IPR000438 Acetyl-CoA carboxylase carboxyl transferase, beta subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388 TK78_RS25360 2ad596a1aec7ddf9980cacd8674bc3f4 505 PRINTS PR01070 Acetyl-CoA carboxylase carboxyl transferase beta subunit signature 81 95 1.4E-13 T 09-03-2017 IPR000438 Acetyl-CoA carboxylase carboxyl transferase, beta subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388 TK78_RS25360 2ad596a1aec7ddf9980cacd8674bc3f4 505 Pfam PF01039 Carboxyl transferase domain 349 475 1.2E-9 T 09-03-2017 IPR000022 Carboxyl transferase KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TK78_RS25360 2ad596a1aec7ddf9980cacd8674bc3f4 505 Pfam PF01039 Carboxyl transferase domain 52 206 3.5E-17 T 09-03-2017 IPR000022 Carboxyl transferase KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TK78_RS25360 2ad596a1aec7ddf9980cacd8674bc3f4 505 Gene3D G3DSA:3.90.226.10 3 227 7.9E-36 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS25360 2ad596a1aec7ddf9980cacd8674bc3f4 505 SUPERFAMILY SSF52096 6 231 1.1E-45 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS04525 e88fab34bda2192df04d4ef7a5b09a1c 261 PIRSF PIRSF000090 3 261 1.6E-84 T 09-03-2017 IPR012255 Electron transfer flavoprotein, beta subunit GO:0009055 Reactome: R-HSA-611105 TK78_RS04525 e88fab34bda2192df04d4ef7a5b09a1c 261 Pfam PF01012 Electron transfer flavoprotein domain 25 209 1.4E-45 T 09-03-2017 IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal Reactome: R-HSA-611105 TK78_RS04525 e88fab34bda2192df04d4ef7a5b09a1c 261 SUPERFAMILY SSF52402 3 257 4.19E-72 T 09-03-2017 TK78_RS04525 e88fab34bda2192df04d4ef7a5b09a1c 261 SMART SM00893 24 214 4.8E-58 T 09-03-2017 IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal Reactome: R-HSA-611105 TK78_RS04525 e88fab34bda2192df04d4ef7a5b09a1c 261 Gene3D G3DSA:3.40.50.620 3 260 1.1E-85 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS10880 962c557215b55593d60bdfdda036b0be 945 Pfam PF00069 Protein kinase domain 245 437 7.2E-12 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS10880 962c557215b55593d60bdfdda036b0be 945 Pfam PF05147 Lanthionine synthetase C-like protein 680 799 1.7E-5 T 09-03-2017 IPR007822 Lanthionine synthetase C-like TK78_RS10880 962c557215b55593d60bdfdda036b0be 945 Gene3D G3DSA:3.30.200.20 234 367 5.6E-12 T 09-03-2017 TK78_RS10880 962c557215b55593d60bdfdda036b0be 945 SMART SM00220 234 477 1.5E-6 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS10880 962c557215b55593d60bdfdda036b0be 945 Gene3D G3DSA:1.10.510.10 368 437 3.0E-8 T 09-03-2017 TK78_RS10880 962c557215b55593d60bdfdda036b0be 945 SMART SM01260 595 919 1.1E-5 T 09-03-2017 IPR007822 Lanthionine synthetase C-like TK78_RS10880 962c557215b55593d60bdfdda036b0be 945 SUPERFAMILY SSF56112 234 441 6.74E-23 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS10880 962c557215b55593d60bdfdda036b0be 945 SUPERFAMILY SSF158745 590 905 1.7E-19 T 09-03-2017 TK78_RS22960 d9038c65cc3b2e8ce0c5037b82050818 256 SUPERFAMILY SSF64288 77 251 1.73E-45 T 09-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain TK78_RS22960 d9038c65cc3b2e8ce0c5037b82050818 256 Gene3D G3DSA:3.40.1410.10 86 250 1.6E-45 T 09-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain TK78_RS22960 d9038c65cc3b2e8ce0c5037b82050818 256 SUPERFAMILY SSF46785 21 92 1.4E-13 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS22960 d9038c65cc3b2e8ce0c5037b82050818 256 Gene3D G3DSA:1.10.10.10 20 85 5.5E-16 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS22960 d9038c65cc3b2e8ce0c5037b82050818 256 Pfam PF07702 UTRA domain 106 244 7.3E-33 T 09-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 TK78_RS22960 d9038c65cc3b2e8ce0c5037b82050818 256 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 46 60 1.5E-8 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS22960 d9038c65cc3b2e8ce0c5037b82050818 256 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 60 76 1.5E-8 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS22960 d9038c65cc3b2e8ce0c5037b82050818 256 SMART SM00866 105 245 3.6E-32 T 09-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 TK78_RS22960 d9038c65cc3b2e8ce0c5037b82050818 256 Pfam PF00392 Bacterial regulatory proteins, gntR family 36 85 1.1E-10 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS22960 d9038c65cc3b2e8ce0c5037b82050818 256 SMART SM00345 29 85 9.2E-7 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS08950 636cd2c930974249278e561ecd2cccd7 334 SUPERFAMILY SSF161098 88 159 1.8E-15 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS08950 636cd2c930974249278e561ecd2cccd7 334 SUPERFAMILY SSF161098 196 318 1.8E-15 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS08950 636cd2c930974249278e561ecd2cccd7 334 Gene3D G3DSA:1.10.3720.10 87 162 1.9E-16 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS08950 636cd2c930974249278e561ecd2cccd7 334 Gene3D G3DSA:1.10.3720.10 199 325 1.9E-16 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS08950 636cd2c930974249278e561ecd2cccd7 334 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 113 332 8.2E-36 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS25485 cf1b928aefda50ecf95c7f4432b89102 471 Gene3D G3DSA:1.20.1250.20 286 469 3.8E-10 T 09-03-2017 TK78_RS25485 cf1b928aefda50ecf95c7f4432b89102 471 Gene3D G3DSA:1.20.1250.20 31 207 5.7E-30 T 09-03-2017 TK78_RS25485 cf1b928aefda50ecf95c7f4432b89102 471 Pfam PF07690 Major Facilitator Superfamily 35 424 4.3E-40 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS25485 cf1b928aefda50ecf95c7f4432b89102 471 SUPERFAMILY SSF103473 264 470 3.92E-42 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS25485 cf1b928aefda50ecf95c7f4432b89102 471 SUPERFAMILY SSF103473 31 217 3.92E-42 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS03310 42eb68bad2053ed491173a019198c3bd 243 SUPERFAMILY SSF46955 10 83 1.43E-17 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS03310 42eb68bad2053ed491173a019198c3bd 243 Pfam PF13411 MerR HTH family regulatory protein 11 78 3.5E-19 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS03310 42eb68bad2053ed491173a019198c3bd 243 Gene3D G3DSA:1.10.1660.10 11 80 9.8E-19 T 09-03-2017 TK78_RS03310 42eb68bad2053ed491173a019198c3bd 243 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 46 66 1.1E-9 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS03310 42eb68bad2053ed491173a019198c3bd 243 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 22 35 1.1E-9 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS03310 42eb68bad2053ed491173a019198c3bd 243 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 11 22 1.1E-9 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS03310 42eb68bad2053ed491173a019198c3bd 243 SMART SM00422 10 79 4.5E-20 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS30115 838c702e294b7717101fae56190eb23b 208 SMART SM00278 107 126 0.33 T 09-03-2017 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 TK78_RS30115 838c702e294b7717101fae56190eb23b 208 SMART SM00278 72 91 45.0 T 09-03-2017 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 TK78_RS30115 838c702e294b7717101fae56190eb23b 208 Gene3D G3DSA:2.40.50.140 1 63 1.1E-21 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS30115 838c702e294b7717101fae56190eb23b 208 Pfam PF07499 RuvA, C-terminal domain 152 204 1.5E-10 T 09-03-2017 IPR011114 DNA helicase, Holliday junction RuvA type, domain III, C-terminal GO:0005524|GO:0006281|GO:0006310|GO:0009378|GO:0009379 TK78_RS30115 838c702e294b7717101fae56190eb23b 208 SUPERFAMILY SSF50249 1 62 8.0E-14 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS30115 838c702e294b7717101fae56190eb23b 208 Gene3D G3DSA:1.10.8.10 150 208 6.4E-12 T 09-03-2017 TK78_RS30115 838c702e294b7717101fae56190eb23b 208 Pfam PF01330 RuvA N terminal domain 1 61 2.1E-18 T 09-03-2017 IPR013849 DNA helicase, Holliday junction RuvA type, domain I, bacterial GO:0005524|GO:0006281|GO:0006310|GO:0009378 TK78_RS30115 838c702e294b7717101fae56190eb23b 208 SUPERFAMILY SSF47781 65 132 6.99E-18 T 09-03-2017 IPR010994 RuvA domain 2-like TK78_RS30115 838c702e294b7717101fae56190eb23b 208 Gene3D G3DSA:1.10.150.20 66 133 4.1E-25 T 09-03-2017 TK78_RS30115 838c702e294b7717101fae56190eb23b 208 Hamap MF_00031 Holliday junction ATP-dependent DNA helicase RuvA [ruvA]. 1 205 26.402 T 09-03-2017 IPR000085 Bacterial DNA recombination protein RuvA GO:0003678|GO:0006281|GO:0006310 TK78_RS30115 838c702e294b7717101fae56190eb23b 208 TIGRFAM TIGR00084 ruvA: Holliday junction DNA helicase RuvA 1 187 8.9E-39 T 09-03-2017 IPR000085 Bacterial DNA recombination protein RuvA GO:0003678|GO:0006281|GO:0006310 TK78_RS30115 838c702e294b7717101fae56190eb23b 208 Pfam PF14520 Helix-hairpin-helix domain 71 129 1.5E-14 T 09-03-2017 TK78_RS30115 838c702e294b7717101fae56190eb23b 208 SUPERFAMILY SSF46929 151 206 8.76E-8 T 09-03-2017 IPR011114 DNA helicase, Holliday junction RuvA type, domain III, C-terminal GO:0005524|GO:0006281|GO:0006310|GO:0009378|GO:0009379 TK78_RS28440 7132584af6b852726be0cdb57463bd81 432 TIGRFAM TIGR00896 CynX: cyanate transporter 45 404 2.3E-135 T 09-03-2017 IPR004747 Cyanate transport system protein GO:0016021 TK78_RS28440 7132584af6b852726be0cdb57463bd81 432 Pfam PF07690 Major Facilitator Superfamily 61 356 1.4E-22 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS28440 7132584af6b852726be0cdb57463bd81 432 Gene3D G3DSA:1.20.1250.20 245 422 2.4E-10 T 09-03-2017 TK78_RS28440 7132584af6b852726be0cdb57463bd81 432 Gene3D G3DSA:1.20.1250.20 47 222 1.6E-17 T 09-03-2017 TK78_RS28440 7132584af6b852726be0cdb57463bd81 432 SUPERFAMILY SSF103473 29 424 2.75E-46 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS20530 88880f757e21c687aef5c4f144a552ed 150 Pfam PF13404 AsnC-type helix-turn-helix domain 1 42 1.6E-15 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS20530 88880f757e21c687aef5c4f144a552ed 150 SMART SM00344 1 106 6.0E-31 T 09-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 TK78_RS20530 88880f757e21c687aef5c4f144a552ed 150 SUPERFAMILY SSF46785 1 60 1.7E-14 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS20530 88880f757e21c687aef5c4f144a552ed 150 Gene3D G3DSA:1.10.10.10 2 52 9.7E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS20530 88880f757e21c687aef5c4f144a552ed 150 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 1 17 1.5E-11 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS20530 88880f757e21c687aef5c4f144a552ed 150 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 17 28 1.5E-11 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS20530 88880f757e21c687aef5c4f144a552ed 150 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 28 47 1.5E-11 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS20530 88880f757e21c687aef5c4f144a552ed 150 SUPERFAMILY SSF54909 64 141 2.01E-14 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS20530 88880f757e21c687aef5c4f144a552ed 150 Pfam PF01037 Lrp/AsnC ligand binding domain 74 136 1.1E-15 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS20530 88880f757e21c687aef5c4f144a552ed 150 ProSitePatterns PS00519 AsnC-type HTH domain signature. 19 45 - T 09-03-2017 IPR019885 Transcription regulator HTH, AsnC-type, conserved site TK78_RS20530 88880f757e21c687aef5c4f144a552ed 150 Gene3D G3DSA:3.30.70.920 54 142 8.5E-18 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS21475 d3d5351eb19d9c6d3d69018124026022 181 Gene3D G3DSA:1.10.10.10 125 181 1.4E-9 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS21475 d3d5351eb19d9c6d3d69018124026022 181 SUPERFAMILY SSF46894 122 181 7.14E-7 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS21475 d3d5351eb19d9c6d3d69018124026022 181 Gene3D G3DSA:1.10.10.10 4 91 1.5E-4 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS21475 d3d5351eb19d9c6d3d69018124026022 181 SMART SM00421 118 175 0.0023 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS17190 5cf97d74384c235208da91692b163ffa 239 Gene3D G3DSA:3.40.50.1820 1 231 6.0E-40 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS17190 5cf97d74384c235208da91692b163ffa 239 SUPERFAMILY SSF53474 1 232 2.99E-36 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS17190 5cf97d74384c235208da91692b163ffa 239 Pfam PF01738 Dienelactone hydrolase family 11 233 3.7E-35 T 09-03-2017 IPR002925 Dienelactone hydrolase GO:0016787 TK78_RS29570 80262712f10944941fc322c7bde9199f 237 Pfam PF00230 Major intrinsic protein 4 219 2.4E-50 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS29570 80262712f10944941fc322c7bde9199f 237 TIGRFAM TIGR00861 MIP: MIP family channel proteins 8 218 1.2E-53 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS29570 80262712f10944941fc322c7bde9199f 237 ProSitePatterns PS00221 MIP family signature. 58 66 - T 09-03-2017 IPR022357 Major intrinsic protein, conserved site GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS29570 80262712f10944941fc322c7bde9199f 237 Gene3D G3DSA:1.20.1080.10 4 221 1.3E-61 T 09-03-2017 IPR023271 Aquaporin-like Reactome: R-HSA-432047 TK78_RS29570 80262712f10944941fc322c7bde9199f 237 PRINTS PR00783 Major intrinsic protein family signature 77 96 5.5E-53 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS29570 80262712f10944941fc322c7bde9199f 237 PRINTS PR00783 Major intrinsic protein family signature 4 23 5.5E-53 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS29570 80262712f10944941fc322c7bde9199f 237 PRINTS PR00783 Major intrinsic protein family signature 202 222 5.5E-53 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS29570 80262712f10944941fc322c7bde9199f 237 PRINTS PR00783 Major intrinsic protein family signature 133 151 5.5E-53 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS29570 80262712f10944941fc322c7bde9199f 237 PRINTS PR00783 Major intrinsic protein family signature 40 64 5.5E-53 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS29570 80262712f10944941fc322c7bde9199f 237 PRINTS PR00783 Major intrinsic protein family signature 163 185 5.5E-53 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS29570 80262712f10944941fc322c7bde9199f 237 SUPERFAMILY SSF81338 4 224 2.49E-59 T 09-03-2017 IPR023271 Aquaporin-like Reactome: R-HSA-432047 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 Gene3D G3DSA:3.40.50.360 871 1018 1.8E-44 T 09-03-2017 IPR029039 Flavoprotein-like domain TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 SUPERFAMILY SSF52218 871 1017 1.66E-44 T 09-03-2017 IPR029039 Flavoprotein-like domain TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 SUPERFAMILY SSF52343 1265 1419 1.7E-48 T 09-03-2017 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 SUPERFAMILY SSF53706 13 556 1.44E-189 T 09-03-2017 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 Pfam PF00667 FAD binding domain 1055 1245 8.3E-22 T 09-03-2017 IPR003097 FAD-binding, type 1 GO:0016491|GO:0055114 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 Pfam PF00258 Flavodoxin 876 1007 3.3E-29 T 09-03-2017 IPR008254 Flavodoxin/nitric oxide synthase GO:0010181 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 Gene3D G3DSA:1.20.990.10 1098 1203 1.5E-24 T 09-03-2017 IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain-3 GO:0016491|GO:0055114 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 SUPERFAMILY SSF50692 587 732 7.69E-46 T 09-03-2017 IPR009010 Aspartate decarboxylase-like domain TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 SUPERFAMILY SSF63380 1047 1266 4.76E-54 T 09-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 Pfam PF00175 Oxidoreductase NAD-binding domain 1277 1383 9.9E-18 T 09-03-2017 IPR001433 Oxidoreductase FAD/NAD(P)-binding GO:0016491|GO:0055114 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 PRINTS PR00371 Flavoprotein pyridine nucleotide cytochrome reductase signature 1240 1249 2.7E-25 T 09-03-2017 IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase GO:0016491|GO:0055114 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 PRINTS PR00371 Flavoprotein pyridine nucleotide cytochrome reductase signature 1087 1097 2.7E-25 T 09-03-2017 IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase GO:0016491|GO:0055114 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 PRINTS PR00371 Flavoprotein pyridine nucleotide cytochrome reductase signature 1314 1325 2.7E-25 T 09-03-2017 IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase GO:0016491|GO:0055114 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 PRINTS PR00371 Flavoprotein pyridine nucleotide cytochrome reductase signature 1368 1376 2.7E-25 T 09-03-2017 IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase GO:0016491|GO:0055114 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 PRINTS PR00371 Flavoprotein pyridine nucleotide cytochrome reductase signature 1206 1213 2.7E-25 T 09-03-2017 IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase GO:0016491|GO:0055114 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 PRINTS PR00371 Flavoprotein pyridine nucleotide cytochrome reductase signature 1301 1310 2.7E-25 T 09-03-2017 IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase GO:0016491|GO:0055114 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 PRINTS PR00371 Flavoprotein pyridine nucleotide cytochrome reductase signature 1276 1295 2.7E-25 T 09-03-2017 IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase GO:0016491|GO:0055114 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 PRINTS PR00371 Flavoprotein pyridine nucleotide cytochrome reductase signature 1345 1361 2.7E-25 T 09-03-2017 IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase GO:0016491|GO:0055114 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 Pfam PF00384 Molybdopterin oxidoreductase 97 503 2.4E-71 T 09-03-2017 IPR006656 Molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 Pfam PF01568 Molydopterin dinucleotide binding domain 615 726 2.6E-33 T 09-03-2017 IPR006657 Molybdopterin dinucleotide-binding domain GO:0016491|GO:0030151|GO:0055114 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 Gene3D G3DSA:3.40.228.10 153 336 3.2E-69 T 09-03-2017 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 Gene3D G3DSA:3.40.50.740 75 152 1.2E-77 T 09-03-2017 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 Gene3D G3DSA:3.40.50.740 337 549 1.2E-77 T 09-03-2017 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 Gene3D G3DSA:2.40.40.20 550 732 8.0E-54 T 09-03-2017 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 Gene3D G3DSA:2.20.25.90 13 73 2.3E-18 T 09-03-2017 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 Pfam PF04879 Molybdopterin oxidoreductase Fe4S4 domain 15 70 2.8E-15 T 09-03-2017 IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 Gene3D G3DSA:3.40.50.80 1275 1418 3.1E-56 T 09-03-2017 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 Gene3D G3DSA:2.40.30.10 1204 1274 1.9E-28 T 09-03-2017 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 Gene3D G3DSA:2.40.30.10 1047 1097 1.9E-28 T 09-03-2017 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 SMART SM00926 13 72 6.9E-18 T 09-03-2017 IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 PRINTS PR00369 Flavodoxin signature 875 888 4.1E-13 T 09-03-2017 IPR001094 Flavodoxin-like GO:0010181|GO:0055114 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 PRINTS PR00369 Flavodoxin signature 955 965 4.1E-13 T 09-03-2017 IPR001094 Flavodoxin-like GO:0010181|GO:0055114 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 PRINTS PR00369 Flavodoxin signature 979 998 4.1E-13 T 09-03-2017 IPR001094 Flavodoxin-like GO:0010181|GO:0055114 TK78_RS31285 6dd70666c8104ac29601a50018af2b1b 1419 PRINTS PR00369 Flavodoxin signature 923 934 4.1E-13 T 09-03-2017 IPR001094 Flavodoxin-like GO:0010181|GO:0055114 TK78_RS05345 732444f95731caadb5806a6418c5d878 459 SMART SM00342 98 181 5.2E-20 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS05345 732444f95731caadb5806a6418c5d878 459 SUPERFAMILY SSF46689 135 183 2.42E-8 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS05345 732444f95731caadb5806a6418c5d878 459 SUPERFAMILY SSF57884 2 82 3.53E-31 T 09-03-2017 IPR004026 Ada DNA repair, metal-binding GO:0003677|GO:0006281|GO:0006355|GO:0008168|GO:0008270 TK78_RS05345 732444f95731caadb5806a6418c5d878 459 Gene3D G3DSA:1.10.1670.10 434 448 1.8E-5 T 09-03-2017 IPR023170 Helix-turn-helix, base-excision DNA repair, C-terminal Reactome: R-HSA-110357 TK78_RS05345 732444f95731caadb5806a6418c5d878 459 Pfam PF06029 AlkA N-terminal domain 202 323 2.6E-29 T 09-03-2017 IPR010316 DNA-3-methyladenine glycosylase AlkA, N-terminal TK78_RS05345 732444f95731caadb5806a6418c5d878 459 SMART SM01009 201 323 5.1E-42 T 09-03-2017 IPR010316 DNA-3-methyladenine glycosylase AlkA, N-terminal TK78_RS05345 732444f95731caadb5806a6418c5d878 459 Gene3D G3DSA:3.30.310.20 202 323 2.2E-28 T 09-03-2017 IPR010316 DNA-3-methyladenine glycosylase AlkA, N-terminal TK78_RS05345 732444f95731caadb5806a6418c5d878 459 Pfam PF12833 Helix-turn-helix domain 104 182 1.2E-17 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS05345 732444f95731caadb5806a6418c5d878 459 Gene3D G3DSA:1.10.340.30 335 423 3.8E-11 T 09-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 TK78_RS05345 732444f95731caadb5806a6418c5d878 459 Gene3D G3DSA:3.40.10.10 1 80 2.1E-33 T 09-03-2017 IPR004026 Ada DNA repair, metal-binding GO:0003677|GO:0006281|GO:0006355|GO:0008168|GO:0008270 TK78_RS05345 732444f95731caadb5806a6418c5d878 459 SUPERFAMILY SSF55945 202 304 9.1E-17 T 09-03-2017 TK78_RS05345 732444f95731caadb5806a6418c5d878 459 Pfam PF02805 Metal binding domain of Ada 6 69 2.5E-29 T 09-03-2017 IPR004026 Ada DNA repair, metal-binding GO:0003677|GO:0006281|GO:0006355|GO:0008168|GO:0008270 TK78_RS05345 732444f95731caadb5806a6418c5d878 459 SUPERFAMILY SSF48150 313 448 2.16E-19 T 09-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 TK78_RS05345 732444f95731caadb5806a6418c5d878 459 Gene3D G3DSA:1.10.10.60 135 183 2.5E-10 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS24210 7da5433974c7603d9b501eca519d7859 860 Gene3D G3DSA:1.10.390.10 308 457 8.7E-42 T 09-03-2017 TK78_RS24210 7da5433974c7603d9b501eca519d7859 860 TIGRFAM TIGR02412 pepN_strep_liv: aminopeptidase N 5 852 0.0 T 09-03-2017 IPR012778 Peptidase M1, aminopeptidase GO:0004177|GO:0006508 KEGG: 00480+3.4.11.2|MetaCyc: PWY-4061|MetaCyc: PWY-6842|MetaCyc: PWY-7112 TK78_RS24210 7da5433974c7603d9b501eca519d7859 860 Pfam PF11838 ERAP1-like C-terminal domain 537 846 2.2E-59 T 09-03-2017 IPR024571 ERAP1-like C-terminal domain TK78_RS24210 7da5433974c7603d9b501eca519d7859 860 SUPERFAMILY SSF55486 206 456 1.61E-73 T 09-03-2017 TK78_RS24210 7da5433974c7603d9b501eca519d7859 860 SUPERFAMILY SSF63737 5 195 1.03E-37 T 09-03-2017 TK78_RS24210 7da5433974c7603d9b501eca519d7859 860 Pfam PF01433 Peptidase family M1 95 389 3.8E-72 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS24210 7da5433974c7603d9b501eca519d7859 860 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 314 326 4.5E-23 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS24210 7da5433974c7603d9b501eca519d7859 860 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 295 310 4.5E-23 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS24210 7da5433974c7603d9b501eca519d7859 860 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 178 193 4.5E-23 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS24210 7da5433974c7603d9b501eca519d7859 860 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 261 271 4.5E-23 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS24210 7da5433974c7603d9b501eca519d7859 860 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 135 150 4.5E-23 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS30930 984844119b7db2607914f64589b8afbf 319 Pfam PF00892 EamA-like transporter family 164 300 3.9E-19 T 09-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 TK78_RS30930 984844119b7db2607914f64589b8afbf 319 Pfam PF00892 EamA-like transporter family 15 152 2.8E-12 T 09-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 TK78_RS30930 984844119b7db2607914f64589b8afbf 319 SUPERFAMILY SSF103481 53 155 1.23E-11 T 09-03-2017 TK78_RS30930 984844119b7db2607914f64589b8afbf 319 SUPERFAMILY SSF103481 200 304 6.67E-13 T 09-03-2017 TK78_RS05770 cddbae2cb4ac164795ddc7292f475a83 149 Pfam PF01047 MarR family 39 87 7.6E-9 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS05770 cddbae2cb4ac164795ddc7292f475a83 149 SUPERFAMILY SSF46785 9 145 1.93E-28 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05770 cddbae2cb4ac164795ddc7292f475a83 149 Gene3D G3DSA:1.10.10.10 9 147 2.4E-31 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05770 cddbae2cb4ac164795ddc7292f475a83 149 SMART SM00347 31 131 8.9E-20 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS28435 a9a9720d598ecf849070467383424853 224 SUPERFAMILY SSF46785 7 78 1.64E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS28435 a9a9720d598ecf849070467383424853 224 Gene3D G3DSA:1.20.120.530 90 218 8.2E-26 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS28435 a9a9720d598ecf849070467383424853 224 SUPERFAMILY SSF48008 92 218 3.14E-24 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS28435 a9a9720d598ecf849070467383424853 224 Pfam PF07729 FCD domain 97 216 1.9E-24 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS28435 a9a9720d598ecf849070467383424853 224 Gene3D G3DSA:1.10.10.10 8 77 2.1E-27 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS28435 a9a9720d598ecf849070467383424853 224 SMART SM00895 95 218 3.6E-20 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS28435 a9a9720d598ecf849070467383424853 224 SMART SM00345 15 74 3.2E-20 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS28435 a9a9720d598ecf849070467383424853 224 Pfam PF00392 Bacterial regulatory proteins, gntR family 11 74 1.5E-20 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS28435 a9a9720d598ecf849070467383424853 224 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 34 48 5.1E-9 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS28435 a9a9720d598ecf849070467383424853 224 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 48 64 5.1E-9 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS32105 245058ecf5446b5084fd0734cb7a697e 655 Gene3D G3DSA:2.40.110.10 146 275 5.8E-42 T 09-03-2017 TK78_RS32105 245058ecf5446b5084fd0734cb7a697e 655 Gene3D G3DSA:1.10.540.10 23 144 2.1E-16 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS32105 245058ecf5446b5084fd0734cb7a697e 655 Gene3D G3DSA:1.20.140.10 296 458 2.3E-52 T 09-03-2017 TK78_RS32105 245058ecf5446b5084fd0734cb7a697e 655 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 289 449 1.2E-13 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS32105 245058ecf5446b5084fd0734cb7a697e 655 Pfam PF01756 Acyl-CoA oxidase 512 648 2.7E-21 T 09-03-2017 IPR002655 Acyl-CoA oxidase, C-terminal GO:0003997|GO:0005777|GO:0006635|GO:0055114 KEGG: 00071+1.3.3.6|KEGG: 00592+1.3.3.6|MetaCyc: PWY-5136|MetaCyc: PWY-6837|MetaCyc: PWY-6920|MetaCyc: PWY-7007|MetaCyc: PWY-7288|MetaCyc: PWY-7291|MetaCyc: PWY-7337|MetaCyc: PWY-7338|MetaCyc: PWY-7340|MetaCyc: PWY-735|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS32105 245058ecf5446b5084fd0734cb7a697e 655 SUPERFAMILY SSF56645 18 270 7.07E-55 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS32105 245058ecf5446b5084fd0734cb7a697e 655 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 147 255 1.6E-15 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS32105 245058ecf5446b5084fd0734cb7a697e 655 SUPERFAMILY SSF47203 285 470 1.37E-51 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS32105 245058ecf5446b5084fd0734cb7a697e 655 SUPERFAMILY SSF47203 504 649 1.12E-36 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS32105 245058ecf5446b5084fd0734cb7a697e 655 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 32 143 3.2E-13 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS32105 245058ecf5446b5084fd0734cb7a697e 655 PIRSF PIRSF000168 48 653 5.3E-164 T 09-03-2017 IPR012258 Acyl-CoA oxidase GO:0003997|GO:0005777|GO:0006631|GO:0050660|GO:0055114 KEGG: 00071+1.3.3.6|KEGG: 00592+1.3.3.6|MetaCyc: PWY-5136|MetaCyc: PWY-6837|MetaCyc: PWY-6920|MetaCyc: PWY-7007|MetaCyc: PWY-7288|MetaCyc: PWY-7291|MetaCyc: PWY-7337|MetaCyc: PWY-7338|MetaCyc: PWY-7340|MetaCyc: PWY-735|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS32105 245058ecf5446b5084fd0734cb7a697e 655 Gene3D G3DSA:1.20.140.10 510 640 1.0E-34 T 09-03-2017 TK78_RS24090 f03711378f46a6bac52d339d57a8f70d 134 Gene3D G3DSA:1.10.490.10 11 132 1.3E-45 T 09-03-2017 IPR012292 Globin/Protoglobin GO:0019825|GO:0020037 TK78_RS24090 f03711378f46a6bac52d339d57a8f70d 134 SUPERFAMILY SSF46458 12 132 8.84E-38 T 09-03-2017 IPR009050 Globin-like TK78_RS24090 f03711378f46a6bac52d339d57a8f70d 134 Pfam PF01152 Bacterial-like globin 13 129 2.7E-34 T 09-03-2017 IPR001486 Truncated hemoglobin GO:0019825 TK78_RS33075 a0fd73584e550a682d59f4f6a4bc3688 338 SUPERFAMILY SSF56112 27 292 1.04E-69 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS33075 a0fd73584e550a682d59f4f6a4bc3688 338 Gene3D G3DSA:3.30.200.20 26 93 9.2E-21 T 09-03-2017 TK78_RS33075 a0fd73584e550a682d59f4f6a4bc3688 338 SMART SM00220 29 289 8.3E-56 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS33075 a0fd73584e550a682d59f4f6a4bc3688 338 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 148 160 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS33075 a0fd73584e550a682d59f4f6a4bc3688 338 Gene3D G3DSA:1.10.510.10 94 283 8.2E-46 T 09-03-2017 TK78_RS33075 a0fd73584e550a682d59f4f6a4bc3688 338 Pfam PF00069 Protein kinase domain 31 242 1.3E-43 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS33075 a0fd73584e550a682d59f4f6a4bc3688 338 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 35 58 - T 09-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 TK78_RS13315 cfa90240030e9392338f6d5ba117a004 54 TIGRFAM TIGR01023 rpmG_bact: ribosomal protein bL33 2 54 4.5E-22 T 09-03-2017 IPR001705 Ribosomal protein L33 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13315 cfa90240030e9392338f6d5ba117a004 54 Hamap MF_00294 50S ribosomal protein L33 [rpmG]. 6 54 19.836 T 09-03-2017 IPR001705 Ribosomal protein L33 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13315 cfa90240030e9392338f6d5ba117a004 54 Pfam PF00471 Ribosomal protein L33 9 54 4.1E-23 T 09-03-2017 IPR001705 Ribosomal protein L33 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13315 cfa90240030e9392338f6d5ba117a004 54 ProSitePatterns PS00582 Ribosomal protein L33 signature. 22 41 - T 09-03-2017 IPR018264 Ribosomal protein L33, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13315 cfa90240030e9392338f6d5ba117a004 54 SUPERFAMILY SSF57829 4 54 4.21E-20 T 09-03-2017 IPR011332 Zinc-binding ribosomal protein GO:0006412 TK78_RS20830 c57307152d029aaf7464a5d72cf4807e 775 Gene3D G3DSA:2.20.25.90 46 105 6.7E-18 T 09-03-2017 TK78_RS20830 c57307152d029aaf7464a5d72cf4807e 775 Pfam PF04879 Molybdopterin oxidoreductase Fe4S4 domain 49 101 6.0E-11 T 09-03-2017 IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS20830 c57307152d029aaf7464a5d72cf4807e 775 Gene3D G3DSA:3.40.50.740 106 181 1.2E-71 T 09-03-2017 TK78_RS20830 c57307152d029aaf7464a5d72cf4807e 775 Gene3D G3DSA:3.40.50.740 365 577 1.2E-71 T 09-03-2017 TK78_RS20830 c57307152d029aaf7464a5d72cf4807e 775 Gene3D G3DSA:3.40.228.10 182 364 6.8E-60 T 09-03-2017 TK78_RS20830 c57307152d029aaf7464a5d72cf4807e 775 Pfam PF00384 Molybdopterin oxidoreductase 104 530 6.9E-63 T 09-03-2017 IPR006656 Molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS20830 c57307152d029aaf7464a5d72cf4807e 775 Pfam PF01568 Molydopterin dinucleotide binding domain 624 726 1.2E-21 T 09-03-2017 IPR006657 Molybdopterin dinucleotide-binding domain GO:0016491|GO:0030151|GO:0055114 TK78_RS20830 c57307152d029aaf7464a5d72cf4807e 775 Gene3D G3DSA:2.40.40.20 578 731 7.9E-45 T 09-03-2017 TK78_RS20830 c57307152d029aaf7464a5d72cf4807e 775 SMART SM00926 47 101 2.2E-16 T 09-03-2017 IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS20830 c57307152d029aaf7464a5d72cf4807e 775 SUPERFAMILY SSF50692 589 731 7.23E-38 T 09-03-2017 IPR009010 Aspartate decarboxylase-like domain TK78_RS20830 c57307152d029aaf7464a5d72cf4807e 775 SUPERFAMILY SSF53706 46 624 2.09E-170 T 09-03-2017 TK78_RS20830 c57307152d029aaf7464a5d72cf4807e 775 ProSitePatterns PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 52 69 - T 09-03-2017 IPR027467 Molybdopterin oxidoreductase, molybdopterin cofactor binding site GO:0051539 KEGG: 00910+1.7.99.4 TK78_RS10995 f1a6dd893ff9e738831c278296065b00 539 Gene3D G3DSA:3.10.105.10 324 510 9.0E-40 T 09-03-2017 TK78_RS10995 f1a6dd893ff9e738831c278296065b00 539 Gene3D G3DSA:3.90.76.10 55 214 2.6E-36 T 09-03-2017 TK78_RS10995 f1a6dd893ff9e738831c278296065b00 539 SUPERFAMILY SSF53850 46 534 1.86E-89 T 09-03-2017 TK78_RS10995 f1a6dd893ff9e738831c278296065b00 539 PIRSF PIRSF002741 5 534 1.1E-65 T 09-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 TK78_RS10995 f1a6dd893ff9e738831c278296065b00 539 Gene3D G3DSA:3.40.190.10 215 323 6.1E-22 T 09-03-2017 TK78_RS10995 f1a6dd893ff9e738831c278296065b00 539 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 90 459 2.5E-54 T 09-03-2017 IPR000914 Solute-binding protein family 5 domain TK78_RS13750 a741b1ff91cc25cb4a215b2f180e44dd 689 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 133 145 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS13750 a741b1ff91cc25cb4a215b2f180e44dd 689 Pfam PF00069 Protein kinase domain 15 259 4.3E-39 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS13750 a741b1ff91cc25cb4a215b2f180e44dd 689 SUPERFAMILY SSF56112 12 265 6.2E-65 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS13750 a741b1ff91cc25cb4a215b2f180e44dd 689 Gene3D G3DSA:3.30.200.20 8 80 1.7E-14 T 09-03-2017 TK78_RS13750 a741b1ff91cc25cb4a215b2f180e44dd 689 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 21 43 - T 09-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 TK78_RS13750 a741b1ff91cc25cb4a215b2f180e44dd 689 SMART SM00220 15 265 4.4E-47 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS13750 a741b1ff91cc25cb4a215b2f180e44dd 689 Gene3D G3DSA:1.10.510.10 369 406 2.5E-42 T 09-03-2017 TK78_RS13750 a741b1ff91cc25cb4a215b2f180e44dd 689 Gene3D G3DSA:1.10.510.10 99 265 2.5E-42 T 09-03-2017 TK78_RS29290 40cfb870b8c01f6e11dc81dcdf3a6c10 1171 Pfam PF02574 Homocysteine S-methyltransferase 27 316 1.4E-61 T 09-03-2017 IPR003726 Homocysteine-binding domain Reactome: R-HSA-1614635 TK78_RS29290 40cfb870b8c01f6e11dc81dcdf3a6c10 1171 Gene3D G3DSA:1.10.1240.10 643 727 1.9E-31 T 09-03-2017 IPR003759 Cobalamin (vitamin B12)-binding module, cap domain Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TK78_RS29290 40cfb870b8c01f6e11dc81dcdf3a6c10 1171 SUPERFAMILY SSF47644 648 729 6.93E-24 T 09-03-2017 IPR003759 Cobalamin (vitamin B12)-binding module, cap domain Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TK78_RS29290 40cfb870b8c01f6e11dc81dcdf3a6c10 1171 SUPERFAMILY SSF51717 350 621 2.22E-71 T 09-03-2017 IPR011005 Dihydropteroate synthase-like GO:0044237 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TK78_RS29290 40cfb870b8c01f6e11dc81dcdf3a6c10 1171 Gene3D G3DSA:3.40.50.280 733 863 3.1E-46 T 09-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 TK78_RS29290 40cfb870b8c01f6e11dc81dcdf3a6c10 1171 TIGRFAM TIGR02082 metH: methionine synthase 23 1169 0.0 T 09-03-2017 IPR011822 Cobalamin-dependent methionine synthase GO:0008270|GO:0008705|GO:0008898|GO:0009086|GO:0031419 KEGG: 00270+2.1.1.13|KEGG: 00450+2.1.1.13|KEGG: 00670+2.1.1.13|MetaCyc: PWY-2201|MetaCyc: PWY-3841|Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TK78_RS29290 40cfb870b8c01f6e11dc81dcdf3a6c10 1171 Pfam PF02965 Vitamin B12 dependent methionine synthase, activation domain 969 1169 1.1E-39 T 09-03-2017 IPR004223 Vitamin B12-dependent methionine synthase, activation domain GO:0005622|GO:0008705|GO:0009086 KEGG: 00270+2.1.1.13|KEGG: 00450+2.1.1.13|KEGG: 00670+2.1.1.13|MetaCyc: PWY-2201|MetaCyc: PWY-3841|Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TK78_RS29290 40cfb870b8c01f6e11dc81dcdf3a6c10 1171 Pfam PF02607 B12 binding domain 651 723 8.5E-26 T 09-03-2017 IPR003759 Cobalamin (vitamin B12)-binding module, cap domain Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TK78_RS29290 40cfb870b8c01f6e11dc81dcdf3a6c10 1171 Pfam PF02310 B12 binding domain 736 852 1.9E-20 T 09-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 TK78_RS29290 40cfb870b8c01f6e11dc81dcdf3a6c10 1171 SUPERFAMILY SSF82282 18 392 9.68E-99 T 09-03-2017 IPR003726 Homocysteine-binding domain Reactome: R-HSA-1614635 TK78_RS29290 40cfb870b8c01f6e11dc81dcdf3a6c10 1171 Gene3D G3DSA:3.20.20.330 14 357 3.1E-98 T 09-03-2017 IPR003726 Homocysteine-binding domain Reactome: R-HSA-1614635 TK78_RS29290 40cfb870b8c01f6e11dc81dcdf3a6c10 1171 SMART SM01018 648 730 6.3E-41 T 09-03-2017 IPR003759 Cobalamin (vitamin B12)-binding module, cap domain Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TK78_RS29290 40cfb870b8c01f6e11dc81dcdf3a6c10 1171 Gene3D G3DSA:3.10.196.10 951 1169 1.1E-71 T 09-03-2017 IPR004223 Vitamin B12-dependent methionine synthase, activation domain GO:0005622|GO:0008705|GO:0009086 KEGG: 00270+2.1.1.13|KEGG: 00450+2.1.1.13|KEGG: 00670+2.1.1.13|MetaCyc: PWY-2201|MetaCyc: PWY-3841|Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TK78_RS29290 40cfb870b8c01f6e11dc81dcdf3a6c10 1171 Gene3D G3DSA:3.20.20.20 358 620 8.3E-82 T 09-03-2017 IPR000489 Pterin-binding domain GO:0042558 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TK78_RS29290 40cfb870b8c01f6e11dc81dcdf3a6c10 1171 Pfam PF00809 Pterin binding enzyme 353 589 5.9E-44 T 09-03-2017 IPR000489 Pterin-binding domain GO:0042558 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TK78_RS29290 40cfb870b8c01f6e11dc81dcdf3a6c10 1171 PIRSF PIRSF000381 11 1171 0.0 T 09-03-2017 IPR011822 Cobalamin-dependent methionine synthase GO:0008270|GO:0008705|GO:0008898|GO:0009086|GO:0031419 KEGG: 00270+2.1.1.13|KEGG: 00450+2.1.1.13|KEGG: 00670+2.1.1.13|MetaCyc: PWY-2201|MetaCyc: PWY-3841|Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TK78_RS29290 40cfb870b8c01f6e11dc81dcdf3a6c10 1171 SUPERFAMILY SSF56507 897 1170 1.83E-92 T 09-03-2017 IPR004223 Vitamin B12-dependent methionine synthase, activation domain GO:0005622|GO:0008705|GO:0009086 KEGG: 00270+2.1.1.13|KEGG: 00450+2.1.1.13|KEGG: 00670+2.1.1.13|MetaCyc: PWY-2201|MetaCyc: PWY-3841|Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TK78_RS29290 40cfb870b8c01f6e11dc81dcdf3a6c10 1171 SUPERFAMILY SSF52242 731 865 8.9E-38 T 09-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 TK78_RS18700 1253f6d7d14ad74b29eea76f7e44ad81 607 Pfam PF02872 5'-nucleotidase, C-terminal domain 413 566 2.4E-39 T 09-03-2017 IPR008334 5'-Nucleotidase, C-terminal GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 TK78_RS18700 1253f6d7d14ad74b29eea76f7e44ad81 607 SUPERFAMILY SSF55816 400 606 3.01E-46 T 09-03-2017 IPR008334 5'-Nucleotidase, C-terminal GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 TK78_RS18700 1253f6d7d14ad74b29eea76f7e44ad81 607 Pfam PF00149 Calcineurin-like phosphoesterase 62 318 5.0E-6 T 09-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 TK78_RS18700 1253f6d7d14ad74b29eea76f7e44ad81 607 Gene3D G3DSA:3.60.21.10 51 395 3.4E-79 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS18700 1253f6d7d14ad74b29eea76f7e44ad81 607 Gene3D G3DSA:3.90.780.10 400 606 5.5E-49 T 09-03-2017 IPR008334 5'-Nucleotidase, C-terminal GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 TK78_RS18700 1253f6d7d14ad74b29eea76f7e44ad81 607 SUPERFAMILY SSF56300 52 396 3.28E-68 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS18700 1253f6d7d14ad74b29eea76f7e44ad81 607 PRINTS PR01607 Apyrase family signature 55 73 1.7E-16 T 09-03-2017 IPR006179 5'-Nucleotidase/apyrase GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 TK78_RS18700 1253f6d7d14ad74b29eea76f7e44ad81 607 PRINTS PR01607 Apyrase family signature 464 487 1.7E-16 T 09-03-2017 IPR006179 5'-Nucleotidase/apyrase GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 TK78_RS18700 1253f6d7d14ad74b29eea76f7e44ad81 607 PRINTS PR01607 Apyrase family signature 301 324 1.7E-16 T 09-03-2017 IPR006179 5'-Nucleotidase/apyrase GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 TK78_RS18700 1253f6d7d14ad74b29eea76f7e44ad81 607 PRINTS PR01607 Apyrase family signature 540 559 1.7E-16 T 09-03-2017 IPR006179 5'-Nucleotidase/apyrase GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 TK78_RS11435 23fbf4085353c9f741595306afdff3e9 867 Gene3D G3DSA:3.40.50.980 291 425 8.6E-41 T 09-03-2017 TK78_RS11435 23fbf4085353c9f741595306afdff3e9 867 Gene3D G3DSA:3.30.300.30 672 801 5.6E-28 T 09-03-2017 TK78_RS11435 23fbf4085353c9f741595306afdff3e9 867 Gene3D G3DSA:2.30.38.10 590 665 1.3E-25 T 09-03-2017 TK78_RS11435 23fbf4085353c9f741595306afdff3e9 867 Pfam PF00501 AMP-binding enzyme 294 677 1.2E-90 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS11435 23fbf4085353c9f741595306afdff3e9 867 Gene3D G3DSA:3.40.50.980 426 589 6.6E-45 T 09-03-2017 TK78_RS11435 23fbf4085353c9f741595306afdff3e9 867 SUPERFAMILY SSF56801 276 775 4.45E-144 T 09-03-2017 TK78_RS11435 23fbf4085353c9f741595306afdff3e9 867 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 315 701 1.3E-121 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS11435 23fbf4085353c9f741595306afdff3e9 867 Pfam PF13193 AMP-binding enzyme C-terminal domain 685 763 4.7E-9 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS11435 23fbf4085353c9f741595306afdff3e9 867 Pfam PF00550 Phosphopantetheine attachment site 800 863 6.5E-8 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS11435 23fbf4085353c9f741595306afdff3e9 867 ProSitePatterns PS00455 Putative AMP-binding domain signature. 416 427 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS11435 23fbf4085353c9f741595306afdff3e9 867 Gene3D G3DSA:1.10.1200.10 802 864 6.9E-17 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS11435 23fbf4085353c9f741595306afdff3e9 867 SUPERFAMILY SSF47336 799 863 5.76E-13 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS09260 9f17151c65b604f21f758e4cbd301696 763 Gene3D G3DSA:2.60.40.10 54 212 4.2E-50 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS09260 9f17151c65b604f21f758e4cbd301696 763 SUPERFAMILY SSF81296 54 207 8.2E-39 T 09-03-2017 IPR014756 Immunoglobulin E-set TK78_RS09260 9f17151c65b604f21f758e4cbd301696 763 Pfam PF00128 Alpha amylase, catalytic domain 248 337 5.6E-6 T 09-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 TK78_RS09260 9f17151c65b604f21f758e4cbd301696 763 SUPERFAMILY SSF51445 559 637 1.7E-131 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS09260 9f17151c65b604f21f758e4cbd301696 763 SUPERFAMILY SSF51445 193 530 1.7E-131 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS09260 9f17151c65b604f21f758e4cbd301696 763 Gene3D G3DSA:3.20.20.80 213 638 2.5E-121 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS09260 9f17151c65b604f21f758e4cbd301696 763 Gene3D G3DSA:2.60.40.1180 649 760 2.7E-23 T 09-03-2017 IPR013780 Glycosyl hydrolase, all-beta TK78_RS09260 9f17151c65b604f21f758e4cbd301696 763 SMART SM00642 218 622 4.1E-8 T 09-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 TK78_RS09260 9f17151c65b604f21f758e4cbd301696 763 SUPERFAMILY SSF51011 650 760 2.16E-18 T 09-03-2017 TK78_RS09260 9f17151c65b604f21f758e4cbd301696 763 TIGRFAM TIGR02100 glgX_debranch: glycogen debranching enzyme GlgX 55 760 0.0 T 09-03-2017 IPR011837 Glycogen debranching enzyme, GlgX type GO:0004133|GO:0004553|GO:0005980 TK78_RS09260 9f17151c65b604f21f758e4cbd301696 763 Pfam PF02922 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) 59 150 3.1E-19 T 09-03-2017 IPR004193 Glycoside hydrolase, family 13, N-terminal GO:0004553|GO:0005975 Reactome: R-HSA-3322077|Reactome: R-HSA-3878781 TK78_RS02105 a1051b9fc6457a4f30dfb8c4612321f2 481 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 13 328 8.0E-47 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS02105 a1051b9fc6457a4f30dfb8c4612321f2 481 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 184 202 3.1E-20 T 09-03-2017 TK78_RS02105 a1051b9fc6457a4f30dfb8c4612321f2 481 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 298 320 3.1E-20 T 09-03-2017 TK78_RS02105 a1051b9fc6457a4f30dfb8c4612321f2 481 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 145 163 3.1E-20 T 09-03-2017 TK78_RS02105 a1051b9fc6457a4f30dfb8c4612321f2 481 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 270 286 3.1E-20 T 09-03-2017 TK78_RS02105 a1051b9fc6457a4f30dfb8c4612321f2 481 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 15 34 3.1E-20 T 09-03-2017 TK78_RS02105 a1051b9fc6457a4f30dfb8c4612321f2 481 Pfam PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 366 472 1.2E-21 T 09-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 TK78_RS02105 a1051b9fc6457a4f30dfb8c4612321f2 481 Gene3D G3DSA:3.50.50.60 13 151 1.6E-27 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS02105 a1051b9fc6457a4f30dfb8c4612321f2 481 PIRSF PIRSF000350 2 480 3.8E-65 T 09-03-2017 TK78_RS02105 a1051b9fc6457a4f30dfb8c4612321f2 481 SUPERFAMILY SSF55424 362 479 1.32E-26 T 09-03-2017 IPR016156 FAD/NAD-linked reductase, dimerisation domain GO:0016491|GO:0050660|GO:0055114 TK78_RS02105 a1051b9fc6457a4f30dfb8c4612321f2 481 Gene3D G3DSA:3.30.390.30 361 479 6.9E-27 T 09-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 TK78_RS02105 a1051b9fc6457a4f30dfb8c4612321f2 481 SUPERFAMILY SSF51905 11 343 9.72E-45 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS02105 a1051b9fc6457a4f30dfb8c4612321f2 481 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 14 36 2.9E-52 T 09-03-2017 TK78_RS02105 a1051b9fc6457a4f30dfb8c4612321f2 481 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 313 320 2.9E-52 T 09-03-2017 TK78_RS02105 a1051b9fc6457a4f30dfb8c4612321f2 481 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 450 470 2.9E-52 T 09-03-2017 TK78_RS02105 a1051b9fc6457a4f30dfb8c4612321f2 481 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 184 209 2.9E-52 T 09-03-2017 TK78_RS02105 a1051b9fc6457a4f30dfb8c4612321f2 481 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 271 285 2.9E-52 T 09-03-2017 TK78_RS02105 a1051b9fc6457a4f30dfb8c4612321f2 481 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 46 61 2.9E-52 T 09-03-2017 TK78_RS02105 a1051b9fc6457a4f30dfb8c4612321f2 481 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 428 443 2.9E-52 T 09-03-2017 TK78_RS02105 a1051b9fc6457a4f30dfb8c4612321f2 481 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 148 157 2.9E-52 T 09-03-2017 TK78_RS02105 a1051b9fc6457a4f30dfb8c4612321f2 481 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 362 383 2.9E-52 T 09-03-2017 TK78_RS02105 a1051b9fc6457a4f30dfb8c4612321f2 481 Gene3D G3DSA:3.50.50.60 152 341 1.3E-35 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS20800 60365fd27086613275686f042b26d10b 333 Gene3D G3DSA:1.10.10.10 264 325 6.4E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS20800 60365fd27086613275686f042b26d10b 333 SUPERFAMILY SSF88946 34 171 1.19E-46 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS20800 60365fd27086613275686f042b26d10b 333 Gene3D G3DSA:1.10.10.10 174 225 7.1E-15 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS20800 60365fd27086613275686f042b26d10b 333 ProSitePatterns PS00715 Sigma-70 factors family signature 1. 125 138 - T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS20800 60365fd27086613275686f042b26d10b 333 Gene3D G3DSA:1.10.601.10 22 170 1.1E-55 T 09-03-2017 TK78_RS20800 60365fd27086613275686f042b26d10b 333 Pfam PF04539 Sigma-70 region 3 180 256 3.9E-23 T 09-03-2017 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS20800 60365fd27086613275686f042b26d10b 333 SUPERFAMILY SSF88659 232 326 1.83E-23 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS20800 60365fd27086613275686f042b26d10b 333 Pfam PF00140 Sigma-70 factor, region 1.2 34 67 2.0E-10 T 09-03-2017 IPR009042 RNA polymerase sigma-70 region 1.2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS20800 60365fd27086613275686f042b26d10b 333 Pfam PF04542 Sigma-70 region 2 101 171 5.2E-20 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS20800 60365fd27086613275686f042b26d10b 333 PRINTS PR00046 Major sigma-70 factor signature 309 320 7.3E-25 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS20800 60365fd27086613275686f042b26d10b 333 PRINTS PR00046 Major sigma-70 factor signature 125 138 7.3E-25 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS20800 60365fd27086613275686f042b26d10b 333 PRINTS PR00046 Major sigma-70 factor signature 273 285 7.3E-25 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS20800 60365fd27086613275686f042b26d10b 333 PRINTS PR00046 Major sigma-70 factor signature 294 309 7.3E-25 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS20800 60365fd27086613275686f042b26d10b 333 PRINTS PR00046 Major sigma-70 factor signature 149 157 7.3E-25 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS20800 60365fd27086613275686f042b26d10b 333 SUPERFAMILY SSF88659 174 247 4.71E-16 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS20800 60365fd27086613275686f042b26d10b 333 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 98 322 1.3E-32 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS20800 60365fd27086613275686f042b26d10b 333 ProSitePatterns PS00716 Sigma-70 factors family signature 2. 294 320 - T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS20800 60365fd27086613275686f042b26d10b 333 Pfam PF04545 Sigma-70, region 4 270 321 1.1E-13 T 09-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS15410 8e029ba81c73d074ead788f938809c12 401 Gene3D G3DSA:2.40.10.10 293 385 1.8E-12 T 09-03-2017 TK78_RS15410 8e029ba81c73d074ead788f938809c12 401 Gene3D G3DSA:2.40.10.10 219 292 5.0E-14 T 09-03-2017 TK78_RS15410 8e029ba81c73d074ead788f938809c12 401 Pfam PF02674 Colicin V production protein 4 147 1.3E-18 T 09-03-2017 IPR003825 Colicin V production, CvpA GO:0009403|GO:0016020 TK78_RS15410 8e029ba81c73d074ead788f938809c12 401 PRINTS PR00834 HtrA/DegQ protease family signature 228 240 6.2E-10 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS15410 8e029ba81c73d074ead788f938809c12 401 PRINTS PR00834 HtrA/DegQ protease family signature 250 270 6.2E-10 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS15410 8e029ba81c73d074ead788f938809c12 401 PRINTS PR00834 HtrA/DegQ protease family signature 291 315 6.2E-10 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS15410 8e029ba81c73d074ead788f938809c12 401 PRINTS PR00834 HtrA/DegQ protease family signature 331 348 6.2E-10 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS15410 8e029ba81c73d074ead788f938809c12 401 SUPERFAMILY SSF50494 196 384 6.22E-36 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS15410 8e029ba81c73d074ead788f938809c12 401 Pfam PF13365 Trypsin-like peptidase domain 220 360 5.8E-22 T 09-03-2017 TK78_RS09700 2bd37db771e82e6ff1ff2d7b0a97c574 277 ProSitePatterns PS00449 ATP synthase a subunit signature. 200 209 - T 09-03-2017 IPR023011 ATPase, F0 complex, subunit A, active site Reactome: R-HSA-163210 TK78_RS09700 2bd37db771e82e6ff1ff2d7b0a97c574 277 Pfam PF00119 ATP synthase A chain 56 270 2.9E-47 T 09-03-2017 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 Reactome: R-HSA-163210 TK78_RS09700 2bd37db771e82e6ff1ff2d7b0a97c574 277 Gene3D G3DSA:1.20.120.220 103 275 1.2E-39 T 09-03-2017 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 Reactome: R-HSA-163210 TK78_RS09700 2bd37db771e82e6ff1ff2d7b0a97c574 277 PRINTS PR00123 ATP synthase A subunit signature 197 219 6.6E-19 T 09-03-2017 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 Reactome: R-HSA-163210 TK78_RS09700 2bd37db771e82e6ff1ff2d7b0a97c574 277 PRINTS PR00123 ATP synthase A subunit signature 256 271 6.6E-19 T 09-03-2017 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 Reactome: R-HSA-163210 TK78_RS09700 2bd37db771e82e6ff1ff2d7b0a97c574 277 PRINTS PR00123 ATP synthase A subunit signature 112 128 6.6E-19 T 09-03-2017 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 Reactome: R-HSA-163210 TK78_RS09700 2bd37db771e82e6ff1ff2d7b0a97c574 277 TIGRFAM TIGR01131 ATP_synt_6_or_A: ATP synthase F0, A subunit 43 272 6.2E-45 T 09-03-2017 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 Reactome: R-HSA-163210 TK78_RS09700 2bd37db771e82e6ff1ff2d7b0a97c574 277 SUPERFAMILY SSF81336 103 270 2.62E-36 T 09-03-2017 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 Reactome: R-HSA-163210 TK78_RS09700 2bd37db771e82e6ff1ff2d7b0a97c574 277 Hamap MF_01393 ATP synthase subunit a [atpB]. 1 276 13.289 T 09-03-2017 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 Reactome: R-HSA-163210 TK78_RS25335 286c837f8784a12566b359af86520fee 76 Gene3D G3DSA:3.90.1490.10 26 60 7.6E-4 T 09-03-2017 TK78_RS25335 286c837f8784a12566b359af86520fee 76 Pfam PF09957 Bacterial antitoxin of type II TA system, VapB 4 43 1.2E-14 T 09-03-2017 IPR019239 Bacterial antitoxin of type II TA system, VapB TK78_RS26330 11c571bef8fced1ab218c631452c9d7c 263 TIGRFAM TIGR03704 PrmC_rel_meth: putative protein-(glutamine-N5) methyltransferase, unknown substrate-specific 14 259 1.9E-117 T 09-03-2017 IPR022446 Conserved hypothetical protein CHP03704, protein-(glutamine-N5) methyltransferase TK78_RS26330 11c571bef8fced1ab218c631452c9d7c 263 SUPERFAMILY SSF53335 49 226 5.25E-42 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS26330 11c571bef8fced1ab218c631452c9d7c 263 Pfam PF05175 Methyltransferase small domain 82 200 4.4E-12 T 09-03-2017 IPR007848 Methyltransferase small domain GO:0008168 TK78_RS26330 11c571bef8fced1ab218c631452c9d7c 263 TIGRFAM TIGR00536 hemK_fam: methyltransferase, HemK family 41 237 1.3E-43 T 09-03-2017 IPR004556 Modification methylase HemK GO:0006479|GO:0008276 TK78_RS26330 11c571bef8fced1ab218c631452c9d7c 263 Gene3D G3DSA:3.40.50.150 73 243 8.4E-47 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS26330 11c571bef8fced1ab218c631452c9d7c 263 Gene3D G3DSA:1.10.8.10 12 71 1.4E-6 T 09-03-2017 TK78_RS03095 f0397c8d18eef345cb95adfb17f7833c 458 Gene3D G3DSA:3.80.30.20 47 261 1.6E-23 T 09-03-2017 IPR023404 Radical SAM, alpha/beta horseshoe TK78_RS03095 f0397c8d18eef345cb95adfb17f7833c 458 SMART SM00729 46 272 4.5E-35 T 09-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 TK78_RS03095 f0397c8d18eef345cb95adfb17f7833c 458 SUPERFAMILY SSF102114 9 444 2.62E-71 T 09-03-2017 TK78_RS03095 f0397c8d18eef345cb95adfb17f7833c 458 Pfam PF04055 Radical SAM superfamily 52 225 1.8E-15 T 09-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 TK78_RS07190 003c78a5b071591f831e77db8cb83879 271 SUPERFAMILY SSF51261 68 264 6.28E-44 T 09-03-2017 IPR011055 Duplicated hybrid motif TK78_RS07190 003c78a5b071591f831e77db8cb83879 271 Pfam PF01551 Peptidase family M23 163 259 8.2E-31 T 09-03-2017 IPR016047 Peptidase M23 TK78_RS07190 003c78a5b071591f831e77db8cb83879 271 Gene3D G3DSA:2.70.70.10 112 265 3.1E-44 T 09-03-2017 TK78_RS34635 2f7c71fd91d26d2bdcab1a968ac86f9e 117 Gene3D G3DSA:3.30.40.10 11 81 2.8E-20 T 09-03-2017 IPR013083 Zinc finger, RING/FYVE/PHD-type TK78_RS34635 2f7c71fd91d26d2bdcab1a968ac86f9e 117 SUPERFAMILY SSF57850 12 82 8.48E-25 T 09-03-2017 TK78_RS34635 2f7c71fd91d26d2bdcab1a968ac86f9e 117 Pfam PF02148 Zn-finger in ubiquitin-hydrolases and other protein 18 80 1.6E-11 T 09-03-2017 IPR001607 Zinc finger, UBP-type GO:0008270 TK78_RS01360 1313f90a76dae15d4e7e6bf6c23906ae 308 Pfam PF01040 UbiA prenyltransferase family 53 273 1.6E-17 T 09-03-2017 IPR000537 UbiA prenyltransferase family GO:0004659|GO:0016021 TK78_RS22475 f761bfcd9789e5fcdfd48d63a16ef872 594 SMART SM00487 22 198 1.1E-16 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS22475 f761bfcd9789e5fcdfd48d63a16ef872 594 Pfam PF04851 Type III restriction enzyme, res subunit 25 176 8.5E-13 T 09-03-2017 IPR006935 Helicase/UvrB, N-terminal GO:0003677|GO:0005524|GO:0016787 TK78_RS22475 f761bfcd9789e5fcdfd48d63a16ef872 594 Gene3D G3DSA:3.40.50.300 283 388 4.9E-8 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22475 f761bfcd9789e5fcdfd48d63a16ef872 594 SUPERFAMILY SSF52540 20 180 3.84E-25 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22475 f761bfcd9789e5fcdfd48d63a16ef872 594 SUPERFAMILY SSF52540 265 388 9.08E-17 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22475 f761bfcd9789e5fcdfd48d63a16ef872 594 SUPERFAMILY SSF52540 138 210 9.08E-17 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22475 f761bfcd9789e5fcdfd48d63a16ef872 594 Gene3D G3DSA:3.40.50.300 24 179 6.2E-18 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33580 30bb7c85c7f74d87d901202639467400 327 Gene3D G3DSA:3.30.70.270 17 94 1.5E-6 T 09-03-2017 TK78_RS33580 30bb7c85c7f74d87d901202639467400 327 SUPERFAMILY SSF56672 15 171 3.0E-31 T 09-03-2017 TK78_RS33580 30bb7c85c7f74d87d901202639467400 327 Pfam PF00817 impB/mucB/samB family 17 87 2.2E-6 T 09-03-2017 IPR001126 UmuC domain GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7|Reactome: R-HSA-5656169 TK78_RS33580 30bb7c85c7f74d87d901202639467400 327 Gene3D G3DSA:1.10.150.20 101 174 5.6E-18 T 09-03-2017 TK78_RS33580 30bb7c85c7f74d87d901202639467400 327 Pfam PF11799 impB/mucB/samB family C-terminal domain 177 288 4.0E-11 T 09-03-2017 IPR017961 DNA polymerase, Y-family, little finger domain GO:0003684|GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7|Reactome: R-HSA-5656169 TK78_RS33580 30bb7c85c7f74d87d901202639467400 327 Gene3D G3DSA:3.30.1490.100 182 286 2.2E-11 T 09-03-2017 IPR017961 DNA polymerase, Y-family, little finger domain GO:0003684|GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7|Reactome: R-HSA-5656169 TK78_RS33580 30bb7c85c7f74d87d901202639467400 327 SUPERFAMILY SSF100879 177 277 3.92E-10 T 09-03-2017 IPR017961 DNA polymerase, Y-family, little finger domain GO:0003684|GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7|Reactome: R-HSA-5656169 TK78_RS12450 3e5b8de519d6d81824dab45300df995d 466 Pfam PF00155 Aminotransferase class I and II 122 408 2.4E-16 T 09-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TK78_RS12450 3e5b8de519d6d81824dab45300df995d 466 Gene3D G3DSA:1.10.10.10 25 91 1.6E-24 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS12450 3e5b8de519d6d81824dab45300df995d 466 SUPERFAMILY SSF53383 79 465 1.51E-72 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS12450 3e5b8de519d6d81824dab45300df995d 466 Gene3D G3DSA:3.40.640.10 137 356 1.0E-43 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS12450 3e5b8de519d6d81824dab45300df995d 466 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 58 74 2.0E-6 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS12450 3e5b8de519d6d81824dab45300df995d 466 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 44 58 2.0E-6 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS12450 3e5b8de519d6d81824dab45300df995d 466 SUPERFAMILY SSF46785 22 93 5.45E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS12450 3e5b8de519d6d81824dab45300df995d 466 Pfam PF00392 Bacterial regulatory proteins, gntR family 25 84 1.0E-18 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS12450 3e5b8de519d6d81824dab45300df995d 466 SMART SM00345 25 84 4.5E-19 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS23245 3e7386cf402d4105172b2b44c20d1586 328 ProSitePatterns PS00583 pfkB family of carbohydrate kinases signature 1. 47 71 - T 09-03-2017 IPR002173 Carbohydrate/puine kinase, PfkB, conserved site GO:0016773 TK78_RS23245 3e7386cf402d4105172b2b44c20d1586 328 Gene3D G3DSA:3.40.1190.20 2 307 4.6E-49 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS23245 3e7386cf402d4105172b2b44c20d1586 328 SUPERFAMILY SSF53613 2 296 2.18E-54 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS23245 3e7386cf402d4105172b2b44c20d1586 328 Pfam PF00294 pfkB family carbohydrate kinase 32 295 1.0E-39 T 09-03-2017 IPR011611 Carbohydrate kinase PfkB TK78_RS14320 4a1c38be531f7fe52e76f30804bbcd67 185 SUPERFAMILY SSF55729 11 171 1.68E-19 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS14320 4a1c38be531f7fe52e76f30804bbcd67 185 Gene3D G3DSA:3.40.630.30 6 172 2.2E-25 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS14320 4a1c38be531f7fe52e76f30804bbcd67 185 Pfam PF13302 Acetyltransferase (GNAT) domain 24 161 3.4E-14 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS11415 d8071003cb29da8de3e6b75c1646f756 1900 TIGRFAM TIGR04020 seco_metab_LLM: natural product biosynthesis luciferase-like monooxygenase domain 553 884 5.6E-128 T 09-03-2017 IPR024011 Natural product biosynthesis luciferase-like monooxygenase domain TK78_RS11415 d8071003cb29da8de3e6b75c1646f756 1900 Pfam PF00550 Phosphopantetheine attachment site 1364 1425 1.2E-13 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS11415 d8071003cb29da8de3e6b75c1646f756 1900 Pfam PF00202 Aminotransferase class-III 120 476 8.8E-50 T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS11415 d8071003cb29da8de3e6b75c1646f756 1900 SUPERFAMILY SSF47336 1357 1427 9.42E-16 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS11415 d8071003cb29da8de3e6b75c1646f756 1900 Gene3D G3DSA:3.20.20.30 532 881 6.4E-72 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS11415 d8071003cb29da8de3e6b75c1646f756 1900 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1385 1400 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS11415 d8071003cb29da8de3e6b75c1646f756 1900 SUPERFAMILY SSF52777 1634 1883 1.22E-28 T 09-03-2017 TK78_RS11415 d8071003cb29da8de3e6b75c1646f756 1900 SUPERFAMILY SSF51679 533 879 7.46E-66 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS11415 d8071003cb29da8de3e6b75c1646f756 1900 Pfam PF00296 Luciferase-like monooxygenase 554 859 9.9E-48 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS11415 d8071003cb29da8de3e6b75c1646f756 1900 SMART SM00823 Phosphopantetheine attachment site 1361 1430 4.8E-10 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS11415 d8071003cb29da8de3e6b75c1646f756 1900 Pfam PF00668 Condensation domain 903 1192 2.4E-47 T 09-03-2017 IPR001242 Condensation domain TK78_RS11415 d8071003cb29da8de3e6b75c1646f756 1900 Pfam PF00668 Condensation domain 1440 1737 2.1E-46 T 09-03-2017 IPR001242 Condensation domain TK78_RS11415 d8071003cb29da8de3e6b75c1646f756 1900 SUPERFAMILY SSF52777 1445 1624 7.56E-40 T 09-03-2017 TK78_RS11415 d8071003cb29da8de3e6b75c1646f756 1900 Gene3D G3DSA:3.90.1150.10 82 155 2.7E-32 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS11415 d8071003cb29da8de3e6b75c1646f756 1900 Gene3D G3DSA:3.90.1150.10 415 503 2.7E-32 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS11415 d8071003cb29da8de3e6b75c1646f756 1900 SUPERFAMILY SSF53383 90 504 2.74E-85 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS11415 d8071003cb29da8de3e6b75c1646f756 1900 SUPERFAMILY SSF52777 1085 1323 2.15E-37 T 09-03-2017 TK78_RS11415 d8071003cb29da8de3e6b75c1646f756 1900 Gene3D G3DSA:1.10.1200.10 1351 1429 5.7E-20 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS11415 d8071003cb29da8de3e6b75c1646f756 1900 Pfam PF13745 HxxPF-repeated domain 1216 1304 1.3E-11 T 09-03-2017 TK78_RS11415 d8071003cb29da8de3e6b75c1646f756 1900 Gene3D G3DSA:3.40.640.10 157 411 6.4E-61 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS11415 d8071003cb29da8de3e6b75c1646f756 1900 SUPERFAMILY SSF52777 903 1096 1.33E-38 T 09-03-2017 TK78_RS22260 1036128d64e718a8e20e2b72592469af 229 SMART SM00382 28 215 1.9E-15 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS22260 1036128d64e718a8e20e2b72592469af 229 ProSitePatterns PS00211 ABC transporters family signature. 139 153 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS22260 1036128d64e718a8e20e2b72592469af 229 Pfam PF00005 ABC transporter 19 166 6.8E-34 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS22260 1036128d64e718a8e20e2b72592469af 229 Gene3D G3DSA:3.40.50.300 1 219 1.2E-72 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22260 1036128d64e718a8e20e2b72592469af 229 SUPERFAMILY SSF52540 1 220 6.34E-70 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22260 1036128d64e718a8e20e2b72592469af 229 TIGRFAM TIGR02673 FtsE: cell division ATP-binding protein FtsE 1 215 7.6E-86 T 09-03-2017 IPR005286 Cell division protein FtsE, ATP-binding GO:0005524|GO:0051301 TK78_RS13625 aa83e3763a5bc6014ae5a9af511750f2 231 Gene3D G3DSA:1.10.1060.10 32 152 2.8E-19 T 09-03-2017 TK78_RS13625 aa83e3763a5bc6014ae5a9af511750f2 231 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 122 133 - T 09-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TK78_RS13625 aa83e3763a5bc6014ae5a9af511750f2 231 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 77 88 - T 09-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TK78_RS13625 aa83e3763a5bc6014ae5a9af511750f2 231 TIGRFAM TIGR01971 NuoI: NADH-quinone oxidoreductase, chain I 33 160 1.5E-43 T 09-03-2017 IPR010226 NADH-quinone oxidoreductase, chain I GO:0016020|GO:0016651|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13625 aa83e3763a5bc6014ae5a9af511750f2 231 Pfam PF12838 4Fe-4S dicluster domain 76 136 4.0E-11 T 09-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TK78_RS13625 aa83e3763a5bc6014ae5a9af511750f2 231 SUPERFAMILY SSF54862 50 166 4.18E-26 T 09-03-2017 TK78_RS13625 aa83e3763a5bc6014ae5a9af511750f2 231 Hamap MF_01351 NAD(P)H-quinone oxidoreductase subunit I, chloroplastic [ndhI]. 24 166 27.853 T 09-03-2017 IPR010226 NADH-quinone oxidoreductase, chain I GO:0016020|GO:0016651|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS08260 ffa14e63ba74a48079f2042c4e3d2e60 286 Gene3D G3DSA:1.10.8.50 141 280 1.4E-45 T 09-03-2017 TK78_RS08260 ffa14e63ba74a48079f2042c4e3d2e60 286 SMART SM01232 139 231 3.0E-40 T 09-03-2017 IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding GO:0003684|GO:0003906|GO:0006289|GO:0008270|GO:0016799 TK78_RS08260 ffa14e63ba74a48079f2042c4e3d2e60 286 ProSitePatterns PS01242 Zinc finger FPG-type signature. 255 279 - T 09-03-2017 IPR015887 DNA glycosylase/AP lyase, zinc finger domain, DNA-binding site GO:0003677|GO:0003906|GO:0006281|GO:0008270|GO:0016799 TK78_RS08260 ffa14e63ba74a48079f2042c4e3d2e60 286 Pfam PF01149 Formamidopyrimidine-DNA glycosylase N-terminal domain 2 121 8.6E-32 T 09-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 TK78_RS08260 ffa14e63ba74a48079f2042c4e3d2e60 286 TIGRFAM TIGR00577 fpg: DNA-formamidopyrimidine glycosylase 1 279 1.1E-85 T 09-03-2017 IPR020629 Formamidopyrimidine-DNA glycosylase GO:0003906|GO:0006281|GO:0008270|GO:0008534 TK78_RS08260 ffa14e63ba74a48079f2042c4e3d2e60 286 SMART SM00898 2 123 5.1E-43 T 09-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 TK78_RS08260 ffa14e63ba74a48079f2042c4e3d2e60 286 SUPERFAMILY SSF46946 139 228 5.89E-25 T 09-03-2017 IPR010979 Ribosomal protein S13-like, H2TH GO:0003676 TK78_RS08260 ffa14e63ba74a48079f2042c4e3d2e60 286 Gene3D G3DSA:3.20.190.10 2 127 2.2E-35 T 09-03-2017 TK78_RS08260 ffa14e63ba74a48079f2042c4e3d2e60 286 Pfam PF06831 Formamidopyrimidine-DNA glycosylase H2TH domain 139 226 4.7E-20 T 09-03-2017 IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding GO:0003684|GO:0003906|GO:0006289|GO:0008270|GO:0016799 TK78_RS08260 ffa14e63ba74a48079f2042c4e3d2e60 286 Hamap MF_00103 Formamidopyrimidine-DNA glycosylase [mutM]. 1 280 40.256 T 09-03-2017 IPR020629 Formamidopyrimidine-DNA glycosylase GO:0003906|GO:0006281|GO:0008270|GO:0008534 TK78_RS08260 ffa14e63ba74a48079f2042c4e3d2e60 286 SUPERFAMILY SSF57716 231 280 3.87E-16 T 09-03-2017 TK78_RS08260 ffa14e63ba74a48079f2042c4e3d2e60 286 Pfam PF06827 Zinc finger found in FPG and IleRS 252 279 1.4E-6 T 09-03-2017 IPR010663 Zinc finger, FPG/IleRS-type Reactome: R-HSA-379726 TK78_RS08260 ffa14e63ba74a48079f2042c4e3d2e60 286 SUPERFAMILY SSF81624 2 144 8.77E-34 T 09-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 TK78_RS12140 9f9512e120dc097b8531406f68173539 238 Pfam PF03734 L,D-transpeptidase catalytic domain 122 231 1.6E-14 T 09-03-2017 IPR005490 L,D-transpeptidase catalytic domain GO:0016740 TK78_RS12140 9f9512e120dc097b8531406f68173539 238 Gene3D G3DSA:2.40.440.10 120 232 1.7E-12 T 09-03-2017 TK78_RS12140 9f9512e120dc097b8531406f68173539 238 SUPERFAMILY SSF47090 55 104 9.16E-7 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS12140 9f9512e120dc097b8531406f68173539 238 Pfam PF01471 Putative peptidoglycan binding domain 58 97 3.5E-5 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS12140 9f9512e120dc097b8531406f68173539 238 SUPERFAMILY SSF141523 121 232 2.49E-19 T 09-03-2017 TK78_RS12140 9f9512e120dc097b8531406f68173539 238 Gene3D G3DSA:1.10.101.10 59 103 9.4E-5 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS17145 0ef776a20f45b8aa88d5421c1e833ee1 374 PIRSF PIRSF001434 2 373 4.4E-106 T 09-03-2017 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 Reactome: R-HSA-1614558|Reactome: R-HSA-1614603|Reactome: R-HSA-2408508 TK78_RS17145 0ef776a20f45b8aa88d5421c1e833ee1 374 Gene3D G3DSA:3.40.640.10 7 247 2.4E-61 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS17145 0ef776a20f45b8aa88d5421c1e833ee1 374 Gene3D G3DSA:3.90.1150.10 248 371 8.8E-33 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS17145 0ef776a20f45b8aa88d5421c1e833ee1 374 Pfam PF01053 Cys/Met metabolism PLP-dependent enzyme 36 369 2.1E-82 T 09-03-2017 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 Reactome: R-HSA-1614558|Reactome: R-HSA-1614603|Reactome: R-HSA-2408508 TK78_RS17145 0ef776a20f45b8aa88d5421c1e833ee1 374 SUPERFAMILY SSF53383 40 371 1.85E-80 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS27115 420c3ca7aebba46cb0d9131dc8d25275 407 SUPERFAMILY SSF55307 201 315 6.18E-44 T 09-03-2017 IPR008280 Tubulin/FtsZ, C-terminal Reactome: R-HSA-380320 TK78_RS27115 420c3ca7aebba46cb0d9131dc8d25275 407 Gene3D G3DSA:3.30.1330.20 212 314 3.5E-49 T 09-03-2017 IPR018316 Tubulin/FtsZ, 2-layer sandwich domain Reactome: R-HSA-1445148|Reactome: R-HSA-190840|Reactome: R-HSA-190861|Reactome: R-HSA-2132295|Reactome: R-HSA-2467813|Reactome: R-HSA-2500257|Reactome: R-HSA-380320|Reactome: R-HSA-437239|Reactome: R-HSA-5617833|Reactome: R-HSA-5626467|Reactome: R-HSA-5663220|Reactome: R-HSA-6807878|Reactome: R-HSA-6811434|Reactome: R-HSA-6811436|Reactome: R-HSA-68877|Reactome: R-HSA-8852276|Reactome: R-HSA-983189 TK78_RS27115 420c3ca7aebba46cb0d9131dc8d25275 407 Hamap MF_00909 Cell division protein FtsZ [ftsZ]. 6 350 38.936 T 09-03-2017 IPR000158 Cell division protein FtsZ GO:0005525 TK78_RS27115 420c3ca7aebba46cb0d9131dc8d25275 407 Pfam PF00091 Tubulin/FtsZ family, GTPase domain 11 170 4.2E-38 T 09-03-2017 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 Reactome: R-HSA-380320 TK78_RS27115 420c3ca7aebba46cb0d9131dc8d25275 407 Pfam PF12327 FtsZ family, C-terminal domain 219 313 4.6E-35 T 09-03-2017 IPR024757 Cell division protein FtsZ, C-terminal TK78_RS27115 420c3ca7aebba46cb0d9131dc8d25275 407 SMART SM00864 10 202 2.8E-110 T 09-03-2017 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 Reactome: R-HSA-380320 TK78_RS27115 420c3ca7aebba46cb0d9131dc8d25275 407 SUPERFAMILY SSF52490 9 205 9.16E-68 T 09-03-2017 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 Reactome: R-HSA-380320 TK78_RS27115 420c3ca7aebba46cb0d9131dc8d25275 407 Gene3D G3DSA:3.40.50.1440 11 211 3.7E-92 T 09-03-2017 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 Reactome: R-HSA-380320 TK78_RS27115 420c3ca7aebba46cb0d9131dc8d25275 407 SMART SM00865 204 321 3.0E-57 T 09-03-2017 IPR018316 Tubulin/FtsZ, 2-layer sandwich domain Reactome: R-HSA-1445148|Reactome: R-HSA-190840|Reactome: R-HSA-190861|Reactome: R-HSA-2132295|Reactome: R-HSA-2467813|Reactome: R-HSA-2500257|Reactome: R-HSA-380320|Reactome: R-HSA-437239|Reactome: R-HSA-5617833|Reactome: R-HSA-5626467|Reactome: R-HSA-5663220|Reactome: R-HSA-6807878|Reactome: R-HSA-6811434|Reactome: R-HSA-6811436|Reactome: R-HSA-68877|Reactome: R-HSA-8852276|Reactome: R-HSA-983189 TK78_RS27115 420c3ca7aebba46cb0d9131dc8d25275 407 PRINTS PR00423 Cell division protein FtsZ signature 209 230 1.1E-51 T 09-03-2017 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 Reactome: R-HSA-380320 TK78_RS27115 420c3ca7aebba46cb0d9131dc8d25275 407 PRINTS PR00423 Cell division protein FtsZ signature 95 115 1.1E-51 T 09-03-2017 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 Reactome: R-HSA-380320 TK78_RS27115 420c3ca7aebba46cb0d9131dc8d25275 407 PRINTS PR00423 Cell division protein FtsZ signature 123 144 1.1E-51 T 09-03-2017 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 Reactome: R-HSA-380320 TK78_RS27115 420c3ca7aebba46cb0d9131dc8d25275 407 PRINTS PR00423 Cell division protein FtsZ signature 186 208 1.1E-51 T 09-03-2017 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 Reactome: R-HSA-380320 TK78_RS27115 420c3ca7aebba46cb0d9131dc8d25275 407 ProSitePatterns PS01134 FtsZ protein signature 1. 41 75 - T 09-03-2017 IPR020805 Cell division protein FtsZ, conserved site GO:0005525|GO:0005737 TK78_RS27115 420c3ca7aebba46cb0d9131dc8d25275 407 TIGRFAM TIGR00065 ftsZ: cell division protein FtsZ 7 323 8.2E-129 T 09-03-2017 IPR000158 Cell division protein FtsZ GO:0005525 TK78_RS27115 420c3ca7aebba46cb0d9131dc8d25275 407 ProSitePatterns PS01135 FtsZ protein signature 2. 94 115 - T 09-03-2017 IPR020805 Cell division protein FtsZ, conserved site GO:0005525|GO:0005737 TK78_RS02150 8baf7a208a6d171cdd61c677d5363f5d 320 SUPERFAMILY SSF53335 282 314 1.29E-14 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS02150 8baf7a208a6d171cdd61c677d5363f5d 320 SUPERFAMILY SSF53335 30 192 1.29E-14 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS02150 8baf7a208a6d171cdd61c677d5363f5d 320 Hamap MF_02037 Histidine N-alpha-methyltransferase [egtD]. 6 319 54.684 T 09-03-2017 IPR032888 Histidine N-alpha-methyltransferase, Actinobacteria-type GO:0008276|GO:0052699 KEGG: 00340+2.1.1.44|MetaCyc: PWY-7255|MetaCyc: PWY-7550 TK78_RS02150 8baf7a208a6d171cdd61c677d5363f5d 320 PIRSF PIRSF018005 4 320 1.9E-134 T 09-03-2017 IPR017804 Methyltransferase EgtD-like TK78_RS02150 8baf7a208a6d171cdd61c677d5363f5d 320 TIGRFAM TIGR03438 egtD_ergothio: dimethylhistidine N-methyltransferase 19 316 2.7E-115 T 09-03-2017 IPR017804 Methyltransferase EgtD-like TK78_RS02150 8baf7a208a6d171cdd61c677d5363f5d 320 Pfam PF10017 Histidine-specific methyltransferase, SAM-dependent 190 314 2.7E-41 T 09-03-2017 IPR019257 Histidine-specific methyltransferase, SAM-dependent TK78_RS02150 8baf7a208a6d171cdd61c677d5363f5d 320 Gene3D G3DSA:3.40.50.150 64 238 3.3E-8 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS02150 8baf7a208a6d171cdd61c677d5363f5d 320 Gene3D G3DSA:3.40.50.150 279 305 3.3E-8 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS09540 8d0f7cf6bf3a7bd87611863cae06ac78 320 Pfam PF03308 ArgK protein 21 282 1.4E-97 T 09-03-2017 TK78_RS09540 8d0f7cf6bf3a7bd87611863cae06ac78 320 Gene3D G3DSA:3.40.50.300 48 252 4.3E-50 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09540 8d0f7cf6bf3a7bd87611863cae06ac78 320 TIGRFAM TIGR00750 lao: LAO/AO transport system ATPase 16 313 9.0E-105 T 09-03-2017 IPR005129 SIMIBI class G3E GTPase, ArgK/MeaB GO:0003924|GO:0005525 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 TK78_RS09540 8d0f7cf6bf3a7bd87611863cae06ac78 320 SMART SM00382 47 297 0.0013 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS09540 8d0f7cf6bf3a7bd87611863cae06ac78 320 SUPERFAMILY SSF52540 5 312 3.37E-76 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS30380 76bead60eb5ed2717069a9677f5e896c 227 TIGRFAM TIGR01163 rpe: ribulose-phosphate 3-epimerase 4 211 1.9E-81 T 09-03-2017 IPR000056 Ribulose-phosphate 3-epimerase-like GO:0005975|GO:0016857 KEGG: 00030+5.1.3.1|KEGG: 00040+5.1.3.1|KEGG: 00710+5.1.3.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723 TK78_RS30380 76bead60eb5ed2717069a9677f5e896c 227 SUPERFAMILY SSF51366 2 212 2.0E-64 T 09-03-2017 IPR011060 Ribulose-phosphate binding barrel GO:0003824|GO:0008152 TK78_RS30380 76bead60eb5ed2717069a9677f5e896c 227 ProSitePatterns PS01086 Ribulose-phosphate 3-epimerase family signature 2. 131 153 - T 09-03-2017 IPR000056 Ribulose-phosphate 3-epimerase-like GO:0005975|GO:0016857 KEGG: 00030+5.1.3.1|KEGG: 00040+5.1.3.1|KEGG: 00710+5.1.3.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723 TK78_RS30380 76bead60eb5ed2717069a9677f5e896c 227 Pfam PF00834 Ribulose-phosphate 3 epimerase family 4 198 9.6E-79 T 09-03-2017 IPR000056 Ribulose-phosphate 3-epimerase-like GO:0005975|GO:0016857 KEGG: 00030+5.1.3.1|KEGG: 00040+5.1.3.1|KEGG: 00710+5.1.3.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723 TK78_RS30380 76bead60eb5ed2717069a9677f5e896c 227 PIRSF PIRSF001461 1 222 1.8E-95 T 09-03-2017 IPR026019 Ribulose-phosphate 3-epimerase GO:0004750|GO:0006098 KEGG: 00030+5.1.3.1|KEGG: 00040+5.1.3.1|KEGG: 00710+5.1.3.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723 TK78_RS30380 76bead60eb5ed2717069a9677f5e896c 227 ProSitePatterns PS01085 Ribulose-phosphate 3-epimerase family signature 1. 29 43 - T 09-03-2017 IPR000056 Ribulose-phosphate 3-epimerase-like GO:0005975|GO:0016857 KEGG: 00030+5.1.3.1|KEGG: 00040+5.1.3.1|KEGG: 00710+5.1.3.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723 TK78_RS30380 76bead60eb5ed2717069a9677f5e896c 227 Gene3D G3DSA:3.20.20.70 2 214 2.7E-90 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS27285 45322b7a9cdea2d920e05a85a746a339 316 SUPERFAMILY SSF53474 59 305 1.82E-45 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS27285 45322b7a9cdea2d920e05a85a746a339 316 Pfam PF01738 Dienelactone hydrolase family 110 237 2.1E-4 T 09-03-2017 IPR002925 Dienelactone hydrolase GO:0016787 TK78_RS27285 45322b7a9cdea2d920e05a85a746a339 316 Gene3D G3DSA:3.40.50.1820 59 306 4.3E-69 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS08670 10f20bbdee307f57e8b196056330a7a3 535 Pfam PF00682 HMGL-like 13 280 1.1E-44 T 09-03-2017 IPR000891 Pyruvate carboxyltransferase GO:0003824 TK78_RS08670 10f20bbdee307f57e8b196056330a7a3 535 SMART SM00917 383 526 1.8E-37 T 09-03-2017 IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 TK78_RS08670 10f20bbdee307f57e8b196056330a7a3 535 Pfam PF08502 LeuA allosteric (dimerisation) domain 383 524 1.2E-26 T 09-03-2017 IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 TK78_RS08670 10f20bbdee307f57e8b196056330a7a3 535 Gene3D G3DSA:3.20.20.70 5 356 4.8E-111 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS08670 10f20bbdee307f57e8b196056330a7a3 535 SUPERFAMILY SSF51569 8 300 1.25E-75 T 09-03-2017 TK78_RS08670 10f20bbdee307f57e8b196056330a7a3 535 SUPERFAMILY SSF110921 408 521 8.76E-22 T 09-03-2017 IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 TK78_RS08670 10f20bbdee307f57e8b196056330a7a3 535 ProSitePatterns PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1. 19 35 - T 09-03-2017 IPR002034 Alpha-isopropylmalate/homocitrate synthase, conserved site GO:0019752|GO:0046912 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 TK78_RS08670 10f20bbdee307f57e8b196056330a7a3 535 TIGRFAM TIGR00977 citramal_synth: citramalate synthase 12 529 2.2E-192 T 09-03-2017 IPR005675 Citramalate synthase GO:0019752|GO:0046912 KEGG: 00290+2.3.1.182|KEGG: 00660+2.3.1.182|MetaCyc: PWY-5101 TK78_RS08710 03538c0b647fd84e98babd60a09052bb 543 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 321 332 - T 09-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 TK78_RS08710 03538c0b647fd84e98babd60a09052bb 543 Pfam PF00171 Aldehyde dehydrogenase family 55 526 2.3E-100 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS08710 03538c0b647fd84e98babd60a09052bb 543 Gene3D G3DSA:3.40.309.10 303 501 6.0E-42 T 09-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 TK78_RS08710 03538c0b647fd84e98babd60a09052bb 543 TIGRFAM TIGR01236 D1pyr5carbox1: 1-pyrroline-5-carboxylate dehydrogenase 12 542 4.5E-241 T 09-03-2017 IPR005931 Delta-1-pyrroline-5-carboxylate dehydrogenase GO:0003842|GO:0006537|GO:0006561 KEGG: 00250+1.2.1.88|KEGG: 00330+1.2.1.88|MetaCyc: PWY-6853|Reactome: R-HSA-70688 TK78_RS08710 03538c0b647fd84e98babd60a09052bb 543 Gene3D G3DSA:3.40.605.10 41 302 2.4E-64 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS08710 03538c0b647fd84e98babd60a09052bb 543 SUPERFAMILY SSF53720 8 527 2.23E-122 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS21725 fcb2820f2e6f4a1c1582fbf9ac259a21 552 ProSitePatterns PS01233 Urocanase signature. 436 451 - T 09-03-2017 IPR023636 Urocanase conserved site GO:0016153 KEGG: 00340+4.2.1.49|MetaCyc: PWY-5028|MetaCyc: PWY-5030|Reactome: R-HSA-70921 TK78_RS21725 fcb2820f2e6f4a1c1582fbf9ac259a21 552 Pfam PF01175 Urocanase 7 540 3.9E-252 T 09-03-2017 IPR023637 Urocanase GO:0016153 KEGG: 00340+4.2.1.49|MetaCyc: PWY-5028|MetaCyc: PWY-5030|Reactome: R-HSA-70921 TK78_RS21725 fcb2820f2e6f4a1c1582fbf9ac259a21 552 Gene3D G3DSA:3.40.50.10730 137 343 2.7E-84 T 09-03-2017 TK78_RS21725 fcb2820f2e6f4a1c1582fbf9ac259a21 552 PIRSF PIRSF001423 1 552 1.4E-276 T 09-03-2017 IPR023637 Urocanase GO:0016153 KEGG: 00340+4.2.1.49|MetaCyc: PWY-5028|MetaCyc: PWY-5030|Reactome: R-HSA-70921 TK78_RS21725 fcb2820f2e6f4a1c1582fbf9ac259a21 552 Hamap MF_00577 Urocanate hydratase [hutU]. 2 550 49.043 T 09-03-2017 IPR023637 Urocanase GO:0016153 KEGG: 00340+4.2.1.49|MetaCyc: PWY-5028|MetaCyc: PWY-5030|Reactome: R-HSA-70921 TK78_RS21725 fcb2820f2e6f4a1c1582fbf9ac259a21 552 TIGRFAM TIGR01228 hutU: urocanate hydratase 6 548 2.5E-274 T 09-03-2017 IPR023637 Urocanase GO:0016153 KEGG: 00340+4.2.1.49|MetaCyc: PWY-5028|MetaCyc: PWY-5030|Reactome: R-HSA-70921 TK78_RS21725 fcb2820f2e6f4a1c1582fbf9ac259a21 552 SUPERFAMILY SSF111326 4 549 4.05E-247 T 09-03-2017 IPR023637 Urocanase GO:0016153 KEGG: 00340+4.2.1.49|MetaCyc: PWY-5028|MetaCyc: PWY-5030|Reactome: R-HSA-70921 TK78_RS21725 fcb2820f2e6f4a1c1582fbf9ac259a21 552 Gene3D G3DSA:3.40.1770.10 6 136 4.9E-151 T 09-03-2017 TK78_RS21725 fcb2820f2e6f4a1c1582fbf9ac259a21 552 Gene3D G3DSA:3.40.1770.10 354 549 4.9E-151 T 09-03-2017 TK78_RS22990 11dc5ea9123db55f788249c3ed3e5051 351 Gene3D G3DSA:3.40.190.10 278 311 1.3E-36 T 09-03-2017 TK78_RS22990 11dc5ea9123db55f788249c3ed3e5051 351 Gene3D G3DSA:3.40.190.10 6 134 1.3E-36 T 09-03-2017 TK78_RS22990 11dc5ea9123db55f788249c3ed3e5051 351 SUPERFAMILY SSF53850 31 346 4.53E-56 T 09-03-2017 TK78_RS22990 11dc5ea9123db55f788249c3ed3e5051 351 Pfam PF13343 Bacterial extracellular solute-binding protein 88 334 1.1E-28 T 09-03-2017 TK78_RS22990 11dc5ea9123db55f788249c3ed3e5051 351 Gene3D G3DSA:3.40.190.10 138 277 3.7E-27 T 09-03-2017 TK78_RS22990 11dc5ea9123db55f788249c3ed3e5051 351 PIRSF PIRSF002825 5 349 4.6E-48 T 09-03-2017 IPR026045 Ferric binding protein TK78_RS22585 a635a302b1453a762db97f97d659ddd6 105 Gene3D G3DSA:3.30.1390.10 16 103 4.0E-28 T 09-03-2017 IPR014719 Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like TK78_RS22585 a635a302b1453a762db97f97d659ddd6 105 Hamap MF_00302 ATP-dependent Clp protease adapter protein ClpS [clpS]. 13 104 16.863 T 09-03-2017 IPR022935 ATP-dependent Clp protease adaptor protein ClpS TK78_RS22585 a635a302b1453a762db97f97d659ddd6 105 SUPERFAMILY SSF54736 26 100 3.5E-24 T 09-03-2017 IPR014719 Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like TK78_RS22585 a635a302b1453a762db97f97d659ddd6 105 Pfam PF02617 ATP-dependent Clp protease adaptor protein ClpS 29 98 2.3E-21 T 09-03-2017 IPR003769 Adaptor protein ClpS, core GO:0030163 Reactome: R-HSA-983168 TK78_RS12705 049d044bbb01a73a79d68489022fed8c 374 SUPERFAMILY SSF51412 12 77 1.98E-68 T 09-03-2017 TK78_RS12705 049d044bbb01a73a79d68489022fed8c 374 SUPERFAMILY SSF51412 113 369 1.98E-68 T 09-03-2017 TK78_RS12705 049d044bbb01a73a79d68489022fed8c 374 SMART SM01240 14 373 7.7E-28 T 09-03-2017 TK78_RS12705 049d044bbb01a73a79d68489022fed8c 374 Pfam PF00478 IMP dehydrogenase / GMP reductase domain 15 297 5.9E-43 T 09-03-2017 IPR001093 IMP dehydrogenase/GMP reductase GO:0003824|GO:0055114 TK78_RS12705 049d044bbb01a73a79d68489022fed8c 374 TIGRFAM TIGR01304 IMP_DH_rel_2: IMP dehydrogenase family protein 4 367 6.3E-192 T 09-03-2017 IPR005992 IMP dehydrogenase-related 2 GO:0016491|GO:0055114 TK78_RS12705 049d044bbb01a73a79d68489022fed8c 374 Gene3D G3DSA:3.20.20.70 13 367 1.8E-73 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS08135 7f5117b976e4c9e3b73b6d88817d58aa 298 SUPERFAMILY SSF51306 71 119 4.29E-46 T 09-03-2017 IPR015927 Peptidase S24/S26A/S26B/S26C TK78_RS08135 7f5117b976e4c9e3b73b6d88817d58aa 298 SUPERFAMILY SSF51306 146 253 4.29E-46 T 09-03-2017 IPR015927 Peptidase S24/S26A/S26B/S26C TK78_RS08135 7f5117b976e4c9e3b73b6d88817d58aa 298 Pfam PF10502 Signal peptidase, peptidase S26 128 243 5.0E-10 T 09-03-2017 IPR019533 Peptidase S26 TK78_RS08135 7f5117b976e4c9e3b73b6d88817d58aa 298 TIGRFAM TIGR02227 sigpep_I_bact: signal peptidase I 58 247 7.2E-41 T 09-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 TK78_RS08135 7f5117b976e4c9e3b73b6d88817d58aa 298 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 151 163 1.3E-20 T 09-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 TK78_RS08135 7f5117b976e4c9e3b73b6d88817d58aa 298 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 72 88 1.3E-20 T 09-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 TK78_RS08135 7f5117b976e4c9e3b73b6d88817d58aa 298 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 201 220 1.3E-20 T 09-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 TK78_RS08135 7f5117b976e4c9e3b73b6d88817d58aa 298 ProSitePatterns PS00761 Signal peptidases I signature 3. 206 219 - T 09-03-2017 IPR019758 Peptidase S26A, signal peptidase I, conserved site GO:0008236|GO:0016021 TK78_RS08135 7f5117b976e4c9e3b73b6d88817d58aa 298 Gene3D G3DSA:2.10.109.10 68 161 1.5E-39 T 09-03-2017 IPR028360 Peptidase S24/S26, beta-ribbon domain TK78_RS08135 7f5117b976e4c9e3b73b6d88817d58aa 298 Gene3D G3DSA:2.10.109.10 201 253 1.5E-39 T 09-03-2017 IPR028360 Peptidase S24/S26, beta-ribbon domain TK78_RS08135 7f5117b976e4c9e3b73b6d88817d58aa 298 Pfam PF00717 Peptidase S24-like 79 123 9.4E-12 T 09-03-2017 IPR019759 Peptidase S24/S26A/S26B TK78_RS01185 8ecce8ad5efb111765d65dfa6bdbf877 299 SUPERFAMILY SSF51679 32 296 9.59E-30 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS01185 8ecce8ad5efb111765d65dfa6bdbf877 299 Gene3D G3DSA:3.20.20.30 146 285 1.6E-10 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS01185 8ecce8ad5efb111765d65dfa6bdbf877 299 Gene3D G3DSA:3.20.20.30 32 134 2.1E-8 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS01185 8ecce8ad5efb111765d65dfa6bdbf877 299 TIGRFAM TIGR03620 F420_MSMEG_4141: probable F420-dependent oxidoreductase, MSMEG_4141 family 13 294 8.4E-103 T 09-03-2017 IPR019922 Luciferase-like, F420-dependent oxidoreductase, MSMEG4141, predicted TK78_RS01185 8ecce8ad5efb111765d65dfa6bdbf877 299 Pfam PF00296 Luciferase-like monooxygenase 20 134 1.9E-7 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS15335 3be18248ca887995777a2d2ea68a8b6a 173 Pfam PF07811 TadE-like protein 62 104 8.5E-6 T 09-03-2017 IPR012495 TadE-like TK78_RS01745 113fe5b52735548230115f969a105c3c 54 Pfam PF00471 Ribosomal protein L33 9 53 1.8E-15 T 09-03-2017 IPR001705 Ribosomal protein L33 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS01745 113fe5b52735548230115f969a105c3c 54 TIGRFAM TIGR01023 rpmG_bact: ribosomal protein bL33 1 54 6.4E-22 T 09-03-2017 IPR001705 Ribosomal protein L33 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS01745 113fe5b52735548230115f969a105c3c 54 SUPERFAMILY SSF57829 4 54 1.4E-16 T 09-03-2017 IPR011332 Zinc-binding ribosomal protein GO:0006412 TK78_RS01745 113fe5b52735548230115f969a105c3c 54 ProSitePatterns PS00582 Ribosomal protein L33 signature. 22 41 - T 09-03-2017 IPR018264 Ribosomal protein L33, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS01745 113fe5b52735548230115f969a105c3c 54 Hamap MF_00294 50S ribosomal protein L33 [rpmG]. 2 54 14.097 T 09-03-2017 IPR001705 Ribosomal protein L33 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS03860 3ca3b273e850d8d5050edb39e14682e3 68 Gene3D G3DSA:3.40.50.300 1 54 1.3E-7 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03860 3ca3b273e850d8d5050edb39e14682e3 68 SUPERFAMILY SSF52540 1 53 1.15E-6 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10600 ca57f10d350a491cc0794f2af98f79a0 465 SUPERFAMILY SSF53187 375 460 1.6E-66 T 09-03-2017 TK78_RS10600 ca57f10d350a491cc0794f2af98f79a0 465 SUPERFAMILY SSF53187 9 204 1.6E-66 T 09-03-2017 TK78_RS10600 ca57f10d350a491cc0794f2af98f79a0 465 Pfam PF07687 Peptidase dimerisation domain 201 360 1.1E-23 T 09-03-2017 IPR011650 Peptidase M20, dimerisation domain TK78_RS10600 ca57f10d350a491cc0794f2af98f79a0 465 Gene3D G3DSA:3.30.70.360 204 364 2.1E-56 T 09-03-2017 IPR011650 Peptidase M20, dimerisation domain TK78_RS10600 ca57f10d350a491cc0794f2af98f79a0 465 Pfam PF01546 Peptidase family M20/M25/M40 88 456 7.4E-36 T 09-03-2017 IPR002933 Peptidase M20 GO:0008152|GO:0016787 TK78_RS10600 ca57f10d350a491cc0794f2af98f79a0 465 Gene3D G3DSA:3.40.630.10 9 198 1.8E-68 T 09-03-2017 TK78_RS10600 ca57f10d350a491cc0794f2af98f79a0 465 Gene3D G3DSA:3.40.630.10 374 460 1.8E-68 T 09-03-2017 TK78_RS28625 cd5ca55794a092c8cb18d1ef7ec719d0 600 Pfam PF00723 Glycosyl hydrolases family 15 220 589 1.0E-75 T 09-03-2017 IPR011613 Glycoside hydrolase family 15/Phosphorylase b kinase regulatory chain family Reactome: R-HSA-70221 TK78_RS28625 cd5ca55794a092c8cb18d1ef7ec719d0 600 Gene3D G3DSA:1.50.10.10 216 593 3.6E-85 T 09-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 TK78_RS28625 cd5ca55794a092c8cb18d1ef7ec719d0 600 SUPERFAMILY SSF48208 194 593 1.17E-112 T 09-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 TK78_RS07430 15344806fcd88d2c1c8ddb4ae701cb70 506 Gene3D G3DSA:3.80.30.20 159 390 6.1E-84 T 09-03-2017 IPR023404 Radical SAM, alpha/beta horseshoe TK78_RS07430 15344806fcd88d2c1c8ddb4ae701cb70 506 TIGRFAM TIGR01574 miaB-methiolase: tRNA-i(6)A37 thiotransferase enzyme MiaB 16 452 1.2E-146 T 09-03-2017 TK78_RS07430 15344806fcd88d2c1c8ddb4ae701cb70 506 Pfam PF04055 Radical SAM superfamily 163 333 3.7E-29 T 09-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 TK78_RS07430 15344806fcd88d2c1c8ddb4ae701cb70 506 Hamap MF_01864 tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase [miaB]. 14 456 67.484 T 09-03-2017 IPR006463 tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase MiaB GO:0005737|GO:0006400|GO:0016740|GO:0051539 TK78_RS07430 15344806fcd88d2c1c8ddb4ae701cb70 506 SUPERFAMILY SSF102114 146 384 5.36E-58 T 09-03-2017 TK78_RS07430 15344806fcd88d2c1c8ddb4ae701cb70 506 ProSitePatterns PS01278 Methylthiotransferase radical SAM domain signature. 163 183 - T 09-03-2017 IPR020612 Methylthiotransferase, conserved site GO:0051539 TK78_RS07430 15344806fcd88d2c1c8ddb4ae701cb70 506 SMART SM00729 159 374 5.2E-59 T 09-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 TK78_RS07430 15344806fcd88d2c1c8ddb4ae701cb70 506 Pfam PF00919 Uncharacterized protein family UPF0004 17 116 1.3E-26 T 09-03-2017 IPR013848 Methylthiotransferase, N-terminal GO:0003824|GO:0009451|GO:0051539 TK78_RS07430 15344806fcd88d2c1c8ddb4ae701cb70 506 TIGRFAM TIGR00089 TIGR00089: radical SAM methylthiotransferase, MiaB/RimO family 16 451 1.0E-152 T 09-03-2017 IPR005839 Methylthiotransferase GO:0016740|GO:0043412|GO:0051539 TK78_RS03030 7b154a67a98ef3fd74d8fdf011105602 142 SUPERFAMILY SSF50475 3 139 1.35E-20 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS03030 7b154a67a98ef3fd74d8fdf011105602 142 Gene3D G3DSA:2.30.110.10 4 137 4.1E-21 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS03030 7b154a67a98ef3fd74d8fdf011105602 142 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 6 86 9.9E-8 T 09-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS17000 e267bf8ac8d0af982feae85b3c088aa2 425 TIGRFAM TIGR00414 serS: serine--tRNA ligase 2 414 1.3E-131 T 09-03-2017 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 TK78_RS17000 e267bf8ac8d0af982feae85b3c088aa2 425 Hamap MF_00176 Serine--tRNA ligase [serS]. 1 419 38.843 T 09-03-2017 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 TK78_RS17000 e267bf8ac8d0af982feae85b3c088aa2 425 Pfam PF02403 Seryl-tRNA synthetase N-terminal domain 1 106 3.3E-22 T 09-03-2017 IPR015866 Serine-tRNA synthetase, type1, N-terminal KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 TK78_RS17000 e267bf8ac8d0af982feae85b3c088aa2 425 SUPERFAMILY SSF55681 132 417 7.61E-85 T 09-03-2017 TK78_RS17000 e267bf8ac8d0af982feae85b3c088aa2 425 PIRSF PIRSF001529 1 423 3.4E-139 T 09-03-2017 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 TK78_RS17000 e267bf8ac8d0af982feae85b3c088aa2 425 SUPERFAMILY SSF46589 2 111 9.42E-23 T 09-03-2017 IPR010978 tRNA-binding arm GO:0000166 TK78_RS17000 e267bf8ac8d0af982feae85b3c088aa2 425 Pfam PF00587 tRNA synthetase class II core domain (G, H, P, S and T) 221 397 3.3E-29 T 09-03-2017 IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS17000 e267bf8ac8d0af982feae85b3c088aa2 425 PRINTS PR00981 Seryl-tRNA synthetase signature 263 275 1.4E-29 T 09-03-2017 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 TK78_RS17000 e267bf8ac8d0af982feae85b3c088aa2 425 PRINTS PR00981 Seryl-tRNA synthetase signature 275 288 1.4E-29 T 09-03-2017 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 TK78_RS17000 e267bf8ac8d0af982feae85b3c088aa2 425 PRINTS PR00981 Seryl-tRNA synthetase signature 315 328 1.4E-29 T 09-03-2017 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 TK78_RS17000 e267bf8ac8d0af982feae85b3c088aa2 425 PRINTS PR00981 Seryl-tRNA synthetase signature 332 348 1.4E-29 T 09-03-2017 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 TK78_RS17000 e267bf8ac8d0af982feae85b3c088aa2 425 PRINTS PR00981 Seryl-tRNA synthetase signature 350 366 1.4E-29 T 09-03-2017 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 TK78_RS17000 e267bf8ac8d0af982feae85b3c088aa2 425 Gene3D G3DSA:1.10.287.40 2 102 4.5E-26 T 09-03-2017 IPR015866 Serine-tRNA synthetase, type1, N-terminal KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 TK78_RS17000 e267bf8ac8d0af982feae85b3c088aa2 425 Gene3D G3DSA:3.30.930.10 104 418 8.8E-124 T 09-03-2017 TK78_RS06260 575097f6040676c0530ee8d4bd25b982 872 Gene3D G3DSA:3.30.450.40 383 492 1.6E-12 T 09-03-2017 IPR029016 GAF domain-like TK78_RS06260 575097f6040676c0530ee8d4bd25b982 872 Gene3D G3DSA:3.30.450.40 296 347 1.6E-12 T 09-03-2017 IPR029016 GAF domain-like TK78_RS06260 575097f6040676c0530ee8d4bd25b982 872 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 542 740 4.4E-52 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS06260 575097f6040676c0530ee8d4bd25b982 872 SUPERFAMILY SSF81606 529 739 2.88E-5 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS06260 575097f6040676c0530ee8d4bd25b982 872 SMART SM00091 10 79 0.0032 T 09-03-2017 IPR000014 PAS domain TK78_RS06260 575097f6040676c0530ee8d4bd25b982 872 SMART SM00091 162 226 9.4 T 09-03-2017 IPR000014 PAS domain TK78_RS06260 575097f6040676c0530ee8d4bd25b982 872 Pfam PF08448 PAS fold 169 287 1.4E-14 T 09-03-2017 IPR013656 PAS fold-4 TK78_RS06260 575097f6040676c0530ee8d4bd25b982 872 SUPERFAMILY SSF55781 427 495 3.92E-5 T 09-03-2017 IPR029016 GAF domain-like TK78_RS06260 575097f6040676c0530ee8d4bd25b982 872 SUPERFAMILY SSF55874 781 858 1.74E-7 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS06260 575097f6040676c0530ee8d4bd25b982 872 SUPERFAMILY SSF55785 153 278 1.74E-11 T 09-03-2017 IPR000014 PAS domain TK78_RS06260 575097f6040676c0530ee8d4bd25b982 872 Gene3D G3DSA:3.30.450.20 158 285 2.1E-13 T 09-03-2017 TK78_RS06260 575097f6040676c0530ee8d4bd25b982 872 Gene3D G3DSA:3.30.450.20 7 76 3.3E-7 T 09-03-2017 TK78_RS06260 575097f6040676c0530ee8d4bd25b982 872 SMART SM00331 515 740 1.8E-31 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS06260 575097f6040676c0530ee8d4bd25b982 872 SUPERFAMILY SSF55785 10 64 4.03E-7 T 09-03-2017 IPR000014 PAS domain TK78_RS06260 575097f6040676c0530ee8d4bd25b982 872 Pfam PF13581 Histidine kinase-like ATPase domain 754 861 4.6E-10 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS28270 a7bd8143327e9aacf3d8c9cc27b06257 137 SUPERFAMILY SSF54593 14 131 4.97E-22 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS28270 a7bd8143327e9aacf3d8c9cc27b06257 137 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 14 128 3.5E-6 T 09-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain TK78_RS28270 a7bd8143327e9aacf3d8c9cc27b06257 137 Gene3D G3DSA:3.10.180.10 9 131 1.5E-25 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS12420 6149b871edd95c9ef5def24cd8d48160 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 84 95 4.7E-15 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS12420 6149b871edd95c9ef5def24cd8d48160 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 157 176 4.7E-15 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS12420 6149b871edd95c9ef5def24cd8d48160 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 10 27 4.7E-15 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS12420 6149b871edd95c9ef5def24cd8d48160 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 131 147 4.7E-15 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS12420 6149b871edd95c9ef5def24cd8d48160 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 178 195 4.7E-15 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS12420 6149b871edd95c9ef5def24cd8d48160 251 Gene3D G3DSA:3.40.50.720 12 240 5.2E-37 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS12420 6149b871edd95c9ef5def24cd8d48160 251 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 144 172 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS12420 6149b871edd95c9ef5def24cd8d48160 251 Pfam PF00106 short chain dehydrogenase 11 200 2.3E-26 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS12420 6149b871edd95c9ef5def24cd8d48160 251 SUPERFAMILY SSF51735 11 247 5.98E-39 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS00445 ef33de22a39add36c009ff2494e5c4e0 396 SUPERFAMILY SSF51905 1 294 7.89E-28 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS00445 ef33de22a39add36c009ff2494e5c4e0 396 Gene3D G3DSA:3.50.50.60 1 107 1.9E-21 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS00445 ef33de22a39add36c009ff2494e5c4e0 396 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 4 294 4.4E-42 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS00445 ef33de22a39add36c009ff2494e5c4e0 396 Gene3D G3DSA:3.50.50.60 108 294 2.2E-30 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS00445 ef33de22a39add36c009ff2494e5c4e0 396 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 100 118 3.9E-14 T 09-03-2017 TK78_RS00445 ef33de22a39add36c009ff2494e5c4e0 396 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 5 24 3.9E-14 T 09-03-2017 TK78_RS00445 ef33de22a39add36c009ff2494e5c4e0 396 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 147 165 3.9E-14 T 09-03-2017 TK78_RS00445 ef33de22a39add36c009ff2494e5c4e0 396 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 255 277 3.9E-14 T 09-03-2017 TK78_RS00445 ef33de22a39add36c009ff2494e5c4e0 396 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 101 109 1.2E-7 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS00445 ef33de22a39add36c009ff2494e5c4e0 396 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 143 167 1.2E-7 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS00445 ef33de22a39add36c009ff2494e5c4e0 396 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 4 26 1.2E-7 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS00445 ef33de22a39add36c009ff2494e5c4e0 396 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 265 283 1.2E-7 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS26355 9716b4b8a9d954221b18cb1a6f8f6e48 347 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 4 14 9.1E-5 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS26355 9716b4b8a9d954221b18cb1a6f8f6e48 347 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 14 24 9.1E-5 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS26355 9716b4b8a9d954221b18cb1a6f8f6e48 347 SUPERFAMILY SSF47413 3 49 6.75E-12 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS26355 9716b4b8a9d954221b18cb1a6f8f6e48 347 SMART SM00354 2 69 2.3E-24 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS26355 9716b4b8a9d954221b18cb1a6f8f6e48 347 ProSitePatterns PS00356 LacI-type HTH domain signature. 5 23 - T 09-03-2017 TK78_RS26355 9716b4b8a9d954221b18cb1a6f8f6e48 347 SUPERFAMILY SSF53822 59 337 1.47E-65 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS26355 9716b4b8a9d954221b18cb1a6f8f6e48 347 Gene3D G3DSA:3.40.50.2300 171 334 2.8E-51 T 09-03-2017 TK78_RS26355 9716b4b8a9d954221b18cb1a6f8f6e48 347 Gene3D G3DSA:1.10.260.40 3 47 3.0E-18 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS26355 9716b4b8a9d954221b18cb1a6f8f6e48 347 Pfam PF13377 Periplasmic binding protein-like domain 171 333 2.0E-35 T 09-03-2017 TK78_RS26355 9716b4b8a9d954221b18cb1a6f8f6e48 347 Gene3D G3DSA:3.40.50.2300 58 170 4.0E-26 T 09-03-2017 TK78_RS26355 9716b4b8a9d954221b18cb1a6f8f6e48 347 Pfam PF00356 Bacterial regulatory proteins, lacI family 5 47 3.5E-15 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS08185 b632e149947bd27aaa8454e504fed259 517 Gene3D G3DSA:1.10.260.30 334 435 2.5E-37 T 09-03-2017 IPR004125 Signal recognition particle, SRP54 subunit, M-domain GO:0006614|GO:0008312|GO:0048500 Reactome: R-HSA-1799339 TK78_RS08185 b632e149947bd27aaa8454e504fed259 517 SMART SM00962 100 298 6.5E-106 T 09-03-2017 IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain GO:0005525|GO:0006614 Reactome: R-HSA-1799339 TK78_RS08185 b632e149947bd27aaa8454e504fed259 517 Gene3D G3DSA:1.20.120.140 2 89 8.4E-35 T 09-03-2017 TK78_RS08185 b632e149947bd27aaa8454e504fed259 517 Pfam PF02978 Signal peptide binding domain 334 431 1.2E-30 T 09-03-2017 IPR004125 Signal recognition particle, SRP54 subunit, M-domain GO:0006614|GO:0008312|GO:0048500 Reactome: R-HSA-1799339 TK78_RS08185 b632e149947bd27aaa8454e504fed259 517 Hamap MF_00306 Signal recognition particle 54 kDa protein [srp54]. 5 450 32.595 T 09-03-2017 IPR022941 Signal recognition particle, SRP54 subunit GO:0003924|GO:0005525|GO:0006614|GO:0048500 Reactome: R-HSA-1799339 TK78_RS08185 b632e149947bd27aaa8454e504fed259 517 SMART SM00382 99 303 4.6E-12 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS08185 b632e149947bd27aaa8454e504fed259 517 SMART SM00963 1 86 2.3E-35 T 09-03-2017 IPR013822 Signal recognition particle, SRP54 subunit, helical bundle GO:0005525|GO:0006614 Reactome: R-HSA-1799339 TK78_RS08185 b632e149947bd27aaa8454e504fed259 517 SUPERFAMILY SSF47446 300 434 7.06E-42 T 09-03-2017 IPR004125 Signal recognition particle, SRP54 subunit, M-domain GO:0006614|GO:0008312|GO:0048500 Reactome: R-HSA-1799339 TK78_RS08185 b632e149947bd27aaa8454e504fed259 517 SUPERFAMILY SSF52540 42 360 4.09E-57 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08185 b632e149947bd27aaa8454e504fed259 517 Pfam PF00448 SRP54-type protein, GTPase domain 100 297 1.9E-68 T 09-03-2017 IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain GO:0005525|GO:0006614 Reactome: R-HSA-1799339 TK78_RS08185 b632e149947bd27aaa8454e504fed259 517 TIGRFAM TIGR00959 ffh: signal recognition particle protein 2 433 1.1E-169 T 09-03-2017 IPR004780 Signal recognition particle protein Ffh GO:0003924|GO:0005525|GO:0006614|GO:0048500 TK78_RS08185 b632e149947bd27aaa8454e504fed259 517 Pfam PF02881 SRP54-type protein, helical bundle domain 5 82 3.0E-21 T 09-03-2017 IPR013822 Signal recognition particle, SRP54 subunit, helical bundle GO:0005525|GO:0006614 Reactome: R-HSA-1799339 TK78_RS08185 b632e149947bd27aaa8454e504fed259 517 Gene3D G3DSA:3.40.50.300 95 299 3.4E-71 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS04730 de4014af205bd82a954acfe7f4277a8a 549 Pfam PF03023 MviN-like protein 44 499 1.0E-98 T 09-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ TK78_RS04730 de4014af205bd82a954acfe7f4277a8a 549 TIGRFAM TIGR01695 murJ_mviN: murein biosynthesis integral membrane protein MurJ 17 509 2.1E-103 T 09-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ TK78_RS04730 de4014af205bd82a954acfe7f4277a8a 549 PRINTS PR01806 Virulence factor MviN signature 48 67 8.4E-22 T 09-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ TK78_RS04730 de4014af205bd82a954acfe7f4277a8a 549 PRINTS PR01806 Virulence factor MviN signature 288 314 8.4E-22 T 09-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ TK78_RS04730 de4014af205bd82a954acfe7f4277a8a 549 PRINTS PR01806 Virulence factor MviN signature 386 405 8.4E-22 T 09-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ TK78_RS04730 de4014af205bd82a954acfe7f4277a8a 549 PRINTS PR01806 Virulence factor MviN signature 168 189 8.4E-22 T 09-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ TK78_RS04730 de4014af205bd82a954acfe7f4277a8a 549 PRINTS PR01806 Virulence factor MviN signature 67 83 8.4E-22 T 09-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ TK78_RS04730 de4014af205bd82a954acfe7f4277a8a 549 PRINTS PR01806 Virulence factor MviN signature 144 168 8.4E-22 T 09-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ TK78_RS11465 ffa398cfad9b63a149c83b33c6ff5215 323 SMART SM00244 91 255 5.6E-6 T 09-03-2017 IPR001107 Band 7 domain TK78_RS11465 ffa398cfad9b63a149c83b33c6ff5215 323 SUPERFAMILY SSF117892 128 257 1.12E-6 T 09-03-2017 IPR001107 Band 7 domain TK78_RS11465 ffa398cfad9b63a149c83b33c6ff5215 323 Pfam PF01145 SPFH domain / Band 7 family 95 268 1.9E-22 T 09-03-2017 IPR001107 Band 7 domain TK78_RS21600 32fcde3ebf1448c02310ff0f7510bef8 439 Gene3D G3DSA:3.40.50.150 137 410 2.8E-93 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS21600 32fcde3ebf1448c02310ff0f7510bef8 439 PIRSF PIRSF003085 4 430 4.5E-133 T 09-03-2017 IPR003333 Mycolic acid cyclopropane synthase GO:0008610 TK78_RS21600 32fcde3ebf1448c02310ff0f7510bef8 439 Pfam PF02353 Mycolic acid cyclopropane synthetase 138 408 7.7E-94 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS21600 32fcde3ebf1448c02310ff0f7510bef8 439 SUPERFAMILY SSF53335 147 414 2.61E-77 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS21600 32fcde3ebf1448c02310ff0f7510bef8 439 SMART SM00828 Methyltransferase in polyketide synthase (PKS) enzymes. 156 396 0.0035 T 09-03-2017 IPR020803 Polyketide synthase, methyltransferase domain TK78_RS30610 fd57bd552f33bf45ca26d33095e637b5 130 Gene3D G3DSA:1.25.40.20 14 120 4.6E-20 T 09-03-2017 IPR020683 Ankyrin repeat-containing domain TK78_RS30610 fd57bd552f33bf45ca26d33095e637b5 130 Pfam PF12796 Ankyrin repeats (3 copies) 22 105 2.8E-9 T 09-03-2017 IPR020683 Ankyrin repeat-containing domain TK78_RS30610 fd57bd552f33bf45ca26d33095e637b5 130 SUPERFAMILY SSF48403 17 126 3.58E-19 T 09-03-2017 IPR020683 Ankyrin repeat-containing domain TK78_RS30610 fd57bd552f33bf45ca26d33095e637b5 130 SMART SM00248 44 73 0.0054 T 09-03-2017 IPR002110 Ankyrin repeat GO:0005515 TK78_RS30610 fd57bd552f33bf45ca26d33095e637b5 130 SMART SM00248 77 106 2.7 T 09-03-2017 IPR002110 Ankyrin repeat GO:0005515 TK78_RS23270 ccc7c94c639c445a7b165f67548dc176 559 Gene3D G3DSA:3.50.50.60 293 374 5.5E-50 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS23270 ccc7c94c639c445a7b165f67548dc176 559 Gene3D G3DSA:3.50.50.60 116 199 5.5E-50 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS23270 ccc7c94c639c445a7b165f67548dc176 559 Gene3D G3DSA:3.50.50.60 7 72 5.5E-50 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS23270 ccc7c94c639c445a7b165f67548dc176 559 Pfam PF01494 FAD binding domain 7 368 1.0E-71 T 09-03-2017 IPR002938 FAD-binding domain GO:0071949 TK78_RS23270 ccc7c94c639c445a7b165f67548dc176 559 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 338 356 1.2E-42 T 09-03-2017 TK78_RS23270 ccc7c94c639c445a7b165f67548dc176 559 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 305 320 1.2E-42 T 09-03-2017 TK78_RS23270 ccc7c94c639c445a7b165f67548dc176 559 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 320 336 1.2E-42 T 09-03-2017 TK78_RS23270 ccc7c94c639c445a7b165f67548dc176 559 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 356 372 1.2E-42 T 09-03-2017 TK78_RS23270 ccc7c94c639c445a7b165f67548dc176 559 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 173 188 1.2E-42 T 09-03-2017 TK78_RS23270 ccc7c94c639c445a7b165f67548dc176 559 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 8 30 1.2E-42 T 09-03-2017 TK78_RS23270 ccc7c94c639c445a7b165f67548dc176 559 SUPERFAMILY SSF51905 7 194 2.76E-54 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS23270 ccc7c94c639c445a7b165f67548dc176 559 SUPERFAMILY SSF51905 292 379 2.76E-54 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS23780 b776ed377f0884a1c48be9f8869aa827 1014 SUPERFAMILY SSF158745 658 1009 1.19E-41 T 09-03-2017 TK78_RS23780 b776ed377f0884a1c48be9f8869aa827 1014 PIRSF PIRSF037228 75 1012 4.0E-149 T 09-03-2017 IPR017146 Type 2 lantibiotic biosynthesis protein LanM TK78_RS23780 b776ed377f0884a1c48be9f8869aa827 1014 TIGRFAM TIGR03897 lanti_2_LanM: type 2 lantibiotic biosynthesis protein LanM 82 996 8.0E-208 T 09-03-2017 IPR017146 Type 2 lantibiotic biosynthesis protein LanM TK78_RS23780 b776ed377f0884a1c48be9f8869aa827 1014 SMART SM01260 681 1007 4.7E-47 T 09-03-2017 IPR007822 Lanthionine synthetase C-like TK78_RS23780 b776ed377f0884a1c48be9f8869aa827 1014 PRINTS PR01950 LanC-like protein superfamily signature 979 996 2.5E-5 T 09-03-2017 IPR007822 Lanthionine synthetase C-like TK78_RS23780 b776ed377f0884a1c48be9f8869aa827 1014 PRINTS PR01950 LanC-like protein superfamily signature 924 937 2.5E-5 T 09-03-2017 IPR007822 Lanthionine synthetase C-like TK78_RS23780 b776ed377f0884a1c48be9f8869aa827 1014 PRINTS PR01950 LanC-like protein superfamily signature 878 898 2.5E-5 T 09-03-2017 IPR007822 Lanthionine synthetase C-like TK78_RS23780 b776ed377f0884a1c48be9f8869aa827 1014 PRINTS PR01950 LanC-like protein superfamily signature 739 757 2.5E-5 T 09-03-2017 IPR007822 Lanthionine synthetase C-like TK78_RS23780 b776ed377f0884a1c48be9f8869aa827 1014 Pfam PF13575 Domain of unknown function (DUF4135) 172 556 6.1E-127 T 09-03-2017 IPR025410 Domain of unknown function DUF4135 TK78_RS23780 b776ed377f0884a1c48be9f8869aa827 1014 Pfam PF05147 Lanthionine synthetase C-like protein 682 997 3.7E-25 T 09-03-2017 IPR007822 Lanthionine synthetase C-like TK78_RS18850 9281bcb6d0e96c3f89fd7061f123ed6c 279 Pfam PF00581 Rhodanese-like domain 10 118 1.1E-16 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS18850 9281bcb6d0e96c3f89fd7061f123ed6c 279 Pfam PF00581 Rhodanese-like domain 149 266 2.4E-15 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS18850 9281bcb6d0e96c3f89fd7061f123ed6c 279 SUPERFAMILY SSF52821 149 276 4.85E-33 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS18850 9281bcb6d0e96c3f89fd7061f123ed6c 279 Gene3D G3DSA:3.40.250.10 4 140 3.1E-37 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS18850 9281bcb6d0e96c3f89fd7061f123ed6c 279 ProSitePatterns PS00683 Rhodanese C-terminal signature. 255 265 - T 09-03-2017 IPR001307 Thiosulphate sulfurtransferase, conserved site GO:0004792 KEGG: 00920+2.8.1.1|MetaCyc: PWY-5350 TK78_RS18850 9281bcb6d0e96c3f89fd7061f123ed6c 279 SMART SM00450 8 122 5.1E-19 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS18850 9281bcb6d0e96c3f89fd7061f123ed6c 279 SMART SM00450 144 271 1.8E-18 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS18850 9281bcb6d0e96c3f89fd7061f123ed6c 279 Gene3D G3DSA:3.40.250.10 149 275 1.1E-32 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS18850 9281bcb6d0e96c3f89fd7061f123ed6c 279 SUPERFAMILY SSF52821 4 141 5.11E-36 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS13825 6bfa48cd07e4659f27781a2ba9dc95ec 215 SUPERFAMILY SSF46689 15 76 1.89E-11 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS13825 6bfa48cd07e4659f27781a2ba9dc95ec 215 Gene3D G3DSA:1.10.357.10 12 192 1.8E-23 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS13825 6bfa48cd07e4659f27781a2ba9dc95ec 215 Pfam PF00440 Bacterial regulatory proteins, tetR family 30 62 8.7E-6 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS13825 6bfa48cd07e4659f27781a2ba9dc95ec 215 SUPERFAMILY SSF48498 98 202 1.25E-7 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS20015 d3389bf156a700cb641ae6d86ed7b21c 328 SUPERFAMILY SSF53850 14 228 3.74E-65 T 09-03-2017 TK78_RS20015 d3389bf156a700cb641ae6d86ed7b21c 328 Gene3D G3DSA:3.30.160.40 232 324 9.2E-24 T 09-03-2017 IPR022418 Porphobilinogen deaminase, C-terminal GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS20015 d3389bf156a700cb641ae6d86ed7b21c 328 PRINTS PR00151 Porphobilinogen deaminase signature 52 72 3.9E-18 T 09-03-2017 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS20015 d3389bf156a700cb641ae6d86ed7b21c 328 PRINTS PR00151 Porphobilinogen deaminase signature 83 102 3.9E-18 T 09-03-2017 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS20015 d3389bf156a700cb641ae6d86ed7b21c 328 PRINTS PR00151 Porphobilinogen deaminase signature 154 171 3.9E-18 T 09-03-2017 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS20015 d3389bf156a700cb641ae6d86ed7b21c 328 PRINTS PR00151 Porphobilinogen deaminase signature 241 258 3.9E-18 T 09-03-2017 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS20015 d3389bf156a700cb641ae6d86ed7b21c 328 Gene3D G3DSA:3.40.190.10 118 210 3.6E-33 T 09-03-2017 TK78_RS20015 d3389bf156a700cb641ae6d86ed7b21c 328 Pfam PF03900 Porphobilinogen deaminase, C-terminal domain 238 315 9.4E-18 T 09-03-2017 IPR022418 Porphobilinogen deaminase, C-terminal GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS20015 d3389bf156a700cb641ae6d86ed7b21c 328 Hamap MF_00260 Porphobilinogen deaminase [hemC]. 14 317 35.52 T 09-03-2017 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS20015 d3389bf156a700cb641ae6d86ed7b21c 328 PIRSF PIRSF001438 1 328 8.3E-112 T 09-03-2017 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS20015 d3389bf156a700cb641ae6d86ed7b21c 328 TIGRFAM TIGR00212 hemC: hydroxymethylbilane synthase 15 317 1.5E-86 T 09-03-2017 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS20015 d3389bf156a700cb641ae6d86ed7b21c 328 ProSitePatterns PS00533 Porphobilinogen deaminase cofactor-binding site. 242 258 - T 09-03-2017 IPR022419 Porphobilinogen deaminase, dipyrromethane cofactor binding site GO:0004418|GO:0018160|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS20015 d3389bf156a700cb641ae6d86ed7b21c 328 SUPERFAMILY SSF54782 231 325 5.23E-19 T 09-03-2017 IPR022418 Porphobilinogen deaminase, C-terminal GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS20015 d3389bf156a700cb641ae6d86ed7b21c 328 Gene3D G3DSA:3.40.190.10 13 117 5.7E-39 T 09-03-2017 TK78_RS20015 d3389bf156a700cb641ae6d86ed7b21c 328 Pfam PF01379 Porphobilinogen deaminase, dipyromethane cofactor binding domain 15 222 1.4E-67 T 09-03-2017 IPR022417 Porphobilinogen deaminase, N-terminal GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS08095 3f83df826a040f19226ab98beade1e6d 185 SUPERFAMILY SSF48498 79 183 2.75E-6 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS08095 3f83df826a040f19226ab98beade1e6d 185 Gene3D G3DSA:1.10.357.10 3 184 5.0E-25 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS08095 3f83df826a040f19226ab98beade1e6d 185 SUPERFAMILY SSF46689 3 74 1.4E-12 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS08095 3f83df826a040f19226ab98beade1e6d 185 Pfam PF00440 Bacterial regulatory proteins, tetR family 12 58 4.4E-13 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS08095 3f83df826a040f19226ab98beade1e6d 185 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 12 25 1.7E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS08095 3f83df826a040f19226ab98beade1e6d 185 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 33 56 1.7E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS00215 ea06ae4f99cf637339bcacd7b8ab70a1 109 Pfam PF02945 Recombination endonuclease VII 21 82 7.7E-7 T 09-03-2017 IPR004211 Recombination endonuclease VII TK78_RS00215 ea06ae4f99cf637339bcacd7b8ab70a1 109 SUPERFAMILY SSF54060 16 81 7.3E-6 T 09-03-2017 TK78_RS24695 dd0c61da8e65dce005b3cf36a2d7506d 629 Gene3D G3DSA:2.30.38.10 423 484 1.2E-21 T 09-03-2017 TK78_RS24695 dd0c61da8e65dce005b3cf36a2d7506d 629 Gene3D G3DSA:3.40.50.980 360 422 1.0E-25 T 09-03-2017 TK78_RS24695 dd0c61da8e65dce005b3cf36a2d7506d 629 Gene3D G3DSA:3.40.50.980 211 301 1.0E-25 T 09-03-2017 TK78_RS24695 dd0c61da8e65dce005b3cf36a2d7506d 629 SUPERFAMILY SSF56801 363 625 2.22E-118 T 09-03-2017 TK78_RS24695 dd0c61da8e65dce005b3cf36a2d7506d 629 SUPERFAMILY SSF56801 7 306 2.22E-118 T 09-03-2017 TK78_RS24695 dd0c61da8e65dce005b3cf36a2d7506d 629 ProSitePatterns PS00455 Putative AMP-binding domain signature. 204 215 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS24695 dd0c61da8e65dce005b3cf36a2d7506d 629 Pfam PF00501 AMP-binding enzyme 21 493 1.6E-94 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS24695 dd0c61da8e65dce005b3cf36a2d7506d 629 Gene3D G3DSA:3.40.50.980 14 157 2.9E-34 T 09-03-2017 TK78_RS24695 dd0c61da8e65dce005b3cf36a2d7506d 629 Gene3D G3DSA:3.40.50.980 189 210 2.9E-34 T 09-03-2017 TK78_RS19390 cd0de68c22826ea90fefe288153f0555 202 SMART SM00448 1 112 5.1E-28 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS19390 cd0de68c22826ea90fefe288153f0555 202 SUPERFAMILY SSF46894 129 201 5.44E-21 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS19390 cd0de68c22826ea90fefe288153f0555 202 Pfam PF00196 Bacterial regulatory proteins, luxR family 140 195 2.4E-18 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS19390 cd0de68c22826ea90fefe288153f0555 202 SUPERFAMILY SSF52172 1 129 6.97E-30 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS19390 cd0de68c22826ea90fefe288153f0555 202 ProSitePatterns PS00622 LuxR-type HTH domain signature. 155 182 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS19390 cd0de68c22826ea90fefe288153f0555 202 Gene3D G3DSA:1.10.10.10 143 201 8.2E-25 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS19390 cd0de68c22826ea90fefe288153f0555 202 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 141 155 3.4E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS19390 cd0de68c22826ea90fefe288153f0555 202 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 171 183 3.4E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS19390 cd0de68c22826ea90fefe288153f0555 202 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 155 171 3.4E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS19390 cd0de68c22826ea90fefe288153f0555 202 SMART SM00421 138 195 1.5E-23 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS19390 cd0de68c22826ea90fefe288153f0555 202 Gene3D G3DSA:3.40.50.2300 1 142 6.5E-35 T 09-03-2017 TK78_RS19390 cd0de68c22826ea90fefe288153f0555 202 Pfam PF00072 Response regulator receiver domain 1 113 4.8E-24 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS24795 a26e5d3845e718254d0691d1a1255ea3 330 TIGRFAM TIGR01430 aden_deam: adenosine deaminase 3 316 7.1E-111 T 09-03-2017 IPR006330 Adenosine/adenine deaminase GO:0019239 Reactome: R-HSA-74217 TK78_RS24795 a26e5d3845e718254d0691d1a1255ea3 330 Gene3D G3DSA:3.20.20.140 3 319 5.2E-97 T 09-03-2017 TK78_RS24795 a26e5d3845e718254d0691d1a1255ea3 330 Hamap MF_01962 Adenine deaminase. 2 311 80.776 T 09-03-2017 IPR028892 Adenine deaminase type 2 GO:0000034|GO:0006146 KEGG: 00230+3.5.4.2|MetaCyc: PWY-6610 TK78_RS24795 a26e5d3845e718254d0691d1a1255ea3 330 SUPERFAMILY SSF51556 4 315 1.1E-79 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS24795 a26e5d3845e718254d0691d1a1255ea3 330 Pfam PF00962 Adenosine/AMP deaminase 3 317 4.4E-69 T 09-03-2017 IPR001365 Adenosine/AMP deaminase domain GO:0019239 Reactome: R-HSA-74217 TK78_RS20440 097f2f97f6012ef36cfb2c3b1f225eda 134 Gene3D G3DSA:3.10.180.10 22 132 7.2E-11 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS20440 097f2f97f6012ef36cfb2c3b1f225eda 134 SUPERFAMILY SSF54593 21 132 1.61E-14 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS34160 3428f54dfba2d785654c5bb1bb97a16f 180 Pfam PF00440 Bacterial regulatory proteins, tetR family 15 61 4.3E-6 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS34160 3428f54dfba2d785654c5bb1bb97a16f 180 Gene3D G3DSA:1.10.357.10 11 179 3.9E-30 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS34160 3428f54dfba2d785654c5bb1bb97a16f 180 SUPERFAMILY SSF46689 7 78 1.54E-13 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS04180 c634dd52359beb6e1767fe24c6156a86 130 SUPERFAMILY SSF54593 1 125 5.92E-10 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS04180 c634dd52359beb6e1767fe24c6156a86 130 Gene3D G3DSA:3.10.180.10 4 125 5.6E-11 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS01500 d6df9fd95460e17159bd1ce2b0c23a90 321 Gene3D G3DSA:1.10.3720.10 92 310 2.1E-14 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS01500 d6df9fd95460e17159bd1ce2b0c23a90 321 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 116 317 9.2E-38 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS01500 d6df9fd95460e17159bd1ce2b0c23a90 321 SUPERFAMILY SSF161098 93 301 4.09E-13 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS08310 9234270f59acc3340cc82415c40e2b98 274 Gene3D G3DSA:3.40.1190.20 9 261 2.0E-100 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS08310 9234270f59acc3340cc82415c40e2b98 274 Pfam PF08543 Phosphomethylpyrimidine kinase 18 260 3.2E-91 T 09-03-2017 IPR013749 Pyridoxamine kinase/Phosphomethylpyrimidine kinase Reactome: R-HSA-964975 TK78_RS08310 9234270f59acc3340cc82415c40e2b98 274 TIGRFAM TIGR00097 HMP-P_kinase: hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 11 261 2.5E-92 T 09-03-2017 IPR004399 Hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase GO:0008972|GO:0009228 KEGG: 00730+2.7.1.49|MetaCyc: PWY-6910|MetaCyc: PWY-7356|MetaCyc: PWY-7357 TK78_RS08310 9234270f59acc3340cc82415c40e2b98 274 SUPERFAMILY SSF53613 8 264 5.77E-78 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS28675 797a58f9b218c1455eec15e4d4f01cec 218 TIGRFAM TIGR01528 NMN_trans_PnuC: nicotinamide mononucleotide transporter PnuC 23 204 4.2E-32 T 09-03-2017 IPR006419 Nicotinamide mononucleotide transporter PnuC GO:0016020|GO:0034257|GO:0034258 TK78_RS28675 797a58f9b218c1455eec15e4d4f01cec 218 Pfam PF04973 Nicotinamide mononucleotide transporter 23 203 2.4E-57 T 09-03-2017 IPR006419 Nicotinamide mononucleotide transporter PnuC GO:0016020|GO:0034257|GO:0034258 TK78_RS23285 49ee9e58418e7bed911b6daa256fb4fb 257 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 91 102 6.1E-11 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS23285 49ee9e58418e7bed911b6daa256fb4fb 257 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 142 150 6.1E-11 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS23285 49ee9e58418e7bed911b6daa256fb4fb 257 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 162 181 6.1E-11 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS23285 49ee9e58418e7bed911b6daa256fb4fb 257 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 13 254 9.1E-54 T 09-03-2017 TK78_RS23285 49ee9e58418e7bed911b6daa256fb4fb 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 91 102 2.2E-37 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS23285 49ee9e58418e7bed911b6daa256fb4fb 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 183 200 2.2E-37 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS23285 49ee9e58418e7bed911b6daa256fb4fb 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 162 181 2.2E-37 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS23285 49ee9e58418e7bed911b6daa256fb4fb 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 136 152 2.2E-37 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS23285 49ee9e58418e7bed911b6daa256fb4fb 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 219 239 2.2E-37 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS23285 49ee9e58418e7bed911b6daa256fb4fb 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 2.2E-37 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS23285 49ee9e58418e7bed911b6daa256fb4fb 257 Gene3D G3DSA:3.40.50.720 2 255 1.9E-77 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS23285 49ee9e58418e7bed911b6daa256fb4fb 257 SUPERFAMILY SSF51735 5 255 2.92E-72 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS23285 49ee9e58418e7bed911b6daa256fb4fb 257 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 149 177 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS11755 c53e95b35ec694d4a37c4a146fa9ef54 522 Gene3D G3DSA:3.40.50.410 342 505 2.1E-13 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS11755 c53e95b35ec694d4a37c4a146fa9ef54 522 Gene3D G3DSA:3.40.190.10 255 304 9.9E-10 T 09-03-2017 TK78_RS11755 c53e95b35ec694d4a37c4a146fa9ef54 522 Gene3D G3DSA:3.40.190.10 4 156 9.9E-10 T 09-03-2017 TK78_RS11755 c53e95b35ec694d4a37c4a146fa9ef54 522 SUPERFAMILY SSF53850 35 306 1.73E-16 T 09-03-2017 TK78_RS11755 c53e95b35ec694d4a37c4a146fa9ef54 522 SUPERFAMILY SSF53300 341 500 1.78E-20 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS11755 c53e95b35ec694d4a37c4a146fa9ef54 522 SMART SM00327 338 517 7.4E-9 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS11755 c53e95b35ec694d4a37c4a146fa9ef54 522 Pfam PF13531 Bacterial extracellular solute-binding protein 37 287 3.0E-20 T 09-03-2017 TK78_RS11755 c53e95b35ec694d4a37c4a146fa9ef54 522 Pfam PF13519 von Willebrand factor type A domain 341 449 1.6E-10 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS22530 bfa25cb02847d11d0c46ea908d576c3b 381 Gene3D G3DSA:3.10.180.10 14 187 5.8E-45 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS22530 bfa25cb02847d11d0c46ea908d576c3b 381 Gene3D G3DSA:3.10.180.10 188 381 8.9E-80 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS22530 bfa25cb02847d11d0c46ea908d576c3b 381 TIGRFAM TIGR01263 4HPPD: 4-hydroxyphenylpyruvate dioxygenase 22 381 1.1E-136 T 09-03-2017 IPR005956 4-hydroxyphenylpyruvate dioxygenase GO:0003868|GO:0009072|GO:0016701|GO:0055114 TK78_RS22530 bfa25cb02847d11d0c46ea908d576c3b 381 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 22 136 8.4E-5 T 09-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain TK78_RS22530 bfa25cb02847d11d0c46ea908d576c3b 381 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 185 335 8.3E-16 T 09-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain TK78_RS22530 bfa25cb02847d11d0c46ea908d576c3b 381 SUPERFAMILY SSF54593 14 368 4.54E-91 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS22530 bfa25cb02847d11d0c46ea908d576c3b 381 PIRSF PIRSF009283 8 381 9.4E-137 T 09-03-2017 IPR005956 4-hydroxyphenylpyruvate dioxygenase GO:0003868|GO:0009072|GO:0016701|GO:0055114 TK78_RS34225 c4ade3c7d9d38ca726da4e96dcc03288 189 Pfam PF04978 Protein of unknown function (DUF664) 15 185 8.7E-43 T 09-03-2017 IPR007061 Protein of unknown function DUF664 TK78_RS34225 c4ade3c7d9d38ca726da4e96dcc03288 189 SUPERFAMILY SSF109854 9 184 8.09E-34 T 09-03-2017 TK78_RS34225 c4ade3c7d9d38ca726da4e96dcc03288 189 Gene3D G3DSA:1.20.120.450 9 187 2.1E-42 T 09-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase TK78_RS24550 0847cfaa442f18dc95de3adb1d893fe5 412 Pfam PF00535 Glycosyl transferase family 2 14 172 8.0E-29 T 09-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 TK78_RS24550 0847cfaa442f18dc95de3adb1d893fe5 412 SUPERFAMILY SSF53448 8 224 1.35E-45 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS24550 0847cfaa442f18dc95de3adb1d893fe5 412 Gene3D G3DSA:3.90.550.10 9 204 1.4E-44 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS24825 2d3bbe4a25eb0688c9954b4bf0783b82 117 SUPERFAMILY SSF142906 1 114 1.7E-40 T 09-03-2017 TK78_RS24825 2d3bbe4a25eb0688c9954b4bf0783b82 117 Pfam PF04237 YjbR 11 101 8.5E-30 T 09-03-2017 IPR007351 Uncharacterised protein YjbR TK78_RS04815 cc60249f4d54d21e9679dcc69712f9d2 281 Pfam PF00005 ABC transporter 28 182 1.7E-27 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS04815 cc60249f4d54d21e9679dcc69712f9d2 281 SMART SM00382 37 229 6.9E-13 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS04815 cc60249f4d54d21e9679dcc69712f9d2 281 Gene3D G3DSA:3.40.50.300 10 249 1.3E-55 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS04815 cc60249f4d54d21e9679dcc69712f9d2 281 ProSitePatterns PS00211 ABC transporters family signature. 154 168 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS04815 cc60249f4d54d21e9679dcc69712f9d2 281 SUPERFAMILY SSF52540 11 240 9.75E-56 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS34860 f272d185e3bfab1ce06e10b3228fcb02 764 Gene3D G3DSA:1.10.443.10 423 608 4.1E-24 T 09-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 TK78_RS34860 f272d185e3bfab1ce06e10b3228fcb02 764 Pfam PF00589 Phage integrase family 432 599 6.2E-14 T 09-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 TK78_RS34860 f272d185e3bfab1ce06e10b3228fcb02 764 SUPERFAMILY SSF56349 421 608 3.83E-23 T 09-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 TK78_RS00015 f272d185e3bfab1ce06e10b3228fcb02 764 Gene3D G3DSA:1.10.443.10 423 608 4.1E-24 T 09-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 TK78_RS00015 f272d185e3bfab1ce06e10b3228fcb02 764 Pfam PF00589 Phage integrase family 432 599 6.2E-14 T 09-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 TK78_RS00015 f272d185e3bfab1ce06e10b3228fcb02 764 SUPERFAMILY SSF56349 421 608 3.83E-23 T 09-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 TK78_RS02710 f3b81493e342fe8a978c97ccf295800c 263 Gene3D G3DSA:3.40.50.720 6 249 2.7E-72 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS02710 f3b81493e342fe8a978c97ccf295800c 263 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 22 247 8.0E-53 T 09-03-2017 TK78_RS02710 f3b81493e342fe8a978c97ccf295800c 263 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 14 183 0.0014 T 09-03-2017 TK78_RS02710 f3b81493e342fe8a978c97ccf295800c 263 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 145 173 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS02710 f3b81493e342fe8a978c97ccf295800c 263 SUPERFAMILY SSF51735 13 247 6.58E-70 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS02710 f3b81493e342fe8a978c97ccf295800c 263 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 138 146 4.1E-13 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS02710 f3b81493e342fe8a978c97ccf295800c 263 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 158 177 4.1E-13 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS02710 f3b81493e342fe8a978c97ccf295800c 263 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 84 95 4.1E-13 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS02710 f3b81493e342fe8a978c97ccf295800c 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 15 32 5.8E-40 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS02710 f3b81493e342fe8a978c97ccf295800c 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 132 148 5.8E-40 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS02710 f3b81493e342fe8a978c97ccf295800c 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 212 232 5.8E-40 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS02710 f3b81493e342fe8a978c97ccf295800c 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 158 177 5.8E-40 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS02710 f3b81493e342fe8a978c97ccf295800c 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 84 95 5.8E-40 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS02710 f3b81493e342fe8a978c97ccf295800c 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 178 195 5.8E-40 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS23525 fd3ae22c103fb2913315de6b93d23fb9 385 ProSitePatterns PS00073 Acyl-CoA dehydrogenases signature 2. 342 361 - T 09-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 TK78_RS23525 fd3ae22c103fb2913315de6b93d23fb9 385 SUPERFAMILY SSF47203 233 383 1.22E-46 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS23525 fd3ae22c103fb2913315de6b93d23fb9 385 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 235 383 6.1E-44 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS23525 fd3ae22c103fb2913315de6b93d23fb9 385 SUPERFAMILY SSF56645 4 246 7.98E-77 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS23525 fd3ae22c103fb2913315de6b93d23fb9 385 Gene3D G3DSA:2.40.110.10 122 223 2.8E-36 T 09-03-2017 TK78_RS23525 fd3ae22c103fb2913315de6b93d23fb9 385 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 7 119 8.8E-31 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS23525 fd3ae22c103fb2913315de6b93d23fb9 385 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 123 223 3.9E-25 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS23525 fd3ae22c103fb2913315de6b93d23fb9 385 Gene3D G3DSA:1.10.540.10 6 120 2.1E-33 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS23525 fd3ae22c103fb2913315de6b93d23fb9 385 Gene3D G3DSA:1.20.140.10 224 383 1.9E-55 T 09-03-2017 TK78_RS05985 f50381002e64d6ef81a1c9780abdac60 488 PIRSF PIRSF006060 2 488 1.4E-92 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS05985 f50381002e64d6ef81a1c9780abdac60 488 Pfam PF13520 Amino acid permease 25 454 6.7E-53 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS05185 f3c5cb8e2e009481ec91328e2c5aa565 167 SMART SM00903 22 166 2.4E-43 T 09-03-2017 IPR002563 Flavin reductase like domain GO:0010181 TK78_RS05185 f3c5cb8e2e009481ec91328e2c5aa565 167 Pfam PF01613 Flavin reductase like domain 22 167 3.2E-36 T 09-03-2017 IPR002563 Flavin reductase like domain GO:0010181 TK78_RS05185 f3c5cb8e2e009481ec91328e2c5aa565 167 SUPERFAMILY SSF50475 15 166 4.66E-43 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS05185 f3c5cb8e2e009481ec91328e2c5aa565 167 Gene3D G3DSA:2.30.110.10 14 165 1.8E-50 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS07895 435d7eeca58efc0838798302bc3db9db 481 SUPERFAMILY SSF53720 4 475 3.01E-131 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS07895 435d7eeca58efc0838798302bc3db9db 481 Pfam PF00171 Aldehyde dehydrogenase family 18 471 7.9E-132 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS07895 435d7eeca58efc0838798302bc3db9db 481 Gene3D G3DSA:3.40.605.10 4 265 1.3E-69 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS07895 435d7eeca58efc0838798302bc3db9db 481 Gene3D G3DSA:3.40.309.10 266 450 1.1E-53 T 09-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 TK78_RS33355 cfaf3801833eb0235b27c9ff3973501f 417 Pfam PF00174 Oxidoreductase molybdopterin binding domain 102 279 2.7E-51 T 09-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 TK78_RS33355 cfaf3801833eb0235b27c9ff3973501f 417 Gene3D G3DSA:2.60.40.650 321 416 4.8E-20 T 09-03-2017 IPR005066 Moybdenum cofactor oxidoreductase, dimerisation GO:0016491|GO:0030151|GO:0055114 Reactome: R-HSA-1614517 TK78_RS33355 cfaf3801833eb0235b27c9ff3973501f 417 Pfam PF03404 Mo-co oxidoreductase dimerisation domain 326 408 4.1E-6 T 09-03-2017 IPR005066 Moybdenum cofactor oxidoreductase, dimerisation GO:0016491|GO:0030151|GO:0055114 Reactome: R-HSA-1614517 TK78_RS33355 cfaf3801833eb0235b27c9ff3973501f 417 SUPERFAMILY SSF81296 314 416 2.03E-22 T 09-03-2017 IPR014756 Immunoglobulin E-set TK78_RS33355 cfaf3801833eb0235b27c9ff3973501f 417 SUPERFAMILY SSF56524 70 295 1.31E-62 T 09-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 TK78_RS33355 cfaf3801833eb0235b27c9ff3973501f 417 PRINTS PR00407 Eukaryotic molybdopterin domain signature 90 106 7.4E-26 T 09-03-2017 IPR008335 Eukaryotic molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-1614517 TK78_RS33355 cfaf3801833eb0235b27c9ff3973501f 417 PRINTS PR00407 Eukaryotic molybdopterin domain signature 260 273 7.4E-26 T 09-03-2017 IPR008335 Eukaryotic molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-1614517 TK78_RS33355 cfaf3801833eb0235b27c9ff3973501f 417 PRINTS PR00407 Eukaryotic molybdopterin domain signature 172 187 7.4E-26 T 09-03-2017 IPR008335 Eukaryotic molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-1614517 TK78_RS33355 cfaf3801833eb0235b27c9ff3973501f 417 PRINTS PR00407 Eukaryotic molybdopterin domain signature 339 351 7.4E-26 T 09-03-2017 IPR008335 Eukaryotic molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-1614517 TK78_RS33355 cfaf3801833eb0235b27c9ff3973501f 417 PRINTS PR00407 Eukaryotic molybdopterin domain signature 227 243 7.4E-26 T 09-03-2017 IPR008335 Eukaryotic molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-1614517 TK78_RS33355 cfaf3801833eb0235b27c9ff3973501f 417 PRINTS PR00407 Eukaryotic molybdopterin domain signature 384 396 7.4E-26 T 09-03-2017 IPR008335 Eukaryotic molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-1614517 TK78_RS33355 cfaf3801833eb0235b27c9ff3973501f 417 PRINTS PR00407 Eukaryotic molybdopterin domain signature 244 257 7.4E-26 T 09-03-2017 IPR008335 Eukaryotic molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-1614517 TK78_RS33355 cfaf3801833eb0235b27c9ff3973501f 417 Gene3D G3DSA:3.90.420.10 74 293 2.7E-69 T 09-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 TK78_RS20200 a5efc0bd0b6abbe87199fb4ca8e25ca9 195 TIGRFAM TIGR03086 TIGR03086: TIGR03086 family protein 10 183 9.8E-40 T 09-03-2017 IPR017520 Conserved hypothetical protein CHP03086 TK78_RS20200 a5efc0bd0b6abbe87199fb4ca8e25ca9 195 SUPERFAMILY SSF109854 7 132 4.58E-15 T 09-03-2017 TK78_RS20200 a5efc0bd0b6abbe87199fb4ca8e25ca9 195 TIGRFAM TIGR03083 TIGR03083: uncharacterized Actinobacterial protein TIGR03083 9 183 3.7E-19 T 09-03-2017 IPR017517 Conserved hypothetical protein CHP03083, actinobacterial-type TK78_RS20200 a5efc0bd0b6abbe87199fb4ca8e25ca9 195 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 9 127 1.6E-8 T 09-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 TK78_RS14310 3177eeba87b16b7ca32db12f1ff76fa7 216 Pfam PF00857 Isochorismatase family 19 168 1.2E-25 T 09-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 TK78_RS14310 3177eeba87b16b7ca32db12f1ff76fa7 216 Gene3D G3DSA:3.40.50.850 12 205 1.4E-39 T 09-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 TK78_RS14310 3177eeba87b16b7ca32db12f1ff76fa7 216 SUPERFAMILY SSF52499 10 207 1.44E-44 T 09-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 TK78_RS10105 942bc49088a62f03f72831963bfdf440 132 Gene3D G3DSA:1.10.1660.10 56 114 2.5E-11 T 09-03-2017 TK78_RS10105 942bc49088a62f03f72831963bfdf440 132 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 13 26 7.8E-8 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS10105 942bc49088a62f03f72831963bfdf440 132 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 37 57 7.8E-8 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS10105 942bc49088a62f03f72831963bfdf440 132 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 2 13 7.8E-8 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS10105 942bc49088a62f03f72831963bfdf440 132 SUPERFAMILY SSF46955 1 114 4.4E-28 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS10105 942bc49088a62f03f72831963bfdf440 132 Gene3D G3DSA:1.10.1660.10 1 55 1.2E-25 T 09-03-2017 TK78_RS10105 942bc49088a62f03f72831963bfdf440 132 SMART SM00422 1 70 1.9E-32 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS10105 942bc49088a62f03f72831963bfdf440 132 ProSitePatterns PS00552 MerR-type HTH domain signature. 4 26 - T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS10105 942bc49088a62f03f72831963bfdf440 132 Pfam PF13411 MerR HTH family regulatory protein 1 69 2.3E-18 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS05115 b20b83dab0932ae6c90ff5be2145e6bc 499 PRINTS PR01036 Tetracycline resistance protein TetB signature 30 54 1.4E-9 T 09-03-2017 TK78_RS05115 b20b83dab0932ae6c90ff5be2145e6bc 499 PRINTS PR01036 Tetracycline resistance protein TetB signature 121 141 1.4E-9 T 09-03-2017 TK78_RS05115 b20b83dab0932ae6c90ff5be2145e6bc 499 PRINTS PR01036 Tetracycline resistance protein TetB signature 151 175 1.4E-9 T 09-03-2017 TK78_RS05115 b20b83dab0932ae6c90ff5be2145e6bc 499 Gene3D G3DSA:1.20.1250.20 279 472 4.2E-19 T 09-03-2017 TK78_RS05115 b20b83dab0932ae6c90ff5be2145e6bc 499 Pfam PF07690 Major Facilitator Superfamily 32 434 3.3E-52 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS05115 b20b83dab0932ae6c90ff5be2145e6bc 499 ProSitePatterns PS00217 Sugar transport proteins signature 2. 123 148 - T 09-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 TK78_RS05115 b20b83dab0932ae6c90ff5be2145e6bc 499 SUPERFAMILY SSF103473 20 217 2.88E-75 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS05115 b20b83dab0932ae6c90ff5be2145e6bc 499 SUPERFAMILY SSF103473 270 488 2.88E-75 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS05115 b20b83dab0932ae6c90ff5be2145e6bc 499 Gene3D G3DSA:1.20.1250.20 20 215 8.4E-39 T 09-03-2017 TK78_RS05115 b20b83dab0932ae6c90ff5be2145e6bc 499 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 28 440 4.1E-69 T 09-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 TK78_RS02160 68d1cc5c4d794c08ef13275eb7783231 271 Gene3D G3DSA:3.40.630.30 34 172 3.1E-29 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS02160 68d1cc5c4d794c08ef13275eb7783231 271 SUPERFAMILY SSF55729 29 240 8.38E-40 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS02160 68d1cc5c4d794c08ef13275eb7783231 271 Pfam PF13444 Acetyltransferase (GNAT) domain 48 149 3.9E-31 T 09-03-2017 TK78_RS12860 cdf35cc98b69397e64d32030ff8b96c2 390 SUPERFAMILY SSF50621 244 379 1.64E-46 T 09-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 TK78_RS12860 cdf35cc98b69397e64d32030ff8b96c2 390 ProSitePatterns PS00395 Alanine racemase pyridoxal-phosphate attachment site. 36 46 - T 09-03-2017 IPR020622 Alanine racemase, pyridoxal-phosphate attachment site KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TK78_RS12860 cdf35cc98b69397e64d32030ff8b96c2 390 SMART SM01005 250 377 4.3E-63 T 09-03-2017 IPR011079 Alanine racemase, C-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TK78_RS12860 cdf35cc98b69397e64d32030ff8b96c2 390 PRINTS PR00992 Alanine racemase signature 67 85 3.0E-60 T 09-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TK78_RS12860 cdf35cc98b69397e64d32030ff8b96c2 390 PRINTS PR00992 Alanine racemase signature 128 140 3.0E-60 T 09-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TK78_RS12860 cdf35cc98b69397e64d32030ff8b96c2 390 PRINTS PR00992 Alanine racemase signature 359 372 3.0E-60 T 09-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TK78_RS12860 cdf35cc98b69397e64d32030ff8b96c2 390 PRINTS PR00992 Alanine racemase signature 165 176 3.0E-60 T 09-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TK78_RS12860 cdf35cc98b69397e64d32030ff8b96c2 390 PRINTS PR00992 Alanine racemase signature 208 235 3.0E-60 T 09-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TK78_RS12860 cdf35cc98b69397e64d32030ff8b96c2 390 PRINTS PR00992 Alanine racemase signature 31 47 3.0E-60 T 09-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TK78_RS12860 cdf35cc98b69397e64d32030ff8b96c2 390 PRINTS PR00992 Alanine racemase signature 266 281 3.0E-60 T 09-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TK78_RS12860 cdf35cc98b69397e64d32030ff8b96c2 390 PRINTS PR00992 Alanine racemase signature 283 298 3.0E-60 T 09-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TK78_RS12860 cdf35cc98b69397e64d32030ff8b96c2 390 PRINTS PR00992 Alanine racemase signature 304 321 3.0E-60 T 09-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TK78_RS12860 cdf35cc98b69397e64d32030ff8b96c2 390 SUPERFAMILY SSF51419 13 251 2.47E-64 T 09-03-2017 IPR029066 PLP-binding barrel TK78_RS12860 cdf35cc98b69397e64d32030ff8b96c2 390 Gene3D G3DSA:3.20.20.10 15 228 1.4E-70 T 09-03-2017 IPR029066 PLP-binding barrel TK78_RS12860 cdf35cc98b69397e64d32030ff8b96c2 390 Hamap MF_01201 Alanine racemase. 6 377 31.993 T 09-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TK78_RS12860 cdf35cc98b69397e64d32030ff8b96c2 390 Pfam PF01168 Alanine racemase, N-terminal domain 13 235 6.3E-66 T 09-03-2017 IPR001608 Alanine racemase, N-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TK78_RS12860 cdf35cc98b69397e64d32030ff8b96c2 390 Gene3D G3DSA:2.40.37.10 229 380 1.0E-58 T 09-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 TK78_RS12860 cdf35cc98b69397e64d32030ff8b96c2 390 TIGRFAM TIGR00492 alr: alanine racemase 9 377 2.6E-90 T 09-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TK78_RS12860 cdf35cc98b69397e64d32030ff8b96c2 390 Pfam PF00842 Alanine racemase, C-terminal domain 250 376 3.5E-39 T 09-03-2017 IPR011079 Alanine racemase, C-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TK78_RS28230 5edf34ce18cf56d8e1229c3cefbad0f8 678 SMART SM00327 492 669 1.4E-20 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS28230 5edf34ce18cf56d8e1229c3cefbad0f8 678 TIGRFAM TIGR02442 Cob-chelat-sub: cobaltochelatase subunit 5 657 4.7E-256 T 09-03-2017 IPR012804 Cobaltochelatase subunit, putative TK78_RS28230 5edf34ce18cf56d8e1229c3cefbad0f8 678 Pfam PF01078 Magnesium chelatase, subunit ChlI 113 182 4.9E-7 T 09-03-2017 IPR000523 Magnesium chelatase ChlI domain TK78_RS28230 5edf34ce18cf56d8e1229c3cefbad0f8 678 Pfam PF13519 von Willebrand factor type A domain 495 601 7.1E-17 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS28230 5edf34ce18cf56d8e1229c3cefbad0f8 678 SUPERFAMILY SSF52540 4 327 4.52E-59 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28230 5edf34ce18cf56d8e1229c3cefbad0f8 678 Gene3D G3DSA:3.40.50.410 495 620 8.9E-15 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS28230 5edf34ce18cf56d8e1229c3cefbad0f8 678 Gene3D G3DSA:1.10.8.80 248 334 1.2E-34 T 09-03-2017 TK78_RS28230 5edf34ce18cf56d8e1229c3cefbad0f8 678 SMART SM00382 28 205 4.0E-7 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS28230 5edf34ce18cf56d8e1229c3cefbad0f8 678 Gene3D G3DSA:3.40.50.300 4 201 2.1E-54 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28230 5edf34ce18cf56d8e1229c3cefbad0f8 678 SUPERFAMILY SSF53300 495 658 1.47E-23 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS01235 1ccd70baa9a29664685a9a424b2b624b 572 Pfam PF00664 ABC transporter transmembrane region 32 299 6.5E-25 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS01235 1ccd70baa9a29664685a9a424b2b624b 572 SUPERFAMILY SSF90123 18 328 3.66E-52 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS01235 1ccd70baa9a29664685a9a424b2b624b 572 Gene3D G3DSA:3.40.50.300 353 566 5.1E-55 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01235 1ccd70baa9a29664685a9a424b2b624b 572 SMART SM00382 381 568 1.4E-11 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS01235 1ccd70baa9a29664685a9a424b2b624b 572 Gene3D G3DSA:1.20.1560.10 18 335 5.6E-50 T 09-03-2017 TK78_RS01235 1ccd70baa9a29664685a9a424b2b624b 572 Pfam PF00005 ABC transporter 374 521 3.3E-28 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS01235 1ccd70baa9a29664685a9a424b2b624b 572 ProSitePatterns PS00211 ABC transporters family signature. 493 507 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS01235 1ccd70baa9a29664685a9a424b2b624b 572 SUPERFAMILY SSF52540 347 568 2.31E-56 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08170 594213d2b3606b76cebb3cfae91b2cce 146 Hamap MF_00385 30S ribosomal protein S16 [rpsP]. 2 77 23.556 T 09-03-2017 IPR000307 Ribosomal protein S16 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS08170 594213d2b3606b76cebb3cfae91b2cce 146 SUPERFAMILY SSF54565 2 93 1.09E-33 T 09-03-2017 IPR023803 Ribosomal protein S16 domain Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS08170 594213d2b3606b76cebb3cfae91b2cce 146 ProSitePatterns PS00732 Ribosomal protein S16 signature. 3 12 - T 09-03-2017 IPR020592 Ribosomal protein S16, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS08170 594213d2b3606b76cebb3cfae91b2cce 146 Gene3D G3DSA:3.30.1320.10 2 83 9.4E-33 T 09-03-2017 IPR023803 Ribosomal protein S16 domain Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS08170 594213d2b3606b76cebb3cfae91b2cce 146 Pfam PF00886 Ribosomal protein S16 9 67 6.1E-24 T 09-03-2017 IPR000307 Ribosomal protein S16 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS08170 594213d2b3606b76cebb3cfae91b2cce 146 TIGRFAM TIGR00002 S16: ribosomal protein bS16 3 79 5.4E-32 T 09-03-2017 IPR000307 Ribosomal protein S16 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS18275 e318c1f2dcc797a264e36eb1a2052f70 357 Hamap MF_00741 Phosphoribosylformylglycinamidine cyclo-ligase [purM]. 7 351 40.038 T 09-03-2017 IPR004733 Phosphoribosylformylglycinamidine cyclo-ligase GO:0004641|GO:0005737|GO:0006189 KEGG: 00230+6.3.3.1|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 TK78_RS18275 e318c1f2dcc797a264e36eb1a2052f70 357 SUPERFAMILY SSF56042 176 345 4.78E-52 T 09-03-2017 IPR010918 AIR synthase-related protein, C-terminal domain TK78_RS18275 e318c1f2dcc797a264e36eb1a2052f70 357 Pfam PF00586 AIR synthase related protein, N-terminal domain 65 168 2.7E-15 T 09-03-2017 IPR016188 PurM-like, N-terminal domain TK78_RS18275 e318c1f2dcc797a264e36eb1a2052f70 357 TIGRFAM TIGR00878 purM: phosphoribosylformylglycinamidine cyclo-ligase 8 341 5.0E-124 T 09-03-2017 IPR004733 Phosphoribosylformylglycinamidine cyclo-ligase GO:0004641|GO:0005737|GO:0006189 KEGG: 00230+6.3.3.1|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 TK78_RS18275 e318c1f2dcc797a264e36eb1a2052f70 357 Gene3D G3DSA:3.90.650.10 176 345 3.7E-62 T 09-03-2017 IPR010918 AIR synthase-related protein, C-terminal domain TK78_RS18275 e318c1f2dcc797a264e36eb1a2052f70 357 SUPERFAMILY SSF55326 8 173 1.03E-41 T 09-03-2017 TK78_RS18275 e318c1f2dcc797a264e36eb1a2052f70 357 Pfam PF02769 AIR synthase related protein, C-terminal domain 180 345 1.1E-30 T 09-03-2017 IPR010918 AIR synthase-related protein, C-terminal domain TK78_RS18275 e318c1f2dcc797a264e36eb1a2052f70 357 Gene3D G3DSA:3.30.1330.10 23 173 8.2E-49 T 09-03-2017 IPR016188 PurM-like, N-terminal domain TK78_RS06725 a56e399205fe951c1038ddbbd19c85bb 358 Gene3D G3DSA:3.90.1720.10 199 358 1.3E-18 T 09-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain TK78_RS06725 a56e399205fe951c1038ddbbd19c85bb 358 SUPERFAMILY SSF54001 199 358 7.19E-12 T 09-03-2017 TK78_RS06725 a56e399205fe951c1038ddbbd19c85bb 358 Pfam PF00877 NlpC/P60 family 221 344 3.6E-6 T 09-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain TK78_RS19200 556834ef1bc4f1590a406ba3066066c7 507 Gene3D G3DSA:2.30.38.10 332 406 8.7E-15 T 09-03-2017 TK78_RS19200 556834ef1bc4f1590a406ba3066066c7 507 Gene3D G3DSA:3.30.300.30 407 504 1.6E-20 T 09-03-2017 TK78_RS19200 556834ef1bc4f1590a406ba3066066c7 507 Pfam PF00501 AMP-binding enzyme 17 412 5.3E-63 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS19200 556834ef1bc4f1590a406ba3066066c7 507 ProSitePatterns PS00455 Putative AMP-binding domain signature. 159 170 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS19200 556834ef1bc4f1590a406ba3066066c7 507 Gene3D G3DSA:3.40.50.980 169 331 1.6E-29 T 09-03-2017 TK78_RS19200 556834ef1bc4f1590a406ba3066066c7 507 SUPERFAMILY SSF56801 3 504 2.75E-102 T 09-03-2017 TK78_RS19200 556834ef1bc4f1590a406ba3066066c7 507 Gene3D G3DSA:3.40.50.980 3 168 8.2E-27 T 09-03-2017 TK78_RS29215 1c6b547624580756ec442674f1c8ae33 327 SUPERFAMILY SSF51430 1 316 9.17E-91 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS29215 1c6b547624580756ec442674f1c8ae33 327 Gene3D G3DSA:3.20.20.100 9 321 3.4E-90 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS29215 1c6b547624580756ec442674f1c8ae33 327 Pfam PF00248 Aldo/keto reductase family 15 312 3.6E-59 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS28590 9414cf795196ba73c1130a08f5a0bac1 271 SMART SM00363 7 74 2.2E-5 T 09-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 TK78_RS28590 9414cf795196ba73c1130a08f5a0bac1 271 Pfam PF01479 S4 domain 7 49 2.2E-9 T 09-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 TK78_RS28590 9414cf795196ba73c1130a08f5a0bac1 271 SUPERFAMILY SSF55174 6 65 5.55E-11 T 09-03-2017 TK78_RS28590 9414cf795196ba73c1130a08f5a0bac1 271 Gene3D G3DSA:3.10.290.10 7 98 1.6E-23 T 09-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 TK78_RS28590 9414cf795196ba73c1130a08f5a0bac1 271 Pfam PF01728 FtsJ-like methyltransferase 65 250 9.7E-17 T 09-03-2017 IPR002877 Ribosomal RNA methyltransferase FtsJ domain GO:0008168|GO:0032259 TK78_RS28590 9414cf795196ba73c1130a08f5a0bac1 271 Gene3D G3DSA:3.40.50.150 99 185 1.8E-6 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS28590 9414cf795196ba73c1130a08f5a0bac1 271 TIGRFAM TIGR00478 tly: TlyA family rRNA methyltransferase/putative hemolysin 8 245 7.2E-61 T 09-03-2017 IPR004538 Haemolysin A /rRNA methyltransferase TlyA GO:0003723 TK78_RS28590 9414cf795196ba73c1130a08f5a0bac1 271 SUPERFAMILY SSF53335 64 251 9.14E-22 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS28590 9414cf795196ba73c1130a08f5a0bac1 271 PIRSF PIRSF005578 3 268 1.9E-94 T 09-03-2017 IPR004538 Haemolysin A /rRNA methyltransferase TlyA GO:0003723 TK78_RS25145 acf0e0853b52c0a62e99d3fc4777e70c 377 ProSitePatterns PS00211 ABC transporters family signature. 131 145 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS25145 acf0e0853b52c0a62e99d3fc4777e70c 377 Pfam PF08402 TOBE domain 272 340 2.0E-8 T 09-03-2017 IPR013611 Transport-associated OB, type 2 GO:0005215|GO:0005524|GO:0006810|GO:0016820|GO:0043190 TK78_RS25145 acf0e0853b52c0a62e99d3fc4777e70c 377 SUPERFAMILY SSF52540 1 238 2.46E-85 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS25145 acf0e0853b52c0a62e99d3fc4777e70c 377 SMART SM00382 25 208 6.1E-21 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS25145 acf0e0853b52c0a62e99d3fc4777e70c 377 Pfam PF00005 ABC transporter 16 158 4.7E-34 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS25145 acf0e0853b52c0a62e99d3fc4777e70c 377 SUPERFAMILY SSF50331 234 333 4.76E-10 T 09-03-2017 IPR008995 Molybdate/tungstate binding, C-terminal TK78_RS25145 acf0e0853b52c0a62e99d3fc4777e70c 377 Gene3D G3DSA:3.40.50.300 1 230 6.4E-80 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29430 5db78fb5398a8b3bd2ab1b9215be13ce 946 Gene3D G3DSA:3.40.50.300 369 456 5.0E-17 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29430 5db78fb5398a8b3bd2ab1b9215be13ce 946 Gene3D G3DSA:3.40.50.300 295 327 5.0E-17 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29430 5db78fb5398a8b3bd2ab1b9215be13ce 946 Pfam PF00271 Helicase conserved C-terminal domain 367 446 1.5E-4 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS29430 5db78fb5398a8b3bd2ab1b9215be13ce 946 Gene3D G3DSA:3.40.50.300 33 216 6.1E-38 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29430 5db78fb5398a8b3bd2ab1b9215be13ce 946 Pfam PF08148 DSHCT (NUC185) domain 766 940 3.3E-37 T 09-03-2017 IPR012961 ATP-dependent RNA helicase Ski2, C-terminal TK78_RS29430 5db78fb5398a8b3bd2ab1b9215be13ce 946 SMART SM00487 32 214 4.6E-31 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS29430 5db78fb5398a8b3bd2ab1b9215be13ce 946 SMART SM00490 357 446 5.0E-13 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS29430 5db78fb5398a8b3bd2ab1b9215be13ce 946 Pfam PF00270 DEAD/DEAH box helicase 38 186 1.5E-20 T 09-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 TK78_RS29430 5db78fb5398a8b3bd2ab1b9215be13ce 946 SUPERFAMILY SSF52540 366 459 6.4E-44 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29430 5db78fb5398a8b3bd2ab1b9215be13ce 946 SUPERFAMILY SSF52540 46 187 6.4E-44 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29430 5db78fb5398a8b3bd2ab1b9215be13ce 946 SUPERFAMILY SSF52540 272 324 6.4E-44 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29430 5db78fb5398a8b3bd2ab1b9215be13ce 946 SMART SM01142 763 945 1.2E-61 T 09-03-2017 IPR012961 ATP-dependent RNA helicase Ski2, C-terminal TK78_RS29430 5db78fb5398a8b3bd2ab1b9215be13ce 946 Pfam PF13234 rRNA-processing arch domain 502 603 7.6E-5 T 09-03-2017 IPR025696 rRNA-processing arch domain TK78_RS01865 42decd0139a078abdb12d7f244bb978f 709 Pfam PF05378 Hydantoinase/oxoprolinase N-terminal region 7 175 2.1E-31 T 09-03-2017 IPR008040 Hydantoinaseoxoprolinase, N-terminal Reactome: R-HSA-174403|Reactome: R-HSA-5578998 TK78_RS01865 42decd0139a078abdb12d7f244bb978f 709 SUPERFAMILY SSF53067 252 301 7.54E-11 T 09-03-2017 TK78_RS01865 42decd0139a078abdb12d7f244bb978f 709 SUPERFAMILY SSF53067 358 495 7.54E-11 T 09-03-2017 TK78_RS01865 42decd0139a078abdb12d7f244bb978f 709 SUPERFAMILY SSF53067 7 87 7.54E-11 T 09-03-2017 TK78_RS01865 42decd0139a078abdb12d7f244bb978f 709 Gene3D G3DSA:3.30.420.40 3 65 3.3E-6 T 09-03-2017 TK78_RS01865 42decd0139a078abdb12d7f244bb978f 709 Pfam PF01968 Hydantoinase/oxoprolinase 194 501 4.1E-76 T 09-03-2017 IPR002821 Hydantoinase/oxoprolinase GO:0016787 Reactome: R-HSA-174403|Reactome: R-HSA-5578998 TK78_RS21640 da9ea9b56d24468694645e75fe4df3a6 333 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 69 247 1.2E-22 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS21640 da9ea9b56d24468694645e75fe4df3a6 333 SUPERFAMILY SSF52266 64 262 3.66E-29 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS21640 da9ea9b56d24468694645e75fe4df3a6 333 Gene3D G3DSA:3.40.50.1110 65 260 4.0E-24 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS26065 8a0188467d3e9acc9eecc620813cadc5 211 SUPERFAMILY SSF48498 91 207 3.29E-28 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS26065 8a0188467d3e9acc9eecc620813cadc5 211 Pfam PF00440 Bacterial regulatory proteins, tetR family 33 76 3.2E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS26065 8a0188467d3e9acc9eecc620813cadc5 211 Pfam PF16859 Bacterial transcriptional repressor C-terminal 90 199 9.4E-30 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS26065 8a0188467d3e9acc9eecc620813cadc5 211 Gene3D G3DSA:1.10.10.60 22 70 1.1E-20 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS26065 8a0188467d3e9acc9eecc620813cadc5 211 Gene3D G3DSA:1.10.357.10 72 209 5.5E-46 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS26065 8a0188467d3e9acc9eecc620813cadc5 211 SUPERFAMILY SSF46689 23 85 1.1E-13 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS26720 91893d78e53a6f0f2212b27ccb741142 730 Gene3D G3DSA:1.25.40.10 104 404 3.8E-16 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS26720 91893d78e53a6f0f2212b27ccb741142 730 SUPERFAMILY SSF48452 232 396 6.07E-8 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS26720 91893d78e53a6f0f2212b27ccb741142 730 Pfam PF13374 Tetratricopeptide repeat 99 138 0.0041 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS26720 91893d78e53a6f0f2212b27ccb741142 730 SUPERFAMILY SSF48452 50 204 8.54E-8 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS01230 be10ce42ccfca982f7c97d459d57c592 189 SUPERFAMILY SSF50814 27 182 3.52E-40 T 09-03-2017 IPR011038 Calycin-like TK78_RS01230 be10ce42ccfca982f7c97d459d57c592 189 Hamap MF_01297 UPF0678 fatty acid-binding protein-like protein . 22 184 31.2 T 09-03-2017 IPR022939 Uncharacterised protein family UPF0678 TK78_RS01230 be10ce42ccfca982f7c97d459d57c592 189 Pfam PF08768 Domain of unknown function (DUF1794) 30 182 9.1E-43 T 09-03-2017 IPR014878 Domain of unknown function DUF1794 TK78_RS22335 02462653209ae44827b0e762bc5ce45b 195 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 34 187 3.0E-25 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS22335 02462653209ae44827b0e762bc5ce45b 195 Gene3D G3DSA:1.10.10.10 131 190 7.3E-16 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS22335 02462653209ae44827b0e762bc5ce45b 195 ProSitePatterns PS01063 Sigma-70 factors ECF subfamily signature. 60 92 - T 09-03-2017 IPR000838 RNA polymerase sigma factor 70, ECF, conserved site GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS22335 02462653209ae44827b0e762bc5ce45b 195 Pfam PF04542 Sigma-70 region 2 37 105 2.4E-16 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS22335 02462653209ae44827b0e762bc5ce45b 195 SUPERFAMILY SSF88946 30 120 8.24E-21 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS22335 02462653209ae44827b0e762bc5ce45b 195 Gene3D G3DSA:1.10.1740.10 30 127 4.9E-22 T 09-03-2017 TK78_RS22335 02462653209ae44827b0e762bc5ce45b 195 Pfam PF04545 Sigma-70, region 4 137 185 1.4E-12 T 09-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS22335 02462653209ae44827b0e762bc5ce45b 195 SUPERFAMILY SSF88659 125 188 9.53E-13 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS14265 2c6f5e601eb11b80d0603e474533cb10 139 SUPERFAMILY SSF103196 1 131 2.09E-33 T 09-03-2017 TK78_RS14265 2c6f5e601eb11b80d0603e474533cb10 139 Pfam PF03259 Roadblock/LC7 domain 10 102 2.0E-21 T 09-03-2017 IPR004942 Roadblock/LAMTOR2 domain TK78_RS14265 2c6f5e601eb11b80d0603e474533cb10 139 Gene3D G3DSA:3.30.450.30 1 127 4.1E-30 T 09-03-2017 TK78_RS14265 2c6f5e601eb11b80d0603e474533cb10 139 SMART SM00960 10 102 1.4E-24 T 09-03-2017 IPR004942 Roadblock/LAMTOR2 domain TK78_RS15020 189827700ddbd93f60e13412cefce15b 283 TIGRFAM TIGR00685 T6PP: trehalose-phosphatase 29 280 3.5E-33 T 09-03-2017 IPR003337 Trehalose-phosphatase GO:0003824|GO:0005992 TK78_RS15020 189827700ddbd93f60e13412cefce15b 283 SUPERFAMILY SSF56784 31 280 3.61E-33 T 09-03-2017 IPR023214 HAD-like domain TK78_RS15020 189827700ddbd93f60e13412cefce15b 283 Gene3D G3DSA:3.40.50.1000 190 282 1.6E-33 T 09-03-2017 IPR023214 HAD-like domain TK78_RS15020 189827700ddbd93f60e13412cefce15b 283 Gene3D G3DSA:3.40.50.1000 30 110 1.6E-33 T 09-03-2017 IPR023214 HAD-like domain TK78_RS15020 189827700ddbd93f60e13412cefce15b 283 Pfam PF02358 Trehalose-phosphatase 34 237 6.3E-26 T 09-03-2017 IPR003337 Trehalose-phosphatase GO:0003824|GO:0005992 TK78_RS29285 5ca1ddabf08876533b482081a2a9d751 254 SMART SM00346 5 95 3.1E-34 T 09-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 TK78_RS29285 5ca1ddabf08876533b482081a2a9d751 254 Pfam PF01614 Bacterial transcriptional regulator 123 247 2.5E-32 T 09-03-2017 IPR014757 Transcription regulator IclR, C-terminal TK78_RS29285 5ca1ddabf08876533b482081a2a9d751 254 Pfam PF09339 IclR helix-turn-helix domain 7 57 1.5E-15 T 09-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 TK78_RS29285 5ca1ddabf08876533b482081a2a9d751 254 Gene3D G3DSA:3.30.450.40 75 250 6.1E-44 T 09-03-2017 IPR029016 GAF domain-like TK78_RS29285 5ca1ddabf08876533b482081a2a9d751 254 SUPERFAMILY SSF46785 5 77 6.02E-16 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS29285 5ca1ddabf08876533b482081a2a9d751 254 Gene3D G3DSA:1.10.10.10 3 74 5.5E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS29285 5ca1ddabf08876533b482081a2a9d751 254 SUPERFAMILY SSF55781 71 250 7.85E-37 T 09-03-2017 IPR029016 GAF domain-like TK78_RS03755 57a13c3baa797aecc9e13776f86fa908 236 Pfam PF00486 Transcriptional regulatory protein, C terminal 149 225 2.3E-22 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS03755 57a13c3baa797aecc9e13776f86fa908 236 Pfam PF00072 Response regulator receiver domain 1 110 3.4E-27 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS03755 57a13c3baa797aecc9e13776f86fa908 236 Gene3D G3DSA:3.40.50.2300 1 118 3.5E-37 T 09-03-2017 TK78_RS03755 57a13c3baa797aecc9e13776f86fa908 236 SUPERFAMILY SSF46894 126 226 4.42E-28 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS03755 57a13c3baa797aecc9e13776f86fa908 236 Gene3D G3DSA:1.10.10.10 127 228 8.3E-32 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS03755 57a13c3baa797aecc9e13776f86fa908 236 SMART SM00448 1 109 8.0E-35 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS03755 57a13c3baa797aecc9e13776f86fa908 236 SUPERFAMILY SSF52172 1 121 6.26E-38 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS03755 57a13c3baa797aecc9e13776f86fa908 236 SMART SM00862 149 225 6.1E-21 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS05780 d817b12b127caabe41b9c8f622233efb 153 Pfam PF13581 Histidine kinase-like ATPase domain 47 146 4.1E-8 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS05780 d817b12b127caabe41b9c8f622233efb 153 Gene3D G3DSA:3.30.565.10 38 151 6.2E-4 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS05780 d817b12b127caabe41b9c8f622233efb 153 SUPERFAMILY SSF55874 31 144 5.11E-5 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09680 d12fc538c76e7b9ed64b9e43a0bf9382 523 SUPERFAMILY SSF52540 100 382 3.93E-93 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09680 d12fc538c76e7b9ed64b9e43a0bf9382 523 Pfam PF00306 ATP synthase alpha/beta chain, C terminal domain 383 508 3.8E-47 T 09-03-2017 IPR000793 ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal GO:0015991|GO:0016820|GO:0033178 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 TK78_RS09680 d12fc538c76e7b9ed64b9e43a0bf9382 523 Hamap MF_01346 ATP synthase subunit alpha [atpA]. 4 513 48.694 T 09-03-2017 IPR005294 ATPase, F1 complex, alpha subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219|Reactome: R-HSA-1268020|Reactome: R-HSA-163210 TK78_RS09680 d12fc538c76e7b9ed64b9e43a0bf9382 523 TIGRFAM TIGR00962 atpA: ATP synthase F1, alpha subunit 6 512 1.1E-240 T 09-03-2017 IPR005294 ATPase, F1 complex, alpha subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219|Reactome: R-HSA-1268020|Reactome: R-HSA-163210 TK78_RS09680 d12fc538c76e7b9ed64b9e43a0bf9382 523 Gene3D G3DSA:2.40.30.20 5 97 1.2E-27 T 09-03-2017 IPR023366 ATP synthase subunit alpha-like domain KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219|Reactome: R-HSA-1268020|Reactome: R-HSA-163210 TK78_RS09680 d12fc538c76e7b9ed64b9e43a0bf9382 523 ProSitePatterns PS00152 ATP synthase alpha and beta subunits signature. 367 376 - T 09-03-2017 IPR020003 ATPase, alpha/beta subunit, nucleotide-binding domain, active site GO:0005524 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 TK78_RS09680 d12fc538c76e7b9ed64b9e43a0bf9382 523 SUPERFAMILY SSF50615 27 98 1.62E-21 T 09-03-2017 IPR004100 ATPase, F1 complex alpha/beta subunit, N-terminal domain GO:0015992|GO:0046034 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 TK78_RS09680 d12fc538c76e7b9ed64b9e43a0bf9382 523 Pfam PF02874 ATP synthase alpha/beta family, beta-barrel domain 30 96 1.0E-14 T 09-03-2017 IPR004100 ATPase, F1 complex alpha/beta subunit, N-terminal domain GO:0015992|GO:0046034 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 TK78_RS09680 d12fc538c76e7b9ed64b9e43a0bf9382 523 SUPERFAMILY SSF47917 384 512 1.83E-45 T 09-03-2017 IPR000793 ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal GO:0015991|GO:0016820|GO:0033178 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 TK78_RS09680 d12fc538c76e7b9ed64b9e43a0bf9382 523 Gene3D G3DSA:1.20.150.20 384 512 6.1E-52 T 09-03-2017 TK78_RS09680 d12fc538c76e7b9ed64b9e43a0bf9382 523 Gene3D G3DSA:3.40.50.300 99 383 5.2E-108 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09680 d12fc538c76e7b9ed64b9e43a0bf9382 523 Pfam PF00006 ATP synthase alpha/beta family, nucleotide-binding domain 153 376 2.7E-67 T 09-03-2017 IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain GO:0005524 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 TK78_RS09385 57ab538644b83b4d3542cd363e74b865 207 Gene3D G3DSA:1.10.260.40 58 119 1.2E-7 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS09385 57ab538644b83b4d3542cd363e74b865 207 SMART SM00530 5 52 35.0 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS09385 57ab538644b83b4d3542cd363e74b865 207 SMART SM00530 58 114 5.8E-6 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS09385 57ab538644b83b4d3542cd363e74b865 207 Pfam PF13560 Helix-turn-helix domain 55 113 5.5E-8 T 09-03-2017 TK78_RS09385 57ab538644b83b4d3542cd363e74b865 207 SUPERFAMILY SSF47413 56 119 1.81E-7 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS09385 57ab538644b83b4d3542cd363e74b865 207 Gene3D G3DSA:1.10.260.40 16 53 3.6E-5 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS24725 5802c81230fd016e0084b346512db3e1 493 Gene3D G3DSA:2.30.38.10 316 392 2.1E-27 T 09-03-2017 TK78_RS24725 5802c81230fd016e0084b346512db3e1 493 Gene3D G3DSA:3.40.50.980 155 315 4.8E-48 T 09-03-2017 TK78_RS24725 5802c81230fd016e0084b346512db3e1 493 Gene3D G3DSA:3.40.50.980 5 154 2.7E-42 T 09-03-2017 TK78_RS24725 5802c81230fd016e0084b346512db3e1 493 ProSitePatterns PS00455 Putative AMP-binding domain signature. 149 160 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS24725 5802c81230fd016e0084b346512db3e1 493 Gene3D G3DSA:3.30.300.30 393 491 5.5E-32 T 09-03-2017 TK78_RS24725 5802c81230fd016e0084b346512db3e1 493 Pfam PF00501 AMP-binding enzyme 9 398 1.2E-114 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS24725 5802c81230fd016e0084b346512db3e1 493 SUPERFAMILY SSF56801 4 491 3.01E-160 T 09-03-2017 TK78_RS24725 5802c81230fd016e0084b346512db3e1 493 Pfam PF13193 AMP-binding enzyme C-terminal domain 407 482 1.2E-17 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS13125 8e51b787665450fcacf182d8b04ef4cb 74 Gene3D G3DSA:1.10.287.310 6 69 1.2E-31 T 09-03-2017 IPR001854 Ribosomal protein L29 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13125 8e51b787665450fcacf182d8b04ef4cb 74 TIGRFAM TIGR00012 L29: ribosomal protein uL29 9 64 1.8E-22 T 09-03-2017 IPR001854 Ribosomal protein L29 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13125 8e51b787665450fcacf182d8b04ef4cb 74 Pfam PF00831 Ribosomal L29 protein 8 64 2.2E-26 T 09-03-2017 IPR001854 Ribosomal protein L29 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13125 8e51b787665450fcacf182d8b04ef4cb 74 Hamap MF_00374 50S ribosomal protein L29 [rpmC]. 5 64 18.184 T 09-03-2017 IPR001854 Ribosomal protein L29 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13125 8e51b787665450fcacf182d8b04ef4cb 74 ProSitePatterns PS00579 Ribosomal protein L29 signature. 43 57 - T 09-03-2017 IPR018254 Ribosomal protein L29, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13125 8e51b787665450fcacf182d8b04ef4cb 74 SUPERFAMILY SSF46561 5 67 2.22E-24 T 09-03-2017 IPR001854 Ribosomal protein L29 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS10435 00c597e83267d655451623fdc1975630 277 Pfam PF01177 Asp/Glu/Hydantoin racemase 8 216 8.9E-35 T 09-03-2017 IPR015942 Asp/Glu/hydantoin racemase GO:0006807|GO:0036361 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS10435 00c597e83267d655451623fdc1975630 277 TIGRFAM TIGR00067 glut_race: glutamate racemase 8 254 2.6E-62 T 09-03-2017 IPR004391 Glutamate racemase GO:0008881|GO:0009252 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS10435 00c597e83267d655451623fdc1975630 277 Gene3D G3DSA:3.40.50.1860 6 174 1.7E-49 T 09-03-2017 IPR001920 Asp/Glu racemase GO:0008152|GO:0016855 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS10435 00c597e83267d655451623fdc1975630 277 ProSitePatterns PS00924 Aspartate and glutamate racemases signature 2. 181 191 - T 09-03-2017 IPR033134 Asp/Glu racemase, active site 2 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS10435 00c597e83267d655451623fdc1975630 277 ProSitePatterns PS00923 Aspartate and glutamate racemases signature 1. 72 80 - T 09-03-2017 IPR018187 Asp/Glu racemase, active site 1 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS10435 00c597e83267d655451623fdc1975630 277 Hamap MF_00258 Glutamate racemase [murI]. 6 258 34.967 T 09-03-2017 IPR004391 Glutamate racemase GO:0008881|GO:0009252 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS10435 00c597e83267d655451623fdc1975630 277 SUPERFAMILY SSF53681 111 259 2.29E-34 T 09-03-2017 IPR001920 Asp/Glu racemase GO:0008152|GO:0016855 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS10435 00c597e83267d655451623fdc1975630 277 SUPERFAMILY SSF53681 7 109 1.5E-33 T 09-03-2017 IPR001920 Asp/Glu racemase GO:0008152|GO:0016855 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS26480 b0b88f38d543518ea6c2f43bd1fc5ce6 515 SMART SM00345 30 89 7.2E-17 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS26480 b0b88f38d543518ea6c2f43bd1fc5ce6 515 SUPERFAMILY SSF46785 22 93 7.42E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS26480 b0b88f38d543518ea6c2f43bd1fc5ce6 515 SUPERFAMILY SSF53383 107 440 4.74E-64 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS26480 b0b88f38d543518ea6c2f43bd1fc5ce6 515 Gene3D G3DSA:3.40.640.10 149 356 2.8E-39 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS26480 b0b88f38d543518ea6c2f43bd1fc5ce6 515 Pfam PF00155 Aminotransferase class I and II 128 411 1.3E-12 T 09-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TK78_RS26480 b0b88f38d543518ea6c2f43bd1fc5ce6 515 Gene3D G3DSA:1.10.10.10 30 93 1.3E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS26480 b0b88f38d543518ea6c2f43bd1fc5ce6 515 Pfam PF00392 Bacterial regulatory proteins, gntR family 32 89 1.3E-16 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS31465 67470a743d65793cff18a21bf92b75ec 516 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 102 118 3.9E-6 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS31465 67470a743d65793cff18a21bf92b75ec 516 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 88 102 3.9E-6 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS31465 67470a743d65793cff18a21bf92b75ec 516 Gene3D G3DSA:1.10.10.10 68 130 1.3E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS31465 67470a743d65793cff18a21bf92b75ec 516 SUPERFAMILY SSF53383 150 507 9.19E-81 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS31465 67470a743d65793cff18a21bf92b75ec 516 Gene3D G3DSA:3.40.640.10 185 397 7.1E-50 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS31465 67470a743d65793cff18a21bf92b75ec 516 Pfam PF00392 Bacterial regulatory proteins, gntR family 70 128 4.1E-13 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS31465 67470a743d65793cff18a21bf92b75ec 516 SUPERFAMILY SSF46785 67 130 9.53E-16 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS31465 67470a743d65793cff18a21bf92b75ec 516 SMART SM00345 69 128 8.5E-12 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS31465 67470a743d65793cff18a21bf92b75ec 516 Pfam PF00155 Aminotransferase class I and II 180 437 1.2E-15 T 09-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TK78_RS22385 190abea38406ca63066e9f16534c5910 434 Pfam PF13416 Bacterial extracellular solute-binding protein 62 370 9.3E-36 T 09-03-2017 TK78_RS22385 190abea38406ca63066e9f16534c5910 434 SUPERFAMILY SSF53850 41 427 7.41E-77 T 09-03-2017 TK78_RS22385 190abea38406ca63066e9f16534c5910 434 Gene3D G3DSA:3.40.190.10 41 173 3.8E-18 T 09-03-2017 TK78_RS22385 190abea38406ca63066e9f16534c5910 434 Gene3D G3DSA:3.40.190.10 174 363 1.6E-45 T 09-03-2017 TK78_RS15140 ed0ad5dfaba768e9b8a625738048dd58 260 Pfam PF01255 Putative undecaprenyl diphosphate synthase 36 259 7.0E-64 T 09-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TK78_RS15140 ed0ad5dfaba768e9b8a625738048dd58 260 ProSitePatterns PS01066 Undecaprenyl pyrophosphate synthase family signature. 205 222 - T 09-03-2017 IPR018520 Di-trans-poly-cis-decaprenylcistransferase-like, conserved site GO:0016765 Reactome: R-HSA-446199|Reactome: R-HSA-4755609 TK78_RS15140 ed0ad5dfaba768e9b8a625738048dd58 260 Gene3D G3DSA:3.40.1180.10 15 260 8.1E-73 T 09-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TK78_RS15140 ed0ad5dfaba768e9b8a625738048dd58 260 Hamap MF_01139 Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) [uppS]. 28 260 33.41 T 09-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TK78_RS15140 ed0ad5dfaba768e9b8a625738048dd58 260 TIGRFAM TIGR00055 uppS: di-trans,poly-cis-decaprenylcistransferase 29 259 2.0E-57 T 09-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TK78_RS15140 ed0ad5dfaba768e9b8a625738048dd58 260 SUPERFAMILY SSF64005 27 254 9.42E-63 T 09-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TK78_RS12610 a91d95fa1ddb09b2bac603acfbfa0561 449 Pfam PF09922 Cell wall-active antibiotics response 4TMS YvqF 345 444 2.5E-8 T 09-03-2017 IPR024425 Cell wall-active antibiotics response 4TMS YvqF TK78_RS12610 a91d95fa1ddb09b2bac603acfbfa0561 449 Pfam PF04024 PspC domain 21 75 1.8E-15 T 09-03-2017 IPR007168 Phage shock protein, PspC, N-terminal TK78_RS15310 cc9163ba4f9a8b0c1398f5c380bbca53 809 PIRSF PIRSF001265 30 757 5.9E-261 T 09-03-2017 IPR004131 Pyrophosphate-energised proton pump GO:0004427|GO:0009678|GO:0015992|GO:0016020 KEGG: 00190+3.6.1.1 TK78_RS15310 cc9163ba4f9a8b0c1398f5c380bbca53 809 Pfam PF03030 Inorganic H+ pyrophosphatase 46 744 2.4E-237 T 09-03-2017 IPR004131 Pyrophosphate-energised proton pump GO:0004427|GO:0009678|GO:0015992|GO:0016020 KEGG: 00190+3.6.1.1 TK78_RS15310 cc9163ba4f9a8b0c1398f5c380bbca53 809 TIGRFAM TIGR01104 V_PPase: V-type H(+)-translocating pyrophosphatase 38 750 1.2E-203 T 09-03-2017 IPR004131 Pyrophosphate-energised proton pump GO:0004427|GO:0009678|GO:0015992|GO:0016020 KEGG: 00190+3.6.1.1 TK78_RS15310 cc9163ba4f9a8b0c1398f5c380bbca53 809 Hamap MF_01129 Putative K(+)-stimulated pyrophosphate-energized sodium pump [hppA]. 35 749 24.575 T 09-03-2017 IPR004131 Pyrophosphate-energised proton pump GO:0004427|GO:0009678|GO:0015992|GO:0016020 KEGG: 00190+3.6.1.1 TK78_RS15060 310eec703ac8cb5400fa670c8a20840d 344 SUPERFAMILY SSF51735 148 311 3.13E-35 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS15060 310eec703ac8cb5400fa670c8a20840d 344 Gene3D G3DSA:3.90.180.10 2 169 4.6E-40 T 09-03-2017 IPR011032 GroES-like TK78_RS15060 310eec703ac8cb5400fa670c8a20840d 344 Gene3D G3DSA:3.40.50.720 170 289 1.3E-32 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS15060 310eec703ac8cb5400fa670c8a20840d 344 Pfam PF00107 Zinc-binding dehydrogenase 178 305 6.2E-21 T 09-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 TK78_RS15060 310eec703ac8cb5400fa670c8a20840d 344 SUPERFAMILY SSF50129 2 166 8.33E-48 T 09-03-2017 IPR011032 GroES-like TK78_RS15060 310eec703ac8cb5400fa670c8a20840d 344 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 26 127 2.9E-25 T 09-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 TK78_RS24775 ae938450e68e9e89535219653b7070ca 357 Pfam PF03060 Nitronate monooxygenase 3 342 3.9E-112 T 09-03-2017 IPR004136 Nitronate monooxygenase GO:0018580|GO:0055114 KEGG: 00910+1.13.12.16|MetaCyc: PWY-723 TK78_RS24775 ae938450e68e9e89535219653b7070ca 357 SUPERFAMILY SSF51412 5 348 2.14E-61 T 09-03-2017 TK78_RS24775 ae938450e68e9e89535219653b7070ca 357 Gene3D G3DSA:3.20.20.70 1 335 3.3E-68 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS33275 181918467fff76b6c3e0e43a4aba5955 290 Pfam PF01497 Periplasmic binding protein 61 240 1.0E-7 T 09-03-2017 IPR002491 ABC transporter periplasmic binding domain GO:0005488 TK78_RS33275 181918467fff76b6c3e0e43a4aba5955 290 SUPERFAMILY SSF53807 9 249 1.18E-18 T 09-03-2017 TK78_RS33275 181918467fff76b6c3e0e43a4aba5955 290 Gene3D G3DSA:3.40.50.1980 9 143 1.7E-10 T 09-03-2017 TK78_RS21325 7ee5dc9cd02626caa88602b509e4dc1f 228 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 38 51 7.7E-10 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS21325 7ee5dc9cd02626caa88602b509e4dc1f 228 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 59 82 7.7E-10 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS21325 7ee5dc9cd02626caa88602b509e4dc1f 228 ProSitePatterns PS01081 TetR-type HTH domain signature. 50 80 - T 09-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site TK78_RS21325 7ee5dc9cd02626caa88602b509e4dc1f 228 Gene3D G3DSA:1.10.357.10 20 213 4.1E-48 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS21325 7ee5dc9cd02626caa88602b509e4dc1f 228 SUPERFAMILY SSF46689 24 104 1.8E-21 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS21325 7ee5dc9cd02626caa88602b509e4dc1f 228 SUPERFAMILY SSF48498 105 215 8.54E-7 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS21325 7ee5dc9cd02626caa88602b509e4dc1f 228 Pfam PF00440 Bacterial regulatory proteins, tetR family 38 82 2.8E-17 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS04125 f3fb819ce898aac3507fbfa76ac27abc 320 SUPERFAMILY SSF141986 156 305 2.88E-33 T 09-03-2017 IPR027461 LD-carboxypeptidase A, C-terminal domain TK78_RS04125 f3fb819ce898aac3507fbfa76ac27abc 320 Pfam PF02016 LD-carboxypeptidase 24 300 3.5E-72 T 09-03-2017 IPR003507 Peptidase family S66 TK78_RS04125 f3fb819ce898aac3507fbfa76ac27abc 320 Gene3D G3DSA:3.50.30.60 182 304 1.7E-31 T 09-03-2017 IPR027461 LD-carboxypeptidase A, C-terminal domain TK78_RS04125 f3fb819ce898aac3507fbfa76ac27abc 320 SUPERFAMILY SSF52317 12 174 6.87E-48 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS04125 f3fb819ce898aac3507fbfa76ac27abc 320 PIRSF PIRSF028757 12 312 3.3E-66 T 09-03-2017 IPR003507 Peptidase family S66 TK78_RS04125 f3fb819ce898aac3507fbfa76ac27abc 320 Gene3D G3DSA:3.40.50.10740 11 171 1.6E-54 T 09-03-2017 IPR027478 Murein tetrapeptide carboxypeptidase, N-terminal domain TK78_RS23950 9d8dc64162015baffc60965442ad2d09 500 Gene3D G3DSA:3.40.605.10 4 261 3.7E-89 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS23950 9d8dc64162015baffc60965442ad2d09 500 Gene3D G3DSA:3.40.309.10 262 443 4.6E-63 T 09-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 TK78_RS23950 9d8dc64162015baffc60965442ad2d09 500 Pfam PF00171 Aldehyde dehydrogenase family 17 476 6.0E-135 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS23950 9d8dc64162015baffc60965442ad2d09 500 SUPERFAMILY SSF53720 2 484 5.89E-144 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS23950 9d8dc64162015baffc60965442ad2d09 500 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 275 286 - T 09-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 TK78_RS23950 9d8dc64162015baffc60965442ad2d09 500 TIGRFAM TIGR01722 MMSDH: methylmalonate-semialdehyde dehydrogenase (acylating) 5 482 4.6E-249 T 09-03-2017 IPR010061 Methylmalonate-semialdehyde dehydrogenase GO:0004491|GO:0055114 KEGG: 00280+1.2.1.27|KEGG: 00410+1.2.1.18|KEGG: 00562+1.2.1.18|KEGG: 00640+1.2.1.18+1.2.1.27|MetaCyc: PWY-5642|MetaCyc: PWY-6373|Reactome: R-HSA-70895 TK78_RS15965 a117a8615549fbfb4f287fc686e85a9c 408 SUPERFAMILY SSF53383 14 403 4.94E-78 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS15965 a117a8615549fbfb4f287fc686e85a9c 408 TIGRFAM TIGR01814 kynureninase: kynureninase 18 402 3.6E-80 T 09-03-2017 IPR010111 Kynureninase GO:0005737|GO:0006569|GO:0009435|GO:0030170|GO:0030429 KEGG: 00380+3.7.1.3|MetaCyc: PWY-5651|MetaCyc: PWY-6309|Reactome: R-HSA-71240 TK78_RS15965 a117a8615549fbfb4f287fc686e85a9c 408 Gene3D G3DSA:3.90.1150.10 263 405 2.9E-47 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS15965 a117a8615549fbfb4f287fc686e85a9c 408 Hamap MF_01970 Kynureninase [kynU]. 2 402 33.931 T 09-03-2017 IPR010111 Kynureninase GO:0005737|GO:0006569|GO:0009435|GO:0030170|GO:0030429 KEGG: 00380+3.7.1.3|MetaCyc: PWY-5651|MetaCyc: PWY-6309|Reactome: R-HSA-71240 TK78_RS15965 a117a8615549fbfb4f287fc686e85a9c 408 PIRSF PIRSF038800 9 408 1.5E-131 T 09-03-2017 IPR010111 Kynureninase GO:0005737|GO:0006569|GO:0009435|GO:0030170|GO:0030429 KEGG: 00380+3.7.1.3|MetaCyc: PWY-5651|MetaCyc: PWY-6309|Reactome: R-HSA-71240 TK78_RS15965 a117a8615549fbfb4f287fc686e85a9c 408 Pfam PF00266 Aminotransferase class-V 40 333 2.9E-15 T 09-03-2017 IPR000192 Aminotransferase class V domain TK78_RS15965 a117a8615549fbfb4f287fc686e85a9c 408 Gene3D G3DSA:3.40.640.10 85 262 2.8E-21 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS31130 5bcf580cd3db7991261a7bfbd983f1fc 415 SUPERFAMILY SSF56059 105 315 2.47E-35 T 09-03-2017 TK78_RS31130 5bcf580cd3db7991261a7bfbd983f1fc 415 Pfam PF13535 ATP-grasp domain 148 285 4.3E-18 T 09-03-2017 TK78_RS31130 5bcf580cd3db7991261a7bfbd983f1fc 415 Gene3D G3DSA:3.30.470.20 106 395 1.0E-26 T 09-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 TK78_RS21490 f0e74d70cea3f7211ae8395242e32a71 330 SMART SM00829 14 323 2.8E-34 T 09-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 TK78_RS21490 f0e74d70cea3f7211ae8395242e32a71 330 Gene3D G3DSA:3.90.180.10 4 153 4.6E-45 T 09-03-2017 IPR011032 GroES-like TK78_RS21490 f0e74d70cea3f7211ae8395242e32a71 330 SUPERFAMILY SSF50129 2 154 8.98E-38 T 09-03-2017 IPR011032 GroES-like TK78_RS21490 f0e74d70cea3f7211ae8395242e32a71 330 Pfam PF13602 Zinc-binding dehydrogenase 191 309 1.3E-22 T 09-03-2017 TK78_RS21490 f0e74d70cea3f7211ae8395242e32a71 330 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 32 93 7.6E-9 T 09-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 TK78_RS21490 f0e74d70cea3f7211ae8395242e32a71 330 Gene3D G3DSA:3.40.50.720 154 242 1.3E-22 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS21490 f0e74d70cea3f7211ae8395242e32a71 330 SUPERFAMILY SSF51735 121 281 1.52E-37 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS32635 205098d99f116ed0d95163bd3ad15a2b 479 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 3 193 4.1E-8 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS32635 205098d99f116ed0d95163bd3ad15a2b 479 SUPERFAMILY SSF51971 303 465 3.59E-5 T 09-03-2017 TK78_RS32635 205098d99f116ed0d95163bd3ad15a2b 479 Gene3D G3DSA:3.50.50.60 98 347 3.4E-61 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS32635 205098d99f116ed0d95163bd3ad15a2b 479 Gene3D G3DSA:3.40.50.720 2 97 5.1E-65 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS32635 205098d99f116ed0d95163bd3ad15a2b 479 Gene3D G3DSA:3.40.50.720 348 472 5.1E-65 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS32635 205098d99f116ed0d95163bd3ad15a2b 479 SUPERFAMILY SSF51971 3 216 1.04E-48 T 09-03-2017 TK78_RS32635 205098d99f116ed0d95163bd3ad15a2b 479 SUPERFAMILY SSF51971 291 348 1.04E-48 T 09-03-2017 TK78_RS32635 205098d99f116ed0d95163bd3ad15a2b 479 PRINTS PR00419 Adrenodoxin reductase family signature 217 230 3.0E-14 T 09-03-2017 TK78_RS32635 205098d99f116ed0d95163bd3ad15a2b 479 PRINTS PR00419 Adrenodoxin reductase family signature 150 164 3.0E-14 T 09-03-2017 TK78_RS32635 205098d99f116ed0d95163bd3ad15a2b 479 PRINTS PR00419 Adrenodoxin reductase family signature 3 25 3.0E-14 T 09-03-2017 TK78_RS32635 205098d99f116ed0d95163bd3ad15a2b 479 PIRSF PIRSF000362 1 477 1.1E-137 T 09-03-2017 IPR021163 Ferredoxin-NADP+ reductase, adrenodoxin-type GO:0016491|GO:0055114 Reactome: R-HSA-196108|Reactome: R-HSA-211976|Reactome: R-HSA-2395516|Reactome: R-HSA-5579026 TK78_RS33115 09ef75ac466e7f065bad90950bb68a21 1125 SUPERFAMILY SSF49303 531 625 1.96E-14 T 09-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 TK78_RS33115 09ef75ac466e7f065bad90950bb68a21 1125 Gene3D G3DSA:2.60.120.260 344 518 6.4E-52 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS33115 09ef75ac466e7f065bad90950bb68a21 1125 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 668 779 1.8E-4 T 09-03-2017 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 TK78_RS33115 09ef75ac466e7f065bad90950bb68a21 1125 Gene3D G3DSA:2.60.40.320 519 622 2.9E-21 T 09-03-2017 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 TK78_RS33115 09ef75ac466e7f065bad90950bb68a21 1125 Gene3D G3DSA:3.90.182.10 71 247 1.6E-42 T 09-03-2017 IPR011658 PA14 domain TK78_RS33115 09ef75ac466e7f065bad90950bb68a21 1125 SMART SM00560 984 1114 8.4E-15 T 09-03-2017 IPR006558 LamG-like jellyroll fold TK78_RS33115 09ef75ac466e7f065bad90950bb68a21 1125 Gene3D G3DSA:3.20.20.80 623 908 1.1E-41 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS33115 09ef75ac466e7f065bad90950bb68a21 1125 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 361 491 2.3E-9 T 09-03-2017 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 TK78_RS33115 09ef75ac466e7f065bad90950bb68a21 1125 SUPERFAMILY SSF56988 80 235 1.7E-39 T 09-03-2017 TK78_RS33115 09ef75ac466e7f065bad90950bb68a21 1125 SUPERFAMILY SSF51445 621 903 5.19E-53 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS33115 09ef75ac466e7f065bad90950bb68a21 1125 SMART SM00758 78 220 2.5E-27 T 09-03-2017 IPR011658 PA14 domain TK78_RS33115 09ef75ac466e7f065bad90950bb68a21 1125 Pfam PF13385 Concanavalin A-like lectin/glucanases superfamily 967 1117 7.6E-29 T 09-03-2017 TK78_RS33115 09ef75ac466e7f065bad90950bb68a21 1125 SUPERFAMILY SSF49899 926 1122 9.4E-37 T 09-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain TK78_RS33115 09ef75ac466e7f065bad90950bb68a21 1125 Gene3D G3DSA:2.60.120.200 925 1120 6.5E-37 T 09-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain TK78_RS33115 09ef75ac466e7f065bad90950bb68a21 1125 SUPERFAMILY SSF49785 344 527 4.25E-40 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS33115 09ef75ac466e7f065bad90950bb68a21 1125 Pfam PF00703 Glycosyl hydrolases family 2 531 624 1.9E-13 T 09-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 TK78_RS33115 09ef75ac466e7f065bad90950bb68a21 1125 Pfam PF07691 PA14 domain 81 219 1.9E-22 T 09-03-2017 IPR011658 PA14 domain TK78_RS07290 6b6801c64312ad976b6edfabbf06ace3 723 TIGRFAM TIGR00614 recQ_fam: ATP-dependent DNA helicase, RecQ family 29 363 9.3E-68 T 09-03-2017 IPR004589 DNA helicase, ATP-dependent, RecQ type GO:0006310|GO:0008026 TK78_RS07290 6b6801c64312ad976b6edfabbf06ace3 723 Gene3D G3DSA:3.40.50.300 26 209 6.8E-36 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07290 6b6801c64312ad976b6edfabbf06ace3 723 SMART SM00487 26 228 1.6E-20 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS07290 6b6801c64312ad976b6edfabbf06ace3 723 Gene3D G3DSA:3.40.50.2020 642 719 8.6E-7 T 09-03-2017 IPR029057 Phosphoribosyltransferase-like TK78_RS07290 6b6801c64312ad976b6edfabbf06ace3 723 Pfam PF00271 Helicase conserved C-terminal domain 254 347 1.3E-12 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS07290 6b6801c64312ad976b6edfabbf06ace3 723 Pfam PF00270 DEAD/DEAH box helicase 33 199 8.3E-15 T 09-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 TK78_RS07290 6b6801c64312ad976b6edfabbf06ace3 723 Gene3D G3DSA:3.40.50.300 222 370 6.5E-28 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07290 6b6801c64312ad976b6edfabbf06ace3 723 Gene3D G3DSA:1.10.10.10 446 502 1.2E-8 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS07290 6b6801c64312ad976b6edfabbf06ace3 723 SUPERFAMILY SSF53271 682 720 1.44E-8 T 09-03-2017 IPR029057 Phosphoribosyltransferase-like TK78_RS07290 6b6801c64312ad976b6edfabbf06ace3 723 SMART SM00490 267 348 8.7E-22 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS07290 6b6801c64312ad976b6edfabbf06ace3 723 SUPERFAMILY SSF52540 38 357 6.92E-49 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS34195 e09730261045ede4abf32348e515e137 86 Pfam PF01197 Ribosomal protein L31 1 79 7.2E-26 T 09-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS34195 e09730261045ede4abf32348e515e137 86 ProSitePatterns PS01143 Ribosomal protein L31 signature. 49 70 - T 09-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS34195 e09730261045ede4abf32348e515e137 86 TIGRFAM TIGR00105 L31: ribosomal protein bL31 1 80 2.0E-15 T 09-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS34195 e09730261045ede4abf32348e515e137 86 SUPERFAMILY SSF143800 1 79 3.26E-19 T 09-03-2017 TK78_RS34195 e09730261045ede4abf32348e515e137 86 PRINTS PR01249 Ribosomal protein L31 signature 60 78 1.6E-14 T 09-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS34195 e09730261045ede4abf32348e515e137 86 PRINTS PR01249 Ribosomal protein L31 signature 45 60 1.6E-14 T 09-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS34195 e09730261045ede4abf32348e515e137 86 PRINTS PR01249 Ribosomal protein L31 signature 2 19 1.6E-14 T 09-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS19465 db2bbd59786390b368aedc3651874125 425 Pfam PF13416 Bacterial extracellular solute-binding protein 62 360 2.2E-37 T 09-03-2017 TK78_RS19465 db2bbd59786390b368aedc3651874125 425 Gene3D G3DSA:3.40.190.10 167 353 4.8E-36 T 09-03-2017 TK78_RS19465 db2bbd59786390b368aedc3651874125 425 Gene3D G3DSA:3.40.190.10 54 166 1.6E-20 T 09-03-2017 TK78_RS19465 db2bbd59786390b368aedc3651874125 425 SUPERFAMILY SSF53850 52 417 2.95E-60 T 09-03-2017 TK78_RS16610 c26749c6f476d446e737d10f1e4d0a35 843 Pfam PF13620 Carboxypeptidase regulatory-like domain 593 663 3.2E-11 T 09-03-2017 TK78_RS16610 c26749c6f476d446e737d10f1e4d0a35 843 Pfam PF13620 Carboxypeptidase regulatory-like domain 761 838 9.8E-10 T 09-03-2017 TK78_RS16610 c26749c6f476d446e737d10f1e4d0a35 843 Pfam PF13620 Carboxypeptidase regulatory-like domain 676 755 4.7E-11 T 09-03-2017 TK78_RS16610 c26749c6f476d446e737d10f1e4d0a35 843 PRINTS PR01036 Tetracycline resistance protein TetB signature 432 451 7.9E-10 T 09-03-2017 TK78_RS16610 c26749c6f476d446e737d10f1e4d0a35 843 PRINTS PR01036 Tetracycline resistance protein TetB signature 165 189 7.9E-10 T 09-03-2017 TK78_RS16610 c26749c6f476d446e737d10f1e4d0a35 843 PRINTS PR01036 Tetracycline resistance protein TetB signature 44 68 7.9E-10 T 09-03-2017 TK78_RS16610 c26749c6f476d446e737d10f1e4d0a35 843 PRINTS PR01036 Tetracycline resistance protein TetB signature 135 155 7.9E-10 T 09-03-2017 TK78_RS16610 c26749c6f476d446e737d10f1e4d0a35 843 Gene3D G3DSA:2.60.40.10 762 814 4.2E-11 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS16610 c26749c6f476d446e737d10f1e4d0a35 843 Gene3D G3DSA:2.60.40.1120 675 755 4.0E-11 T 09-03-2017 IPR014766 Carboxypeptidase, regulatory domain TK78_RS16610 c26749c6f476d446e737d10f1e4d0a35 843 SUPERFAMILY SSF49464 593 670 2.86E-10 T 09-03-2017 IPR008969 Carboxypeptidase-like, regulatory domain TK78_RS16610 c26749c6f476d446e737d10f1e4d0a35 843 SUPERFAMILY SSF49478 761 828 3.1E-11 T 09-03-2017 TK78_RS16610 c26749c6f476d446e737d10f1e4d0a35 843 Gene3D G3DSA:1.20.1250.20 502 530 4.5E-25 T 09-03-2017 TK78_RS16610 c26749c6f476d446e737d10f1e4d0a35 843 Gene3D G3DSA:1.20.1250.20 285 456 4.5E-25 T 09-03-2017 TK78_RS16610 c26749c6f476d446e737d10f1e4d0a35 843 Gene3D G3DSA:1.20.1250.20 43 215 1.6E-28 T 09-03-2017 TK78_RS16610 c26749c6f476d446e737d10f1e4d0a35 843 SUPERFAMILY SSF103473 501 525 2.35E-66 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS16610 c26749c6f476d446e737d10f1e4d0a35 843 SUPERFAMILY SSF103473 32 225 2.35E-66 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS16610 c26749c6f476d446e737d10f1e4d0a35 843 SUPERFAMILY SSF103473 279 451 2.35E-66 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS16610 c26749c6f476d446e737d10f1e4d0a35 843 SUPERFAMILY SSF49464 675 766 1.96E-10 T 09-03-2017 IPR008969 Carboxypeptidase-like, regulatory domain TK78_RS16610 c26749c6f476d446e737d10f1e4d0a35 843 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 41 456 1.2E-69 T 09-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 TK78_RS16610 c26749c6f476d446e737d10f1e4d0a35 843 Gene3D G3DSA:2.60.40.1120 593 663 2.7E-9 T 09-03-2017 IPR014766 Carboxypeptidase, regulatory domain TK78_RS16610 c26749c6f476d446e737d10f1e4d0a35 843 Pfam PF07690 Major Facilitator Superfamily 45 441 1.1E-47 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS25585 53f970fc2ea044d7f51f48638f14cb36 539 Gene3D G3DSA:1.20.1250.20 27 216 9.3E-33 T 09-03-2017 TK78_RS25585 53f970fc2ea044d7f51f48638f14cb36 539 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 33 445 2.3E-80 T 09-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 TK78_RS25585 53f970fc2ea044d7f51f48638f14cb36 539 Gene3D G3DSA:1.20.1250.20 290 441 4.2E-20 T 09-03-2017 TK78_RS25585 53f970fc2ea044d7f51f48638f14cb36 539 Gene3D G3DSA:1.20.1250.20 502 526 4.2E-20 T 09-03-2017 TK78_RS25585 53f970fc2ea044d7f51f48638f14cb36 539 PRINTS PR01035 Tetracycline resistance protein signature 362 385 3.6E-5 T 09-03-2017 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 TK78_RS25585 53f970fc2ea044d7f51f48638f14cb36 539 PRINTS PR01035 Tetracycline resistance protein signature 34 50 3.6E-5 T 09-03-2017 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 TK78_RS25585 53f970fc2ea044d7f51f48638f14cb36 539 PRINTS PR01035 Tetracycline resistance protein signature 158 180 3.6E-5 T 09-03-2017 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 TK78_RS25585 53f970fc2ea044d7f51f48638f14cb36 539 SUPERFAMILY SSF103473 501 526 3.53E-71 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS25585 53f970fc2ea044d7f51f48638f14cb36 539 SUPERFAMILY SSF103473 8 216 3.53E-71 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS25585 53f970fc2ea044d7f51f48638f14cb36 539 SUPERFAMILY SSF103473 269 440 3.53E-71 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS25585 53f970fc2ea044d7f51f48638f14cb36 539 Pfam PF07690 Major Facilitator Superfamily 37 430 7.1E-50 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS17075 1b7ae76f97eab14cf92c980c647d64f5 333 PIRSF PIRSF000267 1 333 7.5E-123 T 09-03-2017 IPR003317 Cytochrome ubiquinol oxidase subunit 2 GO:0016020|GO:0055114 TK78_RS17075 1b7ae76f97eab14cf92c980c647d64f5 333 TIGRFAM TIGR00203 cydB: cytochrome d ubiquinol oxidase, subunit II 3 217 2.1E-78 T 09-03-2017 IPR003317 Cytochrome ubiquinol oxidase subunit 2 GO:0016020|GO:0055114 TK78_RS17075 1b7ae76f97eab14cf92c980c647d64f5 333 Pfam PF02322 Cytochrome bd terminal oxidase subunit II 3 320 2.9E-116 T 09-03-2017 IPR003317 Cytochrome ubiquinol oxidase subunit 2 GO:0016020|GO:0055114 TK78_RS01370 ce719c486f0a3ad96383dfff0a71b882 159 SUPERFAMILY SSF69118 21 151 3.84E-31 T 09-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 TK78_RS01370 ce719c486f0a3ad96383dfff0a71b882 159 Pfam PF02627 Carboxymuconolactone decarboxylase family 27 102 8.3E-7 T 09-03-2017 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 TK78_RS01370 ce719c486f0a3ad96383dfff0a71b882 159 Gene3D G3DSA:1.20.1290.10 21 151 4.9E-37 T 09-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 TK78_RS31800 f94243505ab145a30cf8ac9cf1e033be 375 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 10 32 6.8E-14 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS31800 f94243505ab145a30cf8ac9cf1e033be 375 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 131 139 6.8E-14 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS31800 f94243505ab145a30cf8ac9cf1e033be 375 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 170 194 6.8E-14 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS31800 f94243505ab145a30cf8ac9cf1e033be 375 Pfam PF13738 Pyridine nucleotide-disulphide oxidoreductase 12 210 5.2E-24 T 09-03-2017 TK78_RS31800 f94243505ab145a30cf8ac9cf1e033be 375 Gene3D G3DSA:3.50.50.60 257 281 3.2E-25 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS31800 f94243505ab145a30cf8ac9cf1e033be 375 Gene3D G3DSA:3.50.50.60 156 211 3.2E-25 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS31800 f94243505ab145a30cf8ac9cf1e033be 375 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 11 30 8.6E-11 T 09-03-2017 TK78_RS31800 f94243505ab145a30cf8ac9cf1e033be 375 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 174 192 8.6E-11 T 09-03-2017 TK78_RS31800 f94243505ab145a30cf8ac9cf1e033be 375 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 283 299 8.6E-11 T 09-03-2017 TK78_RS31800 f94243505ab145a30cf8ac9cf1e033be 375 Gene3D G3DSA:3.50.50.60 282 355 1.5E-5 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS31800 f94243505ab145a30cf8ac9cf1e033be 375 Gene3D G3DSA:3.50.50.60 8 155 4.1E-22 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS31800 f94243505ab145a30cf8ac9cf1e033be 375 SUPERFAMILY SSF51905 9 213 1.57E-41 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS31800 f94243505ab145a30cf8ac9cf1e033be 375 SUPERFAMILY SSF51905 172 208 8.29E-10 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS31800 f94243505ab145a30cf8ac9cf1e033be 375 SUPERFAMILY SSF51905 239 354 8.29E-10 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS30215 4a7104b394f77f87ca30037c860d9b49 204 ProSitePatterns PS00632 Ribosomal protein S4 signature. 90 114 - T 09-03-2017 IPR018079 Ribosomal protein S4, conserved site GO:0005622|GO:0019843 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6790901|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS30215 4a7104b394f77f87ca30037c860d9b49 204 Hamap MF_01306_B 30S ribosomal protein S4 [rpsD]. 1 204 29.144 T 09-03-2017 IPR005709 Ribosomal protein S4, bacterial-type GO:0003735|GO:0006412|GO:0015935 TK78_RS30215 4a7104b394f77f87ca30037c860d9b49 204 Gene3D G3DSA:3.10.290.10 98 188 9.4E-24 T 09-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 TK78_RS30215 4a7104b394f77f87ca30037c860d9b49 204 TIGRFAM TIGR01017 rpsD_bact: ribosomal protein uS4 6 204 1.4E-60 T 09-03-2017 IPR005709 Ribosomal protein S4, bacterial-type GO:0003735|GO:0006412|GO:0015935 TK78_RS30215 4a7104b394f77f87ca30037c860d9b49 204 Pfam PF01479 S4 domain 92 139 9.2E-17 T 09-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 TK78_RS30215 4a7104b394f77f87ca30037c860d9b49 204 Pfam PF00163 Ribosomal protein S4/S9 N-terminal domain 6 91 1.2E-17 T 09-03-2017 IPR001912 Ribosomal protein S4/S9, N-terminal GO:0005622|GO:0019843 Reactome: R-HSA-6790901|Reactome: R-HSA-6791226 TK78_RS30215 4a7104b394f77f87ca30037c860d9b49 204 SUPERFAMILY SSF55174 6 204 1.96E-54 T 09-03-2017 TK78_RS30215 4a7104b394f77f87ca30037c860d9b49 204 SMART SM00363 92 150 1.4E-15 T 09-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 TK78_RS30215 4a7104b394f77f87ca30037c860d9b49 204 SMART SM01390 3 91 1.2E-31 T 09-03-2017 IPR001912 Ribosomal protein S4/S9, N-terminal GO:0005622|GO:0019843 Reactome: R-HSA-6790901|Reactome: R-HSA-6791226 TK78_RS30215 4a7104b394f77f87ca30037c860d9b49 204 Gene3D G3DSA:1.10.1050.10 5 97 4.2E-27 T 09-03-2017 IPR001912 Ribosomal protein S4/S9, N-terminal GO:0005622|GO:0019843 Reactome: R-HSA-6790901|Reactome: R-HSA-6791226 TK78_RS33600 1708c76639ad946655b0ba6f2378058d 309 SUPERFAMILY SSF52540 4 218 1.81E-54 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33600 1708c76639ad946655b0ba6f2378058d 309 ProSitePatterns PS00211 ABC transporters family signature. 131 145 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS33600 1708c76639ad946655b0ba6f2378058d 309 SMART SM00382 29 206 1.2E-9 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS33600 1708c76639ad946655b0ba6f2378058d 309 Gene3D G3DSA:3.40.50.300 2 219 1.6E-59 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33600 1708c76639ad946655b0ba6f2378058d 309 Pfam PF00005 ABC transporter 21 159 3.1E-26 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS15670 015aa6fd198f2517104e79e93a0cc8ba 191 SUPERFAMILY SSF88946 33 104 1.06E-14 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS15670 015aa6fd198f2517104e79e93a0cc8ba 191 TIGRFAM TIGR02983 SigE-fam_strep: RNA polymerase sigma-70 factor, sigma-E family 30 189 8.2E-56 T 09-03-2017 IPR014325 RNA polymerase sigma-E factor, actinobacteria GO:0016987 TK78_RS15670 015aa6fd198f2517104e79e93a0cc8ba 191 Gene3D G3DSA:1.10.1740.10 33 103 4.7E-15 T 09-03-2017 TK78_RS15670 015aa6fd198f2517104e79e93a0cc8ba 191 SUPERFAMILY SSF88659 114 189 3.36E-15 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS15670 015aa6fd198f2517104e79e93a0cc8ba 191 Pfam PF04542 Sigma-70 region 2 39 103 3.3E-11 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS15670 015aa6fd198f2517104e79e93a0cc8ba 191 Gene3D G3DSA:1.10.10.10 126 188 1.2E-15 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS15670 015aa6fd198f2517104e79e93a0cc8ba 191 Pfam PF08281 Sigma-70, region 4 130 183 2.6E-12 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS15670 015aa6fd198f2517104e79e93a0cc8ba 191 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 35 185 6.3E-22 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS33630 7ee8876dc76143180e0e3af1cce432d9 220 Gene3D G3DSA:3.90.550.10 15 165 4.8E-23 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS33630 7ee8876dc76143180e0e3af1cce432d9 220 Pfam PF09837 Uncharacterized protein conserved in bacteria (DUF2064) 54 161 4.2E-21 T 09-03-2017 IPR018641 Transferase 1, rSAM/selenodomain-associated TK78_RS33630 7ee8876dc76143180e0e3af1cce432d9 220 SUPERFAMILY SSF53448 16 198 2.81E-28 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS11460 ba96c47d95acd8e8a47650b676566660 742 SUPERFAMILY SSF56601 286 646 5.63E-75 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS11460 ba96c47d95acd8e8a47650b676566660 742 SUPERFAMILY SSF56601 239 257 5.63E-75 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS11460 ba96c47d95acd8e8a47650b676566660 742 Gene3D G3DSA:3.40.710.10 255 683 8.3E-92 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS11460 ba96c47d95acd8e8a47650b676566660 742 SUPERFAMILY SSF53955 66 268 1.57E-60 T 09-03-2017 IPR023346 Lysozyme-like domain TK78_RS11460 ba96c47d95acd8e8a47650b676566660 742 Gene3D G3DSA:1.10.3810.10 82 254 5.8E-61 T 09-03-2017 TK78_RS11460 ba96c47d95acd8e8a47650b676566660 742 Pfam PF00905 Penicillin binding protein transpeptidase domain 352 600 4.0E-32 T 09-03-2017 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 TK78_RS11460 ba96c47d95acd8e8a47650b676566660 742 Pfam PF00912 Transglycosylase 75 253 6.5E-58 T 09-03-2017 IPR001264 Glycosyl transferase, family 51 TK78_RS01275 f1f79c5163f1eeb8268b375dc9dde170 675 SUPERFAMILY SSF49503 117 170 2.55E-16 T 09-03-2017 IPR008972 Cupredoxin TK78_RS01275 f1f79c5163f1eeb8268b375dc9dde170 675 SUPERFAMILY SSF49503 209 279 2.55E-16 T 09-03-2017 IPR008972 Cupredoxin TK78_RS01275 f1f79c5163f1eeb8268b375dc9dde170 675 Pfam PF07731 Multicopper oxidase 528 660 6.4E-17 T 09-03-2017 IPR011706 Multicopper oxidase, type 2 GO:0005507|GO:0016491|GO:0055114 TK78_RS01275 f1f79c5163f1eeb8268b375dc9dde170 675 Gene3D G3DSA:2.60.40.420 282 418 5.5E-24 T 09-03-2017 IPR008972 Cupredoxin TK78_RS01275 f1f79c5163f1eeb8268b375dc9dde170 675 Gene3D G3DSA:2.60.40.420 527 660 2.5E-21 T 09-03-2017 IPR008972 Cupredoxin TK78_RS01275 f1f79c5163f1eeb8268b375dc9dde170 675 SUPERFAMILY SSF49503 283 417 7.58E-14 T 09-03-2017 IPR008972 Cupredoxin TK78_RS01275 f1f79c5163f1eeb8268b375dc9dde170 675 SUPERFAMILY SSF49503 556 572 2.28E-20 T 09-03-2017 IPR008972 Cupredoxin TK78_RS01275 f1f79c5163f1eeb8268b375dc9dde170 675 SUPERFAMILY SSF49503 611 658 2.28E-20 T 09-03-2017 IPR008972 Cupredoxin TK78_RS01275 f1f79c5163f1eeb8268b375dc9dde170 675 SUPERFAMILY SSF49503 329 363 2.28E-20 T 09-03-2017 IPR008972 Cupredoxin TK78_RS01275 f1f79c5163f1eeb8268b375dc9dde170 675 Gene3D G3DSA:2.60.40.420 112 171 1.1E-17 T 09-03-2017 IPR008972 Cupredoxin TK78_RS01275 f1f79c5163f1eeb8268b375dc9dde170 675 Gene3D G3DSA:2.60.40.420 212 281 1.1E-17 T 09-03-2017 IPR008972 Cupredoxin TK78_RS01275 f1f79c5163f1eeb8268b375dc9dde170 675 Pfam PF07732 Multicopper oxidase 211 278 1.1E-4 T 09-03-2017 IPR011707 Multicopper oxidase, type 3 GO:0005507 TK78_RS18095 21b0e92652927b5a0089a643d6c0af0c 194 SUPERFAMILY SSF48498 83 168 9.89E-9 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS18095 21b0e92652927b5a0089a643d6c0af0c 194 Gene3D G3DSA:1.10.357.10 11 190 4.9E-33 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS18095 21b0e92652927b5a0089a643d6c0af0c 194 SUPERFAMILY SSF46689 12 78 9.75E-16 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS18095 21b0e92652927b5a0089a643d6c0af0c 194 Pfam PF00440 Bacterial regulatory proteins, tetR family 17 62 1.3E-15 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS18095 21b0e92652927b5a0089a643d6c0af0c 194 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 17 30 2.2E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS18095 21b0e92652927b5a0089a643d6c0af0c 194 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 38 61 2.2E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS29715 f3319f5ad0b4487a8a7d68a835b91909 191 SMART SM00855 4 150 0.0031 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS29715 f3319f5ad0b4487a8a7d68a835b91909 191 Gene3D G3DSA:3.40.50.1240 10 184 6.4E-21 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS29715 f3319f5ad0b4487a8a7d68a835b91909 191 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 23 185 2.8E-22 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS29715 f3319f5ad0b4487a8a7d68a835b91909 191 SUPERFAMILY SSF53254 6 184 4.28E-30 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS30565 bcbaa62aa16dacb6da0df0da1d96cb63 255 Gene3D G3DSA:3.90.550.10 14 227 1.4E-23 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS30565 bcbaa62aa16dacb6da0df0da1d96cb63 255 SUPERFAMILY SSF53448 14 227 4.88E-41 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS30565 bcbaa62aa16dacb6da0df0da1d96cb63 255 Pfam PF00535 Glycosyl transferase family 2 17 178 3.0E-26 T 09-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 TK78_RS27165 14277e219da4c66e54a29cd4185c8f67 162 SUPERFAMILY SSF55729 7 160 4.63E-39 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS27165 14277e219da4c66e54a29cd4185c8f67 162 Pfam PF13673 Acetyltransferase (GNAT) domain 29 158 4.9E-18 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS27165 14277e219da4c66e54a29cd4185c8f67 162 Gene3D G3DSA:3.40.630.30 13 157 3.1E-37 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS07050 461a9baa3fdbe20c425a1e7ade6b18c4 414 Pfam PF00155 Aminotransferase class I and II 41 370 5.6E-39 T 09-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TK78_RS07050 461a9baa3fdbe20c425a1e7ade6b18c4 414 SUPERFAMILY SSF53383 3 370 2.61E-61 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS07050 461a9baa3fdbe20c425a1e7ade6b18c4 414 Gene3D G3DSA:3.90.1150.10 226 372 5.1E-18 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS07050 461a9baa3fdbe20c425a1e7ade6b18c4 414 ProSitePatterns PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 221 234 - T 09-03-2017 IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding site GO:0003824|GO:0009058|GO:0030170 TK78_RS07050 461a9baa3fdbe20c425a1e7ade6b18c4 414 Gene3D G3DSA:3.40.640.10 41 225 7.9E-41 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS23660 91b5feaa367786cfa1189960f05db5ba 498 Pfam PF00474 Sodium:solute symporter family 32 423 3.4E-36 T 09-03-2017 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 TK78_RS28935 caca4b6bc72e5f5cbc1fe29909df958a 305 Gene3D G3DSA:3.40.630.30 1 133 2.0E-17 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS28935 caca4b6bc72e5f5cbc1fe29909df958a 305 SUPERFAMILY SSF55729 1 137 4.12E-19 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS28935 caca4b6bc72e5f5cbc1fe29909df958a 305 Pfam PF13480 Acetyltransferase (GNAT) domain 157 270 1.1E-4 T 09-03-2017 TK78_RS28935 caca4b6bc72e5f5cbc1fe29909df958a 305 Pfam PF00583 Acetyltransferase (GNAT) family 52 131 2.7E-5 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS28935 caca4b6bc72e5f5cbc1fe29909df958a 305 SUPERFAMILY SSF55729 156 298 1.58E-13 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS28935 caca4b6bc72e5f5cbc1fe29909df958a 305 Gene3D G3DSA:3.40.630.30 168 298 4.3E-11 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS13265 caea57a192f8d14552371e410ddfa202 95 Gene3D G3DSA:1.20.5.1030 37 94 1.1E-21 T 09-03-2017 TK78_RS13265 caea57a192f8d14552371e410ddfa202 95 ProSitePatterns PS01067 Protein secE/sec61-gamma signature. 42 70 - T 09-03-2017 IPR001901 Protein translocase complex, SecE/Sec61-gamma subunit GO:0006605|GO:0006886|GO:0016020 Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 TK78_RS13265 caea57a192f8d14552371e410ddfa202 95 TIGRFAM TIGR00964 secE_bact: preprotein translocase, SecE subunit 41 95 1.3E-19 T 09-03-2017 IPR005807 SecE subunit of protein translocation complex GO:0009306|GO:0015450|GO:0016021 TK78_RS13265 caea57a192f8d14552371e410ddfa202 95 Pfam PF00584 SecE/Sec61-gamma subunits of protein translocation complex 42 92 6.6E-18 T 09-03-2017 IPR001901 Protein translocase complex, SecE/Sec61-gamma subunit GO:0006605|GO:0006886|GO:0016020 Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 TK78_RS13265 caea57a192f8d14552371e410ddfa202 95 Hamap MF_00422 Protein translocase subunit SecE [secE]. 37 92 12.794 T 09-03-2017 IPR022943 Preprotein translocase subunit SecE Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 TK78_RS07330 e43619c38b7e2a10c6f64f514744ed14 318 Pfam PF06626 Protein of unknown function (DUF1152) 108 300 1.3E-16 T 09-03-2017 IPR010581 Protein of unknown function DUF1152 TK78_RS23375 43ce14e068859b726ea2b6f76e6d3d61 609 TIGRFAM TIGR01135 glmS: glutamine-fructose-6-phosphate transaminase (isomerizing) 2 609 1.6E-222 T 09-03-2017 IPR005855 Glucosamine-fructose-6-phosphate aminotransferase, isomerising GO:0004360|GO:1901137 KEGG: 00250+2.6.1.16|KEGG: 00520+2.6.1.16|MetaCyc: PWY-6749|Reactome: R-HSA-446210 TK78_RS23375 43ce14e068859b726ea2b6f76e6d3d61 609 Hamap MF_00164 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] [glmS]. 1 609 37.5 T 09-03-2017 IPR005855 Glucosamine-fructose-6-phosphate aminotransferase, isomerising GO:0004360|GO:1901137 KEGG: 00250+2.6.1.16|KEGG: 00520+2.6.1.16|MetaCyc: PWY-6749|Reactome: R-HSA-446210 TK78_RS23375 43ce14e068859b726ea2b6f76e6d3d61 609 SUPERFAMILY SSF53697 249 609 3.9E-99 T 09-03-2017 TK78_RS23375 43ce14e068859b726ea2b6f76e6d3d61 609 Pfam PF13522 Glutamine amidotransferase domain 68 197 6.6E-20 T 09-03-2017 TK78_RS23375 43ce14e068859b726ea2b6f76e6d3d61 609 Pfam PF01380 SIS domain 299 421 1.4E-28 T 09-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 TK78_RS23375 43ce14e068859b726ea2b6f76e6d3d61 609 Pfam PF01380 SIS domain 466 591 5.0E-22 T 09-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 TK78_RS23375 43ce14e068859b726ea2b6f76e6d3d61 609 SUPERFAMILY SSF56235 2 239 6.69E-66 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS23375 43ce14e068859b726ea2b6f76e6d3d61 609 Gene3D G3DSA:3.40.50.10490 447 609 4.1E-57 T 09-03-2017 TK78_RS23375 43ce14e068859b726ea2b6f76e6d3d61 609 Gene3D G3DSA:3.60.20.10 2 244 4.8E-74 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS23375 43ce14e068859b726ea2b6f76e6d3d61 609 Gene3D G3DSA:3.40.50.10490 249 446 1.7E-68 T 09-03-2017 TK78_RS23280 6d2ddd677aaf4ee30c4d488426c01d06 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 131 147 1.2E-36 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS23280 6d2ddd677aaf4ee30c4d488426c01d06 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 78 89 1.2E-36 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS23280 6d2ddd677aaf4ee30c4d488426c01d06 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 178 195 1.2E-36 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS23280 6d2ddd677aaf4ee30c4d488426c01d06 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 157 176 1.2E-36 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS23280 6d2ddd677aaf4ee30c4d488426c01d06 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 228 248 1.2E-36 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS23280 6d2ddd677aaf4ee30c4d488426c01d06 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 9 26 1.2E-36 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS23280 6d2ddd677aaf4ee30c4d488426c01d06 268 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 14 264 1.3E-50 T 09-03-2017 TK78_RS23280 6d2ddd677aaf4ee30c4d488426c01d06 268 SUPERFAMILY SSF51735 7 264 3.25E-70 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS23280 6d2ddd677aaf4ee30c4d488426c01d06 268 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 137 145 8.2E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS23280 6d2ddd677aaf4ee30c4d488426c01d06 268 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 78 89 8.2E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS23280 6d2ddd677aaf4ee30c4d488426c01d06 268 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 157 176 8.2E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS23280 6d2ddd677aaf4ee30c4d488426c01d06 268 Gene3D G3DSA:3.40.50.720 2 264 2.1E-73 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS23435 bfdcd7f717b67c1612c53eca0e22d1dc 1448 Gene3D G3DSA:2.70.98.10 57 381 3.4E-87 T 09-03-2017 IPR014718 Glycoside hydrolase-type carbohydrate-binding GO:0003824|GO:0005975|GO:0030246 TK78_RS23435 bfdcd7f717b67c1612c53eca0e22d1dc 1448 Pfam PF16656 Purple acid Phosphatase, N-terminal domain 998 1090 5.9E-15 T 09-03-2017 IPR015914 Purple acid phosphatase, N-terminal GO:0003993|GO:0046872 TK78_RS23435 bfdcd7f717b67c1612c53eca0e22d1dc 1448 TIGRFAM TIGR01180 aman2_put: putative alpha-1,2-mannosidase 51 779 3.0E-135 T 09-03-2017 IPR005887 Alpha-1,2-mannosidase, putative TK78_RS23435 bfdcd7f717b67c1612c53eca0e22d1dc 1448 SUPERFAMILY SSF49363 984 1092 1.31E-14 T 09-03-2017 IPR008963 Purple acid phosphatase-like, N-terminal GO:0003993|GO:0046872 TK78_RS23435 bfdcd7f717b67c1612c53eca0e22d1dc 1448 Pfam PF00149 Calcineurin-like phosphoesterase 1119 1330 7.5E-12 T 09-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 TK78_RS23435 bfdcd7f717b67c1612c53eca0e22d1dc 1448 SUPERFAMILY SSF56300 1098 1403 5.35E-36 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS23435 bfdcd7f717b67c1612c53eca0e22d1dc 1448 Gene3D G3DSA:1.20.1610.10 501 642 8.5E-36 T 09-03-2017 TK78_RS23435 bfdcd7f717b67c1612c53eca0e22d1dc 1448 Gene3D G3DSA:2.60.40.380 997 1092 2.1E-12 T 09-03-2017 IPR015914 Purple acid phosphatase, N-terminal GO:0003993|GO:0046872 TK78_RS23435 bfdcd7f717b67c1612c53eca0e22d1dc 1448 Gene3D G3DSA:3.30.2080.10 643 788 6.5E-48 T 09-03-2017 TK78_RS23435 bfdcd7f717b67c1612c53eca0e22d1dc 1448 Gene3D G3DSA:1.20.1050.60 406 492 1.3E-15 T 09-03-2017 TK78_RS23435 bfdcd7f717b67c1612c53eca0e22d1dc 1448 SUPERFAMILY SSF48208 321 755 8.67E-16 T 09-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 TK78_RS23435 bfdcd7f717b67c1612c53eca0e22d1dc 1448 Pfam PF07971 Glycosyl hydrolase family 92 302 777 4.6E-132 T 09-03-2017 IPR012939 Glycosyl hydrolase family 92 TK78_RS23435 bfdcd7f717b67c1612c53eca0e22d1dc 1448 Gene3D G3DSA:3.60.21.10 1095 1434 1.4E-52 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS26910 0590d509663b78525b4b35bb3a9197b7 233 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 185 201 1.2E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS26910 0590d509663b78525b4b35bb3a9197b7 233 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 201 213 1.2E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS26910 0590d509663b78525b4b35bb3a9197b7 233 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 171 185 1.2E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS26910 0590d509663b78525b4b35bb3a9197b7 233 SMART SM00448 17 129 1.3E-34 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS26910 0590d509663b78525b4b35bb3a9197b7 233 SUPERFAMILY SSF52172 16 134 1.85E-32 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS26910 0590d509663b78525b4b35bb3a9197b7 233 SMART SM00421 168 225 8.6E-27 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS26910 0590d509663b78525b4b35bb3a9197b7 233 Pfam PF00196 Bacterial regulatory proteins, luxR family 170 225 1.9E-20 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS26910 0590d509663b78525b4b35bb3a9197b7 233 Gene3D G3DSA:3.40.50.2300 15 170 1.2E-36 T 09-03-2017 TK78_RS26910 0590d509663b78525b4b35bb3a9197b7 233 Gene3D G3DSA:1.10.10.10 171 230 4.3E-29 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS26910 0590d509663b78525b4b35bb3a9197b7 233 Pfam PF00072 Response regulator receiver domain 19 130 1.4E-26 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS26910 0590d509663b78525b4b35bb3a9197b7 233 ProSitePatterns PS00622 LuxR-type HTH domain signature. 185 212 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS26910 0590d509663b78525b4b35bb3a9197b7 233 SUPERFAMILY SSF46894 160 230 1.36E-23 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS01620 edc877a281b20c2f1ce0f5c3be274a3b 452 Pfam PF04932 O-Antigen ligase 219 375 2.7E-12 T 09-03-2017 IPR007016 O-antigen ligase-related TK78_RS33415 f1d3eb92ec3f771472586f24620ddaf0 346 Gene3D G3DSA:3.90.180.10 1 177 5.2E-50 T 09-03-2017 IPR011032 GroES-like TK78_RS33415 f1d3eb92ec3f771472586f24620ddaf0 346 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 61 75 - T 09-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 TK78_RS33415 f1d3eb92ec3f771472586f24620ddaf0 346 SMART SM00829 10 342 2.7E-5 T 09-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 TK78_RS33415 f1d3eb92ec3f771472586f24620ddaf0 346 Pfam PF00107 Zinc-binding dehydrogenase 182 306 1.8E-24 T 09-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 TK78_RS33415 f1d3eb92ec3f771472586f24620ddaf0 346 SUPERFAMILY SSF50129 314 342 1.03E-44 T 09-03-2017 IPR011032 GroES-like TK78_RS33415 f1d3eb92ec3f771472586f24620ddaf0 346 SUPERFAMILY SSF50129 1 147 1.03E-44 T 09-03-2017 IPR011032 GroES-like TK78_RS33415 f1d3eb92ec3f771472586f24620ddaf0 346 Gene3D G3DSA:3.40.50.720 178 279 3.8E-28 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS33415 f1d3eb92ec3f771472586f24620ddaf0 346 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 25 139 1.3E-30 T 09-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 TK78_RS33415 f1d3eb92ec3f771472586f24620ddaf0 346 SUPERFAMILY SSF51735 142 312 8.73E-35 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS10620 9da19f8e0e560f8ccc737e89f66af37b 949 Pfam PF03706 Lysylphosphatidylglycerol synthase TM region 647 936 1.5E-33 T 09-03-2017 IPR022791 Lysylphosphatidylglycerol synthetase/glycosyltransferase AglD TK78_RS10620 9da19f8e0e560f8ccc737e89f66af37b 949 Gene3D G3DSA:1.10.510.10 393 459 1.6E-4 T 09-03-2017 TK78_RS10620 9da19f8e0e560f8ccc737e89f66af37b 949 SUPERFAMILY SSF56112 309 459 6.49E-8 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS17210 e099f0879116bcdd9fd7c749158b4aa7 445 Pfam PF01554 MatE 243 399 2.3E-24 T 09-03-2017 IPR002528 Multi antimicrobial extrusion protein GO:0006855|GO:0015238|GO:0015297|GO:0016020|GO:0055085 Reactome: R-HSA-425366 TK78_RS17210 e099f0879116bcdd9fd7c749158b4aa7 445 Pfam PF01554 MatE 25 184 1.0E-28 T 09-03-2017 IPR002528 Multi antimicrobial extrusion protein GO:0006855|GO:0015238|GO:0015297|GO:0016020|GO:0055085 Reactome: R-HSA-425366 TK78_RS17210 e099f0879116bcdd9fd7c749158b4aa7 445 TIGRFAM TIGR00797 matE: MATE efflux family protein 25 415 1.7E-106 T 09-03-2017 IPR002528 Multi antimicrobial extrusion protein GO:0006855|GO:0015238|GO:0015297|GO:0016020|GO:0055085 Reactome: R-HSA-425366 TK78_RS17210 e099f0879116bcdd9fd7c749158b4aa7 445 PIRSF PIRSF006603 11 445 2.0E-67 T 09-03-2017 IPR002528 Multi antimicrobial extrusion protein GO:0006855|GO:0015238|GO:0015297|GO:0016020|GO:0055085 Reactome: R-HSA-425366 TK78_RS19885 c61ef5a91da50c0d21ecc89bdf8d78c1 206 Pfam PF00440 Bacterial regulatory proteins, tetR family 30 76 7.0E-17 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS19885 c61ef5a91da50c0d21ecc89bdf8d78c1 206 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 51 74 9.6E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS19885 c61ef5a91da50c0d21ecc89bdf8d78c1 206 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 30 43 9.6E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS19885 c61ef5a91da50c0d21ecc89bdf8d78c1 206 SUPERFAMILY SSF46689 20 84 1.49E-18 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS19885 c61ef5a91da50c0d21ecc89bdf8d78c1 206 Gene3D G3DSA:1.10.10.60 17 75 1.6E-21 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS19885 c61ef5a91da50c0d21ecc89bdf8d78c1 206 Gene3D G3DSA:1.10.357.10 79 203 4.4E-51 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS19885 c61ef5a91da50c0d21ecc89bdf8d78c1 206 SUPERFAMILY SSF48498 95 204 8.4E-37 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS21635 4bc61dfc7302e2fda643023db1625b38 406 Gene3D G3DSA:3.40.47.10 289 404 1.1E-57 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS21635 4bc61dfc7302e2fda643023db1625b38 406 Gene3D G3DSA:3.40.47.10 170 209 1.1E-57 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS21635 4bc61dfc7302e2fda643023db1625b38 406 Pfam PF02803 Thiolase, C-terminal domain 282 404 5.0E-48 T 09-03-2017 IPR020617 Thiolase, C-terminal GO:0008152|GO:0016747 TK78_RS21635 4bc61dfc7302e2fda643023db1625b38 406 SUPERFAMILY SSF53901 3 282 1.25E-66 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS21635 4bc61dfc7302e2fda643023db1625b38 406 PIRSF PIRSF000429 1 406 2.8E-129 T 09-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 TK78_RS21635 4bc61dfc7302e2fda643023db1625b38 406 Pfam PF00108 Thiolase, N-terminal domain 5 274 5.0E-61 T 09-03-2017 IPR020616 Thiolase, N-terminal GO:0008152|GO:0016747 TK78_RS21635 4bc61dfc7302e2fda643023db1625b38 406 Gene3D G3DSA:3.40.47.10 4 125 2.9E-61 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS21635 4bc61dfc7302e2fda643023db1625b38 406 Gene3D G3DSA:3.40.47.10 210 288 2.9E-61 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS21635 4bc61dfc7302e2fda643023db1625b38 406 TIGRFAM TIGR01930 AcCoA-C-Actrans: acetyl-CoA C-acyltransferase 6 403 2.9E-140 T 09-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 TK78_RS21635 4bc61dfc7302e2fda643023db1625b38 406 SUPERFAMILY SSF53901 283 404 9.05E-44 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS21635 4bc61dfc7302e2fda643023db1625b38 406 ProSitePatterns PS00737 Thiolases signature 2. 351 367 - T 09-03-2017 IPR020613 Thiolase, conserved site GO:0008152|GO:0016747 TK78_RS07905 3ce5f36476cf4c22b982b9a3ae923967 837 Gene3D G3DSA:3.40.50.300 424 510 5.7E-6 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07905 3ce5f36476cf4c22b982b9a3ae923967 837 Gene3D G3DSA:3.40.50.300 628 764 5.7E-6 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07905 3ce5f36476cf4c22b982b9a3ae923967 837 SUPERFAMILY SSF52540 418 749 4.13E-10 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13240 9b71494b69e8ec1b82921def1db3f2cd 185 Hamap MF_00362 50S ribosomal protein L10 [rplJ]. 1 158 25.602 T 09-03-2017 IPR022973 Ribosomal protein L10 TK78_RS13240 9b71494b69e8ec1b82921def1db3f2cd 185 SUPERFAMILY SSF160369 1 169 3.66E-52 T 09-03-2017 TK78_RS13240 9b71494b69e8ec1b82921def1db3f2cd 185 ProSitePatterns PS01109 Ribosomal protein L10 signature. 6 40 - T 09-03-2017 IPR002363 Ribosomal protein L10, eubacterial, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13240 9b71494b69e8ec1b82921def1db3f2cd 185 Pfam PF00466 Ribosomal protein L10 2 98 3.9E-27 T 09-03-2017 IPR001790 Ribosomal protein L10P GO:0005622|GO:0042254 TK78_RS13240 9b71494b69e8ec1b82921def1db3f2cd 185 ProDom PD968187 BETA-DEFENSIN ANTIBIOTIC PRECURSOR ANTIMICROBIAL DEFENSIN BETA SIGNAL DEFENSIN BD-32 DEFB-32 60 138 0.009 T 09-03-2017 TK78_RS27485 f2b09f910b95376b9d03cd31907fee55 296 SMART SM00882 11 229 6.1E-30 T 09-03-2017 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 TK78_RS27485 f2b09f910b95376b9d03cd31907fee55 296 Pfam PF01144 Coenzyme A transferase 12 225 3.6E-34 T 09-03-2017 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 TK78_RS27485 f2b09f910b95376b9d03cd31907fee55 296 SUPERFAMILY SSF100950 9 277 2.15E-66 T 09-03-2017 TK78_RS27485 f2b09f910b95376b9d03cd31907fee55 296 Gene3D G3DSA:3.40.1080.10 162 290 2.5E-69 T 09-03-2017 TK78_RS27485 f2b09f910b95376b9d03cd31907fee55 296 Gene3D G3DSA:3.40.1080.10 9 123 2.5E-69 T 09-03-2017 TK78_RS20895 64973f4de62c4e0012c9765beffc870a 300 SUPERFAMILY SSF53448 10 290 1.08E-64 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS20895 64973f4de62c4e0012c9765beffc870a 300 Gene3D G3DSA:3.90.550.10 10 282 1.4E-74 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS20895 64973f4de62c4e0012c9765beffc870a 300 Pfam PF00483 Nucleotidyl transferase 10 275 1.8E-27 T 09-03-2017 IPR005835 Nucleotidyl transferase domain GO:0009058|GO:0016779 TK78_RS20895 64973f4de62c4e0012c9765beffc870a 300 TIGRFAM TIGR01099 galU: UTP--glucose-1-phosphate uridylyltransferase 8 273 4.5E-104 T 09-03-2017 IPR005771 UTP--glucose-1-phosphate uridylyltransferase, bacterial/archaeal-type GO:0003983|GO:0006011 KEGG: 00040+2.7.7.9|KEGG: 00052+2.7.7.9|KEGG: 00500+2.7.7.9|KEGG: 00520+2.7.7.9|MetaCyc: PWY-3801|MetaCyc: PWY-6527|MetaCyc: PWY-7238|MetaCyc: PWY-7343 TK78_RS20875 cb899d4ee98c0e1ef20b3b8a8867a0c7 426 Pfam PF07690 Major Facilitator Superfamily 34 308 2.1E-14 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS20875 cb899d4ee98c0e1ef20b3b8a8867a0c7 426 SUPERFAMILY SSF103473 16 407 3.4E-30 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS20875 cb899d4ee98c0e1ef20b3b8a8867a0c7 426 Gene3D G3DSA:1.20.1250.20 16 218 5.2E-9 T 09-03-2017 TK78_RS20875 cb899d4ee98c0e1ef20b3b8a8867a0c7 426 Gene3D G3DSA:1.20.1250.20 219 401 2.6E-13 T 09-03-2017 TK78_RS33885 b2d1b0322960c1d63ed12a00050918cb 263 Pfam PF00005 ABC transporter 19 167 2.5E-30 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS33885 b2d1b0322960c1d63ed12a00050918cb 263 Gene3D G3DSA:3.40.50.300 2 233 1.1E-67 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33885 b2d1b0322960c1d63ed12a00050918cb 263 SUPERFAMILY SSF52540 3 228 1.36E-63 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33885 b2d1b0322960c1d63ed12a00050918cb 263 SMART SM00382 27 215 1.1E-20 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS06980 66ee3ea9ddc10f79fc25ab177ed8815f 445 Pfam PF02687 FtsX-like permease family 65 176 3.6E-14 T 09-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 TK78_RS06980 66ee3ea9ddc10f79fc25ab177ed8815f 445 Pfam PF02687 FtsX-like permease family 323 435 8.7E-12 T 09-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 TK78_RS11420 d7c795b92a59f1dfb420c27f0af323c9 433 SUPERFAMILY SSF101821 90 212 3.2E-32 T 09-03-2017 TK78_RS11420 d7c795b92a59f1dfb420c27f0af323c9 433 Hamap MF_00467 Probable M18 family aminopeptidase 2 [apeB]. 1 432 53.026 T 09-03-2017 IPR022984 M18 family aminopeptidase 2, putative GO:0004177 TK78_RS11420 d7c795b92a59f1dfb420c27f0af323c9 433 Gene3D G3DSA:3.40.630.10 8 88 6.7E-102 T 09-03-2017 TK78_RS11420 d7c795b92a59f1dfb420c27f0af323c9 433 Gene3D G3DSA:3.40.630.10 221 429 6.7E-102 T 09-03-2017 TK78_RS11420 d7c795b92a59f1dfb420c27f0af323c9 433 Pfam PF02127 Aminopeptidase I zinc metalloprotease (M18) 16 420 6.8E-132 T 09-03-2017 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 TK78_RS11420 d7c795b92a59f1dfb420c27f0af323c9 433 PRINTS PR00932 Aminopeptidase I zinc metalloprotease (M18) signature 397 412 8.3E-48 T 09-03-2017 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 TK78_RS11420 d7c795b92a59f1dfb420c27f0af323c9 433 PRINTS PR00932 Aminopeptidase I zinc metalloprotease (M18) signature 111 131 8.3E-48 T 09-03-2017 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 TK78_RS11420 d7c795b92a59f1dfb420c27f0af323c9 433 PRINTS PR00932 Aminopeptidase I zinc metalloprotease (M18) signature 308 324 8.3E-48 T 09-03-2017 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 TK78_RS11420 d7c795b92a59f1dfb420c27f0af323c9 433 PRINTS PR00932 Aminopeptidase I zinc metalloprotease (M18) signature 147 164 8.3E-48 T 09-03-2017 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 TK78_RS11420 d7c795b92a59f1dfb420c27f0af323c9 433 PRINTS PR00932 Aminopeptidase I zinc metalloprotease (M18) signature 78 94 8.3E-48 T 09-03-2017 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 TK78_RS11420 d7c795b92a59f1dfb420c27f0af323c9 433 PRINTS PR00932 Aminopeptidase I zinc metalloprotease (M18) signature 265 283 8.3E-48 T 09-03-2017 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 TK78_RS11420 d7c795b92a59f1dfb420c27f0af323c9 433 Gene3D G3DSA:2.30.250.10 89 218 6.5E-40 T 09-03-2017 IPR023358 Peptidase M18, domain 2 GO:0004177 TK78_RS11420 d7c795b92a59f1dfb420c27f0af323c9 433 SUPERFAMILY SSF53187 212 428 8.53E-95 T 09-03-2017 TK78_RS11420 d7c795b92a59f1dfb420c27f0af323c9 433 SUPERFAMILY SSF53187 7 89 8.53E-95 T 09-03-2017 TK78_RS00735 6e59494b1b910dca422dbbf5ec1ba506 545 Gene3D G3DSA:3.20.20.80 396 527 5.6E-81 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS00735 6e59494b1b910dca422dbbf5ec1ba506 545 Gene3D G3DSA:3.20.20.80 135 356 5.6E-81 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS00735 6e59494b1b910dca422dbbf5ec1ba506 545 Pfam PF00728 Glycosyl hydrolase family 20, catalytic domain 147 501 1.9E-50 T 09-03-2017 IPR015883 Glycoside hydrolase family 20, catalytic domain GO:0004553|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 TK78_RS00735 6e59494b1b910dca422dbbf5ec1ba506 545 SUPERFAMILY SSF55545 3 145 6.45E-12 T 09-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS00735 6e59494b1b910dca422dbbf5ec1ba506 545 Pfam PF02838 Glycosyl hydrolase family 20, domain 2 3 144 8.6E-11 T 09-03-2017 IPR015882 Beta-hexosaminidase, bacteial type, N-terminal KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 TK78_RS00735 6e59494b1b910dca422dbbf5ec1ba506 545 SUPERFAMILY SSF51445 147 361 1.23E-70 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS00735 6e59494b1b910dca422dbbf5ec1ba506 545 SUPERFAMILY SSF51445 396 513 1.23E-70 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS00735 6e59494b1b910dca422dbbf5ec1ba506 545 Gene3D G3DSA:3.30.379.10 2 134 6.4E-14 T 09-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS00735 6e59494b1b910dca422dbbf5ec1ba506 545 PRINTS PR00738 Glycosyl hydrolase family 20 signature 141 158 8.8E-32 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS00735 6e59494b1b910dca422dbbf5ec1ba506 545 PRINTS PR00738 Glycosyl hydrolase family 20 signature 465 481 8.8E-32 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS00735 6e59494b1b910dca422dbbf5ec1ba506 545 PRINTS PR00738 Glycosyl hydrolase family 20 signature 170 191 8.8E-32 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS00735 6e59494b1b910dca422dbbf5ec1ba506 545 PRINTS PR00738 Glycosyl hydrolase family 20 signature 225 242 8.8E-32 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS00735 6e59494b1b910dca422dbbf5ec1ba506 545 PRINTS PR00738 Glycosyl hydrolase family 20 signature 483 500 8.8E-32 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS00735 6e59494b1b910dca422dbbf5ec1ba506 545 PRINTS PR00738 Glycosyl hydrolase family 20 signature 294 307 8.8E-32 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS00735 6e59494b1b910dca422dbbf5ec1ba506 545 PRINTS PR00738 Glycosyl hydrolase family 20 signature 108 128 8.8E-32 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS15375 13cfc7965e86d0ebd5e365944df7d87d 331 Gene3D G3DSA:3.40.50.300 108 249 1.3E-28 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15375 13cfc7965e86d0ebd5e365944df7d87d 331 Gene3D G3DSA:3.40.50.300 1 75 1.3E-28 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15375 13cfc7965e86d0ebd5e365944df7d87d 331 Pfam PF01656 CobQ/CobB/MinD/ParA nucleotide binding domain 6 221 1.2E-12 T 09-03-2017 IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain TK78_RS15375 13cfc7965e86d0ebd5e365944df7d87d 331 SUPERFAMILY SSF52540 99 242 3.98E-20 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15375 13cfc7965e86d0ebd5e365944df7d87d 331 SUPERFAMILY SSF52540 1 51 3.98E-20 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31520 c56fa7b821327a673911c8c518e7995f 445 Gene3D G3DSA:3.10.580.10 208 330 1.2E-15 T 09-03-2017 TK78_RS31520 c56fa7b821327a673911c8c518e7995f 445 Pfam PF01595 Domain of unknown function DUF21 9 201 6.3E-34 T 09-03-2017 IPR002550 Domain of unknown function DUF21 TK78_RS31520 c56fa7b821327a673911c8c518e7995f 445 SUPERFAMILY SSF54631 212 347 1.04E-24 T 09-03-2017 TK78_RS31520 c56fa7b821327a673911c8c518e7995f 445 Gene3D G3DSA:3.30.465.10 331 430 8.4E-20 T 09-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 TK78_RS31520 c56fa7b821327a673911c8c518e7995f 445 Pfam PF00571 CBS domain 284 335 3.1E-4 T 09-03-2017 IPR000644 CBS domain TK78_RS31520 c56fa7b821327a673911c8c518e7995f 445 SMART SM01091 357 434 3.1E-16 T 09-03-2017 IPR005170 Transporter-associated domain TK78_RS31520 c56fa7b821327a673911c8c518e7995f 445 SUPERFAMILY SSF56176 363 441 3.0E-15 T 09-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 TK78_RS31520 c56fa7b821327a673911c8c518e7995f 445 Pfam PF03471 Transporter associated domain 364 429 2.7E-14 T 09-03-2017 IPR005170 Transporter-associated domain TK78_RS13280 9d760acaef863d5a09b60d736d57d9f8 337 SUPERFAMILY SSF51556 6 334 1.95E-67 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS13280 9d760acaef863d5a09b60d736d57d9f8 337 Gene3D G3DSA:3.20.20.140 6 334 8.8E-82 T 09-03-2017 TK78_RS13280 9d760acaef863d5a09b60d736d57d9f8 337 Pfam PF00962 Adenosine/AMP deaminase 8 329 2.5E-96 T 09-03-2017 IPR001365 Adenosine/AMP deaminase domain GO:0019239 Reactome: R-HSA-74217 TK78_RS13280 9d760acaef863d5a09b60d736d57d9f8 337 ProSitePatterns PS00485 Adenosine and AMP deaminase signature. 275 281 - T 09-03-2017 IPR006650 Adenosine/AMP deaminase active site GO:0009168|GO:0019239 Reactome: R-HSA-74217 TK78_RS13280 9d760acaef863d5a09b60d736d57d9f8 337 TIGRFAM TIGR01430 aden_deam: adenosine deaminase 8 330 4.7E-116 T 09-03-2017 IPR006330 Adenosine/adenine deaminase GO:0019239 Reactome: R-HSA-74217 TK78_RS27400 23a1afdd570d8011b064d88a21ff96d5 362 Pfam PF03747 ADP-ribosylglycohydrolase 12 293 2.1E-55 T 09-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 TK78_RS27400 23a1afdd570d8011b064d88a21ff96d5 362 SUPERFAMILY SSF101478 7 299 4.18E-52 T 09-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 TK78_RS01860 c16981cf7dc46287331707c9c66346ec 537 Pfam PF12831 FAD dependent oxidoreductase 6 511 2.1E-111 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS01860 c16981cf7dc46287331707c9c66346ec 537 SUPERFAMILY SSF51905 463 510 6.71E-22 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS01860 c16981cf7dc46287331707c9c66346ec 537 SUPERFAMILY SSF51905 4 190 6.71E-22 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS01860 c16981cf7dc46287331707c9c66346ec 537 Gene3D G3DSA:3.50.50.60 5 240 2.2E-20 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS01860 c16981cf7dc46287331707c9c66346ec 537 Gene3D G3DSA:3.50.50.60 424 507 2.2E-20 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS24095 ca770c83a7e0a9af4b946ad90576ba57 332 Gene3D G3DSA:3.40.50.150 22 252 2.2E-65 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS24095 ca770c83a7e0a9af4b946ad90576ba57 332 SUPERFAMILY SSF53335 82 215 2.87E-30 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS24095 ca770c83a7e0a9af4b946ad90576ba57 332 SUPERFAMILY SSF53335 17 51 2.87E-30 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS24095 ca770c83a7e0a9af4b946ad90576ba57 332 Pfam PF01135 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) 98 216 4.7E-26 T 09-03-2017 TK78_RS00490 69ebaa9a30eef48723e495c0469656f5 644 SUPERFAMILY SSF51445 9 332 1.68E-44 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS00490 69ebaa9a30eef48723e495c0469656f5 644 Gene3D G3DSA:3.20.20.80 3 333 1.7E-39 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS00490 69ebaa9a30eef48723e495c0469656f5 644 Pfam PF00150 Cellulase (glycosyl hydrolase family 5) 29 294 4.2E-10 T 09-03-2017 IPR001547 Glycoside hydrolase, family 5 GO:0004553|GO:0005975 TK78_RS15775 cc511771fe908f3a62bd98635f1065e8 195 Gene3D G3DSA:1.10.1740.10 18 127 1.3E-35 T 09-03-2017 TK78_RS15775 cc511771fe908f3a62bd98635f1065e8 195 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 33 189 4.2E-31 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS15775 cc511771fe908f3a62bd98635f1065e8 195 SUPERFAMILY SSF88659 112 192 6.35E-13 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS15775 cc511771fe908f3a62bd98635f1065e8 195 SUPERFAMILY SSF88946 18 116 1.07E-31 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS15775 cc511771fe908f3a62bd98635f1065e8 195 Pfam PF04542 Sigma-70 region 2 38 104 4.3E-23 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS15775 cc511771fe908f3a62bd98635f1065e8 195 Pfam PF08281 Sigma-70, region 4 136 187 5.4E-13 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS15775 cc511771fe908f3a62bd98635f1065e8 195 Gene3D G3DSA:1.10.10.10 131 192 6.8E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS04270 1f3afdfa568ed7e22a26a6f3935c9201 405 Pfam PF02653 Branched-chain amino acid transport system / permease component 62 359 1.8E-36 T 09-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 TK78_RS19405 d898bacc41dcdb29219cf66c702c7888 198 Gene3D G3DSA:1.25.40.20 8 196 2.8E-37 T 09-03-2017 IPR020683 Ankyrin repeat-containing domain TK78_RS19405 d898bacc41dcdb29219cf66c702c7888 198 SUPERFAMILY SSF48403 8 195 4.5E-37 T 09-03-2017 IPR020683 Ankyrin repeat-containing domain TK78_RS19405 d898bacc41dcdb29219cf66c702c7888 198 SMART SM00248 36 65 0.0028 T 09-03-2017 IPR002110 Ankyrin repeat GO:0005515 TK78_RS19405 d898bacc41dcdb29219cf66c702c7888 198 SMART SM00248 136 170 8.0 T 09-03-2017 IPR002110 Ankyrin repeat GO:0005515 TK78_RS19405 d898bacc41dcdb29219cf66c702c7888 198 SMART SM00248 3 32 1500.0 T 09-03-2017 IPR002110 Ankyrin repeat GO:0005515 TK78_RS19405 d898bacc41dcdb29219cf66c702c7888 198 Pfam PF12796 Ankyrin repeats (3 copies) 8 67 2.8E-6 T 09-03-2017 IPR020683 Ankyrin repeat-containing domain TK78_RS16930 d8a1d48c8a9b822895b0ef3292a585fd 229 Gene3D G3DSA:3.30.565.10 52 168 3.0E-5 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS16930 d8a1d48c8a9b822895b0ef3292a585fd 229 Pfam PF13581 Histidine kinase-like ATPase domain 49 161 2.3E-12 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS16930 d8a1d48c8a9b822895b0ef3292a585fd 229 SUPERFAMILY SSF55874 71 170 1.64E-7 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS00895 d667499b70900bd6a89538131bc71745 125 Gene3D G3DSA:3.10.180.10 2 123 3.1E-14 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS00895 d667499b70900bd6a89538131bc71745 125 SUPERFAMILY SSF54593 1 123 3.76E-14 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS18945 abce6f9e83cf4c4ae2478b112de72977 167 Gene3D G3DSA:1.10.260.40 8 108 5.5E-22 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS18945 abce6f9e83cf4c4ae2478b112de72977 167 SUPERFAMILY SSF47413 8 69 9.12E-17 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS18945 abce6f9e83cf4c4ae2478b112de72977 167 Pfam PF01381 Helix-turn-helix 13 65 3.7E-15 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS18945 abce6f9e83cf4c4ae2478b112de72977 167 SMART SM00530 12 67 3.7E-16 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS27635 c8d4e7832f5a6cd3a824ddca2a856a3d 764 TIGRFAM TIGR01701 Fdhalpha-like: oxidoreductase alpha (molybdopterin) subunit 24 755 9.7E-285 T 09-03-2017 IPR010046 Oxidoreductase alpha (molybdopterin) subunit GO:0008863|GO:0030151|GO:0051539 TK78_RS27635 c8d4e7832f5a6cd3a824ddca2a856a3d 764 PIRSF PIRSF000144 5 761 0.0 T 09-03-2017 IPR010046 Oxidoreductase alpha (molybdopterin) subunit GO:0008863|GO:0030151|GO:0051539 TK78_RS27635 c8d4e7832f5a6cd3a824ddca2a856a3d 764 SUPERFAMILY SSF53706 58 632 1.57E-137 T 09-03-2017 TK78_RS27635 c8d4e7832f5a6cd3a824ddca2a856a3d 764 Gene3D G3DSA:3.40.228.10 194 394 6.3E-55 T 09-03-2017 TK78_RS27635 c8d4e7832f5a6cd3a824ddca2a856a3d 764 Gene3D G3DSA:2.40.40.20 632 755 1.5E-9 T 09-03-2017 TK78_RS27635 c8d4e7832f5a6cd3a824ddca2a856a3d 764 Gene3D G3DSA:3.40.50.740 120 193 2.1E-49 T 09-03-2017 TK78_RS27635 c8d4e7832f5a6cd3a824ddca2a856a3d 764 Gene3D G3DSA:3.40.50.740 395 629 2.1E-49 T 09-03-2017 TK78_RS27635 c8d4e7832f5a6cd3a824ddca2a856a3d 764 SUPERFAMILY SSF50692 633 756 3.84E-16 T 09-03-2017 IPR009010 Aspartate decarboxylase-like domain TK78_RS27635 c8d4e7832f5a6cd3a824ddca2a856a3d 764 Pfam PF01568 Molydopterin dinucleotide binding domain 643 750 2.2E-9 T 09-03-2017 IPR006657 Molybdopterin dinucleotide-binding domain GO:0016491|GO:0030151|GO:0055114 TK78_RS27635 c8d4e7832f5a6cd3a824ddca2a856a3d 764 Pfam PF00384 Molybdopterin oxidoreductase 120 489 1.8E-30 T 09-03-2017 IPR006656 Molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS34095 826582d78862d66bac63a4427db322e3 292 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 114 283 6.0E-18 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS34095 826582d78862d66bac63a4427db322e3 292 Gene3D G3DSA:1.10.3720.10 75 284 3.2E-39 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS34095 826582d78862d66bac63a4427db322e3 292 SUPERFAMILY SSF161098 76 269 4.06E-34 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS34095 826582d78862d66bac63a4427db322e3 292 TIGRFAM TIGR01726 HEQRo_perm_3TM: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family 75 178 1.3E-16 T 09-03-2017 IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain GO:0005215|GO:0006810|GO:0016021 TK78_RS34395 c8b0fb443c832a6274248174d470d7c8 212 ProSitePatterns PS01081 TetR-type HTH domain signature. 26 56 - T 09-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site TK78_RS34395 c8b0fb443c832a6274248174d470d7c8 212 Pfam PF00440 Bacterial regulatory proteins, tetR family 14 58 1.9E-15 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS34395 c8b0fb443c832a6274248174d470d7c8 212 SUPERFAMILY SSF46689 4 62 1.54E-16 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS34395 c8b0fb443c832a6274248174d470d7c8 212 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 35 58 7.3E-10 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS34395 c8b0fb443c832a6274248174d470d7c8 212 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 14 27 7.3E-10 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS34395 c8b0fb443c832a6274248174d470d7c8 212 Gene3D G3DSA:1.10.357.10 3 188 4.9E-29 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS34395 c8b0fb443c832a6274248174d470d7c8 212 SUPERFAMILY SSF48498 77 202 6.67E-24 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS17330 032d67c83e260038bb089f0953eb4ce1 357 Pfam PF13614 AAA domain 80 256 7.2E-57 T 09-03-2017 IPR025669 AAA domain TK78_RS17330 032d67c83e260038bb089f0953eb4ce1 357 Gene3D G3DSA:3.40.50.300 82 330 2.9E-72 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17330 032d67c83e260038bb089f0953eb4ce1 357 SUPERFAMILY SSF52540 80 329 4.0E-64 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS30295 ba26d3fe030bccc18bbfe22efa3a3285 194 Hamap MF_01219 Bifunctional protein PyrR [pyrR]. 12 185 36.952 T 09-03-2017 IPR023050 Bifunctional protein PyrR KEGG: 00240+2.4.2.9|MetaCyc: PWY-7183 TK78_RS30295 ba26d3fe030bccc18bbfe22efa3a3285 194 Pfam PF00156 Phosphoribosyl transferase domain 16 155 7.0E-20 T 09-03-2017 IPR000836 Phosphoribosyltransferase domain GO:0009116 TK78_RS30295 ba26d3fe030bccc18bbfe22efa3a3285 194 Gene3D G3DSA:3.40.50.2020 16 179 9.7E-49 T 09-03-2017 IPR029057 Phosphoribosyltransferase-like TK78_RS30295 ba26d3fe030bccc18bbfe22efa3a3285 194 SUPERFAMILY SSF53271 15 181 4.46E-40 T 09-03-2017 IPR029057 Phosphoribosyltransferase-like TK78_RS17760 39058a3bc5c77221fec2b259208268f0 274 TIGRFAM TIGR03083 TIGR03083: uncharacterized Actinobacterial protein TIGR03083 14 244 2.3E-37 T 09-03-2017 IPR017517 Conserved hypothetical protein CHP03083, actinobacterial-type TK78_RS17760 39058a3bc5c77221fec2b259208268f0 274 SUPERFAMILY SSF109854 3 159 7.02E-31 T 09-03-2017 TK78_RS17760 39058a3bc5c77221fec2b259208268f0 274 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 17 153 6.3E-19 T 09-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 TK78_RS17760 39058a3bc5c77221fec2b259208268f0 274 SUPERFAMILY SSF55718 204 268 7.06E-6 T 09-03-2017 IPR003033 SCP2 sterol-binding domain TK78_RS17760 39058a3bc5c77221fec2b259208268f0 274 Gene3D G3DSA:1.20.120.450 11 60 9.8E-9 T 09-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase TK78_RS17760 39058a3bc5c77221fec2b259208268f0 274 Pfam PF07398 MDMPI C-terminal domain 178 263 9.0E-10 T 09-03-2017 IPR010872 MDMPI C-terminal TK78_RS17760 39058a3bc5c77221fec2b259208268f0 274 Gene3D G3DSA:3.30.1050.10 191 266 5.5E-5 T 09-03-2017 IPR003033 SCP2 sterol-binding domain TK78_RS31575 b457675526bbc57f92b0f35c4570eae5 218 Pfam PF01810 LysE type translocator 15 213 2.8E-33 T 09-03-2017 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 TK78_RS31575 b457675526bbc57f92b0f35c4570eae5 218 PIRSF PIRSF006324 2 215 1.2E-49 T 09-03-2017 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 TK78_RS13350 80c8deaf296b1ec2e56d77ca6d77aa51 186 Gene3D G3DSA:1.10.10.10 97 179 2.1E-32 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS13350 80c8deaf296b1ec2e56d77ca6d77aa51 186 Pfam PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 99 179 7.6E-29 T 09-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 TK78_RS13350 80c8deaf296b1ec2e56d77ca6d77aa51 186 SUPERFAMILY SSF46767 97 179 1.31E-27 T 09-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 TK78_RS13350 80c8deaf296b1ec2e56d77ca6d77aa51 186 TIGRFAM TIGR00589 ogt: methylated-DNA--[protein]-cysteine S-methyltransferase 98 178 2.4E-30 T 09-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 TK78_RS13350 80c8deaf296b1ec2e56d77ca6d77aa51 186 SUPERFAMILY SSF53155 45 103 1.14E-7 T 09-03-2017 IPR008332 Methylguanine DNA methyltransferase, ribonuclease-like domain GO:0003908|GO:0006281 Reactome: R-HSA-5657655 TK78_RS12185 88c5fe60c7184608cb6d44fa32b1ca89 527 SUPERFAMILY SSF52540 16 237 3.25E-53 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS12185 88c5fe60c7184608cb6d44fa32b1ca89 527 ProSitePatterns PS00211 ABC transporters family signature. 416 430 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS12185 88c5fe60c7184608cb6d44fa32b1ca89 527 SUPERFAMILY SSF52540 265 502 3.97E-41 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS12185 88c5fe60c7184608cb6d44fa32b1ca89 527 Gene3D G3DSA:3.40.50.300 265 507 9.8E-46 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS12185 88c5fe60c7184608cb6d44fa32b1ca89 527 Gene3D G3DSA:3.40.50.300 14 242 1.7E-57 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS12185 88c5fe60c7184608cb6d44fa32b1ca89 527 Pfam PF00005 ABC transporter 34 179 1.3E-27 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS12185 88c5fe60c7184608cb6d44fa32b1ca89 527 Pfam PF00005 ABC transporter 288 443 1.0E-15 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS12185 88c5fe60c7184608cb6d44fa32b1ca89 527 SMART SM00382 42 227 5.0E-13 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS12185 88c5fe60c7184608cb6d44fa32b1ca89 527 SMART SM00382 296 492 4.4 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS07035 5bc875bf4080fef5b6fab656c0b26b06 431 SUPERFAMILY SSF53756 88 423 1.33E-66 T 09-03-2017 TK78_RS07035 5bc875bf4080fef5b6fab656c0b26b06 431 SUPERFAMILY SSF53756 1 58 1.33E-66 T 09-03-2017 TK78_RS07035 5bc875bf4080fef5b6fab656c0b26b06 431 Gene3D G3DSA:3.40.50.2000 1 259 6.3E-28 T 09-03-2017 TK78_RS07035 5bc875bf4080fef5b6fab656c0b26b06 431 Pfam PF06722 Protein of unknown function (DUF1205) 219 307 4.8E-17 T 09-03-2017 IPR010610 Domain of unknown function DUF1205 TK78_RS07035 5bc875bf4080fef5b6fab656c0b26b06 431 Gene3D G3DSA:3.40.50.2000 271 403 4.8E-18 T 09-03-2017 TK78_RS15290 27e8f15ff3fe629cd7cf9d693d0ba4c6 963 SMART SM00436 125 213 5.4E-45 T 09-03-2017 IPR003601 DNA topoisomerase, type IA, domain 2 GO:0003677|GO:0003916|GO:0006265 TK78_RS15290 27e8f15ff3fe629cd7cf9d693d0ba4c6 963 ProSitePatterns PS00396 Prokaryotic DNA topoisomerase I active site. 326 340 - T 09-03-2017 IPR023406 DNA topoisomerase, type IA, active site GO:0003917 TK78_RS15290 27e8f15ff3fe629cd7cf9d693d0ba4c6 963 SMART SM00493 12 125 2.1E-34 T 09-03-2017 IPR006171 Toprim domain TK78_RS15290 27e8f15ff3fe629cd7cf9d693d0ba4c6 963 Pfam PF01131 DNA topoisomerase 149 593 1.0E-129 T 09-03-2017 IPR013497 DNA topoisomerase, type IA, central GO:0003677|GO:0003916|GO:0006265 TK78_RS15290 27e8f15ff3fe629cd7cf9d693d0ba4c6 963 Pfam PF01751 Toprim domain 14 134 1.1E-26 T 09-03-2017 IPR006171 Toprim domain TK78_RS15290 27e8f15ff3fe629cd7cf9d693d0ba4c6 963 Pfam PF13368 Topoisomerase C-terminal repeat 840 892 8.2E-18 T 09-03-2017 IPR025589 Topoisomerase C-terminal repeat TK78_RS15290 27e8f15ff3fe629cd7cf9d693d0ba4c6 963 Pfam PF13368 Topoisomerase C-terminal repeat 777 827 1.6E-15 T 09-03-2017 IPR025589 Topoisomerase C-terminal repeat TK78_RS15290 27e8f15ff3fe629cd7cf9d693d0ba4c6 963 Pfam PF13368 Topoisomerase C-terminal repeat 707 771 6.5E-13 T 09-03-2017 IPR025589 Topoisomerase C-terminal repeat TK78_RS15290 27e8f15ff3fe629cd7cf9d693d0ba4c6 963 Pfam PF13368 Topoisomerase C-terminal repeat 648 699 2.0E-8 T 09-03-2017 IPR025589 Topoisomerase C-terminal repeat TK78_RS15290 27e8f15ff3fe629cd7cf9d693d0ba4c6 963 TIGRFAM TIGR01051 topA_bact: DNA topoisomerase I 14 668 2.6E-240 T 09-03-2017 IPR005733 DNA topoisomerase I, bacterial-type GO:0003677|GO:0003917|GO:0006265 TK78_RS15290 27e8f15ff3fe629cd7cf9d693d0ba4c6 963 Gene3D G3DSA:2.70.20.10 356 502 6.8E-35 T 09-03-2017 IPR013825 DNA topoisomerase, type IA, central region, subdomain 2 TK78_RS15290 27e8f15ff3fe629cd7cf9d693d0ba4c6 963 Gene3D G3DSA:2.70.20.10 205 355 1.6E-26 T 09-03-2017 IPR013825 DNA topoisomerase, type IA, central region, subdomain 2 TK78_RS15290 27e8f15ff3fe629cd7cf9d693d0ba4c6 963 SUPERFAMILY SSF56712 12 598 3.4E-178 T 09-03-2017 IPR023405 DNA topoisomerase, type IA, core domain TK78_RS15290 27e8f15ff3fe629cd7cf9d693d0ba4c6 963 Gene3D G3DSA:3.40.50.140 12 155 6.3E-48 T 09-03-2017 IPR006171 Toprim domain TK78_RS15290 27e8f15ff3fe629cd7cf9d693d0ba4c6 963 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 183 201 1.1E-33 T 09-03-2017 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 TK78_RS15290 27e8f15ff3fe629cd7cf9d693d0ba4c6 963 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 519 533 1.1E-33 T 09-03-2017 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 TK78_RS15290 27e8f15ff3fe629cd7cf9d693d0ba4c6 963 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 331 340 1.1E-33 T 09-03-2017 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 TK78_RS15290 27e8f15ff3fe629cd7cf9d693d0ba4c6 963 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 408 424 1.1E-33 T 09-03-2017 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 TK78_RS15290 27e8f15ff3fe629cd7cf9d693d0ba4c6 963 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 99 112 1.1E-33 T 09-03-2017 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 TK78_RS15290 27e8f15ff3fe629cd7cf9d693d0ba4c6 963 Hamap MF_00952 DNA topoisomerase 1 [topA]. 12 786 54.817 T 09-03-2017 IPR028612 DNA topoisomerase I, type IA GO:0003677|GO:0003916|GO:0006265 TK78_RS15290 27e8f15ff3fe629cd7cf9d693d0ba4c6 963 SMART SM00437 289 556 7.4E-121 T 09-03-2017 IPR003602 DNA topoisomerase, type IA, DNA-binding domain GO:0003677|GO:0003916|GO:0006265 TK78_RS15290 27e8f15ff3fe629cd7cf9d693d0ba4c6 963 Gene3D G3DSA:1.10.460.10 156 203 1.5E-50 T 09-03-2017 IPR013824 DNA topoisomerase, type IA, central region, subdomain 1 TK78_RS15290 27e8f15ff3fe629cd7cf9d693d0ba4c6 963 Gene3D G3DSA:1.10.460.10 503 597 1.5E-50 T 09-03-2017 IPR013824 DNA topoisomerase, type IA, central region, subdomain 1 TK78_RS09470 8a6e436b83357838ec9bc5f169f6ac79 349 ProSitePatterns PS00655 Glycosyl hydrolases family 6 signature 1. 126 142 - T 09-03-2017 IPR001524 Glycoside hydrolase, family 6, conserved site GO:0004553|GO:0005975 TK78_RS09470 8a6e436b83357838ec9bc5f169f6ac79 349 Pfam PF01341 Glycosyl hydrolases family 6 67 329 9.3E-84 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS09470 8a6e436b83357838ec9bc5f169f6ac79 349 SUPERFAMILY SSF51989 54 347 5.63E-88 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS09470 8a6e436b83357838ec9bc5f169f6ac79 349 PRINTS PR00733 Glycosyl hydrolase family 6 signature 267 280 9.3E-39 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS09470 8a6e436b83357838ec9bc5f169f6ac79 349 PRINTS PR00733 Glycosyl hydrolase family 6 signature 121 134 9.3E-39 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS09470 8a6e436b83357838ec9bc5f169f6ac79 349 PRINTS PR00733 Glycosyl hydrolase family 6 signature 286 306 9.3E-39 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS09470 8a6e436b83357838ec9bc5f169f6ac79 349 PRINTS PR00733 Glycosyl hydrolase family 6 signature 149 164 9.3E-39 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS09470 8a6e436b83357838ec9bc5f169f6ac79 349 PRINTS PR00733 Glycosyl hydrolase family 6 signature 310 324 9.3E-39 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS09470 8a6e436b83357838ec9bc5f169f6ac79 349 PRINTS PR00733 Glycosyl hydrolase family 6 signature 237 247 9.3E-39 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS09470 8a6e436b83357838ec9bc5f169f6ac79 349 PRINTS PR00733 Glycosyl hydrolase family 6 signature 206 219 9.3E-39 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS09470 8a6e436b83357838ec9bc5f169f6ac79 349 PIRSF PIRSF001100 8 349 1.2E-95 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS09470 8a6e436b83357838ec9bc5f169f6ac79 349 Gene3D G3DSA:3.20.20.40 60 347 1.7E-96 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS32020 a39c7e4cc49321d174afbb51361d2b1c 503 Pfam PF14033 Protein of unknown function (DUF4246) 24 462 3.4E-133 T 09-03-2017 IPR025340 Protein of unknown function DUF4246 TK78_RS27710 35db75c2a148c7ddfa2b01299cd715ea 232 Pfam PF08241 Methyltransferase domain 51 140 2.0E-12 T 09-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 TK78_RS27710 35db75c2a148c7ddfa2b01299cd715ea 232 SUPERFAMILY SSF53335 35 226 4.71E-24 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS27710 35db75c2a148c7ddfa2b01299cd715ea 232 Gene3D G3DSA:3.40.50.150 39 218 3.2E-22 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS29350 c70c8de9a75b4298083604e666dcd156 72 TIGRFAM TIGR03687 pupylate_cterm: ubiquitin-like protein Pup 41 72 4.6E-21 T 09-03-2017 IPR008515 Ubiquitin-like, Pup TK78_RS29350 c70c8de9a75b4298083604e666dcd156 72 Hamap MF_02106 Prokaryotic ubiquitin-like protein Pup [pup]. 1 72 18.049 T 09-03-2017 IPR008515 Ubiquitin-like, Pup TK78_RS29350 c70c8de9a75b4298083604e666dcd156 72 Pfam PF05639 Pup-like protein 4 72 1.7E-30 T 09-03-2017 IPR008515 Ubiquitin-like, Pup TK78_RS27680 2f195f8ee02c77168b40ed3a0ae4bdcc 312 SUPERFAMILY SSF159659 25 276 1.14E-71 T 09-03-2017 TK78_RS27680 2f195f8ee02c77168b40ed3a0ae4bdcc 312 Gene3D G3DSA:1.10.287.100 237 275 5.7E-8 T 09-03-2017 IPR013028 Transcription factor IIA, alpha subunit, N-terminal GO:0006367 TK78_RS27680 2f195f8ee02c77168b40ed3a0ae4bdcc 312 PIRSF PIRSF028754 12 312 8.1E-109 T 09-03-2017 IPR008492 Protein of unknown function DUF774 TK78_RS27680 2f195f8ee02c77168b40ed3a0ae4bdcc 312 Pfam PF09754 PAC2 family 35 253 2.7E-37 T 09-03-2017 IPR019151 Proteasome assembly chaperone 2 TK78_RS33665 e148e38ebe0fb588f53b7227de2b4961 353 SUPERFAMILY SSF81345 20 349 2.62E-68 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS33665 e148e38ebe0fb588f53b7227de2b4961 353 Gene3D G3DSA:1.10.3470.10 28 351 1.9E-86 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS33665 e148e38ebe0fb588f53b7227de2b4961 353 Pfam PF01032 FecCD transport family 39 349 4.0E-83 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS16325 36a82fe1ca010a24419d4cf5efd19b25 375 Pfam PF00067 Cytochrome P450 252 350 1.9E-17 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS16325 36a82fe1ca010a24419d4cf5efd19b25 375 PRINTS PR00385 P450 superfamily signature 219 236 1.7E-6 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS16325 36a82fe1ca010a24419d4cf5efd19b25 375 PRINTS PR00385 P450 superfamily signature 318 327 1.7E-6 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS16325 36a82fe1ca010a24419d4cf5efd19b25 375 PRINTS PR00385 P450 superfamily signature 327 338 1.7E-6 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS16325 36a82fe1ca010a24419d4cf5efd19b25 375 PRINTS PR00385 P450 superfamily signature 253 264 1.7E-6 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS16325 36a82fe1ca010a24419d4cf5efd19b25 375 SUPERFAMILY SSF48264 5 373 3.67E-66 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS16325 36a82fe1ca010a24419d4cf5efd19b25 375 Gene3D G3DSA:1.10.630.10 4 375 5.0E-84 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS16325 36a82fe1ca010a24419d4cf5efd19b25 375 PRINTS PR00359 B-class P450 signature 170 192 4.1E-40 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS16325 36a82fe1ca010a24419d4cf5efd19b25 375 PRINTS PR00359 B-class P450 signature 253 264 4.1E-40 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS16325 36a82fe1ca010a24419d4cf5efd19b25 375 PRINTS PR00359 B-class P450 signature 110 126 4.1E-40 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS16325 36a82fe1ca010a24419d4cf5efd19b25 375 PRINTS PR00359 B-class P450 signature 61 72 4.1E-40 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS16325 36a82fe1ca010a24419d4cf5efd19b25 375 PRINTS PR00359 B-class P450 signature 127 142 4.1E-40 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS16325 36a82fe1ca010a24419d4cf5efd19b25 375 PRINTS PR00359 B-class P450 signature 298 313 4.1E-40 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS16325 36a82fe1ca010a24419d4cf5efd19b25 375 PRINTS PR00359 B-class P450 signature 327 338 4.1E-40 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS16325 36a82fe1ca010a24419d4cf5efd19b25 375 PRINTS PR00359 B-class P450 signature 318 327 4.1E-40 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS16325 36a82fe1ca010a24419d4cf5efd19b25 375 PRINTS PR00359 B-class P450 signature 270 297 4.1E-40 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS16325 36a82fe1ca010a24419d4cf5efd19b25 375 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 320 329 - T 09-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 TK78_RS05335 2baa27b5f489695856107ca3c9478e48 330 SMART SM00421 260 317 2.4E-7 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS05335 2baa27b5f489695856107ca3c9478e48 330 SUPERFAMILY SSF46785 10 65 7.28E-6 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05335 2baa27b5f489695856107ca3c9478e48 330 Gene3D G3DSA:1.10.10.10 267 323 3.1E-9 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05335 2baa27b5f489695856107ca3c9478e48 330 SUPERFAMILY SSF46894 265 323 2.96E-9 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS05335 2baa27b5f489695856107ca3c9478e48 330 Pfam PF01978 Sugar-specific transcriptional regulator TrmB 4 68 6.6E-9 T 09-03-2017 IPR002831 Transcription regulator TrmB, N-terminal TK78_RS05335 2baa27b5f489695856107ca3c9478e48 330 Gene3D G3DSA:1.10.10.10 2 64 6.5E-7 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS33625 718938c6dba38398a859cd84be4d549c 276 Pfam PF13649 Methyltransferase domain 81 117 7.4E-7 T 09-03-2017 TK78_RS33625 718938c6dba38398a859cd84be4d549c 276 Gene3D G3DSA:3.40.50.150 77 180 1.4E-13 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS33625 718938c6dba38398a859cd84be4d549c 276 SUPERFAMILY SSF53335 77 230 3.01E-14 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS29820 f16fdf8b4d65db318c5b684f56b1cbc0 178 SUPERFAMILY SSF46785 16 85 6.25E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS29820 f16fdf8b4d65db318c5b684f56b1cbc0 178 SUPERFAMILY SSF55252 107 172 1.7E-18 T 09-03-2017 IPR020899 Arginine repressor, C-terminal GO:0034618|GO:0051259 TK78_RS29820 f16fdf8b4d65db318c5b684f56b1cbc0 178 TIGRFAM TIGR01529 argR_whole: arginine repressor 20 173 1.8E-43 T 09-03-2017 IPR001669 Arginine repressor GO:0003700|GO:0006355 TK78_RS29820 f16fdf8b4d65db318c5b684f56b1cbc0 178 PRINTS PR01467 Bacterial arginine repressor signature 143 158 2.3E-26 T 09-03-2017 IPR001669 Arginine repressor GO:0003700|GO:0006355 TK78_RS29820 f16fdf8b4d65db318c5b684f56b1cbc0 178 PRINTS PR01467 Bacterial arginine repressor signature 113 126 2.3E-26 T 09-03-2017 IPR001669 Arginine repressor GO:0003700|GO:0006355 TK78_RS29820 f16fdf8b4d65db318c5b684f56b1cbc0 178 PRINTS PR01467 Bacterial arginine repressor signature 36 49 2.3E-26 T 09-03-2017 IPR001669 Arginine repressor GO:0003700|GO:0006355 TK78_RS29820 f16fdf8b4d65db318c5b684f56b1cbc0 178 PRINTS PR01467 Bacterial arginine repressor signature 52 67 2.3E-26 T 09-03-2017 IPR001669 Arginine repressor GO:0003700|GO:0006355 TK78_RS29820 f16fdf8b4d65db318c5b684f56b1cbc0 178 Pfam PF01316 Arginine repressor, DNA binding domain 17 84 5.3E-25 T 09-03-2017 IPR020900 Arginine repressor, DNA-binding domain GO:0003700|GO:0006355|GO:0006525 TK78_RS29820 f16fdf8b4d65db318c5b684f56b1cbc0 178 Gene3D G3DSA:1.10.10.10 14 87 8.1E-28 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS29820 f16fdf8b4d65db318c5b684f56b1cbc0 178 Pfam PF02863 Arginine repressor, C-terminal domain 107 170 1.5E-23 T 09-03-2017 IPR020899 Arginine repressor, C-terminal GO:0034618|GO:0051259 TK78_RS29820 f16fdf8b4d65db318c5b684f56b1cbc0 178 ProDom PD007402 ARGININE REPRESSOR TRANSCRIPTION BIOSYNTHESIS DNA-BINDING REGULATION AMINO-ACID ARGR TRANSCRIPTIONAL FAMILY 119 152 4.0E-12 T 09-03-2017 IPR020899 Arginine repressor, C-terminal GO:0034618|GO:0051259 TK78_RS29820 f16fdf8b4d65db318c5b684f56b1cbc0 178 Hamap MF_00173 Arginine repressor [argR]. 1 177 57.076 T 09-03-2017 IPR001669 Arginine repressor GO:0003700|GO:0006355 TK78_RS29820 f16fdf8b4d65db318c5b684f56b1cbc0 178 Gene3D G3DSA:3.30.1360.40 98 173 2.0E-28 T 09-03-2017 IPR024946 Arginine repressor C-terminal-like domain TK78_RS00725 549bbd99f458e9e9fb8de8f86ba44e5c 169 Gene3D G3DSA:1.20.120.450 3 168 1.0E-44 T 09-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase TK78_RS00725 549bbd99f458e9e9fb8de8f86ba44e5c 169 SUPERFAMILY SSF109854 4 164 1.21E-39 T 09-03-2017 TK78_RS00725 549bbd99f458e9e9fb8de8f86ba44e5c 169 Pfam PF04978 Protein of unknown function (DUF664) 17 165 4.8E-42 T 09-03-2017 IPR007061 Protein of unknown function DUF664 TK78_RS08485 b6656423b4da076b399556e7a5a5280d 408 Pfam PF16483 Beta-1,3-glucanase 37 406 6.4E-114 T 09-03-2017 IPR032477 Beta-1,3-glucanase, N-terminal KEGG: 00500+3.2.1.39 TK78_RS01130 bc5eb71570d15040fa7d77890ad83c30 341 Gene3D G3DSA:3.20.20.80 52 329 4.0E-58 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS01130 bc5eb71570d15040fa7d77890ad83c30 341 Pfam PF00704 Glycosyl hydrolases family 18 54 322 1.3E-27 T 09-03-2017 IPR001223 Glycoside hydrolase family 18, catalytic domain GO:0004553|GO:0005975 TK78_RS01130 bc5eb71570d15040fa7d77890ad83c30 341 ProSitePatterns PS01095 Chitinases family 18 active site. 159 167 - T 09-03-2017 IPR001579 Glycoside hydrolase, chitinase active site GO:0004553|GO:0005975 KEGG: 00520+3.2.1.14|MetaCyc: PWY-6902 TK78_RS01130 bc5eb71570d15040fa7d77890ad83c30 341 SUPERFAMILY SSF51445 50 330 2.52E-53 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS01130 bc5eb71570d15040fa7d77890ad83c30 341 SMART SM00636 52 322 6.5E-7 T 09-03-2017 IPR011583 Chitinase II GO:0004568|GO:0006032 TK78_RS00765 8b2f1c20ce81568dd4f01c8b538a0eb9 509 SUPERFAMILY SSF53850 33 499 7.42E-81 T 09-03-2017 TK78_RS00765 8b2f1c20ce81568dd4f01c8b538a0eb9 509 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 76 415 7.1E-56 T 09-03-2017 IPR000914 Solute-binding protein family 5 domain TK78_RS00765 8b2f1c20ce81568dd4f01c8b538a0eb9 509 Gene3D G3DSA:3.40.190.10 185 294 1.6E-20 T 09-03-2017 TK78_RS00765 8b2f1c20ce81568dd4f01c8b538a0eb9 509 Gene3D G3DSA:3.10.105.10 295 477 5.3E-27 T 09-03-2017 TK78_RS00765 8b2f1c20ce81568dd4f01c8b538a0eb9 509 PIRSF PIRSF002741 2 505 1.8E-55 T 09-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 TK78_RS00765 8b2f1c20ce81568dd4f01c8b538a0eb9 509 Gene3D G3DSA:3.90.76.10 44 184 1.1E-27 T 09-03-2017 TK78_RS16090 057c2e2d33e9e66b004145567e4b70be 217 Hamap MF_01151 Protein GrpE [grpE]. 3 190 17.416 T 09-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 TK78_RS16090 057c2e2d33e9e66b004145567e4b70be 217 Pfam PF01025 GrpE 42 190 1.4E-35 T 09-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 TK78_RS16090 057c2e2d33e9e66b004145567e4b70be 217 SUPERFAMILY SSF51064 136 191 4.32E-16 T 09-03-2017 IPR009012 GrpE nucleotide exchange factor, head GO:0006457 Reactome: R-HSA-1268020 TK78_RS16090 057c2e2d33e9e66b004145567e4b70be 217 Gene3D G3DSA:3.90.20.20 47 133 4.9E-20 T 09-03-2017 IPR013805 GrpE nucleotide exchange factor, coiled-coil Reactome: R-HSA-1268020 TK78_RS16090 057c2e2d33e9e66b004145567e4b70be 217 SUPERFAMILY SSF58014 48 134 6.41E-18 T 09-03-2017 TK78_RS16090 057c2e2d33e9e66b004145567e4b70be 217 Gene3D G3DSA:2.30.22.10 134 191 3.6E-22 T 09-03-2017 IPR009012 GrpE nucleotide exchange factor, head GO:0006457 Reactome: R-HSA-1268020 TK78_RS16090 057c2e2d33e9e66b004145567e4b70be 217 PRINTS PR00773 GrpE protein signature 67 83 2.4E-25 T 09-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 TK78_RS16090 057c2e2d33e9e66b004145567e4b70be 217 PRINTS PR00773 GrpE protein signature 142 157 2.4E-25 T 09-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 TK78_RS16090 057c2e2d33e9e66b004145567e4b70be 217 PRINTS PR00773 GrpE protein signature 95 110 2.4E-25 T 09-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 TK78_RS16090 057c2e2d33e9e66b004145567e4b70be 217 PRINTS PR00773 GrpE protein signature 169 188 2.4E-25 T 09-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 TK78_RS16090 057c2e2d33e9e66b004145567e4b70be 217 ProSitePatterns PS01071 grpE protein signature. 145 188 - T 09-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 TK78_RS17510 6bf5292ce5f13096182e7b9e53aad0e5 662 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 17 40 - T 09-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 TK78_RS17510 6bf5292ce5f13096182e7b9e53aad0e5 662 SMART SM00740 580 644 7.2E-5 T 09-03-2017 IPR005543 PASTA domain TK78_RS17510 6bf5292ce5f13096182e7b9e53aad0e5 662 SMART SM00740 377 444 1.9E-10 T 09-03-2017 IPR005543 PASTA domain TK78_RS17510 6bf5292ce5f13096182e7b9e53aad0e5 662 SMART SM00740 445 510 2.2E-15 T 09-03-2017 IPR005543 PASTA domain TK78_RS17510 6bf5292ce5f13096182e7b9e53aad0e5 662 SMART SM00740 511 576 9.3E-7 T 09-03-2017 IPR005543 PASTA domain TK78_RS17510 6bf5292ce5f13096182e7b9e53aad0e5 662 SUPERFAMILY SSF56112 7 273 1.48E-77 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS17510 6bf5292ce5f13096182e7b9e53aad0e5 662 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 134 146 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS17510 6bf5292ce5f13096182e7b9e53aad0e5 662 Pfam PF03793 PASTA domain 584 642 2.4E-6 T 09-03-2017 IPR005543 PASTA domain TK78_RS17510 6bf5292ce5f13096182e7b9e53aad0e5 662 Pfam PF03793 PASTA domain 381 443 1.4E-10 T 09-03-2017 IPR005543 PASTA domain TK78_RS17510 6bf5292ce5f13096182e7b9e53aad0e5 662 Pfam PF03793 PASTA domain 449 510 3.1E-12 T 09-03-2017 IPR005543 PASTA domain TK78_RS17510 6bf5292ce5f13096182e7b9e53aad0e5 662 Pfam PF03793 PASTA domain 516 576 6.0E-9 T 09-03-2017 IPR005543 PASTA domain TK78_RS17510 6bf5292ce5f13096182e7b9e53aad0e5 662 SMART SM00220 11 277 3.3E-68 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS17510 6bf5292ce5f13096182e7b9e53aad0e5 662 Gene3D G3DSA:1.10.510.10 98 274 4.5E-49 T 09-03-2017 TK78_RS17510 6bf5292ce5f13096182e7b9e53aad0e5 662 Pfam PF00069 Protein kinase domain 11 265 7.6E-51 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS17510 6bf5292ce5f13096182e7b9e53aad0e5 662 Gene3D G3DSA:3.30.200.20 4 94 4.1E-30 T 09-03-2017 TK78_RS04675 5a1ee1ec282b453ba4beaf0e1cc6d65b 466 Gene3D G3DSA:3.20.20.140 74 381 6.3E-116 T 09-03-2017 TK78_RS04675 5a1ee1ec282b453ba4beaf0e1cc6d65b 466 SUPERFAMILY SSF51338 3 70 3.13E-9 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS04675 5a1ee1ec282b453ba4beaf0e1cc6d65b 466 SUPERFAMILY SSF51338 361 461 5.35E-34 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS04675 5a1ee1ec282b453ba4beaf0e1cc6d65b 466 Gene3D G3DSA:2.30.40.10 3 73 2.8E-27 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS04675 5a1ee1ec282b453ba4beaf0e1cc6d65b 466 Gene3D G3DSA:2.30.40.10 382 458 1.5E-14 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS04675 5a1ee1ec282b453ba4beaf0e1cc6d65b 466 TIGRFAM TIGR02033 D-hydantoinase: dihydropyrimidinase 5 458 3.4E-171 T 09-03-2017 IPR011778 Hydantoinase/dihydropyrimidinase GO:0005737 Reactome: R-HSA-399956 TK78_RS04675 5a1ee1ec282b453ba4beaf0e1cc6d65b 466 SUPERFAMILY SSF51556 59 387 2.55E-106 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS04675 5a1ee1ec282b453ba4beaf0e1cc6d65b 466 Pfam PF01979 Amidohydrolase family 55 441 1.7E-25 T 09-03-2017 IPR006680 Amidohydrolase-related GO:0016787 TK78_RS21970 c94c7ee483730791c2d6629b1e31529c 87 Pfam PF02467 Transcription factor WhiB 19 82 4.8E-27 T 09-03-2017 IPR003482 Transcription factor WhiB TK78_RS21970 c94c7ee483730791c2d6629b1e31529c 87 Hamap MF_01479 Transcriptional regulator WhiB [whiB]. 1 87 18.763 T 09-03-2017 IPR003482 Transcription factor WhiB TK78_RS04010 372a12bcd3cd56cd00ab67d641f345b2 336 Pfam PF12833 Helix-turn-helix domain 231 308 1.5E-20 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS04010 372a12bcd3cd56cd00ab67d641f345b2 336 SUPERFAMILY SSF46689 261 310 3.4E-11 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS04010 372a12bcd3cd56cd00ab67d641f345b2 336 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 292 308 8.2E-5 T 09-03-2017 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 TK78_RS04010 372a12bcd3cd56cd00ab67d641f345b2 336 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 277 292 8.2E-5 T 09-03-2017 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 TK78_RS04010 372a12bcd3cd56cd00ab67d641f345b2 336 SMART SM00342 225 308 8.5E-30 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS04010 372a12bcd3cd56cd00ab67d641f345b2 336 Gene3D G3DSA:1.10.10.60 207 262 1.4E-12 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS04010 372a12bcd3cd56cd00ab67d641f345b2 336 Gene3D G3DSA:1.10.10.60 263 312 6.6E-15 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS04010 372a12bcd3cd56cd00ab67d641f345b2 336 Pfam PF12852 Cupin 2 193 4.5E-51 T 09-03-2017 IPR032783 AraC-type transcription regulator, ligand-binding domain TK78_RS04010 372a12bcd3cd56cd00ab67d641f345b2 336 SUPERFAMILY SSF46689 208 259 1.77E-8 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS04010 372a12bcd3cd56cd00ab67d641f345b2 336 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 262 304 - T 09-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 TK78_RS01105 982036b6c2822ee3ac2f86e842bc79e5 144 Pfam PF00011 Hsp20/alpha crystallin family 35 132 2.1E-19 T 09-03-2017 IPR002068 Alpha crystallin/Hsp20 domain TK78_RS01105 982036b6c2822ee3ac2f86e842bc79e5 144 Gene3D G3DSA:2.60.40.790 6 132 5.5E-29 T 09-03-2017 IPR008978 HSP20-like chaperone TK78_RS01105 982036b6c2822ee3ac2f86e842bc79e5 144 SUPERFAMILY SSF49764 15 132 4.88E-29 T 09-03-2017 IPR008978 HSP20-like chaperone TK78_RS25465 d1a4a4d3a6e0166aa1d16e8c78e295d2 305 SUPERFAMILY SSF52151 179 302 6.02E-64 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS25465 d1a4a4d3a6e0166aa1d16e8c78e295d2 305 SUPERFAMILY SSF52151 2 116 6.02E-64 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS25465 d1a4a4d3a6e0166aa1d16e8c78e295d2 305 Gene3D G3DSA:3.30.70.250 120 185 1.6E-20 T 09-03-2017 TK78_RS25465 d1a4a4d3a6e0166aa1d16e8c78e295d2 305 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 5 305 5.6E-18 T 09-03-2017 IPR020801 Polyketide synthase, acyl transferase domain TK78_RS25465 d1a4a4d3a6e0166aa1d16e8c78e295d2 305 Gene3D G3DSA:3.40.366.10 186 293 4.2E-52 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS25465 d1a4a4d3a6e0166aa1d16e8c78e295d2 305 Gene3D G3DSA:3.40.366.10 2 116 4.2E-52 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS25465 d1a4a4d3a6e0166aa1d16e8c78e295d2 305 SUPERFAMILY SSF55048 124 177 4.58E-10 T 09-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 TK78_RS25465 d1a4a4d3a6e0166aa1d16e8c78e295d2 305 Pfam PF00698 Acyl transferase domain 5 278 2.9E-20 T 09-03-2017 IPR014043 Acyl transferase TK78_RS14740 f0ee755cb5248c0d4370ed88f226a798 272 Gene3D G3DSA:3.40.50.720 2 240 4.8E-50 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS14740 f0ee755cb5248c0d4370ed88f226a798 272 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 187 204 3.9E-14 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS14740 f0ee755cb5248c0d4370ed88f226a798 272 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 166 185 3.9E-14 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS14740 f0ee755cb5248c0d4370ed88f226a798 272 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 130 146 3.9E-14 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS14740 f0ee755cb5248c0d4370ed88f226a798 272 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 81 92 3.9E-14 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS14740 f0ee755cb5248c0d4370ed88f226a798 272 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 5 22 3.9E-14 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS14740 f0ee755cb5248c0d4370ed88f226a798 272 SUPERFAMILY SSF51735 2 240 1.28E-46 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS14740 f0ee755cb5248c0d4370ed88f226a798 272 Pfam PF00106 short chain dehydrogenase 5 199 6.8E-29 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS08215 e435db805b2d3c5793f294baed57b6e8 404 SMART SM00962 204 403 2.2E-103 T 09-03-2017 IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain GO:0005525|GO:0006614 Reactome: R-HSA-1799339 TK78_RS08215 e435db805b2d3c5793f294baed57b6e8 404 Hamap MF_00920 Signal recognition particle receptor FtsY [ftsY]. 130 403 58.785 T 09-03-2017 IPR004390 Signal-recognition particle receptor FtsY GO:0006614 TK78_RS08215 e435db805b2d3c5793f294baed57b6e8 404 TIGRFAM TIGR00064 ftsY: signal recognition particle-docking protein FtsY 131 401 1.6E-101 T 09-03-2017 IPR004390 Signal-recognition particle receptor FtsY GO:0006614 TK78_RS08215 e435db805b2d3c5793f294baed57b6e8 404 SMART SM00382 203 379 4.8E-9 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS08215 e435db805b2d3c5793f294baed57b6e8 404 SUPERFAMILY SSF47364 103 181 4.06E-19 T 09-03-2017 IPR013822 Signal recognition particle, SRP54 subunit, helical bundle GO:0005525|GO:0006614 Reactome: R-HSA-1799339 TK78_RS08215 e435db805b2d3c5793f294baed57b6e8 404 Gene3D G3DSA:1.20.120.140 132 215 6.4E-28 T 09-03-2017 TK78_RS08215 e435db805b2d3c5793f294baed57b6e8 404 SUPERFAMILY SSF52540 203 402 9.11E-49 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08215 e435db805b2d3c5793f294baed57b6e8 404 ProSitePatterns PS00300 SRP54-type proteins GTP-binding domain signature. 376 389 - T 09-03-2017 IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain GO:0005525|GO:0006614 Reactome: R-HSA-1799339 TK78_RS08215 e435db805b2d3c5793f294baed57b6e8 404 SMART SM00963 107 187 4.5E-24 T 09-03-2017 IPR013822 Signal recognition particle, SRP54 subunit, helical bundle GO:0005525|GO:0006614 Reactome: R-HSA-1799339 TK78_RS08215 e435db805b2d3c5793f294baed57b6e8 404 Gene3D G3DSA:3.40.50.300 216 403 2.3E-72 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08215 e435db805b2d3c5793f294baed57b6e8 404 Pfam PF02881 SRP54-type protein, helical bundle domain 118 183 2.9E-13 T 09-03-2017 IPR013822 Signal recognition particle, SRP54 subunit, helical bundle GO:0005525|GO:0006614 Reactome: R-HSA-1799339 TK78_RS08215 e435db805b2d3c5793f294baed57b6e8 404 Pfam PF00448 SRP54-type protein, GTPase domain 205 402 5.4E-72 T 09-03-2017 IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain GO:0005525|GO:0006614 Reactome: R-HSA-1799339 TK78_RS26460 91bc36333972ff79af1ad41f66a837a4 344 SUPERFAMILY SSF55931 91 339 2.84E-63 T 09-03-2017 TK78_RS26460 91bc36333972ff79af1ad41f66a837a4 344 Pfam PF03951 Glutamine synthetase, beta-Grasp domain 5 83 1.5E-14 T 09-03-2017 IPR008147 Glutamine synthetase, beta-Grasp domain GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 TK78_RS26460 91bc36333972ff79af1ad41f66a837a4 344 SUPERFAMILY SSF54368 6 90 8.5E-13 T 09-03-2017 IPR008147 Glutamine synthetase, beta-Grasp domain GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 TK78_RS26460 91bc36333972ff79af1ad41f66a837a4 344 Pfam PF00120 Glutamine synthetase, catalytic domain 94 237 1.8E-11 T 09-03-2017 IPR008146 Glutamine synthetase, catalytic domain GO:0004356|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 TK78_RS26460 91bc36333972ff79af1ad41f66a837a4 344 ProSitePatterns PS00180 Glutamine synthetase signature 1. 42 59 - T 09-03-2017 IPR027302 Glutamine synthetase, N-terminal conserved site KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964|Reactome: R-HSA-210455|Reactome: R-HSA-70614 TK78_RS26460 91bc36333972ff79af1ad41f66a837a4 344 Gene3D G3DSA:3.30.590.10 94 340 3.8E-53 T 09-03-2017 IPR014746 Glutamine synthetase/guanido kinase, catalytic domain GO:0003824 TK78_RS26460 91bc36333972ff79af1ad41f66a837a4 344 ProSitePatterns PS00181 Glutamine synthetase putative ATP-binding region signature. 220 236 - T 09-03-2017 IPR027303 Glutamine synthetase, glycine-rich site KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964|Reactome: R-HSA-210455|Reactome: R-HSA-70614 TK78_RS26460 91bc36333972ff79af1ad41f66a837a4 344 SMART SM01230 90 334 3.5E-49 T 09-03-2017 IPR008146 Glutamine synthetase, catalytic domain GO:0004356|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 TK78_RS01900 5043ba2dddf57a5fd2b6f5d93016698c 419 Pfam PF07690 Major Facilitator Superfamily 8 327 5.7E-23 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS01900 5043ba2dddf57a5fd2b6f5d93016698c 419 SUPERFAMILY SSF103473 4 400 2.88E-40 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS01900 5043ba2dddf57a5fd2b6f5d93016698c 419 Gene3D G3DSA:1.20.1250.20 215 404 9.6E-12 T 09-03-2017 TK78_RS01900 5043ba2dddf57a5fd2b6f5d93016698c 419 Gene3D G3DSA:1.20.1250.20 2 189 3.1E-22 T 09-03-2017 TK78_RS09855 d503d83dce81fd1409c9efab1614fa77 350 Pfam PF02735 Ku70/Ku80 beta-barrel domain 11 178 3.2E-32 T 09-03-2017 IPR006164 Ku70/Ku80 beta-barrel domain GO:0003677|GO:0006303 Reactome: R-HSA-164843|Reactome: R-HSA-1834949|Reactome: R-HSA-3270619|Reactome: R-HSA-5693571 TK78_RS09855 d503d83dce81fd1409c9efab1614fa77 350 Hamap MF_01875 Non-homologous end joining protein Ku [ku]. 1 253 29.765 T 09-03-2017 IPR009187 Non-homologous end joining protein Ku, prokaryotic type TK78_RS09855 d503d83dce81fd1409c9efab1614fa77 350 SUPERFAMILY SSF100939 2 258 1.47E-46 T 09-03-2017 IPR016194 SPOC-like, C-terminal domain TK78_RS09855 d503d83dce81fd1409c9efab1614fa77 350 Gene3D G3DSA:2.40.290.10 4 147 1.1E-9 T 09-03-2017 IPR016194 SPOC-like, C-terminal domain TK78_RS09855 d503d83dce81fd1409c9efab1614fa77 350 SMART SM00559 52 181 2.5E-44 T 09-03-2017 IPR006164 Ku70/Ku80 beta-barrel domain GO:0003677|GO:0006303 Reactome: R-HSA-164843|Reactome: R-HSA-1834949|Reactome: R-HSA-3270619|Reactome: R-HSA-5693571 TK78_RS09855 d503d83dce81fd1409c9efab1614fa77 350 TIGRFAM TIGR02772 Ku_bact: Ku protein 2 256 8.5E-85 T 09-03-2017 IPR009187 Non-homologous end joining protein Ku, prokaryotic type TK78_RS08540 787ddeef28f7ba0a81b4c811cc8fb68f 202 SUPERFAMILY SSF55729 13 197 1.51E-19 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS08540 787ddeef28f7ba0a81b4c811cc8fb68f 202 Gene3D G3DSA:3.40.630.30 12 200 9.0E-41 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS08540 787ddeef28f7ba0a81b4c811cc8fb68f 202 Pfam PF00583 Acetyltransferase (GNAT) family 120 178 2.2E-8 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS24440 a454e7e63d063c5497696c1f892743bf 137 Gene3D G3DSA:3.30.70.141 2 134 5.2E-54 T 09-03-2017 TK78_RS24440 a454e7e63d063c5497696c1f892743bf 137 SMART SM00562 2 137 1.2E-73 T 09-03-2017 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 TK78_RS24440 a454e7e63d063c5497696c1f892743bf 137 SUPERFAMILY SSF54919 1 135 5.5E-51 T 09-03-2017 TK78_RS24440 a454e7e63d063c5497696c1f892743bf 137 Pfam PF00334 Nucleoside diphosphate kinase 3 134 7.9E-51 T 09-03-2017 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 TK78_RS24440 a454e7e63d063c5497696c1f892743bf 137 Hamap MF_00451 Nucleoside diphosphate kinase [ndk]. 2 136 32.327 T 09-03-2017 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 TK78_RS24440 a454e7e63d063c5497696c1f892743bf 137 PRINTS PR01243 Nucleoside diphosphate kinase signature 5 27 5.4E-43 T 09-03-2017 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 TK78_RS24440 a454e7e63d063c5497696c1f892743bf 137 PRINTS PR01243 Nucleoside diphosphate kinase signature 50 69 5.4E-43 T 09-03-2017 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 TK78_RS24440 a454e7e63d063c5497696c1f892743bf 137 PRINTS PR01243 Nucleoside diphosphate kinase signature 70 87 5.4E-43 T 09-03-2017 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 TK78_RS24440 a454e7e63d063c5497696c1f892743bf 137 PRINTS PR01243 Nucleoside diphosphate kinase signature 91 107 5.4E-43 T 09-03-2017 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 TK78_RS24440 a454e7e63d063c5497696c1f892743bf 137 PRINTS PR01243 Nucleoside diphosphate kinase signature 114 133 5.4E-43 T 09-03-2017 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 TK78_RS24440 a454e7e63d063c5497696c1f892743bf 137 ProSitePatterns PS00469 Nucleoside diphosphate kinases active site. 114 122 - T 09-03-2017 IPR023005 Nucleoside diphosphate kinase, active site KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 TK78_RS13960 cbe7016cd162cf1b60e88efb5746e648 349 Gene3D G3DSA:3.90.180.10 1 177 9.2E-57 T 09-03-2017 IPR011032 GroES-like TK78_RS13960 cbe7016cd162cf1b60e88efb5746e648 349 SUPERFAMILY SSF51735 147 314 9.69E-38 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS13960 cbe7016cd162cf1b60e88efb5746e648 349 Gene3D G3DSA:3.40.50.720 178 284 4.8E-32 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS13960 cbe7016cd162cf1b60e88efb5746e648 349 SMART SM00829 8 347 1.2E-6 T 09-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 TK78_RS13960 cbe7016cd162cf1b60e88efb5746e648 349 Pfam PF00107 Zinc-binding dehydrogenase 185 305 8.2E-21 T 09-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 TK78_RS13960 cbe7016cd162cf1b60e88efb5746e648 349 SUPERFAMILY SSF50129 302 349 9.89E-5 T 09-03-2017 IPR011032 GroES-like TK78_RS13960 cbe7016cd162cf1b60e88efb5746e648 349 SUPERFAMILY SSF50129 1 181 1.52E-51 T 09-03-2017 IPR011032 GroES-like TK78_RS13960 cbe7016cd162cf1b60e88efb5746e648 349 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 24 142 2.3E-26 T 09-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 TK78_RS13960 cbe7016cd162cf1b60e88efb5746e648 349 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 57 71 - T 09-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 TK78_RS32530 78d92a2fef660c6919c7f2c6c26def21 452 SMART SM01091 352 432 6.6E-20 T 09-03-2017 IPR005170 Transporter-associated domain TK78_RS32530 78d92a2fef660c6919c7f2c6c26def21 452 Gene3D G3DSA:3.10.580.10 205 332 3.1E-17 T 09-03-2017 TK78_RS32530 78d92a2fef660c6919c7f2c6c26def21 452 SMART SM00116 290 338 1.7 T 09-03-2017 IPR000644 CBS domain TK78_RS32530 78d92a2fef660c6919c7f2c6c26def21 452 SMART SM00116 227 276 1.7 T 09-03-2017 IPR000644 CBS domain TK78_RS32530 78d92a2fef660c6919c7f2c6c26def21 452 SUPERFAMILY SSF54631 206 341 2.27E-27 T 09-03-2017 TK78_RS32530 78d92a2fef660c6919c7f2c6c26def21 452 Pfam PF01595 Domain of unknown function DUF21 10 200 7.4E-35 T 09-03-2017 IPR002550 Domain of unknown function DUF21 TK78_RS32530 78d92a2fef660c6919c7f2c6c26def21 452 Gene3D G3DSA:3.30.465.10 333 430 5.6E-23 T 09-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 TK78_RS32530 78d92a2fef660c6919c7f2c6c26def21 452 Pfam PF03471 Transporter associated domain 355 431 8.8E-20 T 09-03-2017 IPR005170 Transporter-associated domain TK78_RS32530 78d92a2fef660c6919c7f2c6c26def21 452 SUPERFAMILY SSF56176 354 438 1.06E-19 T 09-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 TK78_RS32530 78d92a2fef660c6919c7f2c6c26def21 452 Pfam PF00571 CBS domain 220 274 2.1E-5 T 09-03-2017 IPR000644 CBS domain TK78_RS32530 78d92a2fef660c6919c7f2c6c26def21 452 Pfam PF00571 CBS domain 289 338 2.6E-4 T 09-03-2017 IPR000644 CBS domain TK78_RS27290 38d71850a3c1904011ac22d8d24dd6da 950 SUPERFAMILY SSF52540 123 227 3.71E-7 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27290 38d71850a3c1904011ac22d8d24dd6da 950 SUPERFAMILY SSF52540 7 84 3.71E-7 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27290 38d71850a3c1904011ac22d8d24dd6da 950 Gene3D G3DSA:3.40.50.300 11 72 3.6E-5 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27290 38d71850a3c1904011ac22d8d24dd6da 950 Gene3D G3DSA:3.40.50.300 115 173 3.6E-5 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27290 38d71850a3c1904011ac22d8d24dd6da 950 Pfam PF00196 Bacterial regulatory proteins, luxR family 893 947 4.4E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS27290 38d71850a3c1904011ac22d8d24dd6da 950 SMART SM00421 891 948 2.1E-21 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS27290 38d71850a3c1904011ac22d8d24dd6da 950 Gene3D G3DSA:1.25.40.10 476 820 4.5E-7 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS27290 38d71850a3c1904011ac22d8d24dd6da 950 Pfam PF13191 AAA ATPase domain 6 161 2.7E-11 T 09-03-2017 TK78_RS27290 38d71850a3c1904011ac22d8d24dd6da 950 SUPERFAMILY SSF46894 884 947 1.7E-16 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS27290 38d71850a3c1904011ac22d8d24dd6da 950 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 894 908 9.8E-8 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS27290 38d71850a3c1904011ac22d8d24dd6da 950 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 924 936 9.8E-8 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS27290 38d71850a3c1904011ac22d8d24dd6da 950 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 908 924 9.8E-8 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS27290 38d71850a3c1904011ac22d8d24dd6da 950 Gene3D G3DSA:1.10.10.10 887 947 2.2E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS17620 838d2334cf9474d8969325c878b9cd18 566 Pfam PF00171 Aldehyde dehydrogenase family 96 479 8.1E-30 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS17620 838d2334cf9474d8969325c878b9cd18 566 SUPERFAMILY SSF53720 75 542 2.49E-53 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS17620 838d2334cf9474d8969325c878b9cd18 566 TIGRFAM TIGR02288 PaaN_2: phenylacetic acid degradation protein paaN 8 566 9.8E-291 T 09-03-2017 IPR011975 Phenylacetic acid degradation protein PaaN2 TK78_RS17620 838d2334cf9474d8969325c878b9cd18 566 Gene3D G3DSA:3.40.309.10 320 527 2.7E-27 T 09-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 TK78_RS17620 838d2334cf9474d8969325c878b9cd18 566 Gene3D G3DSA:3.40.605.10 96 311 3.4E-25 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS17735 47bbf84fd375b1616f93cbd7767818c0 299 PRINTS PR00725 D-Ala-D-Ala carboxypeptidase 1 (S11) family signature 126 143 1.9E-12 T 09-03-2017 IPR018044 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A GO:0006508|GO:0009002 TK78_RS17735 47bbf84fd375b1616f93cbd7767818c0 299 PRINTS PR00725 D-Ala-D-Ala carboxypeptidase 1 (S11) family signature 159 172 1.9E-12 T 09-03-2017 IPR018044 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A GO:0006508|GO:0009002 TK78_RS17735 47bbf84fd375b1616f93cbd7767818c0 299 PRINTS PR00725 D-Ala-D-Ala carboxypeptidase 1 (S11) family signature 72 83 1.9E-12 T 09-03-2017 IPR018044 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A GO:0006508|GO:0009002 TK78_RS17735 47bbf84fd375b1616f93cbd7767818c0 299 Pfam PF00768 D-alanyl-D-alanine carboxypeptidase 40 278 4.7E-43 T 09-03-2017 IPR001967 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, N-terminal GO:0006508|GO:0009002 TK78_RS17735 47bbf84fd375b1616f93cbd7767818c0 299 Gene3D G3DSA:3.40.710.10 41 298 5.4E-80 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS17735 47bbf84fd375b1616f93cbd7767818c0 299 SUPERFAMILY SSF56601 44 297 1.13E-57 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS04560 27030f3557cb0e0ae751557844521caa 215 SUPERFAMILY SSF48498 84 186 1.7E-15 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS04560 27030f3557cb0e0ae751557844521caa 215 Pfam PF13305 WHG domain 87 178 3.6E-10 T 09-03-2017 IPR025996 WHG domain TK78_RS04560 27030f3557cb0e0ae751557844521caa 215 Pfam PF00440 Bacterial regulatory proteins, tetR family 11 57 4.8E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS04560 27030f3557cb0e0ae751557844521caa 215 Gene3D G3DSA:1.10.357.10 7 191 3.0E-38 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS04560 27030f3557cb0e0ae751557844521caa 215 SUPERFAMILY SSF46689 6 71 2.99E-13 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS07265 5a8fa339bee5781552d52657cec88d03 515 ProSitePatterns PS00715 Sigma-70 factors family signature 1. 306 319 - T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS07265 5a8fa339bee5781552d52657cec88d03 515 ProSitePatterns PS00716 Sigma-70 factors family signature 2. 475 501 - T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS07265 5a8fa339bee5781552d52657cec88d03 515 Hamap MF_00963 RNA polymerase sigma factor RpoD [rpoD]. 116 515 31.648 T 09-03-2017 IPR028630 RNA polymerase sigma factor RpoD GO:0006352|GO:0016987 TK78_RS07265 5a8fa339bee5781552d52657cec88d03 515 SUPERFAMILY SSF88659 413 514 2.62E-27 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS07265 5a8fa339bee5781552d52657cec88d03 515 Gene3D G3DSA:1.10.10.10 444 515 2.0E-31 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS07265 5a8fa339bee5781552d52657cec88d03 515 SUPERFAMILY SSF88946 214 352 6.15E-54 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS07265 5a8fa339bee5781552d52657cec88d03 515 TIGRFAM TIGR02393 RpoD_Cterm: RNA polymerase sigma factor RpoD 278 514 9.1E-113 T 09-03-2017 IPR012760 RNA polymerase sigma factor RpoD, C-terminal GO:0003677|GO:0006352|GO:0006355|GO:0016987 TK78_RS07265 5a8fa339bee5781552d52657cec88d03 515 SUPERFAMILY SSF88659 355 428 3.92E-21 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS07265 5a8fa339bee5781552d52657cec88d03 515 Pfam PF04539 Sigma-70 region 3 361 437 1.1E-28 T 09-03-2017 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS07265 5a8fa339bee5781552d52657cec88d03 515 Pfam PF00140 Sigma-70 factor, region 1.2 217 250 8.1E-17 T 09-03-2017 IPR009042 RNA polymerase sigma-70 region 1.2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS07265 5a8fa339bee5781552d52657cec88d03 515 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 278 503 2.0E-36 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS07265 5a8fa339bee5781552d52657cec88d03 515 Pfam PF04545 Sigma-70, region 4 450 503 2.9E-18 T 09-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS07265 5a8fa339bee5781552d52657cec88d03 515 PRINTS PR00046 Major sigma-70 factor signature 475 490 7.0E-29 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS07265 5a8fa339bee5781552d52657cec88d03 515 PRINTS PR00046 Major sigma-70 factor signature 490 501 7.0E-29 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS07265 5a8fa339bee5781552d52657cec88d03 515 PRINTS PR00046 Major sigma-70 factor signature 454 466 7.0E-29 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS07265 5a8fa339bee5781552d52657cec88d03 515 PRINTS PR00046 Major sigma-70 factor signature 306 319 7.0E-29 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS07265 5a8fa339bee5781552d52657cec88d03 515 PRINTS PR00046 Major sigma-70 factor signature 330 338 7.0E-29 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS07265 5a8fa339bee5781552d52657cec88d03 515 Gene3D G3DSA:1.10.601.10 120 351 2.6E-69 T 09-03-2017 TK78_RS07265 5a8fa339bee5781552d52657cec88d03 515 Gene3D G3DSA:1.10.10.10 355 406 3.9E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS07265 5a8fa339bee5781552d52657cec88d03 515 Pfam PF04542 Sigma-70 region 2 282 351 3.1E-22 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS20535 5b35801f3a32ab65b1cb6cffee39acbb 252 TIGRFAM TIGR01549 HAD-SF-IA-v1: HAD hydrolase, family IA, variant 1 93 171 4.7E-9 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS20535 5b35801f3a32ab65b1cb6cffee39acbb 252 Pfam PF00702 haloacid dehalogenase-like hydrolase 23 171 5.2E-10 T 09-03-2017 TK78_RS20535 5b35801f3a32ab65b1cb6cffee39acbb 252 SUPERFAMILY SSF56784 1 210 2.66E-32 T 09-03-2017 IPR023214 HAD-like domain TK78_RS20535 5b35801f3a32ab65b1cb6cffee39acbb 252 Gene3D G3DSA:3.40.50.1000 2 208 2.6E-30 T 09-03-2017 IPR023214 HAD-like domain TK78_RS17265 75b1653a8a3f5ad69fc2ab9905762a68 235 SUPERFAMILY SSF46785 8 192 9.05E-31 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS17265 75b1653a8a3f5ad69fc2ab9905762a68 235 Gene3D G3DSA:1.10.10.10 4 108 2.7E-29 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS17265 75b1653a8a3f5ad69fc2ab9905762a68 235 Pfam PF03551 Transcriptional regulator PadR-like family 12 60 4.6E-12 T 09-03-2017 IPR005149 Transcription regulator PadR, N-terminal TK78_RS21055 49cd6174da217f590f06fd6db36c34db 266 Pfam PF00005 ABC transporter 39 182 1.1E-29 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS21055 49cd6174da217f590f06fd6db36c34db 266 ProSitePatterns PS00211 ABC transporters family signature. 155 169 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS21055 49cd6174da217f590f06fd6db36c34db 266 Gene3D G3DSA:3.40.50.300 13 244 6.5E-67 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS21055 49cd6174da217f590f06fd6db36c34db 266 SUPERFAMILY SSF52540 19 242 7.61E-62 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS21055 49cd6174da217f590f06fd6db36c34db 266 TIGRFAM TIGR01166 cbiO: cobalt ABC transporter, ATP-binding protein 30 211 6.1E-64 T 09-03-2017 IPR005876 Cobalt transport protein ATP-binding subunit GO:0006824 TK78_RS21055 49cd6174da217f590f06fd6db36c34db 266 SMART SM00382 46 242 1.3E-11 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS29520 5d299ed9e830dfd16007699cbc4c3859 181 SMART SM00530 12 67 2.7E-12 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS29520 5d299ed9e830dfd16007699cbc4c3859 181 Gene3D G3DSA:1.10.260.40 9 86 2.5E-15 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS29520 5d299ed9e830dfd16007699cbc4c3859 181 Pfam PF13560 Helix-turn-helix domain 9 64 1.2E-11 T 09-03-2017 TK78_RS29520 5d299ed9e830dfd16007699cbc4c3859 181 SUPERFAMILY SSF47413 5 68 5.18E-13 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS29520 5d299ed9e830dfd16007699cbc4c3859 181 Pfam PF07883 Cupin domain 108 161 1.2E-8 T 09-03-2017 IPR013096 Cupin 2, conserved barrel TK78_RS29520 5d299ed9e830dfd16007699cbc4c3859 181 SUPERFAMILY SSF51182 78 167 2.92E-15 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS29520 5d299ed9e830dfd16007699cbc4c3859 181 Gene3D G3DSA:2.60.120.10 87 168 2.3E-14 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS08660 52c999cea4e4808dd941d33aabaaa620 558 Gene3D G3DSA:3.40.190.10 155 293 6.8E-27 T 09-03-2017 TK78_RS08660 52c999cea4e4808dd941d33aabaaa620 558 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 90 451 9.9E-70 T 09-03-2017 IPR000914 Solute-binding protein family 5 domain TK78_RS08660 52c999cea4e4808dd941d33aabaaa620 558 Gene3D G3DSA:3.10.105.10 294 512 2.0E-48 T 09-03-2017 TK78_RS08660 52c999cea4e4808dd941d33aabaaa620 558 SUPERFAMILY SSF53850 39 536 1.55E-94 T 09-03-2017 TK78_RS08660 52c999cea4e4808dd941d33aabaaa620 558 Gene3D G3DSA:3.90.76.10 85 138 4.3E-14 T 09-03-2017 TK78_RS08660 52c999cea4e4808dd941d33aabaaa620 558 PIRSF PIRSF002741 1 515 4.3E-69 T 09-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 TK78_RS20730 e51594d2e5f620b08d562fc594ead900 907 Gene3D G3DSA:3.40.50.150 477 545 3.4E-9 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS20730 e51594d2e5f620b08d562fc594ead900 907 Gene3D G3DSA:3.40.50.150 88 152 3.4E-9 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS20730 e51594d2e5f620b08d562fc594ead900 907 Pfam PF06634 Protein of unknown function (DUF1156) 16 67 1.6E-8 T 09-03-2017 IPR009537 Domain of unknown function DUF1156 TK78_RS20730 e51594d2e5f620b08d562fc594ead900 907 SUPERFAMILY SSF53335 81 150 7.11E-11 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS20730 e51594d2e5f620b08d562fc594ead900 907 SUPERFAMILY SSF53335 475 520 7.11E-11 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS19975 a3ce944ca009c397fac286822b16afae 362 Gene3D G3DSA:3.40.50.720 3 214 3.6E-29 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS19975 a3ce944ca009c397fac286822b16afae 362 Pfam PF01370 NAD dependent epimerase/dehydratase family 5 236 3.2E-22 T 09-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 TK78_RS19975 a3ce944ca009c397fac286822b16afae 362 SUPERFAMILY SSF51735 2 316 5.2E-38 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS00515 3f13a8628d1802236b2da1d8dacbee96 208 Pfam PF13649 Methyltransferase domain 51 144 1.1E-16 T 09-03-2017 TK78_RS00515 3f13a8628d1802236b2da1d8dacbee96 208 SUPERFAMILY SSF53335 7 192 1.81E-32 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS00515 3f13a8628d1802236b2da1d8dacbee96 208 Gene3D G3DSA:3.40.50.150 18 186 5.4E-34 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS07805 d7912849283720db5bc549176dbd1312 299 Pfam PF09142 tRNA Pseudouridine synthase II, C terminal 243 299 9.6E-17 T 09-03-2017 IPR015225 tRNA pseudouridine synthase II, TruB, subfamily 2, C-terminal GO:0001522|GO:0003723|GO:0009451|GO:0009982 TK78_RS07805 d7912849283720db5bc549176dbd1312 299 SUPERFAMILY SSF55120 8 231 1.42E-67 T 09-03-2017 IPR020103 Pseudouridine synthase, catalytic domain GO:0001522|GO:0003723|GO:0009451|GO:0009982 TK78_RS07805 d7912849283720db5bc549176dbd1312 299 Pfam PF01509 TruB family pseudouridylate synthase (N terminal domain) 31 187 1.2E-45 T 09-03-2017 IPR002501 Pseudouridine synthase II, N-terminal GO:0006396 TK78_RS07805 d7912849283720db5bc549176dbd1312 299 Hamap MF_01080 tRNA pseudouridine synthase B [truB]. 8 298 16.544 T 09-03-2017 IPR014780 tRNA pseudouridine synthase II, TruB GO:0001522|GO:0003723|GO:0009451|GO:0009982 TK78_RS07805 d7912849283720db5bc549176dbd1312 299 Pfam PF16198 tRNA pseudouridylate synthase B C-terminal domain 188 229 1.1E-10 T 09-03-2017 IPR032819 tRNA pseudouridylate synthase B, C-terminal Reactome: R-HSA-171319|Reactome: R-HSA-6790901 TK78_RS07805 d7912849283720db5bc549176dbd1312 299 TIGRFAM TIGR00431 TruB: tRNA pseudouridine(55) synthase 9 224 7.0E-63 T 09-03-2017 IPR014780 tRNA pseudouridine synthase II, TruB GO:0001522|GO:0003723|GO:0009451|GO:0009982 TK78_RS07805 d7912849283720db5bc549176dbd1312 299 SUPERFAMILY SSF88697 243 298 1.04E-9 T 09-03-2017 IPR015947 PUA-like domain TK78_RS09445 9af4929abe31650c0efe0fd7244d1064 566 Pfam PF01642 Methylmalonyl-CoA mutase 29 558 4.4E-212 T 09-03-2017 IPR006099 Methylmalonyl-CoA mutase, alpha/beta chain, catalytic GO:0008152|GO:0016866|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 TK78_RS09445 9af4929abe31650c0efe0fd7244d1064 566 TIGRFAM TIGR00641 acid_CoA_mut_N: methylmalonyl-CoA mutase N-terminal domain 27 563 9.0E-199 T 09-03-2017 IPR006098 Methylmalonyl-CoA mutase, alpha chain, catalytic GO:0004494|GO:0008152|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 TK78_RS09445 9af4929abe31650c0efe0fd7244d1064 566 Gene3D G3DSA:3.20.20.240 28 560 1.6E-212 T 09-03-2017 IPR014348 Cobalamin (vitamin B12)-dependent enzyme, catalytic subdomain GO:0008152|GO:0016866|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 TK78_RS09445 9af4929abe31650c0efe0fd7244d1064 566 SUPERFAMILY SSF51703 11 560 4.97E-191 T 09-03-2017 IPR016176 Cobalamin (vitamin B12)-dependent enzyme, catalytic GO:0003824|GO:0008152|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 TK78_RS08520 72e7265ba26a419d87ce70c735ba30ca 357 SUPERFAMILY SSF81345 25 352 4.71E-79 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS08520 72e7265ba26a419d87ce70c735ba30ca 357 Pfam PF01032 FecCD transport family 41 351 4.4E-86 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS08520 72e7265ba26a419d87ce70c735ba30ca 357 Gene3D G3DSA:1.10.3470.10 22 353 1.4E-101 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS34290 f0010e905c4fcdca38bcb07e1b46fd56 315 TIGRFAM TIGR03168 1-PFK: hexose kinase, 1-phosphofructokinase family 2 294 6.1E-98 T 09-03-2017 IPR017583 Tagatose/fructose phosphokinase GO:0005975|GO:0016773 TK78_RS34290 f0010e905c4fcdca38bcb07e1b46fd56 315 PIRSF PIRSF000535 1 294 1.7E-75 T 09-03-2017 IPR017583 Tagatose/fructose phosphokinase GO:0005975|GO:0016773 TK78_RS34290 f0010e905c4fcdca38bcb07e1b46fd56 315 Gene3D G3DSA:3.40.1190.20 32 294 2.0E-72 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS34290 f0010e905c4fcdca38bcb07e1b46fd56 315 Pfam PF00294 pfkB family carbohydrate kinase 24 289 4.0E-38 T 09-03-2017 IPR011611 Carbohydrate kinase PfkB TK78_RS34290 f0010e905c4fcdca38bcb07e1b46fd56 315 SUPERFAMILY SSF53613 1 292 2.49E-61 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS34290 f0010e905c4fcdca38bcb07e1b46fd56 315 TIGRFAM TIGR03828 pfkB: 1-phosphofructokinase 2 294 3.6E-97 T 09-03-2017 IPR022463 Fructose 1-phosphate kinase GO:0008662 KEGG: 00051+2.7.1.56 TK78_RS02950 dff6e0740e95f2f52378d2aefbf82aad 1166 SMART SM00089 1082 1166 1.0E-16 T 09-03-2017 IPR022409 PKD/Chitinase domain TK78_RS02950 dff6e0740e95f2f52378d2aefbf82aad 1166 SMART SM00089 741 826 6.8E-15 T 09-03-2017 IPR022409 PKD/Chitinase domain TK78_RS02950 dff6e0740e95f2f52378d2aefbf82aad 1166 Pfam PF07995 Glucose / Sorbosone dehydrogenase 294 553 4.5E-33 T 09-03-2017 IPR012938 Glucose/Sorbosone dehydrogenase GO:0005975|GO:0016901|GO:0048038 TK78_RS02950 dff6e0740e95f2f52378d2aefbf82aad 1166 Pfam PF00801 PKD domain 756 814 9.3E-10 T 09-03-2017 IPR000601 PKD domain TK78_RS02950 dff6e0740e95f2f52378d2aefbf82aad 1166 Pfam PF00801 PKD domain 1094 1157 1.6E-11 T 09-03-2017 IPR000601 PKD domain TK78_RS02950 dff6e0740e95f2f52378d2aefbf82aad 1166 SUPERFAMILY SSF49299 738 825 3.53E-17 T 09-03-2017 IPR000601 PKD domain TK78_RS02950 dff6e0740e95f2f52378d2aefbf82aad 1166 Gene3D G3DSA:2.60.40.670 741 826 2.7E-17 T 09-03-2017 IPR000601 PKD domain TK78_RS02950 dff6e0740e95f2f52378d2aefbf82aad 1166 Gene3D G3DSA:2.120.10.30 277 740 5.3E-94 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS02950 dff6e0740e95f2f52378d2aefbf82aad 1166 SUPERFAMILY SSF49299 1084 1165 2.22E-15 T 09-03-2017 IPR000601 PKD domain TK78_RS02950 dff6e0740e95f2f52378d2aefbf82aad 1166 Pfam PF06283 Trehalose utilisation 50 267 1.3E-72 T 09-03-2017 IPR029010 ThuA-like domain TK78_RS02950 dff6e0740e95f2f52378d2aefbf82aad 1166 SMART SM00606 935 1072 4.3E-14 T 09-03-2017 IPR006584 Cellulose binding, type IV GO:0030246 TK78_RS02950 dff6e0740e95f2f52378d2aefbf82aad 1166 Gene3D G3DSA:2.60.120.260 941 1072 2.1E-27 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS02950 dff6e0740e95f2f52378d2aefbf82aad 1166 Gene3D G3DSA:3.40.50.880 46 276 7.6E-38 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS02950 dff6e0740e95f2f52378d2aefbf82aad 1166 Pfam PF03422 Carbohydrate binding module (family 6) 950 1071 1.9E-18 T 09-03-2017 IPR005084 Carbohydrate binding module family 6 GO:0030246 TK78_RS02950 dff6e0740e95f2f52378d2aefbf82aad 1166 Gene3D G3DSA:2.60.40.670 1085 1165 2.5E-17 T 09-03-2017 IPR000601 PKD domain TK78_RS02950 dff6e0740e95f2f52378d2aefbf82aad 1166 SUPERFAMILY SSF52317 50 275 1.17E-41 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS02950 dff6e0740e95f2f52378d2aefbf82aad 1166 SUPERFAMILY SSF49785 939 1070 2.04E-14 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS02950 dff6e0740e95f2f52378d2aefbf82aad 1166 SUPERFAMILY SSF50952 280 556 1.57E-22 T 09-03-2017 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 TK78_RS33675 296263f777bea9645241408eda4d3d05 350 SUPERFAMILY SSF53807 55 345 1.06E-51 T 09-03-2017 TK78_RS33675 296263f777bea9645241408eda4d3d05 350 Pfam PF01497 Periplasmic binding protein 112 318 2.5E-28 T 09-03-2017 IPR002491 ABC transporter periplasmic binding domain GO:0005488 TK78_RS33675 296263f777bea9645241408eda4d3d05 350 Gene3D G3DSA:3.40.50.1980 197 345 3.7E-18 T 09-03-2017 TK78_RS33675 296263f777bea9645241408eda4d3d05 350 Gene3D G3DSA:3.40.50.1980 53 196 2.3E-27 T 09-03-2017 TK78_RS04745 adde07ed95a17fe9b162c96d0b69c647 214 Gene3D G3DSA:1.10.3720.10 8 210 1.4E-37 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS04745 adde07ed95a17fe9b162c96d0b69c647 214 SUPERFAMILY SSF161098 11 199 3.4E-36 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS04745 adde07ed95a17fe9b162c96d0b69c647 214 TIGRFAM TIGR01726 HEQRo_perm_3TM: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family 10 105 4.0E-17 T 09-03-2017 IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain GO:0005215|GO:0006810|GO:0016021 TK78_RS04745 adde07ed95a17fe9b162c96d0b69c647 214 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 30 206 3.9E-14 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS21110 63fd119db63f82b004244651f0b69346 169 Gene3D G3DSA:3.90.960.10 18 166 9.7E-45 T 09-03-2017 IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain GO:0002161 KEGG: 00970+6.1.1.15 TK78_RS21110 63fd119db63f82b004244651f0b69346 169 Pfam PF04073 Aminoacyl-tRNA editing domain 38 154 9.4E-28 T 09-03-2017 IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain GO:0002161 KEGG: 00970+6.1.1.15 TK78_RS21110 63fd119db63f82b004244651f0b69346 169 SUPERFAMILY SSF55826 20 165 5.49E-36 T 09-03-2017 IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain GO:0002161 KEGG: 00970+6.1.1.15 TK78_RS23850 f6e7f66090c54c7e8e4594ce3057eced 189 Pfam PF07336 Putative stress-induced transcription regulator 14 134 3.1E-16 T 09-03-2017 IPR010852 Putative stress-induced transcription regulator TK78_RS23850 f6e7f66090c54c7e8e4594ce3057eced 189 SUPERFAMILY SSF160904 7 179 4.05E-38 T 09-03-2017 TK78_RS23850 f6e7f66090c54c7e8e4594ce3057eced 189 Pfam PF11706 CGNR zinc finger 140 180 8.1E-15 T 09-03-2017 IPR021005 Zinc finger, CGNR TK78_RS23850 f6e7f66090c54c7e8e4594ce3057eced 189 Gene3D G3DSA:1.10.3300.10 7 180 8.9E-38 T 09-03-2017 IPR023286 ABATE domain TK78_RS12925 dab20128fad284ab5b2ee516315eee10 403 Pfam PF08281 Sigma-70, region 4 109 157 4.0E-8 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12925 dab20128fad284ab5b2ee516315eee10 403 SUPERFAMILY SSF88946 2 74 1.77E-10 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12925 dab20128fad284ab5b2ee516315eee10 403 Gene3D G3DSA:1.10.10.10 100 160 2.4E-12 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS12925 dab20128fad284ab5b2ee516315eee10 403 SUPERFAMILY SSF88659 99 159 2.8E-9 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12925 dab20128fad284ab5b2ee516315eee10 403 Gene3D G3DSA:1.10.1740.10 2 67 1.6E-8 T 09-03-2017 TK78_RS12925 dab20128fad284ab5b2ee516315eee10 403 Pfam PF04542 Sigma-70 region 2 3 67 9.9E-9 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS03950 118aa0e0113d40f6ca327d44a913bb02 350 Pfam PF02653 Branched-chain amino acid transport system / permease component 72 338 1.3E-42 T 09-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 TK78_RS12650 1bcc400ef6bfe9e213d15d8971755187 101 SUPERFAMILY SSF48600 28 84 1.68E-9 T 09-03-2017 IPR020822 Chorismate mutase, type II GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 TK78_RS12650 1bcc400ef6bfe9e213d15d8971755187 101 Pfam PF01817 Chorismate mutase type II 30 80 6.5E-7 T 09-03-2017 IPR020822 Chorismate mutase, type II GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 TK78_RS12650 1bcc400ef6bfe9e213d15d8971755187 101 Gene3D G3DSA:1.20.59.10 19 78 2.2E-8 T 09-03-2017 IPR002701 Chorismate mutase GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 TK78_RS12650 1bcc400ef6bfe9e213d15d8971755187 101 SMART SM00830 30 93 5.9E-4 T 09-03-2017 IPR002701 Chorismate mutase GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 TK78_RS12650 1bcc400ef6bfe9e213d15d8971755187 101 TIGRFAM TIGR01808 CM_M_hiGC-arch: chorismate mutase 29 99 7.5E-15 T 09-03-2017 IPR010958 Chorismate mutase, high GC Gram-positive bacteria/archaeal TK78_RS29865 23c317780141623ea1bccc9df0851fb2 223 Gene3D G3DSA:3.40.1130.10 8 207 2.7E-35 T 09-03-2017 TK78_RS29865 23c317780141623ea1bccc9df0851fb2 223 SMART SM00563 35 154 7.3E-33 T 09-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 TK78_RS29865 23c317780141623ea1bccc9df0851fb2 223 Pfam PF01553 Acyltransferase 21 151 3.0E-21 T 09-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 TK78_RS29865 23c317780141623ea1bccc9df0851fb2 223 SUPERFAMILY SSF69593 5 221 3.79E-48 T 09-03-2017 TK78_RS15325 340156453f0bf38a58068add0e24202d 826 Pfam PF00270 DEAD/DEAH box helicase 102 277 4.3E-25 T 09-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 TK78_RS15325 340156453f0bf38a58068add0e24202d 826 SMART SM00490 365 446 1.0E-17 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS15325 340156453f0bf38a58068add0e24202d 826 SUPERFAMILY SSF52540 109 279 6.47E-41 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15325 340156453f0bf38a58068add0e24202d 826 SUPERFAMILY SSF52540 310 456 6.47E-41 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15325 340156453f0bf38a58068add0e24202d 826 Pfam PF00271 Helicase conserved C-terminal domain 338 446 4.2E-11 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS15325 340156453f0bf38a58068add0e24202d 826 TIGRFAM TIGR03817 DECH_helic: helicase/secretion neighborhood putative DEAH-box helicase 64 813 0.0 T 09-03-2017 IPR022307 DEAD/DEAH-box helicase, putative, actinobacteria TK78_RS15325 340156453f0bf38a58068add0e24202d 826 SMART SM00487 96 305 1.3E-29 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS15325 340156453f0bf38a58068add0e24202d 826 Pfam PF09369 Domain of unknown function (DUF1998) 707 786 1.7E-19 T 09-03-2017 IPR018973 DEAD/DEAH-box helicase, putative TK78_RS15325 340156453f0bf38a58068add0e24202d 826 Gene3D G3DSA:3.40.50.300 332 489 7.5E-21 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15325 340156453f0bf38a58068add0e24202d 826 Gene3D G3DSA:3.40.50.300 84 278 4.7E-36 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33000 e7ff7b5aab1856679fb4a89563fe24a7 622 Gene3D G3DSA:2.60.40.10 159 243 6.3E-22 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS33000 e7ff7b5aab1856679fb4a89563fe24a7 622 SMART SM00060 160 234 3.6E-10 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS33000 e7ff7b5aab1856679fb4a89563fe24a7 622 ProSitePatterns PS01095 Chitinases family 18 active site. 389 397 - T 09-03-2017 IPR001579 Glycoside hydrolase, chitinase active site GO:0004553|GO:0005975 KEGG: 00520+3.2.1.14|MetaCyc: PWY-6902 TK78_RS33000 e7ff7b5aab1856679fb4a89563fe24a7 622 Pfam PF00041 Fibronectin type III domain 161 236 1.3E-7 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS33000 e7ff7b5aab1856679fb4a89563fe24a7 622 SUPERFAMILY SSF49265 158 244 2.62E-16 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS33000 e7ff7b5aab1856679fb4a89563fe24a7 622 SUPERFAMILY SSF54556 520 578 4.97E-8 T 09-03-2017 IPR029070 Chitinase insertion domain TK78_RS33000 e7ff7b5aab1856679fb4a89563fe24a7 622 SMART SM00636 259 607 6.4E-105 T 09-03-2017 IPR011583 Chitinase II GO:0004568|GO:0006032 TK78_RS33000 e7ff7b5aab1856679fb4a89563fe24a7 622 Pfam PF00704 Glycosyl hydrolases family 18 262 607 7.7E-70 T 09-03-2017 IPR001223 Glycoside hydrolase family 18, catalytic domain GO:0004553|GO:0005975 TK78_RS33000 e7ff7b5aab1856679fb4a89563fe24a7 622 Gene3D G3DSA:3.10.50.10 522 579 1.9E-18 T 09-03-2017 IPR029070 Chitinase insertion domain TK78_RS33000 e7ff7b5aab1856679fb4a89563fe24a7 622 SMART SM00637 51 148 1.4E-43 T 09-03-2017 IPR001919 Carbohydrate-binding type-2 domain GO:0004553|GO:0005975|GO:0030246 TK78_RS33000 e7ff7b5aab1856679fb4a89563fe24a7 622 SUPERFAMILY SSF49384 48 149 3.21E-30 T 09-03-2017 IPR008965 Carbohydrate-binding domain GO:0030246 TK78_RS33000 e7ff7b5aab1856679fb4a89563fe24a7 622 SUPERFAMILY SSF51445 257 518 8.65E-77 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS33000 e7ff7b5aab1856679fb4a89563fe24a7 622 SUPERFAMILY SSF51445 577 621 8.65E-77 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS33000 e7ff7b5aab1856679fb4a89563fe24a7 622 ProSitePatterns PS00561 CBM2a (carbohydrate-binding type-2) domain signature. 116 129 - T 09-03-2017 IPR018366 Carbohydrate-binding type-2, conserved site GO:0004553|GO:0005975|GO:0030246 TK78_RS33000 e7ff7b5aab1856679fb4a89563fe24a7 622 Gene3D G3DSA:3.20.20.80 584 621 7.8E-83 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS33000 e7ff7b5aab1856679fb4a89563fe24a7 622 Gene3D G3DSA:3.20.20.80 252 521 7.8E-83 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS33000 e7ff7b5aab1856679fb4a89563fe24a7 622 Pfam PF00553 Cellulose binding domain 51 148 3.5E-31 T 09-03-2017 IPR001919 Carbohydrate-binding type-2 domain GO:0004553|GO:0005975|GO:0030246 TK78_RS33000 e7ff7b5aab1856679fb4a89563fe24a7 622 Gene3D G3DSA:2.60.40.290 50 150 4.7E-35 T 09-03-2017 IPR012291 Cellulose-binding family II/chitobiase, carbohydrate-binding domain GO:0004553|GO:0030247 TK78_RS19155 873833654ce27638bbd619a2b7534aad 522 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 41 443 1.1E-122 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS19155 873833654ce27638bbd619a2b7534aad 522 Pfam PF13193 AMP-binding enzyme C-terminal domain 428 504 8.0E-14 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS19155 873833654ce27638bbd619a2b7534aad 522 Gene3D G3DSA:3.30.300.30 414 515 1.0E-27 T 09-03-2017 TK78_RS19155 873833654ce27638bbd619a2b7534aad 522 Gene3D G3DSA:3.40.50.980 167 330 1.5E-42 T 09-03-2017 TK78_RS19155 873833654ce27638bbd619a2b7534aad 522 Gene3D G3DSA:2.30.38.10 331 409 1.3E-22 T 09-03-2017 TK78_RS19155 873833654ce27638bbd619a2b7534aad 522 ProSitePatterns PS00455 Putative AMP-binding domain signature. 157 168 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS19155 873833654ce27638bbd619a2b7534aad 522 SUPERFAMILY SSF56801 14 515 8.37E-145 T 09-03-2017 TK78_RS19155 873833654ce27638bbd619a2b7534aad 522 Gene3D G3DSA:3.40.50.980 15 166 5.7E-46 T 09-03-2017 TK78_RS19155 873833654ce27638bbd619a2b7534aad 522 Pfam PF00501 AMP-binding enzyme 20 420 3.9E-95 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS06690 494a81d6b56ce44762201ada3f3ff973 209 SUPERFAMILY SSF48498 77 183 2.37E-8 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS06690 494a81d6b56ce44762201ada3f3ff973 209 Pfam PF13977 Bacterial transcriptional repressor 78 183 4.5E-8 T 09-03-2017 TK78_RS06690 494a81d6b56ce44762201ada3f3ff973 209 Pfam PF00440 Bacterial regulatory proteins, tetR family 8 53 1.9E-14 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS06690 494a81d6b56ce44762201ada3f3ff973 209 Gene3D G3DSA:1.10.357.10 3 172 3.2E-25 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS06690 494a81d6b56ce44762201ada3f3ff973 209 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 8 21 2.7E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS06690 494a81d6b56ce44762201ada3f3ff973 209 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 29 52 2.7E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS06690 494a81d6b56ce44762201ada3f3ff973 209 SUPERFAMILY SSF46689 3 75 5.64E-16 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS24570 183a1b8d12dd54aacd6c5794b6574500 427 Pfam PF00171 Aldehyde dehydrogenase family 13 291 1.8E-20 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS24570 183a1b8d12dd54aacd6c5794b6574500 427 PIRSF PIRSF000151 7 427 1.3E-174 T 09-03-2017 IPR012134 Glutamate-5-semialdehyde dehydrogenase GO:0004350|GO:0006561|GO:0050661|GO:0055114 KEGG: 00330+1.2.1.41|KEGG: 00332+1.2.1.41|MetaCyc: PWY-3341|MetaCyc: PWY-6922 TK78_RS24570 183a1b8d12dd54aacd6c5794b6574500 427 Hamap MF_00412 Gamma-glutamyl phosphate reductase [proA]. 12 427 42.555 T 09-03-2017 IPR000965 GPR domain GO:0004350|GO:0006561|GO:0055114 KEGG: 00330+1.2.1.41|KEGG: 00332+1.2.1.41|MetaCyc: PWY-3341|MetaCyc: PWY-6922|Reactome: R-HSA-70614 TK78_RS24570 183a1b8d12dd54aacd6c5794b6574500 427 SUPERFAMILY SSF53720 11 427 1.24E-117 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS24570 183a1b8d12dd54aacd6c5794b6574500 427 Gene3D G3DSA:3.40.605.10 11 231 1.1E-104 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS24570 183a1b8d12dd54aacd6c5794b6574500 427 Gene3D G3DSA:3.40.605.10 386 427 1.1E-104 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS24570 183a1b8d12dd54aacd6c5794b6574500 427 Gene3D G3DSA:3.40.309.10 234 385 1.2E-41 T 09-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 TK78_RS24570 183a1b8d12dd54aacd6c5794b6574500 427 ProSitePatterns PS01223 Gamma-glutamyl phosphate reductase signature. 334 355 - T 09-03-2017 IPR020593 Gamma-glutamyl phosphate reductase GPR, conserved site GO:0004350|GO:0006561|GO:0055114 KEGG: 00330+1.2.1.41|KEGG: 00332+1.2.1.41|MetaCyc: PWY-3341|MetaCyc: PWY-6922|Reactome: R-HSA-70614 TK78_RS24570 183a1b8d12dd54aacd6c5794b6574500 427 TIGRFAM TIGR00407 proA: glutamate-5-semialdehyde dehydrogenase 20 417 9.9E-156 T 09-03-2017 IPR000965 GPR domain GO:0004350|GO:0006561|GO:0055114 KEGG: 00330+1.2.1.41|KEGG: 00332+1.2.1.41|MetaCyc: PWY-3341|MetaCyc: PWY-6922|Reactome: R-HSA-70614 TK78_RS20320 babc7545a53b6eec30509eed1eb17657 168 Gene3D G3DSA:1.10.10.10 44 151 9.5E-27 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS20320 babc7545a53b6eec30509eed1eb17657 168 SMART SM00347 38 137 2.2E-12 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS20320 babc7545a53b6eec30509eed1eb17657 168 SUPERFAMILY SSF46785 42 151 4.28E-24 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS20320 babc7545a53b6eec30509eed1eb17657 168 Pfam PF01047 MarR family 47 102 1.0E-8 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS34035 72902fc3d50b0c1fb57fe60487baa838 392 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 228 381 2.4E-31 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS34035 72902fc3d50b0c1fb57fe60487baa838 392 Gene3D G3DSA:1.10.540.10 4 120 7.5E-30 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS34035 72902fc3d50b0c1fb57fe60487baa838 392 SUPERFAMILY SSF56645 3 241 4.84E-70 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS34035 72902fc3d50b0c1fb57fe60487baa838 392 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 6 119 8.5E-26 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS34035 72902fc3d50b0c1fb57fe60487baa838 392 Gene3D G3DSA:2.40.110.10 122 216 6.1E-33 T 09-03-2017 TK78_RS34035 72902fc3d50b0c1fb57fe60487baa838 392 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 123 202 1.4E-19 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS34035 72902fc3d50b0c1fb57fe60487baa838 392 Gene3D G3DSA:1.20.140.10 217 389 3.3E-35 T 09-03-2017 TK78_RS34035 72902fc3d50b0c1fb57fe60487baa838 392 SUPERFAMILY SSF47203 228 388 2.9E-26 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS30150 a285ff3b38f94d4a2e07065349f9e5b1 141 TIGRFAM TIGR00778 ahpD_dom: alkylhydroperoxidase AhpD family core domain 24 73 2.3E-18 T 09-03-2017 IPR004675 Alkylhydroperoxidase AhpD core GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 TK78_RS30150 a285ff3b38f94d4a2e07065349f9e5b1 141 Gene3D G3DSA:1.20.1290.10 3 139 1.3E-50 T 09-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 TK78_RS30150 a285ff3b38f94d4a2e07065349f9e5b1 141 Pfam PF02627 Carboxymuconolactone decarboxylase family 8 88 6.8E-22 T 09-03-2017 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 TK78_RS30150 a285ff3b38f94d4a2e07065349f9e5b1 141 SUPERFAMILY SSF69118 2 139 1.83E-43 T 09-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 TK78_RS17550 4527765b6ee406e66ea96704b57b1ee4 203 SUPERFAMILY SSF52218 1 200 5.59E-32 T 09-03-2017 IPR029039 Flavoprotein-like domain TK78_RS17550 4527765b6ee406e66ea96704b57b1ee4 203 Pfam PF02525 Flavodoxin-like fold 3 149 2.4E-29 T 09-03-2017 IPR003680 Flavodoxin-like fold TK78_RS17550 4527765b6ee406e66ea96704b57b1ee4 203 Gene3D G3DSA:3.40.50.360 1 200 1.6E-51 T 09-03-2017 IPR029039 Flavoprotein-like domain TK78_RS17550 4527765b6ee406e66ea96704b57b1ee4 203 Hamap MF_01216 FMN-dependent NADH-azoreductase [azoR]. 2 198 23.441 T 09-03-2017 IPR023048 NADH-azoreductase, FMN-dependent GO:0016661|GO:0055114 TK78_RS09620 06a1870105b41f7fc9512d51b997f509 213 SUPERFAMILY SSF46689 5 83 6.98E-19 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS09620 06a1870105b41f7fc9512d51b997f509 213 Gene3D G3DSA:1.10.10.60 5 58 6.3E-19 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS09620 06a1870105b41f7fc9512d51b997f509 213 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 38 61 1.2E-6 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS09620 06a1870105b41f7fc9512d51b997f509 213 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 17 30 1.2E-6 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS09620 06a1870105b41f7fc9512d51b997f509 213 Pfam PF00440 Bacterial regulatory proteins, tetR family 19 61 3.5E-12 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS09620 06a1870105b41f7fc9512d51b997f509 213 Gene3D G3DSA:1.10.357.10 59 169 1.4E-13 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS27675 5985c37e639234f4ca9534525c8b5e46 319 Gene3D G3DSA:2.160.20.10 21 310 9.1E-27 T 09-03-2017 IPR012334 Pectin lyase fold TK78_RS27675 5985c37e639234f4ca9534525c8b5e46 319 SUPERFAMILY SSF51126 35 304 2.24E-34 T 09-03-2017 IPR011050 Pectin lyase fold/virulence factor TK78_RS27675 5985c37e639234f4ca9534525c8b5e46 319 Pfam PF13229 Right handed beta helix region 91 238 4.8E-10 T 09-03-2017 TK78_RS27675 5985c37e639234f4ca9534525c8b5e46 319 SMART SM00710 100 121 580.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS27675 5985c37e639234f4ca9534525c8b5e46 319 SMART SM00710 122 144 1900.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS27675 5985c37e639234f4ca9534525c8b5e46 319 SMART SM00710 236 258 1800.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS27675 5985c37e639234f4ca9534525c8b5e46 319 SMART SM00710 146 174 97.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS27675 5985c37e639234f4ca9534525c8b5e46 319 SMART SM00710 207 229 5400.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS07890 17aeba9a6412c69b315c7af2264490ba 651 SUPERFAMILY SSF56645 39 295 3.01E-59 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS07890 17aeba9a6412c69b315c7af2264490ba 651 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 285 443 1.4E-28 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS07890 17aeba9a6412c69b315c7af2264490ba 651 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 67 172 9.8E-20 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS07890 17aeba9a6412c69b315c7af2264490ba 651 Gene3D G3DSA:1.20.140.10 274 447 7.0E-46 T 09-03-2017 TK78_RS07890 17aeba9a6412c69b315c7af2264490ba 651 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 177 273 1.5E-21 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS07890 17aeba9a6412c69b315c7af2264490ba 651 Gene3D G3DSA:1.10.540.10 37 175 2.5E-30 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS07890 17aeba9a6412c69b315c7af2264490ba 651 SUPERFAMILY SSF47203 285 444 1.77E-33 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS07890 17aeba9a6412c69b315c7af2264490ba 651 Gene3D G3DSA:2.40.110.10 176 273 1.7E-31 T 09-03-2017 TK78_RS17445 56470f0eb9e76d1d4c993a5677b3bc6d 182 Gene3D G3DSA:1.10.260.40 25 62 2.0E-6 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS17445 56470f0eb9e76d1d4c993a5677b3bc6d 182 SUPERFAMILY SSF47413 22 75 5.63E-7 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS01760 c8b94b920bd1d481f798ab6e5656fb89 82 SUPERFAMILY SSF46911 5 76 3.14E-26 T 09-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS01760 c8b94b920bd1d481f798ab6e5656fb89 82 ProSitePatterns PS00057 Ribosomal protein S18 signature. 26 49 - T 09-03-2017 IPR018275 Ribosomal protein S18, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS01760 c8b94b920bd1d481f798ab6e5656fb89 82 Hamap MF_00270 30S ribosomal protein S18 [rpsR]. 4 78 19.832 T 09-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS01760 c8b94b920bd1d481f798ab6e5656fb89 82 ProDom PD002239 RIBOSOMAL S18 RIBONUCLEOPROTEIN 30S RRNA-BINDING RNA-BINDING CHLOROPLAST PLASTID MITOCHONDRIAL ACETYLATION 25 75 9.0E-20 T 09-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS01760 c8b94b920bd1d481f798ab6e5656fb89 82 PRINTS PR00974 Ribosomal protein S18 family signature 33 43 2.1E-17 T 09-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS01760 c8b94b920bd1d481f798ab6e5656fb89 82 PRINTS PR00974 Ribosomal protein S18 family signature 51 65 2.1E-17 T 09-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS01760 c8b94b920bd1d481f798ab6e5656fb89 82 PRINTS PR00974 Ribosomal protein S18 family signature 43 50 2.1E-17 T 09-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS01760 c8b94b920bd1d481f798ab6e5656fb89 82 PRINTS PR00974 Ribosomal protein S18 family signature 65 75 2.1E-17 T 09-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS01760 c8b94b920bd1d481f798ab6e5656fb89 82 Gene3D G3DSA:4.10.640.10 14 76 2.3E-29 T 09-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS01760 c8b94b920bd1d481f798ab6e5656fb89 82 Pfam PF01084 Ribosomal protein S18 23 73 3.8E-24 T 09-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS01760 c8b94b920bd1d481f798ab6e5656fb89 82 TIGRFAM TIGR00165 S18: ribosomal protein bS18 20 75 5.4E-23 T 09-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS26620 6fbcfceb9e69b12cba6906b86790b6d6 890 Gene3D G3DSA:3.40.50.970 484 717 7.5E-114 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS26620 6fbcfceb9e69b12cba6906b86790b6d6 890 SUPERFAMILY SSF52518 66 477 1.29E-113 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS26620 6fbcfceb9e69b12cba6906b86790b6d6 890 SUPERFAMILY SSF52518 485 713 2.83E-91 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS26620 6fbcfceb9e69b12cba6906b86790b6d6 890 Gene3D G3DSA:3.40.50.920 719 890 4.1E-64 T 09-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 TK78_RS26620 6fbcfceb9e69b12cba6906b86790b6d6 890 PIRSF PIRSF000156 7 890 0.0 T 09-03-2017 IPR004660 2-oxo-acid dehydrogenase E1 component homodimeric type GO:0016491|GO:0055114 KEGG: 00010+1.2.4.1|KEGG: 00020+1.2.4.1|KEGG: 00620+1.2.4.1 TK78_RS26620 6fbcfceb9e69b12cba6906b86790b6d6 890 Gene3D G3DSA:3.40.50.970 66 478 4.9E-135 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS26620 6fbcfceb9e69b12cba6906b86790b6d6 890 Pfam PF00456 Transketolase, thiamine diphosphate binding domain 147 300 1.7E-10 T 09-03-2017 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 TK78_RS26620 6fbcfceb9e69b12cba6906b86790b6d6 890 SUPERFAMILY SSF52922 714 890 1.34E-48 T 09-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 TK78_RS26620 6fbcfceb9e69b12cba6906b86790b6d6 890 TIGRFAM TIGR00759 aceE: pyruvate dehydrogenase (acetyl-transferring), homodimeric type 15 890 0.0 T 09-03-2017 IPR004660 2-oxo-acid dehydrogenase E1 component homodimeric type GO:0016491|GO:0055114 KEGG: 00010+1.2.4.1|KEGG: 00020+1.2.4.1|KEGG: 00620+1.2.4.1 TK78_RS26045 52d3d871dc1a5e75e34c7371ca666e22 337 Gene3D G3DSA:3.40.50.2300 185 315 2.3E-49 T 09-03-2017 TK78_RS26045 52d3d871dc1a5e75e34c7371ca666e22 337 SMART SM00354 9 79 1.5E-19 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS26045 52d3d871dc1a5e75e34c7371ca666e22 337 Pfam PF00356 Bacterial regulatory proteins, lacI family 11 56 7.2E-16 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS26045 52d3d871dc1a5e75e34c7371ca666e22 337 Gene3D G3DSA:1.10.260.40 8 58 2.2E-20 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS26045 52d3d871dc1a5e75e34c7371ca666e22 337 Pfam PF13377 Periplasmic binding protein-like domain 180 337 7.6E-38 T 09-03-2017 TK78_RS26045 52d3d871dc1a5e75e34c7371ca666e22 337 SUPERFAMILY SSF47413 8 66 1.07E-14 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS26045 52d3d871dc1a5e75e34c7371ca666e22 337 SUPERFAMILY SSF53822 82 337 4.24E-63 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS26045 52d3d871dc1a5e75e34c7371ca666e22 337 Gene3D G3DSA:3.40.50.2300 59 184 1.7E-27 T 09-03-2017 TK78_RS13065 b22f54f67d71af1ff5452bc65beb71db 151 Gene3D G3DSA:3.100.10.10 37 150 3.5E-32 T 09-03-2017 TK78_RS13065 b22f54f67d71af1ff5452bc65beb71db 151 Hamap MF_01341 50S ribosomal protein L15 [rplO]. 9 150 18.5 T 09-03-2017 IPR030878 Ribosomal protein L15 GO:0003735|GO:0006412|GO:0015934 TK78_RS13065 b22f54f67d71af1ff5452bc65beb71db 151 SUPERFAMILY SSF52080 10 149 3.27E-40 T 09-03-2017 IPR021131 Ribosomal protein L18e/L15P TK78_RS13065 b22f54f67d71af1ff5452bc65beb71db 151 TIGRFAM TIGR01071 rplO_bact: ribosomal protein uL15 10 147 1.2E-44 T 09-03-2017 IPR005749 Ribosomal protein L15, bacterial-type GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13065 b22f54f67d71af1ff5452bc65beb71db 151 Pfam PF00828 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A 32 148 4.8E-33 T 09-03-2017 IPR021131 Ribosomal protein L18e/L15P TK78_RS13065 b22f54f67d71af1ff5452bc65beb71db 151 ProSitePatterns PS00475 Ribosomal protein L15 signature. 114 144 - T 09-03-2017 IPR001196 Ribosomal protein L15, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS27895 5c90dd1cb9c8e272ef458c7a1bf7411c 552 Pfam PF00342 Phosphoglucose isomerase 54 543 1.1E-219 T 09-03-2017 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|Reactome: R-HSA-5628897|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27895 5c90dd1cb9c8e272ef458c7a1bf7411c 552 ProSitePatterns PS00174 Phosphoglucose isomerase signature 2. 497 514 - T 09-03-2017 IPR018189 Phosphoglucose isomerase, conserved site GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|Reactome: R-HSA-5628897|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27895 5c90dd1cb9c8e272ef458c7a1bf7411c 552 Gene3D G3DSA:1.10.1390.10 502 550 5.4E-18 T 09-03-2017 IPR023096 Phosphoglucose isomerase, C-terminal GO:0004347|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|Reactome: R-HSA-5628897|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27895 5c90dd1cb9c8e272ef458c7a1bf7411c 552 PRINTS PR00662 Glucose-6-phosphate isomerase signature 342 363 7.5E-53 T 09-03-2017 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|Reactome: R-HSA-5628897|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27895 5c90dd1cb9c8e272ef458c7a1bf7411c 552 PRINTS PR00662 Glucose-6-phosphate isomerase signature 152 171 7.5E-53 T 09-03-2017 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|Reactome: R-HSA-5628897|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27895 5c90dd1cb9c8e272ef458c7a1bf7411c 552 PRINTS PR00662 Glucose-6-phosphate isomerase signature 265 283 7.5E-53 T 09-03-2017 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|Reactome: R-HSA-5628897|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27895 5c90dd1cb9c8e272ef458c7a1bf7411c 552 PRINTS PR00662 Glucose-6-phosphate isomerase signature 497 510 7.5E-53 T 09-03-2017 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|Reactome: R-HSA-5628897|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27895 5c90dd1cb9c8e272ef458c7a1bf7411c 552 PRINTS PR00662 Glucose-6-phosphate isomerase signature 465 483 7.5E-53 T 09-03-2017 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|Reactome: R-HSA-5628897|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27895 5c90dd1cb9c8e272ef458c7a1bf7411c 552 PRINTS PR00662 Glucose-6-phosphate isomerase signature 483 497 7.5E-53 T 09-03-2017 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|Reactome: R-HSA-5628897|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27895 5c90dd1cb9c8e272ef458c7a1bf7411c 552 Gene3D G3DSA:3.40.50.10490 7 104 1.1E-157 T 09-03-2017 TK78_RS27895 5c90dd1cb9c8e272ef458c7a1bf7411c 552 Gene3D G3DSA:3.40.50.10490 267 501 1.1E-157 T 09-03-2017 TK78_RS27895 5c90dd1cb9c8e272ef458c7a1bf7411c 552 Gene3D G3DSA:3.40.50.10490 149 187 1.1E-157 T 09-03-2017 TK78_RS27895 5c90dd1cb9c8e272ef458c7a1bf7411c 552 SUPERFAMILY SSF53697 9 550 2.06E-206 T 09-03-2017 TK78_RS27895 5c90dd1cb9c8e272ef458c7a1bf7411c 552 Hamap MF_00473 Glucose-6-phosphate isomerase [pgi]. 48 524 41.472 T 09-03-2017 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|Reactome: R-HSA-5628897|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS18735 fd1dd0fefe60f54b78809128494f4e1b 465 Gene3D G3DSA:3.90.226.10 239 458 4.2E-30 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS18735 fd1dd0fefe60f54b78809128494f4e1b 465 SUPERFAMILY SSF52096 129 441 6.96E-41 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS18735 fd1dd0fefe60f54b78809128494f4e1b 465 SMART SM00245 218 434 1.9E-4 T 09-03-2017 IPR005151 Tail specific protease GO:0006508|GO:0008236 Reactome: R-HSA-2187335|Reactome: R-HSA-2453902 TK78_RS18735 fd1dd0fefe60f54b78809128494f4e1b 465 Pfam PF03572 Peptidase family S41 249 431 2.3E-24 T 09-03-2017 IPR005151 Tail specific protease GO:0006508|GO:0008236 Reactome: R-HSA-2187335|Reactome: R-HSA-2453902 TK78_RS18735 fd1dd0fefe60f54b78809128494f4e1b 465 Gene3D G3DSA:3.30.750.44 131 193 1.8E-12 T 09-03-2017 TK78_RS18735 fd1dd0fefe60f54b78809128494f4e1b 465 Pfam PF14684 Tricorn protease C1 domain 131 193 3.1E-12 T 09-03-2017 IPR028204 Tricorn protease C1 domain TK78_RS03760 62037e30e884ac3cc0253601cc3a9af0 685 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 542 671 4.5E-27 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS03760 62037e30e884ac3cc0253601cc3a9af0 685 SMART SM00387 541 673 4.8E-45 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS03760 62037e30e884ac3cc0253601cc3a9af0 685 SUPERFAMILY SSF158472 379 423 6.67E-9 T 09-03-2017 TK78_RS03760 62037e30e884ac3cc0253601cc3a9af0 685 PRINTS PR00344 Bacterial sensor protein C-terminal signature 633 651 6.7E-20 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS03760 62037e30e884ac3cc0253601cc3a9af0 685 PRINTS PR00344 Bacterial sensor protein C-terminal signature 657 670 6.7E-20 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS03760 62037e30e884ac3cc0253601cc3a9af0 685 PRINTS PR00344 Bacterial sensor protein C-terminal signature 598 612 6.7E-20 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS03760 62037e30e884ac3cc0253601cc3a9af0 685 PRINTS PR00344 Bacterial sensor protein C-terminal signature 616 626 6.7E-20 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS03760 62037e30e884ac3cc0253601cc3a9af0 685 Pfam PF00672 HAMP domain 360 423 4.5E-15 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS03760 62037e30e884ac3cc0253601cc3a9af0 685 SUPERFAMILY SSF47384 414 495 1.59E-14 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS03760 62037e30e884ac3cc0253601cc3a9af0 685 Gene3D G3DSA:3.30.565.10 497 672 1.6E-48 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS03760 62037e30e884ac3cc0253601cc3a9af0 685 SMART SM00388 431 495 1.1E-13 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS03760 62037e30e884ac3cc0253601cc3a9af0 685 SUPERFAMILY SSF55874 484 670 2.23E-46 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS03760 62037e30e884ac3cc0253601cc3a9af0 685 Gene3D G3DSA:1.10.287.130 423 490 1.4E-13 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS03760 62037e30e884ac3cc0253601cc3a9af0 685 SMART SM00304 378 430 2.8E-11 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS03760 62037e30e884ac3cc0253601cc3a9af0 685 Pfam PF00512 His Kinase A (phospho-acceptor) domain 432 495 1.7E-12 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS03790 78f2c1c58620ddb904001b8f6b25f217 418 Gene3D G3DSA:3.40.50.300 42 189 5.1E-23 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03790 78f2c1c58620ddb904001b8f6b25f217 418 SMART SM00382 51 203 0.0056 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS03790 78f2c1c58620ddb904001b8f6b25f217 418 Pfam PF07728 AAA domain (dynein-related subfamily) 54 187 7.2E-9 T 09-03-2017 IPR011704 ATPase, dynein-related, AAA domain GO:0005524|GO:0016887 TK78_RS03790 78f2c1c58620ddb904001b8f6b25f217 418 SUPERFAMILY SSF52540 40 229 2.42E-21 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18740 0ab2e0e6f2a9cde90b3a5ed86a36f506 166 Gene3D G3DSA:3.40.630.30 3 155 5.6E-34 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS18740 0ab2e0e6f2a9cde90b3a5ed86a36f506 166 Pfam PF13302 Acetyltransferase (GNAT) domain 8 149 2.9E-22 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS18740 0ab2e0e6f2a9cde90b3a5ed86a36f506 166 SUPERFAMILY SSF55729 3 156 4.96E-30 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS13595 9648090e15b7261f08b16d1994af51e4 682 SUPERFAMILY SSF52540 18 208 2.5E-44 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13595 9648090e15b7261f08b16d1994af51e4 682 Gene3D G3DSA:1.10.150.80 560 626 7.4E-15 T 09-03-2017 IPR002121 HRDC domain GO:0003676|GO:0005622 TK78_RS13595 9648090e15b7261f08b16d1994af51e4 682 Pfam PF00570 HRDC domain 560 624 1.1E-20 T 09-03-2017 IPR002121 HRDC domain GO:0003676|GO:0005622 TK78_RS13595 9648090e15b7261f08b16d1994af51e4 682 Gene3D G3DSA:1.10.10.10 354 532 5.8E-53 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS13595 9648090e15b7261f08b16d1994af51e4 682 SMART SM00487 30 226 3.4E-25 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS13595 9648090e15b7261f08b16d1994af51e4 682 SMART SM00341 554 634 3.1E-13 T 09-03-2017 IPR002121 HRDC domain GO:0003676|GO:0005622 TK78_RS13595 9648090e15b7261f08b16d1994af51e4 682 SUPERFAMILY SSF52540 216 474 4.43E-60 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13595 9648090e15b7261f08b16d1994af51e4 682 Pfam PF16124 RecQ zinc-binding 352 415 1.7E-17 T 09-03-2017 IPR032284 ATP-dependent DNA helicase RecQ, zinc-binding domain TK78_RS13595 9648090e15b7261f08b16d1994af51e4 682 Pfam PF09382 RQC domain 417 531 1.2E-33 T 09-03-2017 IPR018982 RQC domain GO:0006260|GO:0006281|GO:0043140 Reactome: R-HSA-3108214|Reactome: R-HSA-5685938|Reactome: R-HSA-5685942|Reactome: R-HSA-5693554|Reactome: R-HSA-5693568|Reactome: R-HSA-5693579|Reactome: R-HSA-5693607|Reactome: R-HSA-5693616|Reactome: R-HSA-6804756|Reactome: R-HSA-69473 TK78_RS13595 9648090e15b7261f08b16d1994af51e4 682 Pfam PF00271 Helicase conserved C-terminal domain 233 340 2.8E-15 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS13595 9648090e15b7261f08b16d1994af51e4 682 Gene3D G3DSA:3.40.50.300 215 353 5.5E-49 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13595 9648090e15b7261f08b16d1994af51e4 682 TIGRFAM TIGR01389 recQ: ATP-dependent DNA helicase RecQ 22 626 3.9E-225 T 09-03-2017 IPR006293 DNA helicase, ATP-dependent, RecQ type, bacterial GO:0004003|GO:0006310|GO:0009432 TK78_RS13595 9648090e15b7261f08b16d1994af51e4 682 Gene3D G3DSA:3.40.50.300 17 212 2.1E-52 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13595 9648090e15b7261f08b16d1994af51e4 682 SUPERFAMILY SSF47819 553 626 3.71E-22 T 09-03-2017 IPR010997 HRDC-like GO:0000166|GO:0003824|GO:0044237 TK78_RS13595 9648090e15b7261f08b16d1994af51e4 682 SMART SM00956 422 528 1.8E-42 T 09-03-2017 IPR018982 RQC domain GO:0006260|GO:0006281|GO:0043140 Reactome: R-HSA-3108214|Reactome: R-HSA-5685938|Reactome: R-HSA-5685942|Reactome: R-HSA-5693554|Reactome: R-HSA-5693568|Reactome: R-HSA-5693579|Reactome: R-HSA-5693607|Reactome: R-HSA-5693616|Reactome: R-HSA-6804756|Reactome: R-HSA-69473 TK78_RS13595 9648090e15b7261f08b16d1994af51e4 682 SMART SM00490 259 340 1.8E-24 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS13595 9648090e15b7261f08b16d1994af51e4 682 Pfam PF00270 DEAD/DEAH box helicase 38 195 2.9E-15 T 09-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 TK78_RS13595 9648090e15b7261f08b16d1994af51e4 682 TIGRFAM TIGR00614 recQ_fam: ATP-dependent DNA helicase, RecQ family 24 477 3.3E-149 T 09-03-2017 IPR004589 DNA helicase, ATP-dependent, RecQ type GO:0006310|GO:0008026 TK78_RS08595 569c13bd28cb922bfc3c8702433f5ae8 315 SUPERFAMILY SSF51735 12 166 1.03E-29 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS08595 569c13bd28cb922bfc3c8702433f5ae8 315 Gene3D G3DSA:3.40.50.720 9 167 9.0E-33 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS08595 569c13bd28cb922bfc3c8702433f5ae8 315 Pfam PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase 12 164 1.2E-25 T 09-03-2017 IPR006115 6-phosphogluconate dehydrogenase, NADP-binding GO:0004616|GO:0055114 TK78_RS08595 569c13bd28cb922bfc3c8702433f5ae8 315 Gene3D G3DSA:1.10.1040.10 184 294 5.0E-5 T 09-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 TK78_RS08595 569c13bd28cb922bfc3c8702433f5ae8 315 PIRSF PIRSF000103 4 300 4.3E-41 T 09-03-2017 IPR015815 3-hydroxyisobutyrate dehydrogenase-related GO:0016491|GO:0055114 Reactome: R-HSA-70895 TK78_RS16390 78917244b4b767ab2a4ca7c873a995f5 753 Gene3D G3DSA:1.20.1640.10 531 733 7.2E-28 T 09-03-2017 TK78_RS16390 78917244b4b767ab2a4ca7c873a995f5 753 Gene3D G3DSA:1.20.1640.10 170 363 1.0E-32 T 09-03-2017 TK78_RS16390 78917244b4b767ab2a4ca7c873a995f5 753 SUPERFAMILY SSF82866 522 728 3.66E-23 T 09-03-2017 TK78_RS16390 78917244b4b767ab2a4ca7c873a995f5 753 SUPERFAMILY SSF82866 136 359 5.23E-31 T 09-03-2017 TK78_RS16390 78917244b4b767ab2a4ca7c873a995f5 753 Pfam PF03176 MMPL family 60 394 3.4E-59 T 09-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 TK78_RS16390 78917244b4b767ab2a4ca7c873a995f5 753 Pfam PF03176 MMPL family 478 728 3.0E-31 T 09-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 TK78_RS25470 6cb30a57758cc96555fab27b7d8dbd73 399 Pfam PF13556 PucR C-terminal helix-turn-helix domain 331 388 8.9E-20 T 09-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain TK78_RS28740 17f41ff50790323f2e15de0727b960ca 489 Hamap MF_00195 GTPase Der [der]. 51 483 35.27 T 09-03-2017 IPR016484 GTP-binding protein EngA GO:0005525 TK78_RS28740 17f41ff50790323f2e15de0727b960ca 489 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 227 393 1.6E-21 T 09-03-2017 IPR005225 Small GTP-binding protein domain GO:0005525 TK78_RS28740 17f41ff50790323f2e15de0727b960ca 489 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 54 173 2.9E-22 T 09-03-2017 IPR005225 Small GTP-binding protein domain GO:0005525 TK78_RS28740 17f41ff50790323f2e15de0727b960ca 489 Pfam PF01926 50S ribosome-binding GTPase 54 168 1.0E-24 T 09-03-2017 IPR006073 GTP binding domain GO:0005525 TK78_RS28740 17f41ff50790323f2e15de0727b960ca 489 Pfam PF01926 50S ribosome-binding GTPase 228 346 3.4E-21 T 09-03-2017 IPR006073 GTP binding domain GO:0005525 TK78_RS28740 17f41ff50790323f2e15de0727b960ca 489 PIRSF PIRSF006485 50 488 1.2E-156 T 09-03-2017 IPR016484 GTP-binding protein EngA GO:0005525 TK78_RS28740 17f41ff50790323f2e15de0727b960ca 489 SUPERFAMILY SSF52540 186 484 3.18E-59 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28740 17f41ff50790323f2e15de0727b960ca 489 Pfam PF14714 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal 402 480 1.2E-23 T 09-03-2017 IPR032859 GTPase Der, C-terminal KH-domain-like TK78_RS28740 17f41ff50790323f2e15de0727b960ca 489 Gene3D G3DSA:3.30.300.20 408 482 9.0E-27 T 09-03-2017 IPR015946 K homology domain-like, alpha/beta TK78_RS28740 17f41ff50790323f2e15de0727b960ca 489 SMART SM00382 50 214 0.23 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS28740 17f41ff50790323f2e15de0727b960ca 489 SMART SM00382 225 368 0.18 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS28740 17f41ff50790323f2e15de0727b960ca 489 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 229 249 1.5E-5 T 09-03-2017 IPR006073 GTP binding domain GO:0005525 TK78_RS28740 17f41ff50790323f2e15de0727b960ca 489 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 278 293 1.5E-5 T 09-03-2017 IPR006073 GTP binding domain GO:0005525 TK78_RS28740 17f41ff50790323f2e15de0727b960ca 489 Gene3D G3DSA:3.40.50.300 52 215 3.0E-40 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28740 17f41ff50790323f2e15de0727b960ca 489 Gene3D G3DSA:3.40.50.300 226 407 6.9E-45 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28740 17f41ff50790323f2e15de0727b960ca 489 SUPERFAMILY SSF52540 53 215 4.2E-42 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28740 17f41ff50790323f2e15de0727b960ca 489 TIGRFAM TIGR03594 GTPase_EngA: ribosome-associated GTPase EngA 52 480 1.6E-155 T 09-03-2017 IPR016484 GTP-binding protein EngA GO:0005525 TK78_RS08975 b6b07155cac9e74b7887c9d158f49c8b 371 SUPERFAMILY SSF103025 6 280 1.88E-96 T 09-03-2017 TK78_RS08975 b6b07155cac9e74b7887c9d158f49c8b 371 PIRSF PIRSF006487 1 371 1.4E-97 T 09-03-2017 IPR028896 Aminomethyltransferase/Dimethylsulfonioproprionate demethylase DmdA KEGG: 00260+2.1.2.10|KEGG: 00670+2.1.2.10|Reactome: R-HSA-6783984 TK78_RS08975 b6b07155cac9e74b7887c9d158f49c8b 371 Gene3D G3DSA:3.30.70.1400 56 143 3.1E-28 T 09-03-2017 TK78_RS08975 b6b07155cac9e74b7887c9d158f49c8b 371 Hamap MF_00259 Aminomethyltransferase [gcvT]. 4 369 44.42 T 09-03-2017 IPR022903 Glycine cleavage system T protein, bacteria GO:0004047|GO:0006546 KEGG: 00260+2.1.2.10|KEGG: 00670+2.1.2.10 TK78_RS08975 b6b07155cac9e74b7887c9d158f49c8b 371 TIGRFAM TIGR00528 gcvT: glycine cleavage system T protein 8 369 1.0E-106 T 09-03-2017 IPR006223 Glycine cleavage system T protein GO:0004047|GO:0006546 KEGG: 00260+2.1.2.10|KEGG: 00670+2.1.2.10|Reactome: R-HSA-6783984 TK78_RS08975 b6b07155cac9e74b7887c9d158f49c8b 371 Gene3D G3DSA:3.30.1360.120 6 55 7.7E-54 T 09-03-2017 IPR027266 GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1 GO:0005515 TK78_RS08975 b6b07155cac9e74b7887c9d158f49c8b 371 Gene3D G3DSA:3.30.1360.120 144 238 7.7E-54 T 09-03-2017 IPR027266 GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1 GO:0005515 TK78_RS08975 b6b07155cac9e74b7887c9d158f49c8b 371 SUPERFAMILY SSF101790 289 370 2.78E-24 T 09-03-2017 IPR029043 Glycine cleavage T-protein/YgfZ, C-terminal domain TK78_RS08975 b6b07155cac9e74b7887c9d158f49c8b 371 Gene3D G3DSA:2.40.30.110 287 363 5.1E-28 T 09-03-2017 IPR013977 Glycine cleavage T-protein, C-terminal barrel domain KEGG: 00260+2.1.2.10|KEGG: 00670+2.1.2.10 TK78_RS08975 b6b07155cac9e74b7887c9d158f49c8b 371 Pfam PF08669 Glycine cleavage T-protein C-terminal barrel domain 268 363 3.2E-24 T 09-03-2017 IPR013977 Glycine cleavage T-protein, C-terminal barrel domain KEGG: 00260+2.1.2.10|KEGG: 00670+2.1.2.10 TK78_RS08975 b6b07155cac9e74b7887c9d158f49c8b 371 Pfam PF01571 Aminomethyltransferase folate-binding domain 11 260 2.4E-92 T 09-03-2017 IPR006222 Glycine cleavage T-protein-like, N-terminal TK78_RS03545 3a77c13c5ffaea85731c24d80f463cca 404 Gene3D G3DSA:1.10.540.10 3 115 7.3E-26 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS03545 3a77c13c5ffaea85731c24d80f463cca 404 SUPERFAMILY SSF47203 254 401 3.7E-50 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS03545 3a77c13c5ffaea85731c24d80f463cca 404 Gene3D G3DSA:1.20.140.10 223 401 1.5E-61 T 09-03-2017 TK78_RS03545 3a77c13c5ffaea85731c24d80f463cca 404 SUPERFAMILY SSF56645 4 234 1.05E-57 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS03545 3a77c13c5ffaea85731c24d80f463cca 404 ProSitePatterns PS00073 Acyl-CoA dehydrogenases signature 2. 357 376 - T 09-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 TK78_RS03545 3a77c13c5ffaea85731c24d80f463cca 404 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 126 223 2.2E-24 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS03545 3a77c13c5ffaea85731c24d80f463cca 404 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 9 115 4.9E-17 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS03545 3a77c13c5ffaea85731c24d80f463cca 404 ProSitePatterns PS00072 Acyl-CoA dehydrogenases signature 1. 128 140 - T 09-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 TK78_RS03545 3a77c13c5ffaea85731c24d80f463cca 404 Gene3D G3DSA:2.40.110.10 125 222 7.5E-36 T 09-03-2017 TK78_RS03545 3a77c13c5ffaea85731c24d80f463cca 404 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 254 398 1.9E-49 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS17860 7f7056429e77fa9cbe86f2047643c309 133 SUPERFAMILY SSF55174 12 95 4.28E-21 T 09-03-2017 TK78_RS17860 7f7056429e77fa9cbe86f2047643c309 133 SMART SM00363 13 76 1.2E-7 T 09-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 TK78_RS17860 7f7056429e77fa9cbe86f2047643c309 133 Gene3D G3DSA:3.10.290.10 12 105 7.1E-28 T 09-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 TK78_RS17860 7f7056429e77fa9cbe86f2047643c309 133 Pfam PF01479 S4 domain 13 59 3.6E-11 T 09-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 TK78_RS17860 7f7056429e77fa9cbe86f2047643c309 133 PIRSF PIRSF016821 10 132 1.3E-43 T 09-03-2017 IPR025708 Heat shock protein 15 GO:0003677|GO:0003727|GO:0034605|GO:0043023 TK78_RS01095 436eb6d3597696e65e3a35464399eb48 638 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 29 183 1.9E-12 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS01095 436eb6d3597696e65e3a35464399eb48 638 PRINTS PR00775 90kDa heat shock protein signature 123 145 2.1E-58 T 09-03-2017 IPR020575 Heat shock protein Hsp90, N-terminal TK78_RS01095 436eb6d3597696e65e3a35464399eb48 638 PRINTS PR00775 90kDa heat shock protein signature 173 190 2.1E-58 T 09-03-2017 IPR020575 Heat shock protein Hsp90, N-terminal TK78_RS01095 436eb6d3597696e65e3a35464399eb48 638 PRINTS PR00775 90kDa heat shock protein signature 94 111 2.1E-58 T 09-03-2017 IPR020575 Heat shock protein Hsp90, N-terminal TK78_RS01095 436eb6d3597696e65e3a35464399eb48 638 PRINTS PR00775 90kDa heat shock protein signature 6 26 2.1E-58 T 09-03-2017 IPR020575 Heat shock protein Hsp90, N-terminal TK78_RS01095 436eb6d3597696e65e3a35464399eb48 638 PRINTS PR00775 90kDa heat shock protein signature 27 49 2.1E-58 T 09-03-2017 IPR020575 Heat shock protein Hsp90, N-terminal TK78_RS01095 436eb6d3597696e65e3a35464399eb48 638 PRINTS PR00775 90kDa heat shock protein signature 76 93 2.1E-58 T 09-03-2017 IPR020575 Heat shock protein Hsp90, N-terminal TK78_RS01095 436eb6d3597696e65e3a35464399eb48 638 PRINTS PR00775 90kDa heat shock protein signature 196 214 2.1E-58 T 09-03-2017 IPR020575 Heat shock protein Hsp90, N-terminal TK78_RS01095 436eb6d3597696e65e3a35464399eb48 638 Gene3D G3DSA:3.30.565.10 6 244 1.7E-77 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS01095 436eb6d3597696e65e3a35464399eb48 638 SUPERFAMILY SSF54211 237 490 4.25E-90 T 09-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold TK78_RS01095 436eb6d3597696e65e3a35464399eb48 638 PIRSF PIRSF002583 2 638 2.0E-213 T 09-03-2017 IPR001404 Heat shock protein Hsp90 family GO:0005524|GO:0006457|GO:0006950|GO:0051082 TK78_RS01095 436eb6d3597696e65e3a35464399eb48 638 SMART SM00387 28 185 3.6E-8 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS01095 436eb6d3597696e65e3a35464399eb48 638 Hamap MF_00505 Chaperone protein HtpG [htpG]. 3 635 29.188 T 09-03-2017 IPR001404 Heat shock protein Hsp90 family GO:0005524|GO:0006457|GO:0006950|GO:0051082 TK78_RS01095 436eb6d3597696e65e3a35464399eb48 638 SUPERFAMILY SSF55874 5 220 9.17E-62 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS01095 436eb6d3597696e65e3a35464399eb48 638 Pfam PF00183 Hsp90 protein 226 637 6.9E-127 T 09-03-2017 IPR001404 Heat shock protein Hsp90 family GO:0005524|GO:0006457|GO:0006950|GO:0051082 TK78_RS01095 436eb6d3597696e65e3a35464399eb48 638 SUPERFAMILY SSF110942 519 635 4.18E-31 T 09-03-2017 TK78_RS01095 436eb6d3597696e65e3a35464399eb48 638 ProSitePatterns PS00298 Heat shock hsp90 proteins family signature. 26 35 - T 09-03-2017 IPR019805 Heat shock protein Hsp90, conserved site GO:0005524|GO:0006457|GO:0006950|GO:0051082 TK78_RS18210 e02a07ce71bd146ea694d36351b1642a 278 PIRSF PIRSF006648 7 273 2.2E-17 T 09-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 TK78_RS18210 e02a07ce71bd146ea694d36351b1642a 278 Pfam PF01061 ABC-2 type transporter 32 239 9.0E-19 T 09-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 TK78_RS21235 cc2e4e4bcc9d2b6dd8e54c8f70866b97 370 Pfam PF07730 Histidine kinase 159 222 5.0E-11 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS21235 cc2e4e4bcc9d2b6dd8e54c8f70866b97 370 SUPERFAMILY SSF55874 262 363 5.27E-7 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS26015 3ec792457b3c2df4ae436d8ea141853d 482 SMART SM00955 53 373 1.5E-50 T 09-03-2017 TK78_RS26015 3ec792457b3c2df4ae436d8ea141853d 482 Pfam PF00773 RNB domain 57 363 9.0E-41 T 09-03-2017 TK78_RS26015 3ec792457b3c2df4ae436d8ea141853d 482 SUPERFAMILY SSF50249 19 416 2.0E-88 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS02490 fc3552b1b9dc2a3fe32e9897885a6f43 219 SUPERFAMILY SSF50475 43 163 4.97E-14 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS02490 fc3552b1b9dc2a3fe32e9897885a6f43 219 TIGRFAM TIGR04025 PPOX_FMN_DR2398: pyridoxamine 5'-phosphate oxidase, FMN-binding family 22 212 1.2E-61 T 09-03-2017 IPR024029 Pyridoxamine 5-phosphate oxidase, FMN-dependent TK78_RS02490 fc3552b1b9dc2a3fe32e9897885a6f43 219 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 43 136 1.6E-12 T 09-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS02490 fc3552b1b9dc2a3fe32e9897885a6f43 219 Gene3D G3DSA:2.30.110.10 36 161 3.9E-27 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS23465 34d7e5fce9eeea688449ed7bc4ad96c8 652 Gene3D G3DSA:3.30.1490.20 133 204 7.1E-25 T 09-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 TK78_RS23465 34d7e5fce9eeea688449ed7bc4ad96c8 652 Gene3D G3DSA:3.30.470.20 206 451 4.0E-98 T 09-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 TK78_RS23465 34d7e5fce9eeea688449ed7bc4ad96c8 652 SUPERFAMILY SSF52440 3 116 2.95E-48 T 09-03-2017 IPR016185 Pre-ATP-grasp domain TK78_RS23465 34d7e5fce9eeea688449ed7bc4ad96c8 652 Pfam PF02785 Biotin carboxylase C-terminal domain 341 447 1.7E-34 T 09-03-2017 IPR005482 Biotin carboxylase, C-terminal Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TK78_RS23465 34d7e5fce9eeea688449ed7bc4ad96c8 652 Pfam PF00289 Biotin carboxylase, N-terminal domain 4 113 4.7E-44 T 09-03-2017 IPR005481 Biotin carboxylase-like, N-terminal domain Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TK78_RS23465 34d7e5fce9eeea688449ed7bc4ad96c8 652 Gene3D G3DSA:3.40.50.20 4 132 1.9E-50 T 09-03-2017 IPR016185 Pre-ATP-grasp domain TK78_RS23465 34d7e5fce9eeea688449ed7bc4ad96c8 652 ProSitePatterns PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 291 298 - T 09-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 TK78_RS23465 34d7e5fce9eeea688449ed7bc4ad96c8 652 Pfam PF00364 Biotin-requiring enzyme 576 641 2.2E-18 T 09-03-2017 IPR000089 Biotin/lipoyl attachment TK78_RS23465 34d7e5fce9eeea688449ed7bc4ad96c8 652 SUPERFAMILY SSF51230 571 642 1.44E-20 T 09-03-2017 IPR011053 Single hybrid motif TK78_RS23465 34d7e5fce9eeea688449ed7bc4ad96c8 652 SUPERFAMILY SSF56059 86 353 4.24E-68 T 09-03-2017 TK78_RS23465 34d7e5fce9eeea688449ed7bc4ad96c8 652 Pfam PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 118 327 9.4E-78 T 09-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 TK78_RS23465 34d7e5fce9eeea688449ed7bc4ad96c8 652 SUPERFAMILY SSF51246 336 451 3.14E-37 T 09-03-2017 IPR011054 Rudiment single hybrid motif Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TK78_RS23465 34d7e5fce9eeea688449ed7bc4ad96c8 652 SMART SM00878 341 447 1.1E-53 T 09-03-2017 IPR005482 Biotin carboxylase, C-terminal Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TK78_RS23465 34d7e5fce9eeea688449ed7bc4ad96c8 652 ProSitePatterns PS00188 Biotin-requiring enzymes attachment site. 599 616 - T 09-03-2017 IPR001882 Biotin-binding site Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TK78_RS23465 34d7e5fce9eeea688449ed7bc4ad96c8 652 Gene3D G3DSA:2.40.50.100 574 642 1.8E-23 T 09-03-2017 TK78_RS20980 66f4759e8a5c6debba8da025aaf9a8d4 149 SUPERFAMILY SSF55729 1 135 1.66E-23 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS20980 66f4759e8a5c6debba8da025aaf9a8d4 149 Gene3D G3DSA:3.40.630.30 1 136 3.9E-22 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS20980 66f4759e8a5c6debba8da025aaf9a8d4 149 Pfam PF13302 Acetyltransferase (GNAT) domain 2 128 5.4E-17 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS34730 28ae097b2dcf8a4b407a6efb983145b3 65 Pfam PF00293 NUDIX domain 7 61 1.5E-9 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS34730 28ae097b2dcf8a4b407a6efb983145b3 65 SUPERFAMILY SSF55811 8 62 1.62E-11 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS34730 28ae097b2dcf8a4b407a6efb983145b3 65 Gene3D G3DSA:3.90.79.10 8 62 1.2E-10 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS06430 1a6e81653e321c71b4ddccf3d7335e37 411 Pfam PF02274 Amidinotransferase 17 407 1.5E-86 T 09-03-2017 TK78_RS06430 1a6e81653e321c71b4ddccf3d7335e37 411 Hamap MF_00242 Arginine deiminase [arcA]. 1 410 42.584 T 09-03-2017 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981 TK78_RS06430 1a6e81653e321c71b4ddccf3d7335e37 411 PIRSF PIRSF006356 1 410 4.2E-150 T 09-03-2017 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981 TK78_RS06430 1a6e81653e321c71b4ddccf3d7335e37 411 Gene3D G3DSA:3.75.10.10 2 66 1.9E-125 T 09-03-2017 TK78_RS06430 1a6e81653e321c71b4ddccf3d7335e37 411 Gene3D G3DSA:3.75.10.10 151 410 1.9E-125 T 09-03-2017 TK78_RS06430 1a6e81653e321c71b4ddccf3d7335e37 411 PRINTS PR01466 Bacterial arginine deiminase signature 151 169 3.3E-49 T 09-03-2017 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981 TK78_RS06430 1a6e81653e321c71b4ddccf3d7335e37 411 PRINTS PR01466 Bacterial arginine deiminase signature 179 194 3.3E-49 T 09-03-2017 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981 TK78_RS06430 1a6e81653e321c71b4ddccf3d7335e37 411 PRINTS PR01466 Bacterial arginine deiminase signature 346 363 3.3E-49 T 09-03-2017 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981 TK78_RS06430 1a6e81653e321c71b4ddccf3d7335e37 411 PRINTS PR01466 Bacterial arginine deiminase signature 389 407 3.3E-49 T 09-03-2017 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981 TK78_RS06430 1a6e81653e321c71b4ddccf3d7335e37 411 PRINTS PR01466 Bacterial arginine deiminase signature 1 20 3.3E-49 T 09-03-2017 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981 TK78_RS06430 1a6e81653e321c71b4ddccf3d7335e37 411 PRINTS PR01466 Bacterial arginine deiminase signature 366 380 3.3E-49 T 09-03-2017 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981 TK78_RS06430 1a6e81653e321c71b4ddccf3d7335e37 411 SUPERFAMILY SSF55909 2 410 1.88E-124 T 09-03-2017 TK78_RS15065 d63736b632bcfaeb083020c474a7bef9 83 ProSitePatterns PS00012 Phosphopantetheine attachment site. 31 46 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS15065 d63736b632bcfaeb083020c474a7bef9 83 SUPERFAMILY SSF47336 4 79 9.42E-16 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS15065 d63736b632bcfaeb083020c474a7bef9 83 Pfam PF00550 Phosphopantetheine attachment site 19 70 1.3E-10 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS15065 d63736b632bcfaeb083020c474a7bef9 83 Gene3D G3DSA:1.10.1200.10 4 81 2.8E-19 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31435 f1e5ede85d062630f2384e4edf5ef2a4 159 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 23 34 1.1E-14 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS31435 f1e5ede85d062630f2384e4edf5ef2a4 159 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 7 23 1.1E-14 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS31435 f1e5ede85d062630f2384e4edf5ef2a4 159 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 34 53 1.1E-14 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS31435 f1e5ede85d062630f2384e4edf5ef2a4 159 Pfam PF13404 AsnC-type helix-turn-helix domain 7 48 1.0E-16 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS31435 f1e5ede85d062630f2384e4edf5ef2a4 159 SUPERFAMILY SSF54909 69 153 8.31E-12 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS31435 f1e5ede85d062630f2384e4edf5ef2a4 159 SMART SM00344 7 116 4.3E-32 T 09-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 TK78_RS31435 f1e5ede85d062630f2384e4edf5ef2a4 159 Pfam PF01037 Lrp/AsnC ligand binding domain 74 146 1.4E-13 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS31435 f1e5ede85d062630f2384e4edf5ef2a4 159 SUPERFAMILY SSF46785 6 66 7.19E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS31435 f1e5ede85d062630f2384e4edf5ef2a4 159 Gene3D G3DSA:1.10.10.10 5 55 1.6E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS31435 f1e5ede85d062630f2384e4edf5ef2a4 159 Gene3D G3DSA:3.30.70.920 59 148 3.4E-18 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS10065 fe0f397c4aa3cf3f27b6657c0db45c8f 322 TIGRFAM TIGR01726 HEQRo_perm_3TM: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family 76 184 2.7E-18 T 09-03-2017 IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain GO:0005215|GO:0006810|GO:0016021 TK78_RS10065 fe0f397c4aa3cf3f27b6657c0db45c8f 322 Gene3D G3DSA:1.10.3720.10 74 290 1.9E-51 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS10065 fe0f397c4aa3cf3f27b6657c0db45c8f 322 SUPERFAMILY SSF161098 75 290 3.66E-45 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS10065 fe0f397c4aa3cf3f27b6657c0db45c8f 322 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 95 289 4.0E-24 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS10065 fe0f397c4aa3cf3f27b6657c0db45c8f 322 ProDom PD866859 YTVB PLASMID MEMBRANE TRANSMEMBRANE 118 209 0.006 T 09-03-2017 TK78_RS19230 9e8e9b8415aaebdd687cc0c9872e66d2 507 Gene3D G3DSA:1.20.200.10 227 389 1.8E-38 T 09-03-2017 TK78_RS19230 9e8e9b8415aaebdd687cc0c9872e66d2 507 Gene3D G3DSA:1.20.200.10 121 182 1.8E-38 T 09-03-2017 TK78_RS19230 9e8e9b8415aaebdd687cc0c9872e66d2 507 Pfam PF00206 Lyase 99 292 1.5E-23 T 09-03-2017 IPR022761 Fumarate lyase, N-terminal TK78_RS19230 9e8e9b8415aaebdd687cc0c9872e66d2 507 PRINTS PR00145 Argininosuccinate lyase family signature 231 255 8.1E-20 T 09-03-2017 TK78_RS19230 9e8e9b8415aaebdd687cc0c9872e66d2 507 PRINTS PR00145 Argininosuccinate lyase family signature 101 123 8.1E-20 T 09-03-2017 TK78_RS19230 9e8e9b8415aaebdd687cc0c9872e66d2 507 PRINTS PR00145 Argininosuccinate lyase family signature 275 291 8.1E-20 T 09-03-2017 TK78_RS19230 9e8e9b8415aaebdd687cc0c9872e66d2 507 PRINTS PR00145 Argininosuccinate lyase family signature 193 209 8.1E-20 T 09-03-2017 TK78_RS19230 9e8e9b8415aaebdd687cc0c9872e66d2 507 PRINTS PR00145 Argininosuccinate lyase family signature 142 162 8.1E-20 T 09-03-2017 TK78_RS19230 9e8e9b8415aaebdd687cc0c9872e66d2 507 SUPERFAMILY SSF48557 29 403 9.74E-59 T 09-03-2017 IPR008948 L-Aspartase-like GO:0003824 TK78_RS19230 9e8e9b8415aaebdd687cc0c9872e66d2 507 Gene3D G3DSA:1.10.275.10 30 120 1.4E-16 T 09-03-2017 IPR024083 Fumarase/histidase, N-terminal TK78_RS19230 9e8e9b8415aaebdd687cc0c9872e66d2 507 Gene3D G3DSA:1.10.275.10 192 226 1.4E-16 T 09-03-2017 IPR024083 Fumarase/histidase, N-terminal TK78_RS19230 9e8e9b8415aaebdd687cc0c9872e66d2 507 PRINTS PR00149 Fumarate lyase superfamily signature 102 120 2.4E-8 T 09-03-2017 IPR000362 Fumarate lyase family TK78_RS19230 9e8e9b8415aaebdd687cc0c9872e66d2 507 PRINTS PR00149 Fumarate lyase superfamily signature 231 258 2.4E-8 T 09-03-2017 IPR000362 Fumarate lyase family TK78_RS19230 9e8e9b8415aaebdd687cc0c9872e66d2 507 PRINTS PR00149 Fumarate lyase superfamily signature 275 291 2.4E-8 T 09-03-2017 IPR000362 Fumarate lyase family TK78_RS19230 9e8e9b8415aaebdd687cc0c9872e66d2 507 PRINTS PR00149 Fumarate lyase superfamily signature 147 165 2.4E-8 T 09-03-2017 IPR000362 Fumarate lyase family TK78_RS15345 28542eccafab2147c07dca982ca6b18d 267 Pfam PF00482 Type II secretion system (T2SS), protein F 126 248 1.2E-16 T 09-03-2017 IPR018076 Type II secretion system F domain TK78_RS26245 ea8c09c7627b9c3b2b08ddceff0c7753 423 Gene3D G3DSA:1.20.1250.20 5 192 1.3E-29 T 09-03-2017 TK78_RS26245 ea8c09c7627b9c3b2b08ddceff0c7753 423 Gene3D G3DSA:1.20.1250.20 194 374 1.0E-14 T 09-03-2017 TK78_RS26245 ea8c09c7627b9c3b2b08ddceff0c7753 423 Pfam PF07690 Major Facilitator Superfamily 9 339 7.0E-44 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS26245 ea8c09c7627b9c3b2b08ddceff0c7753 423 SUPERFAMILY SSF103473 3 374 6.02E-58 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS09635 0123d44e4c24e9360080467c7b1351be 190 Pfam PF01923 Cobalamin adenosyltransferase 7 174 5.2E-52 T 09-03-2017 IPR016030 Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase-like KEGG: 00860+2.5.1.17|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6268|MetaCyc: PWY-6269|Reactome: R-HSA-196741|Reactome: R-HSA-3359471 TK78_RS09635 0123d44e4c24e9360080467c7b1351be 190 ProDom PD007457 TRANSFERASE ADENOSYLTRANSFERASE COBALAMIN ATP:COBIALAMIN ADENOSYLTRANSFERASE PDUO TYPE RELATED ACIDURIA YVQK 13 184 5.0E-86 T 09-03-2017 IPR029499 ATP:cob(I)alamin adenosyltransferase, PduO-type KEGG: 00860+2.5.1.17|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6268|MetaCyc: PWY-6269|Reactome: R-HSA-196741|Reactome: R-HSA-3359471 TK78_RS09635 0123d44e4c24e9360080467c7b1351be 190 TIGRFAM TIGR00636 PduO_Nterm: ATP:cob(I)alamin adenosyltransferase 8 182 8.7E-48 T 09-03-2017 IPR029499 ATP:cob(I)alamin adenosyltransferase, PduO-type KEGG: 00860+2.5.1.17|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6268|MetaCyc: PWY-6269|Reactome: R-HSA-196741|Reactome: R-HSA-3359471 TK78_RS09635 0123d44e4c24e9360080467c7b1351be 190 Gene3D G3DSA:1.20.1200.10 16 188 2.3E-53 T 09-03-2017 IPR016030 Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase-like KEGG: 00860+2.5.1.17|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6268|MetaCyc: PWY-6269|Reactome: R-HSA-196741|Reactome: R-HSA-3359471 TK78_RS09635 0123d44e4c24e9360080467c7b1351be 190 SUPERFAMILY SSF89028 6 185 3.92E-53 T 09-03-2017 IPR016030 Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase-like KEGG: 00860+2.5.1.17|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6268|MetaCyc: PWY-6269|Reactome: R-HSA-196741|Reactome: R-HSA-3359471 TK78_RS05465 9daf2e6cc053375ac348d5635d19e42a 198 Pfam PF00583 Acetyltransferase (GNAT) family 88 174 4.4E-6 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS05465 9daf2e6cc053375ac348d5635d19e42a 198 SUPERFAMILY SSF55729 50 178 1.03E-18 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS05465 9daf2e6cc053375ac348d5635d19e42a 198 Gene3D G3DSA:3.40.630.30 59 178 3.3E-16 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS25630 d0a3ac9579db03d6ccee969d28c0f245 298 Gene3D G3DSA:2.60.60.30 17 171 1.3E-28 T 09-03-2017 TK78_RS25630 d0a3ac9579db03d6ccee969d28c0f245 298 Pfam PF02342 TerD domain 1 174 2.4E-42 T 09-03-2017 IPR003325 TerD domain GO:0006950 TK78_RS05935 740fa4fd354983e4e765d870beb20fb4 406 PIRSF PIRSF000429 3 400 8.6E-122 T 09-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 TK78_RS05935 740fa4fd354983e4e765d870beb20fb4 406 Gene3D G3DSA:3.40.47.10 152 191 8.9E-51 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS05935 740fa4fd354983e4e765d870beb20fb4 406 Gene3D G3DSA:3.40.47.10 280 398 8.9E-51 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS05935 740fa4fd354983e4e765d870beb20fb4 406 Pfam PF02803 Thiolase, C-terminal domain 275 397 2.8E-36 T 09-03-2017 IPR020617 Thiolase, C-terminal GO:0008152|GO:0016747 TK78_RS05935 740fa4fd354983e4e765d870beb20fb4 406 Pfam PF00108 Thiolase, N-terminal domain 8 266 6.3E-59 T 09-03-2017 IPR020616 Thiolase, N-terminal GO:0008152|GO:0016747 TK78_RS05935 740fa4fd354983e4e765d870beb20fb4 406 Gene3D G3DSA:3.40.47.10 7 131 2.7E-53 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS05935 740fa4fd354983e4e765d870beb20fb4 406 Gene3D G3DSA:3.40.47.10 192 278 2.7E-53 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS05935 740fa4fd354983e4e765d870beb20fb4 406 ProSitePatterns PS00737 Thiolases signature 2. 344 360 - T 09-03-2017 IPR020613 Thiolase, conserved site GO:0008152|GO:0016747 TK78_RS05935 740fa4fd354983e4e765d870beb20fb4 406 SUPERFAMILY SSF53901 277 397 3.13E-39 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS05935 740fa4fd354983e4e765d870beb20fb4 406 SUPERFAMILY SSF53901 7 273 1.24E-59 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS05935 740fa4fd354983e4e765d870beb20fb4 406 TIGRFAM TIGR01930 AcCoA-C-Actrans: acetyl-CoA C-acyltransferase 11 397 1.5E-132 T 09-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 TK78_RS34415 5f8a98f722849969eb57eb8237a502ee 309 SUPERFAMILY SSF47413 42 93 1.3E-9 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS34415 5f8a98f722849969eb57eb8237a502ee 309 Gene3D G3DSA:1.10.260.40 11 94 6.4E-19 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS34415 5f8a98f722849969eb57eb8237a502ee 309 Pfam PF13560 Helix-turn-helix domain 18 98 1.7E-17 T 09-03-2017 TK78_RS34415 5f8a98f722849969eb57eb8237a502ee 309 SMART SM00530 22 95 2.1E-9 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS31095 9ec90b7e201fccf60e8ccb43a2373690 307 Gene3D G3DSA:3.40.47.10 17 159 7.5E-39 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31095 9ec90b7e201fccf60e8ccb43a2373690 307 SUPERFAMILY SSF53901 5 171 1.18E-35 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31095 9ec90b7e201fccf60e8ccb43a2373690 307 SUPERFAMILY SSF53901 156 302 1.47E-19 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31095 9ec90b7e201fccf60e8ccb43a2373690 307 Pfam PF08545 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III 105 170 3.8E-21 T 09-03-2017 IPR013751 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 TK78_RS31095 9ec90b7e201fccf60e8ccb43a2373690 307 Pfam PF08541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal 227 302 1.7E-13 T 09-03-2017 IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, C-terminal KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 TK78_RS31095 9ec90b7e201fccf60e8ccb43a2373690 307 Gene3D G3DSA:3.40.47.10 160 302 8.0E-24 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS22180 996e89c9004ac08bed3f7d9884f2fd07 395 Pfam PF04464 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase 19 386 7.2E-120 T 09-03-2017 IPR007554 CDP-glycerol glycerophosphotransferase GO:0016020|GO:0047355 TK78_RS22180 996e89c9004ac08bed3f7d9884f2fd07 395 SUPERFAMILY SSF53756 178 386 1.46E-9 T 09-03-2017 TK78_RS03455 d1c7e3725bb2b07f2ae3bafcb1985a36 188 SUPERFAMILY SSF54427 61 177 1.34E-5 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS03455 d1c7e3725bb2b07f2ae3bafcb1985a36 188 Pfam PF13577 SnoaL-like domain 74 176 1.4E-4 T 09-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain TK78_RS30270 edc87d2923fdc5502b7c0600c326f14b 311 Gene3D G3DSA:3.40.50.300 132 303 4.1E-17 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS30270 edc87d2923fdc5502b7c0600c326f14b 311 Pfam PF13671 AAA domain 132 264 3.3E-8 T 09-03-2017 TK78_RS30270 edc87d2923fdc5502b7c0600c326f14b 311 SUPERFAMILY SSF52540 132 304 2.39E-14 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29645 b09c2f50a6cdef029c4c71512af41e2e 1598 Pfam PF05593 RHS Repeat 1242 1271 5.9E-6 T 09-03-2017 IPR031325 RHS repeat TK78_RS29645 b09c2f50a6cdef029c4c71512af41e2e 1598 Pfam PF05593 RHS Repeat 779 816 5.5E-9 T 09-03-2017 IPR031325 RHS repeat TK78_RS29645 b09c2f50a6cdef029c4c71512af41e2e 1598 Pfam PF05593 RHS Repeat 927 962 3.4E-8 T 09-03-2017 IPR031325 RHS repeat TK78_RS29645 b09c2f50a6cdef029c4c71512af41e2e 1598 Pfam PF05593 RHS Repeat 700 732 2.1E-6 T 09-03-2017 IPR031325 RHS repeat TK78_RS29645 b09c2f50a6cdef029c4c71512af41e2e 1598 Pfam PF05593 RHS Repeat 720 752 5.3E-7 T 09-03-2017 IPR031325 RHS repeat TK78_RS29645 b09c2f50a6cdef029c4c71512af41e2e 1598 Pfam PF05593 RHS Repeat 822 854 1.8E-5 T 09-03-2017 IPR031325 RHS repeat TK78_RS29645 b09c2f50a6cdef029c4c71512af41e2e 1598 Pfam PF05593 RHS Repeat 967 993 2.8E-5 T 09-03-2017 IPR031325 RHS repeat TK78_RS29645 b09c2f50a6cdef029c4c71512af41e2e 1598 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 1157 1190 2.9E-4 T 09-03-2017 IPR006530 YD repeat TK78_RS29645 b09c2f50a6cdef029c4c71512af41e2e 1598 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 967 1004 4.3E-5 T 09-03-2017 IPR006530 YD repeat TK78_RS29645 b09c2f50a6cdef029c4c71512af41e2e 1598 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 926 965 5.1E-7 T 09-03-2017 IPR006530 YD repeat TK78_RS29645 b09c2f50a6cdef029c4c71512af41e2e 1598 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 1242 1274 6.8E-7 T 09-03-2017 IPR006530 YD repeat TK78_RS29645 b09c2f50a6cdef029c4c71512af41e2e 1598 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 864 904 2.3E-5 T 09-03-2017 IPR006530 YD repeat TK78_RS29645 b09c2f50a6cdef029c4c71512af41e2e 1598 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 1048 1080 0.0016 T 09-03-2017 IPR006530 YD repeat TK78_RS29645 b09c2f50a6cdef029c4c71512af41e2e 1598 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 821 861 1.0E-7 T 09-03-2017 IPR006530 YD repeat TK78_RS29645 b09c2f50a6cdef029c4c71512af41e2e 1598 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 696 736 4.5E-8 T 09-03-2017 IPR006530 YD repeat TK78_RS29645 b09c2f50a6cdef029c4c71512af41e2e 1598 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 786 817 1.1E-7 T 09-03-2017 IPR006530 YD repeat TK78_RS29645 b09c2f50a6cdef029c4c71512af41e2e 1598 Pfam PF03527 RHS protein 1346 1374 2.8E-9 T 09-03-2017 IPR001826 RHS protein TK78_RS29645 b09c2f50a6cdef029c4c71512af41e2e 1598 TIGRFAM TIGR03696 Rhs_assc_core: RHS repeat-associated core domain 1370 1444 1.0E-22 T 09-03-2017 IPR022385 Rhs repeat-associated core GO:0097264 TK78_RS17660 515bcb63542d2cf27346acac648d2b85 380 Gene3D G3DSA:1.10.287.70 55 146 8.2E-14 T 09-03-2017 TK78_RS17660 515bcb63542d2cf27346acac648d2b85 380 SUPERFAMILY SSF51735 154 297 9.85E-27 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS17660 515bcb63542d2cf27346acac648d2b85 380 Pfam PF07885 Ion channel 55 138 2.0E-13 T 09-03-2017 IPR013099 Potassium channel domain TK78_RS17660 515bcb63542d2cf27346acac648d2b85 380 Pfam PF02254 TrkA-N domain 159 275 1.7E-26 T 09-03-2017 IPR003148 Regulator of K+ conductance, N-terminal GO:0006813 TK78_RS17660 515bcb63542d2cf27346acac648d2b85 380 Gene3D G3DSA:3.40.50.720 150 290 7.9E-33 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS17660 515bcb63542d2cf27346acac648d2b85 380 SUPERFAMILY SSF81324 47 169 1.96E-19 T 09-03-2017 TK78_RS13985 81b2021ab78c97384f402cb44a129c5c 367 Gene3D G3DSA:1.10.540.10 2 91 9.5E-16 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS13985 81b2021ab78c97384f402cb44a129c5c 367 SUPERFAMILY SSF47203 214 324 1.48E-28 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS13985 81b2021ab78c97384f402cb44a129c5c 367 Gene3D G3DSA:1.20.140.10 215 323 7.5E-26 T 09-03-2017 TK78_RS13985 81b2021ab78c97384f402cb44a129c5c 367 SUPERFAMILY SSF56645 2 94 1.03E-15 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS13985 81b2021ab78c97384f402cb44a129c5c 367 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 215 328 5.0E-22 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS13985 81b2021ab78c97384f402cb44a129c5c 367 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 6 93 1.4E-11 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS15890 8562c53c4eb38c4bc8b304c75c6e58a2 390 Pfam PF02767 DNA polymerase III beta subunit, central domain 133 246 5.9E-24 T 09-03-2017 IPR022637 DNA polymerase III, beta chain, central GO:0003887|GO:0006260|GO:0008408|GO:0009360 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS15890 8562c53c4eb38c4bc8b304c75c6e58a2 390 SUPERFAMILY SSF55979 133 250 4.4E-17 T 09-03-2017 TK78_RS15890 8562c53c4eb38c4bc8b304c75c6e58a2 390 PIRSF PIRSF000804 1 363 7.3E-67 T 09-03-2017 IPR001001 DNA polymerase III, beta chain GO:0003677|GO:0003887|GO:0006260|GO:0008408|GO:0009360 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS15890 8562c53c4eb38c4bc8b304c75c6e58a2 390 SUPERFAMILY SSF55979 255 356 5.76E-12 T 09-03-2017 TK78_RS15890 8562c53c4eb38c4bc8b304c75c6e58a2 390 Pfam PF02768 DNA polymerase III beta subunit, C-terminal domain 253 356 1.4E-13 T 09-03-2017 IPR022635 DNA polymerase III, beta chain, C-terminal GO:0003677|GO:0003887|GO:0006260|GO:0008408|GO:0009360 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS15890 8562c53c4eb38c4bc8b304c75c6e58a2 390 SUPERFAMILY SSF55979 1 124 3.7E-17 T 09-03-2017 TK78_RS15890 8562c53c4eb38c4bc8b304c75c6e58a2 390 Gene3D G3DSA:3.10.150.10 128 250 1.3E-25 T 09-03-2017 TK78_RS15890 8562c53c4eb38c4bc8b304c75c6e58a2 390 Gene3D G3DSA:3.10.150.10 1 125 1.4E-22 T 09-03-2017 TK78_RS15890 8562c53c4eb38c4bc8b304c75c6e58a2 390 SMART SM00480 17 368 2.2E-62 T 09-03-2017 IPR001001 DNA polymerase III, beta chain GO:0003677|GO:0003887|GO:0006260|GO:0008408|GO:0009360 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS15890 8562c53c4eb38c4bc8b304c75c6e58a2 390 TIGRFAM TIGR00663 dnan: DNA polymerase III, beta subunit 1 361 2.5E-62 T 09-03-2017 IPR001001 DNA polymerase III, beta chain GO:0003677|GO:0003887|GO:0006260|GO:0008408|GO:0009360 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS15890 8562c53c4eb38c4bc8b304c75c6e58a2 390 Gene3D G3DSA:3.10.150.10 258 386 7.5E-20 T 09-03-2017 TK78_RS15890 8562c53c4eb38c4bc8b304c75c6e58a2 390 Pfam PF00712 DNA polymerase III beta subunit, N-terminal domain 1 124 8.6E-26 T 09-03-2017 IPR022634 DNA polymerase III, beta chain, N-terminal GO:0003677|GO:0003887|GO:0006260|GO:0008408|GO:0009360 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS13520 4a243ba8639c0bcff595a692b9f02160 725 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 382 560 2.4E-27 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS13520 4a243ba8639c0bcff595a692b9f02160 725 Pfam PF08448 PAS fold 29 141 3.7E-13 T 09-03-2017 IPR013656 PAS fold-4 TK78_RS13520 4a243ba8639c0bcff595a692b9f02160 725 Pfam PF13581 Histidine kinase-like ATPase domain 595 695 4.0E-9 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS13520 4a243ba8639c0bcff595a692b9f02160 725 SUPERFAMILY SSF55874 607 691 1.44E-5 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS13520 4a243ba8639c0bcff595a692b9f02160 725 SUPERFAMILY SSF55785 22 137 2.47E-9 T 09-03-2017 IPR000014 PAS domain TK78_RS13520 4a243ba8639c0bcff595a692b9f02160 725 Gene3D G3DSA:3.30.450.40 153 336 2.7E-26 T 09-03-2017 IPR029016 GAF domain-like TK78_RS13520 4a243ba8639c0bcff595a692b9f02160 725 Pfam PF01590 GAF domain 252 328 1.8E-7 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS13520 4a243ba8639c0bcff595a692b9f02160 725 Gene3D G3DSA:3.30.450.20 22 139 9.4E-13 T 09-03-2017 TK78_RS13520 4a243ba8639c0bcff595a692b9f02160 725 SMART SM00065 161 338 6.3E-10 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS13520 4a243ba8639c0bcff595a692b9f02160 725 SMART SM00331 356 574 1.5E-12 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS13520 4a243ba8639c0bcff595a692b9f02160 725 SUPERFAMILY SSF55781 227 337 3.27E-14 T 09-03-2017 IPR029016 GAF domain-like TK78_RS05615 2323d4a7cf4f1e29b682c8a73904ba9c 237 Pfam PF00929 Exonuclease 9 178 7.5E-15 T 09-03-2017 IPR013520 Exonuclease, RNase T/DNA polymerase III TK78_RS05615 2323d4a7cf4f1e29b682c8a73904ba9c 237 SUPERFAMILY SSF53098 3 201 2.56E-44 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS05615 2323d4a7cf4f1e29b682c8a73904ba9c 237 SMART SM00479 7 188 1.0E-19 T 09-03-2017 IPR013520 Exonuclease, RNase T/DNA polymerase III TK78_RS05615 2323d4a7cf4f1e29b682c8a73904ba9c 237 Gene3D G3DSA:3.30.420.10 2 188 4.0E-39 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS16875 4a58d79d5da7e868d3fded48d07cb435 468 Gene3D G3DSA:3.40.50.300 160 376 3.7E-7 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS16875 4a58d79d5da7e868d3fded48d07cb435 468 SUPERFAMILY SSF52540 160 425 3.61E-11 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS16875 4a58d79d5da7e868d3fded48d07cb435 468 Pfam PF01580 FtsK/SpoIIIE family 174 361 3.3E-6 T 09-03-2017 IPR002543 FtsK domain GO:0000166|GO:0003677|GO:0005524 TK78_RS27040 480b887a6166632c2262294a44357c5d 805 Gene3D G3DSA:3.90.260.10 419 558 2.3E-23 T 09-03-2017 IPR002931 Transglutaminase-like TK78_RS27040 480b887a6166632c2262294a44357c5d 805 SMART SM00460 483 553 5.1E-20 T 09-03-2017 IPR002931 Transglutaminase-like TK78_RS27040 480b887a6166632c2262294a44357c5d 805 SUPERFAMILY SSF54001 411 559 7.15E-35 T 09-03-2017 TK78_RS27040 480b887a6166632c2262294a44357c5d 805 Pfam PF13559 Domain of unknown function (DUF4129) 672 744 2.3E-7 T 09-03-2017 IPR025403 Domain of unknown function DUF4129 TK78_RS27040 480b887a6166632c2262294a44357c5d 805 Pfam PF01841 Transglutaminase-like superfamily 436 551 4.2E-24 T 09-03-2017 IPR002931 Transglutaminase-like TK78_RS10375 8586c3016b78cd0f79688b98406753cb 502 SMART SM00471 252 387 1.9E-10 T 09-03-2017 IPR003607 HD/PDEase domain TK78_RS10375 8586c3016b78cd0f79688b98406753cb 502 Gene3D G3DSA:1.10.3210.10 249 420 2.1E-23 T 09-03-2017 IPR006674 HD domain TK78_RS10375 8586c3016b78cd0f79688b98406753cb 502 Pfam PF01966 HD domain 258 378 1.5E-19 T 09-03-2017 IPR006674 HD domain TK78_RS10375 8586c3016b78cd0f79688b98406753cb 502 TIGRFAM TIGR00277 HDIG: HDIG domain 257 346 2.5E-8 T 09-03-2017 IPR006675 HDIG domain TK78_RS10375 8586c3016b78cd0f79688b98406753cb 502 SUPERFAMILY SSF109604 239 415 8.85E-40 T 09-03-2017 TK78_RS14480 55661b6dd8833df05804b6f491d8da51 268 Gene3D G3DSA:3.40.50.150 6 267 2.3E-102 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS14480 55661b6dd8833df05804b6f491d8da51 268 PIRSF PIRSF017393 1 268 1.6E-94 T 09-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type TK78_RS14480 55661b6dd8833df05804b6f491d8da51 268 SUPERFAMILY SSF53335 18 253 2.67E-42 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS14480 55661b6dd8833df05804b6f491d8da51 268 Pfam PF04672 S-adenosyl methyltransferase 11 267 4.6E-99 T 09-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type TK78_RS03785 5b72101f0f96a078783b352e6f5ac0d0 412 SUPERFAMILY SSF53300 267 372 2.43E-9 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS03785 5b72101f0f96a078783b352e6f5ac0d0 412 Pfam PF13203 Putative metallopeptidase domain 13 267 1.9E-25 T 09-03-2017 IPR025154 Putative metallopeptidase domain TK78_RS03785 5b72101f0f96a078783b352e6f5ac0d0 412 Pfam PF09967 VWA-like domain (DUF2201) 273 377 5.0E-15 T 09-03-2017 IPR018698 VWA-like domain TK78_RS07865 25f1375ed712885f85434afbf8b4ad97 280 Gene3D G3DSA:3.40.630.30 128 276 1.8E-21 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS07865 25f1375ed712885f85434afbf8b4ad97 280 Pfam PF00583 Acetyltransferase (GNAT) family 207 270 6.8E-11 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS07865 25f1375ed712885f85434afbf8b4ad97 280 PIRSF PIRSF021603 1 280 5.4E-137 T 09-03-2017 IPR016794 Uncharacterised conserved protein UCP21603, acetyltransferase-like TK78_RS07865 25f1375ed712885f85434afbf8b4ad97 280 SUPERFAMILY SSF55729 6 275 4.08E-22 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS07865 25f1375ed712885f85434afbf8b4ad97 280 Pfam PF13312 Domain of unknown function (DUF4081) 47 151 6.9E-43 T 09-03-2017 IPR025289 Domain of unknown function DUF4081 TK78_RS11275 b37415e16bf73729b2adf3de9b468a3c 528 Gene3D G3DSA:2.60.120.260 428 528 5.9E-16 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS11275 b37415e16bf73729b2adf3de9b468a3c 528 Pfam PF05922 Peptidase inhibitor I9 58 124 4.2E-9 T 09-03-2017 IPR010259 Peptidase S8 propeptide/proteinase inhibitor I9 TK78_RS11275 b37415e16bf73729b2adf3de9b468a3c 528 Pfam PF00082 Subtilase family 159 388 2.1E-37 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS11275 b37415e16bf73729b2adf3de9b468a3c 528 ProSitePatterns PS00137 Serine proteases, subtilase family, histidine active site. 201 211 - T 09-03-2017 IPR022398 Peptidase S8, subtilisin, His-active site TK78_RS11275 b37415e16bf73729b2adf3de9b468a3c 528 SUPERFAMILY SSF49785 424 528 1.02E-23 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS11275 b37415e16bf73729b2adf3de9b468a3c 528 Gene3D G3DSA:3.40.50.200 134 399 1.3E-80 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS11275 b37415e16bf73729b2adf3de9b468a3c 528 PRINTS PR00723 Subtilisin serine protease family (S8) signature 350 366 6.2E-20 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS11275 b37415e16bf73729b2adf3de9b468a3c 528 PRINTS PR00723 Subtilisin serine protease family (S8) signature 197 210 6.2E-20 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS11275 b37415e16bf73729b2adf3de9b468a3c 528 PRINTS PR00723 Subtilisin serine protease family (S8) signature 159 178 6.2E-20 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS11275 b37415e16bf73729b2adf3de9b468a3c 528 Gene3D G3DSA:3.30.70.80 51 131 3.7E-16 T 09-03-2017 IPR010259 Peptidase S8 propeptide/proteinase inhibitor I9 TK78_RS11275 b37415e16bf73729b2adf3de9b468a3c 528 SUPERFAMILY SSF54897 57 125 2.95E-11 T 09-03-2017 IPR009020 Proteinase propeptide inhibitor TK78_RS11275 b37415e16bf73729b2adf3de9b468a3c 528 Pfam PF01483 Proprotein convertase P-domain 449 528 4.4E-19 T 09-03-2017 IPR002884 Proprotein convertase, P GO:0004252|GO:0006508 TK78_RS11275 b37415e16bf73729b2adf3de9b468a3c 528 ProSitePatterns PS00136 Serine proteases, subtilase family, aspartic acid active site. 164 175 - T 09-03-2017 IPR023827 Peptidase S8, subtilisin, Asp-active site TK78_RS11275 b37415e16bf73729b2adf3de9b468a3c 528 SUPERFAMILY SSF52743 132 400 9.16E-72 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS11275 b37415e16bf73729b2adf3de9b468a3c 528 ProSitePatterns PS00138 Serine proteases, subtilase family, serine active site. 351 361 - T 09-03-2017 IPR023828 Peptidase S8, subtilisin, Ser-active site TK78_RS21415 b0a48468d1bb9ab4713b4aabf060705f 205 Gene3D G3DSA:3.40.50.300 21 194 4.4E-17 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS21415 b0a48468d1bb9ab4713b4aabf060705f 205 PRINTS PR00449 Transforming protein P21 ras signature 81 103 9.9E-6 T 09-03-2017 TK78_RS21415 b0a48468d1bb9ab4713b4aabf060705f 205 PRINTS PR00449 Transforming protein P21 ras signature 23 44 9.9E-6 T 09-03-2017 TK78_RS21415 b0a48468d1bb9ab4713b4aabf060705f 205 PRINTS PR00449 Transforming protein P21 ras signature 171 193 9.9E-6 T 09-03-2017 TK78_RS21415 b0a48468d1bb9ab4713b4aabf060705f 205 SUPERFAMILY SSF52540 22 195 1.62E-24 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS21415 b0a48468d1bb9ab4713b4aabf060705f 205 Pfam PF03029 Conserved hypothetical ATP binding protein 27 193 4.6E-26 T 09-03-2017 IPR004130 GPN-loop GTPase TK78_RS19995 ed9eca3591a4d9ca412474d6b2ad297f 315 Pfam PF12710 haloacid dehalogenase-like hydrolase 65 251 1.7E-27 T 09-03-2017 TK78_RS19995 ed9eca3591a4d9ca412474d6b2ad297f 315 SUPERFAMILY SSF56784 64 277 2.27E-30 T 09-03-2017 IPR023214 HAD-like domain TK78_RS19995 ed9eca3591a4d9ca412474d6b2ad297f 315 TIGRFAM TIGR01488 HAD-SF-IB: HAD phosphoserine phosphatase-like hydrolase, family IB 64 254 2.8E-16 T 09-03-2017 IPR006383 HAD-superfamily hydrolase, subfamily IB, PSPase-like GO:0008152|GO:0016791 TK78_RS19995 ed9eca3591a4d9ca412474d6b2ad297f 315 Gene3D G3DSA:3.40.50.1000 137 281 7.1E-48 T 09-03-2017 IPR023214 HAD-like domain TK78_RS19995 ed9eca3591a4d9ca412474d6b2ad297f 315 TIGRFAM TIGR01490 HAD-SF-IB-hyp1: HAD hydrolase, family IB 64 266 8.8E-55 T 09-03-2017 IPR006385 HAD-superfamily hydrolase, subfamily IB, PSPase-like, bacterial TK78_RS15125 6155c75acf6b414705f15771fa212eb6 230 SUPERFAMILY SSF51182 21 166 4.45E-7 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS13255 b6473d97ace89eda1c6a30b1ea046d97 144 Pfam PF00298 Ribosomal protein L11, RNA binding domain 74 142 6.9E-25 T 09-03-2017 IPR020783 Ribosomal protein L11, C-terminal GO:0003735|GO:0005840|GO:0006412 TK78_RS13255 b6473d97ace89eda1c6a30b1ea046d97 144 Gene3D G3DSA:3.30.1550.10 5 74 1.3E-38 T 09-03-2017 IPR020784 Ribosomal protein L11, N-terminal TK78_RS13255 b6473d97ace89eda1c6a30b1ea046d97 144 TIGRFAM TIGR01632 L11_bact: ribosomal protein uL11 6 143 6.8E-63 T 09-03-2017 IPR006519 Ribosomal protein L11, bacterial-type GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13255 b6473d97ace89eda1c6a30b1ea046d97 144 Gene3D G3DSA:1.10.10.250 75 143 7.3E-32 T 09-03-2017 IPR020783 Ribosomal protein L11, C-terminal GO:0003735|GO:0005840|GO:0006412 TK78_RS13255 b6473d97ace89eda1c6a30b1ea046d97 144 ProSitePatterns PS00359 Ribosomal protein L11 signature. 129 144 - T 09-03-2017 IPR020785 Ribosomal protein L11, conserved site GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13255 b6473d97ace89eda1c6a30b1ea046d97 144 SUPERFAMILY SSF46906 70 143 1.7E-26 T 09-03-2017 IPR020783 Ribosomal protein L11, C-terminal GO:0003735|GO:0005840|GO:0006412 TK78_RS13255 b6473d97ace89eda1c6a30b1ea046d97 144 Pfam PF03946 Ribosomal protein L11, N-terminal domain 12 69 1.6E-29 T 09-03-2017 IPR020784 Ribosomal protein L11, N-terminal TK78_RS13255 b6473d97ace89eda1c6a30b1ea046d97 144 Hamap MF_00736 50S ribosomal protein L11 [rplK]. 8 144 31.693 T 09-03-2017 IPR000911 Ribosomal protein L11/L12 GO:0003735|GO:0005840|GO:0006412 TK78_RS13255 b6473d97ace89eda1c6a30b1ea046d97 144 ProDom PD001367 RIBOSOMAL RIBONUCLEOPROTEIN L11 RRNA-BINDING RNA-BINDING METHYLATION 50S L11 BACTERIAL CHLOROPLAST 39 76 2.0E-16 T 09-03-2017 TK78_RS13255 b6473d97ace89eda1c6a30b1ea046d97 144 SMART SM00649 12 143 4.4E-86 T 09-03-2017 IPR000911 Ribosomal protein L11/L12 GO:0003735|GO:0005840|GO:0006412 TK78_RS13255 b6473d97ace89eda1c6a30b1ea046d97 144 SUPERFAMILY SSF54747 5 75 2.88E-30 T 09-03-2017 IPR020784 Ribosomal protein L11, N-terminal TK78_RS02395 01aa0976e4182d1eed3af50df43b02fe 120 Pfam PF13466 STAS domain 24 101 8.8E-16 T 09-03-2017 IPR002645 STAS domain TK78_RS02395 01aa0976e4182d1eed3af50df43b02fe 120 Gene3D G3DSA:3.30.750.24 12 116 8.0E-23 T 09-03-2017 IPR002645 STAS domain TK78_RS02395 01aa0976e4182d1eed3af50df43b02fe 120 SUPERFAMILY SSF52091 13 115 2.35E-18 T 09-03-2017 IPR002645 STAS domain TK78_RS34185 3b97418d00ae21aed5456d7565863add 476 SMART SM00331 265 474 2.0E-19 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS34185 3b97418d00ae21aed5456d7565863add 476 SMART SM00086 170 212 4.2E-5 T 09-03-2017 IPR001610 PAC motif TK78_RS34185 3b97418d00ae21aed5456d7565863add 476 SUPERFAMILY SSF81606 280 474 1.52E-7 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS34185 3b97418d00ae21aed5456d7565863add 476 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 291 474 2.9E-44 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS34185 3b97418d00ae21aed5456d7565863add 476 Gene3D G3DSA:3.30.450.20 106 210 7.6E-14 T 09-03-2017 TK78_RS34185 3b97418d00ae21aed5456d7565863add 476 Pfam PF08447 PAS fold 120 199 4.3E-11 T 09-03-2017 IPR013655 PAS fold-3 GO:0005515 TK78_RS34185 3b97418d00ae21aed5456d7565863add 476 SUPERFAMILY SSF55785 120 218 4.67E-13 T 09-03-2017 IPR000014 PAS domain TK78_RS12385 6d238a9187ae5fe82793ef30c73ef3f1 259 Pfam PF00440 Bacterial regulatory proteins, tetR family 26 70 5.4E-20 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS12385 6d238a9187ae5fe82793ef30c73ef3f1 259 ProSitePatterns PS01081 TetR-type HTH domain signature. 38 69 - T 09-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site TK78_RS12385 6d238a9187ae5fe82793ef30c73ef3f1 259 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 47 70 7.1E-12 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS12385 6d238a9187ae5fe82793ef30c73ef3f1 259 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 26 39 7.1E-12 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS12385 6d238a9187ae5fe82793ef30c73ef3f1 259 Gene3D G3DSA:1.10.357.10 11 208 1.6E-35 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS12385 6d238a9187ae5fe82793ef30c73ef3f1 259 SUPERFAMILY SSF48498 93 233 4.14E-47 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS12385 6d238a9187ae5fe82793ef30c73ef3f1 259 SUPERFAMILY SSF46689 14 94 5.49E-22 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS06405 a04490e46394fcc3e3385e68f6a4a5ff 769 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 143 158 1.2E-12 T 09-03-2017 TK78_RS06405 a04490e46394fcc3e3385e68f6a4a5ff 769 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 273 288 1.2E-12 T 09-03-2017 TK78_RS06405 a04490e46394fcc3e3385e68f6a4a5ff 769 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 321 337 1.2E-12 T 09-03-2017 TK78_RS06405 a04490e46394fcc3e3385e68f6a4a5ff 769 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 16 38 1.2E-12 T 09-03-2017 TK78_RS06405 a04490e46394fcc3e3385e68f6a4a5ff 769 SUPERFAMILY SSF51905 16 164 9.64E-42 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS06405 a04490e46394fcc3e3385e68f6a4a5ff 769 SUPERFAMILY SSF51905 260 363 9.64E-42 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS06405 a04490e46394fcc3e3385e68f6a4a5ff 769 Gene3D G3DSA:3.20.20.70 394 735 3.3E-118 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS06405 a04490e46394fcc3e3385e68f6a4a5ff 769 Pfam PF01494 FAD binding domain 143 332 6.2E-12 T 09-03-2017 IPR002938 FAD-binding domain GO:0071949 TK78_RS06405 a04490e46394fcc3e3385e68f6a4a5ff 769 Pfam PF00724 NADH:flavin oxidoreductase / NADH oxidase family 397 730 2.3E-60 T 09-03-2017 IPR001155 NADH:flavin oxidoreductase/NADH oxidase, N-terminal GO:0010181|GO:0016491|GO:0055114 TK78_RS06405 a04490e46394fcc3e3385e68f6a4a5ff 769 SUPERFAMILY SSF51395 393 739 1.42E-113 T 09-03-2017 TK78_RS06405 a04490e46394fcc3e3385e68f6a4a5ff 769 Gene3D G3DSA:3.50.50.60 110 180 1.9E-47 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS06405 a04490e46394fcc3e3385e68f6a4a5ff 769 Gene3D G3DSA:3.50.50.60 16 56 1.9E-47 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS06405 a04490e46394fcc3e3385e68f6a4a5ff 769 Gene3D G3DSA:3.50.50.60 263 386 1.9E-47 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS21810 722faced03b1e9ac6ef1afea8db6f1ad 179 Pfam PF00731 AIR carboxylase 11 154 8.1E-65 T 09-03-2017 IPR000031 PurE domain GO:0006189 Reactome: R-HSA-73817 TK78_RS21810 722faced03b1e9ac6ef1afea8db6f1ad 179 TIGRFAM TIGR01162 purE: phosphoribosylaminoimidazole carboxylase, catalytic subunit 11 164 9.2E-63 T 09-03-2017 IPR000031 PurE domain GO:0006189 Reactome: R-HSA-73817 TK78_RS21810 722faced03b1e9ac6ef1afea8db6f1ad 179 Gene3D G3DSA:3.40.50.7700 6 166 4.7E-73 T 09-03-2017 IPR000031 PurE domain GO:0006189 Reactome: R-HSA-73817 TK78_RS21810 722faced03b1e9ac6ef1afea8db6f1ad 179 PIRSF PIRSF001338 6 169 2.9E-67 T 09-03-2017 IPR024694 PurE, prokaryotic type GO:0006189 KEGG: 00230+5.4.99.18|MetaCyc: PWY-6123|MetaCyc: PWY-7234 TK78_RS21810 722faced03b1e9ac6ef1afea8db6f1ad 179 SMART SM01001 9 158 5.5E-95 T 09-03-2017 IPR000031 PurE domain GO:0006189 Reactome: R-HSA-73817 TK78_RS21810 722faced03b1e9ac6ef1afea8db6f1ad 179 Hamap MF_01929 N5-carboxyaminoimidazole ribonucleotide mutase [purE]. 11 162 32.286 T 09-03-2017 IPR000031 PurE domain GO:0006189 Reactome: R-HSA-73817 TK78_RS21810 722faced03b1e9ac6ef1afea8db6f1ad 179 SUPERFAMILY SSF52255 10 168 5.49E-65 T 09-03-2017 IPR000031 PurE domain GO:0006189 Reactome: R-HSA-73817 TK78_RS32610 d634c2be63515f1be310919cf89551a8 225 Pfam PF03167 Uracil DNA glycosylase superfamily 55 211 7.5E-16 T 09-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 TK78_RS32610 d634c2be63515f1be310919cf89551a8 225 Gene3D G3DSA:3.40.470.10 5 224 4.6E-78 T 09-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 TK78_RS32610 d634c2be63515f1be310919cf89551a8 225 SMART SM00986 53 212 1.1E-25 T 09-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 TK78_RS32610 d634c2be63515f1be310919cf89551a8 225 SMART SM00987 53 212 1.1E-25 T 09-03-2017 TK78_RS32610 d634c2be63515f1be310919cf89551a8 225 SUPERFAMILY SSF52141 9 224 4.8E-69 T 09-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 TK78_RS32610 d634c2be63515f1be310919cf89551a8 225 Hamap MF_00148 Uracil-DNA glycosylase [ung]. 11 223 33.188 T 09-03-2017 IPR002043 Uracil-DNA glycosylase GO:0004844|GO:0006281|GO:0006284 Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 TK78_RS32610 d634c2be63515f1be310919cf89551a8 225 ProSitePatterns PS00130 Uracil-DNA glycosylase signature. 61 70 - T 09-03-2017 IPR018085 Uracil-DNA glycosylase, active site GO:0006281|GO:0016799 Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 TK78_RS04995 16c79ac7c42190d5faa4b46d1fe75575 178 TIGRFAM TIGR03180 UraD_2: OHCU decarboxylase 12 165 2.5E-55 T 09-03-2017 IPR017595 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase, type 2 TK78_RS04995 16c79ac7c42190d5faa4b46d1fe75575 178 SUPERFAMILY SSF158694 9 165 2.49E-39 T 09-03-2017 TK78_RS04995 16c79ac7c42190d5faa4b46d1fe75575 178 Pfam PF09349 OHCU decarboxylase 13 161 8.2E-34 T 09-03-2017 IPR018020 Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase KEGG: 00230+4.1.1.97|MetaCyc: PWY-5691|MetaCyc: PWY-7394 TK78_RS04995 16c79ac7c42190d5faa4b46d1fe75575 178 Gene3D G3DSA:1.10.3330.10 15 167 6.2E-41 T 09-03-2017 IPR018020 Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase KEGG: 00230+4.1.1.97|MetaCyc: PWY-5691|MetaCyc: PWY-7394 TK78_RS13025 c12d147cad01bd158ef684ab61896d24 340 SUPERFAMILY SSF55257 14 48 2.35E-24 T 09-03-2017 IPR009025 DNA-directed RNA polymerase, RBP11-like dimerisation domain GO:0006351|GO:0046983 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13025 c12d147cad01bd158ef684ab61896d24 340 SUPERFAMILY SSF55257 170 220 2.35E-24 T 09-03-2017 IPR009025 DNA-directed RNA polymerase, RBP11-like dimerisation domain GO:0006351|GO:0046983 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13025 c12d147cad01bd158ef684ab61896d24 340 Gene3D G3DSA:2.170.120.12 62 168 4.2E-45 T 09-03-2017 IPR011262 DNA-directed RNA polymerase, insert domain GO:0003899|GO:0006351|GO:0046983 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13025 c12d147cad01bd158ef684ab61896d24 340 ProDom PD001179 RNA POLYMERASE ALPHA DNA-DIRECTED SUBUNIT CHAIN NUCLEOTIDYLTRANSFERASE TRANSFERASE TRANSCRIPTION TRANSCRIPTASE 257 311 2.0E-24 T 09-03-2017 IPR011260 RNA polymerase, alpha subunit, C-terminal GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13025 c12d147cad01bd158ef684ab61896d24 340 Hamap MF_00059 DNA-directed RNA polymerase subunit alpha [rpoA]. 1 311 34.247 T 09-03-2017 IPR011773 DNA-directed RNA polymerase, alpha subunit GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13025 c12d147cad01bd158ef684ab61896d24 340 SMART SM00662 18 225 1.3E-94 T 09-03-2017 IPR011263 DNA-directed RNA polymerase, RpoA/D/Rpb3-type GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13025 c12d147cad01bd158ef684ab61896d24 340 Gene3D G3DSA:1.10.150.20 245 319 9.2E-32 T 09-03-2017 TK78_RS13025 c12d147cad01bd158ef684ab61896d24 340 TIGRFAM TIGR02027 rpoA: DNA-directed RNA polymerase, alpha subunit 19 310 3.4E-115 T 09-03-2017 IPR011773 DNA-directed RNA polymerase, alpha subunit GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13025 c12d147cad01bd158ef684ab61896d24 340 SUPERFAMILY SSF47789 247 318 1.83E-23 T 09-03-2017 TK78_RS13025 c12d147cad01bd158ef684ab61896d24 340 SUPERFAMILY SSF56553 48 169 4.97E-42 T 09-03-2017 IPR011262 DNA-directed RNA polymerase, insert domain GO:0003899|GO:0006351|GO:0046983 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13025 c12d147cad01bd158ef684ab61896d24 340 Gene3D G3DSA:3.30.1360.10 171 216 2.7E-4 T 09-03-2017 TK78_RS13025 c12d147cad01bd158ef684ab61896d24 340 Pfam PF03118 Bacterial RNA polymerase, alpha chain C terminal domain 245 302 5.9E-26 T 09-03-2017 IPR011260 RNA polymerase, alpha subunit, C-terminal GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13025 c12d147cad01bd158ef684ab61896d24 340 Pfam PF01193 RNA polymerase Rpb3/Rpb11 dimerisation domain 24 218 2.4E-19 T 09-03-2017 IPR009025 DNA-directed RNA polymerase, RBP11-like dimerisation domain GO:0006351|GO:0046983 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13025 c12d147cad01bd158ef684ab61896d24 340 Gene3D G3DSA:3.30.1360.10 7 61 5.7E-11 T 09-03-2017 TK78_RS13025 c12d147cad01bd158ef684ab61896d24 340 Pfam PF01000 RNA polymerase Rpb3/RpoA insert domain 57 149 5.8E-24 T 09-03-2017 IPR011262 DNA-directed RNA polymerase, insert domain GO:0003899|GO:0006351|GO:0046983 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS19310 44a9c83109edf22681ef9510308ac38b 334 SMART SM00382 43 226 2.9E-9 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS19310 44a9c83109edf22681ef9510308ac38b 334 Gene3D G3DSA:3.40.50.300 12 238 6.3E-66 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS19310 44a9c83109edf22681ef9510308ac38b 334 SUPERFAMILY SSF52540 19 237 1.04E-56 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS19310 44a9c83109edf22681ef9510308ac38b 334 ProSitePatterns PS00211 ABC transporters family signature. 150 164 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS19310 44a9c83109edf22681ef9510308ac38b 334 Pfam PF00005 ABC transporter 34 177 1.1E-24 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS27440 75d5724f5c4a563b4b0653ace898bbfb 344 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 6 115 7.2E-13 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS27440 75d5724f5c4a563b4b0653ace898bbfb 344 SUPERFAMILY SSF56645 1 123 2.68E-15 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS27440 75d5724f5c4a563b4b0653ace898bbfb 344 Gene3D G3DSA:1.20.140.10 195 342 1.7E-27 T 09-03-2017 TK78_RS27440 75d5724f5c4a563b4b0653ace898bbfb 344 SUPERFAMILY SSF47203 191 341 1.27E-30 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS27440 75d5724f5c4a563b4b0653ace898bbfb 344 Gene3D G3DSA:1.10.540.10 3 116 1.6E-13 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS27440 75d5724f5c4a563b4b0653ace898bbfb 344 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 192 340 5.6E-22 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS29465 ada3350f01ab0660384cdc2f112be2be 267 Pfam PF06966 Protein of unknown function (DUF1295) 28 256 9.7E-72 T 09-03-2017 IPR010721 Protein of unknown function DUF1295 TK78_RS07760 2266c4bceacc457c4470f4f7259181b0 317 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C 38 72 2.6E-7 T 09-03-2017 IPR025966 Oligopeptide transport permease C-like, N-terminal domain TK78_RS07760 2266c4bceacc457c4470f4f7259181b0 317 Gene3D G3DSA:1.10.3720.10 107 311 3.2E-28 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS07760 2266c4bceacc457c4470f4f7259181b0 317 SUPERFAMILY SSF161098 107 297 8.37E-28 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS07760 2266c4bceacc457c4470f4f7259181b0 317 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 129 313 1.4E-22 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS27840 76c21e8fec2203f7fbadafffadb3a83b 211 Pfam PF12385 Papain-like cysteine protease AvrRpt2 55 197 1.0E-16 T 09-03-2017 IPR022118 Peptidase C70, AvrRpt2 TK78_RS03335 52cb9b44543a16e5a0da8dfe0c950dff 396 Pfam PF03435 Saccharopine dehydrogenase NADP binding domain 13 141 2.4E-14 T 09-03-2017 IPR005097 Saccharopine dehydrogenase, NADP binding domain GO:0016491|GO:0055114 TK78_RS03335 52cb9b44543a16e5a0da8dfe0c950dff 396 Gene3D G3DSA:3.40.50.720 13 175 2.3E-18 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS03335 52cb9b44543a16e5a0da8dfe0c950dff 396 SUPERFAMILY SSF51735 12 167 5.81E-14 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07970 2889424825059776c6db65ab0969cc7a 344 Pfam PF00962 Adenosine/AMP deaminase 11 329 2.4E-90 T 09-03-2017 IPR001365 Adenosine/AMP deaminase domain GO:0019239 Reactome: R-HSA-74217 TK78_RS07970 2889424825059776c6db65ab0969cc7a 344 TIGRFAM TIGR01430 aden_deam: adenosine deaminase 11 330 5.9E-81 T 09-03-2017 IPR006330 Adenosine/adenine deaminase GO:0019239 Reactome: R-HSA-74217 TK78_RS07970 2889424825059776c6db65ab0969cc7a 344 Gene3D G3DSA:3.20.20.140 7 333 2.2E-95 T 09-03-2017 TK78_RS07970 2889424825059776c6db65ab0969cc7a 344 SUPERFAMILY SSF51556 7 334 1.97E-76 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS23475 ac7d297564f27a6da0fff475844277d5 205 SUPERFAMILY SSF46689 10 74 5.49E-17 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS23475 ac7d297564f27a6da0fff475844277d5 205 SUPERFAMILY SSF48498 90 173 1.78E-6 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS23475 ac7d297564f27a6da0fff475844277d5 205 Gene3D G3DSA:1.10.10.60 14 64 3.3E-20 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS23475 ac7d297564f27a6da0fff475844277d5 205 Pfam PF00440 Bacterial regulatory proteins, tetR family 18 64 8.5E-17 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS23475 ac7d297564f27a6da0fff475844277d5 205 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 39 62 6.2E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS23475 ac7d297564f27a6da0fff475844277d5 205 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 18 31 6.2E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS23475 ac7d297564f27a6da0fff475844277d5 205 Gene3D G3DSA:1.10.357.10 65 195 1.5E-23 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS28635 77dff793da5d8310553500ee94eaac42 208 SUPERFAMILY SSF55811 9 183 1.16E-42 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS28635 77dff793da5d8310553500ee94eaac42 208 Gene3D G3DSA:3.90.79.10 8 183 6.4E-47 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS28635 77dff793da5d8310553500ee94eaac42 208 Pfam PF00293 NUDIX domain 48 161 1.1E-15 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS23880 d35d9f6d3e8fd8c287833c5f7516be4c 741 Pfam PF14490 Helix-hairpin-helix containing domain 144 234 3.4E-31 T 09-03-2017 IPR029493 RecD helicase-like helix-hairpin-helix domain TK78_RS23880 d35d9f6d3e8fd8c287833c5f7516be4c 741 SUPERFAMILY SSF47781 85 162 3.71E-10 T 09-03-2017 IPR010994 RuvA domain 2-like TK78_RS23880 d35d9f6d3e8fd8c287833c5f7516be4c 741 Pfam PF13538 UvrD-like helicase C-terminal domain 658 706 2.7E-20 T 09-03-2017 IPR027785 UvrD-like helicase C-terminal domain TK78_RS23880 d35d9f6d3e8fd8c287833c5f7516be4c 741 SUPERFAMILY SSF52540 184 281 2.59E-44 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23880 d35d9f6d3e8fd8c287833c5f7516be4c 741 SUPERFAMILY SSF52540 332 483 2.59E-44 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23880 d35d9f6d3e8fd8c287833c5f7516be4c 741 SUPERFAMILY SSF52540 553 719 1.37E-55 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23880 d35d9f6d3e8fd8c287833c5f7516be4c 741 SUPERFAMILY SSF52540 445 512 1.37E-55 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23880 d35d9f6d3e8fd8c287833c5f7516be4c 741 Gene3D G3DSA:3.40.50.300 541 549 9.8E-20 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23880 d35d9f6d3e8fd8c287833c5f7516be4c 741 Gene3D G3DSA:3.40.50.300 651 710 9.8E-20 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23880 d35d9f6d3e8fd8c287833c5f7516be4c 741 Pfam PF14520 Helix-hairpin-helix domain 94 143 3.4E-7 T 09-03-2017 TK78_RS23880 d35d9f6d3e8fd8c287833c5f7516be4c 741 SMART SM00382 349 530 7.7E-4 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS23880 d35d9f6d3e8fd8c287833c5f7516be4c 741 Gene3D G3DSA:3.40.50.300 294 512 1.7E-43 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23880 d35d9f6d3e8fd8c287833c5f7516be4c 741 Gene3D G3DSA:1.10.150.20 94 162 9.0E-4 T 09-03-2017 TK78_RS23880 d35d9f6d3e8fd8c287833c5f7516be4c 741 Pfam PF13604 AAA domain 336 514 7.0E-45 T 09-03-2017 TK78_RS23880 d35d9f6d3e8fd8c287833c5f7516be4c 741 TIGRFAM TIGR01448 recD_rel: helicase, RecD/TraA family 8 729 1.3E-204 T 09-03-2017 IPR006345 DNA helicase, RecD-like GO:0003677|GO:0032508|GO:0043141 TK78_RS23880 d35d9f6d3e8fd8c287833c5f7516be4c 741 Hamap MF_01488 ATP-dependent RecD-like DNA helicase [recD2]. 4 735 28.851 T 09-03-2017 IPR006345 DNA helicase, RecD-like GO:0003677|GO:0032508|GO:0043141 TK78_RS09115 858a12aafed7a00aa0525a8cc5270ef6 418 SUPERFAMILY SSF55909 10 414 1.77E-131 T 09-03-2017 TK78_RS09115 858a12aafed7a00aa0525a8cc5270ef6 418 PRINTS PR01466 Bacterial arginine deiminase signature 372 386 9.2E-48 T 09-03-2017 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981 TK78_RS09115 858a12aafed7a00aa0525a8cc5270ef6 418 PRINTS PR01466 Bacterial arginine deiminase signature 395 413 9.2E-48 T 09-03-2017 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981 TK78_RS09115 858a12aafed7a00aa0525a8cc5270ef6 418 PRINTS PR01466 Bacterial arginine deiminase signature 8 28 9.2E-48 T 09-03-2017 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981 TK78_RS09115 858a12aafed7a00aa0525a8cc5270ef6 418 PRINTS PR01466 Bacterial arginine deiminase signature 352 369 9.2E-48 T 09-03-2017 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981 TK78_RS09115 858a12aafed7a00aa0525a8cc5270ef6 418 PRINTS PR01466 Bacterial arginine deiminase signature 159 177 9.2E-48 T 09-03-2017 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981 TK78_RS09115 858a12aafed7a00aa0525a8cc5270ef6 418 PRINTS PR01466 Bacterial arginine deiminase signature 187 202 9.2E-48 T 09-03-2017 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981 TK78_RS09115 858a12aafed7a00aa0525a8cc5270ef6 418 Hamap MF_00242 Arginine deiminase [arcA]. 7 416 46.952 T 09-03-2017 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981 TK78_RS09115 858a12aafed7a00aa0525a8cc5270ef6 418 PIRSF PIRSF006356 3 416 5.4E-130 T 09-03-2017 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981 TK78_RS09115 858a12aafed7a00aa0525a8cc5270ef6 418 Gene3D G3DSA:3.75.10.10 8 73 1.2E-122 T 09-03-2017 TK78_RS09115 858a12aafed7a00aa0525a8cc5270ef6 418 Gene3D G3DSA:3.75.10.10 159 416 1.2E-122 T 09-03-2017 TK78_RS09115 858a12aafed7a00aa0525a8cc5270ef6 418 Pfam PF02274 Amidinotransferase 24 413 7.9E-97 T 09-03-2017 TK78_RS23210 853d0792831526e67b97d890f87c0d4c 306 SUPERFAMILY SSF161098 39 306 2.83E-62 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS23210 853d0792831526e67b97d890f87c0d4c 306 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 122 292 3.6E-20 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS23210 853d0792831526e67b97d890f87c0d4c 306 Gene3D G3DSA:1.10.3720.10 39 291 2.7E-56 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS26755 420470db31ed3745b8b2427ff5aa2111 322 PRINTS PR01166 Cytochrome c oxidase subunit II signature 227 247 1.5E-14 T 09-03-2017 TK78_RS26755 420470db31ed3745b8b2427ff5aa2111 322 PRINTS PR01166 Cytochrome c oxidase subunit II signature 101 113 1.5E-14 T 09-03-2017 TK78_RS26755 420470db31ed3745b8b2427ff5aa2111 322 PRINTS PR01166 Cytochrome c oxidase subunit II signature 247 264 1.5E-14 T 09-03-2017 TK78_RS26755 420470db31ed3745b8b2427ff5aa2111 322 PRINTS PR01166 Cytochrome c oxidase subunit II signature 136 155 1.5E-14 T 09-03-2017 TK78_RS26755 420470db31ed3745b8b2427ff5aa2111 322 PRINTS PR01166 Cytochrome c oxidase subunit II signature 265 282 1.5E-14 T 09-03-2017 TK78_RS26755 420470db31ed3745b8b2427ff5aa2111 322 TIGRFAM TIGR02866 CoxB: cytochrome c oxidase, subunit II 54 291 4.6E-47 T 09-03-2017 IPR014222 Cytochrome c oxidase, subunit II GO:0016021|GO:0016491 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS26755 420470db31ed3745b8b2427ff5aa2111 322 Pfam PF00116 Cytochrome C oxidase subunit II, periplasmic domain 212 282 6.4E-18 T 09-03-2017 IPR002429 Cytochrome c oxidase subunit II C-terminal GO:0004129|GO:0005507|GO:0016020 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS26755 420470db31ed3745b8b2427ff5aa2111 322 Gene3D G3DSA:2.60.40.420 134 159 5.5E-40 T 09-03-2017 IPR008972 Cupredoxin TK78_RS26755 420470db31ed3745b8b2427ff5aa2111 322 Gene3D G3DSA:2.60.40.420 205 301 5.5E-40 T 09-03-2017 IPR008972 Cupredoxin TK78_RS26755 420470db31ed3745b8b2427ff5aa2111 322 SUPERFAMILY SSF81464 37 126 8.99E-18 T 09-03-2017 IPR011759 Cytochrome C oxidase subunit II, transmembrane domain GO:0016021|GO:0022900 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS26755 420470db31ed3745b8b2427ff5aa2111 322 Gene3D G3DSA:1.10.287.90 43 127 6.8E-15 T 09-03-2017 IPR011759 Cytochrome C oxidase subunit II, transmembrane domain GO:0016021|GO:0022900 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS26755 420470db31ed3745b8b2427ff5aa2111 322 ProSitePatterns PS00078 CO II and nitrous oxide reductase dinuclear copper centers signature. 228 276 - T 09-03-2017 IPR001505 Copper centre Cu(A) GO:0005507 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS26755 420470db31ed3745b8b2427ff5aa2111 322 SUPERFAMILY SSF49503 135 159 1.22E-40 T 09-03-2017 IPR008972 Cupredoxin TK78_RS26755 420470db31ed3745b8b2427ff5aa2111 322 SUPERFAMILY SSF49503 205 301 1.22E-40 T 09-03-2017 IPR008972 Cupredoxin TK78_RS12000 8d0dffff7bf6df783c7b98f1db025ad3 584 SUPERFAMILY SSF51230 511 582 1.31E-19 T 09-03-2017 IPR011053 Single hybrid motif TK78_RS12000 8d0dffff7bf6df783c7b98f1db025ad3 584 ProSitePatterns PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 285 292 - T 09-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 TK78_RS12000 8d0dffff7bf6df783c7b98f1db025ad3 584 Gene3D G3DSA:3.40.50.20 2 128 6.6E-49 T 09-03-2017 IPR016185 Pre-ATP-grasp domain TK78_RS12000 8d0dffff7bf6df783c7b98f1db025ad3 584 ProSitePatterns PS00188 Biotin-requiring enzymes attachment site. 539 556 - T 09-03-2017 IPR001882 Biotin-binding site Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TK78_RS12000 8d0dffff7bf6df783c7b98f1db025ad3 584 Pfam PF00364 Biotin-requiring enzyme 517 582 7.4E-17 T 09-03-2017 IPR000089 Biotin/lipoyl attachment TK78_RS12000 8d0dffff7bf6df783c7b98f1db025ad3 584 SUPERFAMILY SSF51246 328 442 6.28E-37 T 09-03-2017 IPR011054 Rudiment single hybrid motif Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TK78_RS12000 8d0dffff7bf6df783c7b98f1db025ad3 584 Pfam PF02785 Biotin carboxylase C-terminal domain 333 441 7.9E-36 T 09-03-2017 IPR005482 Biotin carboxylase, C-terminal Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TK78_RS12000 8d0dffff7bf6df783c7b98f1db025ad3 584 Gene3D G3DSA:3.30.1490.20 129 201 6.0E-20 T 09-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 TK78_RS12000 8d0dffff7bf6df783c7b98f1db025ad3 584 Gene3D G3DSA:2.40.50.100 512 583 1.5E-22 T 09-03-2017 TK78_RS12000 8d0dffff7bf6df783c7b98f1db025ad3 584 Gene3D G3DSA:3.30.470.20 202 444 6.9E-89 T 09-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 TK78_RS12000 8d0dffff7bf6df783c7b98f1db025ad3 584 Pfam PF00289 Biotin carboxylase, N-terminal domain 2 109 1.0E-43 T 09-03-2017 IPR005481 Biotin carboxylase-like, N-terminal domain Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TK78_RS12000 8d0dffff7bf6df783c7b98f1db025ad3 584 SMART SM00878 333 441 2.1E-56 T 09-03-2017 IPR005482 Biotin carboxylase, C-terminal Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TK78_RS12000 8d0dffff7bf6df783c7b98f1db025ad3 584 SUPERFAMILY SSF56059 114 321 3.36E-58 T 09-03-2017 TK78_RS12000 8d0dffff7bf6df783c7b98f1db025ad3 584 Pfam PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 114 320 2.4E-74 T 09-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 TK78_RS12000 8d0dffff7bf6df783c7b98f1db025ad3 584 SUPERFAMILY SSF52440 2 112 2.73E-45 T 09-03-2017 IPR016185 Pre-ATP-grasp domain TK78_RS26320 0c4fca48aaf49af7cda48f6f1a997faa 199 Gene3D G3DSA:1.10.357.10 61 197 3.7E-31 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS26320 0c4fca48aaf49af7cda48f6f1a997faa 199 Gene3D G3DSA:1.10.10.60 9 60 2.3E-17 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS26320 0c4fca48aaf49af7cda48f6f1a997faa 199 Pfam PF00440 Bacterial regulatory proteins, tetR family 24 63 3.9E-12 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS26320 0c4fca48aaf49af7cda48f6f1a997faa 199 SUPERFAMILY SSF46689 9 82 6.14E-16 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS26320 0c4fca48aaf49af7cda48f6f1a997faa 199 ProSitePatterns PS01081 TetR-type HTH domain signature. 34 65 - T 09-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site TK78_RS00565 3a64b063f29a45182b51c45841fed08b 394 SUPERFAMILY SSF52266 170 380 1.3E-25 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS00565 3a64b063f29a45182b51c45841fed08b 394 Gene3D G3DSA:3.40.50.1110 319 379 2.1E-8 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS00565 3a64b063f29a45182b51c45841fed08b 394 Gene3D G3DSA:3.40.50.1110 173 285 2.1E-8 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS00565 3a64b063f29a45182b51c45841fed08b 394 Pfam PF14606 GDSL-like Lipase/Acylhydrolase family 177 276 3.4E-12 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS10560 dd0de3775ec6c2d855c87b9346cc63de 374 Pfam PF00899 ThiF family 236 351 2.0E-5 T 09-03-2017 IPR000594 THIF-type NAD/FAD binding fold GO:0008641 TK78_RS10560 dd0de3775ec6c2d855c87b9346cc63de 374 Pfam PF00899 ThiF family 129 197 4.6E-7 T 09-03-2017 IPR000594 THIF-type NAD/FAD binding fold GO:0008641 TK78_RS10560 dd0de3775ec6c2d855c87b9346cc63de 374 SUPERFAMILY SSF69572 127 349 1.57E-10 T 09-03-2017 IPR000594 THIF-type NAD/FAD binding fold GO:0008641 TK78_RS10560 dd0de3775ec6c2d855c87b9346cc63de 374 Gene3D G3DSA:3.40.50.720 129 197 1.9E-5 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS23295 8ded9f3669738d0b950ef68b17e66975 514 Pfam PF08031 Berberine and berberine like 458 510 6.4E-18 T 09-03-2017 IPR012951 Berberine/berberine-like GO:0016491|GO:0050660|GO:0055114 TK78_RS23295 8ded9f3669738d0b950ef68b17e66975 514 Pfam PF01565 FAD binding domain 28 163 7.3E-21 T 09-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 TK78_RS23295 8ded9f3669738d0b950ef68b17e66975 514 SUPERFAMILY SSF56176 4 200 4.21E-38 T 09-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 TK78_RS23295 8ded9f3669738d0b950ef68b17e66975 514 Gene3D G3DSA:3.30.465.10 84 197 8.8E-9 T 09-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 TK78_RS12665 65e1261699271fa4df24e7494f7e0f5f 538 Pfam PF00171 Aldehyde dehydrogenase family 47 502 1.1E-141 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS12665 65e1261699271fa4df24e7494f7e0f5f 538 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 274 281 - T 09-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 TK78_RS12665 65e1261699271fa4df24e7494f7e0f5f 538 SUPERFAMILY SSF53720 41 505 1.07E-139 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS12665 65e1261699271fa4df24e7494f7e0f5f 538 Gene3D G3DSA:3.40.605.10 48 288 3.6E-70 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS12665 65e1261699271fa4df24e7494f7e0f5f 538 Gene3D G3DSA:3.40.309.10 289 465 2.4E-63 T 09-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 TK78_RS07435 88809dc5d70a8082778eb99739ecf331 333 TIGRFAM TIGR02122 TRAP_TAXI: TRAP transporter solute receptor, TAXI family 13 331 1.8E-82 T 09-03-2017 IPR011852 TRAP transporter solute receptor, TAXI family TK78_RS07435 88809dc5d70a8082778eb99739ecf331 333 Gene3D G3DSA:3.40.190.10 126 264 2.7E-37 T 09-03-2017 TK78_RS07435 88809dc5d70a8082778eb99739ecf331 333 SUPERFAMILY SSF53850 42 329 1.09E-60 T 09-03-2017 TK78_RS07435 88809dc5d70a8082778eb99739ecf331 333 Pfam PF16868 NMT1-like family 47 329 2.4E-47 T 09-03-2017 IPR011852 TRAP transporter solute receptor, TAXI family TK78_RS07435 88809dc5d70a8082778eb99739ecf331 333 Gene3D G3DSA:3.40.190.10 265 329 2.4E-26 T 09-03-2017 TK78_RS07435 88809dc5d70a8082778eb99739ecf331 333 Gene3D G3DSA:3.40.190.10 44 122 2.4E-26 T 09-03-2017 TK78_RS09695 f2e8fdd856a9fbb9b9049070f5b26960 76 Pfam PF00137 ATP synthase subunit C 17 73 4.1E-11 T 09-03-2017 IPR002379 V-ATPase proteolipid subunit C-like domain GO:0015078|GO:0015991|GO:0033177 TK78_RS09695 f2e8fdd856a9fbb9b9049070f5b26960 76 ProSitePatterns PS00605 ATP synthase c subunit signature. 40 61 - T 09-03-2017 IPR020537 ATPase, F0 complex, subunit C, DCCD-binding site Reactome: R-HSA-163210 TK78_RS09695 f2e8fdd856a9fbb9b9049070f5b26960 76 TIGRFAM TIGR01260 ATP_synt_c: ATP synthase F0, C subunit 20 69 4.2E-14 T 09-03-2017 IPR005953 ATPase, F0 complex, subunit C, bacterial/chloroplast GO:0015078|GO:0015986|GO:0045263 TK78_RS09695 f2e8fdd856a9fbb9b9049070f5b26960 76 Hamap MF_01396 ATP synthase subunit c [atpH]. 9 75 12.233 T 09-03-2017 TK78_RS09695 f2e8fdd856a9fbb9b9049070f5b26960 76 SUPERFAMILY SSF81333 15 74 1.27E-15 T 09-03-2017 IPR002379 V-ATPase proteolipid subunit C-like domain GO:0015078|GO:0015991|GO:0033177 TK78_RS09695 f2e8fdd856a9fbb9b9049070f5b26960 76 Gene3D G3DSA:1.20.20.10 14 73 5.5E-21 T 09-03-2017 IPR000454 ATPase, F0 complex, subunit C GO:0015078|GO:0015986|GO:0045263 Reactome: R-HSA-163210 TK78_RS09695 f2e8fdd856a9fbb9b9049070f5b26960 76 PRINTS PR00124 ATP synthase C subunit signature 33 48 3.9E-16 T 09-03-2017 IPR000454 ATPase, F0 complex, subunit C GO:0015078|GO:0015986|GO:0045263 Reactome: R-HSA-163210 TK78_RS09695 f2e8fdd856a9fbb9b9049070f5b26960 76 PRINTS PR00124 ATP synthase C subunit signature 50 75 3.9E-16 T 09-03-2017 IPR000454 ATPase, F0 complex, subunit C GO:0015078|GO:0015986|GO:0045263 Reactome: R-HSA-163210 TK78_RS09695 f2e8fdd856a9fbb9b9049070f5b26960 76 PRINTS PR00124 ATP synthase C subunit signature 12 31 3.9E-16 T 09-03-2017 IPR000454 ATPase, F0 complex, subunit C GO:0015078|GO:0015986|GO:0045263 Reactome: R-HSA-163210 TK78_RS17295 2da93170913632aed8640d7d07329d2e 576 Gene3D G3DSA:2.60.120.260 444 576 6.7E-9 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS17295 2da93170913632aed8640d7d07329d2e 576 SUPERFAMILY SSF56112 90 251 4.07E-11 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS17295 2da93170913632aed8640d7d07329d2e 576 SUPERFAMILY SSF49785 443 576 5.81E-8 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS17295 2da93170913632aed8640d7d07329d2e 576 Gene3D G3DSA:1.10.510.10 126 211 1.5E-7 T 09-03-2017 TK78_RS33295 1b0efa161f9cd3ff587bf1d7ddfc4ba5 460 ProSitePatterns PS00216 Sugar transport proteins signature 1. 74 91 - T 09-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 TK78_RS33295 1b0efa161f9cd3ff587bf1d7ddfc4ba5 460 SUPERFAMILY SSF103473 25 433 9.29E-22 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS33295 1b0efa161f9cd3ff587bf1d7ddfc4ba5 460 Gene3D G3DSA:1.20.1250.20 24 216 1.2E-8 T 09-03-2017 TK78_RS12915 8d18f884f162e3d0ba05f2a660246dd3 152 Gene3D G3DSA:1.10.10.10 10 149 6.5E-29 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS12915 8d18f884f162e3d0ba05f2a660246dd3 152 SMART SM00347 33 133 9.1E-11 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS12915 8d18f884f162e3d0ba05f2a660246dd3 152 PRINTS PR00598 Bacterial regulatory protein MarR family signature 74 89 4.4E-5 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS12915 8d18f884f162e3d0ba05f2a660246dd3 152 PRINTS PR00598 Bacterial regulatory protein MarR family signature 123 143 4.4E-5 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS12915 8d18f884f162e3d0ba05f2a660246dd3 152 PRINTS PR00598 Bacterial regulatory protein MarR family signature 57 73 4.4E-5 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS12915 8d18f884f162e3d0ba05f2a660246dd3 152 PRINTS PR00598 Bacterial regulatory protein MarR family signature 93 109 4.4E-5 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS12915 8d18f884f162e3d0ba05f2a660246dd3 152 Pfam PF13463 Winged helix DNA-binding domain 51 106 4.9E-8 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS12915 8d18f884f162e3d0ba05f2a660246dd3 152 SUPERFAMILY SSF46785 17 148 2.48E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS22095 84fcfeb4e2024189542cc442e76f3761 608 SMART SM00909 219 314 1.2E-8 T 09-03-2017 IPR019606 GerMN domain TK78_RS22095 84fcfeb4e2024189542cc442e76f3761 608 Pfam PF10647 Lipoprotein LpqB beta-propeller domain 352 603 1.8E-42 T 09-03-2017 IPR018910 Lipoprotein LpqB, beta-propeller domain, C-terminal TK78_RS22095 84fcfeb4e2024189542cc442e76f3761 608 SUPERFAMILY SSF82171 306 577 3.22E-8 T 09-03-2017 TK78_RS22095 84fcfeb4e2024189542cc442e76f3761 608 Pfam PF10646 Sporulation and spore germination 187 302 5.0E-9 T 09-03-2017 IPR019606 GerMN domain TK78_RS22095 84fcfeb4e2024189542cc442e76f3761 608 Gene3D G3DSA:2.120.10.30 338 572 1.7E-6 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS30455 b855d623351546c8c470ffe02376090d 366 TIGRFAM TIGR00227 ribD_Cterm: riboflavin-specific deaminase C-terminal domain 149 358 9.3E-56 T 09-03-2017 IPR011549 Riboflavin-specific deaminase, C-terminal GO:0008703|GO:0009231|GO:0050661|GO:0055114 TK78_RS30455 b855d623351546c8c470ffe02376090d 366 SUPERFAMILY SSF53597 148 356 1.19E-52 T 09-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 TK78_RS30455 b855d623351546c8c470ffe02376090d 366 Pfam PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region 7 103 8.4E-17 T 09-03-2017 IPR002125 Cytidine and deoxycytidylate deaminases, zinc-binding GO:0008270 TK78_RS30455 b855d623351546c8c470ffe02376090d 366 Pfam PF01872 RibD C-terminal domain 150 353 4.6E-49 T 09-03-2017 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 TK78_RS30455 b855d623351546c8c470ffe02376090d 366 PIRSF PIRSF006769 1 361 9.2E-123 T 09-03-2017 IPR004794 Riboflavin biosynthesis protein RibD GO:0008835|GO:0009231|GO:0055114 KEGG: 00040+1.1.1.19|KEGG: 00053+1.1.1.19|KEGG: 00740+3.5.4.26+1.1.1.193|MetaCyc: PWY-5525 TK78_RS30455 b855d623351546c8c470ffe02376090d 366 Gene3D G3DSA:3.40.140.10 6 130 5.0E-29 T 09-03-2017 TK78_RS30455 b855d623351546c8c470ffe02376090d 366 Gene3D G3DSA:3.40.430.10 131 357 2.2E-67 T 09-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 TK78_RS30455 b855d623351546c8c470ffe02376090d 366 SUPERFAMILY SSF53927 6 144 1.23E-41 T 09-03-2017 IPR016193 Cytidine deaminase-like GO:0003824 TK78_RS30455 b855d623351546c8c470ffe02376090d 366 TIGRFAM TIGR00326 eubact_ribD: riboflavin biosynthesis protein RibD 10 354 2.3E-110 T 09-03-2017 IPR004794 Riboflavin biosynthesis protein RibD GO:0008835|GO:0009231|GO:0055114 KEGG: 00040+1.1.1.19|KEGG: 00053+1.1.1.19|KEGG: 00740+3.5.4.26+1.1.1.193|MetaCyc: PWY-5525 TK78_RS30455 b855d623351546c8c470ffe02376090d 366 ProSitePatterns PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 54 92 - T 09-03-2017 IPR016192 APOBEC/CMP deaminase, zinc-binding GO:0008270|GO:0016787 TK78_RS08980 b30533b7999b47f319252f1cedb71268 125 Pfam PF01597 Glycine cleavage H-protein 7 122 7.8E-40 T 09-03-2017 IPR002930 Glycine cleavage system H-protein TK78_RS08980 b30533b7999b47f319252f1cedb71268 125 Gene3D G3DSA:2.40.50.100 6 123 2.1E-44 T 09-03-2017 TK78_RS08980 b30533b7999b47f319252f1cedb71268 125 SUPERFAMILY SSF51230 4 123 8.77E-38 T 09-03-2017 IPR011053 Single hybrid motif TK78_RS08980 b30533b7999b47f319252f1cedb71268 125 Hamap MF_00272 Glycine cleavage system H protein [gcvH]. 4 124 28.506 T 09-03-2017 IPR002930 Glycine cleavage system H-protein TK78_RS08980 b30533b7999b47f319252f1cedb71268 125 TIGRFAM TIGR00527 gcvH: glycine cleavage system H protein 3 121 1.1E-43 T 09-03-2017 IPR017453 Glycine cleavage system H-protein, subgroup GO:0005960|GO:0019464 Reactome: R-HSA-389661|Reactome: R-HSA-6783984 TK78_RS08980 b30533b7999b47f319252f1cedb71268 125 ProSitePatterns PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 48 77 - T 09-03-2017 IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site Reactome: R-HSA-389661 TK78_RS22470 c00903e85b818296b7e0fa86d57dc586 129 TIGRFAM TIGR01550 DOC_P1: death-on-curing family protein 47 117 1.8E-10 T 09-03-2017 IPR006440 Death on curing protein GO:0016301 TK78_RS22470 c00903e85b818296b7e0fa86d57dc586 129 Pfam PF02661 Fic/DOC family 6 85 4.1E-8 T 09-03-2017 IPR003812 Fido domain TK78_RS28465 d38d1fe3e7f65eae0f3307696099f236 258 Gene3D G3DSA:1.10.530.10 168 255 7.2E-9 T 09-03-2017 TK78_RS28465 d38d1fe3e7f65eae0f3307696099f236 258 Pfam PF01464 Transglycosylase SLT domain 183 255 1.4E-7 T 09-03-2017 IPR008258 Transglycosylase SLT domain 1 TK78_RS28465 d38d1fe3e7f65eae0f3307696099f236 258 SUPERFAMILY SSF53955 157 252 3.19E-13 T 09-03-2017 IPR023346 Lysozyme-like domain TK78_RS11195 02b38d36f130a61c8c482416ea1f0744 457 Gene3D G3DSA:3.40.605.10 3 242 2.1E-68 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS11195 02b38d36f130a61c8c482416ea1f0744 457 Gene3D G3DSA:3.40.309.10 243 428 3.3E-59 T 09-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 TK78_RS11195 02b38d36f130a61c8c482416ea1f0744 457 Pfam PF00171 Aldehyde dehydrogenase family 3 452 2.8E-136 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS11195 02b38d36f130a61c8c482416ea1f0744 457 SUPERFAMILY SSF53720 3 453 8.77E-143 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS10975 c26b5ff41a670c95f5bef5448b261845 382 ProSitePatterns PS00211 ABC transporters family signature. 198 212 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS10975 c26b5ff41a670c95f5bef5448b261845 382 SMART SM00382 82 275 1.4E-13 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS10975 c26b5ff41a670c95f5bef5448b261845 382 Gene3D G3DSA:3.40.50.300 44 299 2.3E-83 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10975 c26b5ff41a670c95f5bef5448b261845 382 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 278 344 1.8E-15 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS10975 c26b5ff41a670c95f5bef5448b261845 382 SUPERFAMILY SSF52540 45 297 2.18E-76 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10975 c26b5ff41a670c95f5bef5448b261845 382 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 276 354 1.9E-22 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS10975 c26b5ff41a670c95f5bef5448b261845 382 Pfam PF00005 ABC transporter 74 225 9.5E-34 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS13450 6006d1241c56c7dd0f01b13f2b32b019 357 SUPERFAMILY SSF52518 33 356 5.9E-86 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS13450 6006d1241c56c7dd0f01b13f2b32b019 357 Gene3D G3DSA:3.40.50.970 23 256 1.4E-84 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS13450 6006d1241c56c7dd0f01b13f2b32b019 357 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 69 216 1.4E-29 T 09-03-2017 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 TK78_RS21465 08828c720391d26bf096030427e5c7da 262 ProSitePatterns PS00211 ABC transporters family signature. 159 173 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS21465 08828c720391d26bf096030427e5c7da 262 Gene3D G3DSA:3.40.50.300 23 239 3.1E-67 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS21465 08828c720391d26bf096030427e5c7da 262 SMART SM00382 49 235 1.3E-15 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS21465 08828c720391d26bf096030427e5c7da 262 Pfam PF00005 ABC transporter 40 186 4.7E-32 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS21465 08828c720391d26bf096030427e5c7da 262 SUPERFAMILY SSF52540 23 239 2.23E-70 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31820 4edfe8d4f47f8c1de193226af56fe835 285 SUPERFAMILY SSF161098 82 267 2.88E-33 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS31820 4edfe8d4f47f8c1de193226af56fe835 285 Gene3D G3DSA:1.10.3720.10 80 275 5.5E-25 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS31820 4edfe8d4f47f8c1de193226af56fe835 285 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 104 273 1.7E-24 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS27460 cd547d48c6c8b8b06f941a4700936173 385 Pfam PF00108 Thiolase, N-terminal domain 5 255 1.6E-56 T 09-03-2017 IPR020616 Thiolase, N-terminal GO:0008152|GO:0016747 TK78_RS27460 cd547d48c6c8b8b06f941a4700936173 385 Gene3D G3DSA:3.40.47.10 160 195 1.7E-56 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS27460 cd547d48c6c8b8b06f941a4700936173 385 Gene3D G3DSA:3.40.47.10 269 384 1.7E-56 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS27460 cd547d48c6c8b8b06f941a4700936173 385 SUPERFAMILY SSF53901 3 262 1.06E-67 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS27460 cd547d48c6c8b8b06f941a4700936173 385 Pfam PF02803 Thiolase, C-terminal domain 263 384 1.3E-44 T 09-03-2017 IPR020617 Thiolase, C-terminal GO:0008152|GO:0016747 TK78_RS27460 cd547d48c6c8b8b06f941a4700936173 385 ProSitePatterns PS00737 Thiolases signature 2. 331 347 - T 09-03-2017 IPR020613 Thiolase, conserved site GO:0008152|GO:0016747 TK78_RS27460 cd547d48c6c8b8b06f941a4700936173 385 PIRSF PIRSF000429 1 385 7.0E-120 T 09-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 TK78_RS27460 cd547d48c6c8b8b06f941a4700936173 385 SUPERFAMILY SSF53901 263 384 3.3E-42 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS27460 cd547d48c6c8b8b06f941a4700936173 385 Gene3D G3DSA:3.40.47.10 196 268 1.2E-59 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS27460 cd547d48c6c8b8b06f941a4700936173 385 Gene3D G3DSA:3.40.47.10 4 124 1.2E-59 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS27460 cd547d48c6c8b8b06f941a4700936173 385 TIGRFAM TIGR01930 AcCoA-C-Actrans: acetyl-CoA C-acyltransferase 6 383 1.4E-124 T 09-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 TK78_RS28190 e6b53de49e6fbf883839e0f3ac0c744a 176 TIGRFAM TIGR02406 ectoine_EctA: diaminobutyrate acetyltransferase 18 174 2.1E-67 T 09-03-2017 IPR012772 L-2,4-diaminobutyric acid acetyltransferase GO:0019491|GO:0033816 KEGG: 00250+2.3.1.17|KEGG: 00260+2.3.1.178 TK78_RS28190 e6b53de49e6fbf883839e0f3ac0c744a 176 SUPERFAMILY SSF55729 16 138 4.65E-19 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS28190 e6b53de49e6fbf883839e0f3ac0c744a 176 Pfam PF00583 Acetyltransferase (GNAT) family 64 138 1.6E-12 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS28190 e6b53de49e6fbf883839e0f3ac0c744a 176 Gene3D G3DSA:3.40.630.30 17 175 4.8E-67 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS13005 e521e40d1d13baefc3be2e808a68fb19 539 SUPERFAMILY SSF52540 347 522 1.84E-29 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13005 e521e40d1d13baefc3be2e808a68fb19 539 SUPERFAMILY SSF52540 15 233 4.04E-36 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13005 e521e40d1d13baefc3be2e808a68fb19 539 Gene3D G3DSA:3.40.50.300 347 526 2.1E-28 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13005 e521e40d1d13baefc3be2e808a68fb19 539 Gene3D G3DSA:3.40.50.300 136 283 2.5E-38 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13005 e521e40d1d13baefc3be2e808a68fb19 539 Gene3D G3DSA:3.40.50.300 11 103 2.5E-38 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13005 e521e40d1d13baefc3be2e808a68fb19 539 Pfam PF00005 ABC transporter 348 475 1.2E-12 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS13005 e521e40d1d13baefc3be2e808a68fb19 539 Pfam PF00005 ABC transporter 21 191 3.0E-19 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS13005 e521e40d1d13baefc3be2e808a68fb19 539 SMART SM00382 356 536 8.1E-7 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS13005 e521e40d1d13baefc3be2e808a68fb19 539 SMART SM00382 29 236 2.7E-17 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS13525 f29cd5e03ad214681a9321b16cecb63e 1177 Pfam PF00931 NB-ARC domain 54 265 2.9E-7 T 09-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 TK78_RS13525 f29cd5e03ad214681a9321b16cecb63e 1177 Gene3D G3DSA:3.40.50.300 86 127 5.2E-4 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13525 f29cd5e03ad214681a9321b16cecb63e 1177 SMART SM00028 860 893 40.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS13525 f29cd5e03ad214681a9321b16cecb63e 1177 SMART SM00028 638 671 120.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS13525 f29cd5e03ad214681a9321b16cecb63e 1177 SMART SM00028 719 752 27.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS13525 f29cd5e03ad214681a9321b16cecb63e 1177 SMART SM00028 558 591 25.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS13525 f29cd5e03ad214681a9321b16cecb63e 1177 SMART SM00028 598 631 32.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS13525 f29cd5e03ad214681a9321b16cecb63e 1177 PRINTS PR00364 Disease resistance protein signature 160 174 1.7E-5 T 09-03-2017 TK78_RS13525 f29cd5e03ad214681a9321b16cecb63e 1177 PRINTS PR00364 Disease resistance protein signature 251 265 1.7E-5 T 09-03-2017 TK78_RS13525 f29cd5e03ad214681a9321b16cecb63e 1177 PRINTS PR00364 Disease resistance protein signature 74 89 1.7E-5 T 09-03-2017 TK78_RS13525 f29cd5e03ad214681a9321b16cecb63e 1177 SUPERFAMILY SSF52540 39 319 3.31E-22 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13525 f29cd5e03ad214681a9321b16cecb63e 1177 SUPERFAMILY SSF48452 853 1044 2.78E-16 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS13525 f29cd5e03ad214681a9321b16cecb63e 1177 Gene3D G3DSA:1.25.40.10 520 575 7.2E-4 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS13525 f29cd5e03ad214681a9321b16cecb63e 1177 SUPERFAMILY SSF48452 575 754 3.48E-19 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS13525 f29cd5e03ad214681a9321b16cecb63e 1177 Gene3D G3DSA:3.40.50.300 47 85 5.5E-5 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13525 f29cd5e03ad214681a9321b16cecb63e 1177 SUPERFAMILY SSF48452 493 587 2.47E-5 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS13525 f29cd5e03ad214681a9321b16cecb63e 1177 Gene3D G3DSA:1.25.40.10 576 783 3.6E-21 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS13525 f29cd5e03ad214681a9321b16cecb63e 1177 Gene3D G3DSA:1.25.40.10 852 1043 2.3E-15 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS13525 f29cd5e03ad214681a9321b16cecb63e 1177 Pfam PF13424 Tetratricopeptide repeat 600 664 2.4E-7 T 09-03-2017 TK78_RS06770 4a333e06b142b2618cf7e970dd24d28c 1961 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1413 1428 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS06770 4a333e06b142b2618cf7e970dd24d28c 1961 SUPERFAMILY SSF52777 1657 1927 5.89E-29 T 09-03-2017 TK78_RS06770 4a333e06b142b2618cf7e970dd24d28c 1961 Gene3D G3DSA:3.30.300.30 865 922 1.1E-35 T 09-03-2017 TK78_RS06770 4a333e06b142b2618cf7e970dd24d28c 1961 Gene3D G3DSA:3.30.300.30 1331 1393 1.1E-35 T 09-03-2017 TK78_RS06770 4a333e06b142b2618cf7e970dd24d28c 1961 Gene3D G3DSA:1.10.1200.10 1394 1453 2.9E-24 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS06770 4a333e06b142b2618cf7e970dd24d28c 1961 Gene3D G3DSA:2.30.38.10 783 859 1.6E-25 T 09-03-2017 TK78_RS06770 4a333e06b142b2618cf7e970dd24d28c 1961 SUPERFAMILY SSF52777 1464 1671 4.78E-32 T 09-03-2017 TK78_RS06770 4a333e06b142b2618cf7e970dd24d28c 1961 SMART SM00823 Phosphopantetheine attachment site 1389 1457 9.4E-9 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS06770 4a333e06b142b2618cf7e970dd24d28c 1961 SUPERFAMILY SSF47336 1383 1451 9.95E-19 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS06770 4a333e06b142b2618cf7e970dd24d28c 1961 SUPERFAMILY SSF52777 192 450 1.45E-36 T 09-03-2017 TK78_RS06770 4a333e06b142b2618cf7e970dd24d28c 1961 Pfam PF00550 Phosphopantetheine attachment site 1391 1451 1.0E-14 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS06770 4a333e06b142b2618cf7e970dd24d28c 1961 ProSitePatterns PS00455 Putative AMP-binding domain signature. 613 624 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS06770 4a333e06b142b2618cf7e970dd24d28c 1961 Pfam PF08241 Methyltransferase domain 989 1091 8.8E-11 T 09-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 TK78_RS06770 4a333e06b142b2618cf7e970dd24d28c 1961 SUPERFAMILY SSF53335 948 1094 1.16E-23 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS06770 4a333e06b142b2618cf7e970dd24d28c 1961 Gene3D G3DSA:3.40.50.980 635 782 1.8E-45 T 09-03-2017 TK78_RS06770 4a333e06b142b2618cf7e970dd24d28c 1961 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 485 894 1.5E-136 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS06770 4a333e06b142b2618cf7e970dd24d28c 1961 Pfam PF00668 Condensation domain 1490 1779 4.4E-36 T 09-03-2017 IPR001242 Condensation domain TK78_RS06770 4a333e06b142b2618cf7e970dd24d28c 1961 Pfam PF00668 Condensation domain 8 300 2.9E-45 T 09-03-2017 IPR001242 Condensation domain TK78_RS06770 4a333e06b142b2618cf7e970dd24d28c 1961 SUPERFAMILY SSF56801 1326 1402 1.83E-165 T 09-03-2017 TK78_RS06770 4a333e06b142b2618cf7e970dd24d28c 1961 SUPERFAMILY SSF56801 427 924 1.83E-165 T 09-03-2017 TK78_RS06770 4a333e06b142b2618cf7e970dd24d28c 1961 TIGRFAM TIGR01720 NRPS-para261: non-ribosomal peptide synthase domain TIGR01720 1795 1950 1.3E-44 T 09-03-2017 IPR010060 Non-ribosomal peptide synthase TK78_RS06770 4a333e06b142b2618cf7e970dd24d28c 1961 Gene3D G3DSA:3.40.50.980 457 634 3.5E-47 T 09-03-2017 TK78_RS06770 4a333e06b142b2618cf7e970dd24d28c 1961 Pfam PF00501 AMP-binding enzyme 464 870 5.9E-99 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS06770 4a333e06b142b2618cf7e970dd24d28c 1961 Gene3D G3DSA:3.40.50.150 955 1094 1.3E-21 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS06770 4a333e06b142b2618cf7e970dd24d28c 1961 SUPERFAMILY SSF52777 11 185 2.11E-33 T 09-03-2017 TK78_RS19610 b709ac7b371060a735acbb6900871f36 164 SUPERFAMILY SSF50324 3 156 9.03E-58 T 09-03-2017 IPR008162 Inorganic pyrophosphatase GO:0000287|GO:0004427|GO:0005737|GO:0006796 KEGG: 00190+3.6.1.1 TK78_RS19610 b709ac7b371060a735acbb6900871f36 164 Gene3D G3DSA:3.90.80.10 2 158 3.7E-54 T 09-03-2017 IPR008162 Inorganic pyrophosphatase GO:0000287|GO:0004427|GO:0005737|GO:0006796 KEGG: 00190+3.6.1.1 TK78_RS19610 b709ac7b371060a735acbb6900871f36 164 Pfam PF00719 Inorganic pyrophosphatase 5 157 4.1E-52 T 09-03-2017 IPR008162 Inorganic pyrophosphatase GO:0000287|GO:0004427|GO:0005737|GO:0006796 KEGG: 00190+3.6.1.1 TK78_RS19610 b709ac7b371060a735acbb6900871f36 164 ProSitePatterns PS00387 Inorganic pyrophosphatase signature. 52 58 - T 09-03-2017 IPR008162 Inorganic pyrophosphatase GO:0000287|GO:0004427|GO:0005737|GO:0006796 KEGG: 00190+3.6.1.1 TK78_RS19610 b709ac7b371060a735acbb6900871f36 164 Hamap MF_00209 Inorganic pyrophosphatase [ppa]. 1 158 32.677 T 09-03-2017 IPR008162 Inorganic pyrophosphatase GO:0000287|GO:0004427|GO:0005737|GO:0006796 KEGG: 00190+3.6.1.1 TK78_RS32655 4a3f46245f86608ac2bfed27e227cd60 231 Pfam PF01569 PAP2 superfamily 103 218 8.0E-20 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS32655 4a3f46245f86608ac2bfed27e227cd60 231 SMART SM00014 101 215 3.5E-12 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS32655 4a3f46245f86608ac2bfed27e227cd60 231 Gene3D G3DSA:1.20.144.10 32 220 4.2E-29 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS32655 4a3f46245f86608ac2bfed27e227cd60 231 SUPERFAMILY SSF48317 19 221 2.75E-33 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS26085 9602f0c046df0714aff279250201c5e2 269 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 174 193 5.1E-22 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS26085 9602f0c046df0714aff279250201c5e2 269 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 25 42 5.1E-22 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS26085 9602f0c046df0714aff279250201c5e2 269 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 97 108 5.1E-22 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS26085 9602f0c046df0714aff279250201c5e2 269 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 148 164 5.1E-22 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS26085 9602f0c046df0714aff279250201c5e2 269 Gene3D G3DSA:3.40.50.720 24 258 2.5E-63 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS26085 9602f0c046df0714aff279250201c5e2 269 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 154 162 1.9E-9 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS26085 9602f0c046df0714aff279250201c5e2 269 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 174 193 1.9E-9 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS26085 9602f0c046df0714aff279250201c5e2 269 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 97 108 1.9E-9 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS26085 9602f0c046df0714aff279250201c5e2 269 Pfam PF00106 short chain dehydrogenase 25 216 1.9E-50 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS26085 9602f0c046df0714aff279250201c5e2 269 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 161 189 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS26085 9602f0c046df0714aff279250201c5e2 269 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 24 205 0.0016 T 09-03-2017 TK78_RS26085 9602f0c046df0714aff279250201c5e2 269 SUPERFAMILY SSF51735 23 249 1.08E-60 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS23250 c5ced1560783f9a690c868b87c4a5945 490 Gene3D G3DSA:1.20.200.10 110 410 2.8E-92 T 09-03-2017 TK78_RS23250 c5ced1560783f9a690c868b87c4a5945 490 Gene3D G3DSA:1.10.40.30 411 483 3.7E-19 T 09-03-2017 TK78_RS23250 c5ced1560783f9a690c868b87c4a5945 490 Pfam PF10397 Adenylosuccinate lyase C-terminus 407 482 2.3E-12 T 09-03-2017 IPR019468 Adenylosuccinate lyase C-terminal KEGG: 00230+4.3.2.2|KEGG: 00250+4.3.2.2|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7219|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TK78_RS23250 c5ced1560783f9a690c868b87c4a5945 490 Pfam PF00206 Lyase 240 339 1.3E-10 T 09-03-2017 IPR022761 Fumarate lyase, N-terminal TK78_RS23250 c5ced1560783f9a690c868b87c4a5945 490 Pfam PF00206 Lyase 28 208 4.9E-19 T 09-03-2017 IPR022761 Fumarate lyase, N-terminal TK78_RS23250 c5ced1560783f9a690c868b87c4a5945 490 SMART SM00998 404 483 1.9E-14 T 09-03-2017 IPR019468 Adenylosuccinate lyase C-terminal KEGG: 00230+4.3.2.2|KEGG: 00250+4.3.2.2|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7219|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TK78_RS23250 c5ced1560783f9a690c868b87c4a5945 490 SUPERFAMILY SSF48557 244 485 5.01E-87 T 09-03-2017 IPR008948 L-Aspartase-like GO:0003824 TK78_RS23250 c5ced1560783f9a690c868b87c4a5945 490 SUPERFAMILY SSF48557 24 209 5.01E-87 T 09-03-2017 IPR008948 L-Aspartase-like GO:0003824 TK78_RS23250 c5ced1560783f9a690c868b87c4a5945 490 PRINTS PR00149 Fumarate lyase superfamily signature 316 332 1.0E-11 T 09-03-2017 IPR000362 Fumarate lyase family TK78_RS23250 c5ced1560783f9a690c868b87c4a5945 490 PRINTS PR00149 Fumarate lyase superfamily signature 107 125 1.0E-11 T 09-03-2017 IPR000362 Fumarate lyase family TK78_RS23250 c5ced1560783f9a690c868b87c4a5945 490 PRINTS PR00149 Fumarate lyase superfamily signature 152 170 1.0E-11 T 09-03-2017 IPR000362 Fumarate lyase family TK78_RS23250 c5ced1560783f9a690c868b87c4a5945 490 Gene3D G3DSA:1.10.275.10 16 109 8.7E-31 T 09-03-2017 IPR024083 Fumarase/histidase, N-terminal TK78_RS15960 e61ba882c61275ba0681c70fe3e0f7b1 305 Gene3D G3DSA:3.40.50.1820 18 300 2.1E-41 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS15960 e61ba882c61275ba0681c70fe3e0f7b1 305 SUPERFAMILY SSF53474 11 299 1.17E-37 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS15960 e61ba882c61275ba0681c70fe3e0f7b1 305 Pfam PF07859 alpha/beta hydrolase fold 122 200 2.0E-5 T 09-03-2017 IPR013094 Alpha/beta hydrolase fold-3 GO:0008152|GO:0016787 TK78_RS04505 0ec8e1eab2892d036e4279e501f7d0ac 321 SUPERFAMILY SSF53850 111 320 4.52E-26 T 09-03-2017 TK78_RS04505 0ec8e1eab2892d036e4279e501f7d0ac 321 Gene3D G3DSA:3.40.190.10 142 195 8.6E-6 T 09-03-2017 TK78_RS04505 0ec8e1eab2892d036e4279e501f7d0ac 321 SUPERFAMILY SSF46785 23 101 6.8E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS04505 0ec8e1eab2892d036e4279e501f7d0ac 321 Pfam PF03466 LysR substrate binding domain 111 318 3.9E-23 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS04505 0ec8e1eab2892d036e4279e501f7d0ac 321 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 51 61 7.7E-9 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS04505 0ec8e1eab2892d036e4279e501f7d0ac 321 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 40 51 7.7E-9 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS04505 0ec8e1eab2892d036e4279e501f7d0ac 321 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 61 72 7.7E-9 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS04505 0ec8e1eab2892d036e4279e501f7d0ac 321 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 25 83 2.6E-20 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS04505 0ec8e1eab2892d036e4279e501f7d0ac 321 Gene3D G3DSA:1.10.10.10 24 101 8.4E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS04505 0ec8e1eab2892d036e4279e501f7d0ac 321 Gene3D G3DSA:3.40.190.10 196 282 1.8E-18 T 09-03-2017 TK78_RS23790 0932de03375f8edf33badb1c134b44e8 383 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 50 134 4.5E-8 T 09-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 TK78_RS23790 0932de03375f8edf33badb1c134b44e8 383 Gene3D G3DSA:3.40.50.720 5 158 9.8E-27 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS23790 0932de03375f8edf33badb1c134b44e8 383 Gene3D G3DSA:3.30.360.10 159 374 4.0E-38 T 09-03-2017 TK78_RS23790 0932de03375f8edf33badb1c134b44e8 383 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 152 225 2.5E-5 T 09-03-2017 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 TK78_RS23790 0932de03375f8edf33badb1c134b44e8 383 SUPERFAMILY SSF51735 4 173 3.72E-30 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS23790 0932de03375f8edf33badb1c134b44e8 383 SUPERFAMILY SSF55347 146 346 3.92E-32 T 09-03-2017 TK78_RS31880 fbbcbf409c4760aa1c4bf0a6795432ab 344 Gene3D G3DSA:2.90.10.10 240 344 4.0E-23 T 09-03-2017 IPR001480 Bulb-type lectin domain TK78_RS31880 fbbcbf409c4760aa1c4bf0a6795432ab 344 SUPERFAMILY SSF51110 239 344 1.44E-20 T 09-03-2017 IPR001480 Bulb-type lectin domain TK78_RS31880 fbbcbf409c4760aa1c4bf0a6795432ab 344 SMART SM00108 241 344 4.9E-10 T 09-03-2017 IPR001480 Bulb-type lectin domain TK78_RS31880 fbbcbf409c4760aa1c4bf0a6795432ab 344 Pfam PF01453 D-mannose binding lectin 258 344 7.1E-15 T 09-03-2017 IPR001480 Bulb-type lectin domain TK78_RS10420 16007bceecc7a3fcc4c4970db33c8f32 394 SUPERFAMILY SSF56059 96 309 1.73E-30 T 09-03-2017 TK78_RS10420 16007bceecc7a3fcc4c4970db33c8f32 394 Gene3D G3DSA:3.30.470.20 98 381 2.7E-26 T 09-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 TK78_RS10420 16007bceecc7a3fcc4c4970db33c8f32 394 Pfam PF13535 ATP-grasp domain 141 274 1.7E-13 T 09-03-2017 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 Gene3D G3DSA:3.30.565.10 34 241 2.7E-86 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 Gene3D G3DSA:3.30.230.10 268 443 1.3E-70 T 09-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 61 201 9.7E-22 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 SMART SM00387 59 203 2.1E-21 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 PRINTS PR01159 DNA gyrase subunit B signature 425 445 1.7E-72 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 PRINTS PR01159 DNA gyrase subunit B signature 521 530 1.7E-72 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 PRINTS PR01159 DNA gyrase subunit B signature 659 675 1.7E-72 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 PRINTS PR01159 DNA gyrase subunit B signature 208 223 1.7E-72 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 PRINTS PR01159 DNA gyrase subunit B signature 223 236 1.7E-72 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 PRINTS PR01159 DNA gyrase subunit B signature 643 655 1.7E-72 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 PRINTS PR01159 DNA gyrase subunit B signature 293 311 1.7E-72 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 PRINTS PR01159 DNA gyrase subunit B signature 268 290 1.7E-72 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 PRINTS PR01159 DNA gyrase subunit B signature 363 379 1.7E-72 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 PRINTS PR01159 DNA gyrase subunit B signature 411 425 1.7E-72 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 PRINTS PR01159 DNA gyrase subunit B signature 34 44 1.7E-72 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 Pfam PF01751 Toprim domain 470 581 1.0E-16 T 09-03-2017 IPR006171 Toprim domain TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 Pfam PF00986 DNA gyrase B subunit, carboxyl terminus 621 679 1.7E-24 T 09-03-2017 IPR002288 DNA gyrase B subunit, C-terminal GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 Gene3D G3DSA:3.40.50.670 455 672 1.2E-87 T 09-03-2017 IPR013759 DNA topoisomerase, type IIA, central domain GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 SUPERFAMILY SSF56719 445 685 3.4E-82 T 09-03-2017 IPR013760 DNA topoisomerase, type IIA-like domain GO:0003918|GO:0005524 Reactome: R-HSA-4615885 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 SMART SM00433 63 683 0.0 T 09-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 PRINTS PR00418 DNA topoisomerase II family signature 537 553 3.3E-66 T 09-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 PRINTS PR00418 DNA topoisomerase II family signature 622 638 3.3E-66 T 09-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 PRINTS PR00418 DNA topoisomerase II family signature 471 485 3.3E-66 T 09-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 PRINTS PR00418 DNA topoisomerase II family signature 98 111 3.3E-66 T 09-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 PRINTS PR00418 DNA topoisomerase II family signature 63 78 3.3E-66 T 09-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 PRINTS PR00418 DNA topoisomerase II family signature 319 332 3.3E-66 T 09-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 PRINTS PR00418 DNA topoisomerase II family signature 575 587 3.3E-66 T 09-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 PRINTS PR00418 DNA topoisomerase II family signature 555 572 3.3E-66 T 09-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 PRINTS PR00418 DNA topoisomerase II family signature 141 155 3.3E-66 T 09-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 SUPERFAMILY SSF55874 34 238 7.67E-69 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 Pfam PF00204 DNA gyrase B 269 441 2.7E-61 T 09-03-2017 IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2 GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 ProSitePatterns PS00177 DNA topoisomerase II signature. 473 481 - T 09-03-2017 IPR018522 DNA topoisomerase, type IIA, conserved site GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 Hamap MF_01898 DNA gyrase subunit B [gyrB]. 31 690 88.272 T 09-03-2017 IPR011557 DNA gyrase, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0005694|GO:0006265 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 TIGRFAM TIGR01059 gyrB: DNA gyrase, B subunit 34 690 7.9E-283 T 09-03-2017 IPR011557 DNA gyrase, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0005694|GO:0006265 TK78_RS17395 08393facdfe66fc5028c9c42259c9bee 690 SUPERFAMILY SSF54211 269 442 1.67E-53 T 09-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold TK78_RS10140 16dd4930670e297353ee457a4d12e4ce 224 ProSitePatterns PS00622 LuxR-type HTH domain signature. 173 200 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS10140 16dd4930670e297353ee457a4d12e4ce 224 SUPERFAMILY SSF52172 4 138 6.83E-33 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS10140 16dd4930670e297353ee457a4d12e4ce 224 Pfam PF00196 Bacterial regulatory proteins, luxR family 159 213 6.5E-19 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS10140 16dd4930670e297353ee457a4d12e4ce 224 Gene3D G3DSA:3.40.50.2300 3 127 4.4E-38 T 09-03-2017 TK78_RS10140 16dd4930670e297353ee457a4d12e4ce 224 Gene3D G3DSA:1.10.10.10 128 220 5.8E-32 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS10140 16dd4930670e297353ee457a4d12e4ce 224 SMART SM00448 5 119 1.7E-30 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS10140 16dd4930670e297353ee457a4d12e4ce 224 SMART SM00421 156 213 2.6E-23 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS10140 16dd4930670e297353ee457a4d12e4ce 224 Pfam PF00072 Response regulator receiver domain 8 119 6.9E-25 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS10140 16dd4930670e297353ee457a4d12e4ce 224 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 159 173 4.4E-14 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS10140 16dd4930670e297353ee457a4d12e4ce 224 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 173 189 4.4E-14 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS10140 16dd4930670e297353ee457a4d12e4ce 224 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 189 201 4.4E-14 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS10140 16dd4930670e297353ee457a4d12e4ce 224 SUPERFAMILY SSF46894 147 219 6.12E-22 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS08955 aa74699478a94a0979aa9a9feba58bb1 556 Gene3D G3DSA:3.40.190.10 164 328 2.1E-36 T 09-03-2017 TK78_RS08955 aa74699478a94a0979aa9a9feba58bb1 556 Gene3D G3DSA:3.10.105.10 329 524 4.9E-43 T 09-03-2017 TK78_RS08955 aa74699478a94a0979aa9a9feba58bb1 556 PIRSF PIRSF002741 1 556 5.6E-84 T 09-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 TK78_RS08955 aa74699478a94a0979aa9a9feba58bb1 556 SUPERFAMILY SSF53850 37 556 8.82E-106 T 09-03-2017 TK78_RS08955 aa74699478a94a0979aa9a9feba58bb1 556 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 83 479 3.2E-76 T 09-03-2017 IPR000914 Solute-binding protein family 5 domain TK78_RS02305 5d45a9a58a1d04d001f20917ae3fba02 211 Pfam PF13490 Putative zinc-finger 10 37 2.6E-7 T 09-03-2017 IPR027383 Putative zinc-finger TK78_RS25410 4a0fc23e902bb090b43ab5173132afdc 143 Pfam PF12802 MarR family 35 91 2.9E-15 T 09-03-2017 TK78_RS25410 4a0fc23e902bb090b43ab5173132afdc 143 SUPERFAMILY SSF46785 6 138 1.73E-29 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS25410 4a0fc23e902bb090b43ab5173132afdc 143 Gene3D G3DSA:1.10.10.10 4 138 1.7E-33 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS25410 4a0fc23e902bb090b43ab5173132afdc 143 ProSitePatterns PS01117 MarR-type HTH domain signature. 67 101 - T 09-03-2017 IPR023187 Transcriptional regulator MarR-type, conserved site TK78_RS25410 4a0fc23e902bb090b43ab5173132afdc 143 PRINTS PR00598 Bacterial regulatory protein MarR family signature 88 104 2.0E-9 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS25410 4a0fc23e902bb090b43ab5173132afdc 143 PRINTS PR00598 Bacterial regulatory protein MarR family signature 69 84 2.0E-9 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS25410 4a0fc23e902bb090b43ab5173132afdc 143 PRINTS PR00598 Bacterial regulatory protein MarR family signature 117 137 2.0E-9 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS25410 4a0fc23e902bb090b43ab5173132afdc 143 SMART SM00347 29 127 1.9E-19 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS17960 17e0b02615c19b2fc2a9302717576fdd 156 PIRSF PIRSF005028 1 156 3.1E-48 T 09-03-2017 IPR026278 Potassium/proton antiporter subunit KhtT TK78_RS17960 17e0b02615c19b2fc2a9302717576fdd 156 SUPERFAMILY SSF116726 73 153 1.26E-14 T 09-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 TK78_RS17960 17e0b02615c19b2fc2a9302717576fdd 156 Pfam PF02080 TrkA-C domain 87 153 1.2E-10 T 09-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 TK78_RS17960 17e0b02615c19b2fc2a9302717576fdd 156 Gene3D G3DSA:3.30.70.1450 80 152 1.2E-17 T 09-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 TK78_RS14715 df8dc59d64f4546ec10f2619a3966d3b 195 Gene3D G3DSA:1.10.357.10 14 193 1.7E-39 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS14715 df8dc59d64f4546ec10f2619a3966d3b 195 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 45 68 6.2E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS14715 df8dc59d64f4546ec10f2619a3966d3b 195 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 25 38 6.2E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS14715 df8dc59d64f4546ec10f2619a3966d3b 195 Pfam PF00440 Bacterial regulatory proteins, tetR family 26 70 7.1E-14 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS14715 df8dc59d64f4546ec10f2619a3966d3b 195 SUPERFAMILY SSF46689 13 94 1.6E-19 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS14715 df8dc59d64f4546ec10f2619a3966d3b 195 SUPERFAMILY SSF48498 91 193 2.18E-8 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS14210 ef566b5d456417a0453e2221e615c313 389 SUPERFAMILY SSF47203 230 387 2.26E-38 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS14210 ef566b5d456417a0453e2221e615c313 389 Gene3D G3DSA:2.40.110.10 125 222 3.0E-27 T 09-03-2017 TK78_RS14210 ef566b5d456417a0453e2221e615c313 389 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 125 219 3.1E-17 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS14210 ef566b5d456417a0453e2221e615c313 389 SUPERFAMILY SSF56645 9 245 1.44E-63 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS14210 ef566b5d456417a0453e2221e615c313 389 Gene3D G3DSA:1.10.540.10 10 121 3.3E-31 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS14210 ef566b5d456417a0453e2221e615c313 389 Gene3D G3DSA:1.20.140.10 223 388 1.4E-45 T 09-03-2017 TK78_RS14210 ef566b5d456417a0453e2221e615c313 389 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 10 120 2.6E-29 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS14210 ef566b5d456417a0453e2221e615c313 389 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 234 373 1.0E-30 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS06345 48204e6d36d571ff09c9c5ecc503ae5f 130 Pfam PF04066 Multiple resistance and pH regulation protein F (MrpF / PhaF) 38 88 2.4E-11 T 09-03-2017 IPR007208 Na(+)/H(+) antiporter subunit F-like GO:0015075|GO:0016021|GO:0034220 TK78_RS19115 7763426f62da834673883e5d503a0f59 466 SMART SM00840 341 403 7.6E-15 T 09-03-2017 IPR015273 Cysteinyl-tRNA synthetase, class Ia, DALR GO:0000166|GO:0004817|GO:0005524|GO:0005737|GO:0006423 KEGG: 00970+6.1.1.16 TK78_RS19115 7763426f62da834673883e5d503a0f59 466 Pfam PF01406 tRNA synthetases class I (C) catalytic domain 17 311 7.9E-119 T 09-03-2017 IPR032678 tRNA synthetases class I, catalytic domain KEGG: 00970+6.1.1.16 TK78_RS19115 7763426f62da834673883e5d503a0f59 466 SUPERFAMILY SSF47323 330 463 4.45E-31 T 09-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS19115 7763426f62da834673883e5d503a0f59 466 Gene3D G3DSA:3.40.50.620 23 303 4.3E-95 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS19115 7763426f62da834673883e5d503a0f59 466 SUPERFAMILY SSF52374 4 310 9.12E-88 T 09-03-2017 TK78_RS19115 7763426f62da834673883e5d503a0f59 466 Hamap MF_00041 Cysteine--tRNA ligase [cysS]. 3 464 35.182 T 09-03-2017 IPR015803 Cysteine-tRNA ligase GO:0004817|GO:0005524|GO:0006423 KEGG: 00970+6.1.1.16 TK78_RS19115 7763426f62da834673883e5d503a0f59 466 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 62 71 2.9E-27 T 09-03-2017 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 TK78_RS19115 7763426f62da834673883e5d503a0f59 466 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 190 208 2.9E-27 T 09-03-2017 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 TK78_RS19115 7763426f62da834673883e5d503a0f59 466 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 221 242 2.9E-27 T 09-03-2017 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 TK78_RS19115 7763426f62da834673883e5d503a0f59 466 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 26 37 2.9E-27 T 09-03-2017 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 TK78_RS19115 7763426f62da834673883e5d503a0f59 466 Gene3D G3DSA:1.20.120.640 304 393 3.9E-19 T 09-03-2017 TK78_RS19115 7763426f62da834673883e5d503a0f59 466 TIGRFAM TIGR00435 cysS: cysteine--tRNA ligase 4 462 5.3E-137 T 09-03-2017 IPR015803 Cysteine-tRNA ligase GO:0004817|GO:0005524|GO:0006423 KEGG: 00970+6.1.1.16 TK78_RS19115 7763426f62da834673883e5d503a0f59 466 Pfam PF09190 DALR domain 341 394 7.9E-10 T 09-03-2017 IPR015273 Cysteinyl-tRNA synthetase, class Ia, DALR GO:0000166|GO:0004817|GO:0005524|GO:0005737|GO:0006423 KEGG: 00970+6.1.1.16 TK78_RS26745 eccaa24d0dcdeb177f1e86c5dccdf238 324 Gene3D G3DSA:3.40.1190.20 2 308 9.9E-44 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS26745 eccaa24d0dcdeb177f1e86c5dccdf238 324 SUPERFAMILY SSF53613 2 296 9.35E-52 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS26745 eccaa24d0dcdeb177f1e86c5dccdf238 324 Pfam PF00294 pfkB family carbohydrate kinase 32 295 5.8E-36 T 09-03-2017 IPR011611 Carbohydrate kinase PfkB TK78_RS08775 3916cdd42f3968ab8f0c757e1f94fee9 175 SUPERFAMILY SSF55021 82 162 7.63E-25 T 09-03-2017 TK78_RS08775 3916cdd42f3968ab8f0c757e1f94fee9 175 TIGRFAM TIGR00119 acolac_sm: acetolactate synthase, small subunit 4 159 2.2E-61 T 09-03-2017 IPR004789 Acetolactate synthase, small subunit GO:0003984|GO:0009082 KEGG: 00290+2.2.1.6|KEGG: 00650+2.2.1.6|KEGG: 00660+2.2.1.6|KEGG: 00770+2.2.1.6|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-5938|MetaCyc: PWY-5939|MetaCyc: PWY-6389|MetaCyc: PWY-7111 TK78_RS08775 3916cdd42f3968ab8f0c757e1f94fee9 175 Gene3D G3DSA:3.30.70.1150 85 164 2.3E-30 T 09-03-2017 TK78_RS08775 3916cdd42f3968ab8f0c757e1f94fee9 175 Gene3D G3DSA:3.30.70.260 3 79 2.5E-34 T 09-03-2017 TK78_RS08775 3916cdd42f3968ab8f0c757e1f94fee9 175 Pfam PF10369 Small subunit of acetolactate synthase 86 159 4.1E-28 T 09-03-2017 IPR019455 Acetolactate synthase, small subunit, C-terminal KEGG: 00290+2.2.1.6|KEGG: 00650+2.2.1.6|KEGG: 00660+2.2.1.6|KEGG: 00770+2.2.1.6|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-5938|MetaCyc: PWY-5939|MetaCyc: PWY-6389|MetaCyc: PWY-7111 TK78_RS08775 3916cdd42f3968ab8f0c757e1f94fee9 175 SUPERFAMILY SSF55021 4 76 1.13E-22 T 09-03-2017 TK78_RS08775 3916cdd42f3968ab8f0c757e1f94fee9 175 Pfam PF01842 ACT domain 5 70 7.0E-17 T 09-03-2017 IPR002912 ACT domain GO:0008152|GO:0016597 TK78_RS08775 3916cdd42f3968ab8f0c757e1f94fee9 175 ProDom PD002844 SMALL SUBUNIT ACETOLACTATE SYNTHASE SYNTHASE TRANSFERASE ACID BIOSYNTHESIS III LYASE 4 78 4.0E-35 T 09-03-2017 TK78_RS17340 27c7093518f0382ef51d569a37b236eb 171 Pfam PF01424 R3H domain 115 168 2.5E-16 T 09-03-2017 IPR001374 R3H domain GO:0003676 TK78_RS17340 27c7093518f0382ef51d569a37b236eb 171 SUPERFAMILY SSF82708 122 170 9.61E-12 T 09-03-2017 IPR001374 R3H domain GO:0003676 TK78_RS17340 27c7093518f0382ef51d569a37b236eb 171 Gene3D G3DSA:3.30.300.120 22 103 8.9E-22 T 09-03-2017 TK78_RS17340 27c7093518f0382ef51d569a37b236eb 171 SMART SM00393 93 171 9.6E-27 T 09-03-2017 IPR001374 R3H domain GO:0003676 TK78_RS17340 27c7093518f0382ef51d569a37b236eb 171 Gene3D G3DSA:3.30.1370.50 104 170 1.3E-23 T 09-03-2017 IPR001374 R3H domain GO:0003676 TK78_RS17340 27c7093518f0382ef51d569a37b236eb 171 Pfam PF13083 KH domain 28 98 2.1E-7 T 09-03-2017 TK78_RS07470 3a5c273df0b75053d43412473487707d 572 Gene3D G3DSA:3.50.50.60 274 354 5.1E-42 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS07470 3a5c273df0b75053d43412473487707d 572 Gene3D G3DSA:3.50.50.60 4 185 5.1E-42 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS07470 3a5c273df0b75053d43412473487707d 572 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 286 301 2.2E-29 T 09-03-2017 TK78_RS07470 3a5c273df0b75053d43412473487707d 572 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 301 317 2.2E-29 T 09-03-2017 TK78_RS07470 3a5c273df0b75053d43412473487707d 572 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 337 353 2.2E-29 T 09-03-2017 TK78_RS07470 3a5c273df0b75053d43412473487707d 572 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 319 337 2.2E-29 T 09-03-2017 TK78_RS07470 3a5c273df0b75053d43412473487707d 572 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 159 174 2.2E-29 T 09-03-2017 TK78_RS07470 3a5c273df0b75053d43412473487707d 572 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 3 25 2.2E-29 T 09-03-2017 TK78_RS07470 3a5c273df0b75053d43412473487707d 572 Pfam PF01494 FAD binding domain 3 349 6.1E-45 T 09-03-2017 IPR002938 FAD-binding domain GO:0071949 TK78_RS07470 3a5c273df0b75053d43412473487707d 572 SUPERFAMILY SSF51905 273 365 2.98E-44 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS07470 3a5c273df0b75053d43412473487707d 572 SUPERFAMILY SSF51905 3 180 2.98E-44 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS25315 6694ea2d915331e47da0f5c41651c188 266 Pfam PF09704 CRISPR-associated protein (Cas_Cas5) 10 234 1.2E-49 T 09-03-2017 IPR021124 CRISPR-associated protein, Cas5 GO:0043571 TK78_RS25315 6694ea2d915331e47da0f5c41651c188 266 TIGRFAM TIGR02593 CRISPR_cas5: CRISPR-associated protein Cas5 9 52 1.6E-10 T 09-03-2017 IPR013422 CRISPR-associated protein Cas5, N-terminal TK78_RS25315 6694ea2d915331e47da0f5c41651c188 266 TIGRFAM TIGR01868 casD_Cas5e: CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI 9 235 1.9E-46 T 09-03-2017 IPR010147 CRISPR-associated protein, CasD GO:0003723|GO:0051607 TK78_RS14275 774c3112de4719ece6bf0b714edc09ee 224 SUPERFAMILY SSF52540 16 188 5.92E-22 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS14275 774c3112de4719ece6bf0b714edc09ee 224 Pfam PF03029 Conserved hypothetical ATP binding protein 23 189 2.6E-23 T 09-03-2017 IPR004130 GPN-loop GTPase TK78_RS14275 774c3112de4719ece6bf0b714edc09ee 224 Gene3D G3DSA:3.40.50.300 12 188 1.5E-15 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29025 d93c3cf9fe98d60c6064ebcc86958757 243 Pfam PF12840 Helix-turn-helix domain 19 78 1.5E-9 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS29025 d93c3cf9fe98d60c6064ebcc86958757 243 SUPERFAMILY SSF46785 10 97 3.55E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS29025 d93c3cf9fe98d60c6064ebcc86958757 243 Gene3D G3DSA:1.10.10.10 5 98 6.5E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS29025 d93c3cf9fe98d60c6064ebcc86958757 243 SMART SM00418 19 98 1.3E-12 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS04320 aedf7fa55ea5dd092d2fcbc1adfce0ed 79 SUPERFAMILY SSF100950 2 60 1.51E-10 T 09-03-2017 TK78_RS04320 aedf7fa55ea5dd092d2fcbc1adfce0ed 79 Gene3D G3DSA:3.40.810.20 2 60 2.5E-13 T 09-03-2017 TK78_RS01990 d36077590cbfddae11ae93efe25b7023 134 SMART SM00889 5 123 0.0098 T 09-03-2017 IPR005517 Translation elongation factor EFG/EF2, domain IV GO:0005525 TK78_RS01990 d36077590cbfddae11ae93efe25b7023 134 Pfam PF03764 Elongation factor G, domain IV 15 122 6.4E-8 T 09-03-2017 IPR005517 Translation elongation factor EFG/EF2, domain IV GO:0005525 TK78_RS01990 d36077590cbfddae11ae93efe25b7023 134 Gene3D G3DSA:3.30.230.10 18 122 9.1E-12 T 09-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TK78_RS01990 d36077590cbfddae11ae93efe25b7023 134 SUPERFAMILY SSF54211 19 122 9.86E-7 T 09-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold TK78_RS12520 376fe710f4dfcf7cc0328868086a2049 393 Pfam PF00549 CoA-ligase 257 376 2.4E-13 T 09-03-2017 IPR005811 ATP-citrate lyase/succinyl-CoA ligase GO:0003824|GO:0008152 KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 TK78_RS12520 376fe710f4dfcf7cc0328868086a2049 393 PIRSF PIRSF001554 1 392 1.4E-134 T 09-03-2017 IPR005809 Succinyl-CoA synthetase, beta subunit GO:0003824|GO:0008152 KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384|Reactome: R-HSA-71403 TK78_RS12520 376fe710f4dfcf7cc0328868086a2049 393 Gene3D G3DSA:3.40.50.261 233 389 2.8E-52 T 09-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 TK78_RS12520 376fe710f4dfcf7cc0328868086a2049 393 Gene3D G3DSA:3.30.1490.20 22 85 5.4E-17 T 09-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 TK78_RS12520 376fe710f4dfcf7cc0328868086a2049 393 Gene3D G3DSA:3.30.470.20 86 229 2.3E-49 T 09-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 TK78_RS12520 376fe710f4dfcf7cc0328868086a2049 393 SUPERFAMILY SSF52210 232 389 6.02E-42 T 09-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 TK78_RS12520 376fe710f4dfcf7cc0328868086a2049 393 TIGRFAM TIGR01016 sucCoAbeta: succinate-CoA ligase, beta subunit 2 389 1.7E-123 T 09-03-2017 IPR005809 Succinyl-CoA synthetase, beta subunit GO:0003824|GO:0008152 KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384|Reactome: R-HSA-71403 TK78_RS12520 376fe710f4dfcf7cc0328868086a2049 393 Pfam PF08442 ATP-grasp domain 2 195 6.3E-67 T 09-03-2017 IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384|Reactome: R-HSA-71403 TK78_RS12520 376fe710f4dfcf7cc0328868086a2049 393 Hamap MF_00558 Succinyl-CoA ligase [ADP-forming] subunit beta [sucC]. 1 390 40.366 T 09-03-2017 IPR005809 Succinyl-CoA synthetase, beta subunit GO:0003824|GO:0008152 KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384|Reactome: R-HSA-71403 TK78_RS12520 376fe710f4dfcf7cc0328868086a2049 393 ProSitePatterns PS01217 ATP-citrate lyase / succinyl-CoA ligases family signature 3. 250 274 - T 09-03-2017 IPR017866 Succinyl-CoA synthetase, beta subunit, conserved site KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 TK78_RS12520 376fe710f4dfcf7cc0328868086a2049 393 SUPERFAMILY SSF56059 3 228 1.53E-62 T 09-03-2017 TK78_RS18645 b2b8dff3f50da97ddacb6e199dfdd8db 360 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 160 358 3.2E-25 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS18645 b2b8dff3f50da97ddacb6e199dfdd8db 360 Gene3D G3DSA:1.10.3720.10 85 354 4.0E-44 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS18645 b2b8dff3f50da97ddacb6e199dfdd8db 360 TIGRFAM TIGR00974 3a0107s02c: phosphate ABC transporter, permease protein PstA 87 352 5.6E-85 T 09-03-2017 IPR005672 Phosphate transport system permease protein PstA GO:0005315|GO:0005887|GO:0035435 TK78_RS18645 b2b8dff3f50da97ddacb6e199dfdd8db 360 SUPERFAMILY SSF161098 93 347 6.93E-41 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS23450 9e0a13c462a8f19b459770885a679083 186 Pfam PF15567 Immunity protein 35 5 94 3.8E-21 T 09-03-2017 IPR029082 Immunity protein 35 TK78_RS22350 ec6a1624c7698e4f9e6b214aea714862 480 Pfam PF00390 Malic enzyme, N-terminal domain 94 226 9.9E-31 T 09-03-2017 IPR012301 Malic enzyme, N-terminal domain GO:0004471|GO:0055114 TK78_RS22350 ec6a1624c7698e4f9e6b214aea714862 480 PRINTS PR00072 Malic enzyme signature 265 281 1.1E-11 T 09-03-2017 IPR001891 Malic oxidoreductase GO:0004470|GO:0004471|GO:0006108|GO:0055114 TK78_RS22350 ec6a1624c7698e4f9e6b214aea714862 480 PRINTS PR00072 Malic enzyme signature 234 250 1.1E-11 T 09-03-2017 IPR001891 Malic oxidoreductase GO:0004470|GO:0004471|GO:0006108|GO:0055114 TK78_RS22350 ec6a1624c7698e4f9e6b214aea714862 480 PRINTS PR00072 Malic enzyme signature 155 177 1.1E-11 T 09-03-2017 IPR001891 Malic oxidoreductase GO:0004470|GO:0004471|GO:0006108|GO:0055114 TK78_RS22350 ec6a1624c7698e4f9e6b214aea714862 480 PRINTS PR00072 Malic enzyme signature 358 374 1.1E-11 T 09-03-2017 IPR001891 Malic oxidoreductase GO:0004470|GO:0004471|GO:0006108|GO:0055114 TK78_RS22350 ec6a1624c7698e4f9e6b214aea714862 480 SMART SM01274 93 226 3.1E-85 T 09-03-2017 IPR012301 Malic enzyme, N-terminal domain GO:0004471|GO:0055114 TK78_RS22350 ec6a1624c7698e4f9e6b214aea714862 480 Gene3D G3DSA:3.40.50.720 236 464 7.9E-68 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS22350 ec6a1624c7698e4f9e6b214aea714862 480 SUPERFAMILY SSF51735 238 474 5.61E-66 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS22350 ec6a1624c7698e4f9e6b214aea714862 480 Pfam PF03949 Malic enzyme, NAD binding domain 240 461 4.4E-21 T 09-03-2017 IPR012302 Malic enzyme, NAD-binding GO:0004471|GO:0051287|GO:0055114 TK78_RS22350 ec6a1624c7698e4f9e6b214aea714862 480 Gene3D G3DSA:3.40.50.10380 93 235 1.9E-55 T 09-03-2017 IPR012301 Malic enzyme, N-terminal domain GO:0004471|GO:0055114 TK78_RS22350 ec6a1624c7698e4f9e6b214aea714862 480 SUPERFAMILY SSF53223 87 236 4.32E-57 T 09-03-2017 TK78_RS22350 ec6a1624c7698e4f9e6b214aea714862 480 SMART SM00919 238 465 1.2E-106 T 09-03-2017 IPR012302 Malic enzyme, NAD-binding GO:0004471|GO:0051287|GO:0055114 TK78_RS22350 ec6a1624c7698e4f9e6b214aea714862 480 PIRSF PIRSF000106 74 479 2.6E-81 T 09-03-2017 IPR001891 Malic oxidoreductase GO:0004470|GO:0004471|GO:0006108|GO:0055114 TK78_RS32275 23003bce0e1259e91d53e18e4c50b5f0 343 SUPERFAMILY SSF48613 162 318 8.67E-7 T 09-03-2017 IPR016084 Haem oxygenase-like, multi-helical Reactome: R-HSA-189483|Reactome: R-HSA-917937 TK78_RS32275 23003bce0e1259e91d53e18e4c50b5f0 343 SMART SM01236 175 280 1.5E-36 T 09-03-2017 TK78_RS32275 23003bce0e1259e91d53e18e4c50b5f0 343 Pfam PF14518 Iron-containing redox enzyme 143 315 6.3E-44 T 09-03-2017 IPR028201 PqqC-like protein TK78_RS32275 23003bce0e1259e91d53e18e4c50b5f0 343 Gene3D G3DSA:1.20.910.10 123 335 5.6E-57 T 09-03-2017 IPR016084 Haem oxygenase-like, multi-helical Reactome: R-HSA-189483|Reactome: R-HSA-917937 TK78_RS31855 ec513e4cfb83b59b28171e4357e69fe3 427 SUPERFAMILY SSF48452 281 398 2.32E-9 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS31855 ec513e4cfb83b59b28171e4357e69fe3 427 SUPERFAMILY SSF52129 2 187 3.56E-6 T 09-03-2017 IPR029030 Caspase-like domain TK78_RS31855 ec513e4cfb83b59b28171e4357e69fe3 427 Pfam PF13374 Tetratricopeptide repeat 327 368 0.0014 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS31855 ec513e4cfb83b59b28171e4357e69fe3 427 Pfam PF13374 Tetratricopeptide repeat 369 410 3.0E-5 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS31855 ec513e4cfb83b59b28171e4357e69fe3 427 Pfam PF00656 Caspase domain 1 170 2.4E-5 T 09-03-2017 TK78_RS31855 ec513e4cfb83b59b28171e4357e69fe3 427 Gene3D G3DSA:1.25.40.10 257 397 1.1E-5 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS31855 ec513e4cfb83b59b28171e4357e69fe3 427 Gene3D G3DSA:3.40.50.1460 1 137 1.9E-5 T 09-03-2017 IPR029030 Caspase-like domain TK78_RS13080 08f009eebca27b78a7d1f3fd8d9011b0 127 SUPERFAMILY SSF53137 14 125 5.89E-49 T 09-03-2017 TK78_RS13080 08f009eebca27b78a7d1f3fd8d9011b0 127 Gene3D G3DSA:3.30.420.100 32 127 7.2E-39 T 09-03-2017 TK78_RS13080 08f009eebca27b78a7d1f3fd8d9011b0 127 Pfam PF00861 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast 13 127 2.2E-50 T 09-03-2017 IPR005484 Ribosomal protein L18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13080 08f009eebca27b78a7d1f3fd8d9011b0 127 TIGRFAM TIGR00060 L18_bact: ribosomal protein uL18 14 127 1.7E-40 T 09-03-2017 IPR004389 Ribosomal protein L18, bacterial-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13080 08f009eebca27b78a7d1f3fd8d9011b0 127 Hamap MF_01337_B 50S ribosomal protein L18 [rplR]. 13 127 27.38 T 09-03-2017 IPR004389 Ribosomal protein L18, bacterial-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13925 09498fba440c5274814f3361a572a7ca 742 SUPERFAMILY SSF52210 190 335 6.54E-32 T 09-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 TK78_RS13925 09498fba440c5274814f3361a572a7ca 742 Gene3D G3DSA:3.30.470.20 533 574 1.1E-5 T 09-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 TK78_RS13925 09498fba440c5274814f3361a572a7ca 742 Gene3D G3DSA:3.40.50.720 53 177 4.2E-24 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS13925 09498fba440c5274814f3361a572a7ca 742 SUPERFAMILY SSF51735 54 182 1.29E-25 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS13925 09498fba440c5274814f3361a572a7ca 742 Pfam PF13380 CoA binding domain 61 182 1.7E-15 T 09-03-2017 IPR003781 CoA-binding GO:0048037 TK78_RS13925 09498fba440c5274814f3361a572a7ca 742 Pfam PF13607 Succinyl-CoA ligase like flavodoxin domain 199 333 1.8E-43 T 09-03-2017 IPR032875 Succinyl-CoA synthetase-like, flavodoxin domain TK78_RS13925 09498fba440c5274814f3361a572a7ca 742 SMART SM00881 57 152 4.3E-19 T 09-03-2017 IPR003781 CoA-binding GO:0048037 TK78_RS13925 09498fba440c5274814f3361a572a7ca 742 SUPERFAMILY SSF56059 529 740 5.89E-41 T 09-03-2017 TK78_RS13925 09498fba440c5274814f3361a572a7ca 742 SUPERFAMILY SSF52210 339 497 1.96E-25 T 09-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 TK78_RS13925 09498fba440c5274814f3361a572a7ca 742 Pfam PF13549 ATP-grasp domain 525 737 1.8E-61 T 09-03-2017 TK78_RS13925 09498fba440c5274814f3361a572a7ca 742 Gene3D G3DSA:3.40.50.261 178 331 2.5E-15 T 09-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 TK78_RS32930 b09e9c12ea74f61e93d54a0b5f215f43 503 ProSitePatterns PS00216 Sugar transport proteins signature 1. 327 344 - T 09-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 TK78_RS32930 b09e9c12ea74f61e93d54a0b5f215f43 503 ProSitePatterns PS00217 Sugar transport proteins signature 2. 139 164 - T 09-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 TK78_RS32930 b09e9c12ea74f61e93d54a0b5f215f43 503 Pfam PF00083 Sugar (and other) transporter 30 460 2.9E-51 T 09-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 TK78_RS32930 b09e9c12ea74f61e93d54a0b5f215f43 503 Gene3D G3DSA:1.20.1250.20 25 234 8.0E-29 T 09-03-2017 TK78_RS32930 b09e9c12ea74f61e93d54a0b5f215f43 503 Gene3D G3DSA:1.20.1250.20 271 456 3.9E-22 T 09-03-2017 TK78_RS32930 b09e9c12ea74f61e93d54a0b5f215f43 503 SUPERFAMILY SSF103473 19 459 6.02E-73 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS29175 1858373e3465990f01ce616de2b961c0 312 ProSitePatterns PS01129 Rlu family of pseudouridine synthase signature. 145 159 - T 09-03-2017 IPR006224 Pseudouridine synthase, RluC/RluD, conserved site GO:0001522|GO:0003723|GO:0009451|GO:0009982 TK78_RS29175 1858373e3465990f01ce616de2b961c0 312 Pfam PF00849 RNA pseudouridylate synthase 107 253 3.8E-18 T 09-03-2017 IPR006145 Pseudouridine synthase, RsuA/RluB/C/D/E/F GO:0001522|GO:0003723|GO:0009451|GO:0009982 TK78_RS29175 1858373e3465990f01ce616de2b961c0 312 SUPERFAMILY SSF55120 92 304 3.04E-47 T 09-03-2017 IPR020103 Pseudouridine synthase, catalytic domain GO:0001522|GO:0003723|GO:0009451|GO:0009982 TK78_RS05065 465772f6caac05a9aea141cd51b39959 594 SUPERFAMILY SSF52467 157 359 4.24E-46 T 09-03-2017 IPR029035 DHS-like NAD/FAD-binding domain TK78_RS05065 465772f6caac05a9aea141cd51b39959 594 Gene3D G3DSA:3.40.50.970 362 564 9.9E-59 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS05065 465772f6caac05a9aea141cd51b39959 594 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 393 552 6.4E-33 T 09-03-2017 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 TK78_RS05065 465772f6caac05a9aea141cd51b39959 594 SUPERFAMILY SSF52518 369 563 5.18E-50 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS05065 465772f6caac05a9aea141cd51b39959 594 Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain 4 172 5.3E-50 T 09-03-2017 IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain GO:0030976 TK78_RS05065 465772f6caac05a9aea141cd51b39959 594 SUPERFAMILY SSF52518 1 184 1.22E-48 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS05065 465772f6caac05a9aea141cd51b39959 594 Gene3D G3DSA:3.40.50.1220 186 361 4.8E-49 T 09-03-2017 IPR029035 DHS-like NAD/FAD-binding domain TK78_RS05065 465772f6caac05a9aea141cd51b39959 594 Pfam PF00205 Thiamine pyrophosphate enzyme, central domain 193 327 3.6E-34 T 09-03-2017 IPR012000 Thiamine pyrophosphate enzyme, central domain GO:0000287|GO:0030976 TK78_RS05065 465772f6caac05a9aea141cd51b39959 594 TIGRFAM TIGR01504 glyox_carbo_lig: glyoxylate carboligase 3 589 0.0 T 09-03-2017 IPR006397 Glyoxylate carboligase GO:0009028|GO:0009436 KEGG: 00630+4.1.1.47 TK78_RS05065 465772f6caac05a9aea141cd51b39959 594 Gene3D G3DSA:3.40.50.970 3 182 1.1E-59 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS32040 176ea934ef9542689d2cbe5c7a8abfca 409 SUPERFAMILY SSF51197 21 304 1.65E-49 T 09-03-2017 TK78_RS32040 176ea934ef9542689d2cbe5c7a8abfca 409 SMART SM00558 71 258 0.0014 T 09-03-2017 IPR003347 JmjC domain TK78_RS32040 176ea934ef9542689d2cbe5c7a8abfca 409 Gene3D G3DSA:2.60.120.650 22 246 3.5E-40 T 09-03-2017 TK78_RS32040 176ea934ef9542689d2cbe5c7a8abfca 409 Pfam PF08007 Cupin superfamily protein 30 278 4.0E-39 T 09-03-2017 IPR003347 JmjC domain TK78_RS14285 d0766329c0c32f1ebcec42b672157838 410 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 343 352 - T 09-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 TK78_RS14285 d0766329c0c32f1ebcec42b672157838 410 Gene3D G3DSA:1.10.630.10 8 401 1.5E-113 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS14285 d0766329c0c32f1ebcec42b672157838 410 SUPERFAMILY SSF48264 8 400 4.98E-87 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS14285 d0766329c0c32f1ebcec42b672157838 410 PRINTS PR00359 B-class P450 signature 138 154 1.5E-37 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS14285 d0766329c0c32f1ebcec42b672157838 410 PRINTS PR00359 B-class P450 signature 192 214 1.5E-37 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS14285 d0766329c0c32f1ebcec42b672157838 410 PRINTS PR00359 B-class P450 signature 273 284 1.5E-37 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS14285 d0766329c0c32f1ebcec42b672157838 410 PRINTS PR00359 B-class P450 signature 155 170 1.5E-37 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS14285 d0766329c0c32f1ebcec42b672157838 410 PRINTS PR00359 B-class P450 signature 341 350 1.5E-37 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS14285 d0766329c0c32f1ebcec42b672157838 410 PRINTS PR00359 B-class P450 signature 291 318 1.5E-37 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS14285 d0766329c0c32f1ebcec42b672157838 410 PRINTS PR00359 B-class P450 signature 350 361 1.5E-37 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS14285 d0766329c0c32f1ebcec42b672157838 410 PRINTS PR00359 B-class P450 signature 89 100 1.5E-37 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS14285 d0766329c0c32f1ebcec42b672157838 410 Pfam PF00067 Cytochrome P450 83 264 3.7E-7 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS14285 d0766329c0c32f1ebcec42b672157838 410 Pfam PF00067 Cytochrome P450 273 371 4.5E-15 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS16765 8a36d6959c8612feecda36d603e9c5c0 187 SUPERFAMILY SSF88659 117 179 4.86E-16 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16765 8a36d6959c8612feecda36d603e9c5c0 187 TIGRFAM TIGR02983 SigE-fam_strep: RNA polymerase sigma-70 factor, sigma-E family 26 183 3.1E-63 T 09-03-2017 IPR014325 RNA polymerase sigma-E factor, actinobacteria GO:0016987 TK78_RS16765 8a36d6959c8612feecda36d603e9c5c0 187 SUPERFAMILY SSF88946 27 116 1.29E-12 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16765 8a36d6959c8612feecda36d603e9c5c0 187 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 36 179 8.6E-23 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16765 8a36d6959c8612feecda36d603e9c5c0 187 Pfam PF04542 Sigma-70 region 2 33 97 3.6E-8 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16765 8a36d6959c8612feecda36d603e9c5c0 187 Gene3D G3DSA:1.10.10.10 119 179 4.9E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS16765 8a36d6959c8612feecda36d603e9c5c0 187 Pfam PF08281 Sigma-70, region 4 125 177 2.0E-17 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16765 8a36d6959c8612feecda36d603e9c5c0 187 Gene3D G3DSA:1.10.1740.10 26 98 5.2E-13 T 09-03-2017 TK78_RS13115 1750ee2db40742e32f2a38964e7f7127 122 SMART SM01374 1 122 9.2E-85 T 09-03-2017 IPR000218 Ribosomal protein L14P GO:0003735|GO:0005840|GO:0006412 TK78_RS13115 1750ee2db40742e32f2a38964e7f7127 122 SUPERFAMILY SSF50193 2 122 5.49E-49 T 09-03-2017 IPR000218 Ribosomal protein L14P GO:0003735|GO:0005840|GO:0006412 TK78_RS13115 1750ee2db40742e32f2a38964e7f7127 122 Pfam PF00238 Ribosomal protein L14p/L23e 2 122 2.5E-52 T 09-03-2017 IPR000218 Ribosomal protein L14P GO:0003735|GO:0005840|GO:0006412 TK78_RS13115 1750ee2db40742e32f2a38964e7f7127 122 ProSitePatterns PS00049 Ribosomal protein L14 signature. 60 86 - T 09-03-2017 IPR019972 Ribosomal protein L14P, conserved site Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13115 1750ee2db40742e32f2a38964e7f7127 122 Gene3D G3DSA:2.40.150.20 2 122 7.6E-52 T 09-03-2017 IPR000218 Ribosomal protein L14P GO:0003735|GO:0005840|GO:0006412 TK78_RS13115 1750ee2db40742e32f2a38964e7f7127 122 TIGRFAM TIGR01067 rplN_bact: ribosomal protein uL14 1 122 5.4E-56 T 09-03-2017 IPR005745 Ribosomal protein L14P, bacterial-type GO:0003735|GO:0006412|GO:0015934 TK78_RS13115 1750ee2db40742e32f2a38964e7f7127 122 Hamap MF_01367 50S ribosomal protein L14 [rplN]. 1 122 26.473 T 09-03-2017 IPR000218 Ribosomal protein L14P GO:0003735|GO:0005840|GO:0006412 TK78_RS13475 135895ffea1d22ea48e50b92f52dc16c 129 Gene3D G3DSA:3.30.530.20 7 128 2.7E-13 T 09-03-2017 IPR023393 START-like domain TK78_RS13475 135895ffea1d22ea48e50b92f52dc16c 129 SUPERFAMILY SSF55961 3 128 3.47E-16 T 09-03-2017 TK78_RS00425 64f1b4b05eaff01a45dd2af2dfa15d39 344 Gene3D G3DSA:3.40.50.2300 25 146 2.1E-31 T 09-03-2017 TK78_RS00425 64f1b4b05eaff01a45dd2af2dfa15d39 344 Gene3D G3DSA:3.40.50.2300 147 316 2.8E-33 T 09-03-2017 TK78_RS00425 64f1b4b05eaff01a45dd2af2dfa15d39 344 Pfam PF13407 Periplasmic binding protein domain 28 288 8.6E-54 T 09-03-2017 IPR025997 Periplasmic binding protein TK78_RS00425 64f1b4b05eaff01a45dd2af2dfa15d39 344 SUPERFAMILY SSF53822 24 316 7.46E-62 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS08650 abbe5138d0f63dffb0cd96a33b11eaa3 326 SUPERFAMILY SSF161098 95 323 6.98E-16 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS08650 abbe5138d0f63dffb0cd96a33b11eaa3 326 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 118 324 8.2E-41 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS08650 abbe5138d0f63dffb0cd96a33b11eaa3 326 Gene3D G3DSA:1.10.3720.10 94 320 2.2E-15 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS03770 14ed28ce141504a15e5a72cdda1c88bc 211 SUPERFAMILY SSF63817 65 210 6.02E-18 T 09-03-2017 IPR023365 Sortase domain TK78_RS03770 14ed28ce141504a15e5a72cdda1c88bc 211 Pfam PF04203 Sortase family 71 211 5.7E-17 T 09-03-2017 IPR005754 Sortase family TK78_RS03770 14ed28ce141504a15e5a72cdda1c88bc 211 Gene3D G3DSA:2.40.260.10 65 209 2.5E-10 T 09-03-2017 IPR023365 Sortase domain TK78_RS14965 d69625d5da09a72409bd1c3693366f9a 629 Gene3D G3DSA:1.20.1560.10 61 367 1.8E-64 T 09-03-2017 TK78_RS14965 d69625d5da09a72409bd1c3693366f9a 629 Pfam PF00005 ABC transporter 407 554 6.8E-31 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS14965 d69625d5da09a72409bd1c3693366f9a 629 Pfam PF00664 ABC transporter transmembrane region 75 339 3.2E-39 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS14965 d69625d5da09a72409bd1c3693366f9a 629 Gene3D G3DSA:3.40.50.300 388 618 1.2E-74 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS14965 d69625d5da09a72409bd1c3693366f9a 629 SUPERFAMILY SSF90123 59 369 6.15E-62 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS14965 d69625d5da09a72409bd1c3693366f9a 629 SMART SM00382 414 600 3.0E-14 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS14965 d69625d5da09a72409bd1c3693366f9a 629 SUPERFAMILY SSF52540 387 624 3.0E-80 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS14965 d69625d5da09a72409bd1c3693366f9a 629 ProSitePatterns PS00211 ABC transporters family signature. 526 540 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS12645 d84712d2b9028b5f5cfd9a0931bba36f 528 SUPERFAMILY SSF52317 15 207 4.13E-52 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS12645 d84712d2b9028b5f5cfd9a0931bba36f 528 TIGRFAM TIGR00888 guaA_Nterm: GMP synthase (glutamine-hydrolyzing), N-terminal domain 16 198 1.8E-71 T 09-03-2017 IPR004739 GMP synthase, N-terminal GO:0003922|GO:0005524|GO:0006177 KEGG: 00230+6.3.5.2|KEGG: 00983+6.3.5.2|MetaCyc: PWY-7221|Reactome: R-HSA-73817 TK78_RS12645 d84712d2b9028b5f5cfd9a0931bba36f 528 Hamap MF_00344 GMP synthase [glutamine-hydrolyzing] [guaA]. 13 528 53.325 T 09-03-2017 IPR022955 GMP synthase GO:0003922|GO:0006177 KEGG: 00230+6.3.5.2|KEGG: 00983+6.3.5.2|MetaCyc: PWY-7221 TK78_RS12645 d84712d2b9028b5f5cfd9a0931bba36f 528 PRINTS PR00096 Glutamine amidotransferase superfamily signature 60 69 9.8E-8 T 09-03-2017 TK78_RS12645 d84712d2b9028b5f5cfd9a0931bba36f 528 PRINTS PR00096 Glutamine amidotransferase superfamily signature 176 189 9.8E-8 T 09-03-2017 TK78_RS12645 d84712d2b9028b5f5cfd9a0931bba36f 528 PRINTS PR00096 Glutamine amidotransferase superfamily signature 87 98 9.8E-8 T 09-03-2017 TK78_RS12645 d84712d2b9028b5f5cfd9a0931bba36f 528 Gene3D G3DSA:3.40.50.620 222 402 1.6E-56 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS12645 d84712d2b9028b5f5cfd9a0931bba36f 528 TIGRFAM TIGR00884 guaA_Cterm: GMP synthase (glutamine-hydrolyzing), C-terminal domain 211 528 1.7E-145 T 09-03-2017 IPR001674 GMP synthase, C-terminal GO:0003922|GO:0005524|GO:0006164|GO:0006177 KEGG: 00230+6.3.5.2|KEGG: 00983+6.3.5.2|MetaCyc: PWY-7221|Reactome: R-HSA-73817 TK78_RS12645 d84712d2b9028b5f5cfd9a0931bba36f 528 Pfam PF02540 NAD synthase 220 287 9.6E-7 T 09-03-2017 IPR022310 NAD/GMP synthase TK78_RS12645 d84712d2b9028b5f5cfd9a0931bba36f 528 SUPERFAMILY SSF54810 407 528 3.27E-46 T 09-03-2017 TK78_RS12645 d84712d2b9028b5f5cfd9a0931bba36f 528 Pfam PF00958 GMP synthase C terminal domain 435 527 3.3E-38 T 09-03-2017 IPR001674 GMP synthase, C-terminal GO:0003922|GO:0005524|GO:0006164|GO:0006177 KEGG: 00230+6.3.5.2|KEGG: 00983+6.3.5.2|MetaCyc: PWY-7221|Reactome: R-HSA-73817 TK78_RS12645 d84712d2b9028b5f5cfd9a0931bba36f 528 Gene3D G3DSA:3.40.50.880 10 221 3.0E-58 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS12645 d84712d2b9028b5f5cfd9a0931bba36f 528 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 57 71 7.9E-6 T 09-03-2017 TK78_RS12645 d84712d2b9028b5f5cfd9a0931bba36f 528 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 16 30 7.9E-6 T 09-03-2017 TK78_RS12645 d84712d2b9028b5f5cfd9a0931bba36f 528 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 87 103 7.9E-6 T 09-03-2017 TK78_RS12645 d84712d2b9028b5f5cfd9a0931bba36f 528 Gene3D G3DSA:3.30.300.10 403 528 2.4E-48 T 09-03-2017 TK78_RS12645 d84712d2b9028b5f5cfd9a0931bba36f 528 SUPERFAMILY SSF52402 192 448 1.52E-57 T 09-03-2017 TK78_RS12645 d84712d2b9028b5f5cfd9a0931bba36f 528 PRINTS PR00097 Anthranilate synthase component II signature 60 69 8.3E-6 T 09-03-2017 TK78_RS12645 d84712d2b9028b5f5cfd9a0931bba36f 528 PRINTS PR00097 Anthranilate synthase component II signature 87 98 8.3E-6 T 09-03-2017 TK78_RS12645 d84712d2b9028b5f5cfd9a0931bba36f 528 PRINTS PR00097 Anthranilate synthase component II signature 176 189 8.3E-6 T 09-03-2017 TK78_RS12645 d84712d2b9028b5f5cfd9a0931bba36f 528 Pfam PF00117 Glutamine amidotransferase class-I 18 198 2.2E-40 T 09-03-2017 IPR017926 Glutamine amidotransferase TK78_RS21695 e76969bd734b7b15b2e614101103c0a2 281 SUPERFAMILY SSF46689 17 77 7.53E-14 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS21695 e76969bd734b7b15b2e614101103c0a2 281 Pfam PF01418 Helix-turn-helix domain, rpiR family 16 76 1.7E-11 T 09-03-2017 IPR000281 Helix-turn-helix protein RpiR GO:0003700|GO:0006355 TK78_RS21695 e76969bd734b7b15b2e614101103c0a2 281 Gene3D G3DSA:1.10.10.10 17 77 1.0E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS21695 e76969bd734b7b15b2e614101103c0a2 281 SUPERFAMILY SSF53697 91 264 1.31E-5 T 09-03-2017 TK78_RS07565 23d32859611b096a807da578854cad7f 156 PIRSF PIRSF005900 1 156 1.1E-42 T 09-03-2017 IPR002177 DNA-binding protein Dps GO:0006950|GO:0055114 TK78_RS07565 23d32859611b096a807da578854cad7f 156 PRINTS PR01346 Helicobacter neutrophil-activating protein A family signature 133 151 1.6E-12 T 09-03-2017 IPR002177 DNA-binding protein Dps GO:0006950|GO:0055114 TK78_RS07565 23d32859611b096a807da578854cad7f 156 PRINTS PR01346 Helicobacter neutrophil-activating protein A family signature 38 54 1.6E-12 T 09-03-2017 IPR002177 DNA-binding protein Dps GO:0006950|GO:0055114 TK78_RS07565 23d32859611b096a807da578854cad7f 156 PRINTS PR01346 Helicobacter neutrophil-activating protein A family signature 62 78 1.6E-12 T 09-03-2017 IPR002177 DNA-binding protein Dps GO:0006950|GO:0055114 TK78_RS07565 23d32859611b096a807da578854cad7f 156 ProSitePatterns PS00818 Dps protein family signature 1. 38 54 - T 09-03-2017 IPR023188 DNA-binding protein Dps, conserved site GO:0016722|GO:0055114 TK78_RS07565 23d32859611b096a807da578854cad7f 156 SUPERFAMILY SSF47240 4 153 1.24E-46 T 09-03-2017 IPR009078 Ferritin-like superfamily TK78_RS07565 23d32859611b096a807da578854cad7f 156 Gene3D G3DSA:1.20.1260.10 2 153 5.0E-46 T 09-03-2017 IPR012347 Ferritin-related TK78_RS07565 23d32859611b096a807da578854cad7f 156 Pfam PF00210 Ferritin-like domain 19 153 9.9E-22 T 09-03-2017 IPR008331 Ferritin/DPS protein domain GO:0006879|GO:0008199 TK78_RS01895 28d3afe19b5d88313ba67c35f6dcd608 1101 Gene3D G3DSA:3.40.47.10 10 275 2.4E-66 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS01895 28d3afe19b5d88313ba67c35f6dcd608 1101 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 271 389 6.5E-34 T 09-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal TK78_RS01895 28d3afe19b5d88313ba67c35f6dcd608 1101 Gene3D G3DSA:3.40.47.10 276 443 6.9E-52 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS01895 28d3afe19b5d88313ba67c35f6dcd608 1101 Pfam PF00698 Acyl transferase domain 546 831 8.4E-49 T 09-03-2017 IPR014043 Acyl transferase TK78_RS01895 28d3afe19b5d88313ba67c35f6dcd608 1101 SUPERFAMILY SSF52151 738 834 9.68E-63 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS01895 28d3afe19b5d88313ba67c35f6dcd608 1101 SUPERFAMILY SSF52151 544 675 9.68E-63 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS01895 28d3afe19b5d88313ba67c35f6dcd608 1101 SMART SM00823 Phosphopantetheine attachment site 920 992 7.1E-4 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS01895 28d3afe19b5d88313ba67c35f6dcd608 1101 Gene3D G3DSA:3.40.366.10 542 669 1.3E-63 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS01895 28d3afe19b5d88313ba67c35f6dcd608 1101 Gene3D G3DSA:3.40.366.10 736 843 1.3E-63 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS01895 28d3afe19b5d88313ba67c35f6dcd608 1101 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 9 263 1.1E-57 T 09-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal TK78_RS01895 28d3afe19b5d88313ba67c35f6dcd608 1101 SUPERFAMILY SSF55048 674 737 4.32E-8 T 09-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 TK78_RS01895 28d3afe19b5d88313ba67c35f6dcd608 1101 SUPERFAMILY SSF47336 916 1017 4.45E-15 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01895 28d3afe19b5d88313ba67c35f6dcd608 1101 SMART SM00825 Beta-ketoacyl synthase 10 442 1.9E-140 T 09-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TK78_RS01895 28d3afe19b5d88313ba67c35f6dcd608 1101 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 176 192 - T 09-03-2017 IPR018201 Beta-ketoacyl synthase, active site TK78_RS01895 28d3afe19b5d88313ba67c35f6dcd608 1101 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 549 843 5.6E-79 T 09-03-2017 IPR020801 Polyketide synthase, acyl transferase domain TK78_RS01895 28d3afe19b5d88313ba67c35f6dcd608 1101 Pfam PF00550 Phosphopantetheine attachment site 923 988 1.1E-12 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01895 28d3afe19b5d88313ba67c35f6dcd608 1101 Gene3D G3DSA:1.10.1200.10 919 992 1.3E-12 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS01895 28d3afe19b5d88313ba67c35f6dcd608 1101 ProSitePatterns PS00012 Phosphopantetheine attachment site. 946 961 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS01895 28d3afe19b5d88313ba67c35f6dcd608 1101 SUPERFAMILY SSF53901 417 438 5.31E-75 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS01895 28d3afe19b5d88313ba67c35f6dcd608 1101 SUPERFAMILY SSF53901 6 124 5.31E-75 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS01895 28d3afe19b5d88313ba67c35f6dcd608 1101 SUPERFAMILY SSF53901 159 385 5.31E-75 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS01895 28d3afe19b5d88313ba67c35f6dcd608 1101 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 392 497 6.2E-16 T 09-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS11165 ccd89d250fcd390d2f27bdd81fbe932e 259 Pfam PF08291 Peptidase M15 131 244 3.7E-34 T 09-03-2017 IPR013230 Peptidase M15A, C-terminal MetaCyc: PWY-6470 TK78_RS11165 ccd89d250fcd390d2f27bdd81fbe932e 259 SUPERFAMILY SSF55166 130 257 7.06E-26 T 09-03-2017 IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain Reactome: R-HSA-373080|Reactome: R-HSA-5358346|Reactome: R-HSA-5362798|Reactome: R-HSA-5632681|Reactome: R-HSA-5658034 TK78_RS11165 ccd89d250fcd390d2f27bdd81fbe932e 259 Pfam PF01471 Putative peptidoglycan binding domain 61 118 6.2E-15 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS11165 ccd89d250fcd390d2f27bdd81fbe932e 259 Gene3D G3DSA:3.30.1380.10 131 254 7.3E-31 T 09-03-2017 IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain Reactome: R-HSA-373080|Reactome: R-HSA-5358346|Reactome: R-HSA-5362798|Reactome: R-HSA-5632681|Reactome: R-HSA-5658034 TK78_RS11165 ccd89d250fcd390d2f27bdd81fbe932e 259 SUPERFAMILY SSF47090 49 122 1.39E-19 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS11165 ccd89d250fcd390d2f27bdd81fbe932e 259 Gene3D G3DSA:1.10.101.10 53 122 2.3E-22 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS28050 5b7ef0b3904822d0b941339a75528c84 293 ProSitePatterns PS00666 Dihydrodipicolinate synthase signature 2. 140 170 - T 09-03-2017 IPR020625 Schiff base-forming aldolase, active site GO:0008152|GO:0016829 KEGG: 00261+4.3.3.7|KEGG: 00300+4.3.3.7|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS28050 5b7ef0b3904822d0b941339a75528c84 293 Gene3D G3DSA:3.20.20.70 8 290 4.5E-88 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS28050 5b7ef0b3904822d0b941339a75528c84 293 ProSitePatterns PS00665 Dihydrodipicolinate synthase signature 1. 45 62 - T 09-03-2017 IPR020624 Schiff base-forming aldolase, conserved site GO:0008152|GO:0016829 KEGG: 00261+4.3.3.7|KEGG: 00300+4.3.3.7|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS28050 5b7ef0b3904822d0b941339a75528c84 293 TIGRFAM TIGR00674 dapA: 4-hydroxy-tetrahydrodipicolinate synthase 13 286 2.9E-63 T 09-03-2017 IPR005263 4-hydroxy-tetrahydrodipicolinate synthase, DapA GO:0008840|GO:0009089 KEGG: 00261+4.3.3.7|KEGG: 00300+4.3.3.7|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS28050 5b7ef0b3904822d0b941339a75528c84 293 Pfam PF00701 Dihydrodipicolinate synthetase family 9 286 6.6E-67 T 09-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 TK78_RS28050 5b7ef0b3904822d0b941339a75528c84 293 PIRSF PIRSF001365 5 293 5.4E-73 T 09-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 TK78_RS28050 5b7ef0b3904822d0b941339a75528c84 293 SMART SM01130 8 291 2.1E-93 T 09-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 TK78_RS28050 5b7ef0b3904822d0b941339a75528c84 293 SUPERFAMILY SSF51569 7 290 1.36E-80 T 09-03-2017 TK78_RS28050 5b7ef0b3904822d0b941339a75528c84 293 PRINTS PR00146 Dihydrodipicolinate synthase signature 42 63 6.8E-25 T 09-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 TK78_RS28050 5b7ef0b3904822d0b941339a75528c84 293 PRINTS PR00146 Dihydrodipicolinate synthase signature 135 152 6.8E-25 T 09-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 TK78_RS28050 5b7ef0b3904822d0b941339a75528c84 293 PRINTS PR00146 Dihydrodipicolinate synthase signature 78 96 6.8E-25 T 09-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 TK78_RS28050 5b7ef0b3904822d0b941339a75528c84 293 PRINTS PR00146 Dihydrodipicolinate synthase signature 110 126 6.8E-25 T 09-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 TK78_RS28050 5b7ef0b3904822d0b941339a75528c84 293 Hamap MF_00418 4-hydroxy-tetrahydrodipicolinate synthase [dapA]. 8 289 45.707 T 09-03-2017 IPR005263 4-hydroxy-tetrahydrodipicolinate synthase, DapA GO:0008840|GO:0009089 KEGG: 00261+4.3.3.7|KEGG: 00300+4.3.3.7|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS12025 76561a35a80277f072d7e1651ece898b 479 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 318 325 4.9E-53 T 09-03-2017 TK78_RS12025 76561a35a80277f072d7e1651ece898b 479 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 419 434 4.9E-53 T 09-03-2017 TK78_RS12025 76561a35a80277f072d7e1651ece898b 479 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 275 289 4.9E-53 T 09-03-2017 TK78_RS12025 76561a35a80277f072d7e1651ece898b 479 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 35 50 4.9E-53 T 09-03-2017 TK78_RS12025 76561a35a80277f072d7e1651ece898b 479 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 154 163 4.9E-53 T 09-03-2017 TK78_RS12025 76561a35a80277f072d7e1651ece898b 479 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 3 25 4.9E-53 T 09-03-2017 TK78_RS12025 76561a35a80277f072d7e1651ece898b 479 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 190 215 4.9E-53 T 09-03-2017 TK78_RS12025 76561a35a80277f072d7e1651ece898b 479 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 441 461 4.9E-53 T 09-03-2017 TK78_RS12025 76561a35a80277f072d7e1651ece898b 479 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 354 375 4.9E-53 T 09-03-2017 TK78_RS12025 76561a35a80277f072d7e1651ece898b 479 SUPERFAMILY SSF55424 354 472 2.06E-29 T 09-03-2017 IPR016156 FAD/NAD-linked reductase, dimerisation domain GO:0016491|GO:0050660|GO:0055114 TK78_RS12025 76561a35a80277f072d7e1651ece898b 479 Gene3D G3DSA:3.50.50.60 3 154 7.8E-27 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS12025 76561a35a80277f072d7e1651ece898b 479 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 151 169 3.7E-34 T 09-03-2017 TK78_RS12025 76561a35a80277f072d7e1651ece898b 479 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 4 23 3.7E-34 T 09-03-2017 TK78_RS12025 76561a35a80277f072d7e1651ece898b 479 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 274 290 3.7E-34 T 09-03-2017 TK78_RS12025 76561a35a80277f072d7e1651ece898b 479 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 190 208 3.7E-34 T 09-03-2017 TK78_RS12025 76561a35a80277f072d7e1651ece898b 479 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 303 325 3.7E-34 T 09-03-2017 TK78_RS12025 76561a35a80277f072d7e1651ece898b 479 Pfam PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 360 465 4.0E-25 T 09-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 TK78_RS12025 76561a35a80277f072d7e1651ece898b 479 Gene3D G3DSA:3.30.390.30 352 471 1.4E-32 T 09-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 TK78_RS12025 76561a35a80277f072d7e1651ece898b 479 Gene3D G3DSA:3.50.50.60 155 346 5.2E-47 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS12025 76561a35a80277f072d7e1651ece898b 479 PIRSF PIRSF000350 1 472 1.5E-74 T 09-03-2017 TK78_RS12025 76561a35a80277f072d7e1651ece898b 479 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 3 338 6.2E-56 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS12025 76561a35a80277f072d7e1651ece898b 479 SUPERFAMILY SSF51905 3 347 3.56E-46 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS08300 f1045ed8967f1f725992ead2c44eba57 577 SMART SM01120 38 206 9.0E-44 T 09-03-2017 IPR004007 DhaL domain GO:0004371|GO:0006071 Reactome: R-HSA-168928|Reactome: R-HSA-70350 TK78_RS08300 f1045ed8967f1f725992ead2c44eba57 577 TIGRFAM TIGR03599 YloV: DAK2 domain fusion protein YloV 14 577 1.5E-131 T 09-03-2017 IPR019986 DAK2 domain-containing protein YloV TK78_RS08300 f1045ed8967f1f725992ead2c44eba57 577 SMART SM01121 274 577 1.0E-98 T 09-03-2017 IPR033470 Uncharacterised protein, DhaK domain TK78_RS08300 f1045ed8967f1f725992ead2c44eba57 577 Pfam PF13684 Dihydroxyacetone kinase family 276 577 1.4E-80 T 09-03-2017 IPR033470 Uncharacterised protein, DhaK domain TK78_RS08300 f1045ed8967f1f725992ead2c44eba57 577 SUPERFAMILY SSF101473 9 207 5.89E-31 T 09-03-2017 IPR004007 DhaL domain GO:0004371|GO:0006071 Reactome: R-HSA-168928|Reactome: R-HSA-70350 TK78_RS08300 f1045ed8967f1f725992ead2c44eba57 577 Pfam PF02734 DAK2 domain 38 205 7.0E-28 T 09-03-2017 IPR004007 DhaL domain GO:0004371|GO:0006071 Reactome: R-HSA-168928|Reactome: R-HSA-70350 TK78_RS17250 ac124b44f1b112647c93622d801f5c09 500 Pfam PF09594 Protein of unknown function (DUF2029) 123 365 3.4E-13 T 09-03-2017 IPR018584 Glycosyltransferase family 87 GO:0016758 TK78_RS17250 ac124b44f1b112647c93622d801f5c09 500 PIRSF PIRSF010361 18 470 1.1E-145 T 09-03-2017 IPR016570 Uncharacterised conserved protein UCP010361, membrane TK78_RS28845 8e197b413ac60ae19dd316af74d493cd 299 Gene3D G3DSA:2.40.10.10 198 286 1.1E-30 T 09-03-2017 TK78_RS28845 8e197b413ac60ae19dd316af74d493cd 299 Pfam PF02983 Alpha-lytic protease prodomain 44 98 2.3E-11 T 09-03-2017 IPR004236 Peptidase S1A, alpha-lytic prodomain GO:0005576|GO:0006508|GO:0008236 TK78_RS28845 8e197b413ac60ae19dd316af74d493cd 299 Gene3D G3DSA:2.40.10.10 115 197 3.1E-30 T 09-03-2017 TK78_RS28845 8e197b413ac60ae19dd316af74d493cd 299 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 220 237 1.9E-48 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS28845 8e197b413ac60ae19dd316af74d493cd 299 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 240 263 1.9E-48 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS28845 8e197b413ac60ae19dd316af74d493cd 299 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 264 278 1.9E-48 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS28845 8e197b413ac60ae19dd316af74d493cd 299 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 199 219 1.9E-48 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS28845 8e197b413ac60ae19dd316af74d493cd 299 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 141 155 1.9E-48 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS28845 8e197b413ac60ae19dd316af74d493cd 299 ProSitePatterns PS00134 Serine proteases, trypsin family, histidine active site. 143 148 - T 09-03-2017 IPR018114 Serine proteases, trypsin family, histidine active site GO:0004252|GO:0006508 TK78_RS28845 8e197b413ac60ae19dd316af74d493cd 299 Pfam PF00089 Trypsin 138 289 5.0E-7 T 09-03-2017 IPR001254 Serine proteases, trypsin domain GO:0004252|GO:0006508 TK78_RS28845 8e197b413ac60ae19dd316af74d493cd 299 SUPERFAMILY SSF50494 122 292 1.41E-36 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS28845 8e197b413ac60ae19dd316af74d493cd 299 Gene3D G3DSA:3.30.300.50 59 110 2.5E-8 T 09-03-2017 TK78_RS28845 8e197b413ac60ae19dd316af74d493cd 299 PIRSF PIRSF001134 3 299 4.6E-97 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS28845 8e197b413ac60ae19dd316af74d493cd 299 ProSitePatterns PS00135 Serine proteases, trypsin family, serine active site. 249 260 - T 09-03-2017 IPR033116 Serine proteases, trypsin family, serine active site TK78_RS31740 d4c767f12de01f2811e195b30e9c4a7c 511 SUPERFAMILY SSF56091 180 385 8.63E-48 T 09-03-2017 TK78_RS31740 d4c767f12de01f2811e195b30e9c4a7c 511 Gene3D G3DSA:3.30.1490.70 183 212 1.2E-17 T 09-03-2017 TK78_RS31740 d4c767f12de01f2811e195b30e9c4a7c 511 Gene3D G3DSA:3.30.1490.70 342 386 1.2E-17 T 09-03-2017 TK78_RS31740 d4c767f12de01f2811e195b30e9c4a7c 511 Hamap MF_00407 DNA ligase [lig]. 1 511 26.28 T 09-03-2017 IPR022865 DNA ligase, ATP-dependent, bacterial/archaeal GO:0003910 TK78_RS31740 d4c767f12de01f2811e195b30e9c4a7c 511 SUPERFAMILY SSF50249 387 506 2.31E-29 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS31740 d4c767f12de01f2811e195b30e9c4a7c 511 ProSitePatterns PS00697 ATP-dependent DNA ligase AMP-binding site. 208 216 - T 09-03-2017 IPR016059 DNA ligase, ATP-dependent, conserved site GO:0003909|GO:0051103 TK78_RS31740 d4c767f12de01f2811e195b30e9c4a7c 511 TIGRFAM TIGR00574 dnl1: DNA ligase I, ATP-dependent (dnl1) 69 506 3.0E-81 T 09-03-2017 IPR000977 DNA ligase, ATP-dependent GO:0003910|GO:0005524|GO:0006281|GO:0006310|GO:0071897 TK78_RS31740 d4c767f12de01f2811e195b30e9c4a7c 511 Gene3D G3DSA:3.30.470.30 213 327 1.1E-29 T 09-03-2017 TK78_RS31740 d4c767f12de01f2811e195b30e9c4a7c 511 SUPERFAMILY SSF117018 4 202 4.32E-32 T 09-03-2017 IPR012308 DNA ligase, ATP-dependent, N-terminal GO:0003677|GO:0003910|GO:0006281|GO:0006310 TK78_RS31740 d4c767f12de01f2811e195b30e9c4a7c 511 Pfam PF04675 DNA ligase N terminus 72 138 4.2E-7 T 09-03-2017 IPR012308 DNA ligase, ATP-dependent, N-terminal GO:0003677|GO:0003910|GO:0006281|GO:0006310 TK78_RS31740 d4c767f12de01f2811e195b30e9c4a7c 511 Gene3D G3DSA:1.10.3260.10 70 182 3.4E-21 T 09-03-2017 IPR012308 DNA ligase, ATP-dependent, N-terminal GO:0003677|GO:0003910|GO:0006281|GO:0006310 TK78_RS31740 d4c767f12de01f2811e195b30e9c4a7c 511 Gene3D G3DSA:2.40.50.140 388 507 1.8E-32 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS31740 d4c767f12de01f2811e195b30e9c4a7c 511 Pfam PF01068 ATP dependent DNA ligase domain 186 385 9.3E-44 T 09-03-2017 IPR012310 DNA ligase, ATP-dependent, central GO:0003910|GO:0005524|GO:0006281|GO:0006310 TK78_RS31740 d4c767f12de01f2811e195b30e9c4a7c 511 Pfam PF04679 ATP dependent DNA ligase C terminal region 404 495 1.0E-13 T 09-03-2017 IPR012309 DNA ligase, ATP-dependent, C-terminal GO:0003910|GO:0006281|GO:0006310 TK78_RS12630 1a26af170398cd9121ba825ef286dd31 262 Pfam PF00596 Class II Aldolase and Adducin N-terminal domain 39 218 5.5E-50 T 09-03-2017 IPR001303 Class II aldolase/adducin N-terminal TK78_RS12630 1a26af170398cd9121ba825ef286dd31 262 SUPERFAMILY SSF53639 32 249 1.96E-67 T 09-03-2017 IPR001303 Class II aldolase/adducin N-terminal TK78_RS12630 1a26af170398cd9121ba825ef286dd31 262 Gene3D G3DSA:3.40.225.10 33 241 2.9E-67 T 09-03-2017 IPR001303 Class II aldolase/adducin N-terminal TK78_RS12630 1a26af170398cd9121ba825ef286dd31 262 SMART SM01007 38 218 5.5E-58 T 09-03-2017 IPR001303 Class II aldolase/adducin N-terminal TK78_RS29330 8b711feddd78ea6972e51f013724933f 103 Pfam PF13459 4Fe-4S single cluster domain 18 88 9.2E-19 T 09-03-2017 TK78_RS29330 8b711feddd78ea6972e51f013724933f 103 PRINTS PR00352 3Fe-4S ferredoxin signature 74 86 1.5E-6 T 09-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 TK78_RS29330 8b711feddd78ea6972e51f013724933f 103 PRINTS PR00352 3Fe-4S ferredoxin signature 31 41 1.5E-6 T 09-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 TK78_RS29330 8b711feddd78ea6972e51f013724933f 103 PRINTS PR00352 3Fe-4S ferredoxin signature 20 31 1.5E-6 T 09-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 TK78_RS29330 8b711feddd78ea6972e51f013724933f 103 Gene3D G3DSA:3.30.70.20 16 100 2.9E-28 T 09-03-2017 TK78_RS29330 8b711feddd78ea6972e51f013724933f 103 SUPERFAMILY SSF54862 17 88 6.81E-10 T 09-03-2017 TK78_RS01985 2670b3c4a4aebde2084e85582b9c84ab 270 Gene3D G3DSA:3.75.10.10 5 266 2.4E-62 T 09-03-2017 TK78_RS01985 2670b3c4a4aebde2084e85582b9c84ab 270 SUPERFAMILY SSF55909 7 269 1.96E-53 T 09-03-2017 TK78_RS01985 2670b3c4a4aebde2084e85582b9c84ab 270 Pfam PF02274 Amidinotransferase 40 268 1.9E-12 T 09-03-2017 TK78_RS20080 ec38bdd3f95c3947add4ab5dba1bbead 497 SUPERFAMILY SSF47413 6 71 1.62E-5 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS20080 ec38bdd3f95c3947add4ab5dba1bbead 497 Gene3D G3DSA:1.10.260.40 8 70 1.4E-4 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS20080 ec38bdd3f95c3947add4ab5dba1bbead 497 Pfam PF13560 Helix-turn-helix domain 8 70 2.9E-10 T 09-03-2017 TK78_RS02860 f45b2a4660c726356faa9b77ed4d29ed 320 SMART SM00304 57 109 1.9E-6 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS02860 f45b2a4660c726356faa9b77ed4d29ed 320 SUPERFAMILY SSF55874 206 311 2.26E-12 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS02860 f45b2a4660c726356faa9b77ed4d29ed 320 SMART SM00387 224 314 6.4E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS02860 f45b2a4660c726356faa9b77ed4d29ed 320 Pfam PF07730 Histidine kinase 122 186 6.4E-17 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS02860 f45b2a4660c726356faa9b77ed4d29ed 320 Gene3D G3DSA:3.30.565.10 227 313 5.4E-5 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS29085 3e740c58c70c1aec6b5fcfad2f5a4ae3 197 SUPERFAMILY SSF48498 84 196 1.52E-19 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS29085 3e740c58c70c1aec6b5fcfad2f5a4ae3 197 Gene3D G3DSA:1.10.357.10 60 197 8.1E-40 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS29085 3e740c58c70c1aec6b5fcfad2f5a4ae3 197 ProSitePatterns PS01081 TetR-type HTH domain signature. 28 59 - T 09-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site TK78_RS29085 3e740c58c70c1aec6b5fcfad2f5a4ae3 197 Pfam PF00440 Bacterial regulatory proteins, tetR family 16 62 1.1E-23 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS29085 3e740c58c70c1aec6b5fcfad2f5a4ae3 197 SUPERFAMILY SSF46689 7 88 4.44E-23 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS29085 3e740c58c70c1aec6b5fcfad2f5a4ae3 197 Gene3D G3DSA:1.10.10.60 8 59 2.1E-25 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS29085 3e740c58c70c1aec6b5fcfad2f5a4ae3 197 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 16 29 1.7E-14 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS29085 3e740c58c70c1aec6b5fcfad2f5a4ae3 197 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 37 60 1.7E-14 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS25385 3a078ccac285861c5e7e4b9e4f0b1f38 143 SUPERFAMILY SSF46785 1 57 1.03E-15 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS25385 3a078ccac285861c5e7e4b9e4f0b1f38 143 Pfam PF13404 AsnC-type helix-turn-helix domain 1 42 1.1E-16 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS25385 3a078ccac285861c5e7e4b9e4f0b1f38 143 Gene3D G3DSA:1.10.10.10 1 52 1.1E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS25385 3a078ccac285861c5e7e4b9e4f0b1f38 143 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 28 47 5.1E-15 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS25385 3a078ccac285861c5e7e4b9e4f0b1f38 143 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 17 28 5.1E-15 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS25385 3a078ccac285861c5e7e4b9e4f0b1f38 143 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 1 17 5.1E-15 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS25385 3a078ccac285861c5e7e4b9e4f0b1f38 143 SMART SM00344 1 109 2.4E-30 T 09-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 TK78_RS25385 3a078ccac285861c5e7e4b9e4f0b1f38 143 Gene3D G3DSA:3.30.70.920 63 134 3.6E-15 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS25385 3a078ccac285861c5e7e4b9e4f0b1f38 143 Pfam PF01037 Lrp/AsnC ligand binding domain 73 138 1.3E-13 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS25385 3a078ccac285861c5e7e4b9e4f0b1f38 143 ProSitePatterns PS00519 AsnC-type HTH domain signature. 19 45 - T 09-03-2017 IPR019885 Transcription regulator HTH, AsnC-type, conserved site TK78_RS25385 3a078ccac285861c5e7e4b9e4f0b1f38 143 SUPERFAMILY SSF54909 64 139 1.88E-12 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS27525 8bc2df6a0510d164b763fa68aa644afc 287 SUPERFAMILY SSF51215 1 155 5.62E-20 T 09-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 TK78_RS27525 8bc2df6a0510d164b763fa68aa644afc 287 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 215 257 - T 09-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 TK78_RS27525 8bc2df6a0510d164b763fa68aa644afc 287 Gene3D G3DSA:2.60.120.280 12 155 1.0E-16 T 09-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 TK78_RS27525 8bc2df6a0510d164b763fa68aa644afc 287 SUPERFAMILY SSF46689 214 264 1.75E-12 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS27525 8bc2df6a0510d164b763fa68aa644afc 287 Gene3D G3DSA:1.10.10.60 216 264 1.4E-15 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS27525 8bc2df6a0510d164b763fa68aa644afc 287 Gene3D G3DSA:1.10.10.60 168 215 1.1E-5 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS27525 8bc2df6a0510d164b763fa68aa644afc 287 SMART SM00342 178 261 1.0E-22 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS27525 8bc2df6a0510d164b763fa68aa644afc 287 Pfam PF02311 AraC-like ligand binding domain 26 140 1.2E-9 T 09-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 TK78_RS27525 8bc2df6a0510d164b763fa68aa644afc 287 Pfam PF12833 Helix-turn-helix domain 185 262 8.7E-19 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS27525 8bc2df6a0510d164b763fa68aa644afc 287 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 230 245 9.2E-5 T 09-03-2017 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 TK78_RS27525 8bc2df6a0510d164b763fa68aa644afc 287 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 245 261 9.2E-5 T 09-03-2017 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 TK78_RS18115 9cf78c5b0f9e0ee4fea7b39d82fb8bd2 809 Pfam PF13424 Tetratricopeptide repeat 707 779 7.6E-13 T 09-03-2017 TK78_RS18115 9cf78c5b0f9e0ee4fea7b39d82fb8bd2 809 SUPERFAMILY SSF48452 542 650 1.57E-9 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS18115 9cf78c5b0f9e0ee4fea7b39d82fb8bd2 809 Gene3D G3DSA:1.25.40.10 543 766 3.5E-10 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS18115 9cf78c5b0f9e0ee4fea7b39d82fb8bd2 809 Pfam PF13676 TIR domain 12 108 8.4E-19 T 09-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 TK78_RS18115 9cf78c5b0f9e0ee4fea7b39d82fb8bd2 809 Gene3D G3DSA:3.40.50.10140 12 77 2.6E-4 T 09-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 TK78_RS18115 9cf78c5b0f9e0ee4fea7b39d82fb8bd2 809 SUPERFAMILY SSF52200 12 99 1.7E-10 T 09-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 TK78_RS18115 9cf78c5b0f9e0ee4fea7b39d82fb8bd2 809 Gene3D G3DSA:3.40.50.300 171 281 1.3E-4 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18115 9cf78c5b0f9e0ee4fea7b39d82fb8bd2 809 Pfam PF00931 NB-ARC domain 180 328 5.7E-6 T 09-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 TK78_RS18115 9cf78c5b0f9e0ee4fea7b39d82fb8bd2 809 Pfam PF13374 Tetratricopeptide repeat 663 704 3.1E-12 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS18115 9cf78c5b0f9e0ee4fea7b39d82fb8bd2 809 Pfam PF13374 Tetratricopeptide repeat 579 620 2.4E-9 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS18115 9cf78c5b0f9e0ee4fea7b39d82fb8bd2 809 Pfam PF13374 Tetratricopeptide repeat 621 661 5.6E-12 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS18115 9cf78c5b0f9e0ee4fea7b39d82fb8bd2 809 SUPERFAMILY SSF52540 160 362 3.29E-20 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18115 9cf78c5b0f9e0ee4fea7b39d82fb8bd2 809 SUPERFAMILY SSF48452 657 776 6.01E-13 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS15235 a4f1199c6c1f65c8357b120f29a314d8 321 Gene3D G3DSA:3.40.50.300 2 218 3.3E-55 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15235 a4f1199c6c1f65c8357b120f29a314d8 321 SMART SM00382 26 204 1.3E-8 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS15235 a4f1199c6c1f65c8357b120f29a314d8 321 Pfam PF00005 ABC transporter 18 156 2.1E-22 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS15235 a4f1199c6c1f65c8357b120f29a314d8 321 SUPERFAMILY SSF52540 2 217 1.98E-51 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29700 7d1f3f6f722307d4644af67e9a87b832 69 SUPERFAMILY SSF50118 1 66 3.33E-25 T 09-03-2017 IPR011067 Plasmid maintenance toxin/Cell growth inhibitor TK78_RS29700 7d1f3f6f722307d4644af67e9a87b832 69 Pfam PF08940 Domain of unknown function (DUF1918) 1 57 6.2E-27 T 09-03-2017 IPR015035 Domain of unknown function DUF1918 TK78_RS29875 a5c31d9bfa9f06f145f2a8f5da75fcc6 181 SUPERFAMILY SSF88659 97 172 1.14E-8 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS29875 a5c31d9bfa9f06f145f2a8f5da75fcc6 181 Gene3D G3DSA:1.10.1740.10 17 104 3.4E-4 T 09-03-2017 TK78_RS29875 a5c31d9bfa9f06f145f2a8f5da75fcc6 181 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 17 170 2.9E-13 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS29875 a5c31d9bfa9f06f145f2a8f5da75fcc6 181 SUPERFAMILY SSF88946 14 91 7.06E-5 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS29875 a5c31d9bfa9f06f145f2a8f5da75fcc6 181 Gene3D G3DSA:1.10.10.10 109 171 4.6E-4 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS13015 b208cc5ca4bde8754a78cafb7f903d6f 284 PIRSF PIRSF001430 10 276 8.4E-74 T 09-03-2017 IPR001406 Pseudouridine synthase I, TruA GO:0001522|GO:0003723|GO:0009451|GO:0009982 TK78_RS13015 b208cc5ca4bde8754a78cafb7f903d6f 284 SUPERFAMILY SSF55120 9 265 2.3E-71 T 09-03-2017 IPR020103 Pseudouridine synthase, catalytic domain GO:0001522|GO:0003723|GO:0009451|GO:0009982 TK78_RS13015 b208cc5ca4bde8754a78cafb7f903d6f 284 Pfam PF01416 tRNA pseudouridine synthase 157 260 1.0E-21 T 09-03-2017 IPR020097 Pseudouridine synthase I, TruA, alpha/beta domain GO:0001522|GO:0003723|GO:0009451|GO:0009982 TK78_RS13015 b208cc5ca4bde8754a78cafb7f903d6f 284 Pfam PF01416 tRNA pseudouridine synthase 18 116 9.5E-6 T 09-03-2017 IPR020097 Pseudouridine synthase I, TruA, alpha/beta domain GO:0001522|GO:0003723|GO:0009451|GO:0009982 TK78_RS13015 b208cc5ca4bde8754a78cafb7f903d6f 284 Hamap MF_00171 tRNA pseudouridine synthase A [truA]. 10 259 30.747 T 09-03-2017 IPR001406 Pseudouridine synthase I, TruA GO:0001522|GO:0003723|GO:0009451|GO:0009982 TK78_RS13015 b208cc5ca4bde8754a78cafb7f903d6f 284 TIGRFAM TIGR00071 hisT_truA: tRNA pseudouridine(38-40) synthase 12 241 2.2E-47 T 09-03-2017 IPR001406 Pseudouridine synthase I, TruA GO:0001522|GO:0003723|GO:0009451|GO:0009982 TK78_RS13015 b208cc5ca4bde8754a78cafb7f903d6f 284 Gene3D G3DSA:3.30.70.580 10 118 9.7E-33 T 09-03-2017 IPR020094 Pseudouridine synthase I, TruA, N-terminal GO:0001522|GO:0003723|GO:0009451|GO:0009982 TK78_RS13015 b208cc5ca4bde8754a78cafb7f903d6f 284 Gene3D G3DSA:3.30.70.660 120 257 4.0E-36 T 09-03-2017 IPR020095 Pseudouridine synthase I, TruA, C-terminal GO:0001522|GO:0003723|GO:0009451|GO:0009982 TK78_RS24355 051cb71caa4c6c5180f8a9236d1f2837 162 PIRSF PIRSF005384 1 149 4.3E-50 T 09-03-2017 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26 TK78_RS24355 051cb71caa4c6c5180f8a9236d1f2837 162 SUPERFAMILY SSF89623 1 152 1.15E-52 T 09-03-2017 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26 TK78_RS24355 051cb71caa4c6c5180f8a9236d1f2837 162 Gene3D G3DSA:3.40.1400.10 1 150 6.2E-55 T 09-03-2017 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26 TK78_RS24355 051cb71caa4c6c5180f8a9236d1f2837 162 TIGRFAM TIGR02133 RPI_actino: ribose 5-phosphate isomerase 1 148 9.7E-72 T 09-03-2017 IPR011860 Ribose 5-phosphate isomerase GO:0004751 TK78_RS24355 051cb71caa4c6c5180f8a9236d1f2837 162 TIGRFAM TIGR00689 rpiB_lacA_lacB: sugar-phosphate isomerase, RpiB/LacA/LacB family 3 147 4.6E-54 T 09-03-2017 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26 TK78_RS24355 051cb71caa4c6c5180f8a9236d1f2837 162 Pfam PF02502 Ribose/Galactose Isomerase 3 142 7.1E-46 T 09-03-2017 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26 TK78_RS07350 4d54b8373ad9ded68f13468abbaf753d 265 Gene3D G3DSA:2.10.109.10 146 264 7.8E-45 T 09-03-2017 IPR028360 Peptidase S24/S26, beta-ribbon domain TK78_RS07350 4d54b8373ad9ded68f13468abbaf753d 265 PRINTS PR00726 Repressor LexA serine protease (S24) family signature 220 232 5.4E-11 T 09-03-2017 IPR006197 Peptidase S24, LexA-like GO:0003677|GO:0006355 TK78_RS07350 4d54b8373ad9ded68f13468abbaf753d 265 PRINTS PR00726 Repressor LexA serine protease (S24) family signature 181 191 5.4E-11 T 09-03-2017 IPR006197 Peptidase S24, LexA-like GO:0003677|GO:0006355 TK78_RS07350 4d54b8373ad9ded68f13468abbaf753d 265 PRINTS PR00726 Repressor LexA serine protease (S24) family signature 192 203 5.4E-11 T 09-03-2017 IPR006197 Peptidase S24, LexA-like GO:0003677|GO:0006355 TK78_RS07350 4d54b8373ad9ded68f13468abbaf753d 265 SUPERFAMILY SSF46785 59 125 3.21E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS07350 4d54b8373ad9ded68f13468abbaf753d 265 Pfam PF00717 Peptidase S24-like 184 248 4.9E-16 T 09-03-2017 IPR019759 Peptidase S24/S26A/S26B TK78_RS07350 4d54b8373ad9ded68f13468abbaf753d 265 TIGRFAM TIGR00498 lexA: repressor LexA 58 265 5.4E-75 T 09-03-2017 IPR006200 Transcription regulator LexA GO:0004252|GO:0009432|GO:0045892 TK78_RS07350 4d54b8373ad9ded68f13468abbaf753d 265 Hamap MF_00015 LexA repressor [lexA]. 59 265 34.262 T 09-03-2017 IPR006200 Transcription regulator LexA GO:0004252|GO:0009432|GO:0045892 TK78_RS07350 4d54b8373ad9ded68f13468abbaf753d 265 Gene3D G3DSA:1.10.10.10 59 125 1.9E-32 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS07350 4d54b8373ad9ded68f13468abbaf753d 265 SUPERFAMILY SSF51306 145 263 2.44E-36 T 09-03-2017 IPR015927 Peptidase S24/S26A/S26B/S26C TK78_RS07350 4d54b8373ad9ded68f13468abbaf753d 265 Pfam PF01726 LexA DNA binding domain 58 121 1.1E-29 T 09-03-2017 IPR006199 LexA repressor, DNA-binding domain GO:0004252|GO:0006508 TK78_RS26885 0de18761d5148a0fab822877b0fc2f08 251 Gene3D G3DSA:3.60.10.10 18 243 3.3E-7 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS26885 0de18761d5148a0fab822877b0fc2f08 251 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 22 238 4.4E-11 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS26885 0de18761d5148a0fab822877b0fc2f08 251 SUPERFAMILY SSF56219 19 246 6.28E-25 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS10855 eb6590e3d5c1f722d21b18a44b4f23b5 293 Pfam PF13371 Tetratricopeptide repeat 211 293 4.0E-12 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS10855 eb6590e3d5c1f722d21b18a44b4f23b5 293 Pfam PF13369 Transglutaminase-like superfamily 64 209 2.0E-41 T 09-03-2017 IPR032698 Protein SirB1, N-terminal TK78_RS20755 b8d9df0c7783b79d73ae169369cd6d87 406 SUPERFAMILY SSF48452 148 342 5.91E-8 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS20755 b8d9df0c7783b79d73ae169369cd6d87 406 Pfam PF13560 Helix-turn-helix domain 7 62 2.9E-9 T 09-03-2017 TK78_RS20755 b8d9df0c7783b79d73ae169369cd6d87 406 Gene3D G3DSA:1.10.260.40 6 68 4.3E-14 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS20755 b8d9df0c7783b79d73ae169369cd6d87 406 Gene3D G3DSA:1.25.40.10 69 383 2.0E-13 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS20755 b8d9df0c7783b79d73ae169369cd6d87 406 SUPERFAMILY SSF47413 6 66 1.89E-11 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS20755 b8d9df0c7783b79d73ae169369cd6d87 406 SMART SM00530 10 64 6.9E-9 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS08155 2ab52bbb273016391c8e6b9411d693f2 273 PIRSF PIRSF000386 1 258 3.4E-92 T 09-03-2017 IPR002649 tRNA (guanine-N1-)-methyltransferase, bacteria GO:0008033|GO:0052906 KEGG: 00340+2.1.1.22|MetaCyc: PWY-6829|MetaCyc: PWY-7285|MetaCyc: PWY-7286 TK78_RS08155 2ab52bbb273016391c8e6b9411d693f2 273 Pfam PF01746 tRNA (Guanine-1)-methyltransferase 22 232 1.1E-69 T 09-03-2017 IPR016009 tRNA methyltransferase TRMD/TRM10-type domain KEGG: 00340+2.1.1.22|MetaCyc: PWY-6829|MetaCyc: PWY-7285|MetaCyc: PWY-7286 TK78_RS08155 2ab52bbb273016391c8e6b9411d693f2 273 Gene3D G3DSA:1.10.1270.20 168 252 9.9E-29 T 09-03-2017 IPR023148 tRNA (guanine-N1-)-methyltransferase, C-terminal GO:0008033|GO:0052906 KEGG: 00340+2.1.1.22|MetaCyc: PWY-6829|MetaCyc: PWY-7285|MetaCyc: PWY-7286 TK78_RS08155 2ab52bbb273016391c8e6b9411d693f2 273 Hamap MF_00605 tRNA (guanine-N(1)-)-methyltransferase [trmD]. 1 273 99.312 T 09-03-2017 IPR002649 tRNA (guanine-N1-)-methyltransferase, bacteria GO:0008033|GO:0052906 KEGG: 00340+2.1.1.22|MetaCyc: PWY-6829|MetaCyc: PWY-7285|MetaCyc: PWY-7286 TK78_RS08155 2ab52bbb273016391c8e6b9411d693f2 273 SUPERFAMILY SSF75217 1 246 2.53E-83 T 09-03-2017 IPR029028 Alpha/beta knot methyltransferases TK78_RS08155 2ab52bbb273016391c8e6b9411d693f2 273 TIGRFAM TIGR00088 trmD: tRNA (guanine(37)-N(1))-methyltransferase 1 238 7.9E-66 T 09-03-2017 IPR002649 tRNA (guanine-N1-)-methyltransferase, bacteria GO:0008033|GO:0052906 KEGG: 00340+2.1.1.22|MetaCyc: PWY-6829|MetaCyc: PWY-7285|MetaCyc: PWY-7286 TK78_RS08155 2ab52bbb273016391c8e6b9411d693f2 273 Gene3D G3DSA:3.40.1280.10 1 167 7.4E-61 T 09-03-2017 IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal TK78_RS27855 3c340e22253c19e0c7bfc6d2075a7e10 298 SUPERFAMILY SSF52540 16 168 7.06E-14 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27855 3c340e22253c19e0c7bfc6d2075a7e10 298 Hamap MF_00636 RNase adapter protein RapZ [rapZ]. 15 297 41.045 T 09-03-2017 IPR005337 RapZ-like family GO:0005524 TK78_RS27855 3c340e22253c19e0c7bfc6d2075a7e10 298 Gene3D G3DSA:3.40.50.300 14 169 4.5E-20 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27855 3c340e22253c19e0c7bfc6d2075a7e10 298 Pfam PF03668 P-loop ATPase protein family 16 298 5.8E-111 T 09-03-2017 IPR005337 RapZ-like family GO:0005524 TK78_RS27855 3c340e22253c19e0c7bfc6d2075a7e10 298 PIRSF PIRSF005052 15 298 5.0E-111 T 09-03-2017 IPR005337 RapZ-like family GO:0005524 TK78_RS29440 4970fc2d6e253c9bdb1401e4772cd1dc 215 Gene3D G3DSA:2.30.180.10 83 214 6.5E-34 T 09-03-2017 IPR000782 FAS1 domain TK78_RS29440 4970fc2d6e253c9bdb1401e4772cd1dc 215 Pfam PF02469 Fasciclin domain 93 213 3.1E-32 T 09-03-2017 IPR000782 FAS1 domain TK78_RS29440 4970fc2d6e253c9bdb1401e4772cd1dc 215 SMART SM00554 117 214 1.8E-30 T 09-03-2017 IPR000782 FAS1 domain TK78_RS29440 4970fc2d6e253c9bdb1401e4772cd1dc 215 SUPERFAMILY SSF82153 77 214 2.75E-36 T 09-03-2017 IPR000782 FAS1 domain TK78_RS31485 40cf06525a02f8c892b5c99c5a151509 256 Gene3D G3DSA:1.10.10.10 10 75 2.8E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS31485 40cf06525a02f8c892b5c99c5a151509 256 Pfam PF07702 UTRA domain 103 231 9.2E-15 T 09-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 TK78_RS31485 40cf06525a02f8c892b5c99c5a151509 256 SUPERFAMILY SSF64288 63 237 2.67E-26 T 09-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain TK78_RS31485 40cf06525a02f8c892b5c99c5a151509 256 SUPERFAMILY SSF46785 13 79 1.48E-16 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS31485 40cf06525a02f8c892b5c99c5a151509 256 Gene3D G3DSA:3.40.1410.10 76 236 6.4E-24 T 09-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain TK78_RS31485 40cf06525a02f8c892b5c99c5a151509 256 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 49 65 6.9E-10 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS31485 40cf06525a02f8c892b5c99c5a151509 256 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 35 49 6.9E-10 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS31485 40cf06525a02f8c892b5c99c5a151509 256 Pfam PF00392 Bacterial regulatory proteins, gntR family 26 75 4.5E-15 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS31485 40cf06525a02f8c892b5c99c5a151509 256 SMART SM00866 94 234 8.1E-15 T 09-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 TK78_RS31485 40cf06525a02f8c892b5c99c5a151509 256 SMART SM00345 17 75 3.6E-12 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS13385 6038f2d08bf5427018d7fe8234ffa7d7 563 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 246 270 1.0E-40 T 09-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13385 6038f2d08bf5427018d7fe8234ffa7d7 563 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 144 163 1.0E-40 T 09-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13385 6038f2d08bf5427018d7fe8234ffa7d7 563 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 397 423 1.0E-40 T 09-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13385 6038f2d08bf5427018d7fe8234ffa7d7 563 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 174 198 1.0E-40 T 09-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13385 6038f2d08bf5427018d7fe8234ffa7d7 563 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 340 359 1.0E-40 T 09-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13385 6038f2d08bf5427018d7fe8234ffa7d7 563 TIGRFAM TIGR01972 NDH_I_M: proton-translocating NADH-quinone oxidoreductase, chain M 5 559 1.2E-164 T 09-03-2017 IPR010227 NADH-quinone oxidoreductase, chain M/4 GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13385 6038f2d08bf5427018d7fe8234ffa7d7 563 Pfam PF00361 Proton-conducting membrane transporter 140 424 6.4E-63 T 09-03-2017 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS26055 8bd32751bfef0034217a991393a449e7 184 SUPERFAMILY SSF55729 3 170 6.71E-40 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS26055 8bd32751bfef0034217a991393a449e7 184 Pfam PF13302 Acetyltransferase (GNAT) domain 7 146 1.0E-24 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS26055 8bd32751bfef0034217a991393a449e7 184 Gene3D G3DSA:3.40.630.30 4 173 6.5E-42 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS18770 cee50aaabc269bb8a1528a45d0cda67d 337 Pfam PF12833 Helix-turn-helix domain 236 314 5.5E-22 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS18770 cee50aaabc269bb8a1528a45d0cda67d 337 SMART SM00342 230 313 2.9E-26 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS18770 cee50aaabc269bb8a1528a45d0cda67d 337 SUPERFAMILY SSF52317 2 188 9.9E-45 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS18770 cee50aaabc269bb8a1528a45d0cda67d 337 Gene3D G3DSA:1.10.10.60 268 314 1.3E-11 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS18770 cee50aaabc269bb8a1528a45d0cda67d 337 Gene3D G3DSA:1.10.10.60 213 267 8.8E-15 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS18770 cee50aaabc269bb8a1528a45d0cda67d 337 Gene3D G3DSA:3.40.50.880 3 188 6.0E-47 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS18770 cee50aaabc269bb8a1528a45d0cda67d 337 Pfam PF01965 DJ-1/PfpI family 45 167 3.2E-16 T 09-03-2017 IPR002818 DJ-1/PfpI TK78_RS18770 cee50aaabc269bb8a1528a45d0cda67d 337 SUPERFAMILY SSF46689 267 315 8.96E-9 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS18770 cee50aaabc269bb8a1528a45d0cda67d 337 SUPERFAMILY SSF46689 216 264 1.39E-8 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS18770 cee50aaabc269bb8a1528a45d0cda67d 337 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 267 309 - T 09-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 TK78_RS34810 1fa212ee5100edc3a69f1f7fd0515360 616 PRINTS PR00364 Disease resistance protein signature 31 46 2.2E-7 T 09-03-2017 TK78_RS34810 1fa212ee5100edc3a69f1f7fd0515360 616 PRINTS PR00364 Disease resistance protein signature 202 216 2.2E-7 T 09-03-2017 TK78_RS34810 1fa212ee5100edc3a69f1f7fd0515360 616 Pfam PF13374 Tetratricopeptide repeat 545 586 5.8E-11 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS34810 1fa212ee5100edc3a69f1f7fd0515360 616 Gene3D G3DSA:3.40.50.300 27 78 3.7E-6 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS34810 1fa212ee5100edc3a69f1f7fd0515360 616 SUPERFAMILY SSF52540 3 270 1.56E-17 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS34810 1fa212ee5100edc3a69f1f7fd0515360 616 SUPERFAMILY SSF48452 457 601 6.5E-18 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS34810 1fa212ee5100edc3a69f1f7fd0515360 616 Gene3D G3DSA:1.25.40.10 426 599 1.0E-16 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS34810 1fa212ee5100edc3a69f1f7fd0515360 616 Pfam PF13424 Tetratricopeptide repeat 461 529 5.3E-14 T 09-03-2017 TK78_RS08990 d0abe9e822ec1d263e14672fdd7c3b18 461 Gene3D G3DSA:3.30.1330.90 11 158 3.4E-56 T 09-03-2017 IPR029009 Allosteric substrate binding domain Reactome: R-HSA-977347 TK78_RS08990 d0abe9e822ec1d263e14672fdd7c3b18 461 SUPERFAMILY SSF143548 17 158 3.4E-47 T 09-03-2017 IPR029009 Allosteric substrate binding domain Reactome: R-HSA-977347 TK78_RS08990 d0abe9e822ec1d263e14672fdd7c3b18 461 Pfam PF03313 Serine dehydratase alpha chain 189 455 1.1E-103 T 09-03-2017 IPR005130 Serine dehydratase-like, alpha subunit TK78_RS08990 d0abe9e822ec1d263e14672fdd7c3b18 461 TIGRFAM TIGR00720 sda_mono: L-serine ammonia-lyase 3 458 4.3E-208 T 09-03-2017 IPR004644 Iron-sulphur-dependent L-serine dehydratase single chain form GO:0003941|GO:0006094 KEGG: 00260+4.3.1.17|KEGG: 00270+4.3.1.17 TK78_RS08990 d0abe9e822ec1d263e14672fdd7c3b18 461 Pfam PF03315 Serine dehydratase beta chain 4 157 2.1E-60 T 09-03-2017 IPR005131 Serine dehydratase beta chain GO:0003941|GO:0006094|GO:0051539 KEGG: 00260+4.3.1.17|KEGG: 00270+4.3.1.17 TK78_RS32085 5ae2c900a5d41ed150841c42c8d29360 348 Gene3D G3DSA:3.40.50.2300 63 183 4.9E-24 T 09-03-2017 TK78_RS32085 5ae2c900a5d41ed150841c42c8d29360 348 SUPERFAMILY SSF53822 67 336 2.36E-54 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS32085 5ae2c900a5d41ed150841c42c8d29360 348 SUPERFAMILY SSF47413 10 68 5.63E-18 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS32085 5ae2c900a5d41ed150841c42c8d29360 348 Pfam PF13377 Periplasmic binding protein-like domain 177 342 5.2E-36 T 09-03-2017 TK78_RS32085 5ae2c900a5d41ed150841c42c8d29360 348 Gene3D G3DSA:1.10.260.40 11 62 5.9E-26 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS32085 5ae2c900a5d41ed150841c42c8d29360 348 ProSitePatterns PS00356 LacI-type HTH domain signature. 13 31 - T 09-03-2017 TK78_RS32085 5ae2c900a5d41ed150841c42c8d29360 348 Gene3D G3DSA:3.40.50.2300 184 322 2.3E-47 T 09-03-2017 TK78_RS32085 5ae2c900a5d41ed150841c42c8d29360 348 SMART SM00354 10 80 6.5E-29 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS32085 5ae2c900a5d41ed150841c42c8d29360 348 Pfam PF00356 Bacterial regulatory proteins, lacI family 12 57 1.9E-18 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS17720 778495ad932ce9908888583cf91ce87a 386 TIGRFAM TIGR03181 PDH_E1_alph_x: pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit 32 370 8.0E-140 T 09-03-2017 IPR017596 Pyruvate dehydrogenase E1 component subunit alpha/BCKADH E1-alpha KEGG: 00010+1.2.4.1|KEGG: 00020+1.2.4.1|KEGG: 00620+1.2.4.1 TK78_RS17720 778495ad932ce9908888583cf91ce87a 386 Gene3D G3DSA:3.40.50.970 14 370 3.1E-134 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS17720 778495ad932ce9908888583cf91ce87a 386 SUPERFAMILY SSF52518 34 374 5.52E-100 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS17720 778495ad932ce9908888583cf91ce87a 386 Pfam PF00676 Dehydrogenase E1 component 62 343 5.8E-80 T 09-03-2017 IPR001017 Dehydrogenase, E1 component GO:0008152|GO:0016624 TK78_RS16935 e31dcc433e0e2316d71849db14fd3ea7 321 Gene3D G3DSA:3.10.450.50 7 43 1.6E-8 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS16935 e31dcc433e0e2316d71849db14fd3ea7 321 Pfam PF02810 SEC-C motif 27 43 5.4E-8 T 09-03-2017 IPR004027 SEC-C motif TK78_RS16935 e31dcc433e0e2316d71849db14fd3ea7 321 SUPERFAMILY SSF103642 24 43 9.16E-7 T 09-03-2017 TK78_RS01750 1e8560e0af1f7bc0310487fc4d17963d 84 PRINTS PR01249 Ribosomal protein L31 signature 2 19 3.6E-17 T 09-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS01750 1e8560e0af1f7bc0310487fc4d17963d 84 PRINTS PR01249 Ribosomal protein L31 signature 60 78 3.6E-17 T 09-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS01750 1e8560e0af1f7bc0310487fc4d17963d 84 PRINTS PR01249 Ribosomal protein L31 signature 45 60 3.6E-17 T 09-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS01750 1e8560e0af1f7bc0310487fc4d17963d 84 SUPERFAMILY SSF143800 1 79 1.14E-20 T 09-03-2017 TK78_RS01750 1e8560e0af1f7bc0310487fc4d17963d 84 Pfam PF01197 Ribosomal protein L31 1 79 4.3E-29 T 09-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS01750 1e8560e0af1f7bc0310487fc4d17963d 84 TIGRFAM TIGR00105 L31: ribosomal protein bL31 1 80 1.1E-18 T 09-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS01750 1e8560e0af1f7bc0310487fc4d17963d 84 ProSitePatterns PS01143 Ribosomal protein L31 signature. 49 70 - T 09-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS01750 1e8560e0af1f7bc0310487fc4d17963d 84 Hamap MF_00502 50S ribosomal protein L31 type B [rpmE2]. 1 81 25.54 T 09-03-2017 IPR027493 Ribosomal protein L31 type B GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS02990 40342293806180934d9b30697c817a0a 194 SMART SM00065 36 192 0.0079 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS02990 40342293806180934d9b30697c817a0a 194 SUPERFAMILY SSF55781 41 186 2.62E-19 T 09-03-2017 IPR029016 GAF domain-like TK78_RS02990 40342293806180934d9b30697c817a0a 194 Gene3D G3DSA:3.30.450.40 41 185 2.2E-11 T 09-03-2017 IPR029016 GAF domain-like TK78_RS02990 40342293806180934d9b30697c817a0a 194 Pfam PF01590 GAF domain 44 181 3.1E-10 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS05400 29acbedefbe5278911575eb030dbe298 406 SUPERFAMILY SSF53901 4 277 1.99E-76 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS05400 29acbedefbe5278911575eb030dbe298 406 SUPERFAMILY SSF53901 279 403 5.76E-41 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS05400 29acbedefbe5278911575eb030dbe298 406 TIGRFAM TIGR01930 AcCoA-C-Actrans: acetyl-CoA C-acyltransferase 8 402 1.7E-129 T 09-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 TK78_RS05400 29acbedefbe5278911575eb030dbe298 406 Pfam PF02803 Thiolase, C-terminal domain 278 403 2.8E-43 T 09-03-2017 IPR020617 Thiolase, C-terminal GO:0008152|GO:0016747 TK78_RS05400 29acbedefbe5278911575eb030dbe298 406 PIRSF PIRSF000429 2 405 1.2E-124 T 09-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 TK78_RS05400 29acbedefbe5278911575eb030dbe298 406 Pfam PF00108 Thiolase, N-terminal domain 5 269 6.2E-68 T 09-03-2017 IPR020616 Thiolase, N-terminal GO:0008152|GO:0016747 TK78_RS05400 29acbedefbe5278911575eb030dbe298 406 Gene3D G3DSA:3.40.47.10 284 403 2.5E-56 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS05400 29acbedefbe5278911575eb030dbe298 406 Gene3D G3DSA:3.40.47.10 161 198 2.5E-56 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS05400 29acbedefbe5278911575eb030dbe298 406 Gene3D G3DSA:3.40.47.10 199 282 4.1E-63 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS05400 29acbedefbe5278911575eb030dbe298 406 Gene3D G3DSA:3.40.47.10 4 124 4.1E-63 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31650 3a5b4008e1f2c873b63038cead454a1c 238 SUPERFAMILY SSF69593 2 222 4.32E-56 T 09-03-2017 TK78_RS31650 3a5b4008e1f2c873b63038cead454a1c 238 Gene3D G3DSA:3.40.1130.10 3 207 3.8E-36 T 09-03-2017 TK78_RS31650 3a5b4008e1f2c873b63038cead454a1c 238 Pfam PF01553 Acyltransferase 21 151 6.1E-24 T 09-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 TK78_RS31650 3a5b4008e1f2c873b63038cead454a1c 238 SMART SM00563 35 154 2.5E-36 T 09-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 TK78_RS03275 e2acef325da13216a8337e10d7944267 312 Gene3D G3DSA:3.50.50.60 271 311 1.1E-17 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS03275 e2acef325da13216a8337e10d7944267 312 Gene3D G3DSA:3.50.50.60 7 173 1.1E-17 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS03275 e2acef325da13216a8337e10d7944267 312 PIRSF PIRSF000189 5 312 3.1E-71 T 09-03-2017 IPR023209 D-amino-acid oxidase GO:0003884|GO:0046416|GO:0071949 Reactome: R-HSA-389661 TK78_RS03275 e2acef325da13216a8337e10d7944267 312 SUPERFAMILY SSF54373 180 269 1.83E-17 T 09-03-2017 TK78_RS03275 e2acef325da13216a8337e10d7944267 312 ProSitePatterns PS00677 D-amino acid oxidases signature. 286 304 - T 09-03-2017 IPR006181 D-amino acid oxidase, conserved site GO:0003884|GO:0055114 Reactome: R-HSA-389661 TK78_RS03275 e2acef325da13216a8337e10d7944267 312 Gene3D G3DSA:3.30.9.10 174 268 5.5E-38 T 09-03-2017 TK78_RS03275 e2acef325da13216a8337e10d7944267 312 Pfam PF01266 FAD dependent oxidoreductase 8 309 7.3E-36 T 09-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 TK78_RS03275 e2acef325da13216a8337e10d7944267 312 SUPERFAMILY SSF51971 7 193 3.88E-29 T 09-03-2017 TK78_RS03275 e2acef325da13216a8337e10d7944267 312 SUPERFAMILY SSF51971 258 311 3.88E-29 T 09-03-2017 TK78_RS17695 c95b30fd072df7d5aad926ed96549b33 541 SMART SM00220 20 287 2.3E-62 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS17695 c95b30fd072df7d5aad926ed96549b33 541 Gene3D G3DSA:1.10.510.10 116 345 8.8E-47 T 09-03-2017 TK78_RS17695 c95b30fd072df7d5aad926ed96549b33 541 SUPERFAMILY SSF56112 16 291 1.75E-74 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS17695 c95b30fd072df7d5aad926ed96549b33 541 SUPERFAMILY SSF56112 322 378 1.75E-74 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS17695 c95b30fd072df7d5aad926ed96549b33 541 Pfam PF00069 Protein kinase domain 20 282 3.5E-50 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS17695 c95b30fd072df7d5aad926ed96549b33 541 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 26 49 - T 09-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 TK78_RS17695 c95b30fd072df7d5aad926ed96549b33 541 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 147 159 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS17695 c95b30fd072df7d5aad926ed96549b33 541 Gene3D G3DSA:3.30.200.20 13 103 5.4E-26 T 09-03-2017 TK78_RS17695 c95b30fd072df7d5aad926ed96549b33 541 SMART SM00740 470 537 9.5E-8 T 09-03-2017 IPR005543 PASTA domain TK78_RS17695 c95b30fd072df7d5aad926ed96549b33 541 Pfam PF03793 PASTA domain 474 536 6.7E-9 T 09-03-2017 IPR005543 PASTA domain TK78_RS19785 2cb0a548a032be57667773d43ffa4680 189 Pfam PF00583 Acetyltransferase (GNAT) family 73 142 1.0E-9 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS19785 2cb0a548a032be57667773d43ffa4680 189 SUPERFAMILY SSF55729 25 150 1.22E-21 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS19785 2cb0a548a032be57667773d43ffa4680 189 Gene3D G3DSA:3.40.630.30 24 167 7.1E-31 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS10645 80a6504d0c8eeb12ccfdf37023cf2bd5 321 SUPERFAMILY SSF51735 285 314 2.69E-49 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS10645 80a6504d0c8eeb12ccfdf37023cf2bd5 321 SUPERFAMILY SSF51735 1 256 2.69E-49 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS10645 80a6504d0c8eeb12ccfdf37023cf2bd5 321 Gene3D G3DSA:3.40.50.720 202 241 2.1E-34 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS10645 80a6504d0c8eeb12ccfdf37023cf2bd5 321 Gene3D G3DSA:3.40.50.720 1 160 2.1E-34 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS10645 80a6504d0c8eeb12ccfdf37023cf2bd5 321 Gene3D G3DSA:3.90.25.10 185 201 2.5E-5 T 09-03-2017 TK78_RS10645 80a6504d0c8eeb12ccfdf37023cf2bd5 321 Gene3D G3DSA:3.90.25.10 284 313 2.5E-5 T 09-03-2017 TK78_RS10645 80a6504d0c8eeb12ccfdf37023cf2bd5 321 Pfam PF01370 NAD dependent epimerase/dehydratase family 3 222 2.6E-31 T 09-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 TK78_RS05150 8fcbe075b5359a1a65e678e7125b22fe 356 Pfam PF00150 Cellulase (glycosyl hydrolase family 5) 69 319 5.9E-50 T 09-03-2017 IPR001547 Glycoside hydrolase, family 5 GO:0004553|GO:0005975 TK78_RS05150 8fcbe075b5359a1a65e678e7125b22fe 356 ProSitePatterns PS00659 Glycosyl hydrolases family 5 signature. 182 191 - T 09-03-2017 IPR018087 Glycoside hydrolase, family 5, conserved site GO:0004553|GO:0005975 TK78_RS05150 8fcbe075b5359a1a65e678e7125b22fe 356 Gene3D G3DSA:3.20.20.80 53 355 3.3E-92 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS05150 8fcbe075b5359a1a65e678e7125b22fe 356 SUPERFAMILY SSF51445 51 355 5.96E-77 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS20465 f03de299d57387fe7040861991dd27fe 487 Pfam PF00171 Aldehyde dehydrogenase family 14 483 1.3E-158 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS20465 f03de299d57387fe7040861991dd27fe 487 Gene3D G3DSA:3.40.309.10 272 448 1.3E-66 T 09-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 TK78_RS20465 f03de299d57387fe7040861991dd27fe 487 Gene3D G3DSA:3.40.605.10 7 271 6.0E-80 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS20465 f03de299d57387fe7040861991dd27fe 487 SUPERFAMILY SSF53720 7 485 1.96E-151 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS01090 642dd090c52887881156a665c88cdee4 64 SUPERFAMILY SSF52540 24 62 2.75E-5 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01090 642dd090c52887881156a665c88cdee4 64 Gene3D G3DSA:3.40.50.300 22 61 9.8E-5 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS12340 42e604b6e1bdb53c2b40c02e9a3d79f7 176 Pfam PF09349 OHCU decarboxylase 26 86 1.5E-5 T 09-03-2017 IPR018020 Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase KEGG: 00230+4.1.1.97|MetaCyc: PWY-5691|MetaCyc: PWY-7394 TK78_RS12340 42e604b6e1bdb53c2b40c02e9a3d79f7 176 Pfam PF09349 OHCU decarboxylase 98 164 1.6E-9 T 09-03-2017 IPR018020 Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase KEGG: 00230+4.1.1.97|MetaCyc: PWY-5691|MetaCyc: PWY-7394 TK78_RS12340 42e604b6e1bdb53c2b40c02e9a3d79f7 176 Gene3D G3DSA:1.10.3330.10 89 169 3.2E-16 T 09-03-2017 IPR018020 Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase KEGG: 00230+4.1.1.97|MetaCyc: PWY-5691|MetaCyc: PWY-7394 TK78_RS12340 42e604b6e1bdb53c2b40c02e9a3d79f7 176 Gene3D G3DSA:1.10.3330.10 28 86 4.6E-10 T 09-03-2017 IPR018020 Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase KEGG: 00230+4.1.1.97|MetaCyc: PWY-5691|MetaCyc: PWY-7394 TK78_RS12340 42e604b6e1bdb53c2b40c02e9a3d79f7 176 SUPERFAMILY SSF158694 22 167 1.02E-28 T 09-03-2017 TK78_RS23325 45235fb77190d0c19d175a35d5dd7bdc 464 Pfam PF13193 AMP-binding enzyme C-terminal domain 366 432 1.1E-6 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS23325 45235fb77190d0c19d175a35d5dd7bdc 464 Gene3D G3DSA:3.30.300.30 363 436 4.5E-8 T 09-03-2017 TK78_RS23325 45235fb77190d0c19d175a35d5dd7bdc 464 Gene3D G3DSA:3.40.50.980 27 145 6.3E-15 T 09-03-2017 TK78_RS23325 45235fb77190d0c19d175a35d5dd7bdc 464 Gene3D G3DSA:3.40.50.980 146 284 6.6E-23 T 09-03-2017 TK78_RS23325 45235fb77190d0c19d175a35d5dd7bdc 464 SUPERFAMILY SSF56801 27 435 6.02E-64 T 09-03-2017 TK78_RS23325 45235fb77190d0c19d175a35d5dd7bdc 464 Pfam PF00501 AMP-binding enzyme 28 308 2.2E-38 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS23325 45235fb77190d0c19d175a35d5dd7bdc 464 ProSitePatterns PS00455 Putative AMP-binding domain signature. 135 146 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS17320 ae28c8593c356cf5c7407a7a226316f1 205 SUPERFAMILY SSF55729 1 140 5.49E-12 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS17320 ae28c8593c356cf5c7407a7a226316f1 205 Pfam PF00583 Acetyltransferase (GNAT) family 65 139 4.6E-7 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS17320 ae28c8593c356cf5c7407a7a226316f1 205 Gene3D G3DSA:3.40.630.30 4 135 8.2E-10 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS11150 87fec6b442ee0b00836d102f647a39fd 354 SMART SM00331 136 351 4.5E-36 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS11150 87fec6b442ee0b00836d102f647a39fd 354 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 164 351 5.0E-46 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS11150 87fec6b442ee0b00836d102f647a39fd 354 SUPERFAMILY SSF81606 149 350 2.25E-9 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS02375 eb516636eb19dc0abd9b4c50b06917f8 136 SUPERFAMILY SSF55298 5 135 1.88E-27 T 09-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like TK78_RS02375 eb516636eb19dc0abd9b4c50b06917f8 136 Gene3D G3DSA:3.30.1330.40 2 135 4.6E-34 T 09-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like TK78_RS02375 eb516636eb19dc0abd9b4c50b06917f8 136 Pfam PF01042 Endoribonuclease L-PSP 14 133 3.6E-19 T 09-03-2017 IPR006175 YjgF/YER057c/UK114 family TK78_RS08895 37b63679ebc6c6ea1733c0e73407be70 378 Gene3D G3DSA:2.40.30.10 290 370 4.9E-20 T 09-03-2017 TK78_RS08895 37b63679ebc6c6ea1733c0e73407be70 378 SUPERFAMILY SSF52402 10 254 5.29E-46 T 09-03-2017 TK78_RS08895 37b63679ebc6c6ea1733c0e73407be70 378 Gene3D G3DSA:3.40.50.620 3 220 1.6E-76 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS08895 37b63679ebc6c6ea1733c0e73407be70 378 TIGRFAM TIGR00420 trmU: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase 11 365 3.2E-88 T 09-03-2017 IPR004506 tRNA-specific 2-thiouridylase GO:0008033|GO:0016740 Reactome: R-HSA-6787450 TK78_RS08895 37b63679ebc6c6ea1733c0e73407be70 378 Gene3D G3DSA:2.30.30.280 227 284 3.2E-15 T 09-03-2017 IPR023382 Adenine nucleotide alpha hydrolase-like domains GO:0016783 Reactome: R-HSA-6787450 TK78_RS08895 37b63679ebc6c6ea1733c0e73407be70 378 Pfam PF03054 tRNA methyl transferase 10 365 1.7E-117 T 09-03-2017 TK78_RS08895 37b63679ebc6c6ea1733c0e73407be70 378 Hamap MF_00144 tRNA-specific 2-thiouridylase MnmA [mnmA]. 9 366 36.149 T 09-03-2017 IPR004506 tRNA-specific 2-thiouridylase GO:0008033|GO:0016740 Reactome: R-HSA-6787450 TK78_RS21365 cc0c95a830d1a52ceeaa0bcaa9d40c66 482 Hamap MF_01631 Bifunctional protein GlmU [glmU]. 6 460 39.931 T 09-03-2017 IPR005882 Bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase GO:0000287|GO:0000902|GO:0003977|GO:0005737|GO:0009103|GO:0009252|GO:0019134 KEGG: 00520+2.3.1.157+2.7.7.23|KEGG: 00561+2.3.1.15|KEGG: 00564+2.3.1.15|MetaCyc: PWY-5514|MetaCyc: PWY-5667|MetaCyc: PWY-6453|MetaCyc: PWY-7411|MetaCyc: PWY-7587 TK78_RS21365 cc0c95a830d1a52ceeaa0bcaa9d40c66 482 Pfam PF12804 MobA-like NTP transferase domain 9 139 8.9E-21 T 09-03-2017 IPR025877 MobA-like NTP transferase TK78_RS21365 cc0c95a830d1a52ceeaa0bcaa9d40c66 482 SUPERFAMILY SSF51161 257 469 2.27E-42 T 09-03-2017 IPR011004 Trimeric LpxA-like TK78_RS21365 cc0c95a830d1a52ceeaa0bcaa9d40c66 482 Gene3D G3DSA:3.90.550.10 4 259 1.3E-71 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS21365 cc0c95a830d1a52ceeaa0bcaa9d40c66 482 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 402 437 1.3E-6 T 09-03-2017 IPR001451 Hexapeptide repeat TK78_RS21365 cc0c95a830d1a52ceeaa0bcaa9d40c66 482 Gene3D G3DSA:2.160.10.10 264 446 3.9E-42 T 09-03-2017 TK78_RS21365 cc0c95a830d1a52ceeaa0bcaa9d40c66 482 SUPERFAMILY SSF53448 8 261 2.21E-59 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS21365 cc0c95a830d1a52ceeaa0bcaa9d40c66 482 TIGRFAM TIGR01173 glmU: UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase 8 462 3.9E-164 T 09-03-2017 IPR005882 Bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase GO:0000287|GO:0000902|GO:0003977|GO:0005737|GO:0009103|GO:0009252|GO:0019134 KEGG: 00520+2.3.1.157+2.7.7.23|KEGG: 00561+2.3.1.15|KEGG: 00564+2.3.1.15|MetaCyc: PWY-5514|MetaCyc: PWY-5667|MetaCyc: PWY-6453|MetaCyc: PWY-7411|MetaCyc: PWY-7587 TK78_RS28730 6c98ff7a11afe036f22827cbb9d720a1 231 SUPERFAMILY SSF52540 12 227 2.0E-35 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28730 6c98ff7a11afe036f22827cbb9d720a1 231 Gene3D G3DSA:3.40.50.300 12 225 7.7E-70 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28730 6c98ff7a11afe036f22827cbb9d720a1 231 TIGRFAM TIGR00017 cmk: cytidylate kinase 12 222 1.3E-61 T 09-03-2017 IPR003136 Cytidylate kinase GO:0004127|GO:0005524|GO:0006139 MetaCyc: PWY-7205 TK78_RS28730 6c98ff7a11afe036f22827cbb9d720a1 231 Pfam PF02224 Cytidylate kinase 14 224 2.8E-64 T 09-03-2017 IPR011994 Cytidylate kinase domain GO:0004127|GO:0005524|GO:0006139 MetaCyc: PWY-7205 TK78_RS28730 6c98ff7a11afe036f22827cbb9d720a1 231 Hamap MF_00238 Cytidylate kinase [cmk]. 12 228 30.498 T 09-03-2017 IPR003136 Cytidylate kinase GO:0004127|GO:0005524|GO:0006139 MetaCyc: PWY-7205 TK78_RS26985 4725eb645be55548b52972eaa70ab4c2 219 SUPERFAMILY SSF51391 11 212 9.55E-60 T 09-03-2017 IPR022998 Thiamin phosphate synthase superfamily KEGG: 00730+2.5.1.3|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6897|MetaCyc: PWY-6907|MetaCyc: PWY-6908|MetaCyc: PWY-7356|MetaCyc: PWY-7357 TK78_RS26985 4725eb645be55548b52972eaa70ab4c2 219 Hamap MF_00097 Thiamine-phosphate synthase [thiE]. 13 215 23.593 T 09-03-2017 IPR003733 Thiamine phosphate synthase GO:0004789|GO:0009228 KEGG: 00730+2.5.1.3|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6897|MetaCyc: PWY-6907|MetaCyc: PWY-6908|MetaCyc: PWY-7356|MetaCyc: PWY-7357 TK78_RS26985 4725eb645be55548b52972eaa70ab4c2 219 Pfam PF02581 Thiamine monophosphate synthase/TENI 16 197 1.7E-50 T 09-03-2017 IPR003733 Thiamine phosphate synthase GO:0004789|GO:0009228 KEGG: 00730+2.5.1.3|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6897|MetaCyc: PWY-6907|MetaCyc: PWY-6908|MetaCyc: PWY-7356|MetaCyc: PWY-7357 TK78_RS26985 4725eb645be55548b52972eaa70ab4c2 219 Gene3D G3DSA:3.20.20.70 6 216 2.5E-71 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS26985 4725eb645be55548b52972eaa70ab4c2 219 TIGRFAM TIGR00693 thiE: thiamine-phosphate diphosphorylase 15 210 1.6E-58 T 09-03-2017 IPR003733 Thiamine phosphate synthase GO:0004789|GO:0009228 KEGG: 00730+2.5.1.3|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6897|MetaCyc: PWY-6907|MetaCyc: PWY-6908|MetaCyc: PWY-7356|MetaCyc: PWY-7357 TK78_RS26280 aeef0c0c4bd62a4b5abf6cc75c763b93 453 Gene3D G3DSA:3.30.590.10 108 440 8.5E-113 T 09-03-2017 IPR014746 Glutamine synthetase/guanido kinase, catalytic domain GO:0003824 TK78_RS26280 aeef0c0c4bd62a4b5abf6cc75c763b93 453 TIGRFAM TIGR00653 GlnA: glutamine synthetase, type I 8 447 6.8E-131 T 09-03-2017 IPR004809 Glutamine synthetase type I GO:0004356|GO:0005737|GO:0009399 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 TK78_RS26280 aeef0c0c4bd62a4b5abf6cc75c763b93 453 SMART SM01230 104 363 3.0E-122 T 09-03-2017 IPR008146 Glutamine synthetase, catalytic domain GO:0004356|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 TK78_RS26280 aeef0c0c4bd62a4b5abf6cc75c763b93 453 Gene3D G3DSA:3.10.20.70 6 107 8.5E-39 T 09-03-2017 IPR008147 Glutamine synthetase, beta-Grasp domain GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 TK78_RS26280 aeef0c0c4bd62a4b5abf6cc75c763b93 453 Pfam PF00120 Glutamine synthetase, catalytic domain 105 447 1.9E-126 T 09-03-2017 IPR008146 Glutamine synthetase, catalytic domain GO:0004356|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 TK78_RS26280 aeef0c0c4bd62a4b5abf6cc75c763b93 453 Pfam PF03951 Glutamine synthetase, beta-Grasp domain 16 98 2.4E-28 T 09-03-2017 IPR008147 Glutamine synthetase, beta-Grasp domain GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 TK78_RS26280 aeef0c0c4bd62a4b5abf6cc75c763b93 453 ProSitePatterns PS00181 Glutamine synthetase putative ATP-binding region signature. 232 247 - T 09-03-2017 IPR027303 Glutamine synthetase, glycine-rich site KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964|Reactome: R-HSA-210455|Reactome: R-HSA-70614 TK78_RS26280 aeef0c0c4bd62a4b5abf6cc75c763b93 453 SUPERFAMILY SSF55931 106 450 1.67E-113 T 09-03-2017 TK78_RS26280 aeef0c0c4bd62a4b5abf6cc75c763b93 453 SUPERFAMILY SSF54368 8 103 3.53E-30 T 09-03-2017 IPR008147 Glutamine synthetase, beta-Grasp domain GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 TK78_RS27560 7c239a6d4a234ba4eca02ab6c4f8c561 113 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 60 75 7.8E-6 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS27560 7c239a6d4a234ba4eca02ab6c4f8c561 113 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 13 28 7.8E-6 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS27560 7c239a6d4a234ba4eca02ab6c4f8c561 113 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 45 60 7.8E-6 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS27560 7c239a6d4a234ba4eca02ab6c4f8c561 113 Gene3D G3DSA:1.10.10.10 10 108 2.2E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS27560 7c239a6d4a234ba4eca02ab6c4f8c561 113 SMART SM00418 11 89 7.9E-18 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS27560 7c239a6d4a234ba4eca02ab6c4f8c561 113 SUPERFAMILY SSF46785 5 88 4.14E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS27560 7c239a6d4a234ba4eca02ab6c4f8c561 113 Pfam PF12840 Helix-turn-helix domain 11 68 3.9E-8 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS25220 6357722f977962b48b20de36e4278913 153 Gene3D G3DSA:3.10.490.10 16 149 3.1E-30 T 09-03-2017 IPR013024 Butirosin biosynthesis, BtrG-like TK78_RS25220 6357722f977962b48b20de36e4278913 153 SUPERFAMILY SSF110857 16 147 1.24E-19 T 09-03-2017 IPR013024 Butirosin biosynthesis, BtrG-like TK78_RS25220 6357722f977962b48b20de36e4278913 153 Pfam PF06094 Gamma-glutamyl cyclotransferase, AIG2-like 17 148 1.3E-23 T 09-03-2017 IPR009288 Gamma-glutamylcyclotransferase, AIG2-like TK78_RS22210 d4afd5e872f515c9c8b1711ef7349054 743 Gene3D G3DSA:3.90.550.10 2 235 4.9E-47 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS22210 d4afd5e872f515c9c8b1711ef7349054 743 Pfam PF04464 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase 347 709 4.5E-95 T 09-03-2017 IPR007554 CDP-glycerol glycerophosphotransferase GO:0016020|GO:0047355 TK78_RS22210 d4afd5e872f515c9c8b1711ef7349054 743 SUPERFAMILY SSF53448 2 228 4.08E-51 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS22210 d4afd5e872f515c9c8b1711ef7349054 743 SUPERFAMILY SSF53756 508 708 1.85E-5 T 09-03-2017 TK78_RS22210 d4afd5e872f515c9c8b1711ef7349054 743 Pfam PF00535 Glycosyl transferase family 2 5 123 3.9E-31 T 09-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 TK78_RS28595 d41e78bbb50792f6bf5d6e8900b11935 301 Hamap MF_00361 NAD kinase [nadK]. 7 291 29.14 T 09-03-2017 IPR002504 NAD kinase GO:0003951|GO:0006741|GO:0008152 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 TK78_RS28595 d41e78bbb50792f6bf5d6e8900b11935 301 Pfam PF01513 ATP-NAD kinase 53 275 1.7E-57 T 09-03-2017 IPR002504 NAD kinase GO:0003951|GO:0006741|GO:0008152 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 TK78_RS28595 d41e78bbb50792f6bf5d6e8900b11935 301 Gene3D G3DSA:3.40.50.10330 6 153 5.9E-32 T 09-03-2017 IPR017438 Inorganic polyphosphate/ATP-NAD kinase, domain 1 GO:0003951|GO:0008152 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 TK78_RS28595 d41e78bbb50792f6bf5d6e8900b11935 301 SUPERFAMILY SSF111331 8 297 2.49E-78 T 09-03-2017 IPR016064 NAD kinase/diacylglycerol kinase-like domain TK78_RS28595 d41e78bbb50792f6bf5d6e8900b11935 301 Gene3D G3DSA:2.60.200.30 154 265 1.6E-37 T 09-03-2017 IPR017437 ATP-NAD kinase, PpnK-type, all-beta GO:0003951|GO:0008152|GO:0019674 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 TK78_RS34670 e55526e13a472babd7ae1f7d7e737fb2 627 SUPERFAMILY SSF52540 376 623 7.67E-66 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS34670 e55526e13a472babd7ae1f7d7e737fb2 627 Gene3D G3DSA:3.40.50.300 384 615 9.3E-67 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS34670 e55526e13a472babd7ae1f7d7e737fb2 627 SUPERFAMILY SSF90123 50 348 9.03E-11 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS34670 e55526e13a472babd7ae1f7d7e737fb2 627 SMART SM00382 410 600 5.3E-14 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS34670 e55526e13a472babd7ae1f7d7e737fb2 627 Pfam PF00005 ABC transporter 402 554 1.3E-27 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS08765 04a97a6c44ee09da2fc13839f83b2846 530 ProSitePatterns PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 222 238 - T 09-03-2017 IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site TK78_RS08765 04a97a6c44ee09da2fc13839f83b2846 530 Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 7 314 5.7E-33 T 09-03-2017 IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0008152|GO:0016616|GO:0051287|GO:0055114 TK78_RS08765 04a97a6c44ee09da2fc13839f83b2846 530 ProSitePatterns PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 193 215 - T 09-03-2017 IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site TK78_RS08765 04a97a6c44ee09da2fc13839f83b2846 530 SUPERFAMILY SSF55021 455 526 1.79E-15 T 09-03-2017 TK78_RS08765 04a97a6c44ee09da2fc13839f83b2846 530 TIGRFAM TIGR01327 PGDH: phosphoglycerate dehydrogenase 7 527 1.9E-188 T 09-03-2017 IPR006236 D-3-phosphoglycerate dehydrogenase GO:0004617|GO:0006564 KEGG: 00260+1.1.1.95|KEGG: 00680+1.1.1.95|Reactome: R-HSA-977347 TK78_RS08765 04a97a6c44ee09da2fc13839f83b2846 530 Gene3D G3DSA:3.40.50.720 3 108 1.9E-34 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS08765 04a97a6c44ee09da2fc13839f83b2846 530 SUPERFAMILY SSF52283 4 136 3.21E-36 T 09-03-2017 TK78_RS08765 04a97a6c44ee09da2fc13839f83b2846 530 ProSitePatterns PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 145 172 - T 09-03-2017 IPR029752 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 TK78_RS08765 04a97a6c44ee09da2fc13839f83b2846 530 Pfam PF01842 ACT domain 455 516 9.3E-12 T 09-03-2017 IPR002912 ACT domain GO:0008152|GO:0016597 TK78_RS08765 04a97a6c44ee09da2fc13839f83b2846 530 Gene3D G3DSA:3.30.70.260 448 524 4.2E-19 T 09-03-2017 TK78_RS08765 04a97a6c44ee09da2fc13839f83b2846 530 SUPERFAMILY SSF143548 321 450 2.43E-33 T 09-03-2017 IPR029009 Allosteric substrate binding domain Reactome: R-HSA-977347 TK78_RS08765 04a97a6c44ee09da2fc13839f83b2846 530 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 109 282 8.0E-61 T 09-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 TK78_RS08765 04a97a6c44ee09da2fc13839f83b2846 530 Gene3D G3DSA:3.40.50.720 109 284 1.2E-67 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS08765 04a97a6c44ee09da2fc13839f83b2846 530 Gene3D G3DSA:3.30.1330.90 319 447 1.0E-42 T 09-03-2017 IPR029009 Allosteric substrate binding domain Reactome: R-HSA-977347 TK78_RS08765 04a97a6c44ee09da2fc13839f83b2846 530 SUPERFAMILY SSF51735 103 282 2.92E-57 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07585 e68a6a0c867aca56261312e2f3adc681 493 Pfam PF04055 Radical SAM superfamily 194 364 1.3E-19 T 09-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 TK78_RS07585 e68a6a0c867aca56261312e2f3adc681 493 Gene3D G3DSA:3.80.30.20 188 417 1.1E-60 T 09-03-2017 IPR023404 Radical SAM, alpha/beta horseshoe TK78_RS07585 e68a6a0c867aca56261312e2f3adc681 493 SMART SM00729 188 406 5.3E-39 T 09-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 TK78_RS07585 e68a6a0c867aca56261312e2f3adc681 493 SUPERFAMILY SSF102114 178 410 6.41E-44 T 09-03-2017 TK78_RS07585 e68a6a0c867aca56261312e2f3adc681 493 Hamap MF_01865 Ribosomal protein S12 methylthiotransferase RimO [rimO]. 5 485 61.216 T 09-03-2017 IPR005840 Ribosomal protein S12 methylthiotransferase RimO GO:0005737|GO:0016740|GO:0018339|GO:0051539 TK78_RS07585 e68a6a0c867aca56261312e2f3adc681 493 TIGRFAM TIGR00089 TIGR00089: radical SAM methylthiotransferase, MiaB/RimO family 187 480 2.2E-80 T 09-03-2017 IPR005839 Methylthiotransferase GO:0016740|GO:0043412|GO:0051539 TK78_RS07585 e68a6a0c867aca56261312e2f3adc681 493 TIGRFAM TIGR01125 TIGR01125: ribosomal protein S12 methylthiotransferase RimO 7 482 5.2E-117 T 09-03-2017 IPR005840 Ribosomal protein S12 methylthiotransferase RimO GO:0005737|GO:0016740|GO:0018339|GO:0051539 TK78_RS07585 e68a6a0c867aca56261312e2f3adc681 493 Gene3D G3DSA:2.40.50.140 421 486 1.2E-15 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS07585 e68a6a0c867aca56261312e2f3adc681 493 ProSitePatterns PS01278 Methylthiotransferase radical SAM domain signature. 192 212 - T 09-03-2017 IPR020612 Methylthiotransferase, conserved site GO:0051539 TK78_RS07585 e68a6a0c867aca56261312e2f3adc681 493 Pfam PF00919 Uncharacterized protein family UPF0004 7 105 7.2E-31 T 09-03-2017 IPR013848 Methylthiotransferase, N-terminal GO:0003824|GO:0009451|GO:0051539 TK78_RS03830 364f9c8c76ea8ebb839181ad08dfc5dd 307 Gene3D G3DSA:3.40.1190.20 10 306 4.8E-91 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS03830 364f9c8c76ea8ebb839181ad08dfc5dd 307 Pfam PF00294 pfkB family carbohydrate kinase 12 300 5.6E-60 T 09-03-2017 IPR011611 Carbohydrate kinase PfkB TK78_RS03830 364f9c8c76ea8ebb839181ad08dfc5dd 307 Hamap MF_01987 Ribokinase [rbsK]. 10 307 24.763 T 09-03-2017 IPR011877 Ribokinase GO:0004747|GO:0006014 KEGG: 00030+2.7.1.15 TK78_RS03830 364f9c8c76ea8ebb839181ad08dfc5dd 307 SUPERFAMILY SSF53613 10 306 2.65E-74 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS03830 364f9c8c76ea8ebb839181ad08dfc5dd 307 ProSitePatterns PS00584 pfkB family of carbohydrate kinases signature 2. 252 265 - T 09-03-2017 IPR002173 Carbohydrate/puine kinase, PfkB, conserved site GO:0016773 TK78_RS03830 364f9c8c76ea8ebb839181ad08dfc5dd 307 PRINTS PR00990 Ribokinase signature 41 60 6.4E-33 T 09-03-2017 IPR002139 Ribokinase/fructokinase GO:0004747|GO:0006014 TK78_RS03830 364f9c8c76ea8ebb839181ad08dfc5dd 307 PRINTS PR00990 Ribokinase signature 179 194 6.4E-33 T 09-03-2017 IPR002139 Ribokinase/fructokinase GO:0004747|GO:0006014 TK78_RS03830 364f9c8c76ea8ebb839181ad08dfc5dd 307 PRINTS PR00990 Ribokinase signature 221 232 6.4E-33 T 09-03-2017 IPR002139 Ribokinase/fructokinase GO:0004747|GO:0006014 TK78_RS03830 364f9c8c76ea8ebb839181ad08dfc5dd 307 PRINTS PR00990 Ribokinase signature 14 35 6.4E-33 T 09-03-2017 IPR002139 Ribokinase/fructokinase GO:0004747|GO:0006014 TK78_RS03830 364f9c8c76ea8ebb839181ad08dfc5dd 307 PRINTS PR00990 Ribokinase signature 112 125 6.4E-33 T 09-03-2017 IPR002139 Ribokinase/fructokinase GO:0004747|GO:0006014 TK78_RS28765 cba59f70fbac6ee571286e152dafb7c8 321 Pfam PF13280 WYL domain 143 313 1.6E-32 T 09-03-2017 IPR026881 WYL domain TK78_RS28765 cba59f70fbac6ee571286e152dafb7c8 321 SMART SM00420 7 63 0.0061 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS28765 cba59f70fbac6ee571286e152dafb7c8 321 SUPERFAMILY SSF46785 4 62 1.11E-11 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS28765 cba59f70fbac6ee571286e152dafb7c8 321 Pfam PF08279 HTH domain 7 62 9.7E-16 T 09-03-2017 IPR013196 Helix-turn-helix, type 11 TK78_RS28765 cba59f70fbac6ee571286e152dafb7c8 321 Gene3D G3DSA:1.10.10.10 1 64 6.8E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS28765 cba59f70fbac6ee571286e152dafb7c8 321 ProSitePatterns PS00894 DeoR-type HTH domain signature. 7 41 - T 09-03-2017 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 TK78_RS22915 97010bb524ff80b89869f0cd20564d40 256 Pfam PF02096 60Kd inner membrane protein 30 242 1.4E-35 T 09-03-2017 IPR001708 Membrane insertase OXA1/ALB3/YidC GO:0016021|GO:0051205 TK78_RS22915 97010bb524ff80b89869f0cd20564d40 256 TIGRFAM TIGR03592 yidC_oxa1_cterm: membrane protein insertase, YidC/Oxa1 family 29 242 9.2E-38 T 09-03-2017 IPR028055 Membrane insertase YidC/Oxa1, C-terminal TK78_RS24015 c48e4069214d205e9e4569933f9a0229 399 Gene3D G3DSA:3.30.565.10 292 389 2.4E-7 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS24015 c48e4069214d205e9e4569933f9a0229 399 SUPERFAMILY SSF55874 276 387 2.44E-15 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS24015 c48e4069214d205e9e4569933f9a0229 399 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 298 388 3.9E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS24015 c48e4069214d205e9e4569933f9a0229 399 SMART SM00387 294 389 0.0019 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS24015 c48e4069214d205e9e4569933f9a0229 399 Pfam PF07730 Histidine kinase 189 254 2.2E-15 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS19965 d15ffaf124e5100a984e4f88367700f0 70 TIGRFAM TIGR01764 excise: DNA binding domain, excisionase family 14 61 6.3E-21 T 09-03-2017 IPR010093 SinI-like, DNA-binding domain GO:0003677 TK78_RS19965 d15ffaf124e5100a984e4f88367700f0 70 Pfam PF12728 Helix-turn-helix domain 14 62 7.5E-14 T 09-03-2017 TK78_RS19965 d15ffaf124e5100a984e4f88367700f0 70 Gene3D G3DSA:1.10.10.10 14 62 3.0E-4 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS19965 d15ffaf124e5100a984e4f88367700f0 70 SUPERFAMILY SSF46955 13 63 9.34E-6 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS27645 2710f4b7790839be4b92647966aafbf2 286 Pfam PF13803 Domain of unknown function (DUF4184) 1 258 2.3E-53 T 09-03-2017 IPR025238 Protein of unknown function DUF4184 TK78_RS04395 257d944836f2092ccf6804f3de0d18cf 490 Gene3D G3DSA:1.10.10.60 83 137 5.5E-4 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS04395 257d944836f2092ccf6804f3de0d18cf 490 Gene3D G3DSA:1.10.1670.10 433 486 2.9E-18 T 09-03-2017 IPR023170 Helix-turn-helix, base-excision DNA repair, C-terminal Reactome: R-HSA-110357 TK78_RS04395 257d944836f2092ccf6804f3de0d18cf 490 Pfam PF02805 Metal binding domain of Ada 8 71 1.7E-25 T 09-03-2017 IPR004026 Ada DNA repair, metal-binding GO:0003677|GO:0006281|GO:0006355|GO:0008168|GO:0008270 TK78_RS04395 257d944836f2092ccf6804f3de0d18cf 490 Gene3D G3DSA:3.30.310.20 201 315 1.4E-33 T 09-03-2017 IPR010316 DNA-3-methyladenine glycosylase AlkA, N-terminal TK78_RS04395 257d944836f2092ccf6804f3de0d18cf 490 Gene3D G3DSA:1.10.10.60 138 186 5.0E-8 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS04395 257d944836f2092ccf6804f3de0d18cf 490 Pfam PF00730 HhH-GPD superfamily base excision DNA repair protein 321 464 6.1E-7 T 09-03-2017 IPR003265 HhH-GPD domain GO:0006284 Reactome: R-HSA-110357 TK78_RS04395 257d944836f2092ccf6804f3de0d18cf 490 SMART SM00342 100 183 9.8E-17 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS04395 257d944836f2092ccf6804f3de0d18cf 490 Gene3D G3DSA:3.40.10.10 2 82 8.4E-32 T 09-03-2017 IPR004026 Ada DNA repair, metal-binding GO:0003677|GO:0006281|GO:0006355|GO:0008168|GO:0008270 TK78_RS04395 257d944836f2092ccf6804f3de0d18cf 490 SMART SM00478 325 482 5.1E-31 T 09-03-2017 IPR003265 HhH-GPD domain GO:0006284 Reactome: R-HSA-110357 TK78_RS04395 257d944836f2092ccf6804f3de0d18cf 490 SUPERFAMILY SSF55945 201 296 1.73E-25 T 09-03-2017 TK78_RS04395 257d944836f2092ccf6804f3de0d18cf 490 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 137 179 - T 09-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 TK78_RS04395 257d944836f2092ccf6804f3de0d18cf 490 SMART SM01009 200 315 1.1E-45 T 09-03-2017 IPR010316 DNA-3-methyladenine glycosylase AlkA, N-terminal TK78_RS04395 257d944836f2092ccf6804f3de0d18cf 490 Gene3D G3DSA:1.10.340.30 318 432 7.2E-33 T 09-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 TK78_RS04395 257d944836f2092ccf6804f3de0d18cf 490 SUPERFAMILY SSF48150 306 481 4.36E-39 T 09-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 TK78_RS04395 257d944836f2092ccf6804f3de0d18cf 490 SUPERFAMILY SSF46689 137 186 2.33E-6 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS04395 257d944836f2092ccf6804f3de0d18cf 490 SUPERFAMILY SSF57884 2 82 2.75E-29 T 09-03-2017 IPR004026 Ada DNA repair, metal-binding GO:0003677|GO:0006281|GO:0006355|GO:0008168|GO:0008270 TK78_RS04395 257d944836f2092ccf6804f3de0d18cf 490 Pfam PF06029 AlkA N-terminal domain 201 315 3.3E-30 T 09-03-2017 IPR010316 DNA-3-methyladenine glycosylase AlkA, N-terminal TK78_RS04395 257d944836f2092ccf6804f3de0d18cf 490 Pfam PF12833 Helix-turn-helix domain 106 185 5.2E-16 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS19555 83cc5cbb319f8b5c8bd60c7dbf2d1761 333 Gene3D G3DSA:3.40.50.300 3 227 4.3E-67 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS19555 83cc5cbb319f8b5c8bd60c7dbf2d1761 333 ProSitePatterns PS00211 ABC transporters family signature. 136 150 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS19555 83cc5cbb319f8b5c8bd60c7dbf2d1761 333 SMART SM00382 29 212 6.5E-7 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS19555 83cc5cbb319f8b5c8bd60c7dbf2d1761 333 SUPERFAMILY SSF52540 5 225 6.03E-59 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS19555 83cc5cbb319f8b5c8bd60c7dbf2d1761 333 Pfam PF00005 ABC transporter 20 163 1.4E-25 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS19555 83cc5cbb319f8b5c8bd60c7dbf2d1761 333 TIGRFAM TIGR01188 drrA: daunorubicin resistance ABC transporter, ATP-binding protein 12 306 4.4E-103 T 09-03-2017 IPR005894 Daunorubicin resistance ABC transporter ATP-binding subunit DrrA GO:0005524|GO:0043215|GO:1900753 TK78_RS22885 9510b2c0eee0b91137aa7ed308775e29 278 Gene3D G3DSA:1.10.10.10 159 266 8.1E-15 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS22885 9510b2c0eee0b91137aa7ed308775e29 278 Gene3D G3DSA:3.40.600.10 9 158 1.8E-36 T 09-03-2017 IPR011337 DNA mismatch repair MutH/Restriction endonuclease, type II GO:0003677|GO:0004519 TK78_RS22885 9510b2c0eee0b91137aa7ed308775e29 278 SUPERFAMILY SSF52980 12 264 2.73E-24 T 09-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 TK78_RS22885 9510b2c0eee0b91137aa7ed308775e29 278 Pfam PF09126 Restriction endonuclease NaeI 9 262 2.6E-36 T 09-03-2017 IPR015210 Type-2 restriction enzyme NaeI GO:0009036|GO:0009307 TK78_RS29455 98d60119c92a46f3978cda4c7536a0f6 421 Gene3D G3DSA:3.40.50.150 137 416 5.0E-94 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS29455 98d60119c92a46f3978cda4c7536a0f6 421 SUPERFAMILY SSF53335 148 417 1.99E-66 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS29455 98d60119c92a46f3978cda4c7536a0f6 421 PIRSF PIRSF003085 51 421 1.0E-118 T 09-03-2017 IPR003333 Mycolic acid cyclopropane synthase GO:0008610 TK78_RS29455 98d60119c92a46f3978cda4c7536a0f6 421 Pfam PF02353 Mycolic acid cyclopropane synthetase 144 413 1.4E-85 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS20680 a3f76139f09ff47afd4c684a521e8675 66 Pfam PF02342 TerD domain 3 61 1.1E-8 T 09-03-2017 IPR003325 TerD domain GO:0006950 TK78_RS20680 a3f76139f09ff47afd4c684a521e8675 66 Gene3D G3DSA:2.60.60.30 1 59 1.1E-9 T 09-03-2017 TK78_RS14565 fef1e41c9bc1eeb0f6f23cb88cf8c823 317 PIRSF PIRSF035875 21 315 1.9E-44 T 09-03-2017 IPR017039 Virulence factor BrkB TK78_RS14565 fef1e41c9bc1eeb0f6f23cb88cf8c823 317 TIGRFAM TIGR00765 yihY_not_rbn: YihY family inner membrane protein 40 301 1.3E-22 T 09-03-2017 IPR017039 Virulence factor BrkB TK78_RS14565 fef1e41c9bc1eeb0f6f23cb88cf8c823 317 Pfam PF03631 Virulence factor BrkB 46 303 2.1E-39 T 09-03-2017 IPR017039 Virulence factor BrkB TK78_RS18075 8cd3777833c8545f4fcbcd71438e0978 363 Pfam PF04303 PrpF protein 49 306 1.1E-19 T 09-03-2017 IPR007400 PrpF protein TK78_RS18075 8cd3777833c8545f4fcbcd71438e0978 363 SUPERFAMILY SSF54506 151 309 4.32E-27 T 09-03-2017 TK78_RS18075 8cd3777833c8545f4fcbcd71438e0978 363 Gene3D G3DSA:3.10.310.10 49 127 1.4E-7 T 09-03-2017 TK78_RS18075 8cd3777833c8545f4fcbcd71438e0978 363 SUPERFAMILY SSF54506 44 134 1.73E-13 T 09-03-2017 TK78_RS18075 8cd3777833c8545f4fcbcd71438e0978 363 Gene3D G3DSA:3.10.310.10 151 305 1.3E-22 T 09-03-2017 TK78_RS09440 c08b14a1959655859b178cff44ae0888 632 Gene3D G3DSA:3.20.20.80 46 428 9.2E-72 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS09440 c08b14a1959655859b178cff44ae0888 632 Pfam PF00150 Cellulase (glycosyl hydrolase family 5) 108 399 8.9E-30 T 09-03-2017 IPR001547 Glycoside hydrolase, family 5 GO:0004553|GO:0005975 TK78_RS09440 c08b14a1959655859b178cff44ae0888 632 SUPERFAMILY SSF51445 361 421 8.02E-45 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS09440 c08b14a1959655859b178cff44ae0888 632 SUPERFAMILY SSF51445 48 326 8.02E-45 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS10185 a8eacf1fcb47f3a405a7a8339d7427f8 118 Gene3D G3DSA:1.10.10.10 4 76 1.5E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS10185 a8eacf1fcb47f3a405a7a8339d7427f8 118 Pfam PF00392 Bacterial regulatory proteins, gntR family 14 76 4.0E-15 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS10185 a8eacf1fcb47f3a405a7a8339d7427f8 118 SMART SM00345 17 76 7.6E-12 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS10185 a8eacf1fcb47f3a405a7a8339d7427f8 118 SUPERFAMILY SSF46785 6 80 5.44E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS25175 65951fcb1c6a8d785920375a69c4bef1 119 Pfam PF13806 Rieske-like [2Fe-2S] domain 23 118 3.8E-31 T 09-03-2017 IPR012748 Nitrite reductase [NAD(P)H] small subunit, NirD GO:0008942|GO:0042128|GO:0055114 TK78_RS25175 65951fcb1c6a8d785920375a69c4bef1 119 Gene3D G3DSA:2.102.10.10 22 118 5.2E-33 T 09-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 TK78_RS25175 65951fcb1c6a8d785920375a69c4bef1 119 SUPERFAMILY SSF50022 22 118 7.14E-28 T 09-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 TK78_RS25175 65951fcb1c6a8d785920375a69c4bef1 119 TIGRFAM TIGR02378 nirD_assim_sml: nitrite reductase [NAD(P)H], small subunit 23 118 1.1E-24 T 09-03-2017 IPR012748 Nitrite reductase [NAD(P)H] small subunit, NirD GO:0008942|GO:0042128|GO:0055114 TK78_RS26080 ca2b6ae140977c9d7805d804dfb2e61f 159 Pfam PF00932 Lamin Tail Domain 34 147 1.9E-16 T 09-03-2017 IPR001322 Lamin Tail Domain TK78_RS26080 ca2b6ae140977c9d7805d804dfb2e61f 159 Gene3D G3DSA:2.60.40.1260 56 150 6.7E-13 T 09-03-2017 IPR001322 Lamin Tail Domain TK78_RS26080 ca2b6ae140977c9d7805d804dfb2e61f 159 SUPERFAMILY SSF74853 56 148 2.22E-16 T 09-03-2017 IPR001322 Lamin Tail Domain TK78_RS09615 ad81c836b65cb5a3f5d2c8b0329c7067 282 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 4 183 3.8E-69 T 09-03-2017 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS09615 ad81c836b65cb5a3f5d2c8b0329c7067 282 Gene3D G3DSA:3.40.50.720 3 187 3.7E-65 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS09615 ad81c836b65cb5a3f5d2c8b0329c7067 282 PIRSF PIRSF000105 1 282 2.7E-91 T 09-03-2017 IPR022694 3-hydroxyacyl-CoA dehydrogenase GO:0003857|GO:0006631|GO:0055114|GO:0070403 TK78_RS09615 ad81c836b65cb5a3f5d2c8b0329c7067 282 Gene3D G3DSA:1.10.1040.10 188 282 1.6E-29 T 09-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 TK78_RS09615 ad81c836b65cb5a3f5d2c8b0329c7067 282 ProSitePatterns PS00067 3-hydroxyacyl-CoA dehydrogenase signature. 183 208 - T 09-03-2017 IPR006180 3-hydroxyacyl-CoA dehydrogenase, conserved site GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+5.1.2.3+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+5.1.2.3+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS09615 ad81c836b65cb5a3f5d2c8b0329c7067 282 SUPERFAMILY SSF48179 186 282 1.11E-26 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS09615 ad81c836b65cb5a3f5d2c8b0329c7067 282 SUPERFAMILY SSF51735 3 182 3.85E-62 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS09615 ad81c836b65cb5a3f5d2c8b0329c7067 282 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 186 282 1.5E-29 T 09-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS32970 85a97157c7e5fe511003d75bc00698d8 353 Gene3D G3DSA:3.20.20.70 18 335 1.9E-45 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS32970 85a97157c7e5fe511003d75bc00698d8 353 SUPERFAMILY SSF51569 18 333 3.56E-29 T 09-03-2017 TK78_RS32970 85a97157c7e5fe511003d75bc00698d8 353 SMART SM01130 14 335 1.2E-8 T 09-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 TK78_RS20090 8c5924e16f8cedac43797693bf83af42 277 SUPERFAMILY SSF46955 13 121 8.42E-28 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS20090 8c5924e16f8cedac43797693bf83af42 277 SMART SM00422 13 82 5.7E-21 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS20090 8c5924e16f8cedac43797693bf83af42 277 Pfam PF07739 TipAS antibiotic-recognition domain 144 255 1.2E-28 T 09-03-2017 IPR012925 TipAS antibiotic-recognition domain TK78_RS20090 8c5924e16f8cedac43797693bf83af42 277 Pfam PF13411 MerR HTH family regulatory protein 14 80 3.9E-13 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS20090 8c5924e16f8cedac43797693bf83af42 277 Gene3D G3DSA:1.10.1660.10 13 121 4.0E-29 T 09-03-2017 TK78_RS20090 8c5924e16f8cedac43797693bf83af42 277 Gene3D G3DSA:1.10.490.50 170 260 2.3E-26 T 09-03-2017 IPR012925 TipAS antibiotic-recognition domain TK78_RS20090 8c5924e16f8cedac43797693bf83af42 277 SUPERFAMILY SSF89082 170 261 2.22E-20 T 09-03-2017 IPR012925 TipAS antibiotic-recognition domain TK78_RS32290 455f521c97d834fcdeb8342ae7a0b6b9 264 Pfam PF04542 Sigma-70 region 2 45 110 2.0E-17 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS32290 455f521c97d834fcdeb8342ae7a0b6b9 264 SUPERFAMILY SSF88946 34 110 6.8E-26 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS32290 455f521c97d834fcdeb8342ae7a0b6b9 264 PRINTS PR00046 Major sigma-70 factor signature 212 224 1.9E-5 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS32290 455f521c97d834fcdeb8342ae7a0b6b9 264 PRINTS PR00046 Major sigma-70 factor signature 229 244 1.9E-5 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS32290 455f521c97d834fcdeb8342ae7a0b6b9 264 PRINTS PR00046 Major sigma-70 factor signature 65 78 1.9E-5 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS32290 455f521c97d834fcdeb8342ae7a0b6b9 264 Gene3D G3DSA:1.10.601.10 36 108 7.7E-19 T 09-03-2017 TK78_RS32290 455f521c97d834fcdeb8342ae7a0b6b9 264 Pfam PF04539 Sigma-70 region 3 121 176 2.6E-6 T 09-03-2017 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS32290 455f521c97d834fcdeb8342ae7a0b6b9 264 Gene3D G3DSA:1.10.10.10 109 164 4.9E-16 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32290 455f521c97d834fcdeb8342ae7a0b6b9 264 SUPERFAMILY SSF88659 184 257 2.06E-13 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS32290 455f521c97d834fcdeb8342ae7a0b6b9 264 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 38 257 6.2E-31 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS32290 455f521c97d834fcdeb8342ae7a0b6b9 264 TIGRFAM TIGR02980 SigBFG: RNA polymerase sigma-70 factor, sigma-B/F/G subfamily 35 258 4.3E-81 T 09-03-2017 IPR014322 RNA polymerase sigma-B/F/G type GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS32290 455f521c97d834fcdeb8342ae7a0b6b9 264 Gene3D G3DSA:1.10.10.10 206 257 1.1E-9 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32290 455f521c97d834fcdeb8342ae7a0b6b9 264 SUPERFAMILY SSF88659 114 189 8.72E-9 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS32290 455f521c97d834fcdeb8342ae7a0b6b9 264 Pfam PF04545 Sigma-70, region 4 209 257 1.5E-16 T 09-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS16500 8b801284c882af59625ede15c5bc1568 217 TIGRFAM TIGR03252 TIGR03252: uncharacterized HhH-GPD family protein 11 200 1.1E-93 T 09-03-2017 IPR017658 Conserved hypothetical protein CHP03252, HhH-GPD TK78_RS16500 8b801284c882af59625ede15c5bc1568 217 Pfam PF00730 HhH-GPD superfamily base excision DNA repair protein 33 191 1.5E-11 T 09-03-2017 IPR003265 HhH-GPD domain GO:0006284 Reactome: R-HSA-110357 TK78_RS16500 8b801284c882af59625ede15c5bc1568 217 SUPERFAMILY SSF48150 18 149 9.42E-13 T 09-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 TK78_RS16500 8b801284c882af59625ede15c5bc1568 217 Gene3D G3DSA:1.10.340.30 23 144 9.3E-10 T 09-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 TK78_RS32730 903a3a62cea51858b4961c05ba4cd38e 306 Gene3D G3DSA:2.120.10.30 52 95 9.2E-5 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS32730 903a3a62cea51858b4961c05ba4cd38e 306 Gene3D G3DSA:2.120.10.30 96 299 5.1E-54 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS32730 903a3a62cea51858b4961c05ba4cd38e 306 SUPERFAMILY SSF101898 50 235 1.99E-42 T 09-03-2017 TK78_RS32730 903a3a62cea51858b4961c05ba4cd38e 306 SUPERFAMILY SSF50956 206 299 9.42E-14 T 09-03-2017 TK78_RS32730 903a3a62cea51858b4961c05ba4cd38e 306 Pfam PF01436 NHL repeat 84 107 1.7E-4 T 09-03-2017 IPR001258 NHL repeat GO:0005515 TK78_RS32730 903a3a62cea51858b4961c05ba4cd38e 306 Pfam PF08450 SMP-30/Gluconolaconase/LRE-like region 123 224 1.9E-7 T 09-03-2017 IPR013658 SMP-30/Gluconolactonase/LRE-like region TK78_RS07920 c49e1abf91c6e8f99ac161f0e4503537 608 Gene3D G3DSA:2.60.120.260 41 172 1.1E-13 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS07920 c49e1abf91c6e8f99ac161f0e4503537 608 Gene3D G3DSA:3.20.20.80 271 600 6.2E-65 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS07920 c49e1abf91c6e8f99ac161f0e4503537 608 SUPERFAMILY SSF49265 177 261 7.22E-18 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS07920 c49e1abf91c6e8f99ac161f0e4503537 608 Gene3D G3DSA:2.60.40.10 179 258 3.8E-20 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS07920 c49e1abf91c6e8f99ac161f0e4503537 608 ProSitePatterns PS01095 Chitinases family 18 active site. 386 394 - T 09-03-2017 IPR001579 Glycoside hydrolase, chitinase active site GO:0004553|GO:0005975 KEGG: 00520+3.2.1.14|MetaCyc: PWY-6902 TK78_RS07920 c49e1abf91c6e8f99ac161f0e4503537 608 SMART SM00060 179 249 3.1E-13 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS07920 c49e1abf91c6e8f99ac161f0e4503537 608 SUPERFAMILY SSF51445 276 599 2.66E-56 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS07920 c49e1abf91c6e8f99ac161f0e4503537 608 Pfam PF00041 Fibronectin type III domain 182 252 4.2E-7 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS07920 c49e1abf91c6e8f99ac161f0e4503537 608 SUPERFAMILY SSF49785 39 171 1.63E-12 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS07920 c49e1abf91c6e8f99ac161f0e4503537 608 Pfam PF02018 Carbohydrate binding domain 40 155 4.3E-18 T 09-03-2017 IPR003305 Carbohydrate-binding, CenC-like GO:0016798 TK78_RS07920 c49e1abf91c6e8f99ac161f0e4503537 608 SMART SM00636 274 591 1.3E-6 T 09-03-2017 IPR011583 Chitinase II GO:0004568|GO:0006032 TK78_RS07920 c49e1abf91c6e8f99ac161f0e4503537 608 Pfam PF00704 Glycosyl hydrolases family 18 276 591 9.3E-25 T 09-03-2017 IPR001223 Glycoside hydrolase family 18, catalytic domain GO:0004553|GO:0005975 TK78_RS26850 35b48759609eeeff8532955d1160dd41 380 SUPERFAMILY SSF53756 5 379 8.72E-77 T 09-03-2017 TK78_RS26850 35b48759609eeeff8532955d1160dd41 380 Gene3D G3DSA:3.40.50.2000 168 361 4.4E-36 T 09-03-2017 TK78_RS26850 35b48759609eeeff8532955d1160dd41 380 Pfam PF00534 Glycosyl transferases group 1 195 362 6.5E-43 T 09-03-2017 IPR001296 Glycosyl transferase, family 1 TK78_RS26850 35b48759609eeeff8532955d1160dd41 380 Pfam PF13439 Glycosyltransferase Family 4 16 178 2.5E-8 T 09-03-2017 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 TK78_RS00760 f67d6d7a60a4b0bc9643631da90aeacb 223 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 14 27 1.3E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS00760 f67d6d7a60a4b0bc9643631da90aeacb 223 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 35 58 1.3E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS00760 f67d6d7a60a4b0bc9643631da90aeacb 223 Gene3D G3DSA:1.10.357.10 3 196 1.6E-44 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS00760 f67d6d7a60a4b0bc9643631da90aeacb 223 SUPERFAMILY SSF46689 3 76 2.92E-18 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS00760 f67d6d7a60a4b0bc9643631da90aeacb 223 SUPERFAMILY SSF48498 84 194 6.68E-19 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS00760 f67d6d7a60a4b0bc9643631da90aeacb 223 Pfam PF13977 Bacterial transcriptional repressor 86 196 2.0E-12 T 09-03-2017 TK78_RS00760 f67d6d7a60a4b0bc9643631da90aeacb 223 Pfam PF00440 Bacterial regulatory proteins, tetR family 14 60 1.8E-15 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS31545 d7c6cdfe9bb5d8ebf5408816ebd87422 418 TIGRFAM TIGR00433 bioB: biotin synthase 28 321 2.4E-113 T 09-03-2017 IPR002684 Biotin synthase/Biotin biosynthesis bifunctional protein BioAB GO:0004076|GO:0009102 KEGG: 00780+2.8.1.6|MetaCyc: PWY-7380 TK78_RS31545 d7c6cdfe9bb5d8ebf5408816ebd87422 418 Hamap MF_01694 Biotin synthase [bioB]. 15 323 39.437 T 09-03-2017 IPR002684 Biotin synthase/Biotin biosynthesis bifunctional protein BioAB GO:0004076|GO:0009102 KEGG: 00780+2.8.1.6|MetaCyc: PWY-7380 TK78_RS31545 d7c6cdfe9bb5d8ebf5408816ebd87422 418 Pfam PF04055 Radical SAM superfamily 65 220 9.1E-13 T 09-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 TK78_RS31545 d7c6cdfe9bb5d8ebf5408816ebd87422 418 SUPERFAMILY SSF102114 18 321 4.71E-77 T 09-03-2017 TK78_RS31545 d7c6cdfe9bb5d8ebf5408816ebd87422 418 SMART SM00729 55 261 1.1E-38 T 09-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 TK78_RS31545 d7c6cdfe9bb5d8ebf5408816ebd87422 418 Pfam PF06968 Biotin and Thiamin Synthesis associated domain 232 321 3.7E-14 T 09-03-2017 IPR010722 Biotin and thiamin synthesis-associated domain KEGG: 00780+2.8.1.6|MetaCyc: PWY-7380 TK78_RS31545 d7c6cdfe9bb5d8ebf5408816ebd87422 418 Gene3D G3DSA:3.20.20.70 17 322 1.3E-87 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS31545 d7c6cdfe9bb5d8ebf5408816ebd87422 418 SMART SM00876 232 322 3.3E-32 T 09-03-2017 IPR010722 Biotin and thiamin synthesis-associated domain KEGG: 00780+2.8.1.6|MetaCyc: PWY-7380 TK78_RS09245 3bb2f6632acffd742db995dc7d8ce9d8 255 SUPERFAMILY SSF52096 2 253 2.34E-83 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS09245 3bb2f6632acffd742db995dc7d8ce9d8 255 Gene3D G3DSA:3.90.226.10 2 247 4.2E-87 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS09245 3bb2f6632acffd742db995dc7d8ce9d8 255 ProSitePatterns PS00166 Enoyl-CoA hydratase/isomerase signature. 96 116 - T 09-03-2017 IPR018376 Enoyl-CoA hydratase/isomerase, conserved site GO:0003824|GO:0008152 TK78_RS09245 3bb2f6632acffd742db995dc7d8ce9d8 255 Pfam PF00378 Enoyl-CoA hydratase/isomerase 8 248 7.2E-71 T 09-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 TK78_RS14225 368987f68a2f9bc400307aa54a994cc8 582 Pfam PF07287 Protein of unknown function (DUF1446) 15 349 1.2E-121 T 09-03-2017 IPR010839 Protein of unknown function DUF1446 TK78_RS33755 77a3f5f5583e0c6a710961d441274f0c 292 PIRSF PIRSF037395 17 276 1.2E-88 T 09-03-2017 IPR017196 ECF transporter, predicted substrate-specific component UCP037395 TK78_RS33755 77a3f5f5583e0c6a710961d441274f0c 292 Pfam PF12822 Protein of unknown function (DUF3816) 86 251 1.9E-17 T 09-03-2017 IPR024529 ECF transporter, substrate-specific component GO:0005215 TK78_RS01525 682a50a4f91119fa530e605838f2b69e 637 TIGRFAM TIGR03604 TOMM_cyclo_SagD: thiazole/oxazole-forming peptide maturase, SagD family component 244 637 5.4E-78 T 09-03-2017 IPR027624 Thiazole/oxazole-forming peptide maturase, SagD family component TK78_RS01525 682a50a4f91119fa530e605838f2b69e 637 TIGRFAM TIGR03882 cyclo_dehyd_2: bacteriocin biosynthesis cyclodehydratase domain 58 214 5.8E-19 T 09-03-2017 IPR022291 Bacteriocin biosynthesis, cyclodehydratase domain TK78_RS01525 682a50a4f91119fa530e605838f2b69e 637 Pfam PF02624 YcaO cyclodehydratase, ATP-ad Mg2+-binding 243 591 1.5E-75 T 09-03-2017 IPR003776 YcaO-like domain TK78_RS08285 807b81e1332bab1ccb5716bde29ad2f2 169 TIGRFAM TIGR00125 cyt_tran_rel: cytidyltransferase-like domain 13 70 6.7E-15 T 09-03-2017 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 TK78_RS08285 807b81e1332bab1ccb5716bde29ad2f2 169 SUPERFAMILY SSF52374 12 165 2.95E-45 T 09-03-2017 TK78_RS08285 807b81e1332bab1ccb5716bde29ad2f2 169 Gene3D G3DSA:3.40.50.620 12 165 5.7E-52 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS08285 807b81e1332bab1ccb5716bde29ad2f2 169 TIGRFAM TIGR01510 coaD_prev_kdtB: pantetheine-phosphate adenylyltransferase 13 164 1.6E-58 T 09-03-2017 IPR001980 Coenzyme A biosynthesis protein GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3 TK78_RS08285 807b81e1332bab1ccb5716bde29ad2f2 169 Pfam PF01467 Cytidylyltransferase-like 16 142 8.2E-18 T 09-03-2017 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 TK78_RS08285 807b81e1332bab1ccb5716bde29ad2f2 169 PRINTS PR01020 Lipopolysaccharide core biosynthesis protein signature 12 30 3.3E-50 T 09-03-2017 IPR001980 Coenzyme A biosynthesis protein GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3 TK78_RS08285 807b81e1332bab1ccb5716bde29ad2f2 169 PRINTS PR01020 Lipopolysaccharide core biosynthesis protein signature 30 51 3.3E-50 T 09-03-2017 IPR001980 Coenzyme A biosynthesis protein GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3 TK78_RS08285 807b81e1332bab1ccb5716bde29ad2f2 169 PRINTS PR01020 Lipopolysaccharide core biosynthesis protein signature 121 143 3.3E-50 T 09-03-2017 IPR001980 Coenzyme A biosynthesis protein GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3 TK78_RS08285 807b81e1332bab1ccb5716bde29ad2f2 169 PRINTS PR01020 Lipopolysaccharide core biosynthesis protein signature 59 83 3.3E-50 T 09-03-2017 IPR001980 Coenzyme A biosynthesis protein GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3 TK78_RS08285 807b81e1332bab1ccb5716bde29ad2f2 169 PRINTS PR01020 Lipopolysaccharide core biosynthesis protein signature 95 111 3.3E-50 T 09-03-2017 IPR001980 Coenzyme A biosynthesis protein GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3 TK78_RS08285 807b81e1332bab1ccb5716bde29ad2f2 169 ProDom PD016147 LIGASE LYASE CITRATE PRO-3S-LYASE SYNTHETASE TRANSFERASE CYTIDYLTRANSFERASE-RELATED:CITRATE ACETATE:SH-CITRATE CITC PLASMID 21 165 7.0E-5 T 09-03-2017 TK78_RS08285 807b81e1332bab1ccb5716bde29ad2f2 169 Hamap MF_00151 Phosphopantetheine adenylyltransferase [coaD]. 12 167 34.509 T 09-03-2017 IPR001980 Coenzyme A biosynthesis protein GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3 TK78_RS04410 226d1569e9617c12ba93d68f71ad2428 281 Gene3D G3DSA:3.30.540.10 20 174 6.6E-37 T 09-03-2017 TK78_RS04410 226d1569e9617c12ba93d68f71ad2428 281 ProSitePatterns PS00629 Inositol monophosphatase family signature 1. 100 113 - T 09-03-2017 IPR020583 Inositol monophosphatase, metal-binding site TK78_RS04410 226d1569e9617c12ba93d68f71ad2428 281 PRINTS PR00377 Inositol monophosphatase superfamily signature 73 89 7.9E-22 T 09-03-2017 IPR000760 Inositol monophosphatase GO:0046854 TK78_RS04410 226d1569e9617c12ba93d68f71ad2428 281 PRINTS PR00377 Inositol monophosphatase superfamily signature 224 248 7.9E-22 T 09-03-2017 IPR000760 Inositol monophosphatase GO:0046854 TK78_RS04410 226d1569e9617c12ba93d68f71ad2428 281 PRINTS PR00377 Inositol monophosphatase superfamily signature 51 71 7.9E-22 T 09-03-2017 IPR000760 Inositol monophosphatase GO:0046854 TK78_RS04410 226d1569e9617c12ba93d68f71ad2428 281 PRINTS PR00377 Inositol monophosphatase superfamily signature 149 172 7.9E-22 T 09-03-2017 IPR000760 Inositol monophosphatase GO:0046854 TK78_RS04410 226d1569e9617c12ba93d68f71ad2428 281 PRINTS PR00377 Inositol monophosphatase superfamily signature 193 214 7.9E-22 T 09-03-2017 IPR000760 Inositol monophosphatase GO:0046854 TK78_RS04410 226d1569e9617c12ba93d68f71ad2428 281 PRINTS PR00377 Inositol monophosphatase superfamily signature 100 116 7.9E-22 T 09-03-2017 IPR000760 Inositol monophosphatase GO:0046854 TK78_RS04410 226d1569e9617c12ba93d68f71ad2428 281 ProSitePatterns PS00630 Inositol monophosphatase family signature 2. 227 241 - T 09-03-2017 IPR020550 Inositol monophosphatase, conserved site GO:0046854 TK78_RS04410 226d1569e9617c12ba93d68f71ad2428 281 SUPERFAMILY SSF56655 22 278 1.31E-59 T 09-03-2017 TK78_RS04410 226d1569e9617c12ba93d68f71ad2428 281 Gene3D G3DSA:3.40.190.80 175 278 5.1E-17 T 09-03-2017 TK78_RS04410 226d1569e9617c12ba93d68f71ad2428 281 Pfam PF00459 Inositol monophosphatase family 20 253 5.2E-56 T 09-03-2017 IPR000760 Inositol monophosphatase GO:0046854 TK78_RS29720 17f157b10cc91e7afdf24011cb0cb2b8 165 PRINTS PR00153 Cyclophilin peptidyl-prolyl cis-trans isomerase signature 123 138 9.1E-37 T 09-03-2017 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 TK78_RS29720 17f157b10cc91e7afdf24011cb0cb2b8 165 PRINTS PR00153 Cyclophilin peptidyl-prolyl cis-trans isomerase signature 95 110 9.1E-37 T 09-03-2017 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 TK78_RS29720 17f157b10cc91e7afdf24011cb0cb2b8 165 PRINTS PR00153 Cyclophilin peptidyl-prolyl cis-trans isomerase signature 23 38 9.1E-37 T 09-03-2017 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 TK78_RS29720 17f157b10cc91e7afdf24011cb0cb2b8 165 PRINTS PR00153 Cyclophilin peptidyl-prolyl cis-trans isomerase signature 52 64 9.1E-37 T 09-03-2017 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 TK78_RS29720 17f157b10cc91e7afdf24011cb0cb2b8 165 PRINTS PR00153 Cyclophilin peptidyl-prolyl cis-trans isomerase signature 110 122 9.1E-37 T 09-03-2017 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 TK78_RS29720 17f157b10cc91e7afdf24011cb0cb2b8 165 Pfam PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD 6 163 7.4E-45 T 09-03-2017 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 TK78_RS29720 17f157b10cc91e7afdf24011cb0cb2b8 165 Gene3D G3DSA:2.40.100.10 2 165 3.7E-71 T 09-03-2017 IPR029000 Cyclophilin-like domain TK78_RS29720 17f157b10cc91e7afdf24011cb0cb2b8 165 PIRSF PIRSF001467 1 165 8.1E-76 T 09-03-2017 IPR024936 Cyclophilin-type peptidyl-prolyl cis-trans isomerase GO:0003755|GO:0006457 TK78_RS29720 17f157b10cc91e7afdf24011cb0cb2b8 165 SUPERFAMILY SSF50891 2 165 5.7E-68 T 09-03-2017 IPR029000 Cyclophilin-like domain TK78_RS29720 17f157b10cc91e7afdf24011cb0cb2b8 165 ProSitePatterns PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 47 64 - T 09-03-2017 IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site GO:0003755|GO:0006457 TK78_RS21575 bc7d85a390fdcfaaa24c9952db93d518 426 Gene3D G3DSA:3.20.20.120 128 421 5.5E-138 T 09-03-2017 IPR029065 Enolase C-terminal domain-like TK78_RS21575 bc7d85a390fdcfaaa24c9952db93d518 426 Pfam PF03952 Enolase, N-terminal domain 4 134 2.4E-55 T 09-03-2017 IPR020811 Enolase, N-terminal KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS21575 bc7d85a390fdcfaaa24c9952db93d518 426 PIRSF PIRSF001400 2 422 1.6E-188 T 09-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS21575 bc7d85a390fdcfaaa24c9952db93d518 426 Hamap MF_00318 Enolase [eno]. 2 409 45.002 T 09-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS21575 bc7d85a390fdcfaaa24c9952db93d518 426 Pfam PF00113 Enolase, C-terminal TIM barrel domain 140 420 2.2E-133 T 09-03-2017 IPR020810 Enolase, C-terminal TIM barrel domain KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS21575 bc7d85a390fdcfaaa24c9952db93d518 426 SUPERFAMILY SSF51604 138 422 8.12E-132 T 09-03-2017 IPR029065 Enolase C-terminal domain-like TK78_RS21575 bc7d85a390fdcfaaa24c9952db93d518 426 SMART SM01193 4 134 4.6E-86 T 09-03-2017 IPR020811 Enolase, N-terminal KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS21575 bc7d85a390fdcfaaa24c9952db93d518 426 ProSitePatterns PS00164 Enolase signature. 332 345 - T 09-03-2017 IPR020809 Enolase, conserved site KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS21575 bc7d85a390fdcfaaa24c9952db93d518 426 TIGRFAM TIGR01060 eno: phosphopyruvate hydratase 4 423 2.3E-205 T 09-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS21575 bc7d85a390fdcfaaa24c9952db93d518 426 SUPERFAMILY SSF54826 4 138 1.06E-51 T 09-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS21575 bc7d85a390fdcfaaa24c9952db93d518 426 PRINTS PR00148 Enolase signature 361 378 5.6E-47 T 09-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS21575 bc7d85a390fdcfaaa24c9952db93d518 426 PRINTS PR00148 Enolase signature 309 320 5.6E-47 T 09-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS21575 bc7d85a390fdcfaaa24c9952db93d518 426 PRINTS PR00148 Enolase signature 332 346 5.6E-47 T 09-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS21575 bc7d85a390fdcfaaa24c9952db93d518 426 PRINTS PR00148 Enolase signature 161 174 5.6E-47 T 09-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS21575 bc7d85a390fdcfaaa24c9952db93d518 426 PRINTS PR00148 Enolase signature 107 123 5.6E-47 T 09-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS21575 bc7d85a390fdcfaaa24c9952db93d518 426 PRINTS PR00148 Enolase signature 37 51 5.6E-47 T 09-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS21575 bc7d85a390fdcfaaa24c9952db93d518 426 SMART SM01192 139 423 2.9E-228 T 09-03-2017 IPR020810 Enolase, C-terminal TIM barrel domain KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS21575 bc7d85a390fdcfaaa24c9952db93d518 426 Gene3D G3DSA:3.30.390.10 4 125 2.8E-52 T 09-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS32285 9e8693e24a68cc729354a0410bc51a5b 394 Pfam PF13823 Alcohol dehydrogenase GroES-associated 2 23 2.0E-10 T 09-03-2017 IPR027399 Alcohol dehydrogenase GroES-associated TK78_RS32285 9e8693e24a68cc729354a0410bc51a5b 394 Gene3D G3DSA:3.90.180.10 2 181 1.0E-48 T 09-03-2017 IPR011032 GroES-like TK78_RS32285 9e8693e24a68cc729354a0410bc51a5b 394 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 26 144 2.1E-27 T 09-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 TK78_RS32285 9e8693e24a68cc729354a0410bc51a5b 394 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 59 73 - T 09-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 TK78_RS32285 9e8693e24a68cc729354a0410bc51a5b 394 SUPERFAMILY SSF51735 156 354 2.22E-46 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS32285 9e8693e24a68cc729354a0410bc51a5b 394 Gene3D G3DSA:3.40.50.720 294 335 1.9E-33 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS32285 9e8693e24a68cc729354a0410bc51a5b 394 Gene3D G3DSA:3.40.50.720 182 259 1.9E-33 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS32285 9e8693e24a68cc729354a0410bc51a5b 394 Pfam PF00107 Zinc-binding dehydrogenase 189 259 4.9E-10 T 09-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 TK78_RS32285 9e8693e24a68cc729354a0410bc51a5b 394 SUPERFAMILY SSF50129 2 179 1.13E-55 T 09-03-2017 IPR011032 GroES-like TK78_RS08210 205fb8434df8e3e3f99ccf2183a48d09 215 Pfam PF09250 Bifunctional DNA primase/polymerase, N-terminal 29 198 1.6E-16 T 09-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal TK78_RS08210 205fb8434df8e3e3f99ccf2183a48d09 215 SMART SM00943 27 205 8.9E-35 T 09-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal TK78_RS08480 45a3e7937322af2e5115f250284c2cc6 1290 Pfam PF10633 NPCBM-associated, NEW3 domain of alpha-galactosidase 1045 1121 2.5E-17 T 09-03-2017 IPR018905 Alpha-galactosidase, NEW3 domain TK78_RS08480 45a3e7937322af2e5115f250284c2cc6 1290 Pfam PF12905 Endo-alpha-N-acetylgalactosaminidase 289 664 3.6E-153 T 09-03-2017 IPR025706 Endo-alpha-N-acetylgalactosaminidase GO:0033926 TK78_RS08480 45a3e7937322af2e5115f250284c2cc6 1290 Gene3D G3DSA:2.60.40.10 1031 1123 3.1E-10 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS08480 45a3e7937322af2e5115f250284c2cc6 1290 SMART SM00776 1143 1288 2.1E-65 T 09-03-2017 IPR013222 Glycosyl hydrolase family 98, putative carbohydrate-binding module TK78_RS08480 45a3e7937322af2e5115f250284c2cc6 1290 Pfam PF08305 NPCBM/NEW2 domain 1147 1286 1.9E-49 T 09-03-2017 IPR013222 Glycosyl hydrolase family 98, putative carbohydrate-binding module TK78_RS08480 45a3e7937322af2e5115f250284c2cc6 1290 SUPERFAMILY SSF49785 1147 1288 8.5E-46 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS21935 6d7e7d29a4cb4c01f6f61d429dbd417a 250 SUPERFAMILY SSF56801 5 248 5.76E-23 T 09-03-2017 TK78_RS21935 6d7e7d29a4cb4c01f6f61d429dbd417a 250 Pfam PF00501 AMP-binding enzyme 21 90 2.5E-5 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS21935 6d7e7d29a4cb4c01f6f61d429dbd417a 250 Gene3D G3DSA:3.40.50.980 7 90 4.6E-6 T 09-03-2017 TK78_RS21935 6d7e7d29a4cb4c01f6f61d429dbd417a 250 TIGRFAM TIGR03089 TIGR03089: TIGR03089 family protein 11 246 9.9E-83 T 09-03-2017 IPR017523 Conserved hypothetical protein CHP03089 TK78_RS21935 6d7e7d29a4cb4c01f6f61d429dbd417a 250 Gene3D G3DSA:3.40.50.980 169 248 1.7E-5 T 09-03-2017 TK78_RS12790 9ef95c79d71ec9e2158442bbc6df46d4 102 PRINTS PR00297 10kDa chaperonin signature 10 25 9.6E-31 T 09-03-2017 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 TK78_RS12790 9ef95c79d71ec9e2158442bbc6df46d4 102 PRINTS PR00297 10kDa chaperonin signature 66 78 9.6E-31 T 09-03-2017 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 TK78_RS12790 9ef95c79d71ec9e2158442bbc6df46d4 102 PRINTS PR00297 10kDa chaperonin signature 32 53 9.6E-31 T 09-03-2017 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 TK78_RS12790 9ef95c79d71ec9e2158442bbc6df46d4 102 PRINTS PR00297 10kDa chaperonin signature 87 100 9.6E-31 T 09-03-2017 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 TK78_RS12790 9ef95c79d71ec9e2158442bbc6df46d4 102 Gene3D G3DSA:2.30.33.40 10 101 5.3E-37 T 09-03-2017 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 TK78_RS12790 9ef95c79d71ec9e2158442bbc6df46d4 102 SUPERFAMILY SSF50129 9 101 8.59E-33 T 09-03-2017 IPR011032 GroES-like TK78_RS12790 9ef95c79d71ec9e2158442bbc6df46d4 102 Hamap MF_00580 10 kDa chaperonin [groS]. 9 101 25.513 T 09-03-2017 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 TK78_RS12790 9ef95c79d71ec9e2158442bbc6df46d4 102 Pfam PF00166 Chaperonin 10 Kd subunit 10 100 3.6E-33 T 09-03-2017 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 TK78_RS12790 9ef95c79d71ec9e2158442bbc6df46d4 102 ProSitePatterns PS00681 Chaperonins cpn10 signature. 10 34 - T 09-03-2017 IPR018369 Chaperonin GroES, conserved site GO:0005524|GO:0006457 TK78_RS12790 9ef95c79d71ec9e2158442bbc6df46d4 102 SMART SM00883 9 100 4.3E-52 T 09-03-2017 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 TK78_RS32735 5d8f8c2739e55dd0527812800c0d4d65 182 Pfam PF07336 Putative stress-induced transcription regulator 12 118 2.2E-8 T 09-03-2017 IPR010852 Putative stress-induced transcription regulator TK78_RS32735 5d8f8c2739e55dd0527812800c0d4d65 182 Gene3D G3DSA:1.10.3300.10 9 173 4.9E-32 T 09-03-2017 IPR023286 ABATE domain TK78_RS32735 5d8f8c2739e55dd0527812800c0d4d65 182 SUPERFAMILY SSF160904 5 173 1.06E-34 T 09-03-2017 TK78_RS32735 5d8f8c2739e55dd0527812800c0d4d65 182 Pfam PF11706 CGNR zinc finger 131 173 2.7E-17 T 09-03-2017 IPR021005 Zinc finger, CGNR TK78_RS33860 be810eddb7554c7934abf6a51d99ef65 488 SUPERFAMILY SSF103473 8 199 8.37E-64 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS33860 be810eddb7554c7934abf6a51d99ef65 488 SUPERFAMILY SSF103473 250 460 8.37E-64 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS33860 be810eddb7554c7934abf6a51d99ef65 488 Pfam PF07690 Major Facilitator Superfamily 23 411 1.6E-49 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS33860 be810eddb7554c7934abf6a51d99ef65 488 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 16 417 1.6E-85 T 09-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 TK78_RS33860 be810eddb7554c7934abf6a51d99ef65 488 Gene3D G3DSA:1.20.1250.20 15 195 2.2E-32 T 09-03-2017 TK78_RS33860 be810eddb7554c7934abf6a51d99ef65 488 Gene3D G3DSA:1.20.1250.20 266 468 7.0E-16 T 09-03-2017 TK78_RS20415 fa2e8817f75d17c69c196cae985988ca 174 Pfam PF13508 Acetyltransferase (GNAT) domain 77 163 1.8E-12 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS20415 fa2e8817f75d17c69c196cae985988ca 174 SUPERFAMILY SSF55729 13 171 1.22E-25 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS20415 fa2e8817f75d17c69c196cae985988ca 174 Gene3D G3DSA:3.40.630.30 15 169 1.7E-28 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS23665 0f322328eff088b1b9e05253174096b9 329 ProSitePatterns PS01053 Arginase family signature. 240 261 - T 09-03-2017 IPR020855 Ureohydrolase, manganese-binding site GO:0016813|GO:0046872 TK78_RS23665 0f322328eff088b1b9e05253174096b9 329 PRINTS PR00116 Arginase signature 124 139 7.9E-15 T 09-03-2017 IPR006035 Ureohydrolase GO:0046872 TK78_RS23665 0f322328eff088b1b9e05253174096b9 329 PRINTS PR00116 Arginase signature 237 266 7.9E-15 T 09-03-2017 IPR006035 Ureohydrolase GO:0046872 TK78_RS23665 0f322328eff088b1b9e05253174096b9 329 SUPERFAMILY SSF52768 17 312 5.58E-98 T 09-03-2017 TK78_RS23665 0f322328eff088b1b9e05253174096b9 329 PIRSF PIRSF036979 16 316 2.1E-108 T 09-03-2017 IPR006035 Ureohydrolase GO:0046872 TK78_RS23665 0f322328eff088b1b9e05253174096b9 329 Gene3D G3DSA:3.40.800.10 12 314 2.3E-116 T 09-03-2017 IPR023696 Ureohydrolase domain TK78_RS23665 0f322328eff088b1b9e05253174096b9 329 TIGRFAM TIGR01230 agmatinase: agmatinase 37 309 5.9E-69 T 09-03-2017 IPR005925 Agmatinase-related KEGG: 00330+3.5.3.11|MetaCyc: PWY-40|MetaCyc: PWY-6305|Reactome: R-HSA-351143 TK78_RS23665 0f322328eff088b1b9e05253174096b9 329 Pfam PF00491 Arginase family 38 308 5.5E-90 T 09-03-2017 IPR006035 Ureohydrolase GO:0046872 TK78_RS19485 4accdf66e33a334d5e167fe21cc5b311 286 Gene3D G3DSA:2.60.130.10 69 223 4.7E-44 T 09-03-2017 IPR015889 Intradiol ring-cleavage dioxygenase, core GO:0005506|GO:0016702|GO:0055114 TK78_RS19485 4accdf66e33a334d5e167fe21cc5b311 286 Pfam PF00775 Dioxygenase 77 221 1.1E-18 T 09-03-2017 IPR000627 Intradiol ring-cleavage dioxygenase, C-terminal GO:0003824|GO:0006725|GO:0008199|GO:0055114 TK78_RS19485 4accdf66e33a334d5e167fe21cc5b311 286 Pfam PF02839 Carbohydrate binding domain 243 283 1.4E-9 T 09-03-2017 IPR003610 Carbohydrate-binding module family 5/12 GO:0004553|GO:0005576|GO:0005975|GO:0030246 TK78_RS19485 4accdf66e33a334d5e167fe21cc5b311 286 Gene3D G3DSA:2.10.10.20 242 285 6.6E-23 T 09-03-2017 IPR003610 Carbohydrate-binding module family 5/12 GO:0004553|GO:0005576|GO:0005975|GO:0030246 TK78_RS19485 4accdf66e33a334d5e167fe21cc5b311 286 SUPERFAMILY SSF51055 243 284 8.63E-15 T 09-03-2017 IPR003610 Carbohydrate-binding module family 5/12 GO:0004553|GO:0005576|GO:0005975|GO:0030246 TK78_RS19485 4accdf66e33a334d5e167fe21cc5b311 286 SUPERFAMILY SSF49482 70 221 8.9E-45 T 09-03-2017 IPR015889 Intradiol ring-cleavage dioxygenase, core GO:0005506|GO:0016702|GO:0055114 TK78_RS19485 4accdf66e33a334d5e167fe21cc5b311 286 SMART SM00495 240 286 4.7E-11 T 09-03-2017 IPR003610 Carbohydrate-binding module family 5/12 GO:0004553|GO:0005576|GO:0005975|GO:0030246 TK78_RS13550 a0f2452642728ba028d1a6bf2684e3fc 336 ProSitePatterns PS00444 Polyprenyl synthases signature 2. 212 224 - T 09-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 TK78_RS13550 a0f2452642728ba028d1a6bf2684e3fc 336 Pfam PF00348 Polyprenyl synthetase 42 258 1.6E-57 T 09-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 TK78_RS13550 a0f2452642728ba028d1a6bf2684e3fc 336 Gene3D G3DSA:1.10.600.10 16 334 3.2E-90 T 09-03-2017 IPR008949 Isoprenoid synthase domain TK78_RS13550 a0f2452642728ba028d1a6bf2684e3fc 336 SUPERFAMILY SSF48576 19 334 2.49E-83 T 09-03-2017 IPR008949 Isoprenoid synthase domain TK78_RS13505 cef62eaced0d31010b20159e92a725b5 282 TIGRFAM TIGR01484 HAD-SF-IIB: HAD hydrolase, family IIB 9 236 9.0E-17 T 09-03-2017 IPR006379 HAD-superfamily hydrolase, subfamily IIB Reactome: R-HSA-446205 TK78_RS13505 cef62eaced0d31010b20159e92a725b5 282 SUPERFAMILY SSF56784 7 267 5.72E-56 T 09-03-2017 IPR023214 HAD-like domain TK78_RS13505 cef62eaced0d31010b20159e92a725b5 282 Gene3D G3DSA:3.40.50.1000 7 77 1.8E-44 T 09-03-2017 IPR023214 HAD-like domain TK78_RS13505 cef62eaced0d31010b20159e92a725b5 282 Gene3D G3DSA:3.40.50.1000 172 267 1.8E-44 T 09-03-2017 IPR023214 HAD-like domain TK78_RS13505 cef62eaced0d31010b20159e92a725b5 282 Pfam PF08282 haloacid dehalogenase-like hydrolase 10 263 1.0E-44 T 09-03-2017 IPR023214 HAD-like domain TK78_RS12210 2b8413db712875d12027cc4c82b09f41 414 SUPERFAMILY SSF56784 249 399 2.71E-33 T 09-03-2017 IPR023214 HAD-like domain TK78_RS12210 2b8413db712875d12027cc4c82b09f41 414 Gene3D G3DSA:3.90.550.10 8 237 6.1E-69 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS12210 2b8413db712875d12027cc4c82b09f41 414 Pfam PF08282 haloacid dehalogenase-like hydrolase 326 384 2.3E-9 T 09-03-2017 IPR023214 HAD-like domain TK78_RS12210 2b8413db712875d12027cc4c82b09f41 414 Pfam PF02348 Cytidylyltransferase 11 193 2.1E-19 T 09-03-2017 IPR003329 Acylneuraminate cytidylyltransferase KEGG: 00540+2.7.7.38|MetaCyc: PWY-1269|Reactome: R-HSA-4085001 TK78_RS12210 2b8413db712875d12027cc4c82b09f41 414 SUPERFAMILY SSF53448 8 237 6.37E-48 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS12210 2b8413db712875d12027cc4c82b09f41 414 Gene3D G3DSA:3.40.50.1000 244 398 3.2E-35 T 09-03-2017 IPR023214 HAD-like domain TK78_RS05700 c5bc13719aae60879e418bd04513e031 303 SUPERFAMILY SSF46785 5 81 3.01E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05700 c5bc13719aae60879e418bd04513e031 303 SUPERFAMILY SSF46689 80 141 4.24E-14 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS05700 c5bc13719aae60879e418bd04513e031 303 Pfam PF00440 Bacterial regulatory proteins, tetR family 90 133 4.7E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS05700 c5bc13719aae60879e418bd04513e031 303 Gene3D G3DSA:1.10.357.10 138 298 4.0E-31 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS05700 c5bc13719aae60879e418bd04513e031 303 Gene3D G3DSA:1.10.10.10 7 73 4.9E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05700 c5bc13719aae60879e418bd04513e031 303 SMART SM00345 10 69 2.5E-12 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS05700 c5bc13719aae60879e418bd04513e031 303 SUPERFAMILY SSF48498 151 299 3.11E-21 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS05700 c5bc13719aae60879e418bd04513e031 303 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 149 295 4.3E-20 T 09-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 TK78_RS05700 c5bc13719aae60879e418bd04513e031 303 Pfam PF00392 Bacterial regulatory proteins, gntR family 7 69 7.5E-14 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS05700 c5bc13719aae60879e418bd04513e031 303 Gene3D G3DSA:1.10.10.60 74 137 1.1E-23 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS10120 55681d83b3ce3d5131dd8a157c84ffbe 290 Pfam PF00561 alpha/beta hydrolase fold 24 129 7.0E-16 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS10120 55681d83b3ce3d5131dd8a157c84ffbe 290 SUPERFAMILY SSF53474 2 285 4.95E-49 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS10120 55681d83b3ce3d5131dd8a157c84ffbe 290 Gene3D G3DSA:3.40.50.1820 2 286 1.8E-57 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS19895 eb5195b2e80a11ea020f486668321789 731 Gene3D G3DSA:1.10.510.10 120 269 1.8E-43 T 09-03-2017 TK78_RS19895 eb5195b2e80a11ea020f486668321789 731 Pfam PF13360 PQQ-like domain 542 725 8.4E-8 T 09-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat TK78_RS19895 eb5195b2e80a11ea020f486668321789 731 Pfam PF13360 PQQ-like domain 382 514 7.6E-13 T 09-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat TK78_RS19895 eb5195b2e80a11ea020f486668321789 731 SUPERFAMILY SSF50998 382 558 7.46E-16 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS19895 eb5195b2e80a11ea020f486668321789 731 Gene3D G3DSA:3.30.200.20 11 119 6.6E-13 T 09-03-2017 TK78_RS19895 eb5195b2e80a11ea020f486668321789 731 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 140 152 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS19895 eb5195b2e80a11ea020f486668321789 731 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 28 50 - T 09-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 TK78_RS19895 eb5195b2e80a11ea020f486668321789 731 Gene3D G3DSA:2.140.10.10 380 724 3.2E-24 T 09-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain TK78_RS19895 eb5195b2e80a11ea020f486668321789 731 SMART SM00564 398 429 810.0 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS19895 eb5195b2e80a11ea020f486668321789 731 SMART SM00564 439 470 510.0 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS19895 eb5195b2e80a11ea020f486668321789 731 SMART SM00564 611 646 450.0 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS19895 eb5195b2e80a11ea020f486668321789 731 SMART SM00564 655 687 1.2 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS19895 eb5195b2e80a11ea020f486668321789 731 SMART SM00564 477 509 20.0 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS19895 eb5195b2e80a11ea020f486668321789 731 SMART SM00220 22 271 1.9E-47 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS19895 eb5195b2e80a11ea020f486668321789 731 SUPERFAMILY SSF50998 610 724 1.73E-10 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS19895 eb5195b2e80a11ea020f486668321789 731 SUPERFAMILY SSF56112 19 269 3.51E-64 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS19895 eb5195b2e80a11ea020f486668321789 731 Pfam PF00069 Protein kinase domain 23 269 1.6E-39 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS22145 da12cc1fede61e3abdd3149ad71a1bfa 209 TIGRFAM TIGR01382 PfpI: intracellular protease, PfpI family 4 181 4.2E-47 T 09-03-2017 IPR006286 Peptidase C56, PfpI TK78_RS22145 da12cc1fede61e3abdd3149ad71a1bfa 209 Gene3D G3DSA:3.40.50.880 1 182 3.5E-50 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS22145 da12cc1fede61e3abdd3149ad71a1bfa 209 Pfam PF01965 DJ-1/PfpI family 4 178 2.0E-45 T 09-03-2017 IPR002818 DJ-1/PfpI TK78_RS22145 da12cc1fede61e3abdd3149ad71a1bfa 209 SUPERFAMILY SSF52317 1 182 4.95E-48 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS25565 185fb4050e712f61e51baf5c16677167 458 Pfam PF07730 Histidine kinase 233 298 4.3E-19 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS25565 185fb4050e712f61e51baf5c16677167 458 SUPERFAMILY SSF55874 323 434 1.02E-10 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS25565 185fb4050e712f61e51baf5c16677167 458 Gene3D G3DSA:3.30.565.10 348 440 3.2E-4 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS08680 e660dca975efc845ba03ec276e30cf56 204 Pfam PF00440 Bacterial regulatory proteins, tetR family 19 63 3.1E-11 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS08680 e660dca975efc845ba03ec276e30cf56 204 Gene3D G3DSA:1.10.357.10 13 200 4.2E-35 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS08680 e660dca975efc845ba03ec276e30cf56 204 Pfam PF13977 Bacterial transcriptional repressor 86 199 1.9E-23 T 09-03-2017 TK78_RS08680 e660dca975efc845ba03ec276e30cf56 204 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 39 62 1.9E-5 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS08680 e660dca975efc845ba03ec276e30cf56 204 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 18 31 1.9E-5 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS08680 e660dca975efc845ba03ec276e30cf56 204 SUPERFAMILY SSF48498 84 196 1.39E-15 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS08680 e660dca975efc845ba03ec276e30cf56 204 SUPERFAMILY SSF46689 5 90 3.98E-15 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS08640 be76b85c2af17c8164b1bddf6d70c00f 328 Gene3D G3DSA:3.40.50.300 3 262 5.4E-68 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08640 be76b85c2af17c8164b1bddf6d70c00f 328 Pfam PF00005 ABC transporter 26 188 1.8E-27 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS08640 be76b85c2af17c8164b1bddf6d70c00f 328 SUPERFAMILY SSF52540 6 258 2.84E-63 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08640 be76b85c2af17c8164b1bddf6d70c00f 328 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 240 304 5.6E-17 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS08640 be76b85c2af17c8164b1bddf6d70c00f 328 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 238 326 2.7E-22 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS08640 be76b85c2af17c8164b1bddf6d70c00f 328 ProSitePatterns PS00211 ABC transporters family signature. 161 175 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS08640 be76b85c2af17c8164b1bddf6d70c00f 328 SMART SM00382 35 238 1.5E-17 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS31375 80b08f0af56e8b59180f52c2ff7a1772 223 Pfam PF00196 Bacterial regulatory proteins, luxR family 154 210 7.5E-20 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS31375 80b08f0af56e8b59180f52c2ff7a1772 223 SUPERFAMILY SSF46894 140 216 5.44E-22 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS31375 80b08f0af56e8b59180f52c2ff7a1772 223 SUPERFAMILY SSF52172 1 135 3.27E-35 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS31375 80b08f0af56e8b59180f52c2ff7a1772 223 Gene3D G3DSA:3.40.50.2300 1 125 6.6E-39 T 09-03-2017 TK78_RS31375 80b08f0af56e8b59180f52c2ff7a1772 223 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 170 186 2.9E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS31375 80b08f0af56e8b59180f52c2ff7a1772 223 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 186 198 2.9E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS31375 80b08f0af56e8b59180f52c2ff7a1772 223 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 156 170 2.9E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS31375 80b08f0af56e8b59180f52c2ff7a1772 223 SMART SM00421 153 210 1.9E-24 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS31375 80b08f0af56e8b59180f52c2ff7a1772 223 Gene3D G3DSA:1.10.10.10 126 217 8.6E-32 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS31375 80b08f0af56e8b59180f52c2ff7a1772 223 SMART SM00448 2 117 7.8E-32 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS31375 80b08f0af56e8b59180f52c2ff7a1772 223 Pfam PF00072 Response regulator receiver domain 4 117 8.4E-28 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS10845 7fc0e159010794d86fb6411d8bdce608 106 Pfam PF00037 4Fe-4S binding domain 34 55 1.2E-8 T 09-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TK78_RS10845 7fc0e159010794d86fb6411d8bdce608 106 SUPERFAMILY SSF54862 3 87 4.19E-22 T 09-03-2017 TK78_RS10845 7fc0e159010794d86fb6411d8bdce608 106 Gene3D G3DSA:3.30.70.20 3 74 1.0E-19 T 09-03-2017 TK78_RS10845 7fc0e159010794d86fb6411d8bdce608 106 PRINTS PR00354 7Fe ferredoxin signature 35 52 3.9E-18 T 09-03-2017 IPR000813 7Fe ferredoxin GO:0009055 TK78_RS10845 7fc0e159010794d86fb6411d8bdce608 106 PRINTS PR00354 7Fe ferredoxin signature 19 29 3.9E-18 T 09-03-2017 IPR000813 7Fe ferredoxin GO:0009055 TK78_RS10845 7fc0e159010794d86fb6411d8bdce608 106 PRINTS PR00354 7Fe ferredoxin signature 9 19 3.9E-18 T 09-03-2017 IPR000813 7Fe ferredoxin GO:0009055 TK78_RS10845 7fc0e159010794d86fb6411d8bdce608 106 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 40 51 - T 09-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TK78_RS02645 5c66368ad11a489c124d8ae50dcca2cb 337 Pfam PF02607 B12 binding domain 136 205 2.3E-9 T 09-03-2017 IPR003759 Cobalamin (vitamin B12)-binding module, cap domain Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TK78_RS02645 5c66368ad11a489c124d8ae50dcca2cb 337 SMART SM00422 17 86 1.5E-4 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS02645 5c66368ad11a489c124d8ae50dcca2cb 337 Pfam PF02310 B12 binding domain 220 312 1.5E-7 T 09-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 TK78_RS02645 5c66368ad11a489c124d8ae50dcca2cb 337 Gene3D G3DSA:1.10.1660.10 18 83 2.5E-11 T 09-03-2017 TK78_RS02645 5c66368ad11a489c124d8ae50dcca2cb 337 SUPERFAMILY SSF46955 17 83 1.83E-11 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS02645 5c66368ad11a489c124d8ae50dcca2cb 337 Pfam PF13411 MerR HTH family regulatory protein 18 81 5.8E-12 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS02645 5c66368ad11a489c124d8ae50dcca2cb 337 SUPERFAMILY SSF52242 218 274 3.34E-5 T 09-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 TK78_RS29925 8f0eca1372a318909cd6cc28607745e5 430 ProSitePatterns PS00840 Uroporphyrin-III C-methyltransferase signature 2. 260 293 - T 09-03-2017 IPR003043 Uroporphiryn-III C-methyltransferase, conserved site GO:0008168|GO:0055114 KEGG: 00270+2.1.1.10|KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5441|MetaCyc: PWY-702|MetaCyc: PWY-7377 TK78_RS29925 8f0eca1372a318909cd6cc28607745e5 430 SUPERFAMILY SSF51735 19 122 6.4E-15 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS29925 8f0eca1372a318909cd6cc28607745e5 430 Gene3D G3DSA:3.30.950.10 296 417 5.1E-41 T 09-03-2017 IPR014776 Tetrapyrrole methylase, subdomain 2 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS29925 8f0eca1372a318909cd6cc28607745e5 430 SUPERFAMILY SSF53790 179 415 1.44E-70 T 09-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS29925 8f0eca1372a318909cd6cc28607745e5 430 Pfam PF13241 Putative NAD(P)-binding 23 130 5.6E-17 T 09-03-2017 IPR006367 Sirohaem synthase, N-terminal GO:0006779|GO:0019354|GO:0043115|GO:0055114 KEGG: 00270+2.1.1.10|KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5441|MetaCyc: PWY-702|MetaCyc: PWY-7377 TK78_RS29925 8f0eca1372a318909cd6cc28607745e5 430 Gene3D G3DSA:3.40.1010.10 182 295 2.5E-40 T 09-03-2017 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS29925 8f0eca1372a318909cd6cc28607745e5 430 TIGRFAM TIGR01469 cobA_cysG_Cterm: uroporphyrinogen-III C-methyltransferase 182 416 1.7E-82 T 09-03-2017 IPR006366 Uroporphyrin-III C-methyltransferase GO:0006779|GO:0008168|GO:0055114 KEGG: 00270+2.1.1.10|KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5441|MetaCyc: PWY-702|MetaCyc: PWY-7377 TK78_RS29925 8f0eca1372a318909cd6cc28607745e5 430 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 182 393 3.0E-48 T 09-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS29925 8f0eca1372a318909cd6cc28607745e5 430 Gene3D G3DSA:3.40.50.720 19 124 2.3E-27 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS30485 c5c157f600a7afc4e78c19cf1075860c 282 SUPERFAMILY SSF54913 210 281 2.33E-20 T 09-03-2017 IPR011322 Nitrogen regulatory PII-like, alpha/beta TK78_RS30485 c5c157f600a7afc4e78c19cf1075860c 282 TIGRFAM TIGR03455 HisG_C-term: ATP phosphoribosyltransferase, C-terminal domain 191 281 2.9E-29 T 09-03-2017 IPR013115 Histidine biosynthesis HisG, C-terminal GO:0000105|GO:0000287|GO:0003879|GO:0005737 KEGG: 00340+2.4.2.17 TK78_RS30485 c5c157f600a7afc4e78c19cf1075860c 282 Gene3D G3DSA:3.30.70.120 210 281 2.3E-27 T 09-03-2017 IPR015867 Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal TK78_RS30485 c5c157f600a7afc4e78c19cf1075860c 282 Pfam PF08029 HisG, C-terminal domain 207 278 9.1E-25 T 09-03-2017 IPR013115 Histidine biosynthesis HisG, C-terminal GO:0000105|GO:0000287|GO:0003879|GO:0005737 KEGG: 00340+2.4.2.17 TK78_RS30485 c5c157f600a7afc4e78c19cf1075860c 282 Hamap MF_00079 ATP phosphoribosyltransferase [hisG]. 1 282 31.292 T 09-03-2017 IPR020621 ATP phosphoribosyltransferase HisG, long form GO:0000105|GO:0003879 KEGG: 00340+2.4.2.17 TK78_RS30485 c5c157f600a7afc4e78c19cf1075860c 282 Pfam PF01634 ATP phosphoribosyltransferase 49 203 1.5E-40 T 09-03-2017 IPR013820 ATP phosphoribosyltransferase, catalytic domain GO:0000105|GO:0003879|GO:0005737 KEGG: 00340+2.4.2.17 TK78_RS30485 c5c157f600a7afc4e78c19cf1075860c 282 SUPERFAMILY SSF53850 1 208 1.09E-58 T 09-03-2017 TK78_RS30485 c5c157f600a7afc4e78c19cf1075860c 282 Gene3D G3DSA:3.40.190.10 1 107 6.2E-32 T 09-03-2017 TK78_RS30485 c5c157f600a7afc4e78c19cf1075860c 282 TIGRFAM TIGR00070 hisG: ATP phosphoribosyltransferase 2 182 9.6E-50 T 09-03-2017 IPR013820 ATP phosphoribosyltransferase, catalytic domain GO:0000105|GO:0003879|GO:0005737 KEGG: 00340+2.4.2.17 TK78_RS30485 c5c157f600a7afc4e78c19cf1075860c 282 Gene3D G3DSA:3.40.190.10 108 174 1.7E-23 T 09-03-2017 TK78_RS05905 99ad8f4eac2e7b04ecdf0bc3b5ee9650 463 Gene3D G3DSA:3.50.50.60 2 120 7.6E-23 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS05905 99ad8f4eac2e7b04ecdf0bc3b5ee9650 463 Pfam PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 341 442 2.2E-20 T 09-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 TK78_RS05905 99ad8f4eac2e7b04ecdf0bc3b5ee9650 463 SUPERFAMILY SSF51905 3 205 5.38E-42 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS05905 99ad8f4eac2e7b04ecdf0bc3b5ee9650 463 SUPERFAMILY SSF55424 334 453 3.44E-32 T 09-03-2017 IPR016156 FAD/NAD-linked reductase, dimerisation domain GO:0016491|GO:0050660|GO:0055114 TK78_RS05905 99ad8f4eac2e7b04ecdf0bc3b5ee9650 463 SUPERFAMILY SSF51905 160 326 2.79E-25 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS05905 99ad8f4eac2e7b04ecdf0bc3b5ee9650 463 Gene3D G3DSA:3.30.390.30 346 454 2.5E-38 T 09-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 TK78_RS05905 99ad8f4eac2e7b04ecdf0bc3b5ee9650 463 Gene3D G3DSA:3.50.50.60 121 325 4.0E-44 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS05905 99ad8f4eac2e7b04ecdf0bc3b5ee9650 463 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 5 317 1.3E-54 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS05905 99ad8f4eac2e7b04ecdf0bc3b5ee9650 463 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 160 178 5.1E-18 T 09-03-2017 TK78_RS05905 99ad8f4eac2e7b04ecdf0bc3b5ee9650 463 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 109 127 5.1E-18 T 09-03-2017 TK78_RS05905 99ad8f4eac2e7b04ecdf0bc3b5ee9650 463 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 245 261 5.1E-18 T 09-03-2017 TK78_RS05905 99ad8f4eac2e7b04ecdf0bc3b5ee9650 463 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 6 25 5.1E-18 T 09-03-2017 TK78_RS05905 99ad8f4eac2e7b04ecdf0bc3b5ee9650 463 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 246 260 7.4E-18 T 09-03-2017 TK78_RS05905 99ad8f4eac2e7b04ecdf0bc3b5ee9650 463 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 160 185 7.4E-18 T 09-03-2017 TK78_RS05905 99ad8f4eac2e7b04ecdf0bc3b5ee9650 463 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 288 295 7.4E-18 T 09-03-2017 TK78_RS05905 99ad8f4eac2e7b04ecdf0bc3b5ee9650 463 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 5 27 7.4E-18 T 09-03-2017 TK78_RS05905 99ad8f4eac2e7b04ecdf0bc3b5ee9650 463 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 398 413 7.4E-18 T 09-03-2017 TK78_RS08510 8bebdf96bbdcd90d3e7aa4400f980125 283 SMART SM00382 44 241 3.6E-17 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS08510 8bebdf96bbdcd90d3e7aa4400f980125 283 ProSitePatterns PS00211 ABC transporters family signature. 156 170 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS08510 8bebdf96bbdcd90d3e7aa4400f980125 283 Gene3D G3DSA:3.40.50.300 16 253 2.0E-64 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08510 8bebdf96bbdcd90d3e7aa4400f980125 283 Pfam PF00005 ABC transporter 38 183 3.6E-31 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS08510 8bebdf96bbdcd90d3e7aa4400f980125 283 SUPERFAMILY SSF52540 15 245 4.49E-61 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15205 c648cb4db78f86b46337eb81552dafb4 144 Pfam PF13340 Putative transposase of IS4/5 family (DUF4096) 6 77 1.7E-24 T 09-03-2017 IPR025161 Putative transposase IS4/IS5 family TK78_RS14800 365cad59f35ab3a76a5eba23637154a0 219 Gene3D G3DSA:3.40.50.1000 88 200 9.5E-7 T 09-03-2017 IPR023214 HAD-like domain TK78_RS14800 365cad59f35ab3a76a5eba23637154a0 219 SUPERFAMILY SSF56784 80 202 6.48E-10 T 09-03-2017 IPR023214 HAD-like domain TK78_RS14800 365cad59f35ab3a76a5eba23637154a0 219 Pfam PF03767 HAD superfamily, subfamily IIIB (Acid phosphatase) 113 214 2.0E-17 T 09-03-2017 IPR005519 Acid phosphatase, class B-like TK78_RS08995 5ccf65d4ad54a8cd92decc1e0f2f395e 506 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 44 441 3.9E-104 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS08995 5ccf65d4ad54a8cd92decc1e0f2f395e 506 Gene3D G3DSA:3.30.300.30 411 503 1.7E-24 T 09-03-2017 TK78_RS08995 5ccf65d4ad54a8cd92decc1e0f2f395e 506 Gene3D G3DSA:3.40.50.980 171 322 8.3E-36 T 09-03-2017 TK78_RS08995 5ccf65d4ad54a8cd92decc1e0f2f395e 506 Pfam PF13193 AMP-binding enzyme C-terminal domain 425 492 2.9E-6 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS08995 5ccf65d4ad54a8cd92decc1e0f2f395e 506 Gene3D G3DSA:3.40.50.980 18 170 8.2E-34 T 09-03-2017 TK78_RS08995 5ccf65d4ad54a8cd92decc1e0f2f395e 506 Pfam PF00501 AMP-binding enzyme 27 417 3.2E-74 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS08995 5ccf65d4ad54a8cd92decc1e0f2f395e 506 Gene3D G3DSA:2.30.38.10 334 409 1.5E-16 T 09-03-2017 TK78_RS08995 5ccf65d4ad54a8cd92decc1e0f2f395e 506 SUPERFAMILY SSF56801 17 503 3.66E-121 T 09-03-2017 TK78_RS08995 5ccf65d4ad54a8cd92decc1e0f2f395e 506 ProSitePatterns PS00455 Putative AMP-binding domain signature. 163 174 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS22375 a75aab6a03ac1cd5e45510c1d1d29872 186 Hamap MF_00758 UPF0301 protein YqgE [yqgE]. 5 183 26.46 T 09-03-2017 IPR003774 Protein of unknown function UPF0301 TK78_RS22375 a75aab6a03ac1cd5e45510c1d1d29872 186 SUPERFAMILY SSF143456 4 180 2.49E-46 T 09-03-2017 TK78_RS22375 a75aab6a03ac1cd5e45510c1d1d29872 186 Gene3D G3DSA:3.40.1740.10 127 173 7.6E-29 T 09-03-2017 TK78_RS22375 a75aab6a03ac1cd5e45510c1d1d29872 186 Gene3D G3DSA:3.40.1740.10 2 44 7.6E-29 T 09-03-2017 TK78_RS22375 a75aab6a03ac1cd5e45510c1d1d29872 186 Pfam PF02622 Uncharacterized ACR, COG1678 16 169 1.3E-35 T 09-03-2017 IPR003774 Protein of unknown function UPF0301 TK78_RS05200 cc686482c34ea5f6beac193d88e19dfc 307 SUPERFAMILY SSF53474 6 277 4.57E-37 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS05200 cc686482c34ea5f6beac193d88e19dfc 307 PRINTS PR00412 Epoxide hydrolase signature 221 237 1.4E-6 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS05200 cc686482c34ea5f6beac193d88e19dfc 307 PRINTS PR00412 Epoxide hydrolase signature 117 130 1.4E-6 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS05200 cc686482c34ea5f6beac193d88e19dfc 307 PRINTS PR00412 Epoxide hydrolase signature 59 74 1.4E-6 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS05200 cc686482c34ea5f6beac193d88e19dfc 307 PRINTS PR00412 Epoxide hydrolase signature 254 276 1.4E-6 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS05200 cc686482c34ea5f6beac193d88e19dfc 307 Gene3D G3DSA:3.40.50.1820 8 278 1.7E-36 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS05200 cc686482c34ea5f6beac193d88e19dfc 307 PRINTS PR00111 Alpha/beta hydrolase fold signature 103 116 1.0E-7 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS05200 cc686482c34ea5f6beac193d88e19dfc 307 PRINTS PR00111 Alpha/beta hydrolase fold signature 59 74 1.0E-7 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS05200 cc686482c34ea5f6beac193d88e19dfc 307 PRINTS PR00111 Alpha/beta hydrolase fold signature 223 237 1.0E-7 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS05200 cc686482c34ea5f6beac193d88e19dfc 307 PRINTS PR00111 Alpha/beta hydrolase fold signature 117 130 1.0E-7 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS05200 cc686482c34ea5f6beac193d88e19dfc 307 Pfam PF00561 alpha/beta hydrolase fold 45 265 1.1E-17 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS19725 15928cfb49187a969a9b03ddd41cfbd5 224 ProSitePatterns PS00622 LuxR-type HTH domain signature. 171 198 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS19725 15928cfb49187a969a9b03ddd41cfbd5 224 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 171 187 1.3E-14 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS19725 15928cfb49187a969a9b03ddd41cfbd5 224 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 187 199 1.3E-14 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS19725 15928cfb49187a969a9b03ddd41cfbd5 224 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 157 171 1.3E-14 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS19725 15928cfb49187a969a9b03ddd41cfbd5 224 Gene3D G3DSA:3.40.50.2300 2 123 7.4E-39 T 09-03-2017 TK78_RS19725 15928cfb49187a969a9b03ddd41cfbd5 224 Pfam PF00072 Response regulator receiver domain 5 117 2.0E-27 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS19725 15928cfb49187a969a9b03ddd41cfbd5 224 Pfam PF00196 Bacterial regulatory proteins, luxR family 157 211 3.4E-20 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS19725 15928cfb49187a969a9b03ddd41cfbd5 224 SUPERFAMILY SSF46894 153 217 1.84E-22 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS19725 15928cfb49187a969a9b03ddd41cfbd5 224 SUPERFAMILY SSF52172 2 135 1.42E-34 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS19725 15928cfb49187a969a9b03ddd41cfbd5 224 SMART SM00421 154 211 2.0E-24 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS19725 15928cfb49187a969a9b03ddd41cfbd5 224 SMART SM00448 3 116 4.2E-32 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS19725 15928cfb49187a969a9b03ddd41cfbd5 224 Gene3D G3DSA:1.10.10.10 124 218 8.4E-34 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS14105 acd8bbb2e087a552582f2ced3bdc75d4 406 Pfam PF02687 FtsX-like permease family 287 399 6.1E-22 T 09-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 TK78_RS14105 acd8bbb2e087a552582f2ced3bdc75d4 406 Pfam PF12704 MacB-like periplasmic core domain 39 203 6.6E-15 T 09-03-2017 IPR025857 MacB-like periplasmic core domain TK78_RS32400 f24bee3043d0a7540a142d7a5db8ad77 454 SUPERFAMILY SSF47384 227 299 1.41E-9 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS32400 f24bee3043d0a7540a142d7a5db8ad77 454 SMART SM00388 237 300 2.0E-7 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS32400 f24bee3043d0a7540a142d7a5db8ad77 454 Gene3D G3DSA:1.10.287.130 233 287 2.5E-7 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS32400 f24bee3043d0a7540a142d7a5db8ad77 454 SUPERFAMILY SSF55874 290 445 3.93E-28 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS32400 f24bee3043d0a7540a142d7a5db8ad77 454 PRINTS PR00344 Bacterial sensor protein C-terminal signature 398 408 1.5E-9 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS32400 f24bee3043d0a7540a142d7a5db8ad77 454 PRINTS PR00344 Bacterial sensor protein C-terminal signature 380 394 1.5E-9 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS32400 f24bee3043d0a7540a142d7a5db8ad77 454 PRINTS PR00344 Bacterial sensor protein C-terminal signature 432 445 1.5E-9 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS32400 f24bee3043d0a7540a142d7a5db8ad77 454 PRINTS PR00344 Bacterial sensor protein C-terminal signature 408 426 1.5E-9 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS32400 f24bee3043d0a7540a142d7a5db8ad77 454 Gene3D G3DSA:3.30.565.10 288 446 4.1E-29 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS32400 f24bee3043d0a7540a142d7a5db8ad77 454 SMART SM00387 340 448 6.3E-27 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS32400 f24bee3043d0a7540a142d7a5db8ad77 454 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 341 446 7.6E-14 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09065 2082fd02baf466a55c131503e81e8b19 466 SUPERFAMILY SSF52777 213 445 1.19E-12 T 09-03-2017 TK78_RS09065 2082fd02baf466a55c131503e81e8b19 466 SUPERFAMILY SSF52777 39 183 7.89E-17 T 09-03-2017 TK78_RS09065 2082fd02baf466a55c131503e81e8b19 466 Pfam PF00668 Condensation domain 38 291 9.0E-9 T 09-03-2017 IPR001242 Condensation domain TK78_RS15705 79bae337db0bd4e39c1631c69621784b 199 SMART SM00493 79 164 2.5E-19 T 09-03-2017 IPR006171 Toprim domain TK78_RS15705 79bae337db0bd4e39c1631c69621784b 199 Pfam PF00633 Helix-hairpin-helix motif 2 27 3.5E-6 T 09-03-2017 IPR000445 Helix-hairpin-helix motif GO:0003677 Reactome: R-HSA-110357 TK78_RS15705 79bae337db0bd4e39c1631c69621784b 199 Pfam PF02132 RecR protein 38 77 4.4E-16 T 09-03-2017 IPR023628 Recombination protein RecR, C4-type zinc finger TK78_RS15705 79bae337db0bd4e39c1631c69621784b 199 Gene3D G3DSA:3.40.50.140 115 169 1.3E-5 T 09-03-2017 IPR006171 Toprim domain TK78_RS15705 79bae337db0bd4e39c1631c69621784b 199 Hamap MF_00017 Recombination protein RecR [recR]. 1 197 108.933 T 09-03-2017 IPR000093 DNA recombination protein RecR GO:0003677|GO:0006281|GO:0006310 TK78_RS15705 79bae337db0bd4e39c1631c69621784b 199 Pfam PF13662 Toprim domain 79 170 1.6E-26 T 09-03-2017 IPR006171 Toprim domain TK78_RS15705 79bae337db0bd4e39c1631c69621784b 199 SUPERFAMILY SSF111304 3 197 1.83E-75 T 09-03-2017 IPR023627 Recombination protein RecR TK78_RS15705 79bae337db0bd4e39c1631c69621784b 199 ProSitePatterns PS01300 RecR protein signature. 56 77 - T 09-03-2017 IPR015967 Recombination protein RecR, conserved site GO:0006281|GO:0006310 TK78_RS15705 79bae337db0bd4e39c1631c69621784b 199 TIGRFAM TIGR00615 recR: recombination protein RecR 2 195 1.7E-85 T 09-03-2017 IPR000093 DNA recombination protein RecR GO:0003677|GO:0006281|GO:0006310 TK78_RS34240 c9e542a287f263eb50eb8c2977dcd7da 171 Pfam PF03067 Lytic polysaccharide mono-oxygenase, cellulose-degrading 31 168 2.5E-16 T 09-03-2017 IPR004302 Chitin-binding protein, N-terminal TK78_RS34240 c9e542a287f263eb50eb8c2977dcd7da 171 Gene3D G3DSA:2.70.50.50 31 170 5.5E-32 T 09-03-2017 TK78_RS34240 c9e542a287f263eb50eb8c2977dcd7da 171 SUPERFAMILY SSF81296 31 170 8.82E-36 T 09-03-2017 IPR014756 Immunoglobulin E-set TK78_RS12895 7ec49850a16d44330849bb9b21b1c77a 455 SUPERFAMILY SSF53187 132 439 1.19E-82 T 09-03-2017 TK78_RS12895 7ec49850a16d44330849bb9b21b1c77a 455 Gene3D G3DSA:3.40.630.10 131 445 9.0E-97 T 09-03-2017 TK78_RS12895 7ec49850a16d44330849bb9b21b1c77a 455 PRINTS PR00765 Carboxypeptidase A metalloprotease (M14) family signature 162 174 2.7E-11 T 09-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 TK78_RS12895 7ec49850a16d44330849bb9b21b1c77a 455 PRINTS PR00765 Carboxypeptidase A metalloprotease (M14) family signature 269 277 2.7E-11 T 09-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 TK78_RS12895 7ec49850a16d44330849bb9b21b1c77a 455 PRINTS PR00765 Carboxypeptidase A metalloprotease (M14) family signature 187 201 2.7E-11 T 09-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 TK78_RS12895 7ec49850a16d44330849bb9b21b1c77a 455 PRINTS PR00765 Carboxypeptidase A metalloprotease (M14) family signature 328 341 2.7E-11 T 09-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 TK78_RS12895 7ec49850a16d44330849bb9b21b1c77a 455 ProSitePatterns PS00132 Zinc carboxypeptidases, zinc-binding region 1 signature. 187 209 - T 09-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 TK78_RS12895 7ec49850a16d44330849bb9b21b1c77a 455 Pfam PF00246 Zinc carboxypeptidase 143 430 9.8E-70 T 09-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 TK78_RS12895 7ec49850a16d44330849bb9b21b1c77a 455 ProSitePatterns PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. 331 341 - T 09-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 TK78_RS12895 7ec49850a16d44330849bb9b21b1c77a 455 SMART SM00631 136 427 1.2E-101 T 09-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 TK78_RS33265 f49f36dd8a307b959bf8fdc8264747ec 305 PIRSF PIRSF035875 16 304 1.2E-62 T 09-03-2017 IPR017039 Virulence factor BrkB TK78_RS33265 f49f36dd8a307b959bf8fdc8264747ec 305 TIGRFAM TIGR00765 yihY_not_rbn: YihY family inner membrane protein 39 290 5.1E-30 T 09-03-2017 IPR017039 Virulence factor BrkB TK78_RS33265 f49f36dd8a307b959bf8fdc8264747ec 305 Pfam PF03631 Virulence factor BrkB 38 292 1.5E-53 T 09-03-2017 IPR017039 Virulence factor BrkB TK78_RS02430 efc602efaac36cc2b5c10d1fe4509204 173 SUPERFAMILY SSF55811 12 113 7.58E-14 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS02430 efc602efaac36cc2b5c10d1fe4509204 173 Gene3D G3DSA:3.90.79.10 13 110 4.7E-15 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS02430 efc602efaac36cc2b5c10d1fe4509204 173 ProSitePatterns PS00893 Nudix box signature. 49 70 - T 09-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 TK78_RS02430 efc602efaac36cc2b5c10d1fe4509204 173 Pfam PF00293 NUDIX domain 16 109 1.2E-11 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS27570 a027a21432f7cfc27f7bb7a1852bef07 475 SUPERFAMILY SSF51905 9 279 3.02E-15 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS27570 a027a21432f7cfc27f7bb7a1852bef07 475 Gene3D G3DSA:3.50.50.60 299 345 7.9E-7 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS27570 a027a21432f7cfc27f7bb7a1852bef07 475 Gene3D G3DSA:3.50.50.60 195 254 7.9E-7 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS27570 a027a21432f7cfc27f7bb7a1852bef07 475 SUPERFAMILY SSF51905 157 226 7.35E-8 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS27570 a027a21432f7cfc27f7bb7a1852bef07 475 SUPERFAMILY SSF51905 297 408 7.35E-8 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS27570 a027a21432f7cfc27f7bb7a1852bef07 475 Pfam PF13434 L-lysine 6-monooxygenase (NADPH-requiring) 11 363 2.2E-115 T 09-03-2017 IPR025700 L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase TK78_RS27570 a027a21432f7cfc27f7bb7a1852bef07 475 Gene3D G3DSA:3.50.50.60 98 138 1.0E-5 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS27570 a027a21432f7cfc27f7bb7a1852bef07 475 Gene3D G3DSA:3.50.50.60 346 367 1.0E-5 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS27925 83f45aeb9834acb3db94212a720e25e5 346 Pfam PF10128 Glucose-6-phosphate dehydrogenase subunit 53 298 8.0E-85 T 09-03-2017 IPR004555 Glucose-6-phosphate dehydrogenase assembly protein OpcA TK78_RS27925 83f45aeb9834acb3db94212a720e25e5 346 TIGRFAM TIGR00534 OpcA: glucose-6-phosphate dehydrogenase assembly protein OpcA 1 299 6.1E-91 T 09-03-2017 IPR004555 Glucose-6-phosphate dehydrogenase assembly protein OpcA TK78_RS33550 540ff8d5c3e40bf88a3af1121675f78c 420 Pfam PF07690 Major Facilitator Superfamily 20 365 1.8E-30 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS33550 540ff8d5c3e40bf88a3af1121675f78c 420 Gene3D G3DSA:1.20.1250.20 15 191 2.5E-25 T 09-03-2017 TK78_RS33550 540ff8d5c3e40bf88a3af1121675f78c 420 Gene3D G3DSA:1.20.1250.20 215 402 2.5E-13 T 09-03-2017 TK78_RS33550 540ff8d5c3e40bf88a3af1121675f78c 420 SUPERFAMILY SSF103473 15 398 2.22E-43 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS05395 f661e2ea357c8b4772ac6afdd0b10f79 413 SUPERFAMILY SSF54373 173 269 1.88E-6 T 09-03-2017 TK78_RS05395 f661e2ea357c8b4772ac6afdd0b10f79 413 SUPERFAMILY SSF51905 7 167 2.24E-35 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS05395 f661e2ea357c8b4772ac6afdd0b10f79 413 SUPERFAMILY SSF51905 278 366 2.24E-35 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS05395 f661e2ea357c8b4772ac6afdd0b10f79 413 Gene3D G3DSA:3.50.50.60 7 172 1.0E-25 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS05395 f661e2ea357c8b4772ac6afdd0b10f79 413 Gene3D G3DSA:3.50.50.60 279 359 1.0E-25 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS05395 f661e2ea357c8b4772ac6afdd0b10f79 413 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 306 322 3.1E-8 T 09-03-2017 TK78_RS05395 f661e2ea357c8b4772ac6afdd0b10f79 413 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 7 29 3.1E-8 T 09-03-2017 TK78_RS05395 f661e2ea357c8b4772ac6afdd0b10f79 413 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 291 306 3.1E-8 T 09-03-2017 TK78_RS05395 f661e2ea357c8b4772ac6afdd0b10f79 413 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 146 161 3.1E-8 T 09-03-2017 TK78_RS05395 f661e2ea357c8b4772ac6afdd0b10f79 413 Pfam PF01494 FAD binding domain 111 352 1.0E-6 T 09-03-2017 IPR002938 FAD-binding domain GO:0071949 TK78_RS27375 d01fd3e7a43cb446811356d1d35dd55c 399 SUPERFAMILY SSF89796 7 398 4.71E-128 T 09-03-2017 IPR023606 CoA-transferase family III domain TK78_RS27375 d01fd3e7a43cb446811356d1d35dd55c 399 Gene3D G3DSA:3.40.50.10540 6 219 1.1E-108 T 09-03-2017 IPR023606 CoA-transferase family III domain TK78_RS27375 d01fd3e7a43cb446811356d1d35dd55c 399 Gene3D G3DSA:3.40.50.10540 309 398 1.1E-108 T 09-03-2017 IPR023606 CoA-transferase family III domain TK78_RS27375 d01fd3e7a43cb446811356d1d35dd55c 399 Pfam PF02515 CoA-transferase family III 9 376 4.6E-122 T 09-03-2017 IPR003673 CoA-transferase family III GO:0003824 TK78_RS27375 d01fd3e7a43cb446811356d1d35dd55c 399 Gene3D G3DSA:3.30.1540.10 226 308 5.2E-22 T 09-03-2017 TK78_RS21295 5209295c45a1943adbb7c113bc9f93e3 146 Gene3D G3DSA:3.40.630.30 46 146 5.9E-23 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS21295 5209295c45a1943adbb7c113bc9f93e3 146 Pfam PF00583 Acetyltransferase (GNAT) family 56 125 3.6E-8 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS21295 5209295c45a1943adbb7c113bc9f93e3 146 SUPERFAMILY SSF55729 42 146 1.08E-21 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS13835 2be68ded211ffdeafb4fd91b65b95751 401 Gene3D G3DSA:1.20.140.10 257 371 4.8E-28 T 09-03-2017 TK78_RS13835 2be68ded211ffdeafb4fd91b65b95751 401 SUPERFAMILY SSF56645 1 230 2.75E-30 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS13835 2be68ded211ffdeafb4fd91b65b95751 401 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 6 118 7.0E-20 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS13835 2be68ded211ffdeafb4fd91b65b95751 401 SUPERFAMILY SSF47203 254 381 9.18E-30 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS13835 2be68ded211ffdeafb4fd91b65b95751 401 Gene3D G3DSA:1.10.540.10 1 119 6.2E-21 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS13835 2be68ded211ffdeafb4fd91b65b95751 401 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 257 382 1.0E-21 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS26895 32ce8333170b29a13328cc476b9acfdd 259 Gene3D G3DSA:3.40.50.1820 12 245 2.1E-50 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS26895 32ce8333170b29a13328cc476b9acfdd 259 Pfam PF12146 Serine aminopeptidase, S33 19 229 5.2E-21 T 09-03-2017 IPR022742 Serine aminopeptidase, S33 TK78_RS26895 32ce8333170b29a13328cc476b9acfdd 259 SUPERFAMILY SSF53474 14 245 2.53E-37 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS26895 32ce8333170b29a13328cc476b9acfdd 259 PIRSF PIRSF017388 1 248 6.6E-78 T 09-03-2017 IPR012354 Esterase/lipase GO:0052689 TK78_RS13465 675a85f70ebfda501a1a369ac2c28bb4 589 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 9 31 3.0E-43 T 09-03-2017 TK78_RS13465 675a85f70ebfda501a1a369ac2c28bb4 589 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 159 174 3.0E-43 T 09-03-2017 TK78_RS13465 675a85f70ebfda501a1a369ac2c28bb4 589 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 303 319 3.0E-43 T 09-03-2017 TK78_RS13465 675a85f70ebfda501a1a369ac2c28bb4 589 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 321 339 3.0E-43 T 09-03-2017 TK78_RS13465 675a85f70ebfda501a1a369ac2c28bb4 589 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 339 355 3.0E-43 T 09-03-2017 TK78_RS13465 675a85f70ebfda501a1a369ac2c28bb4 589 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 288 303 3.0E-43 T 09-03-2017 TK78_RS13465 675a85f70ebfda501a1a369ac2c28bb4 589 SUPERFAMILY SSF52833 432 570 3.35E-8 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS13465 675a85f70ebfda501a1a369ac2c28bb4 589 Pfam PF01494 FAD binding domain 8 352 5.0E-80 T 09-03-2017 IPR002938 FAD-binding domain GO:0071949 TK78_RS13465 675a85f70ebfda501a1a369ac2c28bb4 589 Gene3D G3DSA:3.40.30.20 522 569 2.1E-6 T 09-03-2017 TK78_RS13465 675a85f70ebfda501a1a369ac2c28bb4 589 Gene3D G3DSA:3.50.50.60 276 355 2.6E-55 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS13465 675a85f70ebfda501a1a369ac2c28bb4 589 Gene3D G3DSA:3.50.50.60 9 185 2.6E-55 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS13465 675a85f70ebfda501a1a369ac2c28bb4 589 SUPERFAMILY SSF51905 275 359 1.45E-57 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS13465 675a85f70ebfda501a1a369ac2c28bb4 589 SUPERFAMILY SSF51905 9 180 1.45E-57 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS26180 b2d934576af6ee51cabb07de82366236 440 SUPERFAMILY SSF103473 37 428 9.94E-45 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS26180 b2d934576af6ee51cabb07de82366236 440 Gene3D G3DSA:1.20.1250.20 253 422 2.9E-16 T 09-03-2017 TK78_RS26180 b2d934576af6ee51cabb07de82366236 440 Gene3D G3DSA:1.20.1250.20 36 225 2.4E-20 T 09-03-2017 TK78_RS26180 b2d934576af6ee51cabb07de82366236 440 Pfam PF05977 Transmembrane secretion effector 30 424 1.1E-26 T 09-03-2017 IPR010290 Transmembrane secretion effector TK78_RS12435 8149603b04f89fb9448850b896e1ea93 402 Pfam PF00202 Aminotransferase class-III 16 399 1.0E-114 T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS12435 8149603b04f89fb9448850b896e1ea93 402 Gene3D G3DSA:3.40.640.10 60 290 5.1E-82 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS12435 8149603b04f89fb9448850b896e1ea93 402 SUPERFAMILY SSF53383 4 399 1.05E-115 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS12435 8149603b04f89fb9448850b896e1ea93 402 Gene3D G3DSA:3.90.1150.10 291 401 1.1E-35 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS12435 8149603b04f89fb9448850b896e1ea93 402 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 223 260 - T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS12435 8149603b04f89fb9448850b896e1ea93 402 TIGRFAM TIGR01885 Orn_aminotrans: ornithine--oxo-acid transaminase 5 399 5.3E-146 T 09-03-2017 IPR010164 Ornithine aminotransferase GO:0008483|GO:0030170 KEGG: 00330+2.6.1.13|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344|MetaCyc: PWY-6922|Reactome: R-HSA-70614 TK78_RS13220 de8f6bcfaf29b4b51077d2710d7da58d 1299 SMART SM00663 310 589 6.6E-174 T 09-03-2017 IPR006592 RNA polymerase, N-terminal GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13220 de8f6bcfaf29b4b51077d2710d7da58d 1299 Gene3D G3DSA:2.40.50.100 1041 1095 8.0E-7 T 09-03-2017 TK78_RS13220 de8f6bcfaf29b4b51077d2710d7da58d 1299 SUPERFAMILY SSF64484 5 1251 0.0 T 09-03-2017 TK78_RS13220 de8f6bcfaf29b4b51077d2710d7da58d 1299 Gene3D G3DSA:2.40.40.20 424 451 3.7E-38 T 09-03-2017 TK78_RS13220 de8f6bcfaf29b4b51077d2710d7da58d 1299 Gene3D G3DSA:2.40.40.20 492 564 3.7E-38 T 09-03-2017 TK78_RS13220 de8f6bcfaf29b4b51077d2710d7da58d 1299 Pfam PF00623 RNA polymerase Rpb1, domain 2 468 560 9.6E-28 T 09-03-2017 IPR000722 RNA polymerase, alpha subunit GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13220 de8f6bcfaf29b4b51077d2710d7da58d 1299 Pfam PF00623 RNA polymerase Rpb1, domain 2 419 480 1.3E-8 T 09-03-2017 IPR000722 RNA polymerase, alpha subunit GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13220 de8f6bcfaf29b4b51077d2710d7da58d 1299 Pfam PF04998 RNA polymerase Rpb1, domain 5 838 1199 9.5E-67 T 09-03-2017 IPR007081 RNA polymerase Rpb1, domain 5 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13220 de8f6bcfaf29b4b51077d2710d7da58d 1299 Hamap MF_01322 DNA-directed RNA polymerase subunit beta' [rpoC]. 5 1260 10.01 T 09-03-2017 IPR012754 DNA-directed RNA polymerase, subunit beta-prime GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13220 de8f6bcfaf29b4b51077d2710d7da58d 1299 Pfam PF04997 RNA polymerase Rpb1, domain 1 7 417 2.1E-82 T 09-03-2017 IPR007080 RNA polymerase Rpb1, domain 1 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13220 de8f6bcfaf29b4b51077d2710d7da58d 1299 Pfam PF05000 RNA polymerase Rpb1, domain 4 760 824 7.1E-14 T 09-03-2017 IPR007083 RNA polymerase Rpb1, domain 4 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13220 de8f6bcfaf29b4b51077d2710d7da58d 1299 TIGRFAM TIGR02386 rpoC_TIGR: DNA-directed RNA polymerase, beta' subunit 10 1251 0.0 T 09-03-2017 IPR012754 DNA-directed RNA polymerase, subunit beta-prime GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS13220 de8f6bcfaf29b4b51077d2710d7da58d 1299 Pfam PF04983 RNA polymerase Rpb1, domain 3 564 731 5.0E-22 T 09-03-2017 IPR007066 RNA polymerase Rpb1, domain 3 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TK78_RS09690 0211ae12cc75a4a32584a4c26b29a932 178 Gene3D G3DSA:1.20.5.620 76 135 4.5E-12 T 09-03-2017 IPR028987 F-type ATP synthase subunit B-like, membrane domain TK78_RS09690 0211ae12cc75a4a32584a4c26b29a932 178 SUPERFAMILY SSF81573 76 134 9.29E-11 T 09-03-2017 IPR028987 F-type ATP synthase subunit B-like, membrane domain TK78_RS09690 0211ae12cc75a4a32584a4c26b29a932 178 Pfam PF00430 ATP synthase B/B' CF(0) 20 149 1.9E-28 T 09-03-2017 IPR002146 ATPase, F0 complex, subunit B/B', bacterial/chloroplast GO:0015078|GO:0015986|GO:0045263 TK78_RS09690 0211ae12cc75a4a32584a4c26b29a932 178 Hamap MF_01398 ATP synthase subunit b [atpF]. 4 170 11.934 T 09-03-2017 IPR002146 ATPase, F0 complex, subunit B/B', bacterial/chloroplast GO:0015078|GO:0015986|GO:0045263 TK78_RS09690 0211ae12cc75a4a32584a4c26b29a932 178 TIGRFAM TIGR01144 ATP_synt_b: ATP synthase F0, B subunit 24 170 6.8E-26 T 09-03-2017 IPR005864 ATPase, F0 complex, subunit B, bacterial GO:0015078|GO:0015986|GO:0045263 TK78_RS32245 9a49766e13441005a27e2c208152f564 381 Pfam PF02625 XdhC and CoxI family 11 77 1.1E-20 T 09-03-2017 IPR003777 XdhC- CoxI TK78_RS32245 9a49766e13441005a27e2c208152f564 381 Pfam PF02625 XdhC and CoxI family 121 179 1.5E-8 T 09-03-2017 IPR003777 XdhC- CoxI TK78_RS32245 9a49766e13441005a27e2c208152f564 381 Pfam PF13478 XdhC Rossmann domain 206 348 5.4E-41 T 09-03-2017 IPR027051 XdhC Rossmann domain TK78_RS32230 3fd81b032f38f0ca3206469ab3456e52 201 Pfam PF01799 [2Fe-2S] binding domain 82 172 4.9E-29 T 09-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 TK78_RS32230 3fd81b032f38f0ca3206469ab3456e52 201 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 48 56 - T 09-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 TK78_RS32230 3fd81b032f38f0ca3206469ab3456e52 201 Gene3D G3DSA:3.10.20.30 10 83 2.6E-32 T 09-03-2017 IPR012675 Beta-grasp domain TK78_RS32230 3fd81b032f38f0ca3206469ab3456e52 201 SUPERFAMILY SSF54292 11 87 1.1E-25 T 09-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 TK78_RS32230 3fd81b032f38f0ca3206469ab3456e52 201 Gene3D G3DSA:1.10.150.120 84 185 3.6E-32 T 09-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 TK78_RS32230 3fd81b032f38f0ca3206469ab3456e52 201 SUPERFAMILY SSF47741 93 181 4.58E-28 T 09-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 TK78_RS32230 3fd81b032f38f0ca3206469ab3456e52 201 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 15 67 7.6E-9 T 09-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 TK78_RS30055 6f5531ba6c4312b419e0f4cf67cee8b8 225 Gene3D G3DSA:1.20.5.110 175 216 2.0E-15 T 09-03-2017 TK78_RS30055 6f5531ba6c4312b419e0f4cf67cee8b8 225 Pfam PF07885 Ion channel 132 210 2.7E-16 T 09-03-2017 IPR013099 Potassium channel domain TK78_RS30055 6f5531ba6c4312b419e0f4cf67cee8b8 225 SUPERFAMILY SSF81324 22 209 8.77E-30 T 09-03-2017 TK78_RS30055 6f5531ba6c4312b419e0f4cf67cee8b8 225 Gene3D G3DSA:1.10.287.70 123 173 5.9E-15 T 09-03-2017 TK78_RS02360 08d730bba1697417ee643945f705495a 543 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 407 517 1.4E-23 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS02360 08d730bba1697417ee643945f705495a 543 PRINTS PR00344 Bacterial sensor protein C-terminal signature 503 516 1.3E-11 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS02360 08d730bba1697417ee643945f705495a 543 PRINTS PR00344 Bacterial sensor protein C-terminal signature 479 497 1.3E-11 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS02360 08d730bba1697417ee643945f705495a 543 PRINTS PR00344 Bacterial sensor protein C-terminal signature 446 460 1.3E-11 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS02360 08d730bba1697417ee643945f705495a 543 Pfam PF00672 HAMP domain 204 271 1.2E-8 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS02360 08d730bba1697417ee643945f705495a 543 SUPERFAMILY SSF55874 354 519 2.1E-39 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS02360 08d730bba1697417ee643945f705495a 543 Pfam PF05227 CHASE3 domain 54 187 4.0E-26 T 09-03-2017 IPR007891 CHASE3 TK78_RS02360 08d730bba1697417ee643945f705495a 543 SUPERFAMILY SSF47384 284 363 1.92E-16 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS02360 08d730bba1697417ee643945f705495a 543 Gene3D G3DSA:1.10.287.130 289 361 2.0E-9 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS02360 08d730bba1697417ee643945f705495a 543 Gene3D G3DSA:3.30.565.10 370 522 1.8E-37 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS02360 08d730bba1697417ee643945f705495a 543 SMART SM00388 297 365 5.5E-10 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS02360 08d730bba1697417ee643945f705495a 543 Pfam PF00512 His Kinase A (phospho-acceptor) domain 298 362 2.7E-11 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS02360 08d730bba1697417ee643945f705495a 543 SMART SM00387 407 519 2.1E-32 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS02360 08d730bba1697417ee643945f705495a 543 SMART SM00304 223 275 1.5E-7 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS22500 c3bda0132221cd5d3e6a39dcbb47c6c4 205 Pfam PF12840 Helix-turn-helix domain 27 81 5.3E-11 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS22500 c3bda0132221cd5d3e6a39dcbb47c6c4 205 SUPERFAMILY SSF46785 25 102 5.75E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS22500 c3bda0132221cd5d3e6a39dcbb47c6c4 205 Gene3D G3DSA:1.10.10.10 26 98 3.7E-15 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS22500 c3bda0132221cd5d3e6a39dcbb47c6c4 205 SMART SM00418 26 106 8.2E-9 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS21790 427ff95753be571d6777b6ca1d08818c 225 SMART SM00862 146 222 1.3E-28 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS21790 427ff95753be571d6777b6ca1d08818c 225 SUPERFAMILY SSF52172 1 184 3.37E-41 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS21790 427ff95753be571d6777b6ca1d08818c 225 Pfam PF00072 Response regulator receiver domain 4 114 1.2E-26 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS21790 427ff95753be571d6777b6ca1d08818c 225 SMART SM00448 2 113 1.0E-40 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS21790 427ff95753be571d6777b6ca1d08818c 225 Gene3D G3DSA:1.10.10.10 131 224 5.9E-35 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS21790 427ff95753be571d6777b6ca1d08818c 225 Pfam PF00486 Transcriptional regulatory protein, C terminal 147 222 3.9E-28 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS21790 427ff95753be571d6777b6ca1d08818c 225 Gene3D G3DSA:3.40.50.2300 2 121 3.6E-39 T 09-03-2017 TK78_RS20355 a5c64b52c45e8f713a6afcf13224e5d7 428 Gene3D G3DSA:3.40.47.10 179 223 3.5E-43 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS20355 a5c64b52c45e8f713a6afcf13224e5d7 428 Gene3D G3DSA:3.40.47.10 305 427 3.5E-43 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS20355 a5c64b52c45e8f713a6afcf13224e5d7 428 Gene3D G3DSA:3.40.47.10 18 137 2.0E-48 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS20355 a5c64b52c45e8f713a6afcf13224e5d7 428 Gene3D G3DSA:3.40.47.10 224 299 2.0E-48 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS20355 a5c64b52c45e8f713a6afcf13224e5d7 428 SUPERFAMILY SSF53901 295 427 5.24E-30 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS20355 a5c64b52c45e8f713a6afcf13224e5d7 428 Pfam PF00108 Thiolase, N-terminal domain 18 287 2.0E-47 T 09-03-2017 IPR020616 Thiolase, N-terminal GO:0008152|GO:0016747 TK78_RS20355 a5c64b52c45e8f713a6afcf13224e5d7 428 PIRSF PIRSF000429 13 428 5.4E-103 T 09-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 TK78_RS20355 a5c64b52c45e8f713a6afcf13224e5d7 428 TIGRFAM TIGR01930 AcCoA-C-Actrans: acetyl-CoA C-acyltransferase 20 426 3.6E-116 T 09-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 TK78_RS20355 a5c64b52c45e8f713a6afcf13224e5d7 428 Pfam PF02803 Thiolase, C-terminal domain 295 427 3.4E-31 T 09-03-2017 IPR020617 Thiolase, C-terminal GO:0008152|GO:0016747 TK78_RS20355 a5c64b52c45e8f713a6afcf13224e5d7 428 SUPERFAMILY SSF53901 18 294 3.01E-58 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS09250 3d2220a674ac0b03e68d6b64e8f4ab48 415 Gene3D G3DSA:2.40.440.10 262 390 1.9E-17 T 09-03-2017 TK78_RS09250 3d2220a674ac0b03e68d6b64e8f4ab48 415 Pfam PF03734 L,D-transpeptidase catalytic domain 260 389 1.2E-11 T 09-03-2017 IPR005490 L,D-transpeptidase catalytic domain GO:0016740 TK78_RS09250 3d2220a674ac0b03e68d6b64e8f4ab48 415 SUPERFAMILY SSF141523 262 389 1.57E-21 T 09-03-2017 TK78_RS14990 b784f9e94413d50f4f422a8c9690503d 540 Gene3D G3DSA:3.50.7.10 195 368 6.0E-92 T 09-03-2017 IPR027409 GroEL-like apical domain TK78_RS14990 b784f9e94413d50f4f422a8c9690503d 540 SUPERFAMILY SSF48592 6 133 1.42E-75 T 09-03-2017 TK78_RS14990 b784f9e94413d50f4f422a8c9690503d 540 SUPERFAMILY SSF48592 404 518 1.42E-75 T 09-03-2017 TK78_RS14990 b784f9e94413d50f4f422a8c9690503d 540 Gene3D G3DSA:1.10.560.10 6 194 7.3E-48 T 09-03-2017 IPR027413 GroEL-like equatorial domain TK78_RS14990 b784f9e94413d50f4f422a8c9690503d 540 SUPERFAMILY SSF54849 137 202 2.29E-26 T 09-03-2017 TK78_RS14990 b784f9e94413d50f4f422a8c9690503d 540 SUPERFAMILY SSF52029 184 374 2.84E-82 T 09-03-2017 IPR027409 GroEL-like apical domain TK78_RS14990 b784f9e94413d50f4f422a8c9690503d 540 TIGRFAM TIGR02348 GroEL: chaperonin GroL 2 524 3.9E-247 T 09-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 TK78_RS14990 b784f9e94413d50f4f422a8c9690503d 540 Gene3D G3DSA:1.10.560.10 369 515 1.9E-39 T 09-03-2017 IPR027413 GroEL-like equatorial domain TK78_RS14990 b784f9e94413d50f4f422a8c9690503d 540 PRINTS PR00298 60kDa chaperonin signature 348 373 9.6E-70 T 09-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 TK78_RS14990 b784f9e94413d50f4f422a8c9690503d 540 PRINTS PR00298 60kDa chaperonin signature 26 52 9.6E-70 T 09-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 TK78_RS14990 b784f9e94413d50f4f422a8c9690503d 540 PRINTS PR00298 60kDa chaperonin signature 266 289 9.6E-70 T 09-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 TK78_RS14990 b784f9e94413d50f4f422a8c9690503d 540 PRINTS PR00298 60kDa chaperonin signature 396 417 9.6E-70 T 09-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 TK78_RS14990 b784f9e94413d50f4f422a8c9690503d 540 PRINTS PR00298 60kDa chaperonin signature 82 109 9.6E-70 T 09-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 TK78_RS14990 b784f9e94413d50f4f422a8c9690503d 540 Hamap MF_00600 60 kDa chaperonin [groL]. 1 538 41.357 T 09-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 TK78_RS14990 b784f9e94413d50f4f422a8c9690503d 540 ProSitePatterns PS00296 Chaperonins cpn60 signature. 403 414 - T 09-03-2017 IPR018370 Chaperonin Cpn60, conserved site GO:0005524|GO:0005737|GO:0006457 Reactome: R-HSA-1268020 TK78_RS14990 b784f9e94413d50f4f422a8c9690503d 540 Pfam PF00118 TCP-1/cpn60 chaperonin family 22 522 2.1E-94 T 09-03-2017 IPR002423 Chaperonin Cpn60/TCP-1 family GO:0005524 TK78_RS03800 f47ec723fd0dd5cab77d07177bd70ad1 403 Pfam PF03734 L,D-transpeptidase catalytic domain 249 371 1.5E-16 T 09-03-2017 IPR005490 L,D-transpeptidase catalytic domain GO:0016740 TK78_RS03800 f47ec723fd0dd5cab77d07177bd70ad1 403 Gene3D G3DSA:2.40.440.10 248 371 3.9E-18 T 09-03-2017 TK78_RS03800 f47ec723fd0dd5cab77d07177bd70ad1 403 SUPERFAMILY SSF141523 247 371 1.57E-24 T 09-03-2017 TK78_RS20890 b925778010fe7cc08dedb5a11f853f40 203 Gene3D G3DSA:3.40.50.10420 12 199 1.5E-48 T 09-03-2017 IPR024185 5-formyltetrahydrofolate cyclo-ligase-like domain TK78_RS20890 b925778010fe7cc08dedb5a11f853f40 203 Pfam PF01812 5-formyltetrahydrofolate cyclo-ligase family 12 193 1.2E-41 T 09-03-2017 IPR002698 5-formyltetrahydrofolate cyclo-ligase TK78_RS20890 b925778010fe7cc08dedb5a11f853f40 203 TIGRFAM TIGR02727 MTHFS_bact: 5-formyltetrahydrofolate cyclo-ligase 12 193 8.2E-38 T 09-03-2017 IPR002698 5-formyltetrahydrofolate cyclo-ligase TK78_RS20890 b925778010fe7cc08dedb5a11f853f40 203 PIRSF PIRSF006806 8 196 8.7E-32 T 09-03-2017 IPR002698 5-formyltetrahydrofolate cyclo-ligase TK78_RS20890 b925778010fe7cc08dedb5a11f853f40 203 SUPERFAMILY SSF100950 11 199 9.21E-43 T 09-03-2017 TK78_RS25760 2883a7858fb5822c7a031070b3e708e9 162 SUPERFAMILY SSF55729 10 152 3.77E-24 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS25760 2883a7858fb5822c7a031070b3e708e9 162 Gene3D G3DSA:3.40.630.30 8 162 1.4E-26 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS25760 2883a7858fb5822c7a031070b3e708e9 162 Pfam PF00583 Acetyltransferase (GNAT) family 66 142 1.8E-11 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS26555 7995d68e7a17275ddf71598df83e75b5 469 ProSitePatterns PS00181 Glutamine synthetase putative ATP-binding region signature. 256 271 - T 09-03-2017 IPR027303 Glutamine synthetase, glycine-rich site KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964|Reactome: R-HSA-210455|Reactome: R-HSA-70614 TK78_RS26555 7995d68e7a17275ddf71598df83e75b5 469 Pfam PF03951 Glutamine synthetase, beta-Grasp domain 16 94 1.4E-22 T 09-03-2017 IPR008147 Glutamine synthetase, beta-Grasp domain GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 TK78_RS26555 7995d68e7a17275ddf71598df83e75b5 469 ProSitePatterns PS00182 Glutamine synthetase class-I adenylation site. 385 397 - T 09-03-2017 IPR001637 Glutamine synthetase class-I, adenylation site KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 TK78_RS26555 7995d68e7a17275ddf71598df83e75b5 469 ProSitePatterns PS00180 Glutamine synthetase signature 1. 49 67 - T 09-03-2017 IPR027302 Glutamine synthetase, N-terminal conserved site KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964|Reactome: R-HSA-210455|Reactome: R-HSA-70614 TK78_RS26555 7995d68e7a17275ddf71598df83e75b5 469 TIGRFAM TIGR00653 GlnA: glutamine synthetase, type I 7 468 2.6E-200 T 09-03-2017 IPR004809 Glutamine synthetase type I GO:0004356|GO:0005737|GO:0009399 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 TK78_RS26555 7995d68e7a17275ddf71598df83e75b5 469 SUPERFAMILY SSF54368 5 99 1.24E-28 T 09-03-2017 IPR008147 Glutamine synthetase, beta-Grasp domain GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 TK78_RS26555 7995d68e7a17275ddf71598df83e75b5 469 Gene3D G3DSA:3.30.590.10 105 448 2.9E-137 T 09-03-2017 IPR014746 Glutamine synthetase/guanido kinase, catalytic domain GO:0003824 TK78_RS26555 7995d68e7a17275ddf71598df83e75b5 469 SMART SM01230 101 378 2.9E-152 T 09-03-2017 IPR008146 Glutamine synthetase, catalytic domain GO:0004356|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 TK78_RS26555 7995d68e7a17275ddf71598df83e75b5 469 SUPERFAMILY SSF55931 102 468 1.08E-137 T 09-03-2017 TK78_RS26555 7995d68e7a17275ddf71598df83e75b5 469 Pfam PF00120 Glutamine synthetase, catalytic domain 102 466 1.1E-138 T 09-03-2017 IPR008146 Glutamine synthetase, catalytic domain GO:0004356|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 TK78_RS26555 7995d68e7a17275ddf71598df83e75b5 469 Gene3D G3DSA:3.10.20.70 5 104 3.7E-33 T 09-03-2017 IPR008147 Glutamine synthetase, beta-Grasp domain GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 TK78_RS17895 a880fb4d9b2139782e4011d0e62f8a0d 395 Pfam PF13411 MerR HTH family regulatory protein 17 83 1.0E-11 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS17895 a880fb4d9b2139782e4011d0e62f8a0d 395 SUPERFAMILY SSF81606 150 390 7.59E-49 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS17895 a880fb4d9b2139782e4011d0e62f8a0d 395 Pfam PF13672 Protein phosphatase 2C 163 353 7.5E-9 T 09-03-2017 TK78_RS17895 a880fb4d9b2139782e4011d0e62f8a0d 395 SMART SM00331 156 391 1.8E-21 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS17895 a880fb4d9b2139782e4011d0e62f8a0d 395 SMART SM00332 141 389 3.1E-9 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS17895 a880fb4d9b2139782e4011d0e62f8a0d 395 Gene3D G3DSA:3.60.40.10 148 391 1.9E-57 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS17895 a880fb4d9b2139782e4011d0e62f8a0d 395 SUPERFAMILY SSF46955 16 110 1.83E-19 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS17895 a880fb4d9b2139782e4011d0e62f8a0d 395 Gene3D G3DSA:1.10.1660.10 14 83 3.7E-19 T 09-03-2017 TK78_RS17895 a880fb4d9b2139782e4011d0e62f8a0d 395 SMART SM00422 16 86 1.1E-9 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS17895 a880fb4d9b2139782e4011d0e62f8a0d 395 ProSitePatterns PS00552 MerR-type HTH domain signature. 19 41 - T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS26945 6b7e4195fa29b501c7f92f4a556b890a 288 SUPERFAMILY SSF51658 8 283 1.07E-72 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS26945 6b7e4195fa29b501c7f92f4a556b890a 288 ProSitePatterns PS00729 AP endonucleases family 2 signature 1. 71 79 - T 09-03-2017 IPR018246 AP endonuclease 2, zinc binding site GO:0008270 TK78_RS26945 6b7e4195fa29b501c7f92f4a556b890a 288 TIGRFAM TIGR00587 nfo: apurinic endonuclease (APN1) 8 282 1.8E-59 T 09-03-2017 IPR001719 AP endonuclease 2 GO:0003677|GO:0006281|GO:0008270 TK78_RS26945 6b7e4195fa29b501c7f92f4a556b890a 288 Hamap MF_00152 Probable endonuclease 4 [nfo]. 6 285 38.8 T 09-03-2017 IPR001719 AP endonuclease 2 GO:0003677|GO:0006281|GO:0008270 TK78_RS26945 6b7e4195fa29b501c7f92f4a556b890a 288 SMART SM00518 7 285 1.5E-112 T 09-03-2017 IPR001719 AP endonuclease 2 GO:0003677|GO:0006281|GO:0008270 TK78_RS26945 6b7e4195fa29b501c7f92f4a556b890a 288 ProSitePatterns PS00731 AP endonucleases family 2 signature 3. 220 236 - T 09-03-2017 IPR018246 AP endonuclease 2, zinc binding site GO:0008270 TK78_RS26945 6b7e4195fa29b501c7f92f4a556b890a 288 Pfam PF01261 Xylose isomerase-like TIM barrel 23 244 3.3E-30 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS26945 6b7e4195fa29b501c7f92f4a556b890a 288 Gene3D G3DSA:3.20.20.150 7 285 3.4E-83 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS26945 6b7e4195fa29b501c7f92f4a556b890a 288 ProSitePatterns PS00730 AP endonucleases family 2 signature 2. 180 187 - T 09-03-2017 IPR018246 AP endonuclease 2, zinc binding site GO:0008270 TK78_RS30580 baf1a83a0648d97171da520e9a52df2e 457 Pfam PF11700 Vacuole effluxer Atg22 like 24 449 2.1E-91 T 09-03-2017 IPR024671 Autophagy-related protein 22-like TK78_RS30580 baf1a83a0648d97171da520e9a52df2e 457 Gene3D G3DSA:1.20.1250.20 260 444 5.9E-20 T 09-03-2017 TK78_RS30580 baf1a83a0648d97171da520e9a52df2e 457 Gene3D G3DSA:1.20.1250.20 41 227 9.8E-12 T 09-03-2017 TK78_RS30580 baf1a83a0648d97171da520e9a52df2e 457 SUPERFAMILY SSF103473 31 444 9.29E-42 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS15010 8f639546e908d8cf844be8786bd290f9 316 Pfam PF00535 Glycosyl transferase family 2 38 160 1.7E-9 T 09-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 TK78_RS15010 8f639546e908d8cf844be8786bd290f9 316 SUPERFAMILY SSF53448 37 274 5.27E-57 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS15010 8f639546e908d8cf844be8786bd290f9 316 Gene3D G3DSA:3.90.550.10 37 213 1.4E-12 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS04695 50b96eb465ba073e8a6b18c59df55740 126 Gene3D G3DSA:2.30.110.10 6 100 6.5E-19 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS04695 50b96eb465ba073e8a6b18c59df55740 126 SUPERFAMILY SSF50475 6 117 6.71E-23 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS04695 50b96eb465ba073e8a6b18c59df55740 126 TIGRFAM TIGR03666 Rv2061_F420: PPOX class probable F420-dependent enzyme, Rv2061 family 2 124 1.7E-44 T 09-03-2017 IPR019965 PPOX class F420-dependent enzyme, family Rv2061, putative TK78_RS04695 50b96eb465ba073e8a6b18c59df55740 126 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 6 85 3.7E-12 T 09-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS08420 00455c6a3389adf50a381d2bd732eede 261 Pfam PF01557 Fumarylacetoacetate (FAA) hydrolase family 63 257 2.2E-68 T 09-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 TK78_RS08420 00455c6a3389adf50a381d2bd732eede 261 Gene3D G3DSA:3.90.850.10 54 259 6.3E-92 T 09-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 TK78_RS08420 00455c6a3389adf50a381d2bd732eede 261 Pfam PF10370 Domain of unknown function (DUF2437) 2 58 7.6E-10 T 09-03-2017 IPR018833 Domain of unknown function DUF2437 TK78_RS08420 00455c6a3389adf50a381d2bd732eede 261 SUPERFAMILY SSF56529 55 258 2.09E-79 T 09-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 TK78_RS32065 f30ce662c9d89e7b62948bd719219e0c 250 Pfam PF04476 Putative methanogenic enzyme for methanofuran 3 232 8.5E-82 T 09-03-2017 IPR007565 (5-formylfuran-3-yl)methyl phosphate synthase KEGG: 00680+4.2.3.153|KEGG: 00902+4.2.3.15|MetaCyc: PWY-3041|MetaCyc: PWY-5423|MetaCyc: PWY-7410 TK78_RS32065 f30ce662c9d89e7b62948bd719219e0c 250 SUPERFAMILY SSF51569 16 131 3.44E-6 T 09-03-2017 TK78_RS32065 f30ce662c9d89e7b62948bd719219e0c 250 PIRSF PIRSF015957 1 245 1.8E-117 T 09-03-2017 IPR007565 (5-formylfuran-3-yl)methyl phosphate synthase KEGG: 00680+4.2.3.153|KEGG: 00902+4.2.3.15|MetaCyc: PWY-3041|MetaCyc: PWY-5423|MetaCyc: PWY-7410 TK78_RS14250 47083152672f485339534dd6677c3dbe 308 Pfam PF03466 LysR substrate binding domain 112 288 1.5E-20 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS14250 47083152672f485339534dd6677c3dbe 308 Gene3D G3DSA:3.40.190.10 99 184 4.7E-12 T 09-03-2017 TK78_RS14250 47083152672f485339534dd6677c3dbe 308 SUPERFAMILY SSF46785 11 89 7.62E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS14250 47083152672f485339534dd6677c3dbe 308 SUPERFAMILY SSF53850 99 290 1.36E-22 T 09-03-2017 TK78_RS14250 47083152672f485339534dd6677c3dbe 308 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 13 71 2.2E-21 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS14250 47083152672f485339534dd6677c3dbe 308 Gene3D G3DSA:3.40.190.10 185 262 7.0E-10 T 09-03-2017 TK78_RS14250 47083152672f485339534dd6677c3dbe 308 Gene3D G3DSA:1.10.10.10 11 89 4.3E-25 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS14250 47083152672f485339534dd6677c3dbe 308 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 49 60 1.9E-8 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS14250 47083152672f485339534dd6677c3dbe 308 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 49 1.9E-8 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS14250 47083152672f485339534dd6677c3dbe 308 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 28 39 1.9E-8 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS23505 2cf9ea6db8a73058a9d21b376eb050a3 144 Pfam PF13376 Bacteriocin-protection, YdeI or OmpD-Associated 87 142 1.4E-19 T 09-03-2017 TK78_RS23505 2cf9ea6db8a73058a9d21b376eb050a3 144 Gene3D G3DSA:2.40.30.100 10 79 8.2E-13 T 09-03-2017 TK78_RS23505 2cf9ea6db8a73058a9d21b376eb050a3 144 Pfam PF08922 Domain of unknown function (DUF1905) 3 78 2.8E-17 T 09-03-2017 IPR015018 Protein of unknown function DUF1905 TK78_RS23505 2cf9ea6db8a73058a9d21b376eb050a3 144 SUPERFAMILY SSF141694 1 80 2.59E-17 T 09-03-2017 TK78_RS17380 ab4104a742f53a5f4b80c2d611dd328c 294 SMART SM01350 160 294 1.6E-6 T 09-03-2017 IPR006114 6-phosphogluconate dehydrogenase, C-terminal GO:0004616|GO:0006098|GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 TK78_RS17380 ab4104a742f53a5f4b80c2d611dd328c 294 PIRSF PIRSF000103 1 288 1.3E-25 T 09-03-2017 IPR015815 3-hydroxyisobutyrate dehydrogenase-related GO:0016491|GO:0055114 Reactome: R-HSA-70895 TK78_RS17380 ab4104a742f53a5f4b80c2d611dd328c 294 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 50 79 1.4E-37 T 09-03-2017 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 TK78_RS17380 ab4104a742f53a5f4b80c2d611dd328c 294 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 224 251 1.4E-37 T 09-03-2017 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 TK78_RS17380 ab4104a742f53a5f4b80c2d611dd328c 294 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 1 15 1.4E-37 T 09-03-2017 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 TK78_RS17380 ab4104a742f53a5f4b80c2d611dd328c 294 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 103 128 1.4E-37 T 09-03-2017 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 TK78_RS17380 ab4104a742f53a5f4b80c2d611dd328c 294 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 149 177 1.4E-37 T 09-03-2017 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 TK78_RS17380 ab4104a742f53a5f4b80c2d611dd328c 294 Gene3D G3DSA:3.40.50.720 1 161 3.7E-45 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS17380 ab4104a742f53a5f4b80c2d611dd328c 294 SUPERFAMILY SSF51735 1 143 2.82E-43 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS17380 ab4104a742f53a5f4b80c2d611dd328c 294 Pfam PF00393 6-phosphogluconate dehydrogenase, C-terminal domain 160 270 9.1E-27 T 09-03-2017 IPR006114 6-phosphogluconate dehydrogenase, C-terminal GO:0004616|GO:0006098|GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 TK78_RS17380 ab4104a742f53a5f4b80c2d611dd328c 294 SUPERFAMILY SSF48179 158 290 4.15E-42 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS17380 ab4104a742f53a5f4b80c2d611dd328c 294 Gene3D G3DSA:1.10.1040.10 162 270 2.5E-36 T 09-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 TK78_RS17380 ab4104a742f53a5f4b80c2d611dd328c 294 ProSitePatterns PS00461 6-phosphogluconate dehydrogenase signature. 228 240 - T 09-03-2017 IPR006184 6-phosphogluconate-binding site GO:0004616|GO:0006098|GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 TK78_RS17380 ab4104a742f53a5f4b80c2d611dd328c 294 TIGRFAM TIGR00872 gnd_rel: 6-phosphogluconate dehydrogenase (decarboxylating) 1 291 2.4E-102 T 09-03-2017 IPR004849 6-phosphogluconate dehydrogenase, YqeC-type GO:0055114 TK78_RS17380 ab4104a742f53a5f4b80c2d611dd328c 294 Pfam PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase 3 143 1.2E-35 T 09-03-2017 IPR006115 6-phosphogluconate dehydrogenase, NADP-binding GO:0004616|GO:0055114 TK78_RS14435 26e04c5df4ff85c184294b9050b946d9 263 Gene3D G3DSA:1.10.260.40 2 54 2.6E-10 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS14435 26e04c5df4ff85c184294b9050b946d9 263 Pfam PF13560 Helix-turn-helix domain 2 60 3.5E-12 T 09-03-2017 TK78_RS14435 26e04c5df4ff85c184294b9050b946d9 263 SMART SM00530 5 60 4.7E-9 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS14435 26e04c5df4ff85c184294b9050b946d9 263 SUPERFAMILY SSF47413 2 53 5.91E-9 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS27880 5049d950dc2507fe0132efbbf9963dc9 258 Gene3D G3DSA:3.20.20.70 4 255 3.7E-106 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS27880 5049d950dc2507fe0132efbbf9963dc9 258 Hamap MF_00147_B Triosephosphate isomerase [tpiA]. 4 256 39.78 T 09-03-2017 IPR022896 Triosephosphate isomerase, bacterial/eukaryotic GO:0004807|GO:0006096 KEGG: 00010+5.3.1.1|KEGG: 00051+5.3.1.1|KEGG: 00562+5.3.1.1|KEGG: 00710+5.3.1.1|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27880 5049d950dc2507fe0132efbbf9963dc9 258 SUPERFAMILY SSF51351 3 255 5.89E-92 T 09-03-2017 IPR000652 Triosephosphate isomerase GO:0004807|GO:0008152 KEGG: 00010+5.3.1.1|KEGG: 00051+5.3.1.1|KEGG: 00562+5.3.1.1|KEGG: 00710+5.3.1.1|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27880 5049d950dc2507fe0132efbbf9963dc9 258 TIGRFAM TIGR00419 tim: triose-phosphate isomerase 8 247 8.9E-55 T 09-03-2017 IPR000652 Triosephosphate isomerase GO:0004807|GO:0008152 KEGG: 00010+5.3.1.1|KEGG: 00051+5.3.1.1|KEGG: 00562+5.3.1.1|KEGG: 00710+5.3.1.1|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27880 5049d950dc2507fe0132efbbf9963dc9 258 Pfam PF00121 Triosephosphate isomerase 7 253 1.5E-88 T 09-03-2017 IPR000652 Triosephosphate isomerase GO:0004807|GO:0008152 KEGG: 00010+5.3.1.1|KEGG: 00051+5.3.1.1|KEGG: 00562+5.3.1.1|KEGG: 00710+5.3.1.1|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS27880 5049d950dc2507fe0132efbbf9963dc9 258 ProSitePatterns PS00171 Triosephosphate isomerase active site. 171 181 - T 09-03-2017 IPR020861 Triosephosphate isomerase, active site GO:0004807 KEGG: 00010+5.3.1.1|KEGG: 00051+5.3.1.1|KEGG: 00562+5.3.1.1|KEGG: 00710+5.3.1.1|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TK78_RS20810 433bf9c15d5ef865813dd8c769f48987 495 SUPERFAMILY SSF103473 6 201 2.49E-66 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS20810 433bf9c15d5ef865813dd8c769f48987 495 SUPERFAMILY SSF103473 255 477 2.49E-66 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS20810 433bf9c15d5ef865813dd8c769f48987 495 Pfam PF07690 Major Facilitator Superfamily 19 420 5.5E-54 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS20810 433bf9c15d5ef865813dd8c769f48987 495 Gene3D G3DSA:1.20.1250.20 266 474 1.3E-12 T 09-03-2017 TK78_RS20810 433bf9c15d5ef865813dd8c769f48987 495 PRINTS PR01036 Tetracycline resistance protein TetB signature 108 128 6.5E-8 T 09-03-2017 TK78_RS20810 433bf9c15d5ef865813dd8c769f48987 495 PRINTS PR01036 Tetracycline resistance protein TetB signature 138 162 6.5E-8 T 09-03-2017 TK78_RS20810 433bf9c15d5ef865813dd8c769f48987 495 PRINTS PR01036 Tetracycline resistance protein TetB signature 17 41 6.5E-8 T 09-03-2017 TK78_RS20810 433bf9c15d5ef865813dd8c769f48987 495 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 16 428 3.7E-72 T 09-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 TK78_RS20810 433bf9c15d5ef865813dd8c769f48987 495 Gene3D G3DSA:1.20.1250.20 8 198 8.1E-32 T 09-03-2017 TK78_RS24025 640a473b0054c3e4b1377010cc8b09fa 302 Gene3D G3DSA:3.40.50.300 1 226 8.0E-56 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24025 640a473b0054c3e4b1377010cc8b09fa 302 Pfam PF00005 ABC transporter 18 157 1.5E-22 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS24025 640a473b0054c3e4b1377010cc8b09fa 302 SUPERFAMILY SSF52540 2 224 1.75E-53 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24025 640a473b0054c3e4b1377010cc8b09fa 302 SMART SM00382 26 205 3.5E-10 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS07685 ab32ef8827d48d732be678fe5192d756 500 PIRSF PIRSF017804 18 500 4.9E-138 T 09-03-2017 IPR006707 Type VII secretion system membrane protein EccD TK78_RS07685 ab32ef8827d48d732be678fe5192d756 500 TIGRFAM TIGR03920 T7SS_EccD: type VII secretion integral membrane protein EccD 28 496 9.5E-53 T 09-03-2017 IPR006707 Type VII secretion system membrane protein EccD TK78_RS07685 ab32ef8827d48d732be678fe5192d756 500 Pfam PF08817 WXG100 protein secretion system (Wss), protein YukD 25 97 8.0E-19 T 09-03-2017 IPR024962 YukD-like TK78_RS34490 082c5e12d4b617f5b85c0f4beb584cff 502 Pfam PF07690 Major Facilitator Superfamily 17 406 1.2E-48 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS34490 082c5e12d4b617f5b85c0f4beb584cff 502 Gene3D G3DSA:1.20.1250.20 5 189 6.5E-30 T 09-03-2017 TK78_RS34490 082c5e12d4b617f5b85c0f4beb584cff 502 SUPERFAMILY SSF103473 462 489 5.23E-62 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS34490 082c5e12d4b617f5b85c0f4beb584cff 502 SUPERFAMILY SSF103473 4 190 5.23E-62 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS34490 082c5e12d4b617f5b85c0f4beb584cff 502 SUPERFAMILY SSF103473 246 416 5.23E-62 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS34490 082c5e12d4b617f5b85c0f4beb584cff 502 Gene3D G3DSA:1.20.1250.20 464 489 9.1E-14 T 09-03-2017 TK78_RS34490 082c5e12d4b617f5b85c0f4beb584cff 502 Gene3D G3DSA:1.20.1250.20 261 417 9.1E-14 T 09-03-2017 TK78_RS00360 0d09f29c59249a052f1d1c5fae4d9321 214 Gene3D G3DSA:3.40.50.970 1 163 1.7E-46 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS00360 0d09f29c59249a052f1d1c5fae4d9321 214 SUPERFAMILY SSF52518 2 160 3.88E-39 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS00360 0d09f29c59249a052f1d1c5fae4d9321 214 Gene3D G3DSA:3.40.50.1220 179 214 6.4E-4 T 09-03-2017 IPR029035 DHS-like NAD/FAD-binding domain TK78_RS00360 0d09f29c59249a052f1d1c5fae4d9321 214 SUPERFAMILY SSF52467 148 214 9.09E-6 T 09-03-2017 IPR029035 DHS-like NAD/FAD-binding domain TK78_RS00360 0d09f29c59249a052f1d1c5fae4d9321 214 Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain 1 162 4.5E-40 T 09-03-2017 IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain GO:0030976 TK78_RS29030 95aecdf40e32fd067abb08cea88749fa 232 SUPERFAMILY SSF48498 80 209 3.56E-28 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS29030 95aecdf40e32fd067abb08cea88749fa 232 PRINTS PR00400 Tetracycline repressor protein signature 190 204 3.8E-12 T 09-03-2017 IPR003012 Tetracycline transcriptional regulator, TetR GO:0045892|GO:0046677 TK78_RS29030 95aecdf40e32fd067abb08cea88749fa 232 PRINTS PR00400 Tetracycline repressor protein signature 26 49 3.8E-12 T 09-03-2017 IPR003012 Tetracycline transcriptional regulator, TetR GO:0045892|GO:0046677 TK78_RS29030 95aecdf40e32fd067abb08cea88749fa 232 PRINTS PR00400 Tetracycline repressor protein signature 81 100 3.8E-12 T 09-03-2017 IPR003012 Tetracycline transcriptional regulator, TetR GO:0045892|GO:0046677 TK78_RS29030 95aecdf40e32fd067abb08cea88749fa 232 SUPERFAMILY SSF46689 2 65 3.49E-15 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS29030 95aecdf40e32fd067abb08cea88749fa 232 ProSitePatterns PS01081 TetR-type HTH domain signature. 26 57 - T 09-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site TK78_RS29030 95aecdf40e32fd067abb08cea88749fa 232 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 14 27 3.0E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS29030 95aecdf40e32fd067abb08cea88749fa 232 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 35 58 3.0E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS29030 95aecdf40e32fd067abb08cea88749fa 232 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 77 206 8.7E-14 T 09-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 TK78_RS29030 95aecdf40e32fd067abb08cea88749fa 232 Gene3D G3DSA:1.10.357.10 2 210 1.4E-60 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS29030 95aecdf40e32fd067abb08cea88749fa 232 Pfam PF00440 Bacterial regulatory proteins, tetR family 14 60 2.1E-12 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS09235 744f44133fcd85aaf4ae18be70a2320a 171 Pfam PF13581 Histidine kinase-like ATPase domain 51 161 6.7E-11 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09235 744f44133fcd85aaf4ae18be70a2320a 171 Gene3D G3DSA:3.30.565.10 84 162 3.1E-4 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09235 744f44133fcd85aaf4ae18be70a2320a 171 SUPERFAMILY SSF55874 74 162 2.01E-9 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS15545 68f615ffe07e3725e834811fe42ecf8c 288 Gene3D G3DSA:1.10.10.10 9 83 3.2E-24 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS15545 68f615ffe07e3725e834811fe42ecf8c 288 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 53 69 1.4E-8 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS15545 68f615ffe07e3725e834811fe42ecf8c 288 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 39 53 1.4E-8 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS15545 68f615ffe07e3725e834811fe42ecf8c 288 Pfam PF00392 Bacterial regulatory proteins, gntR family 16 79 7.8E-18 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS15545 68f615ffe07e3725e834811fe42ecf8c 288 SMART SM00345 20 79 1.2E-16 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS15545 68f615ffe07e3725e834811fe42ecf8c 288 SUPERFAMILY SSF46785 9 83 1.93E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS21960 590d5729b449622a67b024655157bfb5 318 Gene3D G3DSA:3.40.50.10680 87 316 2.0E-82 T 09-03-2017 TK78_RS21960 590d5729b449622a67b024655157bfb5 318 Hamap MF_01257 2-phospho-L-lactate transferase [cofD]. 1 318 138.58 T 09-03-2017 IPR010115 2-phospho-L-lactate transferase GO:0000287|GO:0016780|GO:0051188 KEGG: 00680+2.7.8.28|MetaCyc: PWY-5198 TK78_RS21960 590d5729b449622a67b024655157bfb5 318 SUPERFAMILY SSF142338 3 315 5.23E-87 T 09-03-2017 TK78_RS21960 590d5729b449622a67b024655157bfb5 318 TIGRFAM TIGR01819 F420_cofD: 2-phospho-L-lactate transferase 3 309 6.9E-134 T 09-03-2017 IPR010115 2-phospho-L-lactate transferase GO:0000287|GO:0016780|GO:0051188 KEGG: 00680+2.7.8.28|MetaCyc: PWY-5198 TK78_RS21960 590d5729b449622a67b024655157bfb5 318 Pfam PF01933 Uncharacterised protein family UPF0052 3 275 2.3E-62 T 09-03-2017 IPR002882 LPPG:FO 2-phospho-L-lactate transferase CofD/UPF0052 TK78_RS05650 a46a6105298cc1fd026da3411c0082de 257 Pfam PF08044 Domain of unknown function (DUF1707) 13 63 4.2E-14 T 09-03-2017 IPR012551 Protein of unknown function DUF1707 TK78_RS05650 a46a6105298cc1fd026da3411c0082de 257 Pfam PF00498 FHA domain 110 173 2.0E-18 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS05650 a46a6105298cc1fd026da3411c0082de 257 SUPERFAMILY SSF49879 101 193 4.21E-26 T 09-03-2017 IPR008984 SMAD/FHA domain GO:0005515 TK78_RS05650 a46a6105298cc1fd026da3411c0082de 257 SMART SM00240 108 158 6.9E-14 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS05650 a46a6105298cc1fd026da3411c0082de 257 Gene3D G3DSA:2.60.200.20 105 180 7.8E-26 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS31630 556ae635c9e6ba9c984b4da0332be727 225 PIRSF PIRSF005624 11 225 6.5E-47 T 09-03-2017 TK78_RS31630 556ae635c9e6ba9c984b4da0332be727 225 Hamap MF_01389 Urease accessory protein UreG [ureG]. 25 223 44.07 T 09-03-2017 IPR004400 Urease accessory protein UreG GO:0003924|GO:0006807|GO:0016151 TK78_RS31630 556ae635c9e6ba9c984b4da0332be727 225 SUPERFAMILY SSF52540 22 222 3.85E-37 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31630 556ae635c9e6ba9c984b4da0332be727 225 TIGRFAM TIGR00101 ureG: urease accessory protein UreG 27 219 4.8E-84 T 09-03-2017 IPR004400 Urease accessory protein UreG GO:0003924|GO:0006807|GO:0016151 TK78_RS31630 556ae635c9e6ba9c984b4da0332be727 225 Gene3D G3DSA:3.40.50.300 25 217 3.8E-21 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31630 556ae635c9e6ba9c984b4da0332be727 225 Pfam PF02492 CobW/HypB/UreG, nucleotide-binding domain 29 198 2.1E-34 T 09-03-2017 IPR003495 CobW/HypB/UreG, nucleotide-binding domain TK78_RS07010 3b24de84ac20fbb9e2f429956d736da0 330 Gene3D G3DSA:3.40.50.2000 1 113 3.9E-16 T 09-03-2017 TK78_RS07010 3b24de84ac20fbb9e2f429956d736da0 330 Gene3D G3DSA:3.40.50.2000 168 296 3.6E-11 T 09-03-2017 TK78_RS07010 3b24de84ac20fbb9e2f429956d736da0 330 Pfam PF06722 Protein of unknown function (DUF1205) 131 219 4.3E-12 T 09-03-2017 IPR010610 Domain of unknown function DUF1205 TK78_RS07010 3b24de84ac20fbb9e2f429956d736da0 330 SUPERFAMILY SSF53756 1 328 1.3E-47 T 09-03-2017 TK78_RS08545 c2a9f6f36caa0555929d5a00f2d3c650 140 ProSitePatterns PS00893 Nudix box signature. 20 41 - T 09-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 TK78_RS08545 c2a9f6f36caa0555929d5a00f2d3c650 140 PRINTS PR00502 NUDIX hydrolase family signature 15 29 6.4E-6 T 09-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 TK78_RS08545 c2a9f6f36caa0555929d5a00f2d3c650 140 PRINTS PR00502 NUDIX hydrolase family signature 29 44 6.4E-6 T 09-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 TK78_RS08545 c2a9f6f36caa0555929d5a00f2d3c650 140 Gene3D G3DSA:3.90.79.10 4 62 1.1E-15 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS08545 c2a9f6f36caa0555929d5a00f2d3c650 140 SUPERFAMILY SSF55811 9 62 4.2E-15 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS08545 c2a9f6f36caa0555929d5a00f2d3c650 140 Pfam PF00293 NUDIX domain 11 50 6.1E-10 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS12720 5e671cd532bc3faaca485869e5a8630e 203 Pfam PF00072 Response regulator receiver domain 4 115 1.1E-25 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS12720 5e671cd532bc3faaca485869e5a8630e 203 Pfam PF00196 Bacterial regulatory proteins, luxR family 141 194 3.5E-18 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS12720 5e671cd532bc3faaca485869e5a8630e 203 SMART SM00448 2 115 4.9E-26 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS12720 5e671cd532bc3faaca485869e5a8630e 203 ProSitePatterns PS00622 LuxR-type HTH domain signature. 156 183 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS12720 5e671cd532bc3faaca485869e5a8630e 203 Gene3D G3DSA:1.10.10.10 144 201 7.9E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS12720 5e671cd532bc3faaca485869e5a8630e 203 SUPERFAMILY SSF46894 128 202 2.79E-20 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS12720 5e671cd532bc3faaca485869e5a8630e 203 SMART SM00421 139 196 1.2E-22 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS12720 5e671cd532bc3faaca485869e5a8630e 203 SUPERFAMILY SSF52172 1 127 1.37E-29 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS12720 5e671cd532bc3faaca485869e5a8630e 203 Gene3D G3DSA:3.40.50.2300 1 143 5.2E-34 T 09-03-2017 TK78_RS12720 5e671cd532bc3faaca485869e5a8630e 203 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 142 156 3.2E-12 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS12720 5e671cd532bc3faaca485869e5a8630e 203 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 156 172 3.2E-12 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS12720 5e671cd532bc3faaca485869e5a8630e 203 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 172 184 3.2E-12 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS20840 ef8e8e10576da646222c9169831875a8 257 PRINTS PR00162 Rieske 2Fe-2S subunit signature 110 121 6.1E-7 T 09-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 TK78_RS20840 ef8e8e10576da646222c9169831875a8 257 PRINTS PR00162 Rieske 2Fe-2S subunit signature 147 159 6.1E-7 T 09-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 TK78_RS20840 ef8e8e10576da646222c9169831875a8 257 PRINTS PR00162 Rieske 2Fe-2S subunit signature 134 146 6.1E-7 T 09-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 TK78_RS20840 ef8e8e10576da646222c9169831875a8 257 Gene3D G3DSA:2.102.10.10 32 178 1.5E-29 T 09-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 TK78_RS20840 ef8e8e10576da646222c9169831875a8 257 Pfam PF00355 Rieske [2Fe-2S] domain 98 161 4.2E-12 T 09-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 TK78_RS20840 ef8e8e10576da646222c9169831875a8 257 SUPERFAMILY SSF50022 82 174 7.73E-27 T 09-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 TK78_RS02590 b8b74d77d7830540a8d84b6655376d24 438 SUPERFAMILY SSF53850 30 429 4.73E-55 T 09-03-2017 TK78_RS02590 b8b74d77d7830540a8d84b6655376d24 438 Gene3D G3DSA:3.40.190.10 172 363 9.1E-46 T 09-03-2017 TK78_RS02590 b8b74d77d7830540a8d84b6655376d24 438 Pfam PF01547 Bacterial extracellular solute-binding protein 84 341 1.2E-27 T 09-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 TK78_RS02590 b8b74d77d7830540a8d84b6655376d24 438 Gene3D G3DSA:3.40.190.10 56 171 2.1E-12 T 09-03-2017 TK78_RS05725 069b904046da6c4e7c57543684119774 342 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 26 133 6.4E-31 T 09-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 TK78_RS05725 069b904046da6c4e7c57543684119774 342 Hamap MF_00627 L-threonine 3-dehydrogenase [tdh]. 1 340 56.214 T 09-03-2017 IPR004627 L-threonine 3-dehydrogenase GO:0006567|GO:0008270|GO:0008743|GO:0055114 KEGG: 00040+1.1.1.10|KEGG: 00260+1.1.1.103|MetaCyc: PWY-5515|MetaCyc: PWY-5525|MetaCyc: PWY-7378 TK78_RS05725 069b904046da6c4e7c57543684119774 342 SUPERFAMILY SSF50129 2 173 1.67E-49 T 09-03-2017 IPR011032 GroES-like TK78_RS05725 069b904046da6c4e7c57543684119774 342 SUPERFAMILY SSF51735 142 297 5.13E-30 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS05725 069b904046da6c4e7c57543684119774 342 Pfam PF00107 Zinc-binding dehydrogenase 174 301 6.1E-23 T 09-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 TK78_RS05725 069b904046da6c4e7c57543684119774 342 Gene3D G3DSA:3.90.180.10 2 172 1.3E-45 T 09-03-2017 IPR011032 GroES-like TK78_RS05725 069b904046da6c4e7c57543684119774 342 Gene3D G3DSA:3.40.50.720 173 287 4.9E-31 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS05725 069b904046da6c4e7c57543684119774 342 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 62 76 - T 09-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 TK78_RS14890 705c99e5f31499d6e753c3911e4ce082 190 Pfam PF04224 Protein of unknown function, DUF417 101 177 2.2E-5 T 09-03-2017 IPR007339 Protein of unknown function DUF417 TK78_RS00660 b7b456945cfbc47ec659a57079d7d411 376 SUPERFAMILY SSF52540 55 308 4.93E-21 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS00660 b7b456945cfbc47ec659a57079d7d411 376 Pfam PF07728 AAA domain (dynein-related subfamily) 80 226 1.0E-36 T 09-03-2017 IPR011704 ATPase, dynein-related, AAA domain GO:0005524|GO:0016887 TK78_RS00660 b7b456945cfbc47ec659a57079d7d411 376 Gene3D G3DSA:3.40.50.300 63 237 1.8E-19 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29690 15780b4f0babb73a2dd58efb8b1dafb9 286 SUPERFAMILY SSF51735 2 186 3.13E-49 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS29690 15780b4f0babb73a2dd58efb8b1dafb9 286 Gene3D G3DSA:3.40.50.720 3 190 9.6E-57 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS29690 15780b4f0babb73a2dd58efb8b1dafb9 286 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 7 186 1.3E-61 T 09-03-2017 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS29690 15780b4f0babb73a2dd58efb8b1dafb9 286 PIRSF PIRSF000105 2 286 1.4E-81 T 09-03-2017 IPR022694 3-hydroxyacyl-CoA dehydrogenase GO:0003857|GO:0006631|GO:0055114|GO:0070403 TK78_RS29690 15780b4f0babb73a2dd58efb8b1dafb9 286 Gene3D G3DSA:1.10.1040.10 191 285 1.3E-33 T 09-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 TK78_RS29690 15780b4f0babb73a2dd58efb8b1dafb9 286 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 189 285 2.1E-32 T 09-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS29690 15780b4f0babb73a2dd58efb8b1dafb9 286 SUPERFAMILY SSF48179 189 285 1.87E-30 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS15195 ae63fc33ebe72a8ee151351dba1ebe61 692 Gene3D G3DSA:3.60.20.10 327 502 1.1E-80 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS15195 ae63fc33ebe72a8ee151351dba1ebe61 692 Gene3D G3DSA:3.60.20.10 128 247 1.1E-80 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS15195 ae63fc33ebe72a8ee151351dba1ebe61 692 PIRSF PIRSF001227 1 689 1.6E-202 T 09-03-2017 IPR014395 Penicillin acylase GO:0016811 TK78_RS15195 ae63fc33ebe72a8ee151351dba1ebe61 692 Gene3D G3DSA:2.30.120.10 248 315 5.5E-10 T 09-03-2017 TK78_RS15195 ae63fc33ebe72a8ee151351dba1ebe61 692 Pfam PF01804 Penicillin amidase 3 680 1.4E-176 T 09-03-2017 IPR002692 Penicillin/cephalosporin acylase GO:0016787|GO:0017000 TK78_RS15195 ae63fc33ebe72a8ee151351dba1ebe61 692 Gene3D G3DSA:1.10.439.10 3 127 4.0E-36 T 09-03-2017 IPR023343 Penicillin amidase type, domain1 GO:0016811 TK78_RS15195 ae63fc33ebe72a8ee151351dba1ebe61 692 SUPERFAMILY SSF56235 3 680 2.83E-145 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS10225 16ef83acc6f72fbade692e16d10b773a 312 SUPERFAMILY SSF53686 19 299 1.37E-48 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS10225 16ef83acc6f72fbade692e16d10b773a 312 PIRSF PIRSF006278 2 308 1.4E-75 T 09-03-2017 IPR027278 1-aminocyclopropane-1-carboxylate deaminase/D-cysteine desulfhydrase TK78_RS10225 16ef83acc6f72fbade692e16d10b773a 312 Gene3D G3DSA:3.40.50.1100 108 299 2.5E-39 T 09-03-2017 TK78_RS10225 16ef83acc6f72fbade692e16d10b773a 312 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 19 299 3.3E-17 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS30225 d6858b2448cdf9814aa561409b7e5f8d 151 Pfam PF06103 Bacterial protein of unknown function (DUF948) 1 81 8.5E-12 T 09-03-2017 IPR009293 Uncharacterised protein family UPF0478 TK78_RS28235 5bcfd1cbdd14df2ae2ec66a7895c96be 572 SUPERFAMILY SSF52317 193 239 2.72E-35 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS28235 5bcfd1cbdd14df2ae2ec66a7895c96be 572 SUPERFAMILY SSF52317 274 424 2.72E-35 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS28235 5bcfd1cbdd14df2ae2ec66a7895c96be 572 Gene3D G3DSA:3.40.50.880 262 438 9.3E-38 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS28235 5bcfd1cbdd14df2ae2ec66a7895c96be 572 Gene3D G3DSA:3.40.50.300 5 237 1.1E-41 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28235 5bcfd1cbdd14df2ae2ec66a7895c96be 572 Pfam PF01656 CobQ/CobB/MinD/ParA nucleotide binding domain 6 213 2.7E-24 T 09-03-2017 IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain TK78_RS28235 5bcfd1cbdd14df2ae2ec66a7895c96be 572 SUPERFAMILY SSF52540 1 241 9.18E-51 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28235 5bcfd1cbdd14df2ae2ec66a7895c96be 572 Hamap MF_00028 Cobyric acid synthase [cobQ]. 1 488 170.543 T 09-03-2017 IPR004459 Cobyric acid synthase CobQ GO:0003824|GO:0009236 TK78_RS28235 5bcfd1cbdd14df2ae2ec66a7895c96be 572 TIGRFAM TIGR00313 cobQ: cobyric acid synthase CobQ 5 479 2.4E-137 T 09-03-2017 IPR004459 Cobyric acid synthase CobQ GO:0003824|GO:0009236 TK78_RS28235 5bcfd1cbdd14df2ae2ec66a7895c96be 572 Pfam PF07685 CobB/CobQ-like glutamine amidotransferase domain 262 432 1.6E-42 T 09-03-2017 IPR011698 CobB/CobQ-like glutamine amidotransferase GO:0003824|GO:0009236 TK78_RS34610 2f5bf89412e32df89e7f127031438bc7 116 Pfam PF13340 Putative transposase of IS4/5 family (DUF4096) 10 86 1.4E-20 T 09-03-2017 IPR025161 Putative transposase IS4/IS5 family TK78_RS27170 b951314fcaf5b9703f87f64311a66d94 528 TIGRFAM TIGR00831 a_cpa1: Na+/H+ antiporter 8 525 5.1E-95 T 09-03-2017 IPR004705 Cation/H+ exchanger, CPA1 family, bacteria GO:0006812|GO:0015299|GO:0016021 TK78_RS27170 b951314fcaf5b9703f87f64311a66d94 528 Pfam PF00999 Sodium/hydrogen exchanger family 10 406 9.7E-54 T 09-03-2017 IPR006153 Cation/H+ exchanger GO:0006812|GO:0015299|GO:0016021|GO:0055085 TK78_RS12415 ba39fcb774ffca35bc5aa8dd8e16c735 455 SUPERFAMILY SSF56176 7 179 1.92E-30 T 09-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 TK78_RS12415 ba39fcb774ffca35bc5aa8dd8e16c735 455 Gene3D G3DSA:3.30.465.10 77 178 9.4E-19 T 09-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 TK78_RS12415 ba39fcb774ffca35bc5aa8dd8e16c735 455 Pfam PF04030 D-arabinono-1,4-lactone oxidase 401 452 1.3E-4 T 09-03-2017 IPR007173 D-arabinono-1,4-lactone oxidase GO:0003885|GO:0016020|GO:0055114 TK78_RS12415 ba39fcb774ffca35bc5aa8dd8e16c735 455 Pfam PF01565 FAD binding domain 21 151 5.4E-19 T 09-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 TK78_RS05720 d7c1551b569953aee22d619efb985f25 400 Gene3D G3DSA:3.90.1150.10 280 391 2.7E-29 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS05720 d7c1551b569953aee22d619efb985f25 400 Pfam PF00155 Aminotransferase class I and II 46 388 1.2E-68 T 09-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TK78_RS05720 d7c1551b569953aee22d619efb985f25 400 TIGRFAM TIGR01822 2am3keto_CoA: glycine C-acetyltransferase 6 391 1.1E-193 T 09-03-2017 IPR011282 2-amino-3-ketobutyrate coenzyme A ligase GO:0006567|GO:0008890 KEGG: 00260+2.3.1.29|Reactome: R-HSA-8849175 TK78_RS05720 d7c1551b569953aee22d619efb985f25 400 Gene3D G3DSA:3.40.640.10 63 279 4.4E-89 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS05720 d7c1551b569953aee22d619efb985f25 400 Hamap MF_00985 2-amino-3-ketobutyrate coenzyme A ligase [kbl]. 2 396 54.052 T 09-03-2017 IPR011282 2-amino-3-ketobutyrate coenzyme A ligase GO:0006567|GO:0008890 KEGG: 00260+2.3.1.29|Reactome: R-HSA-8849175 TK78_RS05720 d7c1551b569953aee22d619efb985f25 400 SUPERFAMILY SSF53383 7 392 8.68E-117 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS05720 d7c1551b569953aee22d619efb985f25 400 ProSitePatterns PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 242 251 - T 09-03-2017 IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site GO:0008152|GO:0016740 TK78_RS03005 6f92fefbf14d314b9119d8dde9a0b685 144 SUPERFAMILY SSF103196 5 133 1.19E-25 T 09-03-2017 TK78_RS03005 6f92fefbf14d314b9119d8dde9a0b685 144 Gene3D G3DSA:3.30.450.30 5 129 6.7E-21 T 09-03-2017 TK78_RS03005 6f92fefbf14d314b9119d8dde9a0b685 144 SMART SM00960 14 104 6.6E-25 T 09-03-2017 IPR004942 Roadblock/LAMTOR2 domain TK78_RS03005 6f92fefbf14d314b9119d8dde9a0b685 144 Pfam PF03259 Roadblock/LC7 domain 13 104 2.8E-24 T 09-03-2017 IPR004942 Roadblock/LAMTOR2 domain TK78_RS03475 e12cfe4589445a5bae974e2a564a1ef3 403 Pfam PF11887 Cholesterol uptake porter CUP1 of Mce4, putative 180 301 6.7E-8 T 09-03-2017 IPR024516 Mammalian cell entry, C-terminal TK78_RS03475 e12cfe4589445a5bae974e2a564a1ef3 403 TIGRFAM TIGR00996 Mtu_fam_mce: virulence factor Mce family protein 38 318 8.5E-67 T 09-03-2017 IPR005693 Virulence factor Mce protein TK78_RS03475 e12cfe4589445a5bae974e2a564a1ef3 403 Pfam PF02470 MlaD protein 56 133 9.0E-20 T 09-03-2017 IPR003399 Mce/MlaD TK78_RS14035 60c9009f66b6a6475696ed3ef0f07f55 423 SUPERFAMILY SSF53822 67 378 3.12E-30 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS14035 60c9009f66b6a6475696ed3ef0f07f55 423 Gene3D G3DSA:3.40.50.2300 67 164 3.9E-18 T 09-03-2017 TK78_RS14035 60c9009f66b6a6475696ed3ef0f07f55 423 Gene3D G3DSA:3.40.50.2300 308 375 3.9E-18 T 09-03-2017 TK78_RS14035 60c9009f66b6a6475696ed3ef0f07f55 423 Pfam PF13458 Periplasmic binding protein 67 374 5.5E-31 T 09-03-2017 IPR028081 Leucine-binding protein domain TK78_RS06755 16afe938b22234afe1131b14c028508e 73 SMART SM00923 4 54 5.7E-33 T 09-03-2017 IPR005153 MbtH-like protein TK78_RS06755 16afe938b22234afe1131b14c028508e 73 SUPERFAMILY SSF160582 3 70 1.44E-29 T 09-03-2017 TK78_RS06755 16afe938b22234afe1131b14c028508e 73 Gene3D G3DSA:3.90.820.10 11 70 3.0E-29 T 09-03-2017 TK78_RS06755 16afe938b22234afe1131b14c028508e 73 Pfam PF03621 MbtH-like protein 3 53 3.5E-27 T 09-03-2017 IPR005153 MbtH-like protein TK78_RS12045 5805c9e2071628e7aa4357781572fef3 212 Pfam PF10756 Bacterial PH domain 69 137 2.3E-9 T 09-03-2017 IPR019692 Protein of unknown function DUF2581 TK78_RS22715 a17688b4864196e39af08257a064f989 767 Gene3D G3DSA:3.40.710.10 282 686 5.7E-93 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS22715 a17688b4864196e39af08257a064f989 767 SUPERFAMILY SSF56601 314 683 7.3E-77 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS22715 a17688b4864196e39af08257a064f989 767 SUPERFAMILY SSF56601 266 285 7.3E-77 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS22715 a17688b4864196e39af08257a064f989 767 Pfam PF00912 Transglycosylase 107 281 1.2E-58 T 09-03-2017 IPR001264 Glycosyl transferase, family 51 TK78_RS22715 a17688b4864196e39af08257a064f989 767 Pfam PF00905 Penicillin binding protein transpeptidase domain 385 640 5.1E-26 T 09-03-2017 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 TK78_RS22715 a17688b4864196e39af08257a064f989 767 SUPERFAMILY SSF53955 95 295 2.56E-63 T 09-03-2017 IPR023346 Lysozyme-like domain TK78_RS22715 a17688b4864196e39af08257a064f989 767 Gene3D G3DSA:1.10.3810.10 105 281 9.3E-65 T 09-03-2017 TK78_RS02140 4699495729910c7b1f6786d3f7ced539 475 Gene3D G3DSA:3.90.1580.10 203 474 6.0E-72 T 09-03-2017 IPR005532 Sulfatase-modifying factor enzyme Reactome: R-HSA-1660662|Reactome: R-HSA-1663150 TK78_RS02140 4699495729910c7b1f6786d3f7ced539 475 TIGRFAM TIGR03440 egtB_TIGR03440: ergothioneine biosynthesis protein EgtB 53 472 8.9E-137 T 09-03-2017 IPR017806 Ergothioneine biosynthesis protein EgtB GO:0052699 KEGG: 00340+1.14.99.50|MetaCyc: PWY-7255 TK78_RS02140 4699495729910c7b1f6786d3f7ced539 475 SUPERFAMILY SSF56436 215 474 6.78E-71 T 09-03-2017 IPR016187 C-type lectin fold TK78_RS02140 4699495729910c7b1f6786d3f7ced539 475 Pfam PF12867 DinB superfamily 55 187 4.2E-27 T 09-03-2017 IPR024775 DinB-like domain TK78_RS02140 4699495729910c7b1f6786d3f7ced539 475 Gene3D G3DSA:1.20.120.450 49 166 4.4E-8 T 09-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase TK78_RS02140 4699495729910c7b1f6786d3f7ced539 475 SUPERFAMILY SSF109854 48 183 2.72E-20 T 09-03-2017 TK78_RS02140 4699495729910c7b1f6786d3f7ced539 475 Hamap MF_02035 Hercynine oxygenase [egtB]. 28 475 51.958 T 09-03-2017 IPR032890 Hercynine oxygenase, Actinobacteria GO:0016491|GO:0052699 KEGG: 00340+1.14.99.50|MetaCyc: PWY-7255 TK78_RS02140 4699495729910c7b1f6786d3f7ced539 475 Pfam PF03781 Sulfatase-modifying factor enzyme 1 214 473 6.3E-60 T 09-03-2017 IPR005532 Sulfatase-modifying factor enzyme Reactome: R-HSA-1660662|Reactome: R-HSA-1663150 TK78_RS08200 1a232bb23540f58f46e8eebed026b0bd 450 TIGRFAM TIGR00836 amt: ammonium transporter 19 419 1.1E-137 T 09-03-2017 IPR001905 Ammonium transporter GO:0008519|GO:0016020|GO:0072488 TK78_RS08200 1a232bb23540f58f46e8eebed026b0bd 450 SUPERFAMILY SSF111352 16 400 1.24E-123 T 09-03-2017 IPR024041 Ammonium transporter AmtB-like domain GO:0008519|GO:0015696|GO:0016020 TK78_RS08200 1a232bb23540f58f46e8eebed026b0bd 450 Gene3D G3DSA:1.10.3430.10 15 400 6.4E-136 T 09-03-2017 IPR029020 Ammonium/urea transporter TK78_RS08200 1a232bb23540f58f46e8eebed026b0bd 450 ProSitePatterns PS01219 Ammonium transporters signature. 174 199 - T 09-03-2017 IPR018047 Ammonium transporter, conserved site GO:0008519|GO:0016020|GO:0072488 TK78_RS08200 1a232bb23540f58f46e8eebed026b0bd 450 Pfam PF00909 Ammonium Transporter Family 22 419 1.3E-128 T 09-03-2017 IPR024041 Ammonium transporter AmtB-like domain GO:0008519|GO:0015696|GO:0016020 TK78_RS01505 33ac459e1f2c305bec7c7e1201fae35b 538 Gene3D G3DSA:3.10.105.10 288 491 1.6E-44 T 09-03-2017 TK78_RS01505 33ac459e1f2c305bec7c7e1201fae35b 538 Gene3D G3DSA:3.40.190.10 141 287 1.3E-38 T 09-03-2017 TK78_RS01505 33ac459e1f2c305bec7c7e1201fae35b 538 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 79 437 2.3E-86 T 09-03-2017 IPR000914 Solute-binding protein family 5 domain TK78_RS01505 33ac459e1f2c305bec7c7e1201fae35b 538 PIRSF PIRSF002741 1 525 3.5E-103 T 09-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 TK78_RS01505 33ac459e1f2c305bec7c7e1201fae35b 538 SUPERFAMILY SSF53850 43 507 9.05E-116 T 09-03-2017 TK78_RS18130 b36c16a239f3833b10dc3b91ff92015f 108 Pfam PF13673 Acetyltransferase (GNAT) domain 32 95 2.0E-7 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS18130 b36c16a239f3833b10dc3b91ff92015f 108 Gene3D G3DSA:3.40.630.30 30 106 1.9E-11 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS18130 b36c16a239f3833b10dc3b91ff92015f 108 SUPERFAMILY SSF55729 25 91 5.23E-12 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS27035 6bf7e86ca18808a26bfd243b0d05e47b 134 Pfam PF11239 Protein of unknown function (DUF3040) 1 80 8.1E-29 T 09-03-2017 IPR021401 Protein of unknown function DUF3040 TK78_RS31690 bcc7d3be7883d3b1a4b321c75fea3e42 162 PIRSF PIRSF000303 1 161 2.2E-59 T 09-03-2017 IPR000889 Glutathione peroxidase GO:0004602|GO:0006979|GO:0055114 Reactome: R-HSA-3299685 TK78_RS31690 bcc7d3be7883d3b1a4b321c75fea3e42 162 Gene3D G3DSA:3.40.30.10 1 160 7.3E-59 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS31690 bcc7d3be7883d3b1a4b321c75fea3e42 162 Pfam PF00255 Glutathione peroxidase 4 109 3.9E-38 T 09-03-2017 IPR000889 Glutathione peroxidase GO:0004602|GO:0006979|GO:0055114 Reactome: R-HSA-3299685 TK78_RS31690 bcc7d3be7883d3b1a4b321c75fea3e42 162 ProSitePatterns PS00460 Glutathione peroxidases active site. 23 38 - T 09-03-2017 IPR029759 Glutathione peroxidase active site Reactome: R-HSA-3299685 TK78_RS31690 bcc7d3be7883d3b1a4b321c75fea3e42 162 SUPERFAMILY SSF52833 1 160 2.28E-53 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS31690 bcc7d3be7883d3b1a4b321c75fea3e42 162 PRINTS PR01011 Glutathione peroxidase family signature 122 131 1.7E-18 T 09-03-2017 IPR000889 Glutathione peroxidase GO:0004602|GO:0006979|GO:0055114 Reactome: R-HSA-3299685 TK78_RS31690 bcc7d3be7883d3b1a4b321c75fea3e42 162 PRINTS PR01011 Glutathione peroxidase family signature 21 38 1.7E-18 T 09-03-2017 IPR000889 Glutathione peroxidase GO:0004602|GO:0006979|GO:0055114 Reactome: R-HSA-3299685 TK78_RS31690 bcc7d3be7883d3b1a4b321c75fea3e42 162 PRINTS PR01011 Glutathione peroxidase family signature 56 72 1.7E-18 T 09-03-2017 IPR000889 Glutathione peroxidase GO:0004602|GO:0006979|GO:0055114 Reactome: R-HSA-3299685 TK78_RS07880 e17ba0caa17d446ce278e081b4b0a637 417 SUPERFAMILY SSF51735 22 172 1.4E-36 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07880 e17ba0caa17d446ce278e081b4b0a637 417 Pfam PF08436 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal 168 251 1.9E-36 T 09-03-2017 IPR013644 1-deoxy-D-xylulose 5-phosphate reductoisomerase, C-terminal GO:0005515 KEGG: 00630+1.1.1.26|KEGG: 00900+1.1.1.267|MetaCyc: PWY-7294|MetaCyc: PWY-7295|MetaCyc: PWY-7560 TK78_RS07880 e17ba0caa17d446ce278e081b4b0a637 417 Gene3D G3DSA:3.40.50.720 19 172 2.0E-52 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07880 e17ba0caa17d446ce278e081b4b0a637 417 TIGRFAM TIGR00243 Dxr: 1-deoxy-D-xylulose 5-phosphate reductoisomerase 23 410 3.5E-112 T 09-03-2017 IPR003821 1-deoxy-D-xylulose 5-phosphate reductoisomerase GO:0008299|GO:0030604|GO:0046872|GO:0055114 KEGG: 00630+1.1.1.26|KEGG: 00900+1.1.1.267|MetaCyc: PWY-7294|MetaCyc: PWY-7295|MetaCyc: PWY-7560 TK78_RS07880 e17ba0caa17d446ce278e081b4b0a637 417 Pfam PF13288 DXP reductoisomerase C-terminal domain 285 402 2.5E-29 T 09-03-2017 IPR026877 DXP reductoisomerase C-terminal domain KEGG: 00630+1.1.1.26|KEGG: 00900+1.1.1.267|MetaCyc: PWY-7294|MetaCyc: PWY-7295|MetaCyc: PWY-7560 TK78_RS07880 e17ba0caa17d446ce278e081b4b0a637 417 SUPERFAMILY SSF55347 150 286 4.9E-53 T 09-03-2017 TK78_RS07880 e17ba0caa17d446ce278e081b4b0a637 417 Hamap MF_00183 1-deoxy-D-xylulose 5-phosphate reductoisomerase [dxr]. 24 407 43.672 T 09-03-2017 IPR003821 1-deoxy-D-xylulose 5-phosphate reductoisomerase GO:0008299|GO:0030604|GO:0046872|GO:0055114 KEGG: 00630+1.1.1.26|KEGG: 00900+1.1.1.267|MetaCyc: PWY-7294|MetaCyc: PWY-7295|MetaCyc: PWY-7560 TK78_RS07880 e17ba0caa17d446ce278e081b4b0a637 417 Gene3D G3DSA:1.10.1740.10 325 408 1.1E-28 T 09-03-2017 TK78_RS07880 e17ba0caa17d446ce278e081b4b0a637 417 Pfam PF02670 1-deoxy-D-xylulose 5-phosphate reductoisomerase 24 156 6.5E-40 T 09-03-2017 IPR013512 1-deoxy-D-xylulose 5-phosphate reductoisomerase, N-terminal GO:0055114|GO:0070402 KEGG: 00630+1.1.1.26|KEGG: 00900+1.1.1.267|MetaCyc: PWY-7294|MetaCyc: PWY-7295|MetaCyc: PWY-7560 TK78_RS07880 e17ba0caa17d446ce278e081b4b0a637 417 PIRSF PIRSF006205 21 414 1.4E-139 T 09-03-2017 IPR003821 1-deoxy-D-xylulose 5-phosphate reductoisomerase GO:0008299|GO:0030604|GO:0046872|GO:0055114 KEGG: 00630+1.1.1.26|KEGG: 00900+1.1.1.267|MetaCyc: PWY-7294|MetaCyc: PWY-7295|MetaCyc: PWY-7560 TK78_RS07880 e17ba0caa17d446ce278e081b4b0a637 417 SUPERFAMILY SSF69055 314 408 2.75E-25 T 09-03-2017 IPR026877 DXP reductoisomerase C-terminal domain KEGG: 00630+1.1.1.26|KEGG: 00900+1.1.1.267|MetaCyc: PWY-7294|MetaCyc: PWY-7295|MetaCyc: PWY-7560 TK78_RS25005 8baf857bc9fd8026c4f14b4338f0ea38 299 Gene3D G3DSA:3.90.1200.10 107 269 1.0E-31 T 09-03-2017 TK78_RS25005 8baf857bc9fd8026c4f14b4338f0ea38 299 Pfam PF01636 Phosphotransferase enzyme family 51 258 1.8E-30 T 09-03-2017 IPR002575 Aminoglycoside phosphotransferase TK78_RS25005 8baf857bc9fd8026c4f14b4338f0ea38 299 SUPERFAMILY SSF56112 21 270 2.04E-44 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS06965 2705b84f367754d39604c6b3c8be9537 258 SUPERFAMILY SSF54593 142 253 1.06E-17 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS06965 2705b84f367754d39604c6b3c8be9537 258 SUPERFAMILY SSF54593 13 125 1.61E-15 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS06965 2705b84f367754d39604c6b3c8be9537 258 Gene3D G3DSA:3.10.180.10 140 253 2.4E-28 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS06965 2705b84f367754d39604c6b3c8be9537 258 Gene3D G3DSA:3.10.180.10 12 125 3.0E-28 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS13590 2b2315b1109bd7c8c40a6aad2ecb3a48 203 Pfam PF05685 Putative restriction endonuclease 23 190 2.2E-28 T 09-03-2017 IPR008538 Domain of unknown function DUF820 TK78_RS13590 2b2315b1109bd7c8c40a6aad2ecb3a48 203 SUPERFAMILY SSF52980 15 174 4.61E-20 T 09-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 TK78_RS13590 2b2315b1109bd7c8c40a6aad2ecb3a48 203 Gene3D G3DSA:3.90.1570.10 15 163 1.1E-19 T 09-03-2017 IPR012296 Nuclease, putative, TT1808 TK78_RS15040 63a8270e07b0102c6b1c733b633358b6 214 SMART SM00421 148 210 2.0E-14 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS15040 63a8270e07b0102c6b1c733b633358b6 214 Gene3D G3DSA:3.40.50.2300 1 152 2.6E-22 T 09-03-2017 TK78_RS15040 63a8270e07b0102c6b1c733b633358b6 214 Pfam PF00196 Bacterial regulatory proteins, luxR family 150 195 2.4E-12 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS15040 63a8270e07b0102c6b1c733b633358b6 214 Pfam PF00072 Response regulator receiver domain 4 97 2.5E-10 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS15040 63a8270e07b0102c6b1c733b633358b6 214 ProSitePatterns PS00622 LuxR-type HTH domain signature. 165 192 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS15040 63a8270e07b0102c6b1c733b633358b6 214 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 151 165 1.1E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS15040 63a8270e07b0102c6b1c733b633358b6 214 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 165 181 1.1E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS15040 63a8270e07b0102c6b1c733b633358b6 214 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 181 193 1.1E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS15040 63a8270e07b0102c6b1c733b633358b6 214 Gene3D G3DSA:1.10.10.10 153 212 2.5E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS15040 63a8270e07b0102c6b1c733b633358b6 214 SUPERFAMILY SSF52172 1 169 5.39E-18 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS15040 63a8270e07b0102c6b1c733b633358b6 214 SMART SM00448 2 122 4.9E-6 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS02200 960d4cb1239ff137c540a73fc412d00e 649 Gene3D G3DSA:3.50.50.60 409 461 1.1E-77 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS02200 960d4cb1239ff137c540a73fc412d00e 649 Gene3D G3DSA:3.50.50.60 38 277 1.1E-77 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS02200 960d4cb1239ff137c540a73fc412d00e 649 SUPERFAMILY SSF51905 417 463 3.05E-50 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS02200 960d4cb1239ff137c540a73fc412d00e 649 SUPERFAMILY SSF51905 38 288 3.05E-50 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS02200 960d4cb1239ff137c540a73fc412d00e 649 TIGRFAM TIGR01811 sdhA_Bsu: succinate dehydrogenase or fumarate reductase, flavoprotein subunit 47 648 0.0 T 09-03-2017 IPR011280 Succinate dehydrogenase/fumarate reductase flavoprotein subunit, low-GC Gram-positive bacteria KEGG: 00020+1.3.5.1|KEGG: 00190+1.3.5.1|KEGG: 00650+1.3.5.1|KEGG: 00720+1.3.5.1|MetaCyc: PWY-3781|MetaCyc: PWY-4302|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7279 TK78_RS02200 960d4cb1239ff137c540a73fc412d00e 649 Pfam PF00890 FAD binding domain 47 452 6.8E-62 T 09-03-2017 IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS02200 960d4cb1239ff137c540a73fc412d00e 649 Gene3D G3DSA:3.90.700.10 278 407 6.3E-19 T 09-03-2017 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS02200 960d4cb1239ff137c540a73fc412d00e 649 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 47 66 1.2E-6 T 09-03-2017 TK78_RS02200 960d4cb1239ff137c540a73fc412d00e 649 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 416 438 1.2E-6 T 09-03-2017 TK78_RS02200 960d4cb1239ff137c540a73fc412d00e 649 SUPERFAMILY SSF46977 505 648 8.24E-40 T 09-03-2017 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS02200 960d4cb1239ff137c540a73fc412d00e 649 Pfam PF02910 Fumarate reductase flavoprotein C-term 514 648 2.3E-35 T 09-03-2017 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS02200 960d4cb1239ff137c540a73fc412d00e 649 Gene3D G3DSA:1.20.58.100 486 603 5.0E-32 T 09-03-2017 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS02200 960d4cb1239ff137c540a73fc412d00e 649 SUPERFAMILY SSF56425 272 414 9.12E-34 T 09-03-2017 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS28620 7cafdd928dbf10732b78311ece004546 268 Gene3D G3DSA:3.30.470.10 28 90 2.9E-4 T 09-03-2017 TK78_RS28620 7cafdd928dbf10732b78311ece004546 268 Pfam PF01063 Amino-transferase class IV 31 241 3.2E-29 T 09-03-2017 IPR001544 Aminotransferase class IV GO:0003824|GO:0008152 Reactome: R-HSA-70895 TK78_RS28620 7cafdd928dbf10732b78311ece004546 268 Gene3D G3DSA:3.20.10.10 128 248 4.9E-16 T 09-03-2017 TK78_RS28620 7cafdd928dbf10732b78311ece004546 268 SUPERFAMILY SSF56752 18 247 1.16E-34 T 09-03-2017 IPR001544 Aminotransferase class IV GO:0003824|GO:0008152 Reactome: R-HSA-70895 TK78_RS30980 9aef70581dadc785ae43ee2eef48840b 333 SUPERFAMILY SSF46785 262 326 8.75E-7 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS30980 9aef70581dadc785ae43ee2eef48840b 333 Pfam PF12840 Helix-turn-helix domain 261 307 5.0E-7 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS30980 9aef70581dadc785ae43ee2eef48840b 333 Gene3D G3DSA:1.10.10.10 261 323 2.2E-7 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS24910 c01f0ff20bc23da06069ff978485aa88 460 TIGRFAM TIGR00389 glyS_dimeric: glycine--tRNA ligase 6 229 1.1E-81 T 09-03-2017 IPR002315 Glycyl-tRNA synthetase GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14|Reactome: R-HSA-379716|Reactome: R-HSA-379726 TK78_RS24910 c01f0ff20bc23da06069ff978485aa88 460 Gene3D G3DSA:3.30.930.10 7 361 2.8E-141 T 09-03-2017 TK78_RS24910 c01f0ff20bc23da06069ff978485aa88 460 Gene3D G3DSA:3.40.50.800 362 455 3.4E-40 T 09-03-2017 IPR004154 Anticodon-binding TK78_RS24910 c01f0ff20bc23da06069ff978485aa88 460 Pfam PF03129 Anticodon binding domain 366 453 4.7E-23 T 09-03-2017 IPR004154 Anticodon-binding TK78_RS24910 c01f0ff20bc23da06069ff978485aa88 460 SUPERFAMILY SSF55681 5 369 1.06E-118 T 09-03-2017 TK78_RS24910 c01f0ff20bc23da06069ff978485aa88 460 Pfam PF00587 tRNA synthetase class II core domain (G, H, P, S and T) 157 333 3.4E-9 T 09-03-2017 IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS24910 c01f0ff20bc23da06069ff978485aa88 460 Hamap MF_00253_B Glycine--tRNA ligase [glyQS]. 3 458 49.315 T 09-03-2017 IPR022961 Glycine-tRNA ligase, bacterial GO:0004820 KEGG: 00970+6.1.1.14 TK78_RS24910 c01f0ff20bc23da06069ff978485aa88 460 SUPERFAMILY SSF52954 353 455 1.31E-33 T 09-03-2017 IPR004154 Anticodon-binding TK78_RS24910 c01f0ff20bc23da06069ff978485aa88 460 PRINTS PR01043 Glycyl-tRNA synthetase signature 403 422 2.2E-51 T 09-03-2017 IPR002315 Glycyl-tRNA synthetase GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14|Reactome: R-HSA-379716|Reactome: R-HSA-379726 TK78_RS24910 c01f0ff20bc23da06069ff978485aa88 460 PRINTS PR01043 Glycyl-tRNA synthetase signature 317 329 2.2E-51 T 09-03-2017 IPR002315 Glycyl-tRNA synthetase GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14|Reactome: R-HSA-379716|Reactome: R-HSA-379726 TK78_RS24910 c01f0ff20bc23da06069ff978485aa88 460 PRINTS PR01043 Glycyl-tRNA synthetase signature 158 175 2.2E-51 T 09-03-2017 IPR002315 Glycyl-tRNA synthetase GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14|Reactome: R-HSA-379716|Reactome: R-HSA-379726 TK78_RS24910 c01f0ff20bc23da06069ff978485aa88 460 PRINTS PR01043 Glycyl-tRNA synthetase signature 190 207 2.2E-51 T 09-03-2017 IPR002315 Glycyl-tRNA synthetase GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14|Reactome: R-HSA-379716|Reactome: R-HSA-379726 TK78_RS24910 c01f0ff20bc23da06069ff978485aa88 460 PRINTS PR01043 Glycyl-tRNA synthetase signature 137 149 2.2E-51 T 09-03-2017 IPR002315 Glycyl-tRNA synthetase GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14|Reactome: R-HSA-379716|Reactome: R-HSA-379726 TK78_RS24910 c01f0ff20bc23da06069ff978485aa88 460 PRINTS PR01043 Glycyl-tRNA synthetase signature 25 39 2.2E-51 T 09-03-2017 IPR002315 Glycyl-tRNA synthetase GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14|Reactome: R-HSA-379716|Reactome: R-HSA-379726 TK78_RS24910 c01f0ff20bc23da06069ff978485aa88 460 PRINTS PR01043 Glycyl-tRNA synthetase signature 207 217 2.2E-51 T 09-03-2017 IPR002315 Glycyl-tRNA synthetase GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14|Reactome: R-HSA-379716|Reactome: R-HSA-379726 TK78_RS10785 499239996dbf187257c1bc51e5947254 229 Gene3D G3DSA:1.10.1740.10 44 137 8.5E-27 T 09-03-2017 TK78_RS10785 499239996dbf187257c1bc51e5947254 229 SUPERFAMILY SSF88946 45 127 3.61E-24 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS10785 499239996dbf187257c1bc51e5947254 229 SUPERFAMILY SSF88659 146 204 2.24E-17 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS10785 499239996dbf187257c1bc51e5947254 229 Pfam PF04542 Sigma-70 region 2 50 115 1.2E-20 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS10785 499239996dbf187257c1bc51e5947254 229 Gene3D G3DSA:1.10.10.10 143 205 3.2E-25 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS10785 499239996dbf187257c1bc51e5947254 229 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 46 203 8.2E-33 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS10785 499239996dbf187257c1bc51e5947254 229 Pfam PF08281 Sigma-70, region 4 148 199 6.1E-17 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS05655 03b4098869b59946be40a8ec2ac2bb71 325 Pfam PF00583 Acetyltransferase (GNAT) family 233 305 2.4E-8 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS05655 03b4098869b59946be40a8ec2ac2bb71 325 SUPERFAMILY SSF55729 44 313 3.28E-19 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS05655 03b4098869b59946be40a8ec2ac2bb71 325 Gene3D G3DSA:3.40.630.30 203 318 2.3E-12 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS32490 2761d60c5701df09d8b23db063f6d2c2 264 SMART SM00345 49 110 4.4E-12 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS32490 2761d60c5701df09d8b23db063f6d2c2 264 SUPERFAMILY SSF46785 42 114 2.55E-16 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32490 2761d60c5701df09d8b23db063f6d2c2 264 Pfam PF07729 FCD domain 135 251 5.5E-18 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS32490 2761d60c5701df09d8b23db063f6d2c2 264 Gene3D G3DSA:1.10.10.10 46 114 1.6E-18 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32490 2761d60c5701df09d8b23db063f6d2c2 264 SUPERFAMILY SSF48008 131 262 1.33E-21 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS32490 2761d60c5701df09d8b23db063f6d2c2 264 Gene3D G3DSA:1.20.120.530 131 261 9.7E-20 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS32490 2761d60c5701df09d8b23db063f6d2c2 264 Pfam PF00392 Bacterial regulatory proteins, gntR family 48 110 6.5E-13 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS32490 2761d60c5701df09d8b23db063f6d2c2 264 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 82 98 2.9E-7 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS32490 2761d60c5701df09d8b23db063f6d2c2 264 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 68 82 2.9E-7 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS32490 2761d60c5701df09d8b23db063f6d2c2 264 SMART SM00895 134 254 4.6E-15 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS15440 f142ebe316a20b1fcb2ecedd355f8472 156 Gene3D G3DSA:3.30.1330.40 4 153 2.1E-68 T 09-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like TK78_RS15440 f142ebe316a20b1fcb2ecedd355f8472 156 Pfam PF14588 YjgF/chorismate_mutase-like, putative endoribonuclease 6 152 5.0E-34 T 09-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like TK78_RS15440 f142ebe316a20b1fcb2ecedd355f8472 156 SUPERFAMILY SSF55298 5 153 2.36E-56 T 09-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like TK78_RS10410 ab5b29ed73961a2d856254462303c6df 366 Gene3D G3DSA:1.20.1250.20 184 354 5.6E-13 T 09-03-2017 TK78_RS10410 ab5b29ed73961a2d856254462303c6df 366 Gene3D G3DSA:1.20.1250.20 9 155 7.4E-21 T 09-03-2017 TK78_RS10410 ab5b29ed73961a2d856254462303c6df 366 Pfam PF07690 Major Facilitator Superfamily 9 282 1.8E-25 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS10410 ab5b29ed73961a2d856254462303c6df 366 SUPERFAMILY SSF103473 9 355 2.35E-42 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS26710 35f561e3defca9d942088a0459cb1d23 242 Gene3D G3DSA:1.10.10.10 176 236 2.4E-25 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS26710 35f561e3defca9d942088a0459cb1d23 242 SMART SM00448 17 132 6.0E-29 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS26710 35f561e3defca9d942088a0459cb1d23 242 SUPERFAMILY SSF46894 168 237 4.76E-21 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS26710 35f561e3defca9d942088a0459cb1d23 242 Gene3D G3DSA:3.40.50.2300 15 175 3.9E-37 T 09-03-2017 TK78_RS26710 35f561e3defca9d942088a0459cb1d23 242 ProSitePatterns PS00622 LuxR-type HTH domain signature. 191 218 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS26710 35f561e3defca9d942088a0459cb1d23 242 SMART SM00421 174 231 3.2E-23 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS26710 35f561e3defca9d942088a0459cb1d23 242 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 191 207 8.9E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS26710 35f561e3defca9d942088a0459cb1d23 242 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 177 191 8.9E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS26710 35f561e3defca9d942088a0459cb1d23 242 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 207 219 8.9E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS26710 35f561e3defca9d942088a0459cb1d23 242 Pfam PF00072 Response regulator receiver domain 19 133 1.5E-25 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS26710 35f561e3defca9d942088a0459cb1d23 242 SUPERFAMILY SSF52172 15 143 2.99E-32 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS26710 35f561e3defca9d942088a0459cb1d23 242 Pfam PF00196 Bacterial regulatory proteins, luxR family 176 231 8.0E-17 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS14840 005dc7143e8bc11bdcb8d8549cee7fb3 149 SUPERFAMILY SSF52172 6 130 1.2E-26 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS14840 005dc7143e8bc11bdcb8d8549cee7fb3 149 SMART SM00448 5 122 1.2E-18 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS14840 005dc7143e8bc11bdcb8d8549cee7fb3 149 Gene3D G3DSA:3.40.50.2300 7 128 7.3E-29 T 09-03-2017 TK78_RS14840 005dc7143e8bc11bdcb8d8549cee7fb3 149 Pfam PF00072 Response regulator receiver domain 7 120 2.3E-19 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS25160 fd79f8de7f1eaf5ac575b56a60e08f45 345 SUPERFAMILY SSF46785 266 330 2.21E-9 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS25160 fd79f8de7f1eaf5ac575b56a60e08f45 345 SMART SM00418 269 337 0.0049 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS25160 fd79f8de7f1eaf5ac575b56a60e08f45 345 Gene3D G3DSA:1.10.10.10 277 330 1.8E-9 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS25160 fd79f8de7f1eaf5ac575b56a60e08f45 345 Pfam PF12840 Helix-turn-helix domain 274 321 6.9E-8 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS21315 ec66cf85bad7d3b60a80327c860cf5a3 125 Gene3D G3DSA:3.10.180.10 11 123 9.8E-43 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS21315 ec66cf85bad7d3b60a80327c860cf5a3 125 SUPERFAMILY SSF54593 10 124 2.75E-21 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS21315 ec66cf85bad7d3b60a80327c860cf5a3 125 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 11 120 9.2E-5 T 09-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain TK78_RS16990 a48412c9edb8c845d571211d30c86751 446 TIGRFAM TIGR01413 Dyp_perox_fam: Dyp-type peroxidase family 88 434 5.3E-91 T 09-03-2017 IPR006314 Dyp-type peroxidase GO:0004601|GO:0020037|GO:0055114 TK78_RS16990 a48412c9edb8c845d571211d30c86751 446 SUPERFAMILY SSF54909 83 439 1.09E-81 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS16990 a48412c9edb8c845d571211d30c86751 446 Pfam PF04261 Dyp-type peroxidase family 88 434 2.8E-104 T 09-03-2017 IPR006314 Dyp-type peroxidase GO:0004601|GO:0020037|GO:0055114 TK78_RS16990 a48412c9edb8c845d571211d30c86751 446 TIGRFAM TIGR01412 tat_substr_1: Tat-translocated enzyme 29 445 7.4E-155 T 09-03-2017 IPR006313 Deferrochelatase/peroxidase EfeB GO:0004601|GO:0015684|GO:0020037|GO:0033212 TK78_RS24445 1f84433fa6e275ad5f7c76d7c757131b 339 Gene3D G3DSA:3.30.420.40 154 180 1.8E-36 T 09-03-2017 TK78_RS24445 1f84433fa6e275ad5f7c76d7c757131b 339 Gene3D G3DSA:3.30.420.40 257 311 1.8E-36 T 09-03-2017 TK78_RS24445 1f84433fa6e275ad5f7c76d7c757131b 339 Pfam PF06723 MreB/Mbl protein 6 330 6.9E-156 T 09-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 TK78_RS24445 1f84433fa6e275ad5f7c76d7c757131b 339 TIGRFAM TIGR00904 mreB: cell shape determining protein, MreB/Mrl family 6 330 4.0E-153 T 09-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 TK78_RS24445 1f84433fa6e275ad5f7c76d7c757131b 339 Gene3D G3DSA:3.90.640.10 181 253 6.4E-32 T 09-03-2017 TK78_RS24445 1f84433fa6e275ad5f7c76d7c757131b 339 Gene3D G3DSA:3.30.420.40 6 153 1.0E-48 T 09-03-2017 TK78_RS24445 1f84433fa6e275ad5f7c76d7c757131b 339 SUPERFAMILY SSF53067 144 322 1.73E-50 T 09-03-2017 TK78_RS24445 1f84433fa6e275ad5f7c76d7c757131b 339 SUPERFAMILY SSF53067 5 142 4.89E-43 T 09-03-2017 TK78_RS24445 1f84433fa6e275ad5f7c76d7c757131b 339 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 294 320 5.1E-62 T 09-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 TK78_RS24445 1f84433fa6e275ad5f7c76d7c757131b 339 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 181 201 5.1E-62 T 09-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 TK78_RS24445 1f84433fa6e275ad5f7c76d7c757131b 339 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 63 86 5.1E-62 T 09-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 TK78_RS24445 1f84433fa6e275ad5f7c76d7c757131b 339 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 126 145 5.1E-62 T 09-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 TK78_RS24445 1f84433fa6e275ad5f7c76d7c757131b 339 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 43 61 5.1E-62 T 09-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 TK78_RS21430 1080e1cfad77c63e72f4df93ce82eb13 668 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 335 441 9.3E-10 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS21430 1080e1cfad77c63e72f4df93ce82eb13 668 SMART SM00387 332 443 1.7E-8 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS21430 1080e1cfad77c63e72f4df93ce82eb13 668 Gene3D G3DSA:3.30.565.10 314 447 1.8E-15 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS21430 1080e1cfad77c63e72f4df93ce82eb13 668 SUPERFAMILY SSF55874 318 462 1.83E-16 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS27425 f05d7e6c5165780088ab0732de16ef1f 250 SUPERFAMILY SSF53300 48 198 3.71E-14 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS27425 f05d7e6c5165780088ab0732de16ef1f 250 Pfam PF10138 vWA found in TerF C terminus 47 249 2.1E-67 T 09-03-2017 IPR019303 vWA found in TerF C terminus TK78_RS27425 f05d7e6c5165780088ab0732de16ef1f 250 Gene3D G3DSA:3.40.50.410 50 185 6.9E-6 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS27425 f05d7e6c5165780088ab0732de16ef1f 250 SMART SM00327 47 221 4.8E-5 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS09105 7773108883e42b96f559f9e3986e4a45 399 ProSitePatterns PS00135 Serine proteases, trypsin family, serine active site. 341 352 - T 09-03-2017 IPR033116 Serine proteases, trypsin family, serine active site TK78_RS09105 7773108883e42b96f559f9e3986e4a45 399 SUPERFAMILY SSF50494 196 396 1.43E-24 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS09105 7773108883e42b96f559f9e3986e4a45 399 Pfam PF02983 Alpha-lytic protease prodomain 119 174 2.2E-11 T 09-03-2017 IPR004236 Peptidase S1A, alpha-lytic prodomain GO:0005576|GO:0006508|GO:0008236 TK78_RS09105 7773108883e42b96f559f9e3986e4a45 399 Gene3D G3DSA:2.40.10.10 282 384 7.8E-20 T 09-03-2017 TK78_RS09105 7773108883e42b96f559f9e3986e4a45 399 Gene3D G3DSA:3.30.300.50 118 188 1.7E-18 T 09-03-2017 TK78_RS09105 7773108883e42b96f559f9e3986e4a45 399 PIRSF PIRSF001134 1 399 6.1E-64 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS09105 7773108883e42b96f559f9e3986e4a45 399 Gene3D G3DSA:2.40.10.10 195 281 7.3E-12 T 09-03-2017 TK78_RS09105 7773108883e42b96f559f9e3986e4a45 399 ProSitePatterns PS00134 Serine proteases, trypsin family, histidine active site. 226 231 - T 09-03-2017 IPR018114 Serine proteases, trypsin family, histidine active site GO:0004252|GO:0006508 TK78_RS09105 7773108883e42b96f559f9e3986e4a45 399 Gene3D G3DSA:3.30.300.50 39 115 1.4E-6 T 09-03-2017 TK78_RS09105 7773108883e42b96f559f9e3986e4a45 399 Pfam PF00089 Trypsin 222 370 3.3E-5 T 09-03-2017 IPR001254 Serine proteases, trypsin domain GO:0004252|GO:0006508 TK78_RS09105 7773108883e42b96f559f9e3986e4a45 399 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 332 355 2.5E-15 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS09105 7773108883e42b96f559f9e3986e4a45 399 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 224 238 2.5E-15 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS09105 7773108883e42b96f559f9e3986e4a45 399 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 356 370 2.5E-15 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS09105 7773108883e42b96f559f9e3986e4a45 399 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 290 310 2.5E-15 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS32070 6bda96af8249fdc15be66ae70ead572f 237 SMART SM01007 11 202 5.2E-52 T 09-03-2017 IPR001303 Class II aldolase/adducin N-terminal TK78_RS32070 6bda96af8249fdc15be66ae70ead572f 237 Pfam PF00596 Class II Aldolase and Adducin N-terminal domain 12 202 3.9E-40 T 09-03-2017 IPR001303 Class II aldolase/adducin N-terminal TK78_RS32070 6bda96af8249fdc15be66ae70ead572f 237 SUPERFAMILY SSF53639 8 223 9.61E-57 T 09-03-2017 IPR001303 Class II aldolase/adducin N-terminal TK78_RS32070 6bda96af8249fdc15be66ae70ead572f 237 Gene3D G3DSA:3.40.225.10 8 232 1.0E-61 T 09-03-2017 IPR001303 Class II aldolase/adducin N-terminal TK78_RS32140 fb14d71ca13a674db70dac61cd65788b 328 SUPERFAMILY SSF53807 39 317 1.92E-37 T 09-03-2017 TK78_RS32140 fb14d71ca13a674db70dac61cd65788b 328 Gene3D G3DSA:3.40.50.1980 37 161 6.0E-24 T 09-03-2017 TK78_RS32140 fb14d71ca13a674db70dac61cd65788b 328 Gene3D G3DSA:3.40.50.1980 162 327 9.7E-15 T 09-03-2017 TK78_RS32140 fb14d71ca13a674db70dac61cd65788b 328 Pfam PF01497 Periplasmic binding protein 108 305 1.7E-15 T 09-03-2017 IPR002491 ABC transporter periplasmic binding domain GO:0005488 TK78_RS29295 102be66530cf02ddeebbe6c55dc899e7 236 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 87 199 3.7E-13 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS29295 102be66530cf02ddeebbe6c55dc899e7 236 SUPERFAMILY SSF56784 19 219 2.89E-43 T 09-03-2017 IPR023214 HAD-like domain TK78_RS29295 102be66530cf02ddeebbe6c55dc899e7 236 Gene3D G3DSA:3.40.50.1000 12 32 2.9E-39 T 09-03-2017 IPR023214 HAD-like domain TK78_RS29295 102be66530cf02ddeebbe6c55dc899e7 236 Gene3D G3DSA:3.40.50.1000 104 220 2.9E-39 T 09-03-2017 IPR023214 HAD-like domain TK78_RS29295 102be66530cf02ddeebbe6c55dc899e7 236 Pfam PF13419 Haloacid dehalogenase-like hydrolase 21 199 8.6E-23 T 09-03-2017 IPR023214 HAD-like domain TK78_RS07070 d926a2fd80ad781337842c64c7eaaa0a 553 SUPERFAMILY SSF56801 7 512 9.16E-103 T 09-03-2017 TK78_RS07070 d926a2fd80ad781337842c64c7eaaa0a 553 Gene3D G3DSA:3.40.50.980 8 170 1.9E-28 T 09-03-2017 TK78_RS07070 d926a2fd80ad781337842c64c7eaaa0a 553 ProSitePatterns PS00455 Putative AMP-binding domain signature. 165 176 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS07070 d926a2fd80ad781337842c64c7eaaa0a 553 Gene3D G3DSA:3.40.50.980 171 328 5.3E-32 T 09-03-2017 TK78_RS07070 d926a2fd80ad781337842c64c7eaaa0a 553 Gene3D G3DSA:3.30.300.30 413 509 5.8E-18 T 09-03-2017 TK78_RS07070 d926a2fd80ad781337842c64c7eaaa0a 553 Gene3D G3DSA:2.30.38.10 336 407 6.2E-13 T 09-03-2017 TK78_RS07070 d926a2fd80ad781337842c64c7eaaa0a 553 Pfam PF00501 AMP-binding enzyme 19 418 3.6E-63 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS30140 047fcb97978b0cca6813e50fb4560af1 183 Gene3D G3DSA:3.40.50.2020 9 182 7.9E-63 T 09-03-2017 IPR029057 Phosphoribosyltransferase-like TK78_RS30140 047fcb97978b0cca6813e50fb4560af1 183 Hamap MF_00004 Adenine phosphoribosyltransferase [apt]. 12 183 35.331 T 09-03-2017 IPR005764 Adenine phosphoribosyl transferase GO:0003999|GO:0005737|GO:0006168 KEGG: 00230+2.4.2.7|MetaCyc: PWY-6605|MetaCyc: PWY-6610|Reactome: R-HSA-74217 TK78_RS30140 047fcb97978b0cca6813e50fb4560af1 183 TIGRFAM TIGR01090 apt: adenine phosphoribosyltransferase 13 170 1.0E-58 T 09-03-2017 IPR005764 Adenine phosphoribosyl transferase GO:0003999|GO:0005737|GO:0006168 KEGG: 00230+2.4.2.7|MetaCyc: PWY-6605|MetaCyc: PWY-6610|Reactome: R-HSA-74217 TK78_RS30140 047fcb97978b0cca6813e50fb4560af1 183 SUPERFAMILY SSF53271 14 169 1.04E-46 T 09-03-2017 IPR029057 Phosphoribosyltransferase-like TK78_RS30140 047fcb97978b0cca6813e50fb4560af1 183 Pfam PF00156 Phosphoribosyl transferase domain 56 158 2.6E-14 T 09-03-2017 IPR000836 Phosphoribosyltransferase domain GO:0009116 TK78_RS31745 64219cf428d1531404c67f80f07838be 453 Gene3D G3DSA:3.50.50.60 4 101 3.2E-15 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS31745 64219cf428d1531404c67f80f07838be 453 Gene3D G3DSA:3.50.50.60 176 338 1.5E-25 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS31745 64219cf428d1531404c67f80f07838be 453 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 5 27 2.1E-6 T 09-03-2017 TK78_RS31745 64219cf428d1531404c67f80f07838be 453 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 164 189 2.1E-6 T 09-03-2017 TK78_RS31745 64219cf428d1531404c67f80f07838be 453 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 299 306 2.1E-6 T 09-03-2017 TK78_RS31745 64219cf428d1531404c67f80f07838be 453 Gene3D G3DSA:3.50.50.60 102 175 1.1E-4 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS31745 64219cf428d1531404c67f80f07838be 453 SUPERFAMILY SSF51905 3 338 9.97E-25 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS31745 64219cf428d1531404c67f80f07838be 453 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 5 330 4.5E-43 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS31745 64219cf428d1531404c67f80f07838be 453 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 164 182 1.2E-11 T 09-03-2017 TK78_RS31745 64219cf428d1531404c67f80f07838be 453 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 6 25 1.2E-11 T 09-03-2017 TK78_RS31745 64219cf428d1531404c67f80f07838be 453 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 284 306 1.2E-11 T 09-03-2017 TK78_RS31745 64219cf428d1531404c67f80f07838be 453 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 104 122 1.2E-11 T 09-03-2017 TK78_RS10465 1e1215b924d2bfa3f7e2fa5dc3fdc636 192 SUPERFAMILY SSF46689 4 71 1.3E-12 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS10465 1e1215b924d2bfa3f7e2fa5dc3fdc636 192 Pfam PF00440 Bacterial regulatory proteins, tetR family 8 54 2.3E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS10465 1e1215b924d2bfa3f7e2fa5dc3fdc636 192 Gene3D G3DSA:1.10.357.10 4 184 1.7E-19 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS00450 784863cfef7d6ce7d62af231258a51eb 313 SUPERFAMILY SSF88946 8 88 3.34E-15 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS00450 784863cfef7d6ce7d62af231258a51eb 313 Gene3D G3DSA:1.10.1740.10 7 74 1.1E-15 T 09-03-2017 TK78_RS00450 784863cfef7d6ce7d62af231258a51eb 313 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 14 161 2.0E-16 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS00450 784863cfef7d6ce7d62af231258a51eb 313 Gene3D G3DSA:1.10.10.10 107 162 1.2E-13 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS00450 784863cfef7d6ce7d62af231258a51eb 313 Gene3D G3DSA:3.10.450.50 171 293 5.8E-10 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS00450 784863cfef7d6ce7d62af231258a51eb 313 SUPERFAMILY SSF54427 173 287 8.33E-11 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS00450 784863cfef7d6ce7d62af231258a51eb 313 SUPERFAMILY SSF88659 106 162 1.81E-11 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS00450 784863cfef7d6ce7d62af231258a51eb 313 Pfam PF04542 Sigma-70 region 2 10 72 5.0E-17 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS00450 784863cfef7d6ce7d62af231258a51eb 313 Pfam PF08281 Sigma-70, region 4 108 160 5.8E-14 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS11380 9fa1840158db17e2afc5eaff615b5b76 343 SUPERFAMILY SSF56655 17 329 9.71E-111 T 09-03-2017 TK78_RS11380 9fa1840158db17e2afc5eaff615b5b76 343 Gene3D G3DSA:3.30.540.10 190 338 1.1E-44 T 09-03-2017 TK78_RS11380 9fa1840158db17e2afc5eaff615b5b76 343 Gene3D G3DSA:3.30.540.10 17 189 3.6E-65 T 09-03-2017 TK78_RS11380 9fa1840158db17e2afc5eaff615b5b76 343 TIGRFAM TIGR00330 glpX: fructose-1,6-bisphosphatase, class II 19 330 1.2E-114 T 09-03-2017 IPR004464 Fructose-1,6-bisphosphatase class 2/Sedoheputulose-1,7-bisphosphatase GO:0006071|GO:0006094|GO:0042132 KEGG: 00010+3.1.3.11|KEGG: 00030+3.1.3.11|KEGG: 00051+3.1.3.11|KEGG: 00680+3.1.3.11|KEGG: 00710+3.1.3.11|MetaCyc: PWY-5484 TK78_RS11380 9fa1840158db17e2afc5eaff615b5b76 343 PIRSF PIRSF004532 17 337 1.6E-144 T 09-03-2017 IPR004464 Fructose-1,6-bisphosphatase class 2/Sedoheputulose-1,7-bisphosphatase GO:0006071|GO:0006094|GO:0042132 KEGG: 00010+3.1.3.11|KEGG: 00030+3.1.3.11|KEGG: 00051+3.1.3.11|KEGG: 00680+3.1.3.11|KEGG: 00710+3.1.3.11|MetaCyc: PWY-5484 TK78_RS11380 9fa1840158db17e2afc5eaff615b5b76 343 Pfam PF03320 Bacterial fructose-1,6-bisphosphatase, glpX-encoded 19 326 1.5E-140 T 09-03-2017 IPR004464 Fructose-1,6-bisphosphatase class 2/Sedoheputulose-1,7-bisphosphatase GO:0006071|GO:0006094|GO:0042132 KEGG: 00010+3.1.3.11|KEGG: 00030+3.1.3.11|KEGG: 00051+3.1.3.11|KEGG: 00680+3.1.3.11|KEGG: 00710+3.1.3.11|MetaCyc: PWY-5484 TK78_RS30995 049d4a62ec19b818afa5e8f4d25e6cce 536 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 321 339 1.4E-31 T 09-03-2017 TK78_RS30995 049d4a62ec19b818afa5e8f4d25e6cce 536 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 165 180 1.4E-31 T 09-03-2017 TK78_RS30995 049d4a62ec19b818afa5e8f4d25e6cce 536 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 15 37 1.4E-31 T 09-03-2017 TK78_RS30995 049d4a62ec19b818afa5e8f4d25e6cce 536 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 303 319 1.4E-31 T 09-03-2017 TK78_RS30995 049d4a62ec19b818afa5e8f4d25e6cce 536 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 288 303 1.4E-31 T 09-03-2017 TK78_RS30995 049d4a62ec19b818afa5e8f4d25e6cce 536 Gene3D G3DSA:3.50.50.60 276 360 3.6E-44 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS30995 049d4a62ec19b818afa5e8f4d25e6cce 536 Gene3D G3DSA:3.50.50.60 14 191 3.6E-44 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS30995 049d4a62ec19b818afa5e8f4d25e6cce 536 Pfam PF01494 FAD binding domain 14 352 1.7E-58 T 09-03-2017 IPR002938 FAD-binding domain GO:0071949 TK78_RS30995 049d4a62ec19b818afa5e8f4d25e6cce 536 SUPERFAMILY SSF51905 275 377 9.66E-61 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS30995 049d4a62ec19b818afa5e8f4d25e6cce 536 SUPERFAMILY SSF51905 15 186 9.66E-61 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS24220 8f61fb77c8d466b4da7e8d91674c9289 342 SUPERFAMILY SSF55347 126 324 1.24E-60 T 09-03-2017 TK78_RS24220 8f61fb77c8d466b4da7e8d91674c9289 342 Pfam PF02774 Semialdehyde dehydrogenase, dimerisation domain 136 323 1.5E-54 T 09-03-2017 IPR012280 Semialdehyde dehydrogenase, dimerisation domain GO:0003942|GO:0005737|GO:0008652|GO:0016620|GO:0046983|GO:0055114 KEGG: 00220+1.2.1.38|MetaCyc: PWY-5154|MetaCyc: PWY-7400 TK78_RS24220 8f61fb77c8d466b4da7e8d91674c9289 342 PIRSF PIRSF000148 1 341 4.1E-109 T 09-03-2017 IPR012080 Aspartate-semialdehyde dehydrogenase GO:0004073|GO:0009086|GO:0009088|GO:0009089|GO:0009097|GO:0050661|GO:0055114 KEGG: 00260+1.2.1.11|KEGG: 00261+1.2.1.11|KEGG: 00270+1.2.1.11|KEGG: 00300+1.2.1.11|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153 TK78_RS24220 8f61fb77c8d466b4da7e8d91674c9289 342 TIGRFAM TIGR01296 asd_B: aspartate-semialdehyde dehydrogenase 2 337 5.9E-130 T 09-03-2017 IPR005986 Aspartate-semialdehyde dehydrogenase, beta-type GO:0004073|GO:0009086|GO:0009088|GO:0009089|GO:0009097|GO:0050661|GO:0055114 KEGG: 00260+1.2.1.11|KEGG: 00261+1.2.1.11|KEGG: 00270+1.2.1.11|KEGG: 00300+1.2.1.11|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153 TK78_RS24220 8f61fb77c8d466b4da7e8d91674c9289 342 SUPERFAMILY SSF51735 2 153 2.81E-46 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS24220 8f61fb77c8d466b4da7e8d91674c9289 342 Hamap MF_02121 Aspartate-semialdehyde dehydrogenase [asd]. 1 337 33.695 T 09-03-2017 IPR012080 Aspartate-semialdehyde dehydrogenase GO:0004073|GO:0009086|GO:0009088|GO:0009089|GO:0009097|GO:0050661|GO:0055114 KEGG: 00260+1.2.1.11|KEGG: 00261+1.2.1.11|KEGG: 00270+1.2.1.11|KEGG: 00300+1.2.1.11|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153 TK78_RS24220 8f61fb77c8d466b4da7e8d91674c9289 342 ProSitePatterns PS01103 Aspartate-semialdehyde dehydrogenase signature. 240 254 - T 09-03-2017 IPR000319 Aspartate-semialdehyde dehydrogenase, conserved site GO:0004073|GO:0006520|GO:0050661|GO:0055114 KEGG: 00260+1.2.1.11|KEGG: 00261+1.2.1.11|KEGG: 00270+1.2.1.11|KEGG: 00300+1.2.1.11|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153 TK78_RS24220 8f61fb77c8d466b4da7e8d91674c9289 342 SMART SM00859 2 117 1.2E-39 T 09-03-2017 IPR000534 Semialdehyde dehydrogenase, NAD-binding GO:0016620|GO:0051287|GO:0055114 TK78_RS24220 8f61fb77c8d466b4da7e8d91674c9289 342 Gene3D G3DSA:3.30.360.10 139 319 3.1E-68 T 09-03-2017 TK78_RS24220 8f61fb77c8d466b4da7e8d91674c9289 342 Pfam PF01118 Semialdehyde dehydrogenase, NAD binding domain 2 114 3.9E-31 T 09-03-2017 IPR000534 Semialdehyde dehydrogenase, NAD-binding GO:0016620|GO:0051287|GO:0055114 TK78_RS24220 8f61fb77c8d466b4da7e8d91674c9289 342 Gene3D G3DSA:3.40.50.720 1 138 3.9E-60 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS11825 cca57b4c9e5545d33452c7b633d205da 293 SUPERFAMILY SSF102588 4 291 8.5E-70 T 09-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 TK78_RS11825 cca57b4c9e5545d33452c7b633d205da 293 TIGRFAM TIGR03446 mycothiol_Mca: mycothiol conjugate amidase Mca 5 289 2.2E-145 T 09-03-2017 IPR017811 Mycothiol S-conjugate amidase Mca GO:0010126 KEGG: 00311+3.5.1.11 TK78_RS11825 cca57b4c9e5545d33452c7b633d205da 293 Gene3D G3DSA:3.40.50.10320 3 291 1.6E-82 T 09-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 TK78_RS11825 cca57b4c9e5545d33452c7b633d205da 293 Pfam PF02585 GlcNAc-PI de-N-acetylase 8 152 2.5E-24 T 09-03-2017 IPR003737 N-acetylglucosaminyl phosphatidylinositol deacetylase-related Reactome: R-HSA-162710 TK78_RS11825 cca57b4c9e5545d33452c7b633d205da 293 Hamap MF_01482 Mycothiol S-conjugate amidase [mca]. 8 290 51.102 T 09-03-2017 IPR017811 Mycothiol S-conjugate amidase Mca GO:0010126 KEGG: 00311+3.5.1.11 TK78_RS13695 ded4045507212dc0064011217554aa76 427 Gene3D G3DSA:3.50.50.60 8 175 5.4E-23 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS13695 ded4045507212dc0064011217554aa76 427 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 161 176 1.1E-10 T 09-03-2017 TK78_RS13695 ded4045507212dc0064011217554aa76 427 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 298 313 1.1E-10 T 09-03-2017 TK78_RS13695 ded4045507212dc0064011217554aa76 427 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 11 33 1.1E-10 T 09-03-2017 TK78_RS13695 ded4045507212dc0064011217554aa76 427 Gene3D G3DSA:3.30.9.10 176 343 1.4E-52 T 09-03-2017 TK78_RS13695 ded4045507212dc0064011217554aa76 427 Pfam PF01494 FAD binding domain 10 187 7.4E-13 T 09-03-2017 IPR002938 FAD-binding domain GO:0071949 TK78_RS13695 ded4045507212dc0064011217554aa76 427 TIGRFAM TIGR02032 GG-red-SF: geranylgeranyl reductase family 11 333 1.5E-89 T 09-03-2017 IPR011777 Geranylgeranyl reductase family GO:0016628|GO:0055114 TK78_RS13695 ded4045507212dc0064011217554aa76 427 SUPERFAMILY SSF51905 288 380 1.78E-45 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS13695 ded4045507212dc0064011217554aa76 427 SUPERFAMILY SSF51905 8 192 1.78E-45 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS15260 9302dc5f376e4a8e64d9ffecf82cda42 617 Pfam PF07730 Histidine kinase 182 246 2.4E-11 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS15260 9302dc5f376e4a8e64d9ffecf82cda42 617 SUPERFAMILY SSF55874 306 424 1.04E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS05275 fcedea5c8d5fde04b600d43dbf01d802 296 Gene3D G3DSA:3.30.43.10 2 53 6.0E-15 T 09-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 TK78_RS05275 fcedea5c8d5fde04b600d43dbf01d802 296 SUPERFAMILY SSF56176 2 164 1.47E-48 T 09-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 TK78_RS05275 fcedea5c8d5fde04b600d43dbf01d802 296 SUPERFAMILY SSF55447 171 284 9.94E-19 T 09-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal TK78_RS05275 fcedea5c8d5fde04b600d43dbf01d802 296 Gene3D G3DSA:3.30.390.50 172 283 1.5E-31 T 09-03-2017 TK78_RS05275 fcedea5c8d5fde04b600d43dbf01d802 296 Gene3D G3DSA:3.30.465.10 54 164 1.4E-33 T 09-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 TK78_RS05275 fcedea5c8d5fde04b600d43dbf01d802 296 Pfam PF00941 FAD binding domain in molybdopterin dehydrogenase 2 164 3.9E-46 T 09-03-2017 IPR002346 Molybdopterin dehydrogenase, FAD-binding GO:0016491|GO:0055114 TK78_RS05275 fcedea5c8d5fde04b600d43dbf01d802 296 Pfam PF03450 CO dehydrogenase flavoprotein C-terminal domain 172 278 1.6E-10 T 09-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal TK78_RS05275 fcedea5c8d5fde04b600d43dbf01d802 296 SMART SM01092 171 281 2.0E-18 T 09-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal TK78_RS14115 e2bf31184fff9c1d5bccc82c26388d74 213 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 35 114 1.3E-25 T 09-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS14115 e2bf31184fff9c1d5bccc82c26388d74 213 Pfam PF10590 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region 168 213 2.2E-20 T 09-03-2017 IPR019576 Pyridoxine 5'-phosphate oxidase, dimerisation, C-terminal GO:0016638|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS14115 e2bf31184fff9c1d5bccc82c26388d74 213 SUPERFAMILY SSF50475 12 213 2.32E-66 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS14115 e2bf31184fff9c1d5bccc82c26388d74 213 Gene3D G3DSA:2.30.110.10 12 213 6.6E-85 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS14115 e2bf31184fff9c1d5bccc82c26388d74 213 PIRSF PIRSF000190 1 213 6.8E-82 T 09-03-2017 IPR000659 Pyridoxamine 5'-phosphate oxidase GO:0004733|GO:0008615|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS14115 e2bf31184fff9c1d5bccc82c26388d74 213 Hamap MF_01629 Pyridoxine/pyridoxamine 5'-phosphate oxidase [pdxH]. 4 213 39.787 T 09-03-2017 IPR000659 Pyridoxamine 5'-phosphate oxidase GO:0004733|GO:0008615|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS14115 e2bf31184fff9c1d5bccc82c26388d74 213 ProSitePatterns PS01064 Pyridoxamine 5'-phosphate oxidase signature. 178 191 - T 09-03-2017 IPR019740 Pyridoxamine 5'-phosphate oxidase, conserved site GO:0016638|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS14115 e2bf31184fff9c1d5bccc82c26388d74 213 TIGRFAM TIGR00558 pdxH: pyridoxamine 5'-phosphate oxidase 2 213 1.5E-80 T 09-03-2017 IPR000659 Pyridoxamine 5'-phosphate oxidase GO:0004733|GO:0008615|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS28040 08c92defc171f2d804594cc2e09e86b4 414 Gene3D G3DSA:1.20.1250.20 208 389 2.3E-16 T 09-03-2017 TK78_RS28040 08c92defc171f2d804594cc2e09e86b4 414 Gene3D G3DSA:1.20.1250.20 9 188 6.8E-20 T 09-03-2017 TK78_RS28040 08c92defc171f2d804594cc2e09e86b4 414 Pfam PF07690 Major Facilitator Superfamily 14 342 1.4E-31 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS28040 08c92defc171f2d804594cc2e09e86b4 414 SUPERFAMILY SSF103473 8 387 6.41E-42 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS12585 6d8336ad46de82450bf93d2d52d9ae42 395 Pfam PF00877 NlpC/P60 family 295 380 1.0E-23 T 09-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain TK78_RS12585 6d8336ad46de82450bf93d2d52d9ae42 395 Gene3D G3DSA:3.90.1720.10 281 384 1.4E-43 T 09-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain TK78_RS12585 6d8336ad46de82450bf93d2d52d9ae42 395 SUPERFAMILY SSF54001 281 393 2.35E-41 T 09-03-2017 TK78_RS25770 a42283e944224a53340ac524f10ae452 720 Pfam PF14378 PAP2 superfamily 476 657 5.6E-48 T 09-03-2017 IPR026841 Inositolphosphotransferase Aur1/Ipt1 TK78_RS25770 a42283e944224a53340ac524f10ae452 720 Pfam PF09594 Protein of unknown function (DUF2029) 94 329 5.7E-31 T 09-03-2017 IPR018584 Glycosyltransferase family 87 GO:0016758 TK78_RS11575 782ff1b63ff7db8caeac2b32ce82de6b 267 Gene3D G3DSA:3.40.50.1000 127 262 6.3E-29 T 09-03-2017 IPR023214 HAD-like domain TK78_RS11575 782ff1b63ff7db8caeac2b32ce82de6b 267 TIGRFAM TIGR01428 HAD_type_II: haloacid dehalogenase, type II 60 241 8.4E-41 T 09-03-2017 IPR006328 Haloacid dehalogenase, type II GO:0008152|GO:0019120 KEGG: 00361+3.8.1.2|KEGG: 00625+3.8.1.2|MetaCyc: PWY-7425 TK78_RS11575 782ff1b63ff7db8caeac2b32ce82de6b 267 SUPERFAMILY SSF56784 6 264 1.8E-34 T 09-03-2017 IPR023214 HAD-like domain TK78_RS11575 782ff1b63ff7db8caeac2b32ce82de6b 267 Pfam PF13242 HAD-hyrolase-like 193 260 2.1E-6 T 09-03-2017 TK78_RS11575 782ff1b63ff7db8caeac2b32ce82de6b 267 TIGRFAM TIGR01493 HAD-SF-IA-v2: HAD hydrolase, family IA, variant 2 129 227 1.4E-27 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS24745 c88e24b30cf66b6ec0d22e145ecdff52 413 Pfam PF04055 Radical SAM superfamily 38 216 3.3E-23 T 09-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 TK78_RS24745 c88e24b30cf66b6ec0d22e145ecdff52 413 SMART SM00729 32 262 2.7E-62 T 09-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 TK78_RS24745 c88e24b30cf66b6ec0d22e145ecdff52 413 Gene3D G3DSA:3.80.30.20 35 277 1.4E-37 T 09-03-2017 IPR023404 Radical SAM, alpha/beta horseshoe TK78_RS24745 c88e24b30cf66b6ec0d22e145ecdff52 413 SUPERFAMILY SSF102114 22 411 8.63E-109 T 09-03-2017 TK78_RS24745 c88e24b30cf66b6ec0d22e145ecdff52 413 TIGRFAM TIGR00539 hemN_rel: putative oxygen-independent coproporphyrinogen III oxidase 35 367 2.4E-72 T 09-03-2017 IPR004559 Coproporphyrinogen III oxidase, oxygen-independent related GO:0004109|GO:0005737|GO:0006779|GO:0055114 TK78_RS05485 87b6a2beecba1f0d84faa6a5362ec44a 181 SUPERFAMILY SSF52540 7 178 4.18E-33 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS05485 87b6a2beecba1f0d84faa6a5362ec44a 181 Pfam PF01583 Adenylylsulphate kinase 7 163 2.9E-58 T 09-03-2017 TK78_RS05485 87b6a2beecba1f0d84faa6a5362ec44a 181 TIGRFAM TIGR00455 apsK: adenylyl-sulfate kinase 6 173 6.1E-58 T 09-03-2017 IPR002891 Adenylyl-sulfate kinase GO:0000103|GO:0004020|GO:0005524 KEGG: 00230+2.7.1.25|KEGG: 00920+2.7.1.25|MetaCyc: PWY-5340|Reactome: R-HSA-174362|Reactome: R-HSA-2408550 TK78_RS05485 87b6a2beecba1f0d84faa6a5362ec44a 181 Gene3D G3DSA:3.40.50.300 7 180 6.7E-64 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS05485 87b6a2beecba1f0d84faa6a5362ec44a 181 Hamap MF_00065 Adenylyl-sulfate kinase [cysC]. 5 179 33.41 T 09-03-2017 IPR002891 Adenylyl-sulfate kinase GO:0000103|GO:0004020|GO:0005524 KEGG: 00230+2.7.1.25|KEGG: 00920+2.7.1.25|MetaCyc: PWY-5340|Reactome: R-HSA-174362|Reactome: R-HSA-2408550 TK78_RS26845 8743343fdd9dbe0f2363f79de183841e 416 PIRSF PIRSF010361 1 412 5.1E-77 T 09-03-2017 IPR016570 Uncharacterised conserved protein UCP010361, membrane TK78_RS26845 8743343fdd9dbe0f2363f79de183841e 416 Pfam PF09594 Protein of unknown function (DUF2029) 67 314 1.6E-16 T 09-03-2017 IPR018584 Glycosyltransferase family 87 GO:0016758 TK78_RS01830 70723b23b0d5ac1cf55b7e3d29500ba1 341 Gene3D G3DSA:3.40.50.2300 176 309 3.4E-46 T 09-03-2017 TK78_RS01830 70723b23b0d5ac1cf55b7e3d29500ba1 341 SUPERFAMILY SSF53822 64 337 3.34E-70 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS01830 70723b23b0d5ac1cf55b7e3d29500ba1 341 SMART SM00354 4 74 4.4E-22 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS01830 70723b23b0d5ac1cf55b7e3d29500ba1 341 Gene3D G3DSA:1.10.260.40 6 56 9.4E-22 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS01830 70723b23b0d5ac1cf55b7e3d29500ba1 341 Pfam PF13377 Periplasmic binding protein-like domain 171 337 4.4E-36 T 09-03-2017 TK78_RS01830 70723b23b0d5ac1cf55b7e3d29500ba1 341 Pfam PF00356 Bacterial regulatory proteins, lacI family 7 50 2.7E-15 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS01830 70723b23b0d5ac1cf55b7e3d29500ba1 341 Gene3D G3DSA:3.40.50.2300 57 175 8.7E-44 T 09-03-2017 TK78_RS01830 70723b23b0d5ac1cf55b7e3d29500ba1 341 ProSitePatterns PS00356 LacI-type HTH domain signature. 7 25 - T 09-03-2017 TK78_RS01830 70723b23b0d5ac1cf55b7e3d29500ba1 341 SUPERFAMILY SSF47413 5 62 1.5E-15 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS31120 97db291ca9aaddbdf7e9f9854b27c0fa 278 Gene3D G3DSA:3.40.50.720 116 247 1.2E-32 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31120 97db291ca9aaddbdf7e9f9854b27c0fa 278 Pfam PF08501 Shikimate dehydrogenase substrate binding domain 13 95 9.5E-15 T 09-03-2017 IPR013708 Shikimate dehydrogenase substrate binding, N-terminal GO:0004764|GO:0055114 KEGG: 00400+1.1.1.25|MetaCyc: PWY-6163 TK78_RS31120 97db291ca9aaddbdf7e9f9854b27c0fa 278 SUPERFAMILY SSF53223 4 108 5.58E-23 T 09-03-2017 TK78_RS31120 97db291ca9aaddbdf7e9f9854b27c0fa 278 Gene3D G3DSA:3.40.192.10 5 115 2.2E-26 T 09-03-2017 TK78_RS31120 97db291ca9aaddbdf7e9f9854b27c0fa 278 Pfam PF00899 ThiF family 129 164 3.0E-5 T 09-03-2017 IPR000594 THIF-type NAD/FAD binding fold GO:0008641 TK78_RS31120 97db291ca9aaddbdf7e9f9854b27c0fa 278 SUPERFAMILY SSF51735 110 254 1.2E-27 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS24310 17ed4be4cccec7b6de74089b8ba74719 213 ProSitePatterns PS00088 Manganese and iron superoxide dismutases signature. 165 172 - T 09-03-2017 IPR019833 Manganese/iron superoxide dismutase, binding site GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 TK78_RS24310 17ed4be4cccec7b6de74089b8ba74719 213 Gene3D G3DSA:1.10.287.990 23 84 2.6E-21 T 09-03-2017 TK78_RS24310 17ed4be4cccec7b6de74089b8ba74719 213 Pfam PF00081 Iron/manganese superoxide dismutases, alpha-hairpin domain 3 83 7.5E-30 T 09-03-2017 IPR019831 Manganese/iron superoxide dismutase, N-terminal GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 TK78_RS24310 17ed4be4cccec7b6de74089b8ba74719 213 PRINTS PR01703 Manganese superoxide dismutase signature 125 133 1.1E-19 T 09-03-2017 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 TK78_RS24310 17ed4be4cccec7b6de74089b8ba74719 213 PRINTS PR01703 Manganese superoxide dismutase signature 163 175 1.1E-19 T 09-03-2017 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 TK78_RS24310 17ed4be4cccec7b6de74089b8ba74719 213 PRINTS PR01703 Manganese superoxide dismutase signature 28 41 1.1E-19 T 09-03-2017 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 TK78_RS24310 17ed4be4cccec7b6de74089b8ba74719 213 PRINTS PR01703 Manganese superoxide dismutase signature 67 80 1.1E-19 T 09-03-2017 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 TK78_RS24310 17ed4be4cccec7b6de74089b8ba74719 213 PRINTS PR01703 Manganese superoxide dismutase signature 7 18 1.1E-19 T 09-03-2017 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 TK78_RS24310 17ed4be4cccec7b6de74089b8ba74719 213 SUPERFAMILY SSF46609 2 89 2.36E-30 T 09-03-2017 IPR019831 Manganese/iron superoxide dismutase, N-terminal GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 TK78_RS24310 17ed4be4cccec7b6de74089b8ba74719 213 SUPERFAMILY SSF54719 98 204 9.3E-37 T 09-03-2017 IPR019832 Manganese/iron superoxide dismutase, C-terminal GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 TK78_RS24310 17ed4be4cccec7b6de74089b8ba74719 213 PIRSF PIRSF000349 1 207 2.2E-69 T 09-03-2017 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 TK78_RS24310 17ed4be4cccec7b6de74089b8ba74719 213 Pfam PF02777 Iron/manganese superoxide dismutases, C-terminal domain 98 198 2.0E-31 T 09-03-2017 IPR019832 Manganese/iron superoxide dismutase, C-terminal GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 TK78_RS01140 a320179dca7900be21c744c1c4986721 296 ProSitePatterns PS00135 Serine proteases, trypsin family, serine active site. 246 257 - T 09-03-2017 IPR033116 Serine proteases, trypsin family, serine active site TK78_RS01140 a320179dca7900be21c744c1c4986721 296 PIRSF PIRSF001134 10 296 1.1E-94 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS01140 a320179dca7900be21c744c1c4986721 296 Gene3D G3DSA:3.30.300.50 48 109 2.3E-8 T 09-03-2017 TK78_RS01140 a320179dca7900be21c744c1c4986721 296 Gene3D G3DSA:2.40.10.10 115 193 4.1E-24 T 09-03-2017 TK78_RS01140 a320179dca7900be21c744c1c4986721 296 Gene3D G3DSA:2.40.10.10 194 283 1.5E-29 T 09-03-2017 TK78_RS01140 a320179dca7900be21c744c1c4986721 296 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 237 260 3.6E-47 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS01140 a320179dca7900be21c744c1c4986721 296 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 261 275 3.6E-47 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS01140 a320179dca7900be21c744c1c4986721 296 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 196 216 3.6E-47 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS01140 a320179dca7900be21c744c1c4986721 296 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 217 234 3.6E-47 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS01140 a320179dca7900be21c744c1c4986721 296 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 142 156 3.6E-47 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS01140 a320179dca7900be21c744c1c4986721 296 Pfam PF02983 Alpha-lytic protease prodomain 44 98 2.1E-12 T 09-03-2017 IPR004236 Peptidase S1A, alpha-lytic prodomain GO:0005576|GO:0006508|GO:0008236 TK78_RS01140 a320179dca7900be21c744c1c4986721 296 SUPERFAMILY SSF50494 122 290 2.79E-36 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS01140 a320179dca7900be21c744c1c4986721 296 Pfam PF00089 Trypsin 173 288 3.5E-6 T 09-03-2017 IPR001254 Serine proteases, trypsin domain GO:0004252|GO:0006508 TK78_RS25040 8fe49cc756bf8a5bb8348c822589d048 190 SUPERFAMILY SSF52540 5 147 1.59E-15 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS25040 8fe49cc756bf8a5bb8348c822589d048 190 Pfam PF13671 AAA domain 5 137 5.9E-19 T 09-03-2017 TK78_RS25040 8fe49cc756bf8a5bb8348c822589d048 190 Gene3D G3DSA:3.40.50.300 5 145 1.5E-17 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07780 40adba219b66d64a091afea50a11440b 211 SMART SM00418 24 113 9.3E-9 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS07780 40adba219b66d64a091afea50a11440b 211 Pfam PF12840 Helix-turn-helix domain 26 82 1.1E-13 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS07780 40adba219b66d64a091afea50a11440b 211 Gene3D G3DSA:1.10.10.10 23 88 9.8E-15 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS07780 40adba219b66d64a091afea50a11440b 211 SUPERFAMILY SSF46785 23 107 4.49E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS23830 3c495cff1198f685deced05a82a60fe6 292 Gene3D G3DSA:3.20.20.80 80 290 4.0E-78 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS23830 3c495cff1198f685deced05a82a60fe6 292 SUPERFAMILY SSF51445 77 290 6.46E-72 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS23830 3c495cff1198f685deced05a82a60fe6 292 Pfam PF01183 Glycosyl hydrolases family 25 83 268 1.6E-51 T 09-03-2017 IPR002053 Glycoside hydrolase, family 25 GO:0003796|GO:0009253|GO:0016998 TK78_RS23830 3c495cff1198f685deced05a82a60fe6 292 SMART SM00641 80 189 1.1E-44 T 09-03-2017 IPR018077 Glycoside hydrolase, family 25 subgroup TK78_RS23830 3c495cff1198f685deced05a82a60fe6 292 ProSitePatterns PS00953 Glycosyl hydrolases family 25 active sites signature. 84 117 - T 09-03-2017 IPR008270 Glycoside hydrolase, family 25, active site GO:0003796|GO:0009253|GO:0016998 TK78_RS02135 9d24da63bd13b0ebc277dc41f32af77a 438 TIGRFAM TIGR03444 EgtA_Cys_ligase: ergothioneine biosynthesis glutamate--cysteine ligase EgtA 27 417 1.7E-130 T 09-03-2017 IPR017809 Glutamate--cysteine ligase EgtA, Actinobacteria GO:0004357|GO:0052699 KEGG: 00270+6.3.2.2|KEGG: 00480+6.3.2.2|MetaCyc: PWY-6840|MetaCyc: PWY-7255 TK78_RS02135 9d24da63bd13b0ebc277dc41f32af77a 438 Pfam PF04107 Glutamate-cysteine ligase family 2(GCS2) 40 344 1.2E-70 T 09-03-2017 IPR006336 Glutamate--cysteine ligase, GCS2 GO:0004357|GO:0042398 KEGG: 00270+6.3.2.2|KEGG: 00480+6.3.2.2|MetaCyc: PWY-6840|MetaCyc: PWY-7255 TK78_RS02135 9d24da63bd13b0ebc277dc41f32af77a 438 PIRSF PIRSF017901 14 426 4.4E-107 T 09-03-2017 TK78_RS02135 9d24da63bd13b0ebc277dc41f32af77a 438 SUPERFAMILY SSF55931 32 257 4.71E-35 T 09-03-2017 TK78_RS02135 9d24da63bd13b0ebc277dc41f32af77a 438 SUPERFAMILY SSF55931 293 415 4.71E-35 T 09-03-2017 TK78_RS02135 9d24da63bd13b0ebc277dc41f32af77a 438 Hamap MF_02034 Glutamate--cysteine ligase EgtA [egtA]. 15 415 30.95 T 09-03-2017 IPR017809 Glutamate--cysteine ligase EgtA, Actinobacteria GO:0004357|GO:0052699 KEGG: 00270+6.3.2.2|KEGG: 00480+6.3.2.2|MetaCyc: PWY-6840|MetaCyc: PWY-7255 TK78_RS34575 57da71843f936301f2615bef66ec38c8 1000 Gene3D G3DSA:2.120.10.30 489 532 3.7E-9 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS34575 57da71843f936301f2615bef66ec38c8 1000 Gene3D G3DSA:2.120.10.30 239 418 3.7E-9 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS34575 57da71843f936301f2615bef66ec38c8 1000 Gene3D G3DSA:3.90.182.10 93 213 1.3E-23 T 09-03-2017 IPR011658 PA14 domain TK78_RS34575 57da71843f936301f2615bef66ec38c8 1000 SUPERFAMILY SSF101898 489 535 1.65E-13 T 09-03-2017 TK78_RS34575 57da71843f936301f2615bef66ec38c8 1000 SUPERFAMILY SSF101898 234 418 1.65E-13 T 09-03-2017 TK78_RS34575 57da71843f936301f2615bef66ec38c8 1000 Pfam PF07691 PA14 domain 47 183 9.2E-19 T 09-03-2017 IPR011658 PA14 domain TK78_RS34575 57da71843f936301f2615bef66ec38c8 1000 Pfam PF06439 Domain of Unknown Function (DUF1080) 812 997 1.4E-36 T 09-03-2017 IPR010496 Domain of unknown function DUF1080 TK78_RS34575 57da71843f936301f2615bef66ec38c8 1000 SUPERFAMILY SSF49785 673 805 3.54E-23 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS34575 57da71843f936301f2615bef66ec38c8 1000 Pfam PF16990 Carbohydrate binding module (family 35) 677 806 7.1E-15 T 09-03-2017 IPR005084 Carbohydrate binding module family 6 GO:0030246 TK78_RS34575 57da71843f936301f2615bef66ec38c8 1000 SMART SM00758 46 186 8.0E-27 T 09-03-2017 IPR011658 PA14 domain TK78_RS34575 57da71843f936301f2615bef66ec38c8 1000 Gene3D G3DSA:2.60.120.260 676 806 5.8E-27 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS34575 57da71843f936301f2615bef66ec38c8 1000 SUPERFAMILY SSF56988 104 209 1.96E-10 T 09-03-2017 TK78_RS11645 3521e6ab3b8ba68106f11e7d7433ce5c 235 TIGRFAM TIGR03177 pilus_cpaB: Flp pilus assembly protein CpaB 10 216 9.4E-22 T 09-03-2017 IPR017592 Pilus assembly, Flp-type CpaB TK78_RS11645 3521e6ab3b8ba68106f11e7d7433ce5c 235 Pfam PF16976 Flp pilus assembly protein RcpC/CpaB 107 213 1.8E-17 T 09-03-2017 IPR031571 Flp pilus assembly protein RcpC/CpaB domain TK78_RS30720 82e23f979a44e073b864b81632011d51 556 Pfam PF00391 PEP-utilising enzyme, mobile domain 150 221 9.8E-22 T 09-03-2017 IPR008279 PEP-utilising enzyme, mobile domain GO:0016310|GO:0016772 TK78_RS30720 82e23f979a44e073b864b81632011d51 556 ProSitePatterns PS00370 PEP-utilizing enzymes phosphorylation site signature. 181 192 - T 09-03-2017 IPR018274 PEP-utilising enzyme, active site GO:0016310|GO:0016772 TK78_RS30720 82e23f979a44e073b864b81632011d51 556 TIGRFAM TIGR01417 PTS_I_fam: phosphoenolpyruvate-protein phosphotransferase 5 546 3.2E-128 T 09-03-2017 IPR006318 Phosphotransferase system, enzyme I-like GO:0016772 TK78_RS30720 82e23f979a44e073b864b81632011d51 556 SUPERFAMILY SSF47831 30 140 1.7E-20 T 09-03-2017 IPR008731 Phosphotransferase system, enzyme I N-terminal GO:0009401 TK78_RS30720 82e23f979a44e073b864b81632011d51 556 PIRSF PIRSF000732 1 556 2.6E-170 T 09-03-2017 IPR024692 Phosphotransferase system, enzyme I GO:0008965|GO:0009401 TK78_RS30720 82e23f979a44e073b864b81632011d51 556 Pfam PF05524 PEP-utilising enzyme, N-terminal 6 123 2.6E-21 T 09-03-2017 IPR008731 Phosphotransferase system, enzyme I N-terminal GO:0009401 TK78_RS30720 82e23f979a44e073b864b81632011d51 556 SUPERFAMILY SSF52009 123 237 1.44E-30 T 09-03-2017 IPR008279 PEP-utilising enzyme, mobile domain GO:0016310|GO:0016772 TK78_RS30720 82e23f979a44e073b864b81632011d51 556 PRINTS PR01736 Phosphoenolpyruvate-protein phosphotransferase signature 484 496 5.7E-18 T 09-03-2017 TK78_RS30720 82e23f979a44e073b864b81632011d51 556 PRINTS PR01736 Phosphoenolpyruvate-protein phosphotransferase signature 431 446 5.7E-18 T 09-03-2017 TK78_RS30720 82e23f979a44e073b864b81632011d51 556 PRINTS PR01736 Phosphoenolpyruvate-protein phosphotransferase signature 285 304 5.7E-18 T 09-03-2017 TK78_RS30720 82e23f979a44e073b864b81632011d51 556 PRINTS PR01736 Phosphoenolpyruvate-protein phosphotransferase signature 448 463 5.7E-18 T 09-03-2017 TK78_RS30720 82e23f979a44e073b864b81632011d51 556 Pfam PF02896 PEP-utilising enzyme, TIM barrel domain 252 524 3.5E-78 T 09-03-2017 IPR000121 PEP-utilising enzyme, C-terminal GO:0016310|GO:0016772 TK78_RS30720 82e23f979a44e073b864b81632011d51 556 Gene3D G3DSA:3.50.30.10 130 243 4.0E-34 T 09-03-2017 IPR008279 PEP-utilising enzyme, mobile domain GO:0016310|GO:0016772 TK78_RS30720 82e23f979a44e073b864b81632011d51 556 Gene3D G3DSA:3.20.20.60 250 551 3.0E-87 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS30720 82e23f979a44e073b864b81632011d51 556 SUPERFAMILY SSF51621 248 533 2.49E-84 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS30720 82e23f979a44e073b864b81632011d51 556 Gene3D G3DSA:1.10.274.10 28 129 1.1E-20 T 09-03-2017 IPR008731 Phosphotransferase system, enzyme I N-terminal GO:0009401 TK78_RS30720 82e23f979a44e073b864b81632011d51 556 ProSitePatterns PS00742 PEP-utilizing enzymes signature 2. 431 449 - T 09-03-2017 IPR023151 PEP-utilising enzyme, conserved site GO:0016772 TK78_RS19920 c67ac3571e5d844044ec56c15b18e7c5 269 TIGRFAM TIGR00112 proC: pyrroline-5-carboxylate reductase 5 264 6.2E-84 T 09-03-2017 IPR000304 Pyrroline-5-carboxylate reductase GO:0004735|GO:0006561|GO:0055114 KEGG: 00330+1.5.1.2|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344 TK78_RS19920 c67ac3571e5d844044ec56c15b18e7c5 269 Pfam PF14748 Pyrroline-5-carboxylate reductase dimerisation 160 264 1.5E-37 T 09-03-2017 IPR029036 Pyrroline-5-carboxylate reductase, dimerisation domain KEGG: 00330+1.5.1.2|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344|Reactome: R-HSA-70614 TK78_RS19920 c67ac3571e5d844044ec56c15b18e7c5 269 SUPERFAMILY SSF51735 4 158 5.44E-36 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS19920 c67ac3571e5d844044ec56c15b18e7c5 269 PIRSF PIRSF000193 2 267 5.2E-81 T 09-03-2017 IPR000304 Pyrroline-5-carboxylate reductase GO:0004735|GO:0006561|GO:0055114 KEGG: 00330+1.5.1.2|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344 TK78_RS19920 c67ac3571e5d844044ec56c15b18e7c5 269 Gene3D G3DSA:1.10.3730.10 159 264 1.1E-40 T 09-03-2017 IPR029036 Pyrroline-5-carboxylate reductase, dimerisation domain KEGG: 00330+1.5.1.2|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344|Reactome: R-HSA-70614 TK78_RS19920 c67ac3571e5d844044ec56c15b18e7c5 269 Pfam PF03807 NADP oxidoreductase coenzyme F420-dependent 5 97 2.6E-24 T 09-03-2017 IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal TK78_RS19920 c67ac3571e5d844044ec56c15b18e7c5 269 SUPERFAMILY SSF48179 159 265 3.91E-35 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS19920 c67ac3571e5d844044ec56c15b18e7c5 269 Gene3D G3DSA:3.40.50.720 2 157 1.7E-46 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS19920 c67ac3571e5d844044ec56c15b18e7c5 269 ProSitePatterns PS00521 Delta 1-pyrroline-5-carboxylate reductase signature. 220 242 - T 09-03-2017 IPR000304 Pyrroline-5-carboxylate reductase GO:0004735|GO:0006561|GO:0055114 KEGG: 00330+1.5.1.2|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344 TK78_RS19920 c67ac3571e5d844044ec56c15b18e7c5 269 Hamap MF_01925 Pyrroline-5-carboxylate reductase [proC]. 3 264 27.632 T 09-03-2017 IPR000304 Pyrroline-5-carboxylate reductase GO:0004735|GO:0006561|GO:0055114 KEGG: 00330+1.5.1.2|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344 TK78_RS02960 e7f66cac103202e50346bbfd37eac68e 316 Gene3D G3DSA:3.40.50.720 12 305 1.2E-26 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS02960 e7f66cac103202e50346bbfd37eac68e 316 SUPERFAMILY SSF51735 12 312 1.09E-39 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS02960 e7f66cac103202e50346bbfd37eac68e 316 Pfam PF01370 NAD dependent epimerase/dehydratase family 12 217 9.4E-10 T 09-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 TK78_RS14645 4c543c9f5d200bc3085bf0756b0524e7 271 Pfam PF11228 Protein of unknown function (DUF3027) 3 224 1.7E-83 T 09-03-2017 IPR021391 Protein of unknown function DUF3027 TK78_RS08145 f47f095d66ddce7610e13b2acb8cc75f 256 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 59 75 3.4E-20 T 09-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 TK78_RS08145 f47f095d66ddce7610e13b2acb8cc75f 256 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 139 151 3.4E-20 T 09-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 TK78_RS08145 f47f095d66ddce7610e13b2acb8cc75f 256 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 187 206 3.4E-20 T 09-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 TK78_RS08145 f47f095d66ddce7610e13b2acb8cc75f 256 Pfam PF10502 Signal peptidase, peptidase S26 137 226 2.0E-4 T 09-03-2017 IPR019533 Peptidase S26 TK78_RS08145 f47f095d66ddce7610e13b2acb8cc75f 256 TIGRFAM TIGR02227 sigpep_I_bact: signal peptidase I 46 232 2.1E-34 T 09-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 TK78_RS08145 f47f095d66ddce7610e13b2acb8cc75f 256 ProSitePatterns PS00761 Signal peptidases I signature 3. 192 205 - T 09-03-2017 IPR019758 Peptidase S26A, signal peptidase I, conserved site GO:0008236|GO:0016021 TK78_RS08145 f47f095d66ddce7610e13b2acb8cc75f 256 Pfam PF00717 Peptidase S24-like 66 106 2.3E-11 T 09-03-2017 IPR019759 Peptidase S24/S26A/S26B TK78_RS08145 f47f095d66ddce7610e13b2acb8cc75f 256 ProSitePatterns PS00501 Signal peptidases I serine active site. 68 75 - T 09-03-2017 IPR019756 Peptidase S26A, signal peptidase I, serine active site GO:0008236|GO:0016021 Reactome: R-HSA-1799339|Reactome: R-HSA-381771|Reactome: R-HSA-400511|Reactome: R-HSA-422085 TK78_RS08145 f47f095d66ddce7610e13b2acb8cc75f 256 SUPERFAMILY SSF51306 58 106 1.01E-44 T 09-03-2017 IPR015927 Peptidase S24/S26A/S26B/S26C TK78_RS08145 f47f095d66ddce7610e13b2acb8cc75f 256 SUPERFAMILY SSF51306 134 239 1.01E-44 T 09-03-2017 IPR015927 Peptidase S24/S26A/S26B/S26C TK78_RS08145 f47f095d66ddce7610e13b2acb8cc75f 256 Gene3D G3DSA:2.10.109.10 187 239 8.1E-36 T 09-03-2017 IPR028360 Peptidase S24/S26, beta-ribbon domain TK78_RS08145 f47f095d66ddce7610e13b2acb8cc75f 256 Gene3D G3DSA:2.10.109.10 56 149 8.1E-36 T 09-03-2017 IPR028360 Peptidase S24/S26, beta-ribbon domain TK78_RS30680 9c09f0f4c9773add241d05ccdbb830b8 396 Gene3D G3DSA:3.40.47.10 193 223 1.8E-22 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS30680 9c09f0f4c9773add241d05ccdbb830b8 396 Gene3D G3DSA:3.40.47.10 21 112 1.8E-22 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS30680 9c09f0f4c9773add241d05ccdbb830b8 396 SUPERFAMILY SSF53901 277 385 4.84E-20 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS30680 9c09f0f4c9773add241d05ccdbb830b8 396 SUPERFAMILY SSF53901 4 229 1.63E-33 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS30680 9c09f0f4c9773add241d05ccdbb830b8 396 Gene3D G3DSA:3.40.47.10 276 378 1.5E-6 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS30680 9c09f0f4c9773add241d05ccdbb830b8 396 Pfam PF00108 Thiolase, N-terminal domain 26 111 7.8E-7 T 09-03-2017 IPR020616 Thiolase, N-terminal GO:0008152|GO:0016747 TK78_RS30680 9c09f0f4c9773add241d05ccdbb830b8 396 PIRSF PIRSF000429 1 396 1.2E-32 T 09-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 TK78_RS20600 e3d9b7b57e7040154ea19d4ae30fd4f1 104 Pfam PF13560 Helix-turn-helix domain 11 47 2.3E-8 T 09-03-2017 TK78_RS20600 e3d9b7b57e7040154ea19d4ae30fd4f1 104 Pfam PF04149 Domain of unknown function (DUF397) 48 100 6.9E-20 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS20600 e3d9b7b57e7040154ea19d4ae30fd4f1 104 SMART SM00530 13 74 0.0018 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS20600 e3d9b7b57e7040154ea19d4ae30fd4f1 104 SUPERFAMILY SSF47413 10 47 2.22E-8 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS20600 e3d9b7b57e7040154ea19d4ae30fd4f1 104 Gene3D G3DSA:1.10.260.40 9 48 3.9E-9 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS09325 11f5ab6242c716eb03831c0daae032dc 681 Gene3D G3DSA:2.60.120.260 583 681 8.1E-16 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS09325 11f5ab6242c716eb03831c0daae032dc 681 Pfam PF01447 Thermolysin metallopeptidase, catalytic domain 234 377 1.9E-45 T 09-03-2017 IPR013856 Peptidase M4 domain GO:0004222 TK78_RS09325 11f5ab6242c716eb03831c0daae032dc 681 SUPERFAMILY SSF55486 230 555 1.47E-79 T 09-03-2017 TK78_RS09325 11f5ab6242c716eb03831c0daae032dc 681 Pfam PF01483 Proprotein convertase P-domain 602 681 6.5E-20 T 09-03-2017 IPR002884 Proprotein convertase, P GO:0004252|GO:0006508 TK78_RS09325 11f5ab6242c716eb03831c0daae032dc 681 SUPERFAMILY SSF49785 574 681 4.0E-24 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS09325 11f5ab6242c716eb03831c0daae032dc 681 Gene3D G3DSA:3.10.170.10 232 380 2.2E-42 T 09-03-2017 IPR013856 Peptidase M4 domain GO:0004222 TK78_RS09325 11f5ab6242c716eb03831c0daae032dc 681 Gene3D G3DSA:1.10.390.10 382 554 4.7E-50 T 09-03-2017 TK78_RS09325 11f5ab6242c716eb03831c0daae032dc 681 Pfam PF07504 Fungalysin/Thermolysin Propeptide Motif 90 137 1.3E-13 T 09-03-2017 IPR011096 FTP domain TK78_RS09325 11f5ab6242c716eb03831c0daae032dc 681 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 368 384 5.6E-16 T 09-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 TK78_RS09325 11f5ab6242c716eb03831c0daae032dc 681 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 332 352 5.6E-16 T 09-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 TK78_RS09325 11f5ab6242c716eb03831c0daae032dc 681 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 456 472 5.6E-16 T 09-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 TK78_RS09325 11f5ab6242c716eb03831c0daae032dc 681 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 389 400 5.6E-16 T 09-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 TK78_RS09325 11f5ab6242c716eb03831c0daae032dc 681 Pfam PF02868 Thermolysin metallopeptidase, alpha-helical domain 380 554 1.8E-51 T 09-03-2017 IPR001570 Peptidase M4, C-terminal GO:0004222 TK78_RS03390 bdaa4e8e402e78a4aad77d26c7eb4cda 84 Pfam PF02467 Transcription factor WhiB 13 76 2.1E-23 T 09-03-2017 IPR003482 Transcription factor WhiB TK78_RS03390 bdaa4e8e402e78a4aad77d26c7eb4cda 84 Hamap MF_01479 Transcriptional regulator WhiB [whiB]. 1 81 17.148 T 09-03-2017 IPR003482 Transcription factor WhiB TK78_RS31670 8a2c3f9537ccf097f406c57bf7ce3034 412 Pfam PF08245 Mur ligase middle domain 65 266 2.1E-11 T 09-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 TK78_RS31670 8a2c3f9537ccf097f406c57bf7ce3034 412 Pfam PF08353 Domain of unknown function (DUF1727) 304 403 3.7E-22 T 09-03-2017 IPR013564 Domain of unknown function DUF1727 TK78_RS31670 8a2c3f9537ccf097f406c57bf7ce3034 412 Gene3D G3DSA:3.40.1190.10 47 284 1.9E-37 T 09-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 TK78_RS31670 8a2c3f9537ccf097f406c57bf7ce3034 412 SUPERFAMILY SSF53623 47 281 3.92E-29 T 09-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 TK78_RS09500 887e7a1c3dad9f803232a5d49cdbfd9b 116 Pfam PF12823 Domain of unknown function (DUF3817) 9 96 9.1E-19 T 09-03-2017 IPR023845 Domain of unknown function DUF3817, transmembrane TK78_RS09500 887e7a1c3dad9f803232a5d49cdbfd9b 116 TIGRFAM TIGR03954 integ_memb_HG: integral membrane protein 12 95 4.0E-21 T 09-03-2017 IPR023845 Domain of unknown function DUF3817, transmembrane TK78_RS32255 4c695dfc6ac73a1144b7706b8d46df5d 228 Pfam PF08713 DNA alkylation repair enzyme 14 215 9.2E-23 T 09-03-2017 IPR014825 DNA alkylation repair enzyme TK78_RS32255 4c695dfc6ac73a1144b7706b8d46df5d 228 SUPERFAMILY SSF48371 11 227 2.01E-64 T 09-03-2017 IPR016024 Armadillo-type fold GO:0005488 TK78_RS24060 89a372ca889faccd966689899cc6dea2 554 Gene3D G3DSA:3.40.50.300 320 513 3.2E-43 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24060 89a372ca889faccd966689899cc6dea2 554 Gene3D G3DSA:3.40.50.300 8 285 1.1E-54 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24060 89a372ca889faccd966689899cc6dea2 554 SUPERFAMILY SSF52540 8 239 1.97E-48 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24060 89a372ca889faccd966689899cc6dea2 554 ProSitePatterns PS00211 ABC transporters family signature. 160 174 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS24060 89a372ca889faccd966689899cc6dea2 554 SUPERFAMILY SSF52540 307 515 3.38E-46 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24060 89a372ca889faccd966689899cc6dea2 554 TIGRFAM TIGR03719 ABC_ABC_ChvD: ATP-binding cassette protein, ChvD family 3 551 3.4E-273 T 09-03-2017 IPR022374 ABC transporter, ATP-binding protein, ChvD TK78_RS24060 89a372ca889faccd966689899cc6dea2 554 Pfam PF00005 ABC transporter 338 471 3.7E-21 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS24060 89a372ca889faccd966689899cc6dea2 554 Pfam PF00005 ABC transporter 21 188 2.7E-26 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS24060 89a372ca889faccd966689899cc6dea2 554 ProSitePatterns PS00211 ABC transporters family signature. 443 457 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS24060 89a372ca889faccd966689899cc6dea2 554 Pfam PF12848 ABC transporter 227 296 9.5E-13 T 09-03-2017 IPR032781 ABC-transporter extension domain TK78_RS24060 89a372ca889faccd966689899cc6dea2 554 SMART SM00382 346 524 2.4E-8 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS24060 89a372ca889faccd966689899cc6dea2 554 SMART SM00382 30 249 8.5E-11 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS27340 81b8fa64d57204ada2f5c847a19d2071 269 Gene3D G3DSA:3.20.20.70 2 259 3.7E-94 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS27340 81b8fa64d57204ada2f5c847a19d2071 269 SUPERFAMILY SSF51366 12 257 1.65E-77 T 09-03-2017 IPR011060 Ribulose-phosphate binding barrel GO:0003824|GO:0008152 TK78_RS27340 81b8fa64d57204ada2f5c847a19d2071 269 Hamap MF_00134_B Indole-3-glycerol phosphate synthase [trpC]. 2 257 33.766 T 09-03-2017 IPR013798 Indole-3-glycerol phosphate synthase GO:0004425 KEGG: 00400+4.1.1.48 TK78_RS27340 81b8fa64d57204ada2f5c847a19d2071 269 Pfam PF00218 Indole-3-glycerol phosphate synthase 4 255 6.4E-80 T 09-03-2017 IPR013798 Indole-3-glycerol phosphate synthase GO:0004425 KEGG: 00400+4.1.1.48 TK78_RS27340 81b8fa64d57204ada2f5c847a19d2071 269 Hamap MF_00134_A Indole-3-glycerol phosphate synthase [trpC]. 34 253 29.282 T 09-03-2017 IPR013798 Indole-3-glycerol phosphate synthase GO:0004425 KEGG: 00400+4.1.1.48 TK78_RS27340 81b8fa64d57204ada2f5c847a19d2071 269 ProSitePatterns PS00614 Indole-3-glycerol phosphate synthase signature. 51 68 - T 09-03-2017 IPR001468 Indole-3-glycerol phosphate synthase, conserved site GO:0004425|GO:0006568 KEGG: 00400+4.1.1.48 TK78_RS32430 73f7eca701fad58e110ca6367fc8fa1f 72 Pfam PF03966 Trm112p-like protein 5 43 2.0E-8 T 09-03-2017 IPR005651 Uncharacterised protein family UPF0434/Trm112 TK78_RS32430 73f7eca701fad58e110ca6367fc8fa1f 72 Gene3D G3DSA:2.20.25.10 10 63 6.6E-18 T 09-03-2017 TK78_RS32430 73f7eca701fad58e110ca6367fc8fa1f 72 SUPERFAMILY SSF158997 1 56 2.22E-16 T 09-03-2017 TK78_RS26515 452ba3d8e920fe9624207f13bb8d4ac4 170 Gene3D G3DSA:1.10.10.10 22 156 1.2E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS26515 452ba3d8e920fe9624207f13bb8d4ac4 170 Pfam PF12802 MarR family 43 106 1.2E-12 T 09-03-2017 TK78_RS26515 452ba3d8e920fe9624207f13bb8d4ac4 170 SUPERFAMILY SSF46785 21 156 2.32E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS26515 452ba3d8e920fe9624207f13bb8d4ac4 170 SMART SM00347 38 142 2.6E-14 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS16695 a7ce90654e2d51f92d04b0f75836ee0e 962 PRINTS PR00364 Disease resistance protein signature 354 368 1.1E-5 T 09-03-2017 TK78_RS16695 a7ce90654e2d51f92d04b0f75836ee0e 962 PRINTS PR00364 Disease resistance protein signature 204 219 1.1E-5 T 09-03-2017 TK78_RS16695 a7ce90654e2d51f92d04b0f75836ee0e 962 PRINTS PR00364 Disease resistance protein signature 275 289 1.1E-5 T 09-03-2017 TK78_RS16695 a7ce90654e2d51f92d04b0f75836ee0e 962 SUPERFAMILY SSF48452 835 946 1.9E-8 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS16695 a7ce90654e2d51f92d04b0f75836ee0e 962 Pfam PF13676 TIR domain 8 108 1.0E-25 T 09-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 TK78_RS16695 a7ce90654e2d51f92d04b0f75836ee0e 962 Pfam PF00931 NB-ARC domain 188 313 6.1E-9 T 09-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 TK78_RS16695 a7ce90654e2d51f92d04b0f75836ee0e 962 SUPERFAMILY SSF48452 540 659 3.85E-9 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS16695 a7ce90654e2d51f92d04b0f75836ee0e 962 SUPERFAMILY SSF48452 708 827 3.38E-12 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS16695 a7ce90654e2d51f92d04b0f75836ee0e 962 SUPERFAMILY SSF52200 7 107 4.84E-19 T 09-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 TK78_RS16695 a7ce90654e2d51f92d04b0f75836ee0e 962 Gene3D G3DSA:3.40.50.10140 8 107 3.2E-11 T 09-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 TK78_RS16695 a7ce90654e2d51f92d04b0f75836ee0e 962 Pfam PF13374 Tetratricopeptide repeat 630 670 2.2E-10 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS16695 a7ce90654e2d51f92d04b0f75836ee0e 962 Pfam PF13374 Tetratricopeptide repeat 588 629 6.0E-7 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS16695 a7ce90654e2d51f92d04b0f75836ee0e 962 Pfam PF13424 Tetratricopeptide repeat 676 746 1.6E-13 T 09-03-2017 TK78_RS16695 a7ce90654e2d51f92d04b0f75836ee0e 962 Pfam PF13424 Tetratricopeptide repeat 841 913 1.4E-10 T 09-03-2017 TK78_RS16695 a7ce90654e2d51f92d04b0f75836ee0e 962 Pfam PF13424 Tetratricopeptide repeat 757 830 2.3E-10 T 09-03-2017 TK78_RS16695 a7ce90654e2d51f92d04b0f75836ee0e 962 Gene3D G3DSA:1.25.40.10 595 911 1.5E-19 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS16695 a7ce90654e2d51f92d04b0f75836ee0e 962 SUPERFAMILY SSF52540 172 384 4.37E-25 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS16695 a7ce90654e2d51f92d04b0f75836ee0e 962 SMART SM00255 5 134 1.9E-7 T 09-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 TK78_RS27155 0c962e2776d4992d8671417bbd5400d0 196 Hamap MF_00161 Lipoprotein signal peptidase [lspA]. 38 190 14.596 T 09-03-2017 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 TK78_RS27155 0c962e2776d4992d8671417bbd5400d0 196 TIGRFAM TIGR00077 lspA: signal peptidase II 38 184 4.6E-24 T 09-03-2017 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 TK78_RS27155 0c962e2776d4992d8671417bbd5400d0 196 ProSitePatterns PS00855 Signal peptidases II signature. 130 142 - T 09-03-2017 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 TK78_RS27155 0c962e2776d4992d8671417bbd5400d0 196 Pfam PF01252 Signal peptidase (SPase) II 47 184 4.5E-29 T 09-03-2017 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 TK78_RS27155 0c962e2776d4992d8671417bbd5400d0 196 PRINTS PR00781 Lipoprotein signal peptidase family (A8) signature 165 181 4.8E-16 T 09-03-2017 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 TK78_RS27155 0c962e2776d4992d8671417bbd5400d0 196 PRINTS PR00781 Lipoprotein signal peptidase family (A8) signature 127 142 4.8E-16 T 09-03-2017 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 TK78_RS27155 0c962e2776d4992d8671417bbd5400d0 196 PRINTS PR00781 Lipoprotein signal peptidase family (A8) signature 85 93 4.8E-16 T 09-03-2017 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 TK78_RS23260 9738432ccf97db9a6c5012cb424a7a72 334 PIRSF PIRSF005739 2 333 1.4E-48 T 09-03-2017 IPR016461 O-methyltransferase COMT-type GO:0008168 TK78_RS23260 9738432ccf97db9a6c5012cb424a7a72 334 Pfam PF16864 Dimerisation domain 10 84 9.2E-8 T 09-03-2017 IPR031725 Acetylserotonin O-methyltransferase, dimerisation domain TK78_RS23260 9738432ccf97db9a6c5012cb424a7a72 334 SUPERFAMILY SSF53335 93 328 8.44E-42 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS23260 9738432ccf97db9a6c5012cb424a7a72 334 Gene3D G3DSA:3.40.50.150 96 331 1.0E-58 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS23260 9738432ccf97db9a6c5012cb424a7a72 334 SUPERFAMILY SSF46785 5 88 5.99E-16 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS23260 9738432ccf97db9a6c5012cb424a7a72 334 Pfam PF00891 O-methyltransferase 100 316 1.1E-46 T 09-03-2017 IPR001077 O-methyltransferase, family 2 GO:0008171 TK78_RS23260 9738432ccf97db9a6c5012cb424a7a72 334 Gene3D G3DSA:1.10.10.10 5 95 2.1E-28 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS10135 7f34845f65407b5d2766e9851dd84380 452 SUPERFAMILY SSF55874 331 443 1.45E-9 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS10135 7f34845f65407b5d2766e9851dd84380 452 Pfam PF07730 Histidine kinase 238 303 3.9E-20 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS13105 2065e41c16829783e6302d75bae4ad24 185 PIRSF PIRSF002161 2 185 6.3E-64 T 09-03-2017 IPR002132 Ribosomal protein L5 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13105 2065e41c16829783e6302d75bae4ad24 185 ProSitePatterns PS00358 Ribosomal protein L5 signature. 62 78 - T 09-03-2017 IPR020929 Ribosomal protein L5, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13105 2065e41c16829783e6302d75bae4ad24 185 Pfam PF00673 ribosomal L5P family C-terminus 89 182 1.0E-39 T 09-03-2017 IPR031309 Ribosomal protein L5, C-terminal Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13105 2065e41c16829783e6302d75bae4ad24 185 Hamap MF_01333_B 50S ribosomal protein L5 [rplE]. 6 184 43.573 T 09-03-2017 IPR020930 Ribosomal protein L5, bacterial-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13105 2065e41c16829783e6302d75bae4ad24 185 Pfam PF00281 Ribosomal protein L5 29 85 1.1E-28 T 09-03-2017 IPR031310 Ribosomal protein L5, N-terminal Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13105 2065e41c16829783e6302d75bae4ad24 185 SUPERFAMILY SSF55282 8 183 6.36E-76 T 09-03-2017 IPR022803 Ribosomal protein L5 domain Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13105 2065e41c16829783e6302d75bae4ad24 185 Gene3D G3DSA:3.30.1440.10 7 183 7.7E-76 T 09-03-2017 IPR022803 Ribosomal protein L5 domain Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS24065 915e7f130091b70142c78bf7a38c7450 140 Pfam PF03061 Thioesterase superfamily 18 101 1.1E-17 T 09-03-2017 IPR006683 Thioesterase domain Reactome: R-HSA-75105 TK78_RS24065 915e7f130091b70142c78bf7a38c7450 140 Gene3D G3DSA:3.10.129.10 3 135 1.4E-47 T 09-03-2017 IPR029069 HotDog domain TK78_RS24065 915e7f130091b70142c78bf7a38c7450 140 SUPERFAMILY SSF54637 4 133 1.08E-33 T 09-03-2017 IPR029069 HotDog domain TK78_RS32745 e7826899a20bd09d17abd4fd128aa893 325 Pfam PF00356 Bacterial regulatory proteins, lacI family 1 45 9.1E-13 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS32745 e7826899a20bd09d17abd4fd128aa893 325 Gene3D G3DSA:3.40.50.2300 170 300 4.6E-38 T 09-03-2017 TK78_RS32745 e7826899a20bd09d17abd4fd128aa893 325 SUPERFAMILY SSF53822 58 320 2.36E-59 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS32745 e7826899a20bd09d17abd4fd128aa893 325 SMART SM00354 1 68 5.3E-19 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS32745 e7826899a20bd09d17abd4fd128aa893 325 Pfam PF13377 Periplasmic binding protein-like domain 165 319 2.1E-25 T 09-03-2017 TK78_RS32745 e7826899a20bd09d17abd4fd128aa893 325 ProSitePatterns PS00356 LacI-type HTH domain signature. 1 19 - T 09-03-2017 TK78_RS32745 e7826899a20bd09d17abd4fd128aa893 325 Gene3D G3DSA:3.40.50.2300 49 169 9.6E-40 T 09-03-2017 TK78_RS32745 e7826899a20bd09d17abd4fd128aa893 325 SUPERFAMILY SSF47413 1 56 1.29E-13 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS32745 e7826899a20bd09d17abd4fd128aa893 325 Gene3D G3DSA:1.10.260.40 1 48 1.8E-20 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS32445 84bb151a9781a6821270a596c6366a6c 442 Gene3D G3DSA:3.30.559.10 126 185 3.8E-4 T 09-03-2017 IPR023213 Chloramphenicol acetyltransferase-like domain Reactome: R-HSA-389661 TK78_RS32445 84bb151a9781a6821270a596c6366a6c 442 SUPERFAMILY SSF52777 235 437 3.89E-6 T 09-03-2017 TK78_RS32445 84bb151a9781a6821270a596c6366a6c 442 SUPERFAMILY SSF52777 39 186 7.34E-15 T 09-03-2017 TK78_RS11160 65e12fd639e280bb7b29340b531bc39c 276 Gene3D G3DSA:3.40.50.1820 10 275 1.8E-36 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS11160 65e12fd639e280bb7b29340b531bc39c 276 SUPERFAMILY SSF53474 7 275 5.79E-35 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS11160 65e12fd639e280bb7b29340b531bc39c 276 Pfam PF12697 Alpha/beta hydrolase family 45 268 1.5E-15 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS19080 6633837bd4825b4ba69090b549e89f67 254 TIGRFAM TIGR00453 ispD: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 18 245 6.6E-71 T 09-03-2017 IPR001228 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase GO:0008299|GO:0050518 KEGG: 00900+2.7.7.60|MetaCyc: PWY-7560 TK78_RS19080 6633837bd4825b4ba69090b549e89f67 254 Gene3D G3DSA:3.90.550.10 15 250 4.8E-69 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS19080 6633837bd4825b4ba69090b549e89f67 254 SUPERFAMILY SSF53448 16 245 2.19E-52 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS19080 6633837bd4825b4ba69090b549e89f67 254 ProSitePatterns PS01295 4-diphosphocytidyl-2C-methyl-D-erythritol synthase signature. 116 123 - T 09-03-2017 IPR018294 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, conserved site GO:0003824|GO:0008299 KEGG: 00900+2.7.7.60|MetaCyc: PWY-7560 TK78_RS19080 6633837bd4825b4ba69090b549e89f67 254 Pfam PF01128 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 17 246 2.1E-65 T 09-03-2017 IPR001228 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase GO:0008299|GO:0050518 KEGG: 00900+2.7.7.60|MetaCyc: PWY-7560 TK78_RS19080 6633837bd4825b4ba69090b549e89f67 254 Hamap MF_00108 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [ispD]. 15 248 29.056 T 09-03-2017 IPR001228 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase GO:0008299|GO:0050518 KEGG: 00900+2.7.7.60|MetaCyc: PWY-7560 TK78_RS28255 17e2adee141c0857190507a1bc9af01f 219 SUPERFAMILY SSF53639 8 218 3.34E-59 T 09-03-2017 IPR001303 Class II aldolase/adducin N-terminal TK78_RS28255 17e2adee141c0857190507a1bc9af01f 219 SMART SM01007 14 187 1.9E-56 T 09-03-2017 IPR001303 Class II aldolase/adducin N-terminal TK78_RS28255 17e2adee141c0857190507a1bc9af01f 219 Gene3D G3DSA:3.40.225.10 9 218 6.6E-68 T 09-03-2017 IPR001303 Class II aldolase/adducin N-terminal TK78_RS28255 17e2adee141c0857190507a1bc9af01f 219 Pfam PF00596 Class II Aldolase and Adducin N-terminal domain 15 186 1.4E-45 T 09-03-2017 IPR001303 Class II aldolase/adducin N-terminal TK78_RS04520 45b0fed32c49e7311171842f0a11e0cd 239 SUPERFAMILY SSF46689 2 66 5.99E-16 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS04520 45b0fed32c49e7311171842f0a11e0cd 239 Gene3D G3DSA:1.10.10.60 2 43 1.5E-17 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS04520 45b0fed32c49e7311171842f0a11e0cd 239 ProSitePatterns PS01081 TetR-type HTH domain signature. 17 48 - T 09-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site TK78_RS04520 45b0fed32c49e7311171842f0a11e0cd 239 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 26 49 2.0E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS04520 45b0fed32c49e7311171842f0a11e0cd 239 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 5 18 2.0E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS04520 45b0fed32c49e7311171842f0a11e0cd 239 Pfam PF00440 Bacterial regulatory proteins, tetR family 7 46 6.9E-16 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS04520 45b0fed32c49e7311171842f0a11e0cd 239 Gene3D G3DSA:1.10.357.10 44 179 4.6E-35 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS20645 487dce9d500f3e7d73d1db849bae7663 285 Pfam PF13560 Helix-turn-helix domain 13 69 1.5E-16 T 09-03-2017 TK78_RS20645 487dce9d500f3e7d73d1db849bae7663 285 SMART SM00530 17 72 5.2E-13 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS20645 487dce9d500f3e7d73d1db849bae7663 285 SUPERFAMILY SSF47413 10 68 3.58E-13 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS20645 487dce9d500f3e7d73d1db849bae7663 285 Gene3D G3DSA:1.10.260.40 7 73 1.5E-17 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS19280 36cb1f3e1e41ff7e648603f6b7931672 176 SUPERFAMILY SSF55729 10 165 1.5E-28 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS19280 36cb1f3e1e41ff7e648603f6b7931672 176 Pfam PF13302 Acetyltransferase (GNAT) domain 18 157 4.8E-22 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS19280 36cb1f3e1e41ff7e648603f6b7931672 176 Gene3D G3DSA:3.40.630.30 9 174 2.7E-35 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS03125 91793a483fe59da3c3ef1bc208f3c066 465 SUPERFAMILY SSF53383 38 441 4.13E-108 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS03125 91793a483fe59da3c3ef1bc208f3c066 465 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 237 275 - T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS03125 91793a483fe59da3c3ef1bc208f3c066 465 Pfam PF00202 Aminotransferase class-III 45 439 5.8E-90 T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS03125 91793a483fe59da3c3ef1bc208f3c066 465 Gene3D G3DSA:3.90.1150.10 327 441 2.3E-33 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS03125 91793a483fe59da3c3ef1bc208f3c066 465 Gene3D G3DSA:3.90.1150.10 25 79 2.3E-33 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS03125 91793a483fe59da3c3ef1bc208f3c066 465 Gene3D G3DSA:3.40.640.10 80 326 3.7E-71 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS26005 39e323e2c0da00035a00914c615ee79a 217 SUPERFAMILY SSF51569 15 214 6.41E-66 T 09-03-2017 TK78_RS26005 39e323e2c0da00035a00914c615ee79a 217 TIGRFAM TIGR01182 eda: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase 15 214 2.3E-75 T 09-03-2017 IPR000887 KDPG/KHG aldolase GO:0008152|GO:0016829 KEGG: 00030+4.1.2.14|MetaCyc: PWY-2221|MetaCyc: PWY-6507|MetaCyc: PWY-7242|MetaCyc: PWY-7310|MetaCyc: PWY-7562 TK78_RS26005 39e323e2c0da00035a00914c615ee79a 217 ProSitePatterns PS00159 KDPG and KHG aldolases active site. 45 54 - T 09-03-2017 IPR031337 KDPG/KHG aldolase, active site 1 KEGG: 00030+4.1.2.14|KEGG: 00330+4.1.3.16|KEGG: 00630+4.1.3.16|MetaCyc: PWY-2221|MetaCyc: PWY-6507|MetaCyc: PWY-7242|MetaCyc: PWY-7310|MetaCyc: PWY-7562 TK78_RS26005 39e323e2c0da00035a00914c615ee79a 217 Pfam PF01081 KDPG and KHG aldolase 15 208 1.4E-69 T 09-03-2017 IPR000887 KDPG/KHG aldolase GO:0008152|GO:0016829 KEGG: 00030+4.1.2.14|MetaCyc: PWY-2221|MetaCyc: PWY-6507|MetaCyc: PWY-7242|MetaCyc: PWY-7310|MetaCyc: PWY-7562 TK78_RS26005 39e323e2c0da00035a00914c615ee79a 217 Gene3D G3DSA:3.20.20.70 16 215 5.1E-75 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS26005 39e323e2c0da00035a00914c615ee79a 217 ProSitePatterns PS00160 KDPG and KHG aldolases Schiff-base forming residue. 133 146 - T 09-03-2017 IPR031338 KDPG/KHG aldolase, active site 2 KEGG: 00030+4.1.2.14|MetaCyc: PWY-2221|MetaCyc: PWY-6507|MetaCyc: PWY-7242|MetaCyc: PWY-7310|MetaCyc: PWY-7562 TK78_RS01655 d100ff53a6bb9a542bf6521d3a7561e4 287 ProSitePatterns PS00497 Tyrosinase CuA-binding region signature. 54 71 - T 09-03-2017 IPR002227 Tyrosinase copper-binding domain GO:0008152|GO:0016491 TK78_RS01655 d100ff53a6bb9a542bf6521d3a7561e4 287 PRINTS PR00092 Tyrosinase copper-binding domain signature 217 235 9.9E-18 T 09-03-2017 IPR002227 Tyrosinase copper-binding domain GO:0008152|GO:0016491 TK78_RS01655 d100ff53a6bb9a542bf6521d3a7561e4 287 PRINTS PR00092 Tyrosinase copper-binding domain signature 83 88 9.9E-18 T 09-03-2017 IPR002227 Tyrosinase copper-binding domain GO:0008152|GO:0016491 TK78_RS01655 d100ff53a6bb9a542bf6521d3a7561e4 287 PRINTS PR00092 Tyrosinase copper-binding domain signature 198 209 9.9E-18 T 09-03-2017 IPR002227 Tyrosinase copper-binding domain GO:0008152|GO:0016491 TK78_RS01655 d100ff53a6bb9a542bf6521d3a7561e4 287 PRINTS PR00092 Tyrosinase copper-binding domain signature 54 71 9.9E-18 T 09-03-2017 IPR002227 Tyrosinase copper-binding domain GO:0008152|GO:0016491 TK78_RS01655 d100ff53a6bb9a542bf6521d3a7561e4 287 Gene3D G3DSA:1.10.1280.10 2 286 3.4E-59 T 09-03-2017 IPR008922 Uncharacterised domain, di-copper centre TK78_RS01655 d100ff53a6bb9a542bf6521d3a7561e4 287 ProSitePatterns PS00498 Tyrosinase and hemocyanins CuB-binding region signature. 218 229 - T 09-03-2017 IPR002227 Tyrosinase copper-binding domain GO:0008152|GO:0016491 TK78_RS01655 d100ff53a6bb9a542bf6521d3a7561e4 287 SUPERFAMILY SSF48056 2 286 1.31E-59 T 09-03-2017 IPR008922 Uncharacterised domain, di-copper centre TK78_RS01655 d100ff53a6bb9a542bf6521d3a7561e4 287 Pfam PF00264 Common central domain of tyrosinase 30 237 1.9E-40 T 09-03-2017 IPR002227 Tyrosinase copper-binding domain GO:0008152|GO:0016491 TK78_RS05095 c33aa0190c8f1837c9e3ab47238994c9 280 Gene3D G3DSA:1.10.10.10 215 279 8.8E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05095 c33aa0190c8f1837c9e3ab47238994c9 280 Pfam PF00196 Bacterial regulatory proteins, luxR family 218 272 3.4E-12 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS05095 c33aa0190c8f1837c9e3ab47238994c9 280 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 219 233 2.7E-7 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS05095 c33aa0190c8f1837c9e3ab47238994c9 280 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 233 249 2.7E-7 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS05095 c33aa0190c8f1837c9e3ab47238994c9 280 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 249 261 2.7E-7 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS05095 c33aa0190c8f1837c9e3ab47238994c9 280 SMART SM00421 216 273 8.6E-16 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS05095 c33aa0190c8f1837c9e3ab47238994c9 280 Gene3D G3DSA:3.30.450.40 10 138 5.0E-8 T 09-03-2017 IPR029016 GAF domain-like TK78_RS05095 c33aa0190c8f1837c9e3ab47238994c9 280 Pfam PF01590 GAF domain 41 135 2.9E-4 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS05095 c33aa0190c8f1837c9e3ab47238994c9 280 SUPERFAMILY SSF55781 10 144 6.54E-10 T 09-03-2017 IPR029016 GAF domain-like TK78_RS05095 c33aa0190c8f1837c9e3ab47238994c9 280 SUPERFAMILY SSF46894 213 279 1.36E-16 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS17575 97ac6872d5907223a74b0936eecd1e0b 398 Gene3D G3DSA:2.40.110.10 131 234 1.3E-6 T 09-03-2017 TK78_RS17575 97ac6872d5907223a74b0936eecd1e0b 398 SUPERFAMILY SSF47203 255 391 3.06E-27 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS17575 97ac6872d5907223a74b0936eecd1e0b 398 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 6 120 8.7E-13 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS17575 97ac6872d5907223a74b0936eecd1e0b 398 SUPERFAMILY SSF56645 2 240 4.19E-27 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS17575 97ac6872d5907223a74b0936eecd1e0b 398 Gene3D G3DSA:1.20.140.10 235 383 3.3E-25 T 09-03-2017 TK78_RS17575 97ac6872d5907223a74b0936eecd1e0b 398 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 257 381 9.4E-20 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS17575 97ac6872d5907223a74b0936eecd1e0b 398 Gene3D G3DSA:1.10.540.10 2 121 4.3E-13 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS10385 e7ec5c708c2e3bdbb781bee8559da544 280 SUPERFAMILY SSF88946 89 174 5.49E-23 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS10385 e7ec5c708c2e3bdbb781bee8559da544 280 TIGRFAM TIGR02947 SigH_actino: RNA polymerase sigma-70 factor, TIGR02947 family 78 266 8.6E-108 T 09-03-2017 IPR014293 RNA polymerase sigma-70, actinobacteria GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS10385 e7ec5c708c2e3bdbb781bee8559da544 280 Pfam PF04542 Sigma-70 region 2 97 159 5.0E-17 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS10385 e7ec5c708c2e3bdbb781bee8559da544 280 SUPERFAMILY SSF88659 194 256 8.41E-16 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS10385 e7ec5c708c2e3bdbb781bee8559da544 280 Gene3D G3DSA:1.10.10.10 194 258 8.2E-24 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS10385 e7ec5c708c2e3bdbb781bee8559da544 280 Gene3D G3DSA:1.10.1740.10 84 161 1.2E-27 T 09-03-2017 TK78_RS10385 e7ec5c708c2e3bdbb781bee8559da544 280 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 96 254 1.7E-25 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS10385 e7ec5c708c2e3bdbb781bee8559da544 280 Pfam PF08281 Sigma-70, region 4 202 251 2.5E-13 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS20855 83061e38c1f5c3842757708fa553b67d 177 ProSitePatterns PS01327 Large-conductance mechanosensitive channels mscL family signature. 18 31 - T 09-03-2017 IPR019823 Large-conductance mechanosensitive channel, conserved site TK78_RS20855 83061e38c1f5c3842757708fa553b67d 177 SUPERFAMILY SSF81330 17 129 2.09E-24 T 09-03-2017 IPR001185 Large-conductance mechanosensitive channel GO:0005216|GO:0006810|GO:0016021 TK78_RS20855 83061e38c1f5c3842757708fa553b67d 177 Pfam PF01741 Large-conductance mechanosensitive channel, MscL 8 146 7.0E-34 T 09-03-2017 IPR001185 Large-conductance mechanosensitive channel GO:0005216|GO:0006810|GO:0016021 TK78_RS20855 83061e38c1f5c3842757708fa553b67d 177 TIGRFAM TIGR00220 mscL: large conductance mechanosensitive channel protein 9 147 8.9E-21 T 09-03-2017 IPR001185 Large-conductance mechanosensitive channel GO:0005216|GO:0006810|GO:0016021 TK78_RS22705 7393dd1642834aa197648d14b755c38e 100 SUPERFAMILY SSF50129 2 85 4.56E-16 T 09-03-2017 IPR011032 GroES-like TK78_RS22705 7393dd1642834aa197648d14b755c38e 100 SMART SM00883 1 85 4.7E-19 T 09-03-2017 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 TK78_RS22705 7393dd1642834aa197648d14b755c38e 100 Gene3D G3DSA:2.30.33.40 1 84 7.9E-18 T 09-03-2017 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 TK78_RS22705 7393dd1642834aa197648d14b755c38e 100 Pfam PF00166 Chaperonin 10 Kd subunit 1 84 7.5E-18 T 09-03-2017 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 TK78_RS26900 b9bd833ab4eb235cb55c0e2efa9f3603 256 Gene3D G3DSA:3.40.1130.10 18 207 1.5E-30 T 09-03-2017 TK78_RS26900 b9bd833ab4eb235cb55c0e2efa9f3603 256 Pfam PF01553 Acyltransferase 22 152 1.7E-20 T 09-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 TK78_RS26900 b9bd833ab4eb235cb55c0e2efa9f3603 256 SUPERFAMILY SSF69593 14 224 1.83E-49 T 09-03-2017 TK78_RS26900 b9bd833ab4eb235cb55c0e2efa9f3603 256 SMART SM00563 34 155 2.5E-33 T 09-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 TK78_RS02575 071c95dde4063c15532195b1a4028b39 141 Gene3D G3DSA:3.30.565.10 44 140 2.9E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS02575 071c95dde4063c15532195b1a4028b39 141 Pfam PF13581 Histidine kinase-like ATPase domain 28 138 4.1E-11 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS02575 071c95dde4063c15532195b1a4028b39 141 SUPERFAMILY SSF55874 48 139 3.56E-9 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS08245 fb2af75c978378e43161cb5062a7163e 93 Pfam PF00708 Acylphosphatase 5 93 1.1E-20 T 09-03-2017 IPR001792 Acylphosphatase-like domain KEGG: 00620+3.6.1.7|KEGG: 00627+3.6.1.7 TK78_RS08245 fb2af75c978378e43161cb5062a7163e 93 SUPERFAMILY SSF54975 4 93 7.63E-23 T 09-03-2017 IPR001792 Acylphosphatase-like domain KEGG: 00620+3.6.1.7|KEGG: 00627+3.6.1.7 TK78_RS08245 fb2af75c978378e43161cb5062a7163e 93 Gene3D G3DSA:3.30.70.100 6 93 2.6E-25 T 09-03-2017 TK78_RS15360 ff82ca98b3b696c13fde3f29bc101b92 378 Gene3D G3DSA:3.40.50.300 132 360 1.1E-21 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15360 ff82ca98b3b696c13fde3f29bc101b92 378 SUPERFAMILY SSF52540 133 351 2.45E-23 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15360 ff82ca98b3b696c13fde3f29bc101b92 378 Pfam PF01656 CobQ/CobB/MinD/ParA nucleotide binding domain 136 294 8.4E-11 T 09-03-2017 IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain TK78_RS15360 ff82ca98b3b696c13fde3f29bc101b92 378 TIGRFAM TIGR03815 CpaE_hom_Actino: helicase/secretion neighborhood CpaE-like protein 23 359 1.5E-104 T 09-03-2017 IPR022521 Conserved hypothetical protein CHP03815, CpaE-like TK78_RS29500 b1d8c047fa0c3cd90f5c2df4e89b8504 283 Pfam PF04954 Siderophore-interacting protein 138 255 4.8E-39 T 09-03-2017 IPR007037 Siderophore-interacting protein TK78_RS29500 b1d8c047fa0c3cd90f5c2df4e89b8504 283 Gene3D G3DSA:2.40.30.10 9 130 3.1E-35 T 09-03-2017 TK78_RS29500 b1d8c047fa0c3cd90f5c2df4e89b8504 283 SUPERFAMILY SSF63380 15 131 4.86E-8 T 09-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 TK78_RS29500 b1d8c047fa0c3cd90f5c2df4e89b8504 283 Gene3D G3DSA:3.40.50.80 134 276 2.1E-52 T 09-03-2017 TK78_RS29500 b1d8c047fa0c3cd90f5c2df4e89b8504 283 Pfam PF08021 Siderophore-interacting FAD-binding domain 16 130 4.3E-37 T 09-03-2017 IPR013113 FAD-binding 9, siderophore-interacting TK78_RS29585 7791b246b3498439f12bab06ce40141b 64 Pfam PF01632 Ribosomal protein L35 2 62 1.3E-25 T 09-03-2017 IPR021137 Ribosomal protein L35 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS29585 7791b246b3498439f12bab06ce40141b 64 PRINTS PR00064 Ribosomal protein L35 signature 36 54 2.6E-18 T 09-03-2017 IPR001706 Ribosomal protein L35, non-mitochondrial GO:0003735|GO:0005840|GO:0006412 TK78_RS29585 7791b246b3498439f12bab06ce40141b 64 PRINTS PR00064 Ribosomal protein L35 signature 3 20 2.6E-18 T 09-03-2017 IPR001706 Ribosomal protein L35, non-mitochondrial GO:0003735|GO:0005840|GO:0006412 TK78_RS29585 7791b246b3498439f12bab06ce40141b 64 PRINTS PR00064 Ribosomal protein L35 signature 21 35 2.6E-18 T 09-03-2017 IPR001706 Ribosomal protein L35, non-mitochondrial GO:0003735|GO:0005840|GO:0006412 TK78_RS29585 7791b246b3498439f12bab06ce40141b 64 ProSitePatterns PS00936 Ribosomal protein L35 signature. 5 31 - T 09-03-2017 IPR018265 Ribosomal protein L35, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS29585 7791b246b3498439f12bab06ce40141b 64 SUPERFAMILY SSF143034 2 63 1.96E-22 T 09-03-2017 TK78_RS29585 7791b246b3498439f12bab06ce40141b 64 Hamap MF_00514 50S ribosomal protein L35 [rpmI]. 1 64 18.741 T 09-03-2017 IPR001706 Ribosomal protein L35, non-mitochondrial GO:0003735|GO:0005840|GO:0006412 TK78_RS29585 7791b246b3498439f12bab06ce40141b 64 TIGRFAM TIGR00001 rpmI_bact: ribosomal protein bL35 2 63 1.2E-26 T 09-03-2017 IPR001706 Ribosomal protein L35, non-mitochondrial GO:0003735|GO:0005840|GO:0006412 TK78_RS22860 30044c9f37a894d98ef01327c023e91a 611 Pfam PF00176 SNF2 family N-terminal domain 170 351 2.6E-15 T 09-03-2017 IPR000330 SNF2-related, N-terminal domain GO:0005524 TK78_RS22860 30044c9f37a894d98ef01327c023e91a 611 ProSitePatterns PS00690 DEAH-box subfamily ATP-dependent helicases signature. 235 244 - T 09-03-2017 IPR002464 DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site GO:0003676|GO:0005524|GO:0008026 TK78_RS22860 30044c9f37a894d98ef01327c023e91a 611 SUPERFAMILY SSF52540 235 290 1.22E-27 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22860 30044c9f37a894d98ef01327c023e91a 611 SUPERFAMILY SSF52540 416 576 1.22E-27 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22860 30044c9f37a894d98ef01327c023e91a 611 SMART SM00487 121 299 3.1E-12 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS22860 30044c9f37a894d98ef01327c023e91a 611 SUPERFAMILY SSF52540 124 294 5.68E-27 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22860 30044c9f37a894d98ef01327c023e91a 611 Gene3D G3DSA:3.40.50.300 123 277 1.6E-13 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03550 30bf102baa4ec73af58a4a4f97ddef67 134 SMART SM00894 98 134 1.1E-19 T 09-03-2017 IPR008613 Excalibur calcium-binding domain TK78_RS03550 30bf102baa4ec73af58a4a4f97ddef67 134 Pfam PF05901 Excalibur calcium-binding domain 99 134 1.7E-13 T 09-03-2017 IPR008613 Excalibur calcium-binding domain TK78_RS04875 1de1e64c2cdb65444bf06a051ab991bf 373 Hamap MF_00813 Probable allantoicase [alc]. 24 357 51.271 T 09-03-2017 IPR005164 Allantoicase GO:0000256|GO:0004037 KEGG: 00230+3.5.3.4|MetaCyc: PWY-5697 TK78_RS04875 1de1e64c2cdb65444bf06a051ab991bf 373 Gene3D G3DSA:2.60.120.260 215 357 1.5E-42 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS04875 1de1e64c2cdb65444bf06a051ab991bf 373 Gene3D G3DSA:2.60.120.260 27 207 4.5E-58 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS04875 1de1e64c2cdb65444bf06a051ab991bf 373 SUPERFAMILY SSF49785 26 207 2.13E-54 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS04875 1de1e64c2cdb65444bf06a051ab991bf 373 SUPERFAMILY SSF49785 213 357 8.93E-44 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS04875 1de1e64c2cdb65444bf06a051ab991bf 373 PIRSF PIRSF016516 20 358 8.4E-97 T 09-03-2017 IPR005164 Allantoicase GO:0000256|GO:0004037 KEGG: 00230+3.5.3.4|MetaCyc: PWY-5697 TK78_RS04875 1de1e64c2cdb65444bf06a051ab991bf 373 TIGRFAM TIGR02961 allantoicase: allantoicase 35 354 1.6E-124 T 09-03-2017 IPR005164 Allantoicase GO:0000256|GO:0004037 KEGG: 00230+3.5.3.4|MetaCyc: PWY-5697 TK78_RS04875 1de1e64c2cdb65444bf06a051ab991bf 373 Pfam PF03561 Allantoicase repeat 226 354 6.2E-36 T 09-03-2017 IPR015908 Allantoicase domain GO:0000256|GO:0004037 KEGG: 00230+3.5.3.4|MetaCyc: PWY-5697 TK78_RS04875 1de1e64c2cdb65444bf06a051ab991bf 373 Pfam PF03561 Allantoicase repeat 44 203 9.2E-45 T 09-03-2017 IPR015908 Allantoicase domain GO:0000256|GO:0004037 KEGG: 00230+3.5.3.4|MetaCyc: PWY-5697 TK78_RS26615 2a5dcfe427571002b1273fd1201fe7ec 327 Pfam PF13280 WYL domain 139 322 2.0E-41 T 09-03-2017 IPR026881 WYL domain TK78_RS26615 2a5dcfe427571002b1273fd1201fe7ec 327 SUPERFAMILY SSF46785 3 59 3.29E-9 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS26615 2a5dcfe427571002b1273fd1201fe7ec 327 Gene3D G3DSA:1.10.10.10 3 63 1.7E-14 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS26615 2a5dcfe427571002b1273fd1201fe7ec 327 Pfam PF08279 HTH domain 5 60 2.3E-15 T 09-03-2017 IPR013196 Helix-turn-helix, type 11 TK78_RS01465 41cb198d26ab7b991abe4ec9e6951430 300 SUPERFAMILY SSF56601 184 273 3.68E-30 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS01465 41cb198d26ab7b991abe4ec9e6951430 300 SUPERFAMILY SSF56601 5 152 3.68E-30 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS01465 41cb198d26ab7b991abe4ec9e6951430 300 Pfam PF13354 Beta-lactamase enzyme family 28 268 2.7E-41 T 09-03-2017 TK78_RS01465 41cb198d26ab7b991abe4ec9e6951430 300 Gene3D G3DSA:3.40.710.10 184 299 1.4E-42 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS01465 41cb198d26ab7b991abe4ec9e6951430 300 Gene3D G3DSA:3.40.710.10 18 151 1.4E-42 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS32750 e7f0d00212d4394be79b7f65612c493a 309 Pfam PF00480 ROK family 7 305 8.5E-60 T 09-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 TK78_RS32750 e7f0d00212d4394be79b7f65612c493a 309 SUPERFAMILY SSF53067 6 307 3.75E-58 T 09-03-2017 TK78_RS32750 e7f0d00212d4394be79b7f65612c493a 309 Gene3D G3DSA:3.30.420.40 141 290 3.9E-45 T 09-03-2017 TK78_RS32750 e7f0d00212d4394be79b7f65612c493a 309 Gene3D G3DSA:3.30.420.40 5 140 1.3E-35 T 09-03-2017 TK78_RS32750 e7f0d00212d4394be79b7f65612c493a 309 ProSitePatterns PS01125 ROK family signature. 138 165 - T 09-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 TK78_RS31150 201314adeb551057dcfc1e56d78b3be1 229 Hamap MF_01633 7-cyano-7-deazaguanine synthase [queC]. 8 224 40.522 T 09-03-2017 IPR018317 Queuosine biosynthesis protein QueC KEGG: 00790+6.3.4.20|MetaCyc: PWY-6703 TK78_RS31150 201314adeb551057dcfc1e56d78b3be1 229 Gene3D G3DSA:3.40.50.620 9 229 1.4E-59 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS31150 201314adeb551057dcfc1e56d78b3be1 229 TIGRFAM TIGR00364 TIGR00364: queuosine biosynthesis protein QueC 11 211 1.4E-47 T 09-03-2017 IPR018317 Queuosine biosynthesis protein QueC KEGG: 00790+6.3.4.20|MetaCyc: PWY-6703 TK78_RS31150 201314adeb551057dcfc1e56d78b3be1 229 PIRSF PIRSF006293 6 229 2.2E-64 T 09-03-2017 IPR018317 Queuosine biosynthesis protein QueC KEGG: 00790+6.3.4.20|MetaCyc: PWY-6703 TK78_RS31150 201314adeb551057dcfc1e56d78b3be1 229 SUPERFAMILY SSF52402 9 228 3.75E-53 T 09-03-2017 TK78_RS31150 201314adeb551057dcfc1e56d78b3be1 229 Pfam PF06508 Queuosine biosynthesis protein QueC 10 218 9.4E-55 T 09-03-2017 IPR018317 Queuosine biosynthesis protein QueC KEGG: 00790+6.3.4.20|MetaCyc: PWY-6703 TK78_RS21495 5cd31130726a6282cec54f58423e3ca0 102 SMART SM00418 9 100 5.2E-14 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS21495 5cd31130726a6282cec54f58423e3ca0 102 SUPERFAMILY SSF46785 6 100 2.94E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS21495 5cd31130726a6282cec54f58423e3ca0 102 Gene3D G3DSA:1.10.10.10 5 100 7.8E-30 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS21495 5cd31130726a6282cec54f58423e3ca0 102 Pfam PF12840 Helix-turn-helix domain 9 79 3.3E-9 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS29590 3c3e7340ee3b59a9ae11b554733b6d34 127 SUPERFAMILY SSF74731 3 117 1.83E-45 T 09-03-2017 TK78_RS29590 3c3e7340ee3b59a9ae11b554733b6d34 127 ProDom PD002389 RIBOSOMAL RRNA-BINDING RNA-BINDING RIBONUCLEOPROTEIN L20 50S L20 CHLOROPLAST BACTERIAL ORGANELLE 21 72 3.0E-24 T 09-03-2017 TK78_RS29590 3c3e7340ee3b59a9ae11b554733b6d34 127 Hamap MF_00382 50S ribosomal protein L20 [rplT]. 2 115 27.735 T 09-03-2017 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS29590 3c3e7340ee3b59a9ae11b554733b6d34 127 ProSitePatterns PS00937 Ribosomal protein L20 signature. 54 70 - T 09-03-2017 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS29590 3c3e7340ee3b59a9ae11b554733b6d34 127 PRINTS PR00062 Ribosomal protein L20 signature 12 41 1.0E-37 T 09-03-2017 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS29590 3c3e7340ee3b59a9ae11b554733b6d34 127 PRINTS PR00062 Ribosomal protein L20 signature 42 71 1.0E-37 T 09-03-2017 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS29590 3c3e7340ee3b59a9ae11b554733b6d34 127 PRINTS PR00062 Ribosomal protein L20 signature 75 101 1.0E-37 T 09-03-2017 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS29590 3c3e7340ee3b59a9ae11b554733b6d34 127 Pfam PF00453 Ribosomal protein L20 3 109 2.7E-44 T 09-03-2017 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS29590 3c3e7340ee3b59a9ae11b554733b6d34 127 Gene3D G3DSA:1.10.1900.20 56 117 4.7E-32 T 09-03-2017 TK78_RS29590 3c3e7340ee3b59a9ae11b554733b6d34 127 TIGRFAM TIGR01032 rplT_bact: ribosomal protein bL20 2 113 2.6E-44 T 09-03-2017 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS27480 cdb12469bd36cea2f5b83d6814e26263 249 SMART SM00882 13 208 4.4E-4 T 09-03-2017 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 TK78_RS27480 cdb12469bd36cea2f5b83d6814e26263 249 SUPERFAMILY SSF100950 9 244 2.01E-51 T 09-03-2017 TK78_RS27480 cdb12469bd36cea2f5b83d6814e26263 249 Pfam PF01144 Coenzyme A transferase 89 207 6.8E-9 T 09-03-2017 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 TK78_RS27480 cdb12469bd36cea2f5b83d6814e26263 249 Gene3D G3DSA:3.40.810.20 9 246 2.6E-65 T 09-03-2017 TK78_RS01810 73f3bb2e017b343521cc9add7a8a1b44 505 Pfam PF00005 ABC transporter 28 178 7.7E-30 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS01810 73f3bb2e017b343521cc9add7a8a1b44 505 Pfam PF00005 ABC transporter 278 431 8.0E-19 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS01810 73f3bb2e017b343521cc9add7a8a1b44 505 Gene3D G3DSA:3.40.50.300 10 244 6.4E-62 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01810 73f3bb2e017b343521cc9add7a8a1b44 505 SUPERFAMILY SSF52540 11 237 1.49E-59 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01810 73f3bb2e017b343521cc9add7a8a1b44 505 SMART SM00382 37 225 3.2E-11 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS01810 73f3bb2e017b343521cc9add7a8a1b44 505 SMART SM00382 286 480 0.0039 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS01810 73f3bb2e017b343521cc9add7a8a1b44 505 ProSitePatterns PS00211 ABC transporters family signature. 404 418 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS01810 73f3bb2e017b343521cc9add7a8a1b44 505 SUPERFAMILY SSF52540 274 489 2.8E-43 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01810 73f3bb2e017b343521cc9add7a8a1b44 505 Gene3D G3DSA:3.40.50.300 261 494 1.4E-46 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS12815 308cbbce66eba526ab062461668f99cc 154 SUPERFAMILY SSF54593 3 154 4.17E-49 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS12815 308cbbce66eba526ab062461668f99cc 154 Gene3D G3DSA:3.10.180.10 1 129 3.9E-47 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS12815 308cbbce66eba526ab062461668f99cc 154 Pfam PF06983 3-demethylubiquinone-9 3-methyltransferase 2 117 2.8E-46 T 09-03-2017 IPR028973 PhnB-like TK78_RS12815 308cbbce66eba526ab062461668f99cc 154 PIRSF PIRSF021700 1 154 6.9E-60 T 09-03-2017 IPR009725 Predicted 3-demethylubiquinone-9 3-methyltransferase TK78_RS21020 95eb575ec91a082cafcb13f2301c08b8 379 Pfam PF00355 Rieske [2Fe-2S] domain 37 117 9.3E-17 T 09-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 TK78_RS21020 95eb575ec91a082cafcb13f2301c08b8 379 SUPERFAMILY SSF55961 135 347 4.94E-25 T 09-03-2017 TK78_RS21020 95eb575ec91a082cafcb13f2301c08b8 379 SUPERFAMILY SSF50022 34 146 2.23E-31 T 09-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 TK78_RS21020 95eb575ec91a082cafcb13f2301c08b8 379 Gene3D G3DSA:2.102.10.10 35 148 1.0E-30 T 09-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 TK78_RS08560 9a791c48e8e4129d1949d62d9533e346 201 Gene3D G3DSA:3.40.430.10 5 188 2.5E-18 T 09-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 TK78_RS08560 9a791c48e8e4129d1949d62d9533e346 201 Pfam PF01872 RibD C-terminal domain 5 183 9.8E-23 T 09-03-2017 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 TK78_RS08560 9a791c48e8e4129d1949d62d9533e346 201 SUPERFAMILY SSF53597 6 192 2.13E-22 T 09-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 TK78_RS09730 5af85110ef69cd14484e442e8472157a 281 ProSitePatterns PS00092 N-6 Adenine-specific DNA methylases signature. 181 187 - T 09-03-2017 IPR002052 DNA methylase, N-6 adenine-specific, conserved site GO:0003676|GO:0008168|GO:0032259 TK78_RS09730 5af85110ef69cd14484e442e8472157a 281 Gene3D G3DSA:1.10.8.10 8 83 9.4E-18 T 09-03-2017 TK78_RS09730 5af85110ef69cd14484e442e8472157a 281 Hamap MF_02126 Release factor glutamine methyltransferase [prmC]. 4 278 41.968 T 09-03-2017 IPR019874 Protein-(glutamine-N5) methyltransferase, release factor-specific GO:0008168 TK78_RS09730 5af85110ef69cd14484e442e8472157a 281 TIGRFAM TIGR00536 hemK_fam: methyltransferase, HemK family 53 278 5.8E-50 T 09-03-2017 IPR004556 Modification methylase HemK GO:0006479|GO:0008276 TK78_RS09730 5af85110ef69cd14484e442e8472157a 281 Gene3D G3DSA:3.40.50.150 85 278 7.4E-58 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS09730 5af85110ef69cd14484e442e8472157a 281 Pfam PF05175 Methyltransferase small domain 113 187 3.1E-13 T 09-03-2017 IPR007848 Methyltransferase small domain GO:0008168 TK78_RS09730 5af85110ef69cd14484e442e8472157a 281 SUPERFAMILY SSF53335 17 251 1.01E-48 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS09730 5af85110ef69cd14484e442e8472157a 281 TIGRFAM TIGR03534 RF_mod_PrmC: protein-(glutamine-N5) methyltransferase, release factor-specific 26 274 1.2E-72 T 09-03-2017 IPR019874 Protein-(glutamine-N5) methyltransferase, release factor-specific GO:0008168 TK78_RS21115 6585594ff0c9fefd1403d65f958dc5e1 249 SUPERFAMILY SSF46689 201 245 9.86E-9 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS21115 6585594ff0c9fefd1403d65f958dc5e1 249 Gene3D G3DSA:1.10.10.60 144 202 2.6E-13 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS21115 6585594ff0c9fefd1403d65f958dc5e1 249 Pfam PF07883 Cupin domain 16 78 2.6E-7 T 09-03-2017 IPR013096 Cupin 2, conserved barrel TK78_RS21115 6585594ff0c9fefd1403d65f958dc5e1 249 Pfam PF12833 Helix-turn-helix domain 173 244 1.4E-21 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS21115 6585594ff0c9fefd1403d65f958dc5e1 249 SUPERFAMILY SSF51182 13 170 4.55E-20 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS21115 6585594ff0c9fefd1403d65f958dc5e1 249 SMART SM00342 165 247 2.7E-24 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS21115 6585594ff0c9fefd1403d65f958dc5e1 249 Gene3D G3DSA:1.10.10.60 203 245 1.4E-10 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS21115 6585594ff0c9fefd1403d65f958dc5e1 249 Gene3D G3DSA:2.60.120.10 16 78 2.8E-11 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS29255 737be741169b90cf2583b2f6bac96605 1021 SUPERFAMILY SSF51011 521 602 1.08E-17 T 09-03-2017 TK78_RS29255 737be741169b90cf2583b2f6bac96605 1021 SUPERFAMILY SSF74650 37 246 1.82E-29 T 09-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 TK78_RS29255 737be741169b90cf2583b2f6bac96605 1021 Pfam PF16338 Domain of unknown function (DUF4968) 53 143 2.3E-14 T 09-03-2017 IPR032513 Alpha-glucosidase, domain of unknown function DUF4968 TK78_RS29255 737be741169b90cf2583b2f6bac96605 1021 Pfam PF17137 Domain of unknown function (DUF5110) 624 697 2.1E-17 T 09-03-2017 IPR033403 Domain of unknown function DUF5110 TK78_RS29255 737be741169b90cf2583b2f6bac96605 1021 SMART SM00776 875 1020 1.9E-50 T 09-03-2017 IPR013222 Glycosyl hydrolase family 98, putative carbohydrate-binding module TK78_RS29255 737be741169b90cf2583b2f6bac96605 1021 SUPERFAMILY SSF49785 878 1020 8.5E-41 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS29255 737be741169b90cf2583b2f6bac96605 1021 Pfam PF08305 NPCBM/NEW2 domain 878 1018 7.9E-46 T 09-03-2017 IPR013222 Glycosyl hydrolase family 98, putative carbohydrate-binding module TK78_RS29255 737be741169b90cf2583b2f6bac96605 1021 Pfam PF01055 Glycosyl hydrolases family 31 379 606 8.5E-52 T 09-03-2017 IPR000322 Glycoside hydrolase family 31 GO:0004553|GO:0005975 TK78_RS29255 737be741169b90cf2583b2f6bac96605 1021 Pfam PF10633 NPCBM-associated, NEW3 domain of alpha-galactosidase 781 853 2.2E-7 T 09-03-2017 IPR018905 Alpha-galactosidase, NEW3 domain TK78_RS29255 737be741169b90cf2583b2f6bac96605 1021 SUPERFAMILY SSF51445 252 518 1.05E-25 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS29255 737be741169b90cf2583b2f6bac96605 1021 Gene3D G3DSA:2.60.40.10 777 863 1.1E-5 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS13440 855a8e5688a1ee6506d9e8a2d7682fd0 219 Gene3D G3DSA:1.10.10.10 154 218 3.3E-24 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS13440 855a8e5688a1ee6506d9e8a2d7682fd0 219 Pfam PF00196 Bacterial regulatory proteins, luxR family 156 200 3.5E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS13440 855a8e5688a1ee6506d9e8a2d7682fd0 219 Pfam PF00072 Response regulator receiver domain 3 113 1.7E-13 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS13440 855a8e5688a1ee6506d9e8a2d7682fd0 219 SUPERFAMILY SSF52172 2 175 3.83E-15 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS13440 855a8e5688a1ee6506d9e8a2d7682fd0 219 SMART SM00448 1 125 7.6E-10 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS13440 855a8e5688a1ee6506d9e8a2d7682fd0 219 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 156 170 2.1E-10 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS13440 855a8e5688a1ee6506d9e8a2d7682fd0 219 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 170 186 2.1E-10 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS13440 855a8e5688a1ee6506d9e8a2d7682fd0 219 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 186 198 2.1E-10 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS13440 855a8e5688a1ee6506d9e8a2d7682fd0 219 Gene3D G3DSA:3.40.50.2300 2 153 1.2E-23 T 09-03-2017 TK78_RS13440 855a8e5688a1ee6506d9e8a2d7682fd0 219 SMART SM00421 153 215 7.3E-14 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS02640 8b1ea2cb37310ac01958a5b96312d91b 403 Gene3D G3DSA:3.40.640.10 33 263 1.0E-55 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS02640 8b1ea2cb37310ac01958a5b96312d91b 403 Pfam PF00266 Aminotransferase class-V 22 394 3.6E-56 T 09-03-2017 IPR000192 Aminotransferase class V domain TK78_RS02640 8b1ea2cb37310ac01958a5b96312d91b 403 SUPERFAMILY SSF53383 3 402 5.98E-86 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS02640 8b1ea2cb37310ac01958a5b96312d91b 403 TIGRFAM TIGR01976 am_tr_V_VC1184: cysteine desulfurase family protein 3 397 2.0E-139 T 09-03-2017 IPR011340 Cysteine desulfurase-related TK78_RS02640 8b1ea2cb37310ac01958a5b96312d91b 403 Gene3D G3DSA:3.90.1150.10 264 401 2.5E-23 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS06220 98672e423dc846ec1900c8d2fbc2c1fc 405 Pfam PF01494 FAD binding domain 114 356 2.2E-9 T 09-03-2017 IPR002938 FAD-binding domain GO:0071949 TK78_RS06220 98672e423dc846ec1900c8d2fbc2c1fc 405 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 295 310 1.4E-14 T 09-03-2017 TK78_RS06220 98672e423dc846ec1900c8d2fbc2c1fc 405 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 146 161 1.4E-14 T 09-03-2017 TK78_RS06220 98672e423dc846ec1900c8d2fbc2c1fc 405 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 5 27 1.4E-14 T 09-03-2017 TK78_RS06220 98672e423dc846ec1900c8d2fbc2c1fc 405 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 310 326 1.4E-14 T 09-03-2017 TK78_RS06220 98672e423dc846ec1900c8d2fbc2c1fc 405 SUPERFAMILY SSF54373 171 288 1.37E-25 T 09-03-2017 TK78_RS06220 98672e423dc846ec1900c8d2fbc2c1fc 405 SUPERFAMILY SSF51905 6 167 9.27E-45 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS06220 98672e423dc846ec1900c8d2fbc2c1fc 405 SUPERFAMILY SSF51905 282 381 9.27E-45 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS06220 98672e423dc846ec1900c8d2fbc2c1fc 405 Gene3D G3DSA:3.50.50.60 6 172 9.6E-33 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS06220 98672e423dc846ec1900c8d2fbc2c1fc 405 Gene3D G3DSA:3.50.50.60 283 362 9.6E-33 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS27080 fcee8908d99b492d4da3c406dfba7212 473 Pfam PF01225 Mur ligase family, catalytic domain 31 91 3.9E-11 T 09-03-2017 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 TK78_RS27080 fcee8908d99b492d4da3c406dfba7212 473 Pfam PF08245 Mur ligase middle domain 108 294 1.5E-48 T 09-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 TK78_RS27080 fcee8908d99b492d4da3c406dfba7212 473 SUPERFAMILY SSF63418 3 97 3.14E-21 T 09-03-2017 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 TK78_RS27080 fcee8908d99b492d4da3c406dfba7212 473 TIGRFAM TIGR01143 murF: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase 33 461 2.9E-132 T 09-03-2017 IPR005863 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase GO:0005524|GO:0005737|GO:0047480|GO:0071555 KEGG: 00300+6.3.2.10|KEGG: 00550+6.3.2.10|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS27080 fcee8908d99b492d4da3c406dfba7212 473 Gene3D G3DSA:3.40.1390.10 3 81 1.5E-22 T 09-03-2017 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 TK78_RS27080 fcee8908d99b492d4da3c406dfba7212 473 SUPERFAMILY SSF53244 317 461 7.88E-35 T 09-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TK78_RS27080 fcee8908d99b492d4da3c406dfba7212 473 SUPERFAMILY SSF53623 103 310 8.5E-57 T 09-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 TK78_RS27080 fcee8908d99b492d4da3c406dfba7212 473 Gene3D G3DSA:3.40.1190.10 84 310 1.4E-72 T 09-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 TK78_RS27080 fcee8908d99b492d4da3c406dfba7212 473 Gene3D G3DSA:3.90.190.20 316 464 1.8E-42 T 09-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TK78_RS27080 fcee8908d99b492d4da3c406dfba7212 473 Hamap MF_02019 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [murF]. 4 462 33.028 T 09-03-2017 IPR005863 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase GO:0005524|GO:0005737|GO:0047480|GO:0071555 KEGG: 00300+6.3.2.10|KEGG: 00550+6.3.2.10|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS27080 fcee8908d99b492d4da3c406dfba7212 473 Pfam PF02875 Mur ligase family, glutamate ligase domain 318 403 8.7E-20 T 09-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TK78_RS34055 4d192bf05d292b40e16785eab016338c 725 Pfam PF00069 Protein kinase domain 11 226 9.2E-50 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS34055 4d192bf05d292b40e16785eab016338c 725 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 17 40 - T 09-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 TK78_RS34055 4d192bf05d292b40e16785eab016338c 725 SUPERFAMILY SSF48452 376 486 1.18E-14 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS34055 4d192bf05d292b40e16785eab016338c 725 Gene3D G3DSA:1.10.510.10 82 269 1.2E-49 T 09-03-2017 TK78_RS34055 4d192bf05d292b40e16785eab016338c 725 Gene3D G3DSA:1.25.40.10 379 696 5.3E-33 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS34055 4d192bf05d292b40e16785eab016338c 725 SMART SM00220 11 279 8.2E-64 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS34055 4d192bf05d292b40e16785eab016338c 725 Gene3D G3DSA:3.30.200.20 5 81 1.8E-23 T 09-03-2017 TK78_RS34055 4d192bf05d292b40e16785eab016338c 725 Pfam PF13424 Tetratricopeptide repeat 540 608 1.5E-9 T 09-03-2017 TK78_RS34055 4d192bf05d292b40e16785eab016338c 725 Pfam PF13424 Tetratricopeptide repeat 463 527 4.7E-13 T 09-03-2017 TK78_RS34055 4d192bf05d292b40e16785eab016338c 725 Pfam PF13424 Tetratricopeptide repeat 381 445 4.1E-10 T 09-03-2017 TK78_RS34055 4d192bf05d292b40e16785eab016338c 725 Pfam PF13374 Tetratricopeptide repeat 624 665 7.1E-10 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS34055 4d192bf05d292b40e16785eab016338c 725 Pfam PF13374 Tetratricopeptide repeat 672 706 1.9E-5 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS34055 4d192bf05d292b40e16785eab016338c 725 SUPERFAMILY SSF56112 5 277 2.02E-76 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS34055 4d192bf05d292b40e16785eab016338c 725 SUPERFAMILY SSF48452 577 724 1.28E-18 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS34055 4d192bf05d292b40e16785eab016338c 725 SUPERFAMILY SSF48452 451 569 6.45E-18 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS20185 f11080a86253e25a4fbf96df223385b3 235 Pfam PF13304 AAA domain, putative AbiEii toxin, Type IV TA system 140 190 2.1E-6 T 09-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 TK78_RS20185 f11080a86253e25a4fbf96df223385b3 235 SUPERFAMILY SSF52540 33 205 1.53E-18 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS20185 f11080a86253e25a4fbf96df223385b3 235 Gene3D G3DSA:3.40.50.300 26 72 5.0E-8 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS20185 f11080a86253e25a4fbf96df223385b3 235 SMART SM00382 36 204 5.8E-9 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS20185 f11080a86253e25a4fbf96df223385b3 235 Pfam PF13476 AAA domain 24 58 2.2E-6 T 09-03-2017 TK78_RS20185 f11080a86253e25a4fbf96df223385b3 235 Gene3D G3DSA:3.40.50.300 130 204 1.6E-9 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17965 a5a2a7775fbf2f3916f94251968a0942 185 Gene3D G3DSA:3.40.50.1950 9 164 2.1E-21 T 09-03-2017 IPR003382 Flavoprotein GO:0003824 Reactome: R-HSA-196783 TK78_RS17965 a5a2a7775fbf2f3916f94251968a0942 185 SUPERFAMILY SSF52507 11 161 7.98E-26 T 09-03-2017 IPR003382 Flavoprotein GO:0003824 Reactome: R-HSA-196783 TK78_RS17965 a5a2a7775fbf2f3916f94251968a0942 185 Pfam PF02441 Flavoprotein 16 136 1.2E-9 T 09-03-2017 IPR003382 Flavoprotein GO:0003824 Reactome: R-HSA-196783 TK78_RS05750 5fec168bca03271a14bef12ffc4dbfcb 279 Gene3D G3DSA:3.40.50.1820 4 277 3.1E-39 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS05750 5fec168bca03271a14bef12ffc4dbfcb 279 Pfam PF12697 Alpha/beta hydrolase family 23 269 3.0E-15 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS05750 5fec168bca03271a14bef12ffc4dbfcb 279 SUPERFAMILY SSF53474 6 277 9.05E-40 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS12995 f2cf290aea090ff1d5c88d63431818cd 175 Pfam PF00380 Ribosomal protein S9/S16 54 175 2.2E-43 T 09-03-2017 IPR000754 Ribosomal protein S9 GO:0003735|GO:0005840|GO:0006412 TK78_RS12995 f2cf290aea090ff1d5c88d63431818cd 175 SUPERFAMILY SSF54211 51 175 3.72E-42 T 09-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold TK78_RS12995 f2cf290aea090ff1d5c88d63431818cd 175 ProSitePatterns PS00360 Ribosomal protein S9 signature. 113 131 - T 09-03-2017 IPR020574 Ribosomal protein S9, conserved site GO:0003735|GO:0005840|GO:0006412 TK78_RS12995 f2cf290aea090ff1d5c88d63431818cd 175 Hamap MF_00532_B 30S ribosomal protein S9 [rpsI]. 45 175 32.957 T 09-03-2017 IPR023035 Ribosomal protein S9, bacterial/plastid TK78_RS12995 f2cf290aea090ff1d5c88d63431818cd 175 Gene3D G3DSA:3.30.230.10 51 175 2.4E-47 T 09-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TK78_RS06625 c2f71784cbebacad53ccafc0e451c7d9 96 Gene3D G3DSA:3.10.20.30 16 89 2.4E-5 T 09-03-2017 IPR012675 Beta-grasp domain TK78_RS06625 c2f71784cbebacad53ccafc0e451c7d9 96 Pfam PF13510 2Fe-2S iron-sulfur cluster binding domain 15 91 3.3E-23 T 09-03-2017 TK78_RS06625 c2f71784cbebacad53ccafc0e451c7d9 96 SUPERFAMILY SSF54292 16 93 4.72E-18 T 09-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 TK78_RS32170 4af6155dddf233988482f55c00d83703 281 ProSitePatterns PS00221 MIP family signature. 76 84 - T 09-03-2017 IPR022357 Major intrinsic protein, conserved site GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS32170 4af6155dddf233988482f55c00d83703 281 Gene3D G3DSA:1.20.1080.10 6 270 5.5E-80 T 09-03-2017 IPR023271 Aquaporin-like Reactome: R-HSA-432047 TK78_RS32170 4af6155dddf233988482f55c00d83703 281 PRINTS PR00783 Major intrinsic protein family signature 95 114 2.2E-46 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS32170 4af6155dddf233988482f55c00d83703 281 PRINTS PR00783 Major intrinsic protein family signature 58 82 2.2E-46 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS32170 4af6155dddf233988482f55c00d83703 281 PRINTS PR00783 Major intrinsic protein family signature 240 260 2.2E-46 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS32170 4af6155dddf233988482f55c00d83703 281 PRINTS PR00783 Major intrinsic protein family signature 12 31 2.2E-46 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS32170 4af6155dddf233988482f55c00d83703 281 PRINTS PR00783 Major intrinsic protein family signature 191 213 2.2E-46 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS32170 4af6155dddf233988482f55c00d83703 281 PRINTS PR00783 Major intrinsic protein family signature 158 176 2.2E-46 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS32170 4af6155dddf233988482f55c00d83703 281 SUPERFAMILY SSF81338 11 261 1.83E-66 T 09-03-2017 IPR023271 Aquaporin-like Reactome: R-HSA-432047 TK78_RS32170 4af6155dddf233988482f55c00d83703 281 Pfam PF00230 Major intrinsic protein 8 257 2.3E-51 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS32170 4af6155dddf233988482f55c00d83703 281 TIGRFAM TIGR00861 MIP: MIP family channel proteins 16 257 9.3E-64 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS26825 7de51ee2ce16463ac537c9bd8a8292e2 453 Pfam PF05991 YacP-like NYN domain 332 451 6.2E-16 T 09-03-2017 IPR010298 Protein of unknown function DUF901 TK78_RS10815 56c56ea302271da6e49673adf1bb1664 290 TIGRFAM TIGR01496 DHPS: dihydropteroate synthase 20 275 4.9E-81 T 09-03-2017 IPR006390 Dihydropteroate synthase GO:0004156|GO:0009396 KEGG: 00790+2.5.1.15|MetaCyc: PWY-6614 TK78_RS10815 56c56ea302271da6e49673adf1bb1664 290 ProSitePatterns PS00792 Dihydropteroate synthase signature 1. 20 35 - T 09-03-2017 IPR000489 Pterin-binding domain GO:0042558 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TK78_RS10815 56c56ea302271da6e49673adf1bb1664 290 Gene3D G3DSA:3.20.20.20 16 278 4.2E-84 T 09-03-2017 IPR000489 Pterin-binding domain GO:0042558 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TK78_RS10815 56c56ea302271da6e49673adf1bb1664 290 ProSitePatterns PS00793 Dihydropteroate synthase signature 2. 54 67 - T 09-03-2017 IPR000489 Pterin-binding domain GO:0042558 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TK78_RS10815 56c56ea302271da6e49673adf1bb1664 290 SUPERFAMILY SSF51717 9 279 2.62E-81 T 09-03-2017 IPR011005 Dihydropteroate synthase-like GO:0044237 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TK78_RS10815 56c56ea302271da6e49673adf1bb1664 290 Pfam PF00809 Pterin binding enzyme 21 261 3.5E-64 T 09-03-2017 IPR000489 Pterin-binding domain GO:0042558 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TK78_RS03995 2a784dc795c99c613b80cfd52056b03d 278 ProSitePatterns PS00063 Aldo/keto reductase family putative active site signature. 230 245 - T 09-03-2017 IPR018170 Aldo/keto reductase, conserved site GO:0016491|GO:0055114 TK78_RS03995 2a784dc795c99c613b80cfd52056b03d 278 PIRSF PIRSF000097 2 271 1.5E-89 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS03995 2a784dc795c99c613b80cfd52056b03d 278 Pfam PF00248 Aldo/keto reductase family 18 262 4.9E-51 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS03995 2a784dc795c99c613b80cfd52056b03d 278 PRINTS PR00069 Aldo-keto reductase signature 159 188 2.9E-47 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS03995 2a784dc795c99c613b80cfd52056b03d 278 PRINTS PR00069 Aldo-keto reductase signature 37 61 2.9E-47 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS03995 2a784dc795c99c613b80cfd52056b03d 278 PRINTS PR00069 Aldo-keto reductase signature 93 111 2.9E-47 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS03995 2a784dc795c99c613b80cfd52056b03d 278 PRINTS PR00069 Aldo-keto reductase signature 125 142 2.9E-47 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS03995 2a784dc795c99c613b80cfd52056b03d 278 PRINTS PR00069 Aldo-keto reductase signature 197 221 2.9E-47 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS03995 2a784dc795c99c613b80cfd52056b03d 278 ProSitePatterns PS00062 Aldo/keto reductase family signature 2. 125 142 - T 09-03-2017 IPR018170 Aldo/keto reductase, conserved site GO:0016491|GO:0055114 TK78_RS03995 2a784dc795c99c613b80cfd52056b03d 278 Gene3D G3DSA:3.20.20.100 6 272 9.8E-106 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS03995 2a784dc795c99c613b80cfd52056b03d 278 SUPERFAMILY SSF51430 7 267 5.37E-94 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS07545 d2873702eb47619823518f9190712171 289 SUPERFAMILY SSF81624 2 125 1.1E-26 T 09-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 TK78_RS07545 d2873702eb47619823518f9190712171 289 SMART SM00898 2 110 1.5E-20 T 09-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 TK78_RS07545 d2873702eb47619823518f9190712171 289 SUPERFAMILY SSF57716 241 284 2.51E-12 T 09-03-2017 TK78_RS07545 d2873702eb47619823518f9190712171 289 Pfam PF01149 Formamidopyrimidine-DNA glycosylase N-terminal domain 1 78 3.0E-9 T 09-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 TK78_RS07545 d2873702eb47619823518f9190712171 289 ProSitePatterns PS01242 Zinc finger FPG-type signature. 260 284 - T 09-03-2017 IPR015887 DNA glycosylase/AP lyase, zinc finger domain, DNA-binding site GO:0003677|GO:0003906|GO:0006281|GO:0008270|GO:0016799 TK78_RS07545 d2873702eb47619823518f9190712171 289 Gene3D G3DSA:3.20.190.10 2 117 1.9E-16 T 09-03-2017 TK78_RS07545 d2873702eb47619823518f9190712171 289 Pfam PF06827 Zinc finger found in FPG and IleRS 259 285 8.5E-7 T 09-03-2017 IPR010663 Zinc finger, FPG/IleRS-type Reactome: R-HSA-379726 TK78_RS07545 d2873702eb47619823518f9190712171 289 Pfam PF06831 Formamidopyrimidine-DNA glycosylase H2TH domain 124 180 5.0E-9 T 09-03-2017 IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding GO:0003684|GO:0003906|GO:0006289|GO:0008270|GO:0016799 TK78_RS07545 d2873702eb47619823518f9190712171 289 Gene3D G3DSA:1.10.8.50 124 285 5.8E-38 T 09-03-2017 TK78_RS07545 d2873702eb47619823518f9190712171 289 SMART SM01232 124 214 1.9E-23 T 09-03-2017 IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding GO:0003684|GO:0003906|GO:0006289|GO:0008270|GO:0016799 TK78_RS07545 d2873702eb47619823518f9190712171 289 SUPERFAMILY SSF46946 123 197 7.2E-19 T 09-03-2017 IPR010979 Ribosomal protein S13-like, H2TH GO:0003676 TK78_RS26685 a0884cd7a115f3001f4c2da52ca9cb8f 235 SUPERFAMILY SSF53335 8 167 4.97E-31 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS26685 a0884cd7a115f3001f4c2da52ca9cb8f 235 Pfam PF08241 Methyltransferase domain 23 123 2.6E-18 T 09-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 TK78_RS26685 a0884cd7a115f3001f4c2da52ca9cb8f 235 Gene3D G3DSA:3.40.50.150 10 141 5.4E-29 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS01980 afb8c61d39f48a7476d3fb8e4fb38358 314 SUPERFAMILY SSF53328 1 202 2.22E-55 T 09-03-2017 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 TK78_RS01980 afb8c61d39f48a7476d3fb8e4fb38358 314 Gene3D G3DSA:3.10.25.10 205 305 7.2E-20 T 09-03-2017 IPR005793 Formyl transferase, C-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 TK78_RS01980 afb8c61d39f48a7476d3fb8e4fb38358 314 Gene3D G3DSA:3.40.50.170 1 202 6.6E-53 T 09-03-2017 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 TK78_RS01980 afb8c61d39f48a7476d3fb8e4fb38358 314 Pfam PF02911 Formyl transferase, C-terminal domain 204 305 1.2E-16 T 09-03-2017 IPR005793 Formyl transferase, C-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 TK78_RS01980 afb8c61d39f48a7476d3fb8e4fb38358 314 Pfam PF00551 Formyl transferase 1 172 4.7E-32 T 09-03-2017 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 TK78_RS01980 afb8c61d39f48a7476d3fb8e4fb38358 314 SUPERFAMILY SSF50486 204 307 1.05E-19 T 09-03-2017 IPR011034 Formyl transferase, C-terminal-like GO:0003824 TK78_RS05035 c96de96552818e2ae8a83ba3e718fe49 536 Pfam PF02838 Glycosyl hydrolase family 20, domain 2 9 135 1.3E-17 T 09-03-2017 IPR015882 Beta-hexosaminidase, bacteial type, N-terminal KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 TK78_RS05035 c96de96552818e2ae8a83ba3e718fe49 536 Gene3D G3DSA:3.30.379.10 3 135 2.2E-25 T 09-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS05035 c96de96552818e2ae8a83ba3e718fe49 536 Gene3D G3DSA:3.20.20.80 137 517 1.3E-113 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS05035 c96de96552818e2ae8a83ba3e718fe49 536 SUPERFAMILY SSF51445 140 497 4.21E-101 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS05035 c96de96552818e2ae8a83ba3e718fe49 536 Pfam PF00728 Glycosyl hydrolase family 20, catalytic domain 140 485 1.6E-99 T 09-03-2017 IPR015883 Glycoside hydrolase family 20, catalytic domain GO:0004553|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 TK78_RS05035 c96de96552818e2ae8a83ba3e718fe49 536 PRINTS PR00738 Glycosyl hydrolase family 20 signature 283 301 6.5E-43 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS05035 c96de96552818e2ae8a83ba3e718fe49 536 PRINTS PR00738 Glycosyl hydrolase family 20 signature 162 183 6.5E-43 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS05035 c96de96552818e2ae8a83ba3e718fe49 536 PRINTS PR00738 Glycosyl hydrolase family 20 signature 235 252 6.5E-43 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS05035 c96de96552818e2ae8a83ba3e718fe49 536 PRINTS PR00738 Glycosyl hydrolase family 20 signature 305 318 6.5E-43 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS05035 c96de96552818e2ae8a83ba3e718fe49 536 PRINTS PR00738 Glycosyl hydrolase family 20 signature 90 110 6.5E-43 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS05035 c96de96552818e2ae8a83ba3e718fe49 536 PRINTS PR00738 Glycosyl hydrolase family 20 signature 133 150 6.5E-43 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS05035 c96de96552818e2ae8a83ba3e718fe49 536 PRINTS PR00738 Glycosyl hydrolase family 20 signature 467 484 6.5E-43 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS05035 c96de96552818e2ae8a83ba3e718fe49 536 PRINTS PR00738 Glycosyl hydrolase family 20 signature 449 465 6.5E-43 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS05035 c96de96552818e2ae8a83ba3e718fe49 536 SUPERFAMILY SSF55545 4 137 3.14E-21 T 09-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS20230 4abb5338e79caff3cba876785b5cf0f9 418 SUPERFAMILY SSF88713 82 130 5.84E-27 T 09-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 TK78_RS20230 4abb5338e79caff3cba876785b5cf0f9 418 SUPERFAMILY SSF88713 160 391 5.84E-27 T 09-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 TK78_RS20230 4abb5338e79caff3cba876785b5cf0f9 418 Gene3D G3DSA:3.20.20.370 87 391 1.1E-13 T 09-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 TK78_RS02250 e21931b6f9c3a90211306ca6ff50cf2a 220 SUPERFAMILY SSF63817 72 219 2.35E-14 T 09-03-2017 IPR023365 Sortase domain TK78_RS02250 e21931b6f9c3a90211306ca6ff50cf2a 220 Pfam PF04203 Sortase family 78 217 9.9E-16 T 09-03-2017 IPR005754 Sortase family TK78_RS02250 e21931b6f9c3a90211306ca6ff50cf2a 220 Gene3D G3DSA:2.40.260.10 76 218 5.8E-4 T 09-03-2017 IPR023365 Sortase domain TK78_RS11325 a0ffa658d3ad584561d7eef6774c1bf0 116 Gene3D G3DSA:3.30.429.10 2 112 5.2E-21 T 09-03-2017 TK78_RS11325 a0ffa658d3ad584561d7eef6774c1bf0 116 SUPERFAMILY SSF55331 2 113 3.83E-20 T 09-03-2017 IPR014347 Tautomerase/MIF superfamily TK78_RS21645 1fdb819592dab6f6f7c34d55f00aa66e 468 ProSitePatterns PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 33 51 - T 09-03-2017 IPR001216 Cysteine synthase/cystathionine beta-synthase, pyridoxal-phosphate attachment site GO:0006535 TK78_RS21645 1fdb819592dab6f6f7c34d55f00aa66e 468 SUPERFAMILY SSF53686 3 317 1.7E-99 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS21645 1fdb819592dab6f6f7c34d55f00aa66e 468 Gene3D G3DSA:3.10.580.10 332 461 6.1E-20 T 09-03-2017 TK78_RS21645 1fdb819592dab6f6f7c34d55f00aa66e 468 Pfam PF00571 CBS domain 409 460 0.0019 T 09-03-2017 IPR000644 CBS domain TK78_RS21645 1fdb819592dab6f6f7c34d55f00aa66e 468 Pfam PF00571 CBS domain 338 394 1.4E-4 T 09-03-2017 IPR000644 CBS domain TK78_RS21645 1fdb819592dab6f6f7c34d55f00aa66e 468 SUPERFAMILY SSF54631 340 461 1.17E-14 T 09-03-2017 TK78_RS21645 1fdb819592dab6f6f7c34d55f00aa66e 468 Gene3D G3DSA:3.40.50.1100 43 147 1.7E-39 T 09-03-2017 TK78_RS21645 1fdb819592dab6f6f7c34d55f00aa66e 468 SMART SM00116 412 460 3.2 T 09-03-2017 IPR000644 CBS domain TK78_RS21645 1fdb819592dab6f6f7c34d55f00aa66e 468 SMART SM00116 339 395 0.12 T 09-03-2017 IPR000644 CBS domain TK78_RS21645 1fdb819592dab6f6f7c34d55f00aa66e 468 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 10 296 6.2E-72 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS21645 1fdb819592dab6f6f7c34d55f00aa66e 468 Gene3D G3DSA:3.40.50.1100 2 42 1.7E-72 T 09-03-2017 TK78_RS21645 1fdb819592dab6f6f7c34d55f00aa66e 468 Gene3D G3DSA:3.40.50.1100 153 313 1.7E-72 T 09-03-2017 TK78_RS21645 1fdb819592dab6f6f7c34d55f00aa66e 468 TIGRFAM TIGR01137 cysta_beta: cystathionine beta-synthase 4 460 3.7E-208 T 09-03-2017 IPR005857 Cystathionine beta-synthase GO:0004122|GO:0005737|GO:0019343 KEGG: 00260+4.2.1.22|KEGG: 00270+4.2.1.22|MetaCyc: PWY-801 TK78_RS29385 c79c2388d64830391b2a29cb08c7ca53 326 Gene3D G3DSA:3.10.50.40 45 195 1.5E-6 T 09-03-2017 TK78_RS29385 c79c2388d64830391b2a29cb08c7ca53 326 SUPERFAMILY SSF54534 54 182 5.18E-5 T 09-03-2017 TK78_RS29385 c79c2388d64830391b2a29cb08c7ca53 326 Pfam PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 236 323 8.1E-18 T 09-03-2017 IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain GO:0006457 TK78_RS29385 c79c2388d64830391b2a29cb08c7ca53 326 Gene3D G3DSA:3.10.50.40 218 324 2.6E-26 T 09-03-2017 TK78_RS29385 c79c2388d64830391b2a29cb08c7ca53 326 SUPERFAMILY SSF54534 208 323 4.52E-26 T 09-03-2017 TK78_RS34020 f7d8fd5b1ca865c4a9dc7274daf9c1e0 183 SMART SM00641 2 101 7.2E-18 T 09-03-2017 IPR018077 Glycoside hydrolase, family 25 subgroup TK78_RS34020 f7d8fd5b1ca865c4a9dc7274daf9c1e0 183 SUPERFAMILY SSF51445 3 176 1.97E-34 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS34020 f7d8fd5b1ca865c4a9dc7274daf9c1e0 183 Gene3D G3DSA:3.20.20.80 2 169 1.5E-38 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS34020 f7d8fd5b1ca865c4a9dc7274daf9c1e0 183 Pfam PF01183 Glycosyl hydrolases family 25 5 163 3.6E-38 T 09-03-2017 IPR002053 Glycoside hydrolase, family 25 GO:0003796|GO:0009253|GO:0016998 TK78_RS05495 8a8ad59a36ae509515ef1cef30f0adf9 444 Gene3D G3DSA:2.40.30.10 229 353 1.5E-18 T 09-03-2017 TK78_RS05495 8a8ad59a36ae509515ef1cef30f0adf9 444 Gene3D G3DSA:3.40.50.300 6 218 3.8E-62 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS05495 8a8ad59a36ae509515ef1cef30f0adf9 444 ProSitePatterns PS00301 Translational (tr)-type guanine nucleotide-binding (G) domain signature. 67 82 - T 09-03-2017 IPR031157 Tr-type G domain, conserved site TK78_RS05495 8a8ad59a36ae509515ef1cef30f0adf9 444 SUPERFAMILY SSF50447 228 317 1.13E-17 T 09-03-2017 IPR009000 Translation protein, beta-barrel domain TK78_RS05495 8a8ad59a36ae509515ef1cef30f0adf9 444 SUPERFAMILY SSF50465 320 421 2.49E-24 T 09-03-2017 IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal TK78_RS05495 8a8ad59a36ae509515ef1cef30f0adf9 444 Pfam PF00009 Elongation factor Tu GTP binding domain 14 197 3.8E-40 T 09-03-2017 TK78_RS05495 8a8ad59a36ae509515ef1cef30f0adf9 444 TIGRFAM TIGR02034 CysN: sulfate adenylyltransferase, large subunit 14 421 1.4E-164 T 09-03-2017 IPR011779 Sulphate adenylyltransferase, large subunit GO:0006790 KEGG: 00230+2.7.7.4|KEGG: 00261+2.7.7.4|KEGG: 00450+2.7.7.4|KEGG: 00920+2.7.7.4|MetaCyc: PWY-5278|MetaCyc: PWY-5340|MetaCyc: PWY-6683|MetaCyc: PWY-6932 TK78_RS05495 8a8ad59a36ae509515ef1cef30f0adf9 444 SUPERFAMILY SSF52540 13 218 4.53E-53 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS05495 8a8ad59a36ae509515ef1cef30f0adf9 444 PRINTS PR00315 GTP-binding elongation factor signature 94 104 2.4E-12 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS05495 8a8ad59a36ae509515ef1cef30f0adf9 444 PRINTS PR00315 GTP-binding elongation factor signature 147 156 2.4E-12 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS05495 8a8ad59a36ae509515ef1cef30f0adf9 444 PRINTS PR00315 GTP-binding elongation factor signature 110 121 2.4E-12 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS05495 8a8ad59a36ae509515ef1cef30f0adf9 444 PRINTS PR00315 GTP-binding elongation factor signature 15 28 2.4E-12 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS05495 8a8ad59a36ae509515ef1cef30f0adf9 444 PRINTS PR00315 GTP-binding elongation factor signature 74 82 2.4E-12 T 09-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TK78_RS02190 d524b266f26448aec72f7c813fa885c8 822 ProSitePatterns PS00211 ABC transporters family signature. 707 721 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS02190 d524b266f26448aec72f7c813fa885c8 822 SUPERFAMILY SSF52540 488 787 5.01E-46 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS02190 d524b266f26448aec72f7c813fa885c8 822 Pfam PF00005 ABC transporter 499 737 1.7E-9 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS02190 d524b266f26448aec72f7c813fa885c8 822 ProSitePatterns PS00211 ABC transporters family signature. 361 375 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS02190 d524b266f26448aec72f7c813fa885c8 822 SUPERFAMILY SSF52540 199 221 3.25E-26 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS02190 d524b266f26448aec72f7c813fa885c8 822 SUPERFAMILY SSF52540 348 452 3.25E-26 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS02190 d524b266f26448aec72f7c813fa885c8 822 SUPERFAMILY SSF52540 10 117 3.25E-26 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS02190 d524b266f26448aec72f7c813fa885c8 822 Gene3D G3DSA:3.40.50.300 352 466 4.3E-47 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS02190 d524b266f26448aec72f7c813fa885c8 822 Gene3D G3DSA:3.40.50.300 698 816 2.5E-54 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS02190 d524b266f26448aec72f7c813fa885c8 822 Gene3D G3DSA:3.40.50.300 479 545 2.5E-54 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS02190 d524b266f26448aec72f7c813fa885c8 822 Gene3D G3DSA:3.40.50.300 8 56 4.3E-47 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS02190 d524b266f26448aec72f7c813fa885c8 822 Gene3D G3DSA:1.10.8.280 159 270 1.2E-25 T 09-03-2017 TK78_RS02190 d524b266f26448aec72f7c813fa885c8 822 SMART SM00382 28 438 14.0 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS02190 d524b266f26448aec72f7c813fa885c8 822 SMART SM00382 506 785 8.7E-4 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS02190 d524b266f26448aec72f7c813fa885c8 822 TIGRFAM TIGR00630 uvra: excinuclease ABC subunit A 128 802 3.3E-222 T 09-03-2017 IPR004602 UvrABC system subunit A GO:0006289|GO:0009380|GO:0009381 TK78_RS02190 d524b266f26448aec72f7c813fa885c8 822 Gene3D G3DSA:1.20.1580.10 571 697 5.0E-47 T 09-03-2017 TK78_RS02190 d524b266f26448aec72f7c813fa885c8 822 Gene3D G3DSA:1.20.1580.10 271 351 9.1E-29 T 09-03-2017 TK78_RS02190 d524b266f26448aec72f7c813fa885c8 822 Gene3D G3DSA:1.20.1580.10 99 158 9.1E-29 T 09-03-2017 TK78_RS28000 6858615c89e6fde7ef58ca141a5be8a3 422 TIGRFAM TIGR01979 sufS: cysteine desulfurase, SufS family 16 422 1.6E-185 T 09-03-2017 IPR010970 Cysteine desulfurase, SufS GO:0006534|GO:0030170|GO:0031071 KEGG: 00730+2.8.1.7|MetaCyc: PWY-6823|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7250 TK78_RS28000 6858615c89e6fde7ef58ca141a5be8a3 422 Gene3D G3DSA:3.40.640.10 46 297 4.0E-85 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS28000 6858615c89e6fde7ef58ca141a5be8a3 422 Gene3D G3DSA:3.90.1150.10 298 416 2.8E-27 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS28000 6858615c89e6fde7ef58ca141a5be8a3 422 Pfam PF00266 Aminotransferase class-V 35 410 1.1E-150 T 09-03-2017 IPR000192 Aminotransferase class V domain TK78_RS28000 6858615c89e6fde7ef58ca141a5be8a3 422 SUPERFAMILY SSF53383 13 417 9.79E-122 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS19625 e345c511acd026ad2cd1602beb766d7a 370 SUPERFAMILY SSF82829 261 365 3.14E-15 T 09-03-2017 TK78_RS19625 e345c511acd026ad2cd1602beb766d7a 370 Gene3D G3DSA:3.40.50.620 71 233 8.9E-12 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS19625 e345c511acd026ad2cd1602beb766d7a 370 Pfam PF01171 PP-loop family 71 249 7.6E-38 T 09-03-2017 IPR011063 tRNA(Ile)-lysidine/2-thiocytidine synthase, N-terminal Reactome: R-HSA-6782315 TK78_RS19625 e345c511acd026ad2cd1602beb766d7a 370 TIGRFAM TIGR02432 lysidine_TilS_N: tRNA(Ile)-lysidine synthetase 71 252 3.6E-43 T 09-03-2017 IPR012795 tRNA(Ile)-lysidine synthase, N-terminal GO:0000166|GO:0005524|GO:0005737|GO:0008033|GO:0016879 TK78_RS19625 e345c511acd026ad2cd1602beb766d7a 370 Hamap MF_01161 tRNA(Ile)-lysidine synthase [tilS]. 58 359 19.862 T 09-03-2017 IPR012094 tRNA(Ile)-lysidine synthase GO:0000166|GO:0005524|GO:0005737|GO:0008033|GO:0016879 TK78_RS19625 e345c511acd026ad2cd1602beb766d7a 370 Pfam PF09179 TilS substrate binding domain 298 365 7.6E-11 T 09-03-2017 IPR015262 tRNA(Ile)-lysidine synthase , substrate-binding domain GO:0000166|GO:0005524|GO:0005737|GO:0008033|GO:0016879 TK78_RS19625 e345c511acd026ad2cd1602beb766d7a 370 SUPERFAMILY SSF52402 71 281 6.28E-44 T 09-03-2017 TK78_RS21205 a836364c97a7985ea817c860328c8a58 303 Pfam PF00288 GHMP kinases N terminal domain 92 150 2.6E-5 T 09-03-2017 IPR006204 GHMP kinase N-terminal domain GO:0005524 TK78_RS21205 a836364c97a7985ea817c860328c8a58 303 SUPERFAMILY SSF54211 8 164 8.35E-42 T 09-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold TK78_RS21205 a836364c97a7985ea817c860328c8a58 303 Gene3D G3DSA:3.30.230.10 8 165 2.0E-49 T 09-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TK78_RS21205 a836364c97a7985ea817c860328c8a58 303 TIGRFAM TIGR00154 ispE: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase 9 277 8.9E-49 T 09-03-2017 IPR004424 4-diphosphocytidyl-2C-methyl-D-erythritol kinase GO:0016114|GO:0050515 KEGG: 00710+2.7.1.14|KEGG: 00900+2.7.1.148|MetaCyc: PWY-7560 TK78_RS21205 a836364c97a7985ea817c860328c8a58 303 Hamap MF_00061 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [ispE]. 8 294 29.884 T 09-03-2017 IPR004424 4-diphosphocytidyl-2C-methyl-D-erythritol kinase GO:0016114|GO:0050515 KEGG: 00710+2.7.1.14|KEGG: 00900+2.7.1.148|MetaCyc: PWY-7560 TK78_RS21205 a836364c97a7985ea817c860328c8a58 303 Pfam PF08544 GHMP kinases C terminal 209 280 6.9E-8 T 09-03-2017 IPR013750 GHMP kinase, C-terminal domain TK78_RS21205 a836364c97a7985ea817c860328c8a58 303 SUPERFAMILY SSF55060 170 280 2.01E-20 T 09-03-2017 IPR013750 GHMP kinase, C-terminal domain TK78_RS21205 a836364c97a7985ea817c860328c8a58 303 PIRSF PIRSF010376 7 301 5.9E-75 T 09-03-2017 IPR004424 4-diphosphocytidyl-2C-methyl-D-erythritol kinase GO:0016114|GO:0050515 KEGG: 00710+2.7.1.14|KEGG: 00900+2.7.1.148|MetaCyc: PWY-7560 TK78_RS21205 a836364c97a7985ea817c860328c8a58 303 Gene3D G3DSA:3.30.70.890 170 284 4.6E-24 T 09-03-2017 IPR013750 GHMP kinase, C-terminal domain TK78_RS18260 e78a4b7956901a2a6335691c0772af6a 265 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 22 160 3.0E-19 T 09-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 TK78_RS18260 e78a4b7956901a2a6335691c0772af6a 265 Gene3D G3DSA:1.20.120.450 20 64 1.6E-8 T 09-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase TK78_RS18260 e78a4b7956901a2a6335691c0772af6a 265 TIGRFAM TIGR03083 TIGR03083: uncharacterized Actinobacterial protein TIGR03083 20 236 1.8E-25 T 09-03-2017 IPR017517 Conserved hypothetical protein CHP03083, actinobacterial-type TK78_RS18260 e78a4b7956901a2a6335691c0772af6a 265 SUPERFAMILY SSF109854 12 166 1.08E-18 T 09-03-2017 TK78_RS05120 e83a4caf4c3ff80b58dbc45fa9777123 131 Gene3D G3DSA:3.10.180.10 4 126 3.5E-11 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS05120 e83a4caf4c3ff80b58dbc45fa9777123 131 SUPERFAMILY SSF54593 7 123 1.17E-9 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS28510 8a59e4ef576f5dff48edcb09bca3e0b0 326 ProSitePatterns PS01270 Band 7 protein family signature. 135 163 - T 09-03-2017 IPR018080 Band 7/stomatin-like, conserved site TK78_RS28510 8a59e4ef576f5dff48edcb09bca3e0b0 326 Pfam PF01145 SPFH domain / Band 7 family 25 194 1.1E-35 T 09-03-2017 IPR001107 Band 7 domain TK78_RS28510 8a59e4ef576f5dff48edcb09bca3e0b0 326 PRINTS PR00721 Stomatin signature 28 50 1.6E-31 T 09-03-2017 IPR001972 Stomatin family GO:0016020 TK78_RS28510 8a59e4ef576f5dff48edcb09bca3e0b0 326 PRINTS PR00721 Stomatin signature 131 154 1.6E-31 T 09-03-2017 IPR001972 Stomatin family GO:0016020 TK78_RS28510 8a59e4ef576f5dff48edcb09bca3e0b0 326 PRINTS PR00721 Stomatin signature 155 173 1.6E-31 T 09-03-2017 IPR001972 Stomatin family GO:0016020 TK78_RS28510 8a59e4ef576f5dff48edcb09bca3e0b0 326 PRINTS PR00721 Stomatin signature 174 195 1.6E-31 T 09-03-2017 IPR001972 Stomatin family GO:0016020 TK78_RS28510 8a59e4ef576f5dff48edcb09bca3e0b0 326 PRINTS PR00721 Stomatin signature 76 97 1.6E-31 T 09-03-2017 IPR001972 Stomatin family GO:0016020 TK78_RS28510 8a59e4ef576f5dff48edcb09bca3e0b0 326 PRINTS PR00721 Stomatin signature 111 128 1.6E-31 T 09-03-2017 IPR001972 Stomatin family GO:0016020 TK78_RS28510 8a59e4ef576f5dff48edcb09bca3e0b0 326 SMART SM00244 21 179 2.2E-52 T 09-03-2017 IPR001107 Band 7 domain TK78_RS28510 8a59e4ef576f5dff48edcb09bca3e0b0 326 SUPERFAMILY SSF117892 52 186 2.75E-39 T 09-03-2017 IPR001107 Band 7 domain TK78_RS14475 93351ed7ab72bc52cd68b280bd1751e3 289 SMART SM00530 18 73 1.4E-5 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS14475 93351ed7ab72bc52cd68b280bd1751e3 289 SUPERFAMILY SSF47413 15 69 2.22E-7 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS14475 93351ed7ab72bc52cd68b280bd1751e3 289 Pfam PF13560 Helix-turn-helix domain 15 74 4.3E-12 T 09-03-2017 TK78_RS14475 93351ed7ab72bc52cd68b280bd1751e3 289 Gene3D G3DSA:1.10.260.40 8 69 1.2E-9 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS10155 a3f255e58a41e9e23369c3fbf8b7ff11 293 Pfam PF13460 NAD(P)H-binding 10 183 3.1E-18 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS10155 a3f255e58a41e9e23369c3fbf8b7ff11 293 SUPERFAMILY SSF51735 7 235 2.17E-49 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS10155 a3f255e58a41e9e23369c3fbf8b7ff11 293 Gene3D G3DSA:3.40.50.720 7 218 2.6E-32 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31770 6faf234bcd50d6fe263c14721ae07e66 494 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 95 220 4.7E-16 T 09-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 TK78_RS31770 6faf234bcd50d6fe263c14721ae07e66 494 SUPERFAMILY SSF51735 85 253 2.18E-39 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31770 6faf234bcd50d6fe263c14721ae07e66 494 Gene3D G3DSA:3.40.50.720 94 277 1.1E-44 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS02435 bfb68a6818b61111f0dc38cf1e3cfaea 444 Pfam PF00480 ROK family 86 406 6.1E-37 T 09-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 TK78_RS02435 bfb68a6818b61111f0dc38cf1e3cfaea 444 Gene3D G3DSA:1.10.10.10 11 79 1.1E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS02435 bfb68a6818b61111f0dc38cf1e3cfaea 444 SUPERFAMILY SSF46785 12 75 2.26E-14 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS02435 bfb68a6818b61111f0dc38cf1e3cfaea 444 Gene3D G3DSA:3.30.420.40 80 233 6.2E-29 T 09-03-2017 TK78_RS02435 bfb68a6818b61111f0dc38cf1e3cfaea 444 Gene3D G3DSA:3.30.420.40 234 391 2.5E-37 T 09-03-2017 TK78_RS02435 bfb68a6818b61111f0dc38cf1e3cfaea 444 SUPERFAMILY SSF53067 83 408 6.48E-45 T 09-03-2017 TK78_RS26625 7a5f515a48d7cf704c347272e567eace 207 SMART SM00345 13 71 6.9E-15 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS26625 7a5f515a48d7cf704c347272e567eace 207 Gene3D G3DSA:1.10.10.10 7 72 5.6E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS26625 7a5f515a48d7cf704c347272e567eace 207 SMART SM00895 81 202 1.7E-7 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS26625 7a5f515a48d7cf704c347272e567eace 207 SUPERFAMILY SSF48008 78 192 2.62E-17 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS26625 7a5f515a48d7cf704c347272e567eace 207 SUPERFAMILY SSF46785 8 97 2.24E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS26625 7a5f515a48d7cf704c347272e567eace 207 Pfam PF00392 Bacterial regulatory proteins, gntR family 10 71 6.7E-17 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS26625 7a5f515a48d7cf704c347272e567eace 207 Gene3D G3DSA:1.20.120.530 74 191 1.7E-18 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS26625 7a5f515a48d7cf704c347272e567eace 207 Pfam PF07729 FCD domain 82 191 1.9E-15 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS19665 8bda528f3bb254bf7a2c6ebc6fc88b76 157 Gene3D G3DSA:3.10.450.50 7 155 8.8E-54 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS19665 8bda528f3bb254bf7a2c6ebc6fc88b76 157 Pfam PF13474 SnoaL-like domain 15 143 1.5E-31 T 09-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain TK78_RS19665 8bda528f3bb254bf7a2c6ebc6fc88b76 157 SUPERFAMILY SSF54427 9 143 1.36E-40 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS28080 88b99708515328a2ce1b74192cdc4572 269 SUPERFAMILY SSF51735 5 239 1.49E-42 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS28080 88b99708515328a2ce1b74192cdc4572 269 Pfam PF01370 NAD dependent epimerase/dehydratase family 7 167 4.6E-20 T 09-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 TK78_RS28080 88b99708515328a2ce1b74192cdc4572 269 Gene3D G3DSA:3.40.50.720 4 219 5.8E-35 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS06265 bbe6539f500ad884ac3cf8ce85d1b0a7 178 Gene3D G3DSA:2.60.40.230 54 177 2.9E-14 T 09-03-2017 IPR027273 Neocarzinostatin-like TK78_RS06265 bbe6539f500ad884ac3cf8ce85d1b0a7 178 SUPERFAMILY SSF49319 54 177 2.91E-17 T 09-03-2017 IPR027273 Neocarzinostatin-like TK78_RS24430 1c563b04e0f41b544ea090e9c7ba6eb4 506 Gene3D G3DSA:3.90.190.20 366 505 2.3E-38 T 09-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TK78_RS24430 1c563b04e0f41b544ea090e9c7ba6eb4 506 SUPERFAMILY SSF53244 366 504 2.56E-26 T 09-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TK78_RS24430 1c563b04e0f41b544ea090e9c7ba6eb4 506 SUPERFAMILY SSF53623 71 362 1.22E-88 T 09-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 TK78_RS24430 1c563b04e0f41b544ea090e9c7ba6eb4 506 ProSitePatterns PS01012 Folylpolyglutamate synthase signature 2. 205 220 - T 09-03-2017 IPR018109 Folylpolyglutamate synthetase, conserved site GO:0004326|GO:0005524|GO:0009396 Reactome: R-HSA-196757 TK78_RS24430 1c563b04e0f41b544ea090e9c7ba6eb4 506 TIGRFAM TIGR01499 folC: bifunctional protein FolC 88 500 8.6E-102 T 09-03-2017 IPR001645 Folylpolyglutamate synthetase GO:0004326|GO:0005524|GO:0009396 KEGG: 00790+6.3.2.17|MetaCyc: PWY-2161|Reactome: R-HSA-196757 TK78_RS24430 1c563b04e0f41b544ea090e9c7ba6eb4 506 Pfam PF08245 Mur ligase middle domain 109 336 3.4E-16 T 09-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 TK78_RS24430 1c563b04e0f41b544ea090e9c7ba6eb4 506 Pfam PF02875 Mur ligase family, glutamate ligase domain 365 444 5.0E-12 T 09-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TK78_RS24430 1c563b04e0f41b544ea090e9c7ba6eb4 506 Gene3D G3DSA:3.40.1190.10 84 362 6.3E-94 T 09-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 TK78_RS12355 54e3ec0f942e5d87c196e50bb2cfb473 584 SUPERFAMILY SSF51905 2 259 1.81E-68 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS12355 54e3ec0f942e5d87c196e50bb2cfb473 584 SUPERFAMILY SSF51905 358 429 1.81E-68 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS12355 54e3ec0f942e5d87c196e50bb2cfb473 584 Pfam PF02910 Fumarate reductase flavoprotein C-term 454 584 1.0E-45 T 09-03-2017 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS12355 54e3ec0f942e5d87c196e50bb2cfb473 584 SUPERFAMILY SSF46977 446 584 3.01E-51 T 09-03-2017 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS12355 54e3ec0f942e5d87c196e50bb2cfb473 584 PIRSF PIRSF000171 1 578 2.3E-47 T 09-03-2017 IPR030664 Succinate dehydrogenase/fumarate reductase, alpha/adenylylsulphate reductase subunit Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS12355 54e3ec0f942e5d87c196e50bb2cfb473 584 Gene3D G3DSA:3.90.700.10 243 349 3.8E-41 T 09-03-2017 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS12355 54e3ec0f942e5d87c196e50bb2cfb473 584 Gene3D G3DSA:3.50.50.60 350 421 7.3E-110 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS12355 54e3ec0f942e5d87c196e50bb2cfb473 584 Gene3D G3DSA:3.50.50.60 2 242 7.3E-110 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS12355 54e3ec0f942e5d87c196e50bb2cfb473 584 TIGRFAM TIGR01812 sdhA_frdA_Gneg: succinate dehydrogenase or fumarate reductase, flavoprotein subunit 7 584 4.7E-246 T 09-03-2017 IPR014006 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit GO:0016627|GO:0022900|GO:0050660|GO:0055114 KEGG: 00020+1.3.5.1|KEGG: 00190+1.3.5.1|KEGG: 00650+1.3.5.1|KEGG: 00720+1.3.5.1|MetaCyc: PWY-3781|MetaCyc: PWY-4302|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7279|Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS12355 54e3ec0f942e5d87c196e50bb2cfb473 584 Pfam PF00890 FAD binding domain 7 400 3.4E-109 T 09-03-2017 IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS12355 54e3ec0f942e5d87c196e50bb2cfb473 584 Gene3D G3DSA:1.20.58.100 426 542 1.9E-43 T 09-03-2017 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS12355 54e3ec0f942e5d87c196e50bb2cfb473 584 SUPERFAMILY SSF56425 236 354 1.47E-42 T 09-03-2017 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS12355 54e3ec0f942e5d87c196e50bb2cfb473 584 TIGRFAM TIGR01816 sdhA_forward: succinate dehydrogenase, flavoprotein subunit 4 584 3.4E-275 T 09-03-2017 IPR011281 Succinate dehydrogenase, flavoprotein subunit GO:0006099|GO:0016627|GO:0050660|GO:0055114 KEGG: 00020+1.3.5.1|KEGG: 00190+1.3.5.1|KEGG: 00650+1.3.5.1|KEGG: 00720+1.3.5.1|MetaCyc: PWY-3781|MetaCyc: PWY-4302|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7279|Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS12355 54e3ec0f942e5d87c196e50bb2cfb473 584 ProSitePatterns PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. 40 49 - T 09-03-2017 IPR003952 Fumarate reductase/succinate dehydrogenase, FAD-binding site GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS12355 54e3ec0f942e5d87c196e50bb2cfb473 584 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 363 385 4.1E-5 T 09-03-2017 TK78_RS12355 54e3ec0f942e5d87c196e50bb2cfb473 584 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 8 27 4.1E-5 T 09-03-2017 TK78_RS12355 54e3ec0f942e5d87c196e50bb2cfb473 584 Gene3D G3DSA:4.10.80.40 543 580 9.6E-18 T 09-03-2017 TK78_RS02875 e6802b73719caedcf28b14d6732d181e 688 TIGRFAM TIGR03396 PC_PLC: phospholipase C, phosphocholine-specific 5 684 8.5E-255 T 09-03-2017 IPR017767 Bacterial phospholipase C, phosphocholine-specific GO:0034480 KEGG: 00562+3.1.4.3|KEGG: 00564+3.1.4.3|KEGG: 00565+3.1.4.3 TK78_RS02875 e6802b73719caedcf28b14d6732d181e 688 Pfam PF04185 Phosphoesterase family 44 429 1.6E-115 T 09-03-2017 IPR007312 Phosphoesterase GO:0016788 TK78_RS02875 e6802b73719caedcf28b14d6732d181e 688 Pfam PF05506 Domain of unknown function (DUF756) 497 582 2.6E-17 T 09-03-2017 IPR008475 Bacterial phospholipase C, C-terminal domain GO:0004629|GO:0016042 KEGG: 00562+3.1.4.3|KEGG: 00564+3.1.4.3|KEGG: 00565+3.1.4.3 TK78_RS02875 e6802b73719caedcf28b14d6732d181e 688 Pfam PF05506 Domain of unknown function (DUF756) 594 672 2.9E-16 T 09-03-2017 IPR008475 Bacterial phospholipase C, C-terminal domain GO:0004629|GO:0016042 KEGG: 00562+3.1.4.3|KEGG: 00564+3.1.4.3|KEGG: 00565+3.1.4.3 TK78_RS14485 0965411ba36bba1abe7434471af6539b 484 Pfam PF13556 PucR C-terminal helix-turn-helix domain 302 357 5.2E-8 T 09-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain TK78_RS14485 0965411ba36bba1abe7434471af6539b 484 Pfam PF13556 PucR C-terminal helix-turn-helix domain 407 462 6.6E-11 T 09-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain TK78_RS06765 2aa6b9b0db79f8bfdfd378a4d9f95ecc 389 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 328 337 - T 09-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 TK78_RS06765 2aa6b9b0db79f8bfdfd378a4d9f95ecc 389 Pfam PF00067 Cytochrome P450 26 358 5.4E-27 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS06765 2aa6b9b0db79f8bfdfd378a4d9f95ecc 389 SUPERFAMILY SSF48264 18 388 1.14E-88 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS06765 2aa6b9b0db79f8bfdfd378a4d9f95ecc 389 Gene3D G3DSA:1.10.630.10 17 385 6.3E-109 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS06765 2aa6b9b0db79f8bfdfd378a4d9f95ecc 389 PRINTS PR00359 B-class P450 signature 132 147 1.0E-53 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS06765 2aa6b9b0db79f8bfdfd378a4d9f95ecc 389 PRINTS PR00359 B-class P450 signature 326 335 1.0E-53 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS06765 2aa6b9b0db79f8bfdfd378a4d9f95ecc 389 PRINTS PR00359 B-class P450 signature 179 201 1.0E-53 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS06765 2aa6b9b0db79f8bfdfd378a4d9f95ecc 389 PRINTS PR00359 B-class P450 signature 260 271 1.0E-53 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS06765 2aa6b9b0db79f8bfdfd378a4d9f95ecc 389 PRINTS PR00359 B-class P450 signature 65 76 1.0E-53 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS06765 2aa6b9b0db79f8bfdfd378a4d9f95ecc 389 PRINTS PR00359 B-class P450 signature 305 320 1.0E-53 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS06765 2aa6b9b0db79f8bfdfd378a4d9f95ecc 389 PRINTS PR00359 B-class P450 signature 115 131 1.0E-53 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS06765 2aa6b9b0db79f8bfdfd378a4d9f95ecc 389 PRINTS PR00359 B-class P450 signature 277 304 1.0E-53 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS06765 2aa6b9b0db79f8bfdfd378a4d9f95ecc 389 PRINTS PR00359 B-class P450 signature 335 346 1.0E-53 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS00205 147dd03711ebd05c8ad0414777700432 194 Pfam PF13613 Helix-turn-helix of DDE superfamily endonuclease 18 68 6.4E-15 T 09-03-2017 IPR027805 Transposase, Helix-turn-helix domain TK78_RS03200 66ce05cbe96f5a9d0b70214137751419 325 TIGRFAM TIGR01179 galE: UDP-glucose 4-epimerase GalE 4 317 1.7E-96 T 09-03-2017 IPR005886 UDP-glucose 4-epimerase GalE GO:0003978|GO:0006012 KEGG: 00052+5.1.3.2|KEGG: 00520+5.1.3.2|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6397|MetaCyc: PWY-6527|MetaCyc: PWY-7328|MetaCyc: PWY-7344|Reactome: R-HSA-5609977|Reactome: R-HSA-70370 TK78_RS03200 66ce05cbe96f5a9d0b70214137751419 325 Pfam PF01370 NAD dependent epimerase/dehydratase family 3 249 3.4E-53 T 09-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 TK78_RS03200 66ce05cbe96f5a9d0b70214137751419 325 Gene3D G3DSA:3.40.50.720 1 169 1.0E-47 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS03200 66ce05cbe96f5a9d0b70214137751419 325 Gene3D G3DSA:3.90.25.10 251 321 1.2E-33 T 09-03-2017 TK78_RS03200 66ce05cbe96f5a9d0b70214137751419 325 Gene3D G3DSA:3.90.25.10 170 218 1.2E-33 T 09-03-2017 TK78_RS03200 66ce05cbe96f5a9d0b70214137751419 325 SUPERFAMILY SSF51735 1 316 3.61E-84 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31975 dd9d9d9b85d3f2abd6b52a3f1a8328a6 414 SUPERFAMILY SSF51395 4 351 3.95E-98 T 09-03-2017 TK78_RS31975 dd9d9d9b85d3f2abd6b52a3f1a8328a6 414 Pfam PF00724 NADH:flavin oxidoreductase / NADH oxidase family 4 342 1.3E-50 T 09-03-2017 IPR001155 NADH:flavin oxidoreductase/NADH oxidase, N-terminal GO:0010181|GO:0016491|GO:0055114 TK78_RS31975 dd9d9d9b85d3f2abd6b52a3f1a8328a6 414 Gene3D G3DSA:3.20.20.70 4 346 3.6E-105 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS30375 28e47a9a8f7ca07757ab789e663c0c9e 477 Pfam PF01189 16S rRNA methyltransferase RsmB/F 282 474 7.8E-43 T 09-03-2017 IPR001678 SAM-dependent methyltransferase RsmB/NOP2-type GO:0008168 KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 TK78_RS30375 28e47a9a8f7ca07757ab789e663c0c9e 477 ProSitePatterns PS01153 NOL1/NOP2/sun family signature. 351 362 - T 09-03-2017 IPR018314 Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site GO:0003723|GO:0008168 KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 TK78_RS30375 28e47a9a8f7ca07757ab789e663c0c9e 477 SUPERFAMILY SSF53335 168 475 4.63E-52 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS30375 28e47a9a8f7ca07757ab789e663c0c9e 477 SUPERFAMILY SSF48013 21 179 5.49E-34 T 09-03-2017 IPR006027 NusB/RsmB/TIM44 GO:0003723|GO:0006355 TK78_RS30375 28e47a9a8f7ca07757ab789e663c0c9e 477 Gene3D G3DSA:3.40.50.150 263 475 3.6E-42 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS30375 28e47a9a8f7ca07757ab789e663c0c9e 477 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 352 364 5.6E-19 T 09-03-2017 IPR023267 RNA (C5-cytosine) methyltransferase KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 TK78_RS30375 28e47a9a8f7ca07757ab789e663c0c9e 477 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 402 418 5.6E-19 T 09-03-2017 IPR023267 RNA (C5-cytosine) methyltransferase KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 TK78_RS30375 28e47a9a8f7ca07757ab789e663c0c9e 477 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 286 296 5.6E-19 T 09-03-2017 IPR023267 RNA (C5-cytosine) methyltransferase KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 TK78_RS30375 28e47a9a8f7ca07757ab789e663c0c9e 477 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 458 475 5.6E-19 T 09-03-2017 IPR023267 RNA (C5-cytosine) methyltransferase KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 TK78_RS30375 28e47a9a8f7ca07757ab789e663c0c9e 477 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 253 267 5.6E-19 T 09-03-2017 IPR023267 RNA (C5-cytosine) methyltransferase KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 TK78_RS30375 28e47a9a8f7ca07757ab789e663c0c9e 477 Pfam PF01029 NusB family 21 146 1.1E-24 T 09-03-2017 IPR006027 NusB/RsmB/TIM44 GO:0003723|GO:0006355 TK78_RS30375 28e47a9a8f7ca07757ab789e663c0c9e 477 Gene3D G3DSA:1.10.940.10 17 180 2.4E-46 T 09-03-2017 IPR006027 NusB/RsmB/TIM44 GO:0003723|GO:0006355 TK78_RS28580 9b43d548e2c06408f003190c81538af3 115 Gene3D G3DSA:3.30.1050.10 10 115 8.0E-16 T 09-03-2017 IPR003033 SCP2 sterol-binding domain TK78_RS28580 9b43d548e2c06408f003190c81538af3 115 Pfam PF02036 SCP-2 sterol transfer family 20 102 7.5E-6 T 09-03-2017 IPR003033 SCP2 sterol-binding domain TK78_RS28580 9b43d548e2c06408f003190c81538af3 115 SUPERFAMILY SSF55718 11 115 1.95E-15 T 09-03-2017 IPR003033 SCP2 sterol-binding domain TK78_RS25520 bb6680d1e9924e7f014f4ed41480770c 150 SMART SM00422 26 95 8.5E-18 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS25520 bb6680d1e9924e7f014f4ed41480770c 150 SUPERFAMILY SSF46955 26 140 1.28E-28 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS25520 bb6680d1e9924e7f014f4ed41480770c 150 Gene3D G3DSA:1.10.1660.10 26 142 3.7E-31 T 09-03-2017 TK78_RS25520 bb6680d1e9924e7f014f4ed41480770c 150 Pfam PF13411 MerR HTH family regulatory protein 26 88 1.2E-14 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS25060 2171b959a9f7e43ed79ac8768e29bbfc 324 Pfam PF00775 Dioxygenase 120 195 7.4E-10 T 09-03-2017 IPR000627 Intradiol ring-cleavage dioxygenase, C-terminal GO:0003824|GO:0006725|GO:0008199|GO:0055114 TK78_RS25060 2171b959a9f7e43ed79ac8768e29bbfc 324 SUPERFAMILY SSF49482 18 287 4.58E-41 T 09-03-2017 IPR015889 Intradiol ring-cleavage dioxygenase, core GO:0005506|GO:0016702|GO:0055114 TK78_RS25060 2171b959a9f7e43ed79ac8768e29bbfc 324 Gene3D G3DSA:2.60.130.10 68 261 1.1E-35 T 09-03-2017 IPR015889 Intradiol ring-cleavage dioxygenase, core GO:0005506|GO:0016702|GO:0055114 TK78_RS20870 0a6b4e2c643a6659787d78fa6283a94f 113 TIGRFAM TIGR02605 CxxC_CxxC_SSSS: putative regulatory protein, FmdB family 2 51 7.9E-19 T 09-03-2017 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain TK78_RS20870 0a6b4e2c643a6659787d78fa6283a94f 113 SMART SM00834 2 41 3.7E-13 T 09-03-2017 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain TK78_RS20870 0a6b4e2c643a6659787d78fa6283a94f 113 Pfam PF09723 Zinc ribbon domain 2 40 7.1E-13 T 09-03-2017 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain TK78_RS09975 8fe87ef24b1c7ad8f4c88b96ebf44b4e 254 Gene3D G3DSA:3.20.20.370 53 242 9.8E-65 T 09-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 TK78_RS09975 8fe87ef24b1c7ad8f4c88b96ebf44b4e 254 Pfam PF01522 Polysaccharide deacetylase 55 174 3.4E-38 T 09-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 TK78_RS09975 8fe87ef24b1c7ad8f4c88b96ebf44b4e 254 SUPERFAMILY SSF88713 53 242 6.67E-60 T 09-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 TK78_RS23945 59760dcdd67884398ccd159d234ab5db 655 SUPERFAMILY SSF52467 211 389 9.13E-43 T 09-03-2017 IPR029035 DHS-like NAD/FAD-binding domain TK78_RS23945 59760dcdd67884398ccd159d234ab5db 655 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 444 606 3.8E-37 T 09-03-2017 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 TK78_RS23945 59760dcdd67884398ccd159d234ab5db 655 Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain 25 224 1.8E-31 T 09-03-2017 IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain GO:0030976 TK78_RS23945 59760dcdd67884398ccd159d234ab5db 655 SUPERFAMILY SSF52518 422 643 1.25E-45 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS23945 59760dcdd67884398ccd159d234ab5db 655 SUPERFAMILY SSF52518 19 235 1.75E-29 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS23945 59760dcdd67884398ccd159d234ab5db 655 Gene3D G3DSA:3.40.50.970 415 647 1.6E-53 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS23945 59760dcdd67884398ccd159d234ab5db 655 Pfam PF00205 Thiamine pyrophosphate enzyme, central domain 244 378 3.9E-33 T 09-03-2017 IPR012000 Thiamine pyrophosphate enzyme, central domain GO:0000287|GO:0030976 TK78_RS23945 59760dcdd67884398ccd159d234ab5db 655 TIGRFAM TIGR04377 myo_inos_iolD: 3,5/4-trihydroxycyclohexa-1,2-dione hydrolase 23 652 1.9E-261 T 09-03-2017 IPR030817 3,5/4-trihydroxycyclohexa-1,2-dione hydrolase GO:0016823|GO:0019310|GO:0030976 KEGG: 00562+3.7.1.22 TK78_RS23945 59760dcdd67884398ccd159d234ab5db 655 Gene3D G3DSA:3.40.50.1220 237 387 1.8E-42 T 09-03-2017 IPR029035 DHS-like NAD/FAD-binding domain TK78_RS23945 59760dcdd67884398ccd159d234ab5db 655 Gene3D G3DSA:3.40.50.970 19 236 4.0E-62 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS29670 6f12b8d9facd9c3ac4a7792951a8ae0c 439 Pfam PF01420 Type I restriction modification DNA specificity domain 48 178 6.9E-9 T 09-03-2017 IPR000055 Restriction endonuclease, type I, HsdS GO:0003677|GO:0006304 TK78_RS29670 6f12b8d9facd9c3ac4a7792951a8ae0c 439 SUPERFAMILY SSF116734 220 429 9.16E-23 T 09-03-2017 TK78_RS29670 6f12b8d9facd9c3ac4a7792951a8ae0c 439 SUPERFAMILY SSF116734 9 216 3.11E-28 T 09-03-2017 TK78_RS08940 0f1376f89f97e7401929b5f7787ffb36 330 SMART SM00382 33 231 3.7E-15 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS08940 0f1376f89f97e7401929b5f7787ffb36 330 SUPERFAMILY SSF52540 33 307 7.82E-62 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08940 0f1376f89f97e7401929b5f7787ffb36 330 ProSitePatterns PS00211 ABC transporters family signature. 155 169 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS08940 0f1376f89f97e7401929b5f7787ffb36 330 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 233 319 2.7E-19 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS08940 0f1376f89f97e7401929b5f7787ffb36 330 Pfam PF00005 ABC transporter 25 182 6.3E-25 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS08940 0f1376f89f97e7401929b5f7787ffb36 330 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 234 299 3.9E-14 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS08940 0f1376f89f97e7401929b5f7787ffb36 330 Gene3D G3DSA:3.40.50.300 2 256 4.6E-70 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17595 a093238a8b248eddc9e361b49c7b230b 96 TIGRFAM TIGR02157 PA_CoA_Oxy2: phenylacetate-CoA oxygenase, PaaH subunit 7 95 2.9E-43 T 09-03-2017 IPR009359 Phenylacetic acid degradation B TK78_RS17595 a093238a8b248eddc9e361b49c7b230b 96 PIRSF PIRSF030200 1 96 6.5E-44 T 09-03-2017 IPR009359 Phenylacetic acid degradation B TK78_RS17595 a093238a8b248eddc9e361b49c7b230b 96 Pfam PF06243 Phenylacetic acid degradation B 6 93 2.0E-40 T 09-03-2017 IPR009359 Phenylacetic acid degradation B TK78_RS04615 034f893c4786a5daf2bb641ee144500d 527 PRINTS PR00407 Eukaryotic molybdopterin domain signature 350 366 6.9E-5 T 09-03-2017 IPR008335 Eukaryotic molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-1614517 TK78_RS04615 034f893c4786a5daf2bb641ee144500d 527 PRINTS PR00407 Eukaryotic molybdopterin domain signature 367 380 6.9E-5 T 09-03-2017 IPR008335 Eukaryotic molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-1614517 TK78_RS04615 034f893c4786a5daf2bb641ee144500d 527 PRINTS PR00407 Eukaryotic molybdopterin domain signature 299 314 6.9E-5 T 09-03-2017 IPR008335 Eukaryotic molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-1614517 TK78_RS04615 034f893c4786a5daf2bb641ee144500d 527 SUPERFAMILY SSF56524 230 424 1.57E-52 T 09-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 TK78_RS04615 034f893c4786a5daf2bb641ee144500d 527 Gene3D G3DSA:3.90.420.10 220 421 5.6E-51 T 09-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 TK78_RS04615 034f893c4786a5daf2bb641ee144500d 527 Gene3D G3DSA:2.60.40.650 422 525 3.2E-22 T 09-03-2017 IPR005066 Moybdenum cofactor oxidoreductase, dimerisation GO:0016491|GO:0030151|GO:0055114 Reactome: R-HSA-1614517 TK78_RS04615 034f893c4786a5daf2bb641ee144500d 527 Pfam PF00174 Oxidoreductase molybdopterin binding domain 248 400 5.3E-35 T 09-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 TK78_RS04615 034f893c4786a5daf2bb641ee144500d 527 SUPERFAMILY SSF81296 417 526 4.62E-25 T 09-03-2017 IPR014756 Immunoglobulin E-set TK78_RS17275 1f8ae4d9dcdb8914e185eb4bc06de48f 422 Gene3D G3DSA:1.20.1250.20 17 199 1.7E-8 T 09-03-2017 TK78_RS17275 1f8ae4d9dcdb8914e185eb4bc06de48f 422 Gene3D G3DSA:1.20.1250.20 241 416 3.1E-8 T 09-03-2017 TK78_RS17275 1f8ae4d9dcdb8914e185eb4bc06de48f 422 SUPERFAMILY SSF103473 14 418 2.75E-26 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS11270 f5da5d53bd1d0b94aed5dba6b4fce5c4 473 Pfam PF00704 Glycosyl hydrolases family 18 51 456 7.9E-82 T 09-03-2017 IPR001223 Glycoside hydrolase family 18, catalytic domain GO:0004553|GO:0005975 TK78_RS11270 f5da5d53bd1d0b94aed5dba6b4fce5c4 473 SUPERFAMILY SSF51445 47 358 2.32E-87 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS11270 f5da5d53bd1d0b94aed5dba6b4fce5c4 473 SUPERFAMILY SSF51445 426 460 2.32E-87 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS11270 f5da5d53bd1d0b94aed5dba6b4fce5c4 473 SUPERFAMILY SSF54556 360 428 8.09E-12 T 09-03-2017 IPR029070 Chitinase insertion domain TK78_RS11270 f5da5d53bd1d0b94aed5dba6b4fce5c4 473 ProSitePatterns PS01095 Chitinases family 18 active site. 205 213 - T 09-03-2017 IPR001579 Glycoside hydrolase, chitinase active site GO:0004553|GO:0005975 KEGG: 00520+3.2.1.14|MetaCyc: PWY-6902 TK78_RS11270 f5da5d53bd1d0b94aed5dba6b4fce5c4 473 SMART SM00636 49 456 8.4E-116 T 09-03-2017 IPR011583 Chitinase II GO:0004568|GO:0006032 TK78_RS11270 f5da5d53bd1d0b94aed5dba6b4fce5c4 473 Gene3D G3DSA:3.20.20.80 45 361 6.0E-101 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS11270 f5da5d53bd1d0b94aed5dba6b4fce5c4 473 Gene3D G3DSA:3.20.20.80 433 470 6.0E-101 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS11270 f5da5d53bd1d0b94aed5dba6b4fce5c4 473 Gene3D G3DSA:3.10.50.10 362 428 2.1E-21 T 09-03-2017 IPR029070 Chitinase insertion domain TK78_RS31845 eecb2dc7efcdd1ac973bdfcfea95cc3e 114 Pfam PF11042 Protein of unknown function (DUF2750) 9 110 8.8E-16 T 09-03-2017 IPR021284 Protein of unknown function DUF2750 TK78_RS21940 1f08210db800f97f2471a4e667118feb 496 SUPERFAMILY SSF55846 301 488 5.04E-48 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS21940 1f08210db800f97f2471a4e667118feb 496 SMART SM00701 301 449 2.3E-53 T 09-03-2017 IPR006619 Peptidoglycan recognition protein family domain, metazoa/bacteria GO:0008270|GO:0008745|GO:0009253 TK78_RS21940 1f08210db800f97f2471a4e667118feb 496 Pfam PF01510 N-acetylmuramoyl-L-alanine amidase 324 476 5.4E-11 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS21940 1f08210db800f97f2471a4e667118feb 496 Gene3D G3DSA:3.40.80.10 298 492 9.4E-51 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS15080 d5bcf0ca1fb8322d9043106cd0b95f83 499 Gene3D G3DSA:3.40.50.980 8 162 4.3E-33 T 09-03-2017 TK78_RS15080 d5bcf0ca1fb8322d9043106cd0b95f83 499 Gene3D G3DSA:3.40.50.980 163 316 2.7E-28 T 09-03-2017 TK78_RS15080 d5bcf0ca1fb8322d9043106cd0b95f83 499 Gene3D G3DSA:2.30.38.10 321 398 2.0E-22 T 09-03-2017 TK78_RS15080 d5bcf0ca1fb8322d9043106cd0b95f83 499 SUPERFAMILY SSF56801 7 496 3.79E-119 T 09-03-2017 TK78_RS15080 d5bcf0ca1fb8322d9043106cd0b95f83 499 Gene3D G3DSA:3.30.300.30 403 497 4.4E-13 T 09-03-2017 TK78_RS15080 d5bcf0ca1fb8322d9043106cd0b95f83 499 Pfam PF00501 AMP-binding enzyme 14 409 2.8E-86 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS01570 b046e94e97b62ca98bc00c3efdff3070 277 SUPERFAMILY SSF51430 9 271 1.44E-96 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS01570 b046e94e97b62ca98bc00c3efdff3070 277 ProSitePatterns PS00798 Aldo/keto reductase family signature 1. 44 61 - T 09-03-2017 IPR018170 Aldo/keto reductase, conserved site GO:0016491|GO:0055114 TK78_RS01570 b046e94e97b62ca98bc00c3efdff3070 277 Gene3D G3DSA:3.20.20.100 8 274 4.2E-106 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS01570 b046e94e97b62ca98bc00c3efdff3070 277 PRINTS PR00069 Aldo-keto reductase signature 96 114 1.7E-47 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS01570 b046e94e97b62ca98bc00c3efdff3070 277 PRINTS PR00069 Aldo-keto reductase signature 162 191 1.7E-47 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS01570 b046e94e97b62ca98bc00c3efdff3070 277 PRINTS PR00069 Aldo-keto reductase signature 40 64 1.7E-47 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS01570 b046e94e97b62ca98bc00c3efdff3070 277 PRINTS PR00069 Aldo-keto reductase signature 199 223 1.7E-47 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS01570 b046e94e97b62ca98bc00c3efdff3070 277 PRINTS PR00069 Aldo-keto reductase signature 128 145 1.7E-47 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS01570 b046e94e97b62ca98bc00c3efdff3070 277 Pfam PF00248 Aldo/keto reductase family 27 263 3.7E-52 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS01570 b046e94e97b62ca98bc00c3efdff3070 277 ProSitePatterns PS00063 Aldo/keto reductase family putative active site signature. 232 247 - T 09-03-2017 IPR018170 Aldo/keto reductase, conserved site GO:0016491|GO:0055114 TK78_RS08475 5275a0b563731015ee6f3b4099aed7d9 527 Gene3D G3DSA:3.90.226.10 266 526 4.8E-103 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS08475 5275a0b563731015ee6f3b4099aed7d9 527 Pfam PF01039 Carboxyl transferase domain 40 524 2.9E-198 T 09-03-2017 IPR000022 Carboxyl transferase KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TK78_RS08475 5275a0b563731015ee6f3b4099aed7d9 527 SUPERFAMILY SSF52096 265 527 2.38E-90 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS08475 5275a0b563731015ee6f3b4099aed7d9 527 Gene3D G3DSA:3.90.226.10 24 265 2.2E-74 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS08475 5275a0b563731015ee6f3b4099aed7d9 527 SUPERFAMILY SSF52096 14 267 6.63E-73 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS30920 35846fc4f1c33b620f40537de4257308 173 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 27 52 0.0024 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS30920 35846fc4f1c33b620f40537de4257308 173 SUPERFAMILY SSF81923 15 55 1.57E-5 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS30920 35846fc4f1c33b620f40537de4257308 173 Gene3D G3DSA:1.10.1780.10 15 156 1.2E-13 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS00700 25df21f455a2e64fca2b9a90aed49a93 267 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 74 257 2.5E-12 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS00700 25df21f455a2e64fca2b9a90aed49a93 267 SUPERFAMILY SSF161098 29 255 1.31E-43 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS00700 25df21f455a2e64fca2b9a90aed49a93 267 Gene3D G3DSA:1.10.3720.10 36 264 1.7E-43 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS03560 c01d7c8fc4a52cfb9182d92c5ad63917 696 PRINTS PR01036 Tetracycline resistance protein TetB signature 373 393 3.1E-9 T 09-03-2017 TK78_RS03560 c01d7c8fc4a52cfb9182d92c5ad63917 696 PRINTS PR01036 Tetracycline resistance protein TetB signature 121 141 3.1E-9 T 09-03-2017 TK78_RS03560 c01d7c8fc4a52cfb9182d92c5ad63917 696 PRINTS PR01036 Tetracycline resistance protein TetB signature 151 175 3.1E-9 T 09-03-2017 TK78_RS03560 c01d7c8fc4a52cfb9182d92c5ad63917 696 PRINTS PR01036 Tetracycline resistance protein TetB signature 31 55 3.1E-9 T 09-03-2017 TK78_RS03560 c01d7c8fc4a52cfb9182d92c5ad63917 696 PRINTS PR01036 Tetracycline resistance protein TetB signature 216 234 3.1E-9 T 09-03-2017 TK78_RS03560 c01d7c8fc4a52cfb9182d92c5ad63917 696 PRINTS PR01036 Tetracycline resistance protein TetB signature 415 434 3.1E-9 T 09-03-2017 TK78_RS03560 c01d7c8fc4a52cfb9182d92c5ad63917 696 Gene3D G3DSA:1.20.1250.20 267 435 5.0E-23 T 09-03-2017 TK78_RS03560 c01d7c8fc4a52cfb9182d92c5ad63917 696 Gene3D G3DSA:1.20.1250.20 24 201 2.1E-31 T 09-03-2017 TK78_RS03560 c01d7c8fc4a52cfb9182d92c5ad63917 696 Gene3D G3DSA:1.20.1250.20 485 516 5.0E-23 T 09-03-2017 TK78_RS03560 c01d7c8fc4a52cfb9182d92c5ad63917 696 Pfam PF07690 Major Facilitator Superfamily 33 424 3.4E-48 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS03560 c01d7c8fc4a52cfb9182d92c5ad63917 696 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 28 506 1.1E-79 T 09-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 TK78_RS03560 c01d7c8fc4a52cfb9182d92c5ad63917 696 SUPERFAMILY SSF103473 262 434 4.58E-72 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS03560 c01d7c8fc4a52cfb9182d92c5ad63917 696 SUPERFAMILY SSF103473 483 510 4.58E-72 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS03560 c01d7c8fc4a52cfb9182d92c5ad63917 696 SUPERFAMILY SSF103473 14 210 4.58E-72 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS10210 0a33869ca1109408be41a42e99912a33 468 SUPERFAMILY SSF51206 100 219 3.27E-22 T 09-03-2017 IPR018490 Cyclic nucleotide-binding-like TK78_RS10210 0a33869ca1109408be41a42e99912a33 468 Pfam PF00027 Cyclic nucleotide-binding domain 114 200 1.8E-16 T 09-03-2017 IPR000595 Cyclic nucleotide-binding domain TK78_RS10210 0a33869ca1109408be41a42e99912a33 468 SMART SM00100 94 217 2.0E-9 T 09-03-2017 IPR000595 Cyclic nucleotide-binding domain TK78_RS10210 0a33869ca1109408be41a42e99912a33 468 Gene3D G3DSA:2.60.120.10 89 215 4.7E-21 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS18965 044b599c2deca1495bb1a605ebad5f20 362 Pfam PF00877 NlpC/P60 family 261 343 1.2E-17 T 09-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain TK78_RS18965 044b599c2deca1495bb1a605ebad5f20 362 Gene3D G3DSA:3.90.1720.10 243 350 1.1E-34 T 09-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain TK78_RS18965 044b599c2deca1495bb1a605ebad5f20 362 SUPERFAMILY SSF54001 246 359 3.78E-32 T 09-03-2017 TK78_RS10175 058403159d44941704ec2db41f0606c1 317 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 6 64 1.8E-17 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS10175 058403159d44941704ec2db41f0606c1 317 Gene3D G3DSA:3.40.190.10 190 266 1.1E-5 T 09-03-2017 TK78_RS10175 058403159d44941704ec2db41f0606c1 317 Gene3D G3DSA:1.10.10.10 2 81 1.4E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS10175 058403159d44941704ec2db41f0606c1 317 SUPERFAMILY SSF53850 95 299 3.1E-17 T 09-03-2017 TK78_RS10175 058403159d44941704ec2db41f0606c1 317 Pfam PF03466 LysR substrate binding domain 95 292 2.1E-19 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS10175 058403159d44941704ec2db41f0606c1 317 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 31 41 3.3E-7 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS10175 058403159d44941704ec2db41f0606c1 317 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 20 31 3.3E-7 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS10175 058403159d44941704ec2db41f0606c1 317 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 41 52 3.3E-7 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS10175 058403159d44941704ec2db41f0606c1 317 SUPERFAMILY SSF46785 3 103 1.04E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS10175 058403159d44941704ec2db41f0606c1 317 Gene3D G3DSA:3.40.190.10 89 189 1.3E-12 T 09-03-2017 TK78_RS18105 7e864b6791de7a657d770a44370fe427 88 Gene3D G3DSA:1.10.340.20 9 86 3.2E-5 T 09-03-2017 IPR023162 Apc36109-like domain TK78_RS18105 7e864b6791de7a657d770a44370fe427 88 SUPERFAMILY SSF116922 11 84 1.31E-5 T 09-03-2017 IPR023162 Apc36109-like domain TK78_RS22490 3608e9c074e589f3312f22487cc7301b 442 Gene3D G3DSA:1.20.1250.20 220 399 3.5E-20 T 09-03-2017 TK78_RS22490 3608e9c074e589f3312f22487cc7301b 442 Gene3D G3DSA:1.20.1250.20 8 188 2.0E-15 T 09-03-2017 TK78_RS22490 3608e9c074e589f3312f22487cc7301b 442 Pfam PF05977 Transmembrane secretion effector 12 408 5.0E-22 T 09-03-2017 IPR010290 Transmembrane secretion effector TK78_RS22490 3608e9c074e589f3312f22487cc7301b 442 SUPERFAMILY SSF103473 5 400 2.49E-45 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS20785 d5a08484c53d0be64ff66d2d9783d684 170 PRINTS PR00598 Bacterial regulatory protein MarR family signature 83 98 2.0E-9 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS20785 d5a08484c53d0be64ff66d2d9783d684 170 PRINTS PR00598 Bacterial regulatory protein MarR family signature 66 82 2.0E-9 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS20785 d5a08484c53d0be64ff66d2d9783d684 170 PRINTS PR00598 Bacterial regulatory protein MarR family signature 133 153 2.0E-9 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS20785 d5a08484c53d0be64ff66d2d9783d684 170 PRINTS PR00598 Bacterial regulatory protein MarR family signature 102 118 2.0E-9 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS20785 d5a08484c53d0be64ff66d2d9783d684 170 SMART SM00347 40 143 3.0E-14 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS20785 d5a08484c53d0be64ff66d2d9783d684 170 Gene3D G3DSA:1.10.10.10 8 159 2.0E-36 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS20785 d5a08484c53d0be64ff66d2d9783d684 170 Pfam PF12802 MarR family 46 106 1.2E-12 T 09-03-2017 TK78_RS20785 d5a08484c53d0be64ff66d2d9783d684 170 SUPERFAMILY SSF46785 11 158 1.25E-27 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS31410 5e7d01f52ccfd4c850b177f34e7c1939 1014 Pfam PF13558 Putative exonuclease SbcCD, C subunit 908 972 3.9E-13 T 09-03-2017 TK78_RS31410 5e7d01f52ccfd4c850b177f34e7c1939 1014 SUPERFAMILY SSF52540 2 224 4.74E-32 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31410 5e7d01f52ccfd4c850b177f34e7c1939 1014 SUPERFAMILY SSF52540 861 1008 4.74E-32 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31410 5e7d01f52ccfd4c850b177f34e7c1939 1014 Pfam PF13476 AAA domain 5 211 4.0E-23 T 09-03-2017 TK78_RS31410 5e7d01f52ccfd4c850b177f34e7c1939 1014 Gene3D G3DSA:3.40.50.300 872 1009 1.8E-33 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31410 5e7d01f52ccfd4c850b177f34e7c1939 1014 Gene3D G3DSA:3.40.50.300 2 180 1.8E-33 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31410 5e7d01f52ccfd4c850b177f34e7c1939 1014 Gene3D G3DSA:3.40.50.300 484 485 1.8E-33 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33780 2c70faf6694985648a864c571eff42d8 478 Gene3D G3DSA:1.50.10.20 151 342 2.4E-18 T 09-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid TK78_RS33780 2c70faf6694985648a864c571eff42d8 478 SUPERFAMILY SSF48239 160 365 7.69E-16 T 09-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid TK78_RS33780 2c70faf6694985648a864c571eff42d8 478 SUPERFAMILY SSF48239 29 214 1.74E-7 T 09-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid TK78_RS11035 a8cfaeb85de8d8ca6b56975a74c5c1bb 292 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 106 286 2.3E-26 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS11035 a8cfaeb85de8d8ca6b56975a74c5c1bb 292 SUPERFAMILY SSF161098 20 292 3.64E-74 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS11035 a8cfaeb85de8d8ca6b56975a74c5c1bb 292 Gene3D G3DSA:1.10.3720.10 18 280 7.5E-71 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS22505 b0671e8634a70abcbc4a2ac4aeb0a3db 321 Pfam PF04069 Substrate binding domain of ABC-type glycine betaine transport system 45 313 2.8E-58 T 09-03-2017 IPR007210 ABC-type glycine betaine transport system, substrate-binding domain GO:0005215|GO:0006810 TK78_RS22505 b0671e8634a70abcbc4a2ac4aeb0a3db 321 Gene3D G3DSA:3.40.190.120 148 256 1.4E-32 T 09-03-2017 TK78_RS22505 b0671e8634a70abcbc4a2ac4aeb0a3db 321 Gene3D G3DSA:3.40.190.10 43 147 1.2E-51 T 09-03-2017 TK78_RS22505 b0671e8634a70abcbc4a2ac4aeb0a3db 321 Gene3D G3DSA:3.40.190.10 262 318 1.2E-51 T 09-03-2017 TK78_RS22505 b0671e8634a70abcbc4a2ac4aeb0a3db 321 SUPERFAMILY SSF53850 45 317 3.53E-59 T 09-03-2017 TK78_RS12675 ec0d6d9f6fb2cc1531f3e5321141def9 564 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 23 46 - T 09-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 TK78_RS12675 ec0d6d9f6fb2cc1531f3e5321141def9 564 Pfam PF00069 Protein kinase domain 17 267 1.6E-45 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS12675 ec0d6d9f6fb2cc1531f3e5321141def9 564 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 140 152 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS12675 ec0d6d9f6fb2cc1531f3e5321141def9 564 Gene3D G3DSA:3.30.200.20 10 86 4.1E-23 T 09-03-2017 TK78_RS12675 ec0d6d9f6fb2cc1531f3e5321141def9 564 SMART SM00220 17 275 1.7E-59 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS12675 ec0d6d9f6fb2cc1531f3e5321141def9 564 Gene3D G3DSA:1.10.510.10 87 269 8.0E-47 T 09-03-2017 TK78_RS12675 ec0d6d9f6fb2cc1531f3e5321141def9 564 SUPERFAMILY SSF56112 13 269 1.11E-66 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS04515 3aadb7566ce72b3267166777a573291c 122 Pfam PF12172 Rubredoxin-like zinc ribbon domain (DUF35_N) 10 40 2.6E-5 T 09-03-2017 IPR022002 Domain of unknown function DUF35, rubredoxin-like zinc ribbon domain, N-terminal TK78_RS04515 3aadb7566ce72b3267166777a573291c 122 SUPERFAMILY SSF50249 9 104 9.77E-10 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS09285 34700d116e6a3129a86109996cacd690 608 SMART SM00382 364 549 2.6E-12 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS09285 34700d116e6a3129a86109996cacd690 608 SUPERFAMILY SSF52540 333 570 2.27E-73 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09285 34700d116e6a3129a86109996cacd690 608 Pfam PF00664 ABC transporter transmembrane region 22 289 1.1E-41 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS09285 34700d116e6a3129a86109996cacd690 608 Gene3D G3DSA:3.40.50.300 336 566 7.2E-71 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09285 34700d116e6a3129a86109996cacd690 608 Pfam PF00005 ABC transporter 355 502 1.8E-29 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS09285 34700d116e6a3129a86109996cacd690 608 ProSitePatterns PS00211 ABC transporters family signature. 475 489 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS09285 34700d116e6a3129a86109996cacd690 608 SUPERFAMILY SSF90123 6 317 2.22E-68 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS09285 34700d116e6a3129a86109996cacd690 608 Gene3D G3DSA:1.20.1560.10 6 316 2.8E-65 T 09-03-2017 TK78_RS14795 d38ac1f5a39622a4cdec986f45019915 427 Pfam PF07690 Major Facilitator Superfamily 19 341 8.5E-43 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS14795 d38ac1f5a39622a4cdec986f45019915 427 SUPERFAMILY SSF103473 5 390 1.06E-60 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS14795 d38ac1f5a39622a4cdec986f45019915 427 Gene3D G3DSA:1.20.1250.20 15 200 3.2E-30 T 09-03-2017 TK78_RS14795 d38ac1f5a39622a4cdec986f45019915 427 Gene3D G3DSA:1.20.1250.20 201 389 5.6E-16 T 09-03-2017 TK78_RS16070 9387ff895dc99035dea9d7885fe3a2f1 337 Pfam PF00196 Bacterial regulatory proteins, luxR family 265 311 1.0E-6 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS16070 9387ff895dc99035dea9d7885fe3a2f1 337 SUPERFAMILY SSF46894 250 321 1.26E-10 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS16070 9387ff895dc99035dea9d7885fe3a2f1 337 Gene3D G3DSA:1.10.10.10 258 320 1.7E-11 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS16070 9387ff895dc99035dea9d7885fe3a2f1 337 SMART SM00421 258 315 5.6E-8 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS12305 b63e9c519591c1982216687ccc2410f5 444 Pfam PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 315 418 6.3E-16 T 09-03-2017 IPR022643 Orn/DAP/Arg decarboxylase 2, C-terminal GO:0003824 TK78_RS12305 b63e9c519591c1982216687ccc2410f5 444 Gene3D G3DSA:3.20.20.10 54 297 4.7E-87 T 09-03-2017 IPR029066 PLP-binding barrel TK78_RS12305 b63e9c519591c1982216687ccc2410f5 444 Hamap MF_02120 Diaminopimelate decarboxylase [lysA]. 35 442 39.14 T 09-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS12305 b63e9c519591c1982216687ccc2410f5 444 SUPERFAMILY SSF50621 286 442 8.79E-48 T 09-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 TK78_RS12305 b63e9c519591c1982216687ccc2410f5 444 TIGRFAM TIGR01048 lysA: diaminopimelate decarboxylase 28 441 3.3E-131 T 09-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS12305 b63e9c519591c1982216687ccc2410f5 444 ProSitePatterns PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. 75 93 - T 09-03-2017 IPR022653 Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site TK78_RS12305 b63e9c519591c1982216687ccc2410f5 444 PRINTS PR01181 Diaminopimelate decarboxylase signature 326 344 7.7E-24 T 09-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS12305 b63e9c519591c1982216687ccc2410f5 444 PRINTS PR01181 Diaminopimelate decarboxylase signature 93 110 7.7E-24 T 09-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS12305 b63e9c519591c1982216687ccc2410f5 444 PRINTS PR01181 Diaminopimelate decarboxylase signature 409 431 7.7E-24 T 09-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS12305 b63e9c519591c1982216687ccc2410f5 444 PRINTS PR01181 Diaminopimelate decarboxylase signature 181 190 7.7E-24 T 09-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS12305 b63e9c519591c1982216687ccc2410f5 444 Gene3D G3DSA:2.40.37.10 298 442 6.6E-46 T 09-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 TK78_RS12305 b63e9c519591c1982216687ccc2410f5 444 Pfam PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 55 308 1.5E-57 T 09-03-2017 IPR022644 Orn/DAP/Arg decarboxylase 2, N-terminal GO:0003824 TK78_RS12305 b63e9c519591c1982216687ccc2410f5 444 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 95 107 1.8E-20 T 09-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TK78_RS12305 b63e9c519591c1982216687ccc2410f5 444 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 399 412 1.8E-20 T 09-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TK78_RS12305 b63e9c519591c1982216687ccc2410f5 444 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 75 93 1.8E-20 T 09-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TK78_RS12305 b63e9c519591c1982216687ccc2410f5 444 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 209 222 1.8E-20 T 09-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TK78_RS12305 b63e9c519591c1982216687ccc2410f5 444 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 298 317 1.8E-20 T 09-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TK78_RS12305 b63e9c519591c1982216687ccc2410f5 444 SUPERFAMILY SSF51419 46 310 4.8E-75 T 09-03-2017 IPR029066 PLP-binding barrel TK78_RS04390 070b3758fa2af11e3440736d6ad25de0 175 ProSitePatterns PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 134 140 - T 09-03-2017 IPR001497 Methylated-DNA-[protein]-cysteine S-methyltransferase, active site GO:0003908|GO:0006281 Reactome: R-HSA-5657655 TK78_RS04390 070b3758fa2af11e3440736d6ad25de0 175 Hamap MF_00772 Methylated-DNA--protein-cysteine methyltransferase [ogt]. 11 167 39.518 T 09-03-2017 IPR023546 Methylated-DNA--protein-cysteine methyltransferase GO:0003824|GO:0006281 TK78_RS04390 070b3758fa2af11e3440736d6ad25de0 175 SUPERFAMILY SSF46767 83 163 8.63E-32 T 09-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 TK78_RS04390 070b3758fa2af11e3440736d6ad25de0 175 SUPERFAMILY SSF53155 13 88 5.89E-19 T 09-03-2017 IPR008332 Methylguanine DNA methyltransferase, ribonuclease-like domain GO:0003908|GO:0006281 Reactome: R-HSA-5657655 TK78_RS04390 070b3758fa2af11e3440736d6ad25de0 175 Pfam PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 14 79 6.9E-6 T 09-03-2017 IPR008332 Methylguanine DNA methyltransferase, ribonuclease-like domain GO:0003908|GO:0006281 Reactome: R-HSA-5657655 TK78_RS04390 070b3758fa2af11e3440736d6ad25de0 175 Pfam PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 85 163 2.1E-32 T 09-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 TK78_RS04390 070b3758fa2af11e3440736d6ad25de0 175 Gene3D G3DSA:1.10.10.10 83 164 1.1E-34 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS04390 070b3758fa2af11e3440736d6ad25de0 175 TIGRFAM TIGR00589 ogt: methylated-DNA--[protein]-cysteine S-methyltransferase 84 163 1.4E-34 T 09-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 TK78_RS18255 d7ffe94dd833e3c636f5af01dcb847a3 281 Pfam PF01551 Peptidase family M23 179 243 2.5E-17 T 09-03-2017 IPR016047 Peptidase M23 TK78_RS18255 d7ffe94dd833e3c636f5af01dcb847a3 281 Gene3D G3DSA:2.70.70.10 66 245 3.9E-27 T 09-03-2017 TK78_RS18255 d7ffe94dd833e3c636f5af01dcb847a3 281 SUPERFAMILY SSF51261 118 150 2.93E-23 T 09-03-2017 IPR011055 Duplicated hybrid motif TK78_RS18255 d7ffe94dd833e3c636f5af01dcb847a3 281 SUPERFAMILY SSF51261 181 245 2.93E-23 T 09-03-2017 IPR011055 Duplicated hybrid motif TK78_RS20630 a02756b7822da8c70cead18c12939e2c 260 SUPERFAMILY SSF51735 5 259 1.46E-64 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS20630 a02756b7822da8c70cead18c12939e2c 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 221 241 1.9E-21 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20630 a02756b7822da8c70cead18c12939e2c 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 7 24 1.9E-21 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20630 a02756b7822da8c70cead18c12939e2c 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 156 175 1.9E-21 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20630 a02756b7822da8c70cead18c12939e2c 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 177 194 1.9E-21 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20630 a02756b7822da8c70cead18c12939e2c 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 81 92 1.9E-21 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20630 a02756b7822da8c70cead18c12939e2c 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 128 144 1.9E-21 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20630 a02756b7822da8c70cead18c12939e2c 260 Gene3D G3DSA:3.40.50.720 3 257 1.1E-62 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS20630 a02756b7822da8c70cead18c12939e2c 260 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 12 256 6.1E-49 T 09-03-2017 TK78_RS02680 529830a25461b258651ff3e119e60e49 175 Pfam PF07681 DoxX 10 95 2.9E-15 T 09-03-2017 IPR032808 DoxX family TK78_RS03735 cfe83b3ba05cc2503c95a25fcbf3c5e6 417 Gene3D G3DSA:1.10.630.10 22 415 1.5E-102 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS03735 cfe83b3ba05cc2503c95a25fcbf3c5e6 417 PRINTS PR00359 B-class P450 signature 152 168 1.8E-31 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS03735 cfe83b3ba05cc2503c95a25fcbf3c5e6 417 PRINTS PR00359 B-class P450 signature 287 298 1.8E-31 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS03735 cfe83b3ba05cc2503c95a25fcbf3c5e6 417 PRINTS PR00359 B-class P450 signature 305 332 1.8E-31 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS03735 cfe83b3ba05cc2503c95a25fcbf3c5e6 417 PRINTS PR00359 B-class P450 signature 102 113 1.8E-31 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS03735 cfe83b3ba05cc2503c95a25fcbf3c5e6 417 PRINTS PR00359 B-class P450 signature 169 184 1.8E-31 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS03735 cfe83b3ba05cc2503c95a25fcbf3c5e6 417 PRINTS PR00359 B-class P450 signature 356 365 1.8E-31 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS03735 cfe83b3ba05cc2503c95a25fcbf3c5e6 417 PRINTS PR00359 B-class P450 signature 206 228 1.8E-31 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS03735 cfe83b3ba05cc2503c95a25fcbf3c5e6 417 PRINTS PR00359 B-class P450 signature 365 376 1.8E-31 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS03735 cfe83b3ba05cc2503c95a25fcbf3c5e6 417 Pfam PF00067 Cytochrome P450 286 386 1.2E-17 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS03735 cfe83b3ba05cc2503c95a25fcbf3c5e6 417 SUPERFAMILY SSF48264 33 414 1.57E-83 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS03735 cfe83b3ba05cc2503c95a25fcbf3c5e6 417 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 358 367 - T 09-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 TK78_RS31815 71b98f5cb7b4bc87ec7851bee4854f90 289 ProSitePatterns PS00211 ABC transporters family signature. 137 151 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS31815 71b98f5cb7b4bc87ec7851bee4854f90 289 SMART SM00382 47 214 2.7E-14 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS31815 71b98f5cb7b4bc87ec7851bee4854f90 289 Pfam PF00005 ABC transporter 39 164 3.7E-26 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS31815 71b98f5cb7b4bc87ec7851bee4854f90 289 SUPERFAMILY SSF52540 12 220 6.88E-60 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31815 71b98f5cb7b4bc87ec7851bee4854f90 289 Gene3D G3DSA:3.40.50.300 21 221 2.1E-61 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS02300 3a1be4bf1de53bde39b639c82d072522 250 Gene3D G3DSA:3.40.50.2300 1 131 7.0E-24 T 09-03-2017 TK78_RS02300 3a1be4bf1de53bde39b639c82d072522 250 SMART SM00850 150 245 2.9E-30 T 09-03-2017 IPR007492 LytTR DNA-binding domain GO:0003677 TK78_RS02300 3a1be4bf1de53bde39b639c82d072522 250 Gene3D G3DSA:2.40.50.40 142 209 3.3E-16 T 09-03-2017 TK78_RS02300 3a1be4bf1de53bde39b639c82d072522 250 Pfam PF04397 LytTr DNA-binding domain 152 244 1.2E-22 T 09-03-2017 IPR007492 LytTR DNA-binding domain GO:0003677 TK78_RS02300 3a1be4bf1de53bde39b639c82d072522 250 SUPERFAMILY SSF52172 1 128 1.27E-23 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS02300 3a1be4bf1de53bde39b639c82d072522 250 Pfam PF00072 Response regulator receiver domain 4 123 5.8E-15 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS02300 3a1be4bf1de53bde39b639c82d072522 250 SMART SM00448 2 122 8.7E-17 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS15280 44d07182aa9f3471496f280dbb6b10a1 401 SUPERFAMILY SSF52540 4 227 2.87E-43 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15280 44d07182aa9f3471496f280dbb6b10a1 401 Pfam PF13177 DNA polymerase III, delta subunit 41 188 9.4E-35 T 09-03-2017 TK78_RS15280 44d07182aa9f3471496f280dbb6b10a1 401 Gene3D G3DSA:3.40.50.300 4 188 9.6E-52 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27495 611212ad9bda87a0ab4aab68d11964a6 312 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 16 33 6.6E-21 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS27495 611212ad9bda87a0ab4aab68d11964a6 312 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 154 170 6.6E-21 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS27495 611212ad9bda87a0ab4aab68d11964a6 312 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 201 218 6.6E-21 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS27495 611212ad9bda87a0ab4aab68d11964a6 312 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 180 199 6.6E-21 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS27495 611212ad9bda87a0ab4aab68d11964a6 312 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 101 112 6.6E-21 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS27495 611212ad9bda87a0ab4aab68d11964a6 312 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 167 195 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS27495 611212ad9bda87a0ab4aab68d11964a6 312 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 180 199 2.5E-8 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS27495 611212ad9bda87a0ab4aab68d11964a6 312 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 160 168 2.5E-8 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS27495 611212ad9bda87a0ab4aab68d11964a6 312 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 101 112 2.5E-8 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS27495 611212ad9bda87a0ab4aab68d11964a6 312 SUPERFAMILY SSF51735 13 270 3.4E-55 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS27495 611212ad9bda87a0ab4aab68d11964a6 312 Pfam PF00106 short chain dehydrogenase 16 219 4.3E-37 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS27495 611212ad9bda87a0ab4aab68d11964a6 312 Gene3D G3DSA:3.40.50.720 11 276 7.4E-63 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS27495 611212ad9bda87a0ab4aab68d11964a6 312 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 15 211 7.3E-4 T 09-03-2017 TK78_RS23470 b73d559b2210adde66f4190b2a247fd6 540 Gene3D G3DSA:3.90.226.10 282 527 2.3E-96 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS23470 b73d559b2210adde66f4190b2a247fd6 540 Gene3D G3DSA:3.90.226.10 33 271 1.3E-79 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS23470 b73d559b2210adde66f4190b2a247fd6 540 Pfam PF01039 Carboxyl transferase domain 51 524 3.2E-151 T 09-03-2017 IPR000022 Carboxyl transferase KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TK78_RS23470 b73d559b2210adde66f4190b2a247fd6 540 SUPERFAMILY SSF52096 29 272 4.84E-74 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS23470 b73d559b2210adde66f4190b2a247fd6 540 SUPERFAMILY SSF52096 240 517 2.49E-88 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS24900 066e27561eede233a22d850fceaae068 260 SMART SM00382 37 231 1.4E-12 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS24900 066e27561eede233a22d850fceaae068 260 Pfam PF00005 ABC transporter 28 175 1.1E-26 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS24900 066e27561eede233a22d850fceaae068 260 Gene3D G3DSA:3.40.50.300 5 237 5.1E-59 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24900 066e27561eede233a22d850fceaae068 260 SUPERFAMILY SSF52540 8 240 2.07E-54 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS02530 ad98692a77d6c00e6367d2e5ca277855 366 Pfam PF04261 Dyp-type peroxidase family 47 308 1.9E-92 T 09-03-2017 IPR006314 Dyp-type peroxidase GO:0004601|GO:0020037|GO:0055114 TK78_RS02530 ad98692a77d6c00e6367d2e5ca277855 366 TIGRFAM TIGR01413 Dyp_perox_fam: Dyp-type peroxidase family 14 308 1.6E-81 T 09-03-2017 IPR006314 Dyp-type peroxidase GO:0004601|GO:0020037|GO:0055114 TK78_RS02530 ad98692a77d6c00e6367d2e5ca277855 366 SUPERFAMILY SSF54909 12 311 4.11E-104 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS29680 84eeae76d5656ee3d91f48e4120411c3 550 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 28 51 - T 09-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 TK78_RS29680 84eeae76d5656ee3d91f48e4120411c3 550 Gene3D G3DSA:3.30.200.20 16 114 9.2E-18 T 09-03-2017 TK78_RS29680 84eeae76d5656ee3d91f48e4120411c3 550 SMART SM00220 22 302 3.1E-57 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS29680 84eeae76d5656ee3d91f48e4120411c3 550 Gene3D G3DSA:1.25.40.10 368 516 1.6E-9 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS29680 84eeae76d5656ee3d91f48e4120411c3 550 SUPERFAMILY SSF56112 15 299 2.29E-65 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS29680 84eeae76d5656ee3d91f48e4120411c3 550 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 159 171 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS29680 84eeae76d5656ee3d91f48e4120411c3 550 Gene3D G3DSA:1.10.510.10 120 296 9.7E-44 T 09-03-2017 TK78_RS29680 84eeae76d5656ee3d91f48e4120411c3 550 SUPERFAMILY SSF48452 369 515 3.54E-9 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS29680 84eeae76d5656ee3d91f48e4120411c3 550 Pfam PF00069 Protein kinase domain 22 295 2.2E-39 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS03100 4f0c408ec3d0407cec19cc553c6d1756 305 SUPERFAMILY SSF102114 13 237 1.12E-16 T 09-03-2017 TK78_RS03100 4f0c408ec3d0407cec19cc553c6d1756 305 Gene3D G3DSA:3.20.20.70 13 241 7.4E-10 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS10265 c8e3d3631080c7b1630bc145f259f760 488 PRINTS PR00344 Bacterial sensor protein C-terminal signature 426 440 1.3E-5 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS10265 c8e3d3631080c7b1630bc145f259f760 488 PRINTS PR00344 Bacterial sensor protein C-terminal signature 445 463 1.3E-5 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS10265 c8e3d3631080c7b1630bc145f259f760 488 PRINTS PR00344 Bacterial sensor protein C-terminal signature 470 483 1.3E-5 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS10265 c8e3d3631080c7b1630bc145f259f760 488 Pfam PF07568 Histidine kinase 290 360 1.6E-22 T 09-03-2017 IPR011495 Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor domain TK78_RS10265 c8e3d3631080c7b1630bc145f259f760 488 SUPERFAMILY SSF55785 173 281 1.92E-5 T 09-03-2017 IPR000014 PAS domain TK78_RS10265 c8e3d3631080c7b1630bc145f259f760 488 Gene3D G3DSA:3.30.450.20 171 273 2.9E-5 T 09-03-2017 TK78_RS10265 c8e3d3631080c7b1630bc145f259f760 488 SUPERFAMILY SSF55874 345 484 7.07E-17 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS10265 c8e3d3631080c7b1630bc145f259f760 488 Pfam PF12282 Signal transduction histidine kinase 1 144 4.6E-61 T 09-03-2017 IPR022066 Signal transduction histidine kinase TK78_RS10265 c8e3d3631080c7b1630bc145f259f760 488 Gene3D G3DSA:3.30.565.10 345 485 7.6E-16 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS10265 c8e3d3631080c7b1630bc145f259f760 488 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 385 484 7.4E-11 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS10265 c8e3d3631080c7b1630bc145f259f760 488 SMART SM00387 382 486 6.4E-9 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS10265 c8e3d3631080c7b1630bc145f259f760 488 Pfam PF08448 PAS fold 171 276 4.1E-11 T 09-03-2017 IPR013656 PAS fold-4 TK78_RS34545 d72ad50a36602848886b1074e8d61561 135 Gene3D G3DSA:3.30.70.1060 1 130 8.5E-39 T 09-03-2017 TK78_RS34545 d72ad50a36602848886b1074e8d61561 135 SUPERFAMILY SSF54909 21 125 3.22E-23 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS34545 d72ad50a36602848886b1074e8d61561 135 Pfam PF03795 YCII-related domain 15 108 4.0E-12 T 09-03-2017 IPR005545 YCII-related TK78_RS23265 643d9f0e4c03ccfb78e7bfe2483e7c40 574 SUPERFAMILY SSF56801 38 551 1.7E-70 T 09-03-2017 TK78_RS23265 643d9f0e4c03ccfb78e7bfe2483e7c40 574 Gene3D G3DSA:3.40.50.980 197 360 1.2E-12 T 09-03-2017 TK78_RS23265 643d9f0e4c03ccfb78e7bfe2483e7c40 574 Gene3D G3DSA:3.30.300.30 446 553 1.5E-7 T 09-03-2017 TK78_RS23265 643d9f0e4c03ccfb78e7bfe2483e7c40 574 ProSitePatterns PS00455 Putative AMP-binding domain signature. 193 204 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS23265 643d9f0e4c03ccfb78e7bfe2483e7c40 574 Gene3D G3DSA:3.40.50.980 59 196 5.4E-14 T 09-03-2017 TK78_RS23265 643d9f0e4c03ccfb78e7bfe2483e7c40 574 Pfam PF00501 AMP-binding enzyme 59 449 1.6E-44 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS23265 643d9f0e4c03ccfb78e7bfe2483e7c40 574 Gene3D G3DSA:2.30.38.10 368 443 2.0E-16 T 09-03-2017 TK78_RS00575 2cabeaf99c856aca181dd6efbbee3fca 305 Gene3D G3DSA:3.40.50.1220 217 291 2.1E-37 T 09-03-2017 IPR029035 DHS-like NAD/FAD-binding domain TK78_RS00575 2cabeaf99c856aca181dd6efbbee3fca 305 Gene3D G3DSA:3.40.50.1220 99 136 2.1E-37 T 09-03-2017 IPR029035 DHS-like NAD/FAD-binding domain TK78_RS00575 2cabeaf99c856aca181dd6efbbee3fca 305 Gene3D G3DSA:3.40.50.1220 20 49 2.1E-37 T 09-03-2017 IPR029035 DHS-like NAD/FAD-binding domain TK78_RS00575 2cabeaf99c856aca181dd6efbbee3fca 305 Pfam PF02146 Sir2 family 39 240 1.1E-42 T 09-03-2017 IPR003000 Sirtuin family GO:0070403 TK78_RS00575 2cabeaf99c856aca181dd6efbbee3fca 305 Hamap MF_01967 NAD-dependent protein deacetylase [cobB]. 16 285 63.718 T 09-03-2017 IPR026587 Sirtuin, class II TK78_RS00575 2cabeaf99c856aca181dd6efbbee3fca 305 Gene3D G3DSA:3.30.1600.10 137 210 2.6E-19 T 09-03-2017 IPR026591 Sirtuin family, catalytic core small domain TK78_RS00575 2cabeaf99c856aca181dd6efbbee3fca 305 Gene3D G3DSA:3.30.1600.10 50 84 2.6E-19 T 09-03-2017 IPR026591 Sirtuin family, catalytic core small domain TK78_RS00575 2cabeaf99c856aca181dd6efbbee3fca 305 SUPERFAMILY SSF52467 16 289 2.66E-73 T 09-03-2017 IPR029035 DHS-like NAD/FAD-binding domain TK78_RS07130 dc78020370d508459de6e08a1a2aa7a0 445 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 64 187 2.0E-8 T 09-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 TK78_RS07130 dc78020370d508459de6e08a1a2aa7a0 445 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 222 243 - T 09-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 TK78_RS07130 dc78020370d508459de6e08a1a2aa7a0 445 Pfam PF00107 Zinc-binding dehydrogenase 233 375 3.4E-28 T 09-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 TK78_RS07130 dc78020370d508459de6e08a1a2aa7a0 445 SMART SM00829 46 412 2.8E-11 T 09-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 TK78_RS07130 dc78020370d508459de6e08a1a2aa7a0 445 Gene3D G3DSA:3.90.180.10 44 229 1.5E-35 T 09-03-2017 IPR011032 GroES-like TK78_RS07130 dc78020370d508459de6e08a1a2aa7a0 445 SUPERFAMILY SSF50129 49 227 8.52E-29 T 09-03-2017 IPR011032 GroES-like TK78_RS07130 dc78020370d508459de6e08a1a2aa7a0 445 Gene3D G3DSA:3.40.50.720 230 361 6.5E-19 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07130 dc78020370d508459de6e08a1a2aa7a0 445 TIGRFAM TIGR01751 crot-CoA-red: crotonyl-CoA carboxylase/reductase 31 425 7.4E-166 T 09-03-2017 IPR010085 Crotonyl-CoA reductase GO:0043880 KEGG: 00650+1.3.1.86 TK78_RS07130 dc78020370d508459de6e08a1a2aa7a0 445 SUPERFAMILY SSF51735 192 382 7.31E-35 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS03410 65b920eaa6e1d1dfae5c09392f11d2c9 816 Gene3D G3DSA:3.40.50.880 47 277 3.2E-25 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS03410 65b920eaa6e1d1dfae5c09392f11d2c9 816 Gene3D G3DSA:2.120.10.30 278 808 9.9E-88 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS03410 65b920eaa6e1d1dfae5c09392f11d2c9 816 Pfam PF06283 Trehalose utilisation 48 268 4.6E-70 T 09-03-2017 IPR029010 ThuA-like domain TK78_RS03410 65b920eaa6e1d1dfae5c09392f11d2c9 816 Pfam PF07995 Glucose / Sorbosone dehydrogenase 342 612 3.0E-26 T 09-03-2017 IPR012938 Glucose/Sorbosone dehydrogenase GO:0005975|GO:0016901|GO:0048038 TK78_RS03410 65b920eaa6e1d1dfae5c09392f11d2c9 816 SUPERFAMILY SSF52317 48 271 1.03E-30 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS03410 65b920eaa6e1d1dfae5c09392f11d2c9 816 SUPERFAMILY SSF50952 300 624 8.11E-18 T 09-03-2017 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 TK78_RS03410 65b920eaa6e1d1dfae5c09392f11d2c9 816 SUPERFAMILY SSF50952 689 783 8.11E-18 T 09-03-2017 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 TK78_RS19130 bd3086ba34558549918853822800c451 238 Pfam PF00483 Nucleotidyl transferase 8 233 3.4E-27 T 09-03-2017 IPR005835 Nucleotidyl transferase domain GO:0009058|GO:0016779 TK78_RS19130 bd3086ba34558549918853822800c451 238 SUPERFAMILY SSF53448 6 233 2.93E-55 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS19130 bd3086ba34558549918853822800c451 238 Gene3D G3DSA:3.90.550.10 6 234 1.1E-56 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS14255 d0939ef3afb834d9519afad8b1dea43e 989 SUPERFAMILY SSF56176 24 285 2.13E-57 T 09-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 TK78_RS14255 d0939ef3afb834d9519afad8b1dea43e 989 Gene3D G3DSA:3.30.465.10 113 285 1.7E-35 T 09-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 TK78_RS14255 d0939ef3afb834d9519afad8b1dea43e 989 Gene3D G3DSA:1.10.1060.10 569 663 9.1E-11 T 09-03-2017 TK78_RS14255 d0939ef3afb834d9519afad8b1dea43e 989 SUPERFAMILY SSF55103 261 532 5.23E-55 T 09-03-2017 IPR016164 FAD-linked oxidase-like, C-terminal GO:0003824|GO:0050660 TK78_RS14255 d0939ef3afb834d9519afad8b1dea43e 989 Pfam PF02913 FAD linked oxidases, C-terminal domain 285 531 3.9E-48 T 09-03-2017 IPR004113 FAD-linked oxidase, C-terminal GO:0003824|GO:0050660 TK78_RS14255 d0939ef3afb834d9519afad8b1dea43e 989 Pfam PF01565 FAD binding domain 58 195 1.7E-40 T 09-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 TK78_RS14255 d0939ef3afb834d9519afad8b1dea43e 989 Pfam PF13183 4Fe-4S dicluster domain 569 649 4.0E-9 T 09-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TK78_RS14255 d0939ef3afb834d9519afad8b1dea43e 989 Gene3D G3DSA:3.30.43.10 21 108 3.9E-19 T 09-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 TK78_RS14255 d0939ef3afb834d9519afad8b1dea43e 989 SUPERFAMILY SSF46548 569 654 3.4E-7 T 09-03-2017 IPR009051 Alpha-helical ferredoxin GO:0051536 TK78_RS27555 d2596f0f1d3d74438b88468cbb0c8b1a 591 PRINTS PR00173 Glutamate-aspartate symporter signature 374 394 8.2E-5 T 09-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 TK78_RS27555 d2596f0f1d3d74438b88468cbb0c8b1a 591 PRINTS PR00173 Glutamate-aspartate symporter signature 21 41 8.2E-5 T 09-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 TK78_RS27555 d2596f0f1d3d74438b88468cbb0c8b1a 591 PRINTS PR00173 Glutamate-aspartate symporter signature 113 138 8.2E-5 T 09-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 TK78_RS27555 d2596f0f1d3d74438b88468cbb0c8b1a 591 Pfam PF00916 Sulfate permease family 20 379 4.8E-65 T 09-03-2017 IPR011547 SLC26A/SulP transporter domain GO:0008272|GO:0015116|GO:0016021 TK78_RS27555 d2596f0f1d3d74438b88468cbb0c8b1a 591 Pfam PF01740 STAS domain 458 550 3.7E-7 T 09-03-2017 IPR002645 STAS domain TK78_RS27555 d2596f0f1d3d74438b88468cbb0c8b1a 591 Gene3D G3DSA:3.30.750.24 457 546 7.2E-10 T 09-03-2017 IPR002645 STAS domain TK78_RS27555 d2596f0f1d3d74438b88468cbb0c8b1a 591 SUPERFAMILY SSF52091 458 556 9.61E-12 T 09-03-2017 IPR002645 STAS domain TK78_RS20385 a1cec382302723fc3bbac1f09c36a88a 163 SUPERFAMILY SSF55486 56 138 8.35E-8 T 09-03-2017 TK78_RS20385 a1cec382302723fc3bbac1f09c36a88a 163 Gene3D G3DSA:3.40.390.10 33 163 9.6E-7 T 09-03-2017 IPR024079 Metallopeptidase, catalytic domain GO:0008237 TK78_RS25320 35cb3ef9ebe5545ca21f284eeab18957 254 TIGRFAM TIGR01907 casE_Cse3: CRISPR-associated protein Cas6/Cse3/CasE, subtype I-E/ECOLI 6 250 5.5E-20 T 09-03-2017 IPR010179 CRISPR-associated protein Cse3 TK78_RS25320 35cb3ef9ebe5545ca21f284eeab18957 254 Gene3D G3DSA:3.30.70.1210 98 249 6.5E-33 T 09-03-2017 TK78_RS25320 35cb3ef9ebe5545ca21f284eeab18957 254 SUPERFAMILY SSF117987 98 249 9.68E-29 T 09-03-2017 TK78_RS25320 35cb3ef9ebe5545ca21f284eeab18957 254 Gene3D G3DSA:3.30.70.1200 5 83 4.7E-23 T 09-03-2017 TK78_RS25320 35cb3ef9ebe5545ca21f284eeab18957 254 Pfam PF08798 CRISPR associated protein 6 249 5.6E-63 T 09-03-2017 IPR010179 CRISPR-associated protein Cse3 TK78_RS25320 35cb3ef9ebe5545ca21f284eeab18957 254 SUPERFAMILY SSF117987 6 83 3.4E-21 T 09-03-2017 TK78_RS25320 35cb3ef9ebe5545ca21f284eeab18957 254 SMART SM01101 5 249 4.7E-65 T 09-03-2017 IPR010179 CRISPR-associated protein Cse3 TK78_RS18425 8291be0416c4a1df5498393997291d31 396 SMART SM00331 151 372 9.9E-24 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS18425 8291be0416c4a1df5498393997291d31 396 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 179 372 3.1E-37 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS31440 6587b5387c85cce07163c31a93441b20 404 Gene3D G3DSA:3.90.1150.10 269 384 2.5E-26 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS31440 6587b5387c85cce07163c31a93441b20 404 PIRSF PIRSF001434 5 386 1.7E-114 T 09-03-2017 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 Reactome: R-HSA-1614558|Reactome: R-HSA-1614603|Reactome: R-HSA-2408508 TK78_RS31440 6587b5387c85cce07163c31a93441b20 404 Gene3D G3DSA:3.40.640.10 18 268 1.4E-72 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS31440 6587b5387c85cce07163c31a93441b20 404 SUPERFAMILY SSF53383 58 384 3.27E-81 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS31440 6587b5387c85cce07163c31a93441b20 404 Pfam PF01053 Cys/Met metabolism PLP-dependent enzyme 19 383 1.1E-91 T 09-03-2017 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 Reactome: R-HSA-1614558|Reactome: R-HSA-1614603|Reactome: R-HSA-2408508 TK78_RS31730 1389977c5f6f7ff1395b1881c6f6bf4f 837 Gene3D G3DSA:3.40.50.300 17 193 1.3E-29 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31730 1389977c5f6f7ff1395b1881c6f6bf4f 837 SUPERFAMILY SSF52540 44 250 1.03E-41 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31730 1389977c5f6f7ff1395b1881c6f6bf4f 837 SUPERFAMILY SSF52540 283 375 1.03E-41 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31730 1389977c5f6f7ff1395b1881c6f6bf4f 837 Pfam PF12029 Domain of unknown function (DUF3516) 374 834 8.7E-217 T 09-03-2017 IPR021904 Protein of unknown function DUF3516 TK78_RS31730 1389977c5f6f7ff1395b1881c6f6bf4f 837 SMART SM00487 27 212 3.0E-16 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS31730 1389977c5f6f7ff1395b1881c6f6bf4f 837 Pfam PF00270 DEAD/DEAH box helicase 33 179 8.4E-11 T 09-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 TK78_RS31730 1389977c5f6f7ff1395b1881c6f6bf4f 837 Pfam PF00271 Helicase conserved C-terminal domain 284 363 7.7E-6 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS31730 1389977c5f6f7ff1395b1881c6f6bf4f 837 Gene3D G3DSA:3.40.50.300 220 379 2.6E-18 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31730 1389977c5f6f7ff1395b1881c6f6bf4f 837 SMART SM00490 277 363 6.3E-13 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS19870 373af6269668b3601e9a35e8f4cb3f40 287 ProDom PD040376 SCO3349 RV0495C/MT0515 ML2435 MB0506C CGL0407 35 267 1.0E-124 T 09-03-2017 TK78_RS21290 e9797e781b1e5d483ab53ac83906c071 401 SUPERFAMILY SSF55060 219 399 6.12E-43 T 09-03-2017 IPR013750 GHMP kinase, C-terminal domain TK78_RS21290 e9797e781b1e5d483ab53ac83906c071 401 PIRSF PIRSF000530 6 401 2.0E-117 T 09-03-2017 IPR000705 Galactokinase GO:0004335|GO:0005524|GO:0006012|GO:0046835 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527 TK78_RS21290 e9797e781b1e5d483ab53ac83906c071 401 ProSitePatterns PS00627 GHMP kinases putative ATP-binding domain. 133 144 - T 09-03-2017 IPR006203 GHMP kinase, ATP-binding, conserved site GO:0005524 TK78_RS21290 e9797e781b1e5d483ab53ac83906c071 401 SUPERFAMILY SSF54211 19 214 1.67E-60 T 09-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold TK78_RS21290 e9797e781b1e5d483ab53ac83906c071 401 Pfam PF08544 GHMP kinases C terminal 299 379 6.3E-13 T 09-03-2017 IPR013750 GHMP kinase, C-terminal domain TK78_RS21290 e9797e781b1e5d483ab53ac83906c071 401 Pfam PF10509 Galactokinase galactose-binding signature 23 70 8.1E-19 T 09-03-2017 IPR019539 Galactokinase galactose-binding domain KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527 TK78_RS21290 e9797e781b1e5d483ab53ac83906c071 401 Gene3D G3DSA:3.30.70.890 223 398 9.3E-51 T 09-03-2017 IPR013750 GHMP kinase, C-terminal domain TK78_RS21290 e9797e781b1e5d483ab53ac83906c071 401 PRINTS PR00959 Mevalonate kinase family signature 174 193 3.1E-39 T 09-03-2017 IPR006206 Mevalonate/galactokinase GO:0005524|GO:0005737|GO:0008152|GO:0016301|GO:0016773 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527 TK78_RS21290 e9797e781b1e5d483ab53ac83906c071 401 PRINTS PR00959 Mevalonate kinase family signature 131 153 3.1E-39 T 09-03-2017 IPR006206 Mevalonate/galactokinase GO:0005524|GO:0005737|GO:0008152|GO:0016301|GO:0016773 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527 TK78_RS21290 e9797e781b1e5d483ab53ac83906c071 401 PRINTS PR00959 Mevalonate kinase family signature 346 363 3.1E-39 T 09-03-2017 IPR006206 Mevalonate/galactokinase GO:0005524|GO:0005737|GO:0008152|GO:0016301|GO:0016773 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527 TK78_RS21290 e9797e781b1e5d483ab53ac83906c071 401 PRINTS PR00959 Mevalonate kinase family signature 38 62 3.1E-39 T 09-03-2017 IPR006206 Mevalonate/galactokinase GO:0005524|GO:0005737|GO:0008152|GO:0016301|GO:0016773 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527 TK78_RS21290 e9797e781b1e5d483ab53ac83906c071 401 Pfam PF00288 GHMP kinases N terminal domain 126 192 1.3E-14 T 09-03-2017 IPR006204 GHMP kinase N-terminal domain GO:0005524 TK78_RS21290 e9797e781b1e5d483ab53ac83906c071 401 TIGRFAM TIGR00131 gal_kin: galactokinase 23 380 7.6E-86 T 09-03-2017 IPR000705 Galactokinase GO:0004335|GO:0005524|GO:0006012|GO:0046835 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527 TK78_RS21290 e9797e781b1e5d483ab53ac83906c071 401 Gene3D G3DSA:3.30.230.10 22 222 9.1E-72 T 09-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TK78_RS21290 e9797e781b1e5d483ab53ac83906c071 401 PRINTS PR00473 Galactokinase signature 104 115 2.3E-21 T 09-03-2017 IPR000705 Galactokinase GO:0004335|GO:0005524|GO:0006012|GO:0046835 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527 TK78_RS21290 e9797e781b1e5d483ab53ac83906c071 401 PRINTS PR00473 Galactokinase signature 40 58 2.3E-21 T 09-03-2017 IPR000705 Galactokinase GO:0004335|GO:0005524|GO:0006012|GO:0046835 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527 TK78_RS21290 e9797e781b1e5d483ab53ac83906c071 401 PRINTS PR00473 Galactokinase signature 124 142 2.3E-21 T 09-03-2017 IPR000705 Galactokinase GO:0004335|GO:0005524|GO:0006012|GO:0046835 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527 TK78_RS21290 e9797e781b1e5d483ab53ac83906c071 401 PRINTS PR00473 Galactokinase signature 283 297 2.3E-21 T 09-03-2017 IPR000705 Galactokinase GO:0004335|GO:0005524|GO:0006012|GO:0046835 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527 TK78_RS21290 e9797e781b1e5d483ab53ac83906c071 401 Hamap MF_00246 Galactokinase [galK]. 38 399 40.684 T 09-03-2017 IPR022963 Galactokinase, bacterial GO:0004335|GO:0006012 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527 TK78_RS13990 02a6f6338d0e1edf2ba897728abb637b 384 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 6 123 5.8E-20 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS13990 02a6f6338d0e1edf2ba897728abb637b 384 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 127 220 1.1E-20 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS13990 02a6f6338d0e1edf2ba897728abb637b 384 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 233 378 8.5E-25 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS13990 02a6f6338d0e1edf2ba897728abb637b 384 SUPERFAMILY SSF56645 2 244 7.59E-72 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS13990 02a6f6338d0e1edf2ba897728abb637b 384 Gene3D G3DSA:1.10.540.10 2 124 1.6E-25 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS13990 02a6f6338d0e1edf2ba897728abb637b 384 Gene3D G3DSA:2.40.110.10 126 222 2.2E-35 T 09-03-2017 TK78_RS13990 02a6f6338d0e1edf2ba897728abb637b 384 Gene3D G3DSA:1.20.140.10 223 382 7.6E-22 T 09-03-2017 TK78_RS13990 02a6f6338d0e1edf2ba897728abb637b 384 SUPERFAMILY SSF47203 233 380 1.22E-16 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 SUPERFAMILY SSF55048 706 767 2.88E-12 T 09-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 Gene3D G3DSA:3.40.47.10 33 297 1.3E-89 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 SMART SM00825 Beta-ketoacyl synthase 37 463 2.4E-223 T 09-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 SMART SM00826 941 1106 1.2E-72 T 09-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 413 528 1.5E-9 T 09-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 SUPERFAMILY SSF51735 1224 1390 1.61E-24 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 198 214 - T 09-03-2017 IPR018201 Beta-ketoacyl synthase, active site TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 Pfam PF14765 Polyketide synthase dehydratase 941 1215 3.4E-53 T 09-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1716 1731 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 293 410 2.9E-44 T 09-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 577 874 4.0E-103 T 09-03-2017 IPR020801 Polyketide synthase, acyl transferase domain TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 Gene3D G3DSA:3.30.70.250 706 766 2.8E-7 T 09-03-2017 TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 Pfam PF00698 Acyl transferase domain 577 861 2.3E-48 T 09-03-2017 IPR014043 Acyl transferase TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 SUPERFAMILY SSF47336 1682 1764 3.01E-19 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 SUPERFAMILY SSF51735 1404 1664 1.36E-43 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 SUPERFAMILY SSF53901 31 407 3.22E-105 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 Pfam PF08659 KR domain 1405 1583 6.9E-56 T 09-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1405 1585 3.7E-56 T 09-03-2017 TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 SMART SM00823 Phosphopantetheine attachment site 1689 1761 2.4E-24 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 Gene3D G3DSA:3.40.50.720 1685 1695 9.6E-36 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 Gene3D G3DSA:3.40.50.720 1404 1589 9.6E-36 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 Gene3D G3DSA:3.40.47.10 298 463 2.0E-64 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 Gene3D G3DSA:3.40.366.10 571 701 1.4E-69 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 Gene3D G3DSA:3.40.366.10 767 872 1.4E-69 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 35 285 2.7E-89 T 09-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 SUPERFAMILY SSF52151 768 865 1.07E-66 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 SUPERFAMILY SSF52151 574 707 1.07E-66 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 Gene3D G3DSA:1.10.1200.10 1696 1761 2.9E-20 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 SMART SM01294 1690 1757 0.0014 T 09-03-2017 TK78_RS31030 0ecb59134deec7f56b48444f2c3ba974 1841 Pfam PF00550 Phosphopantetheine attachment site 1691 1757 3.3E-10 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS25095 e424a5c0e47eb1704fa86d702561b934 464 Gene3D G3DSA:1.20.1250.20 282 452 8.5E-12 T 09-03-2017 TK78_RS25095 e424a5c0e47eb1704fa86d702561b934 464 Gene3D G3DSA:1.20.1250.20 7 199 5.8E-30 T 09-03-2017 TK78_RS25095 e424a5c0e47eb1704fa86d702561b934 464 SUPERFAMILY SSF103473 253 456 5.62E-54 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS25095 e424a5c0e47eb1704fa86d702561b934 464 SUPERFAMILY SSF103473 6 202 5.62E-54 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS25095 e424a5c0e47eb1704fa86d702561b934 464 Pfam PF07690 Major Facilitator Superfamily 11 417 2.1E-44 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS19730 072f03f71dfdf29dca0d9f0c98f58a2a 370 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 337 352 2.2E-9 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS19730 072f03f71dfdf29dca0d9f0c98f58a2a 370 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 322 337 2.2E-9 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS19730 072f03f71dfdf29dca0d9f0c98f58a2a 370 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 290 305 2.2E-9 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS19730 072f03f71dfdf29dca0d9f0c98f58a2a 370 SMART SM00418 288 366 9.2E-23 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS19730 072f03f71dfdf29dca0d9f0c98f58a2a 370 SUPERFAMILY SSF46785 277 360 2.47E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS19730 072f03f71dfdf29dca0d9f0c98f58a2a 370 Pfam PF12840 Helix-turn-helix domain 289 346 4.1E-14 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS19730 072f03f71dfdf29dca0d9f0c98f58a2a 370 Gene3D G3DSA:1.10.10.10 282 364 3.7E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS25820 70dcb6f90848735ad261318ea0813014 77 Pfam PF13370 4Fe-4S single cluster domain of Ferredoxin I 9 62 2.9E-9 T 09-03-2017 TK78_RS25820 70dcb6f90848735ad261318ea0813014 77 SUPERFAMILY SSF54862 5 63 2.96E-10 T 09-03-2017 TK78_RS25820 70dcb6f90848735ad261318ea0813014 77 PRINTS PR00352 3Fe-4S ferredoxin signature 49 61 5.6E-5 T 09-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 TK78_RS25820 70dcb6f90848735ad261318ea0813014 77 PRINTS PR00352 3Fe-4S ferredoxin signature 9 20 5.6E-5 T 09-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 TK78_RS25820 70dcb6f90848735ad261318ea0813014 77 PRINTS PR00352 3Fe-4S ferredoxin signature 20 30 5.6E-5 T 09-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 TK78_RS25820 70dcb6f90848735ad261318ea0813014 77 Gene3D G3DSA:3.30.70.20 5 63 1.3E-12 T 09-03-2017 TK78_RS14350 8dcdbdcdc4cca117392a61d691cec88b 465 Gene3D G3DSA:3.50.50.60 4 204 1.0E-13 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS14350 8dcdbdcdc4cca117392a61d691cec88b 465 SUPERFAMILY SSF51905 117 234 1.61E-15 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS14350 8dcdbdcdc4cca117392a61d691cec88b 465 SUPERFAMILY SSF51905 268 317 1.61E-15 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS14350 8dcdbdcdc4cca117392a61d691cec88b 465 SUPERFAMILY SSF51905 6 62 1.61E-15 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS29095 6ebcf087f7d0f27ab53aebb95b8fd5a0 404 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 249 398 1.4E-33 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS29095 6ebcf087f7d0f27ab53aebb95b8fd5a0 404 Gene3D G3DSA:1.10.540.10 1 132 6.5E-33 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS29095 6ebcf087f7d0f27ab53aebb95b8fd5a0 404 SUPERFAMILY SSF47203 247 403 4.19E-41 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS29095 6ebcf087f7d0f27ab53aebb95b8fd5a0 404 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 9 130 1.3E-14 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS29095 6ebcf087f7d0f27ab53aebb95b8fd5a0 404 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 134 237 1.2E-21 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS29095 6ebcf087f7d0f27ab53aebb95b8fd5a0 404 Gene3D G3DSA:2.40.110.10 133 238 4.1E-42 T 09-03-2017 TK78_RS29095 6ebcf087f7d0f27ab53aebb95b8fd5a0 404 Gene3D G3DSA:1.20.140.10 239 402 2.5E-45 T 09-03-2017 TK78_RS29095 6ebcf087f7d0f27ab53aebb95b8fd5a0 404 SUPERFAMILY SSF56645 1 262 1.18E-65 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS00835 830b6a11f002f57aa376dbcf2df7efab 558 Pfam PF00005 ABC transporter 362 489 1.6E-18 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS00835 830b6a11f002f57aa376dbcf2df7efab 558 Pfam PF00005 ABC transporter 28 176 1.5E-21 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS00835 830b6a11f002f57aa376dbcf2df7efab 558 SUPERFAMILY SSF52540 117 233 3.06E-42 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS00835 830b6a11f002f57aa376dbcf2df7efab 558 SUPERFAMILY SSF52540 11 88 3.06E-42 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS00835 830b6a11f002f57aa376dbcf2df7efab 558 SMART SM00382 368 541 1.2E-9 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS00835 830b6a11f002f57aa376dbcf2df7efab 558 SMART SM00382 35 221 1.4E-12 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS00835 830b6a11f002f57aa376dbcf2df7efab 558 Gene3D G3DSA:3.40.50.300 345 532 4.6E-34 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS00835 830b6a11f002f57aa376dbcf2df7efab 558 Gene3D G3DSA:3.40.50.300 14 265 9.0E-46 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS00835 830b6a11f002f57aa376dbcf2df7efab 558 SUPERFAMILY SSF52540 324 533 1.7E-35 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07635 dc7d55f41393e32e2a32d35c5fb36f1c 561 Pfam PF07521 Zn-dependent metallo-hydrolase RNA specificity domain 370 411 8.2E-10 T 09-03-2017 IPR011108 Zn-dependent metallo-hydrolase, RNA specificity domain TK78_RS07635 dc7d55f41393e32e2a32d35c5fb36f1c 561 SMART SM00849 31 225 3.0E-21 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS07635 dc7d55f41393e32e2a32d35c5fb36f1c 561 Gene3D G3DSA:3.60.15.10 17 265 1.0E-75 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS07635 dc7d55f41393e32e2a32d35c5fb36f1c 561 Hamap MF_01491 Ribonuclease J [rnj]. 14 561 40.95 T 09-03-2017 IPR030854 Ribonuclease J, bacteria GO:0004521|GO:0004534|GO:0006396|GO:0008270|GO:0090501 TK78_RS07635 dc7d55f41393e32e2a32d35c5fb36f1c 561 PIRSF PIRSF004803 11 561 3.5E-207 T 09-03-2017 IPR030854 Ribonuclease J, bacteria GO:0004521|GO:0004534|GO:0006396|GO:0008270|GO:0090501 TK78_RS07635 dc7d55f41393e32e2a32d35c5fb36f1c 561 TIGRFAM TIGR00649 MG423: beta-CASP ribonuclease, RNase J family 20 558 8.2E-152 T 09-03-2017 IPR004613 Ribonuclease J GO:0003723|GO:0046872 TK78_RS07635 dc7d55f41393e32e2a32d35c5fb36f1c 561 Pfam PF00753 Metallo-beta-lactamase superfamily 28 174 3.2E-12 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS07635 dc7d55f41393e32e2a32d35c5fb36f1c 561 SUPERFAMILY SSF56281 19 433 7.74E-95 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS28535 61b1a98a6566e18073261539687f5308 217 Hamap MF_00527 Putative 3-methyladenine DNA glycosylase. 12 201 34.159 T 09-03-2017 IPR003180 Methylpurine-DNA glycosylase (MPG) GO:0003677|GO:0003905|GO:0006284 Reactome: R-HSA-110330|Reactome: R-HSA-110331|Reactome: R-HSA-110357 TK78_RS28535 61b1a98a6566e18073261539687f5308 217 Pfam PF02245 Methylpurine-DNA glycosylase (MPG) 13 198 1.9E-60 T 09-03-2017 IPR003180 Methylpurine-DNA glycosylase (MPG) GO:0003677|GO:0003905|GO:0006284 Reactome: R-HSA-110330|Reactome: R-HSA-110331|Reactome: R-HSA-110357 TK78_RS28535 61b1a98a6566e18073261539687f5308 217 Gene3D G3DSA:3.10.300.10 8 209 6.2E-66 T 09-03-2017 IPR003180 Methylpurine-DNA glycosylase (MPG) GO:0003677|GO:0003905|GO:0006284 Reactome: R-HSA-110330|Reactome: R-HSA-110331|Reactome: R-HSA-110357 TK78_RS28535 61b1a98a6566e18073261539687f5308 217 TIGRFAM TIGR00567 3mg: DNA-3-methyladenine glycosylase 11 201 3.4E-49 T 09-03-2017 IPR003180 Methylpurine-DNA glycosylase (MPG) GO:0003677|GO:0003905|GO:0006284 Reactome: R-HSA-110330|Reactome: R-HSA-110331|Reactome: R-HSA-110357 TK78_RS28535 61b1a98a6566e18073261539687f5308 217 SUPERFAMILY SSF50486 8 206 2.51E-58 T 09-03-2017 IPR011034 Formyl transferase, C-terminal-like GO:0003824 TK78_RS02480 0274e8e13b065e13d875550e966a99d4 375 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 314 337 4.6E-38 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS02480 0274e8e13b065e13d875550e966a99d4 375 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 213 227 4.6E-38 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS02480 0274e8e13b065e13d875550e966a99d4 375 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 338 352 4.6E-38 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS02480 0274e8e13b065e13d875550e966a99d4 375 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 274 294 4.6E-38 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS02480 0274e8e13b065e13d875550e966a99d4 375 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 295 312 4.6E-38 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS02480 0274e8e13b065e13d875550e966a99d4 375 Gene3D G3DSA:2.40.10.10 271 360 1.2E-28 T 09-03-2017 TK78_RS02480 0274e8e13b065e13d875550e966a99d4 375 SUPERFAMILY SSF50494 197 366 6.0E-33 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS02480 0274e8e13b065e13d875550e966a99d4 375 PIRSF PIRSF001134 3 375 8.7E-128 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS02480 0274e8e13b065e13d875550e966a99d4 375 Gene3D G3DSA:2.40.10.10 192 270 4.4E-26 T 09-03-2017 TK78_RS02480 0274e8e13b065e13d875550e966a99d4 375 Pfam PF02983 Alpha-lytic protease prodomain 115 171 3.2E-10 T 09-03-2017 IPR004236 Peptidase S1A, alpha-lytic prodomain GO:0005576|GO:0006508|GO:0008236 TK78_RS02480 0274e8e13b065e13d875550e966a99d4 375 Gene3D G3DSA:3.30.300.50 114 183 3.1E-20 T 09-03-2017 TK78_RS02480 0274e8e13b065e13d875550e966a99d4 375 Gene3D G3DSA:3.30.300.50 33 113 1.4E-29 T 09-03-2017 TK78_RS10270 d0ec18a8d063181f6a6b5db23963d71c 360 Gene3D G3DSA:3.40.50.10490 192 358 3.8E-39 T 09-03-2017 TK78_RS10270 d0ec18a8d063181f6a6b5db23963d71c 360 Pfam PF01380 SIS domain 217 342 8.7E-14 T 09-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 TK78_RS10270 d0ec18a8d063181f6a6b5db23963d71c 360 Pfam PF01380 SIS domain 56 178 2.5E-16 T 09-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 TK78_RS10270 d0ec18a8d063181f6a6b5db23963d71c 360 SUPERFAMILY SSF53697 20 358 2.01E-70 T 09-03-2017 TK78_RS10270 d0ec18a8d063181f6a6b5db23963d71c 360 Gene3D G3DSA:3.40.50.10490 17 186 2.3E-30 T 09-03-2017 TK78_RS01660 ab914b5ccba3035972017e82f13e6c80 160 Pfam PF06236 Tyrosinase co-factor MelC1 27 154 5.3E-23 T 09-03-2017 IPR010928 Tyrosinase co-factor MelC1 GO:0005507|GO:0042438 TK78_RS10030 e20cc491a92cf0c9ac8ed05bbb65ad18 197 SUPERFAMILY SSF81923 79 180 1.49E-15 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS10030 e20cc491a92cf0c9ac8ed05bbb65ad18 197 SUPERFAMILY SSF81923 3 45 1.49E-15 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS10030 e20cc491a92cf0c9ac8ed05bbb65ad18 197 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 18 46 7.2E-5 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS10030 e20cc491a92cf0c9ac8ed05bbb65ad18 197 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 135 179 9.9E-8 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS10030 e20cc491a92cf0c9ac8ed05bbb65ad18 197 Gene3D G3DSA:1.10.1780.10 79 179 7.0E-39 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS10030 e20cc491a92cf0c9ac8ed05bbb65ad18 197 Gene3D G3DSA:1.10.1780.10 1 45 7.0E-39 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS33805 82b013874f6f854f7ed3dbc87c5341b7 355 Gene3D G3DSA:3.20.20.80 49 345 9.7E-41 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS33805 82b013874f6f854f7ed3dbc87c5341b7 355 SUPERFAMILY SSF51445 48 345 2.66E-44 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS33805 82b013874f6f854f7ed3dbc87c5341b7 355 Pfam PF00704 Glycosyl hydrolases family 18 51 262 2.9E-21 T 09-03-2017 IPR001223 Glycoside hydrolase family 18, catalytic domain GO:0004553|GO:0005975 TK78_RS33805 82b013874f6f854f7ed3dbc87c5341b7 355 SMART SM00636 49 338 0.001 T 09-03-2017 IPR011583 Chitinase II GO:0004568|GO:0006032 TK78_RS33805 82b013874f6f854f7ed3dbc87c5341b7 355 ProSitePatterns PS01095 Chitinases family 18 active site. 163 171 - T 09-03-2017 IPR001579 Glycoside hydrolase, chitinase active site GO:0004553|GO:0005975 KEGG: 00520+3.2.1.14|MetaCyc: PWY-6902 TK78_RS07660 a05509708c0aa2286519ec5200b70929 180 SUPERFAMILY SSF48452 106 155 4.88E-6 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS07660 a05509708c0aa2286519ec5200b70929 180 Gene3D G3DSA:1.25.40.10 109 146 2.0E-5 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS27610 220572ac5528db0c0bd553973527e2fa 313 Gene3D G3DSA:3.40.50.300 17 262 2.6E-66 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27610 220572ac5528db0c0bd553973527e2fa 313 Pfam PF00005 ABC transporter 37 196 3.4E-32 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS27610 220572ac5528db0c0bd553973527e2fa 313 Pfam PF12399 Branched-chain amino acid ATP-binding cassette transporter 244 266 1.6E-7 T 09-03-2017 IPR032823 Branched-chain amino acid ATP-binding cassette transporter, C-terminal TK78_RS27610 220572ac5528db0c0bd553973527e2fa 313 SMART SM00382 45 235 3.5E-11 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS27610 220572ac5528db0c0bd553973527e2fa 313 SUPERFAMILY SSF52540 19 266 5.21E-63 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24680 9385315340fc010a485fe14718df9044 328 TIGRFAM TIGR01128 holA: DNA polymerase III, delta subunit 12 318 2.1E-33 T 09-03-2017 IPR005790 DNA polymerase III, delta subunit GO:0003677|GO:0006260 TK78_RS24680 9385315340fc010a485fe14718df9044 328 SUPERFAMILY SSF48019 204 322 1.21E-13 T 09-03-2017 IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal GO:0003677|GO:0006260 Reactome: R-HSA-110312|Reactome: R-HSA-110314|Reactome: R-HSA-110320|Reactome: R-HSA-174411|Reactome: R-HSA-5651801|Reactome: R-HSA-5655862|Reactome: R-HSA-5656121|Reactome: R-HSA-5656169|Reactome: R-HSA-5685942|Reactome: R-HSA-5696397|Reactome: R-HSA-5696400|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210|Reactome: R-HSA-69091 TK78_RS24680 9385315340fc010a485fe14718df9044 328 Gene3D G3DSA:1.10.8.60 139 221 1.0E-6 T 09-03-2017 TK78_RS24680 9385315340fc010a485fe14718df9044 328 Gene3D G3DSA:3.40.50.300 8 106 6.9E-10 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24680 9385315340fc010a485fe14718df9044 328 SUPERFAMILY SSF52540 9 185 7.43E-6 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24680 9385315340fc010a485fe14718df9044 328 Pfam PF06144 DNA polymerase III, delta subunit 17 180 1.3E-11 T 09-03-2017 IPR010372 DNA polymerase III delta, N-terminal GO:0003677|GO:0003887|GO:0006260|GO:0009360 TK78_RS16770 962d40c6568e45ebd57d62fcef358668 388 PIRSF PIRSF000429 9 339 5.8E-22 T 09-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 TK78_RS16770 962d40c6568e45ebd57d62fcef358668 388 SUPERFAMILY SSF53901 11 237 1.8E-24 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS16770 962d40c6568e45ebd57d62fcef358668 388 SUPERFAMILY SSF53901 260 358 7.07E-14 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS16770 962d40c6568e45ebd57d62fcef358668 388 Gene3D G3DSA:3.40.47.10 207 234 8.0E-14 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS16770 962d40c6568e45ebd57d62fcef358668 388 Gene3D G3DSA:3.40.47.10 16 119 8.0E-14 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS02925 ddaf30bfd3252588125ec669c28fd5eb 204 SUPERFAMILY SSF56349 18 174 1.5E-30 T 09-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 TK78_RS02925 ddaf30bfd3252588125ec669c28fd5eb 204 Pfam PF00589 Phage integrase family 21 172 1.7E-19 T 09-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 TK78_RS02925 ddaf30bfd3252588125ec669c28fd5eb 204 Gene3D G3DSA:1.10.443.10 18 174 7.0E-31 T 09-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 TK78_RS04925 2517ebc4a43d0298a5371011b35c57a1 215 Gene3D G3DSA:3.90.45.10 34 202 7.2E-53 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS04925 2517ebc4a43d0298a5371011b35c57a1 215 SUPERFAMILY SSF56420 32 197 1.83E-50 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS04925 2517ebc4a43d0298a5371011b35c57a1 215 PRINTS PR01576 Peptide deformylase signature 156 185 1.7E-30 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS04925 2517ebc4a43d0298a5371011b35c57a1 215 PRINTS PR01576 Peptide deformylase signature 63 92 1.7E-30 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS04925 2517ebc4a43d0298a5371011b35c57a1 215 PRINTS PR01576 Peptide deformylase signature 125 136 1.7E-30 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS04925 2517ebc4a43d0298a5371011b35c57a1 215 PRINTS PR01576 Peptide deformylase signature 137 155 1.7E-30 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS04925 2517ebc4a43d0298a5371011b35c57a1 215 PIRSF PIRSF004749 5 210 1.4E-41 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS04925 2517ebc4a43d0298a5371011b35c57a1 215 Pfam PF01327 Polypeptide deformylase 33 188 2.8E-41 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS04925 2517ebc4a43d0298a5371011b35c57a1 215 Hamap MF_00163 Peptide deformylase [def]. 31 198 27.029 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS04925 2517ebc4a43d0298a5371011b35c57a1 215 TIGRFAM TIGR00079 pept_deformyl: peptide deformylase 35 195 1.3E-33 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS03155 c14e10e67bc174a7b9b1a301764d1b3b 313 TIGRFAM TIGR03465 HpnD: squalene synthase HpnD 23 295 4.2E-96 T 09-03-2017 IPR017828 Squalene/phytoene synthase HpnD GO:0016117|GO:0016767 TK78_RS03155 c14e10e67bc174a7b9b1a301764d1b3b 313 SUPERFAMILY SSF48576 15 299 6.04E-75 T 09-03-2017 IPR008949 Isoprenoid synthase domain TK78_RS03155 c14e10e67bc174a7b9b1a301764d1b3b 313 ProSitePatterns PS01044 Squalene and phytoene synthases signature 1. 138 153 - T 09-03-2017 IPR019845 Squalene/phytoene synthase, conserved site GO:0016765 Reactome: R-HSA-191273|Reactome: R-HSA-1989781|Reactome: R-HSA-2426168 TK78_RS03155 c14e10e67bc174a7b9b1a301764d1b3b 313 ProSitePatterns PS01045 Squalene and phytoene synthases signature 2. 173 198 - T 09-03-2017 IPR019845 Squalene/phytoene synthase, conserved site GO:0016765 Reactome: R-HSA-191273|Reactome: R-HSA-1989781|Reactome: R-HSA-2426168 TK78_RS03155 c14e10e67bc174a7b9b1a301764d1b3b 313 Gene3D G3DSA:1.10.600.10 11 303 1.1E-83 T 09-03-2017 IPR008949 Isoprenoid synthase domain TK78_RS03155 c14e10e67bc174a7b9b1a301764d1b3b 313 Pfam PF00494 Squalene/phytoene synthase 25 284 8.5E-74 T 09-03-2017 IPR002060 Squalene/phytoene synthase GO:0009058|GO:0016740 TK78_RS03675 3a789240bd7088dccc2cefbca6689bcd 426 Gene3D G3DSA:3.40.50.410 43 227 7.5E-13 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS03675 3a789240bd7088dccc2cefbca6689bcd 426 Pfam PF13519 von Willebrand factor type A domain 43 159 3.2E-11 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS03675 3a789240bd7088dccc2cefbca6689bcd 426 SUPERFAMILY SSF53300 41 227 1.01E-23 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS03675 3a789240bd7088dccc2cefbca6689bcd 426 SMART SM00327 40 230 7.1E-16 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS10310 cd6b4f0ea0a5de26bc84405d59e50e86 67 Pfam PF04328 Protein of unknown function (DUF466) 6 67 7.5E-25 T 09-03-2017 IPR007423 Protein of unknown function DUF466 TK78_RS32295 c6dc49a6e5c8ccf0181f430b5b435c1b 222 TIGRFAM TIGR01549 HAD-SF-IA-v1: HAD hydrolase, family IA, variant 1 81 176 2.0E-6 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS32295 c6dc49a6e5c8ccf0181f430b5b435c1b 222 Gene3D G3DSA:3.40.50.1000 4 16 1.5E-31 T 09-03-2017 IPR023214 HAD-like domain TK78_RS32295 c6dc49a6e5c8ccf0181f430b5b435c1b 222 Gene3D G3DSA:3.40.50.1000 87 214 1.5E-31 T 09-03-2017 IPR023214 HAD-like domain TK78_RS32295 c6dc49a6e5c8ccf0181f430b5b435c1b 222 Pfam PF13419 Haloacid dehalogenase-like hydrolase 6 183 3.2E-22 T 09-03-2017 IPR023214 HAD-like domain TK78_RS32295 c6dc49a6e5c8ccf0181f430b5b435c1b 222 SUPERFAMILY SSF56784 4 214 1.93E-46 T 09-03-2017 IPR023214 HAD-like domain TK78_RS06670 ad202640270e25faa31a061ac1909b07 338 Pfam PF04371 Porphyromonas-type peptidyl-arginine deiminase 6 332 1.9E-113 T 09-03-2017 IPR007466 Peptidyl-arginine deiminase, Porphyromonas-type GO:0004668|GO:0009446 KEGG: 00330+3.5.3.12|MetaCyc: PWY-43 TK78_RS06670 ad202640270e25faa31a061ac1909b07 338 Gene3D G3DSA:3.75.10.10 3 333 2.3E-128 T 09-03-2017 TK78_RS06670 ad202640270e25faa31a061ac1909b07 338 SUPERFAMILY SSF55909 3 333 5.18E-122 T 09-03-2017 TK78_RS06435 2ef974814927ad56f81d566bd70eefdb 862 SUPERFAMILY SSF56091 479 618 2.84E-14 T 09-03-2017 TK78_RS06435 2ef974814927ad56f81d566bd70eefdb 862 SUPERFAMILY SSF56091 687 770 2.84E-14 T 09-03-2017 TK78_RS06435 2ef974814927ad56f81d566bd70eefdb 862 Pfam PF16542 PNKP adenylyltransferase domain, ligase domain 479 799 1.6E-143 T 09-03-2017 IPR032380 Polynucleotide kinase-phosphatase, ligase domain TK78_RS06435 2ef974814927ad56f81d566bd70eefdb 862 SUPERFAMILY SSF52540 30 158 1.58E-15 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06435 2ef974814927ad56f81d566bd70eefdb 862 Gene3D G3DSA:3.60.21.10 197 436 3.4E-52 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS06435 2ef974814927ad56f81d566bd70eefdb 862 TIGRFAM TIGR04075 bacter_Pnkp: polynucleotide kinase-phosphatase 22 862 0.0 T 09-03-2017 IPR024028 Polynucleotide kinase-phosphatase, bacterial TK78_RS06435 2ef974814927ad56f81d566bd70eefdb 862 Pfam PF00149 Calcineurin-like phosphoesterase 202 391 5.0E-14 T 09-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 TK78_RS06435 2ef974814927ad56f81d566bd70eefdb 862 Pfam PF16536 PNKP adenylyltransferase domain, C-terminal region 803 862 5.6E-32 T 09-03-2017 IPR032390 Polynucleotide kinase-phosphatase, C-terminal TK78_RS06435 2ef974814927ad56f81d566bd70eefdb 862 SUPERFAMILY SSF56300 194 414 2.42E-45 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS06435 2ef974814927ad56f81d566bd70eefdb 862 Pfam PF13671 AAA domain 30 158 3.8E-23 T 09-03-2017 TK78_RS06435 2ef974814927ad56f81d566bd70eefdb 862 Gene3D G3DSA:3.40.50.300 30 156 3.3E-25 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS32035 6629f09fe745864060eb31c8f60f31cf 298 SUPERFAMILY SSF52833 126 209 1.68E-9 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS32035 6629f09fe745864060eb31c8f60f31cf 298 Pfam PF06999 Sucrase/ferredoxin-like 125 210 3.4E-15 T 09-03-2017 IPR009737 Thioredoxin-like ferredoxin TK78_RS32035 6629f09fe745864060eb31c8f60f31cf 298 Gene3D G3DSA:3.40.30.10 126 211 2.2E-11 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS20140 6e1237902d17b2a57ea2f718aaa8ccf6 203 Pfam PF01872 RibD C-terminal domain 2 185 7.7E-26 T 09-03-2017 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 TK78_RS20140 6e1237902d17b2a57ea2f718aaa8ccf6 203 Gene3D G3DSA:3.40.430.10 2 190 7.6E-30 T 09-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 TK78_RS20140 6e1237902d17b2a57ea2f718aaa8ccf6 203 SUPERFAMILY SSF53597 3 185 3.53E-29 T 09-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 TK78_RS29945 918b564fc5b033f13ab2b040cafc319e 339 Pfam PF01636 Phosphotransferase enzyme family 57 273 3.0E-10 T 09-03-2017 IPR002575 Aminoglycoside phosphotransferase TK78_RS29945 918b564fc5b033f13ab2b040cafc319e 339 Gene3D G3DSA:3.90.1200.10 114 270 3.6E-18 T 09-03-2017 TK78_RS29945 918b564fc5b033f13ab2b040cafc319e 339 SUPERFAMILY SSF56112 47 277 5.1E-18 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS25390 804b06d240b00dbf57e6db96f399dc63 497 Pfam PF07730 Histidine kinase 291 328 1.4E-8 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS25390 804b06d240b00dbf57e6db96f399dc63 497 SUPERFAMILY SSF55781 2 125 6.32E-20 T 09-03-2017 IPR029016 GAF domain-like TK78_RS25390 804b06d240b00dbf57e6db96f399dc63 497 SMART SM00065 14 118 0.0017 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS25390 804b06d240b00dbf57e6db96f399dc63 497 SMART SM00065 139 283 4.5E-8 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS25390 804b06d240b00dbf57e6db96f399dc63 497 SUPERFAMILY SSF55781 141 286 3.93E-19 T 09-03-2017 IPR029016 GAF domain-like TK78_RS25390 804b06d240b00dbf57e6db96f399dc63 497 Pfam PF13185 GAF domain 139 273 1.6E-11 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS25390 804b06d240b00dbf57e6db96f399dc63 497 Pfam PF13185 GAF domain 55 108 5.5E-7 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS25390 804b06d240b00dbf57e6db96f399dc63 497 Gene3D G3DSA:3.30.450.40 62 115 8.1E-13 T 09-03-2017 IPR029016 GAF domain-like TK78_RS25390 804b06d240b00dbf57e6db96f399dc63 497 Gene3D G3DSA:3.30.450.40 129 273 4.3E-19 T 09-03-2017 IPR029016 GAF domain-like TK78_RS25390 804b06d240b00dbf57e6db96f399dc63 497 Gene3D G3DSA:3.30.450.40 3 61 2.3E-4 T 09-03-2017 IPR029016 GAF domain-like TK78_RS21070 2d1e89fa9226938ba67c527d1fa00fd6 155 Pfam PF00583 Acetyltransferase (GNAT) family 65 140 4.4E-13 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS21070 2d1e89fa9226938ba67c527d1fa00fd6 155 SUPERFAMILY SSF55729 20 147 9.04E-21 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS21070 2d1e89fa9226938ba67c527d1fa00fd6 155 Gene3D G3DSA:3.40.630.30 16 153 1.5E-20 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS09360 ff0e755ec0553683b18d91416acd3d47 299 PIRSF PIRSF000103 7 299 8.7E-39 T 09-03-2017 IPR015815 3-hydroxyisobutyrate dehydrogenase-related GO:0016491|GO:0055114 Reactome: R-HSA-70895 TK78_RS09360 ff0e755ec0553683b18d91416acd3d47 299 Pfam PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase 15 166 2.2E-20 T 09-03-2017 IPR006115 6-phosphogluconate dehydrogenase, NADP-binding GO:0004616|GO:0055114 TK78_RS09360 ff0e755ec0553683b18d91416acd3d47 299 SUPERFAMILY SSF48179 172 296 8.05E-6 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS09360 ff0e755ec0553683b18d91416acd3d47 299 Gene3D G3DSA:1.10.1040.10 189 296 2.5E-6 T 09-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 TK78_RS09360 ff0e755ec0553683b18d91416acd3d47 299 SUPERFAMILY SSF51735 15 169 1.32E-28 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS09360 ff0e755ec0553683b18d91416acd3d47 299 Gene3D G3DSA:3.40.50.720 4 170 1.1E-30 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31915 ddf47a9f7f0e12385ab142b99e312fec 514 Pfam PF05108 Type VII secretion system ESX-1, transport TM domain B 3 489 8.3E-99 T 09-03-2017 IPR007795 Type VII secretion system EccB TK78_RS31915 ddf47a9f7f0e12385ab142b99e312fec 514 TIGRFAM TIGR03919 T7SS_EccB: type VII secretion protein EccB 3 483 3.3E-97 T 09-03-2017 IPR007795 Type VII secretion system EccB TK78_RS05675 6bd16b77e6fd76729cad0d7c6c05d11e 464 Gene3D G3DSA:3.20.20.80 6 451 1.9E-141 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS05675 6bd16b77e6fd76729cad0d7c6c05d11e 464 PRINTS PR00131 Glycosyl hydrolase family 1 signature 417 429 1.2E-21 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS05675 6bd16b77e6fd76729cad0d7c6c05d11e 464 PRINTS PR00131 Glycosyl hydrolase family 1 signature 393 410 1.2E-21 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS05675 6bd16b77e6fd76729cad0d7c6c05d11e 464 PRINTS PR00131 Glycosyl hydrolase family 1 signature 372 383 1.2E-21 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS05675 6bd16b77e6fd76729cad0d7c6c05d11e 464 PRINTS PR00131 Glycosyl hydrolase family 1 signature 357 365 1.2E-21 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS05675 6bd16b77e6fd76729cad0d7c6c05d11e 464 PRINTS PR00131 Glycosyl hydrolase family 1 signature 281 295 1.2E-21 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS05675 6bd16b77e6fd76729cad0d7c6c05d11e 464 SUPERFAMILY SSF51445 6 447 7.64E-147 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS05675 6bd16b77e6fd76729cad0d7c6c05d11e 464 ProSitePatterns PS00653 Glycosyl hydrolases family 1 N-terminal signature. 10 24 - T 09-03-2017 IPR033132 Glycosyl hydrolases family 1, N-terminal conserved site TK78_RS05675 6bd16b77e6fd76729cad0d7c6c05d11e 464 Pfam PF00232 Glycosyl hydrolase family 1 6 447 1.7E-128 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS05675 6bd16b77e6fd76729cad0d7c6c05d11e 464 TIGRFAM TIGR03356 BGL: beta-galactosidase 6 439 2.1E-151 T 09-03-2017 IPR017736 Glycoside hydrolase, family 1, beta-glucosidase GO:0008422|GO:0030245 KEGG: 00460+3.2.1.21|KEGG: 00500+3.2.1.21|KEGG: 00940+3.2.1.21|MetaCyc: PWY-3121|MetaCyc: PWY-5176|MetaCyc: PWY-6002|MetaCyc: PWY-6788|MetaCyc: PWY-7089|MetaCyc: PWY-7091|MetaCyc: PWY-7092 TK78_RS04540 e6bee828d26967a86ef4ca2541a602ba 503 Gene3D G3DSA:3.40.640.10 104 361 1.1E-73 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS04540 e6bee828d26967a86ef4ca2541a602ba 503 SUPERFAMILY SSF53383 56 481 8.11E-88 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS04540 e6bee828d26967a86ef4ca2541a602ba 503 Pfam PF00282 Pyridoxal-dependent decarboxylase conserved domain 67 408 5.1E-42 T 09-03-2017 IPR002129 Pyridoxal phosphate-dependent decarboxylase GO:0016831|GO:0019752|GO:0030170 TK78_RS04540 e6bee828d26967a86ef4ca2541a602ba 503 Gene3D G3DSA:3.90.1150.10 362 481 1.2E-24 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS23515 c844742a4bd51c4befc358ad3781f82a 322 Pfam PF01545 Cation efflux family 20 228 1.0E-34 T 09-03-2017 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 TK78_RS23515 c844742a4bd51c4befc358ad3781f82a 322 SUPERFAMILY SSF161111 16 230 3.66E-37 T 09-03-2017 TK78_RS23515 c844742a4bd51c4befc358ad3781f82a 322 Gene3D G3DSA:3.30.70.1350 232 307 2.0E-6 T 09-03-2017 IPR027470 Cation efflux protein, cytoplasmic domain TK78_RS23515 c844742a4bd51c4befc358ad3781f82a 322 TIGRFAM TIGR01297 CDF: cation diffusion facilitator family transporter 19 311 3.6E-46 T 09-03-2017 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 TK78_RS23515 c844742a4bd51c4befc358ad3781f82a 322 Gene3D G3DSA:1.20.1510.10 18 228 7.5E-33 T 09-03-2017 IPR027469 Cation efflux protein transmembrane domain TK78_RS23515 c844742a4bd51c4befc358ad3781f82a 322 SUPERFAMILY SSF160240 233 311 7.59E-9 T 09-03-2017 TK78_RS15520 3921f43fbf3d51e71ad3902f69bc8f25 62 Pfam PF05122 Mobile element transfer protein 12 60 3.4E-29 T 09-03-2017 IPR007806 Mobile element transfer TK78_RS27380 82c4de2c3ee762695deaa46a4adb5c67 296 PRINTS PR00990 Ribokinase signature 104 117 1.8E-36 T 09-03-2017 IPR002139 Ribokinase/fructokinase GO:0004747|GO:0006014 TK78_RS27380 82c4de2c3ee762695deaa46a4adb5c67 296 PRINTS PR00990 Ribokinase signature 6 27 1.8E-36 T 09-03-2017 IPR002139 Ribokinase/fructokinase GO:0004747|GO:0006014 TK78_RS27380 82c4de2c3ee762695deaa46a4adb5c67 296 PRINTS PR00990 Ribokinase signature 209 220 1.8E-36 T 09-03-2017 IPR002139 Ribokinase/fructokinase GO:0004747|GO:0006014 TK78_RS27380 82c4de2c3ee762695deaa46a4adb5c67 296 PRINTS PR00990 Ribokinase signature 33 52 1.8E-36 T 09-03-2017 IPR002139 Ribokinase/fructokinase GO:0004747|GO:0006014 TK78_RS27380 82c4de2c3ee762695deaa46a4adb5c67 296 PRINTS PR00990 Ribokinase signature 171 186 1.8E-36 T 09-03-2017 IPR002139 Ribokinase/fructokinase GO:0004747|GO:0006014 TK78_RS27380 82c4de2c3ee762695deaa46a4adb5c67 296 TIGRFAM TIGR02152 D_ribokin_bact: ribokinase 4 292 1.1E-96 T 09-03-2017 IPR011877 Ribokinase GO:0004747|GO:0006014 KEGG: 00030+2.7.1.15 TK78_RS27380 82c4de2c3ee762695deaa46a4adb5c67 296 SUPERFAMILY SSF53613 1 293 1.87E-79 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS27380 82c4de2c3ee762695deaa46a4adb5c67 296 Hamap MF_01987 Ribokinase [rbsK]. 2 294 26.929 T 09-03-2017 IPR011877 Ribokinase GO:0004747|GO:0006014 KEGG: 00030+2.7.1.15 TK78_RS27380 82c4de2c3ee762695deaa46a4adb5c67 296 Pfam PF00294 pfkB family carbohydrate kinase 1 287 3.8E-71 T 09-03-2017 IPR011611 Carbohydrate kinase PfkB TK78_RS27380 82c4de2c3ee762695deaa46a4adb5c67 296 Gene3D G3DSA:3.40.1190.20 2 294 3.2E-98 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS09960 27e95f922fd0164d3776a0c627fd55ae 1061 SMART SM00304 377 431 2.9E-5 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS09960 27e95f922fd0164d3776a0c627fd55ae 1061 Pfam PF00672 HAMP domain 358 427 8.9E-8 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS09960 27e95f922fd0164d3776a0c627fd55ae 1061 Gene3D G3DSA:3.30.565.10 565 697 8.7E-17 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09960 27e95f922fd0164d3776a0c627fd55ae 1061 Pfam PF08376 Nitrate and nitrite sensing 83 336 8.1E-39 T 09-03-2017 IPR013587 Nitrate/nitrite sensing protein TK78_RS09960 27e95f922fd0164d3776a0c627fd55ae 1061 PRINTS PR00344 Bacterial sensor protein C-terminal signature 682 695 1.3E-5 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS09960 27e95f922fd0164d3776a0c627fd55ae 1061 PRINTS PR00344 Bacterial sensor protein C-terminal signature 621 635 1.3E-5 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS09960 27e95f922fd0164d3776a0c627fd55ae 1061 PRINTS PR00344 Bacterial sensor protein C-terminal signature 658 676 1.3E-5 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS09960 27e95f922fd0164d3776a0c627fd55ae 1061 SUPERFAMILY SSF55874 563 696 1.28E-17 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09960 27e95f922fd0164d3776a0c627fd55ae 1061 SMART SM00387 583 698 2.0E-9 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09960 27e95f922fd0164d3776a0c627fd55ae 1061 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 586 696 3.5E-10 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS19955 c8f390dd9742a3559898f661800804e2 389 SUPERFAMILY SSF52768 6 357 2.88E-99 T 09-03-2017 TK78_RS19955 c8f390dd9742a3559898f661800804e2 389 PRINTS PR01271 Histone deacetylase signature 57 75 6.9E-9 T 09-03-2017 IPR003084 Histone deacetylase GO:0004407|GO:0016575 Reactome: R-HSA-2122947|Reactome: R-HSA-2644606|Reactome: R-HSA-2894862|Reactome: R-HSA-3214815 TK78_RS19955 c8f390dd9742a3559898f661800804e2 389 PRINTS PR01271 Histone deacetylase signature 225 243 6.9E-9 T 09-03-2017 IPR003084 Histone deacetylase GO:0004407|GO:0016575 Reactome: R-HSA-2122947|Reactome: R-HSA-2644606|Reactome: R-HSA-2894862|Reactome: R-HSA-3214815 TK78_RS19955 c8f390dd9742a3559898f661800804e2 389 PRINTS PR01271 Histone deacetylase signature 24 41 6.9E-9 T 09-03-2017 IPR003084 Histone deacetylase GO:0004407|GO:0016575 Reactome: R-HSA-2122947|Reactome: R-HSA-2644606|Reactome: R-HSA-2894862|Reactome: R-HSA-3214815 TK78_RS19955 c8f390dd9742a3559898f661800804e2 389 PRINTS PR01271 Histone deacetylase signature 106 126 6.9E-9 T 09-03-2017 IPR003084 Histone deacetylase GO:0004407|GO:0016575 Reactome: R-HSA-2122947|Reactome: R-HSA-2644606|Reactome: R-HSA-2894862|Reactome: R-HSA-3214815 TK78_RS19955 c8f390dd9742a3559898f661800804e2 389 PRINTS PR01271 Histone deacetylase signature 208 221 6.9E-9 T 09-03-2017 IPR003084 Histone deacetylase GO:0004407|GO:0016575 Reactome: R-HSA-2122947|Reactome: R-HSA-2644606|Reactome: R-HSA-2894862|Reactome: R-HSA-3214815 TK78_RS19955 c8f390dd9742a3559898f661800804e2 389 Pfam PF00850 Histone deacetylase domain 22 316 2.4E-68 T 09-03-2017 IPR023801 Histone deacetylase domain Reactome: R-HSA-2122947|Reactome: R-HSA-2644606|Reactome: R-HSA-2894862 TK78_RS19955 c8f390dd9742a3559898f661800804e2 389 Gene3D G3DSA:3.40.800.20 4 350 2.7E-86 T 09-03-2017 IPR023801 Histone deacetylase domain Reactome: R-HSA-2122947|Reactome: R-HSA-2644606|Reactome: R-HSA-2894862 TK78_RS19955 c8f390dd9742a3559898f661800804e2 389 PRINTS PR01270 Histone deacetylase superfamily signature 161 176 2.5E-17 T 09-03-2017 IPR000286 Histone deacetylase superfamily Reactome: R-HSA-2122947|Reactome: R-HSA-2644606|Reactome: R-HSA-2894862 TK78_RS19955 c8f390dd9742a3559898f661800804e2 389 PRINTS PR01270 Histone deacetylase superfamily signature 247 257 2.5E-17 T 09-03-2017 IPR000286 Histone deacetylase superfamily Reactome: R-HSA-2122947|Reactome: R-HSA-2644606|Reactome: R-HSA-2894862 TK78_RS19955 c8f390dd9742a3559898f661800804e2 389 PRINTS PR01270 Histone deacetylase superfamily signature 128 151 2.5E-17 T 09-03-2017 IPR000286 Histone deacetylase superfamily Reactome: R-HSA-2122947|Reactome: R-HSA-2644606|Reactome: R-HSA-2894862 TK78_RS03840 1d96020d0ef600c65e157992106d707c 523 SUPERFAMILY SSF52540 276 494 8.14E-46 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03840 1d96020d0ef600c65e157992106d707c 523 ProSitePatterns PS00211 ABC transporters family signature. 405 419 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS03840 1d96020d0ef600c65e157992106d707c 523 SMART SM00382 287 481 0.0054 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS03840 1d96020d0ef600c65e157992106d707c 523 SMART SM00382 40 228 1.1E-11 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS03840 1d96020d0ef600c65e157992106d707c 523 SUPERFAMILY SSF52540 15 234 1.96E-57 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03840 1d96020d0ef600c65e157992106d707c 523 Gene3D G3DSA:3.40.50.300 258 496 1.8E-49 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03840 1d96020d0ef600c65e157992106d707c 523 Gene3D G3DSA:3.40.50.300 13 235 2.6E-61 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03840 1d96020d0ef600c65e157992106d707c 523 Pfam PF00005 ABC transporter 279 432 1.3E-18 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS03840 1d96020d0ef600c65e157992106d707c 523 Pfam PF00005 ABC transporter 31 180 1.8E-28 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS31100 fa391976352f1141c3e1a5ce35537838 383 Pfam PF00107 Zinc-binding dehydrogenase 195 321 1.4E-7 T 09-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 TK78_RS31100 fa391976352f1141c3e1a5ce35537838 383 Gene3D G3DSA:3.40.50.720 180 324 9.7E-15 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31100 fa391976352f1141c3e1a5ce35537838 383 SUPERFAMILY SSF51735 180 341 3.42E-13 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS32060 3986bcde0495dc9235e82b2118c59683 451 Gene3D G3DSA:3.40.605.10 1 234 1.6E-71 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS32060 3986bcde0495dc9235e82b2118c59683 451 Pfam PF00171 Aldehyde dehydrogenase family 1 434 9.6E-137 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS32060 3986bcde0495dc9235e82b2118c59683 451 Gene3D G3DSA:3.40.309.10 235 408 6.1E-63 T 09-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 TK78_RS32060 3986bcde0495dc9235e82b2118c59683 451 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 219 226 - T 09-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 TK78_RS32060 3986bcde0495dc9235e82b2118c59683 451 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 247 258 - T 09-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 TK78_RS32060 3986bcde0495dc9235e82b2118c59683 451 SUPERFAMILY SSF53720 1 437 2.62E-136 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS14460 561e8b6b03d32399510b7690257dfe97 156 Gene3D G3DSA:2.30.110.10 15 152 1.3E-41 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS14460 561e8b6b03d32399510b7690257dfe97 156 SUPERFAMILY SSF50475 20 139 1.8E-19 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS14460 561e8b6b03d32399510b7690257dfe97 156 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 21 100 1.8E-7 T 09-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS16895 25a2761bdf40c00090bc0e7b72cf4ca2 464 SUPERFAMILY SSF56349 176 446 4.12E-22 T 09-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 TK78_RS16895 25a2761bdf40c00090bc0e7b72cf4ca2 464 Gene3D G3DSA:1.10.443.10 251 447 6.2E-19 T 09-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 TK78_RS15955 9c05c699fc98cd0b4ac2d04fdad40f83 273 Pfam PF13460 NAD(P)H-binding 7 102 5.0E-19 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS15955 9c05c699fc98cd0b4ac2d04fdad40f83 273 Gene3D G3DSA:3.40.50.720 1 204 1.2E-31 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS15955 9c05c699fc98cd0b4ac2d04fdad40f83 273 SUPERFAMILY SSF51735 2 266 3.96E-48 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS30340 384507b0c0e5c1fec794267ab28aa87f 197 Hamap MF_00328 Guanylate kinase [gmk]. 15 197 33.93 T 09-03-2017 IPR017665 Guanylate kinase GO:0004385|GO:0006163 KEGG: 00230+2.7.4.8|MetaCyc: PWY-7221|Reactome: R-HSA-2161541|Reactome: R-HSA-499943 TK78_RS30340 384507b0c0e5c1fec794267ab28aa87f 197 SUPERFAMILY SSF52540 14 195 1.73E-61 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS30340 384507b0c0e5c1fec794267ab28aa87f 197 Pfam PF00625 Guanylate kinase 17 194 1.5E-42 T 09-03-2017 IPR008145 Guanylate kinase/L-type calcium channel beta subunit TK78_RS30340 384507b0c0e5c1fec794267ab28aa87f 197 SMART SM00072 16 197 6.5E-60 T 09-03-2017 IPR008145 Guanylate kinase/L-type calcium channel beta subunit TK78_RS30340 384507b0c0e5c1fec794267ab28aa87f 197 Gene3D G3DSA:3.40.50.300 16 39 3.4E-38 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS30340 384507b0c0e5c1fec794267ab28aa87f 197 Gene3D G3DSA:3.40.50.300 99 194 3.4E-38 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS30340 384507b0c0e5c1fec794267ab28aa87f 197 Gene3D G3DSA:3.30.63.10 47 98 9.1E-28 T 09-03-2017 TK78_RS30340 384507b0c0e5c1fec794267ab28aa87f 197 TIGRFAM TIGR03263 guanyl_kin: guanylate kinase 18 194 1.7E-68 T 09-03-2017 IPR017665 Guanylate kinase GO:0004385|GO:0006163 KEGG: 00230+2.7.4.8|MetaCyc: PWY-7221|Reactome: R-HSA-2161541|Reactome: R-HSA-499943 TK78_RS30340 384507b0c0e5c1fec794267ab28aa87f 197 ProSitePatterns PS00856 Guanylate kinase-like signature. 51 68 - T 09-03-2017 IPR020590 Guanylate kinase, conserved site KEGG: 00230+2.7.4.8|MetaCyc: PWY-7221 TK78_RS23395 cbcc4eaed20fac67a461535856ad0507 194 Gene3D G3DSA:3.40.630.30 3 187 3.9E-60 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS23395 cbcc4eaed20fac67a461535856ad0507 194 SMART SM01006 23 70 2.1E-14 T 09-03-2017 IPR019432 Siderophore biosynthesis protein, conserved domain TK78_RS23395 cbcc4eaed20fac67a461535856ad0507 194 SUPERFAMILY SSF55729 10 183 3.44E-45 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS23395 cbcc4eaed20fac67a461535856ad0507 194 Pfam PF13523 Acetyltransferase (GNAT) domain 26 169 2.1E-51 T 09-03-2017 TK78_RS30165 0d8f4dfd735664fc38783afd267efb85 262 Gene3D G3DSA:2.40.100.10 88 259 2.3E-33 T 09-03-2017 IPR029000 Cyclophilin-like domain TK78_RS30165 0d8f4dfd735664fc38783afd267efb85 262 SUPERFAMILY SSF50891 91 259 4.82E-32 T 09-03-2017 IPR029000 Cyclophilin-like domain TK78_RS30165 0d8f4dfd735664fc38783afd267efb85 262 Pfam PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD 98 258 7.8E-27 T 09-03-2017 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 TK78_RS00560 6d167fb5b59ead266f0cdfdc26f580e2 191 SUPERFAMILY SSF48498 78 181 1.11E-15 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS00560 6d167fb5b59ead266f0cdfdc26f580e2 191 SUPERFAMILY SSF46689 8 70 2.0E-9 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS00560 6d167fb5b59ead266f0cdfdc26f580e2 191 Gene3D G3DSA:1.10.10.60 1 49 7.1E-14 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS00560 6d167fb5b59ead266f0cdfdc26f580e2 191 Gene3D G3DSA:1.10.357.10 51 184 2.2E-33 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS31415 72ef369d8da8f0dc0badfd9d2b60ce2c 148 SUPERFAMILY SSF46785 7 65 8.49E-18 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS31415 72ef369d8da8f0dc0badfd9d2b60ce2c 148 SMART SM00344 7 112 2.6E-34 T 09-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 TK78_RS31415 72ef369d8da8f0dc0badfd9d2b60ce2c 148 Gene3D G3DSA:1.10.10.10 7 58 5.2E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS31415 72ef369d8da8f0dc0badfd9d2b60ce2c 148 Pfam PF01037 Lrp/AsnC ligand binding domain 79 138 1.2E-14 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS31415 72ef369d8da8f0dc0badfd9d2b60ce2c 148 ProSitePatterns PS00519 AsnC-type HTH domain signature. 24 50 - T 09-03-2017 IPR019885 Transcription regulator HTH, AsnC-type, conserved site TK78_RS31415 72ef369d8da8f0dc0badfd9d2b60ce2c 148 SUPERFAMILY SSF54909 67 141 9.92E-17 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS31415 72ef369d8da8f0dc0badfd9d2b60ce2c 148 Gene3D G3DSA:3.30.70.920 59 133 3.2E-17 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS31415 72ef369d8da8f0dc0badfd9d2b60ce2c 148 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 6 22 1.6E-13 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS31415 72ef369d8da8f0dc0badfd9d2b60ce2c 148 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 22 33 1.6E-13 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS31415 72ef369d8da8f0dc0badfd9d2b60ce2c 148 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 33 52 1.6E-13 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS31415 72ef369d8da8f0dc0badfd9d2b60ce2c 148 Pfam PF13404 AsnC-type helix-turn-helix domain 7 47 5.7E-17 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS14385 16f5c6fbef2dc41c2d7629b603fbab76 176 ProSitePatterns PS01117 MarR-type HTH domain signature. 94 128 - T 09-03-2017 IPR023187 Transcriptional regulator MarR-type, conserved site TK78_RS14385 16f5c6fbef2dc41c2d7629b603fbab76 176 Gene3D G3DSA:1.10.10.10 19 170 5.5E-39 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS14385 16f5c6fbef2dc41c2d7629b603fbab76 176 PRINTS PR00598 Bacterial regulatory protein MarR family signature 115 131 1.8E-6 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS14385 16f5c6fbef2dc41c2d7629b603fbab76 176 PRINTS PR00598 Bacterial regulatory protein MarR family signature 145 165 1.8E-6 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS14385 16f5c6fbef2dc41c2d7629b603fbab76 176 PRINTS PR00598 Bacterial regulatory protein MarR family signature 96 111 1.8E-6 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS14385 16f5c6fbef2dc41c2d7629b603fbab76 176 SMART SM00347 52 155 2.4E-19 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS14385 16f5c6fbef2dc41c2d7629b603fbab76 176 SUPERFAMILY SSF46785 21 168 1.09E-33 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS14385 16f5c6fbef2dc41c2d7629b603fbab76 176 Pfam PF12802 MarR family 57 119 5.8E-13 T 09-03-2017 TK78_RS09165 27fb0b80fc329985e1a8088093b5ca47 141 TIGRFAM TIGR02241 TIGR02241: conserved hypothetical phage tail region protein 7 139 9.4E-25 T 09-03-2017 IPR011747 Conserved hypothetical protein CHP02241 TK78_RS09165 27fb0b80fc329985e1a8088093b5ca47 141 Pfam PF06841 T4-like virus tail tube protein gp19 9 139 1.5E-32 T 09-03-2017 IPR010667 Bacteriophage T4, Gp19, tail tube GO:0005198 TK78_RS15585 cb076fe008513df28a293a1a600acd5a 127 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 72 87 5.0E-23 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS15585 cb076fe008513df28a293a1a600acd5a 127 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 37 52 5.0E-23 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS15585 cb076fe008513df28a293a1a600acd5a 127 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 59 70 5.0E-23 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS15585 cb076fe008513df28a293a1a600acd5a 127 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 87 102 5.0E-23 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS15585 cb076fe008513df28a293a1a600acd5a 127 Gene3D G3DSA:1.10.10.10 16 114 2.4E-33 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS15585 cb076fe008513df28a293a1a600acd5a 127 ProSitePatterns PS00846 Bacterial regulatory proteins, arsR family signature. 61 79 - T 09-03-2017 IPR018334 ArsR-type transcription regulator, HTH motif GO:0003700|GO:0005622|GO:0006355 TK78_RS15585 cb076fe008513df28a293a1a600acd5a 127 SUPERFAMILY SSF46785 18 115 3.61E-28 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS15585 cb076fe008513df28a293a1a600acd5a 127 SMART SM00418 35 115 2.5E-27 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS15585 cb076fe008513df28a293a1a600acd5a 127 Pfam PF01022 Bacterial regulatory protein, arsR family 42 89 4.0E-16 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS22625 23ad55f0bdbc3cce233ce01e63c2daad 316 TIGRFAM TIGR01136 cysKM: cysteine synthase 9 298 2.8E-110 T 09-03-2017 IPR005856 Cysteine synthase GO:0004124|GO:0006535 KEGG: 00270+2.5.1.47|KEGG: 00920+2.5.1.47|MetaCyc: PWY-6936 TK78_RS22625 23ad55f0bdbc3cce233ce01e63c2daad 316 Gene3D G3DSA:3.40.50.1100 149 302 7.4E-67 T 09-03-2017 TK78_RS22625 23ad55f0bdbc3cce233ce01e63c2daad 316 Gene3D G3DSA:3.40.50.1100 1 41 7.4E-67 T 09-03-2017 TK78_RS22625 23ad55f0bdbc3cce233ce01e63c2daad 316 ProSitePatterns PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 32 50 - T 09-03-2017 IPR001216 Cysteine synthase/cystathionine beta-synthase, pyridoxal-phosphate attachment site GO:0006535 TK78_RS22625 23ad55f0bdbc3cce233ce01e63c2daad 316 SUPERFAMILY SSF53686 5 295 7.2E-87 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS22625 23ad55f0bdbc3cce233ce01e63c2daad 316 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 9 286 5.6E-68 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS22625 23ad55f0bdbc3cce233ce01e63c2daad 316 Gene3D G3DSA:3.40.50.1100 42 143 3.4E-38 T 09-03-2017 TK78_RS18895 ea581e73339b281d2b301ccf3c16c11a 149 Pfam PF02580 D-Tyr-tRNA(Tyr) deacylase 2 148 8.6E-48 T 09-03-2017 IPR003732 D-aminoacyl-tRNA deacylase DTD GO:0005737|GO:0016788|GO:0019478 TK78_RS18895 ea581e73339b281d2b301ccf3c16c11a 149 Hamap MF_00518 D-aminoacyl-tRNA deacylase [dtd]. 1 149 29.861 T 09-03-2017 IPR003732 D-aminoacyl-tRNA deacylase DTD GO:0005737|GO:0016788|GO:0019478 TK78_RS18895 ea581e73339b281d2b301ccf3c16c11a 149 SUPERFAMILY SSF69500 1 148 2.49E-43 T 09-03-2017 IPR023509 D-Tyr tRNAtyr deacylase-like domain TK78_RS18895 ea581e73339b281d2b301ccf3c16c11a 149 TIGRFAM TIGR00256 TIGR00256: D-tyrosyl-tRNA(Tyr) deacylase 1 149 2.7E-37 T 09-03-2017 IPR003732 D-aminoacyl-tRNA deacylase DTD GO:0005737|GO:0016788|GO:0019478 TK78_RS18895 ea581e73339b281d2b301ccf3c16c11a 149 Gene3D G3DSA:3.50.80.10 1 148 7.5E-51 T 09-03-2017 IPR023509 D-Tyr tRNAtyr deacylase-like domain TK78_RS27180 bf618ef38386137bd85b306a47f7644f 192 Gene3D G3DSA:3.40.50.1820 6 191 5.4E-23 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS27180 bf618ef38386137bd85b306a47f7644f 192 Pfam PF01738 Dienelactone hydrolase family 6 191 4.0E-21 T 09-03-2017 IPR002925 Dienelactone hydrolase GO:0016787 TK78_RS27180 bf618ef38386137bd85b306a47f7644f 192 SUPERFAMILY SSF53474 6 190 1.95E-24 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS27865 a877b2db9ca499ffc8b30d95832e8251 329 Pfam PF14527 WhiA LAGLIDADG-like domain 127 218 1.5E-23 T 09-03-2017 TK78_RS27865 a877b2db9ca499ffc8b30d95832e8251 329 TIGRFAM TIGR00647 DNA_bind_WhiA: DNA-binding protein WhiA 6 304 6.0E-111 T 09-03-2017 TK78_RS27865 a877b2db9ca499ffc8b30d95832e8251 329 Pfam PF10298 WhiA N-terminal LAGLIDADG-like domain 20 104 7.1E-26 T 09-03-2017 IPR018478 Sporulation transcription regulator WhiA, N-terminal domain TK78_RS27865 a877b2db9ca499ffc8b30d95832e8251 329 Pfam PF02650 WhiA C-terminal HTH domain 221 303 9.3E-19 T 09-03-2017 IPR023054 Sporulation regulator WhiA, C-terminal TK78_RS27865 a877b2db9ca499ffc8b30d95832e8251 329 Hamap MF_01420 Putative sporulation transcription regulator WhiA [whiA]. 3 306 29.372 T 09-03-2017 IPR003802 Sporulation regulator WhiA GO:0043937 TK78_RS21920 d8b9b841acb29177e8c60bf648236b8c 571 Pfam PF13399 LytR cell envelope-related transcriptional attenuator 440 532 2.2E-12 T 09-03-2017 IPR027381 Putative LytR/CpsA/Psr regulator, C-terminal domain TK78_RS21920 d8b9b841acb29177e8c60bf648236b8c 571 TIGRFAM TIGR00350 lytR_cpsA_psr: cell envelope-related function transcriptional attenuator common domain 169 329 1.1E-36 T 09-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain TK78_RS21920 d8b9b841acb29177e8c60bf648236b8c 571 Pfam PF03816 Cell envelope-related transcriptional attenuator domain 169 329 3.4E-38 T 09-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain TK78_RS13690 bc8559365ca256c333bf14a10b4c005a 54 Gene3D G3DSA:3.40.630.30 1 51 4.4E-5 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS00145 6063fce22b4e64cdf500de018b5d7046 142 Pfam PF13474 SnoaL-like domain 9 129 1.1E-15 T 09-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain TK78_RS00145 6063fce22b4e64cdf500de018b5d7046 142 Gene3D G3DSA:3.10.450.50 4 126 2.6E-24 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS00145 6063fce22b4e64cdf500de018b5d7046 142 SUPERFAMILY SSF54427 6 126 3.63E-26 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS04330 6bb7e655e115537f2d411f832e0cd4f0 463 SUPERFAMILY SSF53474 125 241 1.74E-13 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04330 6bb7e655e115537f2d411f832e0cd4f0 463 SUPERFAMILY SSF53474 346 414 1.74E-13 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04330 6bb7e655e115537f2d411f832e0cd4f0 463 Gene3D G3DSA:3.40.50.1820 339 431 1.5E-15 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04330 6bb7e655e115537f2d411f832e0cd4f0 463 Gene3D G3DSA:3.40.50.1820 125 241 1.5E-15 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04330 6bb7e655e115537f2d411f832e0cd4f0 463 Pfam PF10605 3HB-oligomer hydrolase (3HBOH) 339 448 4.9E-9 T 09-03-2017 IPR016582 D-(-)-3-hydroxybutyrate oligomer hydrolase, putative GO:0005615|GO:0019605|GO:0047989 KEGG: 00650+3.1.1.22 TK78_RS04330 6bb7e655e115537f2d411f832e0cd4f0 463 Pfam PF07519 Tannase and feruloyl esterase 112 231 9.5E-9 T 09-03-2017 IPR011118 Tannase/feruloyl esterase MetaCyc: PWY-6784 TK78_RS15175 4e858052009b0005165d787ad21bb4eb 193 Pfam PF13523 Acetyltransferase (GNAT) domain 27 169 3.2E-49 T 09-03-2017 TK78_RS15175 4e858052009b0005165d787ad21bb4eb 193 SMART SM01006 23 70 1.4E-12 T 09-03-2017 IPR019432 Siderophore biosynthesis protein, conserved domain TK78_RS15175 4e858052009b0005165d787ad21bb4eb 193 SUPERFAMILY SSF55729 18 183 1.4E-42 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS15175 4e858052009b0005165d787ad21bb4eb 193 Gene3D G3DSA:3.40.630.30 14 188 4.4E-56 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS03130 2e91b8ef866b9762314004d109eff892 339 SUPERFAMILY SSF102114 24 308 3.53E-47 T 09-03-2017 TK78_RS03130 2e91b8ef866b9762314004d109eff892 339 Pfam PF11946 Domain of unknown function (DUF3463) 196 328 9.1E-56 T 09-03-2017 IPR022563 Domain of unknown function DUF3463 TK78_RS03130 2e91b8ef866b9762314004d109eff892 339 Pfam PF13394 4Fe-4S single cluster domain 37 114 2.7E-5 T 09-03-2017 TK78_RS03130 2e91b8ef866b9762314004d109eff892 339 TIGRFAM TIGR03470 HpnH: hopanoid biosynthesis associated radical SAM protein HpnH 1 318 2.0E-163 T 09-03-2017 IPR017833 Hopanoid biosynthesis associated radical SAM protein HpnH TK78_RS03130 2e91b8ef866b9762314004d109eff892 339 Gene3D G3DSA:3.20.20.70 21 310 1.7E-39 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS03130 2e91b8ef866b9762314004d109eff892 339 Pfam PF04055 Radical SAM superfamily 34 186 7.6E-16 T 09-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 TK78_RS31890 7b21fe607c26a421000e94a74e1d76e2 411 SMART SM00458 284 411 7.0E-27 T 09-03-2017 IPR000772 Ricin B, lectin domain TK78_RS31890 7b21fe607c26a421000e94a74e1d76e2 411 Gene3D G3DSA:2.80.10.50 286 410 1.1E-34 T 09-03-2017 TK78_RS31890 7b21fe607c26a421000e94a74e1d76e2 411 SUPERFAMILY SSF50370 280 410 2.85E-36 T 09-03-2017 IPR000772 Ricin B, lectin domain TK78_RS31890 7b21fe607c26a421000e94a74e1d76e2 411 Pfam PF00652 Ricin-type beta-trefoil lectin domain 287 409 1.7E-26 T 09-03-2017 IPR000772 Ricin B, lectin domain TK78_RS04635 2f6e5d19ae9ee7959211206027e9de3e 384 Pfam PF03033 Glycosyltransferase family 28 N-terminal domain 7 141 1.1E-31 T 09-03-2017 IPR004276 Glycosyltransferase family 28, N-terminal domain GO:0005975|GO:0016758|GO:0030259 KEGG: 00052+2.4.1.22|KEGG: 00550+2.4.1.227|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TK78_RS04635 2f6e5d19ae9ee7959211206027e9de3e 384 Gene3D G3DSA:3.40.50.2000 269 346 1.3E-6 T 09-03-2017 TK78_RS04635 2f6e5d19ae9ee7959211206027e9de3e 384 SUPERFAMILY SSF53756 7 374 1.23E-88 T 09-03-2017 TK78_RS04635 2f6e5d19ae9ee7959211206027e9de3e 384 TIGRFAM TIGR01133 murG: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase 2 367 1.1E-75 T 09-03-2017 IPR006009 N-acetylglucosaminyltransferase, MurG GO:0009252|GO:0050511 KEGG: 00052+2.4.1.22|KEGG: 00550+2.4.1.227|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TK78_RS04635 2f6e5d19ae9ee7959211206027e9de3e 384 Pfam PF04101 Glycosyltransferase family 28 C-terminal domain 198 362 7.8E-34 T 09-03-2017 IPR007235 Glycosyl transferase, family 28, C-terminal GO:0016758 KEGG: 00052+2.4.1.22|KEGG: 00550+2.4.1.227|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471|Reactome: R-HSA-446193|Reactome: R-HSA-5633231 TK78_RS04635 2f6e5d19ae9ee7959211206027e9de3e 384 Gene3D G3DSA:3.40.50.2000 3 209 8.6E-51 T 09-03-2017 TK78_RS04635 2f6e5d19ae9ee7959211206027e9de3e 384 Hamap MF_00033 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [murG]. 7 373 30.392 T 09-03-2017 IPR006009 N-acetylglucosaminyltransferase, MurG GO:0009252|GO:0050511 KEGG: 00052+2.4.1.22|KEGG: 00550+2.4.1.227|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TK78_RS14835 c14747600d4a1d6e485929b8e8c54f7c 600 SUPERFAMILY SSF81606 378 579 1.83E-9 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS14835 c14747600d4a1d6e485929b8e8c54f7c 600 SMART SM00331 366 578 1.6E-39 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS14835 c14747600d4a1d6e485929b8e8c54f7c 600 SUPERFAMILY SSF55781 192 342 3.19E-8 T 09-03-2017 IPR029016 GAF domain-like TK78_RS14835 c14747600d4a1d6e485929b8e8c54f7c 600 Gene3D G3DSA:3.30.450.40 180 339 2.3E-15 T 09-03-2017 IPR029016 GAF domain-like TK78_RS14835 c14747600d4a1d6e485929b8e8c54f7c 600 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 389 578 6.7E-41 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS11430 4e5dfc5bac048f35ce366a5f73792916 290 SUPERFAMILY SSF51735 21 289 5.96E-74 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS11430 4e5dfc5bac048f35ce366a5f73792916 290 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 164 172 5.0E-13 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS11430 4e5dfc5bac048f35ce366a5f73792916 290 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 109 120 5.0E-13 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS11430 4e5dfc5bac048f35ce366a5f73792916 290 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 184 203 5.0E-13 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS11430 4e5dfc5bac048f35ce366a5f73792916 290 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 184 203 3.3E-42 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS11430 4e5dfc5bac048f35ce366a5f73792916 290 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 23 40 3.3E-42 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS11430 4e5dfc5bac048f35ce366a5f73792916 290 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 205 222 3.3E-42 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS11430 4e5dfc5bac048f35ce366a5f73792916 290 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 251 271 3.3E-42 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS11430 4e5dfc5bac048f35ce366a5f73792916 290 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 109 120 3.3E-42 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS11430 4e5dfc5bac048f35ce366a5f73792916 290 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 158 174 3.3E-42 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS11430 4e5dfc5bac048f35ce366a5f73792916 290 Gene3D G3DSA:3.40.50.720 17 289 1.0E-76 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS11430 4e5dfc5bac048f35ce366a5f73792916 290 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 171 199 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS11430 4e5dfc5bac048f35ce366a5f73792916 290 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 28 288 1.3E-57 T 09-03-2017 TK78_RS01565 5ecd95d39a33679e7fbb2413810111ac 431 PRINTS PR00793 Prolyl aminopeptidase (S33) family signature 50 58 2.3E-8 T 09-03-2017 IPR002410 Peptidase S33 GO:0006508|GO:0008233 KEGG: 00330+3.4.11.5 TK78_RS01565 5ecd95d39a33679e7fbb2413810111ac 431 PRINTS PR00793 Prolyl aminopeptidase (S33) family signature 80 91 2.3E-8 T 09-03-2017 IPR002410 Peptidase S33 GO:0006508|GO:0008233 KEGG: 00330+3.4.11.5 TK78_RS01565 5ecd95d39a33679e7fbb2413810111ac 431 PRINTS PR00793 Prolyl aminopeptidase (S33) family signature 139 153 2.3E-8 T 09-03-2017 IPR002410 Peptidase S33 GO:0006508|GO:0008233 KEGG: 00330+3.4.11.5 TK78_RS01565 5ecd95d39a33679e7fbb2413810111ac 431 SUPERFAMILY SSF53474 15 212 6.25E-26 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS01565 5ecd95d39a33679e7fbb2413810111ac 431 Gene3D G3DSA:3.40.50.1820 312 425 6.0E-53 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS01565 5ecd95d39a33679e7fbb2413810111ac 431 Gene3D G3DSA:3.40.50.1820 13 241 6.0E-53 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS01565 5ecd95d39a33679e7fbb2413810111ac 431 Pfam PF00561 alpha/beta hydrolase fold 48 218 2.3E-16 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS26075 e3b5124fa3a51288d48cd6716693e481 284 Gene3D G3DSA:3.10.310.10 9 126 1.3E-38 T 09-03-2017 TK78_RS26075 e3b5124fa3a51288d48cd6716693e481 284 TIGRFAM TIGR00654 PhzF_family: phenazine biosynthesis protein, PhzF family 6 280 1.0E-52 T 09-03-2017 IPR003719 Phenazine biosynthesis PhzF protein GO:0003824|GO:0009058 TK78_RS26075 e3b5124fa3a51288d48cd6716693e481 284 Pfam PF02567 Phenazine biosynthesis-like protein 13 281 3.9E-65 T 09-03-2017 IPR003719 Phenazine biosynthesis PhzF protein GO:0003824|GO:0009058 TK78_RS26075 e3b5124fa3a51288d48cd6716693e481 284 Gene3D G3DSA:3.10.310.10 127 274 1.9E-38 T 09-03-2017 TK78_RS26075 e3b5124fa3a51288d48cd6716693e481 284 PIRSF PIRSF016184 5 284 2.6E-65 T 09-03-2017 IPR003719 Phenazine biosynthesis PhzF protein GO:0003824|GO:0009058 TK78_RS26075 e3b5124fa3a51288d48cd6716693e481 284 SUPERFAMILY SSF54506 8 281 4.36E-59 T 09-03-2017 TK78_RS12100 3e00b2bff319a08b2021452ccc533068 190 Pfam PF04892 VanZ like family 24 144 3.3E-15 T 09-03-2017 IPR006976 VanZ-like TK78_RS12690 6c349bd02cba92377b40ebafe9850ca6 568 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 36 46 1.2E-30 T 09-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 TK78_RS12690 6c349bd02cba92377b40ebafe9850ca6 568 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 341 347 1.2E-30 T 09-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 TK78_RS12690 6c349bd02cba92377b40ebafe9850ca6 568 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 23 35 1.2E-30 T 09-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 TK78_RS12690 6c349bd02cba92377b40ebafe9850ca6 568 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 98 110 1.2E-30 T 09-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 TK78_RS12690 6c349bd02cba92377b40ebafe9850ca6 568 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 52 64 1.2E-30 T 09-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 TK78_RS12690 6c349bd02cba92377b40ebafe9850ca6 568 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 371 383 1.2E-30 T 09-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 TK78_RS12690 6c349bd02cba92377b40ebafe9850ca6 568 SUPERFAMILY SSF51905 290 351 2.27E-37 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS12690 6c349bd02cba92377b40ebafe9850ca6 568 SUPERFAMILY SSF51905 24 253 2.27E-37 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS12690 6c349bd02cba92377b40ebafe9850ca6 568 Gene3D G3DSA:3.50.50.60 19 233 2.4E-42 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS12690 6c349bd02cba92377b40ebafe9850ca6 568 ProSitePatterns PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. 376 386 - T 09-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 TK78_RS12690 6c349bd02cba92377b40ebafe9850ca6 568 Gene3D G3DSA:3.30.9.10 234 346 4.5E-4 T 09-03-2017 TK78_RS12690 6c349bd02cba92377b40ebafe9850ca6 568 Pfam PF01266 FAD dependent oxidoreductase 24 377 4.9E-50 T 09-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 TK78_RS12690 6c349bd02cba92377b40ebafe9850ca6 568 Pfam PF16901 C-terminal domain of alpha-glycerophosphate oxidase 404 528 1.1E-29 T 09-03-2017 IPR031656 Alpha-glycerophosphate oxidase, C-terminal KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 TK78_RS23115 c8c0a3b8857c307e28d1b927490af3be 413 Gene3D G3DSA:3.40.390.10 213 256 4.8E-4 T 09-03-2017 IPR024079 Metallopeptidase, catalytic domain GO:0008237 TK78_RS23115 c8c0a3b8857c307e28d1b927490af3be 413 TIGRFAM TIGR03296 M6dom_TIGR03296: M6 family metalloprotease domain 79 341 2.6E-55 T 09-03-2017 IPR008757 Peptidase M6-like, domain GO:0006508|GO:0008233 TK78_RS31480 45728488cb8818cd1bb0a444159a20cb 294 Gene3D G3DSA:3.10.450.50 173 288 2.5E-12 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS31480 45728488cb8818cd1bb0a444159a20cb 294 Pfam PF04542 Sigma-70 region 2 10 74 2.1E-17 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS31480 45728488cb8818cd1bb0a444159a20cb 294 Pfam PF08281 Sigma-70, region 4 112 162 2.0E-13 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS31480 45728488cb8818cd1bb0a444159a20cb 294 SUPERFAMILY SSF54427 173 288 3.62E-12 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS31480 45728488cb8818cd1bb0a444159a20cb 294 Gene3D G3DSA:1.10.1740.10 7 82 1.4E-14 T 09-03-2017 TK78_RS31480 45728488cb8818cd1bb0a444159a20cb 294 SUPERFAMILY SSF88659 97 167 5.79E-12 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS31480 45728488cb8818cd1bb0a444159a20cb 294 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 7 165 3.7E-18 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS31480 45728488cb8818cd1bb0a444159a20cb 294 Gene3D G3DSA:1.10.10.10 107 165 5.2E-13 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS31480 45728488cb8818cd1bb0a444159a20cb 294 SUPERFAMILY SSF88946 7 85 7.85E-16 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS31480 45728488cb8818cd1bb0a444159a20cb 294 TIGRFAM TIGR02957 SigX4: RNA polymerase sigma-70 factor, TIGR02957 family 9 290 1.6E-99 T 09-03-2017 IPR014303 RNA polymerase sigma-70, ECF type TK78_RS13070 3fbd9b70a6ec27e73e6aa29a5bdfca9e 60 TIGRFAM TIGR01308 rpmD_bact: ribosomal protein uL30 4 58 1.8E-27 T 09-03-2017 IPR005996 Ribosomal protein L30, bacterial-type GO:0003735|GO:0006412|GO:0015934 TK78_RS13070 3fbd9b70a6ec27e73e6aa29a5bdfca9e 60 Hamap MF_01371_B 50S ribosomal protein L30 [rpmD]. 1 58 19.933 T 09-03-2017 IPR005996 Ribosomal protein L30, bacterial-type GO:0003735|GO:0006412|GO:0015934 TK78_RS13070 3fbd9b70a6ec27e73e6aa29a5bdfca9e 60 Pfam PF00327 Ribosomal protein L30p/L7e 4 54 2.2E-17 T 09-03-2017 IPR016082 Ribosomal protein L30, ferredoxin-like fold domain TK78_RS13070 3fbd9b70a6ec27e73e6aa29a5bdfca9e 60 SUPERFAMILY SSF55129 1 60 1.11E-21 T 09-03-2017 IPR016082 Ribosomal protein L30, ferredoxin-like fold domain TK78_RS13070 3fbd9b70a6ec27e73e6aa29a5bdfca9e 60 Gene3D G3DSA:3.30.1390.20 1 59 1.4E-28 T 09-03-2017 IPR016082 Ribosomal protein L30, ferredoxin-like fold domain TK78_RS13070 3fbd9b70a6ec27e73e6aa29a5bdfca9e 60 PIRSF PIRSF002211 1 60 5.0E-29 T 09-03-2017 IPR005996 Ribosomal protein L30, bacterial-type GO:0003735|GO:0006412|GO:0015934 TK78_RS23160 bb1115b83438b3ead069ec5f2a501613 461 SUPERFAMILY SSF48452 183 302 5.39E-6 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS23160 bb1115b83438b3ead069ec5f2a501613 461 SUPERFAMILY SSF48452 351 386 5.39E-6 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS23160 bb1115b83438b3ead069ec5f2a501613 461 Gene3D G3DSA:1.25.40.10 360 420 3.5E-7 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS23160 bb1115b83438b3ead069ec5f2a501613 461 Gene3D G3DSA:1.25.40.10 190 307 3.5E-7 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS14615 7ff453a9b8353f98f63e6d2d57e195bd 484 Pfam PF00860 Permease family 41 440 2.9E-31 T 09-03-2017 IPR006043 Xanthine/uracil/vitamin C permease GO:0005215|GO:0006810|GO:0016020|GO:0055085 TK78_RS28870 234d8ffcbb863fb6767ef735dd9b3a44 403 TIGRFAM TIGR04276 FxsC_Cterm: FxsC C-terminal domain 189 381 8.0E-80 T 09-03-2017 IPR026367 FxsC C-terminal domain TK78_RS28870 234d8ffcbb863fb6767ef735dd9b3a44 403 Gene3D G3DSA:3.40.50.10140 29 113 7.8E-6 T 09-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 TK78_RS28870 234d8ffcbb863fb6767ef735dd9b3a44 403 Pfam PF13676 TIR domain 27 108 7.6E-9 T 09-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 TK78_RS28870 234d8ffcbb863fb6767ef735dd9b3a44 403 SUPERFAMILY SSF52200 28 113 8.89E-9 T 09-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 TK78_RS19830 d01a9408ddfb640e19f4070e7ce61496 237 Pfam PF00486 Transcriptional regulatory protein, C terminal 164 235 5.2E-23 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS19830 d01a9408ddfb640e19f4070e7ce61496 237 SUPERFAMILY SSF52172 3 122 1.02E-39 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS19830 d01a9408ddfb640e19f4070e7ce61496 237 SMART SM00448 4 114 3.4E-39 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS19830 d01a9408ddfb640e19f4070e7ce61496 237 SUPERFAMILY SSF46894 143 235 2.3E-27 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS19830 d01a9408ddfb640e19f4070e7ce61496 237 Gene3D G3DSA:3.40.50.2300 3 126 2.3E-40 T 09-03-2017 TK78_RS19830 d01a9408ddfb640e19f4070e7ce61496 237 SMART SM00862 164 235 1.0E-24 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS19830 d01a9408ddfb640e19f4070e7ce61496 237 Gene3D G3DSA:1.10.10.10 145 236 1.2E-30 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS19830 d01a9408ddfb640e19f4070e7ce61496 237 Pfam PF00072 Response regulator receiver domain 6 115 1.9E-26 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS21610 d1ac2d390ca3e3da9669b3ff326c8a3d 256 ProSitePatterns PS00211 ABC transporters family signature. 153 167 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS21610 d1ac2d390ca3e3da9669b3ff326c8a3d 256 SUPERFAMILY SSF52540 17 233 2.9E-69 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS21610 d1ac2d390ca3e3da9669b3ff326c8a3d 256 SMART SM00382 43 229 4.7E-14 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS21610 d1ac2d390ca3e3da9669b3ff326c8a3d 256 Pfam PF00005 ABC transporter 34 180 4.5E-31 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS21610 d1ac2d390ca3e3da9669b3ff326c8a3d 256 Gene3D G3DSA:3.40.50.300 18 233 1.1E-65 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23545 e23bd3c1691c8a82950cffb7c860fca7 796 SUPERFAMILY SSF52540 22 70 5.12E-33 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23545 e23bd3c1691c8a82950cffb7c860fca7 796 SUPERFAMILY SSF52540 327 458 5.12E-33 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23545 e23bd3c1691c8a82950cffb7c860fca7 796 Pfam PF00005 ABC transporter 506 714 3.1E-10 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS23545 e23bd3c1691c8a82950cffb7c860fca7 796 Gene3D G3DSA:1.20.1580.10 554 677 1.8E-34 T 09-03-2017 TK78_RS23545 e23bd3c1691c8a82950cffb7c860fca7 796 SUPERFAMILY SSF52540 498 767 1.92E-36 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23545 e23bd3c1691c8a82950cffb7c860fca7 796 Gene3D G3DSA:1.10.8.280 188 299 2.0E-8 T 09-03-2017 TK78_RS23545 e23bd3c1691c8a82950cffb7c860fca7 796 Gene3D G3DSA:3.40.50.300 678 792 2.0E-54 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23545 e23bd3c1691c8a82950cffb7c860fca7 796 Gene3D G3DSA:3.40.50.300 366 481 7.6E-52 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23545 e23bd3c1691c8a82950cffb7c860fca7 796 Gene3D G3DSA:3.40.50.300 8 107 7.6E-52 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23545 e23bd3c1691c8a82950cffb7c860fca7 796 Gene3D G3DSA:3.40.50.300 489 550 2.0E-54 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23545 e23bd3c1691c8a82950cffb7c860fca7 796 Gene3D G3DSA:1.20.1580.10 110 185 1.9E-30 T 09-03-2017 TK78_RS23545 e23bd3c1691c8a82950cffb7c860fca7 796 Gene3D G3DSA:1.20.1580.10 300 365 1.9E-30 T 09-03-2017 TK78_RS22590 8bdb3a1a49f1c9d87d4aa647359bd2cc 208 Pfam PF09438 Domain of unknown function (DUF2017) 9 207 1.9E-59 T 09-03-2017 IPR018561 Domain of unknown function DUF2017 TK78_RS20030 34b7c1eef4c7935c7f850c12d372a37d 159 SUPERFAMILY SSF48371 40 145 1.04E-5 T 09-03-2017 IPR016024 Armadillo-type fold GO:0005488 TK78_RS20030 34b7c1eef4c7935c7f850c12d372a37d 159 Gene3D G3DSA:1.25.10.10 44 141 2.1E-5 T 09-03-2017 IPR011989 Armadillo-like helical TK78_RS14200 c3665d4d68493e942fc5062f2748206c 244 SUPERFAMILY SSF52096 5 242 6.92E-62 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS14200 c3665d4d68493e942fc5062f2748206c 244 Gene3D G3DSA:1.10.12.10 188 242 2.0E-14 T 09-03-2017 IPR014748 Crontonase, C-terminal TK78_RS14200 c3665d4d68493e942fc5062f2748206c 244 Gene3D G3DSA:3.90.226.10 6 172 1.1E-44 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS14200 c3665d4d68493e942fc5062f2748206c 244 Pfam PF00378 Enoyl-CoA hydratase/isomerase 9 242 3.7E-47 T 09-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 TK78_RS32405 645d6cdcc94ea12dae855f2d69e47539 223 SUPERFAMILY SSF52172 1 170 5.48E-33 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS32405 645d6cdcc94ea12dae855f2d69e47539 223 SMART SM00862 143 215 6.0E-22 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS32405 645d6cdcc94ea12dae855f2d69e47539 223 Gene3D G3DSA:3.40.50.2300 1 117 3.6E-29 T 09-03-2017 TK78_RS32405 645d6cdcc94ea12dae855f2d69e47539 223 Pfam PF00486 Transcriptional regulatory protein, C terminal 146 215 2.3E-21 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS32405 645d6cdcc94ea12dae855f2d69e47539 223 Gene3D G3DSA:1.10.10.10 121 216 4.8E-30 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32405 645d6cdcc94ea12dae855f2d69e47539 223 SMART SM00448 1 110 8.9E-25 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS32405 645d6cdcc94ea12dae855f2d69e47539 223 Pfam PF00072 Response regulator receiver domain 1 111 5.2E-19 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS02215 cc64eddf3e84422329352028dd0b895c 724 SMART SM00091 167 233 4.1E-9 T 09-03-2017 IPR000014 PAS domain TK78_RS02215 cc64eddf3e84422329352028dd0b895c 724 Gene3D G3DSA:3.30.70.270 294 460 5.0E-55 T 09-03-2017 TK78_RS02215 cc64eddf3e84422329352028dd0b895c 724 SUPERFAMILY SSF55073 298 454 6.28E-45 T 09-03-2017 IPR029787 Nucleotide cyclase TK78_RS02215 cc64eddf3e84422329352028dd0b895c 724 SMART SM00267 282 453 1.4E-63 T 09-03-2017 IPR000160 GGDEF domain TK78_RS02215 cc64eddf3e84422329352028dd0b895c 724 Gene3D G3DSA:3.30.450.20 153 278 9.5E-25 T 09-03-2017 TK78_RS02215 cc64eddf3e84422329352028dd0b895c 724 Pfam PF00990 Diguanylate cyclase, GGDEF domain 293 449 2.8E-44 T 09-03-2017 IPR000160 GGDEF domain TK78_RS02215 cc64eddf3e84422329352028dd0b895c 724 Pfam PF00563 EAL domain 470 709 9.8E-69 T 09-03-2017 IPR001633 EAL domain TK78_RS02215 cc64eddf3e84422329352028dd0b895c 724 SMART SM00052 463 714 1.6E-105 T 09-03-2017 IPR001633 EAL domain TK78_RS02215 cc64eddf3e84422329352028dd0b895c 724 SUPERFAMILY SSF141868 470 719 2.22E-81 T 09-03-2017 IPR001633 EAL domain TK78_RS02215 cc64eddf3e84422329352028dd0b895c 724 Pfam PF08448 PAS fold 179 283 1.1E-10 T 09-03-2017 IPR013656 PAS fold-4 TK78_RS02215 cc64eddf3e84422329352028dd0b895c 724 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 165 285 1.9E-22 T 09-03-2017 IPR000014 PAS domain TK78_RS02215 cc64eddf3e84422329352028dd0b895c 724 Gene3D G3DSA:3.20.20.450 467 719 2.9E-97 T 09-03-2017 IPR001633 EAL domain TK78_RS02215 cc64eddf3e84422329352028dd0b895c 724 SUPERFAMILY SSF55785 153 280 5.76E-23 T 09-03-2017 IPR000014 PAS domain TK78_RS02215 cc64eddf3e84422329352028dd0b895c 724 SMART SM00086 240 282 1.1E-5 T 09-03-2017 IPR001610 PAC motif TK78_RS02215 cc64eddf3e84422329352028dd0b895c 724 TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain 291 453 3.3E-34 T 09-03-2017 IPR000160 GGDEF domain TK78_RS06975 c8a5e4e0635250758a1a9ea0e38f1464 270 Pfam PF00005 ABC transporter 36 182 1.4E-34 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS06975 c8a5e4e0635250758a1a9ea0e38f1464 270 SUPERFAMILY SSF52540 17 235 3.79E-69 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06975 c8a5e4e0635250758a1a9ea0e38f1464 270 Gene3D G3DSA:3.40.50.300 16 235 2.0E-71 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06975 c8a5e4e0635250758a1a9ea0e38f1464 270 ProSitePatterns PS00211 ABC transporters family signature. 155 169 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS06975 c8a5e4e0635250758a1a9ea0e38f1464 270 SMART SM00382 45 231 2.2E-18 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS04845 7acf03eca0f4b40bf3256517f8472630 233 SUPERFAMILY SSF52172 12 143 1.04E-31 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS04845 7acf03eca0f4b40bf3256517f8472630 233 ProSitePatterns PS00622 LuxR-type HTH domain signature. 184 211 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS04845 7acf03eca0f4b40bf3256517f8472630 233 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 200 212 5.0E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS04845 7acf03eca0f4b40bf3256517f8472630 233 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 170 184 5.0E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS04845 7acf03eca0f4b40bf3256517f8472630 233 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 184 200 5.0E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS04845 7acf03eca0f4b40bf3256517f8472630 233 Gene3D G3DSA:3.40.50.2300 8 133 1.6E-34 T 09-03-2017 TK78_RS04845 7acf03eca0f4b40bf3256517f8472630 233 Pfam PF00196 Bacterial regulatory proteins, luxR family 170 223 2.3E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS04845 7acf03eca0f4b40bf3256517f8472630 233 Pfam PF00072 Response regulator receiver domain 16 126 7.7E-28 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS04845 7acf03eca0f4b40bf3256517f8472630 233 Gene3D G3DSA:1.10.10.10 134 231 2.4E-27 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS04845 7acf03eca0f4b40bf3256517f8472630 233 SMART SM00421 167 224 4.8E-19 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS04845 7acf03eca0f4b40bf3256517f8472630 233 SUPERFAMILY SSF46894 159 231 2.01E-18 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS04845 7acf03eca0f4b40bf3256517f8472630 233 SMART SM00448 13 126 2.6E-28 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS20560 df2c597dcf01169c815436a26386cdb3 230 Gene3D G3DSA:3.40.50.150 15 201 2.8E-31 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS20560 df2c597dcf01169c815436a26386cdb3 230 SUPERFAMILY SSF53335 3 204 4.47E-31 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS20560 df2c597dcf01169c815436a26386cdb3 230 Pfam PF13649 Methyltransferase domain 63 151 3.5E-16 T 09-03-2017 TK78_RS07145 1f252a494ff1022de08162d0c7bcb2c7 431 PIRSF PIRSF500136 13 423 9.6E-117 T 09-03-2017 IPR028359 UDP-N-acetyl-D-mannosamine/glucosamine dehydrogenase GO:0000271|GO:0016628|GO:0055114 TK78_RS07145 1f252a494ff1022de08162d0c7bcb2c7 431 SMART SM00984 333 426 2.5E-11 T 09-03-2017 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 TK78_RS07145 1f252a494ff1022de08162d0c7bcb2c7 431 Gene3D G3DSA:3.40.50.720 18 236 1.4E-46 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07145 1f252a494ff1022de08162d0c7bcb2c7 431 Gene3D G3DSA:3.40.50.720 248 379 2.4E-33 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07145 1f252a494ff1022de08162d0c7bcb2c7 431 Pfam PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 19 197 5.2E-36 T 09-03-2017 IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 TK78_RS07145 1f252a494ff1022de08162d0c7bcb2c7 431 SUPERFAMILY SSF48179 215 302 4.76E-27 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS07145 1f252a494ff1022de08162d0c7bcb2c7 431 SUPERFAMILY SSF51735 20 203 1.71E-35 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07145 1f252a494ff1022de08162d0c7bcb2c7 431 PIRSF PIRSF000124 18 419 2.2E-55 T 09-03-2017 IPR017476 UDP-glucose/GDP-mannose dehydrogenase GO:0016616|GO:0055114 Reactome: R-HSA-173599 TK78_RS07145 1f252a494ff1022de08162d0c7bcb2c7 431 SUPERFAMILY SSF52413 322 408 2.22E-17 T 09-03-2017 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 TK78_RS07145 1f252a494ff1022de08162d0c7bcb2c7 431 Pfam PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 333 408 1.3E-12 T 09-03-2017 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 TK78_RS07145 1f252a494ff1022de08162d0c7bcb2c7 431 TIGRFAM TIGR03026 NDP-sugDHase: nucleotide sugar dehydrogenase 19 405 5.0E-109 T 09-03-2017 IPR017476 UDP-glucose/GDP-mannose dehydrogenase GO:0016616|GO:0055114 Reactome: R-HSA-173599 TK78_RS07145 1f252a494ff1022de08162d0c7bcb2c7 431 Pfam PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 216 303 1.4E-25 T 09-03-2017 IPR014026 UDP-glucose/GDP-mannose dehydrogenase, dimerisation GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 TK78_RS00370 f6b20b690b45b10cf48ea8a535560df9 150 PRINTS PR00598 Bacterial regulatory protein MarR family signature 74 89 3.3E-5 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS00370 f6b20b690b45b10cf48ea8a535560df9 150 PRINTS PR00598 Bacterial regulatory protein MarR family signature 93 109 3.3E-5 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS00370 f6b20b690b45b10cf48ea8a535560df9 150 PRINTS PR00598 Bacterial regulatory protein MarR family signature 124 144 3.3E-5 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS00370 f6b20b690b45b10cf48ea8a535560df9 150 SUPERFAMILY SSF46785 11 146 1.8E-24 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS00370 f6b20b690b45b10cf48ea8a535560df9 150 SMART SM00347 31 134 3.8E-16 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS00370 f6b20b690b45b10cf48ea8a535560df9 150 Gene3D G3DSA:1.10.10.10 2 148 2.7E-29 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS00370 f6b20b690b45b10cf48ea8a535560df9 150 Pfam PF01047 MarR family 40 97 8.7E-15 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS31535 a227c9c0f22ab530ea0a3c2c4c7ca003 232 PIRSF PIRSF006755 1 206 1.5E-37 T 09-03-2017 IPR004472 Dethiobiotin synthase BioD GO:0000287|GO:0004141|GO:0005524|GO:0009102 KEGG: 00780+6.3.3.3|MetaCyc: PWY-7380 TK78_RS31535 a227c9c0f22ab530ea0a3c2c4c7ca003 232 Hamap MF_00336 ATP-dependent dethiobiotin synthetase BioD [bioD]. 2 202 24.881 T 09-03-2017 IPR004472 Dethiobiotin synthase BioD GO:0000287|GO:0004141|GO:0005524|GO:0009102 KEGG: 00780+6.3.3.3|MetaCyc: PWY-7380 TK78_RS31535 a227c9c0f22ab530ea0a3c2c4c7ca003 232 Gene3D G3DSA:3.40.50.300 2 203 1.0E-57 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31535 a227c9c0f22ab530ea0a3c2c4c7ca003 232 SUPERFAMILY SSF52540 1 201 2.79E-38 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31535 a227c9c0f22ab530ea0a3c2c4c7ca003 232 Pfam PF13500 AAA domain 5 201 7.7E-35 T 09-03-2017 TK78_RS31535 a227c9c0f22ab530ea0a3c2c4c7ca003 232 TIGRFAM TIGR00347 bioD: dethiobiotin synthase 7 169 8.7E-32 T 09-03-2017 IPR004472 Dethiobiotin synthase BioD GO:0000287|GO:0004141|GO:0005524|GO:0009102 KEGG: 00780+6.3.3.3|MetaCyc: PWY-7380 TK78_RS33155 28e89986f4689b185c295a0c8794fcbd 343 Pfam PF13377 Periplasmic binding protein-like domain 168 333 6.9E-39 T 09-03-2017 TK78_RS33155 28e89986f4689b185c295a0c8794fcbd 343 ProSitePatterns PS00356 LacI-type HTH domain signature. 5 23 - T 09-03-2017 TK78_RS33155 28e89986f4689b185c295a0c8794fcbd 343 Pfam PF00356 Bacterial regulatory proteins, lacI family 4 49 2.3E-17 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS33155 28e89986f4689b185c295a0c8794fcbd 343 Gene3D G3DSA:1.10.260.40 3 54 4.6E-25 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS33155 28e89986f4689b185c295a0c8794fcbd 343 SMART SM00354 2 72 1.0E-23 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS33155 28e89986f4689b185c295a0c8794fcbd 343 Gene3D G3DSA:3.40.50.2300 172 312 1.0E-51 T 09-03-2017 TK78_RS33155 28e89986f4689b185c295a0c8794fcbd 343 SUPERFAMILY SSF47413 3 60 6.19E-18 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS33155 28e89986f4689b185c295a0c8794fcbd 343 Gene3D G3DSA:3.40.50.2300 55 171 9.2E-39 T 09-03-2017 TK78_RS33155 28e89986f4689b185c295a0c8794fcbd 343 SUPERFAMILY SSF53822 63 335 3.0E-67 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS27945 9d2dfe744b91062b98b547a9cdc70a76 317 ProSitePatterns PS00943 UbiA prenyltransferase family signature. 83 105 - T 09-03-2017 IPR030470 UbiA prenyltransferase conserved site TK78_RS27945 9d2dfe744b91062b98b547a9cdc70a76 317 Pfam PF01040 UbiA prenyltransferase family 44 300 4.4E-66 T 09-03-2017 IPR000537 UbiA prenyltransferase family GO:0004659|GO:0016021 TK78_RS27945 9d2dfe744b91062b98b547a9cdc70a76 317 TIGRFAM TIGR01473 cyoE_ctaB: protoheme IX farnesyltransferase 30 313 9.7E-97 T 09-03-2017 IPR006369 Protohaem IX farnesyltransferase GO:0008495|GO:0016021|GO:0048034 Reactome: R-HSA-189451 TK78_RS27945 9d2dfe744b91062b98b547a9cdc70a76 317 Hamap MF_00154 Protoheme IX farnesyltransferase [cyoE]. 28 315 19.506 T 09-03-2017 IPR006369 Protohaem IX farnesyltransferase GO:0008495|GO:0016021|GO:0048034 Reactome: R-HSA-189451 TK78_RS16025 fc418bc3ea6216c0777c7b752fff6c0e 387 Pfam PF00155 Aminotransferase class I and II 33 384 2.4E-64 T 09-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TK78_RS16025 fc418bc3ea6216c0777c7b752fff6c0e 387 SUPERFAMILY SSF53383 6 386 8.91E-109 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS16025 fc418bc3ea6216c0777c7b752fff6c0e 387 Gene3D G3DSA:3.90.1150.10 273 384 4.7E-21 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS16025 fc418bc3ea6216c0777c7b752fff6c0e 387 Gene3D G3DSA:3.40.640.10 45 272 2.4E-78 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS17640 63d499d67017f720fe0e42268b98978b 343 Pfam PF02780 Transketolase, C-terminal domain 209 330 7.6E-37 T 09-03-2017 IPR033248 Transketolase, C-terminal domain TK78_RS17640 63d499d67017f720fe0e42268b98978b 343 Gene3D G3DSA:3.40.50.920 213 334 2.1E-39 T 09-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 TK78_RS17640 63d499d67017f720fe0e42268b98978b 343 Gene3D G3DSA:3.40.50.970 16 211 5.5E-75 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS17640 63d499d67017f720fe0e42268b98978b 343 SUPERFAMILY SSF52922 206 336 3.4E-37 T 09-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 TK78_RS17640 63d499d67017f720fe0e42268b98978b 343 Pfam PF02779 Transketolase, pyrimidine binding domain 18 191 1.3E-45 T 09-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain TK78_RS17640 63d499d67017f720fe0e42268b98978b 343 SUPERFAMILY SSF52518 17 201 1.72E-67 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS17640 63d499d67017f720fe0e42268b98978b 343 SMART SM00861 18 193 5.2E-67 T 09-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain TK78_RS05010 d0ebfc6b4d9896cdbf37743d35392464 380 Gene3D G3DSA:2.130.10.10 40 377 2.3E-88 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS05010 d0ebfc6b4d9896cdbf37743d35392464 380 SUPERFAMILY SSF51004 58 380 1.1E-45 T 09-03-2017 IPR011048 Cytochrome cd1-nitrite reductase-like, haem d1 domain TK78_RS05010 d0ebfc6b4d9896cdbf37743d35392464 380 Pfam PF10282 Lactonase, 7-bladed beta-propeller 40 376 6.1E-97 T 09-03-2017 IPR019405 Lactonase, 7-bladed beta propeller KEGG: 00030+3.1.1.31 TK78_RS09295 6a1533163f2727101c9b3bcf29a5d444 438 Gene3D G3DSA:3.40.50.10330 175 249 5.3E-6 T 09-03-2017 IPR017438 Inorganic polyphosphate/ATP-NAD kinase, domain 1 GO:0003951|GO:0008152 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 TK78_RS09295 6a1533163f2727101c9b3bcf29a5d444 438 SUPERFAMILY SSF111331 127 413 1.16E-50 T 09-03-2017 IPR016064 NAD kinase/diacylglycerol kinase-like domain TK78_RS09295 6a1533163f2727101c9b3bcf29a5d444 438 SMART SM00046 130 255 0.0057 T 09-03-2017 IPR001206 Diacylglycerol kinase, catalytic domain GO:0016301 TK78_RS09295 6a1533163f2727101c9b3bcf29a5d444 438 Pfam PF00781 Diacylglycerol kinase catalytic domain 132 251 6.6E-20 T 09-03-2017 IPR001206 Diacylglycerol kinase, catalytic domain GO:0016301 TK78_RS09625 ab34c4fcaa19609924b0441f9364278e 260 Gene3D G3DSA:3.40.50.300 3 231 2.4E-70 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09625 ab34c4fcaa19609924b0441f9364278e 260 SMART SM00382 32 216 1.9E-14 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS09625 ab34c4fcaa19609924b0441f9364278e 260 SUPERFAMILY SSF52540 4 230 1.02E-62 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09625 ab34c4fcaa19609924b0441f9364278e 260 Pfam PF00005 ABC transporter 26 166 5.9E-30 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS09625 ab34c4fcaa19609924b0441f9364278e 260 ProSitePatterns PS00211 ABC transporters family signature. 139 153 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS03585 b4ed11355396d07380bf17064bafceae 286 Gene3D G3DSA:1.10.260.40 12 70 6.5E-10 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS03585 b4ed11355396d07380bf17064bafceae 286 SMART SM00530 18 73 1.0E-8 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS03585 b4ed11355396d07380bf17064bafceae 286 Pfam PF13560 Helix-turn-helix domain 15 75 8.3E-13 T 09-03-2017 TK78_RS03585 b4ed11355396d07380bf17064bafceae 286 SUPERFAMILY SSF47413 14 69 1.07E-8 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS27140 84bfc7ddd37038123fb57055d2f1abf1 382 TIGRFAM TIGR03544 DivI1A_domain: DivIVA domain 3 38 1.3E-16 T 09-03-2017 IPR019933 DivIVA domain TK78_RS27140 84bfc7ddd37038123fb57055d2f1abf1 382 Pfam PF05103 DivIVA protein 3 67 2.5E-14 T 09-03-2017 IPR007793 DivIVA family TK78_RS14215 0acd66983c3aff7f515a5dd5328c36ee 669 ProSitePatterns PS00188 Biotin-requiring enzymes attachment site. 607 624 - T 09-03-2017 IPR001882 Biotin-binding site Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TK78_RS14215 0acd66983c3aff7f515a5dd5328c36ee 669 Pfam PF00289 Biotin carboxylase, N-terminal domain 3 111 1.4E-42 T 09-03-2017 IPR005481 Biotin carboxylase-like, N-terminal domain Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TK78_RS14215 0acd66983c3aff7f515a5dd5328c36ee 669 Pfam PF02785 Biotin carboxylase C-terminal domain 327 433 1.8E-31 T 09-03-2017 IPR005482 Biotin carboxylase, C-terminal Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TK78_RS14215 0acd66983c3aff7f515a5dd5328c36ee 669 SMART SM00878 327 433 5.7E-47 T 09-03-2017 IPR005482 Biotin carboxylase, C-terminal Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TK78_RS14215 0acd66983c3aff7f515a5dd5328c36ee 669 Gene3D G3DSA:3.30.1490.20 145 194 4.1E-15 T 09-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 TK78_RS14215 0acd66983c3aff7f515a5dd5328c36ee 669 SUPERFAMILY SSF56059 84 326 2.65E-60 T 09-03-2017 TK78_RS14215 0acd66983c3aff7f515a5dd5328c36ee 669 ProSitePatterns PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 278 285 - T 09-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 TK78_RS14215 0acd66983c3aff7f515a5dd5328c36ee 669 Pfam PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 145 314 1.1E-60 T 09-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 TK78_RS14215 0acd66983c3aff7f515a5dd5328c36ee 669 Gene3D G3DSA:3.40.50.20 3 130 4.0E-48 T 09-03-2017 IPR016185 Pre-ATP-grasp domain TK78_RS14215 0acd66983c3aff7f515a5dd5328c36ee 669 SUPERFAMILY SSF52440 3 114 5.68E-46 T 09-03-2017 IPR016185 Pre-ATP-grasp domain TK78_RS14215 0acd66983c3aff7f515a5dd5328c36ee 669 Gene3D G3DSA:2.40.50.100 581 650 1.2E-19 T 09-03-2017 TK78_RS14215 0acd66983c3aff7f515a5dd5328c36ee 669 SUPERFAMILY SSF51246 321 438 1.1E-35 T 09-03-2017 IPR011054 Rudiment single hybrid motif Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TK78_RS14215 0acd66983c3aff7f515a5dd5328c36ee 669 Pfam PF00364 Biotin-requiring enzyme 585 649 3.9E-13 T 09-03-2017 IPR000089 Biotin/lipoyl attachment TK78_RS14215 0acd66983c3aff7f515a5dd5328c36ee 669 SUPERFAMILY SSF51230 573 650 1.57E-17 T 09-03-2017 IPR011053 Single hybrid motif TK78_RS14215 0acd66983c3aff7f515a5dd5328c36ee 669 Gene3D G3DSA:3.30.470.20 196 438 1.3E-92 T 09-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 TK78_RS19220 575f67f6f0a136845e9aa9a59ec462e2 755 SUPERFAMILY SSF56059 445 676 1.77E-35 T 09-03-2017 TK78_RS19220 575f67f6f0a136845e9aa9a59ec462e2 755 Pfam PF13535 ATP-grasp domain 491 637 1.4E-23 T 09-03-2017 TK78_RS19220 575f67f6f0a136845e9aa9a59ec462e2 755 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 9 296 8.1E-44 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS19220 575f67f6f0a136845e9aa9a59ec462e2 755 Gene3D G3DSA:3.40.50.1100 135 308 1.8E-43 T 09-03-2017 TK78_RS19220 575f67f6f0a136845e9aa9a59ec462e2 755 Gene3D G3DSA:3.30.470.20 542 736 6.2E-11 T 09-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 TK78_RS19220 575f67f6f0a136845e9aa9a59ec462e2 755 SUPERFAMILY SSF53686 3 312 1.96E-62 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS19220 575f67f6f0a136845e9aa9a59ec462e2 755 Gene3D G3DSA:3.30.1490.20 468 541 1.4E-13 T 09-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 TK78_RS19220 575f67f6f0a136845e9aa9a59ec462e2 755 Gene3D G3DSA:3.40.50.1100 37 134 6.6E-18 T 09-03-2017 TK78_RS19220 575f67f6f0a136845e9aa9a59ec462e2 755 SMART SM01209 454 634 2.6E-4 T 09-03-2017 TK78_RS19220 575f67f6f0a136845e9aa9a59ec462e2 755 Gene3D G3DSA:3.40.50.20 432 467 7.9E-6 T 09-03-2017 IPR016185 Pre-ATP-grasp domain TK78_RS09330 1cc5c52c13676af2617a6c278397fc73 406 Pfam PF05426 Alginate lyase 117 330 1.5E-14 T 09-03-2017 IPR008397 Alginate lyase domain GO:0016829|GO:0042597 KEGG: 00051+4.2.2.3|MetaCyc: PWY-6986 TK78_RS09330 1cc5c52c13676af2617a6c278397fc73 406 SUPERFAMILY SSF48230 48 258 1.65E-45 T 09-03-2017 IPR008929 Chondroitin AC/alginate lyase Reactome: R-HSA-2022923 TK78_RS09330 1cc5c52c13676af2617a6c278397fc73 406 SUPERFAMILY SSF48230 288 357 1.65E-45 T 09-03-2017 IPR008929 Chondroitin AC/alginate lyase Reactome: R-HSA-2022923 TK78_RS09330 1cc5c52c13676af2617a6c278397fc73 406 Gene3D G3DSA:1.50.10.110 39 376 5.1E-37 T 09-03-2017 IPR008397 Alginate lyase domain GO:0016829|GO:0042597 KEGG: 00051+4.2.2.3|MetaCyc: PWY-6986 TK78_RS09545 586019afad922ce7971653e98a15d0f5 401 Gene3D G3DSA:3.40.47.10 11 129 1.6E-73 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS09545 586019afad922ce7971653e98a15d0f5 401 Gene3D G3DSA:3.40.47.10 200 282 1.6E-73 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS09545 586019afad922ce7971653e98a15d0f5 401 SUPERFAMILY SSF53901 278 397 4.11E-35 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS09545 586019afad922ce7971653e98a15d0f5 401 ProSitePatterns PS00099 Thiolases active site. 380 393 - T 09-03-2017 IPR020610 Thiolase, active site GO:0008152|GO:0016747 TK78_RS09545 586019afad922ce7971653e98a15d0f5 401 ProSitePatterns PS00098 Thiolases acyl-enzyme intermediate signature. 90 108 - T 09-03-2017 IPR020615 Thiolase, acyl-enzyme intermediate active site GO:0008152|GO:0016747 TK78_RS09545 586019afad922ce7971653e98a15d0f5 401 Gene3D G3DSA:3.40.47.10 283 398 3.1E-54 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS09545 586019afad922ce7971653e98a15d0f5 401 Gene3D G3DSA:3.40.47.10 148 199 3.1E-54 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS09545 586019afad922ce7971653e98a15d0f5 401 Pfam PF02803 Thiolase, C-terminal domain 278 397 2.1E-44 T 09-03-2017 IPR020617 Thiolase, C-terminal GO:0008152|GO:0016747 TK78_RS09545 586019afad922ce7971653e98a15d0f5 401 SUPERFAMILY SSF53901 11 276 2.88E-85 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS09545 586019afad922ce7971653e98a15d0f5 401 PIRSF PIRSF000429 5 400 5.4E-120 T 09-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 TK78_RS09545 586019afad922ce7971653e98a15d0f5 401 ProSitePatterns PS00737 Thiolases signature 2. 345 361 - T 09-03-2017 IPR020613 Thiolase, conserved site GO:0008152|GO:0016747 TK78_RS09545 586019afad922ce7971653e98a15d0f5 401 Pfam PF00108 Thiolase, N-terminal domain 11 268 3.3E-95 T 09-03-2017 IPR020616 Thiolase, N-terminal GO:0008152|GO:0016747 TK78_RS09545 586019afad922ce7971653e98a15d0f5 401 TIGRFAM TIGR01930 AcCoA-C-Actrans: acetyl-CoA C-acyltransferase 12 396 1.5E-136 T 09-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 TK78_RS04095 a9b7f66e84ebc05954b837953069fc6f 269 Pfam PF13847 Methyltransferase domain 38 149 3.3E-26 T 09-03-2017 IPR025714 Methyltransferase domain TK78_RS04095 a9b7f66e84ebc05954b837953069fc6f 269 Gene3D G3DSA:3.40.50.150 7 260 2.9E-47 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS04095 a9b7f66e84ebc05954b837953069fc6f 269 SUPERFAMILY SSF53335 6 228 7.9E-46 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS24405 fe212fc1eefb2491edebbe953846f665 201 SUPERFAMILY SSF52096 18 189 1.53E-64 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS24405 fe212fc1eefb2491edebbe953846f665 201 Pfam PF00574 Clp protease 16 188 9.1E-75 T 09-03-2017 IPR023562 Clp protease proteolytic subunit /Translocation-enhancing protein TepA TK78_RS24405 fe212fc1eefb2491edebbe953846f665 201 Hamap MF_00444 ATP-dependent Clp protease proteolytic subunit [clpP]. 1 190 37.878 T 09-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TK78_RS24405 fe212fc1eefb2491edebbe953846f665 201 Gene3D G3DSA:3.90.226.10 17 188 1.1E-72 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS24405 fe212fc1eefb2491edebbe953846f665 201 PRINTS PR00127 Clp protease catalytic subunit P signature 165 184 1.1E-44 T 09-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TK78_RS24405 fe212fc1eefb2491edebbe953846f665 201 PRINTS PR00127 Clp protease catalytic subunit P signature 56 76 1.1E-44 T 09-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TK78_RS24405 fe212fc1eefb2491edebbe953846f665 201 PRINTS PR00127 Clp protease catalytic subunit P signature 17 32 1.1E-44 T 09-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TK78_RS24405 fe212fc1eefb2491edebbe953846f665 201 PRINTS PR00127 Clp protease catalytic subunit P signature 108 127 1.1E-44 T 09-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TK78_RS24405 fe212fc1eefb2491edebbe953846f665 201 PRINTS PR00127 Clp protease catalytic subunit P signature 87 104 1.1E-44 T 09-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TK78_RS27535 4b40a425e6e6ef4345534c1f2c392cc9 228 PRINTS PR00783 Major intrinsic protein family signature 163 185 1.4E-23 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS27535 4b40a425e6e6ef4345534c1f2c392cc9 228 PRINTS PR00783 Major intrinsic protein family signature 82 101 1.4E-23 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS27535 4b40a425e6e6ef4345534c1f2c392cc9 228 PRINTS PR00783 Major intrinsic protein family signature 45 69 1.4E-23 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS27535 4b40a425e6e6ef4345534c1f2c392cc9 228 PRINTS PR00783 Major intrinsic protein family signature 200 220 1.4E-23 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS27535 4b40a425e6e6ef4345534c1f2c392cc9 228 PRINTS PR00783 Major intrinsic protein family signature 2 21 1.4E-23 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS27535 4b40a425e6e6ef4345534c1f2c392cc9 228 Gene3D G3DSA:1.20.1080.10 4 216 2.5E-33 T 09-03-2017 IPR023271 Aquaporin-like Reactome: R-HSA-432047 TK78_RS27535 4b40a425e6e6ef4345534c1f2c392cc9 228 ProSitePatterns PS00221 MIP family signature. 63 71 - T 09-03-2017 IPR022357 Major intrinsic protein, conserved site GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS27535 4b40a425e6e6ef4345534c1f2c392cc9 228 SUPERFAMILY SSF81338 3 217 4.19E-34 T 09-03-2017 IPR023271 Aquaporin-like Reactome: R-HSA-432047 TK78_RS27535 4b40a425e6e6ef4345534c1f2c392cc9 228 Pfam PF00230 Major intrinsic protein 6 215 3.9E-30 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS31165 9f90c2b9585ecf8232e6380611f8855b 195 Gene3D G3DSA:1.10.286.10 18 56 9.3E-16 T 09-03-2017 TK78_RS31165 9f90c2b9585ecf8232e6380611f8855b 195 Pfam PF01227 GTP cyclohydrolase I 23 192 2.0E-50 T 09-03-2017 IPR020602 GTP cyclohydrolase I domain KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|Reactome: R-HSA-1474151 TK78_RS31165 9f90c2b9585ecf8232e6380611f8855b 195 Gene3D G3DSA:3.30.1130.10 70 193 3.5E-38 T 09-03-2017 TK78_RS31165 9f90c2b9585ecf8232e6380611f8855b 195 SUPERFAMILY SSF55620 12 193 3.93E-50 T 09-03-2017 TK78_RS31165 9f90c2b9585ecf8232e6380611f8855b 195 ProSitePatterns PS00860 GTP cyclohydrolase I signature 2. 121 131 - T 09-03-2017 IPR018234 GTP cyclohydrolase I, conserved site GO:0003934|GO:0005737|GO:0046654 KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|Reactome: R-HSA-1474151 TK78_RS30110 667bee8fd8fbdfc371d325442ad39fed 360 TIGRFAM TIGR00228 ruvC: crossover junction endodeoxyribonuclease RuvC 3 155 1.9E-34 T 09-03-2017 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 TK78_RS30110 667bee8fd8fbdfc371d325442ad39fed 360 PRINTS PR00696 Crossover junction endodeoxyribonuclease RUVC signature 62 78 1.6E-33 T 09-03-2017 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 TK78_RS30110 667bee8fd8fbdfc371d325442ad39fed 360 PRINTS PR00696 Crossover junction endodeoxyribonuclease RUVC signature 4 17 1.6E-33 T 09-03-2017 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 TK78_RS30110 667bee8fd8fbdfc371d325442ad39fed 360 PRINTS PR00696 Crossover junction endodeoxyribonuclease RUVC signature 108 127 1.6E-33 T 09-03-2017 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 TK78_RS30110 667bee8fd8fbdfc371d325442ad39fed 360 PRINTS PR00696 Crossover junction endodeoxyribonuclease RUVC signature 84 100 1.6E-33 T 09-03-2017 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 TK78_RS30110 667bee8fd8fbdfc371d325442ad39fed 360 PRINTS PR00696 Crossover junction endodeoxyribonuclease RUVC signature 140 152 1.6E-33 T 09-03-2017 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 TK78_RS30110 667bee8fd8fbdfc371d325442ad39fed 360 Pfam PF02075 Crossover junction endodeoxyribonuclease RuvC 3 152 2.1E-52 T 09-03-2017 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 TK78_RS30110 667bee8fd8fbdfc371d325442ad39fed 360 ProSitePatterns PS01321 Crossover junction endodeoxyribonuclease ruvC signature. 114 149 - T 09-03-2017 IPR020563 Crossover junction endodeoxyribonuclease RuvC, magnesium-binding site GO:0008821 TK78_RS30110 667bee8fd8fbdfc371d325442ad39fed 360 Hamap MF_00034 Crossover junction endodeoxyribonuclease RuvC [ruvC]. 1 155 45.423 T 09-03-2017 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 TK78_RS30110 667bee8fd8fbdfc371d325442ad39fed 360 SUPERFAMILY SSF53098 1 156 4.17E-44 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS30110 667bee8fd8fbdfc371d325442ad39fed 360 Gene3D G3DSA:3.30.420.10 1 156 4.9E-54 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS33680 135c9b4b16adf106fd5205300239eb77 595 Gene3D G3DSA:3.40.50.300 355 586 3.4E-53 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33680 135c9b4b16adf106fd5205300239eb77 595 Pfam PF00005 ABC transporter 372 521 1.3E-18 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS33680 135c9b4b16adf106fd5205300239eb77 595 SMART SM00382 381 566 1.5E-7 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS33680 135c9b4b16adf106fd5205300239eb77 595 SUPERFAMILY SSF52540 350 590 8.18E-62 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33680 135c9b4b16adf106fd5205300239eb77 595 Pfam PF00664 ABC transporter transmembrane region 36 307 5.7E-34 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS33680 135c9b4b16adf106fd5205300239eb77 595 Gene3D G3DSA:1.20.1560.10 23 336 5.1E-59 T 09-03-2017 TK78_RS33680 135c9b4b16adf106fd5205300239eb77 595 SUPERFAMILY SSF90123 23 336 1.7E-57 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS16665 f769385a25adcca4097df7f2a2f61088 248 SMART SM00862 170 244 5.3E-25 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS16665 f769385a25adcca4097df7f2a2f61088 248 SMART SM00448 21 132 4.0E-41 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS16665 f769385a25adcca4097df7f2a2f61088 248 Pfam PF00072 Response regulator receiver domain 23 132 3.1E-27 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS16665 f769385a25adcca4097df7f2a2f61088 248 Gene3D G3DSA:1.10.10.10 148 246 2.4E-34 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS16665 f769385a25adcca4097df7f2a2f61088 248 Gene3D G3DSA:3.40.50.2300 15 140 7.5E-40 T 09-03-2017 TK78_RS16665 f769385a25adcca4097df7f2a2f61088 248 SUPERFAMILY SSF46894 147 244 6.52E-29 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS16665 f769385a25adcca4097df7f2a2f61088 248 SUPERFAMILY SSF52172 17 140 1.71E-40 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS16665 f769385a25adcca4097df7f2a2f61088 248 Pfam PF00486 Transcriptional regulatory protein, C terminal 170 243 2.9E-24 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS21460 b54010124e4a2b22192d510db2262b8a 539 Pfam PF07690 Major Facilitator Superfamily 36 431 5.1E-49 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS21460 b54010124e4a2b22192d510db2262b8a 539 SUPERFAMILY SSF103473 485 514 1.24E-67 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS21460 b54010124e4a2b22192d510db2262b8a 539 SUPERFAMILY SSF103473 29 221 1.24E-67 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS21460 b54010124e4a2b22192d510db2262b8a 539 SUPERFAMILY SSF103473 270 440 1.24E-67 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS21460 b54010124e4a2b22192d510db2262b8a 539 Gene3D G3DSA:1.20.1250.20 29 210 6.3E-33 T 09-03-2017 TK78_RS21460 b54010124e4a2b22192d510db2262b8a 539 Gene3D G3DSA:1.20.1250.20 486 511 1.1E-21 T 09-03-2017 TK78_RS21460 b54010124e4a2b22192d510db2262b8a 539 Gene3D G3DSA:1.20.1250.20 284 441 1.1E-21 T 09-03-2017 TK78_RS15075 c8f429da256140ec26855c74043c8223 442 SUPERFAMILY SSF51419 18 281 1.28E-54 T 09-03-2017 IPR029066 PLP-binding barrel TK78_RS15075 c8f429da256140ec26855c74043c8223 442 SUPERFAMILY SSF50621 252 405 1.74E-26 T 09-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 TK78_RS15075 c8f429da256140ec26855c74043c8223 442 Gene3D G3DSA:3.20.20.10 30 264 2.3E-57 T 09-03-2017 IPR029066 PLP-binding barrel TK78_RS15075 c8f429da256140ec26855c74043c8223 442 Gene3D G3DSA:2.40.37.10 265 407 2.3E-24 T 09-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 TK78_RS15075 c8f429da256140ec26855c74043c8223 442 Pfam PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 284 402 6.9E-9 T 09-03-2017 IPR022643 Orn/DAP/Arg decarboxylase 2, C-terminal GO:0003824 TK78_RS15075 c8f429da256140ec26855c74043c8223 442 Pfam PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 29 279 4.8E-28 T 09-03-2017 IPR022644 Orn/DAP/Arg decarboxylase 2, N-terminal GO:0003824 TK78_RS15075 c8f429da256140ec26855c74043c8223 442 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 68 80 2.5E-5 T 09-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TK78_RS15075 c8f429da256140ec26855c74043c8223 442 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 269 288 2.5E-5 T 09-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TK78_RS15075 c8f429da256140ec26855c74043c8223 442 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 48 66 2.5E-5 T 09-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TK78_RS08060 c8ed550c05b5856a519d549c40b0d8a8 368 Hamap MF_01849 Dual-specificity RNA methyltransferase RlmN [rlmN]. 19 368 67.169 T 09-03-2017 IPR027492 Dual-specificity RNA methyltransferase RlmN GO:0030488|GO:0070475 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 TK78_RS08060 c8ed550c05b5856a519d549c40b0d8a8 368 Gene3D G3DSA:3.20.20.70 120 339 5.4E-16 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS08060 c8ed550c05b5856a519d549c40b0d8a8 368 SUPERFAMILY SSF102114 113 342 4.84E-17 T 09-03-2017 TK78_RS08060 c8ed550c05b5856a519d549c40b0d8a8 368 Pfam PF04055 Radical SAM superfamily 124 295 5.3E-16 T 09-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 TK78_RS08060 c8ed550c05b5856a519d549c40b0d8a8 368 PIRSF PIRSF006004 14 368 1.6E-124 T 09-03-2017 IPR004383 Ribosomal RNA large subunit methyltransferase RlmN/Cfr GO:0005737|GO:0006364|GO:0008173 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 TK78_RS08060 c8ed550c05b5856a519d549c40b0d8a8 368 TIGRFAM TIGR00048 rRNA_mod_RlmN: 23S rRNA (adenine(2503)-C(2))-methyltransferase 20 367 8.6E-97 T 09-03-2017 IPR004383 Ribosomal RNA large subunit methyltransferase RlmN/Cfr GO:0005737|GO:0006364|GO:0008173 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 TK78_RS24785 722136c3cb36a68d1418c9f5c25c6eb9 119 Pfam PF01230 HIT domain 17 112 1.4E-22 T 09-03-2017 IPR001310 Histidine triad (HIT) protein TK78_RS24785 722136c3cb36a68d1418c9f5c25c6eb9 119 Gene3D G3DSA:3.30.428.10 4 119 1.2E-36 T 09-03-2017 IPR011146 HIT-like domain GO:0003824 TK78_RS24785 722136c3cb36a68d1418c9f5c25c6eb9 119 SUPERFAMILY SSF54197 6 118 4.49E-33 T 09-03-2017 IPR011146 HIT-like domain GO:0003824 TK78_RS24785 722136c3cb36a68d1418c9f5c25c6eb9 119 PRINTS PR00332 Histidine triad family signature 10 26 1.4E-18 T 09-03-2017 IPR001310 Histidine triad (HIT) protein TK78_RS24785 722136c3cb36a68d1418c9f5c25c6eb9 119 PRINTS PR00332 Histidine triad family signature 99 109 1.4E-18 T 09-03-2017 IPR001310 Histidine triad (HIT) protein TK78_RS24785 722136c3cb36a68d1418c9f5c25c6eb9 119 PRINTS PR00332 Histidine triad family signature 31 49 1.4E-18 T 09-03-2017 IPR001310 Histidine triad (HIT) protein TK78_RS08705 1272f3d627d067058891eba6dfa10aea 355 Gene3D G3DSA:2.40.10.10 252 351 1.8E-22 T 09-03-2017 TK78_RS08705 1272f3d627d067058891eba6dfa10aea 355 Gene3D G3DSA:2.40.10.10 170 251 9.2E-29 T 09-03-2017 TK78_RS08705 1272f3d627d067058891eba6dfa10aea 355 SUPERFAMILY SSF50494 171 351 1.47E-36 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS08705 1272f3d627d067058891eba6dfa10aea 355 Gene3D G3DSA:3.30.300.50 96 163 1.4E-15 T 09-03-2017 TK78_RS08705 1272f3d627d067058891eba6dfa10aea 355 PIRSF PIRSF001134 1 355 3.0E-107 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS08705 1272f3d627d067058891eba6dfa10aea 355 Gene3D G3DSA:3.30.300.50 44 95 2.4E-8 T 09-03-2017 TK78_RS08705 1272f3d627d067058891eba6dfa10aea 355 Pfam PF02983 Alpha-lytic protease prodomain 97 152 3.7E-17 T 09-03-2017 IPR004236 Peptidase S1A, alpha-lytic prodomain GO:0005576|GO:0006508|GO:0008236 TK78_RS08705 1272f3d627d067058891eba6dfa10aea 355 ProSitePatterns PS00134 Serine proteases, trypsin family, histidine active site. 197 202 - T 09-03-2017 IPR018114 Serine proteases, trypsin family, histidine active site GO:0004252|GO:0006508 TK78_RS08705 1272f3d627d067058891eba6dfa10aea 355 ProSitePatterns PS00135 Serine proteases, trypsin family, serine active site. 305 316 - T 09-03-2017 IPR033116 Serine proteases, trypsin family, serine active site TK78_RS08705 1272f3d627d067058891eba6dfa10aea 355 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 195 209 4.5E-42 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS08705 1272f3d627d067058891eba6dfa10aea 355 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 320 334 4.5E-42 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS08705 1272f3d627d067058891eba6dfa10aea 355 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 277 294 4.5E-42 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS08705 1272f3d627d067058891eba6dfa10aea 355 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 296 319 4.5E-42 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS08705 1272f3d627d067058891eba6dfa10aea 355 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 256 276 4.5E-42 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS28330 57929e13acf3e8108765a2e101d45424 597 SUPERFAMILY SSF48208 194 591 6.8E-103 T 09-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 TK78_RS28330 57929e13acf3e8108765a2e101d45424 597 Gene3D G3DSA:1.50.10.10 215 591 1.5E-82 T 09-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 TK78_RS28330 57929e13acf3e8108765a2e101d45424 597 Pfam PF00723 Glycosyl hydrolases family 15 539 585 3.0E-6 T 09-03-2017 IPR011613 Glycoside hydrolase family 15/Phosphorylase b kinase regulatory chain family Reactome: R-HSA-70221 TK78_RS28330 57929e13acf3e8108765a2e101d45424 597 Pfam PF00723 Glycosyl hydrolases family 15 220 533 9.6E-64 T 09-03-2017 IPR011613 Glycoside hydrolase family 15/Phosphorylase b kinase regulatory chain family Reactome: R-HSA-70221 TK78_RS08715 0a3a474a46559e3b1ba09d0652c0b8e7 308 Gene3D G3DSA:3.20.20.220 34 302 1.4E-67 T 09-03-2017 IPR029041 FAD-linked oxidoreductase-like TK78_RS08715 0a3a474a46559e3b1ba09d0652c0b8e7 308 PIRSF PIRSF000196 1 308 4.6E-114 T 09-03-2017 IPR008219 Proline dehydrogenase GO:0004657|GO:0010133 KEGG: 00330+1.5.5.2|MetaCyc: PWY-5737|MetaCyc: PWY-6922 TK78_RS08715 0a3a474a46559e3b1ba09d0652c0b8e7 308 SUPERFAMILY SSF51730 35 304 1.77E-68 T 09-03-2017 IPR029041 FAD-linked oxidoreductase-like TK78_RS08715 0a3a474a46559e3b1ba09d0652c0b8e7 308 Pfam PF01619 Proline dehydrogenase 46 299 2.3E-30 T 09-03-2017 IPR002872 Proline dehydrogenase domain KEGG: 00330+1.5.5.2|MetaCyc: PWY-5737|MetaCyc: PWY-6922 TK78_RS26450 3611bacfe0b0aaa989a5dcfb3a876b0a 422 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 338 377 5.5E-5 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS26450 3611bacfe0b0aaa989a5dcfb3a876b0a 422 Pfam PF13796 Putative sensor 22 202 5.1E-17 T 09-03-2017 IPR025828 Putative sensor domain TK78_RS26450 3611bacfe0b0aaa989a5dcfb3a876b0a 422 SMART SM00387 331 421 0.0019 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS26450 3611bacfe0b0aaa989a5dcfb3a876b0a 422 Gene3D G3DSA:3.30.565.10 337 419 4.9E-8 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS26450 3611bacfe0b0aaa989a5dcfb3a876b0a 422 SUPERFAMILY SSF55874 331 418 5.75E-14 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS26450 3611bacfe0b0aaa989a5dcfb3a876b0a 422 Pfam PF07730 Histidine kinase 231 298 1.2E-15 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS11015 8c5784587993a4b2d5e67673ba01fbf5 385 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 192 373 1.3E-37 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS11015 8c5784587993a4b2d5e67673ba01fbf5 385 SMART SM00331 165 373 5.3E-20 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS11015 8c5784587993a4b2d5e67673ba01fbf5 385 Gene3D G3DSA:3.60.40.10 293 373 4.0E-5 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS11015 8c5784587993a4b2d5e67673ba01fbf5 385 SUPERFAMILY SSF81606 182 373 6.28E-12 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS28160 7cd47d7a47e39e0d83a1df5f1e1ba48c 171 Pfam PF01047 MarR family 50 106 1.2E-15 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS28160 7cd47d7a47e39e0d83a1df5f1e1ba48c 171 Gene3D G3DSA:1.10.10.10 23 155 5.7E-36 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS28160 7cd47d7a47e39e0d83a1df5f1e1ba48c 171 SMART SM00347 41 141 1.1E-20 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS28160 7cd47d7a47e39e0d83a1df5f1e1ba48c 171 ProSitePatterns PS01117 MarR-type HTH domain signature. 80 114 - T 09-03-2017 IPR023187 Transcriptional regulator MarR-type, conserved site TK78_RS28160 7cd47d7a47e39e0d83a1df5f1e1ba48c 171 SUPERFAMILY SSF46785 24 155 3.03E-33 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS28160 7cd47d7a47e39e0d83a1df5f1e1ba48c 171 PRINTS PR00598 Bacterial regulatory protein MarR family signature 131 151 2.7E-11 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS28160 7cd47d7a47e39e0d83a1df5f1e1ba48c 171 PRINTS PR00598 Bacterial regulatory protein MarR family signature 65 81 2.7E-11 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS28160 7cd47d7a47e39e0d83a1df5f1e1ba48c 171 PRINTS PR00598 Bacterial regulatory protein MarR family signature 82 97 2.7E-11 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS28160 7cd47d7a47e39e0d83a1df5f1e1ba48c 171 PRINTS PR00598 Bacterial regulatory protein MarR family signature 101 117 2.7E-11 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS14080 754d3f6b53c8b1109ec87fa8f0986365 395 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 281 387 5.0E-16 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS14080 754d3f6b53c8b1109ec87fa8f0986365 395 Pfam PF00672 HAMP domain 100 169 5.8E-12 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS14080 754d3f6b53c8b1109ec87fa8f0986365 395 SMART SM00304 119 172 3.6E-9 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS14080 754d3f6b53c8b1109ec87fa8f0986365 395 SUPERFAMILY SSF55874 243 387 4.85E-30 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS14080 754d3f6b53c8b1109ec87fa8f0986365 395 SUPERFAMILY SSF47384 156 236 4.51E-14 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS14080 754d3f6b53c8b1109ec87fa8f0986365 395 PRINTS PR00344 Bacterial sensor protein C-terminal signature 373 386 1.0E-10 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS14080 754d3f6b53c8b1109ec87fa8f0986365 395 PRINTS PR00344 Bacterial sensor protein C-terminal signature 332 342 1.0E-10 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS14080 754d3f6b53c8b1109ec87fa8f0986365 395 PRINTS PR00344 Bacterial sensor protein C-terminal signature 231 245 1.0E-10 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS14080 754d3f6b53c8b1109ec87fa8f0986365 395 PRINTS PR00344 Bacterial sensor protein C-terminal signature 349 367 1.0E-10 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS14080 754d3f6b53c8b1109ec87fa8f0986365 395 Gene3D G3DSA:3.30.565.10 243 391 9.6E-33 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS14080 754d3f6b53c8b1109ec87fa8f0986365 395 Gene3D G3DSA:1.10.287.130 163 234 1.2E-11 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS14080 754d3f6b53c8b1109ec87fa8f0986365 395 SUPERFAMILY SSF158472 120 170 7.32E-6 T 09-03-2017 TK78_RS14080 754d3f6b53c8b1109ec87fa8f0986365 395 SMART SM00387 281 389 4.2E-26 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS14080 754d3f6b53c8b1109ec87fa8f0986365 395 SMART SM00388 173 239 1.6E-12 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS14080 754d3f6b53c8b1109ec87fa8f0986365 395 Pfam PF00512 His Kinase A (phospho-acceptor) domain 173 238 5.1E-10 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS17740 2f24e0b5ea425e5a69d2e81400d09fbd 224 SUPERFAMILY SSF161111 18 204 7.72E-28 T 09-03-2017 TK78_RS17740 2f24e0b5ea425e5a69d2e81400d09fbd 224 Pfam PF01545 Cation efflux family 27 201 1.5E-12 T 09-03-2017 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 TK78_RS17740 2f24e0b5ea425e5a69d2e81400d09fbd 224 Gene3D G3DSA:1.20.1510.10 24 199 6.3E-16 T 09-03-2017 IPR027469 Cation efflux protein transmembrane domain TK78_RS15130 55264d8f42a774b8fce52c51f62cfd77 190 SUPERFAMILY SSF55811 17 176 1.11E-44 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS15130 55264d8f42a774b8fce52c51f62cfd77 190 Pfam PF00293 NUDIX domain 41 170 5.4E-26 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS15130 55264d8f42a774b8fce52c51f62cfd77 190 Hamap MF_00202 Isopentenyl-diphosphate Delta-isomerase [idi]. 14 185 30.586 T 09-03-2017 IPR011876 Isopentenyl-diphosphate delta-isomerase, type 1 GO:0004452|GO:0008299 KEGG: 00900+5.3.3.2|MetaCyc: PWY-5123|MetaCyc: PWY-6174|MetaCyc: PWY-6383|MetaCyc: PWY-6859|MetaCyc: PWY-7102|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-7560|MetaCyc: PWY-922|Reactome: R-HSA-191273 TK78_RS15130 55264d8f42a774b8fce52c51f62cfd77 190 Gene3D G3DSA:3.90.79.10 16 177 3.5E-48 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS15130 55264d8f42a774b8fce52c51f62cfd77 190 PIRSF PIRSF018427 5 187 2.3E-52 T 09-03-2017 IPR011876 Isopentenyl-diphosphate delta-isomerase, type 1 GO:0004452|GO:0008299 KEGG: 00900+5.3.3.2|MetaCyc: PWY-5123|MetaCyc: PWY-6174|MetaCyc: PWY-6383|MetaCyc: PWY-6859|MetaCyc: PWY-7102|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-7560|MetaCyc: PWY-922|Reactome: R-HSA-191273 TK78_RS15130 55264d8f42a774b8fce52c51f62cfd77 190 TIGRFAM TIGR02150 IPP_isom_1: isopentenyl-diphosphate delta-isomerase 18 172 2.4E-36 T 09-03-2017 IPR011876 Isopentenyl-diphosphate delta-isomerase, type 1 GO:0004452|GO:0008299 KEGG: 00900+5.3.3.2|MetaCyc: PWY-5123|MetaCyc: PWY-6174|MetaCyc: PWY-6383|MetaCyc: PWY-6859|MetaCyc: PWY-7102|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-7560|MetaCyc: PWY-922|Reactome: R-HSA-191273 TK78_RS16015 aee5183e12539219cfe84ba59c72e443 173 ProDom PD339375 PRECURSOR SIGNAL SCO3656 SCO2458 CGL2705 MB2629 RV2598/MT2673.1 4 167 2.0E-73 T 09-03-2017 IPR024486 Protein of unknown function DUF2617 TK78_RS16015 aee5183e12539219cfe84ba59c72e443 173 Pfam PF10936 Protein of unknown function DUF2617 3 164 9.6E-62 T 09-03-2017 IPR024486 Protein of unknown function DUF2617 TK78_RS10625 e425adf88e897e88412bffa250fb1cf8 528 Gene3D G3DSA:3.40.50.1820 211 335 1.9E-57 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS10625 e425adf88e897e88412bffa250fb1cf8 528 Gene3D G3DSA:3.40.50.1820 83 167 1.9E-57 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS10625 e425adf88e897e88412bffa250fb1cf8 528 Gene3D G3DSA:3.40.50.1820 394 515 1.9E-57 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS10625 e425adf88e897e88412bffa250fb1cf8 528 SUPERFAMILY SSF53474 97 165 2.99E-21 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS10625 e425adf88e897e88412bffa250fb1cf8 528 SUPERFAMILY SSF53474 209 489 2.99E-21 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS10625 e425adf88e897e88412bffa250fb1cf8 528 Pfam PF08386 TAP-like protein 423 527 3.2E-32 T 09-03-2017 IPR013595 Peptidase S33 tripeptidyl aminopeptidase-like, C-terminal TK78_RS25240 e88fee873ed356d0f22914b342232092 419 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 153 178 2.3E-15 T 09-03-2017 TK78_RS25240 e88fee873ed356d0f22914b342232092 419 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 240 254 2.3E-15 T 09-03-2017 TK78_RS25240 e88fee873ed356d0f22914b342232092 419 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 284 291 2.3E-15 T 09-03-2017 TK78_RS25240 e88fee873ed356d0f22914b342232092 419 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 7 29 2.3E-15 T 09-03-2017 TK78_RS25240 e88fee873ed356d0f22914b342232092 419 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 8 313 3.8E-65 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS25240 e88fee873ed356d0f22914b342232092 419 SUPERFAMILY SSF51905 153 323 4.78E-32 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS25240 e88fee873ed356d0f22914b342232092 419 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 153 171 1.7E-24 T 09-03-2017 TK78_RS25240 e88fee873ed356d0f22914b342232092 419 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 239 255 1.7E-24 T 09-03-2017 TK78_RS25240 e88fee873ed356d0f22914b342232092 419 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 8 27 1.7E-24 T 09-03-2017 TK78_RS25240 e88fee873ed356d0f22914b342232092 419 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 104 122 1.7E-24 T 09-03-2017 TK78_RS25240 e88fee873ed356d0f22914b342232092 419 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 269 291 1.7E-24 T 09-03-2017 TK78_RS25240 e88fee873ed356d0f22914b342232092 419 SUPERFAMILY SSF55424 325 419 5.36E-26 T 09-03-2017 IPR016156 FAD/NAD-linked reductase, dimerisation domain GO:0016491|GO:0050660|GO:0055114 TK78_RS25240 e88fee873ed356d0f22914b342232092 419 Gene3D G3DSA:3.50.50.60 113 323 3.0E-54 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS25240 e88fee873ed356d0f22914b342232092 419 SUPERFAMILY SSF51905 4 199 7.18E-46 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS25240 e88fee873ed356d0f22914b342232092 419 Gene3D G3DSA:3.50.50.60 4 112 2.9E-33 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS25240 e88fee873ed356d0f22914b342232092 419 Gene3D G3DSA:3.30.390.30 333 419 1.7E-29 T 09-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 TK78_RS25240 e88fee873ed356d0f22914b342232092 419 Pfam PF14759 Reductase C-terminal 333 419 6.3E-17 T 09-03-2017 IPR028202 Reductase, C-terminal TK78_RS01775 22263e00f3bc8bf3160fd77b00a23cd4 277 Pfam PF00005 ABC transporter 24 177 4.2E-24 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS01775 22263e00f3bc8bf3160fd77b00a23cd4 277 Gene3D G3DSA:3.40.50.300 9 247 1.5E-57 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01775 22263e00f3bc8bf3160fd77b00a23cd4 277 SUPERFAMILY SSF52540 7 242 1.04E-53 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01775 22263e00f3bc8bf3160fd77b00a23cd4 277 ProSitePatterns PS00211 ABC transporters family signature. 150 164 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS01775 22263e00f3bc8bf3160fd77b00a23cd4 277 SMART SM00382 31 257 3.1E-16 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS06460 ad9774a15dbae86906bb01e94e3307dd 119 SUPERFAMILY SSF101386 5 108 6.73E-35 T 09-03-2017 TK78_RS06460 ad9774a15dbae86906bb01e94e3307dd 119 Gene3D G3DSA:1.10.287.1080 3 98 7.4E-23 T 09-03-2017 TK78_RS06460 ad9774a15dbae86906bb01e94e3307dd 119 Pfam PF12643 MazG-like family 35 107 8.6E-12 T 09-03-2017 IPR025984 MazG-like domain KEGG: 00240+3.6.1.12|Reactome: R-HSA-499943 TK78_RS06460 ad9774a15dbae86906bb01e94e3307dd 119 PIRSF PIRSF029826 2 118 7.4E-41 T 09-03-2017 IPR011394 NTP Pyrophosphohydrolase MazG-related, RS21-C6 TK78_RS01955 1a54dd3e906631048a1527440db8c329 739 SUPERFAMILY SSF51695 453 500 1.26E-35 T 09-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 TK78_RS01955 1a54dd3e906631048a1527440db8c329 739 SUPERFAMILY SSF51695 537 732 1.26E-35 T 09-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 TK78_RS01955 1a54dd3e906631048a1527440db8c329 739 Gene3D G3DSA:3.20.20.190 538 732 7.3E-19 T 09-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 TK78_RS01955 1a54dd3e906631048a1527440db8c329 739 Gene3D G3DSA:3.20.20.190 461 501 7.3E-19 T 09-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 TK78_RS23795 cc3b1ace990ae6a5d810b1ae8da4b4c5 384 Gene3D G3DSA:3.20.20.70 54 325 9.2E-8 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS23795 cc3b1ace990ae6a5d810b1ae8da4b4c5 384 SUPERFAMILY SSF51569 52 330 3.54E-15 T 09-03-2017 TK78_RS23795 cc3b1ace990ae6a5d810b1ae8da4b4c5 384 Pfam PF06187 Protein of unknown function (DUF993) 27 381 2.8E-180 T 09-03-2017 IPR009334 Protein of unknown function DUF993 TK78_RS31335 b27a23341991d34c790955f45a9017a5 145 SUPERFAMILY SSF54637 5 143 6.4E-19 T 09-03-2017 IPR029069 HotDog domain TK78_RS31335 b27a23341991d34c790955f45a9017a5 145 Gene3D G3DSA:3.10.129.10 5 144 2.9E-38 T 09-03-2017 IPR029069 HotDog domain TK78_RS31335 b27a23341991d34c790955f45a9017a5 145 Pfam PF14539 Domain of unknown function (DUF4442) 6 140 2.0E-25 T 09-03-2017 IPR027961 Protein of unknown function DUF4442 TK78_RS15850 b5f331461eac860a5041e08b597ff7ef 219 SUPERFAMILY SSF48498 98 209 7.12E-8 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS15850 b5f331461eac860a5041e08b597ff7ef 219 ProSitePatterns PS01081 TetR-type HTH domain signature. 45 75 - T 09-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site TK78_RS15850 b5f331461eac860a5041e08b597ff7ef 219 SUPERFAMILY SSF46689 23 87 2.76E-12 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS15850 b5f331461eac860a5041e08b597ff7ef 219 Gene3D G3DSA:1.10.357.10 58 207 4.5E-20 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS15850 b5f331461eac860a5041e08b597ff7ef 219 Pfam PF13977 Bacterial transcriptional repressor 99 215 3.5E-8 T 09-03-2017 TK78_RS15850 b5f331461eac860a5041e08b597ff7ef 219 Pfam PF00440 Bacterial regulatory proteins, tetR family 32 78 3.6E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS15850 b5f331461eac860a5041e08b597ff7ef 219 Gene3D G3DSA:1.10.10.60 20 57 5.1E-11 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS13085 4abe2addbb73b521039dc3b0479ded9e 179 TIGRFAM TIGR03654 L6_bact: ribosomal protein uL6 2 177 1.5E-73 T 09-03-2017 IPR019906 Ribosomal protein L6, bacterial-type GO:0003735|GO:0005840|GO:0006412|GO:0019843 TK78_RS13085 4abe2addbb73b521039dc3b0479ded9e 179 Gene3D G3DSA:3.90.930.12 84 178 2.2E-38 T 09-03-2017 IPR020040 Ribosomal protein L6, alpha-beta domain GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13085 4abe2addbb73b521039dc3b0479ded9e 179 Gene3D G3DSA:3.90.930.12 2 83 1.5E-29 T 09-03-2017 IPR020040 Ribosomal protein L6, alpha-beta domain GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13085 4abe2addbb73b521039dc3b0479ded9e 179 Hamap MF_01365_B 50S ribosomal protein L6 [rplF]. 1 177 38.43 T 09-03-2017 IPR019906 Ribosomal protein L6, bacterial-type GO:0003735|GO:0005840|GO:0006412|GO:0019843 TK78_RS13085 4abe2addbb73b521039dc3b0479ded9e 179 ProSitePatterns PS00525 Ribosomal protein L6 signature 1. 155 163 - T 09-03-2017 IPR002358 Ribosomal protein L6, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13085 4abe2addbb73b521039dc3b0479ded9e 179 SUPERFAMILY SSF56053 84 177 1.8E-35 T 09-03-2017 IPR020040 Ribosomal protein L6, alpha-beta domain GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13085 4abe2addbb73b521039dc3b0479ded9e 179 PIRSF PIRSF002162 1 178 1.3E-48 T 09-03-2017 IPR000702 Ribosomal protein L6 GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13085 4abe2addbb73b521039dc3b0479ded9e 179 SUPERFAMILY SSF56053 1 83 1.05E-25 T 09-03-2017 IPR020040 Ribosomal protein L6, alpha-beta domain GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13085 4abe2addbb73b521039dc3b0479ded9e 179 Pfam PF00347 Ribosomal protein L6 92 165 2.4E-20 T 09-03-2017 IPR020040 Ribosomal protein L6, alpha-beta domain GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13085 4abe2addbb73b521039dc3b0479ded9e 179 Pfam PF00347 Ribosomal protein L6 11 83 4.3E-19 T 09-03-2017 IPR020040 Ribosomal protein L6, alpha-beta domain GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13085 4abe2addbb73b521039dc3b0479ded9e 179 PRINTS PR00059 Ribosomal protein L6 signature 72 97 1.4E-31 T 09-03-2017 IPR019906 Ribosomal protein L6, bacterial-type GO:0003735|GO:0005840|GO:0006412|GO:0019843 TK78_RS13085 4abe2addbb73b521039dc3b0479ded9e 179 PRINTS PR00059 Ribosomal protein L6 signature 142 163 1.4E-31 T 09-03-2017 IPR019906 Ribosomal protein L6, bacterial-type GO:0003735|GO:0005840|GO:0006412|GO:0019843 TK78_RS13085 4abe2addbb73b521039dc3b0479ded9e 179 PRINTS PR00059 Ribosomal protein L6 signature 100 116 1.4E-31 T 09-03-2017 IPR019906 Ribosomal protein L6, bacterial-type GO:0003735|GO:0005840|GO:0006412|GO:0019843 TK78_RS23390 af4d9b62570018f6a0ef754e26ef34cb 592 Pfam PF04183 IucA / IucC family 142 391 8.1E-80 T 09-03-2017 IPR007310 Aerobactin siderophore biosynthesis, IucA/IucC, N-terminal GO:0015343|GO:0019290 TK78_RS23390 af4d9b62570018f6a0ef754e26ef34cb 592 Pfam PF06276 Ferric iron reductase FhuF-like transporter 413 569 4.7E-39 T 09-03-2017 IPR022770 Ferric iron reductase FhuF domain TK78_RS13035 03c120b7618b137413117df807c01c3c 126 Pfam PF00416 Ribosomal protein S13/S18 3 109 6.2E-30 T 09-03-2017 IPR001892 Ribosomal protein S13 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13035 03c120b7618b137413117df807c01c3c 126 SUPERFAMILY SSF46946 2 122 2.75E-43 T 09-03-2017 IPR010979 Ribosomal protein S13-like, H2TH GO:0003676 TK78_RS13035 03c120b7618b137413117df807c01c3c 126 ProSitePatterns PS00646 Ribosomal protein S13 signature. 88 101 - T 09-03-2017 IPR018269 Ribosomal protein S13, conserved site GO:0003723|GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13035 03c120b7618b137413117df807c01c3c 126 Gene3D G3DSA:1.10.8.50 1 72 1.9E-29 T 09-03-2017 TK78_RS13035 03c120b7618b137413117df807c01c3c 126 Hamap MF_01315 30S ribosomal protein S13 [rpsM]. 1 120 27.157 T 09-03-2017 IPR001892 Ribosomal protein S13 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13035 03c120b7618b137413117df807c01c3c 126 PIRSF PIRSF002134 1 125 8.9E-42 T 09-03-2017 IPR001892 Ribosomal protein S13 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13035 03c120b7618b137413117df807c01c3c 126 TIGRFAM TIGR03631 uS13_bact: ribosomal protein uS13 3 115 3.5E-51 T 09-03-2017 IPR019980 Ribosomal protein S13, bacterial-type GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13035 03c120b7618b137413117df807c01c3c 126 Gene3D G3DSA:4.10.910.10 73 124 4.4E-25 T 09-03-2017 IPR027437 30s ribosomal protein S13, C-terminal Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS02935 3f8ad2d2a582f6c074fc700f2a828bf2 243 Pfam PF00456 Transketolase, thiamine diphosphate binding domain 38 226 1.2E-22 T 09-03-2017 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 TK78_RS02935 3f8ad2d2a582f6c074fc700f2a828bf2 243 SUPERFAMILY SSF52518 38 238 1.04E-45 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS02935 3f8ad2d2a582f6c074fc700f2a828bf2 243 Gene3D G3DSA:3.40.50.970 28 238 4.2E-45 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS32460 a7533d0d339de64920922a0e9d951b92 389 Gene3D G3DSA:3.40.50.2000 205 356 2.6E-25 T 09-03-2017 TK78_RS32460 a7533d0d339de64920922a0e9d951b92 389 Pfam PF13439 Glycosyltransferase Family 4 45 197 4.1E-15 T 09-03-2017 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 TK78_RS32460 a7533d0d339de64920922a0e9d951b92 389 Pfam PF00534 Glycosyl transferases group 1 205 356 2.2E-23 T 09-03-2017 IPR001296 Glycosyl transferase, family 1 TK78_RS32460 a7533d0d339de64920922a0e9d951b92 389 SUPERFAMILY SSF53756 41 375 7.85E-65 T 09-03-2017 TK78_RS09735 2c21df765da59d5116bc85849eb1c089 358 SMART SM00937 63 181 1.7E-53 T 09-03-2017 IPR005139 Peptide chain release factor GO:0005737|GO:0006415|GO:0016149 TK78_RS09735 2c21df765da59d5116bc85849eb1c089 358 Gene3D G3DSA:1.20.58.410 6 87 1.3E-16 T 09-03-2017 TK78_RS09735 2c21df765da59d5116bc85849eb1c089 358 Pfam PF00472 RF-1 domain 214 323 5.6E-40 T 09-03-2017 IPR000352 Peptide chain release factor class I/class II GO:0003747|GO:0006415 TK78_RS09735 2c21df765da59d5116bc85849eb1c089 358 TIGRFAM TIGR00019 prfA: peptide chain release factor 1 2 356 8.0E-149 T 09-03-2017 IPR004373 Peptide chain release factor 1 GO:0005737|GO:0006415|GO:0016149 TK78_RS09735 2c21df765da59d5116bc85849eb1c089 358 Pfam PF03462 PCRF domain 11 206 2.5E-67 T 09-03-2017 IPR005139 Peptide chain release factor GO:0005737|GO:0006415|GO:0016149 TK78_RS09735 2c21df765da59d5116bc85849eb1c089 358 SUPERFAMILY SSF75620 8 355 1.96E-126 T 09-03-2017 TK78_RS09735 2c21df765da59d5116bc85849eb1c089 358 Gene3D G3DSA:3.30.160.20 213 291 2.1E-33 T 09-03-2017 IPR014720 Double-stranded RNA-binding domain TK78_RS09735 2c21df765da59d5116bc85849eb1c089 358 ProSitePatterns PS00745 Prokaryotic-type class I peptide chain release factors signature. 230 246 - T 09-03-2017 IPR000352 Peptide chain release factor class I/class II GO:0003747|GO:0006415 TK78_RS09735 2c21df765da59d5116bc85849eb1c089 358 Hamap MF_00093 Peptide chain release factor 1 [prfA]. 1 358 37.467 T 09-03-2017 IPR004373 Peptide chain release factor 1 GO:0005737|GO:0006415|GO:0016149 TK78_RS00630 872379261d2402f53d3b4d14803b5a9e 109 Gene3D G3DSA:3.30.70.900 1 105 3.5E-35 T 09-03-2017 TK78_RS00630 872379261d2402f53d3b4d14803b5a9e 109 Pfam PF03992 Antibiotic biosynthesis monooxygenase 3 75 4.7E-16 T 09-03-2017 IPR007138 Antibiotic biosynthesis monooxygenase domain TK78_RS00630 872379261d2402f53d3b4d14803b5a9e 109 SUPERFAMILY SSF54909 1 102 3.18E-24 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS22195 fa54e9ad1c75ff51d38a20bf775c3858 1165 SUPERFAMILY SSF53756 924 1155 2.89E-11 T 09-03-2017 TK78_RS22195 fa54e9ad1c75ff51d38a20bf775c3858 1165 SUPERFAMILY SSF53448 3 221 1.88E-50 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS22195 fa54e9ad1c75ff51d38a20bf775c3858 1165 Pfam PF04464 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase 799 1154 4.6E-102 T 09-03-2017 IPR007554 CDP-glycerol glycerophosphotransferase GO:0016020|GO:0047355 TK78_RS22195 fa54e9ad1c75ff51d38a20bf775c3858 1165 Pfam PF00535 Glycosyl transferase family 2 6 169 5.4E-31 T 09-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 TK78_RS22195 fa54e9ad1c75ff51d38a20bf775c3858 1165 Gene3D G3DSA:3.90.550.10 2 194 1.6E-47 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS30125 cdfe526513af33da70b2145bae40f045 165 TIGRFAM TIGR00739 yajC: preprotein translocase, YajC subunit 4 82 9.4E-17 T 09-03-2017 IPR003849 Preprotein translocase YajC TK78_RS30125 cdfe526513af33da70b2145bae40f045 165 Pfam PF02699 Preprotein translocase subunit 5 79 1.2E-16 T 09-03-2017 IPR003849 Preprotein translocase YajC TK78_RS30125 cdfe526513af33da70b2145bae40f045 165 SMART SM01323 1 82 4.1E-22 T 09-03-2017 IPR003849 Preprotein translocase YajC TK78_RS01850 09407853018e38ade699f4795c1e0131 534 SUPERFAMILY SSF51556 259 471 6.43E-51 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS01850 09407853018e38ade699f4795c1e0131 534 SUPERFAMILY SSF51556 66 208 6.43E-51 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS01850 09407853018e38ade699f4795c1e0131 534 Gene3D G3DSA:3.20.20.140 74 474 1.2E-67 T 09-03-2017 TK78_RS01850 09407853018e38ade699f4795c1e0131 534 Pfam PF00962 Adenosine/AMP deaminase 185 469 3.0E-23 T 09-03-2017 IPR001365 Adenosine/AMP deaminase domain GO:0019239 Reactome: R-HSA-74217 TK78_RS32250 bc0867ddd891c14bf62d34a0ff6ca5e2 261 SUPERFAMILY SSF103473 16 246 5.1E-24 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS32250 bc0867ddd891c14bf62d34a0ff6ca5e2 261 Gene3D G3DSA:1.20.1250.20 48 246 6.4E-17 T 09-03-2017 TK78_RS32250 bc0867ddd891c14bf62d34a0ff6ca5e2 261 Pfam PF07690 Major Facilitator Superfamily 35 194 3.8E-11 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS21500 c1f76902aa5c176868dd08a39adf17a2 271 Pfam PF07510 Protein of unknown function (DUF1524) 133 266 3.7E-12 T 09-03-2017 IPR011089 Domain of unknown function DUF1524 TK78_RS30955 331a416487050a52d92ee710db05ee04 156 Gene3D G3DSA:2.30.110.10 10 151 6.0E-34 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS30955 331a416487050a52d92ee710db05ee04 156 SUPERFAMILY SSF50475 7 151 1.09E-30 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS30955 331a416487050a52d92ee710db05ee04 156 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 14 101 6.8E-15 T 09-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS27270 f766613fe7018dadf9af90c71fb64e2a 241 SUPERFAMILY SSF51366 4 237 1.26E-61 T 09-03-2017 IPR011060 Ribulose-phosphate binding barrel GO:0003824|GO:0008152 TK78_RS27270 f766613fe7018dadf9af90c71fb64e2a 241 Gene3D G3DSA:3.20.20.70 5 238 1.4E-69 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS27270 f766613fe7018dadf9af90c71fb64e2a 241 TIGRFAM TIGR01919 hisA-trpF: bifunctional HisA/TrpF protein 4 239 3.2E-118 T 09-03-2017 IPR010188 Bifunctional HisA/TrpF GO:0000105|GO:0000162|GO:0003949|GO:0004640|GO:0005737 KEGG: 00340+5.3.1.16 TK78_RS27270 f766613fe7018dadf9af90c71fb64e2a 241 Pfam PF00977 Histidine biosynthesis protein 6 231 1.6E-61 T 09-03-2017 IPR006062 Histidine biosynthesis GO:0000105 TK78_RS27270 f766613fe7018dadf9af90c71fb64e2a 241 Hamap MF_01014 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase [hisA]. 5 238 31.376 T 09-03-2017 IPR023016 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GO:0000105|GO:0003949 KEGG: 00340+5.3.1.16 TK78_RS25885 cc286bb3e99ee422eb620a6f13aee96f 206 Gene3D G3DSA:1.10.357.10 12 194 6.9E-31 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS25885 cc286bb3e99ee422eb620a6f13aee96f 206 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 44 67 3.8E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS25885 cc286bb3e99ee422eb620a6f13aee96f 206 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 23 36 3.8E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS25885 cc286bb3e99ee422eb620a6f13aee96f 206 Pfam PF00440 Bacterial regulatory proteins, tetR family 23 68 1.6E-15 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS25885 cc286bb3e99ee422eb620a6f13aee96f 206 SUPERFAMILY SSF46689 12 91 4.04E-18 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS31795 92a27a74fe3d2d532ed16b35866b32a2 286 Pfam PF02618 YceG-like family 55 274 4.8E-57 T 09-03-2017 IPR003770 Uncharacterised protein family UPF0755, YceG-like TK78_RS31795 92a27a74fe3d2d532ed16b35866b32a2 286 TIGRFAM TIGR00247 TIGR00247: conserved hypothetical protein, YceG family 90 276 6.2E-43 T 09-03-2017 IPR003770 Uncharacterised protein family UPF0755, YceG-like TK78_RS31795 92a27a74fe3d2d532ed16b35866b32a2 286 Gene3D G3DSA:3.30.160.60 250 278 9.7E-5 T 09-03-2017 IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain GO:0003676 TK78_RS20780 f42d0556a116836edb77878546310028 510 ProSitePatterns PS00216 Sugar transport proteins signature 1. 71 87 - T 09-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 TK78_RS20780 f42d0556a116836edb77878546310028 510 SUPERFAMILY SSF103473 6 201 1.07E-69 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS20780 f42d0556a116836edb77878546310028 510 SUPERFAMILY SSF103473 253 476 1.07E-69 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS20780 f42d0556a116836edb77878546310028 510 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 21 440 5.5E-81 T 09-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 TK78_RS20780 f42d0556a116836edb77878546310028 510 Pfam PF07690 Major Facilitator Superfamily 21 416 2.3E-55 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS20780 f42d0556a116836edb77878546310028 510 Gene3D G3DSA:1.20.1250.20 274 476 1.3E-14 T 09-03-2017 TK78_RS20780 f42d0556a116836edb77878546310028 510 Gene3D G3DSA:1.20.1250.20 11 203 6.7E-32 T 09-03-2017 TK78_RS20780 f42d0556a116836edb77878546310028 510 PRINTS PR01036 Tetracycline resistance protein TetB signature 142 166 1.1E-7 T 09-03-2017 TK78_RS20780 f42d0556a116836edb77878546310028 510 PRINTS PR01036 Tetracycline resistance protein TetB signature 80 102 1.1E-7 T 09-03-2017 TK78_RS20780 f42d0556a116836edb77878546310028 510 PRINTS PR01036 Tetracycline resistance protein TetB signature 208 226 1.1E-7 T 09-03-2017 TK78_RS20780 f42d0556a116836edb77878546310028 510 PRINTS PR01036 Tetracycline resistance protein TetB signature 20 44 1.1E-7 T 09-03-2017 TK78_RS03365 ec2d2e303a8b5239c28a21a2aed44574 138 Pfam PF04686 Streptomyces sporulation and cell division protein, SsgA 24 120 2.4E-29 T 09-03-2017 IPR006776 Sporulation-specific cell division protein SsgB GO:0051301 TK78_RS19420 e433901d62089f3fb81bd8d91c283ca8 536 Pfam PF02868 Thermolysin metallopeptidase, alpha-helical domain 361 535 1.3E-51 T 09-03-2017 IPR001570 Peptidase M4, C-terminal GO:0004222 TK78_RS19420 e433901d62089f3fb81bd8d91c283ca8 536 Gene3D G3DSA:3.10.170.10 211 362 2.1E-46 T 09-03-2017 IPR013856 Peptidase M4 domain GO:0004222 TK78_RS19420 e433901d62089f3fb81bd8d91c283ca8 536 SUPERFAMILY SSF55486 209 535 1.81E-80 T 09-03-2017 TK78_RS19420 e433901d62089f3fb81bd8d91c283ca8 536 Gene3D G3DSA:1.10.390.10 363 535 1.6E-50 T 09-03-2017 TK78_RS19420 e433901d62089f3fb81bd8d91c283ca8 536 Pfam PF01447 Thermolysin metallopeptidase, catalytic domain 211 358 5.5E-48 T 09-03-2017 IPR013856 Peptidase M4 domain GO:0004222 TK78_RS19420 e433901d62089f3fb81bd8d91c283ca8 536 Pfam PF07504 Fungalysin/Thermolysin Propeptide Motif 93 138 5.0E-16 T 09-03-2017 IPR011096 FTP domain TK78_RS19420 e433901d62089f3fb81bd8d91c283ca8 536 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 437 453 2.0E-18 T 09-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 TK78_RS19420 e433901d62089f3fb81bd8d91c283ca8 536 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 349 365 2.0E-18 T 09-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 TK78_RS19420 e433901d62089f3fb81bd8d91c283ca8 536 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 313 333 2.0E-18 T 09-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 TK78_RS19420 e433901d62089f3fb81bd8d91c283ca8 536 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 370 381 2.0E-18 T 09-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 TK78_RS19875 eef619ffb56dc218b3063b36e8599457 316 Pfam PF02541 Ppx/GppA phosphatase family 26 305 2.1E-70 T 09-03-2017 IPR003695 Ppx/GppA phosphatase KEGG: 00230+3.6.1.40 TK78_RS19875 eef619ffb56dc218b3063b36e8599457 316 SUPERFAMILY SSF53067 2 125 8.03E-30 T 09-03-2017 TK78_RS19875 eef619ffb56dc218b3063b36e8599457 316 Gene3D G3DSA:3.30.420.40 1 123 6.5E-33 T 09-03-2017 TK78_RS19875 eef619ffb56dc218b3063b36e8599457 316 Gene3D G3DSA:3.30.420.150 125 305 3.3E-49 T 09-03-2017 TK78_RS19875 eef619ffb56dc218b3063b36e8599457 316 SUPERFAMILY SSF53067 129 306 3.52E-38 T 09-03-2017 TK78_RS26095 14d9625a39ebe3361537c5e8d95f4134 331 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 137 195 1.0E-4 T 09-03-2017 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 TK78_RS26095 14d9625a39ebe3361537c5e8d95f4134 331 Gene3D G3DSA:3.40.50.720 1 144 7.1E-50 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS26095 14d9625a39ebe3361537c5e8d95f4134 331 Gene3D G3DSA:3.30.360.10 145 330 9.6E-55 T 09-03-2017 TK78_RS26095 14d9625a39ebe3361537c5e8d95f4134 331 SUPERFAMILY SSF55347 129 295 6.38E-43 T 09-03-2017 TK78_RS26095 14d9625a39ebe3361537c5e8d95f4134 331 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 6 121 3.6E-21 T 09-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 TK78_RS26095 14d9625a39ebe3361537c5e8d95f4134 331 SUPERFAMILY SSF51735 2 155 2.4E-51 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS06240 f40ca08ef7a9d08f55dd7a282ff8842f 489 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 248 255 - T 09-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 TK78_RS06240 f40ca08ef7a9d08f55dd7a282ff8842f 489 SUPERFAMILY SSF53720 3 479 1.24E-164 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS06240 f40ca08ef7a9d08f55dd7a282ff8842f 489 Gene3D G3DSA:3.40.309.10 263 442 9.2E-68 T 09-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 TK78_RS06240 f40ca08ef7a9d08f55dd7a282ff8842f 489 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 276 287 - T 09-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 TK78_RS06240 f40ca08ef7a9d08f55dd7a282ff8842f 489 Pfam PF00171 Aldehyde dehydrogenase family 10 476 1.1E-166 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS06240 f40ca08ef7a9d08f55dd7a282ff8842f 489 Gene3D G3DSA:3.40.605.10 4 262 1.8E-92 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS19055 04745bda4f2a5f6d3ca3976921020f7a 420 Pfam PF00512 His Kinase A (phospho-acceptor) domain 158 221 2.7E-11 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS19055 04745bda4f2a5f6d3ca3976921020f7a 420 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 270 383 9.5E-22 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS19055 04745bda4f2a5f6d3ca3976921020f7a 420 SMART SM00387 268 384 1.1E-37 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS19055 04745bda4f2a5f6d3ca3976921020f7a 420 PRINTS PR00344 Bacterial sensor protein C-terminal signature 327 337 9.3E-21 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS19055 04745bda4f2a5f6d3ca3976921020f7a 420 PRINTS PR00344 Bacterial sensor protein C-terminal signature 368 381 9.3E-21 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS19055 04745bda4f2a5f6d3ca3976921020f7a 420 PRINTS PR00344 Bacterial sensor protein C-terminal signature 344 362 9.3E-21 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS19055 04745bda4f2a5f6d3ca3976921020f7a 420 PRINTS PR00344 Bacterial sensor protein C-terminal signature 309 323 9.3E-21 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS19055 04745bda4f2a5f6d3ca3976921020f7a 420 Gene3D G3DSA:3.30.565.10 210 383 4.7E-45 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS19055 04745bda4f2a5f6d3ca3976921020f7a 420 SMART SM00388 157 223 2.1E-12 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS19055 04745bda4f2a5f6d3ca3976921020f7a 420 SUPERFAMILY SSF55874 213 382 3.54E-44 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS19055 04745bda4f2a5f6d3ca3976921020f7a 420 SUPERFAMILY SSF47384 140 223 1.24E-15 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS19055 04745bda4f2a5f6d3ca3976921020f7a 420 Gene3D G3DSA:1.10.287.130 149 209 2.0E-13 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS23965 5996b4a05c7d10b42c730efef02a4e46 237 SMART SM00421 166 223 3.2E-19 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS23965 5996b4a05c7d10b42c730efef02a4e46 237 Gene3D G3DSA:1.10.10.10 169 228 1.5E-25 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS23965 5996b4a05c7d10b42c730efef02a4e46 237 Pfam PF00072 Response regulator receiver domain 14 124 2.6E-29 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS23965 5996b4a05c7d10b42c730efef02a4e46 237 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 169 183 2.5E-10 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS23965 5996b4a05c7d10b42c730efef02a4e46 237 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 183 199 2.5E-10 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS23965 5996b4a05c7d10b42c730efef02a4e46 237 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 199 211 2.5E-10 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS23965 5996b4a05c7d10b42c730efef02a4e46 237 SUPERFAMILY SSF52172 11 141 3.7E-35 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS23965 5996b4a05c7d10b42c730efef02a4e46 237 ProSitePatterns PS00622 LuxR-type HTH domain signature. 183 210 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS23965 5996b4a05c7d10b42c730efef02a4e46 237 Gene3D G3DSA:3.40.50.2300 11 168 9.9E-41 T 09-03-2017 TK78_RS23965 5996b4a05c7d10b42c730efef02a4e46 237 Pfam PF00196 Bacterial regulatory proteins, luxR family 168 223 8.5E-16 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS23965 5996b4a05c7d10b42c730efef02a4e46 237 SMART SM00448 12 125 3.4E-33 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS23965 5996b4a05c7d10b42c730efef02a4e46 237 SUPERFAMILY SSF46894 157 229 7.82E-20 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS01770 a2441812b1345ae24e059d372c4cf129 147 PRINTS PR00294 Streptomyces subtilisin inhibitor signature 40 66 5.0E-22 T 09-03-2017 IPR000691 Proteinase inhibitor I16, Streptomyces subtilisin-type inhibitor GO:0004867 TK78_RS01770 a2441812b1345ae24e059d372c4cf129 147 PRINTS PR00294 Streptomyces subtilisin inhibitor signature 103 119 5.0E-22 T 09-03-2017 IPR000691 Proteinase inhibitor I16, Streptomyces subtilisin-type inhibitor GO:0004867 TK78_RS01770 a2441812b1345ae24e059d372c4cf129 147 PRINTS PR00294 Streptomyces subtilisin inhibitor signature 120 136 5.0E-22 T 09-03-2017 IPR000691 Proteinase inhibitor I16, Streptomyces subtilisin-type inhibitor GO:0004867 TK78_RS01770 a2441812b1345ae24e059d372c4cf129 147 SUPERFAMILY SSF55399 38 139 1.83E-35 T 09-03-2017 IPR023549 Subtilisin inhibitor GO:0004867 TK78_RS01770 a2441812b1345ae24e059d372c4cf129 147 Pfam PF00720 Subtilisin inhibitor-like 39 131 3.8E-37 T 09-03-2017 IPR023549 Subtilisin inhibitor GO:0004867 TK78_RS01770 a2441812b1345ae24e059d372c4cf129 147 Hamap MF_00778 Probable subtilase-type protease inhibitor [sti]. 38 147 29.328 T 09-03-2017 IPR000691 Proteinase inhibitor I16, Streptomyces subtilisin-type inhibitor GO:0004867 TK78_RS01770 a2441812b1345ae24e059d372c4cf129 147 Gene3D G3DSA:3.30.350.10 39 145 9.6E-37 T 09-03-2017 IPR023549 Subtilisin inhibitor GO:0004867 TK78_RS01770 a2441812b1345ae24e059d372c4cf129 147 ProDom PD004028 INHIBITOR PROTEASE SERINE DIRECT SEQUENCING SUBTILISIN PRECURSOR SIGNAL INHIBITOR-LIKE INHIBITOR 43 135 2.0E-27 T 09-03-2017 IPR023549 Subtilisin inhibitor GO:0004867 TK78_RS13510 71be41e904c8b52a8fe8eb5bddded703 254 ProSitePatterns PS00330 Hemolysin-type calcium-binding region signature. 223 241 - T 09-03-2017 IPR018511 Hemolysin-type calcium-binding conserved site TK78_RS13510 71be41e904c8b52a8fe8eb5bddded703 254 SUPERFAMILY SSF51120 111 249 6.93E-21 T 09-03-2017 IPR011049 Serralysin-like metalloprotease, C-terminal TK78_RS13510 71be41e904c8b52a8fe8eb5bddded703 254 Pfam PF00353 Haemolysin-type calcium-binding repeat (2 copies) 192 206 0.093 T 09-03-2017 IPR001343 Haemolysin-type calcium-binding repeat GO:0005509 TK78_RS13510 71be41e904c8b52a8fe8eb5bddded703 254 Pfam PF00353 Haemolysin-type calcium-binding repeat (2 copies) 132 139 11.0 T 09-03-2017 IPR001343 Haemolysin-type calcium-binding repeat GO:0005509 TK78_RS13510 71be41e904c8b52a8fe8eb5bddded703 254 Pfam PF00353 Haemolysin-type calcium-binding repeat (2 copies) 158 171 59.0 T 09-03-2017 IPR001343 Haemolysin-type calcium-binding repeat GO:0005509 TK78_RS13510 71be41e904c8b52a8fe8eb5bddded703 254 Pfam PF00353 Haemolysin-type calcium-binding repeat (2 copies) 209 225 0.031 T 09-03-2017 IPR001343 Haemolysin-type calcium-binding repeat GO:0005509 TK78_RS13510 71be41e904c8b52a8fe8eb5bddded703 254 Pfam PF00353 Haemolysin-type calcium-binding repeat (2 copies) 226 243 0.0027 T 09-03-2017 IPR001343 Haemolysin-type calcium-binding repeat GO:0005509 TK78_RS13510 71be41e904c8b52a8fe8eb5bddded703 254 PRINTS PR00313 NodO calcium binding signature 218 226 1.2E-9 T 09-03-2017 TK78_RS13510 71be41e904c8b52a8fe8eb5bddded703 254 PRINTS PR00313 NodO calcium binding signature 236 245 1.2E-9 T 09-03-2017 TK78_RS13510 71be41e904c8b52a8fe8eb5bddded703 254 PRINTS PR00313 NodO calcium binding signature 129 140 1.2E-9 T 09-03-2017 TK78_RS13510 71be41e904c8b52a8fe8eb5bddded703 254 PRINTS PR00313 NodO calcium binding signature 182 190 1.2E-9 T 09-03-2017 TK78_RS13510 71be41e904c8b52a8fe8eb5bddded703 254 Gene3D G3DSA:2.150.10.10 114 251 4.9E-28 T 09-03-2017 IPR011049 Serralysin-like metalloprotease, C-terminal TK78_RS02865 84b7a2b1bd934567b9c99f9343bbed0c 230 Gene3D G3DSA:3.40.50.2300 17 173 2.3E-38 T 09-03-2017 TK78_RS02865 84b7a2b1bd934567b9c99f9343bbed0c 230 Pfam PF00072 Response regulator receiver domain 20 131 7.0E-29 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS02865 84b7a2b1bd934567b9c99f9343bbed0c 230 ProSitePatterns PS00622 LuxR-type HTH domain signature. 182 209 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS02865 84b7a2b1bd934567b9c99f9343bbed0c 230 Gene3D G3DSA:1.10.10.10 174 229 1.2E-24 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS02865 84b7a2b1bd934567b9c99f9343bbed0c 230 SUPERFAMILY SSF46894 164 229 1.73E-21 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS02865 84b7a2b1bd934567b9c99f9343bbed0c 230 SMART SM00448 18 131 1.9E-31 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS02865 84b7a2b1bd934567b9c99f9343bbed0c 230 Pfam PF00196 Bacterial regulatory proteins, luxR family 168 222 1.0E-17 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS02865 84b7a2b1bd934567b9c99f9343bbed0c 230 SMART SM00421 165 222 9.0E-23 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS02865 84b7a2b1bd934567b9c99f9343bbed0c 230 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 182 198 6.6E-14 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS02865 84b7a2b1bd934567b9c99f9343bbed0c 230 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 168 182 6.6E-14 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS02865 84b7a2b1bd934567b9c99f9343bbed0c 230 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 198 210 6.6E-14 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS02865 84b7a2b1bd934567b9c99f9343bbed0c 230 SUPERFAMILY SSF52172 17 139 3.56E-34 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS05090 b395419a55aa7575ae5aa545507ee4fd 558 Gene3D G3DSA:2.30.38.10 366 442 3.1E-18 T 09-03-2017 TK78_RS05090 b395419a55aa7575ae5aa545507ee4fd 558 Pfam PF00501 AMP-binding enzyme 48 448 2.9E-73 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS05090 b395419a55aa7575ae5aa545507ee4fd 558 Pfam PF13193 AMP-binding enzyme C-terminal domain 457 534 1.8E-18 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS05090 b395419a55aa7575ae5aa545507ee4fd 558 Gene3D G3DSA:3.30.300.30 443 543 9.4E-22 T 09-03-2017 TK78_RS05090 b395419a55aa7575ae5aa545507ee4fd 558 SUPERFAMILY SSF56801 16 543 2.35E-127 T 09-03-2017 TK78_RS05090 b395419a55aa7575ae5aa545507ee4fd 558 Gene3D G3DSA:3.40.50.980 207 365 1.0E-24 T 09-03-2017 TK78_RS05090 b395419a55aa7575ae5aa545507ee4fd 558 Gene3D G3DSA:3.40.50.980 50 206 5.4E-25 T 09-03-2017 TK78_RS07490 d03b33f0bfa3eb7957f468f0556cef88 249 Gene3D G3DSA:1.10.10.10 137 181 2.4E-6 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS07490 d03b33f0bfa3eb7957f468f0556cef88 249 Pfam PF02631 RecX family 113 233 1.2E-27 T 09-03-2017 IPR003783 Regulatory protein RecX GO:0006282 TK78_RS07490 d03b33f0bfa3eb7957f468f0556cef88 249 Gene3D G3DSA:1.10.10.10 91 135 2.5E-4 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS07490 d03b33f0bfa3eb7957f468f0556cef88 249 Hamap MF_01114 Regulatory protein RecX [recX]. 82 238 15.454 T 09-03-2017 IPR003783 Regulatory protein RecX GO:0006282 TK78_RS30975 cf4901ad64242403bdae67ad0210cc5d 237 Pfam PF13529 Peptidase_C39 like family 72 211 3.4E-18 T 09-03-2017 TK78_RS30975 cf4901ad64242403bdae67ad0210cc5d 237 SUPERFAMILY SSF54001 56 230 5.69E-7 T 09-03-2017 TK78_RS08020 1259d0adf5e00070179fe398bb305998 151 Pfam PF08327 Activator of Hsp90 ATPase homolog 1-like protein 16 147 1.1E-24 T 09-03-2017 IPR013538 Activator of Hsp90 ATPase homologue 1-like GO:0006950 TK78_RS08020 1259d0adf5e00070179fe398bb305998 151 SUPERFAMILY SSF55961 9 149 9.73E-34 T 09-03-2017 TK78_RS08020 1259d0adf5e00070179fe398bb305998 151 Gene3D G3DSA:3.30.530.20 9 149 6.2E-35 T 09-03-2017 IPR023393 START-like domain TK78_RS33015 c560eb0d7154fc169c643c7e1d020f4b 217 Gene3D G3DSA:3.40.50.150 17 189 5.7E-33 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS33015 c560eb0d7154fc169c643c7e1d020f4b 217 Pfam PF13649 Methyltransferase domain 54 145 3.2E-19 T 09-03-2017 TK78_RS33015 c560eb0d7154fc169c643c7e1d020f4b 217 SUPERFAMILY SSF53335 17 201 2.09E-32 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS29595 fc22a2ce7f0c1e994ec46525d86c4b0a 281 SMART SM00967 33 112 1.3E-10 T 09-03-2017 IPR013123 RNA 2-O ribose methyltransferase, substrate binding GO:0008168 TK78_RS29595 fc22a2ce7f0c1e994ec46525d86c4b0a 281 Pfam PF08032 RNA 2'-O ribose methyltransferase substrate binding 34 109 2.7E-9 T 09-03-2017 IPR013123 RNA 2-O ribose methyltransferase, substrate binding GO:0008168 TK78_RS29595 fc22a2ce7f0c1e994ec46525d86c4b0a 281 SUPERFAMILY SSF75217 105 274 9.81E-41 T 09-03-2017 IPR029028 Alpha/beta knot methyltransferases TK78_RS29595 fc22a2ce7f0c1e994ec46525d86c4b0a 281 Gene3D G3DSA:3.40.1280.10 119 274 2.9E-48 T 09-03-2017 IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal TK78_RS29595 fc22a2ce7f0c1e994ec46525d86c4b0a 281 Pfam PF00588 SpoU rRNA Methylase family 123 267 3.3E-36 T 09-03-2017 IPR001537 tRNA/rRNA methyltransferase, SpoU type GO:0003723|GO:0006396|GO:0008173 TK78_RS29595 fc22a2ce7f0c1e994ec46525d86c4b0a 281 Gene3D G3DSA:3.30.1330.30 6 108 2.7E-27 T 09-03-2017 IPR029064 50S ribosomal protein L30e-like TK78_RS29595 fc22a2ce7f0c1e994ec46525d86c4b0a 281 SUPERFAMILY SSF55315 6 108 7.3E-19 T 09-03-2017 IPR029064 50S ribosomal protein L30e-like TK78_RS02555 ae67d00f3071433c373362be6a8126c4 117 Gene3D G3DSA:3.40.630.30 7 93 4.9E-19 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS02555 ae67d00f3071433c373362be6a8126c4 117 SUPERFAMILY SSF55729 8 94 6.03E-20 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS02555 ae67d00f3071433c373362be6a8126c4 117 Pfam PF14542 GCN5-related N-acetyl-transferase 23 93 1.3E-17 T 09-03-2017 IPR031165 Yjdj-type Gcn5-related N-acetyltransferase TK78_RS31000 4c8a09bca81a70a374c60ac15c70d86b 144 ProSitePatterns PS01029 Dehydroquinase class II signature. 7 24 - T 09-03-2017 IPR018509 Dehydroquinase, class II, conserved site GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 TK78_RS31000 4c8a09bca81a70a374c60ac15c70d86b 144 SUPERFAMILY SSF52304 3 141 4.71E-49 T 09-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 TK78_RS31000 4c8a09bca81a70a374c60ac15c70d86b 144 Pfam PF01220 Dehydroquinase class II 3 138 3.8E-45 T 09-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 TK78_RS31000 4c8a09bca81a70a374c60ac15c70d86b 144 Hamap MF_00169 3-dehydroquinate dehydratase [aroQ]. 1 144 49.802 T 09-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 TK78_RS31000 4c8a09bca81a70a374c60ac15c70d86b 144 PIRSF PIRSF001399 1 144 2.4E-49 T 09-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 TK78_RS31000 4c8a09bca81a70a374c60ac15c70d86b 144 ProDom PD004527 LYASE II 3-DEHYDROQUINATE BIOSYNTHESIS DEHYDRATASE TYPE 3-DEHYDROQUINASE DHQASE AMINO AROMATIC 17 139 9.0E-51 T 09-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 TK78_RS31000 4c8a09bca81a70a374c60ac15c70d86b 144 Gene3D G3DSA:3.40.50.9100 3 140 1.2E-48 T 09-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 TK78_RS11670 d043544d3c0be080b40e9e2761ce1f49 491 TIGRFAM TIGR00791 gntP: transporter, gluconate:H+ symporter (GntP) family 30 491 4.6E-119 T 09-03-2017 IPR003474 Gluconate transporter GO:0015128|GO:0016020|GO:0035429 TK78_RS11670 d043544d3c0be080b40e9e2761ce1f49 491 Pfam PF02447 GntP family permease 30 490 3.6E-130 T 09-03-2017 IPR003474 Gluconate transporter GO:0015128|GO:0016020|GO:0035429 TK78_RS11670 d043544d3c0be080b40e9e2761ce1f49 491 PIRSF PIRSF002746 24 491 4.4E-165 T 09-03-2017 IPR003474 Gluconate transporter GO:0015128|GO:0016020|GO:0035429 TK78_RS19520 674bb63016c59d70f1a9f02973dc9aa3 80 Pfam PF04149 Domain of unknown function (DUF397) 17 69 6.0E-18 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS29110 35e59ec170a84f03bec8bcca4d0d8841 311 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 147 168 - T 09-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 TK78_RS29110 35e59ec170a84f03bec8bcca4d0d8841 311 SMART SM00829 10 305 2.6E-28 T 09-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 TK78_RS29110 35e59ec170a84f03bec8bcca4d0d8841 311 SUPERFAMILY SSF50129 1 152 1.37E-36 T 09-03-2017 IPR011032 GroES-like TK78_RS29110 35e59ec170a84f03bec8bcca4d0d8841 311 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 27 90 4.2E-7 T 09-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 TK78_RS29110 35e59ec170a84f03bec8bcca4d0d8841 311 Gene3D G3DSA:3.90.180.10 1 152 4.8E-48 T 09-03-2017 IPR011032 GroES-like TK78_RS29110 35e59ec170a84f03bec8bcca4d0d8841 311 SUPERFAMILY SSF51735 119 242 4.34E-38 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS29110 35e59ec170a84f03bec8bcca4d0d8841 311 Gene3D G3DSA:3.40.50.720 153 241 2.6E-22 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS29110 35e59ec170a84f03bec8bcca4d0d8841 311 Pfam PF13602 Zinc-binding dehydrogenase 193 305 4.0E-21 T 09-03-2017 TK78_RS01160 2df476d1379c4d33cac98112f170b921 410 Gene3D G3DSA:3.60.21.10 177 355 1.8E-23 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS01160 2df476d1379c4d33cac98112f170b921 410 SUPERFAMILY SSF56300 172 404 1.25E-35 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS01160 2df476d1379c4d33cac98112f170b921 410 Pfam PF00149 Calcineurin-like phosphoesterase 178 345 9.2E-9 T 09-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 TK78_RS20145 edcfa834e38ff3e6ec5ae24efd49771a 225 Pfam PF13419 Haloacid dehalogenase-like hydrolase 20 197 7.4E-22 T 09-03-2017 IPR023214 HAD-like domain TK78_RS20145 edcfa834e38ff3e6ec5ae24efd49771a 225 SUPERFAMILY SSF56784 18 200 9.1E-41 T 09-03-2017 IPR023214 HAD-like domain TK78_RS20145 edcfa834e38ff3e6ec5ae24efd49771a 225 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 92 194 1.1E-11 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS20145 edcfa834e38ff3e6ec5ae24efd49771a 225 Gene3D G3DSA:3.40.50.1000 102 217 8.0E-37 T 09-03-2017 IPR023214 HAD-like domain TK78_RS20145 edcfa834e38ff3e6ec5ae24efd49771a 225 Gene3D G3DSA:3.40.50.1000 7 30 8.0E-37 T 09-03-2017 IPR023214 HAD-like domain TK78_RS26835 b53fc1e690df0531622848aa5dc79055 342 Pfam PF00877 NlpC/P60 family 243 329 3.9E-27 T 09-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain TK78_RS26835 b53fc1e690df0531622848aa5dc79055 342 SUPERFAMILY SSF54001 226 332 2.31E-38 T 09-03-2017 TK78_RS26835 b53fc1e690df0531622848aa5dc79055 342 Gene3D G3DSA:3.90.1720.10 225 332 1.1E-41 T 09-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain TK78_RS10170 03fb109625b38e7e99ba77a0184aa211 328 Gene3D G3DSA:3.40.50.720 3 296 8.1E-19 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS10170 03fb109625b38e7e99ba77a0184aa211 328 SUPERFAMILY SSF51735 2 275 9.41E-30 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS10170 03fb109625b38e7e99ba77a0184aa211 328 Pfam PF01370 NAD dependent epimerase/dehydratase family 1 202 2.2E-5 T 09-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 TK78_RS08160 179e0f9363eaf3ca3d97e4b62113912e 202 Gene3D G3DSA:2.30.30.240 96 166 3.5E-18 T 09-03-2017 TK78_RS08160 179e0f9363eaf3ca3d97e4b62113912e 202 SUPERFAMILY SSF50346 96 166 1.86E-16 T 09-03-2017 IPR011033 PRC-barrel-like TK78_RS08160 179e0f9363eaf3ca3d97e4b62113912e 202 SUPERFAMILY SSF50447 3 85 6.36E-18 T 09-03-2017 IPR009000 Translation protein, beta-barrel domain TK78_RS08160 179e0f9363eaf3ca3d97e4b62113912e 202 Pfam PF01782 RimM N-terminal domain 5 83 5.0E-23 T 09-03-2017 IPR002676 RimM protein GO:0006364 TK78_RS08160 179e0f9363eaf3ca3d97e4b62113912e 202 TIGRFAM TIGR02273 16S_RimM: 16S rRNA processing protein RimM 3 166 2.3E-43 T 09-03-2017 IPR011961 16S rRNA processing protein RimM GO:0005840|GO:0006364|GO:0043022 TK78_RS08160 179e0f9363eaf3ca3d97e4b62113912e 202 Gene3D G3DSA:2.40.30.60 3 90 1.3E-21 T 09-03-2017 IPR002676 RimM protein GO:0006364 TK78_RS08160 179e0f9363eaf3ca3d97e4b62113912e 202 Pfam PF05239 PRC-barrel domain 93 166 1.5E-8 T 09-03-2017 IPR027275 PRC-barrel domain TK78_RS08160 179e0f9363eaf3ca3d97e4b62113912e 202 Hamap MF_00014 Ribosome maturation factor RimM [rimM]. 2 166 23.315 T 09-03-2017 IPR011961 16S rRNA processing protein RimM GO:0005840|GO:0006364|GO:0043022 TK78_RS20930 5461f4d2e208a30ec7ea4dda472c40a2 355 Gene3D G3DSA:2.70.70.10 167 307 1.2E-10 T 09-03-2017 TK78_RS20930 5461f4d2e208a30ec7ea4dda472c40a2 355 Pfam PF01551 Peptidase family M23 226 306 4.6E-7 T 09-03-2017 IPR016047 Peptidase M23 TK78_RS20930 5461f4d2e208a30ec7ea4dda472c40a2 355 SUPERFAMILY SSF51261 163 306 1.41E-8 T 09-03-2017 IPR011055 Duplicated hybrid motif TK78_RS16105 e9886a431ffee3be52f36240d289e5f2 755 Gene3D G3DSA:1.10.1060.10 279 335 1.1E-31 T 09-03-2017 TK78_RS16105 e9886a431ffee3be52f36240d289e5f2 755 Gene3D G3DSA:1.10.1060.10 372 422 1.1E-31 T 09-03-2017 TK78_RS16105 e9886a431ffee3be52f36240d289e5f2 755 Pfam PF02754 Cysteine-rich domain 616 703 1.9E-19 T 09-03-2017 IPR004017 Cysteine-rich domain TK78_RS16105 e9886a431ffee3be52f36240d289e5f2 755 Pfam PF02754 Cysteine-rich domain 478 577 8.6E-14 T 09-03-2017 IPR004017 Cysteine-rich domain TK78_RS16105 e9886a431ffee3be52f36240d289e5f2 755 SUPERFAMILY SSF46548 375 421 4.19E-21 T 09-03-2017 IPR009051 Alpha-helical ferredoxin GO:0051536 TK78_RS16105 e9886a431ffee3be52f36240d289e5f2 755 SUPERFAMILY SSF46548 287 338 4.19E-21 T 09-03-2017 IPR009051 Alpha-helical ferredoxin GO:0051536 TK78_RS16105 e9886a431ffee3be52f36240d289e5f2 755 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 302 313 - T 09-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TK78_RS16105 e9886a431ffee3be52f36240d289e5f2 755 Pfam PF13183 4Fe-4S dicluster domain 299 407 2.6E-14 T 09-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TK78_RS16105 e9886a431ffee3be52f36240d289e5f2 755 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 393 404 - T 09-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TK78_RS29280 240074dc0cef2fea09b43d3dd4624d6b 263 Gene3D G3DSA:1.20.1080.10 6 262 8.9E-82 T 09-03-2017 IPR023271 Aquaporin-like Reactome: R-HSA-432047 TK78_RS29280 240074dc0cef2fea09b43d3dd4624d6b 263 ProSitePatterns PS00221 MIP family signature. 65 73 - T 09-03-2017 IPR022357 Major intrinsic protein, conserved site GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS29280 240074dc0cef2fea09b43d3dd4624d6b 263 TIGRFAM TIGR00861 MIP: MIP family channel proteins 10 258 3.0E-51 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS29280 240074dc0cef2fea09b43d3dd4624d6b 263 PRINTS PR00783 Major intrinsic protein family signature 161 179 6.3E-42 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS29280 240074dc0cef2fea09b43d3dd4624d6b 263 PRINTS PR00783 Major intrinsic protein family signature 47 71 6.3E-42 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS29280 240074dc0cef2fea09b43d3dd4624d6b 263 PRINTS PR00783 Major intrinsic protein family signature 5 24 6.3E-42 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS29280 240074dc0cef2fea09b43d3dd4624d6b 263 PRINTS PR00783 Major intrinsic protein family signature 241 261 6.3E-42 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS29280 240074dc0cef2fea09b43d3dd4624d6b 263 PRINTS PR00783 Major intrinsic protein family signature 194 216 6.3E-42 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS29280 240074dc0cef2fea09b43d3dd4624d6b 263 PRINTS PR00783 Major intrinsic protein family signature 84 103 6.3E-42 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS29280 240074dc0cef2fea09b43d3dd4624d6b 263 Pfam PF00230 Major intrinsic protein 6 258 2.7E-43 T 09-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 TK78_RS29280 240074dc0cef2fea09b43d3dd4624d6b 263 SUPERFAMILY SSF81338 7 262 8.76E-64 T 09-03-2017 IPR023271 Aquaporin-like Reactome: R-HSA-432047 TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 600 733 4.8E-18 T 09-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 879 1009 4.2E-19 T 09-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 SUPERFAMILY SSF51126 227 413 2.12E-11 T 09-03-2017 IPR011050 Pectin lyase fold/virulence factor TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 Pfam PF13229 Right handed beta helix region 410 503 7.9E-7 T 09-03-2017 TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 Pfam PF13229 Right handed beta helix region 158 309 1.3E-18 T 09-03-2017 TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 SUPERFAMILY SSF52540 559 798 2.13E-37 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 SUPERFAMILY SSF51126 5 230 2.98E-30 T 09-03-2017 IPR011050 Pectin lyase fold/virulence factor TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 PRINTS PR00819 CbxX/CfqX superfamily signature 960 972 1.2E-51 T 09-03-2017 IPR000641 CbxX/CfqX GO:0005524 TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 PRINTS PR00819 CbxX/CfqX superfamily signature 837 851 1.2E-51 T 09-03-2017 IPR000641 CbxX/CfqX GO:0005524 TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 PRINTS PR00819 CbxX/CfqX superfamily signature 915 929 1.2E-51 T 09-03-2017 IPR000641 CbxX/CfqX GO:0005524 TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 PRINTS PR00819 CbxX/CfqX superfamily signature 998 1017 1.2E-51 T 09-03-2017 IPR000641 CbxX/CfqX GO:0005524 TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 PRINTS PR00819 CbxX/CfqX superfamily signature 1055 1067 1.2E-51 T 09-03-2017 IPR000641 CbxX/CfqX GO:0005524 TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 PRINTS PR00819 CbxX/CfqX superfamily signature 877 892 1.2E-51 T 09-03-2017 IPR000641 CbxX/CfqX GO:0005524 TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 PRINTS PR00819 CbxX/CfqX superfamily signature 929 948 1.2E-51 T 09-03-2017 IPR000641 CbxX/CfqX GO:0005524 TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 PRINTS PR00819 CbxX/CfqX superfamily signature 981 998 1.2E-51 T 09-03-2017 IPR000641 CbxX/CfqX GO:0005524 TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 SMART SM00710 462 484 3200.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 SMART SM00710 370 392 320.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 SMART SM00710 416 438 40.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 SMART SM00710 211 232 6800.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 SMART SM00710 347 369 5100.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 SMART SM00710 233 255 140.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 SMART SM00710 279 301 2200.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 SMART SM00710 142 164 1800.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 SMART SM00710 165 187 370.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 SMART SM00710 302 324 2000.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 SMART SM00710 119 141 72.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 SMART SM00710 256 278 52.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 SMART SM00710 188 210 3500.0 T 09-03-2017 IPR006626 Parallel beta-helix repeat TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 Gene3D G3DSA:2.160.20.10 11 227 6.7E-21 T 09-03-2017 IPR012334 Pectin lyase fold TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 Gene3D G3DSA:2.160.20.10 228 291 7.2E-12 T 09-03-2017 IPR012334 Pectin lyase fold TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 Gene3D G3DSA:2.160.20.10 396 533 7.2E-12 T 09-03-2017 IPR012334 Pectin lyase fold TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 SUPERFAMILY SSF52540 836 1075 5.94E-36 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 SMART SM00382 874 1013 1.0E-9 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 SMART SM00382 595 736 7.6E-7 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 Gene3D G3DSA:3.40.50.300 836 1025 2.8E-28 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 Gene3D G3DSA:3.40.50.300 559 749 9.7E-29 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31895 a30403c58e793a4dfaa0dcaf1f6d52bd 1103 SUPERFAMILY SSF51126 331 534 7.63E-11 T 09-03-2017 IPR011050 Pectin lyase fold/virulence factor TK78_RS25815 94d84b54a9603caea31e4f1104dc106c 489 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 255 262 - T 09-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 TK78_RS25815 94d84b54a9603caea31e4f1104dc106c 489 Gene3D G3DSA:3.40.309.10 270 446 1.3E-60 T 09-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 TK78_RS25815 94d84b54a9603caea31e4f1104dc106c 489 Pfam PF00171 Aldehyde dehydrogenase family 24 479 2.7E-148 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS25815 94d84b54a9603caea31e4f1104dc106c 489 SUPERFAMILY SSF53720 7 483 4.71E-150 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS25815 94d84b54a9603caea31e4f1104dc106c 489 Gene3D G3DSA:3.40.605.10 12 269 7.9E-84 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS10615 144ed4c2f5e70c9eece7dff5ea96acdb 160 Pfam PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 29 90 3.9E-18 T 09-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 TK78_RS10615 144ed4c2f5e70c9eece7dff5ea96acdb 160 Gene3D G3DSA:1.10.10.10 28 87 5.8E-14 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS10615 144ed4c2f5e70c9eece7dff5ea96acdb 160 SUPERFAMILY SSF46767 28 88 1.27E-14 T 09-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 TK78_RS34820 6caa870fbc10edd6892d3472163c267f 235 Pfam PF10138 vWA found in TerF C terminus 21 232 6.0E-17 T 09-03-2017 IPR019303 vWA found in TerF C terminus TK78_RS32050 cfa68282530efddfee1d790acdfae999 312 TIGRFAM TIGR00027 mthyl_TIGR00027: methyltransferase, TIGR00027 family 23 282 1.2E-74 T 09-03-2017 IPR011610 S-adenosyl-L-methionine-dependent methyltransferase, putative GO:0008168 TK78_RS32050 cfa68282530efddfee1d790acdfae999 312 Gene3D G3DSA:3.40.50.150 26 220 4.6E-16 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS32050 cfa68282530efddfee1d790acdfae999 312 Pfam PF04072 Leucine carboxyl methyltransferase 25 205 1.1E-48 T 09-03-2017 IPR007213 Methyltransferase Ppm1/Ppm2/Tcmp GO:0008168|GO:0032259 TK78_RS32050 cfa68282530efddfee1d790acdfae999 312 SUPERFAMILY SSF53335 21 302 1.49E-63 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS06085 7166a76e8c298cb1a0462ed90674cfc4 217 Pfam PF06736 Protein of unknown function (DUF1211) 18 106 5.5E-21 T 09-03-2017 IPR010617 Endosomal/lysomomal potassium channel TMEM175 GO:0005267 TK78_RS07150 55b212cec5e265b62a87a9ef00b020c2 328 Gene3D G3DSA:3.40.50.720 2 176 7.6E-47 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07150 55b212cec5e265b62a87a9ef00b020c2 328 Pfam PF01370 NAD dependent epimerase/dehydratase family 4 245 5.0E-56 T 09-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 TK78_RS07150 55b212cec5e265b62a87a9ef00b020c2 328 Gene3D G3DSA:3.90.25.10 177 320 7.6E-37 T 09-03-2017 TK78_RS07150 55b212cec5e265b62a87a9ef00b020c2 328 SUPERFAMILY SSF51735 2 320 1.69E-81 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS15155 c3bbef7a51386b70f9009aec533ff859 591 SUPERFAMILY SSF90123 21 328 1.83E-36 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS15155 c3bbef7a51386b70f9009aec533ff859 591 Pfam PF00664 ABC transporter transmembrane region 54 293 2.5E-14 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS15155 c3bbef7a51386b70f9009aec533ff859 591 ProSitePatterns PS00211 ABC transporters family signature. 481 495 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS15155 c3bbef7a51386b70f9009aec533ff859 591 Pfam PF00005 ABC transporter 397 509 2.0E-10 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS15155 c3bbef7a51386b70f9009aec533ff859 591 Gene3D G3DSA:3.40.50.300 395 572 2.8E-32 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15155 c3bbef7a51386b70f9009aec533ff859 591 Gene3D G3DSA:1.20.1560.10 51 327 9.5E-27 T 09-03-2017 TK78_RS15155 c3bbef7a51386b70f9009aec533ff859 591 SUPERFAMILY SSF52540 395 576 1.05E-28 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS04310 c1a457a5348c76fbe69fe50ee9d2d06b 66 Pfam PF09957 Bacterial antitoxin of type II TA system, VapB 3 44 8.3E-6 T 09-03-2017 IPR019239 Bacterial antitoxin of type II TA system, VapB TK78_RS05165 845acd2ec352f569042e48106cf7c6e2 458 Gene3D G3DSA:3.20.20.30 350 439 2.7E-137 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS05165 845acd2ec352f569042e48106cf7c6e2 458 Gene3D G3DSA:3.20.20.30 5 308 2.7E-137 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS05165 845acd2ec352f569042e48106cf7c6e2 458 TIGRFAM TIGR03860 FMN_nitrolo: FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family 12 432 5.3E-169 T 09-03-2017 IPR016215 Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A GO:0004497 TK78_RS05165 845acd2ec352f569042e48106cf7c6e2 458 PIRSF PIRSF000337 5 446 2.3E-165 T 09-03-2017 IPR016215 Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A GO:0004497 TK78_RS05165 845acd2ec352f569042e48106cf7c6e2 458 SUPERFAMILY SSF51679 7 438 2.49E-129 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS05165 845acd2ec352f569042e48106cf7c6e2 458 Pfam PF00296 Luciferase-like monooxygenase 30 388 7.5E-60 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS26345 97136813039203a325e05be8269a1556 313 Gene3D G3DSA:3.90.210.10 182 287 3.7E-17 T 09-03-2017 TK78_RS26345 97136813039203a325e05be8269a1556 313 SUPERFAMILY SSF56399 180 284 1.32E-17 T 09-03-2017 TK78_RS12130 0c3369ef6a77bcb8e70edaa44c94e54e 317 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 61 72 1.3E-6 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS12130 0c3369ef6a77bcb8e70edaa44c94e54e 317 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 40 51 1.3E-6 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS12130 0c3369ef6a77bcb8e70edaa44c94e54e 317 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 51 61 1.3E-6 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS12130 0c3369ef6a77bcb8e70edaa44c94e54e 317 Gene3D G3DSA:1.10.10.10 27 107 3.2E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS12130 0c3369ef6a77bcb8e70edaa44c94e54e 317 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 27 84 1.9E-20 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS12130 0c3369ef6a77bcb8e70edaa44c94e54e 317 SUPERFAMILY SSF46785 27 106 1.79E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS12130 0c3369ef6a77bcb8e70edaa44c94e54e 317 Gene3D G3DSA:3.40.190.10 198 285 4.0E-31 T 09-03-2017 TK78_RS12130 0c3369ef6a77bcb8e70edaa44c94e54e 317 Pfam PF03466 LysR substrate binding domain 110 310 3.7E-50 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS12130 0c3369ef6a77bcb8e70edaa44c94e54e 317 Gene3D G3DSA:3.40.190.10 112 197 6.7E-23 T 09-03-2017 TK78_RS12130 0c3369ef6a77bcb8e70edaa44c94e54e 317 SUPERFAMILY SSF53850 111 315 1.21E-43 T 09-03-2017 TK78_RS11170 c48b675316a0a7ce392db587aa2c96ae 291 Hamap MF_01282 Virginiamycin B lyase [vgb]. 5 291 43.31 T 09-03-2017 IPR011217 Streptogramin lyase GO:0000287|GO:0016835|GO:0017001|GO:0046677 TK78_RS11170 c48b675316a0a7ce392db587aa2c96ae 291 PIRSF PIRSF026412 3 291 1.2E-103 T 09-03-2017 IPR011217 Streptogramin lyase GO:0000287|GO:0016835|GO:0017001|GO:0046677 TK78_RS11170 c48b675316a0a7ce392db587aa2c96ae 291 Gene3D G3DSA:2.120.10.30 7 161 6.3E-30 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS11170 c48b675316a0a7ce392db587aa2c96ae 291 Gene3D G3DSA:2.120.10.30 203 280 6.3E-30 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS11170 c48b675316a0a7ce392db587aa2c96ae 291 SUPERFAMILY SSF101898 49 281 3.66E-33 T 09-03-2017 TK78_RS00675 4846cc28dac2d43b4d50210797ccf05d 295 Gene3D G3DSA:3.40.50.10490 31 147 1.3E-15 T 09-03-2017 TK78_RS00675 4846cc28dac2d43b4d50210797ccf05d 295 SUPERFAMILY SSF53697 25 289 9.96E-41 T 09-03-2017 TK78_RS00675 4846cc28dac2d43b4d50210797ccf05d 295 Gene3D G3DSA:3.40.50.10490 170 289 4.5E-28 T 09-03-2017 TK78_RS10045 232c10223740c1dcc454285e9302a2ea 477 Pfam PF00150 Cellulase (glycosyl hydrolase family 5) 72 362 1.5E-26 T 09-03-2017 IPR001547 Glycoside hydrolase, family 5 GO:0004553|GO:0005975 TK78_RS10045 232c10223740c1dcc454285e9302a2ea 477 Gene3D G3DSA:3.20.20.80 183 367 1.0E-47 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS10045 232c10223740c1dcc454285e9302a2ea 477 Gene3D G3DSA:3.20.20.80 39 150 1.0E-47 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS10045 232c10223740c1dcc454285e9302a2ea 477 SUPERFAMILY SSF51445 181 366 4.9E-47 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS10045 232c10223740c1dcc454285e9302a2ea 477 SUPERFAMILY SSF51445 46 147 4.9E-47 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS27410 8a61947d0afacf6e6254c77a1bcf3f6e 1519 Pfam PF01645 Conserved region in glutamate synthase 815 1178 3.9E-157 T 09-03-2017 IPR002932 Glutamate synthase domain GO:0006537|GO:0015930|GO:0016638|GO:0055114 TK78_RS27410 8a61947d0afacf6e6254c77a1bcf3f6e 1519 Pfam PF01493 GXGXG motif 1263 1441 5.1E-75 T 09-03-2017 IPR002489 Glutamate synthase, alpha subunit, C-terminal GO:0008152|GO:0016491|GO:0055114 TK78_RS27410 8a61947d0afacf6e6254c77a1bcf3f6e 1519 SUPERFAMILY SSF51395 449 1214 3.34E-263 T 09-03-2017 TK78_RS27410 8a61947d0afacf6e6254c77a1bcf3f6e 1519 Pfam PF04898 Glutamate synthase central domain 462 750 2.8E-111 T 09-03-2017 IPR006982 Glutamate synthase, central-N GO:0006807|GO:0015930|GO:0055114 TK78_RS27410 8a61947d0afacf6e6254c77a1bcf3f6e 1519 SUPERFAMILY SSF56235 28 437 7.08E-149 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS27410 8a61947d0afacf6e6254c77a1bcf3f6e 1519 Gene3D G3DSA:2.160.20.60 1233 1507 4.6E-102 T 09-03-2017 IPR002489 Glutamate synthase, alpha subunit, C-terminal GO:0008152|GO:0016491|GO:0055114 TK78_RS27410 8a61947d0afacf6e6254c77a1bcf3f6e 1519 Gene3D G3DSA:3.20.20.70 828 1210 1.2E-180 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS27410 8a61947d0afacf6e6254c77a1bcf3f6e 1519 Pfam PF00310 Glutamine amidotransferases class-II 28 435 1.6E-180 T 09-03-2017 IPR017932 Glutamine amidotransferase type 2 domain TK78_RS27410 8a61947d0afacf6e6254c77a1bcf3f6e 1519 Gene3D G3DSA:3.20.20.70 445 802 4.9E-103 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS27410 8a61947d0afacf6e6254c77a1bcf3f6e 1519 Gene3D G3DSA:3.60.20.10 28 444 1.8E-187 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS27410 8a61947d0afacf6e6254c77a1bcf3f6e 1519 SUPERFAMILY SSF69336 1227 1492 6.54E-87 T 09-03-2017 IPR002489 Glutamate synthase, alpha subunit, C-terminal GO:0008152|GO:0016491|GO:0055114 TK78_RS23650 3fda8a0c0a38c85e6957ca7755eeff32 89 Gene3D G3DSA:2.40.30.100 2 86 4.8E-35 T 09-03-2017 TK78_RS23650 3fda8a0c0a38c85e6957ca7755eeff32 89 Pfam PF08922 Domain of unknown function (DUF1905) 5 83 2.8E-27 T 09-03-2017 IPR015018 Protein of unknown function DUF1905 TK78_RS23650 3fda8a0c0a38c85e6957ca7755eeff32 89 SUPERFAMILY SSF141694 2 85 4.71E-28 T 09-03-2017 TK78_RS24100 255a705ebfbc093bba00b0847d532a33 468 Gene3D G3DSA:2.60.200.20 368 465 4.7E-21 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS24100 255a705ebfbc093bba00b0847d532a33 468 SMART SM00240 379 439 9.1E-5 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS24100 255a705ebfbc093bba00b0847d532a33 468 Pfam PF00498 FHA domain 380 458 1.7E-14 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS24100 255a705ebfbc093bba00b0847d532a33 468 SUPERFAMILY SSF49879 326 463 1.34E-21 T 09-03-2017 IPR008984 SMAD/FHA domain GO:0005515 TK78_RS17440 82410ba174aabf7ade169f2df4d01e8e 467 SMART SM00220 9 258 2.6E-36 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS17440 82410ba174aabf7ade169f2df4d01e8e 467 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 123 135 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS17440 82410ba174aabf7ade169f2df4d01e8e 467 Gene3D G3DSA:1.10.510.10 91 258 1.4E-37 T 09-03-2017 TK78_RS17440 82410ba174aabf7ade169f2df4d01e8e 467 Gene3D G3DSA:1.10.510.10 292 359 1.4E-37 T 09-03-2017 TK78_RS17440 82410ba174aabf7ade169f2df4d01e8e 467 SUPERFAMILY SSF56112 347 358 4.32E-61 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS17440 82410ba174aabf7ade169f2df4d01e8e 467 SUPERFAMILY SSF56112 5 263 4.32E-61 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS17440 82410ba174aabf7ade169f2df4d01e8e 467 Pfam PF00069 Protein kinase domain 9 248 2.1E-37 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS17440 82410ba174aabf7ade169f2df4d01e8e 467 Gene3D G3DSA:3.30.200.20 4 90 1.9E-14 T 09-03-2017 TK78_RS01605 c1319f6e5f0bd36cb5460e72d1a77167 349 SUPERFAMILY SSF48576 58 348 9.28E-73 T 09-03-2017 IPR008949 Isoprenoid synthase domain TK78_RS01605 c1319f6e5f0bd36cb5460e72d1a77167 349 Gene3D G3DSA:1.10.600.10 58 348 9.8E-79 T 09-03-2017 IPR008949 Isoprenoid synthase domain TK78_RS01605 c1319f6e5f0bd36cb5460e72d1a77167 349 Pfam PF00348 Polyprenyl synthetase 58 291 8.2E-51 T 09-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 TK78_RS16260 7b7ef044e1ad442fb1ba078dbcd3ccfa 224 PIRSF PIRSF010219 7 224 2.0E-66 T 09-03-2017 IPR016566 Uncharacterised conserved protein UCP010219 TK78_RS16260 7b7ef044e1ad442fb1ba078dbcd3ccfa 224 Pfam PF11361 Protein of unknown function (DUF3159) 33 216 2.5E-61 T 09-03-2017 IPR016566 Uncharacterised conserved protein UCP010219 TK78_RS31780 55854a06e86c85aad3732892614eb8c9 139 Gene3D G3DSA:1.10.10.10 2 136 1.0E-33 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS31780 55854a06e86c85aad3732892614eb8c9 139 SMART SM00347 19 120 2.0E-24 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS31780 55854a06e86c85aad3732892614eb8c9 139 Pfam PF01047 MarR family 26 85 6.6E-12 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS31780 55854a06e86c85aad3732892614eb8c9 139 PRINTS PR00598 Bacterial regulatory protein MarR family signature 61 76 1.1E-10 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS31780 55854a06e86c85aad3732892614eb8c9 139 PRINTS PR00598 Bacterial regulatory protein MarR family signature 80 96 1.1E-10 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS31780 55854a06e86c85aad3732892614eb8c9 139 PRINTS PR00598 Bacterial regulatory protein MarR family signature 110 130 1.1E-10 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS31780 55854a06e86c85aad3732892614eb8c9 139 SUPERFAMILY SSF46785 2 134 3.17E-30 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS01975 5059d88758e5d3c50d1031017baaaf86 525 Gene3D G3DSA:2.30.40.10 6 121 5.4E-16 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS01975 5059d88758e5d3c50d1031017baaaf86 525 SUPERFAMILY SSF51338 481 519 9.26E-19 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS01975 5059d88758e5d3c50d1031017baaaf86 525 SUPERFAMILY SSF51338 4 57 9.26E-19 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS01975 5059d88758e5d3c50d1031017baaaf86 525 Pfam PF07969 Amidohydrolase family 45 519 2.0E-79 T 09-03-2017 IPR013108 Amidohydrolase 3 TK78_RS01975 5059d88758e5d3c50d1031017baaaf86 525 Gene3D G3DSA:3.20.20.140 179 466 5.6E-35 T 09-03-2017 TK78_RS01975 5059d88758e5d3c50d1031017baaaf86 525 Gene3D G3DSA:2.30.40.10 467 503 3.5E-5 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS01975 5059d88758e5d3c50d1031017baaaf86 525 SUPERFAMILY SSF51556 172 481 2.52E-27 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS01975 5059d88758e5d3c50d1031017baaaf86 525 SUPERFAMILY SSF51556 56 114 2.52E-27 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS04890 278b81e3125d525a35502c63380ca321 226 SUPERFAMILY SSF52540 3 221 3.43E-65 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS04890 278b81e3125d525a35502c63380ca321 226 Pfam PF00005 ABC transporter 22 171 5.5E-34 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS04890 278b81e3125d525a35502c63380ca321 226 ProSitePatterns PS00211 ABC transporters family signature. 143 157 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS04890 278b81e3125d525a35502c63380ca321 226 SMART SM00382 31 219 1.6E-14 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS04890 278b81e3125d525a35502c63380ca321 226 Gene3D G3DSA:3.40.50.300 3 221 2.6E-67 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17885 10332c0138e1af08add631d15e3a17d6 323 ProSitePatterns PS00211 ABC transporters family signature. 138 152 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS17885 10332c0138e1af08add631d15e3a17d6 323 SUPERFAMILY SSF52540 6 228 4.91E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17885 10332c0138e1af08add631d15e3a17d6 323 TIGRFAM TIGR01188 drrA: daunorubicin resistance ABC transporter, ATP-binding protein 14 316 8.9E-112 T 09-03-2017 IPR005894 Daunorubicin resistance ABC transporter ATP-binding subunit DrrA GO:0005524|GO:0043215|GO:1900753 TK78_RS17885 10332c0138e1af08add631d15e3a17d6 323 Pfam PF00005 ABC transporter 23 165 3.8E-27 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS17885 10332c0138e1af08add631d15e3a17d6 323 SMART SM00382 31 220 1.0E-11 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS17885 10332c0138e1af08add631d15e3a17d6 323 Gene3D G3DSA:3.40.50.300 3 231 3.3E-67 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS30425 768781fc975e7495d1382b599175cc22 402 Gene3D G3DSA:3.20.20.40 118 400 1.4E-87 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS30425 768781fc975e7495d1382b599175cc22 402 SUPERFAMILY SSF51989 119 400 3.53E-84 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS30425 768781fc975e7495d1382b599175cc22 402 PRINTS PR00733 Glycosyl hydrolase family 6 signature 209 224 4.3E-38 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS30425 768781fc975e7495d1382b599175cc22 402 PRINTS PR00733 Glycosyl hydrolase family 6 signature 329 342 4.3E-38 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS30425 768781fc975e7495d1382b599175cc22 402 PRINTS PR00733 Glycosyl hydrolase family 6 signature 138 157 4.3E-38 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS30425 768781fc975e7495d1382b599175cc22 402 PRINTS PR00733 Glycosyl hydrolase family 6 signature 369 383 4.3E-38 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS30425 768781fc975e7495d1382b599175cc22 402 PRINTS PR00733 Glycosyl hydrolase family 6 signature 345 365 4.3E-38 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS30425 768781fc975e7495d1382b599175cc22 402 PRINTS PR00733 Glycosyl hydrolase family 6 signature 296 306 4.3E-38 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS30425 768781fc975e7495d1382b599175cc22 402 PRINTS PR00733 Glycosyl hydrolase family 6 signature 181 194 4.3E-38 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS30425 768781fc975e7495d1382b599175cc22 402 PRINTS PR00733 Glycosyl hydrolase family 6 signature 265 278 4.3E-38 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS30425 768781fc975e7495d1382b599175cc22 402 ProSitePatterns PS00656 Glycosyl hydrolases family 6 signature 2. 226 235 - T 09-03-2017 IPR001524 Glycoside hydrolase, family 6, conserved site GO:0004553|GO:0005975 TK78_RS30425 768781fc975e7495d1382b599175cc22 402 Pfam PF01341 Glycosyl hydrolases family 6 143 387 1.3E-66 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS12165 de6740e29bdb145759e497177f49bd8d 425 PIRSF PIRSF000478 1 423 9.3E-153 T 09-03-2017 IPR000053 Thymidine/pyrimidine-nucleoside phosphorylase GO:0004645|GO:0006206 Reactome: R-HSA-73614|Reactome: R-HSA-73621 TK78_RS12165 de6740e29bdb145759e497177f49bd8d 425 SMART SM00941 334 408 5.2E-34 T 09-03-2017 IPR013102 Pyrimidine nucleoside phosphorylase, C-terminal GO:0006213|GO:0016763 Reactome: R-HSA-73614|Reactome: R-HSA-73621 TK78_RS12165 de6740e29bdb145759e497177f49bd8d 425 TIGRFAM TIGR02644 Y_phosphoryl: pyrimidine-nucleoside phosphorylase 4 407 3.3E-168 T 09-03-2017 IPR018090 Pyrimidine-nucleoside phosphorylase, bacterial/eukaryotic GO:0006213|GO:0016154 KEGG: 00240+2.4.2.4|KEGG: 00983+2.4.2.4|MetaCyc: PWY-7181|Reactome: R-HSA-73614|Reactome: R-HSA-73621 TK78_RS12165 de6740e29bdb145759e497177f49bd8d 425 Gene3D G3DSA:3.90.1170.30 318 409 2.9E-31 T 09-03-2017 IPR013102 Pyrimidine nucleoside phosphorylase, C-terminal GO:0006213|GO:0016763 Reactome: R-HSA-73614|Reactome: R-HSA-73621 TK78_RS12165 de6740e29bdb145759e497177f49bd8d 425 ProSitePatterns PS00647 Thymidine and pyrimidine-nucleoside phosphorylases signature. 110 125 - T 09-03-2017 IPR017872 Pyrimidine-nucleoside phosphorylase, conserved site GO:0006206 Reactome: R-HSA-73614|Reactome: R-HSA-73621 TK78_RS12165 de6740e29bdb145759e497177f49bd8d 425 Gene3D G3DSA:1.20.970.10 1 67 3.1E-28 T 09-03-2017 TK78_RS12165 de6740e29bdb145759e497177f49bd8d 425 Pfam PF02885 Glycosyl transferase family, helical bundle domain 6 66 4.9E-19 T 09-03-2017 IPR017459 Glycosyl transferase family 3, N-terminal domain Reactome: R-HSA-73614|Reactome: R-HSA-73621 TK78_RS12165 de6740e29bdb145759e497177f49bd8d 425 SUPERFAMILY SSF47648 1 69 1.83E-20 T 09-03-2017 IPR017459 Glycosyl transferase family 3, N-terminal domain Reactome: R-HSA-73614|Reactome: R-HSA-73621 TK78_RS12165 de6740e29bdb145759e497177f49bd8d 425 Pfam PF07831 Pyrimidine nucleoside phosphorylase C-terminal domain 335 407 1.1E-23 T 09-03-2017 IPR013102 Pyrimidine nucleoside phosphorylase, C-terminal GO:0006213|GO:0016763 Reactome: R-HSA-73614|Reactome: R-HSA-73621 TK78_RS12165 de6740e29bdb145759e497177f49bd8d 425 SUPERFAMILY SSF52418 70 316 6.54E-82 T 09-03-2017 IPR000312 Glycosyl transferase, family 3 GO:0008152|GO:0016757 Reactome: R-HSA-73614|Reactome: R-HSA-73621 TK78_RS12165 de6740e29bdb145759e497177f49bd8d 425 Gene3D G3DSA:3.40.1030.10 71 316 2.0E-109 T 09-03-2017 IPR000312 Glycosyl transferase, family 3 GO:0008152|GO:0016757 Reactome: R-HSA-73614|Reactome: R-HSA-73621 TK78_RS12165 de6740e29bdb145759e497177f49bd8d 425 SUPERFAMILY SSF54680 321 416 4.97E-26 T 09-03-2017 IPR013102 Pyrimidine nucleoside phosphorylase, C-terminal GO:0006213|GO:0016763 Reactome: R-HSA-73614|Reactome: R-HSA-73621 TK78_RS12165 de6740e29bdb145759e497177f49bd8d 425 Pfam PF00591 Glycosyl transferase family, a/b domain 77 287 1.1E-34 T 09-03-2017 IPR000312 Glycosyl transferase, family 3 GO:0008152|GO:0016757 Reactome: R-HSA-73614|Reactome: R-HSA-73621 TK78_RS32210 8afbef881b6facd20a799d061fe4548a 349 ProSitePatterns PS00211 ABC transporters family signature. 136 150 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS32210 8afbef881b6facd20a799d061fe4548a 349 SUPERFAMILY SSF52540 1 239 3.55E-75 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS32210 8afbef881b6facd20a799d061fe4548a 349 Pfam PF00005 ABC transporter 19 163 1.0E-34 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS32210 8afbef881b6facd20a799d061fe4548a 349 Gene3D G3DSA:3.40.50.300 1 237 1.4E-76 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS32210 8afbef881b6facd20a799d061fe4548a 349 SMART SM00382 27 213 2.1E-17 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS08600 802839712d606d0d274b22d99b0707f9 195 SUPERFAMILY SSF48498 77 186 1.48E-21 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS08600 802839712d606d0d274b22d99b0707f9 195 SUPERFAMILY SSF46689 4 73 2.79E-14 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS08600 802839712d606d0d274b22d99b0707f9 195 Pfam PF00440 Bacterial regulatory proteins, tetR family 9 55 3.1E-10 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS08600 802839712d606d0d274b22d99b0707f9 195 Gene3D G3DSA:1.10.357.10 4 186 2.6E-34 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS08745 a1e546d42194130d7c734d0fe75b5e39 568 Pfam PF01590 GAF domain 23 182 1.4E-12 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS08745 a1e546d42194130d7c734d0fe75b5e39 568 SUPERFAMILY SSF55874 464 542 2.45E-5 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS08745 a1e546d42194130d7c734d0fe75b5e39 568 SUPERFAMILY SSF55781 79 195 2.18E-15 T 09-03-2017 IPR029016 GAF domain-like TK78_RS08745 a1e546d42194130d7c734d0fe75b5e39 568 SMART SM00331 215 426 8.7E-42 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS08745 a1e546d42194130d7c734d0fe75b5e39 568 SMART SM00065 22 194 4.0E-7 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS08745 a1e546d42194130d7c734d0fe75b5e39 568 SUPERFAMILY SSF81606 229 379 3.4E-6 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS08745 a1e546d42194130d7c734d0fe75b5e39 568 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 243 425 4.5E-45 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS08745 a1e546d42194130d7c734d0fe75b5e39 568 Gene3D G3DSA:3.30.450.40 10 191 7.6E-35 T 09-03-2017 IPR029016 GAF domain-like TK78_RS13185 d0bb857087710a330f1e162415163a19 241 PRINTS PR00722 Chymotrypsin serine protease family (S1) signature 67 82 3.5E-9 T 09-03-2017 IPR001314 Peptidase S1A, chymotrypsin family GO:0004252|GO:0006508 TK78_RS13185 d0bb857087710a330f1e162415163a19 241 PRINTS PR00722 Chymotrypsin serine protease family (S1) signature 111 125 3.5E-9 T 09-03-2017 IPR001314 Peptidase S1A, chymotrypsin family GO:0004252|GO:0006508 TK78_RS13185 d0bb857087710a330f1e162415163a19 241 PRINTS PR00722 Chymotrypsin serine protease family (S1) signature 193 205 3.5E-9 T 09-03-2017 IPR001314 Peptidase S1A, chymotrypsin family GO:0004252|GO:0006508 TK78_RS13185 d0bb857087710a330f1e162415163a19 241 SMART SM00020 42 235 1.1E-14 T 09-03-2017 IPR001254 Serine proteases, trypsin domain GO:0004252|GO:0006508 TK78_RS13185 d0bb857087710a330f1e162415163a19 241 Pfam PF00089 Trypsin 48 235 3.4E-25 T 09-03-2017 IPR001254 Serine proteases, trypsin domain GO:0004252|GO:0006508 TK78_RS13185 d0bb857087710a330f1e162415163a19 241 Gene3D G3DSA:2.40.10.10 77 238 1.0E-25 T 09-03-2017 TK78_RS13185 d0bb857087710a330f1e162415163a19 241 Gene3D G3DSA:2.40.10.10 43 76 3.7E-11 T 09-03-2017 TK78_RS13185 d0bb857087710a330f1e162415163a19 241 SUPERFAMILY SSF50494 8 239 8.89E-37 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS07415 f96b05bef7d2358abe931a8ea781e4c0 312 Hamap MF_00185 tRNA dimethylallyltransferase [miaA]. 10 311 27.385 T 09-03-2017 IPR018022 tRNA dimethylallyltransferase GO:0008033 KEGG: 00908+2.5.1.75|MetaCyc: PWY-2781|Reactome: R-HSA-6782315|Reactome: R-HSA-6787450 TK78_RS07415 f96b05bef7d2358abe931a8ea781e4c0 312 Gene3D G3DSA:3.40.50.300 7 176 6.8E-49 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07415 f96b05bef7d2358abe931a8ea781e4c0 312 TIGRFAM TIGR00174 miaA: tRNA dimethylallyltransferase 10 289 2.9E-73 T 09-03-2017 IPR018022 tRNA dimethylallyltransferase GO:0008033 KEGG: 00908+2.5.1.75|MetaCyc: PWY-2781|Reactome: R-HSA-6782315|Reactome: R-HSA-6787450 TK78_RS07415 f96b05bef7d2358abe931a8ea781e4c0 312 SUPERFAMILY SSF52540 10 152 2.52E-14 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07415 f96b05bef7d2358abe931a8ea781e4c0 312 Pfam PF01715 IPP transferase 43 284 8.5E-72 T 09-03-2017 IPR018022 tRNA dimethylallyltransferase GO:0008033 KEGG: 00908+2.5.1.75|MetaCyc: PWY-2781|Reactome: R-HSA-6782315|Reactome: R-HSA-6787450 TK78_RS07415 f96b05bef7d2358abe931a8ea781e4c0 312 Gene3D G3DSA:1.10.287.890 201 282 1.8E-25 T 09-03-2017 TK78_RS17650 6ef516a508b9933ad03b192e9da2eefa 314 Pfam PF12804 MobA-like NTP transferase domain 6 141 1.0E-26 T 09-03-2017 IPR025877 MobA-like NTP transferase TK78_RS17650 6ef516a508b9933ad03b192e9da2eefa 314 Gene3D G3DSA:3.90.550.10 1 194 8.3E-39 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS17650 6ef516a508b9933ad03b192e9da2eefa 314 SUPERFAMILY SSF53448 5 183 1.24E-26 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS26395 dca2fd1b8136766ba410d8150bb667e4 716 Gene3D G3DSA:3.40.50.300 16 137 7.3E-6 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS26395 dca2fd1b8136766ba410d8150bb667e4 716 PRINTS PR00364 Disease resistance protein signature 34 49 5.6E-6 T 09-03-2017 TK78_RS26395 dca2fd1b8136766ba410d8150bb667e4 716 PRINTS PR00364 Disease resistance protein signature 103 117 5.6E-6 T 09-03-2017 TK78_RS26395 dca2fd1b8136766ba410d8150bb667e4 716 PRINTS PR00364 Disease resistance protein signature 201 215 5.6E-6 T 09-03-2017 TK78_RS26395 dca2fd1b8136766ba410d8150bb667e4 716 Gene3D G3DSA:1.25.40.10 464 663 4.5E-9 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS26395 dca2fd1b8136766ba410d8150bb667e4 716 SUPERFAMILY SSF52540 6 215 2.66E-22 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS26395 dca2fd1b8136766ba410d8150bb667e4 716 SUPERFAMILY SSF48452 434 565 2.66E-6 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS22905 b738c9ce9d69f3ad017f46cbe4c9daf3 257 TIGRFAM TIGR01076 sortase_fam: sortase 114 250 2.0E-12 T 09-03-2017 IPR005754 Sortase family TK78_RS22905 b738c9ce9d69f3ad017f46cbe4c9daf3 257 Gene3D G3DSA:2.40.260.10 110 256 2.1E-26 T 09-03-2017 IPR023365 Sortase domain TK78_RS22905 b738c9ce9d69f3ad017f46cbe4c9daf3 257 SUPERFAMILY SSF63817 105 254 3.79E-30 T 09-03-2017 IPR023365 Sortase domain TK78_RS22905 b738c9ce9d69f3ad017f46cbe4c9daf3 257 Pfam PF04203 Sortase family 115 251 2.2E-26 T 09-03-2017 IPR005754 Sortase family TK78_RS00275 505a14d0ea627d2390a4401142a17658 123 Pfam PF13359 DDE superfamily endonuclease 23 118 5.5E-11 T 09-03-2017 IPR027806 Harbinger transposase-derived nuclease domain TK78_RS22070 120d59ec18476ae5a10350c02cad48fb 229 Pfam PF13559 Domain of unknown function (DUF4129) 141 209 3.4E-15 T 09-03-2017 IPR025403 Domain of unknown function DUF4129 TK78_RS29210 c9d8a73426e95a2d7607383b7a501336 792 Gene3D G3DSA:3.40.50.300 696 756 8.5E-15 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29210 c9d8a73426e95a2d7607383b7a501336 792 Gene3D G3DSA:3.40.50.300 520 649 8.5E-15 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29210 c9d8a73426e95a2d7607383b7a501336 792 Pfam PF14490 Helix-hairpin-helix containing domain 216 297 1.4E-8 T 09-03-2017 IPR029493 RecD helicase-like helix-hairpin-helix domain TK78_RS29210 c9d8a73426e95a2d7607383b7a501336 792 Pfam PF13604 AAA domain 442 553 1.1E-6 T 09-03-2017 TK78_RS29210 c9d8a73426e95a2d7607383b7a501336 792 SUPERFAMILY SSF52540 517 578 2.18E-15 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29210 c9d8a73426e95a2d7607383b7a501336 792 SUPERFAMILY SSF52540 619 763 2.18E-15 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28565 9396133be0a44cfaa36797d40c1a877e 426 PIRSF PIRSF033563 10 425 3.2E-112 T 09-03-2017 IPR008323 Uncharacterised conserved protein UCP033563 TK78_RS28565 9396133be0a44cfaa36797d40c1a877e 426 Pfam PF06245 Protein of unknown function (DUF1015) 13 421 1.5E-111 T 09-03-2017 IPR008323 Uncharacterised conserved protein UCP033563 TK78_RS07580 920f0d35227f66c73c8da235c1f1d3ed 281 TIGRFAM TIGR00560 pgsA: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 34 203 8.0E-38 T 09-03-2017 IPR004570 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase GO:0008444|GO:0008654|GO:0016021 KEGG: 00564+2.7.8.5|MetaCyc: PWY-5269|MetaCyc: PWY-5668 TK78_RS07580 920f0d35227f66c73c8da235c1f1d3ed 281 ProSitePatterns PS00379 CDP-alcohol phosphatidyltransferases signature. 82 104 - T 09-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 TK78_RS07580 920f0d35227f66c73c8da235c1f1d3ed 281 Pfam PF01066 CDP-alcohol phosphatidyltransferase 34 104 9.6E-16 T 09-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 TK78_RS03610 9932e0b95606b3dbaf041083075ed667 204 Pfam PF03029 Conserved hypothetical ATP binding protein 30 194 2.3E-24 T 09-03-2017 IPR004130 GPN-loop GTPase TK78_RS03610 9932e0b95606b3dbaf041083075ed667 204 Gene3D G3DSA:3.40.50.300 23 195 4.3E-13 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03610 9932e0b95606b3dbaf041083075ed667 204 PRINTS PR00449 Transforming protein P21 ras signature 26 47 1.5E-5 T 09-03-2017 TK78_RS03610 9932e0b95606b3dbaf041083075ed667 204 PRINTS PR00449 Transforming protein P21 ras signature 84 106 1.5E-5 T 09-03-2017 TK78_RS03610 9932e0b95606b3dbaf041083075ed667 204 PRINTS PR00449 Transforming protein P21 ras signature 174 196 1.5E-5 T 09-03-2017 TK78_RS03610 9932e0b95606b3dbaf041083075ed667 204 SUPERFAMILY SSF52540 26 197 2.01E-19 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS05105 e02fce2125e96a473702421099b91658 289 SUPERFAMILY SSF103481 43 118 6.28E-5 T 09-03-2017 TK78_RS06935 1f565324aa9364d2d8daca0a70e07414 375 Hamap MF_00323 Ferrochelatase [hemH]. 9 330 30.735 T 09-03-2017 IPR001015 Ferrochelatase GO:0004325|GO:0006783 KEGG: 00860+4.99.1.1|Reactome: R-HSA-189451 TK78_RS06935 1f565324aa9364d2d8daca0a70e07414 375 SUPERFAMILY SSF53800 9 342 6.38E-82 T 09-03-2017 TK78_RS06935 1f565324aa9364d2d8daca0a70e07414 375 Gene3D G3DSA:3.40.50.1400 9 164 1.1E-39 T 09-03-2017 TK78_RS06935 1f565324aa9364d2d8daca0a70e07414 375 Gene3D G3DSA:3.40.50.1400 165 310 1.6E-46 T 09-03-2017 TK78_RS06935 1f565324aa9364d2d8daca0a70e07414 375 Pfam PF00762 Ferrochelatase 11 329 3.3E-93 T 09-03-2017 IPR001015 Ferrochelatase GO:0004325|GO:0006783 KEGG: 00860+4.99.1.1|Reactome: R-HSA-189451 TK78_RS24905 2bb9f2b30d0878f28c115139cede6de5 353 Gene3D G3DSA:3.40.50.1980 232 351 2.6E-34 T 09-03-2017 TK78_RS24905 2bb9f2b30d0878f28c115139cede6de5 353 Pfam PF01297 Zinc-uptake complex component A periplasmic 42 349 3.1E-71 T 09-03-2017 IPR006127 Periplasmic solute binding protein, ZnuA-like GO:0030001|GO:0046872 TK78_RS24905 2bb9f2b30d0878f28c115139cede6de5 353 SUPERFAMILY SSF53807 21 124 6.38E-72 T 09-03-2017 TK78_RS24905 2bb9f2b30d0878f28c115139cede6de5 353 SUPERFAMILY SSF53807 175 351 6.38E-72 T 09-03-2017 TK78_RS24905 2bb9f2b30d0878f28c115139cede6de5 353 Gene3D G3DSA:3.40.50.1980 174 231 1.3E-40 T 09-03-2017 TK78_RS24905 2bb9f2b30d0878f28c115139cede6de5 353 Gene3D G3DSA:3.40.50.1980 24 138 1.3E-40 T 09-03-2017 TK78_RS07795 c985adf728f568da6a7de6ce6e4acef1 318 SMART SM00904 187 312 7.5E-47 T 09-03-2017 IPR015865 Riboflavin kinase domain, bacterial/eukaryotic GO:0008531|GO:0009231 Reactome: R-HSA-196843 TK78_RS07795 c985adf728f568da6a7de6ce6e4acef1 318 Pfam PF01687 Riboflavin kinase 188 308 8.8E-31 T 09-03-2017 IPR015865 Riboflavin kinase domain, bacterial/eukaryotic GO:0008531|GO:0009231 Reactome: R-HSA-196843 TK78_RS07795 c985adf728f568da6a7de6ce6e4acef1 318 PIRSF PIRSF004491 1 317 5.3E-94 T 09-03-2017 IPR002606 Riboflavin kinase, bacterial GO:0003919|GO:0008531|GO:0009231 KEGG: 00740+2.7.1.26+2.7.7.2|MetaCyc: PWY-5523|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TK78_RS07795 c985adf728f568da6a7de6ce6e4acef1 318 TIGRFAM TIGR00083 ribF: riboflavin biosynthesis protein RibF 19 309 7.6E-66 T 09-03-2017 IPR002606 Riboflavin kinase, bacterial GO:0003919|GO:0008531|GO:0009231 KEGG: 00740+2.7.1.26+2.7.7.2|MetaCyc: PWY-5523|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TK78_RS07795 c985adf728f568da6a7de6ce6e4acef1 318 SUPERFAMILY SSF82114 178 312 4.8E-41 T 09-03-2017 IPR015865 Riboflavin kinase domain, bacterial/eukaryotic GO:0008531|GO:0009231 Reactome: R-HSA-196843 TK78_RS07795 c985adf728f568da6a7de6ce6e4acef1 318 Pfam PF06574 FAD synthetase 12 158 1.3E-50 T 09-03-2017 IPR015864 FAD synthetase GO:0003919|GO:0009231 KEGG: 00740+2.7.1.26+2.7.7.2|MetaCyc: PWY-5523|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TK78_RS07795 c985adf728f568da6a7de6ce6e4acef1 318 Gene3D G3DSA:2.40.30.30 184 312 1.2E-43 T 09-03-2017 IPR023465 Riboflavin kinase domain GO:0008531|GO:0009231 Reactome: R-HSA-196843 TK78_RS07795 c985adf728f568da6a7de6ce6e4acef1 318 Gene3D G3DSA:3.40.50.620 3 183 1.8E-62 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS07795 c985adf728f568da6a7de6ce6e4acef1 318 SUPERFAMILY SSF52374 16 179 9.29E-33 T 09-03-2017 TK78_RS13050 9cf68e4752a1dad633acd5af3ac5dcfc 278 TIGRFAM TIGR00500 met_pdase_I: methionine aminopeptidase, type I 3 257 1.4E-82 T 09-03-2017 IPR002467 Peptidase M24A, methionine aminopeptidase, subfamily 1 GO:0004177|GO:0006508|GO:0008235 TK78_RS13050 9cf68e4752a1dad633acd5af3ac5dcfc 278 Pfam PF00557 Metallopeptidase family M24 11 249 1.1E-41 T 09-03-2017 IPR000994 Peptidase M24, structural domain TK78_RS13050 9cf68e4752a1dad633acd5af3ac5dcfc 278 ProSitePatterns PS00680 Methionine aminopeptidase subfamily 1 signature. 173 191 - T 09-03-2017 IPR002467 Peptidase M24A, methionine aminopeptidase, subfamily 1 GO:0004177|GO:0006508|GO:0008235 TK78_RS13050 9cf68e4752a1dad633acd5af3ac5dcfc 278 SUPERFAMILY SSF55920 2 259 1.44E-72 T 09-03-2017 IPR000994 Peptidase M24, structural domain TK78_RS13050 9cf68e4752a1dad633acd5af3ac5dcfc 278 Gene3D G3DSA:3.90.230.10 3 259 1.6E-76 T 09-03-2017 IPR000994 Peptidase M24, structural domain TK78_RS13050 9cf68e4752a1dad633acd5af3ac5dcfc 278 Hamap MF_01974 Methionine aminopeptidase [map]. 2 258 37.594 T 09-03-2017 IPR002467 Peptidase M24A, methionine aminopeptidase, subfamily 1 GO:0004177|GO:0006508|GO:0008235 TK78_RS13050 9cf68e4752a1dad633acd5af3ac5dcfc 278 PRINTS PR00599 Methionine aminopeptidase-1 signature 67 80 1.4E-21 T 09-03-2017 IPR001714 Peptidase M24, methionine aminopeptidase TK78_RS13050 9cf68e4752a1dad633acd5af3ac5dcfc 278 PRINTS PR00599 Methionine aminopeptidase-1 signature 90 106 1.4E-21 T 09-03-2017 IPR001714 Peptidase M24, methionine aminopeptidase TK78_RS13050 9cf68e4752a1dad633acd5af3ac5dcfc 278 PRINTS PR00599 Methionine aminopeptidase-1 signature 167 179 1.4E-21 T 09-03-2017 IPR001714 Peptidase M24, methionine aminopeptidase TK78_RS13050 9cf68e4752a1dad633acd5af3ac5dcfc 278 PRINTS PR00599 Methionine aminopeptidase-1 signature 200 212 1.4E-21 T 09-03-2017 IPR001714 Peptidase M24, methionine aminopeptidase TK78_RS24365 baea7487c4555fc756307d24daa7cbb9 381 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 197 379 9.2E-32 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS24365 baea7487c4555fc756307d24daa7cbb9 381 SUPERFAMILY SSF81606 204 364 7.32E-5 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS24365 baea7487c4555fc756307d24daa7cbb9 381 SMART SM00331 165 379 6.9E-13 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS20945 440cd4baac589096990cde334139cfb6 412 Gene3D G3DSA:3.90.1150.10 14 71 2.8E-35 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS20945 440cd4baac589096990cde334139cfb6 412 Gene3D G3DSA:3.90.1150.10 321 411 2.8E-35 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS20945 440cd4baac589096990cde334139cfb6 412 Pfam PF00202 Aminotransferase class-III 29 411 2.0E-114 T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS20945 440cd4baac589096990cde334139cfb6 412 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 236 273 - T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS20945 440cd4baac589096990cde334139cfb6 412 Gene3D G3DSA:3.40.640.10 72 316 2.2E-84 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS20945 440cd4baac589096990cde334139cfb6 412 TIGRFAM TIGR01885 Orn_aminotrans: ornithine--oxo-acid transaminase 17 411 1.2E-144 T 09-03-2017 IPR010164 Ornithine aminotransferase GO:0008483|GO:0030170 KEGG: 00330+2.6.1.13|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344|MetaCyc: PWY-6922|Reactome: R-HSA-70614 TK78_RS20945 440cd4baac589096990cde334139cfb6 412 SUPERFAMILY SSF53383 15 411 3.75E-118 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS05085 08ec7f1c94425fef13832f4a4e2b0191 535 Pfam PF13193 AMP-binding enzyme C-terminal domain 447 523 7.4E-20 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS05085 08ec7f1c94425fef13832f4a4e2b0191 535 Gene3D G3DSA:2.30.38.10 354 429 7.2E-26 T 09-03-2017 TK78_RS05085 08ec7f1c94425fef13832f4a4e2b0191 535 Pfam PF00501 AMP-binding enzyme 25 438 1.4E-112 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS05085 08ec7f1c94425fef13832f4a4e2b0191 535 SUPERFAMILY SSF56801 18 535 6.93E-162 T 09-03-2017 TK78_RS05085 08ec7f1c94425fef13832f4a4e2b0191 535 Gene3D G3DSA:3.30.300.30 433 533 1.9E-33 T 09-03-2017 TK78_RS05085 08ec7f1c94425fef13832f4a4e2b0191 535 Gene3D G3DSA:3.40.50.980 202 347 2.2E-52 T 09-03-2017 TK78_RS05085 08ec7f1c94425fef13832f4a4e2b0191 535 Gene3D G3DSA:3.40.50.980 19 201 3.1E-40 T 09-03-2017 TK78_RS05085 08ec7f1c94425fef13832f4a4e2b0191 535 ProSitePatterns PS00455 Putative AMP-binding domain signature. 187 198 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS22345 c6961ff8823c55773e4acd1b18cacec0 790 Gene3D G3DSA:3.40.50.300 633 774 1.1E-20 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22345 c6961ff8823c55773e4acd1b18cacec0 790 SUPERFAMILY SSF52540 214 292 4.67E-48 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22345 c6961ff8823c55773e4acd1b18cacec0 790 SUPERFAMILY SSF52540 389 454 4.67E-48 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22345 c6961ff8823c55773e4acd1b18cacec0 790 SUPERFAMILY SSF52540 553 779 4.67E-48 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22345 c6961ff8823c55773e4acd1b18cacec0 790 Pfam PF13538 UvrD-like helicase C-terminal domain 730 772 3.4E-8 T 09-03-2017 IPR027785 UvrD-like helicase C-terminal domain TK78_RS22345 c6961ff8823c55773e4acd1b18cacec0 790 Pfam PF00580 UvrD/REP helicase N-terminal domain 560 607 2.3E-6 T 09-03-2017 IPR014016 UvrD-like Helicase, ATP-binding domain GO:0005524 TK78_RS22345 c6961ff8823c55773e4acd1b18cacec0 790 Pfam PF13245 Part of AAA domain 228 284 2.0E-13 T 09-03-2017 TK78_RS22345 c6961ff8823c55773e4acd1b18cacec0 790 Gene3D G3DSA:3.40.50.300 446 609 1.8E-35 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22345 c6961ff8823c55773e4acd1b18cacec0 790 Gene3D G3DSA:3.40.50.300 220 288 1.8E-35 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01295 ad8b26b23b4473dbcf77b3acae75474a 299 Gene3D G3DSA:2.40.30.10 2 123 4.6E-30 T 09-03-2017 TK78_RS01295 ad8b26b23b4473dbcf77b3acae75474a 299 Pfam PF08021 Siderophore-interacting FAD-binding domain 8 123 8.8E-34 T 09-03-2017 IPR013113 FAD-binding 9, siderophore-interacting TK78_RS01295 ad8b26b23b4473dbcf77b3acae75474a 299 Pfam PF04954 Siderophore-interacting protein 132 249 2.7E-29 T 09-03-2017 IPR007037 Siderophore-interacting protein TK78_RS01295 ad8b26b23b4473dbcf77b3acae75474a 299 Gene3D G3DSA:3.40.50.80 126 255 8.2E-36 T 09-03-2017 TK78_RS01295 ad8b26b23b4473dbcf77b3acae75474a 299 SUPERFAMILY SSF63380 4 125 4.84E-12 T 09-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 TK78_RS26255 d67543402f1b90e2929ae1f9dedd7bbc 530 Gene3D G3DSA:2.60.40.420 410 528 1.8E-38 T 09-03-2017 IPR008972 Cupredoxin TK78_RS26255 d67543402f1b90e2929ae1f9dedd7bbc 530 SUPERFAMILY SSF49503 408 525 5.13E-31 T 09-03-2017 IPR008972 Cupredoxin TK78_RS26255 d67543402f1b90e2929ae1f9dedd7bbc 530 SUPERFAMILY SSF49503 192 387 6.77E-31 T 09-03-2017 IPR008972 Cupredoxin TK78_RS26255 d67543402f1b90e2929ae1f9dedd7bbc 530 ProSitePatterns PS00079 Multicopper oxidases signature 1. 506 526 - T 09-03-2017 IPR033138 Multicopper oxidases, conserved site TK78_RS26255 d67543402f1b90e2929ae1f9dedd7bbc 530 Pfam PF07731 Multicopper oxidase 419 526 4.1E-25 T 09-03-2017 IPR011706 Multicopper oxidase, type 2 GO:0005507|GO:0016491|GO:0055114 TK78_RS26255 d67543402f1b90e2929ae1f9dedd7bbc 530 Pfam PF07732 Multicopper oxidase 79 190 2.3E-33 T 09-03-2017 IPR011707 Multicopper oxidase, type 3 GO:0005507 TK78_RS26255 d67543402f1b90e2929ae1f9dedd7bbc 530 SUPERFAMILY SSF49503 64 191 1.22E-34 T 09-03-2017 IPR008972 Cupredoxin TK78_RS26255 d67543402f1b90e2929ae1f9dedd7bbc 530 Gene3D G3DSA:2.60.40.420 65 192 2.7E-32 T 09-03-2017 IPR008972 Cupredoxin TK78_RS26255 d67543402f1b90e2929ae1f9dedd7bbc 530 Pfam PF00394 Multicopper oxidase 277 379 3.1E-20 T 09-03-2017 IPR001117 Multicopper oxidase, type 1 GO:0016491|GO:0055114 TK78_RS26255 d67543402f1b90e2929ae1f9dedd7bbc 530 ProSitePatterns PS00080 Multicopper oxidases signature 2. 511 522 - T 09-03-2017 IPR002355 Multicopper oxidase, copper-binding site GO:0005507 TK78_RS26255 d67543402f1b90e2929ae1f9dedd7bbc 530 Gene3D G3DSA:2.60.40.420 195 391 1.9E-47 T 09-03-2017 IPR008972 Cupredoxin TK78_RS17505 6ef111335efea6e1c1db78028ab3a443 246 Gene3D G3DSA:2.40.260.10 85 232 7.5E-25 T 09-03-2017 IPR023365 Sortase domain TK78_RS17505 6ef111335efea6e1c1db78028ab3a443 246 TIGRFAM TIGR01076 sortase_fam: sortase 91 227 8.8E-13 T 09-03-2017 IPR005754 Sortase family TK78_RS17505 6ef111335efea6e1c1db78028ab3a443 246 SUPERFAMILY SSF63817 83 232 2.88E-29 T 09-03-2017 IPR023365 Sortase domain TK78_RS17505 6ef111335efea6e1c1db78028ab3a443 246 Pfam PF04203 Sortase family 93 228 9.8E-25 T 09-03-2017 IPR005754 Sortase family TK78_RS23605 06acba4ffe5f38d5cf90f5637b82d6d1 207 Pfam PF08044 Domain of unknown function (DUF1707) 18 70 1.5E-18 T 09-03-2017 IPR012551 Protein of unknown function DUF1707 TK78_RS26495 8172a648bc1de5156279018a30365ff1 121 Gene3D G3DSA:3.40.30.10 1 118 3.8E-37 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS26495 8172a648bc1de5156279018a30365ff1 121 SUPERFAMILY SSF52833 2 118 1.2E-26 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS26495 8172a648bc1de5156279018a30365ff1 121 Pfam PF03960 ArsC family 54 115 5.2E-10 T 09-03-2017 IPR006660 Arsenate reductase-like TK78_RS21890 c5a9bf00996c981e087f8830ae84e725 65 Pfam PF04149 Domain of unknown function (DUF397) 15 60 1.4E-15 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS13910 b07ae214be910b2bf37ee7bb6ef726d7 115 Gene3D G3DSA:3.10.180.10 1 114 2.0E-31 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS13910 b07ae214be910b2bf37ee7bb6ef726d7 115 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 65 107 8.4E-6 T 09-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain TK78_RS13910 b07ae214be910b2bf37ee7bb6ef726d7 115 SUPERFAMILY SSF54593 6 114 2.42E-23 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS05525 4f57be941e94094193799c8453fb992c 212 Gene3D G3DSA:3.40.30.10 8 171 2.1E-16 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS05525 4f57be941e94094193799c8453fb992c 212 Pfam PF01323 DSBA-like thioredoxin domain 15 170 7.6E-12 T 09-03-2017 IPR001853 DSBA-like thioredoxin domain GO:0015035 Reactome: R-HSA-156590 TK78_RS05525 4f57be941e94094193799c8453fb992c 212 SUPERFAMILY SSF52833 14 172 3.52E-20 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS30895 9061bd6d8648541b9bdad19c4e82a465 116 SUPERFAMILY SSF55874 5 101 8.38E-20 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS30895 9061bd6d8648541b9bdad19c4e82a465 116 PRINTS PR00344 Bacterial sensor protein C-terminal signature 64 82 7.6E-9 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS30895 9061bd6d8648541b9bdad19c4e82a465 116 PRINTS PR00344 Bacterial sensor protein C-terminal signature 88 101 7.6E-9 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS30895 9061bd6d8648541b9bdad19c4e82a465 116 PRINTS PR00344 Bacterial sensor protein C-terminal signature 49 63 7.6E-9 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS30895 9061bd6d8648541b9bdad19c4e82a465 116 Gene3D G3DSA:3.30.565.10 17 102 9.7E-13 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS30895 9061bd6d8648541b9bdad19c4e82a465 116 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 15 101 2.4E-9 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS30895 9061bd6d8648541b9bdad19c4e82a465 116 SMART SM00387 13 104 5.1E-12 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS08010 85d03646322d3c97597723db9e65b987 245 Gene3D G3DSA:3.40.50.300 9 227 7.4E-55 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08010 85d03646322d3c97597723db9e65b987 245 SUPERFAMILY SSF52540 9 228 4.36E-50 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08010 85d03646322d3c97597723db9e65b987 245 SMART SM00382 34 222 9.2E-12 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS08010 85d03646322d3c97597723db9e65b987 245 Pfam PF00005 ABC transporter 27 174 6.2E-26 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS26190 6ba379545345dd4fea4c99838e2ecd25 237 TIGRFAM TIGR01915 npdG: NADPH-dependent F420 reductase 27 233 7.2E-76 T 09-03-2017 IPR010185 NADPH-dependent F420 reductase GO:0006740|GO:0016651|GO:0050661|GO:0055114|GO:0070967 TK78_RS26190 6ba379545345dd4fea4c99838e2ecd25 237 SUPERFAMILY SSF51735 29 231 7.71E-41 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS26190 6ba379545345dd4fea4c99838e2ecd25 237 Pfam PF03807 NADP oxidoreductase coenzyme F420-dependent 29 120 5.4E-22 T 09-03-2017 IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal TK78_RS26190 6ba379545345dd4fea4c99838e2ecd25 237 Gene3D G3DSA:3.40.50.720 28 230 9.3E-61 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS27930 e0c094278e456245361061db05fe7cde 510 PRINTS PR00079 Glucose-6-phosphate dehydrogenase signature 350 376 4.8E-48 T 09-03-2017 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 TK78_RS27930 e0c094278e456245361061db05fe7cde 510 PRINTS PR00079 Glucose-6-phosphate dehydrogenase signature 167 180 4.8E-48 T 09-03-2017 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 TK78_RS27930 e0c094278e456245361061db05fe7cde 510 PRINTS PR00079 Glucose-6-phosphate dehydrogenase signature 191 219 4.8E-48 T 09-03-2017 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 TK78_RS27930 e0c094278e456245361061db05fe7cde 510 PRINTS PR00079 Glucose-6-phosphate dehydrogenase signature 243 260 4.8E-48 T 09-03-2017 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 TK78_RS27930 e0c094278e456245361061db05fe7cde 510 PRINTS PR00079 Glucose-6-phosphate dehydrogenase signature 261 277 4.8E-48 T 09-03-2017 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 TK78_RS27930 e0c094278e456245361061db05fe7cde 510 SUPERFAMILY SSF51735 15 214 1.14E-62 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS27930 e0c094278e456245361061db05fe7cde 510 Pfam PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 28 211 5.3E-63 T 09-03-2017 IPR022674 Glucose-6-phosphate dehydrogenase, NAD-binding GO:0004345|GO:0006006|GO:0050661|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 TK78_RS27930 e0c094278e456245361061db05fe7cde 510 SUPERFAMILY SSF55347 201 508 1.14E-111 T 09-03-2017 TK78_RS27930 e0c094278e456245361061db05fe7cde 510 Gene3D G3DSA:3.40.50.720 24 210 8.0E-70 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS27930 e0c094278e456245361061db05fe7cde 510 TIGRFAM TIGR00871 zwf: glucose-6-phosphate dehydrogenase 26 509 2.1E-198 T 09-03-2017 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 TK78_RS27930 e0c094278e456245361061db05fe7cde 510 ProSitePatterns PS00069 Glucose-6-phosphate dehydrogenase active site. 201 207 - T 09-03-2017 IPR019796 Glucose-6-phosphate dehydrogenase, active site GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 TK78_RS27930 e0c094278e456245361061db05fe7cde 510 Gene3D G3DSA:3.30.360.10 211 508 9.2E-119 T 09-03-2017 TK78_RS27930 e0c094278e456245361061db05fe7cde 510 PIRSF PIRSF000110 11 510 7.2E-178 T 09-03-2017 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 TK78_RS27930 e0c094278e456245361061db05fe7cde 510 Hamap MF_00966 Glucose-6-phosphate 1-dehydrogenase [zwf]. 24 509 86.043 T 09-03-2017 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 TK78_RS27930 e0c094278e456245361061db05fe7cde 510 Pfam PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 213 508 1.6E-111 T 09-03-2017 IPR022675 Glucose-6-phosphate dehydrogenase, C-terminal GO:0004345|GO:0006006|GO:0050661|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 TK78_RS20935 f4d0bd8ed09e338a92a813f407e649b8 176 Pfam PF01037 Lrp/AsnC ligand binding domain 74 144 9.2E-14 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS20935 f4d0bd8ed09e338a92a813f407e649b8 176 Gene3D G3DSA:3.30.70.920 62 140 1.8E-16 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS20935 f4d0bd8ed09e338a92a813f407e649b8 176 SUPERFAMILY SSF46785 8 68 6.98E-15 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS20935 f4d0bd8ed09e338a92a813f407e649b8 176 Pfam PF13404 AsnC-type helix-turn-helix domain 9 49 1.4E-15 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS20935 f4d0bd8ed09e338a92a813f407e649b8 176 Gene3D G3DSA:1.10.10.10 9 59 5.3E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS20935 f4d0bd8ed09e338a92a813f407e649b8 176 SMART SM00344 8 115 1.9E-29 T 09-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 TK78_RS20935 f4d0bd8ed09e338a92a813f407e649b8 176 ProSitePatterns PS00519 AsnC-type HTH domain signature. 26 52 - T 09-03-2017 IPR019885 Transcription regulator HTH, AsnC-type, conserved site TK78_RS20935 f4d0bd8ed09e338a92a813f407e649b8 176 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 24 35 9.1E-12 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS20935 f4d0bd8ed09e338a92a813f407e649b8 176 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 35 54 9.1E-12 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS20935 f4d0bd8ed09e338a92a813f407e649b8 176 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 8 24 9.1E-12 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS20935 f4d0bd8ed09e338a92a813f407e649b8 176 SUPERFAMILY SSF54909 69 147 3.89E-13 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS08830 8e9665ca42656908ee6ba5fe6c8b976b 700 Pfam PF04185 Phosphoesterase family 50 453 3.8E-94 T 09-03-2017 IPR007312 Phosphoesterase GO:0016788 TK78_RS08830 8e9665ca42656908ee6ba5fe6c8b976b 700 TIGRFAM TIGR03396 PC_PLC: phospholipase C, phosphocholine-specific 6 699 4.4E-209 T 09-03-2017 IPR017767 Bacterial phospholipase C, phosphocholine-specific GO:0034480 KEGG: 00562+3.1.4.3|KEGG: 00564+3.1.4.3|KEGG: 00565+3.1.4.3 TK78_RS08830 8e9665ca42656908ee6ba5fe6c8b976b 700 Pfam PF05506 Domain of unknown function (DUF756) 516 597 5.2E-17 T 09-03-2017 IPR008475 Bacterial phospholipase C, C-terminal domain GO:0004629|GO:0016042 KEGG: 00562+3.1.4.3|KEGG: 00564+3.1.4.3|KEGG: 00565+3.1.4.3 TK78_RS08830 8e9665ca42656908ee6ba5fe6c8b976b 700 Pfam PF05506 Domain of unknown function (DUF756) 609 690 6.4E-16 T 09-03-2017 IPR008475 Bacterial phospholipase C, C-terminal domain GO:0004629|GO:0016042 KEGG: 00562+3.1.4.3|KEGG: 00564+3.1.4.3|KEGG: 00565+3.1.4.3 TK78_RS31005 c56e7ebd8696301faa24696444568826 388 SUPERFAMILY SSF53383 11 385 1.67E-98 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS31005 c56e7ebd8696301faa24696444568826 388 Gene3D G3DSA:3.90.1150.10 251 387 2.3E-56 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS31005 c56e7ebd8696301faa24696444568826 388 Gene3D G3DSA:3.40.640.10 14 250 1.0E-67 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS31005 c56e7ebd8696301faa24696444568826 388 Pfam PF01041 DegT/DnrJ/EryC1/StrS aminotransferase family 20 380 2.2E-113 T 09-03-2017 IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase TK78_RS31005 c56e7ebd8696301faa24696444568826 388 PIRSF PIRSF000390 5 386 5.2E-109 T 09-03-2017 IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase TK78_RS24225 7bb2d5a770daf87adb14ca750c10536d 1100 ProSitePatterns PS00138 Serine proteases, subtilase family, serine active site. 580 590 - T 09-03-2017 IPR023828 Peptidase S8, subtilisin, Ser-active site TK78_RS24225 7bb2d5a770daf87adb14ca750c10536d 1100 Pfam PF00082 Subtilase family 202 633 5.8E-56 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS24225 7bb2d5a770daf87adb14ca750c10536d 1100 PRINTS PR00723 Subtilisin serine protease family (S8) signature 202 221 1.1E-16 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS24225 7bb2d5a770daf87adb14ca750c10536d 1100 PRINTS PR00723 Subtilisin serine protease family (S8) signature 382 395 1.1E-16 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS24225 7bb2d5a770daf87adb14ca750c10536d 1100 PRINTS PR00723 Subtilisin serine protease family (S8) signature 579 595 1.1E-16 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS24225 7bb2d5a770daf87adb14ca750c10536d 1100 Gene3D G3DSA:3.40.50.200 386 641 9.3E-69 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS24225 7bb2d5a770daf87adb14ca750c10536d 1100 Gene3D G3DSA:3.40.50.200 198 246 9.3E-69 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS24225 7bb2d5a770daf87adb14ca750c10536d 1100 Gene3D G3DSA:2.60.120.380 968 1026 9.5E-4 T 09-03-2017 TK78_RS24225 7bb2d5a770daf87adb14ca750c10536d 1100 ProSitePatterns PS00136 Serine proteases, subtilase family, aspartic acid active site. 207 218 - T 09-03-2017 IPR023827 Peptidase S8, subtilisin, Asp-active site TK78_RS24225 7bb2d5a770daf87adb14ca750c10536d 1100 SUPERFAMILY SSF52743 197 222 7.07E-55 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS24225 7bb2d5a770daf87adb14ca750c10536d 1100 SUPERFAMILY SSF52743 385 642 7.07E-55 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS31460 48cd9c7c45212d3289ffcab8cc128f3e 530 Pfam PF16655 PhoD-like phosphatase, N-terminal domain 53 143 3.5E-13 T 09-03-2017 IPR032093 Phospholipase D, N-terminal TK78_RS31460 48cd9c7c45212d3289ffcab8cc128f3e 530 SUPERFAMILY SSF56300 151 523 6.56E-38 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS31460 48cd9c7c45212d3289ffcab8cc128f3e 530 Pfam PF09423 PhoD-like phosphatase 160 509 1.6E-77 T 09-03-2017 IPR018946 Alkaline phosphatase D-related TK78_RS31460 48cd9c7c45212d3289ffcab8cc128f3e 530 Gene3D G3DSA:3.60.21.10 148 527 2.0E-40 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS27820 e61d54769eb8ffeb7ec24d0644f78432 229 Gene3D G3DSA:1.20.120.450 10 136 5.9E-5 T 09-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase TK78_RS27820 e61d54769eb8ffeb7ec24d0644f78432 229 SUPERFAMILY SSF109854 1 146 6.18E-39 T 09-03-2017 TK78_RS27820 e61d54769eb8ffeb7ec24d0644f78432 229 Pfam PF07398 MDMPI C-terminal domain 147 225 8.5E-8 T 09-03-2017 IPR010872 MDMPI C-terminal TK78_RS27820 e61d54769eb8ffeb7ec24d0644f78432 229 SUPERFAMILY SSF55718 148 228 1.06E-15 T 09-03-2017 IPR003033 SCP2 sterol-binding domain TK78_RS27820 e61d54769eb8ffeb7ec24d0644f78432 229 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 11 140 4.4E-22 T 09-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 TK78_RS27820 e61d54769eb8ffeb7ec24d0644f78432 229 TIGRFAM TIGR03083 TIGR03083: uncharacterized Actinobacterial protein TIGR03083 10 210 9.5E-39 T 09-03-2017 IPR017517 Conserved hypothetical protein CHP03083, actinobacterial-type TK78_RS17360 d2c1ab58d48e8d096aa72370a732bd13 45 Pfam PF00468 Ribosomal protein L34 3 45 6.6E-20 T 09-03-2017 IPR000271 Ribosomal protein L34 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS17360 d2c1ab58d48e8d096aa72370a732bd13 45 Hamap MF_00391 50S ribosomal protein L34 [rpmH]. 2 45 15.336 T 09-03-2017 IPR000271 Ribosomal protein L34 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS17360 d2c1ab58d48e8d096aa72370a732bd13 45 TIGRFAM TIGR01030 rpmH_bact: ribosomal protein bL34 3 45 1.4E-19 T 09-03-2017 IPR000271 Ribosomal protein L34 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS17360 d2c1ab58d48e8d096aa72370a732bd13 45 ProDom PD003101 RIBOSOMAL L34 RIBONUCLEOPROTEIN 50S CHLOROPLAST PLASTID L34 MITOCHONDRIAL PEPTIDE SEQUENCING 3 40 3.0E-13 T 09-03-2017 IPR000271 Ribosomal protein L34 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS17360 d2c1ab58d48e8d096aa72370a732bd13 45 ProSitePatterns PS00784 Ribosomal protein L34 signature. 3 22 - T 09-03-2017 IPR020939 Ribosomal protein L34, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS28345 609c0b9d2263cd79a4372974eb8f6535 343 Pfam PF00533 BRCA1 C Terminus (BRCT) domain 245 314 6.0E-6 T 09-03-2017 IPR001357 BRCT domain TK78_RS28345 609c0b9d2263cd79a4372974eb8f6535 343 SUPERFAMILY SSF53098 16 180 1.06E-40 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS28345 609c0b9d2263cd79a4372974eb8f6535 343 Pfam PF00929 Exonuclease 23 175 2.2E-23 T 09-03-2017 IPR013520 Exonuclease, RNase T/DNA polymerase III TK78_RS28345 609c0b9d2263cd79a4372974eb8f6535 343 SUPERFAMILY SSF52113 240 316 4.25E-11 T 09-03-2017 IPR001357 BRCT domain TK78_RS28345 609c0b9d2263cd79a4372974eb8f6535 343 SMART SM00479 20 184 1.2E-34 T 09-03-2017 IPR013520 Exonuclease, RNase T/DNA polymerase III TK78_RS28345 609c0b9d2263cd79a4372974eb8f6535 343 Gene3D G3DSA:3.40.50.10190 241 318 6.8E-12 T 09-03-2017 IPR001357 BRCT domain TK78_RS28345 609c0b9d2263cd79a4372974eb8f6535 343 TIGRFAM TIGR00573 dnaq: exonuclease, DNA polymerase III, epsilon subunit family 21 177 5.0E-23 T 09-03-2017 IPR006054 DNA polymerase III, epsilon subunit GO:0003677|GO:0003887|GO:0006260 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS28345 609c0b9d2263cd79a4372974eb8f6535 343 SMART SM00292 241 319 0.0019 T 09-03-2017 IPR001357 BRCT domain TK78_RS28345 609c0b9d2263cd79a4372974eb8f6535 343 Gene3D G3DSA:3.30.420.10 18 178 3.4E-44 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS16555 5c62e942f425e953aa2fcc9bc2809e17 280 SUPERFAMILY SSF47413 9 65 1.38E-10 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS16555 5c62e942f425e953aa2fcc9bc2809e17 280 SMART SM00530 15 70 4.5E-6 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS16555 5c62e942f425e953aa2fcc9bc2809e17 280 Pfam PF13560 Helix-turn-helix domain 11 68 2.2E-12 T 09-03-2017 TK78_RS16555 5c62e942f425e953aa2fcc9bc2809e17 280 Gene3D G3DSA:1.10.260.40 3 66 4.3E-16 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS22305 e0c670fa59e04477b377d759ad26dbff 738 Pfam PF13641 Glycosyltransferase like family 2 367 585 5.0E-44 T 09-03-2017 TK78_RS22305 e0c670fa59e04477b377d759ad26dbff 738 Pfam PF01522 Polysaccharide deacetylase 95 203 2.0E-30 T 09-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 TK78_RS22305 e0c670fa59e04477b377d759ad26dbff 738 SUPERFAMILY SSF88713 94 294 1.71E-56 T 09-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 TK78_RS22305 e0c670fa59e04477b377d759ad26dbff 738 SUPERFAMILY SSF53448 367 617 1.06E-63 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS22305 e0c670fa59e04477b377d759ad26dbff 738 Gene3D G3DSA:3.20.20.370 93 296 3.3E-58 T 09-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 TK78_RS22305 e0c670fa59e04477b377d759ad26dbff 738 Gene3D G3DSA:3.90.550.10 367 601 1.3E-53 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS09715 3b50c9a9067a25bc0bb62c301de2e6bb 428 Hamap MF_00051 Serine hydroxymethyltransferase [glyA]. 27 427 43.97 T 09-03-2017 IPR001085 Serine hydroxymethyltransferase GO:0016740 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 TK78_RS09715 3b50c9a9067a25bc0bb62c301de2e6bb 428 SUPERFAMILY SSF53383 27 427 1.77E-141 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS09715 3b50c9a9067a25bc0bb62c301de2e6bb 428 Gene3D G3DSA:3.40.640.10 57 302 2.9E-94 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS09715 3b50c9a9067a25bc0bb62c301de2e6bb 428 Pfam PF00464 Serine hydroxymethyltransferase 30 397 1.3E-126 T 09-03-2017 IPR001085 Serine hydroxymethyltransferase GO:0016740 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 TK78_RS09715 3b50c9a9067a25bc0bb62c301de2e6bb 428 Gene3D G3DSA:3.90.1150.10 303 426 1.7E-28 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS09715 3b50c9a9067a25bc0bb62c301de2e6bb 428 PIRSF PIRSF000412 11 423 2.8E-139 T 09-03-2017 IPR001085 Serine hydroxymethyltransferase GO:0016740 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 TK78_RS00270 5a1932ac72166a9a67c7298ad9d6e921 241 SUPERFAMILY SSF52218 18 194 4.4E-27 T 09-03-2017 IPR029039 Flavoprotein-like domain TK78_RS00270 5a1932ac72166a9a67c7298ad9d6e921 241 Gene3D G3DSA:3.40.50.360 28 171 2.4E-11 T 09-03-2017 IPR029039 Flavoprotein-like domain TK78_RS00270 5a1932ac72166a9a67c7298ad9d6e921 241 Pfam PF03358 NADPH-dependent FMN reductase 28 167 4.3E-8 T 09-03-2017 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 TK78_RS21910 469d587af27aebc2070dae0581dfd7ee 462 TIGRFAM TIGR00350 lytR_cpsA_psr: cell envelope-related function transcriptional attenuator common domain 79 233 3.5E-47 T 09-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain TK78_RS21910 469d587af27aebc2070dae0581dfd7ee 462 Pfam PF13399 LytR cell envelope-related transcriptional attenuator 349 435 1.5E-13 T 09-03-2017 IPR027381 Putative LytR/CpsA/Psr regulator, C-terminal domain TK78_RS21910 469d587af27aebc2070dae0581dfd7ee 462 Pfam PF03816 Cell envelope-related transcriptional attenuator domain 79 233 1.3E-48 T 09-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain TK78_RS21740 20ae1261f2a2d60b7e9163ca132e47f2 390 TIGRFAM TIGR01224 hutI: imidazolonepropionase 29 387 1.1E-108 T 09-03-2017 IPR005920 Imidazolonepropionase GO:0005737|GO:0016812|GO:0019556 KEGG: 00340+3.5.2.7|MetaCyc: PWY-5028|MetaCyc: PWY-5030|Reactome: R-HSA-70921 TK78_RS21740 20ae1261f2a2d60b7e9163ca132e47f2 390 Gene3D G3DSA:3.20.20.140 77 366 1.5E-45 T 09-03-2017 TK78_RS21740 20ae1261f2a2d60b7e9163ca132e47f2 390 Hamap MF_00372 Imidazolonepropionase [hutI]. 3 389 42.755 T 09-03-2017 IPR005920 Imidazolonepropionase GO:0005737|GO:0016812|GO:0019556 KEGG: 00340+3.5.2.7|MetaCyc: PWY-5028|MetaCyc: PWY-5030|Reactome: R-HSA-70921 TK78_RS21740 20ae1261f2a2d60b7e9163ca132e47f2 390 Pfam PF01979 Amidohydrolase family 249 366 8.3E-18 T 09-03-2017 IPR006680 Amidohydrolase-related GO:0016787 TK78_RS21740 20ae1261f2a2d60b7e9163ca132e47f2 390 SUPERFAMILY SSF51556 65 348 9.21E-69 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS21740 20ae1261f2a2d60b7e9163ca132e47f2 390 Gene3D G3DSA:2.30.40.10 22 76 5.9E-12 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS21740 20ae1261f2a2d60b7e9163ca132e47f2 390 SUPERFAMILY SSF51338 25 66 1.85E-15 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS21740 20ae1261f2a2d60b7e9163ca132e47f2 390 SUPERFAMILY SSF51338 349 389 1.85E-15 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS14010 fe83e7cbf96031bdefd68943a6600c12 124 Pfam PF13466 STAS domain 16 80 1.4E-12 T 09-03-2017 IPR002645 STAS domain TK78_RS14010 fe83e7cbf96031bdefd68943a6600c12 124 Gene3D G3DSA:3.30.750.24 3 116 6.0E-34 T 09-03-2017 IPR002645 STAS domain TK78_RS14010 fe83e7cbf96031bdefd68943a6600c12 124 SUPERFAMILY SSF52091 3 112 5.69E-20 T 09-03-2017 IPR002645 STAS domain TK78_RS14010 fe83e7cbf96031bdefd68943a6600c12 124 TIGRFAM TIGR00377 ant_ant_sig: anti-anti-sigma factor 2 109 9.6E-18 T 09-03-2017 IPR003658 Anti-sigma factor antagonist GO:0006355|GO:0045152 TK78_RS30705 715cb76567a32f0b441a90fdd64ef46f 787 SUPERFAMILY SSF51445 276 626 4.92E-80 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS30705 715cb76567a32f0b441a90fdd64ef46f 787 SUPERFAMILY SSF51011 628 707 5.04E-19 T 09-03-2017 TK78_RS30705 715cb76567a32f0b441a90fdd64ef46f 787 Pfam PF01055 Glycosyl hydrolases family 31 268 712 7.3E-121 T 09-03-2017 IPR000322 Glycoside hydrolase family 31 GO:0004553|GO:0005975 TK78_RS30705 715cb76567a32f0b441a90fdd64ef46f 787 SUPERFAMILY SSF74650 90 271 7.85E-15 T 09-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 TK78_RS30705 715cb76567a32f0b441a90fdd64ef46f 787 ProSitePatterns PS00129 Glycosyl hydrolases family 31 active site. 439 446 - T 09-03-2017 IPR030458 Glycosyl hydrolases family 31, active site TK78_RS30705 715cb76567a32f0b441a90fdd64ef46f 787 Pfam PF13802 Galactose mutarotase-like 170 235 2.4E-9 T 09-03-2017 IPR025887 Glycoside hydrolase family 31, N-terminal domain TK78_RS19900 0cdf73ad992b920881c5548afb45342e 105 Pfam PF08239 Bacterial SH3 domain 35 81 4.7E-7 T 09-03-2017 IPR003646 SH3-like domain, bacterial-type TK78_RS06035 de382e560d96339d50bac239e5e48ec8 206 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 4 196 2.3E-47 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS06035 de382e560d96339d50bac239e5e48ec8 206 Gene3D G3DSA:3.40.50.1240 3 196 5.5E-45 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS06035 de382e560d96339d50bac239e5e48ec8 206 SMART SM00855 3 158 9.1E-21 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS06035 de382e560d96339d50bac239e5e48ec8 206 SUPERFAMILY SSF53254 1 197 1.63E-46 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS23770 23fc027c950dfbb516a5e45f80741442 976 Pfam PF00196 Bacterial regulatory proteins, luxR family 915 966 5.3E-8 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS23770 23fc027c950dfbb516a5e45f80741442 976 Gene3D G3DSA:1.10.10.10 912 970 4.7E-15 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS23770 23fc027c950dfbb516a5e45f80741442 976 SMART SM00421 911 968 6.6E-8 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS23770 23fc027c950dfbb516a5e45f80741442 976 Pfam PF13191 AAA ATPase domain 9 175 1.2E-19 T 09-03-2017 TK78_RS23770 23fc027c950dfbb516a5e45f80741442 976 SUPERFAMILY SSF52540 119 245 2.85E-11 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23770 23fc027c950dfbb516a5e45f80741442 976 SUPERFAMILY SSF52540 7 71 2.85E-11 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23770 23fc027c950dfbb516a5e45f80741442 976 Gene3D G3DSA:3.40.50.300 119 180 8.3E-6 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23770 23fc027c950dfbb516a5e45f80741442 976 Gene3D G3DSA:3.40.50.300 8 80 8.3E-6 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23770 23fc027c950dfbb516a5e45f80741442 976 SUPERFAMILY SSF46894 907 970 2.11E-13 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS13660 73c1f9682f6214a2e60370a23c27903e 184 Hamap MF_01356 NAD(P)H-quinone oxidoreductase subunit K, chloroplastic [ndhK]. 1 151 42.375 T 09-03-2017 IPR006138 NADH-ubiquinone oxidoreductase, 20 Kd subunit GO:0008137|GO:0048038|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13660 73c1f9682f6214a2e60370a23c27903e 184 SUPERFAMILY SSF56770 9 154 8.11E-66 T 09-03-2017 TK78_RS13660 73c1f9682f6214a2e60370a23c27903e 184 ProSitePatterns PS01150 Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. 118 134 - T 09-03-2017 IPR006138 NADH-ubiquinone oxidoreductase, 20 Kd subunit GO:0008137|GO:0048038|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13660 73c1f9682f6214a2e60370a23c27903e 184 Pfam PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 37 146 1.3E-24 T 09-03-2017 IPR006137 NADH:ubiquinone oxidoreductase-like, 20kDa subunit GO:0051536|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13660 73c1f9682f6214a2e60370a23c27903e 184 Gene3D G3DSA:3.40.50.700 25 149 2.3E-33 T 09-03-2017 IPR006137 NADH:ubiquinone oxidoreductase-like, 20kDa subunit GO:0051536|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13660 73c1f9682f6214a2e60370a23c27903e 184 TIGRFAM TIGR01957 nuoB_fam: NADH-quinone oxidoreductase, B subunit 11 151 1.3E-69 T 09-03-2017 IPR006138 NADH-ubiquinone oxidoreductase, 20 Kd subunit GO:0008137|GO:0048038|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS28945 96a796cc16092c410d1f5deeb531bb02 364 SMART SM00382 178 316 3.2E-5 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS28945 96a796cc16092c410d1f5deeb531bb02 364 Gene3D G3DSA:3.40.50.300 180 306 3.8E-14 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28945 96a796cc16092c410d1f5deeb531bb02 364 SUPERFAMILY SSF52540 176 318 1.4E-18 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28945 96a796cc16092c410d1f5deeb531bb02 364 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 182 312 2.7E-11 T 09-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 TK78_RS32740 12dadc7f0f3e68d6dbbb0fe611a8f56f 277 Gene3D G3DSA:3.40.50.1820 7 268 6.4E-51 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS32740 12dadc7f0f3e68d6dbbb0fe611a8f56f 277 Pfam PF00561 alpha/beta hydrolase fold 26 131 7.8E-16 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS32740 12dadc7f0f3e68d6dbbb0fe611a8f56f 277 PRINTS PR00412 Epoxide hydrolase signature 31 49 7.0E-5 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS32740 12dadc7f0f3e68d6dbbb0fe611a8f56f 277 PRINTS PR00412 Epoxide hydrolase signature 247 269 7.0E-5 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS32740 12dadc7f0f3e68d6dbbb0fe611a8f56f 277 PRINTS PR00412 Epoxide hydrolase signature 214 230 7.0E-5 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS32740 12dadc7f0f3e68d6dbbb0fe611a8f56f 277 PRINTS PR00412 Epoxide hydrolase signature 95 108 7.0E-5 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS32740 12dadc7f0f3e68d6dbbb0fe611a8f56f 277 SUPERFAMILY SSF53474 6 268 2.81E-54 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS32740 12dadc7f0f3e68d6dbbb0fe611a8f56f 277 PRINTS PR00111 Alpha/beta hydrolase fold signature 50 65 9.5E-9 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS32740 12dadc7f0f3e68d6dbbb0fe611a8f56f 277 PRINTS PR00111 Alpha/beta hydrolase fold signature 216 230 9.5E-9 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS32740 12dadc7f0f3e68d6dbbb0fe611a8f56f 277 PRINTS PR00111 Alpha/beta hydrolase fold signature 95 108 9.5E-9 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS16310 55b57f89fdf44837fb2c1ff51cae9ee4 124 Pfam PF05331 Protein of unknown function (DUF742) 12 120 7.8E-29 T 09-03-2017 IPR007995 Protein of unknown function DUF742 TK78_RS16310 55b57f89fdf44837fb2c1ff51cae9ee4 124 SUPERFAMILY SSF46785 53 102 8.49E-5 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS33330 01ec1c2252139307f7d20e56da99f0fc 348 SUPERFAMILY SSF53807 59 341 1.18E-40 T 09-03-2017 TK78_RS33330 01ec1c2252139307f7d20e56da99f0fc 348 Gene3D G3DSA:3.40.50.1980 59 204 1.5E-12 T 09-03-2017 TK78_RS33330 01ec1c2252139307f7d20e56da99f0fc 348 Pfam PF01497 Periplasmic binding protein 64 319 1.9E-38 T 09-03-2017 IPR002491 ABC transporter periplasmic binding domain GO:0005488 TK78_RS33330 01ec1c2252139307f7d20e56da99f0fc 348 Gene3D G3DSA:3.40.50.1980 207 341 6.7E-25 T 09-03-2017 TK78_RS20775 3843b9b4d57d56c3ba7d38c5b80d0cd9 236 Gene3D G3DSA:1.10.357.10 36 225 1.8E-40 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS20775 3843b9b4d57d56c3ba7d38c5b80d0cd9 236 SUPERFAMILY SSF48498 112 219 9.34E-32 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS20775 3843b9b4d57d56c3ba7d38c5b80d0cd9 236 SUPERFAMILY SSF46689 34 116 8.25E-16 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS20775 3843b9b4d57d56c3ba7d38c5b80d0cd9 236 Pfam PF00440 Bacterial regulatory proteins, tetR family 47 92 1.9E-11 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS20775 3843b9b4d57d56c3ba7d38c5b80d0cd9 236 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 47 60 1.4E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS20775 3843b9b4d57d56c3ba7d38c5b80d0cd9 236 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 67 90 1.4E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS07570 46535180fe2c957c8beb9fe59fcc5524 127 SUPERFAMILY SSF47413 3 73 1.24E-13 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS07570 46535180fe2c957c8beb9fe59fcc5524 127 Gene3D G3DSA:1.10.260.40 8 73 1.6E-15 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS07570 46535180fe2c957c8beb9fe59fcc5524 127 SMART SM00530 11 66 1.4E-9 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS07570 46535180fe2c957c8beb9fe59fcc5524 127 Pfam PF13560 Helix-turn-helix domain 8 65 3.7E-11 T 09-03-2017 TK78_RS02175 40a49ac2f60ccc8166ea0ad6fac0cc25 162 Gene3D G3DSA:3.40.50.1000 7 139 4.3E-16 T 09-03-2017 IPR023214 HAD-like domain TK78_RS02175 40a49ac2f60ccc8166ea0ad6fac0cc25 162 SUPERFAMILY SSF56784 7 145 1.48E-18 T 09-03-2017 IPR023214 HAD-like domain TK78_RS17835 9ebe2f527df3263223006d559b1e621f 537 Gene3D G3DSA:3.40.50.620 242 351 1.4E-65 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS17835 9ebe2f527df3263223006d559b1e621f 537 Gene3D G3DSA:3.40.50.620 12 123 1.4E-65 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS17835 9ebe2f527df3263223006d559b1e621f 537 Gene3D G3DSA:1.10.730.10 353 532 4.4E-47 T 09-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS17835 9ebe2f527df3263223006d559b1e621f 537 PRINTS PR01041 Methionyl-tRNA synthetase signature 240 251 2.6E-31 T 09-03-2017 IPR014758 Methionyl-tRNA synthetase GO:0000166|GO:0004825|GO:0005524|GO:0005737|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 TK78_RS17835 9ebe2f527df3263223006d559b1e621f 537 PRINTS PR01041 Methionyl-tRNA synthetase signature 97 108 2.6E-31 T 09-03-2017 IPR014758 Methionyl-tRNA synthetase GO:0000166|GO:0004825|GO:0005524|GO:0005737|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 TK78_RS17835 9ebe2f527df3263223006d559b1e621f 537 PRINTS PR01041 Methionyl-tRNA synthetase signature 48 62 2.6E-31 T 09-03-2017 IPR014758 Methionyl-tRNA synthetase GO:0000166|GO:0004825|GO:0005524|GO:0005737|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 TK78_RS17835 9ebe2f527df3263223006d559b1e621f 537 PRINTS PR01041 Methionyl-tRNA synthetase signature 16 29 2.6E-31 T 09-03-2017 IPR014758 Methionyl-tRNA synthetase GO:0000166|GO:0004825|GO:0005524|GO:0005737|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 TK78_RS17835 9ebe2f527df3263223006d559b1e621f 537 PRINTS PR01041 Methionyl-tRNA synthetase signature 272 287 2.6E-31 T 09-03-2017 IPR014758 Methionyl-tRNA synthetase GO:0000166|GO:0004825|GO:0005524|GO:0005737|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 TK78_RS17835 9ebe2f527df3263223006d559b1e621f 537 PRINTS PR01041 Methionyl-tRNA synthetase signature 364 375 2.6E-31 T 09-03-2017 IPR014758 Methionyl-tRNA synthetase GO:0000166|GO:0004825|GO:0005524|GO:0005737|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 TK78_RS17835 9ebe2f527df3263223006d559b1e621f 537 SUPERFAMILY SSF47323 365 532 1.16E-32 T 09-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS17835 9ebe2f527df3263223006d559b1e621f 537 Gene3D G3DSA:2.170.220.10 126 241 5.5E-44 T 09-03-2017 TK78_RS17835 9ebe2f527df3263223006d559b1e621f 537 Pfam PF09334 tRNA synthetases class I (M) 14 376 1.9E-105 T 09-03-2017 IPR015413 Methionyl/Leucyl tRNA synthetase GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS17835 9ebe2f527df3263223006d559b1e621f 537 Hamap MF_01228 Methionine--tRNA ligase [metG]. 6 526 45.881 T 09-03-2017 IPR023457 Methionine-tRNA synthetase, type 2 GO:0004825 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 TK78_RS17835 9ebe2f527df3263223006d559b1e621f 537 SUPERFAMILY SSF52374 13 361 1.1E-103 T 09-03-2017 TK78_RS17835 9ebe2f527df3263223006d559b1e621f 537 TIGRFAM TIGR00398 metG: methionine--tRNA ligase 15 504 8.9E-148 T 09-03-2017 IPR014758 Methionyl-tRNA synthetase GO:0000166|GO:0004825|GO:0005524|GO:0005737|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 TK78_RS07040 cd883ec0fa25dcdd1dc1ebc3f4c55aad 305 Gene3D G3DSA:3.40.50.1820 11 296 2.5E-53 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS07040 cd883ec0fa25dcdd1dc1ebc3f4c55aad 305 PIRSF PIRSF005539 3 303 3.2E-119 T 09-03-2017 IPR005945 Proline-specific peptidase GO:0006508|GO:0008233 KEGG: 00330+3.4.11.5 TK78_RS07040 cd883ec0fa25dcdd1dc1ebc3f4c55aad 305 PRINTS PR00793 Prolyl aminopeptidase (S33) family signature 33 41 1.7E-10 T 09-03-2017 IPR002410 Peptidase S33 GO:0006508|GO:0008233 KEGG: 00330+3.4.11.5 TK78_RS07040 cd883ec0fa25dcdd1dc1ebc3f4c55aad 305 PRINTS PR00793 Prolyl aminopeptidase (S33) family signature 60 71 1.7E-10 T 09-03-2017 IPR002410 Peptidase S33 GO:0006508|GO:0008233 KEGG: 00330+3.4.11.5 TK78_RS07040 cd883ec0fa25dcdd1dc1ebc3f4c55aad 305 PRINTS PR00793 Prolyl aminopeptidase (S33) family signature 106 120 1.7E-10 T 09-03-2017 IPR002410 Peptidase S33 GO:0006508|GO:0008233 KEGG: 00330+3.4.11.5 TK78_RS07040 cd883ec0fa25dcdd1dc1ebc3f4c55aad 305 TIGRFAM TIGR01250 pro_imino_pep_2: proline-specific peptidase 9 295 3.4E-79 T 09-03-2017 IPR005945 Proline-specific peptidase GO:0006508|GO:0008233 KEGG: 00330+3.4.11.5 TK78_RS07040 cd883ec0fa25dcdd1dc1ebc3f4c55aad 305 SUPERFAMILY SSF53474 14 296 1.31E-58 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS07040 cd883ec0fa25dcdd1dc1ebc3f4c55aad 305 Pfam PF00561 alpha/beta hydrolase fold 31 284 3.4E-21 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS25495 af3a11f6d10ad5ff72d937f58769a97b 413 TIGRFAM TIGR00045 TIGR00045: glycerate kinase 7 394 2.6E-128 T 09-03-2017 IPR004381 Glycerate kinase GO:0008887|GO:0031388 TK78_RS25495 af3a11f6d10ad5ff72d937f58769a97b 413 Pfam PF02595 Glycerate kinase family 8 393 1.2E-126 T 09-03-2017 IPR004381 Glycerate kinase GO:0008887|GO:0031388 TK78_RS25495 af3a11f6d10ad5ff72d937f58769a97b 413 PIRSF PIRSF006078 6 397 2.2E-102 T 09-03-2017 IPR004381 Glycerate kinase GO:0008887|GO:0031388 TK78_RS25495 af3a11f6d10ad5ff72d937f58769a97b 413 Gene3D G3DSA:3.90.1510.10 48 294 8.5E-78 T 09-03-2017 IPR018193 Glycerate kinase, flavodoxin-like domain GO:0008887|GO:0031388 TK78_RS25495 af3a11f6d10ad5ff72d937f58769a97b 413 SUPERFAMILY SSF110738 7 395 4.18E-112 T 09-03-2017 IPR004381 Glycerate kinase GO:0008887|GO:0031388 TK78_RS11705 a9ddabbf711ffdb6039ec7721c1daf24 273 SUPERFAMILY SSF48498 105 271 2.67E-22 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS11705 a9ddabbf711ffdb6039ec7721c1daf24 273 Gene3D G3DSA:1.10.357.10 27 271 7.6E-56 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS11705 a9ddabbf711ffdb6039ec7721c1daf24 273 Pfam PF00440 Bacterial regulatory proteins, tetR family 41 85 2.0E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS11705 a9ddabbf711ffdb6039ec7721c1daf24 273 SUPERFAMILY SSF46689 32 96 5.64E-12 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS11705 a9ddabbf711ffdb6039ec7721c1daf24 273 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 100 209 2.6E-11 T 09-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 TK78_RS13620 c3ed957689137e0a79f8aba1ce16d43c 289 Pfam PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 28 175 2.2E-30 T 09-03-2017 IPR001457 NADH:ubiquinone/plastoquinone oxidoreductase, chain 6 GO:0008137|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS15435 ea6f3986a588bf2c014206b6cfa98da2 298 SUPERFAMILY SSF55811 25 82 1.16E-13 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS15435 ea6f3986a588bf2c014206b6cfa98da2 298 SUPERFAMILY SSF55811 111 122 1.16E-13 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS15435 ea6f3986a588bf2c014206b6cfa98da2 298 SUPERFAMILY SSF55811 167 233 1.16E-13 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS15435 ea6f3986a588bf2c014206b6cfa98da2 298 Gene3D G3DSA:3.90.79.10 166 238 1.4E-16 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS15435 ea6f3986a588bf2c014206b6cfa98da2 298 Gene3D G3DSA:3.90.79.10 26 121 1.4E-16 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS09475 c00c761e544a8607b11f9aacb79e7985 411 Gene3D G3DSA:2.130.10.10 88 356 5.7E-12 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS09475 c00c761e544a8607b11f9aacb79e7985 411 SUPERFAMILY SSF50969 135 367 3.22E-13 T 09-03-2017 IPR011044 Quinoprotein amine dehydrogenase, beta chain-like TK78_RS20950 1a25629e47f860791cee535a0af0817c 457 Pfam PF03583 Secretory lipase 148 435 8.2E-41 T 09-03-2017 IPR005152 Lipase, secreted GO:0004806|GO:0016042 KEGG: 00561+3.1.1.3|MetaCyc: PWY-6857 TK78_RS20950 1a25629e47f860791cee535a0af0817c 457 SUPERFAMILY SSF53474 313 430 1.11E-8 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS20950 1a25629e47f860791cee535a0af0817c 457 SUPERFAMILY SSF53474 154 258 1.11E-8 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS20950 1a25629e47f860791cee535a0af0817c 457 Gene3D G3DSA:3.40.50.1820 158 281 1.9E-4 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS20950 1a25629e47f860791cee535a0af0817c 457 Gene3D G3DSA:3.40.50.1820 369 429 1.9E-4 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS18890 24665677740e4fda590023e7f1aadaef 321 SUPERFAMILY SSF103025 22 240 1.4E-53 T 09-03-2017 TK78_RS18890 24665677740e4fda590023e7f1aadaef 321 Gene3D G3DSA:2.40.30.110 241 305 7.9E-4 T 09-03-2017 IPR013977 Glycine cleavage T-protein, C-terminal barrel domain KEGG: 00260+2.1.2.10|KEGG: 00670+2.1.2.10 TK78_RS18890 24665677740e4fda590023e7f1aadaef 321 Gene3D G3DSA:3.30.70.1400 47 131 2.8E-13 T 09-03-2017 TK78_RS18890 24665677740e4fda590023e7f1aadaef 321 Pfam PF08669 Glycine cleavage T-protein C-terminal barrel domain 224 303 1.2E-8 T 09-03-2017 IPR013977 Glycine cleavage T-protein, C-terminal barrel domain KEGG: 00260+2.1.2.10|KEGG: 00670+2.1.2.10 TK78_RS18890 24665677740e4fda590023e7f1aadaef 321 Pfam PF01571 Aminomethyltransferase folate-binding domain 22 141 5.3E-17 T 09-03-2017 IPR006222 Glycine cleavage T-protein-like, N-terminal TK78_RS18890 24665677740e4fda590023e7f1aadaef 321 TIGRFAM TIGR03317 ygfZ_signature: folate-binding protein YgfZ 186 250 1.0E-20 T 09-03-2017 IPR017703 YgfZ/GcvT conserved site TK78_RS07850 24463efc56998ba4829e3fcc727e7dd0 309 Pfam PF04655 Aminoglycoside/hydroxyurea antibiotic resistance kinase 44 292 8.3E-61 T 09-03-2017 IPR006748 Aminoglycoside/hydroxyurea antibiotic resistance kinase GO:0006468|GO:0016773|GO:0019748 TK78_RS07850 24463efc56998ba4829e3fcc727e7dd0 309 SUPERFAMILY SSF56112 29 291 2.86E-12 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS01735 6926306cdb0b43f9fb77314ff1bfc849 101 Hamap MF_00537 30S ribosomal protein S14 [rpsN]. 1 101 25.588 T 09-03-2017 IPR023036 Ribosomal protein S14, bacterial/plastid TK78_RS01735 6926306cdb0b43f9fb77314ff1bfc849 101 Pfam PF00253 Ribosomal protein S14p/S29e 48 100 5.8E-23 T 09-03-2017 IPR001209 Ribosomal protein S14 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS01735 6926306cdb0b43f9fb77314ff1bfc849 101 SUPERFAMILY SSF57716 2 101 1.14E-32 T 09-03-2017 TK78_RS01735 6926306cdb0b43f9fb77314ff1bfc849 101 Gene3D G3DSA:4.10.830.10 42 101 1.5E-26 T 09-03-2017 TK78_RS29900 b012bc894bcd674b1c6b28bacdf7acab 223 SUPERFAMILY SSF161098 8 204 7.85E-43 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS29900 b012bc894bcd674b1c6b28bacdf7acab 223 Gene3D G3DSA:1.10.3720.10 7 213 4.4E-39 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS29900 b012bc894bcd674b1c6b28bacdf7acab 223 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 32 218 5.2E-21 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS15005 60d9b91372886ff1f7478b0ed6042141 431 TIGRFAM TIGR00260 thrC: threonine synthase 72 403 8.0E-81 T 09-03-2017 IPR004450 Threonine synthase-like TK78_RS15005 60d9b91372886ff1f7478b0ed6042141 431 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 94 397 1.7E-62 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS15005 60d9b91372886ff1f7478b0ed6042141 431 Gene3D G3DSA:3.40.50.1100 212 410 7.0E-34 T 09-03-2017 TK78_RS15005 60d9b91372886ff1f7478b0ed6042141 431 Gene3D G3DSA:3.40.50.1100 127 211 6.4E-29 T 09-03-2017 TK78_RS15005 60d9b91372886ff1f7478b0ed6042141 431 SUPERFAMILY SSF53686 19 408 9.95E-88 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS32975 3ff428f62cd65b6946a26ab686ddfcb1 301 Gene3D G3DSA:2.60.120.260 42 128 1.0E-4 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS25380 95dc81f699f015ac7b4bff85b87ddef8 410 SUPERFAMILY SSF103473 7 404 5.62E-62 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS25380 95dc81f699f015ac7b4bff85b87ddef8 410 Pfam PF07690 Major Facilitator Superfamily 35 366 2.5E-40 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS25380 95dc81f699f015ac7b4bff85b87ddef8 410 Gene3D G3DSA:1.20.1250.20 223 401 6.0E-22 T 09-03-2017 TK78_RS25380 95dc81f699f015ac7b4bff85b87ddef8 410 Gene3D G3DSA:1.20.1250.20 26 207 2.4E-24 T 09-03-2017 TK78_RS14700 a5afc51a12bdc5c55b280d6a35b3d116 294 SUPERFAMILY SSF52540 6 235 3.37E-59 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS14700 a5afc51a12bdc5c55b280d6a35b3d116 294 Gene3D G3DSA:3.40.50.300 8 246 6.3E-64 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS14700 a5afc51a12bdc5c55b280d6a35b3d116 294 ProSitePatterns PS00211 ABC transporters family signature. 145 159 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS14700 a5afc51a12bdc5c55b280d6a35b3d116 294 Pfam PF00005 ABC transporter 25 172 6.4E-31 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS14700 a5afc51a12bdc5c55b280d6a35b3d116 294 SMART SM00382 33 227 1.8E-16 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS32200 ac3c61d4913aa0f8be4e5c79c7acd795 223 Gene3D G3DSA:1.10.3720.10 22 206 1.2E-26 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS32200 ac3c61d4913aa0f8be4e5c79c7acd795 223 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 47 216 1.1E-20 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS32200 ac3c61d4913aa0f8be4e5c79c7acd795 223 SUPERFAMILY SSF161098 22 205 2.09E-34 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS23975 4eece34703a462b0219aa67bf178b9d7 144 Pfam PF00583 Acetyltransferase (GNAT) family 42 121 1.2E-15 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS23975 4eece34703a462b0219aa67bf178b9d7 144 Gene3D G3DSA:3.40.630.30 11 126 6.6E-24 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS23975 4eece34703a462b0219aa67bf178b9d7 144 SUPERFAMILY SSF55729 17 127 1.83E-23 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS08365 66c187d373b082ee49f3b9262c87ec8c 475 ProSitePatterns PS01244 Aconitase family signature 2. 399 412 - T 09-03-2017 IPR018136 Aconitase family, 4Fe-4S cluster binding site KEGG: 00290+4.2.1.33 TK78_RS08365 66c187d373b082ee49f3b9262c87ec8c 475 TIGRFAM TIGR00170 leuC: 3-isopropylmalate dehydratase, large subunit 1 460 3.6E-224 T 09-03-2017 IPR004430 3-isopropylmalate dehydratase, large subunit GO:0003861|GO:0009098|GO:0051539 KEGG: 00290+4.2.1.33 TK78_RS08365 66c187d373b082ee49f3b9262c87ec8c 475 ProSitePatterns PS00450 Aconitase family signature 1. 339 355 - T 09-03-2017 IPR018136 Aconitase family, 4Fe-4S cluster binding site KEGG: 00290+4.2.1.33 TK78_RS08365 66c187d373b082ee49f3b9262c87ec8c 475 Hamap MF_01026 3-isopropylmalate dehydratase large subunit [leuC]. 1 466 59.132 T 09-03-2017 IPR004430 3-isopropylmalate dehydratase, large subunit GO:0003861|GO:0009098|GO:0051539 KEGG: 00290+4.2.1.33 TK78_RS08365 66c187d373b082ee49f3b9262c87ec8c 475 SUPERFAMILY SSF53732 1 465 6.15E-163 T 09-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS08365 66c187d373b082ee49f3b9262c87ec8c 475 Gene3D G3DSA:3.30.499.10 322 466 1.0E-57 T 09-03-2017 IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS08365 66c187d373b082ee49f3b9262c87ec8c 475 PRINTS PR00415 Aconitase family signature 343 354 1.5E-46 T 09-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS08365 66c187d373b082ee49f3b9262c87ec8c 475 PRINTS PR00415 Aconitase family signature 108 116 1.5E-46 T 09-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS08365 66c187d373b082ee49f3b9262c87ec8c 475 PRINTS PR00415 Aconitase family signature 209 222 1.5E-46 T 09-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS08365 66c187d373b082ee49f3b9262c87ec8c 475 PRINTS PR00415 Aconitase family signature 399 412 1.5E-46 T 09-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS08365 66c187d373b082ee49f3b9262c87ec8c 475 PRINTS PR00415 Aconitase family signature 119 132 1.5E-46 T 09-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS08365 66c187d373b082ee49f3b9262c87ec8c 475 PRINTS PR00415 Aconitase family signature 82 95 1.5E-46 T 09-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS08365 66c187d373b082ee49f3b9262c87ec8c 475 PRINTS PR00415 Aconitase family signature 133 148 1.5E-46 T 09-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS08365 66c187d373b082ee49f3b9262c87ec8c 475 PRINTS PR00415 Aconitase family signature 195 208 1.5E-46 T 09-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS08365 66c187d373b082ee49f3b9262c87ec8c 475 PRINTS PR00415 Aconitase family signature 286 300 1.5E-46 T 09-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS08365 66c187d373b082ee49f3b9262c87ec8c 475 Gene3D G3DSA:3.40.1060.10 155 288 2.5E-40 T 09-03-2017 IPR015932 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2 GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS08365 66c187d373b082ee49f3b9262c87ec8c 475 Gene3D G3DSA:3.30.499.10 2 154 2.1E-22 T 09-03-2017 IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS08365 66c187d373b082ee49f3b9262c87ec8c 475 Pfam PF00330 Aconitase family (aconitate hydratase) 7 457 2.2E-151 T 09-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 TK78_RS14665 e08ec23d4766a2c1b5c9cbfd923d3d33 237 Hamap MF_00991 Futalosine hydrolase [mqnB]. 16 224 24.953 T 09-03-2017 IPR019963 Futalosine hydrolase GO:0009234|GO:0016799 KEGG: 00130+3.2.2.26|MetaCyc: PWY-7374 TK78_RS14665 e08ec23d4766a2c1b5c9cbfd923d3d33 237 TIGRFAM TIGR03664 fut_nucase: futalosine hydrolase 3 219 4.9E-66 T 09-03-2017 IPR019963 Futalosine hydrolase GO:0009234|GO:0016799 KEGG: 00130+3.2.2.26|MetaCyc: PWY-7374 TK78_RS14665 e08ec23d4766a2c1b5c9cbfd923d3d33 237 SUPERFAMILY SSF53167 2 207 1.17E-24 T 09-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 TK78_RS14665 e08ec23d4766a2c1b5c9cbfd923d3d33 237 Pfam PF01048 Phosphorylase superfamily 45 223 3.7E-11 T 09-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 TK78_RS14665 e08ec23d4766a2c1b5c9cbfd923d3d33 237 Gene3D G3DSA:3.40.50.1580 2 233 6.8E-53 T 09-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 TK78_RS20620 ad978fdf77cb9c29ca741d2d5b8154aa 371 SUPERFAMILY SSF101478 16 346 1.1E-50 T 09-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 TK78_RS20620 ad978fdf77cb9c29ca741d2d5b8154aa 371 Pfam PF03747 ADP-ribosylglycohydrolase 23 325 2.4E-50 T 09-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 TK78_RS20060 2f08fe935051ff5b8db64e95bba83e90 188 SUPERFAMILY SSF53597 4 186 5.76E-31 T 09-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 TK78_RS20060 2f08fe935051ff5b8db64e95bba83e90 188 Gene3D G3DSA:3.40.430.10 3 185 8.1E-28 T 09-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 TK78_RS20060 2f08fe935051ff5b8db64e95bba83e90 188 Pfam PF01872 RibD C-terminal domain 4 179 1.7E-25 T 09-03-2017 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 TK78_RS17795 2b3a0b2618ba47c2a41ca7cc19522d98 432 Gene3D G3DSA:2.30.250.10 91 217 1.2E-38 T 09-03-2017 IPR023358 Peptidase M18, domain 2 GO:0004177 TK78_RS17795 2b3a0b2618ba47c2a41ca7cc19522d98 432 PRINTS PR00932 Aminopeptidase I zinc metalloprotease (M18) signature 113 133 1.9E-36 T 09-03-2017 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 TK78_RS17795 2b3a0b2618ba47c2a41ca7cc19522d98 432 PRINTS PR00932 Aminopeptidase I zinc metalloprotease (M18) signature 397 412 1.9E-36 T 09-03-2017 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 TK78_RS17795 2b3a0b2618ba47c2a41ca7cc19522d98 432 PRINTS PR00932 Aminopeptidase I zinc metalloprotease (M18) signature 80 96 1.9E-36 T 09-03-2017 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 TK78_RS17795 2b3a0b2618ba47c2a41ca7cc19522d98 432 PRINTS PR00932 Aminopeptidase I zinc metalloprotease (M18) signature 308 324 1.9E-36 T 09-03-2017 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 TK78_RS17795 2b3a0b2618ba47c2a41ca7cc19522d98 432 PRINTS PR00932 Aminopeptidase I zinc metalloprotease (M18) signature 265 283 1.9E-36 T 09-03-2017 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 TK78_RS17795 2b3a0b2618ba47c2a41ca7cc19522d98 432 Gene3D G3DSA:3.40.630.10 220 430 7.7E-103 T 09-03-2017 TK78_RS17795 2b3a0b2618ba47c2a41ca7cc19522d98 432 Gene3D G3DSA:3.40.630.10 10 90 7.7E-103 T 09-03-2017 TK78_RS17795 2b3a0b2618ba47c2a41ca7cc19522d98 432 Hamap MF_00467 Probable M18 family aminopeptidase 2 [apeB]. 1 432 56.755 T 09-03-2017 IPR022984 M18 family aminopeptidase 2, putative GO:0004177 TK78_RS17795 2b3a0b2618ba47c2a41ca7cc19522d98 432 SUPERFAMILY SSF53187 211 430 2.06E-92 T 09-03-2017 TK78_RS17795 2b3a0b2618ba47c2a41ca7cc19522d98 432 SUPERFAMILY SSF53187 9 91 2.06E-92 T 09-03-2017 TK78_RS17795 2b3a0b2618ba47c2a41ca7cc19522d98 432 SUPERFAMILY SSF101821 92 210 1.28E-30 T 09-03-2017 TK78_RS17795 2b3a0b2618ba47c2a41ca7cc19522d98 432 Pfam PF02127 Aminopeptidase I zinc metalloprotease (M18) 18 429 8.2E-122 T 09-03-2017 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 TK78_RS21120 c7a9ba3dbb4822bbbae0b41a33a1f17d 400 Gene3D G3DSA:1.20.1250.20 3 182 2.5E-17 T 09-03-2017 TK78_RS21120 c7a9ba3dbb4822bbbae0b41a33a1f17d 400 Pfam PF07690 Major Facilitator Superfamily 13 342 3.1E-20 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS21120 c7a9ba3dbb4822bbbae0b41a33a1f17d 400 SUPERFAMILY SSF103473 3 375 9.16E-42 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS21120 c7a9ba3dbb4822bbbae0b41a33a1f17d 400 Gene3D G3DSA:1.20.1250.20 204 378 1.3E-12 T 09-03-2017 TK78_RS33535 e6d07e8b0d33f1cb1a7f9d2a8fee9d13 345 Pfam PF00877 NlpC/P60 family 243 336 1.9E-24 T 09-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain TK78_RS33535 e6d07e8b0d33f1cb1a7f9d2a8fee9d13 345 SUPERFAMILY SSF54001 227 333 5.89E-35 T 09-03-2017 TK78_RS33535 e6d07e8b0d33f1cb1a7f9d2a8fee9d13 345 Gene3D G3DSA:3.90.1720.10 224 333 7.6E-38 T 09-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain TK78_RS08925 771229b1a5e7b99ef1e08a60fa84968d 296 Pfam PF13622 Thioesterase-like superfamily 48 290 1.5E-40 T 09-03-2017 TK78_RS08925 771229b1a5e7b99ef1e08a60fa84968d 296 SUPERFAMILY SSF54637 154 289 4.15E-8 T 09-03-2017 IPR029069 HotDog domain TK78_RS08925 771229b1a5e7b99ef1e08a60fa84968d 296 SUPERFAMILY SSF54637 44 117 4.98E-9 T 09-03-2017 IPR029069 HotDog domain TK78_RS33165 e98d95170d35843b30c843f4b4f32659 211 Pfam PF01810 LysE type translocator 16 207 8.2E-27 T 09-03-2017 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 TK78_RS33165 e98d95170d35843b30c843f4b4f32659 211 PIRSF PIRSF006324 1 210 1.5E-51 T 09-03-2017 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 TK78_RS30120 e8c7fda0eeecf1606562488dc0346cf0 361 Gene3D G3DSA:3.40.50.300 38 190 2.5E-30 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS30120 e8c7fda0eeecf1606562488dc0346cf0 361 Pfam PF05496 Holliday junction DNA helicase ruvB N-terminus 22 253 2.9E-109 T 09-03-2017 IPR008824 Holliday junction DNA helicase ruvB, N-terminal GO:0006281|GO:0006310|GO:0009378 TK78_RS30120 e8c7fda0eeecf1606562488dc0346cf0 361 SUPERFAMILY SSF52540 38 269 1.78E-49 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS30120 e8c7fda0eeecf1606562488dc0346cf0 361 ProDom PD005323 DNA HELICASE HOLLIDAY JUNCTION RUVB NUCLEOTIDE-BINDING ATP-BINDING SOS RECOMBINATION RESPONSE 270 345 4.0E-23 T 09-03-2017 IPR008823 DNA helicase, Holliday junction RuvB type, C-terminal GO:0003677|GO:0006281|GO:0006310|GO:0009378 TK78_RS30120 e8c7fda0eeecf1606562488dc0346cf0 361 Gene3D G3DSA:1.10.10.10 275 345 1.2E-30 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS30120 e8c7fda0eeecf1606562488dc0346cf0 361 Gene3D G3DSA:1.10.8.60 201 273 2.3E-32 T 09-03-2017 TK78_RS30120 e8c7fda0eeecf1606562488dc0346cf0 361 Hamap MF_00016 Holliday junction ATP-dependent DNA helicase RuvB [ruvB]. 1 361 162.145 T 09-03-2017 IPR004605 DNA helicase, Holliday junction RuvB type GO:0003677|GO:0005524|GO:0006281|GO:0006310|GO:0009378 TK78_RS30120 e8c7fda0eeecf1606562488dc0346cf0 361 Pfam PF05491 Holliday junction DNA helicase ruvB C-terminus 271 344 5.2E-29 T 09-03-2017 IPR008823 DNA helicase, Holliday junction RuvB type, C-terminal GO:0003677|GO:0006281|GO:0006310|GO:0009378 TK78_RS30120 e8c7fda0eeecf1606562488dc0346cf0 361 TIGRFAM TIGR00635 ruvB: Holliday junction DNA helicase RuvB 42 344 1.7E-134 T 09-03-2017 IPR004605 DNA helicase, Holliday junction RuvB type GO:0003677|GO:0005524|GO:0006281|GO:0006310|GO:0009378 TK78_RS30120 e8c7fda0eeecf1606562488dc0346cf0 361 SMART SM00382 69 202 3.3E-10 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS30120 e8c7fda0eeecf1606562488dc0346cf0 361 SUPERFAMILY SSF46785 275 348 2.04E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS33800 25728823a38a84024a93ad6d807012dd 289 Gene3D G3DSA:1.10.1040.10 192 286 9.5E-32 T 09-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 TK78_RS33800 25728823a38a84024a93ad6d807012dd 289 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 190 284 5.7E-30 T 09-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS33800 25728823a38a84024a93ad6d807012dd 289 Gene3D G3DSA:3.40.50.720 5 191 1.4E-55 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS33800 25728823a38a84024a93ad6d807012dd 289 SUPERFAMILY SSF51735 5 187 3.0E-47 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS33800 25728823a38a84024a93ad6d807012dd 289 PIRSF PIRSF000105 1 289 4.0E-80 T 09-03-2017 IPR022694 3-hydroxyacyl-CoA dehydrogenase GO:0003857|GO:0006631|GO:0055114|GO:0070403 TK78_RS33800 25728823a38a84024a93ad6d807012dd 289 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 8 187 2.6E-56 T 09-03-2017 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS33800 25728823a38a84024a93ad6d807012dd 289 SUPERFAMILY SSF48179 190 288 8.5E-30 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS27830 d09b72686c892f63c36babd89858940c 142 PRINTS PR00162 Rieske 2Fe-2S subunit signature 99 111 8.6E-9 T 09-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 TK78_RS27830 d09b72686c892f63c36babd89858940c 142 PRINTS PR00162 Rieske 2Fe-2S subunit signature 112 124 8.6E-9 T 09-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 TK78_RS27830 d09b72686c892f63c36babd89858940c 142 PRINTS PR00162 Rieske 2Fe-2S subunit signature 79 90 8.6E-9 T 09-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 TK78_RS27830 d09b72686c892f63c36babd89858940c 142 SUPERFAMILY SSF50022 14 138 3.93E-27 T 09-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 TK78_RS27830 d09b72686c892f63c36babd89858940c 142 Gene3D G3DSA:2.102.10.10 7 137 2.6E-28 T 09-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 TK78_RS27830 d09b72686c892f63c36babd89858940c 142 Pfam PF00355 Rieske [2Fe-2S] domain 46 128 3.3E-16 T 09-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 TK78_RS28800 f9ecda962043104643a768aaaadfde5b 312 Gene3D G3DSA:3.40.190.10 258 297 4.9E-27 T 09-03-2017 TK78_RS28800 f9ecda962043104643a768aaaadfde5b 312 Gene3D G3DSA:3.40.190.10 68 148 4.9E-27 T 09-03-2017 TK78_RS28800 f9ecda962043104643a768aaaadfde5b 312 Gene3D G3DSA:3.40.190.10 149 252 2.1E-15 T 09-03-2017 TK78_RS28800 f9ecda962043104643a768aaaadfde5b 312 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3 72 296 8.9E-41 T 09-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF TK78_RS28800 f9ecda962043104643a768aaaadfde5b 312 SMART SM00062 71 298 9.6E-31 T 09-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF TK78_RS28800 f9ecda962043104643a768aaaadfde5b 312 SUPERFAMILY SSF53850 61 296 7.17E-49 T 09-03-2017 TK78_RS28800 f9ecda962043104643a768aaaadfde5b 312 SUPERFAMILY SSF53850 7 24 7.17E-49 T 09-03-2017 TK78_RS13775 fa03677d81aae8a0f52cd4c9af6bfdf6 406 Pfam PF04909 Amidohydrolase 98 397 1.0E-39 T 09-03-2017 IPR006680 Amidohydrolase-related GO:0016787 TK78_RS13775 fa03677d81aae8a0f52cd4c9af6bfdf6 406 SUPERFAMILY SSF51556 6 34 8.66E-68 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS13775 fa03677d81aae8a0f52cd4c9af6bfdf6 406 SUPERFAMILY SSF51556 98 397 8.66E-68 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS13775 fa03677d81aae8a0f52cd4c9af6bfdf6 406 Gene3D G3DSA:3.20.20.140 6 34 1.3E-62 T 09-03-2017 TK78_RS13775 fa03677d81aae8a0f52cd4c9af6bfdf6 406 Gene3D G3DSA:3.20.20.140 85 398 1.3E-62 T 09-03-2017 TK78_RS16690 17082dfbd5c7f4bd54068a4069c55a1a 411 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 109 117 3.2E-8 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS16690 17082dfbd5c7f4bd54068a4069c55a1a 411 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 12 34 3.2E-8 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS16690 17082dfbd5c7f4bd54068a4069c55a1a 411 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 151 175 3.2E-8 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS16690 17082dfbd5c7f4bd54068a4069c55a1a 411 Gene3D G3DSA:3.50.50.60 117 316 1.2E-28 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS16690 17082dfbd5c7f4bd54068a4069c55a1a 411 Gene3D G3DSA:3.50.50.60 10 116 7.3E-19 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS16690 17082dfbd5c7f4bd54068a4069c55a1a 411 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 11 294 6.6E-37 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS16690 17082dfbd5c7f4bd54068a4069c55a1a 411 SUPERFAMILY SSF51905 6 316 2.44E-32 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS16690 17082dfbd5c7f4bd54068a4069c55a1a 411 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 108 126 3.5E-14 T 09-03-2017 TK78_RS16690 17082dfbd5c7f4bd54068a4069c55a1a 411 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 155 173 3.5E-14 T 09-03-2017 TK78_RS16690 17082dfbd5c7f4bd54068a4069c55a1a 411 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 262 284 3.5E-14 T 09-03-2017 TK78_RS16690 17082dfbd5c7f4bd54068a4069c55a1a 411 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 13 32 3.5E-14 T 09-03-2017 TK78_RS09405 3c4c3aafdc2917fedd165a08ddd07df6 476 SUPERFAMILY SSF50800 70 164 8.37E-26 T 09-03-2017 IPR011037 Pyruvate kinase-like, insert domain TK78_RS09405 3c4c3aafdc2917fedd165a08ddd07df6 476 Pfam PF02887 Pyruvate kinase, alpha/beta domain 356 468 8.0E-29 T 09-03-2017 IPR015795 Pyruvate kinase, C-terminal KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS09405 3c4c3aafdc2917fedd165a08ddd07df6 476 TIGRFAM TIGR01064 pyruv_kin: pyruvate kinase 2 469 3.9E-167 T 09-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS09405 3c4c3aafdc2917fedd165a08ddd07df6 476 Gene3D G3DSA:2.40.33.10 73 166 2.8E-29 T 09-03-2017 IPR015806 Pyruvate kinase, beta-barrel insert domain GO:0004743|GO:0006096 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS09405 3c4c3aafdc2917fedd165a08ddd07df6 476 SUPERFAMILY SSF51621 1 74 3.84E-96 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS09405 3c4c3aafdc2917fedd165a08ddd07df6 476 SUPERFAMILY SSF51621 154 337 3.84E-96 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS09405 3c4c3aafdc2917fedd165a08ddd07df6 476 Pfam PF00224 Pyruvate kinase, barrel domain 1 337 1.4E-125 T 09-03-2017 IPR015793 Pyruvate kinase, barrel GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS09405 3c4c3aafdc2917fedd165a08ddd07df6 476 Gene3D G3DSA:3.20.20.60 167 322 1.2E-103 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS09405 3c4c3aafdc2917fedd165a08ddd07df6 476 Gene3D G3DSA:3.20.20.60 2 72 1.2E-103 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS09405 3c4c3aafdc2917fedd165a08ddd07df6 476 ProSitePatterns PS00110 Pyruvate kinase active site signature. 212 224 - T 09-03-2017 IPR018209 Pyruvate kinase, active site GO:0004743|GO:0006096 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS09405 3c4c3aafdc2917fedd165a08ddd07df6 476 SUPERFAMILY SSF52935 320 470 8.9E-40 T 09-03-2017 IPR015795 Pyruvate kinase, C-terminal KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS09405 3c4c3aafdc2917fedd165a08ddd07df6 476 Gene3D G3DSA:3.40.1380.20 323 468 1.9E-43 T 09-03-2017 IPR015794 Pyruvate kinase, alpha/beta GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS09405 3c4c3aafdc2917fedd165a08ddd07df6 476 PRINTS PR01050 Pyruvate kinase family signature 59 75 2.4E-62 T 09-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS09405 3c4c3aafdc2917fedd165a08ddd07df6 476 PRINTS PR01050 Pyruvate kinase family signature 184 198 2.4E-62 T 09-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS09405 3c4c3aafdc2917fedd165a08ddd07df6 476 PRINTS PR01050 Pyruvate kinase family signature 291 309 2.4E-62 T 09-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS09405 3c4c3aafdc2917fedd165a08ddd07df6 476 PRINTS PR01050 Pyruvate kinase family signature 266 290 2.4E-62 T 09-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS09405 3c4c3aafdc2917fedd165a08ddd07df6 476 PRINTS PR01050 Pyruvate kinase family signature 214 240 2.4E-62 T 09-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS09405 3c4c3aafdc2917fedd165a08ddd07df6 476 PRINTS PR01050 Pyruvate kinase family signature 241 265 2.4E-62 T 09-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS09405 3c4c3aafdc2917fedd165a08ddd07df6 476 PRINTS PR01050 Pyruvate kinase family signature 310 326 2.4E-62 T 09-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TK78_RS14405 278737b5fcecc0eb173c34fdb669b82c 199 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 40 63 6.7E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS14405 278737b5fcecc0eb173c34fdb669b82c 199 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 19 32 6.7E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS14405 278737b5fcecc0eb173c34fdb669b82c 199 SUPERFAMILY SSF46689 7 82 1.23E-17 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS14405 278737b5fcecc0eb173c34fdb669b82c 199 SUPERFAMILY SSF48498 92 188 2.26E-15 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS14405 278737b5fcecc0eb173c34fdb669b82c 199 Pfam PF00440 Bacterial regulatory proteins, tetR family 19 65 6.6E-15 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS14405 278737b5fcecc0eb173c34fdb669b82c 199 Gene3D G3DSA:1.10.357.10 11 188 7.4E-37 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS14405 278737b5fcecc0eb173c34fdb669b82c 199 Pfam PF13977 Bacterial transcriptional repressor 98 195 3.8E-7 T 09-03-2017 TK78_RS12400 90ad838905ad54dffe1e4d872d026c5c 25 Pfam PF17199 Protein of unknown function (DUF5136) 1 25 1.2E-19 T 09-03-2017 TK78_RS30440 8978b8c225e544da664c22d5cb1ebca3 396 Pfam PF13412 Winged helix-turn-helix DNA-binding 11 56 6.8E-7 T 09-03-2017 TK78_RS30440 8978b8c225e544da664c22d5cb1ebca3 396 Gene3D G3DSA:3.30.420.40 78 216 3.4E-32 T 09-03-2017 TK78_RS30440 8978b8c225e544da664c22d5cb1ebca3 396 Gene3D G3DSA:3.30.420.40 217 362 6.3E-27 T 09-03-2017 TK78_RS30440 8978b8c225e544da664c22d5cb1ebca3 396 SUPERFAMILY SSF53067 83 389 1.19E-34 T 09-03-2017 TK78_RS30440 8978b8c225e544da664c22d5cb1ebca3 396 Pfam PF00480 ROK family 122 384 1.8E-30 T 09-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 TK78_RS30440 8978b8c225e544da664c22d5cb1ebca3 396 Gene3D G3DSA:1.10.10.10 8 74 3.6E-11 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS30440 8978b8c225e544da664c22d5cb1ebca3 396 SUPERFAMILY SSF46785 10 73 5.88E-11 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS16780 a358f2292cc4532a390f54d99fe90975 349 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 202 327 6.4E-19 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS16780 a358f2292cc4532a390f54d99fe90975 349 Gene3D G3DSA:1.10.540.10 1 108 1.3E-9 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS16780 a358f2292cc4532a390f54d99fe90975 349 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 30 107 2.0E-7 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS16780 a358f2292cc4532a390f54d99fe90975 349 SUPERFAMILY SSF56645 1 191 3.24E-17 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS16780 a358f2292cc4532a390f54d99fe90975 349 SUPERFAMILY SSF47203 200 328 2.74E-25 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS16780 a358f2292cc4532a390f54d99fe90975 349 Gene3D G3DSA:1.20.140.10 177 328 3.6E-27 T 09-03-2017 TK78_RS11890 5c3005bee69134856627cc933897d88d 299 SUPERFAMILY SSF46785 3 83 4.88E-18 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS11890 5c3005bee69134856627cc933897d88d 299 Gene3D G3DSA:3.40.190.10 182 265 3.1E-6 T 09-03-2017 TK78_RS11890 5c3005bee69134856627cc933897d88d 299 Pfam PF03466 LysR substrate binding domain 91 293 3.4E-24 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS11890 5c3005bee69134856627cc933897d88d 299 SUPERFAMILY SSF53850 91 296 3.15E-23 T 09-03-2017 TK78_RS11890 5c3005bee69134856627cc933897d88d 299 Gene3D G3DSA:3.40.190.10 92 181 7.5E-11 T 09-03-2017 TK78_RS11890 5c3005bee69134856627cc933897d88d 299 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 7 65 4.2E-17 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS11890 5c3005bee69134856627cc933897d88d 299 Gene3D G3DSA:1.10.10.10 5 88 9.0E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS11890 5c3005bee69134856627cc933897d88d 299 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 42 53 9.7E-5 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS11890 5c3005bee69134856627cc933897d88d 299 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 21 32 9.7E-5 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS11890 5c3005bee69134856627cc933897d88d 299 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 32 42 9.7E-5 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS27020 bf8c20c471f9700143571ee66a74f1da 269 Gene3D G3DSA:3.40.50.300 10 219 1.2E-24 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27020 bf8c20c471f9700143571ee66a74f1da 269 Pfam PF00005 ABC transporter 25 186 1.8E-11 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS27020 bf8c20c471f9700143571ee66a74f1da 269 SUPERFAMILY SSF52540 19 221 1.97E-22 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17670 5b73b5bb04b41814952d8b517a054e4d 182 Pfam PF10759 Protein of unknown function (DUF2587) 30 171 6.0E-80 T 09-03-2017 IPR019695 Bacterial proteasome activator GO:0061136 TK78_RS09060 1059ddfa13ef4c71361c4259371fb039 226 SUPERFAMILY SSF56784 23 200 6.14E-39 T 09-03-2017 IPR023214 HAD-like domain TK78_RS09060 1059ddfa13ef4c71361c4259371fb039 226 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 97 194 1.0E-18 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS09060 1059ddfa13ef4c71361c4259371fb039 226 Pfam PF13419 Haloacid dehalogenase-like hydrolase 26 196 3.3E-19 T 09-03-2017 IPR023214 HAD-like domain TK78_RS09060 1059ddfa13ef4c71361c4259371fb039 226 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 140 156 7.8E-5 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS09060 1059ddfa13ef4c71361c4259371fb039 226 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 185 198 7.8E-5 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS09060 1059ddfa13ef4c71361c4259371fb039 226 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 23 34 7.8E-5 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS09060 1059ddfa13ef4c71361c4259371fb039 226 Gene3D G3DSA:3.40.50.1000 81 200 5.7E-39 T 09-03-2017 IPR023214 HAD-like domain TK78_RS17225 cbcbb645b53a2cda9d69515f5dccccff 204 TIGRFAM TIGR00621 ssb: single-stranded DNA-binding protein 6 128 3.6E-29 T 09-03-2017 IPR011344 Single-stranded DNA-binding protein GO:0003697|GO:0006260 Reactome: R-HSA-2151201 TK78_RS17225 cbcbb645b53a2cda9d69515f5dccccff 204 Gene3D G3DSA:2.40.50.140 4 116 1.0E-40 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS17225 cbcbb645b53a2cda9d69515f5dccccff 204 Hamap MF_00984 Single-stranded DNA-binding protein. 4 113 30.023 T 09-03-2017 IPR011344 Single-stranded DNA-binding protein GO:0003697|GO:0006260 Reactome: R-HSA-2151201 TK78_RS17225 cbcbb645b53a2cda9d69515f5dccccff 204 SUPERFAMILY SSF50249 6 164 2.13E-43 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS17225 cbcbb645b53a2cda9d69515f5dccccff 204 Pfam PF00436 Single-strand binding protein family 7 106 2.0E-29 T 09-03-2017 IPR000424 Primosome PriB/single-strand DNA-binding GO:0003697 Reactome: R-HSA-2151201 TK78_RS20450 1e98d1ae570f2e10348dbd427ba83a9e 261 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 13 254 9.6E-66 T 09-03-2017 TK78_RS20450 1e98d1ae570f2e10348dbd427ba83a9e 261 Gene3D G3DSA:3.40.50.720 1 256 4.2E-83 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS20450 1e98d1ae570f2e10348dbd427ba83a9e 261 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 140 168 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS20450 1e98d1ae570f2e10348dbd427ba83a9e 261 SUPERFAMILY SSF51735 5 256 1.37E-80 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS20450 1e98d1ae570f2e10348dbd427ba83a9e 261 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 133 141 1.2E-11 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20450 1e98d1ae570f2e10348dbd427ba83a9e 261 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 153 172 1.2E-11 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20450 1e98d1ae570f2e10348dbd427ba83a9e 261 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 80 91 1.2E-11 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20450 1e98d1ae570f2e10348dbd427ba83a9e 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 1.5E-43 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20450 1e98d1ae570f2e10348dbd427ba83a9e 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 153 172 1.5E-43 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20450 1e98d1ae570f2e10348dbd427ba83a9e 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 174 191 1.5E-43 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20450 1e98d1ae570f2e10348dbd427ba83a9e 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 127 143 1.5E-43 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20450 1e98d1ae570f2e10348dbd427ba83a9e 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 80 91 1.5E-43 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20450 1e98d1ae570f2e10348dbd427ba83a9e 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 218 238 1.5E-43 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS22765 e6ff78e30bf98f1c66510bdbf04a526b 255 Pfam PF01925 Sulfite exporter TauE/SafE 10 249 2.5E-37 T 09-03-2017 IPR002781 Transmembrane protein TauE-like GO:0016021 TK78_RS16580 46770d4a0794b1b7cb15180721da05fe 97 SUPERFAMILY SSF54909 1 92 5.63E-16 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS16580 46770d4a0794b1b7cb15180721da05fe 97 Pfam PF07876 Stress responsive A/B Barrel Domain 2 96 8.9E-20 T 09-03-2017 IPR013097 Stress responsive alpha-beta barrel TK78_RS16580 46770d4a0794b1b7cb15180721da05fe 97 SMART SM00886 2 97 4.9E-20 T 09-03-2017 IPR013097 Stress responsive alpha-beta barrel TK78_RS16580 46770d4a0794b1b7cb15180721da05fe 97 Gene3D G3DSA:3.30.70.900 1 95 4.3E-23 T 09-03-2017 TK78_RS33845 2ccac67becdb85fb395496ef121cff30 276 SUPERFAMILY SSF51735 14 275 8.92E-75 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS33845 2ccac67becdb85fb395496ef121cff30 276 Gene3D G3DSA:3.40.50.720 11 275 3.5E-77 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS33845 2ccac67becdb85fb395496ef121cff30 276 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 160 188 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS33845 2ccac67becdb85fb395496ef121cff30 276 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 21 274 4.1E-57 T 09-03-2017 TK78_RS33845 2ccac67becdb85fb395496ef121cff30 276 TIGRFAM TIGR04316 dhbA_paeA: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase 17 275 1.6E-102 T 09-03-2017 IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase GO:0008667|GO:0019290|GO:0055114 MetaCyc: PWY-5901 TK78_RS33845 2ccac67becdb85fb395496ef121cff30 276 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 100 111 6.3E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33845 2ccac67becdb85fb395496ef121cff30 276 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 153 161 6.3E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33845 2ccac67becdb85fb395496ef121cff30 276 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 173 192 6.3E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33845 2ccac67becdb85fb395496ef121cff30 276 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 194 211 8.2E-41 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33845 2ccac67becdb85fb395496ef121cff30 276 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 173 192 8.2E-41 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33845 2ccac67becdb85fb395496ef121cff30 276 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 237 257 8.2E-41 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33845 2ccac67becdb85fb395496ef121cff30 276 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 100 111 8.2E-41 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33845 2ccac67becdb85fb395496ef121cff30 276 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 16 33 8.2E-41 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33845 2ccac67becdb85fb395496ef121cff30 276 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 147 163 8.2E-41 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS28195 c8b9307cc67f34896359ba0f56dfa66c 368 Gene3D G3DSA:3.40.640.10 15 237 6.0E-43 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS28195 c8b9307cc67f34896359ba0f56dfa66c 368 Gene3D G3DSA:3.90.1150.10 238 350 3.5E-16 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS28195 c8b9307cc67f34896359ba0f56dfa66c 368 PIRSF PIRSF000524 12 366 1.6E-66 T 09-03-2017 IPR024169 Serine-pyruvate aminotransferase/2-aminoethylphosphonate-pyruvate transaminase KEGG: 00440+2.6.1.37|MetaCyc: PWY-6832|Reactome: R-HSA-389661 TK78_RS28195 c8b9307cc67f34896359ba0f56dfa66c 368 Pfam PF00266 Aminotransferase class-V 17 262 1.2E-25 T 09-03-2017 IPR000192 Aminotransferase class V domain TK78_RS28195 c8b9307cc67f34896359ba0f56dfa66c 368 SUPERFAMILY SSF53383 15 348 2.48E-61 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS23765 e894c99924c9904280daf9a03c047fff 638 Pfam PF03704 Bacterial transcriptional activator domain 116 260 7.8E-39 T 09-03-2017 IPR005158 Bacterial transcriptional activator domain TK78_RS23765 e894c99924c9904280daf9a03c047fff 638 Gene3D G3DSA:1.10.10.10 27 95 3.9E-7 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS23765 e894c99924c9904280daf9a03c047fff 638 SMART SM00862 31 109 8.9E-11 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS23765 e894c99924c9904280daf9a03c047fff 638 SUPERFAMILY SSF48452 113 283 6.96E-34 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS23765 e894c99924c9904280daf9a03c047fff 638 SUPERFAMILY SSF46894 18 109 2.3E-13 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS23765 e894c99924c9904280daf9a03c047fff 638 Gene3D G3DSA:1.25.40.10 385 402 6.6E-6 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS23765 e894c99924c9904280daf9a03c047fff 638 Gene3D G3DSA:1.25.40.10 124 241 6.6E-6 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS23765 e894c99924c9904280daf9a03c047fff 638 SUPERFAMILY SSF52540 288 502 8.0E-20 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23765 e894c99924c9904280daf9a03c047fff 638 Gene3D G3DSA:3.40.50.300 308 355 6.3E-4 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23765 e894c99924c9904280daf9a03c047fff 638 SMART SM01043 116 261 5.7E-43 T 09-03-2017 IPR005158 Bacterial transcriptional activator domain TK78_RS23765 e894c99924c9904280daf9a03c047fff 638 Pfam PF00486 Transcriptional regulatory protein, C terminal 39 93 6.6E-7 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS23765 e894c99924c9904280daf9a03c047fff 638 PRINTS PR00364 Disease resistance protein signature 310 325 1.1E-8 T 09-03-2017 TK78_RS23765 e894c99924c9904280daf9a03c047fff 638 PRINTS PR00364 Disease resistance protein signature 401 415 1.1E-8 T 09-03-2017 TK78_RS23765 e894c99924c9904280daf9a03c047fff 638 PRINTS PR00364 Disease resistance protein signature 486 500 1.1E-8 T 09-03-2017 TK78_RS23765 e894c99924c9904280daf9a03c047fff 638 Pfam PF00931 NB-ARC domain 306 501 2.7E-10 T 09-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 TK78_RS09315 7d406089b2a8c610234b360dc7de0f8a 353 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 314 330 1.8E-18 T 09-03-2017 TK78_RS09315 7d406089b2a8c610234b360dc7de0f8a 353 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 138 153 1.8E-18 T 09-03-2017 TK78_RS09315 7d406089b2a8c610234b360dc7de0f8a 353 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 4 26 1.8E-18 T 09-03-2017 TK78_RS09315 7d406089b2a8c610234b360dc7de0f8a 353 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 262 277 1.8E-18 T 09-03-2017 TK78_RS09315 7d406089b2a8c610234b360dc7de0f8a 353 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 277 293 1.8E-18 T 09-03-2017 TK78_RS09315 7d406089b2a8c610234b360dc7de0f8a 353 SUPERFAMILY SSF51905 249 339 4.26E-54 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS09315 7d406089b2a8c610234b360dc7de0f8a 353 SUPERFAMILY SSF51905 6 159 4.26E-54 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS09315 7d406089b2a8c610234b360dc7de0f8a 353 Pfam PF01494 FAD binding domain 6 325 2.6E-27 T 09-03-2017 IPR002938 FAD-binding domain GO:0071949 TK78_RS09315 7d406089b2a8c610234b360dc7de0f8a 353 Gene3D G3DSA:3.50.50.60 7 164 4.3E-36 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS09315 7d406089b2a8c610234b360dc7de0f8a 353 Gene3D G3DSA:3.50.50.60 250 336 4.3E-36 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS34865 d6a6ac81f6eb13f5cc0d8d65b0b4e56e 151 ProDom PD020942 TRANSPOSASE C TN554 TRANSPOSON TRANSPOSITION FOR DNA-BINDING TRANSPOSABLE DNA ELEMENT 1 84 5.0E-6 T 09-03-2017 TK78_RS00010 d6a6ac81f6eb13f5cc0d8d65b0b4e56e 151 ProDom PD020942 TRANSPOSASE C TN554 TRANSPOSON TRANSPOSITION FOR DNA-BINDING TRANSPOSABLE DNA ELEMENT 1 84 5.0E-6 T 09-03-2017 TK78_RS12250 2d233c6b0324e6d270e20259039d81c1 321 Pfam PF00535 Glycosyl transferase family 2 5 124 2.6E-32 T 09-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 TK78_RS12250 2d233c6b0324e6d270e20259039d81c1 321 SUPERFAMILY SSF53448 2 230 3.66E-45 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS12250 2d233c6b0324e6d270e20259039d81c1 321 Gene3D G3DSA:3.90.550.10 2 201 3.0E-42 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS33720 b8480852cbbdab5f92a5b60c33311740 140 Pfam PF12802 MarR family 33 86 2.1E-9 T 09-03-2017 TK78_RS33720 b8480852cbbdab5f92a5b60c33311740 140 Gene3D G3DSA:1.10.10.10 30 92 3.7E-16 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS33720 b8480852cbbdab5f92a5b60c33311740 140 SMART SM00347 23 124 6.9E-10 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS33720 b8480852cbbdab5f92a5b60c33311740 140 Gene3D G3DSA:1.10.287.100 95 139 7.4E-16 T 09-03-2017 IPR013028 Transcription factor IIA, alpha subunit, N-terminal GO:0006367 TK78_RS33720 b8480852cbbdab5f92a5b60c33311740 140 SUPERFAMILY SSF46785 17 135 9.62E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS25370 f6c1408adcc63fc8bc6f58299a9a4d58 829 Pfam PF00801 PKD domain 510 576 2.3E-12 T 09-03-2017 IPR000601 PKD domain TK78_RS25370 f6c1408adcc63fc8bc6f58299a9a4d58 829 Gene3D G3DSA:2.60.40.670 506 587 6.1E-23 T 09-03-2017 IPR000601 PKD domain TK78_RS25370 f6c1408adcc63fc8bc6f58299a9a4d58 829 SMART SM00606 688 821 6.2E-41 T 09-03-2017 IPR006584 Cellulose binding, type IV GO:0030246 TK78_RS25370 f6c1408adcc63fc8bc6f58299a9a4d58 829 Pfam PF03422 Carbohydrate binding module (family 6) 696 820 2.4E-30 T 09-03-2017 IPR005084 Carbohydrate binding module family 6 GO:0030246 TK78_RS25370 f6c1408adcc63fc8bc6f58299a9a4d58 829 SMART SM00089 506 589 1.3E-20 T 09-03-2017 IPR022409 PKD/Chitinase domain TK78_RS25370 f6c1408adcc63fc8bc6f58299a9a4d58 829 SUPERFAMILY SSF49785 691 820 1.46E-28 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS25370 f6c1408adcc63fc8bc6f58299a9a4d58 829 SUPERFAMILY SSF49299 502 588 5.76E-23 T 09-03-2017 IPR000601 PKD domain TK78_RS25370 f6c1408adcc63fc8bc6f58299a9a4d58 829 SUPERFAMILY SSF50952 60 355 4.58E-22 T 09-03-2017 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 TK78_RS25370 f6c1408adcc63fc8bc6f58299a9a4d58 829 SUPERFAMILY SSF50952 407 487 4.58E-22 T 09-03-2017 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 TK78_RS25370 f6c1408adcc63fc8bc6f58299a9a4d58 829 Gene3D G3DSA:2.60.120.260 690 821 4.9E-38 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS25370 f6c1408adcc63fc8bc6f58299a9a4d58 829 Pfam PF07995 Glucose / Sorbosone dehydrogenase 67 342 1.1E-34 T 09-03-2017 IPR012938 Glucose/Sorbosone dehydrogenase GO:0005975|GO:0016901|GO:0048038 TK78_RS25370 f6c1408adcc63fc8bc6f58299a9a4d58 829 Gene3D G3DSA:2.120.10.30 49 505 1.3E-95 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS32390 17d8e79c0f9017d0423667c035b0079a 616 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 30 52 - T 09-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 TK78_RS32390 17d8e79c0f9017d0423667c035b0079a 616 Pfam PF00069 Protein kinase domain 25 269 6.8E-34 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS32390 17d8e79c0f9017d0423667c035b0079a 616 Gene3D G3DSA:1.10.510.10 107 328 2.3E-38 T 09-03-2017 TK78_RS32390 17d8e79c0f9017d0423667c035b0079a 616 Gene3D G3DSA:3.30.200.20 17 100 6.8E-13 T 09-03-2017 TK78_RS32390 17d8e79c0f9017d0423667c035b0079a 616 SUPERFAMILY SSF56112 21 334 1.27E-62 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS32390 17d8e79c0f9017d0423667c035b0079a 616 SMART SM00220 24 276 1.9E-39 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS32390 17d8e79c0f9017d0423667c035b0079a 616 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 142 154 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS12265 785dfca615a2d319ba4a9c5338c44ec3 353 Gene3D G3DSA:2.40.440.10 240 352 4.1E-15 T 09-03-2017 TK78_RS12265 785dfca615a2d319ba4a9c5338c44ec3 353 SUPERFAMILY SSF47090 144 213 1.19E-17 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS12265 785dfca615a2d319ba4a9c5338c44ec3 353 Pfam PF01471 Putative peptidoglycan binding domain 155 209 2.6E-14 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS12265 785dfca615a2d319ba4a9c5338c44ec3 353 Pfam PF03734 L,D-transpeptidase catalytic domain 240 351 1.9E-14 T 09-03-2017 IPR005490 L,D-transpeptidase catalytic domain GO:0016740 TK78_RS12265 785dfca615a2d319ba4a9c5338c44ec3 353 Gene3D G3DSA:1.10.101.10 143 210 2.1E-16 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS12265 785dfca615a2d319ba4a9c5338c44ec3 353 SUPERFAMILY SSF141523 238 352 2.49E-21 T 09-03-2017 TK78_RS06990 1220c2747a49b3c63f01376c90407510 331 SUPERFAMILY SSF55347 131 296 3.76E-36 T 09-03-2017 TK78_RS06990 1220c2747a49b3c63f01376c90407510 331 SUPERFAMILY SSF51735 4 156 6.9E-45 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS06990 1220c2747a49b3c63f01376c90407510 331 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 6 122 2.3E-23 T 09-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 TK78_RS06990 1220c2747a49b3c63f01376c90407510 331 Gene3D G3DSA:3.40.50.720 3 147 1.2E-43 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS06990 1220c2747a49b3c63f01376c90407510 331 Gene3D G3DSA:3.30.360.10 148 323 7.8E-35 T 09-03-2017 TK78_RS23805 baac7de4a19e508ea82dadc017f7594e 183 SUPERFAMILY SSF109854 3 175 1.1E-34 T 09-03-2017 TK78_RS23805 baac7de4a19e508ea82dadc017f7594e 183 Pfam PF04978 Protein of unknown function (DUF664) 23 176 2.5E-32 T 09-03-2017 IPR007061 Protein of unknown function DUF664 TK78_RS23805 baac7de4a19e508ea82dadc017f7594e 183 Gene3D G3DSA:1.20.120.450 5 180 5.8E-35 T 09-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase TK78_RS19680 687ec6dc8ecd64d12ba50de72ccd8d2d 376 Gene3D G3DSA:3.40.50.1820 110 374 2.6E-42 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS19680 687ec6dc8ecd64d12ba50de72ccd8d2d 376 Pfam PF00756 Putative esterase 136 368 8.6E-15 T 09-03-2017 IPR000801 Putative esterase Reactome: R-HSA-156590 TK78_RS19680 687ec6dc8ecd64d12ba50de72ccd8d2d 376 SUPERFAMILY SSF53474 115 374 8.04E-26 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS20275 96e3bab022d5f2635c5a43bc8b72183d 227 Pfam PF02441 Flavoprotein 9 157 2.6E-22 T 09-03-2017 IPR003382 Flavoprotein GO:0003824 Reactome: R-HSA-196783 TK78_RS20275 96e3bab022d5f2635c5a43bc8b72183d 227 Hamap MF_01984 Flavin prenyltransferase UbiX [ubiX]. 7 216 30.698 T 09-03-2017 IPR004507 Flavin prenyltransferase UbiX/Pad1 TK78_RS20275 96e3bab022d5f2635c5a43bc8b72183d 227 Gene3D G3DSA:3.40.50.1950 8 217 9.0E-65 T 09-03-2017 IPR003382 Flavoprotein GO:0003824 Reactome: R-HSA-196783 TK78_RS20275 96e3bab022d5f2635c5a43bc8b72183d 227 SUPERFAMILY SSF52507 91 216 3.79E-45 T 09-03-2017 IPR003382 Flavoprotein GO:0003824 Reactome: R-HSA-196783 TK78_RS20275 96e3bab022d5f2635c5a43bc8b72183d 227 SUPERFAMILY SSF52507 8 64 3.79E-45 T 09-03-2017 IPR003382 Flavoprotein GO:0003824 Reactome: R-HSA-196783 TK78_RS20275 96e3bab022d5f2635c5a43bc8b72183d 227 TIGRFAM TIGR00421 ubiX_pad: polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases 94 214 9.2E-36 T 09-03-2017 IPR004507 Flavin prenyltransferase UbiX/Pad1 TK78_RS08945 845cc0b7c26823f7b50c273ca867924b 320 SUPERFAMILY SSF161098 105 300 2.35E-27 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS08945 845cc0b7c26823f7b50c273ca867924b 320 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 140 319 9.3E-26 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS08945 845cc0b7c26823f7b50c273ca867924b 320 Gene3D G3DSA:1.10.3720.10 101 316 1.0E-26 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS08945 845cc0b7c26823f7b50c273ca867924b 320 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C 28 73 4.5E-13 T 09-03-2017 IPR025966 Oligopeptide transport permease C-like, N-terminal domain TK78_RS33315 5f9a623b56e290ecab61ed4561b2b3d7 674 SUPERFAMILY SSF56645 78 250 3.14E-30 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS33315 5f9a623b56e290ecab61ed4561b2b3d7 674 PIRSF PIRSF000168 5 608 4.6E-94 T 09-03-2017 IPR012258 Acyl-CoA oxidase GO:0003997|GO:0005777|GO:0006631|GO:0050660|GO:0055114 KEGG: 00071+1.3.3.6|KEGG: 00592+1.3.3.6|MetaCyc: PWY-5136|MetaCyc: PWY-6837|MetaCyc: PWY-6920|MetaCyc: PWY-7007|MetaCyc: PWY-7288|MetaCyc: PWY-7291|MetaCyc: PWY-7337|MetaCyc: PWY-7338|MetaCyc: PWY-7340|MetaCyc: PWY-735|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS33315 5f9a623b56e290ecab61ed4561b2b3d7 674 SUPERFAMILY SSF47203 271 431 1.42E-30 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS33315 5f9a623b56e290ecab61ed4561b2b3d7 674 Pfam PF08028 Acyl-CoA dehydrogenase, C-terminal domain 285 399 5.4E-6 T 09-03-2017 IPR013107 Acyl-CoA dehydrogenase, C-terminal domain TK78_RS33315 5f9a623b56e290ecab61ed4561b2b3d7 674 Gene3D G3DSA:2.40.110.10 131 250 4.7E-25 T 09-03-2017 TK78_RS33315 5f9a623b56e290ecab61ed4561b2b3d7 674 Gene3D G3DSA:1.20.140.10 282 432 2.3E-32 T 09-03-2017 TK78_RS33315 5f9a623b56e290ecab61ed4561b2b3d7 674 Gene3D G3DSA:1.20.140.10 456 577 3.6E-12 T 09-03-2017 TK78_RS33315 5f9a623b56e290ecab61ed4561b2b3d7 674 SUPERFAMILY SSF47203 445 584 3.51E-15 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS33315 5f9a623b56e290ecab61ed4561b2b3d7 674 Pfam PF01756 Acyl-CoA oxidase 478 582 6.9E-6 T 09-03-2017 IPR002655 Acyl-CoA oxidase, C-terminal GO:0003997|GO:0005777|GO:0006635|GO:0055114 KEGG: 00071+1.3.3.6|KEGG: 00592+1.3.3.6|MetaCyc: PWY-5136|MetaCyc: PWY-6837|MetaCyc: PWY-6920|MetaCyc: PWY-7007|MetaCyc: PWY-7288|MetaCyc: PWY-7291|MetaCyc: PWY-7337|MetaCyc: PWY-7338|MetaCyc: PWY-7340|MetaCyc: PWY-735|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS22165 77af37aef575cc2abfabf507d5390183 206 ProSitePatterns PS01081 TetR-type HTH domain signature. 42 73 - T 09-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site TK78_RS22165 77af37aef575cc2abfabf507d5390183 206 Pfam PF16859 Bacterial transcriptional repressor C-terminal 88 197 1.1E-27 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS22165 77af37aef575cc2abfabf507d5390183 206 Gene3D G3DSA:1.10.357.10 69 204 6.4E-37 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS22165 77af37aef575cc2abfabf507d5390183 206 SUPERFAMILY SSF46689 24 81 1.1E-11 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS22165 77af37aef575cc2abfabf507d5390183 206 Gene3D G3DSA:1.10.10.60 24 68 2.5E-19 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS22165 77af37aef575cc2abfabf507d5390183 206 SUPERFAMILY SSF48498 88 203 8.09E-24 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS22165 77af37aef575cc2abfabf507d5390183 206 Pfam PF00440 Bacterial regulatory proteins, tetR family 32 75 1.6E-10 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS17920 f1fd90a2fb9ab90c4a008f07d67675c5 355 TIGRFAM TIGR00233 trpS: tryptophan--tRNA ligase 33 352 1.0E-69 T 09-03-2017 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2 TK78_RS17920 f1fd90a2fb9ab90c4a008f07d67675c5 355 Gene3D G3DSA:3.40.50.620 33 230 1.9E-67 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS17920 f1fd90a2fb9ab90c4a008f07d67675c5 355 Gene3D G3DSA:1.10.240.10 231 321 1.5E-22 T 09-03-2017 TK78_RS17920 f1fd90a2fb9ab90c4a008f07d67675c5 355 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 41 50 - T 09-03-2017 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS17920 f1fd90a2fb9ab90c4a008f07d67675c5 355 SUPERFAMILY SSF52374 33 352 1.98E-71 T 09-03-2017 TK78_RS17920 f1fd90a2fb9ab90c4a008f07d67675c5 355 PRINTS PR01039 Tryptophanyl-tRNA synthetase signature 45 61 1.4E-25 T 09-03-2017 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2 TK78_RS17920 f1fd90a2fb9ab90c4a008f07d67675c5 355 PRINTS PR01039 Tryptophanyl-tRNA synthetase signature 173 194 1.4E-25 T 09-03-2017 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2 TK78_RS17920 f1fd90a2fb9ab90c4a008f07d67675c5 355 PRINTS PR01039 Tryptophanyl-tRNA synthetase signature 223 233 1.4E-25 T 09-03-2017 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2 TK78_RS17920 f1fd90a2fb9ab90c4a008f07d67675c5 355 PRINTS PR01039 Tryptophanyl-tRNA synthetase signature 96 115 1.4E-25 T 09-03-2017 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2 TK78_RS17920 f1fd90a2fb9ab90c4a008f07d67675c5 355 Pfam PF00579 tRNA synthetases class I (W and Y) 32 308 1.5E-51 T 09-03-2017 IPR002305 Aminoacyl-tRNA synthetase, class Ic GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS34330 47d1ce58f8a27d96c804ac227ca20b74 234 Pfam PF12697 Alpha/beta hydrolase family 4 224 8.5E-12 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS34330 47d1ce58f8a27d96c804ac227ca20b74 234 Gene3D G3DSA:3.40.50.1820 4 229 2.0E-34 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS34330 47d1ce58f8a27d96c804ac227ca20b74 234 SUPERFAMILY SSF53474 5 228 2.2E-22 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS11300 2239b5cf379c6c064ca3d9b3dbe93f71 372 PRINTS PR00721 Stomatin signature 174 195 3.2E-32 T 09-03-2017 IPR001972 Stomatin family GO:0016020 TK78_RS11300 2239b5cf379c6c064ca3d9b3dbe93f71 372 PRINTS PR00721 Stomatin signature 111 128 3.2E-32 T 09-03-2017 IPR001972 Stomatin family GO:0016020 TK78_RS11300 2239b5cf379c6c064ca3d9b3dbe93f71 372 PRINTS PR00721 Stomatin signature 131 154 3.2E-32 T 09-03-2017 IPR001972 Stomatin family GO:0016020 TK78_RS11300 2239b5cf379c6c064ca3d9b3dbe93f71 372 PRINTS PR00721 Stomatin signature 76 97 3.2E-32 T 09-03-2017 IPR001972 Stomatin family GO:0016020 TK78_RS11300 2239b5cf379c6c064ca3d9b3dbe93f71 372 PRINTS PR00721 Stomatin signature 155 173 3.2E-32 T 09-03-2017 IPR001972 Stomatin family GO:0016020 TK78_RS11300 2239b5cf379c6c064ca3d9b3dbe93f71 372 PRINTS PR00721 Stomatin signature 28 50 3.2E-32 T 09-03-2017 IPR001972 Stomatin family GO:0016020 TK78_RS11300 2239b5cf379c6c064ca3d9b3dbe93f71 372 SUPERFAMILY SSF117892 52 186 2.88E-39 T 09-03-2017 IPR001107 Band 7 domain TK78_RS11300 2239b5cf379c6c064ca3d9b3dbe93f71 372 ProSitePatterns PS01270 Band 7 protein family signature. 135 163 - T 09-03-2017 IPR018080 Band 7/stomatin-like, conserved site TK78_RS11300 2239b5cf379c6c064ca3d9b3dbe93f71 372 SMART SM00244 21 179 4.9E-51 T 09-03-2017 IPR001107 Band 7 domain TK78_RS11300 2239b5cf379c6c064ca3d9b3dbe93f71 372 Pfam PF01145 SPFH domain / Band 7 family 25 195 4.4E-36 T 09-03-2017 IPR001107 Band 7 domain TK78_RS07460 83990c466c2bf6ad5d50df084b6ffc84 215 SUPERFAMILY SSF161098 10 197 8.24E-36 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS07460 83990c466c2bf6ad5d50df084b6ffc84 215 TIGRFAM TIGR01726 HEQRo_perm_3TM: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family 7 106 9.8E-20 T 09-03-2017 IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain GO:0005215|GO:0006810|GO:0016021 TK78_RS07460 83990c466c2bf6ad5d50df084b6ffc84 215 Gene3D G3DSA:1.10.3720.10 5 212 4.0E-39 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS07460 83990c466c2bf6ad5d50df084b6ffc84 215 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 30 212 2.0E-12 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS09320 2c5980b57298b93dc510c5bbfc35fd15 196 Gene3D G3DSA:1.10.357.10 4 189 5.4E-30 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS09320 2c5980b57298b93dc510c5bbfc35fd15 196 Pfam PF00440 Bacterial regulatory proteins, tetR family 10 55 1.0E-4 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS09320 2c5980b57298b93dc510c5bbfc35fd15 196 SUPERFAMILY SSF46689 3 71 3.23E-13 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS01790 56e98374c0d27a913fe838cc86ff02c5 1068 Pfam PF05592 Bacterial alpha-L-rhamnosidase 529 1031 1.7E-189 T 09-03-2017 IPR008902 Bacterial alpha-L-rhamnosidase TK78_RS01790 56e98374c0d27a913fe838cc86ff02c5 1068 SUPERFAMILY SSF48208 638 1033 1.16E-42 T 09-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 TK78_RS01790 56e98374c0d27a913fe838cc86ff02c5 1068 Gene3D G3DSA:2.60.120.260 519 632 1.9E-17 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS01790 56e98374c0d27a913fe838cc86ff02c5 1068 SUPERFAMILY SSF49785 179 267 3.4E-6 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS01790 56e98374c0d27a913fe838cc86ff02c5 1068 Gene3D G3DSA:2.60.120.260 180 268 6.6E-4 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS01790 56e98374c0d27a913fe838cc86ff02c5 1068 Pfam PF08531 Alpha-L-rhamnosidase N-terminal domain 351 520 2.2E-58 T 09-03-2017 IPR013737 Bacterial alpha-L-rhamnosidase N-terminal TK78_RS01790 56e98374c0d27a913fe838cc86ff02c5 1068 Gene3D G3DSA:2.60.40.10 72 147 7.2E-6 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS01790 56e98374c0d27a913fe838cc86ff02c5 1068 SUPERFAMILY SSF49785 292 413 6.24E-5 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS24360 2f016e28c93c5e58f2bc37ffd62048f4 277 SMART SM01232 122 214 3.2E-36 T 09-03-2017 IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding GO:0003684|GO:0003906|GO:0006289|GO:0008270|GO:0016799 TK78_RS24360 2f016e28c93c5e58f2bc37ffd62048f4 277 SUPERFAMILY SSF57716 219 268 2.85E-13 T 09-03-2017 TK78_RS24360 2f016e28c93c5e58f2bc37ffd62048f4 277 SMART SM00898 2 108 5.6E-23 T 09-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 TK78_RS24360 2f016e28c93c5e58f2bc37ffd62048f4 277 Gene3D G3DSA:1.10.8.50 123 268 7.7E-45 T 09-03-2017 TK78_RS24360 2f016e28c93c5e58f2bc37ffd62048f4 277 ProSitePatterns PS01242 Zinc finger FPG-type signature. 243 267 - T 09-03-2017 IPR015887 DNA glycosylase/AP lyase, zinc finger domain, DNA-binding site GO:0003677|GO:0003906|GO:0006281|GO:0008270|GO:0016799 TK78_RS24360 2f016e28c93c5e58f2bc37ffd62048f4 277 Pfam PF06831 Formamidopyrimidine-DNA glycosylase H2TH domain 122 205 5.7E-22 T 09-03-2017 IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding GO:0003684|GO:0003906|GO:0006289|GO:0008270|GO:0016799 TK78_RS24360 2f016e28c93c5e58f2bc37ffd62048f4 277 Gene3D G3DSA:3.20.190.10 2 122 5.0E-15 T 09-03-2017 TK78_RS24360 2f016e28c93c5e58f2bc37ffd62048f4 277 SUPERFAMILY SSF81624 2 123 3.53E-24 T 09-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 TK78_RS24360 2f016e28c93c5e58f2bc37ffd62048f4 277 SUPERFAMILY SSF46946 121 205 1.01E-25 T 09-03-2017 IPR010979 Ribosomal protein S13-like, H2TH GO:0003676 TK78_RS24360 2f016e28c93c5e58f2bc37ffd62048f4 277 Pfam PF01149 Formamidopyrimidine-DNA glycosylase N-terminal domain 2 102 5.1E-8 T 09-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 TK78_RS24360 2f016e28c93c5e58f2bc37ffd62048f4 277 Pfam PF06827 Zinc finger found in FPG and IleRS 242 268 5.9E-7 T 09-03-2017 IPR010663 Zinc finger, FPG/IleRS-type Reactome: R-HSA-379726 TK78_RS13865 0a1c2c0fde9e7f2c670b6690370df328 62 Pfam PF04149 Domain of unknown function (DUF397) 11 58 2.1E-15 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS33400 de28b84027ca3a7b239d6ca90a42288e 396 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 198 390 4.7E-37 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS33400 de28b84027ca3a7b239d6ca90a42288e 396 SMART SM00331 167 390 8.9E-31 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS33400 de28b84027ca3a7b239d6ca90a42288e 396 SUPERFAMILY SSF81606 175 387 2.14E-7 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS04425 d1bdd5494332f443e47378c359017ad7 288 SUPERFAMILY SSF47413 14 70 1.83E-8 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS04425 d1bdd5494332f443e47378c359017ad7 288 SMART SM00530 18 73 6.0E-8 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS04425 d1bdd5494332f443e47378c359017ad7 288 Gene3D G3DSA:1.10.260.40 18 71 1.9E-8 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS04425 d1bdd5494332f443e47378c359017ad7 288 Pfam PF13560 Helix-turn-helix domain 15 74 3.3E-12 T 09-03-2017 TK78_RS16295 63995b5e5b34634998032e1b2c5ca0a5 324 Gene3D G3DSA:3.60.10.10 111 268 1.1E-8 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS16295 63995b5e5b34634998032e1b2c5ca0a5 324 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 115 315 7.5E-19 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS16295 63995b5e5b34634998032e1b2c5ca0a5 324 SUPERFAMILY SSF56219 109 322 2.75E-26 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS02035 0f28f91d8fa18a89bc746e1d49257657 417 SUPERFAMILY SSF52540 107 317 3.25E-17 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS02035 0f28f91d8fa18a89bc746e1d49257657 417 Pfam PF07728 AAA domain (dynein-related subfamily) 128 270 1.5E-35 T 09-03-2017 IPR011704 ATPase, dynein-related, AAA domain GO:0005524|GO:0016887 TK78_RS02035 0f28f91d8fa18a89bc746e1d49257657 417 Gene3D G3DSA:3.40.50.300 109 278 7.0E-21 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18865 9a58a826e200f71d96bfe1f7501d5c34 120 Pfam PF02635 DsrE/DsrF-like family 3 108 2.7E-10 T 09-03-2017 IPR003787 Sulphur relay, DsrE/F-like protein TK78_RS18865 9a58a826e200f71d96bfe1f7501d5c34 120 Gene3D G3DSA:3.40.1260.10 3 112 4.3E-16 T 09-03-2017 IPR027396 DsrEFH-like TK78_RS18865 9a58a826e200f71d96bfe1f7501d5c34 120 SUPERFAMILY SSF75169 3 112 1.85E-18 T 09-03-2017 IPR027396 DsrEFH-like TK78_RS33335 d3eacbd14a3671aee5477432047a1724 361 Gene3D G3DSA:1.10.3470.10 30 359 1.7E-105 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS33335 d3eacbd14a3671aee5477432047a1724 361 Pfam PF01032 FecCD transport family 39 356 7.2E-93 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS33335 d3eacbd14a3671aee5477432047a1724 361 SUPERFAMILY SSF81345 29 356 1.96E-79 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS13700 d9b2ca577dff4fb6be5e4826d7712284 175 Gene3D G3DSA:3.40.630.30 3 173 9.7E-34 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS13700 d9b2ca577dff4fb6be5e4826d7712284 175 SUPERFAMILY SSF55729 13 156 5.41E-28 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS13700 d9b2ca577dff4fb6be5e4826d7712284 175 Pfam PF13302 Acetyltransferase (GNAT) domain 16 155 2.4E-22 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS00970 0e2f51cbfcd3ecf22e9dbd1917774b08 197 Pfam PF03029 Conserved hypothetical ATP binding protein 57 184 5.7E-16 T 09-03-2017 IPR004130 GPN-loop GTPase TK78_RS00970 0e2f51cbfcd3ecf22e9dbd1917774b08 197 SUPERFAMILY SSF52540 9 183 8.01E-20 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS00970 0e2f51cbfcd3ecf22e9dbd1917774b08 197 Gene3D G3DSA:3.40.50.300 9 181 1.9E-14 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS26120 82fb310ab129ec18fb1b7ffefdf9d7a9 210 Pfam PF00440 Bacterial regulatory proteins, tetR family 20 63 1.2E-13 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS26120 82fb310ab129ec18fb1b7ffefdf9d7a9 210 Pfam PF16859 Bacterial transcriptional repressor C-terminal 90 201 9.3E-28 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS26120 82fb310ab129ec18fb1b7ffefdf9d7a9 210 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 41 64 4.1E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS26120 82fb310ab129ec18fb1b7ffefdf9d7a9 210 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 20 33 4.1E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS26120 82fb310ab129ec18fb1b7ffefdf9d7a9 210 Gene3D G3DSA:1.10.357.10 59 209 2.2E-48 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS26120 82fb310ab129ec18fb1b7ffefdf9d7a9 210 SUPERFAMILY SSF46689 11 74 1.7E-16 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS26120 82fb310ab129ec18fb1b7ffefdf9d7a9 210 SUPERFAMILY SSF48498 91 209 4.15E-26 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS26120 82fb310ab129ec18fb1b7ffefdf9d7a9 210 Gene3D G3DSA:1.10.10.60 11 58 3.1E-23 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS27300 e8b216762f53124802094773d3a4a197 195 Gene3D G3DSA:1.10.10.10 11 85 5.3E-14 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS27300 e8b216762f53124802094773d3a4a197 195 Pfam PF12840 Helix-turn-helix domain 14 67 2.8E-13 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS27300 e8b216762f53124802094773d3a4a197 195 SUPERFAMILY SSF46785 10 139 7.11E-18 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS27300 e8b216762f53124802094773d3a4a197 195 SMART SM00418 13 94 1.4E-5 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS05500 a5dda18fbdaa05e716e1ad830226394a 370 TIGRFAM TIGR01728 SsuA_fam: ABC transporter, substrate-binding protein, aliphatic sulfonates family 55 348 8.6E-60 T 09-03-2017 IPR010067 Aliphatic sulfonates-binding protein GO:0006790|GO:0006810|GO:0016020 TK78_RS05500 a5dda18fbdaa05e716e1ad830226394a 370 SUPERFAMILY SSF53850 52 285 5.59E-40 T 09-03-2017 TK78_RS05500 a5dda18fbdaa05e716e1ad830226394a 370 Gene3D G3DSA:3.40.190.10 54 150 5.2E-5 T 09-03-2017 TK78_RS05500 a5dda18fbdaa05e716e1ad830226394a 370 Gene3D G3DSA:3.40.190.10 151 270 5.0E-19 T 09-03-2017 TK78_RS05500 a5dda18fbdaa05e716e1ad830226394a 370 Pfam PF13379 NMT1-like family 52 289 2.4E-28 T 09-03-2017 TK78_RS27085 d00d216d595be2b81e95d2fa2437956d 356 Pfam PF00953 Glycosyl transferase family 4 82 275 3.3E-37 T 09-03-2017 IPR000715 Glycosyl transferase, family 4 GO:0008963|GO:0016021 KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471|Reactome: R-HSA-446193|Reactome: R-HSA-4549356 TK78_RS27085 d00d216d595be2b81e95d2fa2437956d 356 Pfam PF10555 Phospho-N-acetylmuramoyl-pentapeptide-transferase signature 1 46 58 2.8E-5 T 09-03-2017 IPR018480 Phospho-N-acetylmuramoyl-pentapeptide transferase, conserved site KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TK78_RS27085 d00d216d595be2b81e95d2fa2437956d 356 ProSitePatterns PS01348 MraY family signature 2. 174 185 - T 09-03-2017 IPR018480 Phospho-N-acetylmuramoyl-pentapeptide transferase, conserved site KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TK78_RS27085 d00d216d595be2b81e95d2fa2437956d 356 Hamap MF_00038 Phospho-N-acetylmuramoyl-pentapeptide-transferase [mraY]. 3 349 24.174 T 09-03-2017 IPR003524 Phospho-N-acetylmuramoyl-pentapeptide transferase GO:0008963|GO:0016020 KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TK78_RS27085 d00d216d595be2b81e95d2fa2437956d 356 TIGRFAM TIGR00445 mraY: phospho-N-acetylmuramoyl-pentapeptide-transferase 19 345 6.9E-101 T 09-03-2017 IPR003524 Phospho-N-acetylmuramoyl-pentapeptide transferase GO:0008963|GO:0016020 KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TK78_RS27085 d00d216d595be2b81e95d2fa2437956d 356 ProSitePatterns PS01347 MraY family signature 1. 46 58 - T 09-03-2017 IPR018480 Phospho-N-acetylmuramoyl-pentapeptide transferase, conserved site KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TK78_RS13175 a9e0c2d691a7fc569d17fda2574a5bf0 152 Gene3D G3DSA:3.40.630.30 7 138 8.0E-26 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS13175 a9e0c2d691a7fc569d17fda2574a5bf0 152 SUPERFAMILY SSF55729 7 139 5.67E-25 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS13175 a9e0c2d691a7fc569d17fda2574a5bf0 152 Pfam PF00583 Acetyltransferase (GNAT) family 63 135 1.3E-10 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS07940 e9fbfbefccc4258dae8fafba3c45c0ab 313 SUPERFAMILY SSF161098 28 307 1.02E-49 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS07940 e9fbfbefccc4258dae8fafba3c45c0ab 313 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 107 302 2.7E-9 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS07940 e9fbfbefccc4258dae8fafba3c45c0ab 313 Gene3D G3DSA:1.10.3720.10 24 304 2.6E-50 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS06515 7b0e61e1751765dfc9d8cd6ea7e40f14 164 PRINTS PR00598 Bacterial regulatory protein MarR family signature 140 160 1.1E-9 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS06515 7b0e61e1751765dfc9d8cd6ea7e40f14 164 PRINTS PR00598 Bacterial regulatory protein MarR family signature 74 90 1.1E-9 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS06515 7b0e61e1751765dfc9d8cd6ea7e40f14 164 PRINTS PR00598 Bacterial regulatory protein MarR family signature 91 106 1.1E-9 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS06515 7b0e61e1751765dfc9d8cd6ea7e40f14 164 PRINTS PR00598 Bacterial regulatory protein MarR family signature 110 126 1.1E-9 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS06515 7b0e61e1751765dfc9d8cd6ea7e40f14 164 Gene3D G3DSA:1.10.10.10 36 162 1.7E-30 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS06515 7b0e61e1751765dfc9d8cd6ea7e40f14 164 SUPERFAMILY SSF46785 35 163 1.66E-28 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS06515 7b0e61e1751765dfc9d8cd6ea7e40f14 164 Pfam PF01047 MarR family 57 114 1.4E-14 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS06515 7b0e61e1751765dfc9d8cd6ea7e40f14 164 SMART SM00347 50 150 8.6E-23 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS26170 8688f4d625136190ebce5f77e7ac75c2 285 PRINTS PR00599 Methionine aminopeptidase-1 signature 126 142 2.9E-21 T 09-03-2017 IPR001714 Peptidase M24, methionine aminopeptidase TK78_RS26170 8688f4d625136190ebce5f77e7ac75c2 285 PRINTS PR00599 Methionine aminopeptidase-1 signature 104 117 2.9E-21 T 09-03-2017 IPR001714 Peptidase M24, methionine aminopeptidase TK78_RS26170 8688f4d625136190ebce5f77e7ac75c2 285 PRINTS PR00599 Methionine aminopeptidase-1 signature 227 239 2.9E-21 T 09-03-2017 IPR001714 Peptidase M24, methionine aminopeptidase TK78_RS26170 8688f4d625136190ebce5f77e7ac75c2 285 PRINTS PR00599 Methionine aminopeptidase-1 signature 196 208 2.9E-21 T 09-03-2017 IPR001714 Peptidase M24, methionine aminopeptidase TK78_RS26170 8688f4d625136190ebce5f77e7ac75c2 285 Hamap MF_01974 Methionine aminopeptidase [map]. 39 285 40.466 T 09-03-2017 IPR002467 Peptidase M24A, methionine aminopeptidase, subfamily 1 GO:0004177|GO:0006508|GO:0008235 TK78_RS26170 8688f4d625136190ebce5f77e7ac75c2 285 ProSitePatterns PS00680 Methionine aminopeptidase subfamily 1 signature. 202 220 - T 09-03-2017 IPR002467 Peptidase M24A, methionine aminopeptidase, subfamily 1 GO:0004177|GO:0006508|GO:0008235 TK78_RS26170 8688f4d625136190ebce5f77e7ac75c2 285 Pfam PF00557 Metallopeptidase family M24 48 276 9.5E-54 T 09-03-2017 IPR000994 Peptidase M24, structural domain TK78_RS26170 8688f4d625136190ebce5f77e7ac75c2 285 Gene3D G3DSA:3.90.230.10 41 284 9.0E-98 T 09-03-2017 IPR000994 Peptidase M24, structural domain TK78_RS26170 8688f4d625136190ebce5f77e7ac75c2 285 SUPERFAMILY SSF55920 7 284 6.8E-88 T 09-03-2017 IPR000994 Peptidase M24, structural domain TK78_RS26170 8688f4d625136190ebce5f77e7ac75c2 285 TIGRFAM TIGR00500 met_pdase_I: methionine aminopeptidase, type I 41 283 4.3E-92 T 09-03-2017 IPR002467 Peptidase M24A, methionine aminopeptidase, subfamily 1 GO:0004177|GO:0006508|GO:0008235 TK78_RS07935 265dfb7b53e0f43c872e315a3a66ac8b 267 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 84 257 2.2E-16 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS07935 265dfb7b53e0f43c872e315a3a66ac8b 267 Gene3D G3DSA:1.10.3720.10 10 264 2.8E-50 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS07935 265dfb7b53e0f43c872e315a3a66ac8b 267 SUPERFAMILY SSF161098 5 257 1.21E-49 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS21585 c57d09ef4c403ba8e23f229156493522 180 Pfam PF04417 Protein of unknown function (DUF501) 36 154 2.2E-35 T 09-03-2017 IPR007511 Protein of unknown function DUF501 TK78_RS28490 7f9d928676470998ac380c6b309f875d 83 Pfam PF03777 Small secreted domain (DUF320) 28 82 1.8E-23 T 09-03-2017 IPR005528 Domain of unknown function DUF320, Streptomyces species TK78_RS21145 14d989be16f54c83e728765c04c288d2 545 Pfam PF00905 Penicillin binding protein transpeptidase domain 267 542 7.1E-34 T 09-03-2017 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 TK78_RS21145 14d989be16f54c83e728765c04c288d2 545 Gene3D G3DSA:3.40.710.10 247 543 3.3E-48 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS21145 14d989be16f54c83e728765c04c288d2 545 SUPERFAMILY SSF56601 241 543 3.48E-53 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS27850 7c3314b6651fe3f24d6071105597af18 722 TIGRFAM TIGR00194 uvrC: excinuclease ABC subunit C 11 466 3.6E-131 T 09-03-2017 IPR004791 UvrABC system, subunit C GO:0005737|GO:0006281|GO:0009380|GO:0009381 TK78_RS27850 7c3314b6651fe3f24d6071105597af18 722 Pfam PF08459 UvrC Helix-hairpin-helix N-terminal 393 630 3.5E-52 T 09-03-2017 IPR001162 UvrC family homology region TK78_RS27850 7c3314b6651fe3f24d6071105597af18 722 SMART SM00465 17 99 1.2E-20 T 09-03-2017 IPR000305 GIY-YIG nuclease superfamily TK78_RS27850 7c3314b6651fe3f24d6071105597af18 722 SUPERFAMILY SSF47781 588 698 1.21E-24 T 09-03-2017 IPR010994 RuvA domain 2-like TK78_RS27850 7c3314b6651fe3f24d6071105597af18 722 Gene3D G3DSA:4.10.860.10 187 246 6.3E-17 T 09-03-2017 IPR001943 UVR domain GO:0005515 TK78_RS27850 7c3314b6651fe3f24d6071105597af18 722 Gene3D G3DSA:3.40.1440.10 18 95 8.5E-11 T 09-03-2017 IPR027299 GIY-YIG domain TK78_RS27850 7c3314b6651fe3f24d6071105597af18 722 Gene3D G3DSA:1.10.150.20 644 696 3.1E-21 T 09-03-2017 TK78_RS27850 7c3314b6651fe3f24d6071105597af18 722 Pfam PF14520 Helix-hairpin-helix domain 646 696 1.1E-9 T 09-03-2017 TK78_RS27850 7c3314b6651fe3f24d6071105597af18 722 Pfam PF02151 UvrB/uvrC motif 210 242 1.7E-7 T 09-03-2017 IPR001943 UVR domain GO:0005515 TK78_RS27850 7c3314b6651fe3f24d6071105597af18 722 SUPERFAMILY SSF46600 194 246 2.09E-12 T 09-03-2017 IPR001943 UVR domain GO:0005515 TK78_RS27850 7c3314b6651fe3f24d6071105597af18 722 Pfam PF01541 GIY-YIG catalytic domain 19 92 1.1E-10 T 09-03-2017 IPR000305 GIY-YIG nuclease superfamily TK78_RS27850 7c3314b6651fe3f24d6071105597af18 722 SMART SM00278 676 695 0.11 T 09-03-2017 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 TK78_RS27850 7c3314b6651fe3f24d6071105597af18 722 SMART SM00278 644 663 99.0 T 09-03-2017 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 TK78_RS27850 7c3314b6651fe3f24d6071105597af18 722 SUPERFAMILY SSF82771 17 101 1.31E-23 T 09-03-2017 IPR000305 GIY-YIG nuclease superfamily TK78_RS27850 7c3314b6651fe3f24d6071105597af18 722 Hamap MF_00203 UvrABC system protein C [uvrC]. 4 695 30.376 T 09-03-2017 IPR004791 UvrABC system, subunit C GO:0005737|GO:0006281|GO:0009380|GO:0009381 TK78_RS00220 46d615d995e902ac2610006b0cde9713 186 Pfam PF00440 Bacterial regulatory proteins, tetR family 14 57 1.3E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS00220 46d615d995e902ac2610006b0cde9713 186 SUPERFAMILY SSF46689 5 75 2.69E-13 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS00220 46d615d995e902ac2610006b0cde9713 186 SUPERFAMILY SSF48498 75 181 1.34E-5 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS00220 46d615d995e902ac2610006b0cde9713 186 Gene3D G3DSA:1.10.357.10 5 177 1.0E-25 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS15645 56628a26226763f34beaed087f0c5a95 126 SUPERFAMILY SSF54427 1 125 4.69E-25 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS15645 56628a26226763f34beaed087f0c5a95 126 Gene3D G3DSA:3.10.450.50 1 111 2.6E-17 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS15645 56628a26226763f34beaed087f0c5a95 126 Pfam PF12680 SnoaL-like domain 1 103 1.2E-15 T 09-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain TK78_RS05350 a38053e84d0d64d781421325ad6aab23 387 SUPERFAMILY SSF52540 117 350 3.01E-41 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS05350 a38053e84d0d64d781421325ad6aab23 387 Hamap MF_01820 Putative ribosome biogenesis GTPase RsgA [rsgA]. 41 353 27.297 T 09-03-2017 IPR004881 Ribosome biogenesis GTPase RsgA, putative GO:0003924|GO:0005525 TK78_RS05350 a38053e84d0d64d781421325ad6aab23 387 Gene3D G3DSA:3.40.50.300 117 287 3.4E-34 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS05350 a38053e84d0d64d781421325ad6aab23 387 Pfam PF03193 Protein of unknown function, DUF258 168 289 9.2E-31 T 09-03-2017 IPR010914 RsgA type GTPase domain GO:0003924|GO:0005525 TK78_RS05350 a38053e84d0d64d781421325ad6aab23 387 Gene3D G3DSA:1.10.40.50 293 356 1.1E-21 T 09-03-2017 TK78_RS05350 a38053e84d0d64d781421325ad6aab23 387 TIGRFAM TIGR00157 TIGR00157: ribosome small subunit-dependent GTPase A 81 346 2.7E-38 T 09-03-2017 IPR004881 Ribosome biogenesis GTPase RsgA, putative GO:0003924|GO:0005525 TK78_RS28425 4561021ecd89f34b80f709d73a1d0bfc 255 SUPERFAMILY SSF51735 6 253 1.35E-50 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS28425 4561021ecd89f34b80f709d73a1d0bfc 255 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 14 251 3.4E-66 T 09-03-2017 TK78_RS28425 4561021ecd89f34b80f709d73a1d0bfc 255 PIRSF PIRSF000094 2 255 4.7E-86 T 09-03-2017 IPR014358 Enoyl-[acyl-carrier-protein] reductase (NADH) GO:0004318|GO:0006633|GO:0055114 KEGG: 00061+1.3.1.9|MetaCyc: PWY-5971|MetaCyc: PWY-5973|MetaCyc: PWY-5989|MetaCyc: PWY-6113|MetaCyc: PWY-6282|MetaCyc: PWY-6519|MetaCyc: PWY-7663|MetaCyc: PWY-7664|MetaCyc: PWYG-321 TK78_RS28425 4561021ecd89f34b80f709d73a1d0bfc 255 Gene3D G3DSA:3.40.50.720 3 254 1.4E-56 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS21395 570e0f3c8b6ae7bab469bf9c621f12a9 850 Pfam PF14440 Xanthomonas XOO_2897-like deaminase 532 630 7.0E-32 T 09-03-2017 IPR032722 Deaminase, Xanthomonas XOO_2897-like TK78_RS21395 570e0f3c8b6ae7bab469bf9c621f12a9 850 Pfam PF14435 SUKH-4 immunity protein 668 844 1.4E-42 T 09-03-2017 IPR025851 SUKH-4 immunity protein TK78_RS07395 b89455c80cad21ce887f1614c8631050 481 SUPERFAMILY SSF55486 232 468 4.83E-54 T 09-03-2017 TK78_RS07395 b89455c80cad21ce887f1614c8631050 481 SUPERFAMILY SSF63737 34 223 4.58E-30 T 09-03-2017 TK78_RS07395 b89455c80cad21ce887f1614c8631050 481 Pfam PF01433 Peptidase family M1 50 372 5.8E-34 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS07395 b89455c80cad21ce887f1614c8631050 481 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 334 346 1.5E-10 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS07395 b89455c80cad21ce887f1614c8631050 481 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 160 175 1.5E-10 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS07395 b89455c80cad21ce887f1614c8631050 481 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 315 330 1.5E-10 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS07395 b89455c80cad21ce887f1614c8631050 481 Gene3D G3DSA:1.10.390.10 329 469 4.1E-19 T 09-03-2017 TK78_RS31495 e237dc8a3b62531e314597c64ece60ef 86 ProSitePatterns PS00622 LuxR-type HTH domain signature. 37 64 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS31495 e237dc8a3b62531e314597c64ece60ef 86 SMART SM00421 20 77 2.7E-19 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS31495 e237dc8a3b62531e314597c64ece60ef 86 Gene3D G3DSA:1.10.10.10 2 81 2.7E-25 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS31495 e237dc8a3b62531e314597c64ece60ef 86 Pfam PF00196 Bacterial regulatory proteins, luxR family 22 76 5.8E-17 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS31495 e237dc8a3b62531e314597c64ece60ef 86 SUPERFAMILY SSF46894 12 83 4.42E-20 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS31495 e237dc8a3b62531e314597c64ece60ef 86 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 37 53 2.7E-12 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS31495 e237dc8a3b62531e314597c64ece60ef 86 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 23 37 2.7E-12 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS31495 e237dc8a3b62531e314597c64ece60ef 86 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 53 65 2.7E-12 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS25480 1d55946bcbf1e0e154a1edc061fe5716 237 SUPERFAMILY SSF109854 7 115 4.88E-11 T 09-03-2017 TK78_RS25480 1d55946bcbf1e0e154a1edc061fe5716 237 SUPERFAMILY SSF109854 123 231 6.41E-6 T 09-03-2017 TK78_RS25480 1d55946bcbf1e0e154a1edc061fe5716 237 Pfam PF12867 DinB superfamily 17 224 4.5E-7 T 09-03-2017 IPR024775 DinB-like domain TK78_RS27720 364269d333df1120d69b2642c8314476 1006 Pfam PF00271 Helicase conserved C-terminal domain 837 946 2.7E-17 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS27720 364269d333df1120d69b2642c8314476 1006 Gene3D G3DSA:3.40.50.300 536 699 3.4E-20 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27720 364269d333df1120d69b2642c8314476 1006 Gene3D G3DSA:3.40.50.300 831 981 1.5E-21 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27720 364269d333df1120d69b2642c8314476 1006 SUPERFAMILY SSF52540 757 1002 6.29E-67 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27720 364269d333df1120d69b2642c8314476 1006 SMART SM00487 536 713 2.2E-27 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS27720 364269d333df1120d69b2642c8314476 1006 Pfam PF00176 SNF2 family N-terminal domain 559 818 2.5E-48 T 09-03-2017 IPR000330 SNF2-related, N-terminal domain GO:0005524 TK78_RS27720 364269d333df1120d69b2642c8314476 1006 SUPERFAMILY SSF52540 525 750 9.82E-52 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27720 364269d333df1120d69b2642c8314476 1006 Pfam PF12419 SNF2 Helicase protein 368 496 4.7E-35 T 09-03-2017 IPR022138 Helicase SWF/SNF-related TK78_RS27720 364269d333df1120d69b2642c8314476 1006 SMART SM00490 864 946 3.2E-22 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS33660 9f77e223f527ae049b5eb2494b134d8d 352 SUPERFAMILY SSF81345 16 346 6.54E-75 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS33660 9f77e223f527ae049b5eb2494b134d8d 352 Pfam PF01032 FecCD transport family 32 346 2.6E-84 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS33660 9f77e223f527ae049b5eb2494b134d8d 352 Gene3D G3DSA:1.10.3470.10 18 348 5.5E-95 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS27235 9b61467df9ac02dd6c1f186e132259f5 254 SMART SM00464 5 230 6.7E-52 T 09-03-2017 IPR003111 ATP-dependent protease La (LON), substrate-binding domain GO:0004176|GO:0006508 TK78_RS27235 9b61467df9ac02dd6c1f186e132259f5 254 Pfam PF02190 ATP-dependent protease La (LON) substrate-binding domain 6 229 5.6E-32 T 09-03-2017 IPR003111 ATP-dependent protease La (LON), substrate-binding domain GO:0004176|GO:0006508 TK78_RS27235 9b61467df9ac02dd6c1f186e132259f5 254 SUPERFAMILY SSF88697 91 229 5.22E-42 T 09-03-2017 IPR015947 PUA-like domain TK78_RS27235 9b61467df9ac02dd6c1f186e132259f5 254 SUPERFAMILY SSF88697 5 64 5.22E-42 T 09-03-2017 IPR015947 PUA-like domain TK78_RS12235 8b64d22355d68d887c728525e4044a58 790 Pfam PF04230 Polysaccharide pyruvyl transferase 443 680 3.1E-9 T 09-03-2017 IPR007345 Polysaccharide pyruvyl transferase TK78_RS12235 8b64d22355d68d887c728525e4044a58 790 Gene3D G3DSA:1.25.40.10 268 376 1.8E-14 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS12235 8b64d22355d68d887c728525e4044a58 790 SUPERFAMILY SSF48452 268 377 5.0E-14 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS12235 8b64d22355d68d887c728525e4044a58 790 Gene3D G3DSA:3.90.550.10 34 160 1.5E-4 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS23075 902eb9cafd1c18af18a16a2957343ca7 213 Gene3D G3DSA:1.10.3720.10 13 211 2.1E-40 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS23075 902eb9cafd1c18af18a16a2957343ca7 213 SUPERFAMILY SSF161098 14 203 3.01E-35 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS23075 902eb9cafd1c18af18a16a2957343ca7 213 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 36 211 2.6E-19 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS23075 902eb9cafd1c18af18a16a2957343ca7 213 TIGRFAM TIGR01726 HEQRo_perm_3TM: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family 13 106 4.5E-16 T 09-03-2017 IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain GO:0005215|GO:0006810|GO:0016021 TK78_RS23075 902eb9cafd1c18af18a16a2957343ca7 213 TIGRFAM TIGR03003 ectoine_ehuD: ectoine/hydroxyectoine ABC transporter, permease protein EhuD 4 211 2.3E-64 T 09-03-2017 IPR014341 Ectoine/hydroxyectoine ABC transporter, permease protein EhuD TK78_RS25265 30248e2612bc2016123606ecbb9c844f 483 Gene3D G3DSA:3.30.420.40 238 430 6.3E-23 T 09-03-2017 TK78_RS25265 30248e2612bc2016123606ecbb9c844f 483 Gene3D G3DSA:3.30.420.40 3 233 1.5E-33 T 09-03-2017 TK78_RS25265 30248e2612bc2016123606ecbb9c844f 483 SUPERFAMILY SSF53067 239 439 4.07E-34 T 09-03-2017 TK78_RS25265 30248e2612bc2016123606ecbb9c844f 483 SUPERFAMILY SSF53067 4 236 1.78E-34 T 09-03-2017 TK78_RS25265 30248e2612bc2016123606ecbb9c844f 483 ProSitePatterns PS00445 FGGY family of carbohydrate kinases signature 2. 337 358 - T 09-03-2017 IPR018483 Carbohydrate kinase, FGGY, conserved site GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 TK78_RS25265 30248e2612bc2016123606ecbb9c844f 483 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 4 233 1.8E-34 T 09-03-2017 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 TK78_RS25265 30248e2612bc2016123606ecbb9c844f 483 PIRSF PIRSF000538 4 440 6.1E-65 T 09-03-2017 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 TK78_RS25265 30248e2612bc2016123606ecbb9c844f 483 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 241 425 4.9E-19 T 09-03-2017 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 TK78_RS34645 d9cf5c0bafefd4ea22a6d51c788f8611 188 Pfam PF13359 DDE superfamily endonuclease 60 129 7.5E-9 T 09-03-2017 IPR027806 Harbinger transposase-derived nuclease domain TK78_RS19715 8755f2c50ea3a685ba368320ec9be9f7 336 Pfam PF02636 Putative S-adenosyl-L-methionine-dependent methyltransferase 112 269 6.7E-9 T 09-03-2017 IPR003788 Putative S-adenosyl-L-methionine-dependent methyltransferase MidA Reactome: R-HSA-6799198 TK78_RS19715 8755f2c50ea3a685ba368320ec9be9f7 336 SUPERFAMILY SSF53335 3 328 1.58E-36 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS14955 a6df24503b85f2b2bb08aa5d0997a04f 166 SUPERFAMILY SSF88659 98 155 2.06E-14 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS14955 a6df24503b85f2b2bb08aa5d0997a04f 166 Pfam PF08281 Sigma-70, region 4 101 151 5.8E-15 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS14955 a6df24503b85f2b2bb08aa5d0997a04f 166 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 6 155 1.5E-18 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS14955 a6df24503b85f2b2bb08aa5d0997a04f 166 Gene3D G3DSA:1.10.10.10 101 156 3.7E-16 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS14955 a6df24503b85f2b2bb08aa5d0997a04f 166 ProSitePatterns PS01063 Sigma-70 factors ECF subfamily signature. 31 62 - T 09-03-2017 IPR000838 RNA polymerase sigma factor 70, ECF, conserved site GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS14955 a6df24503b85f2b2bb08aa5d0997a04f 166 TIGRFAM TIGR02983 SigE-fam_strep: RNA polymerase sigma-70 factor, sigma-E family 3 156 1.6E-44 T 09-03-2017 IPR014325 RNA polymerase sigma-E factor, actinobacteria GO:0016987 TK78_RS14955 a6df24503b85f2b2bb08aa5d0997a04f 166 SUPERFAMILY SSF88946 4 72 4.32E-16 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS14955 a6df24503b85f2b2bb08aa5d0997a04f 166 Pfam PF04542 Sigma-70 region 2 10 76 8.6E-12 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS14955 a6df24503b85f2b2bb08aa5d0997a04f 166 Gene3D G3DSA:1.10.1740.10 4 76 1.3E-17 T 09-03-2017 TK78_RS30670 70314aba0c1cee306303e197b2c7f2a5 202 Pfam PF03029 Conserved hypothetical ATP binding protein 23 191 1.1E-24 T 09-03-2017 IPR004130 GPN-loop GTPase TK78_RS30670 70314aba0c1cee306303e197b2c7f2a5 202 Gene3D G3DSA:3.40.50.300 15 194 2.7E-12 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS30670 70314aba0c1cee306303e197b2c7f2a5 202 SUPERFAMILY SSF52540 20 176 2.52E-20 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08085 8405d0a27998ddea2fcd3bde95c7270c 302 Gene3D G3DSA:3.40.50.10490 159 243 1.2E-66 T 09-03-2017 TK78_RS08085 8405d0a27998ddea2fcd3bde95c7270c 302 Gene3D G3DSA:3.40.50.10490 23 99 1.2E-66 T 09-03-2017 TK78_RS08085 8405d0a27998ddea2fcd3bde95c7270c 302 SUPERFAMILY SSF52313 6 229 9.55E-90 T 09-03-2017 IPR023591 Ribosomal protein S2, flavodoxin-like domain TK78_RS08085 8405d0a27998ddea2fcd3bde95c7270c 302 PRINTS PR00395 Ribosomal protein S2 signature 6 24 3.5E-38 T 09-03-2017 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS08085 8405d0a27998ddea2fcd3bde95c7270c 302 PRINTS PR00395 Ribosomal protein S2 signature 197 211 3.5E-38 T 09-03-2017 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS08085 8405d0a27998ddea2fcd3bde95c7270c 302 PRINTS PR00395 Ribosomal protein S2 signature 176 187 3.5E-38 T 09-03-2017 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS08085 8405d0a27998ddea2fcd3bde95c7270c 302 PRINTS PR00395 Ribosomal protein S2 signature 37 46 3.5E-38 T 09-03-2017 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS08085 8405d0a27998ddea2fcd3bde95c7270c 302 PRINTS PR00395 Ribosomal protein S2 signature 159 176 3.5E-38 T 09-03-2017 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS08085 8405d0a27998ddea2fcd3bde95c7270c 302 PRINTS PR00395 Ribosomal protein S2 signature 87 104 3.5E-38 T 09-03-2017 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS08085 8405d0a27998ddea2fcd3bde95c7270c 302 TIGRFAM TIGR01011 rpsB_bact: ribosomal protein uS2 3 225 1.9E-106 T 09-03-2017 IPR005706 Ribosomal protein S2, bacteria/mitochondria/plastid GO:0003735|GO:0006412|GO:0015935 TK78_RS08085 8405d0a27998ddea2fcd3bde95c7270c 302 Hamap MF_00291_B 30S ribosomal protein S2 [rpsB]. 2 226 41.826 T 09-03-2017 IPR005706 Ribosomal protein S2, bacteria/mitochondria/plastid GO:0003735|GO:0006412|GO:0015935 TK78_RS08085 8405d0a27998ddea2fcd3bde95c7270c 302 Gene3D G3DSA:1.10.287.610 100 153 1.9E-20 T 09-03-2017 TK78_RS08085 8405d0a27998ddea2fcd3bde95c7270c 302 ProSitePatterns PS00962 Ribosomal protein S2 signature 1. 6 17 - T 09-03-2017 IPR018130 Ribosomal protein S2, conserved site GO:0003735|GO:0005840|GO:0006412 TK78_RS08085 8405d0a27998ddea2fcd3bde95c7270c 302 Pfam PF00318 Ribosomal protein S2 9 225 1.7E-94 T 09-03-2017 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS26030 0fe482308e6c1c888b3293d435f33ea7 189 Pfam PF05685 Putative restriction endonuclease 14 183 6.2E-25 T 09-03-2017 IPR008538 Domain of unknown function DUF820 TK78_RS26030 0fe482308e6c1c888b3293d435f33ea7 189 Gene3D G3DSA:3.90.1570.10 11 163 7.0E-16 T 09-03-2017 IPR012296 Nuclease, putative, TT1808 TK78_RS26030 0fe482308e6c1c888b3293d435f33ea7 189 SUPERFAMILY SSF52980 14 160 1.13E-14 T 09-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 TK78_RS34220 2589df6c42fba6159eb051f5b3986b32 339 PIRSF PIRSF016838 2 330 4.8E-19 T 09-03-2017 IPR028349 Protein PafC TK78_RS34220 2589df6c42fba6159eb051f5b3986b32 339 Pfam PF08279 HTH domain 7 62 2.3E-15 T 09-03-2017 IPR013196 Helix-turn-helix, type 11 TK78_RS34220 2589df6c42fba6159eb051f5b3986b32 339 SUPERFAMILY SSF46785 5 63 2.82E-10 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS34220 2589df6c42fba6159eb051f5b3986b32 339 Pfam PF13280 WYL domain 142 321 2.4E-28 T 09-03-2017 IPR026881 WYL domain TK78_RS34220 2589df6c42fba6159eb051f5b3986b32 339 Gene3D G3DSA:1.10.10.10 3 65 7.0E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS34220 2589df6c42fba6159eb051f5b3986b32 339 ProSitePatterns PS00894 DeoR-type HTH domain signature. 7 41 - T 09-03-2017 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 TK78_RS24175 398d99594ca3ec0c5e9637948bcf9ef2 996 Gene3D G3DSA:2.60.40.10 798 854 1.4E-4 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS24175 398d99594ca3ec0c5e9637948bcf9ef2 996 SUPERFAMILY SSF140657 514 653 1.03E-26 T 09-03-2017 TK78_RS24175 398d99594ca3ec0c5e9637948bcf9ef2 996 SUPERFAMILY SSF55545 53 190 8.37E-16 T 09-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS24175 398d99594ca3ec0c5e9637948bcf9ef2 996 Pfam PF07555 beta-N-acetylglucosaminidase 195 502 8.2E-97 T 09-03-2017 IPR011496 Beta-N-acetylglucosaminidase MetaCyc: PWY-7437 TK78_RS24175 398d99594ca3ec0c5e9637948bcf9ef2 996 Gene3D G3DSA:3.30.379.10 50 189 4.5E-19 T 09-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS24175 398d99594ca3ec0c5e9637948bcf9ef2 996 SUPERFAMILY SSF49785 866 991 3.05E-21 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS24175 398d99594ca3ec0c5e9637948bcf9ef2 996 Pfam PF00754 F5/8 type C domain 872 986 1.6E-20 T 09-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain TK78_RS24175 398d99594ca3ec0c5e9637948bcf9ef2 996 SUPERFAMILY SSF51445 193 499 2.74E-85 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS24175 398d99594ca3ec0c5e9637948bcf9ef2 996 Gene3D G3DSA:2.60.120.260 869 994 3.9E-24 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS24175 398d99594ca3ec0c5e9637948bcf9ef2 996 Pfam PF02838 Glycosyl hydrolase family 20, domain 2 54 189 4.3E-22 T 09-03-2017 IPR015882 Beta-hexosaminidase, bacteial type, N-terminal KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 TK78_RS18880 5906e6c3ce145debe2c4e71808648b3d 190 Pfam PF08768 Domain of unknown function (DUF1794) 12 164 1.6E-47 T 09-03-2017 IPR014878 Domain of unknown function DUF1794 TK78_RS18880 5906e6c3ce145debe2c4e71808648b3d 190 SUPERFAMILY SSF50814 7 165 4.96E-42 T 09-03-2017 IPR011038 Calycin-like TK78_RS18880 5906e6c3ce145debe2c4e71808648b3d 190 Hamap MF_01297 UPF0678 fatty acid-binding protein-like protein . 4 166 32.073 T 09-03-2017 IPR022939 Uncharacterised protein family UPF0678 TK78_RS13090 b2c777bbce83f88c820b11e164013a65 132 Gene3D G3DSA:3.30.1370.30 2 72 1.2E-27 T 09-03-2017 TK78_RS13090 b2c777bbce83f88c820b11e164013a65 132 Hamap MF_01302_B 30S ribosomal protein S8 [rpsH]. 2 132 30.353 T 09-03-2017 IPR000630 Ribosomal protein S8 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13090 b2c777bbce83f88c820b11e164013a65 132 Pfam PF00410 Ribosomal protein S8 5 132 1.2E-48 T 09-03-2017 IPR000630 Ribosomal protein S8 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13090 b2c777bbce83f88c820b11e164013a65 132 SUPERFAMILY SSF56047 3 132 1.1E-43 T 09-03-2017 IPR000630 Ribosomal protein S8 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS13090 b2c777bbce83f88c820b11e164013a65 132 Gene3D G3DSA:3.30.1490.10 76 132 1.5E-27 T 09-03-2017 TK78_RS13965 7f57264b8238b81ebca0c833c44453d2 375 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 2 106 8.3E-20 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS13965 7f57264b8238b81ebca0c833c44453d2 375 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 110 205 7.7E-19 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS13965 7f57264b8238b81ebca0c833c44453d2 375 Gene3D G3DSA:2.40.110.10 109 203 1.8E-27 T 09-03-2017 TK78_RS13965 7f57264b8238b81ebca0c833c44453d2 375 SUPERFAMILY SSF56645 3 227 1.19E-58 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS13965 7f57264b8238b81ebca0c833c44453d2 375 Gene3D G3DSA:1.20.140.10 204 374 1.5E-21 T 09-03-2017 TK78_RS13965 7f57264b8238b81ebca0c833c44453d2 375 SUPERFAMILY SSF47203 217 372 1.47E-17 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS13965 7f57264b8238b81ebca0c833c44453d2 375 Gene3D G3DSA:1.10.540.10 2 107 2.0E-22 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS13965 7f57264b8238b81ebca0c833c44453d2 375 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 217 368 6.5E-20 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS26100 2748073ce6980dc726a59c5b81a2807f 481 ProSitePatterns PS00216 Sugar transport proteins signature 1. 138 154 - T 09-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 TK78_RS26100 2748073ce6980dc726a59c5b81a2807f 481 TIGRFAM TIGR00710 efflux_Bcr_CflA: drug resistance transporter, Bcr/CflA subfamily 84 468 4.3E-101 T 09-03-2017 IPR004812 Drug resistance transporter Bcr/CmlA subfamily GO:0005215|GO:0006810|GO:0016021 TK78_RS26100 2748073ce6980dc726a59c5b81a2807f 481 Pfam PF07690 Major Facilitator Superfamily 96 434 2.3E-40 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS26100 2748073ce6980dc726a59c5b81a2807f 481 Gene3D G3DSA:1.20.1250.20 86 266 5.3E-28 T 09-03-2017 TK78_RS26100 2748073ce6980dc726a59c5b81a2807f 481 Gene3D G3DSA:1.20.1250.20 283 477 1.5E-9 T 09-03-2017 TK78_RS26100 2748073ce6980dc726a59c5b81a2807f 481 SUPERFAMILY SSF103473 71 477 4.58E-62 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS26100 2748073ce6980dc726a59c5b81a2807f 481 PRINTS PR01035 Tetracycline resistance protein signature 385 405 2.6E-5 T 09-03-2017 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 TK78_RS26100 2748073ce6980dc726a59c5b81a2807f 481 PRINTS PR01035 Tetracycline resistance protein signature 151 175 2.6E-5 T 09-03-2017 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 TK78_RS26100 2748073ce6980dc726a59c5b81a2807f 481 PRINTS PR01035 Tetracycline resistance protein signature 178 199 2.6E-5 T 09-03-2017 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 TK78_RS26100 2748073ce6980dc726a59c5b81a2807f 481 PRINTS PR01035 Tetracycline resistance protein signature 94 110 2.6E-5 T 09-03-2017 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 TK78_RS17995 23c6f8692208ece81fed582f83a886a1 504 Gene3D G3DSA:3.30.950.10 369 479 4.4E-13 T 09-03-2017 IPR014776 Tetrapyrrole methylase, subdomain 2 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS17995 23c6f8692208ece81fed582f83a886a1 504 Gene3D G3DSA:3.40.1010.10 255 368 1.4E-26 T 09-03-2017 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS17995 23c6f8692208ece81fed582f83a886a1 504 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 257 463 2.9E-36 T 09-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS17995 23c6f8692208ece81fed582f83a886a1 504 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 10 221 1.3E-49 T 09-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS17995 23c6f8692208ece81fed582f83a886a1 504 SUPERFAMILY SSF53790 7 245 2.49E-49 T 09-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS17995 23c6f8692208ece81fed582f83a886a1 504 TIGRFAM TIGR01467 cobI_cbiL: precorrin-2 C(20)-methyltransferase 9 240 5.6E-67 T 09-03-2017 IPR006364 Precorrin-2 C(20)-methyltransferase domain GO:0008757|GO:0009236 TK78_RS17995 23c6f8692208ece81fed582f83a886a1 504 TIGRFAM TIGR01466 cobJ_cbiH: precorrin-3B C17-methyltransferase 257 501 2.3E-82 T 09-03-2017 IPR006363 Precorrin-3B C17-methyltransferase domain GO:0008168|GO:0009236 TK78_RS17995 23c6f8692208ece81fed582f83a886a1 504 ProSitePatterns PS00839 Uroporphyrin-III C-methyltransferase signature 1. 14 28 - T 09-03-2017 IPR003043 Uroporphiryn-III C-methyltransferase, conserved site GO:0008168|GO:0055114 KEGG: 00270+2.1.1.10|KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5441|MetaCyc: PWY-702|MetaCyc: PWY-7377 TK78_RS17995 23c6f8692208ece81fed582f83a886a1 504 SUPERFAMILY SSF53790 253 486 8.77E-52 T 09-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS17995 23c6f8692208ece81fed582f83a886a1 504 Gene3D G3DSA:3.40.1010.10 8 140 5.5E-37 T 09-03-2017 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS06570 3bd2e9a26b2b276c57dc1748543f03c1 363 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 246 307 1.4E-19 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS06570 3bd2e9a26b2b276c57dc1748543f03c1 363 ProSitePatterns PS00211 ABC transporters family signature. 166 180 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS06570 3bd2e9a26b2b276c57dc1748543f03c1 363 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 246 337 1.1E-18 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS06570 3bd2e9a26b2b276c57dc1748543f03c1 363 SUPERFAMILY SSF52540 17 264 2.66E-63 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06570 3bd2e9a26b2b276c57dc1748543f03c1 363 Pfam PF00005 ABC transporter 38 193 2.1E-24 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS06570 3bd2e9a26b2b276c57dc1748543f03c1 363 SMART SM00382 46 243 4.0E-14 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS06570 3bd2e9a26b2b276c57dc1748543f03c1 363 Gene3D G3DSA:3.40.50.300 10 273 4.0E-72 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS11875 627cfd144c478c3569015df3ad154775 381 Gene3D G3DSA:3.40.640.10 6 249 1.0E-103 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS11875 627cfd144c478c3569015df3ad154775 381 Gene3D G3DSA:3.90.1150.10 250 380 3.0E-48 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS11875 627cfd144c478c3569015df3ad154775 381 PIRSF PIRSF001434 1 381 9.7E-146 T 09-03-2017 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 Reactome: R-HSA-1614558|Reactome: R-HSA-1614603|Reactome: R-HSA-2408508 TK78_RS11875 627cfd144c478c3569015df3ad154775 381 Pfam PF01053 Cys/Met metabolism PLP-dependent enzyme 8 380 1.1E-150 T 09-03-2017 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 Reactome: R-HSA-1614558|Reactome: R-HSA-1614603|Reactome: R-HSA-2408508 TK78_RS11875 627cfd144c478c3569015df3ad154775 381 ProSitePatterns PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 193 207 - T 09-03-2017 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 Reactome: R-HSA-1614558|Reactome: R-HSA-1614603|Reactome: R-HSA-2408508 TK78_RS11875 627cfd144c478c3569015df3ad154775 381 SUPERFAMILY SSF53383 8 380 6.39E-125 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS00250 6b1fecd7ccc958d1caae54304e9cb856 354 Gene3D G3DSA:3.20.20.30 4 347 3.5E-78 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS00250 6b1fecd7ccc958d1caae54304e9cb856 354 SUPERFAMILY SSF51679 8 342 9.16E-68 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS00250 6b1fecd7ccc958d1caae54304e9cb856 354 TIGRFAM TIGR03858 LLM_2I7G: probable oxidoreductase, LLM family 7 341 9.3E-146 T 09-03-2017 IPR022290 Conserved hypothetical protein CHP03858, luciferase-like monooxygenase, putative TK78_RS00250 6b1fecd7ccc958d1caae54304e9cb856 354 Pfam PF00296 Luciferase-like monooxygenase 24 302 6.2E-44 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS00400 0cd8d3cb63aee344801c9994200c7eff 490 Gene3D G3DSA:3.30.420.40 256 486 1.9E-20 T 09-03-2017 TK78_RS00400 0cd8d3cb63aee344801c9994200c7eff 490 PIRSF PIRSF000538 12 490 7.9E-63 T 09-03-2017 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 TK78_RS00400 0cd8d3cb63aee344801c9994200c7eff 490 Gene3D G3DSA:3.30.420.40 12 248 4.1E-34 T 09-03-2017 TK78_RS00400 0cd8d3cb63aee344801c9994200c7eff 490 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 263 439 2.7E-18 T 09-03-2017 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 TK78_RS00400 0cd8d3cb63aee344801c9994200c7eff 490 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 15 251 6.6E-26 T 09-03-2017 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 TK78_RS00400 0cd8d3cb63aee344801c9994200c7eff 490 SUPERFAMILY SSF53067 258 479 5.18E-26 T 09-03-2017 TK78_RS00400 0cd8d3cb63aee344801c9994200c7eff 490 SUPERFAMILY SSF53067 15 257 2.37E-38 T 09-03-2017 TK78_RS09090 7d1f458b8ddd680177f85742eb736b5e 924 Pfam PF00196 Bacterial regulatory proteins, luxR family 868 922 5.7E-15 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS09090 7d1f458b8ddd680177f85742eb736b5e 924 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 884 900 3.9E-10 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS09090 7d1f458b8ddd680177f85742eb736b5e 924 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 870 884 3.9E-10 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS09090 7d1f458b8ddd680177f85742eb736b5e 924 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 900 912 3.9E-10 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS09090 7d1f458b8ddd680177f85742eb736b5e 924 Gene3D G3DSA:1.10.10.10 863 923 8.2E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS09090 7d1f458b8ddd680177f85742eb736b5e 924 SUPERFAMILY SSF52540 9 190 4.82E-9 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09090 7d1f458b8ddd680177f85742eb736b5e 924 Gene3D G3DSA:3.40.50.300 10 98 4.7E-5 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09090 7d1f458b8ddd680177f85742eb736b5e 924 SUPERFAMILY SSF46894 864 922 1.26E-16 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS09090 7d1f458b8ddd680177f85742eb736b5e 924 SMART SM00421 867 924 9.3E-21 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS22290 7287336aae58a82a1fe0fc47f6db1f26 444 SUPERFAMILY SSF103473 53 437 4.84E-23 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS22290 7287336aae58a82a1fe0fc47f6db1f26 444 Gene3D G3DSA:1.20.1250.20 57 240 1.7E-5 T 09-03-2017 TK78_RS22290 7287336aae58a82a1fe0fc47f6db1f26 444 Gene3D G3DSA:1.20.1250.20 291 434 3.9E-5 T 09-03-2017 TK78_RS18910 e3538d56fa33a0dbcdd7b75a5dcf6946 418 Gene3D G3DSA:3.40.630.30 1 135 1.5E-19 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS18910 e3538d56fa33a0dbcdd7b75a5dcf6946 418 Pfam PF13530 Sterol carrier protein domain 186 415 2.9E-52 T 09-03-2017 IPR025559 Enhanced intracellular survival protein domain TK78_RS18910 e3538d56fa33a0dbcdd7b75a5dcf6946 418 SUPERFAMILY SSF55718 314 418 1.61E-22 T 09-03-2017 IPR003033 SCP2 sterol-binding domain TK78_RS18910 e3538d56fa33a0dbcdd7b75a5dcf6946 418 Hamap MF_01812 UPF0256 protein . 1 418 51.395 T 09-03-2017 IPR022902 Uncharacterised protein family UPF0256 TK78_RS18910 e3538d56fa33a0dbcdd7b75a5dcf6946 418 Gene3D G3DSA:3.40.630.30 141 301 1.4E-31 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS18910 e3538d56fa33a0dbcdd7b75a5dcf6946 418 SUPERFAMILY SSF55729 4 313 8.95E-56 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS18910 e3538d56fa33a0dbcdd7b75a5dcf6946 418 Gene3D G3DSA:3.30.1050.10 315 407 1.3E-19 T 09-03-2017 IPR003033 SCP2 sterol-binding domain TK78_RS18910 e3538d56fa33a0dbcdd7b75a5dcf6946 418 Pfam PF13527 Acetyltransferase (GNAT) domain 5 133 1.5E-26 T 09-03-2017 TK78_RS09225 162483cb7ec2426cf855217f5b94b22a 71 SUPERFAMILY SSF47473 4 66 4.61E-18 T 09-03-2017 IPR011992 EF-hand domain pair TK78_RS09225 162483cb7ec2426cf855217f5b94b22a 71 ProSitePatterns PS00018 EF-hand calcium-binding domain. 52 64 - T 09-03-2017 IPR018247 EF-Hand 1, calcium-binding site TK78_RS09225 162483cb7ec2426cf855217f5b94b22a 71 SMART SM00054 6 34 3.3E-4 T 09-03-2017 IPR002048 EF-hand domain GO:0005509 TK78_RS09225 162483cb7ec2426cf855217f5b94b22a 71 SMART SM00054 43 71 3.7 T 09-03-2017 IPR002048 EF-hand domain GO:0005509 TK78_RS09225 162483cb7ec2426cf855217f5b94b22a 71 Pfam PF13499 EF-hand domain pair 7 64 9.5E-11 T 09-03-2017 IPR002048 EF-hand domain GO:0005509 TK78_RS09225 162483cb7ec2426cf855217f5b94b22a 71 Gene3D G3DSA:1.10.238.10 4 67 2.7E-18 T 09-03-2017 IPR011992 EF-hand domain pair TK78_RS09225 162483cb7ec2426cf855217f5b94b22a 71 ProSitePatterns PS00018 EF-hand calcium-binding domain. 15 27 - T 09-03-2017 IPR018247 EF-Hand 1, calcium-binding site TK78_RS11980 e2539c0c7c6f34ec810143ed0f916378 526 Pfam PF01039 Carboxyl transferase domain 36 524 2.4E-194 T 09-03-2017 IPR000022 Carboxyl transferase KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TK78_RS11980 e2539c0c7c6f34ec810143ed0f916378 526 Gene3D G3DSA:3.90.226.10 4 262 5.0E-83 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS11980 e2539c0c7c6f34ec810143ed0f916378 526 PRINTS PR01070 Acetyl-CoA carboxylase carboxyl transferase beta subunit signature 137 155 3.7E-6 T 09-03-2017 IPR000438 Acetyl-CoA carboxylase carboxyl transferase, beta subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388 TK78_RS11980 e2539c0c7c6f34ec810143ed0f916378 526 PRINTS PR01070 Acetyl-CoA carboxylase carboxyl transferase beta subunit signature 103 117 3.7E-6 T 09-03-2017 IPR000438 Acetyl-CoA carboxylase carboxyl transferase, beta subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388 TK78_RS11980 e2539c0c7c6f34ec810143ed0f916378 526 Gene3D G3DSA:3.90.226.10 273 526 5.2E-101 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS11980 e2539c0c7c6f34ec810143ed0f916378 526 SUPERFAMILY SSF52096 14 264 6.1E-80 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS11980 e2539c0c7c6f34ec810143ed0f916378 526 SUPERFAMILY SSF52096 251 526 8.99E-90 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS04465 cad25f559441cd3a04adc186cd665df4 472 Gene3D G3DSA:3.40.190.10 180 350 5.9E-29 T 09-03-2017 TK78_RS04465 cad25f559441cd3a04adc186cd665df4 472 SUPERFAMILY SSF53850 62 466 6.29E-52 T 09-03-2017 TK78_RS04465 cad25f559441cd3a04adc186cd665df4 472 Gene3D G3DSA:3.40.190.10 58 179 4.6E-21 T 09-03-2017 TK78_RS04465 cad25f559441cd3a04adc186cd665df4 472 Gene3D G3DSA:3.40.190.10 351 376 4.6E-21 T 09-03-2017 TK78_RS04465 cad25f559441cd3a04adc186cd665df4 472 Pfam PF01547 Bacterial extracellular solute-binding protein 77 362 5.3E-33 T 09-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 TK78_RS19980 ae739edd2b7299a7d356a7164f952160 366 Gene3D G3DSA:3.40.1130.10 127 278 7.7E-6 T 09-03-2017 TK78_RS19980 ae739edd2b7299a7d356a7164f952160 366 Pfam PF01553 Acyltransferase 138 269 1.5E-16 T 09-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 TK78_RS19980 ae739edd2b7299a7d356a7164f952160 366 SMART SM00563 153 272 4.6E-16 T 09-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 TK78_RS19980 ae739edd2b7299a7d356a7164f952160 366 SUPERFAMILY SSF69593 131 357 7.32E-34 T 09-03-2017 TK78_RS30330 dda9ab25846717ef1af47e47d00f2e30 279 Pfam PF00215 Orotidine 5'-phosphate decarboxylase / HUMPS family 19 259 8.4E-37 T 09-03-2017 IPR001754 Orotidine 5'-phosphate decarboxylase domain GO:0004590|GO:0006207 KEGG: 00240+4.1.1.23|MetaCyc: PWY-5686|Reactome: R-HSA-500753 TK78_RS30330 dda9ab25846717ef1af47e47d00f2e30 279 SUPERFAMILY SSF51366 6 276 4.71E-61 T 09-03-2017 IPR011060 Ribulose-phosphate binding barrel GO:0003824|GO:0008152 TK78_RS30330 dda9ab25846717ef1af47e47d00f2e30 279 Gene3D G3DSA:3.20.20.70 8 270 6.3E-59 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS30330 dda9ab25846717ef1af47e47d00f2e30 279 TIGRFAM TIGR02127 pyrF_sub2: orotidine 5'-phosphate decarboxylase 6 264 1.5E-82 T 09-03-2017 IPR011995 Orotidine 5'-phosphate decarboxylase, type 2 GO:0004590|GO:0006221 KEGG: 00240+4.1.1.23|MetaCyc: PWY-5686 TK78_RS30330 dda9ab25846717ef1af47e47d00f2e30 279 SMART SM00934 19 264 1.3E-33 T 09-03-2017 IPR001754 Orotidine 5'-phosphate decarboxylase domain GO:0004590|GO:0006207 KEGG: 00240+4.1.1.23|MetaCyc: PWY-5686|Reactome: R-HSA-500753 TK78_RS30330 dda9ab25846717ef1af47e47d00f2e30 279 Hamap MF_01215 Orotidine 5'-phosphate decarboxylase [pyrF]. 4 278 34.332 T 09-03-2017 IPR011995 Orotidine 5'-phosphate decarboxylase, type 2 GO:0004590|GO:0006221 KEGG: 00240+4.1.1.23|MetaCyc: PWY-5686 TK78_RS30330 dda9ab25846717ef1af47e47d00f2e30 279 ProSitePatterns PS00156 Orotidine 5'-phosphate decarboxylase active site. 93 106 - T 09-03-2017 IPR018089 Orotidine 5'-phosphate decarboxylase, active site GO:0004590|GO:0006207 KEGG: 00240+4.1.1.23|MetaCyc: PWY-5686|Reactome: R-HSA-500753 TK78_RS30685 49e48b4dbd151b7da9cae5ae791d2f4e 147 SUPERFAMILY SSF50249 12 122 4.45E-14 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS30685 49e48b4dbd151b7da9cae5ae791d2f4e 147 Pfam PF12172 Rubredoxin-like zinc ribbon domain (DUF35_N) 12 47 9.5E-9 T 09-03-2017 IPR022002 Domain of unknown function DUF35, rubredoxin-like zinc ribbon domain, N-terminal TK78_RS11550 14461ca7586c025c3e0024cd261a296e 132 Pfam PF02643 Uncharacterized ACR, COG1430 28 120 3.7E-16 T 09-03-2017 IPR003795 Protein of unknown function DUF192 TK78_RS04510 b9c8999fe6b22c187bab5e65aaf1e562 231 SUPERFAMILY SSF52317 2 230 1.25E-67 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS04510 b9c8999fe6b22c187bab5e65aaf1e562 231 Pfam PF01965 DJ-1/PfpI family 29 228 1.8E-15 T 09-03-2017 IPR002818 DJ-1/PfpI TK78_RS04510 b9c8999fe6b22c187bab5e65aaf1e562 231 Gene3D G3DSA:3.40.50.880 1 231 8.7E-87 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS19645 5d1a01ccb9fd13cc4d4f2496af8bdc79 316 SUPERFAMILY SSF51294 265 312 2.75E-5 T 09-03-2017 IPR028992 Hedgehog/Intein (Hint) domain TK78_RS19645 5d1a01ccb9fd13cc4d4f2496af8bdc79 316 SUPERFAMILY SSF51294 4 91 2.75E-5 T 09-03-2017 IPR028992 Hedgehog/Intein (Hint) domain TK78_RS00125 db48fab142c3baf3b3d6c13ed63463a7 88 Pfam PF13683 Integrase core domain 15 77 2.6E-19 T 09-03-2017 IPR001584 Integrase, catalytic core GO:0015074 TK78_RS00125 db48fab142c3baf3b3d6c13ed63463a7 88 Gene3D G3DSA:3.30.420.10 4 77 2.1E-20 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS00125 db48fab142c3baf3b3d6c13ed63463a7 88 SUPERFAMILY SSF53098 4 76 1.23E-16 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS12060 70415b481500c6af4dca08f09249ed8e 313 Pfam PF00171 Aldehyde dehydrogenase family 33 264 1.5E-39 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS12060 70415b481500c6af4dca08f09249ed8e 313 Gene3D G3DSA:3.40.605.10 17 264 2.5E-54 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS12060 70415b481500c6af4dca08f09249ed8e 313 SUPERFAMILY SSF53720 16 264 3.01E-44 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS11525 3de79d38bc16373e991df330d0f31711 349 Gene3D G3DSA:3.20.20.100 21 335 2.3E-83 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS11525 3de79d38bc16373e991df330d0f31711 349 SUPERFAMILY SSF51430 21 336 8.25E-88 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS11525 3de79d38bc16373e991df330d0f31711 349 Pfam PF00248 Aldo/keto reductase family 36 334 1.1E-64 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS25490 447f93ca165e22e8dbad5535281e11d3 270 Pfam PF00144 Beta-lactamase 16 261 7.5E-38 T 09-03-2017 IPR001466 Beta-lactamase-related TK78_RS25490 447f93ca165e22e8dbad5535281e11d3 270 SUPERFAMILY SSF56601 6 265 4.31E-53 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS25490 447f93ca165e22e8dbad5535281e11d3 270 Gene3D G3DSA:3.40.710.10 7 266 8.1E-46 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS06195 34cb826ce351a52f526fa9145ad057c4 134 Pfam PF03259 Roadblock/LC7 domain 8 96 4.8E-16 T 09-03-2017 IPR004942 Roadblock/LAMTOR2 domain TK78_RS06195 34cb826ce351a52f526fa9145ad057c4 134 Gene3D G3DSA:3.30.450.30 4 122 1.6E-20 T 09-03-2017 TK78_RS06195 34cb826ce351a52f526fa9145ad057c4 134 SUPERFAMILY SSF103196 1 119 9.16E-26 T 09-03-2017 TK78_RS06195 34cb826ce351a52f526fa9145ad057c4 134 SMART SM00960 8 97 2.4E-16 T 09-03-2017 IPR004942 Roadblock/LAMTOR2 domain TK78_RS24290 73710ba30486bd6aacf85f0d3ddb03de 219 Gene3D G3DSA:2.160.10.10 36 213 1.3E-45 T 09-03-2017 TK78_RS24290 73710ba30486bd6aacf85f0d3ddb03de 219 SUPERFAMILY SSF51161 57 210 4.02E-42 T 09-03-2017 IPR011004 Trimeric LpxA-like TK78_RS24290 73710ba30486bd6aacf85f0d3ddb03de 219 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 120 153 2.2E-8 T 09-03-2017 IPR001451 Hexapeptide repeat TK78_RS29855 bf1dfc578c36a35756ca7249b2e6b365 183 SUPERFAMILY SSF46689 4 64 4.94E-12 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS29855 bf1dfc578c36a35756ca7249b2e6b365 183 Pfam PF00440 Bacterial regulatory proteins, tetR family 9 52 2.4E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS29855 bf1dfc578c36a35756ca7249b2e6b365 183 Gene3D G3DSA:1.10.357.10 5 178 3.3E-25 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS29855 bf1dfc578c36a35756ca7249b2e6b365 183 SUPERFAMILY SSF48498 104 163 3.86E-8 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS04860 3f567b2091def25781d743d5c22d37df 308 SUPERFAMILY SSF103481 203 299 3.92E-13 T 09-03-2017 TK78_RS04860 3f567b2091def25781d743d5c22d37df 308 SUPERFAMILY SSF103481 53 153 2.35E-8 T 09-03-2017 TK78_RS04860 3f567b2091def25781d743d5c22d37df 308 Pfam PF00892 EamA-like transporter family 160 298 4.4E-14 T 09-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 TK78_RS04860 3f567b2091def25781d743d5c22d37df 308 Pfam PF00892 EamA-like transporter family 24 149 3.7E-13 T 09-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 TK78_RS01180 14db8b20233a8dacd7bb1a0ed2b2e5f9 400 SUPERFAMILY SSF159501 15 397 2.27E-85 T 09-03-2017 TK78_RS01180 14db8b20233a8dacd7bb1a0ed2b2e5f9 400 Gene3D G3DSA:3.30.1870.10 55 127 3.6E-17 T 09-03-2017 TK78_RS01180 14db8b20233a8dacd7bb1a0ed2b2e5f9 400 PIRSF PIRSF036794 1 399 2.1E-83 T 09-03-2017 IPR014622 Uncharacterised conserved protein UCP036794, erythromycin esterase-type TK78_RS01180 14db8b20233a8dacd7bb1a0ed2b2e5f9 400 Gene3D G3DSA:3.40.1660.10 25 53 2.7E-9 T 09-03-2017 TK78_RS01180 14db8b20233a8dacd7bb1a0ed2b2e5f9 400 Gene3D G3DSA:3.40.1660.10 278 357 2.7E-9 T 09-03-2017 TK78_RS01180 14db8b20233a8dacd7bb1a0ed2b2e5f9 400 Pfam PF05139 Erythromycin esterase 52 397 2.1E-66 T 09-03-2017 IPR007815 Erythromycin esterase GO:0046677 TK78_RS07560 30e8ce1e9ea7e0a8aa80cc7dd266e595 63 Pfam PF05532 CsbD-like 3 51 3.4E-13 T 09-03-2017 IPR008462 CsbD-like TK78_RS07560 30e8ce1e9ea7e0a8aa80cc7dd266e595 63 SUPERFAMILY SSF69047 3 56 3.4E-9 T 09-03-2017 IPR008462 CsbD-like TK78_RS07560 30e8ce1e9ea7e0a8aa80cc7dd266e595 63 Gene3D G3DSA:1.10.1470.10 3 57 6.0E-13 T 09-03-2017 IPR008462 CsbD-like TK78_RS10735 9c852a3a8bb9319d3d461d7d9794d45c 375 Pfam PF01544 CorA-like Mg2+ transporter protein 73 365 4.6E-60 T 09-03-2017 IPR002523 Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB GO:0016020|GO:0030001|GO:0046873|GO:0055085 TK78_RS10735 9c852a3a8bb9319d3d461d7d9794d45c 375 Gene3D G3DSA:1.20.58.340 181 297 3.0E-39 T 09-03-2017 TK78_RS10735 9c852a3a8bb9319d3d461d7d9794d45c 375 Gene3D G3DSA:3.30.460.20 28 180 4.5E-47 T 09-03-2017 TK78_RS10735 9c852a3a8bb9319d3d461d7d9794d45c 375 SUPERFAMILY SSF144083 311 372 2.09E-19 T 09-03-2017 TK78_RS10735 9c852a3a8bb9319d3d461d7d9794d45c 375 Gene3D G3DSA:1.20.58.340 299 375 1.6E-25 T 09-03-2017 TK78_RS10735 9c852a3a8bb9319d3d461d7d9794d45c 375 SUPERFAMILY SSF143865 33 306 8.89E-65 T 09-03-2017 TK78_RS31280 3cd53b86ca6b414f7a42dee0a92b0c25 246 SUPERFAMILY SSF53335 13 245 1.51E-38 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS31280 3cd53b86ca6b414f7a42dee0a92b0c25 246 Pfam PF13649 Methyltransferase domain 44 139 1.8E-18 T 09-03-2017 TK78_RS31280 3cd53b86ca6b414f7a42dee0a92b0c25 246 Gene3D G3DSA:3.40.50.150 198 225 4.7E-36 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS31280 3cd53b86ca6b414f7a42dee0a92b0c25 246 Gene3D G3DSA:3.40.50.150 23 166 4.7E-36 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS10595 9f9342956d2d81575f7b0844ce057115 318 Pfam PF09297 NADH pyrophosphatase zinc ribbon domain 140 170 1.2E-12 T 09-03-2017 IPR015376 Zinc ribbon, NADH pyrophosphatase GO:0016787|GO:0046872 KEGG: 00760+3.6.1.22|MetaCyc: PWY-5381 TK78_RS10595 9f9342956d2d81575f7b0844ce057115 318 Gene3D G3DSA:3.90.79.10 137 305 8.8E-50 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS10595 9f9342956d2d81575f7b0844ce057115 318 SUPERFAMILY SSF55811 123 307 4.74E-49 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS10595 9f9342956d2d81575f7b0844ce057115 318 Pfam PF09296 NADH pyrophosphatase-like rudimentary NUDIX domain 43 137 1.1E-12 T 09-03-2017 IPR015375 NADH pyrophosphatase-like, N-terminal GO:0016787 KEGG: 00760+3.6.1.22|MetaCyc: PWY-5381 TK78_RS10595 9f9342956d2d81575f7b0844ce057115 318 Pfam PF00293 NUDIX domain 174 285 4.7E-19 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS29045 729873c338cd5044d2ef9def46e7c491 212 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 46 69 8.5E-11 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS29045 729873c338cd5044d2ef9def46e7c491 212 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 25 38 8.5E-11 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS29045 729873c338cd5044d2ef9def46e7c491 212 Gene3D G3DSA:1.10.10.60 54 71 6.4E-7 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS29045 729873c338cd5044d2ef9def46e7c491 212 Pfam PF00440 Bacterial regulatory proteins, tetR family 25 70 5.6E-19 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS29045 729873c338cd5044d2ef9def46e7c491 212 Gene3D G3DSA:1.10.10.60 22 53 2.7E-15 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS29045 729873c338cd5044d2ef9def46e7c491 212 SUPERFAMILY SSF46689 16 97 5.82E-18 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS29045 729873c338cd5044d2ef9def46e7c491 212 Gene3D G3DSA:1.10.357.10 72 206 7.2E-33 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS29045 729873c338cd5044d2ef9def46e7c491 212 SUPERFAMILY SSF48498 92 205 4.19E-19 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS01690 38c63be43ac6e92557514a03422dcbaf 500 Gene3D G3DSA:3.40.109.10 368 474 2.6E-6 T 09-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TK78_RS01690 38c63be43ac6e92557514a03422dcbaf 500 SUPERFAMILY SSF55469 367 467 4.57E-7 T 09-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TK78_RS09035 a998f52cb14761aaf9e80ccceb86d557 86 Gene3D G3DSA:1.10.1200.10 3 79 3.2E-17 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS09035 a998f52cb14761aaf9e80ccceb86d557 86 Pfam PF00550 Phosphopantetheine attachment site 9 77 2.9E-9 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS09035 a998f52cb14761aaf9e80ccceb86d557 86 SUPERFAMILY SSF47336 3 79 6.28E-15 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS06175 d6c10c3e1b3fe8339d7d4d0909c5139d 949 Gene3D G3DSA:3.40.50.10140 4 91 7.1E-7 T 09-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 TK78_RS06175 d6c10c3e1b3fe8339d7d4d0909c5139d 949 SUPERFAMILY SSF50998 796 899 8.63E-9 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS06175 d6c10c3e1b3fe8339d7d4d0909c5139d 949 Gene3D G3DSA:2.130.10.10 293 527 2.5E-19 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS06175 d6c10c3e1b3fe8339d7d4d0909c5139d 949 Pfam PF13676 TIR domain 6 109 2.2E-9 T 09-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 TK78_RS06175 d6c10c3e1b3fe8339d7d4d0909c5139d 949 SUPERFAMILY SSF52200 3 104 6.15E-10 T 09-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 TK78_RS06175 d6c10c3e1b3fe8339d7d4d0909c5139d 949 SUPERFAMILY SSF50998 721 822 5.1E-29 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS06175 d6c10c3e1b3fe8339d7d4d0909c5139d 949 SUPERFAMILY SSF50998 473 596 5.1E-29 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS06175 d6c10c3e1b3fe8339d7d4d0909c5139d 949 SUPERFAMILY SSF50998 306 438 5.1E-29 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS06175 d6c10c3e1b3fe8339d7d4d0909c5139d 949 SUPERFAMILY SSF50998 648 684 5.1E-29 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS06175 d6c10c3e1b3fe8339d7d4d0909c5139d 949 SMART SM00255 2 147 4.9E-4 T 09-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 TK78_RS06175 d6c10c3e1b3fe8339d7d4d0909c5139d 949 SMART SM00320 555 594 0.0021 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS06175 d6c10c3e1b3fe8339d7d4d0909c5139d 949 SMART SM00320 474 514 250.0 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS06175 d6c10c3e1b3fe8339d7d4d0909c5139d 949 SMART SM00320 774 817 120.0 T 09-03-2017 IPR001680 WD40 repeat GO:0005515 TK78_RS06175 d6c10c3e1b3fe8339d7d4d0909c5139d 949 Gene3D G3DSA:2.130.10.10 541 774 3.7E-18 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS06175 d6c10c3e1b3fe8339d7d4d0909c5139d 949 Gene3D G3DSA:2.130.10.10 795 900 3.8E-9 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS24880 423c1adc47c351e043f97c4b742fbd38 248 SUPERFAMILY SSF57863 88 238 8.37E-39 T 09-03-2017 TK78_RS24880 423c1adc47c351e043f97c4b742fbd38 248 Pfam PF11967 Recombination protein O N terminal 1 85 1.5E-28 T 09-03-2017 IPR022572 DNA replication/recombination mediator RecO, N-terminal TK78_RS24880 423c1adc47c351e043f97c4b742fbd38 248 Pfam PF02565 Recombination protein O C terminal 92 244 1.3E-33 T 09-03-2017 IPR003717 Recombination protein O, RecO GO:0006281|GO:0006310 TK78_RS24880 423c1adc47c351e043f97c4b742fbd38 248 Hamap MF_00201 DNA repair protein RecO [recO]. 2 248 26.064 T 09-03-2017 IPR003717 Recombination protein O, RecO GO:0006281|GO:0006310 TK78_RS24880 423c1adc47c351e043f97c4b742fbd38 248 Gene3D G3DSA:2.40.50.140 1 86 9.7E-35 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS24880 423c1adc47c351e043f97c4b742fbd38 248 SUPERFAMILY SSF50249 1 85 7.37E-19 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS24880 423c1adc47c351e043f97c4b742fbd38 248 TIGRFAM TIGR00613 reco: DNA repair protein RecO 5 240 5.9E-36 T 09-03-2017 IPR003717 Recombination protein O, RecO GO:0006281|GO:0006310 TK78_RS25055 34a74fc7a5688b0fdf597ab2663ac8cc 259 Pfam PF00561 alpha/beta hydrolase fold 26 128 4.8E-18 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS25055 34a74fc7a5688b0fdf597ab2663ac8cc 259 PRINTS PR00111 Alpha/beta hydrolase fold signature 95 108 1.2E-8 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS25055 34a74fc7a5688b0fdf597ab2663ac8cc 259 PRINTS PR00111 Alpha/beta hydrolase fold signature 109 122 1.2E-8 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS25055 34a74fc7a5688b0fdf597ab2663ac8cc 259 PRINTS PR00111 Alpha/beta hydrolase fold signature 50 65 1.2E-8 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS25055 34a74fc7a5688b0fdf597ab2663ac8cc 259 SUPERFAMILY SSF53474 4 252 2.54E-38 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS25055 34a74fc7a5688b0fdf597ab2663ac8cc 259 Gene3D G3DSA:3.40.50.1820 4 255 4.3E-36 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS33025 0ecf4eed8e5a8bba34ec7ec22a498879 632 Gene3D G3DSA:1.20.1560.10 30 350 7.2E-73 T 09-03-2017 TK78_RS33025 0ecf4eed8e5a8bba34ec7ec22a498879 632 Pfam PF00005 ABC transporter 397 546 4.0E-31 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS33025 0ecf4eed8e5a8bba34ec7ec22a498879 632 SMART SM00382 406 592 5.0E-17 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS33025 0ecf4eed8e5a8bba34ec7ec22a498879 632 SUPERFAMILY SSF52540 359 617 4.79E-82 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33025 0ecf4eed8e5a8bba34ec7ec22a498879 632 SUPERFAMILY SSF90123 30 350 2.35E-73 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS33025 0ecf4eed8e5a8bba34ec7ec22a498879 632 Gene3D G3DSA:3.40.50.300 362 610 2.4E-74 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33025 0ecf4eed8e5a8bba34ec7ec22a498879 632 ProSitePatterns PS00211 ABC transporters family signature. 518 532 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS33025 0ecf4eed8e5a8bba34ec7ec22a498879 632 Pfam PF00664 ABC transporter transmembrane region 47 314 1.5E-42 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS17290 b27bcdfb3bcb4bf4c36f0de07e69dbae 727 PRINTS PR01806 Virulence factor MviN signature 240 256 1.2E-19 T 09-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ TK78_RS17290 b27bcdfb3bcb4bf4c36f0de07e69dbae 727 PRINTS PR01806 Virulence factor MviN signature 221 240 1.2E-19 T 09-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ TK78_RS17290 b27bcdfb3bcb4bf4c36f0de07e69dbae 727 PRINTS PR01806 Virulence factor MviN signature 344 365 1.2E-19 T 09-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ TK78_RS17290 b27bcdfb3bcb4bf4c36f0de07e69dbae 727 PRINTS PR01806 Virulence factor MviN signature 618 635 1.2E-19 T 09-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ TK78_RS17290 b27bcdfb3bcb4bf4c36f0de07e69dbae 727 PRINTS PR01806 Virulence factor MviN signature 562 581 1.2E-19 T 09-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ TK78_RS17290 b27bcdfb3bcb4bf4c36f0de07e69dbae 727 PRINTS PR01806 Virulence factor MviN signature 320 344 1.2E-19 T 09-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ TK78_RS17290 b27bcdfb3bcb4bf4c36f0de07e69dbae 727 Pfam PF03023 MviN-like protein 217 690 1.1E-125 T 09-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ TK78_RS17290 b27bcdfb3bcb4bf4c36f0de07e69dbae 727 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 680 708 - T 09-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 TK78_RS17290 b27bcdfb3bcb4bf4c36f0de07e69dbae 727 TIGRFAM TIGR01695 murJ_mviN: murein biosynthesis integral membrane protein MurJ 191 718 1.4E-147 T 09-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ TK78_RS19760 9b8bb786dd996a5dd6cb0b7935382760 350 Pfam PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 88 175 3.9E-23 T 09-03-2017 IPR022412 Quinolinate phosphoribosyl transferase, N-terminal GO:0016763 Reactome: R-HSA-196807 TK78_RS19760 9b8bb786dd996a5dd6cb0b7935382760 350 Pfam PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 177 341 8.6E-56 T 09-03-2017 IPR002638 Quinolinate phosphoribosyl transferase, C-terminal GO:0004514|GO:0009435 KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381 TK78_RS19760 9b8bb786dd996a5dd6cb0b7935382760 350 Gene3D G3DSA:3.20.20.70 198 332 3.7E-57 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS19760 9b8bb786dd996a5dd6cb0b7935382760 350 Gene3D G3DSA:3.90.1170.20 67 197 4.0E-43 T 09-03-2017 IPR022412 Quinolinate phosphoribosyl transferase, N-terminal GO:0016763 Reactome: R-HSA-196807 TK78_RS19760 9b8bb786dd996a5dd6cb0b7935382760 350 SUPERFAMILY SSF54675 69 176 4.71E-26 T 09-03-2017 TK78_RS19760 9b8bb786dd996a5dd6cb0b7935382760 350 SUPERFAMILY SSF51690 177 342 2.51E-56 T 09-03-2017 IPR002638 Quinolinate phosphoribosyl transferase, C-terminal GO:0004514|GO:0009435 KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381 TK78_RS19760 9b8bb786dd996a5dd6cb0b7935382760 350 TIGRFAM TIGR00078 nadC: nicotinate-nucleotide diphosphorylase (carboxylating) 79 342 1.6E-90 T 09-03-2017 IPR004393 Nicotinate-nucleotide pyrophosphorylase GO:0004514|GO:0019363 KEGG: 00760+2.4.2.19|MetaCyc: PWY-5316|MetaCyc: PWY-5653|MetaCyc: PWY-7342|Reactome: R-HSA-196807 TK78_RS25590 c24e964c4b8894c98b75b057cc7ae03e 134 Pfam PF03995 Peptidase inhibitor family I36 44 107 3.0E-13 T 09-03-2017 TK78_RS07860 6338fcbbe704f26bd915e82e2584889c 188 Pfam PF00583 Acetyltransferase (GNAT) family 67 160 9.1E-9 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS07860 6338fcbbe704f26bd915e82e2584889c 188 SUPERFAMILY SSF55729 24 180 9.24E-16 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS07860 6338fcbbe704f26bd915e82e2584889c 188 Gene3D G3DSA:3.40.630.30 25 165 5.7E-16 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS30905 497bb6a9b6cfd5dca2b5db04ea3264d4 201 Pfam PF03551 Transcriptional regulator PadR-like family 66 134 1.7E-20 T 09-03-2017 IPR005149 Transcription regulator PadR, N-terminal TK78_RS30905 497bb6a9b6cfd5dca2b5db04ea3264d4 201 Gene3D G3DSA:1.10.10.10 55 138 5.8E-28 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS30905 497bb6a9b6cfd5dca2b5db04ea3264d4 201 SUPERFAMILY SSF46785 53 145 9.29E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS33865 dbbb09c3c1e0988a807e83f68699c241 71 Gene3D G3DSA:3.90.820.10 13 62 6.1E-21 T 09-03-2017 TK78_RS33865 dbbb09c3c1e0988a807e83f68699c241 71 SUPERFAMILY SSF160582 7 62 2.75E-19 T 09-03-2017 TK78_RS33865 dbbb09c3c1e0988a807e83f68699c241 71 SMART SM00923 7 56 2.8E-23 T 09-03-2017 IPR005153 MbtH-like protein TK78_RS33865 dbbb09c3c1e0988a807e83f68699c241 71 Pfam PF03621 MbtH-like protein 6 55 4.4E-22 T 09-03-2017 IPR005153 MbtH-like protein TK78_RS27940 47d1f3049e1a34c8f83fb43fd8c11684 695 TIGRFAM TIGR00232 tktlase_bact: transketolase 19 688 6.9E-239 T 09-03-2017 IPR005478 Transketolase, bacterial-like GO:0004802 KEGG: 00030+2.2.1.1|KEGG: 00710+2.2.1.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723|MetaCyc: PWY-6901 TK78_RS27940 47d1f3049e1a34c8f83fb43fd8c11684 695 Pfam PF02780 Transketolase, C-terminal domain 576 682 3.4E-12 T 09-03-2017 IPR033248 Transketolase, C-terminal domain TK78_RS27940 47d1f3049e1a34c8f83fb43fd8c11684 695 SMART SM00861 371 555 1.7E-65 T 09-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain TK78_RS27940 47d1f3049e1a34c8f83fb43fd8c11684 695 ProSitePatterns PS00802 Transketolase signature 2. 491 507 - T 09-03-2017 IPR020826 Transketolase binding site KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 TK78_RS27940 47d1f3049e1a34c8f83fb43fd8c11684 695 SUPERFAMILY SSF52922 560 691 3.66E-41 T 09-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 TK78_RS27940 47d1f3049e1a34c8f83fb43fd8c11684 695 Pfam PF00456 Transketolase, thiamine diphosphate binding domain 16 355 1.3E-137 T 09-03-2017 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 TK78_RS27940 47d1f3049e1a34c8f83fb43fd8c11684 695 Pfam PF02779 Transketolase, pyrimidine binding domain 370 534 7.0E-44 T 09-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain TK78_RS27940 47d1f3049e1a34c8f83fb43fd8c11684 695 SUPERFAMILY SSF52518 358 556 3.07E-64 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS27940 47d1f3049e1a34c8f83fb43fd8c11684 695 SUPERFAMILY SSF52518 7 341 2.0E-105 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS27940 47d1f3049e1a34c8f83fb43fd8c11684 695 ProSitePatterns PS00801 Transketolase signature 1. 24 44 - T 09-03-2017 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 TK78_RS27940 47d1f3049e1a34c8f83fb43fd8c11684 695 Gene3D G3DSA:3.40.50.920 565 691 1.1E-48 T 09-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 TK78_RS27940 47d1f3049e1a34c8f83fb43fd8c11684 695 Gene3D G3DSA:3.40.50.970 351 564 9.5E-74 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS27940 47d1f3049e1a34c8f83fb43fd8c11684 695 Gene3D G3DSA:3.40.50.970 11 341 7.2E-112 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS10890 b0373f6e29649e130300d0a05a42589e 417 Gene3D G3DSA:1.20.1250.20 5 195 1.5E-10 T 09-03-2017 TK78_RS10890 b0373f6e29649e130300d0a05a42589e 417 SUPERFAMILY SSF103473 14 380 1.57E-24 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS06090 232dffb909d9418235a5a6cf826ef873 509 SUPERFAMILY SSF55205 74 506 9.65E-94 T 09-03-2017 IPR013792 RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta GO:0003824 TK78_RS06090 232dffb909d9418235a5a6cf826ef873 509 Gene3D G3DSA:3.65.10.10 293 504 2.9E-38 T 09-03-2017 IPR001986 Enolpyruvate transferase domain GO:0016765 TK78_RS06090 232dffb909d9418235a5a6cf826ef873 509 Pfam PF00275 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) 79 496 1.0E-39 T 09-03-2017 IPR001986 Enolpyruvate transferase domain GO:0016765 TK78_RS06090 232dffb909d9418235a5a6cf826ef873 509 SUPERFAMILY SSF47413 4 65 7.51E-16 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS06090 232dffb909d9418235a5a6cf826ef873 509 Gene3D G3DSA:1.10.260.40 3 66 1.8E-20 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS06090 232dffb909d9418235a5a6cf826ef873 509 Gene3D G3DSA:3.65.10.10 92 292 1.5E-39 T 09-03-2017 IPR001986 Enolpyruvate transferase domain GO:0016765 TK78_RS06090 232dffb909d9418235a5a6cf826ef873 509 SMART SM00530 12 67 1.2E-14 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS06090 232dffb909d9418235a5a6cf826ef873 509 Pfam PF01381 Helix-turn-helix 13 63 2.9E-14 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS12360 5f74a98e328c63e03497cabff434f74f 255 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 167 178 - T 09-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TK78_RS12360 5f74a98e328c63e03497cabff434f74f 255 Pfam PF13183 4Fe-4S dicluster domain 165 237 1.1E-11 T 09-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TK78_RS12360 5f74a98e328c63e03497cabff434f74f 255 SUPERFAMILY SSF46548 126 251 1.29E-33 T 09-03-2017 IPR009051 Alpha-helical ferredoxin GO:0051536 TK78_RS12360 5f74a98e328c63e03497cabff434f74f 255 Gene3D G3DSA:1.10.1060.10 126 253 3.5E-40 T 09-03-2017 TK78_RS12360 5f74a98e328c63e03497cabff434f74f 255 Pfam PF13085 2Fe-2S iron-sulfur cluster binding domain 25 130 7.1E-36 T 09-03-2017 IPR025192 Succinate dehydogenase/fumarate reductase N-terminal GO:0009055|GO:0051536 KEGG: 00020+1.3.5.1|KEGG: 00190+1.3.5.1|KEGG: 00650+1.3.5.1|KEGG: 00720+1.3.5.1|MetaCyc: PWY-3781|MetaCyc: PWY-4302|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7279|Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS12360 5f74a98e328c63e03497cabff434f74f 255 Gene3D G3DSA:3.10.20.30 23 125 1.1E-38 T 09-03-2017 IPR012675 Beta-grasp domain TK78_RS12360 5f74a98e328c63e03497cabff434f74f 255 SUPERFAMILY SSF54292 22 125 4.3E-28 T 09-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 TK78_RS12360 5f74a98e328c63e03497cabff434f74f 255 TIGRFAM TIGR00384 dhsB: succinate dehydrogenase and fumarate reductase iron-sulfur protein 28 247 1.5E-80 T 09-03-2017 IPR004489 Succinate dehydrogenase/fumarate reductase iron-sulphur protein GO:0006099|GO:0016491|GO:0055114 KEGG: 00020+1.3.5.1|KEGG: 00190+1.3.5.1|KEGG: 00650+1.3.5.1|KEGG: 00720+1.3.5.1|MetaCyc: PWY-3781|MetaCyc: PWY-4302|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7279|Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS26665 eb3bbfb40411f3d4315a1d207d17366e 400 SUPERFAMILY SSF56281 2 184 5.68E-8 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS26665 eb3bbfb40411f3d4315a1d207d17366e 400 Gene3D G3DSA:3.40.50.300 225 398 5.1E-55 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS26665 eb3bbfb40411f3d4315a1d207d17366e 400 SUPERFAMILY SSF52540 225 398 3.98E-39 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS26665 eb3bbfb40411f3d4315a1d207d17366e 400 Pfam PF02283 Cobinamide kinase / cobinamide phosphate guanyltransferase 225 396 3.1E-52 T 09-03-2017 IPR003203 Cobinamide kinase/cobinamide phosphate guanyltransferase GO:0000166|GO:0009236|GO:0043752|GO:0051188 KEGG: 00030+2.7.1.15|KEGG: 00860+2.7.7.62+2.7.1.156|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 TK78_RS26665 eb3bbfb40411f3d4315a1d207d17366e 400 Gene3D G3DSA:3.60.15.10 2 75 1.2E-10 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS20550 fc5fa80131b8b2273c5383928d277f66 1471 SUPERFAMILY SSF50494 14 208 2.31E-20 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS20550 fc5fa80131b8b2273c5383928d277f66 1471 Pfam PF13365 Trypsin-like peptidase domain 30 185 7.9E-18 T 09-03-2017 TK78_RS20550 fc5fa80131b8b2273c5383928d277f66 1471 Gene3D G3DSA:2.130.10.10 1110 1247 4.9E-6 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS20550 fc5fa80131b8b2273c5383928d277f66 1471 Gene3D G3DSA:2.130.10.10 976 1030 4.9E-6 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS20550 fc5fa80131b8b2273c5383928d277f66 1471 Gene3D G3DSA:2.130.10.10 1307 1411 4.9E-6 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS20550 fc5fa80131b8b2273c5383928d277f66 1471 Gene3D G3DSA:3.40.50.300 230 380 9.7E-9 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS20550 fc5fa80131b8b2273c5383928d277f66 1471 Gene3D G3DSA:2.40.10.10 17 100 5.9E-6 T 09-03-2017 TK78_RS20550 fc5fa80131b8b2273c5383928d277f66 1471 SUPERFAMILY SSF69322 747 1029 1.44E-19 T 09-03-2017 TK78_RS20550 fc5fa80131b8b2273c5383928d277f66 1471 SUPERFAMILY SSF52540 235 484 4.49E-13 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS20550 fc5fa80131b8b2273c5383928d277f66 1471 SUPERFAMILY SSF50998 1073 1412 4.71E-10 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS20550 fc5fa80131b8b2273c5383928d277f66 1471 Gene3D G3DSA:2.120.10.60 755 975 7.9E-13 T 09-03-2017 TK78_RS20550 fc5fa80131b8b2273c5383928d277f66 1471 Gene3D G3DSA:2.40.10.10 101 205 2.1E-7 T 09-03-2017 TK78_RS24500 54e943198a28be8924ecf95cc29cdb92 339 SUPERFAMILY SSF55347 124 242 3.92E-18 T 09-03-2017 TK78_RS24500 54e943198a28be8924ecf95cc29cdb92 339 Gene3D G3DSA:3.40.50.720 5 132 3.8E-28 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS24500 54e943198a28be8924ecf95cc29cdb92 339 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 6 119 3.7E-19 T 09-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 TK78_RS24500 54e943198a28be8924ecf95cc29cdb92 339 SUPERFAMILY SSF51735 5 145 8.69E-34 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS24500 54e943198a28be8924ecf95cc29cdb92 339 Gene3D G3DSA:3.30.360.10 133 241 9.6E-26 T 09-03-2017 TK78_RS24500 54e943198a28be8924ecf95cc29cdb92 339 Gene3D G3DSA:3.30.360.10 276 330 9.6E-26 T 09-03-2017 TK78_RS30555 68c90fd01339a9c47dc4c00a17382df0 146 Pfam PF01037 Lrp/AsnC ligand binding domain 67 137 2.6E-14 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS30555 68c90fd01339a9c47dc4c00a17382df0 146 SUPERFAMILY SSF46785 1 60 1.28E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS30555 68c90fd01339a9c47dc4c00a17382df0 146 Pfam PF13404 AsnC-type helix-turn-helix domain 1 42 8.9E-17 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS30555 68c90fd01339a9c47dc4c00a17382df0 146 Gene3D G3DSA:1.10.10.10 3 53 8.5E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS30555 68c90fd01339a9c47dc4c00a17382df0 146 SUPERFAMILY SSF54909 61 144 5.5E-15 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS30555 68c90fd01339a9c47dc4c00a17382df0 146 Gene3D G3DSA:3.30.70.920 54 133 1.0E-23 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS30555 68c90fd01339a9c47dc4c00a17382df0 146 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 28 47 4.4E-16 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS30555 68c90fd01339a9c47dc4c00a17382df0 146 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 1 17 4.4E-16 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS30555 68c90fd01339a9c47dc4c00a17382df0 146 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 17 28 4.4E-16 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS30555 68c90fd01339a9c47dc4c00a17382df0 146 SMART SM00344 1 108 1.1E-44 T 09-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 TK78_RS30555 68c90fd01339a9c47dc4c00a17382df0 146 ProSitePatterns PS00519 AsnC-type HTH domain signature. 19 45 - T 09-03-2017 IPR019885 Transcription regulator HTH, AsnC-type, conserved site TK78_RS05460 2123f04705ca119491e15029f73f5f72 432 Gene3D G3DSA:1.10.10.10 334 391 1.2E-4 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05460 2123f04705ca119491e15029f73f5f72 432 Pfam PF01590 GAF domain 104 219 1.2E-8 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS13945 9bc76fd646e2d47916ae603ec12faa9c 133 Pfam PF10990 Protein of unknown function (DUF2809) 25 107 1.2E-22 T 09-03-2017 IPR021257 Protein of unknown function DUF2809 TK78_RS24875 d4f293f9d2bbca95b35f1fe18257c559 236 SUPERFAMILY SSF51182 9 188 2.0E-17 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS24875 d4f293f9d2bbca95b35f1fe18257c559 236 Gene3D G3DSA:2.60.120.10 10 71 8.8E-10 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS24875 d4f293f9d2bbca95b35f1fe18257c559 236 Pfam PF07883 Cupin domain 10 71 7.0E-9 T 09-03-2017 IPR013096 Cupin 2, conserved barrel TK78_RS24875 d4f293f9d2bbca95b35f1fe18257c559 236 Pfam PF12833 Helix-turn-helix domain 159 235 1.7E-17 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS24875 d4f293f9d2bbca95b35f1fe18257c559 236 Gene3D G3DSA:1.10.10.60 191 235 6.7E-8 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS24875 d4f293f9d2bbca95b35f1fe18257c559 236 SUPERFAMILY SSF46689 190 235 2.96E-7 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS24875 d4f293f9d2bbca95b35f1fe18257c559 236 Gene3D G3DSA:1.10.10.60 132 190 3.2E-10 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS24875 d4f293f9d2bbca95b35f1fe18257c559 236 SMART SM00342 153 235 5.3E-22 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS19540 171398d60487e562e385b0380292eb4a 342 SUPERFAMILY SSF46689 237 283 3.41E-9 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS19540 171398d60487e562e385b0380292eb4a 342 SMART SM00342 249 332 1.9E-29 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS19540 171398d60487e562e385b0380292eb4a 342 Gene3D G3DSA:1.10.10.60 287 334 2.5E-11 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS19540 171398d60487e562e385b0380292eb4a 342 SUPERFAMILY SSF52317 19 215 7.85E-39 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS19540 171398d60487e562e385b0380292eb4a 342 Pfam PF12833 Helix-turn-helix domain 255 333 1.8E-22 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS19540 171398d60487e562e385b0380292eb4a 342 SUPERFAMILY SSF46689 286 336 1.22E-9 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS19540 171398d60487e562e385b0380292eb4a 342 Gene3D G3DSA:1.10.10.60 236 286 2.1E-14 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS19540 171398d60487e562e385b0380292eb4a 342 Gene3D G3DSA:3.40.50.880 21 231 2.8E-40 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS19540 171398d60487e562e385b0380292eb4a 342 Pfam PF01965 DJ-1/PfpI family 119 193 2.6E-8 T 09-03-2017 IPR002818 DJ-1/PfpI TK78_RS23370 b7eb46f3ad814d3dc42e1d0f2d6b1f95 173 SUPERFAMILY SSF52402 40 173 3.1E-21 T 09-03-2017 TK78_RS23370 b7eb46f3ad814d3dc42e1d0f2d6b1f95 173 Pfam PF00582 Universal stress protein family 40 173 1.0E-22 T 09-03-2017 IPR006016 UspA GO:0006950 TK78_RS23370 b7eb46f3ad814d3dc42e1d0f2d6b1f95 173 Gene3D G3DSA:3.40.50.620 39 173 4.8E-32 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS23370 b7eb46f3ad814d3dc42e1d0f2d6b1f95 173 PRINTS PR01438 Universal stress protein signature 151 173 1.5E-6 T 09-03-2017 IPR006015 Universal stress protein A TK78_RS23370 b7eb46f3ad814d3dc42e1d0f2d6b1f95 173 PRINTS PR01438 Universal stress protein signature 37 55 1.5E-6 T 09-03-2017 IPR006015 Universal stress protein A TK78_RS11220 ff66cf4f05e8f6ad18e448d3ac671e15 173 SMART SM00347 52 155 5.8E-13 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS11220 ff66cf4f05e8f6ad18e448d3ac671e15 173 SUPERFAMILY SSF46785 20 166 2.05E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS11220 ff66cf4f05e8f6ad18e448d3ac671e15 173 Gene3D G3DSA:1.10.10.10 21 166 9.6E-31 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS11220 ff66cf4f05e8f6ad18e448d3ac671e15 173 Pfam PF12802 MarR family 57 117 6.2E-11 T 09-03-2017 TK78_RS00605 d46990f526d772541036778e25523c84 286 Gene3D G3DSA:1.10.260.40 3 80 2.0E-20 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS00605 d46990f526d772541036778e25523c84 286 Pfam PF13560 Helix-turn-helix domain 5 84 4.0E-19 T 09-03-2017 TK78_RS00605 d46990f526d772541036778e25523c84 286 SUPERFAMILY SSF47413 29 80 4.74E-9 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS00605 d46990f526d772541036778e25523c84 286 SMART SM00530 9 81 6.6E-9 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS06350 4678294e86abe57a8fa01ab7e283ff0b 208 Pfam PF01899 Na+/H+ ion antiporter subunit 34 180 3.9E-29 T 09-03-2017 IPR002758 Na+/H+ antiporter subunit E GO:0006812|GO:0008324|GO:0016021 TK78_RS12410 f5b63a3d9f421587f3aa68c88472882b 325 Pfam PF03631 Virulence factor BrkB 33 281 2.1E-45 T 09-03-2017 IPR017039 Virulence factor BrkB TK78_RS12410 f5b63a3d9f421587f3aa68c88472882b 325 PIRSF PIRSF035875 12 305 8.0E-27 T 09-03-2017 IPR017039 Virulence factor BrkB TK78_RS11790 f122999fe92f75846624f475ea9e9ce3 578 Pfam PF01425 Amidase 470 553 2.2E-5 T 09-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 TK78_RS11790 f122999fe92f75846624f475ea9e9ce3 578 Pfam PF01425 Amidase 28 252 3.5E-41 T 09-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 TK78_RS11790 f122999fe92f75846624f475ea9e9ce3 578 SUPERFAMILY SSF75304 6 354 7.19E-80 T 09-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 TK78_RS11790 f122999fe92f75846624f475ea9e9ce3 578 SUPERFAMILY SSF75304 387 570 7.19E-80 T 09-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 TK78_RS11790 f122999fe92f75846624f475ea9e9ce3 578 Gene3D G3DSA:3.90.1300.10 5 573 1.2E-108 T 09-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 TK78_RS13600 3170cb52c67549b078bfdd8239132d43 539 TIGRFAM TIGR01770 NDH_I_N: proton-translocating NADH-quinone oxidoreductase, chain N 145 527 7.0E-115 T 09-03-2017 IPR010096 NAD(P)H-quinone oxidoreductase, subunit N/subunit 2 GO:0008137|GO:0042773|GO:0055114 TK78_RS13600 3170cb52c67549b078bfdd8239132d43 539 Pfam PF00361 Proton-conducting membrane transporter 169 474 3.8E-74 T 09-03-2017 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13600 3170cb52c67549b078bfdd8239132d43 539 Hamap MF_00445 NAD(P)H-quinone oxidoreductase subunit 2, chloroplastic [ndhB]. 15 528 18.014 T 09-03-2017 IPR010096 NAD(P)H-quinone oxidoreductase, subunit N/subunit 2 GO:0008137|GO:0042773|GO:0055114 TK78_RS13565 ae03c065d165dc53fd1a5078e34aa595 409 TIGRFAM TIGR01266 fum_ac_acetase: fumarylacetoacetase 9 408 9.8E-126 T 09-03-2017 IPR005959 Fumarylacetoacetase GO:0004334|GO:0009072 KEGG: 00350+3.7.1.2|KEGG: 00643+3.7.1.2|Reactome: R-HSA-71182 TK78_RS13565 ae03c065d165dc53fd1a5078e34aa595 409 SUPERFAMILY SSF56529 116 407 2.22E-86 T 09-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 TK78_RS13565 ae03c065d165dc53fd1a5078e34aa595 409 SUPERFAMILY SSF63433 6 114 2.35E-25 T 09-03-2017 IPR015377 Fumarylacetoacetase, N-terminal GO:0004334|GO:0009072 KEGG: 00350+3.7.1.2|KEGG: 00643+3.7.1.2|Reactome: R-HSA-71182 TK78_RS13565 ae03c065d165dc53fd1a5078e34aa595 409 Gene3D G3DSA:3.90.850.10 117 401 1.0E-104 T 09-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 TK78_RS13565 ae03c065d165dc53fd1a5078e34aa595 409 Pfam PF01557 Fumarylacetoacetate (FAA) hydrolase family 120 405 1.2E-51 T 09-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 TK78_RS13565 ae03c065d165dc53fd1a5078e34aa595 409 Gene3D G3DSA:2.30.30.230 8 116 3.9E-28 T 09-03-2017 IPR015377 Fumarylacetoacetase, N-terminal GO:0004334|GO:0009072 KEGG: 00350+3.7.1.2|KEGG: 00643+3.7.1.2|Reactome: R-HSA-71182 TK78_RS13565 ae03c065d165dc53fd1a5078e34aa595 409 Pfam PF09298 Fumarylacetoacetase N-terminal 19 114 1.1E-18 T 09-03-2017 IPR015377 Fumarylacetoacetase, N-terminal GO:0004334|GO:0009072 KEGG: 00350+3.7.1.2|KEGG: 00643+3.7.1.2|Reactome: R-HSA-71182 TK78_RS06985 d23ac6484cc1255187ab3db9cd755b77 396 Gene3D G3DSA:3.40.640.10 30 254 7.9E-68 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS06985 d23ac6484cc1255187ab3db9cd755b77 396 Pfam PF01041 DegT/DnrJ/EryC1/StrS aminotransferase family 32 379 1.2E-97 T 09-03-2017 IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase TK78_RS06985 d23ac6484cc1255187ab3db9cd755b77 396 SUPERFAMILY SSF53383 20 384 3.58E-90 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS06985 d23ac6484cc1255187ab3db9cd755b77 396 Gene3D G3DSA:3.90.1150.10 264 385 2.0E-21 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS06985 d23ac6484cc1255187ab3db9cd755b77 396 PIRSF PIRSF000390 13 388 3.5E-102 T 09-03-2017 IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase TK78_RS03980 2f54f6bc6b605b52daced0f4cae93d18 352 Pfam PF13593 SBF-like CPA transporter family (DUF4137) 16 320 6.7E-88 T 09-03-2017 IPR016833 Putative sodium bile acid cotransporter TK78_RS03980 2f54f6bc6b605b52daced0f4cae93d18 352 PIRSF PIRSF026166 4 337 3.5E-123 T 09-03-2017 IPR016833 Putative sodium bile acid cotransporter TK78_RS07810 f12cd97eb5c97471fd346e335f6ca866 158 Pfam PF02033 Ribosome-binding factor A 6 109 1.1E-24 T 09-03-2017 IPR000238 Ribosome-binding factor A GO:0006364 TK78_RS07810 f12cd97eb5c97471fd346e335f6ca866 158 ProDom PD007327 FACTOR A RIBOSOME-BINDING PROCESSING RRNA 3D-STRUCTURE RIBOSOMAL-BINDING PRECURSOR A RBFA 10 96 3.0E-25 T 09-03-2017 IPR000238 Ribosome-binding factor A GO:0006364 TK78_RS07810 f12cd97eb5c97471fd346e335f6ca866 158 Gene3D G3DSA:3.30.300.20 3 117 7.4E-37 T 09-03-2017 IPR015946 K homology domain-like, alpha/beta TK78_RS07810 f12cd97eb5c97471fd346e335f6ca866 158 SUPERFAMILY SSF89919 3 112 1.44E-30 T 09-03-2017 IPR023799 Ribosome-binding factor A domain TK78_RS07810 f12cd97eb5c97471fd346e335f6ca866 158 ProSitePatterns PS01319 Ribosome-binding factor A signature. 75 96 - T 09-03-2017 IPR020053 Ribosome-binding factor A, conserved site GO:0006364 TK78_RS07810 f12cd97eb5c97471fd346e335f6ca866 158 Hamap MF_00003 Ribosome-binding factor A [rbfA]. 2 116 19.499 T 09-03-2017 IPR000238 Ribosome-binding factor A GO:0006364 TK78_RS07810 f12cd97eb5c97471fd346e335f6ca866 158 TIGRFAM TIGR00082 rbfA: ribosome-binding factor A 5 111 9.6E-23 T 09-03-2017 IPR000238 Ribosome-binding factor A GO:0006364 TK78_RS23625 c9f60d34bf6dceae4ca24881973fd760 197 SUPERFAMILY SSF53597 2 193 5.5E-25 T 09-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 TK78_RS23625 c9f60d34bf6dceae4ca24881973fd760 197 Pfam PF01872 RibD C-terminal domain 3 190 2.9E-9 T 09-03-2017 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 TK78_RS23625 c9f60d34bf6dceae4ca24881973fd760 197 Gene3D G3DSA:3.40.430.10 3 193 2.1E-26 T 09-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 TK78_RS12055 bf0bc01439198fe2a1241fca6b43df09 478 Gene3D G3DSA:3.40.605.10 22 271 2.9E-100 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS12055 bf0bc01439198fe2a1241fca6b43df09 478 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 285 296 - T 09-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 TK78_RS12055 bf0bc01439198fe2a1241fca6b43df09 478 Gene3D G3DSA:3.40.309.10 272 456 1.5E-64 T 09-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 TK78_RS12055 bf0bc01439198fe2a1241fca6b43df09 478 Pfam PF00171 Aldehyde dehydrogenase family 33 477 5.9E-167 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS12055 bf0bc01439198fe2a1241fca6b43df09 478 SUPERFAMILY SSF53720 20 477 8.25E-165 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS28755 acc4f78ecc05966de2459de82b54a3a3 427 Pfam PF00534 Glycosyl transferases group 1 200 359 7.6E-34 T 09-03-2017 IPR001296 Glycosyl transferase, family 1 TK78_RS28755 acc4f78ecc05966de2459de82b54a3a3 427 Pfam PF13439 Glycosyltransferase Family 4 13 191 2.8E-9 T 09-03-2017 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 TK78_RS28755 acc4f78ecc05966de2459de82b54a3a3 427 Gene3D G3DSA:3.40.50.2000 199 360 8.5E-21 T 09-03-2017 TK78_RS28755 acc4f78ecc05966de2459de82b54a3a3 427 SUPERFAMILY SSF53756 5 381 1.7E-64 T 09-03-2017 TK78_RS20610 368addc38c6aacb9d235082192954a33 798 SMART SM00028 546 579 21.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS20610 368addc38c6aacb9d235082192954a33 798 SMART SM00028 750 783 1.8E-5 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS20610 368addc38c6aacb9d235082192954a33 798 SMART SM00028 580 613 0.02 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS20610 368addc38c6aacb9d235082192954a33 798 SMART SM00028 614 647 0.0029 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS20610 368addc38c6aacb9d235082192954a33 798 SMART SM00028 682 715 33.0 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS20610 368addc38c6aacb9d235082192954a33 798 SMART SM00028 648 681 3.0E-4 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS20610 368addc38c6aacb9d235082192954a33 798 SMART SM00028 716 749 5.8E-5 T 09-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 TK78_RS20610 368addc38c6aacb9d235082192954a33 798 Pfam PF13424 Tetratricopeptide repeat 585 645 1.1E-7 T 09-03-2017 TK78_RS20610 368addc38c6aacb9d235082192954a33 798 Pfam PF13414 TPR repeat 723 764 1.9E-11 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS20610 368addc38c6aacb9d235082192954a33 798 Gene3D G3DSA:1.25.40.10 542 633 2.0E-21 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS20610 368addc38c6aacb9d235082192954a33 798 Gene3D G3DSA:1.25.40.10 706 791 1.2E-20 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS20610 368addc38c6aacb9d235082192954a33 798 Gene3D G3DSA:1.25.40.10 634 705 3.8E-21 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS20610 368addc38c6aacb9d235082192954a33 798 SUPERFAMILY SSF48452 535 648 1.33E-21 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS20610 368addc38c6aacb9d235082192954a33 798 Pfam PF13432 Tetratricopeptide repeat 660 716 5.5E-6 T 09-03-2017 TK78_RS20610 368addc38c6aacb9d235082192954a33 798 Pfam PF13191 AAA ATPase domain 23 186 3.3E-8 T 09-03-2017 TK78_RS20610 368addc38c6aacb9d235082192954a33 798 SUPERFAMILY SSF48452 611 786 1.67E-42 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS33880 bcee57c15452dec92aab7b228fbc02cb 335 SUPERFAMILY SSF53807 57 327 1.53E-53 T 09-03-2017 TK78_RS33880 bcee57c15452dec92aab7b228fbc02cb 335 Gene3D G3DSA:3.40.50.1980 55 182 2.6E-29 T 09-03-2017 TK78_RS33880 bcee57c15452dec92aab7b228fbc02cb 335 Gene3D G3DSA:3.40.50.1980 185 332 5.4E-31 T 09-03-2017 TK78_RS33880 bcee57c15452dec92aab7b228fbc02cb 335 Pfam PF01497 Periplasmic binding protein 76 308 3.7E-26 T 09-03-2017 IPR002491 ABC transporter periplasmic binding domain GO:0005488 TK78_RS24925 5eebc9902f78ccde29ba7462f3fe7dff 316 Gene3D G3DSA:3.40.50.720 11 241 6.0E-48 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS24925 5eebc9902f78ccde29ba7462f3fe7dff 316 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 93 104 1.1E-9 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS24925 5eebc9902f78ccde29ba7462f3fe7dff 316 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 17 34 1.1E-9 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS24925 5eebc9902f78ccde29ba7462f3fe7dff 316 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 199 216 1.1E-9 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS24925 5eebc9902f78ccde29ba7462f3fe7dff 316 SUPERFAMILY SSF51735 13 265 6.41E-47 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS24925 5eebc9902f78ccde29ba7462f3fe7dff 316 Pfam PF00106 short chain dehydrogenase 16 217 1.1E-22 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS26415 344bcf29e6f67e8122944c20eff4b0c0 304 PIRSF PIRSF007580 1 294 1.2E-122 T 09-03-2017 IPR016516 Uncharacterised conserved protein UCP07580 TK78_RS26415 344bcf29e6f67e8122944c20eff4b0c0 304 Pfam PF10118 Predicted metal-dependent hydrolase 17 274 1.9E-79 T 09-03-2017 IPR016516 Uncharacterised conserved protein UCP07580 TK78_RS17140 fe72799f5b6025203397ecbb14ad4937 125 Pfam PF04020 Mycobacterial 4 TMS phage holin, superfamily IV 3 115 3.7E-29 T 09-03-2017 IPR007165 Mycobacterial 4 TMS phage holin, superfamily IV TK78_RS29105 257725c5a6980fefad0e08ebc108b199 430 SMART SM00922 177 271 1.8E-17 T 09-03-2017 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal TK78_RS29105 257725c5a6980fefad0e08ebc108b199 430 Gene3D G3DSA:3.20.20.120 145 384 2.0E-68 T 09-03-2017 IPR029065 Enolase C-terminal domain-like TK78_RS29105 257725c5a6980fefad0e08ebc108b199 430 Pfam PF13378 Enolase C-terminal domain-like 181 390 1.5E-47 T 09-03-2017 IPR029065 Enolase C-terminal domain-like TK78_RS29105 257725c5a6980fefad0e08ebc108b199 430 Gene3D G3DSA:3.30.390.10 3 144 7.2E-34 T 09-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS29105 257725c5a6980fefad0e08ebc108b199 430 Pfam PF02746 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain 36 142 9.6E-6 T 09-03-2017 IPR013341 Mandelate racemase/muconate lactonizing enzyme, N-terminal domain TK78_RS29105 257725c5a6980fefad0e08ebc108b199 430 SUPERFAMILY SSF51604 142 397 4.98E-67 T 09-03-2017 IPR029065 Enolase C-terminal domain-like TK78_RS29105 257725c5a6980fefad0e08ebc108b199 430 SUPERFAMILY SSF54826 5 142 4.21E-23 T 09-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TK78_RS28505 27923eeb3f2967dbc47fcf9e27f3ee75 142 Gene3D G3DSA:2.40.50.140 83 142 3.9E-24 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS28505 27923eeb3f2967dbc47fcf9e27f3ee75 142 Pfam PF01957 NfeD-like C-terminal, partner-binding 8 141 9.0E-18 T 09-03-2017 IPR002810 NfeD-like, C-terminal domain TK78_RS28505 27923eeb3f2967dbc47fcf9e27f3ee75 142 SUPERFAMILY SSF141322 74 141 2.09E-7 T 09-03-2017 TK78_RS19535 c6377b2b7481bb5907718b9afb10acec 485 SUPERFAMILY SSF53720 5 479 3.8E-143 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS19535 c6377b2b7481bb5907718b9afb10acec 485 Pfam PF00171 Aldehyde dehydrogenase family 25 473 2.5E-143 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS19535 c6377b2b7481bb5907718b9afb10acec 485 Gene3D G3DSA:3.40.605.10 10 267 2.8E-75 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS19535 c6377b2b7481bb5907718b9afb10acec 485 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 252 259 - T 09-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 TK78_RS19535 c6377b2b7481bb5907718b9afb10acec 485 Gene3D G3DSA:3.40.309.10 268 450 1.0E-58 T 09-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 TK78_RS21865 e01547d3e20a626a6e5ae3e3f71b9335 274 Gene3D G3DSA:3.40.50.150 16 252 8.2E-37 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS21865 e01547d3e20a626a6e5ae3e3f71b9335 274 SUPERFAMILY SSF53335 16 257 1.43E-37 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS21865 e01547d3e20a626a6e5ae3e3f71b9335 274 Pfam PF08241 Methyltransferase domain 53 143 1.8E-18 T 09-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 TK78_RS04865 7221eca0877c3df2d3607cc6bb3707fa 217 Gene3D G3DSA:1.10.357.10 57 202 1.3E-43 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS04865 7221eca0877c3df2d3607cc6bb3707fa 217 Gene3D G3DSA:1.10.10.60 8 56 2.1E-11 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS04865 7221eca0877c3df2d3607cc6bb3707fa 217 SUPERFAMILY SSF46689 12 79 5.64E-12 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS04865 7221eca0877c3df2d3607cc6bb3707fa 217 Pfam PF00440 Bacterial regulatory proteins, tetR family 20 64 8.8E-6 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS04865 7221eca0877c3df2d3607cc6bb3707fa 217 SUPERFAMILY SSF48498 86 201 1.95E-24 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS03740 62f682b593e95876181e4f097a3b76c1 433 Gene3D G3DSA:1.10.630.10 29 426 2.5E-79 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS03740 62f682b593e95876181e4f097a3b76c1 433 PRINTS PR00359 B-class P450 signature 162 178 9.0E-21 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS03740 62f682b593e95876181e4f097a3b76c1 433 PRINTS PR00359 B-class P450 signature 213 235 9.0E-21 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS03740 62f682b593e95876181e4f097a3b76c1 433 PRINTS PR00359 B-class P450 signature 361 370 9.0E-21 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS03740 62f682b593e95876181e4f097a3b76c1 433 PRINTS PR00359 B-class P450 signature 309 336 9.0E-21 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS03740 62f682b593e95876181e4f097a3b76c1 433 SUPERFAMILY SSF48264 34 425 1.57E-53 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS07445 a4c3de64dd386906f6b7783312954104 230 Gene3D G3DSA:3.40.50.2300 1 123 1.2E-37 T 09-03-2017 TK78_RS07445 a4c3de64dd386906f6b7783312954104 230 SUPERFAMILY SSF52172 1 187 8.54E-38 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS07445 a4c3de64dd386906f6b7783312954104 230 SMART SM00448 1 114 3.8E-40 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS07445 a4c3de64dd386906f6b7783312954104 230 SMART SM00862 153 225 1.2E-25 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS07445 a4c3de64dd386906f6b7783312954104 230 Pfam PF00072 Response regulator receiver domain 4 114 3.3E-26 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS07445 a4c3de64dd386906f6b7783312954104 230 Pfam PF00486 Transcriptional regulatory protein, C terminal 153 225 2.0E-25 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS07445 a4c3de64dd386906f6b7783312954104 230 Gene3D G3DSA:1.10.10.10 133 228 2.8E-31 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32500 65a95d8eb2460d0c64f75cc8da1a2648 249 SUPERFAMILY SSF52317 30 225 1.13E-40 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS32500 65a95d8eb2460d0c64f75cc8da1a2648 249 Gene3D G3DSA:3.40.50.880 3 214 6.4E-45 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS32500 65a95d8eb2460d0c64f75cc8da1a2648 249 Pfam PF07722 Peptidase C26 4 211 1.7E-64 T 09-03-2017 IPR011697 Peptidase C26 GO:0006541|GO:0016787 TK78_RS21955 cba2045a344b0b2a9e8750a83b214f21 429 Gene3D G3DSA:3.30.1330.100 1 46 3.6E-55 T 09-03-2017 TK78_RS21955 cba2045a344b0b2a9e8750a83b214f21 429 Gene3D G3DSA:3.30.1330.100 113 203 3.6E-55 T 09-03-2017 TK78_RS21955 cba2045a344b0b2a9e8750a83b214f21 429 Pfam PF01996 F420-0:Gamma-glutamyl ligase 7 63 6.8E-9 T 09-03-2017 IPR002847 Coenzyme F420:L-glutamate ligase-like domain KEGG: 00680+6.3.2.31+6.3.2.34|MetaCyc: PWY-5199 TK78_RS21955 cba2045a344b0b2a9e8750a83b214f21 429 Pfam PF01996 F420-0:Gamma-glutamyl ligase 76 198 1.4E-34 T 09-03-2017 IPR002847 Coenzyme F420:L-glutamate ligase-like domain KEGG: 00680+6.3.2.31+6.3.2.34|MetaCyc: PWY-5199 TK78_RS21955 cba2045a344b0b2a9e8750a83b214f21 429 Hamap MF_01259 Coenzyme F420:L-glutamate ligase [fbiB]. 4 429 51.824 T 09-03-2017 IPR023661 Coenzyme F420:L-glutamate ligase, bacteria GO:0043773|GO:0046872|GO:0051188 KEGG: 00680+6.3.2.31+6.3.2.34|MetaCyc: PWY-5199 TK78_RS21955 cba2045a344b0b2a9e8750a83b214f21 429 Pfam PF00881 Nitroreductase family 241 409 1.5E-26 T 09-03-2017 IPR029479 Nitroreductase Reactome: R-HSA-209968 TK78_RS21955 cba2045a344b0b2a9e8750a83b214f21 429 TIGRFAM TIGR03553 F420_FbiB_CTERM: F420 biosynthesis protein FbiB, C-terminal domain 236 429 5.2E-95 T 09-03-2017 IPR019943 Coenzyme F420 biosynthesis protein FbiB, C-terminal GO:0016881 KEGG: 00680+6.3.2.31+6.3.2.34|MetaCyc: PWY-5199 TK78_RS21955 cba2045a344b0b2a9e8750a83b214f21 429 Gene3D G3DSA:3.90.1660.10 47 112 1.0E-23 T 09-03-2017 TK78_RS21955 cba2045a344b0b2a9e8750a83b214f21 429 TIGRFAM TIGR01916 F420_cofE: coenzyme F420-0:L-glutamate ligase 1 227 8.3E-79 T 09-03-2017 IPR008225 Coenzyme F420:L-glutamate ligase GO:0043773|GO:0046872|GO:0051188 KEGG: 00680+6.3.2.31+6.3.2.34|MetaCyc: PWY-5199 TK78_RS21955 cba2045a344b0b2a9e8750a83b214f21 429 SUPERFAMILY SSF144010 3 232 8.37E-67 T 09-03-2017 TK78_RS21955 cba2045a344b0b2a9e8750a83b214f21 429 SUPERFAMILY SSF55469 234 426 4.71E-34 T 09-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TK78_RS21955 cba2045a344b0b2a9e8750a83b214f21 429 Gene3D G3DSA:3.40.109.10 231 426 2.3E-35 T 09-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TK78_RS27810 064c68400061858718cabb565ca70d43 338 TIGRFAM TIGR03718 R_switched_Alx: integral membrane protein, TerC family 4 312 3.7E-114 T 09-03-2017 IPR022369 Integral membrane protein TerC, riboswitch-linked GO:0016021 TK78_RS27810 064c68400061858718cabb565ca70d43 338 Pfam PF03741 Integral membrane protein TerC family 68 274 6.3E-54 T 09-03-2017 IPR005496 Integral membrane protein TerC GO:0016021 TK78_RS32115 d660e6424b124f0caa6b2b51e23604c8 449 Gene3D G3DSA:1.20.1250.20 223 428 1.9E-17 T 09-03-2017 TK78_RS32115 d660e6424b124f0caa6b2b51e23604c8 449 Gene3D G3DSA:1.20.1250.20 11 207 8.3E-21 T 09-03-2017 TK78_RS32115 d660e6424b124f0caa6b2b51e23604c8 449 Pfam PF07690 Major Facilitator Superfamily 26 378 7.6E-35 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS32115 d660e6424b124f0caa6b2b51e23604c8 449 SUPERFAMILY SSF103473 6 424 8.63E-49 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS02185 8708325c58c8e6528099bc982b082ca3 144 SUPERFAMILY SSF54427 9 141 1.92E-22 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS02185 8708325c58c8e6528099bc982b082ca3 144 Gene3D G3DSA:3.10.450.50 39 138 2.4E-18 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS02185 8708325c58c8e6528099bc982b082ca3 144 Pfam PF12680 SnoaL-like domain 38 128 4.0E-14 T 09-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain TK78_RS03635 bad329199c2f8f5a05ae9cc811d1621d 575 Pfam PF13515 Fusaric acid resistance protein-like 344 468 2.3E-18 T 09-03-2017 TK78_RS26605 b01b706735d2f18ca2d1c480591e4fff 173 Gene3D G3DSA:3.40.630.30 9 169 5.9E-28 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS26605 b01b706735d2f18ca2d1c480591e4fff 173 Pfam PF00583 Acetyltransferase (GNAT) family 69 144 9.1E-14 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS26605 b01b706735d2f18ca2d1c480591e4fff 173 SUPERFAMILY SSF55729 9 170 1.17E-28 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS06995 0699c85b0fcc937ee0c808f12a49a40b 429 SUPERFAMILY SSF53756 83 423 1.79E-82 T 09-03-2017 TK78_RS06995 0699c85b0fcc937ee0c808f12a49a40b 429 SUPERFAMILY SSF53756 1 56 1.79E-82 T 09-03-2017 TK78_RS06995 0699c85b0fcc937ee0c808f12a49a40b 429 TIGRFAM TIGR04516 glycosyl_450act: glycosyltransferase, activator-dependent family 1 424 2.0E-151 T 09-03-2017 IPR030953 Glycosyltransferase, activator-dependent family GO:0016757 TK78_RS06995 0699c85b0fcc937ee0c808f12a49a40b 429 Gene3D G3DSA:3.40.50.2000 1 255 3.2E-47 T 09-03-2017 TK78_RS06995 0699c85b0fcc937ee0c808f12a49a40b 429 Pfam PF06722 Protein of unknown function (DUF1205) 213 306 1.8E-18 T 09-03-2017 IPR010610 Domain of unknown function DUF1205 TK78_RS06995 0699c85b0fcc937ee0c808f12a49a40b 429 Gene3D G3DSA:3.40.50.2000 256 403 8.2E-24 T 09-03-2017 TK78_RS30655 c8cf2bfe40e2cfcbd0464e159f8bcafc 1014 Gene3D G3DSA:3.30.565.10 521 631 6.8E-13 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS30655 c8cf2bfe40e2cfcbd0464e159f8bcafc 1014 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 521 625 9.8E-7 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS30655 c8cf2bfe40e2cfcbd0464e159f8bcafc 1014 Pfam PF00672 HAMP domain 317 401 1.5E-9 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS30655 c8cf2bfe40e2cfcbd0464e159f8bcafc 1014 Pfam PF08376 Nitrate and nitrite sensing 58 288 3.2E-36 T 09-03-2017 IPR013587 Nitrate/nitrite sensing protein TK78_RS30655 c8cf2bfe40e2cfcbd0464e159f8bcafc 1014 SMART SM00387 517 627 6.3E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS30655 c8cf2bfe40e2cfcbd0464e159f8bcafc 1014 SUPERFAMILY SSF55874 506 625 1.22E-16 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS19910 6662c47d58f0a5bd10d9600592c448d2 302 Gene3D G3DSA:3.40.50.300 12 243 1.4E-64 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS19910 6662c47d58f0a5bd10d9600592c448d2 302 Pfam PF00005 ABC transporter 35 178 1.1E-27 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS19910 6662c47d58f0a5bd10d9600592c448d2 302 ProSitePatterns PS00211 ABC transporters family signature. 151 165 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS19910 6662c47d58f0a5bd10d9600592c448d2 302 SMART SM00382 43 234 4.9E-11 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS19910 6662c47d58f0a5bd10d9600592c448d2 302 SUPERFAMILY SSF52540 19 240 7.03E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24530 4c91eb5c3087958f9983e44c5658593a 85 Hamap MF_00539 50S ribosomal protein L27 [rpmA]. 1 83 26.922 T 09-03-2017 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS24530 4c91eb5c3087958f9983e44c5658593a 85 SUPERFAMILY SSF110324 2 81 8.72E-31 T 09-03-2017 TK78_RS24530 4c91eb5c3087958f9983e44c5658593a 85 PRINTS PR00063 Ribosomal protein L27 signature 29 53 3.8E-35 T 09-03-2017 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS24530 4c91eb5c3087958f9983e44c5658593a 85 PRINTS PR00063 Ribosomal protein L27 signature 4 28 3.8E-35 T 09-03-2017 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS24530 4c91eb5c3087958f9983e44c5658593a 85 PRINTS PR00063 Ribosomal protein L27 signature 54 78 3.8E-35 T 09-03-2017 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS24530 4c91eb5c3087958f9983e44c5658593a 85 ProSitePatterns PS00831 Ribosomal protein L27 signature. 34 48 - T 09-03-2017 IPR018261 Ribosomal protein L27, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS24530 4c91eb5c3087958f9983e44c5658593a 85 ProDom PD003114 RIBOSOMAL L27 50S RIBONUCLEOPROTEIN CHLOROPLAST MITOCHONDRIAL PEPTIDE 60S TRANSIT PRECURSOR 28 72 6.0E-18 T 09-03-2017 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS24530 4c91eb5c3087958f9983e44c5658593a 85 Gene3D G3DSA:2.40.50.100 20 81 1.1E-28 T 09-03-2017 TK78_RS24530 4c91eb5c3087958f9983e44c5658593a 85 TIGRFAM TIGR00062 L27: ribosomal protein bL27 1 81 8.2E-35 T 09-03-2017 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS24530 4c91eb5c3087958f9983e44c5658593a 85 Pfam PF01016 Ribosomal L27 protein 2 80 8.8E-36 T 09-03-2017 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS07815 e41f5f6ec33f15bd27656fd608cf85a8 97 SUPERFAMILY SSF103007 1 94 3.92E-31 T 09-03-2017 IPR007546 Protein of unknown function DUF503 TK78_RS07815 e41f5f6ec33f15bd27656fd608cf85a8 97 Pfam PF04456 Protein of unknown function (DUF503) 3 89 9.3E-33 T 09-03-2017 IPR007546 Protein of unknown function DUF503 TK78_RS07815 e41f5f6ec33f15bd27656fd608cf85a8 97 Gene3D G3DSA:3.30.70.1120 1 96 2.4E-37 T 09-03-2017 IPR007546 Protein of unknown function DUF503 TK78_RS16460 cc5dc8d557dbbb527f209c622128d194 163 Gene3D G3DSA:3.40.30.10 4 140 1.1E-38 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS16460 cc5dc8d557dbbb527f209c622128d194 163 SUPERFAMILY SSF52833 4 145 3.52E-36 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS16460 cc5dc8d557dbbb527f209c622128d194 163 Pfam PF00578 AhpC/TSA family 8 137 8.0E-31 T 09-03-2017 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15|Reactome: R-HSA-3299685 TK78_RS16460 cc5dc8d557dbbb527f209c622128d194 163 PIRSF PIRSF000239 2 146 1.1E-19 T 09-03-2017 IPR024706 Peroxiredoxin, AhpC-type KEGG: 00480+1.11.1.15|Reactome: R-HSA-3299685 TK78_RS27770 e3fa19bce0648a2a2f3140c1cd8cd65f 405 Gene3D G3DSA:1.20.1250.20 218 388 4.1E-18 T 09-03-2017 TK78_RS27770 e3fa19bce0648a2a2f3140c1cd8cd65f 405 Gene3D G3DSA:1.20.1250.20 8 184 2.8E-12 T 09-03-2017 TK78_RS27770 e3fa19bce0648a2a2f3140c1cd8cd65f 405 Pfam PF07690 Major Facilitator Superfamily 4 240 1.1E-13 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS27770 e3fa19bce0648a2a2f3140c1cd8cd65f 405 SUPERFAMILY SSF103473 2 393 1.2E-39 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS09290 f386bf84d9e1e514f5633c1ca6cc44c6 610 Gene3D G3DSA:3.40.50.300 370 594 1.7E-77 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09290 f386bf84d9e1e514f5633c1ca6cc44c6 610 SMART SM00382 395 581 9.8E-19 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS09290 f386bf84d9e1e514f5633c1ca6cc44c6 610 ProSitePatterns PS00211 ABC transporters family signature. 507 521 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS09290 f386bf84d9e1e514f5633c1ca6cc44c6 610 Pfam PF00664 ABC transporter transmembrane region 46 313 1.6E-30 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS09290 f386bf84d9e1e514f5633c1ca6cc44c6 610 Gene3D G3DSA:1.20.1560.10 34 350 1.6E-72 T 09-03-2017 TK78_RS09290 f386bf84d9e1e514f5633c1ca6cc44c6 610 SUPERFAMILY SSF90123 34 355 5.49E-61 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS09290 f386bf84d9e1e514f5633c1ca6cc44c6 610 SUPERFAMILY SSF52540 367 604 5.97E-82 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09290 f386bf84d9e1e514f5633c1ca6cc44c6 610 Pfam PF00005 ABC transporter 389 535 7.9E-32 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS08070 99dd74f271b51ac148a941fb4ed39978 185 TIGRFAM TIGR00496 frr: ribosome recycling factor 10 185 8.9E-61 T 09-03-2017 IPR002661 Ribosome recycling factor GO:0006412 Reactome: R-HSA-5419276 TK78_RS08070 99dd74f271b51ac148a941fb4ed39978 185 Pfam PF01765 Ribosome recycling factor 21 183 7.0E-57 T 09-03-2017 IPR023584 Ribosome recycling factor domain Reactome: R-HSA-5419276 TK78_RS08070 99dd74f271b51ac148a941fb4ed39978 185 Hamap MF_00040 Ribosome-recycling factor [frr]. 3 185 26.553 T 09-03-2017 IPR002661 Ribosome recycling factor GO:0006412 Reactome: R-HSA-5419276 TK78_RS08070 99dd74f271b51ac148a941fb4ed39978 185 Gene3D G3DSA:1.10.132.20 66 185 6.3E-39 T 09-03-2017 IPR023584 Ribosome recycling factor domain Reactome: R-HSA-5419276 TK78_RS08070 99dd74f271b51ac148a941fb4ed39978 185 SUPERFAMILY SSF55194 3 184 1.96E-65 T 09-03-2017 IPR023584 Ribosome recycling factor domain Reactome: R-HSA-5419276 TK78_RS24830 19c0afaa47ab01611537183b003b30ee 471 Gene3D G3DSA:1.20.1250.20 282 465 3.5E-18 T 09-03-2017 TK78_RS24830 19c0afaa47ab01611537183b003b30ee 471 Gene3D G3DSA:1.20.1250.20 33 212 1.1E-30 T 09-03-2017 TK78_RS24830 19c0afaa47ab01611537183b003b30ee 471 Pfam PF07690 Major Facilitator Superfamily 37 328 2.3E-38 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS24830 19c0afaa47ab01611537183b003b30ee 471 SUPERFAMILY SSF103473 267 467 9.16E-64 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS24830 19c0afaa47ab01611537183b003b30ee 471 SUPERFAMILY SSF103473 20 219 9.16E-64 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS24830 19c0afaa47ab01611537183b003b30ee 471 PRINTS PR01036 Tetracycline resistance protein TetB signature 157 181 2.2E-6 T 09-03-2017 TK78_RS24830 19c0afaa47ab01611537183b003b30ee 471 PRINTS PR01036 Tetracycline resistance protein TetB signature 35 59 2.2E-6 T 09-03-2017 TK78_RS24830 19c0afaa47ab01611537183b003b30ee 471 PRINTS PR01036 Tetracycline resistance protein TetB signature 95 117 2.2E-6 T 09-03-2017 TK78_RS08025 ea81584bb475480dfb7d45b6dd98a87e 386 SUPERFAMILY SSF53756 7 385 1.77E-69 T 09-03-2017 TK78_RS08025 ea81584bb475480dfb7d45b6dd98a87e 386 Pfam PF00534 Glycosyl transferases group 1 199 366 5.2E-38 T 09-03-2017 IPR001296 Glycosyl transferase, family 1 TK78_RS08025 ea81584bb475480dfb7d45b6dd98a87e 386 Gene3D G3DSA:3.40.50.2000 192 364 2.4E-35 T 09-03-2017 TK78_RS19010 5f018833fea86bea6470eb1d7a88d6ef 247 SUPERFAMILY SSF53335 11 245 9.95E-29 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS19010 5f018833fea86bea6470eb1d7a88d6ef 247 Gene3D G3DSA:3.40.50.150 179 226 6.0E-26 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS19010 5f018833fea86bea6470eb1d7a88d6ef 247 Gene3D G3DSA:3.40.50.150 7 146 6.0E-26 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS19010 5f018833fea86bea6470eb1d7a88d6ef 247 Pfam PF13649 Methyltransferase domain 45 137 5.0E-10 T 09-03-2017 TK78_RS29705 39f1b632fe5b1d2e2e63596c7cf37fa8 299 SUPERFAMILY SSF103481 33 129 2.62E-9 T 09-03-2017 TK78_RS29705 39f1b632fe5b1d2e2e63596c7cf37fa8 299 SUPERFAMILY SSF103481 188 280 2.09E-8 T 09-03-2017 TK78_RS29705 39f1b632fe5b1d2e2e63596c7cf37fa8 299 Pfam PF00892 EamA-like transporter family 3 127 3.1E-12 T 09-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 TK78_RS29705 39f1b632fe5b1d2e2e63596c7cf37fa8 299 Pfam PF00892 EamA-like transporter family 140 271 2.2E-10 T 09-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 TK78_RS25790 8de7c73fb835d3d9a89092ecbd413737 576 ProSitePatterns PS00211 ABC transporters family signature. 142 156 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS25790 8de7c73fb835d3d9a89092ecbd413737 576 Pfam PF00005 ABC transporter 342 483 3.7E-24 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS25790 8de7c73fb835d3d9a89092ecbd413737 576 Pfam PF00005 ABC transporter 19 170 3.2E-26 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS25790 8de7c73fb835d3d9a89092ecbd413737 576 Gene3D G3DSA:3.40.50.300 1 231 1.1E-60 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS25790 8de7c73fb835d3d9a89092ecbd413737 576 SMART SM00382 28 219 1.2E-12 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS25790 8de7c73fb835d3d9a89092ecbd413737 576 SMART SM00382 351 532 5.1E-13 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS25790 8de7c73fb835d3d9a89092ecbd413737 576 SUPERFAMILY SSF52540 2 230 1.91E-56 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS25790 8de7c73fb835d3d9a89092ecbd413737 576 Gene3D G3DSA:3.40.50.300 325 543 8.3E-54 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS25790 8de7c73fb835d3d9a89092ecbd413737 576 SUPERFAMILY SSF52540 319 542 3.06E-52 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01670 42c85ef1814086bd438d5ed4e5882596 416 Pfam PF02156 Glycosyl hydrolase family 26 185 270 1.3E-5 T 09-03-2017 IPR022790 Glycosyl hydrolase family 26 domain GO:0004553 TK78_RS01670 42c85ef1814086bd438d5ed4e5882596 416 SUPERFAMILY SSF51445 52 309 1.51E-35 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS01670 42c85ef1814086bd438d5ed4e5882596 416 Gene3D G3DSA:3.20.20.80 47 333 5.5E-46 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS05850 93a4a1cf9e98c0f50813ccc3ffd56831 283 Pfam PF01522 Polysaccharide deacetylase 68 209 1.2E-23 T 09-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 TK78_RS05850 93a4a1cf9e98c0f50813ccc3ffd56831 283 SUPERFAMILY SSF88713 68 280 1.88E-42 T 09-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 TK78_RS05850 93a4a1cf9e98c0f50813ccc3ffd56831 283 Gene3D G3DSA:3.20.20.370 68 280 2.5E-43 T 09-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 TK78_RS24655 7710c7f1c0abd0954458f5f677c08443 227 SUPERFAMILY SSF142984 82 117 6.54E-5 T 09-03-2017 TK78_RS24655 7710c7f1c0abd0954458f5f677c08443 227 Pfam PF10531 SLBB domain 81 132 1.4E-9 T 09-03-2017 IPR019554 Soluble ligand binding domain Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS24655 7710c7f1c0abd0954458f5f677c08443 227 Gene3D G3DSA:1.10.150.280 167 224 4.3E-16 T 09-03-2017 TK78_RS24655 7710c7f1c0abd0954458f5f677c08443 227 SUPERFAMILY SSF47781 161 223 3.89E-23 T 09-03-2017 IPR010994 RuvA domain 2-like TK78_RS24655 7710c7f1c0abd0954458f5f677c08443 227 Pfam PF12836 Helix-hairpin-helix motif 164 226 2.8E-19 T 09-03-2017 TK78_RS24655 7710c7f1c0abd0954458f5f677c08443 227 Gene3D G3DSA:3.10.560.10 82 134 6.9E-6 T 09-03-2017 TK78_RS00300 69e682e029f39f1c1d052345a76e157f 504 PIRSF PIRSF006429 4 494 6.8E-139 T 09-03-2017 IPR024188 Glutamate synthase large subunit-like protein TK78_RS00300 69e682e029f39f1c1d052345a76e157f 504 Pfam PF01645 Conserved region in glutamate synthase 138 453 1.8E-75 T 09-03-2017 IPR002932 Glutamate synthase domain GO:0006537|GO:0015930|GO:0016638|GO:0055114 TK78_RS00300 69e682e029f39f1c1d052345a76e157f 504 SUPERFAMILY SSF51395 11 477 1.83E-112 T 09-03-2017 TK78_RS00300 69e682e029f39f1c1d052345a76e157f 504 Gene3D G3DSA:3.20.20.70 22 474 3.4E-107 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS23495 6e79011423bdfd46798c8080471e5e9a 562 Gene3D G3DSA:3.90.550.10 100 321 1.2E-22 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS23495 6e79011423bdfd46798c8080471e5e9a 562 Pfam PF13641 Glycosyltransferase like family 2 96 319 2.4E-27 T 09-03-2017 TK78_RS23495 6e79011423bdfd46798c8080471e5e9a 562 SUPERFAMILY SSF53448 98 356 2.3E-39 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS14540 1966bd1b764628c6002568bb969275f9 325 SUPERFAMILY SSF53474 6 321 8.88E-59 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS14540 1966bd1b764628c6002568bb969275f9 325 PIRSF PIRSF006431 4 324 3.2E-117 T 09-03-2017 IPR005944 Proline iminopeptidase GO:0004177|GO:0005737|GO:0006508 KEGG: 00330+3.4.11.5 TK78_RS14540 1966bd1b764628c6002568bb969275f9 325 Gene3D G3DSA:3.40.50.1820 12 321 2.8E-60 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS14540 1966bd1b764628c6002568bb969275f9 325 TIGRFAM TIGR01249 pro_imino_pep_1: prolyl aminopeptidase 14 310 4.5E-96 T 09-03-2017 IPR005944 Proline iminopeptidase GO:0004177|GO:0005737|GO:0006508 KEGG: 00330+3.4.11.5 TK78_RS14540 1966bd1b764628c6002568bb969275f9 325 PRINTS PR00111 Alpha/beta hydrolase fold signature 130 143 1.1E-5 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS14540 1966bd1b764628c6002568bb969275f9 325 PRINTS PR00111 Alpha/beta hydrolase fold signature 65 80 1.1E-5 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS14540 1966bd1b764628c6002568bb969275f9 325 PRINTS PR00111 Alpha/beta hydrolase fold signature 116 129 1.1E-5 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS14540 1966bd1b764628c6002568bb969275f9 325 Pfam PF00561 alpha/beta hydrolase fold 43 305 1.5E-27 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS14540 1966bd1b764628c6002568bb969275f9 325 PRINTS PR00793 Prolyl aminopeptidase (S33) family signature 68 79 7.9E-13 T 09-03-2017 IPR002410 Peptidase S33 GO:0006508|GO:0008233 KEGG: 00330+3.4.11.5 TK78_RS14540 1966bd1b764628c6002568bb969275f9 325 PRINTS PR00793 Prolyl aminopeptidase (S33) family signature 42 50 7.9E-13 T 09-03-2017 IPR002410 Peptidase S33 GO:0006508|GO:0008233 KEGG: 00330+3.4.11.5 TK78_RS14540 1966bd1b764628c6002568bb969275f9 325 PRINTS PR00793 Prolyl aminopeptidase (S33) family signature 116 130 7.9E-13 T 09-03-2017 IPR002410 Peptidase S33 GO:0006508|GO:0008233 KEGG: 00330+3.4.11.5 TK78_RS05160 61eeb5837f0ce26999942befd8fb0fa2 1277 SUPERFAMILY SSF52540 349 589 2.55E-79 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS05160 61eeb5837f0ce26999942befd8fb0fa2 1277 SMART SM00382 1047 1233 1.1E-18 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS05160 61eeb5837f0ce26999942befd8fb0fa2 1277 SMART SM00382 381 575 1.8E-14 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS05160 61eeb5837f0ce26999942befd8fb0fa2 1277 Gene3D G3DSA:1.20.1560.10 694 1005 6.3E-72 T 09-03-2017 TK78_RS05160 61eeb5837f0ce26999942befd8fb0fa2 1277 Gene3D G3DSA:1.20.1560.10 29 344 7.6E-68 T 09-03-2017 TK78_RS05160 61eeb5837f0ce26999942befd8fb0fa2 1277 SUPERFAMILY SSF52540 1011 1256 1.16E-82 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS05160 61eeb5837f0ce26999942befd8fb0fa2 1277 SUPERFAMILY SSF90123 29 344 2.62E-71 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS05160 61eeb5837f0ce26999942befd8fb0fa2 1277 Pfam PF00005 ABC transporter 1038 1187 3.4E-32 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS05160 61eeb5837f0ce26999942befd8fb0fa2 1277 Pfam PF00005 ABC transporter 372 521 4.1E-29 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS05160 61eeb5837f0ce26999942befd8fb0fa2 1277 Gene3D G3DSA:3.40.50.300 355 582 1.9E-73 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS05160 61eeb5837f0ce26999942befd8fb0fa2 1277 Gene3D G3DSA:3.40.50.300 1020 1251 4.1E-78 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS05160 61eeb5837f0ce26999942befd8fb0fa2 1277 Pfam PF00664 ABC transporter transmembrane region 704 973 5.1E-41 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS05160 61eeb5837f0ce26999942befd8fb0fa2 1277 Pfam PF00664 ABC transporter transmembrane region 42 310 1.1E-31 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS05160 61eeb5837f0ce26999942befd8fb0fa2 1277 ProSitePatterns PS00211 ABC transporters family signature. 493 507 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS05160 61eeb5837f0ce26999942befd8fb0fa2 1277 SUPERFAMILY SSF90123 692 1001 2.88E-68 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS31505 73e2558be1a139e58e232a6e553337af 477 TIGRFAM TIGR00928 purB: adenylosuccinate lyase 11 454 3.8E-126 T 09-03-2017 IPR004769 Adenylosuccinate lyase GO:0004018|GO:0009152 KEGG: 00230+4.3.2.2|KEGG: 00250+4.3.2.2|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7219|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TK78_RS31505 73e2558be1a139e58e232a6e553337af 477 Gene3D G3DSA:1.10.275.10 13 101 5.7E-23 T 09-03-2017 IPR024083 Fumarase/histidase, N-terminal TK78_RS31505 73e2558be1a139e58e232a6e553337af 477 ProSitePatterns PS00163 Fumarate lyases signature. 280 289 - T 09-03-2017 IPR020557 Fumarate lyase, conserved site GO:0003824 TK78_RS31505 73e2558be1a139e58e232a6e553337af 477 PRINTS PR00149 Fumarate lyase superfamily signature 143 161 4.0E-9 T 09-03-2017 IPR000362 Fumarate lyase family TK78_RS31505 73e2558be1a139e58e232a6e553337af 477 PRINTS PR00149 Fumarate lyase superfamily signature 98 116 4.0E-9 T 09-03-2017 IPR000362 Fumarate lyase family TK78_RS31505 73e2558be1a139e58e232a6e553337af 477 PRINTS PR00149 Fumarate lyase superfamily signature 280 296 4.0E-9 T 09-03-2017 IPR000362 Fumarate lyase family TK78_RS31505 73e2558be1a139e58e232a6e553337af 477 Pfam PF00206 Lyase 53 300 5.3E-19 T 09-03-2017 IPR022761 Fumarate lyase, N-terminal TK78_RS31505 73e2558be1a139e58e232a6e553337af 477 Pfam PF10397 Adenylosuccinate lyase C-terminus 370 452 4.2E-11 T 09-03-2017 IPR019468 Adenylosuccinate lyase C-terminal KEGG: 00230+4.3.2.2|KEGG: 00250+4.3.2.2|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7219|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TK78_RS31505 73e2558be1a139e58e232a6e553337af 477 SUPERFAMILY SSF48557 10 456 1.3E-79 T 09-03-2017 IPR008948 L-Aspartase-like GO:0003824 TK78_RS31505 73e2558be1a139e58e232a6e553337af 477 SMART SM00998 369 455 1.2E-18 T 09-03-2017 IPR019468 Adenylosuccinate lyase C-terminal KEGG: 00230+4.3.2.2|KEGG: 00250+4.3.2.2|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7219|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TK78_RS31505 73e2558be1a139e58e232a6e553337af 477 Gene3D G3DSA:1.20.200.10 102 452 7.3E-81 T 09-03-2017 TK78_RS34430 e28cbec049df583f9c985c0efba4e032 542 SUPERFAMILY SSF55103 286 539 1.96E-30 T 09-03-2017 IPR016164 FAD-linked oxidase-like, C-terminal GO:0003824|GO:0050660 TK78_RS34430 e28cbec049df583f9c985c0efba4e032 542 Pfam PF02913 FAD linked oxidases, C-terminal domain 283 535 7.4E-38 T 09-03-2017 IPR004113 FAD-linked oxidase, C-terminal GO:0003824|GO:0050660 TK78_RS34430 e28cbec049df583f9c985c0efba4e032 542 Gene3D G3DSA:1.10.45.10 519 535 4.2E-5 T 09-03-2017 IPR016171 Vanillyl-alcohol oxidase, C-terminal subdomain 2 TK78_RS34430 e28cbec049df583f9c985c0efba4e032 542 Gene3D G3DSA:3.30.43.10 80 162 5.1E-9 T 09-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 TK78_RS34430 e28cbec049df583f9c985c0efba4e032 542 Gene3D G3DSA:3.30.465.10 164 283 7.9E-20 T 09-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 TK78_RS34430 e28cbec049df583f9c985c0efba4e032 542 Pfam PF01565 FAD binding domain 105 242 2.7E-30 T 09-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 TK78_RS34430 e28cbec049df583f9c985c0efba4e032 542 SUPERFAMILY SSF56176 77 283 2.66E-39 T 09-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 TK78_RS17590 6619b7640368f5b418f5ff83b36e6b11 238 SUPERFAMILY SSF47240 4 232 5.41E-62 T 09-03-2017 IPR009078 Ferritin-like superfamily TK78_RS17590 6619b7640368f5b418f5ff83b36e6b11 238 Pfam PF05138 Phenylacetic acid catabolic protein 4 238 1.8E-75 T 09-03-2017 IPR007814 1,2-phenylacetyl-CoA epoxidase, subunit A/C GO:0010124 TK78_RS17590 6619b7640368f5b418f5ff83b36e6b11 238 PIRSF PIRSF037834 1 238 1.6E-90 T 09-03-2017 IPR011882 1,2-phenylacetyl-CoA epoxidase, subunit C GO:0010124 TK78_RS17590 6619b7640368f5b418f5ff83b36e6b11 238 TIGRFAM TIGR02158 PA_CoA_Oxy3: phenylacetate-CoA oxygenase, PaaI subunit 7 238 1.7E-76 T 09-03-2017 IPR011882 1,2-phenylacetyl-CoA epoxidase, subunit C GO:0010124 TK78_RS17590 6619b7640368f5b418f5ff83b36e6b11 238 Gene3D G3DSA:1.20.1260.10 4 238 5.0E-82 T 09-03-2017 IPR012347 Ferritin-related TK78_RS19805 01e11c7c2480d98becb600845b67b700 842 SUPERFAMILY SSF81923 3 144 2.94E-33 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS19805 01e11c7c2480d98becb600845b67b700 842 Gene3D G3DSA:3.40.50.300 168 348 5.1E-47 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS19805 01e11c7c2480d98becb600845b67b700 842 Gene3D G3DSA:1.10.8.60 732 817 4.0E-32 T 09-03-2017 TK78_RS19805 01e11c7c2480d98becb600845b67b700 842 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 210 330 1.1E-12 T 09-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 TK78_RS19805 01e11c7c2480d98becb600845b67b700 842 SMART SM01086 720 811 5.4E-38 T 09-03-2017 IPR019489 Clp ATPase, C-terminal TK78_RS19805 01e11c7c2480d98becb600845b67b700 842 Gene3D G3DSA:3.40.50.300 703 731 2.9E-59 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS19805 01e11c7c2480d98becb600845b67b700 842 Gene3D G3DSA:3.40.50.300 495 668 2.9E-59 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS19805 01e11c7c2480d98becb600845b67b700 842 Gene3D G3DSA:1.10.1780.10 1 142 3.1E-54 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS19805 01e11c7c2480d98becb600845b67b700 842 SUPERFAMILY SSF52540 168 446 1.4E-73 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS19805 01e11c7c2480d98becb600845b67b700 842 Pfam PF07724 AAA domain (Cdc48 subfamily) 542 713 2.0E-54 T 09-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 TK78_RS19805 01e11c7c2480d98becb600845b67b700 842 ProSitePatterns PS00870 Chaperonins clpA/B signature 1. 300 312 - T 09-03-2017 IPR018368 ClpA/B, conserved site 1 GO:0005524 TK78_RS19805 01e11c7c2480d98becb600845b67b700 842 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 546 564 6.2E-40 T 09-03-2017 IPR001270 ClpA/B family GO:0005524 TK78_RS19805 01e11c7c2480d98becb600845b67b700 842 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 620 638 6.2E-40 T 09-03-2017 IPR001270 ClpA/B family GO:0005524 TK78_RS19805 01e11c7c2480d98becb600845b67b700 842 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 653 667 6.2E-40 T 09-03-2017 IPR001270 ClpA/B family GO:0005524 TK78_RS19805 01e11c7c2480d98becb600845b67b700 842 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 591 609 6.2E-40 T 09-03-2017 IPR001270 ClpA/B family GO:0005524 TK78_RS19805 01e11c7c2480d98becb600845b67b700 842 SMART SM00382 542 690 2.4E-11 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS19805 01e11c7c2480d98becb600845b67b700 842 SMART SM00382 205 349 5.9E-10 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS19805 01e11c7c2480d98becb600845b67b700 842 Pfam PF10431 C-terminal, D2-small domain, of ClpB protein 720 799 1.3E-27 T 09-03-2017 IPR019489 Clp ATPase, C-terminal TK78_RS19805 01e11c7c2480d98becb600845b67b700 842 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 16 68 3.2E-19 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS19805 01e11c7c2480d98becb600845b67b700 842 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 93 142 4.5E-17 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS19805 01e11c7c2480d98becb600845b67b700 842 Pfam PF02151 UvrB/uvrC motif 422 454 5.8E-7 T 09-03-2017 IPR001943 UVR domain GO:0005515 TK78_RS19805 01e11c7c2480d98becb600845b67b700 842 Gene3D G3DSA:1.10.8.60 351 433 1.6E-33 T 09-03-2017 TK78_RS19805 01e11c7c2480d98becb600845b67b700 842 SUPERFAMILY SSF52540 491 800 6.05E-79 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24790 49009fc4eef205f3974d46da4da6db36 304 SUPERFAMILY SSF56281 5 297 3.54E-60 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS24790 49009fc4eef205f3974d46da4da6db36 304 Pfam PF12706 Beta-lactamase superfamily domain 181 264 3.4E-11 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS24790 49009fc4eef205f3974d46da4da6db36 304 Pfam PF00753 Metallo-beta-lactamase superfamily 20 105 2.8E-13 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS24790 49009fc4eef205f3974d46da4da6db36 304 Hamap MF_01818 Ribonuclease BN [rbn]. 4 298 30.482 T 09-03-2017 IPR013471 Ribonuclease Z/BN GO:0016891|GO:0042779 TK78_RS24790 49009fc4eef205f3974d46da4da6db36 304 Gene3D G3DSA:3.60.15.10 5 301 3.3E-71 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS07340 af09edd57bed22882bc90c436fcadeca 965 TIGRFAM TIGR02504 NrdJ_Z: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent 98 707 3.5E-187 T 09-03-2017 IPR013344 Ribonucleotide reductase, adenosylcobalamin-dependent GO:0000166|GO:0004748|GO:0031419|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227 TK78_RS07340 af09edd57bed22882bc90c436fcadeca 965 Pfam PF02867 Ribonucleotide reductase, barrel domain 158 697 1.1E-147 T 09-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TK78_RS07340 af09edd57bed22882bc90c436fcadeca 965 PRINTS PR01183 Ribonucleotide reductase large chain signature 398 421 6.0E-15 T 09-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TK78_RS07340 af09edd57bed22882bc90c436fcadeca 965 PRINTS PR01183 Ribonucleotide reductase large chain signature 543 570 6.0E-15 T 09-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TK78_RS07340 af09edd57bed22882bc90c436fcadeca 965 PRINTS PR01183 Ribonucleotide reductase large chain signature 360 371 6.0E-15 T 09-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TK78_RS07340 af09edd57bed22882bc90c436fcadeca 965 PRINTS PR01183 Ribonucleotide reductase large chain signature 436 458 6.0E-15 T 09-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TK78_RS07340 af09edd57bed22882bc90c436fcadeca 965 PRINTS PR01183 Ribonucleotide reductase large chain signature 464 487 6.0E-15 T 09-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TK78_RS07340 af09edd57bed22882bc90c436fcadeca 965 PRINTS PR01183 Ribonucleotide reductase large chain signature 233 252 6.0E-15 T 09-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TK78_RS07340 af09edd57bed22882bc90c436fcadeca 965 Pfam PF08471 Class II vitamin B12-dependent ribonucleotide reductase 54 137 8.4E-19 T 09-03-2017 IPR013678 Ribonucleotide reductase class II vitamin B12-dependent, N-terminal domain GO:0004748|GO:0050897|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227 TK78_RS07340 af09edd57bed22882bc90c436fcadeca 965 Gene3D G3DSA:3.20.70.20 543 589 1.7E-99 T 09-03-2017 TK78_RS07340 af09edd57bed22882bc90c436fcadeca 965 Gene3D G3DSA:3.20.70.20 656 701 1.7E-99 T 09-03-2017 TK78_RS07340 af09edd57bed22882bc90c436fcadeca 965 Gene3D G3DSA:3.20.70.20 68 484 1.7E-99 T 09-03-2017 TK78_RS07340 af09edd57bed22882bc90c436fcadeca 965 SUPERFAMILY SSF51998 630 709 6.1E-131 T 09-03-2017 TK78_RS07340 af09edd57bed22882bc90c436fcadeca 965 SUPERFAMILY SSF51998 158 595 6.1E-131 T 09-03-2017 TK78_RS05715 7313113eb422c31db8217ce8215efd78 308 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 5 63 3.0E-19 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS05715 7313113eb422c31db8217ce8215efd78 308 Pfam PF03466 LysR substrate binding domain 88 296 7.1E-37 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS05715 7313113eb422c31db8217ce8215efd78 308 Gene3D G3DSA:3.40.190.10 181 270 1.5E-26 T 09-03-2017 TK78_RS05715 7313113eb422c31db8217ce8215efd78 308 SUPERFAMILY SSF46785 1 112 2.56E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05715 7313113eb422c31db8217ce8215efd78 308 SUPERFAMILY SSF53850 89 296 1.21E-34 T 09-03-2017 TK78_RS05715 7313113eb422c31db8217ce8215efd78 308 Gene3D G3DSA:1.10.10.10 1 86 1.2E-24 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05715 7313113eb422c31db8217ce8215efd78 308 Gene3D G3DSA:3.40.190.10 90 180 5.4E-15 T 09-03-2017 TK78_RS01460 04ea0ae52e03fc48f2e4b4c213c9af08 292 SUPERFAMILY SSF51695 206 278 3.92E-15 T 09-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 TK78_RS01460 04ea0ae52e03fc48f2e4b4c213c9af08 292 SUPERFAMILY SSF51695 44 167 3.92E-15 T 09-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 TK78_RS01460 04ea0ae52e03fc48f2e4b4c213c9af08 292 Pfam PF13653 Glycerophosphoryl diester phosphodiesterase family 241 276 1.8E-9 T 09-03-2017 TK78_RS01460 04ea0ae52e03fc48f2e4b4c213c9af08 292 Gene3D G3DSA:3.20.20.190 57 287 1.6E-11 T 09-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 TK78_RS12120 6b9e62de54541f5f8df4527d89652a28 253 Pfam PF01738 Dienelactone hydrolase family 90 205 2.3E-6 T 09-03-2017 IPR002925 Dienelactone hydrolase GO:0016787 TK78_RS12120 6b9e62de54541f5f8df4527d89652a28 253 Gene3D G3DSA:3.40.50.1820 54 215 7.3E-20 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS12120 6b9e62de54541f5f8df4527d89652a28 253 SUPERFAMILY SSF53474 52 215 1.99E-23 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS17480 a06f30617cac089d7a853fb65df44c0f 239 Pfam PF05949 Bacterial protein of unknown function (DUF881) 83 236 1.7E-43 T 09-03-2017 IPR010273 Protein of unknown function DUF881 TK78_RS11970 6a6d873c721d6e36c73a7f0cbdb46ca5 399 Pfam PF16701 Adenylate cyclase regulatory domain 47 168 5.5E-8 T 09-03-2017 IPR032026 Adenylate cyclase regulatory domain TK78_RS11970 6a6d873c721d6e36c73a7f0cbdb46ca5 399 SMART SM00044 82 335 2.8E-4 T 09-03-2017 IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase GO:0009190|GO:0016849|GO:0035556 TK78_RS11970 6a6d873c721d6e36c73a7f0cbdb46ca5 399 Pfam PF00211 Adenylate and Guanylate cyclase catalytic domain 197 322 5.9E-14 T 09-03-2017 IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase GO:0009190|GO:0016849|GO:0035556 TK78_RS11970 6a6d873c721d6e36c73a7f0cbdb46ca5 399 Gene3D G3DSA:3.30.70.1230 196 325 1.0E-20 T 09-03-2017 IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase GO:0009190|GO:0016849|GO:0035556 TK78_RS11970 6a6d873c721d6e36c73a7f0cbdb46ca5 399 SUPERFAMILY SSF55073 195 328 6.28E-32 T 09-03-2017 IPR029787 Nucleotide cyclase TK78_RS14335 2a1daf900229b16474fdfa40d0238573 270 Gene3D G3DSA:1.10.357.10 37 264 6.5E-60 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS14335 2a1daf900229b16474fdfa40d0238573 270 Pfam PF00440 Bacterial regulatory proteins, tetR family 51 95 2.6E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS14335 2a1daf900229b16474fdfa40d0238573 270 SUPERFAMILY SSF48498 116 260 3.47E-23 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS14335 2a1daf900229b16474fdfa40d0238573 270 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 110 257 6.2E-27 T 09-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 TK78_RS14335 2a1daf900229b16474fdfa40d0238573 270 SUPERFAMILY SSF46689 40 106 3.85E-12 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS29985 5ce4feb6d7bc704f5f48abcf0f5d0838 273 Pfam PF01063 Amino-transferase class IV 29 242 3.2E-48 T 09-03-2017 IPR001544 Aminotransferase class IV GO:0003824|GO:0008152 Reactome: R-HSA-70895 TK78_RS29985 5ce4feb6d7bc704f5f48abcf0f5d0838 273 ProSitePatterns PS00770 Aminotransferases class-IV signature. 174 203 - T 09-03-2017 IPR018300 Aminotransferase, class IV, conserved site GO:0003824|GO:0008152 Reactome: R-HSA-70895 TK78_RS29985 5ce4feb6d7bc704f5f48abcf0f5d0838 273 Gene3D G3DSA:3.30.470.10 1 101 1.1E-31 T 09-03-2017 TK78_RS29985 5ce4feb6d7bc704f5f48abcf0f5d0838 273 SUPERFAMILY SSF56752 3 265 2.09E-69 T 09-03-2017 IPR001544 Aminotransferase class IV GO:0003824|GO:0008152 Reactome: R-HSA-70895 TK78_RS29985 5ce4feb6d7bc704f5f48abcf0f5d0838 273 Gene3D G3DSA:3.20.10.10 124 258 2.9E-41 T 09-03-2017 TK78_RS30800 a2e2e65d2e3bd1ae263cd2a0a461212a 124 SUPERFAMILY SSF50346 5 104 3.3E-23 T 09-03-2017 IPR011033 PRC-barrel-like TK78_RS30800 a2e2e65d2e3bd1ae263cd2a0a461212a 124 Gene3D G3DSA:2.30.30.240 9 46 6.8E-4 T 09-03-2017 TK78_RS30800 a2e2e65d2e3bd1ae263cd2a0a461212a 124 Pfam PF05239 PRC-barrel domain 8 71 1.7E-9 T 09-03-2017 IPR027275 PRC-barrel domain TK78_RS13260 478c86006958e91d893ff4a15dbbaaf4 299 Pfam PF02357 Transcription termination factor nusG 111 213 4.3E-22 T 09-03-2017 IPR006645 NusG, N-terminal GO:0006355 Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167200|Reactome: R-HSA-167238|Reactome: R-HSA-167242|Reactome: R-HSA-167243|Reactome: R-HSA-167246|Reactome: R-HSA-167287|Reactome: R-HSA-167290|Reactome: R-HSA-674695|Reactome: R-HSA-6796648|Reactome: R-HSA-72086|Reactome: R-HSA-75955|Reactome: R-HSA-77075 TK78_RS13260 478c86006958e91d893ff4a15dbbaaf4 299 ProSitePatterns PS01014 Transcription termination factor nusG signature. 282 291 - T 09-03-2017 IPR015869 Transcription antitermination protein, NusG, bacteria, conserved site TK78_RS13260 478c86006958e91d893ff4a15dbbaaf4 299 SUPERFAMILY SSF50104 244 298 5.21E-15 T 09-03-2017 IPR008991 Translation protein SH3-like domain TK78_RS13260 478c86006958e91d893ff4a15dbbaaf4 299 SMART SM00738 109 217 4.7E-48 T 09-03-2017 IPR006645 NusG, N-terminal GO:0006355 Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167200|Reactome: R-HSA-167238|Reactome: R-HSA-167242|Reactome: R-HSA-167243|Reactome: R-HSA-167246|Reactome: R-HSA-167287|Reactome: R-HSA-167290|Reactome: R-HSA-674695|Reactome: R-HSA-6796648|Reactome: R-HSA-72086|Reactome: R-HSA-75955|Reactome: R-HSA-77075 TK78_RS13260 478c86006958e91d893ff4a15dbbaaf4 299 PRINTS PR00338 Transcription termination factor NUSG signature 275 291 4.6E-18 T 09-03-2017 IPR001062 Transcription antitermination protein, NusG GO:0032784 TK78_RS13260 478c86006958e91d893ff4a15dbbaaf4 299 PRINTS PR00338 Transcription termination factor NUSG signature 257 272 4.6E-18 T 09-03-2017 IPR001062 Transcription antitermination protein, NusG GO:0032784 TK78_RS13260 478c86006958e91d893ff4a15dbbaaf4 299 PRINTS PR00338 Transcription termination factor NUSG signature 164 176 4.6E-18 T 09-03-2017 IPR001062 Transcription antitermination protein, NusG GO:0032784 TK78_RS13260 478c86006958e91d893ff4a15dbbaaf4 299 SMART SM00739 245 272 3.5E-4 T 09-03-2017 IPR005824 KOW TK78_RS13260 478c86006958e91d893ff4a15dbbaaf4 299 Hamap MF_00948 Transcription termination/antitermination protein NusG [nusG]. 109 299 22.415 T 09-03-2017 IPR001062 Transcription antitermination protein, NusG GO:0032784 TK78_RS13260 478c86006958e91d893ff4a15dbbaaf4 299 Gene3D G3DSA:3.30.70.940 111 219 1.9E-40 T 09-03-2017 IPR006645 NusG, N-terminal GO:0006355 Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167200|Reactome: R-HSA-167238|Reactome: R-HSA-167242|Reactome: R-HSA-167243|Reactome: R-HSA-167246|Reactome: R-HSA-167287|Reactome: R-HSA-167290|Reactome: R-HSA-674695|Reactome: R-HSA-6796648|Reactome: R-HSA-72086|Reactome: R-HSA-75955|Reactome: R-HSA-77075 TK78_RS13260 478c86006958e91d893ff4a15dbbaaf4 299 Gene3D G3DSA:2.30.30.30 244 298 2.1E-25 T 09-03-2017 IPR014722 Ribosomal protein L2 domain 2 TK78_RS13260 478c86006958e91d893ff4a15dbbaaf4 299 TIGRFAM TIGR00922 nusG: transcription termination/antitermination factor NusG 112 298 7.0E-53 T 09-03-2017 IPR001062 Transcription antitermination protein, NusG GO:0032784 TK78_RS13260 478c86006958e91d893ff4a15dbbaaf4 299 SUPERFAMILY SSF82679 111 217 7.85E-34 T 09-03-2017 IPR006645 NusG, N-terminal GO:0006355 Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167200|Reactome: R-HSA-167238|Reactome: R-HSA-167242|Reactome: R-HSA-167243|Reactome: R-HSA-167246|Reactome: R-HSA-167287|Reactome: R-HSA-167290|Reactome: R-HSA-674695|Reactome: R-HSA-6796648|Reactome: R-HSA-72086|Reactome: R-HSA-75955|Reactome: R-HSA-77075 TK78_RS25150 87c3763bb73767bac3f645831f30f6c7 229 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 86 191 1.2E-13 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS25150 87c3763bb73767bac3f645831f30f6c7 229 Gene3D G3DSA:3.40.50.1000 95 193 1.2E-36 T 09-03-2017 IPR023214 HAD-like domain TK78_RS25150 87c3763bb73767bac3f645831f30f6c7 229 Gene3D G3DSA:3.40.50.1000 4 22 1.2E-36 T 09-03-2017 IPR023214 HAD-like domain TK78_RS25150 87c3763bb73767bac3f645831f30f6c7 229 SUPERFAMILY SSF56784 10 194 2.21E-41 T 09-03-2017 IPR023214 HAD-like domain TK78_RS25150 87c3763bb73767bac3f645831f30f6c7 229 Pfam PF13419 Haloacid dehalogenase-like hydrolase 11 191 4.2E-25 T 09-03-2017 IPR023214 HAD-like domain TK78_RS16305 ebe23b28a4bf5611b2e86ab74a181564 134 Pfam PF03259 Roadblock/LC7 domain 8 96 4.2E-22 T 09-03-2017 IPR004942 Roadblock/LAMTOR2 domain TK78_RS16305 ebe23b28a4bf5611b2e86ab74a181564 134 Gene3D G3DSA:3.30.450.30 4 124 2.1E-24 T 09-03-2017 TK78_RS16305 ebe23b28a4bf5611b2e86ab74a181564 134 SMART SM00960 6 98 7.8E-22 T 09-03-2017 IPR004942 Roadblock/LAMTOR2 domain TK78_RS16305 ebe23b28a4bf5611b2e86ab74a181564 134 SUPERFAMILY SSF103196 4 127 1.7E-27 T 09-03-2017 TK78_RS33525 e267b0abc486cea034ef188ac8bd01b3 122 PIRSF PIRSF019455 1 121 2.1E-20 T 09-03-2017 IPR005650 BlaI transcriptional regulatory family GO:0003677|GO:0045892 TK78_RS33525 e267b0abc486cea034ef188ac8bd01b3 122 Gene3D G3DSA:1.10.10.10 1 79 8.0E-25 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS33525 e267b0abc486cea034ef188ac8bd01b3 122 SUPERFAMILY SSF46785 1 115 9.52E-25 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS33525 e267b0abc486cea034ef188ac8bd01b3 122 Pfam PF03965 Penicillinase repressor 4 114 2.6E-26 T 09-03-2017 IPR005650 BlaI transcriptional regulatory family GO:0003677|GO:0045892 TK78_RS33980 0aca968fe0fa41ee576c7ea82f5578a9 152 Gene3D G3DSA:3.30.565.10 36 88 7.1E-4 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS33980 0aca968fe0fa41ee576c7ea82f5578a9 152 SUPERFAMILY SSF55874 24 113 5.35E-8 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS23275 b7defcc5c796e32bf606f1b7ba573f4b 304 SUPERFAMILY SSF48452 113 279 1.74E-27 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS23275 b7defcc5c796e32bf606f1b7ba573f4b 304 Pfam PF03704 Bacterial transcriptional activator domain 118 263 3.5E-36 T 09-03-2017 IPR005158 Bacterial transcriptional activator domain TK78_RS23275 b7defcc5c796e32bf606f1b7ba573f4b 304 SMART SM01043 118 263 1.5E-41 T 09-03-2017 IPR005158 Bacterial transcriptional activator domain TK78_RS23275 b7defcc5c796e32bf606f1b7ba573f4b 304 SMART SM00862 29 111 1.8E-10 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS23275 b7defcc5c796e32bf606f1b7ba573f4b 304 Gene3D G3DSA:1.10.10.10 35 114 2.6E-10 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS23275 b7defcc5c796e32bf606f1b7ba573f4b 304 Pfam PF00486 Transcriptional regulatory protein, C terminal 34 110 1.3E-9 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS23275 b7defcc5c796e32bf606f1b7ba573f4b 304 SUPERFAMILY SSF46894 13 111 2.32E-14 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS01680 f7485be5c9700fec6ea896caf99c8eda 596 ProSitePatterns PS00211 ABC transporters family signature. 483 497 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS01680 f7485be5c9700fec6ea896caf99c8eda 596 SUPERFAMILY SSF90123 12 322 1.96E-37 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS01680 f7485be5c9700fec6ea896caf99c8eda 596 SMART SM00382 365 557 4.6E-13 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS01680 f7485be5c9700fec6ea896caf99c8eda 596 Gene3D G3DSA:3.40.50.300 342 584 4.1E-66 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01680 f7485be5c9700fec6ea896caf99c8eda 596 SUPERFAMILY SSF52540 332 578 1.56E-68 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01680 f7485be5c9700fec6ea896caf99c8eda 596 Pfam PF00005 ABC transporter 356 511 4.8E-25 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS01680 f7485be5c9700fec6ea896caf99c8eda 596 Gene3D G3DSA:1.20.1560.10 13 318 5.6E-32 T 09-03-2017 TK78_RS01680 f7485be5c9700fec6ea896caf99c8eda 596 Pfam PF00664 ABC transporter transmembrane region 65 274 1.2E-10 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS07195 fca325168d74cc56343e64e8d2a8ad7c 456 Gene3D G3DSA:3.30.830.10 22 230 3.3E-35 T 09-03-2017 IPR011237 Peptidase M16 domain GO:0046872 TK78_RS07195 fca325168d74cc56343e64e8d2a8ad7c 456 SUPERFAMILY SSF63411 14 224 4.58E-39 T 09-03-2017 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 TK78_RS07195 fca325168d74cc56343e64e8d2a8ad7c 456 Gene3D G3DSA:3.30.830.10 247 436 2.5E-12 T 09-03-2017 IPR011237 Peptidase M16 domain GO:0046872 TK78_RS07195 fca325168d74cc56343e64e8d2a8ad7c 456 Pfam PF00675 Insulinase (Peptidase family M16) 33 166 1.5E-13 T 09-03-2017 IPR011765 Peptidase M16, N-terminal TK78_RS07195 fca325168d74cc56343e64e8d2a8ad7c 456 SUPERFAMILY SSF63411 240 454 2.02E-20 T 09-03-2017 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 TK78_RS07195 fca325168d74cc56343e64e8d2a8ad7c 456 Pfam PF05193 Peptidase M16 inactive domain 185 369 4.3E-22 T 09-03-2017 IPR007863 Peptidase M16, C-terminal TK78_RS09015 189930f124119bf286a42b64824afa21 380 SUPERFAMILY SSF56645 72 230 1.57E-35 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS09015 189930f124119bf286a42b64824afa21 380 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 237 371 2.9E-14 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS09015 189930f124119bf286a42b64824afa21 380 Gene3D G3DSA:1.10.540.10 72 124 1.1E-6 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS09015 189930f124119bf286a42b64824afa21 380 Gene3D G3DSA:1.20.140.10 222 369 3.0E-20 T 09-03-2017 TK78_RS09015 189930f124119bf286a42b64824afa21 380 SUPERFAMILY SSF47203 237 370 1.77E-17 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS09015 189930f124119bf286a42b64824afa21 380 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 129 220 4.6E-14 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS09015 189930f124119bf286a42b64824afa21 380 Gene3D G3DSA:2.40.110.10 129 221 2.5E-23 T 09-03-2017 TK78_RS16370 51978a73705c583680bc97e3c0702560 256 Pfam PF01510 N-acetylmuramoyl-L-alanine amidase 71 222 5.2E-12 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS16370 51978a73705c583680bc97e3c0702560 256 Gene3D G3DSA:3.40.80.10 42 239 9.1E-49 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS16370 51978a73705c583680bc97e3c0702560 256 SMART SM00701 46 194 2.0E-49 T 09-03-2017 IPR006619 Peptidoglycan recognition protein family domain, metazoa/bacteria GO:0008270|GO:0008745|GO:0009253 TK78_RS16370 51978a73705c583680bc97e3c0702560 256 SUPERFAMILY SSF55846 46 235 1.44E-47 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS16370 51978a73705c583680bc97e3c0702560 256 SMART SM00644 60 222 9.3E-4 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS05740 25d8f178ec5b5f58a9a3835cf98f8d44 759 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 133 145 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS05740 25d8f178ec5b5f58a9a3835cf98f8d44 759 Pfam PF13458 Periplasmic binding protein 378 746 2.8E-34 T 09-03-2017 IPR028081 Leucine-binding protein domain TK78_RS05740 25d8f178ec5b5f58a9a3835cf98f8d44 759 Pfam PF00069 Protein kinase domain 18 274 4.8E-34 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS05740 25d8f178ec5b5f58a9a3835cf98f8d44 759 Gene3D G3DSA:1.10.510.10 98 276 5.6E-32 T 09-03-2017 TK78_RS05740 25d8f178ec5b5f58a9a3835cf98f8d44 759 Gene3D G3DSA:3.40.50.2300 377 561 2.9E-25 T 09-03-2017 TK78_RS05740 25d8f178ec5b5f58a9a3835cf98f8d44 759 Gene3D G3DSA:3.40.50.2300 562 663 6.2E-14 T 09-03-2017 TK78_RS05740 25d8f178ec5b5f58a9a3835cf98f8d44 759 SUPERFAMILY SSF56112 12 277 2.29E-58 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS05740 25d8f178ec5b5f58a9a3835cf98f8d44 759 SUPERFAMILY SSF53822 376 669 8.07E-46 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS05740 25d8f178ec5b5f58a9a3835cf98f8d44 759 SUPERFAMILY SSF53822 701 752 8.07E-46 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS05740 25d8f178ec5b5f58a9a3835cf98f8d44 759 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 21 43 - T 09-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 TK78_RS05740 25d8f178ec5b5f58a9a3835cf98f8d44 759 SMART SM00220 15 281 1.1E-42 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS05740 25d8f178ec5b5f58a9a3835cf98f8d44 759 Gene3D G3DSA:3.30.200.20 9 93 1.4E-13 T 09-03-2017 TK78_RS09930 3e5504c253f306e69ac54a77af03ca9d 960 Pfam PF13360 PQQ-like domain 819 949 9.8E-10 T 09-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat TK78_RS09930 3e5504c253f306e69ac54a77af03ca9d 960 Pfam PF13360 PQQ-like domain 599 663 1.5E-5 T 09-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat TK78_RS09930 3e5504c253f306e69ac54a77af03ca9d 960 Gene3D G3DSA:2.140.10.10 532 958 1.2E-28 T 09-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain TK78_RS09930 3e5504c253f306e69ac54a77af03ca9d 960 SUPERFAMILY SSF50998 574 646 1.96E-17 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS09930 3e5504c253f306e69ac54a77af03ca9d 960 SUPERFAMILY SSF50998 777 923 1.96E-17 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS09930 3e5504c253f306e69ac54a77af03ca9d 960 Gene3D G3DSA:1.10.510.10 109 269 1.0E-19 T 09-03-2017 TK78_RS09930 3e5504c253f306e69ac54a77af03ca9d 960 SMART SM00220 15 273 1.9E-5 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS09930 3e5504c253f306e69ac54a77af03ca9d 960 SUPERFAMILY SSF56112 9 269 4.16E-24 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS09930 3e5504c253f306e69ac54a77af03ca9d 960 Pfam PF00069 Protein kinase domain 102 267 5.2E-12 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS09430 26d18ebeb36a40dcf126834fda47fe2e 323 Pfam PF14559 Tetratricopeptide repeat 197 232 2.8E-7 T 09-03-2017 TK78_RS09430 26d18ebeb36a40dcf126834fda47fe2e 323 Gene3D G3DSA:3.40.30.10 49 155 4.6E-28 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS09430 26d18ebeb36a40dcf126834fda47fe2e 323 Gene3D G3DSA:1.25.40.10 240 323 1.6E-13 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS09430 26d18ebeb36a40dcf126834fda47fe2e 323 Pfam PF00085 Thioredoxin 50 152 3.9E-23 T 09-03-2017 IPR013766 Thioredoxin domain GO:0045454 TK78_RS09430 26d18ebeb36a40dcf126834fda47fe2e 323 Pfam PF14561 Tetratricopeptide repeat 237 323 2.0E-23 T 09-03-2017 TK78_RS09430 26d18ebeb36a40dcf126834fda47fe2e 323 ProSitePatterns PS00194 Thioredoxin family active site. 71 89 - T 09-03-2017 IPR017937 Thioredoxin, conserved site GO:0045454 TK78_RS09430 26d18ebeb36a40dcf126834fda47fe2e 323 SUPERFAMILY SSF48452 179 321 1.57E-5 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS09430 26d18ebeb36a40dcf126834fda47fe2e 323 SUPERFAMILY SSF52833 49 156 5.39E-30 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS09430 26d18ebeb36a40dcf126834fda47fe2e 323 Gene3D G3DSA:1.25.40.10 186 231 1.8E-5 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS03350 0ed6469f12b097e18711f1d94563dba1 98 SUPERFAMILY SSF54909 1 83 2.68E-18 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS03350 0ed6469f12b097e18711f1d94563dba1 98 Gene3D G3DSA:3.30.70.1060 12 82 3.3E-9 T 09-03-2017 TK78_RS03350 0ed6469f12b097e18711f1d94563dba1 98 Pfam PF03795 YCII-related domain 1 81 4.6E-17 T 09-03-2017 IPR005545 YCII-related TK78_RS10280 c4af2cac972f153ed4224efe60646927 509 Pfam PF00933 Glycosyl hydrolase family 3 N terminal domain 40 329 7.8E-77 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS10280 c4af2cac972f153ed4224efe60646927 509 Gene3D G3DSA:3.20.20.300 19 336 1.4E-96 T 09-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TK78_RS10280 c4af2cac972f153ed4224efe60646927 509 SUPERFAMILY SSF51445 22 335 2.84E-82 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS18060 f7b4bc8807b402c0c20cde601da6ec5c 316 SUPERFAMILY SSF103481 190 286 1.83E-11 T 09-03-2017 TK78_RS18060 f7b4bc8807b402c0c20cde601da6ec5c 316 Pfam PF00892 EamA-like transporter family 150 285 2.0E-17 T 09-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 TK78_RS18060 f7b4bc8807b402c0c20cde601da6ec5c 316 Pfam PF00892 EamA-like transporter family 11 137 1.1E-19 T 09-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 TK78_RS18060 f7b4bc8807b402c0c20cde601da6ec5c 316 SUPERFAMILY SSF103481 39 140 3.53E-12 T 09-03-2017 TK78_RS19335 ca0dacb6b8036e1e227e5381c81106de 148 SMART SM00347 25 123 1.7E-7 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS19335 ca0dacb6b8036e1e227e5381c81106de 148 SUPERFAMILY SSF46785 23 134 1.44E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS19335 ca0dacb6b8036e1e227e5381c81106de 148 PRINTS PR00598 Bacterial regulatory protein MarR family signature 113 133 1.8E-5 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS19335 ca0dacb6b8036e1e227e5381c81106de 148 PRINTS PR00598 Bacterial regulatory protein MarR family signature 47 63 1.8E-5 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS19335 ca0dacb6b8036e1e227e5381c81106de 148 PRINTS PR00598 Bacterial regulatory protein MarR family signature 64 79 1.8E-5 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS19335 ca0dacb6b8036e1e227e5381c81106de 148 Pfam PF01047 MarR family 34 83 6.3E-8 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS19335 ca0dacb6b8036e1e227e5381c81106de 148 Gene3D G3DSA:1.10.10.10 14 134 2.4E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS19595 5b4d299a051a1ce8e8994bb943908280 121 Hamap MF_00338 UPF0145 protein YbjQ [ybjQ]. 16 118 21.842 T 09-03-2017 IPR002765 Uncharacterised protein family UPF0145 TK78_RS19595 5b4d299a051a1ce8e8994bb943908280 121 Gene3D G3DSA:3.30.110.70 17 117 2.3E-32 T 09-03-2017 IPR002765 Uncharacterised protein family UPF0145 TK78_RS19595 5b4d299a051a1ce8e8994bb943908280 121 SUPERFAMILY SSF117782 17 118 1.14E-31 T 09-03-2017 IPR002765 Uncharacterised protein family UPF0145 TK78_RS19595 5b4d299a051a1ce8e8994bb943908280 121 Pfam PF01906 Putative heavy-metal-binding 16 117 2.3E-33 T 09-03-2017 IPR002765 Uncharacterised protein family UPF0145 TK78_RS03045 7e815f00fd79126b0476e14d7de950d3 253 ProSitePatterns PS00552 MerR-type HTH domain signature. 6 28 - T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS03045 7e815f00fd79126b0476e14d7de950d3 253 SUPERFAMILY SSF89082 165 248 5.89E-11 T 09-03-2017 IPR012925 TipAS antibiotic-recognition domain TK78_RS03045 7e815f00fd79126b0476e14d7de950d3 253 SUPERFAMILY SSF46955 3 108 4.03E-27 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS03045 7e815f00fd79126b0476e14d7de950d3 253 Gene3D G3DSA:1.10.490.50 165 250 5.4E-15 T 09-03-2017 IPR012925 TipAS antibiotic-recognition domain TK78_RS03045 7e815f00fd79126b0476e14d7de950d3 253 Pfam PF07739 TipAS antibiotic-recognition domain 147 247 1.2E-13 T 09-03-2017 IPR012925 TipAS antibiotic-recognition domain TK78_RS03045 7e815f00fd79126b0476e14d7de950d3 253 Gene3D G3DSA:1.10.1660.10 4 112 3.3E-28 T 09-03-2017 TK78_RS03045 7e815f00fd79126b0476e14d7de950d3 253 SMART SM00422 3 72 1.2E-24 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS03045 7e815f00fd79126b0476e14d7de950d3 253 Pfam PF13411 MerR HTH family regulatory protein 5 70 9.2E-19 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS32790 2b8f35df368f92bbba5a8f11e4320e7f 412 Pfam PF07730 Histidine kinase 198 263 2.3E-20 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS32790 2b8f35df368f92bbba5a8f11e4320e7f 412 Gene3D G3DSA:3.30.565.10 282 398 3.8E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS32790 2b8f35df368f92bbba5a8f11e4320e7f 412 SUPERFAMILY SSF55874 279 394 4.68E-16 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS25935 2eba6be2d1cda506863daf36c8cdf831 216 Pfam PF13578 Methyltransferase domain 45 173 2.2E-21 T 09-03-2017 TK78_RS25935 2eba6be2d1cda506863daf36c8cdf831 216 SUPERFAMILY SSF53335 43 201 4.59E-14 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS25935 2eba6be2d1cda506863daf36c8cdf831 216 Gene3D G3DSA:3.40.50.150 44 176 5.1E-12 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS05410 63365c2a276e90187e99249f360c2854 319 SUPERFAMILY SSF100950 12 303 8.9E-78 T 09-03-2017 TK78_RS05410 63365c2a276e90187e99249f360c2854 319 Gene3D G3DSA:3.40.1080.10 13 130 2.3E-90 T 09-03-2017 TK78_RS05410 63365c2a276e90187e99249f360c2854 319 Gene3D G3DSA:3.40.1080.10 173 305 2.3E-90 T 09-03-2017 TK78_RS05410 63365c2a276e90187e99249f360c2854 319 Pfam PF01144 Coenzyme A transferase 14 239 7.7E-31 T 09-03-2017 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 TK78_RS05410 63365c2a276e90187e99249f360c2854 319 SMART SM00882 14 241 9.7E-42 T 09-03-2017 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 TK78_RS15735 0eeb608cdedad3bf151a2f85f093a70b 213 Gene3D G3DSA:3.40.50.880 8 186 9.3E-30 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS15735 0eeb608cdedad3bf151a2f85f093a70b 213 SUPERFAMILY SSF52317 8 184 7.45E-26 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS15735 0eeb608cdedad3bf151a2f85f093a70b 213 Pfam PF01965 DJ-1/PfpI family 9 155 6.1E-23 T 09-03-2017 IPR002818 DJ-1/PfpI TK78_RS19075 a0bfa7561af2171531debebbc32dfcd8 160 SMART SM01058 2 112 1.2E-32 T 09-03-2017 IPR003711 CarD-like/TRCF domain TK78_RS19075 a0bfa7561af2171531debebbc32dfcd8 160 SUPERFAMILY SSF141259 2 65 3.66E-15 T 09-03-2017 IPR003711 CarD-like/TRCF domain TK78_RS19075 a0bfa7561af2171531debebbc32dfcd8 160 Pfam PF02559 CarD-like/TRCF domain 3 110 1.4E-15 T 09-03-2017 IPR003711 CarD-like/TRCF domain TK78_RS25205 2441992a8ce98a35aedfcf467d764cea 267 SUPERFAMILY SSF56752 25 248 4.58E-33 T 09-03-2017 IPR001544 Aminotransferase class IV GO:0003824|GO:0008152 Reactome: R-HSA-70895 TK78_RS25205 2441992a8ce98a35aedfcf467d764cea 267 Pfam PF01063 Amino-transferase class IV 31 240 4.2E-22 T 09-03-2017 IPR001544 Aminotransferase class IV GO:0003824|GO:0008152 Reactome: R-HSA-70895 TK78_RS25205 2441992a8ce98a35aedfcf467d764cea 267 Gene3D G3DSA:3.30.470.10 27 98 4.7E-6 T 09-03-2017 TK78_RS25205 2441992a8ce98a35aedfcf467d764cea 267 Gene3D G3DSA:3.20.10.10 116 256 2.4E-13 T 09-03-2017 TK78_RS05695 35f74d07005ecad9cd1d7809680b34be 130 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 4 124 4.5E-17 T 09-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain TK78_RS05695 35f74d07005ecad9cd1d7809680b34be 130 Gene3D G3DSA:3.10.180.10 2 128 3.8E-25 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS05695 35f74d07005ecad9cd1d7809680b34be 130 SUPERFAMILY SSF54593 3 129 1.18E-28 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS06590 76d03cff3cb781b1accace6957025513 486 Gene3D G3DSA:3.90.230.10 218 479 1.6E-60 T 09-03-2017 IPR000994 Peptidase M24, structural domain TK78_RS06590 76d03cff3cb781b1accace6957025513 486 Pfam PF05195 Aminopeptidase P, N-terminal domain 49 166 3.2E-18 T 09-03-2017 IPR007865 Aminopeptidase P, N-terminal GO:0004177|GO:0030145 TK78_RS06590 76d03cff3cb781b1accace6957025513 486 SUPERFAMILY SSF53092 49 213 8.37E-25 T 09-03-2017 IPR028980 Creatinase/Aminopeptidase P, N-terminal TK78_RS06590 76d03cff3cb781b1accace6957025513 486 SMART SM01011 42 186 1.2E-35 T 09-03-2017 IPR007865 Aminopeptidase P, N-terminal GO:0004177|GO:0030145 TK78_RS06590 76d03cff3cb781b1accace6957025513 486 Gene3D G3DSA:3.40.350.10 48 217 1.7E-31 T 09-03-2017 IPR029149 Creatinase/Aminopeptidase P/Spt16, N-terminal TK78_RS06590 76d03cff3cb781b1accace6957025513 486 Pfam PF00557 Metallopeptidase family M24 234 459 3.2E-46 T 09-03-2017 IPR000994 Peptidase M24, structural domain TK78_RS06590 76d03cff3cb781b1accace6957025513 486 SUPERFAMILY SSF55920 214 480 2.09E-57 T 09-03-2017 IPR000994 Peptidase M24, structural domain TK78_RS26525 3116a51fe089fdd81657609800be2973 177 Pfam PF07931 Chloramphenicol phosphotransferase-like protein 4 176 5.7E-62 T 09-03-2017 IPR012853 Chloramphenicol phosphotransferase-like GO:0005524|GO:0016740 TK78_RS26525 3116a51fe089fdd81657609800be2973 177 Gene3D G3DSA:3.40.50.300 3 175 1.7E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS26525 3116a51fe089fdd81657609800be2973 177 ProSitePatterns PS01075 Acetate and butyrate kinases family signature 1. 5 16 - T 09-03-2017 IPR023865 Aliphatic acid kinase, short-chain, conserved site GO:0008152|GO:0016301|GO:0016310|GO:0016774 KEGG: 00430+2.7.2.1|KEGG: 00620+2.7.2.1|KEGG: 00640+2.7.2.1|KEGG: 00680+2.7.2.1|KEGG: 00720+2.7.2.1|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497 TK78_RS26525 3116a51fe089fdd81657609800be2973 177 SUPERFAMILY SSF52540 4 167 1.24E-10 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS26525 3116a51fe089fdd81657609800be2973 177 PIRSF PIRSF007531 1 177 5.4E-65 T 09-03-2017 IPR012853 Chloramphenicol phosphotransferase-like GO:0005524|GO:0016740 TK78_RS23800 c0ec45d7fae4f51ce826d0a5ff0bef3d 278 Gene3D G3DSA:3.20.20.150 12 276 2.4E-75 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS23800 c0ec45d7fae4f51ce826d0a5ff0bef3d 278 SUPERFAMILY SSF51658 9 273 1.1E-59 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS23800 c0ec45d7fae4f51ce826d0a5ff0bef3d 278 Pfam PF01261 Xylose isomerase-like TIM barrel 30 212 7.6E-31 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS05225 a71e04d5111b8a0f580f197be28dcd4a 243 Gene3D G3DSA:3.40.109.10 19 78 6.8E-37 T 09-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TK78_RS05225 a71e04d5111b8a0f580f197be28dcd4a 243 Gene3D G3DSA:3.40.109.10 111 243 6.8E-37 T 09-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TK78_RS05225 a71e04d5111b8a0f580f197be28dcd4a 243 Pfam PF00881 Nitroreductase family 26 221 2.1E-19 T 09-03-2017 IPR029479 Nitroreductase Reactome: R-HSA-209968 TK78_RS05225 a71e04d5111b8a0f580f197be28dcd4a 243 SUPERFAMILY SSF55469 111 243 2.54E-39 T 09-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TK78_RS05225 a71e04d5111b8a0f580f197be28dcd4a 243 SUPERFAMILY SSF55469 18 78 2.54E-39 T 09-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TK78_RS27600 ff7d8986b905608d13d051eae2cb40fe 218 Pfam PF03861 ANTAR domain 155 207 7.3E-20 T 09-03-2017 IPR005561 ANTAR domain GO:0003723 TK78_RS27600 ff7d8986b905608d13d051eae2cb40fe 218 SMART SM00448 25 136 3.7E-38 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS27600 ff7d8986b905608d13d051eae2cb40fe 218 SUPERFAMILY SSF52172 24 207 2.99E-55 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS27600 ff7d8986b905608d13d051eae2cb40fe 218 Gene3D G3DSA:1.10.10.10 154 211 7.1E-24 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS27600 ff7d8986b905608d13d051eae2cb40fe 218 SMART SM01012 152 207 1.2E-22 T 09-03-2017 IPR005561 ANTAR domain GO:0003723 TK78_RS27600 ff7d8986b905608d13d051eae2cb40fe 218 PIRSF PIRSF036382 17 214 1.8E-70 T 09-03-2017 IPR008327 Signal transduction response regulator, antiterminator TK78_RS27600 ff7d8986b905608d13d051eae2cb40fe 218 Gene3D G3DSA:3.40.50.2300 24 145 7.2E-38 T 09-03-2017 TK78_RS27600 ff7d8986b905608d13d051eae2cb40fe 218 Pfam PF00072 Response regulator receiver domain 27 136 1.7E-29 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS24590 8e26566f5fc3b7c1de6957c4c9447cb9 205 SUPERFAMILY SSF52374 12 204 9.38E-55 T 09-03-2017 TK78_RS24590 8e26566f5fc3b7c1de6957c4c9447cb9 205 Pfam PF01467 Cytidylyltransferase-like 17 177 3.0E-29 T 09-03-2017 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 TK78_RS24590 8e26566f5fc3b7c1de6957c4c9447cb9 205 TIGRFAM TIGR00482 TIGR00482: nicotinate (nicotinamide) nucleotide adenylyltransferase 17 202 7.5E-55 T 09-03-2017 IPR005248 Probable nicotinate-nucleotide adenylyltransferase GO:0009435|GO:0016779 KEGG: 00760+2.7.7.18|MetaCyc: PWY-5381|MetaCyc: PWY-5653|Reactome: R-HSA-196807 TK78_RS24590 8e26566f5fc3b7c1de6957c4c9447cb9 205 Gene3D G3DSA:3.40.50.620 13 204 9.3E-66 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS24590 8e26566f5fc3b7c1de6957c4c9447cb9 205 TIGRFAM TIGR00125 cyt_tran_rel: cytidyltransferase-like domain 15 79 4.2E-11 T 09-03-2017 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 TK78_RS24590 8e26566f5fc3b7c1de6957c4c9447cb9 205 Hamap MF_00244 Probable nicotinate-nucleotide adenylyltransferase [nadD]. 13 203 30.72 T 09-03-2017 IPR005248 Probable nicotinate-nucleotide adenylyltransferase GO:0009435|GO:0016779 KEGG: 00760+2.7.7.18|MetaCyc: PWY-5381|MetaCyc: PWY-5653|Reactome: R-HSA-196807 TK78_RS22230 4fbde48890f4c8975e1f97ed2564f026 1273 Gene3D G3DSA:3.40.50.300 1096 1167 1.8E-8 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22230 4fbde48890f4c8975e1f97ed2564f026 1273 Gene3D G3DSA:3.40.50.300 939 1023 1.8E-8 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22230 4fbde48890f4c8975e1f97ed2564f026 1273 Pfam PF16697 Inner membrane component of T3SS, cytoplasmic domain 103 193 2.3E-16 T 09-03-2017 IPR032030 YscD, cytoplasmic domain TK78_RS22230 4fbde48890f4c8975e1f97ed2564f026 1273 SMART SM00240 119 170 2.1E-11 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS22230 4fbde48890f4c8975e1f97ed2564f026 1273 SMART SM00382 942 1175 1.4E-8 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS22230 4fbde48890f4c8975e1f97ed2564f026 1273 SUPERFAMILY SSF49879 96 203 1.21E-24 T 09-03-2017 IPR008984 SMAD/FHA domain GO:0005515 TK78_RS22230 4fbde48890f4c8975e1f97ed2564f026 1273 Gene3D G3DSA:2.60.200.20 95 193 3.2E-24 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS22230 4fbde48890f4c8975e1f97ed2564f026 1273 SUPERFAMILY SSF52540 921 1158 1.54E-13 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22230 4fbde48890f4c8975e1f97ed2564f026 1273 Pfam PF01580 FtsK/SpoIIIE family 932 1050 8.6E-13 T 09-03-2017 IPR002543 FtsK domain GO:0000166|GO:0003677|GO:0005524 TK78_RS22930 fcddf7824641571ab775467496add28b 376 Gene3D G3DSA:3.40.50.720 11 142 2.7E-38 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS22930 fcddf7824641571ab775467496add28b 376 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 147 229 4.0E-12 T 09-03-2017 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 TK78_RS22930 fcddf7824641571ab775467496add28b 376 SUPERFAMILY SSF51735 9 169 7.55E-45 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS22930 fcddf7824641571ab775467496add28b 376 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 13 132 5.0E-23 T 09-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 TK78_RS22930 fcddf7824641571ab775467496add28b 376 Gene3D G3DSA:3.30.360.10 143 359 1.2E-37 T 09-03-2017 TK78_RS22930 fcddf7824641571ab775467496add28b 376 SUPERFAMILY SSF55347 141 290 9.32E-27 T 09-03-2017 TK78_RS15985 c2442ea94928a498d823e17417895935 393 Gene3D G3DSA:3.90.1150.10 239 381 1.1E-43 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS15985 c2442ea94928a498d823e17417895935 393 Gene3D G3DSA:3.40.640.10 47 238 6.3E-44 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS15985 c2442ea94928a498d823e17417895935 393 SUPERFAMILY SSF53383 5 385 3.67E-84 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS15985 c2442ea94928a498d823e17417895935 393 Pfam PF00155 Aminotransferase class I and II 36 379 1.3E-43 T 09-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TK78_RS14325 d7537816008a636262acb86e6180d2a6 290 PIRSF PIRSF006648 18 290 1.1E-65 T 09-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 TK78_RS14325 d7537816008a636262acb86e6180d2a6 290 Pfam PF01061 ABC-2 type transporter 38 245 3.5E-27 T 09-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 TK78_RS18470 4992587ad013dd02c3260fae1939b367 284 Pfam PF00440 Bacterial regulatory proteins, tetR family 67 110 5.9E-13 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS18470 4992587ad013dd02c3260fae1939b367 284 Gene3D G3DSA:1.10.357.10 221 283 1.1E-61 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS18470 4992587ad013dd02c3260fae1939b367 284 Gene3D G3DSA:1.10.357.10 54 180 1.1E-61 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS18470 4992587ad013dd02c3260fae1939b367 284 SUPERFAMILY SSF46689 54 135 4.14E-16 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS18470 4992587ad013dd02c3260fae1939b367 284 SUPERFAMILY SSF48498 220 281 6.15E-11 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS18470 4992587ad013dd02c3260fae1939b367 284 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 86 109 1.0E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS18470 4992587ad013dd02c3260fae1939b367 284 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 66 79 1.0E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS30475 01a7872db154bba420a01e3f14def1c1 161 TIGRFAM TIGR00114 lumazine-synth: 6,7-dimethyl-8-ribityllumazine synthase 17 151 1.4E-41 T 09-03-2017 IPR002180 6,7-dimethyl-8-ribityllumazine synthase GO:0009231|GO:0009349 KEGG: 00740+2.5.1.78|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TK78_RS30475 01a7872db154bba420a01e3f14def1c1 161 SUPERFAMILY SSF52121 11 156 8.63E-54 T 09-03-2017 IPR002180 6,7-dimethyl-8-ribityllumazine synthase GO:0009231|GO:0009349 KEGG: 00740+2.5.1.78|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TK78_RS30475 01a7872db154bba420a01e3f14def1c1 161 Pfam PF00885 6,7-dimethyl-8-ribityllumazine synthase 17 152 7.3E-50 T 09-03-2017 IPR002180 6,7-dimethyl-8-ribityllumazine synthase GO:0009231|GO:0009349 KEGG: 00740+2.5.1.78|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TK78_RS30475 01a7872db154bba420a01e3f14def1c1 161 Hamap MF_00178 6,7-dimethyl-8-ribityllumazine synthase [ribH]. 12 156 28.27 T 09-03-2017 IPR002180 6,7-dimethyl-8-ribityllumazine synthase GO:0009231|GO:0009349 KEGG: 00740+2.5.1.78|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TK78_RS30475 01a7872db154bba420a01e3f14def1c1 161 Gene3D G3DSA:3.40.50.960 13 157 1.9E-56 T 09-03-2017 IPR002180 6,7-dimethyl-8-ribityllumazine synthase GO:0009231|GO:0009349 KEGG: 00740+2.5.1.78|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TK78_RS02690 5f4d843d7e82e67003e5b90285f34455 177 Gene3D G3DSA:1.10.10.10 1 86 3.3E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS02690 5f4d843d7e82e67003e5b90285f34455 177 Pfam PF10400 Virulence activator alpha C-term 92 174 1.5E-23 T 09-03-2017 IPR018309 Transcription regulator PadR, C-terminal TK78_RS02690 5f4d843d7e82e67003e5b90285f34455 177 Pfam PF03551 Transcriptional regulator PadR-like family 7 80 7.1E-9 T 09-03-2017 IPR005149 Transcription regulator PadR, N-terminal TK78_RS02690 5f4d843d7e82e67003e5b90285f34455 177 SUPERFAMILY SSF46785 2 176 6.36E-35 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS22405 5d2f7f408b8b9af88323a4f6ca20f4a0 298 SUPERFAMILY SSF55447 181 232 1.88E-5 T 09-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal TK78_RS22405 5d2f7f408b8b9af88323a4f6ca20f4a0 298 Gene3D G3DSA:3.30.390.50 182 261 5.0E-5 T 09-03-2017 TK78_RS22405 5d2f7f408b8b9af88323a4f6ca20f4a0 298 Gene3D G3DSA:3.30.465.10 62 175 2.3E-27 T 09-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 TK78_RS22405 5d2f7f408b8b9af88323a4f6ca20f4a0 298 Gene3D G3DSA:3.30.43.10 15 55 1.4E-8 T 09-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 TK78_RS22405 5d2f7f408b8b9af88323a4f6ca20f4a0 298 SUPERFAMILY SSF56176 10 175 1.02E-39 T 09-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 TK78_RS22405 5d2f7f408b8b9af88323a4f6ca20f4a0 298 Pfam PF00941 FAD binding domain in molybdopterin dehydrogenase 12 175 4.4E-40 T 09-03-2017 IPR002346 Molybdopterin dehydrogenase, FAD-binding GO:0016491|GO:0055114 TK78_RS29075 637bcd6d7fc4a7725215cd455e37ca51 255 SUPERFAMILY SSF51735 4 249 1.45E-50 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS29075 637bcd6d7fc4a7725215cd455e37ca51 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 72 83 2.1E-21 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS29075 637bcd6d7fc4a7725215cd455e37ca51 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 144 163 2.1E-21 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS29075 637bcd6d7fc4a7725215cd455e37ca51 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 2.1E-21 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS29075 637bcd6d7fc4a7725215cd455e37ca51 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 118 134 2.1E-21 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS29075 637bcd6d7fc4a7725215cd455e37ca51 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 165 182 2.1E-21 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS29075 637bcd6d7fc4a7725215cd455e37ca51 255 Gene3D G3DSA:3.40.50.720 9 215 9.5E-47 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS29075 637bcd6d7fc4a7725215cd455e37ca51 255 Pfam PF00106 short chain dehydrogenase 9 185 1.8E-35 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS29075 637bcd6d7fc4a7725215cd455e37ca51 255 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 131 159 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS04535 6962129bffd9a6d734e3266ed74eeb6c 468 Pfam PF13434 L-lysine 6-monooxygenase (NADPH-requiring) 10 353 4.7E-107 T 09-03-2017 IPR025700 L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase TK78_RS04535 6962129bffd9a6d734e3266ed74eeb6c 468 Gene3D G3DSA:3.50.50.60 95 221 5.9E-10 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS04535 6962129bffd9a6d734e3266ed74eeb6c 468 SUPERFAMILY SSF51905 8 259 9.62E-16 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS04535 6962129bffd9a6d734e3266ed74eeb6c 468 SUPERFAMILY SSF51905 202 240 4.92E-5 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS04535 6962129bffd9a6d734e3266ed74eeb6c 468 SUPERFAMILY SSF51905 289 383 4.92E-5 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS04535 6962129bffd9a6d734e3266ed74eeb6c 468 Gene3D G3DSA:3.50.50.60 15 54 5.0E-5 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS04535 6962129bffd9a6d734e3266ed74eeb6c 468 Gene3D G3DSA:3.50.50.60 277 387 5.0E-5 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS15470 2e2c9544d8db37da6a966c61d822b128 154 SUPERFAMILY SSF89095 3 152 5.02E-35 T 09-03-2017 IPR003789 Aspartyl/glutamyl-tRNA amidotransferase subunit B-related GO:0016884 TK78_RS15470 2e2c9544d8db37da6a966c61d822b128 154 Gene3D G3DSA:1.10.10.410 94 153 1.9E-18 T 09-03-2017 IPR023168 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, C-terminal TK78_RS15470 2e2c9544d8db37da6a966c61d822b128 154 Gene3D G3DSA:1.10.1510.10 3 93 2.2E-27 T 09-03-2017 TK78_RS15470 2e2c9544d8db37da6a966c61d822b128 154 Pfam PF09424 Yqey-like protein 5 152 2.9E-45 T 09-03-2017 IPR019004 Uncharacterised domain YOR215C, mitochondrial TK78_RS02965 0da516880b7ac7c6bd78292364fd4878 176 Pfam PF00583 Acetyltransferase (GNAT) family 63 134 2.7E-7 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS02965 0da516880b7ac7c6bd78292364fd4878 176 SUPERFAMILY SSF55729 14 139 6.2E-19 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS02965 0da516880b7ac7c6bd78292364fd4878 176 Gene3D G3DSA:3.40.630.30 13 140 4.6E-16 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS05020 896a7fd604d9737d8b7397b5152e0ca2 422 Gene3D G3DSA:3.40.190.10 165 353 4.8E-40 T 09-03-2017 TK78_RS05020 896a7fd604d9737d8b7397b5152e0ca2 422 Pfam PF01547 Bacterial extracellular solute-binding protein 49 335 6.2E-46 T 09-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 TK78_RS05020 896a7fd604d9737d8b7397b5152e0ca2 422 SUPERFAMILY SSF53850 19 415 1.2E-73 T 09-03-2017 TK78_RS05020 896a7fd604d9737d8b7397b5152e0ca2 422 Gene3D G3DSA:3.40.190.10 41 164 1.0E-18 T 09-03-2017 TK78_RS03375 5331a1a9e720b430d0976012736bb19e 74 Gene3D G3DSA:3.40.50.1820 12 70 5.3E-18 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS03375 5331a1a9e720b430d0976012736bb19e 74 Pfam PF12697 Alpha/beta hydrolase family 25 68 4.2E-8 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS03375 5331a1a9e720b430d0976012736bb19e 74 SUPERFAMILY SSF53474 12 72 1.25E-16 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS31350 f1ae2a4228883792afc51a5069a172e0 190 SUPERFAMILY SSF47413 9 74 2.52E-16 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS31350 f1ae2a4228883792afc51a5069a172e0 190 Pfam PF07883 Cupin domain 115 182 4.3E-15 T 09-03-2017 IPR013096 Cupin 2, conserved barrel TK78_RS31350 f1ae2a4228883792afc51a5069a172e0 190 SMART SM00530 14 69 2.9E-14 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS31350 f1ae2a4228883792afc51a5069a172e0 190 Gene3D G3DSA:2.60.120.10 98 188 3.9E-25 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS31350 f1ae2a4228883792afc51a5069a172e0 190 SUPERFAMILY SSF51182 62 184 2.32E-22 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS31350 f1ae2a4228883792afc51a5069a172e0 190 Pfam PF13560 Helix-turn-helix domain 11 65 1.7E-11 T 09-03-2017 TK78_RS31350 f1ae2a4228883792afc51a5069a172e0 190 Gene3D G3DSA:1.10.260.40 6 77 4.8E-20 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS07505 c54fffaa505634429cb7f68f33bea9e7 294 Gene3D G3DSA:3.40.50.720 1 253 1.3E-37 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07505 c54fffaa505634429cb7f68f33bea9e7 294 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 85 96 1.3E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS07505 c54fffaa505634429cb7f68f33bea9e7 294 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 1 16 1.3E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS07505 c54fffaa505634429cb7f68f33bea9e7 294 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 164 183 1.3E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS07505 c54fffaa505634429cb7f68f33bea9e7 294 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 185 202 1.3E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS07505 c54fffaa505634429cb7f68f33bea9e7 294 SUPERFAMILY SSF51735 1 253 1.83E-33 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS07505 c54fffaa505634429cb7f68f33bea9e7 294 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 8 242 1.2E-16 T 09-03-2017 TK78_RS16905 1d37187f95add4ed0bccdb447c0842ec 643 SUPERFAMILY SSF52540 192 288 3.93E-16 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS16905 1d37187f95add4ed0bccdb447c0842ec 643 SUPERFAMILY SSF52540 452 638 3.93E-16 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS16905 1d37187f95add4ed0bccdb447c0842ec 643 Gene3D G3DSA:3.40.50.300 204 284 5.7E-16 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS16905 1d37187f95add4ed0bccdb447c0842ec 643 Gene3D G3DSA:3.40.50.300 474 605 5.7E-16 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS16905 1d37187f95add4ed0bccdb447c0842ec 643 Pfam PF01935 Domain of unknown function DUF87 193 319 7.0E-11 T 09-03-2017 IPR002789 Helicase HerA, central domain TK78_RS10055 ac27d89bfa6d9d2652e395dc462d3c81 417 Pfam PF03949 Malic enzyme, NAD binding domain 192 391 8.4E-19 T 09-03-2017 IPR012302 Malic enzyme, NAD-binding GO:0004471|GO:0051287|GO:0055114 TK78_RS10055 ac27d89bfa6d9d2652e395dc462d3c81 417 SUPERFAMILY SSF51735 190 416 1.79E-66 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS10055 ac27d89bfa6d9d2652e395dc462d3c81 417 PIRSF PIRSF000106 45 417 6.4E-71 T 09-03-2017 IPR001891 Malic oxidoreductase GO:0004470|GO:0004471|GO:0006108|GO:0055114 TK78_RS10055 ac27d89bfa6d9d2652e395dc462d3c81 417 Gene3D G3DSA:3.40.50.720 188 416 1.3E-68 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS10055 ac27d89bfa6d9d2652e395dc462d3c81 417 SMART SM01274 45 178 5.4E-78 T 09-03-2017 IPR012301 Malic enzyme, N-terminal domain GO:0004471|GO:0055114 TK78_RS10055 ac27d89bfa6d9d2652e395dc462d3c81 417 Pfam PF00390 Malic enzyme, N-terminal domain 47 178 2.4E-27 T 09-03-2017 IPR012301 Malic enzyme, N-terminal domain GO:0004471|GO:0055114 TK78_RS10055 ac27d89bfa6d9d2652e395dc462d3c81 417 Gene3D G3DSA:3.40.50.10380 43 187 8.9E-54 T 09-03-2017 IPR012301 Malic enzyme, N-terminal domain GO:0004471|GO:0055114 TK78_RS10055 ac27d89bfa6d9d2652e395dc462d3c81 417 SUPERFAMILY SSF53223 40 188 6.12E-56 T 09-03-2017 TK78_RS10055 ac27d89bfa6d9d2652e395dc462d3c81 417 SMART SM00919 190 410 4.8E-105 T 09-03-2017 IPR012302 Malic enzyme, NAD-binding GO:0004471|GO:0051287|GO:0055114 TK78_RS16800 31075311e3a673160ea1dd2751573d01 303 SMART SM00942 231 293 8.8E-7 T 09-03-2017 IPR014820 Primase, C-terminal 1 TK78_RS16800 31075311e3a673160ea1dd2751573d01 303 SMART SM00943 16 200 7.9E-40 T 09-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal TK78_RS16800 31075311e3a673160ea1dd2751573d01 303 SUPERFAMILY SSF56747 13 209 5.89E-31 T 09-03-2017 TK78_RS16800 31075311e3a673160ea1dd2751573d01 303 Pfam PF09250 Bifunctional DNA primase/polymerase, N-terminal 16 197 9.0E-43 T 09-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal TK78_RS27445 ad7bbd54c5cc71f81205ad7d471a6409 381 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 231 374 8.1E-18 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS27445 ad7bbd54c5cc71f81205ad7d471a6409 381 SUPERFAMILY SSF47203 231 376 1.43E-19 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS27445 ad7bbd54c5cc71f81205ad7d471a6409 381 Gene3D G3DSA:1.20.140.10 222 379 1.7E-28 T 09-03-2017 TK78_RS27445 ad7bbd54c5cc71f81205ad7d471a6409 381 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 11 120 2.2E-18 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS27445 ad7bbd54c5cc71f81205ad7d471a6409 381 Gene3D G3DSA:2.40.110.10 123 221 1.1E-24 T 09-03-2017 TK78_RS27445 ad7bbd54c5cc71f81205ad7d471a6409 381 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 125 216 2.0E-14 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS27445 ad7bbd54c5cc71f81205ad7d471a6409 381 SUPERFAMILY SSF56645 2 239 1.44E-58 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS27445 ad7bbd54c5cc71f81205ad7d471a6409 381 Gene3D G3DSA:1.10.540.10 1 122 4.7E-23 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS00770 2938c18baf21dffa58fd47ebc87d384b 313 SUPERFAMILY SSF161098 95 297 1.34E-16 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS00770 2938c18baf21dffa58fd47ebc87d384b 313 Gene3D G3DSA:1.10.3720.10 92 308 1.1E-21 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS00770 2938c18baf21dffa58fd47ebc87d384b 313 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 114 311 3.8E-32 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS32135 4db1e096d311d209fe0b4445789634b5 590 Pfam PF08021 Siderophore-interacting FAD-binding domain 19 141 1.1E-27 T 09-03-2017 IPR013113 FAD-binding 9, siderophore-interacting TK78_RS32135 4db1e096d311d209fe0b4445789634b5 590 SUPERFAMILY SSF46785 292 364 2.89E-6 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32135 4db1e096d311d209fe0b4445789634b5 590 Gene3D G3DSA:1.10.10.10 295 366 6.0E-8 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32135 4db1e096d311d209fe0b4445789634b5 590 Gene3D G3DSA:3.40.50.80 144 265 8.0E-36 T 09-03-2017 TK78_RS32135 4db1e096d311d209fe0b4445789634b5 590 SUPERFAMILY SSF63380 87 143 1.93E-7 T 09-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 TK78_RS32135 4db1e096d311d209fe0b4445789634b5 590 SUPERFAMILY SSF63380 8 56 1.93E-7 T 09-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 TK78_RS32135 4db1e096d311d209fe0b4445789634b5 590 Gene3D G3DSA:2.40.30.10 10 140 2.6E-30 T 09-03-2017 TK78_RS32135 4db1e096d311d209fe0b4445789634b5 590 Pfam PF04954 Siderophore-interacting protein 149 263 2.1E-29 T 09-03-2017 IPR007037 Siderophore-interacting protein TK78_RS02355 5a7a814bf2beb725afb4ed6fe443dfac 404 SUPERFAMILY SSF81606 193 393 8.89E-5 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS02355 5a7a814bf2beb725afb4ed6fe443dfac 404 SMART SM00331 173 397 6.0E-7 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS02355 5a7a814bf2beb725afb4ed6fe443dfac 404 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 205 396 3.1E-34 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS02355 5a7a814bf2beb725afb4ed6fe443dfac 404 SUPERFAMILY SSF52172 19 169 5.55E-23 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS02355 5a7a814bf2beb725afb4ed6fe443dfac 404 SMART SM00448 19 133 4.3E-15 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS02355 5a7a814bf2beb725afb4ed6fe443dfac 404 Gene3D G3DSA:3.40.50.2300 19 146 4.5E-24 T 09-03-2017 TK78_RS02355 5a7a814bf2beb725afb4ed6fe443dfac 404 Pfam PF00072 Response regulator receiver domain 21 123 7.7E-12 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS17525 8b744092583eaec5b7de735878c0f9e2 499 Gene3D G3DSA:3.60.40.10 2 237 1.6E-73 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS17525 8b744092583eaec5b7de735878c0f9e2 499 SMART SM00332 2 235 1.4E-26 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS17525 8b744092583eaec5b7de735878c0f9e2 499 SUPERFAMILY SSF81606 4 236 3.4E-66 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS17525 8b744092583eaec5b7de735878c0f9e2 499 Pfam PF00481 Protein phosphatase 2C 22 230 6.0E-11 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS17525 8b744092583eaec5b7de735878c0f9e2 499 SMART SM00331 11 237 1.4E-36 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS23070 e25714beeeabe62ef0589a0fbcf498a0 285 ProSitePatterns PS00211 ABC transporters family signature. 181 195 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS23070 e25714beeeabe62ef0589a0fbcf498a0 285 Gene3D G3DSA:3.40.50.300 33 282 5.1E-82 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23070 e25714beeeabe62ef0589a0fbcf498a0 285 PIRSF PIRSF039085 31 285 3.6E-99 T 09-03-2017 IPR030679 ABC-type amino acid transport system, ATPase component, HisP-type GO:0003333|GO:0015424 TK78_RS23070 e25714beeeabe62ef0589a0fbcf498a0 285 Pfam PF00005 ABC transporter 50 209 1.1E-35 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS23070 e25714beeeabe62ef0589a0fbcf498a0 285 SUPERFAMILY SSF52540 34 280 4.69E-75 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23070 e25714beeeabe62ef0589a0fbcf498a0 285 TIGRFAM TIGR03005 ectoine_ehuA: ectoine/hydroxyectoine ABC transporter, ATP-binding protein EhuA 35 284 9.0E-109 T 09-03-2017 IPR014343 Ectoine/hydroxyectoine ABC transporter, ATP-binding protein TK78_RS23070 e25714beeeabe62ef0589a0fbcf498a0 285 SMART SM00382 59 258 1.9E-21 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS20300 c7656afe7ceb372144f676ed7d3c8084 462 Pfam PF00375 Sodium:dicarboxylate symporter family 31 419 5.0E-111 T 09-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 TK78_RS20300 c7656afe7ceb372144f676ed7d3c8084 462 SUPERFAMILY SSF118215 31 419 5.49E-101 T 09-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 TK78_RS20300 c7656afe7ceb372144f676ed7d3c8084 462 PRINTS PR00173 Glutamate-aspartate symporter signature 313 339 7.2E-28 T 09-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 TK78_RS20300 c7656afe7ceb372144f676ed7d3c8084 462 PRINTS PR00173 Glutamate-aspartate symporter signature 29 49 7.2E-28 T 09-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 TK78_RS20300 c7656afe7ceb372144f676ed7d3c8084 462 PRINTS PR00173 Glutamate-aspartate symporter signature 374 394 7.2E-28 T 09-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 TK78_RS20300 c7656afe7ceb372144f676ed7d3c8084 462 PRINTS PR00173 Glutamate-aspartate symporter signature 101 126 7.2E-28 T 09-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 TK78_RS20300 c7656afe7ceb372144f676ed7d3c8084 462 PRINTS PR00173 Glutamate-aspartate symporter signature 348 367 7.2E-28 T 09-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 TK78_RS20300 c7656afe7ceb372144f676ed7d3c8084 462 PRINTS PR00173 Glutamate-aspartate symporter signature 71 91 7.2E-28 T 09-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 TK78_RS20300 c7656afe7ceb372144f676ed7d3c8084 462 PRINTS PR00173 Glutamate-aspartate symporter signature 211 230 7.2E-28 T 09-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 TK78_RS20300 c7656afe7ceb372144f676ed7d3c8084 462 Gene3D G3DSA:1.10.3860.10 27 423 1.5E-109 T 09-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 TK78_RS11850 d7343596706ec5335579c98bc8f853dd 409 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 27 312 1.3E-80 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS11850 d7343596706ec5335579c98bc8f853dd 409 SUPERFAMILY SSF53686 15 321 9.43E-94 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS11850 d7343596706ec5335579c98bc8f853dd 409 ProSitePatterns PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 52 65 - T 09-03-2017 IPR000634 Serine/threonine dehydratase, pyridoxal-phosphate-binding site GO:0006520|GO:0030170 TK78_RS11850 d7343596706ec5335579c98bc8f853dd 409 TIGRFAM TIGR01127 ilvA_1Cterm: threonine ammonia-lyase 31 407 7.2E-129 T 09-03-2017 IPR005789 Threonine dehydratase, catabolic GO:0004794|GO:0006567 KEGG: 00260+4.3.1.19|KEGG: 00290+4.3.1.19 TK78_RS11850 d7343596706ec5335579c98bc8f853dd 409 Gene3D G3DSA:3.40.50.1100 80 329 1.2E-77 T 09-03-2017 TK78_RS07885 2f228f8a09f91a0ff80c8c92b44989a7 413 PIRSF PIRSF000505 2 411 2.5E-126 T 09-03-2017 IPR006264 3-phosphoshikimate 1-carboxyvinyltransferase GO:0003866 KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163 TK78_RS07885 2f228f8a09f91a0ff80c8c92b44989a7 413 ProSitePatterns PS00885 EPSP synthase signature 2. 322 340 - T 09-03-2017 IPR023193 3-phosphoshikimate 1-carboxyvinyltransferase, conserved site KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163 TK78_RS07885 2f228f8a09f91a0ff80c8c92b44989a7 413 Hamap MF_00210 3-phosphoshikimate 1-carboxyvinyltransferase [aroA]. 1 409 28.551 T 09-03-2017 IPR006264 3-phosphoshikimate 1-carboxyvinyltransferase GO:0003866 KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163 TK78_RS07885 2f228f8a09f91a0ff80c8c92b44989a7 413 SUPERFAMILY SSF55205 4 405 7.74E-105 T 09-03-2017 IPR013792 RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta GO:0003824 TK78_RS07885 2f228f8a09f91a0ff80c8c92b44989a7 413 Pfam PF00275 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) 3 401 4.4E-106 T 09-03-2017 IPR001986 Enolpyruvate transferase domain GO:0016765 TK78_RS07885 2f228f8a09f91a0ff80c8c92b44989a7 413 Gene3D G3DSA:3.65.10.10 222 406 2.7E-63 T 09-03-2017 IPR001986 Enolpyruvate transferase domain GO:0016765 TK78_RS07885 2f228f8a09f91a0ff80c8c92b44989a7 413 TIGRFAM TIGR01356 aroA: 3-phosphoshikimate 1-carboxyvinyltransferase 4 406 3.4E-121 T 09-03-2017 IPR006264 3-phosphoshikimate 1-carboxyvinyltransferase GO:0003866 KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163 TK78_RS07885 2f228f8a09f91a0ff80c8c92b44989a7 413 Gene3D G3DSA:3.65.10.10 10 221 1.1E-56 T 09-03-2017 IPR001986 Enolpyruvate transferase domain GO:0016765 TK78_RS19550 9e4e0e482513af97a4f6f131e3ddd4d6 213 Pfam PF03551 Transcriptional regulator PadR-like family 9 85 2.5E-10 T 09-03-2017 IPR005149 Transcription regulator PadR, N-terminal TK78_RS19550 9e4e0e482513af97a4f6f131e3ddd4d6 213 SUPERFAMILY SSF46785 4 178 6.21E-24 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS19550 9e4e0e482513af97a4f6f131e3ddd4d6 213 Gene3D G3DSA:1.10.10.10 4 97 3.2E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS29470 26afb1b91974cd9f296c41a7fdf95cc2 456 Gene3D G3DSA:1.10.579.10 272 450 2.7E-72 T 09-03-2017 TK78_RS29470 26afb1b91974cd9f296c41a7fdf95cc2 456 Pfam PF00875 DNA photolyase 5 161 2.0E-38 T 09-03-2017 IPR006050 DNA photolyase, N-terminal Reactome: R-HSA-1368108|Reactome: R-HSA-400253 TK78_RS29470 26afb1b91974cd9f296c41a7fdf95cc2 456 Pfam PF03441 FAD binding domain of DNA photolyase 264 450 1.1E-73 T 09-03-2017 IPR005101 Cryptochrome/DNA photolyase, FAD-binding domain Reactome: R-HSA-1368108|Reactome: R-HSA-400253 TK78_RS29470 26afb1b91974cd9f296c41a7fdf95cc2 456 SUPERFAMILY SSF48173 191 451 3.79E-94 T 09-03-2017 IPR005101 Cryptochrome/DNA photolyase, FAD-binding domain Reactome: R-HSA-1368108|Reactome: R-HSA-400253 TK78_RS29470 26afb1b91974cd9f296c41a7fdf95cc2 456 Gene3D G3DSA:3.40.50.620 1 149 1.8E-38 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS29470 26afb1b91974cd9f296c41a7fdf95cc2 456 SUPERFAMILY SSF52425 4 186 5.23E-38 T 09-03-2017 IPR006050 DNA photolyase, N-terminal Reactome: R-HSA-1368108|Reactome: R-HSA-400253 TK78_RS29470 26afb1b91974cd9f296c41a7fdf95cc2 456 Gene3D G3DSA:1.25.40.80 197 271 1.0E-27 T 09-03-2017 TK78_RS29470 26afb1b91974cd9f296c41a7fdf95cc2 456 Gene3D G3DSA:1.25.40.80 150 164 1.0E-27 T 09-03-2017 TK78_RS29470 26afb1b91974cd9f296c41a7fdf95cc2 456 ProSitePatterns PS00691 DNA photolyases class 1 signature 2. 331 350 - T 09-03-2017 IPR018394 Cryptochrome/DNA photolyase class 1, conserved site, C-terminal TK78_RS29470 26afb1b91974cd9f296c41a7fdf95cc2 456 PRINTS PR00147 DNA photolyase signature 143 159 5.3E-26 T 09-03-2017 IPR002081 Cryptochrome/DNA photolyase class 1 TK78_RS29470 26afb1b91974cd9f296c41a7fdf95cc2 456 PRINTS PR00147 DNA photolyase signature 331 349 5.3E-26 T 09-03-2017 IPR002081 Cryptochrome/DNA photolyase class 1 TK78_RS29470 26afb1b91974cd9f296c41a7fdf95cc2 456 PRINTS PR00147 DNA photolyase signature 370 384 5.3E-26 T 09-03-2017 IPR002081 Cryptochrome/DNA photolyase class 1 TK78_RS29470 26afb1b91974cd9f296c41a7fdf95cc2 456 PRINTS PR00147 DNA photolyase signature 311 327 5.3E-26 T 09-03-2017 IPR002081 Cryptochrome/DNA photolyase class 1 TK78_RS29470 26afb1b91974cd9f296c41a7fdf95cc2 456 ProSitePatterns PS00394 DNA photolyases class 1 signature 1. 311 323 - T 09-03-2017 IPR018394 Cryptochrome/DNA photolyase class 1, conserved site, C-terminal TK78_RS14330 38ad1fab7c1b9fef27254ac2a8df264b 328 TIGRFAM TIGR01188 drrA: daunorubicin resistance ABC transporter, ATP-binding protein 15 313 1.8E-103 T 09-03-2017 IPR005894 Daunorubicin resistance ABC transporter ATP-binding subunit DrrA GO:0005524|GO:0043215|GO:1900753 TK78_RS14330 38ad1fab7c1b9fef27254ac2a8df264b 328 Pfam PF00005 ABC transporter 23 166 6.6E-25 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS14330 38ad1fab7c1b9fef27254ac2a8df264b 328 SMART SM00382 32 215 4.7E-10 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS14330 38ad1fab7c1b9fef27254ac2a8df264b 328 ProSitePatterns PS00211 ABC transporters family signature. 139 153 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS14330 38ad1fab7c1b9fef27254ac2a8df264b 328 SUPERFAMILY SSF52540 9 228 1.71E-56 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS14330 38ad1fab7c1b9fef27254ac2a8df264b 328 Pfam PF13732 Domain of unknown function (DUF4162) 221 311 1.0E-7 T 09-03-2017 IPR025302 Domain of unknown function DUF4162 TK78_RS14330 38ad1fab7c1b9fef27254ac2a8df264b 328 Gene3D G3DSA:3.40.50.300 6 230 1.3E-63 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS19085 a1be944f9757513d4e32c7950b6076ba 170 TIGRFAM TIGR00151 ispF: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 17 167 8.8E-43 T 09-03-2017 IPR003526 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase GO:0008685|GO:0016114 KEGG: 00900+4.6.1.12|MetaCyc: PWY-7560 TK78_RS19085 a1be944f9757513d4e32c7950b6076ba 170 Hamap MF_00107 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [ispF]. 15 168 30.268 T 09-03-2017 IPR003526 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase GO:0008685|GO:0016114 KEGG: 00900+4.6.1.12|MetaCyc: PWY-7560 TK78_RS19085 a1be944f9757513d4e32c7950b6076ba 170 Pfam PF02542 YgbB family 17 166 2.6E-45 T 09-03-2017 IPR003526 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase GO:0008685|GO:0016114 KEGG: 00900+4.6.1.12|MetaCyc: PWY-7560 TK78_RS19085 a1be944f9757513d4e32c7950b6076ba 170 SUPERFAMILY SSF69765 15 168 5.89E-48 T 09-03-2017 IPR003526 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase GO:0008685|GO:0016114 KEGG: 00900+4.6.1.12|MetaCyc: PWY-7560 TK78_RS19085 a1be944f9757513d4e32c7950b6076ba 170 ProSitePatterns PS01350 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase signature. 50 65 - T 09-03-2017 IPR020555 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, conserved site GO:0008685 KEGG: 00900+4.6.1.12|MetaCyc: PWY-7560 TK78_RS19085 a1be944f9757513d4e32c7950b6076ba 170 Gene3D G3DSA:3.30.1330.50 15 168 2.7E-53 T 09-03-2017 IPR003526 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase GO:0008685|GO:0016114 KEGG: 00900+4.6.1.12|MetaCyc: PWY-7560 TK78_RS32940 3f37f5078cd35849a93d00c878079a2c 329 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 127 307 4.5E-9 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS32940 3f37f5078cd35849a93d00c878079a2c 329 SUPERFAMILY SSF161098 79 304 1.13E-44 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS32940 3f37f5078cd35849a93d00c878079a2c 329 Gene3D G3DSA:1.10.3720.10 23 306 1.1E-46 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS21080 f11f990c02386c30dbe885ac36b66fcf 148 SUPERFAMILY SSF55729 27 137 3.31E-19 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS21080 f11f990c02386c30dbe885ac36b66fcf 148 Pfam PF00583 Acetyltransferase (GNAT) family 63 133 7.7E-11 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS21080 f11f990c02386c30dbe885ac36b66fcf 148 Gene3D G3DSA:3.40.630.30 23 140 6.0E-25 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS23555 32ca08aa4a2e0f58ea3e0994a7d1a76a 265 SUPERFAMILY SSF47413 3 59 3.38E-13 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS23555 32ca08aa4a2e0f58ea3e0994a7d1a76a 265 Pfam PF13560 Helix-turn-helix domain 7 61 2.1E-13 T 09-03-2017 TK78_RS23555 32ca08aa4a2e0f58ea3e0994a7d1a76a 265 Gene3D G3DSA:1.10.260.40 4 59 7.9E-15 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS23555 32ca08aa4a2e0f58ea3e0994a7d1a76a 265 SMART SM00530 8 63 3.1E-13 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS01335 4ad10bf69bf8a96b59838fdf1452313a 157 Gene3D G3DSA:3.10.180.10 8 124 6.4E-28 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS01335 4ad10bf69bf8a96b59838fdf1452313a 157 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 7 122 1.1E-14 T 09-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain TK78_RS01335 4ad10bf69bf8a96b59838fdf1452313a 157 SUPERFAMILY SSF54593 6 130 5.24E-28 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS04955 b47517f08c34c41fc3328b2321e3a33f 209 TIGRFAM TIGR03083 TIGR03083: uncharacterized Actinobacterial protein TIGR03083 20 200 2.0E-23 T 09-03-2017 IPR017517 Conserved hypothetical protein CHP03083, actinobacterial-type TK78_RS04955 b47517f08c34c41fc3328b2321e3a33f 209 SUPERFAMILY SSF109854 14 150 5.49E-20 T 09-03-2017 TK78_RS04955 b47517f08c34c41fc3328b2321e3a33f 209 TIGRFAM TIGR03086 TIGR03086: TIGR03086 family protein 21 200 2.0E-50 T 09-03-2017 IPR017520 Conserved hypothetical protein CHP03086 TK78_RS04955 b47517f08c34c41fc3328b2321e3a33f 209 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 20 144 7.9E-17 T 09-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 TK78_RS33170 3b9e3f7e70ce5a7ec7ab856441dee9e3 207 SUPERFAMILY SSF48498 83 200 5.93E-13 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS33170 3b9e3f7e70ce5a7ec7ab856441dee9e3 207 Pfam PF00440 Bacterial regulatory proteins, tetR family 16 58 3.1E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS33170 3b9e3f7e70ce5a7ec7ab856441dee9e3 207 SUPERFAMILY SSF46689 5 77 1.54E-15 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS33170 3b9e3f7e70ce5a7ec7ab856441dee9e3 207 Pfam PF13977 Bacterial transcriptional repressor 85 197 5.9E-14 T 09-03-2017 TK78_RS33170 3b9e3f7e70ce5a7ec7ab856441dee9e3 207 Gene3D G3DSA:1.10.357.10 4 202 3.7E-43 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS26230 176433b96b984a007a2400808221ce01 535 Pfam PF07690 Major Facilitator Superfamily 29 425 1.8E-57 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS26230 176433b96b984a007a2400808221ce01 535 Gene3D G3DSA:1.20.1250.20 279 436 1.9E-25 T 09-03-2017 TK78_RS26230 176433b96b984a007a2400808221ce01 535 Gene3D G3DSA:1.20.1250.20 489 519 1.9E-25 T 09-03-2017 TK78_RS26230 176433b96b984a007a2400808221ce01 535 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 26 435 2.6E-79 T 09-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 TK78_RS26230 176433b96b984a007a2400808221ce01 535 SUPERFAMILY SSF103473 15 215 3.92E-73 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS26230 176433b96b984a007a2400808221ce01 535 SUPERFAMILY SSF103473 487 519 3.92E-73 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS26230 176433b96b984a007a2400808221ce01 535 SUPERFAMILY SSF103473 264 435 3.92E-73 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS26230 176433b96b984a007a2400808221ce01 535 Gene3D G3DSA:1.20.1250.20 19 209 1.4E-29 T 09-03-2017 TK78_RS26230 176433b96b984a007a2400808221ce01 535 PRINTS PR01036 Tetracycline resistance protein TetB signature 178 202 1.2E-8 T 09-03-2017 TK78_RS26230 176433b96b984a007a2400808221ce01 535 PRINTS PR01036 Tetracycline resistance protein TetB signature 123 143 1.2E-8 T 09-03-2017 TK78_RS26230 176433b96b984a007a2400808221ce01 535 PRINTS PR01036 Tetracycline resistance protein TetB signature 153 177 1.2E-8 T 09-03-2017 TK78_RS26230 176433b96b984a007a2400808221ce01 535 PRINTS PR01036 Tetracycline resistance protein TetB signature 28 52 1.2E-8 T 09-03-2017 TK78_RS26230 176433b96b984a007a2400808221ce01 535 PRINTS PR01036 Tetracycline resistance protein TetB signature 416 435 1.2E-8 T 09-03-2017 TK78_RS18000 cca69faf9c8e88bb8c9ad02d3de6a247 208 Gene3D G3DSA:3.40.50.10230 2 204 7.9E-84 T 09-03-2017 IPR003722 Cobalamin (vitamin B12) biosynthesis CobH/CbiC, precorrin-8X methylmutase GO:0009236|GO:0016993 TK78_RS18000 cca69faf9c8e88bb8c9ad02d3de6a247 208 SUPERFAMILY SSF63965 2 205 3.92E-76 T 09-03-2017 IPR003722 Cobalamin (vitamin B12) biosynthesis CobH/CbiC, precorrin-8X methylmutase GO:0009236|GO:0016993 TK78_RS18000 cca69faf9c8e88bb8c9ad02d3de6a247 208 Pfam PF02570 Precorrin-8X methylmutase 11 205 9.1E-76 T 09-03-2017 IPR003722 Cobalamin (vitamin B12) biosynthesis CobH/CbiC, precorrin-8X methylmutase GO:0009236|GO:0016993 TK78_RS31765 2077f80dec15dd988fe33f7c44a6be20 619 Gene3D G3DSA:1.20.1560.10 37 326 4.7E-33 T 09-03-2017 TK78_RS31765 2077f80dec15dd988fe33f7c44a6be20 619 ProSitePatterns PS00211 ABC transporters family signature. 485 499 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS31765 2077f80dec15dd988fe33f7c44a6be20 619 SUPERFAMILY SSF90123 20 327 5.36E-43 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS31765 2077f80dec15dd988fe33f7c44a6be20 619 SUPERFAMILY SSF52540 398 581 4.89E-34 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31765 2077f80dec15dd988fe33f7c44a6be20 619 Pfam PF00664 ABC transporter transmembrane region 49 302 5.9E-22 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS31765 2077f80dec15dd988fe33f7c44a6be20 619 Gene3D G3DSA:3.40.50.300 403 590 7.3E-35 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31765 2077f80dec15dd988fe33f7c44a6be20 619 Pfam PF00005 ABC transporter 409 513 1.6E-10 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS14525 0c7549d71df027544d7a8d4c735b160b 268 Gene3D G3DSA:3.40.50.720 14 265 7.4E-55 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS14525 0c7549d71df027544d7a8d4c735b160b 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 179 198 7.6E-20 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS14525 0c7549d71df027544d7a8d4c735b160b 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 230 250 7.6E-20 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS14525 0c7549d71df027544d7a8d4c735b160b 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 19 36 7.6E-20 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS14525 0c7549d71df027544d7a8d4c735b160b 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 200 217 7.6E-20 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS14525 0c7549d71df027544d7a8d4c735b160b 268 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 166 194 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS14525 0c7549d71df027544d7a8d4c735b160b 268 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 29 266 7.7E-35 T 09-03-2017 TK78_RS14525 0c7549d71df027544d7a8d4c735b160b 268 SUPERFAMILY SSF51735 19 265 4.21E-52 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS02880 a5b006c0244af9757dfe22811fee9117 167 Pfam PF13302 Acetyltransferase (GNAT) domain 15 147 5.2E-20 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS02880 a5b006c0244af9757dfe22811fee9117 167 SUPERFAMILY SSF55729 7 150 4.48E-30 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS02880 a5b006c0244af9757dfe22811fee9117 167 Gene3D G3DSA:3.40.630.30 6 153 1.7E-35 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS12050 0d0c477de5975b2f12c54eaf0c58785f 315 Gene3D G3DSA:3.20.20.70 50 307 5.8E-92 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS12050 0d0c477de5975b2f12c54eaf0c58785f 315 Pfam PF01791 DeoC/LacD family aldolase 52 294 4.8E-27 T 09-03-2017 IPR002915 DeoC/FbaB/ lacD aldolase GO:0016829 Reactome: R-HSA-71336 TK78_RS12050 0d0c477de5975b2f12c54eaf0c58785f 315 SMART SM01133 56 296 9.3E-74 T 09-03-2017 IPR002915 DeoC/FbaB/ lacD aldolase GO:0016829 Reactome: R-HSA-71336 TK78_RS12050 0d0c477de5975b2f12c54eaf0c58785f 315 TIGRFAM TIGR00126 deoC: deoxyribose-phosphate aldolase 59 277 1.2E-52 T 09-03-2017 IPR011343 Deoxyribose-phosphate aldolase GO:0004139|GO:0005737|GO:0009264 KEGG: 00030+4.1.2.4|MetaCyc: PWY-7180|Reactome: R-HSA-71336 TK78_RS12050 0d0c477de5975b2f12c54eaf0c58785f 315 SUPERFAMILY SSF51569 57 295 1.36E-72 T 09-03-2017 TK78_RS12050 0d0c477de5975b2f12c54eaf0c58785f 315 PIRSF PIRSF001357 50 305 6.2E-83 T 09-03-2017 IPR011343 Deoxyribose-phosphate aldolase GO:0004139|GO:0005737|GO:0009264 KEGG: 00030+4.1.2.4|MetaCyc: PWY-7180|Reactome: R-HSA-71336 TK78_RS04595 4080a25121eb4cf69999840006418230 269 ProSitePatterns PS00166 Enoyl-CoA hydratase/isomerase signature. 110 130 - T 09-03-2017 IPR018376 Enoyl-CoA hydratase/isomerase, conserved site GO:0003824|GO:0008152 TK78_RS04595 4080a25121eb4cf69999840006418230 269 SUPERFAMILY SSF52096 13 268 2.49E-90 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS04595 4080a25121eb4cf69999840006418230 269 Pfam PF00378 Enoyl-CoA hydratase/isomerase 26 268 8.4E-77 T 09-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 TK78_RS04595 4080a25121eb4cf69999840006418230 269 Gene3D G3DSA:3.90.226.10 13 207 1.4E-76 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS04595 4080a25121eb4cf69999840006418230 269 Gene3D G3DSA:1.10.12.10 216 269 4.2E-23 T 09-03-2017 IPR014748 Crontonase, C-terminal TK78_RS18235 dc5aa38a15645d1014666a8481141765 83 Gene3D G3DSA:3.30.1280.10 3 81 1.2E-33 T 09-03-2017 IPR003850 Phosphoribosylformylglycinamidine synthase subunit PurS KEGG: 00230+6.3.5.3|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277 TK78_RS18235 dc5aa38a15645d1014666a8481141765 83 SUPERFAMILY SSF82697 3 81 7.67E-26 T 09-03-2017 TK78_RS18235 dc5aa38a15645d1014666a8481141765 83 TIGRFAM TIGR00302 TIGR00302: phosphoribosylformylglycinamidine synthase, purS protein 4 81 4.1E-22 T 09-03-2017 IPR003850 Phosphoribosylformylglycinamidine synthase subunit PurS KEGG: 00230+6.3.5.3|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277 TK78_RS18235 dc5aa38a15645d1014666a8481141765 83 Hamap MF_01926 Phosphoribosylformylglycinamidine synthase subunit PurS [purS]. 2 79 21.983 T 09-03-2017 IPR003850 Phosphoribosylformylglycinamidine synthase subunit PurS KEGG: 00230+6.3.5.3|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277 TK78_RS18235 dc5aa38a15645d1014666a8481141765 83 ProDom PD010362 PHOSPHORIBOSYLFORMYLGLYCINAMIDINE PURS SYNTHETASE SYNTHASE COMPONENT SYNTHASE LIGASE FGAM UPF0062 I 10 80 3.0E-31 T 09-03-2017 IPR003850 Phosphoribosylformylglycinamidine synthase subunit PurS KEGG: 00230+6.3.5.3|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277 TK78_RS18235 dc5aa38a15645d1014666a8481141765 83 Pfam PF02700 Phosphoribosylformylglycinamidine (FGAM) synthase 4 78 1.4E-28 T 09-03-2017 IPR003850 Phosphoribosylformylglycinamidine synthase subunit PurS KEGG: 00230+6.3.5.3|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277 TK78_RS19605 0f1798a2f9768d1a8cd13fd91a1681eb 567 Pfam PF06738 Putative threonine/serine exporter 146 390 5.0E-62 T 09-03-2017 IPR010619 Putative threonine/serine exporter TK78_RS19605 0f1798a2f9768d1a8cd13fd91a1681eb 567 Pfam PF12821 Threonine/Serine exporter, ThrE 413 539 1.3E-14 T 09-03-2017 IPR024528 Threonine/Serine exporter, ThrE TK78_RS15710 db93c0551a8f606d3c443534fb96af50 114 Pfam PF02575 YbaB/EbfC DNA-binding family 15 103 3.1E-31 T 09-03-2017 IPR004401 Nucleoid-associated protein YbaB/EbfC family TK78_RS15710 db93c0551a8f606d3c443534fb96af50 114 TIGRFAM TIGR00103 DNA_YbaB_EbfC: DNA-binding protein, YbaB/EbfC family 6 96 5.8E-24 T 09-03-2017 IPR004401 Nucleoid-associated protein YbaB/EbfC family TK78_RS15710 db93c0551a8f606d3c443534fb96af50 114 Gene3D G3DSA:3.30.1310.10 5 109 2.9E-40 T 09-03-2017 IPR004401 Nucleoid-associated protein YbaB/EbfC family TK78_RS15710 db93c0551a8f606d3c443534fb96af50 114 SUPERFAMILY SSF82607 14 104 6.8E-27 T 09-03-2017 IPR004401 Nucleoid-associated protein YbaB/EbfC family TK78_RS15710 db93c0551a8f606d3c443534fb96af50 114 Hamap MF_00274 Nucleoid-associated protein YbaB [ybaB]. 8 102 21.57 T 09-03-2017 IPR004401 Nucleoid-associated protein YbaB/EbfC family TK78_RS15710 db93c0551a8f606d3c443534fb96af50 114 PIRSF PIRSF004555 6 114 3.5E-33 T 09-03-2017 IPR004401 Nucleoid-associated protein YbaB/EbfC family TK78_RS26060 e546d4c812cc218c42a912332628be3f 485 PRINTS PR01036 Tetracycline resistance protein TetB signature 375 395 2.1E-8 T 09-03-2017 TK78_RS26060 e546d4c812cc218c42a912332628be3f 485 PRINTS PR01036 Tetracycline resistance protein TetB signature 94 116 2.1E-8 T 09-03-2017 TK78_RS26060 e546d4c812cc218c42a912332628be3f 485 PRINTS PR01036 Tetracycline resistance protein TetB signature 221 239 2.1E-8 T 09-03-2017 TK78_RS26060 e546d4c812cc218c42a912332628be3f 485 PRINTS PR01036 Tetracycline resistance protein TetB signature 34 58 2.1E-8 T 09-03-2017 TK78_RS26060 e546d4c812cc218c42a912332628be3f 485 PRINTS PR01036 Tetracycline resistance protein TetB signature 156 180 2.1E-8 T 09-03-2017 TK78_RS26060 e546d4c812cc218c42a912332628be3f 485 Pfam PF07690 Major Facilitator Superfamily 36 428 1.6E-60 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS26060 e546d4c812cc218c42a912332628be3f 485 SUPERFAMILY SSF103473 266 477 1.31E-64 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS26060 e546d4c812cc218c42a912332628be3f 485 SUPERFAMILY SSF103473 13 218 1.31E-64 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS26060 e546d4c812cc218c42a912332628be3f 485 Gene3D G3DSA:1.20.1250.20 281 474 1.7E-20 T 09-03-2017 TK78_RS26060 e546d4c812cc218c42a912332628be3f 485 Gene3D G3DSA:1.20.1250.20 32 214 9.9E-28 T 09-03-2017 TK78_RS21440 4ae3f2e781e0fcd79e18e4ff3b04732c 304 Pfam PF13560 Helix-turn-helix domain 5 60 2.6E-8 T 09-03-2017 TK78_RS21440 4ae3f2e781e0fcd79e18e4ff3b04732c 304 SUPERFAMILY SSF47413 4 52 3.94E-6 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS21440 4ae3f2e781e0fcd79e18e4ff3b04732c 304 SMART SM00530 8 63 1.1E-4 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS21440 4ae3f2e781e0fcd79e18e4ff3b04732c 304 Gene3D G3DSA:1.10.260.40 5 53 1.5E-8 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS06900 adaf50f159e6bea28ea621aa2ad0df70 194 Pfam PF03061 Thioesterase superfamily 75 142 1.0E-8 T 09-03-2017 IPR006683 Thioesterase domain Reactome: R-HSA-75105 TK78_RS06900 adaf50f159e6bea28ea621aa2ad0df70 194 SUPERFAMILY SSF54637 21 159 6.43E-32 T 09-03-2017 IPR029069 HotDog domain TK78_RS06900 adaf50f159e6bea28ea621aa2ad0df70 194 Gene3D G3DSA:3.10.129.10 21 167 1.3E-43 T 09-03-2017 IPR029069 HotDog domain TK78_RS15330 0996957f80aa754b8bbef847579fedc5 171 TIGRFAM TIGR03816 tadE_like_DECH: helicase/secretion neighborhood TadE-like protein 20 123 3.0E-25 T 09-03-2017 IPR021202 Helicase/secretion neighbourhood TadE-like protein TK78_RS15330 0996957f80aa754b8bbef847579fedc5 171 Pfam PF13400 Putative Flp pilus-assembly TadE/G-like 22 68 5.7E-6 T 09-03-2017 IPR028087 Putative Flp pilus-assembly TadG-like, N-terminal TK78_RS34325 128ae09332637e33b99b20460b006005 679 PRINTS PR00364 Disease resistance protein signature 30 45 3.0E-5 T 09-03-2017 TK78_RS34325 128ae09332637e33b99b20460b006005 679 PRINTS PR00364 Disease resistance protein signature 99 113 3.0E-5 T 09-03-2017 TK78_RS34325 128ae09332637e33b99b20460b006005 679 PRINTS PR00364 Disease resistance protein signature 198 212 3.0E-5 T 09-03-2017 TK78_RS34325 128ae09332637e33b99b20460b006005 679 Gene3D G3DSA:1.25.40.10 478 604 5.9E-7 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS34325 128ae09332637e33b99b20460b006005 679 Gene3D G3DSA:3.40.50.300 13 138 1.8E-4 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS34325 128ae09332637e33b99b20460b006005 679 SUPERFAMILY SSF48452 395 528 6.17E-10 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS34325 128ae09332637e33b99b20460b006005 679 Gene3D G3DSA:1.25.40.10 399 460 3.4E-4 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS34325 128ae09332637e33b99b20460b006005 679 SUPERFAMILY SSF52540 4 234 3.63E-19 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06665 3f0ad7e8f0e26b0ed8a1e189e5d12efb 533 Gene3D G3DSA:3.40.190.10 205 302 1.3E-26 T 09-03-2017 TK78_RS06665 3f0ad7e8f0e26b0ed8a1e189e5d12efb 533 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 85 450 2.5E-66 T 09-03-2017 IPR000914 Solute-binding protein family 5 domain TK78_RS06665 3f0ad7e8f0e26b0ed8a1e189e5d12efb 533 Gene3D G3DSA:3.90.76.10 52 204 7.3E-31 T 09-03-2017 TK78_RS06665 3f0ad7e8f0e26b0ed8a1e189e5d12efb 533 Gene3D G3DSA:3.10.105.10 303 498 1.1E-31 T 09-03-2017 TK78_RS06665 3f0ad7e8f0e26b0ed8a1e189e5d12efb 533 SUPERFAMILY SSF53850 44 523 3.72E-102 T 09-03-2017 TK78_RS06665 3f0ad7e8f0e26b0ed8a1e189e5d12efb 533 PIRSF PIRSF002741 3 529 2.8E-72 T 09-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 TK78_RS31240 b00cceef97ffc2c48ef0dd74b2a968fd 163 Pfam PF13577 SnoaL-like domain 10 153 1.1E-19 T 09-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain TK78_RS31240 b00cceef97ffc2c48ef0dd74b2a968fd 163 Gene3D G3DSA:3.10.450.50 9 161 1.3E-41 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS31240 b00cceef97ffc2c48ef0dd74b2a968fd 163 SUPERFAMILY SSF54427 7 160 8.01E-23 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS18460 aaf354afbad7ac127461e1aea23c634a 699 SUPERFAMILY SSF56235 72 198 5.14E-12 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS18460 aaf354afbad7ac127461e1aea23c634a 699 Gene3D G3DSA:3.60.20.10 94 196 8.9E-10 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS18460 aaf354afbad7ac127461e1aea23c634a 699 Pfam PF00733 Asparagine synthase 268 665 2.1E-10 T 09-03-2017 IPR001962 Asparagine synthase GO:0004066|GO:0006529 TK78_RS18460 aaf354afbad7ac127461e1aea23c634a 699 SUPERFAMILY SSF52402 524 633 1.4E-7 T 09-03-2017 TK78_RS18460 aaf354afbad7ac127461e1aea23c634a 699 SUPERFAMILY SSF52402 265 393 1.4E-7 T 09-03-2017 TK78_RS18460 aaf354afbad7ac127461e1aea23c634a 699 SUPERFAMILY SSF52402 215 234 1.4E-7 T 09-03-2017 TK78_RS18460 aaf354afbad7ac127461e1aea23c634a 699 Gene3D G3DSA:3.40.50.620 520 665 3.8E-9 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS18460 aaf354afbad7ac127461e1aea23c634a 699 Gene3D G3DSA:3.40.50.620 212 399 3.8E-9 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS29415 a6ecdc219a6beba82757812af6c9dfb1 98 Hamap MF_00236 Sec-independent protein translocase protein TatA [tatA]. 2 79 19.29 T 09-03-2017 IPR006312 Sec-independent protein translocase protein TatA/E GO:0005886|GO:0008565|GO:0009306|GO:0015031|GO:0016021 TK78_RS29415 a6ecdc219a6beba82757812af6c9dfb1 98 Pfam PF02416 mttA/Hcf106 family 8 53 3.9E-15 T 09-03-2017 IPR003369 Sec-independent protein translocase protein TatA/B/E GO:0008565|GO:0015031 TK78_RS29415 a6ecdc219a6beba82757812af6c9dfb1 98 TIGRFAM TIGR01411 tatAE: twin arginine-targeting protein translocase, TatA/E family 5 49 6.1E-16 T 09-03-2017 IPR006312 Sec-independent protein translocase protein TatA/E GO:0005886|GO:0008565|GO:0009306|GO:0015031|GO:0016021 TK78_RS25980 7eb686d4d350759b25441465ea263fcb 347 Gene3D G3DSA:3.40.50.1980 191 345 5.8E-33 T 09-03-2017 TK78_RS25980 7eb686d4d350759b25441465ea263fcb 347 Gene3D G3DSA:3.40.50.1980 73 190 9.5E-35 T 09-03-2017 TK78_RS25980 7eb686d4d350759b25441465ea263fcb 347 Pfam PF01497 Periplasmic binding protein 95 319 1.1E-26 T 09-03-2017 IPR002491 ABC transporter periplasmic binding domain GO:0005488 TK78_RS25980 7eb686d4d350759b25441465ea263fcb 347 SUPERFAMILY SSF53807 75 341 5.49E-61 T 09-03-2017 TK78_RS26110 45a44b78621c41b6e022bb4ff0da4a7c 331 Gene3D G3DSA:3.40.50.150 71 183 9.4E-9 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS26110 45a44b78621c41b6e022bb4ff0da4a7c 331 SUPERFAMILY SSF53335 52 214 2.54E-11 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS26110 45a44b78621c41b6e022bb4ff0da4a7c 331 Pfam PF09243 Mitochondrial small ribosomal subunit Rsm22 53 326 2.6E-98 T 09-03-2017 IPR015324 Ribosomal protein Rsm22, bacterial-type GO:0006412|GO:0008168 TK78_RS20805 caf06a9b204804e625ae1f4dc2bef94f 366 Pfam PF08279 HTH domain 7 62 2.2E-16 T 09-03-2017 IPR013196 Helix-turn-helix, type 11 TK78_RS20805 caf06a9b204804e625ae1f4dc2bef94f 366 Pfam PF13280 WYL domain 142 334 1.8E-24 T 09-03-2017 IPR026881 WYL domain TK78_RS20805 caf06a9b204804e625ae1f4dc2bef94f 366 SUPERFAMILY SSF46785 6 64 2.59E-11 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS20805 caf06a9b204804e625ae1f4dc2bef94f 366 Gene3D G3DSA:1.10.10.10 3 65 1.1E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS20805 caf06a9b204804e625ae1f4dc2bef94f 366 ProSitePatterns PS00894 DeoR-type HTH domain signature. 7 41 - T 09-03-2017 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 TK78_RS09565 65e1ec7e7469289f19bb94baa18f029b 331 Pfam PF00005 ABC transporter 18 156 6.6E-24 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS09565 65e1ec7e7469289f19bb94baa18f029b 331 SUPERFAMILY SSF52540 2 226 1.28E-55 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09565 65e1ec7e7469289f19bb94baa18f029b 331 Gene3D G3DSA:3.40.50.300 1 226 4.2E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09565 65e1ec7e7469289f19bb94baa18f029b 331 SMART SM00382 26 204 2.8E-8 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS15100 1471adc38822f57e7b10e05760819ff2 235 Gene3D G3DSA:3.40.1180.10 2 235 2.1E-43 T 09-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TK78_RS15100 1471adc38822f57e7b10e05760819ff2 235 Pfam PF01255 Putative undecaprenyl diphosphate synthase 10 234 4.6E-30 T 09-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TK78_RS15100 1471adc38822f57e7b10e05760819ff2 235 SUPERFAMILY SSF64005 2 229 2.62E-36 T 09-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TK78_RS32550 a1a82d92b63b246f663cde92b04e4cee 444 Pfam PF01494 FAD binding domain 20 332 5.8E-14 T 09-03-2017 IPR002938 FAD-binding domain GO:0071949 TK78_RS32550 a1a82d92b63b246f663cde92b04e4cee 444 Gene3D G3DSA:3.30.9.10 187 347 4.6E-45 T 09-03-2017 TK78_RS32550 a1a82d92b63b246f663cde92b04e4cee 444 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 306 321 2.4E-11 T 09-03-2017 TK78_RS32550 a1a82d92b63b246f663cde92b04e4cee 444 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 171 186 2.4E-11 T 09-03-2017 TK78_RS32550 a1a82d92b63b246f663cde92b04e4cee 444 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 21 43 2.4E-11 T 09-03-2017 TK78_RS32550 a1a82d92b63b246f663cde92b04e4cee 444 SUPERFAMILY SSF51905 20 192 5.25E-46 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS32550 a1a82d92b63b246f663cde92b04e4cee 444 SUPERFAMILY SSF51905 302 413 5.25E-46 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS32550 a1a82d92b63b246f663cde92b04e4cee 444 TIGRFAM TIGR02032 GG-red-SF: geranylgeranyl reductase family 22 340 2.1E-72 T 09-03-2017 IPR011777 Geranylgeranyl reductase family GO:0016628|GO:0055114 TK78_RS32550 a1a82d92b63b246f663cde92b04e4cee 444 Gene3D G3DSA:3.50.50.60 16 186 1.9E-19 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS25835 289abee25ca03a7ddf09fa0baca2bc21 150 SUPERFAMILY SSF53597 40 119 2.94E-8 T 09-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 TK78_RS25835 289abee25ca03a7ddf09fa0baca2bc21 150 Gene3D G3DSA:3.40.430.10 38 78 7.7E-4 T 09-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 TK78_RS33425 5a61606fc4df04607706c7151b52e3d8 169 SUPERFAMILY SSF55811 24 158 2.17E-15 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS33425 5a61606fc4df04607706c7151b52e3d8 169 ProSitePatterns PS00893 Nudix box signature. 51 72 - T 09-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 TK78_RS33425 5a61606fc4df04607706c7151b52e3d8 169 Gene3D G3DSA:3.90.79.10 5 158 1.9E-25 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS33425 5a61606fc4df04607706c7151b52e3d8 169 Pfam PF00293 NUDIX domain 40 155 1.4E-12 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS34070 9beadbb5bc9817148ab7ea359b6c6509 606 Gene3D G3DSA:3.40.710.10 77 423 7.3E-78 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS34070 9beadbb5bc9817148ab7ea359b6c6509 606 SUPERFAMILY SSF56601 73 422 5.36E-78 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS34070 9beadbb5bc9817148ab7ea359b6c6509 606 Pfam PF00144 Beta-lactamase 84 426 2.7E-68 T 09-03-2017 IPR001466 Beta-lactamase-related TK78_RS34070 9beadbb5bc9817148ab7ea359b6c6509 606 Pfam PF05547 Immune inhibitor A peptidase M6 442 586 2.6E-8 T 09-03-2017 IPR008757 Peptidase M6-like, domain GO:0006508|GO:0008233 TK78_RS02565 374e02ab30fe4d3448f4f434e666b985 300 Gene3D G3DSA:1.10.530.10 220 300 1.0E-55 T 09-03-2017 TK78_RS02565 374e02ab30fe4d3448f4f434e666b985 300 Gene3D G3DSA:1.10.530.10 99 156 1.0E-55 T 09-03-2017 TK78_RS02565 374e02ab30fe4d3448f4f434e666b985 300 PIRSF PIRSF001060 3 300 2.1E-84 T 09-03-2017 IPR016283 Glycoside hydrolase, family 19 GO:0004568|GO:0005975 KEGG: 00520+3.2.1.14|MetaCyc: PWY-6902 TK78_RS02565 374e02ab30fe4d3448f4f434e666b985 300 Pfam PF00182 Chitinase class I 99 300 1.0E-43 T 09-03-2017 IPR000726 Glycoside hydrolase, family 19, catalytic GO:0004568|GO:0006032|GO:0016998 KEGG: 00520+3.2.1.14|MetaCyc: PWY-6902 TK78_RS02565 374e02ab30fe4d3448f4f434e666b985 300 Gene3D G3DSA:3.30.20.10 165 219 5.1E-24 T 09-03-2017 TK78_RS02565 374e02ab30fe4d3448f4f434e666b985 300 SUPERFAMILY SSF53955 97 300 1.12E-67 T 09-03-2017 IPR023346 Lysozyme-like domain TK78_RS02565 374e02ab30fe4d3448f4f434e666b985 300 Gene3D G3DSA:2.10.10.20 39 82 9.9E-5 T 09-03-2017 IPR003610 Carbohydrate-binding module family 5/12 GO:0004553|GO:0005576|GO:0005975|GO:0030246 TK78_RS02565 374e02ab30fe4d3448f4f434e666b985 300 SUPERFAMILY SSF51055 31 67 3.14E-5 T 09-03-2017 IPR003610 Carbohydrate-binding module family 5/12 GO:0004553|GO:0005576|GO:0005975|GO:0030246 TK78_RS27435 ccfbfe30e5b85c578ebaa099d4340c22 163 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 37 111 4.3E-5 T 09-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS27435 ccfbfe30e5b85c578ebaa099d4340c22 163 SUPERFAMILY SSF50475 20 146 7.27E-18 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS27435 ccfbfe30e5b85c578ebaa099d4340c22 163 Gene3D G3DSA:2.30.110.10 24 139 8.4E-17 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS24585 d01c12d4763d442a8b959f26ad50777d 370 Gene3D G3DSA:3.30.2010.10 68 154 7.7E-21 T 09-03-2017 TK78_RS24585 d01c12d4763d442a8b959f26ad50777d 370 Pfam PF01435 Peptidase family M48 75 268 1.4E-24 T 09-03-2017 IPR001915 Peptidase M48 GO:0004222|GO:0006508 TK78_RS11830 7af25b3bfc82ce4480aa67cae52bd28f 138 Pfam PF14155 Domain of unknown function (DUF4307) 22 130 4.1E-33 T 09-03-2017 IPR025443 Protein of unknown function DUF4307 TK78_RS11105 af0b7ae8fb8e3912bcd137ba6923b294 68 Pfam PF04149 Domain of unknown function (DUF397) 9 63 3.9E-21 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS26375 05fe4910eab583f883a27a3d08324896 558 Gene3D G3DSA:3.20.20.80 201 491 1.5E-109 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS26375 05fe4910eab583f883a27a3d08324896 558 Gene3D G3DSA:3.20.20.80 22 122 1.5E-109 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS26375 05fe4910eab583f883a27a3d08324896 558 Pfam PF11941 Domain of unknown function (DUF3459) 476 556 6.9E-7 T 09-03-2017 IPR022567 Glycosyl hydrolase, C-terminal (DUF3459) TK78_RS26375 05fe4910eab583f883a27a3d08324896 558 SMART SM00642 31 427 1.9E-126 T 09-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 TK78_RS26375 05fe4910eab583f883a27a3d08324896 558 SUPERFAMILY SSF51445 23 490 2.86E-127 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS26375 05fe4910eab583f883a27a3d08324896 558 Pfam PF00128 Alpha amylase, catalytic domain 46 405 6.1E-78 T 09-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 TK78_RS26375 05fe4910eab583f883a27a3d08324896 558 Gene3D G3DSA:3.90.400.10 123 200 2.9E-28 T 09-03-2017 TK78_RS29195 a2abaa88097701818a7a988be9b58dcc 266 Pfam PF03777 Small secreted domain (DUF320) 24 79 1.4E-25 T 09-03-2017 IPR005528 Domain of unknown function DUF320, Streptomyces species TK78_RS29195 a2abaa88097701818a7a988be9b58dcc 266 Pfam PF03777 Small secreted domain (DUF320) 133 185 1.5E-24 T 09-03-2017 IPR005528 Domain of unknown function DUF320, Streptomyces species TK78_RS27260 4dcf1eadf2d09cae6519a741d27cb159 198 ProSitePatterns PS00954 Imidazoleglycerol-phosphate dehydratase signature 1. 63 76 - T 09-03-2017 IPR020565 Imidazoleglycerol-phosphate dehydratase, conserved site GO:0000105|GO:0004424 KEGG: 00340+4.2.1.19 TK78_RS27260 4dcf1eadf2d09cae6519a741d27cb159 198 Gene3D G3DSA:3.30.230.40 92 198 1.4E-28 T 09-03-2017 TK78_RS27260 4dcf1eadf2d09cae6519a741d27cb159 198 SUPERFAMILY SSF54211 4 87 1.24E-32 T 09-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold TK78_RS27260 4dcf1eadf2d09cae6519a741d27cb159 198 SUPERFAMILY SSF54211 89 181 1.52E-30 T 09-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold TK78_RS27260 4dcf1eadf2d09cae6519a741d27cb159 198 ProSitePatterns PS00955 Imidazoleglycerol-phosphate dehydratase signature 2. 159 171 - T 09-03-2017 IPR020565 Imidazoleglycerol-phosphate dehydratase, conserved site GO:0000105|GO:0004424 KEGG: 00340+4.2.1.19 TK78_RS27260 4dcf1eadf2d09cae6519a741d27cb159 198 Hamap MF_00076 Imidazoleglycerol-phosphate dehydratase [hisB]. 4 198 41.204 T 09-03-2017 IPR000807 Imidazoleglycerol-phosphate dehydratase GO:0000105|GO:0004424 KEGG: 00340+4.2.1.19 TK78_RS27260 4dcf1eadf2d09cae6519a741d27cb159 198 Gene3D G3DSA:3.30.230.40 4 90 9.0E-37 T 09-03-2017 TK78_RS27260 4dcf1eadf2d09cae6519a741d27cb159 198 Pfam PF00475 Imidazoleglycerol-phosphate dehydratase 33 177 2.5E-62 T 09-03-2017 IPR000807 Imidazoleglycerol-phosphate dehydratase GO:0000105|GO:0004424 KEGG: 00340+4.2.1.19 TK78_RS09760 ac4f25a0fdb73b1f7920247c422d883b 305 TIGRFAM TIGR00191 thrB: homoserine kinase 11 281 3.4E-65 T 09-03-2017 IPR000870 Homoserine kinase GO:0004413|GO:0005524|GO:0006566 KEGG: 00260+2.7.1.39|MetaCyc: PWY-702 TK78_RS09760 ac4f25a0fdb73b1f7920247c422d883b 305 PIRSF PIRSF000676 7 300 1.5E-84 T 09-03-2017 IPR000870 Homoserine kinase GO:0004413|GO:0005524|GO:0006566 KEGG: 00260+2.7.1.39|MetaCyc: PWY-702 TK78_RS09760 ac4f25a0fdb73b1f7920247c422d883b 305 Pfam PF08544 GHMP kinases C terminal 212 280 4.9E-7 T 09-03-2017 IPR013750 GHMP kinase, C-terminal domain TK78_RS09760 ac4f25a0fdb73b1f7920247c422d883b 305 SUPERFAMILY SSF54211 11 159 7.59E-31 T 09-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold TK78_RS09760 ac4f25a0fdb73b1f7920247c422d883b 305 PRINTS PR00958 Homoserine kinase signature 18 33 1.7E-33 T 09-03-2017 TK78_RS09760 ac4f25a0fdb73b1f7920247c422d883b 305 PRINTS PR00958 Homoserine kinase signature 138 151 1.7E-33 T 09-03-2017 TK78_RS09760 ac4f25a0fdb73b1f7920247c422d883b 305 PRINTS PR00958 Homoserine kinase signature 101 116 1.7E-33 T 09-03-2017 TK78_RS09760 ac4f25a0fdb73b1f7920247c422d883b 305 PRINTS PR00958 Homoserine kinase signature 177 194 1.7E-33 T 09-03-2017 TK78_RS09760 ac4f25a0fdb73b1f7920247c422d883b 305 PRINTS PR00958 Homoserine kinase signature 254 269 1.7E-33 T 09-03-2017 TK78_RS09760 ac4f25a0fdb73b1f7920247c422d883b 305 ProSitePatterns PS00627 GHMP kinases putative ATP-binding domain. 94 105 - T 09-03-2017 IPR006203 GHMP kinase, ATP-binding, conserved site GO:0005524 TK78_RS09760 ac4f25a0fdb73b1f7920247c422d883b 305 Hamap MF_00384 Homoserine kinase [thrB]. 11 300 29.569 T 09-03-2017 IPR000870 Homoserine kinase GO:0004413|GO:0005524|GO:0006566 KEGG: 00260+2.7.1.39|MetaCyc: PWY-702 TK78_RS09760 ac4f25a0fdb73b1f7920247c422d883b 305 Gene3D G3DSA:3.30.70.890 172 292 4.4E-34 T 09-03-2017 IPR013750 GHMP kinase, C-terminal domain TK78_RS09760 ac4f25a0fdb73b1f7920247c422d883b 305 Gene3D G3DSA:3.30.230.10 10 160 6.7E-58 T 09-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TK78_RS09760 ac4f25a0fdb73b1f7920247c422d883b 305 SUPERFAMILY SSF55060 175 289 1.04E-27 T 09-03-2017 IPR013750 GHMP kinase, C-terminal domain TK78_RS09760 ac4f25a0fdb73b1f7920247c422d883b 305 Pfam PF00288 GHMP kinases N terminal domain 88 151 4.1E-12 T 09-03-2017 IPR006204 GHMP kinase N-terminal domain GO:0005524 TK78_RS27745 2f607e990e0124fef7134bbe20bfd4f3 244 SUPERFAMILY SSF46785 31 138 1.93E-24 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS27745 2f607e990e0124fef7134bbe20bfd4f3 244 Pfam PF01638 HxlR-like helix-turn-helix 44 130 9.1E-21 T 09-03-2017 IPR002577 Helix-turn-helix, HxlR type TK78_RS27745 2f607e990e0124fef7134bbe20bfd4f3 244 Gene3D G3DSA:1.10.10.10 29 133 1.5E-28 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS26335 bbe5de111531825f590ba846c491add3 173 SUPERFAMILY SSF50475 24 169 3.93E-27 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS26335 bbe5de111531825f590ba846c491add3 173 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 27 112 7.4E-15 T 09-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS26335 bbe5de111531825f590ba846c491add3 173 Gene3D G3DSA:2.30.110.10 23 172 3.9E-43 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS34380 97bc289a4f50955fabf807738937d315 203 Pfam PF01810 LysE type translocator 16 201 3.0E-40 T 09-03-2017 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 TK78_RS29795 d7ccb03c7fa500936aac51df0dece309 335 TIGRFAM TIGR03945 PLP_SbnA_fam: 2,3-diaminopropionate biosynthesis protein SbnA 10 308 1.6E-115 T 09-03-2017 IPR023927 2,3-diaminopropionate biosynthesis protein SbnA TK78_RS29795 d7ccb03c7fa500936aac51df0dece309 335 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 20 289 1.1E-49 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS29795 d7ccb03c7fa500936aac51df0dece309 335 SUPERFAMILY SSF53686 19 312 8.51E-70 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS29795 d7ccb03c7fa500936aac51df0dece309 335 Gene3D G3DSA:3.40.50.1100 35 136 6.0E-25 T 09-03-2017 TK78_RS29795 d7ccb03c7fa500936aac51df0dece309 335 Gene3D G3DSA:3.40.50.1100 137 306 6.9E-46 T 09-03-2017 TK78_RS12430 1dc066ca4639063cc1a8b372b3a00d4a 330 Gene3D G3DSA:1.10.240.10 208 301 2.7E-15 T 09-03-2017 TK78_RS12430 1dc066ca4639063cc1a8b372b3a00d4a 330 SUPERFAMILY SSF52374 1 325 3.2E-98 T 09-03-2017 TK78_RS12430 1dc066ca4639063cc1a8b372b3a00d4a 330 Hamap MF_00140_B Tryptophan--tRNA ligase [trpS]. 1 326 41.146 T 09-03-2017 IPR024109 Tryptophan-tRNA ligase, bacterial-type GO:0004830 KEGG: 00970+6.1.1.2|Reactome: R-HSA-379726 TK78_RS12430 1dc066ca4639063cc1a8b372b3a00d4a 330 PRINTS PR01039 Tryptophanyl-tRNA synthetase signature 12 28 3.5E-27 T 09-03-2017 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2 TK78_RS12430 1dc066ca4639063cc1a8b372b3a00d4a 330 PRINTS PR01039 Tryptophanyl-tRNA synthetase signature 192 202 3.5E-27 T 09-03-2017 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2 TK78_RS12430 1dc066ca4639063cc1a8b372b3a00d4a 330 PRINTS PR01039 Tryptophanyl-tRNA synthetase signature 62 81 3.5E-27 T 09-03-2017 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2 TK78_RS12430 1dc066ca4639063cc1a8b372b3a00d4a 330 PRINTS PR01039 Tryptophanyl-tRNA synthetase signature 139 160 3.5E-27 T 09-03-2017 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2 TK78_RS12430 1dc066ca4639063cc1a8b372b3a00d4a 330 Gene3D G3DSA:3.40.50.620 1 207 1.8E-88 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS12430 1dc066ca4639063cc1a8b372b3a00d4a 330 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 7 17 - T 09-03-2017 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS12430 1dc066ca4639063cc1a8b372b3a00d4a 330 Pfam PF00579 tRNA synthetases class I (W and Y) 1 280 2.8E-78 T 09-03-2017 IPR002305 Aminoacyl-tRNA synthetase, class Ic GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS12430 1dc066ca4639063cc1a8b372b3a00d4a 330 TIGRFAM TIGR00233 trpS: tryptophan--tRNA ligase 1 325 6.6E-108 T 09-03-2017 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2 TK78_RS26405 f32fbff59aa87c7df9c9b1a6c313d1ec 242 SUPERFAMILY SSF46689 6 81 2.51E-19 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS26405 f32fbff59aa87c7df9c9b1a6c313d1ec 242 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 39 62 1.0E-6 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS26405 f32fbff59aa87c7df9c9b1a6c313d1ec 242 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 18 31 1.0E-6 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS26405 f32fbff59aa87c7df9c9b1a6c313d1ec 242 Pfam PF00440 Bacterial regulatory proteins, tetR family 19 64 3.0E-14 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS26405 f32fbff59aa87c7df9c9b1a6c313d1ec 242 Gene3D G3DSA:1.10.357.10 5 188 3.7E-37 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS26405 f32fbff59aa87c7df9c9b1a6c313d1ec 242 ProSitePatterns PS01081 TetR-type HTH domain signature. 30 60 - T 09-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site TK78_RS12510 775add59fe4703700592b63cb00b3560 433 SUPERFAMILY SSF47413 21 63 2.95E-7 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS12510 775add59fe4703700592b63cb00b3560 433 Gene3D G3DSA:1.10.10.10 253 311 3.5E-7 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS12510 775add59fe4703700592b63cb00b3560 433 Pfam PF01381 Helix-turn-helix 21 57 1.4E-7 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS12510 775add59fe4703700592b63cb00b3560 433 SUPERFAMILY SSF88659 253 309 2.8E-6 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12510 775add59fe4703700592b63cb00b3560 433 Gene3D G3DSA:1.10.1740.10 165 238 8.6E-7 T 09-03-2017 TK78_RS12510 775add59fe4703700592b63cb00b3560 433 SUPERFAMILY SSF88946 165 245 3.61E-7 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12510 775add59fe4703700592b63cb00b3560 433 Gene3D G3DSA:1.10.260.40 21 62 5.8E-11 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS25445 7fcfa8b4eaba28600b9f07d736982c9d 164 Pfam PF11343 Protein of unknown function (DUF3145) 6 162 3.0E-72 T 09-03-2017 IPR021491 Protein of unknown function DUF3145 TK78_RS23935 609f891df221844f80321b519d5d850e 303 Gene3D G3DSA:3.20.20.70 28 291 1.1E-36 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS23935 609f891df221844f80321b519d5d850e 303 SUPERFAMILY SSF51569 30 287 2.09E-35 T 09-03-2017 TK78_RS28570 37a8ad262460dadba92ee4897e207568 343 Pfam PF13242 HAD-hyrolase-like 201 272 2.8E-15 T 09-03-2017 TK78_RS28570 37a8ad262460dadba92ee4897e207568 343 Pfam PF13344 Haloacid dehalogenase-like hydrolase 25 125 6.7E-23 T 09-03-2017 IPR006357 HAD-superfamily hydrolase, subfamily IIA TK78_RS28570 37a8ad262460dadba92ee4897e207568 343 SUPERFAMILY SSF56784 21 274 1.59E-52 T 09-03-2017 IPR023214 HAD-like domain TK78_RS28570 37a8ad262460dadba92ee4897e207568 343 Gene3D G3DSA:3.40.50.10410 94 199 3.7E-26 T 09-03-2017 IPR023215 Nitrophenylphosphatase-like domain TK78_RS28570 37a8ad262460dadba92ee4897e207568 343 TIGRFAM TIGR01460 HAD-SF-IIA: HAD hydrolase, family IIA 25 248 2.6E-30 T 09-03-2017 IPR006357 HAD-superfamily hydrolase, subfamily IIA TK78_RS28570 37a8ad262460dadba92ee4897e207568 343 Gene3D G3DSA:3.40.50.1000 18 93 2.9E-32 T 09-03-2017 IPR023214 HAD-like domain TK78_RS28570 37a8ad262460dadba92ee4897e207568 343 Gene3D G3DSA:3.40.50.1000 200 275 2.9E-32 T 09-03-2017 IPR023214 HAD-like domain TK78_RS20915 4af6ccac49b778022bb5669f7dce8c6e 207 Pfam PF13302 Acetyltransferase (GNAT) domain 8 155 7.8E-17 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS20915 4af6ccac49b778022bb5669f7dce8c6e 207 Gene3D G3DSA:3.40.630.30 1 185 2.6E-59 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS20915 4af6ccac49b778022bb5669f7dce8c6e 207 SUPERFAMILY SSF55729 2 179 1.19E-41 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS18070 d16a596eeda56eae4b491ddbca5ac634 619 SUPERFAMILY SSF56235 1 211 5.4E-43 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS18070 d16a596eeda56eae4b491ddbca5ac634 619 PIRSF PIRSF001589 1 616 5.1E-116 T 09-03-2017 TK78_RS18070 d16a596eeda56eae4b491ddbca5ac634 619 SUPERFAMILY SSF52402 235 388 2.43E-57 T 09-03-2017 TK78_RS18070 d16a596eeda56eae4b491ddbca5ac634 619 SUPERFAMILY SSF52402 449 578 2.43E-57 T 09-03-2017 TK78_RS18070 d16a596eeda56eae4b491ddbca5ac634 619 Gene3D G3DSA:3.60.20.10 1 213 4.0E-50 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS18070 d16a596eeda56eae4b491ddbca5ac634 619 TIGRFAM TIGR01536 asn_synth_AEB: asparagine synthase (glutamine-hydrolyzing) 2 530 5.9E-99 T 09-03-2017 IPR006426 Asparagine synthase, glutamine-hydrolyzing GO:0004066|GO:0006529 KEGG: 00250+6.3.5.4|Reactome: R-HSA-380994|Reactome: R-HSA-70614 TK78_RS18070 d16a596eeda56eae4b491ddbca5ac634 619 Pfam PF13537 Glutamine amidotransferase domain 45 163 2.1E-33 T 09-03-2017 IPR017932 Glutamine amidotransferase type 2 domain TK78_RS18070 d16a596eeda56eae4b491ddbca5ac634 619 Gene3D G3DSA:3.40.50.620 232 405 8.9E-65 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS18070 d16a596eeda56eae4b491ddbca5ac634 619 Gene3D G3DSA:3.40.50.620 445 596 8.9E-65 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS18070 d16a596eeda56eae4b491ddbca5ac634 619 Pfam PF00733 Asparagine synthase 241 597 1.6E-67 T 09-03-2017 IPR001962 Asparagine synthase GO:0004066|GO:0006529 TK78_RS17535 a79dbb87cb9d7f726173c36c32e239db 284 Gene3D G3DSA:2.60.200.20 200 280 6.8E-24 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS17535 a79dbb87cb9d7f726173c36c32e239db 284 Pfam PF00498 FHA domain 212 273 1.7E-14 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS17535 a79dbb87cb9d7f726173c36c32e239db 284 SMART SM00240 210 259 9.0E-11 T 09-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 TK78_RS17535 a79dbb87cb9d7f726173c36c32e239db 284 Pfam PF12401 Protein of unknown function (DUF2662) 5 118 1.5E-41 T 09-03-2017 IPR022128 Protein of unknown function DUF3662 TK78_RS17535 a79dbb87cb9d7f726173c36c32e239db 284 SUPERFAMILY SSF49879 153 280 1.89E-23 T 09-03-2017 IPR008984 SMAD/FHA domain GO:0005515 TK78_RS09945 dcc5f300bfb019e268064f1f77e93628 224 Gene3D G3DSA:3.40.50.300 47 150 4.1E-11 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09945 dcc5f300bfb019e268064f1f77e93628 224 SUPERFAMILY SSF52540 47 220 2.53E-19 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09945 dcc5f300bfb019e268064f1f77e93628 224 Pfam PF03029 Conserved hypothetical ATP binding protein 52 219 1.8E-25 T 09-03-2017 IPR004130 GPN-loop GTPase TK78_RS20250 267a0973110021a588ff55c5175ab141 360 Pfam PF01578 Cytochrome C assembly protein 139 355 1.9E-45 T 09-03-2017 IPR002541 Cytochrome c assembly protein GO:0017004|GO:0020037 TK78_RS20250 267a0973110021a588ff55c5175ab141 360 TIGRFAM TIGR03144 cytochr_II_ccsB: cytochrome c-type biogenesis protein CcsB 116 358 1.3E-78 T 09-03-2017 IPR017562 Cytochrome c-type biogenesis protein CcsA GO:0017004 TK78_RS26575 9da390da8313c308459b84fbd4ffb042 325 Gene3D G3DSA:3.20.20.70 39 310 7.7E-63 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS26575 9da390da8313c308459b84fbd4ffb042 325 Pfam PF16881 N-terminal domain of lipoyl synthase of Radical_SAM family 24 61 1.7E-6 T 09-03-2017 IPR031691 Lipoyl synthase, N-terminal KEGG: 00785+2.8.1.8|MetaCyc: PWY-6987|MetaCyc: PWY-7382|Reactome: R-HSA-389661 TK78_RS26575 9da390da8313c308459b84fbd4ffb042 325 PIRSF PIRSF005963 3 323 5.0E-119 T 09-03-2017 IPR003698 Lipoyl synthase GO:0009107|GO:0016992|GO:0051539 KEGG: 00785+2.8.1.8|MetaCyc: PWY-6987|MetaCyc: PWY-7382|Reactome: R-HSA-389661 TK78_RS26575 9da390da8313c308459b84fbd4ffb042 325 TIGRFAM TIGR00510 lipA: lipoyl synthase 18 310 1.2E-94 T 09-03-2017 IPR003698 Lipoyl synthase GO:0009107|GO:0016992|GO:0051539 KEGG: 00785+2.8.1.8|MetaCyc: PWY-6987|MetaCyc: PWY-7382|Reactome: R-HSA-389661 TK78_RS26575 9da390da8313c308459b84fbd4ffb042 325 SMART SM00729 72 286 7.8E-15 T 09-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 TK78_RS26575 9da390da8313c308459b84fbd4ffb042 325 Pfam PF04055 Radical SAM superfamily 82 241 5.3E-12 T 09-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 TK78_RS26575 9da390da8313c308459b84fbd4ffb042 325 Hamap MF_00206 Lipoyl synthase [lipA]. 1 313 134.924 T 09-03-2017 IPR003698 Lipoyl synthase GO:0009107|GO:0016992|GO:0051539 KEGG: 00785+2.8.1.8|MetaCyc: PWY-6987|MetaCyc: PWY-7382|Reactome: R-HSA-389661 TK78_RS26575 9da390da8313c308459b84fbd4ffb042 325 SUPERFAMILY SSF102114 36 306 9.55E-59 T 09-03-2017 TK78_RS00915 04184e975b5a1e3fe68dcbaece95aa41 172 SUPERFAMILY SSF55961 1 165 4.08E-26 T 09-03-2017 TK78_RS00915 04184e975b5a1e3fe68dcbaece95aa41 172 Pfam PF10604 Polyketide cyclase / dehydrase and lipid transport 6 164 1.3E-23 T 09-03-2017 IPR019587 Polyketide cyclase/dehydrase TK78_RS00915 04184e975b5a1e3fe68dcbaece95aa41 172 Gene3D G3DSA:3.30.530.20 6 165 1.5E-18 T 09-03-2017 IPR023393 START-like domain TK78_RS20315 051cb70fd6aaa18631b5ba5cf12fc2ef 214 SUPERFAMILY SSF46689 7 85 3.03E-19 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS20315 051cb70fd6aaa18631b5ba5cf12fc2ef 214 SUPERFAMILY SSF48498 89 201 2.67E-5 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS20315 051cb70fd6aaa18631b5ba5cf12fc2ef 214 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 18 31 2.1E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS20315 051cb70fd6aaa18631b5ba5cf12fc2ef 214 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 39 62 2.1E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS20315 051cb70fd6aaa18631b5ba5cf12fc2ef 214 Pfam PF00440 Bacterial regulatory proteins, tetR family 19 64 2.9E-16 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS20315 051cb70fd6aaa18631b5ba5cf12fc2ef 214 Gene3D G3DSA:1.10.357.10 6 202 1.3E-44 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS19170 7317cbdd75fce86305857608eaf27979 311 Pfam PF02668 Taurine catabolism dioxygenase TauD, TfdA family 12 301 3.5E-22 T 09-03-2017 IPR003819 TauD/TfdA-like domain GO:0016491|GO:0055114 Reactome: R-HSA-71262 TK78_RS19170 7317cbdd75fce86305857608eaf27979 311 Gene3D G3DSA:3.60.130.10 190 299 5.4E-42 T 09-03-2017 TK78_RS19170 7317cbdd75fce86305857608eaf27979 311 Gene3D G3DSA:3.60.130.10 8 158 5.4E-42 T 09-03-2017 TK78_RS19170 7317cbdd75fce86305857608eaf27979 311 SUPERFAMILY SSF51197 21 300 6.41E-51 T 09-03-2017 TK78_RS24145 c059f8da53ee39516164526e1b500e06 303 Gene3D G3DSA:1.10.3720.10 27 290 4.6E-70 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS24145 c059f8da53ee39516164526e1b500e06 303 SUPERFAMILY SSF161098 31 303 5.7E-73 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS24145 c059f8da53ee39516164526e1b500e06 303 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 115 296 5.4E-22 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS34310 5d4a934ed8ef42e77fdec068510fd209 329 PRINTS PR00111 Alpha/beta hydrolase fold signature 102 115 4.7E-5 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS34310 5d4a934ed8ef42e77fdec068510fd209 329 PRINTS PR00111 Alpha/beta hydrolase fold signature 116 129 4.7E-5 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS34310 5d4a934ed8ef42e77fdec068510fd209 329 PRINTS PR00111 Alpha/beta hydrolase fold signature 56 71 4.7E-5 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS34310 5d4a934ed8ef42e77fdec068510fd209 329 Pfam PF00561 alpha/beta hydrolase fold 30 312 1.5E-28 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS34310 5d4a934ed8ef42e77fdec068510fd209 329 Gene3D G3DSA:3.40.50.1820 219 326 6.4E-84 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS34310 5d4a934ed8ef42e77fdec068510fd209 329 Gene3D G3DSA:3.40.50.1820 6 187 6.4E-84 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS34310 5d4a934ed8ef42e77fdec068510fd209 329 PRINTS PR00412 Epoxide hydrolase signature 36 54 8.5E-28 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS34310 5d4a934ed8ef42e77fdec068510fd209 329 PRINTS PR00412 Epoxide hydrolase signature 116 129 8.5E-28 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS34310 5d4a934ed8ef42e77fdec068510fd209 329 PRINTS PR00412 Epoxide hydrolase signature 56 71 8.5E-28 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS34310 5d4a934ed8ef42e77fdec068510fd209 329 PRINTS PR00412 Epoxide hydrolase signature 102 115 8.5E-28 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS34310 5d4a934ed8ef42e77fdec068510fd209 329 PRINTS PR00412 Epoxide hydrolase signature 301 323 8.5E-28 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS34310 5d4a934ed8ef42e77fdec068510fd209 329 SUPERFAMILY SSF53474 9 189 5.97E-68 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS34310 5d4a934ed8ef42e77fdec068510fd209 329 SUPERFAMILY SSF53474 219 325 5.97E-68 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS19690 b5d342ff55cb9f00e034245628b575a2 245 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 43 220 5.9E-22 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS19690 b5d342ff55cb9f00e034245628b575a2 245 SUPERFAMILY SSF161098 23 206 1.57E-34 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS19690 b5d342ff55cb9f00e034245628b575a2 245 Gene3D G3DSA:1.10.3720.10 19 204 1.4E-28 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS16380 9d0637af9e6a0d66ec4982e0c1af0c8a 146 Pfam PF00582 Universal stress protein family 3 136 2.4E-21 T 09-03-2017 IPR006016 UspA GO:0006950 TK78_RS16380 9d0637af9e6a0d66ec4982e0c1af0c8a 146 SUPERFAMILY SSF52402 2 139 7.67E-28 T 09-03-2017 TK78_RS16380 9d0637af9e6a0d66ec4982e0c1af0c8a 146 PRINTS PR01438 Universal stress protein signature 114 136 3.0E-6 T 09-03-2017 IPR006015 Universal stress protein A TK78_RS16380 9d0637af9e6a0d66ec4982e0c1af0c8a 146 PRINTS PR01438 Universal stress protein signature 96 108 3.0E-6 T 09-03-2017 IPR006015 Universal stress protein A TK78_RS16380 9d0637af9e6a0d66ec4982e0c1af0c8a 146 Gene3D G3DSA:3.40.50.620 3 138 1.4E-30 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS05965 6f42cfc697578afba306f6c680db564b 371 SUPERFAMILY SSF89372 36 332 4.71E-16 T 09-03-2017 TK78_RS25250 8d84dd1dc9921e0d6d516652629aec0b 363 PRINTS PR00046 Major sigma-70 factor signature 302 314 1.2E-29 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS25250 8d84dd1dc9921e0d6d516652629aec0b 363 PRINTS PR00046 Major sigma-70 factor signature 323 338 1.2E-29 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS25250 8d84dd1dc9921e0d6d516652629aec0b 363 PRINTS PR00046 Major sigma-70 factor signature 178 186 1.2E-29 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS25250 8d84dd1dc9921e0d6d516652629aec0b 363 PRINTS PR00046 Major sigma-70 factor signature 338 349 1.2E-29 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS25250 8d84dd1dc9921e0d6d516652629aec0b 363 PRINTS PR00046 Major sigma-70 factor signature 154 167 1.2E-29 T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS25250 8d84dd1dc9921e0d6d516652629aec0b 363 SUPERFAMILY SSF88946 62 200 1.02E-51 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS25250 8d84dd1dc9921e0d6d516652629aec0b 363 Pfam PF04542 Sigma-70 region 2 130 199 1.4E-23 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS25250 8d84dd1dc9921e0d6d516652629aec0b 363 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 126 351 7.8E-38 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS25250 8d84dd1dc9921e0d6d516652629aec0b 363 Pfam PF04545 Sigma-70, region 4 298 351 3.2E-19 T 09-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS25250 8d84dd1dc9921e0d6d516652629aec0b 363 Pfam PF00140 Sigma-70 factor, region 1.2 65 98 1.6E-16 T 09-03-2017 IPR009042 RNA polymerase sigma-70 region 1.2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS25250 8d84dd1dc9921e0d6d516652629aec0b 363 Pfam PF04539 Sigma-70 region 3 209 285 9.7E-26 T 09-03-2017 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS25250 8d84dd1dc9921e0d6d516652629aec0b 363 ProSitePatterns PS00716 Sigma-70 factors family signature 2. 323 349 - T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS25250 8d84dd1dc9921e0d6d516652629aec0b 363 Gene3D G3DSA:1.10.601.10 53 199 1.3E-63 T 09-03-2017 TK78_RS25250 8d84dd1dc9921e0d6d516652629aec0b 363 SUPERFAMILY SSF88659 203 276 7.85E-19 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS25250 8d84dd1dc9921e0d6d516652629aec0b 363 Gene3D G3DSA:1.10.10.10 203 254 2.8E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS25250 8d84dd1dc9921e0d6d516652629aec0b 363 ProSitePatterns PS00715 Sigma-70 factors family signature 1. 154 167 - T 09-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS25250 8d84dd1dc9921e0d6d516652629aec0b 363 SUPERFAMILY SSF88659 261 359 4.86E-28 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS25250 8d84dd1dc9921e0d6d516652629aec0b 363 Gene3D G3DSA:1.10.10.10 292 363 3.0E-28 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS24640 d387cf4d6bf0694a2ca2a0f41c2396bb 955 SUPERFAMILY SSF50677 295 514 1.2E-41 T 09-03-2017 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 TK78_RS24640 d387cf4d6bf0694a2ca2a0f41c2396bb 955 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 68 78 - T 09-03-2017 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS24640 d387cf4d6bf0694a2ca2a0f41c2396bb 955 TIGRFAM TIGR00396 leuS_bact: leucine--tRNA ligase 218 953 4.5E-214 T 09-03-2017 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 TK78_RS24640 d387cf4d6bf0694a2ca2a0f41c2396bb 955 SUPERFAMILY SSF47323 770 953 5.42E-29 T 09-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS24640 d387cf4d6bf0694a2ca2a0f41c2396bb 955 SUPERFAMILY SSF52374 23 172 1.54E-109 T 09-03-2017 TK78_RS24640 d387cf4d6bf0694a2ca2a0f41c2396bb 955 SUPERFAMILY SSF52374 511 774 1.54E-109 T 09-03-2017 TK78_RS24640 d387cf4d6bf0694a2ca2a0f41c2396bb 955 SUPERFAMILY SSF52374 220 298 1.54E-109 T 09-03-2017 TK78_RS24640 d387cf4d6bf0694a2ca2a0f41c2396bb 955 Pfam PF08264 Anticodon-binding domain of tRNA 804 916 9.9E-15 T 09-03-2017 IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding GO:0000166|GO:0006418 TK78_RS24640 d387cf4d6bf0694a2ca2a0f41c2396bb 955 Gene3D G3DSA:1.10.730.10 755 890 5.2E-33 T 09-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS24640 d387cf4d6bf0694a2ca2a0f41c2396bb 955 Hamap MF_00049_B Leucine--tRNA ligase [leuS]. 18 954 21.044 T 09-03-2017 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 TK78_RS24640 d387cf4d6bf0694a2ca2a0f41c2396bb 955 Pfam PF09334 tRNA synthetases class I (M) 65 168 1.1E-12 T 09-03-2017 IPR015413 Methionyl/Leucyl tRNA synthetase GO:0000166|GO:0004812|GO:0005524|GO:0006418 TK78_RS24640 d387cf4d6bf0694a2ca2a0f41c2396bb 955 Gene3D G3DSA:3.40.50.620 219 295 2.1E-133 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS24640 d387cf4d6bf0694a2ca2a0f41c2396bb 955 Gene3D G3DSA:3.40.50.620 22 171 2.1E-133 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS24640 d387cf4d6bf0694a2ca2a0f41c2396bb 955 Gene3D G3DSA:3.40.50.620 520 692 2.1E-133 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS24640 d387cf4d6bf0694a2ca2a0f41c2396bb 955 Gene3D G3DSA:3.40.50.620 725 754 2.1E-133 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS24640 d387cf4d6bf0694a2ca2a0f41c2396bb 955 PRINTS PR00985 Leucyl-tRNA synthetase signature 643 665 8.6E-51 T 09-03-2017 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 TK78_RS24640 d387cf4d6bf0694a2ca2a0f41c2396bb 955 PRINTS PR00985 Leucyl-tRNA synthetase signature 225 241 8.6E-51 T 09-03-2017 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 TK78_RS24640 d387cf4d6bf0694a2ca2a0f41c2396bb 955 PRINTS PR00985 Leucyl-tRNA synthetase signature 595 613 8.6E-51 T 09-03-2017 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 TK78_RS24640 d387cf4d6bf0694a2ca2a0f41c2396bb 955 PRINTS PR00985 Leucyl-tRNA synthetase signature 676 686 8.6E-51 T 09-03-2017 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 TK78_RS24640 d387cf4d6bf0694a2ca2a0f41c2396bb 955 PRINTS PR00985 Leucyl-tRNA synthetase signature 152 169 8.6E-51 T 09-03-2017 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 TK78_RS24640 d387cf4d6bf0694a2ca2a0f41c2396bb 955 PRINTS PR00985 Leucyl-tRNA synthetase signature 258 271 8.6E-51 T 09-03-2017 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 TK78_RS24640 d387cf4d6bf0694a2ca2a0f41c2396bb 955 PRINTS PR00985 Leucyl-tRNA synthetase signature 287 306 8.6E-51 T 09-03-2017 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 TK78_RS24640 d387cf4d6bf0694a2ca2a0f41c2396bb 955 Pfam PF13603 Leucyl-tRNA synthetase, Domain 2 293 498 2.0E-59 T 09-03-2017 IPR025709 Leucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 KEGG: 00970+6.1.1.4 TK78_RS24640 d387cf4d6bf0694a2ca2a0f41c2396bb 955 Gene3D G3DSA:3.90.740.10 296 519 7.5E-50 T 09-03-2017 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 TK78_RS10850 07211f2dd264206cc07aaa2f006c1f29 331 Pfam PF00583 Acetyltransferase (GNAT) family 263 319 4.1E-11 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS10850 07211f2dd264206cc07aaa2f006c1f29 331 Gene3D G3DSA:3.40.630.30 234 329 1.6E-16 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS10850 07211f2dd264206cc07aaa2f006c1f29 331 SUPERFAMILY SSF55729 204 329 1.62E-17 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS18540 325843719cb8cc5d19891f60a469ce2d 534 SUPERFAMILY SSF52540 269 511 6.37E-5 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS04810 71483ba5bdbc54665ee604f5698072bf 388 TIGRFAM TIGR00744 ROK_glcA_fam: ROK family protein (putative glucokinase) 38 347 1.0E-92 T 09-03-2017 IPR004654 Glucokinase ROK GO:0004340|GO:0005737|GO:0006096|GO:0051156 KEGG: 00010+2.7.1.2|KEGG: 00052+2.7.1.2|KEGG: 00500+2.7.1.2|KEGG: 00520+2.7.1.2|KEGG: 00521+2.7.1.2|KEGG: 00524+2.7.1.2|MetaCyc: PWY-2722|MetaCyc: PWY-2723|MetaCyc: PWY-5514|MetaCyc: PWY-5661|MetaCyc: PWY-621|MetaCyc: PWY-7238|MetaCyc: PWY-7385 TK78_RS04810 71483ba5bdbc54665ee604f5698072bf 388 Gene3D G3DSA:3.30.420.40 172 320 5.9E-52 T 09-03-2017 TK78_RS04810 71483ba5bdbc54665ee604f5698072bf 388 Gene3D G3DSA:3.30.420.40 37 171 2.8E-43 T 09-03-2017 TK78_RS04810 71483ba5bdbc54665ee604f5698072bf 388 Pfam PF00480 ROK family 37 347 2.5E-81 T 09-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 TK78_RS04810 71483ba5bdbc54665ee604f5698072bf 388 ProSitePatterns PS01125 ROK family signature. 166 193 - T 09-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 TK78_RS04810 71483ba5bdbc54665ee604f5698072bf 388 SUPERFAMILY SSF53067 37 348 3.63E-68 T 09-03-2017 TK78_RS25415 5c239290616d154f391f22b38ea3e64a 339 SMART SM00829 23 336 1.4E-6 T 09-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 TK78_RS25415 5c239290616d154f391f22b38ea3e64a 339 Pfam PF00107 Zinc-binding dehydrogenase 162 290 1.0E-21 T 09-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 TK78_RS25415 5c239290616d154f391f22b38ea3e64a 339 Gene3D G3DSA:3.40.50.720 145 306 1.2E-70 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS25415 5c239290616d154f391f22b38ea3e64a 339 Pfam PF16884 N-terminal domain of oxidoreductase 10 114 1.1E-38 T 09-03-2017 TK78_RS25415 5c239290616d154f391f22b38ea3e64a 339 SUPERFAMILY SSF50129 7 145 1.48E-39 T 09-03-2017 IPR011032 GroES-like TK78_RS25415 5c239290616d154f391f22b38ea3e64a 339 SUPERFAMILY SSF51735 127 303 2.47E-49 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS25415 5c239290616d154f391f22b38ea3e64a 339 Gene3D G3DSA:3.90.180.10 6 144 1.0E-52 T 09-03-2017 IPR011032 GroES-like TK78_RS25710 f2a94cb78facb82292f35c2b05a5b626 74 Pfam PF10041 Uncharacterized conserved protein (DUF2277) 1 70 3.2E-27 T 09-03-2017 IPR018735 Protein of unknown function DUF2277 TK78_RS14770 416f1407ddbde321064d0b2ebe1787e6 304 TIGRFAM TIGR00724 urea_amlyse_rel: biotin-dependent carboxylase uncharacterized domain 22 303 3.6E-76 T 09-03-2017 IPR003778 Carboxyltransferase domain, subdomain A and B TK78_RS14770 416f1407ddbde321064d0b2ebe1787e6 304 SMART SM00797 43 304 4.3E-89 T 09-03-2017 IPR003778 Carboxyltransferase domain, subdomain A and B TK78_RS14770 416f1407ddbde321064d0b2ebe1787e6 304 Pfam PF02626 Allophanate hydrolase subunit 2 44 302 4.7E-81 T 09-03-2017 IPR003778 Carboxyltransferase domain, subdomain A and B TK78_RS14770 416f1407ddbde321064d0b2ebe1787e6 304 Gene3D G3DSA:2.40.100.10 194 303 2.0E-8 T 09-03-2017 IPR029000 Cyclophilin-like domain TK78_RS14770 416f1407ddbde321064d0b2ebe1787e6 304 SUPERFAMILY SSF50891 194 303 5.31E-13 T 09-03-2017 IPR029000 Cyclophilin-like domain TK78_RS09755 3cfa64ef40e1a6e6059462ab164aa21b 681 SUPERFAMILY SSF50249 307 381 9.42E-18 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS09755 3cfa64ef40e1a6e6059462ab164aa21b 681 SMART SM00357 308 374 1.1E-11 T 09-03-2017 IPR011129 Cold shock protein GO:0003676 TK78_RS09755 3cfa64ef40e1a6e6059462ab164aa21b 681 Pfam PF00006 ATP synthase alpha/beta family, nucleotide-binding domain 412 616 5.4E-20 T 09-03-2017 IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain GO:0005524 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 TK78_RS09755 3cfa64ef40e1a6e6059462ab164aa21b 681 Hamap MF_01884 Transcription termination factor Rho [rho]. 299 672 203.453 T 09-03-2017 IPR004665 Transcription termination factor Rho GO:0003723|GO:0005524|GO:0006353|GO:0008186 TK78_RS09755 3cfa64ef40e1a6e6059462ab164aa21b 681 Pfam PF07498 Rho termination factor, N-terminal domain 40 77 2.7E-11 T 09-03-2017 IPR011112 Rho termination factor, N-terminal GO:0006353 TK78_RS09755 3cfa64ef40e1a6e6059462ab164aa21b 681 SMART SM00382 423 608 3.3E-8 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS09755 3cfa64ef40e1a6e6059462ab164aa21b 681 SUPERFAMILY SSF52540 345 623 1.25E-66 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09755 3cfa64ef40e1a6e6059462ab164aa21b 681 TIGRFAM TIGR00767 rho: transcription termination factor Rho 40 670 1.3E-198 T 09-03-2017 IPR004665 Transcription termination factor Rho GO:0003723|GO:0005524|GO:0006353|GO:0008186 TK78_RS09755 3cfa64ef40e1a6e6059462ab164aa21b 681 SMART SM00959 39 80 8.7E-11 T 09-03-2017 IPR011112 Rho termination factor, N-terminal GO:0006353 TK78_RS09755 3cfa64ef40e1a6e6059462ab164aa21b 681 SUPERFAMILY SSF68912 39 78 5.89E-5 T 09-03-2017 IPR011112 Rho termination factor, N-terminal GO:0006353 TK78_RS09755 3cfa64ef40e1a6e6059462ab164aa21b 681 Gene3D G3DSA:2.40.50.140 302 381 6.7E-42 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS09755 3cfa64ef40e1a6e6059462ab164aa21b 681 Gene3D G3DSA:2.40.50.140 39 79 6.7E-42 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS09755 3cfa64ef40e1a6e6059462ab164aa21b 681 Pfam PF07497 Rho termination factor, RNA-binding domain 307 381 7.3E-30 T 09-03-2017 IPR011113 Rho termination factor, RNA-binding GO:0003723|GO:0006353 TK78_RS09755 3cfa64ef40e1a6e6059462ab164aa21b 681 Gene3D G3DSA:3.40.50.300 387 670 3.6E-98 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09600 e87ec5e1258b0b79e49f2681a645939b 223 Hamap MF_00722 Endonuclease NucS [nucS]. 1 215 31.902 T 09-03-2017 IPR002793 Endonuclease NucS TK78_RS09600 e87ec5e1258b0b79e49f2681a645939b 223 Pfam PF01939 Protein of unknown function DUF91 2 223 1.9E-85 T 09-03-2017 IPR002793 Endonuclease NucS TK78_RS20455 326fb2f6630fc8d68832d68a674c1574 374 Pfam PF00296 Luciferase-like monooxygenase 25 329 5.3E-42 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS20455 326fb2f6630fc8d68832d68a674c1574 374 Gene3D G3DSA:3.20.20.30 2 359 1.1E-75 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS20455 326fb2f6630fc8d68832d68a674c1574 374 SUPERFAMILY SSF51679 2 358 3.14E-65 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS22115 5245cd46680ad416e5eab3f8cace420c 395 Pfam PF06224 Winged helix DNA-binding domain 40 362 1.2E-65 T 09-03-2017 IPR009351 Protein of unknown function DUF1006 TK78_RS32160 9cbc72aa26b0bafa391634d334d4f220 175 Pfam PF13302 Acetyltransferase (GNAT) domain 7 148 7.4E-16 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS32160 9cbc72aa26b0bafa391634d334d4f220 175 SUPERFAMILY SSF55729 6 171 3.47E-33 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS32160 9cbc72aa26b0bafa391634d334d4f220 175 Gene3D G3DSA:3.40.630.30 6 170 1.7E-35 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS31645 793ec1976647a11a3b7ef4358bec2e1f 350 Gene3D G3DSA:3.40.50.720 8 306 8.3E-27 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31645 793ec1976647a11a3b7ef4358bec2e1f 350 Pfam PF13460 NAD(P)H-binding 10 80 1.4E-6 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31645 793ec1976647a11a3b7ef4358bec2e1f 350 SUPERFAMILY SSF51735 1 310 7.54E-36 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS24705 b0b0a3e584f0a63da828d84d361a60a3 162 Pfam PF09335 SNARE associated Golgi protein 9 108 4.1E-9 T 09-03-2017 IPR032816 SNARE associated Golgi protein TK78_RS18485 a5da6aeb727d2e97d34db976af81480f 448 Pfam PF07690 Major Facilitator Superfamily 11 245 3.4E-16 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS18485 a5da6aeb727d2e97d34db976af81480f 448 SUPERFAMILY SSF103473 8 398 3.79E-44 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS18485 a5da6aeb727d2e97d34db976af81480f 448 Gene3D G3DSA:1.20.1250.20 10 182 2.7E-21 T 09-03-2017 TK78_RS18485 a5da6aeb727d2e97d34db976af81480f 448 Gene3D G3DSA:1.20.1250.20 216 393 1.1E-15 T 09-03-2017 TK78_RS20070 32cf7b239a252c08b261bb5e9ceac3ed 261 Pfam PF13560 Helix-turn-helix domain 5 60 1.6E-10 T 09-03-2017 TK78_RS20070 32cf7b239a252c08b261bb5e9ceac3ed 261 Gene3D G3DSA:1.10.260.40 4 58 3.3E-11 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS20070 32cf7b239a252c08b261bb5e9ceac3ed 261 SMART SM00530 7 62 9.0E-8 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS20070 32cf7b239a252c08b261bb5e9ceac3ed 261 SUPERFAMILY SSF47413 2 58 3.94E-10 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS30460 b98937da6d94c963c07b0e2a870965f5 202 Pfam PF00677 Lumazine binding domain 3 85 2.0E-23 T 09-03-2017 IPR026017 Lumazine-binding domain KEGG: 00740+2.5.1.9|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TK78_RS30460 b98937da6d94c963c07b0e2a870965f5 202 Pfam PF00677 Lumazine binding domain 99 183 2.0E-24 T 09-03-2017 IPR026017 Lumazine-binding domain KEGG: 00740+2.5.1.9|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TK78_RS30460 b98937da6d94c963c07b0e2a870965f5 202 SUPERFAMILY SSF63380 2 87 1.79E-24 T 09-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 TK78_RS30460 b98937da6d94c963c07b0e2a870965f5 202 TIGRFAM TIGR00187 ribE: riboflavin synthase, alpha subunit 2 194 9.3E-62 T 09-03-2017 IPR001783 Lumazine-binding protein KEGG: 00740+2.5.1.9|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TK78_RS30460 b98937da6d94c963c07b0e2a870965f5 202 SUPERFAMILY SSF63380 92 195 7.99E-34 T 09-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 TK78_RS30460 b98937da6d94c963c07b0e2a870965f5 202 PIRSF PIRSF000498 1 202 1.6E-71 T 09-03-2017 IPR001783 Lumazine-binding protein KEGG: 00740+2.5.1.9|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TK78_RS30460 b98937da6d94c963c07b0e2a870965f5 202 Gene3D G3DSA:2.40.30.20 104 194 2.2E-32 T 09-03-2017 IPR023366 ATP synthase subunit alpha-like domain KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219|Reactome: R-HSA-1268020|Reactome: R-HSA-163210 TK78_RS30460 b98937da6d94c963c07b0e2a870965f5 202 Gene3D G3DSA:2.40.30.20 5 103 7.9E-34 T 09-03-2017 IPR023366 ATP synthase subunit alpha-like domain KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219|Reactome: R-HSA-1268020|Reactome: R-HSA-163210 TK78_RS15530 19aed99f651ba5a971e2e00a4a7e2449 62 Gene3D G3DSA:2.10.230.10 17 60 3.1E-5 T 09-03-2017 IPR001305 Heat shock protein DnaJ, cysteine-rich domain GO:0031072|GO:0051082 TK78_RS15530 19aed99f651ba5a971e2e00a4a7e2449 62 SUPERFAMILY SSF57938 16 59 3.53E-5 T 09-03-2017 IPR001305 Heat shock protein DnaJ, cysteine-rich domain GO:0031072|GO:0051082 TK78_RS04570 7f4eb638d6921bea614a94d479c28ec0 289 Gene3D G3DSA:3.40.1010.10 9 152 7.3E-37 T 09-03-2017 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS04570 7f4eb638d6921bea614a94d479c28ec0 289 SUPERFAMILY SSF53790 8 258 9.89E-34 T 09-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS04570 7f4eb638d6921bea614a94d479c28ec0 289 Gene3D G3DSA:3.30.950.10 153 260 1.4E-47 T 09-03-2017 IPR014776 Tetrapyrrole methylase, subdomain 2 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS04570 7f4eb638d6921bea614a94d479c28ec0 289 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 11 233 1.2E-27 T 09-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 TK78_RS04570 7f4eb638d6921bea614a94d479c28ec0 289 PIRSF PIRSF036525 8 264 5.2E-106 T 09-03-2017 IPR012797 Cobalamin (vitamin B12) biosynthesis CobF, precorrin-6A synthase GO:0009236|GO:0043819 KEGG: 00860+2.1.1.152|MetaCyc: PWY-7376 TK78_RS04570 7f4eb638d6921bea614a94d479c28ec0 289 TIGRFAM TIGR02434 CobF: precorrin-6A synthase (deacetylating) 9 259 9.3E-101 T 09-03-2017 IPR012797 Cobalamin (vitamin B12) biosynthesis CobF, precorrin-6A synthase GO:0009236|GO:0043819 KEGG: 00860+2.1.1.152|MetaCyc: PWY-7376 TK78_RS28500 70176e366d564fa7a8a0dfa002520755 265 Pfam PF00005 ABC transporter 21 173 5.5E-26 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS28500 70176e366d564fa7a8a0dfa002520755 265 SMART SM00382 29 224 1.4E-10 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS28500 70176e366d564fa7a8a0dfa002520755 265 Gene3D G3DSA:3.40.50.300 2 238 2.2E-50 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28500 70176e366d564fa7a8a0dfa002520755 265 SUPERFAMILY SSF52540 4 237 2.19E-49 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09880 9df077b13263619d4e566e04d250bb0e 460 SMART SM00388 229 287 9.8E-14 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS09880 9df077b13263619d4e566e04d250bb0e 460 Pfam PF00672 HAMP domain 150 225 2.7E-12 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS09880 9df077b13263619d4e566e04d250bb0e 460 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 325 424 9.6E-9 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09880 9df077b13263619d4e566e04d250bb0e 460 Pfam PF00512 His Kinase A (phospho-acceptor) domain 231 286 3.9E-12 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS09880 9df077b13263619d4e566e04d250bb0e 460 SMART SM00387 325 426 6.5E-16 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09880 9df077b13263619d4e566e04d250bb0e 460 SUPERFAMILY SSF158472 170 225 1.83E-5 T 09-03-2017 TK78_RS09880 9df077b13263619d4e566e04d250bb0e 460 SMART SM00304 169 228 2.9E-7 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS09880 9df077b13263619d4e566e04d250bb0e 460 Gene3D G3DSA:3.30.565.10 274 423 2.1E-19 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09880 9df077b13263619d4e566e04d250bb0e 460 SUPERFAMILY SSF47384 213 286 1.59E-13 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS09880 9df077b13263619d4e566e04d250bb0e 460 SUPERFAMILY SSF55874 276 424 1.44E-22 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09880 9df077b13263619d4e566e04d250bb0e 460 Gene3D G3DSA:1.10.287.130 219 273 5.3E-14 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS33730 1230d5d2265f1e01965e2eaa40aa9c02 730 SUPERFAMILY SSF49785 47 173 1.63E-32 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS33730 1230d5d2265f1e01965e2eaa40aa9c02 730 SUPERFAMILY SSF51126 554 670 1.65E-5 T 09-03-2017 IPR011050 Pectin lyase fold/virulence factor TK78_RS33730 1230d5d2265f1e01965e2eaa40aa9c02 730 SUPERFAMILY SSF51126 432 506 1.65E-5 T 09-03-2017 IPR011050 Pectin lyase fold/virulence factor TK78_RS33730 1230d5d2265f1e01965e2eaa40aa9c02 730 Pfam PF00754 F5/8 type C domain 56 168 2.0E-25 T 09-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain TK78_RS33730 1230d5d2265f1e01965e2eaa40aa9c02 730 Gene3D G3DSA:2.60.120.260 42 176 4.4E-36 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS20765 fe8192c534b37140bf619a2cee706742 424 Gene3D G3DSA:3.40.50.980 206 238 2.0E-26 T 09-03-2017 TK78_RS20765 fe8192c534b37140bf619a2cee706742 424 Gene3D G3DSA:3.40.50.980 61 173 2.0E-26 T 09-03-2017 TK78_RS20765 fe8192c534b37140bf619a2cee706742 424 SUPERFAMILY SSF56801 58 421 1.57E-63 T 09-03-2017 TK78_RS20765 fe8192c534b37140bf619a2cee706742 424 Pfam PF00501 AMP-binding enzyme 322 421 8.6E-25 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS20765 fe8192c534b37140bf619a2cee706742 424 Pfam PF00501 AMP-binding enzyme 65 313 1.8E-32 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS20765 fe8192c534b37140bf619a2cee706742 424 Gene3D G3DSA:2.30.38.10 348 420 8.3E-24 T 09-03-2017 TK78_RS20765 fe8192c534b37140bf619a2cee706742 424 Gene3D G3DSA:3.40.50.980 239 310 2.8E-6 T 09-03-2017 TK78_RS27860 cdc322ddec27ce6433b4b74eadfcd2a6 344 Gene3D G3DSA:3.40.50.10680 102 335 1.7E-44 T 09-03-2017 TK78_RS27860 cdc322ddec27ce6433b4b74eadfcd2a6 344 SUPERFAMILY SSF142338 26 330 4.45E-84 T 09-03-2017 TK78_RS27860 cdc322ddec27ce6433b4b74eadfcd2a6 344 Hamap MF_00973 Gluconeogenesis factor. 25 336 32.625 T 09-03-2017 IPR010119 Gluconeogenesis factor TK78_RS27860 cdc322ddec27ce6433b4b74eadfcd2a6 344 TIGRFAM TIGR01826 CofD_related: conserved hypothetical protein 29 296 3.4E-84 T 09-03-2017 IPR010119 Gluconeogenesis factor TK78_RS27860 cdc322ddec27ce6433b4b74eadfcd2a6 344 Pfam PF01933 Uncharacterised protein family UPF0052 29 298 3.0E-72 T 09-03-2017 IPR002882 LPPG:FO 2-phospho-L-lactate transferase CofD/UPF0052 TK78_RS21310 5afe778eb744dbb2ec9c5aa554eb4c0a 270 Hamap MF_00560 Trans-aconitate 2-methyltransferase [tam]. 7 269 42.56 T 09-03-2017 IPR023506 Trans-aconitate 2-methyltransferase GO:0030798 KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6936|MetaCyc: PWY-702 TK78_RS21310 5afe778eb744dbb2ec9c5aa554eb4c0a 270 Gene3D G3DSA:3.40.50.150 9 187 2.0E-31 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS21310 5afe778eb744dbb2ec9c5aa554eb4c0a 270 SUPERFAMILY SSF53335 25 217 1.23E-29 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS21310 5afe778eb744dbb2ec9c5aa554eb4c0a 270 Gene3D G3DSA:1.10.150.290 193 250 7.3E-26 T 09-03-2017 IPR023149 Trans-aconitate 2-methyltransferase, C-terminal GO:0030798 KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6936|MetaCyc: PWY-702 TK78_RS21310 5afe778eb744dbb2ec9c5aa554eb4c0a 270 Pfam PF13649 Methyltransferase domain 44 135 8.7E-14 T 09-03-2017 TK78_RS31345 cf673730ec99171ae26ba87396d94919 249 Gene3D G3DSA:2.160.10.10 65 212 4.8E-36 T 09-03-2017 TK78_RS31345 cf673730ec99171ae26ba87396d94919 249 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 158 190 1.5E-9 T 09-03-2017 IPR001451 Hexapeptide repeat TK78_RS31345 cf673730ec99171ae26ba87396d94919 249 SUPERFAMILY SSF51161 66 212 1.52E-32 T 09-03-2017 IPR011004 Trimeric LpxA-like TK78_RS31345 cf673730ec99171ae26ba87396d94919 249 ProSitePatterns PS00101 Hexapeptide-repeat containing-transferases signature. 164 192 - T 09-03-2017 IPR018357 Hexapeptide transferase, conserved site GO:0016740 Reactome: R-HSA-446205 TK78_RS13100 d94e7ddaef44ab244394a4f3a44e0445 61 Hamap MF_01364_B 30S ribosomal protein S14 type Z [rpsZ]. 1 61 25.525 T 09-03-2017 IPR023053 Ribosomal protein S14, type Z TK78_RS13100 d94e7ddaef44ab244394a4f3a44e0445 61 Pfam PF00253 Ribosomal protein S14p/S29e 9 60 1.4E-24 T 09-03-2017 IPR001209 Ribosomal protein S14 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13100 d94e7ddaef44ab244394a4f3a44e0445 61 SUPERFAMILY SSF57716 4 61 1.43E-21 T 09-03-2017 TK78_RS13100 d94e7ddaef44ab244394a4f3a44e0445 61 Gene3D G3DSA:4.10.830.10 2 61 1.2E-27 T 09-03-2017 TK78_RS13100 d94e7ddaef44ab244394a4f3a44e0445 61 ProSitePatterns PS00527 Ribosomal protein S14 signature. 23 45 - T 09-03-2017 IPR018271 Ribosomal protein S14, conserved site GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS24375 c9a850787196ad7bff70d579ee7020e3 166 SUPERFAMILY SSF109604 10 141 2.33E-24 T 09-03-2017 TK78_RS24375 c9a850787196ad7bff70d579ee7020e3 166 Pfam PF13328 HD domain 14 88 8.4E-10 T 09-03-2017 IPR003607 HD/PDEase domain TK78_RS33240 6c488603303837c923739b917d32b7f0 398 SUPERFAMILY SSF48264 16 398 2.23E-89 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS33240 6c488603303837c923739b917d32b7f0 398 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 340 349 - T 09-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 TK78_RS33240 6c488603303837c923739b917d32b7f0 398 Gene3D G3DSA:1.10.630.10 9 398 3.5E-118 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS33240 6c488603303837c923739b917d32b7f0 398 PRINTS PR00359 B-class P450 signature 189 211 8.1E-48 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS33240 6c488603303837c923739b917d32b7f0 398 PRINTS PR00359 B-class P450 signature 338 347 8.1E-48 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS33240 6c488603303837c923739b917d32b7f0 398 PRINTS PR00359 B-class P450 signature 134 150 8.1E-48 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS33240 6c488603303837c923739b917d32b7f0 398 PRINTS PR00359 B-class P450 signature 289 316 8.1E-48 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS33240 6c488603303837c923739b917d32b7f0 398 PRINTS PR00359 B-class P450 signature 347 358 8.1E-48 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS33240 6c488603303837c923739b917d32b7f0 398 PRINTS PR00359 B-class P450 signature 151 166 8.1E-48 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS33240 6c488603303837c923739b917d32b7f0 398 PRINTS PR00359 B-class P450 signature 270 281 8.1E-48 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS33240 6c488603303837c923739b917d32b7f0 398 PRINTS PR00359 B-class P450 signature 87 98 8.1E-48 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS33240 6c488603303837c923739b917d32b7f0 398 PRINTS PR00359 B-class P450 signature 317 332 8.1E-48 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS33240 6c488603303837c923739b917d32b7f0 398 Pfam PF00067 Cytochrome P450 181 370 2.9E-26 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 ProSitePatterns PS00329 Heat shock hsp70 proteins family signature 2. 166 179 - T 09-03-2017 IPR018181 Heat shock protein 70, conserved site Reactome: R-HSA-3371453 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 PRINTS PR00301 70kDa heat shock protein signature 54 62 5.3E-74 T 09-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 PRINTS PR00301 70kDa heat shock protein signature 336 356 5.3E-74 T 09-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 PRINTS PR00301 70kDa heat shock protein signature 31 43 5.3E-74 T 09-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 PRINTS PR00301 70kDa heat shock protein signature 359 378 5.3E-74 T 09-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 PRINTS PR00301 70kDa heat shock protein signature 440 456 5.3E-74 T 09-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 PRINTS PR00301 70kDa heat shock protein signature 304 320 5.3E-74 T 09-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 PRINTS PR00301 70kDa heat shock protein signature 3 16 5.3E-74 T 09-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 PRINTS PR00301 70kDa heat shock protein signature 114 134 5.3E-74 T 09-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 PRINTS PR00301 70kDa heat shock protein signature 172 182 5.3E-74 T 09-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 Gene3D G3DSA:3.90.640.10 200 285 5.6E-31 T 09-03-2017 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 ProSitePatterns PS01036 Heat shock hsp70 proteins family signature 3. 307 321 - T 09-03-2017 IPR018181 Heat shock protein 70, conserved site Reactome: R-HSA-3371453 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 TIGRFAM TIGR02350 prok_dnaK: chaperone protein DnaK 4 574 1.0E-276 T 09-03-2017 IPR012725 Chaperone DnaK GO:0005524|GO:0006457|GO:0051082 Reactome: R-HSA-1268020|Reactome: R-HSA-3371453 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 Pfam PF00012 Hsp70 protein 4 574 4.2E-245 T 09-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 Hamap MF_00332 Chaperone protein DnaK [dnaK]. 1 608 35.965 T 09-03-2017 IPR012725 Chaperone DnaK GO:0005524|GO:0006457|GO:0051082 Reactome: R-HSA-1268020|Reactome: R-HSA-3371453 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 Gene3D G3DSA:1.20.1270.10 504 574 1.5E-27 T 09-03-2017 IPR029048 Heat shock protein 70kD, C-terminal domain Reactome: R-HSA-3371453 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 Gene3D G3DSA:3.30.420.40 4 38 8.1E-56 T 09-03-2017 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 Gene3D G3DSA:3.30.420.40 101 168 8.1E-56 T 09-03-2017 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 SUPERFAMILY SSF53067 4 160 9.39E-58 T 09-03-2017 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 SUPERFAMILY SSF100920 355 511 4.84E-59 T 09-03-2017 IPR029047 Heat shock protein 70kD, peptide-binding domain Reactome: R-HSA-3371453 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 SUPERFAMILY SSF53067 161 353 2.78E-65 T 09-03-2017 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 Gene3D G3DSA:3.30.30.30 39 100 5.0E-16 T 09-03-2017 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 SUPERFAMILY SSF100934 478 576 5.1E-15 T 09-03-2017 IPR029048 Heat shock protein 70kD, C-terminal domain Reactome: R-HSA-3371453 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 Gene3D G3DSA:2.60.34.10 361 503 1.7E-71 T 09-03-2017 IPR029047 Heat shock protein 70kD, peptide-binding domain Reactome: R-HSA-3371453 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 ProSitePatterns PS00297 Heat shock hsp70 proteins family signature 1. 7 14 - T 09-03-2017 IPR018181 Heat shock protein 70, conserved site Reactome: R-HSA-3371453 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 Gene3D G3DSA:3.30.420.40 289 331 6.4E-34 T 09-03-2017 TK78_RS16095 19fee771838e5c8e365c77c2021ea642 617 Gene3D G3DSA:3.30.420.40 169 199 6.4E-34 T 09-03-2017 TK78_RS16980 b75e302364b6ce1ad6234e827b26c39d 153 Pfam PF04314 Protein of unknown function (DUF461) 44 139 3.3E-30 T 09-03-2017 IPR007410 DR1885-like metal-binding protein TK78_RS16980 b75e302364b6ce1ad6234e827b26c39d 153 SUPERFAMILY SSF110087 29 147 5.49E-35 T 09-03-2017 IPR007410 DR1885-like metal-binding protein TK78_RS34675 fb7ac62ef433b33ee9900e278a1fc91a 326 Gene3D G3DSA:1.10.10.10 251 322 3.6E-11 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS34675 fb7ac62ef433b33ee9900e278a1fc91a 326 Pfam PF12840 Helix-turn-helix domain 252 308 1.0E-6 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS34675 fb7ac62ef433b33ee9900e278a1fc91a 326 SMART SM00418 251 326 1.6E-4 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS34675 fb7ac62ef433b33ee9900e278a1fc91a 326 SUPERFAMILY SSF46785 252 321 1.63E-11 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS07320 52243d4544461f6364a42907dd89ee53 219 ProSitePatterns PS00175 Phosphoglycerate mutase family phosphohistidine signature. 9 18 - T 09-03-2017 IPR001345 Phosphoglycerate/bisphosphoglycerate mutase, active site GO:0003824|GO:0008152 TK78_RS07320 52243d4544461f6364a42907dd89ee53 219 Gene3D G3DSA:3.40.50.1240 4 204 7.1E-45 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS07320 52243d4544461f6364a42907dd89ee53 219 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 7 190 3.1E-36 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS07320 52243d4544461f6364a42907dd89ee53 219 SUPERFAMILY SSF53254 6 200 4.71E-40 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS07320 52243d4544461f6364a42907dd89ee53 219 SMART SM00855 6 166 2.3E-17 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS10080 ab084a274e80829a58c9e743835aae5b 206 Gene3D G3DSA:1.10.3300.10 8 185 1.4E-46 T 09-03-2017 IPR023286 ABATE domain TK78_RS10080 ab084a274e80829a58c9e743835aae5b 206 Pfam PF11706 CGNR zinc finger 141 183 5.1E-15 T 09-03-2017 IPR021005 Zinc finger, CGNR TK78_RS10080 ab084a274e80829a58c9e743835aae5b 206 Pfam PF07336 Putative stress-induced transcription regulator 9 135 1.7E-16 T 09-03-2017 IPR010852 Putative stress-induced transcription regulator TK78_RS10080 ab084a274e80829a58c9e743835aae5b 206 SUPERFAMILY SSF160904 8 182 4.58E-39 T 09-03-2017 TK78_RS06655 45d265a865deb42145f06fa38469db1a 286 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C 26 53 3.0E-5 T 09-03-2017 IPR025966 Oligopeptide transport permease C-like, N-terminal domain TK78_RS06655 45d265a865deb42145f06fa38469db1a 286 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 102 284 1.2E-26 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS06655 45d265a865deb42145f06fa38469db1a 286 SUPERFAMILY SSF161098 79 266 2.22E-24 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS06655 45d265a865deb42145f06fa38469db1a 286 Gene3D G3DSA:1.10.3720.10 75 281 1.1E-24 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS10605 707ef503191bb7ba426018ee0a82a665 1239 Pfam PF00580 UvrD/REP helicase N-terminal domain 20 329 1.9E-47 T 09-03-2017 IPR014016 UvrD-like Helicase, ATP-binding domain GO:0005524 TK78_RS10605 707ef503191bb7ba426018ee0a82a665 1239 Pfam PF13361 UvrD-like helicase C-terminal domain 341 750 7.6E-27 T 09-03-2017 IPR014017 UvrD-like DNA helicase, C-terminal GO:0005524|GO:0016787 TK78_RS10605 707ef503191bb7ba426018ee0a82a665 1239 Gene3D G3DSA:3.40.50.300 654 689 9.7E-43 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10605 707ef503191bb7ba426018ee0a82a665 1239 Gene3D G3DSA:3.40.50.300 344 456 9.7E-43 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10605 707ef503191bb7ba426018ee0a82a665 1239 Gene3D G3DSA:3.40.50.300 728 778 9.7E-43 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10605 707ef503191bb7ba426018ee0a82a665 1239 SUPERFAMILY SSF52540 732 778 9.64E-114 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10605 707ef503191bb7ba426018ee0a82a665 1239 SUPERFAMILY SSF52540 539 693 9.64E-114 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10605 707ef503191bb7ba426018ee0a82a665 1239 SUPERFAMILY SSF52540 17 492 9.64E-114 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10605 707ef503191bb7ba426018ee0a82a665 1239 Pfam PF12705 PD-(D/E)XK nuclease superfamily 1045 1211 8.0E-12 T 09-03-2017 TK78_RS10605 707ef503191bb7ba426018ee0a82a665 1239 Gene3D G3DSA:3.40.50.300 196 332 9.8E-63 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10605 707ef503191bb7ba426018ee0a82a665 1239 Gene3D G3DSA:3.40.50.300 19 153 9.8E-63 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10605 707ef503191bb7ba426018ee0a82a665 1239 SUPERFAMILY SSF52980 1046 1202 1.93E-7 T 09-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 TK78_RS10605 707ef503191bb7ba426018ee0a82a665 1239 Gene3D G3DSA:1.10.486.10 457 632 9.9E-24 T 09-03-2017 TK78_RS23300 34e4d12fd62ee409c9904114938115f9 511 Pfam PF01565 FAD binding domain 25 162 1.1E-22 T 09-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 TK78_RS23300 34e4d12fd62ee409c9904114938115f9 511 Pfam PF08031 Berberine and berberine like 455 507 2.8E-20 T 09-03-2017 IPR012951 Berberine/berberine-like GO:0016491|GO:0050660|GO:0055114 TK78_RS23300 34e4d12fd62ee409c9904114938115f9 511 Gene3D G3DSA:3.30.465.10 84 197 4.0E-9 T 09-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 TK78_RS23300 34e4d12fd62ee409c9904114938115f9 511 SUPERFAMILY SSF56176 13 198 3.69E-40 T 09-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 TK78_RS23300 34e4d12fd62ee409c9904114938115f9 511 Gene3D G3DSA:3.30.43.10 15 83 2.5E-9 T 09-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 TK78_RS11480 5a2d7ddbe2fcee011f315d95acf08d54 228 Gene3D G3DSA:3.40.50.300 7 221 1.6E-67 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS11480 5a2d7ddbe2fcee011f315d95acf08d54 228 Pfam PF00005 ABC transporter 23 171 5.9E-32 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS11480 5a2d7ddbe2fcee011f315d95acf08d54 228 SUPERFAMILY SSF52540 7 224 1.36E-63 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS11480 5a2d7ddbe2fcee011f315d95acf08d54 228 SMART SM00382 32 220 3.7E-19 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS06745 225ee618bf2135db8818b6be15ab4801 371 PIRSF PIRSF000138 1 368 2.4E-127 T 09-03-2017 IPR012133 Alpha-hydroxy acid dehydrogenase, FMN-dependent GO:0010181|GO:0016491|GO:0055114 TK78_RS06745 225ee618bf2135db8818b6be15ab4801 371 Gene3D G3DSA:3.20.20.70 13 358 1.9E-128 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS06745 225ee618bf2135db8818b6be15ab4801 371 ProSitePatterns PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site. 262 268 - T 09-03-2017 IPR008259 FMN-dependent alpha-hydroxy acid dehydrogenase, active site GO:0016491|GO:0055114 TK78_RS06745 225ee618bf2135db8818b6be15ab4801 371 Pfam PF01070 FMN-dependent dehydrogenase 24 358 2.0E-122 T 09-03-2017 IPR000262 FMN-dependent dehydrogenase GO:0016491 TK78_RS06745 225ee618bf2135db8818b6be15ab4801 371 SUPERFAMILY SSF51395 12 357 5.49E-89 T 09-03-2017 TK78_RS02220 c8d14cb1355dff654f17e47fd00ebf17 272 Pfam PF04672 S-adenosyl methyltransferase 5 271 8.5E-100 T 09-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type TK78_RS02220 c8d14cb1355dff654f17e47fd00ebf17 272 Gene3D G3DSA:3.40.50.150 1 271 7.7E-108 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS02220 c8d14cb1355dff654f17e47fd00ebf17 272 SUPERFAMILY SSF53335 16 252 1.74E-45 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS02220 c8d14cb1355dff654f17e47fd00ebf17 272 PIRSF PIRSF017393 1 272 1.4E-96 T 09-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type TK78_RS03890 031caffa1b1f2c88acca1706a274ba3c 360 SUPERFAMILY SSF51658 75 352 1.07E-32 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS03890 031caffa1b1f2c88acca1706a274ba3c 360 Pfam PF01261 Xylose isomerase-like TIM barrel 92 307 5.9E-23 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS03890 031caffa1b1f2c88acca1706a274ba3c 360 Gene3D G3DSA:3.20.20.150 64 354 1.6E-58 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS26810 f3eeaaa5fc89927cee89ee2069a223ee 93 Gene3D G3DSA:3.30.70.920 3 78 1.6E-25 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS26810 f3eeaaa5fc89927cee89ee2069a223ee 93 SUPERFAMILY SSF54909 2 78 5.36E-19 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS26810 f3eeaaa5fc89927cee89ee2069a223ee 93 Pfam PF01037 Lrp/AsnC ligand binding domain 6 77 2.0E-16 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS14940 0e76a8be8bea5560232ce25e3e1e6bc6 192 SUPERFAMILY SSF48498 86 186 1.05E-17 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS14940 0e76a8be8bea5560232ce25e3e1e6bc6 192 Gene3D G3DSA:1.10.10.60 4 65 2.8E-19 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS14940 0e76a8be8bea5560232ce25e3e1e6bc6 192 Pfam PF13305 WHG domain 92 172 1.7E-13 T 09-03-2017 IPR025996 WHG domain TK78_RS14940 0e76a8be8bea5560232ce25e3e1e6bc6 192 Pfam PF00440 Bacterial regulatory proteins, tetR family 18 64 1.9E-13 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS14940 0e76a8be8bea5560232ce25e3e1e6bc6 192 SUPERFAMILY SSF46689 6 79 3.64E-14 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS14940 0e76a8be8bea5560232ce25e3e1e6bc6 192 Gene3D G3DSA:1.10.357.10 66 189 1.6E-24 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS14940 0e76a8be8bea5560232ce25e3e1e6bc6 192 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 18 31 3.6E-5 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS14940 0e76a8be8bea5560232ce25e3e1e6bc6 192 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 39 62 3.6E-5 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS14595 de8b320a7a26f21f69c6ce17b714e7da 194 Pfam PF05685 Putative restriction endonuclease 21 172 7.4E-24 T 09-03-2017 IPR008538 Domain of unknown function DUF820 TK78_RS14595 de8b320a7a26f21f69c6ce17b714e7da 194 SUPERFAMILY SSF52980 18 160 1.07E-15 T 09-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 TK78_RS14595 de8b320a7a26f21f69c6ce17b714e7da 194 Gene3D G3DSA:3.90.1570.10 19 157 1.2E-15 T 09-03-2017 IPR012296 Nuclease, putative, TT1808 TK78_RS33690 bbef51aef855a6ffd6bedfa274934cf9 566 Pfam PF00005 ABC transporter 350 496 3.0E-9 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS33690 bbef51aef855a6ffd6bedfa274934cf9 566 SUPERFAMILY SSF90123 16 323 5.1E-40 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS33690 bbef51aef855a6ffd6bedfa274934cf9 566 Pfam PF00664 ABC transporter transmembrane region 28 295 1.8E-15 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS33690 bbef51aef855a6ffd6bedfa274934cf9 566 ProSitePatterns PS00211 ABC transporters family signature. 469 483 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS33690 bbef51aef855a6ffd6bedfa274934cf9 566 SUPERFAMILY SSF52540 336 561 1.4E-39 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33690 bbef51aef855a6ffd6bedfa274934cf9 566 Gene3D G3DSA:3.40.50.300 348 558 1.3E-39 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33690 bbef51aef855a6ffd6bedfa274934cf9 566 Gene3D G3DSA:1.20.1560.10 17 328 1.3E-36 T 09-03-2017 TK78_RS22160 d023c04aed1847ae9fe36d4d021b88d1 315 Pfam PF01061 ABC-2 type transporter 72 273 2.5E-18 T 09-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 TK78_RS14730 4b4fc48133295c1e6b8e1bf2d43ca0ea 253 Pfam PF09844 Uncharacterized conserved protein (COG2071) 25 239 2.6E-71 T 09-03-2017 IPR018644 Protein of unknown function DUF2071 TK78_RS14730 4b4fc48133295c1e6b8e1bf2d43ca0ea 253 SUPERFAMILY SSF160104 14 198 1.54E-12 T 09-03-2017 TK78_RS13515 ea8d91eb57257430d0eebd52e3232e99 249 Pfam PF08894 Protein of unknown function (DUF1838) 21 244 1.4E-80 T 09-03-2017 IPR014990 Protein of unknown function DUF1838 TK78_RS08935 6dc625b559f258bfcea1f8cf4048d9da 406 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 235 301 2.7E-15 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS08935 6dc625b559f258bfcea1f8cf4048d9da 406 SMART SM00382 40 233 2.0E-16 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS08935 6dc625b559f258bfcea1f8cf4048d9da 406 Gene3D G3DSA:3.40.50.300 2 257 4.4E-79 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08935 6dc625b559f258bfcea1f8cf4048d9da 406 Pfam PF00005 ABC transporter 32 183 1.2E-30 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS08935 6dc625b559f258bfcea1f8cf4048d9da 406 ProSitePatterns PS00211 ABC transporters family signature. 156 170 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS08935 6dc625b559f258bfcea1f8cf4048d9da 406 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 234 323 2.1E-25 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS08935 6dc625b559f258bfcea1f8cf4048d9da 406 SUPERFAMILY SSF52540 3 255 1.66E-70 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS12475 79862d1e1906804e4439f82e14cf8cd4 293 Gene3D G3DSA:3.40.192.10 7 138 5.0E-41 T 09-03-2017 TK78_RS12475 79862d1e1906804e4439f82e14cf8cd4 293 SUPERFAMILY SSF51735 122 281 2.18E-38 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS12475 79862d1e1906804e4439f82e14cf8cd4 293 Pfam PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 123 282 2.0E-57 T 09-03-2017 IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|Reactome: R-HSA-196757 TK78_RS12475 79862d1e1906804e4439f82e14cf8cd4 293 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 109 130 5.7E-56 T 09-03-2017 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|Reactome: R-HSA-196757 TK78_RS12475 79862d1e1906804e4439f82e14cf8cd4 293 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 154 174 5.7E-56 T 09-03-2017 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|Reactome: R-HSA-196757 TK78_RS12475 79862d1e1906804e4439f82e14cf8cd4 293 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 205 234 5.7E-56 T 09-03-2017 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|Reactome: R-HSA-196757 TK78_RS12475 79862d1e1906804e4439f82e14cf8cd4 293 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 33 55 5.7E-56 T 09-03-2017 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|Reactome: R-HSA-196757 TK78_RS12475 79862d1e1906804e4439f82e14cf8cd4 293 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 256 274 5.7E-56 T 09-03-2017 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|Reactome: R-HSA-196757 TK78_RS12475 79862d1e1906804e4439f82e14cf8cd4 293 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 74 101 5.7E-56 T 09-03-2017 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|Reactome: R-HSA-196757 TK78_RS12475 79862d1e1906804e4439f82e14cf8cd4 293 SUPERFAMILY SSF53223 1 121 2.78E-35 T 09-03-2017 TK78_RS12475 79862d1e1906804e4439f82e14cf8cd4 293 Gene3D G3DSA:3.40.50.720 139 264 5.2E-42 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS12475 79862d1e1906804e4439f82e14cf8cd4 293 Hamap MF_01576 Bifunctional protein FolD [folD]. 3 283 34.692 T 09-03-2017 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|Reactome: R-HSA-196757 TK78_RS12475 79862d1e1906804e4439f82e14cf8cd4 293 Pfam PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 5 120 9.3E-33 T 09-03-2017 IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|Reactome: R-HSA-196757 TK78_RS31325 48865aa42a4254c2ed71ab71fe14d503 281 SUPERFAMILY SSF53335 25 235 2.34E-27 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS31325 48865aa42a4254c2ed71ab71fe14d503 281 Gene3D G3DSA:3.40.50.150 10 267 1.6E-65 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS24615 88f8737d1b93a4f48c28fc2b4ba7e582 62 SUPERFAMILY SSF144020 13 62 2.75E-7 T 09-03-2017 IPR024064 FdhE-like TK78_RS24615 88f8737d1b93a4f48c28fc2b4ba7e582 62 Gene3D G3DSA:3.90.1670.10 14 61 5.3E-6 T 09-03-2017 IPR024064 FdhE-like TK78_RS05575 0f58a07e1910f9cc4c8b8741a2321778 181 SUPERFAMILY SSF160379 1 179 6.54E-55 T 09-03-2017 TK78_RS05575 0f58a07e1910f9cc4c8b8741a2321778 181 PIRSF PIRSF008502 1 181 1.6E-50 T 09-03-2017 IPR012545 Protein of unknown function DUF1697 TK78_RS05575 0f58a07e1910f9cc4c8b8741a2321778 181 Gene3D G3DSA:3.30.70.1280 1 88 3.9E-29 T 09-03-2017 TK78_RS05575 0f58a07e1910f9cc4c8b8741a2321778 181 Pfam PF08002 Protein of unknown function (DUF1697) 1 137 4.1E-45 T 09-03-2017 IPR012545 Protein of unknown function DUF1697 TK78_RS34845 8abf6122b774d513a967ec7e49530532 1102 SUPERFAMILY SSF52540 225 352 7.36E-8 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS34845 8abf6122b774d513a967ec7e49530532 1102 Gene3D G3DSA:3.40.50.300 238 338 2.9E-4 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS00030 8abf6122b774d513a967ec7e49530532 1102 SUPERFAMILY SSF52540 225 352 7.36E-8 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS00030 8abf6122b774d513a967ec7e49530532 1102 Gene3D G3DSA:3.40.50.300 238 338 2.9E-4 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15320 fdee233e8f5d5539a4467848ec55a838 117 TIGRFAM TIGR00377 ant_ant_sig: anti-anti-sigma factor 16 111 5.5E-32 T 09-03-2017 IPR003658 Anti-sigma factor antagonist GO:0006355|GO:0045152 TK78_RS15320 fdee233e8f5d5539a4467848ec55a838 117 Gene3D G3DSA:3.30.750.24 15 115 3.0E-39 T 09-03-2017 IPR002645 STAS domain TK78_RS15320 fdee233e8f5d5539a4467848ec55a838 117 Pfam PF01740 STAS domain 14 112 4.0E-18 T 09-03-2017 IPR002645 STAS domain TK78_RS15320 fdee233e8f5d5539a4467848ec55a838 117 SUPERFAMILY SSF52091 15 114 6.28E-30 T 09-03-2017 IPR002645 STAS domain TK78_RS11885 d39bfcc40848f6870d25153aa90fb1ec 401 SUPERFAMILY SSF103473 12 393 2.62E-60 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS11885 d39bfcc40848f6870d25153aa90fb1ec 401 Pfam PF07690 Major Facilitator Superfamily 28 338 7.5E-33 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS11885 d39bfcc40848f6870d25153aa90fb1ec 401 Gene3D G3DSA:1.20.1250.20 21 205 8.9E-28 T 09-03-2017 TK78_RS11885 d39bfcc40848f6870d25153aa90fb1ec 401 Gene3D G3DSA:1.20.1250.20 217 392 1.4E-17 T 09-03-2017 TK78_RS13875 93845679ad0720460f7bd3f262a74dbe 145 Pfam PF12172 Rubredoxin-like zinc ribbon domain (DUF35_N) 25 60 2.6E-15 T 09-03-2017 IPR022002 Domain of unknown function DUF35, rubredoxin-like zinc ribbon domain, N-terminal TK78_RS13875 93845679ad0720460f7bd3f262a74dbe 145 Pfam PF01796 DUF35 OB-fold domain, acyl-CoA-associated 62 127 5.1E-20 T 09-03-2017 IPR002878 Domain of unknown function DUF35, OB-fold, C-terminal TK78_RS13875 93845679ad0720460f7bd3f262a74dbe 145 SUPERFAMILY SSF50249 14 131 6.85E-37 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS11060 135fc00065a45d747c400f9f327d81ea 397 SUPERFAMILY SSF53335 102 217 1.33E-28 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS11060 135fc00065a45d747c400f9f327d81ea 397 Gene3D G3DSA:3.40.50.150 33 268 8.5E-53 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS11060 135fc00065a45d747c400f9f327d81ea 397 Pfam PF01135 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) 74 218 5.6E-26 T 09-03-2017 TK78_RS06325 64e891dbfa034273b879781c8c59e5ff 420 Gene3D G3DSA:3.40.50.2000 212 386 3.1E-14 T 09-03-2017 TK78_RS06325 64e891dbfa034273b879781c8c59e5ff 420 Pfam PF13579 Glycosyl transferase 4-like domain 27 211 1.1E-18 T 09-03-2017 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 TK78_RS06325 64e891dbfa034273b879781c8c59e5ff 420 SUPERFAMILY SSF53756 14 409 8.64E-47 T 09-03-2017 TK78_RS06325 64e891dbfa034273b879781c8c59e5ff 420 Pfam PF13692 Glycosyl transferases group 1 235 375 1.7E-15 T 09-03-2017 TK78_RS13330 6360f040a8e5317a87c51d7826100c68 431 Gene3D G3DSA:2.30.40.10 21 92 1.5E-7 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS13330 6360f040a8e5317a87c51d7826100c68 431 Gene3D G3DSA:3.20.20.140 93 356 2.0E-58 T 09-03-2017 TK78_RS13330 6360f040a8e5317a87c51d7826100c68 431 SUPERFAMILY SSF51338 28 91 8.64E-6 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS13330 6360f040a8e5317a87c51d7826100c68 431 SUPERFAMILY SSF51556 78 365 1.18E-46 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS29695 6cb229f88410f61239eac7e4455bd29b 424 Pfam PF02638 Glycosyl hydrolase-like 10 37 352 1.0E-85 T 09-03-2017 IPR003790 Glycosyl hydrolase-like 10 TK78_RS29695 6cb229f88410f61239eac7e4455bd29b 424 SUPERFAMILY SSF51445 61 336 6.83E-19 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS32375 d12ceaae32dc905055795d4ece3f8727 207 Pfam PF07077 Protein of unknown function (DUF1345) 32 195 5.5E-47 T 09-03-2017 IPR009781 Protein of unknown function DUF1345 TK78_RS02410 3f3a1b94e73041d8859617041d18d0e2 444 SUPERFAMILY SSF51261 319 437 7.85E-45 T 09-03-2017 IPR011055 Duplicated hybrid motif TK78_RS02410 3f3a1b94e73041d8859617041d18d0e2 444 Gene3D G3DSA:1.10.530.10 22 123 5.4E-42 T 09-03-2017 TK78_RS02410 3f3a1b94e73041d8859617041d18d0e2 444 Pfam PF01476 LysM domain 179 225 1.5E-5 T 09-03-2017 IPR018392 LysM domain TK78_RS02410 3f3a1b94e73041d8859617041d18d0e2 444 SUPERFAMILY SSF53955 42 123 1.07E-31 T 09-03-2017 IPR023346 Lysozyme-like domain TK78_RS02410 3f3a1b94e73041d8859617041d18d0e2 444 Gene3D G3DSA:3.10.350.10 179 226 1.6E-7 T 09-03-2017 IPR018392 LysM domain TK78_RS02410 3f3a1b94e73041d8859617041d18d0e2 444 Gene3D G3DSA:2.70.70.10 291 438 6.8E-42 T 09-03-2017 TK78_RS02410 3f3a1b94e73041d8859617041d18d0e2 444 Pfam PF01551 Peptidase family M23 336 433 5.1E-30 T 09-03-2017 IPR016047 Peptidase M23 TK78_RS02410 3f3a1b94e73041d8859617041d18d0e2 444 Pfam PF06737 Transglycosylase-like domain 43 117 4.1E-34 T 09-03-2017 IPR010618 Transglycosylase-like TK78_RS02410 3f3a1b94e73041d8859617041d18d0e2 444 SMART SM00257 178 227 5.7E-4 T 09-03-2017 IPR018392 LysM domain TK78_RS16670 61d9344718101aae9e793fcd6eeb9ea7 294 SUPERFAMILY SSF51556 20 291 8.69E-55 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS16670 61d9344718101aae9e793fcd6eeb9ea7 294 Pfam PF04909 Amidohydrolase 21 290 8.8E-38 T 09-03-2017 IPR006680 Amidohydrolase-related GO:0016787 TK78_RS16670 61d9344718101aae9e793fcd6eeb9ea7 294 Gene3D G3DSA:3.20.20.140 18 292 1.4E-62 T 09-03-2017 TK78_RS15755 03b4bcdd5575340ade7c75b72da007fd 422 SUPERFAMILY SSF103473 12 407 1.83E-37 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS15755 03b4bcdd5575340ade7c75b72da007fd 422 Gene3D G3DSA:1.20.1250.20 223 406 4.0E-20 T 09-03-2017 TK78_RS15755 03b4bcdd5575340ade7c75b72da007fd 422 Gene3D G3DSA:1.20.1250.20 15 192 1.2E-8 T 09-03-2017 TK78_RS15755 03b4bcdd5575340ade7c75b72da007fd 422 Pfam PF07690 Major Facilitator Superfamily 232 406 8.4E-12 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS30620 b516d25303cd4a3cad36f21c814b56db 472 Gene3D G3DSA:1.25.10.10 377 455 5.0E-7 T 09-03-2017 IPR011989 Armadillo-like helical TK78_RS30620 b516d25303cd4a3cad36f21c814b56db 472 Gene3D G3DSA:1.25.10.10 186 343 5.0E-7 T 09-03-2017 IPR011989 Armadillo-like helical TK78_RS30620 b516d25303cd4a3cad36f21c814b56db 472 SUPERFAMILY SSF48371 236 432 6.99E-9 T 09-03-2017 IPR016024 Armadillo-type fold GO:0005488 TK78_RS28485 e04c981705066617defdf8b17d8c906f 214 SMART SM00421 150 207 5.2E-28 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS28485 e04c981705066617defdf8b17d8c906f 214 Gene3D G3DSA:3.40.50.2300 6 154 2.5E-43 T 09-03-2017 TK78_RS28485 e04c981705066617defdf8b17d8c906f 214 SMART SM00448 6 119 6.4E-35 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS28485 e04c981705066617defdf8b17d8c906f 214 Pfam PF00072 Response regulator receiver domain 8 119 2.3E-31 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS28485 e04c981705066617defdf8b17d8c906f 214 Gene3D G3DSA:1.10.10.10 155 212 3.4E-30 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS28485 e04c981705066617defdf8b17d8c906f 214 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 153 167 3.2E-16 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS28485 e04c981705066617defdf8b17d8c906f 214 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 167 183 3.2E-16 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS28485 e04c981705066617defdf8b17d8c906f 214 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 183 195 3.2E-16 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS28485 e04c981705066617defdf8b17d8c906f 214 ProSitePatterns PS00622 LuxR-type HTH domain signature. 167 194 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS28485 e04c981705066617defdf8b17d8c906f 214 Pfam PF00196 Bacterial regulatory proteins, luxR family 152 207 1.3E-21 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS28485 e04c981705066617defdf8b17d8c906f 214 SUPERFAMILY SSF46894 149 213 4.08E-23 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS28485 e04c981705066617defdf8b17d8c906f 214 SUPERFAMILY SSF52172 6 135 9.68E-37 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS19020 2822b9a83ac2f52ef6a08f7421f62e4e 304 Pfam PF10137 Predicted nucleotide-binding protein containing TIR-like domain 159 277 1.3E-29 T 09-03-2017 IPR019302 Nucleotide-binding protein, predicted, TIR-like domain TK78_RS29930 4beced829b214148363550cb5c720ded 272 Gene3D G3DSA:3.30.1330.30 7 105 9.4E-15 T 09-03-2017 IPR029064 50S ribosomal protein L30e-like TK78_RS29930 4beced829b214148363550cb5c720ded 272 SUPERFAMILY SSF75217 112 266 1.77E-37 T 09-03-2017 IPR029028 Alpha/beta knot methyltransferases TK78_RS29930 4beced829b214148363550cb5c720ded 272 Gene3D G3DSA:3.40.1280.10 117 266 7.5E-51 T 09-03-2017 IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal TK78_RS29930 4beced829b214148363550cb5c720ded 272 SUPERFAMILY SSF55315 6 106 8.24E-16 T 09-03-2017 IPR029064 50S ribosomal protein L30e-like TK78_RS29930 4beced829b214148363550cb5c720ded 272 Pfam PF00588 SpoU rRNA Methylase family 121 263 6.5E-34 T 09-03-2017 IPR001537 tRNA/rRNA methyltransferase, SpoU type GO:0003723|GO:0006396|GO:0008173 TK78_RS27900 8d5e7e6f7d7885d05eaa6dda035b42d1 168 Pfam PF03703 Bacterial PH domain 78 155 3.0E-18 T 09-03-2017 IPR005182 Domain of unknown function DUF304 TK78_RS17090 527e57d22cd1dbd7ab0b3308cb38b6dd 370 Gene3D G3DSA:3.40.50.2300 191 353 3.8E-34 T 09-03-2017 TK78_RS17090 527e57d22cd1dbd7ab0b3308cb38b6dd 370 ProSitePatterns PS00356 LacI-type HTH domain signature. 26 44 - T 09-03-2017 TK78_RS17090 527e57d22cd1dbd7ab0b3308cb38b6dd 370 Gene3D G3DSA:3.40.50.2300 80 190 1.7E-9 T 09-03-2017 TK78_RS17090 527e57d22cd1dbd7ab0b3308cb38b6dd 370 Pfam PF13377 Periplasmic binding protein-like domain 193 352 2.0E-29 T 09-03-2017 TK78_RS17090 527e57d22cd1dbd7ab0b3308cb38b6dd 370 SMART SM00354 23 93 3.8E-21 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS17090 527e57d22cd1dbd7ab0b3308cb38b6dd 370 SUPERFAMILY SSF47413 23 81 1.44E-16 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS17090 527e57d22cd1dbd7ab0b3308cb38b6dd 370 SUPERFAMILY SSF53822 102 357 4.93E-36 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS17090 527e57d22cd1dbd7ab0b3308cb38b6dd 370 Gene3D G3DSA:1.10.260.40 25 79 1.1E-23 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS17090 527e57d22cd1dbd7ab0b3308cb38b6dd 370 Pfam PF00356 Bacterial regulatory proteins, lacI family 26 70 2.5E-14 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS03780 f3f1ecb8568fac425690cf7082e9e357 269 Gene3D G3DSA:3.40.630.40 3 266 1.3E-61 T 09-03-2017 IPR002508 N-acetylmuramoyl-L-alanine amidase, catalytic domain GO:0008745|GO:0009253 TK78_RS03780 f3f1ecb8568fac425690cf7082e9e357 269 SUPERFAMILY SSF53187 7 265 9.73E-54 T 09-03-2017 TK78_RS03780 f3f1ecb8568fac425690cf7082e9e357 269 Pfam PF05013 N-formylglutamate amidohydrolase 17 241 2.1E-48 T 09-03-2017 IPR007709 N-formylglutamate amidohydrolase TK78_RS09685 f491da8c4f11c767bbe74e4cae6bded6 271 Pfam PF00213 ATP synthase delta (OSCP) subunit 108 268 4.5E-34 T 09-03-2017 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 Reactome: R-HSA-163210 TK78_RS09685 f491da8c4f11c767bbe74e4cae6bded6 271 Hamap MF_01416 ATP synthase subunit delta [atpD]. 95 271 15.188 T 09-03-2017 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 Reactome: R-HSA-163210 TK78_RS09685 f491da8c4f11c767bbe74e4cae6bded6 271 PRINTS PR00125 ATP synthase delta subunit signature 229 244 3.0E-7 T 09-03-2017 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 Reactome: R-HSA-163210 TK78_RS09685 f491da8c4f11c767bbe74e4cae6bded6 271 PRINTS PR00125 ATP synthase delta subunit signature 244 262 3.0E-7 T 09-03-2017 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 Reactome: R-HSA-163210 TK78_RS09685 f491da8c4f11c767bbe74e4cae6bded6 271 TIGRFAM TIGR01145 ATP_synt_delta: ATP synthase F1, delta subunit 111 267 2.7E-21 T 09-03-2017 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 Reactome: R-HSA-163210 TK78_RS09685 f491da8c4f11c767bbe74e4cae6bded6 271 Gene3D G3DSA:1.10.520.20 108 198 8.2E-6 T 09-03-2017 IPR026015 F1F0 ATP synthase OSCP/delta subunit, N-terminal domain Reactome: R-HSA-163210 TK78_RS09685 f491da8c4f11c767bbe74e4cae6bded6 271 SUPERFAMILY SSF47928 108 199 1.18E-5 T 09-03-2017 IPR026015 F1F0 ATP synthase OSCP/delta subunit, N-terminal domain Reactome: R-HSA-163210 TK78_RS02585 0aba62e94a7c3ac75c6a16d3de17bc53 264 Gene3D G3DSA:1.10.10.10 17 86 3.7E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS02585 0aba62e94a7c3ac75c6a16d3de17bc53 264 Pfam PF07729 FCD domain 106 226 2.4E-26 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS02585 0aba62e94a7c3ac75c6a16d3de17bc53 264 SMART SM00895 106 227 2.6E-24 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS02585 0aba62e94a7c3ac75c6a16d3de17bc53 264 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 56 72 3.8E-9 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS02585 0aba62e94a7c3ac75c6a16d3de17bc53 264 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 42 56 3.8E-9 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS02585 0aba62e94a7c3ac75c6a16d3de17bc53 264 Gene3D G3DSA:1.20.120.530 103 244 1.7E-31 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS02585 0aba62e94a7c3ac75c6a16d3de17bc53 264 SMART SM00345 23 82 6.5E-25 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS02585 0aba62e94a7c3ac75c6a16d3de17bc53 264 Pfam PF00392 Bacterial regulatory proteins, gntR family 19 82 1.5E-23 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS02585 0aba62e94a7c3ac75c6a16d3de17bc53 264 SUPERFAMILY SSF48008 103 231 5.75E-29 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS02585 0aba62e94a7c3ac75c6a16d3de17bc53 264 SUPERFAMILY SSF46785 16 86 5.69E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS31015 1138c1165e012b938dd75f046de4cdee 228 SUPERFAMILY SSF56784 16 223 2.67E-53 T 09-03-2017 IPR023214 HAD-like domain TK78_RS31015 1138c1165e012b938dd75f046de4cdee 228 TIGRFAM TIGR01549 HAD-SF-IA-v1: HAD hydrolase, family IA, variant 1 110 188 5.4E-9 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS31015 1138c1165e012b938dd75f046de4cdee 228 TIGRFAM TIGR01454 AHBA_synth_RP: AHBA synthesis associated protein 21 224 1.7E-105 T 09-03-2017 IPR006351 3-amino-5-hydroxybenzoic acid synthesis-related TK78_RS31015 1138c1165e012b938dd75f046de4cdee 228 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 98 190 1.8E-9 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS31015 1138c1165e012b938dd75f046de4cdee 228 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 18 29 1.0E-8 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS31015 1138c1165e012b938dd75f046de4cdee 228 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 138 154 1.0E-8 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS31015 1138c1165e012b938dd75f046de4cdee 228 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 107 120 1.0E-8 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS31015 1138c1165e012b938dd75f046de4cdee 228 Gene3D G3DSA:3.40.50.1000 98 223 5.7E-42 T 09-03-2017 IPR023214 HAD-like domain TK78_RS31015 1138c1165e012b938dd75f046de4cdee 228 Gene3D G3DSA:3.40.50.1000 11 32 5.7E-42 T 09-03-2017 IPR023214 HAD-like domain TK78_RS31015 1138c1165e012b938dd75f046de4cdee 228 Pfam PF13419 Haloacid dehalogenase-like hydrolase 21 193 3.8E-31 T 09-03-2017 IPR023214 HAD-like domain TK78_RS03505 df7bb5b7fb9feac064305672afcb0b91 293 Pfam PF02405 Permease MlaE 72 283 1.9E-66 T 09-03-2017 IPR030802 ABC transporter permease MalE GO:0006810|GO:0043190 TK78_RS26855 31f198f67e9f5e4519122cec762eb3c6 598 SUPERFAMILY SSF56801 17 288 1.31E-115 T 09-03-2017 TK78_RS26855 31f198f67e9f5e4519122cec762eb3c6 598 SUPERFAMILY SSF56801 337 596 1.31E-115 T 09-03-2017 TK78_RS26855 31f198f67e9f5e4519122cec762eb3c6 598 Pfam PF00501 AMP-binding enzyme 23 466 6.1E-102 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS26855 31f198f67e9f5e4519122cec762eb3c6 598 Gene3D G3DSA:3.30.300.30 464 543 2.3E-5 T 09-03-2017 TK78_RS26855 31f198f67e9f5e4519122cec762eb3c6 598 ProSitePatterns PS00455 Putative AMP-binding domain signature. 183 194 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS26855 31f198f67e9f5e4519122cec762eb3c6 598 Gene3D G3DSA:3.40.50.980 334 396 1.5E-27 T 09-03-2017 TK78_RS26855 31f198f67e9f5e4519122cec762eb3c6 598 Gene3D G3DSA:3.40.50.980 190 283 1.5E-27 T 09-03-2017 TK78_RS26855 31f198f67e9f5e4519122cec762eb3c6 598 Gene3D G3DSA:3.40.50.980 17 189 1.4E-36 T 09-03-2017 TK78_RS26855 31f198f67e9f5e4519122cec762eb3c6 598 Gene3D G3DSA:2.30.38.10 397 457 3.0E-19 T 09-03-2017 TK78_RS34145 e8a5d1b320f9648fdff4785571d21588 388 PIRSF PIRSF000429 1 377 1.2E-18 T 09-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 TK78_RS34145 e8a5d1b320f9648fdff4785571d21588 388 Gene3D G3DSA:3.40.47.10 14 118 6.4E-16 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS34145 e8a5d1b320f9648fdff4785571d21588 388 Gene3D G3DSA:3.40.47.10 196 222 6.4E-16 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS34145 e8a5d1b320f9648fdff4785571d21588 388 SUPERFAMILY SSF53901 5 122 8.18E-24 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS34145 e8a5d1b320f9648fdff4785571d21588 388 SUPERFAMILY SSF53901 200 377 8.18E-24 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS34145 e8a5d1b320f9648fdff4785571d21588 388 Gene3D G3DSA:3.40.47.10 274 368 2.2E-5 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS14355 a62beab41d4fe03d78b0695f47047d7a 213 Gene3D G3DSA:1.10.3630.10 2 208 5.4E-32 T 09-03-2017 TK78_RS14355 a62beab41d4fe03d78b0695f47047d7a 213 Pfam PF05719 Golgi phosphoprotein 3 (GPP34) 6 197 7.5E-40 T 09-03-2017 IPR008628 Golgi phosphoprotein 3 GO:0048193|GO:0070273 TK78_RS04530 f398788a508568251abc6d3267895326 320 Pfam PF00766 Electron transfer flavoprotein FAD-binding domain 196 278 5.0E-35 T 09-03-2017 IPR014731 Electron transfer flavoprotein, alpha subunit, C-terminal Reactome: R-HSA-611105 TK78_RS04530 f398788a508568251abc6d3267895326 320 SUPERFAMILY SSF52402 3 186 4.4E-32 T 09-03-2017 TK78_RS04530 f398788a508568251abc6d3267895326 320 SUPERFAMILY SSF52467 194 315 7.85E-46 T 09-03-2017 IPR029035 DHS-like NAD/FAD-binding domain TK78_RS04530 f398788a508568251abc6d3267895326 320 PIRSF PIRSF000089 1 320 1.6E-94 T 09-03-2017 IPR001308 Electron transfer flavoprotein alpha subunit/FixB GO:0009055|GO:0050660 Reactome: R-HSA-611105 TK78_RS04530 f398788a508568251abc6d3267895326 320 Gene3D G3DSA:3.40.50.620 3 184 2.9E-34 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS04530 f398788a508568251abc6d3267895326 320 ProSitePatterns PS00696 Electron transfer flavoprotein alpha-subunit signature. 259 285 - T 09-03-2017 IPR018206 Electron transfer flavoprotein subunit alpha, conserved site Reactome: R-HSA-611105 TK78_RS04530 f398788a508568251abc6d3267895326 320 Gene3D G3DSA:3.40.50.1220 190 316 3.7E-57 T 09-03-2017 IPR029035 DHS-like NAD/FAD-binding domain TK78_RS04530 f398788a508568251abc6d3267895326 320 Pfam PF01012 Electron transfer flavoprotein domain 4 172 7.3E-25 T 09-03-2017 IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal Reactome: R-HSA-611105 TK78_RS04530 f398788a508568251abc6d3267895326 320 SMART SM00893 4 183 5.4E-14 T 09-03-2017 IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal Reactome: R-HSA-611105 TK78_RS22520 f4715e22ba541a61b12cf48fdc8d3a74 215 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 33 206 7.1E-17 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS22520 f4715e22ba541a61b12cf48fdc8d3a74 215 Gene3D G3DSA:1.10.3720.10 9 197 1.3E-21 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS22520 f4715e22ba541a61b12cf48fdc8d3a74 215 SUPERFAMILY SSF161098 13 198 1.05E-29 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS14220 eb5002e52150e50c841710f3f9575067 532 SUPERFAMILY SSF52096 232 512 1.8E-76 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS14220 eb5002e52150e50c841710f3f9575067 532 Gene3D G3DSA:3.90.226.10 274 521 1.2E-78 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS14220 eb5002e52150e50c841710f3f9575067 532 Gene3D G3DSA:3.90.226.10 27 266 4.2E-63 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS14220 eb5002e52150e50c841710f3f9575067 532 SUPERFAMILY SSF52096 23 263 2.72E-63 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS14220 eb5002e52150e50c841710f3f9575067 532 Pfam PF01039 Carboxyl transferase domain 48 520 3.3E-135 T 09-03-2017 IPR000022 Carboxyl transferase KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TK78_RS20050 32e72ddce4917cc1a2708b271521693c 117 SUPERFAMILY SSF54909 1 99 2.22E-21 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS20050 32e72ddce4917cc1a2708b271521693c 117 Gene3D G3DSA:3.30.70.900 6 80 1.7E-5 T 09-03-2017 TK78_RS20050 32e72ddce4917cc1a2708b271521693c 117 Pfam PF07978 NIPSNAP 6 99 1.7E-21 T 09-03-2017 IPR012577 NIPSNAP TK78_RS19615 8864f13314800742e97d0f76509590cb 482 TIGRFAM TIGR00666 PBP4: D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase 263 459 3.3E-45 T 09-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 TK78_RS19615 8864f13314800742e97d0f76509590cb 482 Gene3D G3DSA:3.40.710.10 118 200 1.6E-9 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS19615 8864f13314800742e97d0f76509590cb 482 PRINTS PR00922 D-Ala-D-Ala carboxypeptidase 3 (S13) family signature 371 385 1.9E-23 T 09-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 TK78_RS19615 8864f13314800742e97d0f76509590cb 482 PRINTS PR00922 D-Ala-D-Ala carboxypeptidase 3 (S13) family signature 436 449 1.9E-23 T 09-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 TK78_RS19615 8864f13314800742e97d0f76509590cb 482 PRINTS PR00922 D-Ala-D-Ala carboxypeptidase 3 (S13) family signature 299 321 1.9E-23 T 09-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 TK78_RS19615 8864f13314800742e97d0f76509590cb 482 PRINTS PR00922 D-Ala-D-Ala carboxypeptidase 3 (S13) family signature 356 370 1.9E-23 T 09-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 TK78_RS19615 8864f13314800742e97d0f76509590cb 482 PRINTS PR00922 D-Ala-D-Ala carboxypeptidase 3 (S13) family signature 144 163 1.9E-23 T 09-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 TK78_RS19615 8864f13314800742e97d0f76509590cb 482 Gene3D G3DSA:3.40.710.10 258 479 1.5E-61 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS19615 8864f13314800742e97d0f76509590cb 482 Pfam PF02113 D-Ala-D-Ala carboxypeptidase 3 (S13) family 107 253 1.1E-23 T 09-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 TK78_RS19615 8864f13314800742e97d0f76509590cb 482 Pfam PF02113 D-Ala-D-Ala carboxypeptidase 3 (S13) family 261 473 4.5E-54 T 09-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 TK78_RS19615 8864f13314800742e97d0f76509590cb 482 SUPERFAMILY SSF56601 110 478 8.72E-62 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS30505 4f068af93d9d7dd4e3f2340d5f119e1c 634 Gene3D G3DSA:3.40.50.300 348 523 4.4E-22 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS30505 4f068af93d9d7dd4e3f2340d5f119e1c 634 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 390 523 4.1E-14 T 09-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 TK78_RS30505 4f068af93d9d7dd4e3f2340d5f119e1c 634 PRINTS PR00819 CbxX/CfqX superfamily signature 473 485 3.0E-50 T 09-03-2017 IPR000641 CbxX/CfqX GO:0005524 TK78_RS30505 4f068af93d9d7dd4e3f2340d5f119e1c 634 PRINTS PR00819 CbxX/CfqX superfamily signature 494 511 3.0E-50 T 09-03-2017 IPR000641 CbxX/CfqX GO:0005524 TK78_RS30505 4f068af93d9d7dd4e3f2340d5f119e1c 634 PRINTS PR00819 CbxX/CfqX superfamily signature 388 403 3.0E-50 T 09-03-2017 IPR000641 CbxX/CfqX GO:0005524 TK78_RS30505 4f068af93d9d7dd4e3f2340d5f119e1c 634 PRINTS PR00819 CbxX/CfqX superfamily signature 440 459 3.0E-50 T 09-03-2017 IPR000641 CbxX/CfqX GO:0005524 TK78_RS30505 4f068af93d9d7dd4e3f2340d5f119e1c 634 PRINTS PR00819 CbxX/CfqX superfamily signature 571 583 3.0E-50 T 09-03-2017 IPR000641 CbxX/CfqX GO:0005524 TK78_RS30505 4f068af93d9d7dd4e3f2340d5f119e1c 634 PRINTS PR00819 CbxX/CfqX superfamily signature 511 530 3.0E-50 T 09-03-2017 IPR000641 CbxX/CfqX GO:0005524 TK78_RS30505 4f068af93d9d7dd4e3f2340d5f119e1c 634 PRINTS PR00819 CbxX/CfqX superfamily signature 348 362 3.0E-50 T 09-03-2017 IPR000641 CbxX/CfqX GO:0005524 TK78_RS30505 4f068af93d9d7dd4e3f2340d5f119e1c 634 PRINTS PR00819 CbxX/CfqX superfamily signature 426 440 3.0E-50 T 09-03-2017 IPR000641 CbxX/CfqX GO:0005524 TK78_RS30505 4f068af93d9d7dd4e3f2340d5f119e1c 634 SMART SM00382 385 526 4.3E-9 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS30505 4f068af93d9d7dd4e3f2340d5f119e1c 634 SUPERFAMILY SSF48452 158 251 6.56E-8 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS30505 4f068af93d9d7dd4e3f2340d5f119e1c 634 SUPERFAMILY SSF48452 13 46 6.56E-8 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS30505 4f068af93d9d7dd4e3f2340d5f119e1c 634 Gene3D G3DSA:1.25.40.10 176 253 2.1E-9 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS30505 4f068af93d9d7dd4e3f2340d5f119e1c 634 Gene3D G3DSA:1.25.40.10 18 52 2.1E-9 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS30505 4f068af93d9d7dd4e3f2340d5f119e1c 634 SUPERFAMILY SSF52540 349 608 1.19E-31 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33890 82e3d205f3b546ba101dc166c038812c 334 TIGRFAM TIGR00750 lao: LAO/AO transport system ATPase 17 322 1.2E-113 T 09-03-2017 IPR005129 SIMIBI class G3E GTPase, ArgK/MeaB GO:0003924|GO:0005525 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 TK78_RS33890 82e3d205f3b546ba101dc166c038812c 334 Gene3D G3DSA:3.40.50.300 56 258 1.2E-53 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33890 82e3d205f3b546ba101dc166c038812c 334 SUPERFAMILY SSF52540 5 325 6.14E-93 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33890 82e3d205f3b546ba101dc166c038812c 334 Gene3D G3DSA:1.10.287.130 264 312 2.5E-4 T 09-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TK78_RS33890 82e3d205f3b546ba101dc166c038812c 334 Pfam PF03308 ArgK protein 23 292 1.9E-111 T 09-03-2017 TK78_RS33890 82e3d205f3b546ba101dc166c038812c 334 Gene3D G3DSA:1.20.5.170 4 55 7.3E-22 T 09-03-2017 TK78_RS24890 5d934a2ea2b85ab6c5327ab9921bb1e0 144 Gene3D G3DSA:1.10.10.10 17 84 8.3E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS24890 5d934a2ea2b85ab6c5327ab9921bb1e0 144 Pfam PF01475 Ferric uptake regulator family 17 132 3.3E-30 T 09-03-2017 IPR002481 Ferric-uptake regulator GO:0003700|GO:0006355 TK78_RS24890 5d934a2ea2b85ab6c5327ab9921bb1e0 144 SUPERFAMILY SSF46785 17 137 9.8E-33 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS31905 c7c30da2d416ffc95013598e02bc1621 1323 TIGRFAM TIGR03924 T7SS_EccC_a: type VII secretion protein EccCa 9 700 4.6E-247 T 09-03-2017 IPR023836 EccCa-like, Actinobacteria TK78_RS31905 c7c30da2d416ffc95013598e02bc1621 1323 Gene3D G3DSA:3.40.50.300 453 670 9.8E-18 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31905 c7c30da2d416ffc95013598e02bc1621 1323 Gene3D G3DSA:3.40.50.300 820 1010 2.5E-12 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31905 c7c30da2d416ffc95013598e02bc1621 1323 Gene3D G3DSA:3.40.50.300 1094 1181 2.5E-7 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31905 c7c30da2d416ffc95013598e02bc1621 1323 SUPERFAMILY SSF52540 442 667 1.38E-25 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31905 c7c30da2d416ffc95013598e02bc1621 1323 SUPERFAMILY SSF52540 764 1015 5.76E-25 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31905 c7c30da2d416ffc95013598e02bc1621 1323 SMART SM00382 476 656 0.019 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS31905 c7c30da2d416ffc95013598e02bc1621 1323 SMART SM00382 1116 1283 4.8 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS31905 c7c30da2d416ffc95013598e02bc1621 1323 SMART SM00382 828 1007 0.34 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS31905 c7c30da2d416ffc95013598e02bc1621 1323 SUPERFAMILY SSF52540 1074 1255 1.03E-9 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31905 c7c30da2d416ffc95013598e02bc1621 1323 Pfam PF01580 FtsK/SpoIIIE family 1096 1192 3.3E-6 T 09-03-2017 IPR002543 FtsK domain GO:0000166|GO:0003677|GO:0005524 TK78_RS31905 c7c30da2d416ffc95013598e02bc1621 1323 Pfam PF01580 FtsK/SpoIIIE family 805 1039 1.8E-49 T 09-03-2017 IPR002543 FtsK domain GO:0000166|GO:0003677|GO:0005524 TK78_RS31905 c7c30da2d416ffc95013598e02bc1621 1323 Pfam PF01580 FtsK/SpoIIIE family 452 569 4.8E-24 T 09-03-2017 IPR002543 FtsK domain GO:0000166|GO:0003677|GO:0005524 TK78_RS31905 c7c30da2d416ffc95013598e02bc1621 1323 TIGRFAM TIGR03925 T7SS_EccC_b: type VII secretion protein EccCb 748 1320 7.5E-218 T 09-03-2017 IPR023837 EccCb-like, Actinobacteria TK78_RS34535 fec03744f1f68ddaa093c31d6d0e93c5 246 SUPERFAMILY SSF53335 26 217 2.39E-34 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS34535 fec03744f1f68ddaa093c31d6d0e93c5 246 Pfam PF13649 Methyltransferase domain 42 138 2.1E-18 T 09-03-2017 TK78_RS34535 fec03744f1f68ddaa093c31d6d0e93c5 246 Gene3D G3DSA:3.40.50.150 4 213 4.8E-31 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS08040 fb8a67471abadcc16d78147d2a359026 222 SUPERFAMILY SSF52172 3 134 1.57E-30 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS08040 fb8a67471abadcc16d78147d2a359026 222 Gene3D G3DSA:3.40.50.2300 3 124 1.6E-33 T 09-03-2017 TK78_RS08040 fb8a67471abadcc16d78147d2a359026 222 SMART SM00448 3 117 2.4E-28 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS08040 fb8a67471abadcc16d78147d2a359026 222 SUPERFAMILY SSF46894 142 215 3.74E-22 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS08040 fb8a67471abadcc16d78147d2a359026 222 Pfam PF00072 Response regulator receiver domain 5 117 1.1E-23 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS08040 fb8a67471abadcc16d78147d2a359026 222 Gene3D G3DSA:1.10.10.10 125 215 6.3E-31 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS08040 fb8a67471abadcc16d78147d2a359026 222 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 185 197 3.6E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS08040 fb8a67471abadcc16d78147d2a359026 222 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 169 185 3.6E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS08040 fb8a67471abadcc16d78147d2a359026 222 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 155 169 3.6E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS08040 fb8a67471abadcc16d78147d2a359026 222 SMART SM00421 152 209 5.0E-24 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS08040 fb8a67471abadcc16d78147d2a359026 222 Pfam PF00196 Bacterial regulatory proteins, luxR family 155 209 1.2E-17 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS08040 fb8a67471abadcc16d78147d2a359026 222 ProSitePatterns PS00622 LuxR-type HTH domain signature. 169 196 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS22330 32060cbe2ba0ab28953c2922c3d4847d 220 Pfam PF07336 Putative stress-induced transcription regulator 7 138 5.6E-25 T 09-03-2017 IPR010852 Putative stress-induced transcription regulator TK78_RS22330 32060cbe2ba0ab28953c2922c3d4847d 220 Pfam PF11706 CGNR zinc finger 144 185 8.7E-16 T 09-03-2017 IPR021005 Zinc finger, CGNR TK78_RS22330 32060cbe2ba0ab28953c2922c3d4847d 220 SUPERFAMILY SSF160904 2 185 2.35E-41 T 09-03-2017 TK78_RS22330 32060cbe2ba0ab28953c2922c3d4847d 220 Gene3D G3DSA:1.10.3300.10 2 186 4.6E-46 T 09-03-2017 IPR023286 ABATE domain TK78_RS11610 25be35ec28d84e17ab4e1503c4fcd75c 440 SMART SM00387 329 428 1.1E-5 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS11610 25be35ec28d84e17ab4e1503c4fcd75c 440 Gene3D G3DSA:3.30.565.10 310 426 2.0E-7 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS11610 25be35ec28d84e17ab4e1503c4fcd75c 440 Pfam PF07730 Histidine kinase 218 284 2.7E-12 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS11610 25be35ec28d84e17ab4e1503c4fcd75c 440 SUPERFAMILY SSF55874 322 426 4.58E-13 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS33825 e8748bd8eb54de93b9758ae5c3d9808f 79 Pfam PF00550 Phosphopantetheine attachment site 9 72 6.5E-14 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33825 e8748bd8eb54de93b9758ae5c3d9808f 79 SUPERFAMILY SSF47336 7 75 1.83E-13 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33825 e8748bd8eb54de93b9758ae5c3d9808f 79 SMART SM00823 Phosphopantetheine attachment site 8 66 0.006 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS33825 e8748bd8eb54de93b9758ae5c3d9808f 79 Gene3D G3DSA:1.10.1200.10 7 75 4.4E-12 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS30400 8d87fa9478732337a73c21d1896d9576 485 Gene3D G3DSA:3.40.309.10 268 450 1.0E-62 T 09-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 TK78_RS30400 8d87fa9478732337a73c21d1896d9576 485 Gene3D G3DSA:3.40.605.10 10 267 1.8E-81 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS30400 8d87fa9478732337a73c21d1896d9576 485 SUPERFAMILY SSF53720 6 478 1.03E-152 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS30400 8d87fa9478732337a73c21d1896d9576 485 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 252 259 - T 09-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 TK78_RS30400 8d87fa9478732337a73c21d1896d9576 485 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 280 291 - T 09-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 TK78_RS30400 8d87fa9478732337a73c21d1896d9576 485 Pfam PF00171 Aldehyde dehydrogenase family 24 474 5.3E-157 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS16245 c24cb6710c6df8b690bc215a06d78d97 256 Pfam PF01522 Polysaccharide deacetylase 66 188 3.3E-27 T 09-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 TK78_RS16245 c24cb6710c6df8b690bc215a06d78d97 256 SUPERFAMILY SSF88713 67 251 3.21E-51 T 09-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 TK78_RS16245 c24cb6710c6df8b690bc215a06d78d97 256 Gene3D G3DSA:3.20.20.370 62 251 6.1E-53 T 09-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 TK78_RS19630 0855ae30cfed72c14ac9078d76810f5a 179 TIGRFAM TIGR01203 HGPRTase: hypoxanthine phosphoribosyltransferase 8 172 1.5E-64 T 09-03-2017 IPR005904 Hypoxanthine phosphoribosyl transferase GO:0004422|GO:0005737|GO:0006166 KEGG: 00230+2.4.2.8|KEGG: 00983+2.4.2.8|MetaCyc: PWY-6599|MetaCyc: PWY-6609|MetaCyc: PWY-6610|MetaCyc: PWY-6620 TK78_RS19630 0855ae30cfed72c14ac9078d76810f5a 179 Gene3D G3DSA:3.40.50.2020 3 177 1.4E-79 T 09-03-2017 IPR029057 Phosphoribosyltransferase-like TK78_RS19630 0855ae30cfed72c14ac9078d76810f5a 179 SUPERFAMILY SSF53271 5 177 1.84E-54 T 09-03-2017 IPR029057 Phosphoribosyltransferase-like TK78_RS19630 0855ae30cfed72c14ac9078d76810f5a 179 Pfam PF00156 Phosphoribosyl transferase domain 12 159 1.6E-24 T 09-03-2017 IPR000836 Phosphoribosyltransferase domain GO:0009116 TK78_RS27175 a115915e8aa9dc21c52b36443f997135 384 Gene3D G3DSA:2.30.30.60 195 243 8.7E-11 T 09-03-2017 TK78_RS27175 a115915e8aa9dc21c52b36443f997135 384 Pfam PF00924 Mechanosensitive ion channel 137 328 1.1E-27 T 09-03-2017 IPR006685 Mechanosensitive ion channel MscS GO:0016020|GO:0055085 TK78_RS27175 a115915e8aa9dc21c52b36443f997135 384 SUPERFAMILY SSF50182 179 244 5.89E-15 T 09-03-2017 IPR010920 LSM domain TK78_RS16640 49e4a5e2ca3e88ea3a9bc86d16382f16 294 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 53 282 1.0E-19 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS16640 49e4a5e2ca3e88ea3a9bc86d16382f16 294 Gene3D G3DSA:3.60.10.10 50 227 1.3E-9 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS16640 49e4a5e2ca3e88ea3a9bc86d16382f16 294 SUPERFAMILY SSF56219 47 292 8.51E-37 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS27010 35caa7ed7bfabad4175fad5c2a7ff98a 203 Pfam PF00440 Bacterial regulatory proteins, tetR family 17 62 7.3E-20 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS27010 35caa7ed7bfabad4175fad5c2a7ff98a 203 Gene3D G3DSA:1.10.10.60 7 59 1.5E-23 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS27010 35caa7ed7bfabad4175fad5c2a7ff98a 203 SUPERFAMILY SSF48498 89 192 2.81E-16 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS27010 35caa7ed7bfabad4175fad5c2a7ff98a 203 SUPERFAMILY SSF46689 6 80 1.03E-21 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS27010 35caa7ed7bfabad4175fad5c2a7ff98a 203 Gene3D G3DSA:1.10.357.10 60 196 3.5E-30 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS27010 35caa7ed7bfabad4175fad5c2a7ff98a 203 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 16 29 4.0E-11 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS27010 35caa7ed7bfabad4175fad5c2a7ff98a 203 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 37 60 4.0E-11 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS15690 a1d4e405c61a3fa5c11e0c336e87156d 170 SUPERFAMILY SSF54427 16 166 1.28E-22 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS15690 a1d4e405c61a3fa5c11e0c336e87156d 170 TIGRFAM TIGR02246 TIGR02246: conserved hypothetical protein 18 105 1.5E-12 T 09-03-2017 IPR011944 Steroid delta5-4-isomerase KEGG: 00140+5.3.3.1|KEGG: 00984+5.3.3.1|MetaCyc: PWY-2582|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-6948|MetaCyc: PWY-699|MetaCyc: PWY-7299 TK78_RS15690 a1d4e405c61a3fa5c11e0c336e87156d 170 Pfam PF14534 Domain of unknown function (DUF4440) 22 153 3.2E-6 T 09-03-2017 IPR027843 Domain of unknown function DUF4440 TK78_RS15690 a1d4e405c61a3fa5c11e0c336e87156d 170 Gene3D G3DSA:3.10.450.50 8 167 2.8E-42 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS08565 a3b1e15e37c0201d2b8ee1e5833e1a18 322 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 6 297 2.1E-18 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS08565 a3b1e15e37c0201d2b8ee1e5833e1a18 322 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 109 117 3.1E-14 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS08565 a3b1e15e37c0201d2b8ee1e5833e1a18 322 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 7 29 3.1E-14 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS08565 a3b1e15e37c0201d2b8ee1e5833e1a18 322 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 272 290 3.1E-14 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS08565 a3b1e15e37c0201d2b8ee1e5833e1a18 322 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 146 170 3.1E-14 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS08565 a3b1e15e37c0201d2b8ee1e5833e1a18 322 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 131 143 3.1E-14 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS08565 a3b1e15e37c0201d2b8ee1e5833e1a18 322 SUPERFAMILY SSF51905 1 313 1.35E-35 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS08565 a3b1e15e37c0201d2b8ee1e5833e1a18 322 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 108 126 1.2E-15 T 09-03-2017 TK78_RS08565 a3b1e15e37c0201d2b8ee1e5833e1a18 322 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 150 168 1.2E-15 T 09-03-2017 TK78_RS08565 a3b1e15e37c0201d2b8ee1e5833e1a18 322 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 262 284 1.2E-15 T 09-03-2017 TK78_RS08565 a3b1e15e37c0201d2b8ee1e5833e1a18 322 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 8 27 1.2E-15 T 09-03-2017 TK78_RS08565 a3b1e15e37c0201d2b8ee1e5833e1a18 322 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 239 255 1.2E-15 T 09-03-2017 TK78_RS08565 a3b1e15e37c0201d2b8ee1e5833e1a18 322 Gene3D G3DSA:3.50.50.60 5 133 5.0E-26 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS08565 a3b1e15e37c0201d2b8ee1e5833e1a18 322 Gene3D G3DSA:3.50.50.60 134 233 4.3E-37 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS21000 5370a9fbb0c303927d984753946afbd4 533 SUPERFAMILY SSF51905 279 479 3.88E-20 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS21000 5370a9fbb0c303927d984753946afbd4 533 Pfam PF13738 Pyridine nucleotide-disulphide oxidoreductase 11 209 3.9E-17 T 09-03-2017 TK78_RS21000 5370a9fbb0c303927d984753946afbd4 533 SUPERFAMILY SSF51905 5 233 1.18E-60 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS21000 5370a9fbb0c303927d984753946afbd4 533 Gene3D G3DSA:3.50.50.60 318 486 1.6E-19 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS21000 5370a9fbb0c303927d984753946afbd4 533 Gene3D G3DSA:3.50.50.60 3 216 2.9E-67 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS21000 5370a9fbb0c303927d984753946afbd4 533 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 8 30 8.0E-5 T 09-03-2017 TK78_RS21000 5370a9fbb0c303927d984753946afbd4 533 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 174 199 8.0E-5 T 09-03-2017 TK78_RS01485 760cb2999ae49d7ee0d463c7e6aa7e88 224 Gene3D G3DSA:3.40.50.300 1 211 6.5E-55 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01485 760cb2999ae49d7ee0d463c7e6aa7e88 224 SMART SM00382 27 208 3.5E-12 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS01485 760cb2999ae49d7ee0d463c7e6aa7e88 224 Pfam PF00005 ABC transporter 19 168 1.1E-28 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS01485 760cb2999ae49d7ee0d463c7e6aa7e88 224 SUPERFAMILY SSF52540 2 212 2.66E-47 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18515 e8965155a47757488ad1a56df2f02934 221 Gene3D G3DSA:1.10.10.10 123 219 3.7E-31 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS18515 e8965155a47757488ad1a56df2f02934 221 Pfam PF00196 Bacterial regulatory proteins, luxR family 157 212 1.9E-17 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS18515 e8965155a47757488ad1a56df2f02934 221 ProSitePatterns PS00622 LuxR-type HTH domain signature. 172 199 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS18515 e8965155a47757488ad1a56df2f02934 221 SMART SM00448 2 115 5.1E-33 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS18515 e8965155a47757488ad1a56df2f02934 221 Pfam PF00072 Response regulator receiver domain 4 115 3.9E-28 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS18515 e8965155a47757488ad1a56df2f02934 221 SUPERFAMILY SSF52172 3 133 7.68E-36 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS18515 e8965155a47757488ad1a56df2f02934 221 SMART SM00421 155 212 1.5E-24 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS18515 e8965155a47757488ad1a56df2f02934 221 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 172 188 2.8E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS18515 e8965155a47757488ad1a56df2f02934 221 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 188 200 2.8E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS18515 e8965155a47757488ad1a56df2f02934 221 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 158 172 2.8E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS18515 e8965155a47757488ad1a56df2f02934 221 Gene3D G3DSA:3.40.50.2300 3 122 8.1E-39 T 09-03-2017 TK78_RS18515 e8965155a47757488ad1a56df2f02934 221 SUPERFAMILY SSF46894 140 218 8.84E-22 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS32860 551faf56c52bf1808fa8c1c7801805b4 146 SUPERFAMILY SSF55961 4 141 8.73E-15 T 09-03-2017 TK78_RS32860 551faf56c52bf1808fa8c1c7801805b4 146 Gene3D G3DSA:3.30.530.20 7 141 2.0E-11 T 09-03-2017 IPR023393 START-like domain TK78_RS22525 c7aea9b1b4fcec9f306931b00f4f5bf7 157 SUPERFAMILY SSF54909 63 148 1.09E-16 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS22525 c7aea9b1b4fcec9f306931b00f4f5bf7 157 Gene3D G3DSA:1.10.10.10 2 53 9.5E-13 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS22525 c7aea9b1b4fcec9f306931b00f4f5bf7 157 Gene3D G3DSA:3.30.70.920 56 140 1.0E-17 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS22525 c7aea9b1b4fcec9f306931b00f4f5bf7 157 Pfam PF13412 Winged helix-turn-helix DNA-binding 4 50 1.6E-8 T 09-03-2017 TK78_RS22525 c7aea9b1b4fcec9f306931b00f4f5bf7 157 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 30 49 3.1E-9 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS22525 c7aea9b1b4fcec9f306931b00f4f5bf7 157 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 3 19 3.1E-9 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS22525 c7aea9b1b4fcec9f306931b00f4f5bf7 157 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 19 30 3.1E-9 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS22525 c7aea9b1b4fcec9f306931b00f4f5bf7 157 SMART SM00344 3 109 6.4E-25 T 09-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 TK78_RS22525 c7aea9b1b4fcec9f306931b00f4f5bf7 157 Pfam PF01037 Lrp/AsnC ligand binding domain 72 138 8.6E-13 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS22525 c7aea9b1b4fcec9f306931b00f4f5bf7 157 SUPERFAMILY SSF46785 2 63 2.02E-10 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS21965 85cc1538e5d85fb254c86d4f700c147d 166 SUPERFAMILY SSF51182 16 149 1.97E-32 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS21965 85cc1538e5d85fb254c86d4f700c147d 166 Pfam PF05995 Cysteine dioxygenase type I 17 149 1.0E-21 T 09-03-2017 IPR010300 Cysteine dioxygenase type I GO:0005506|GO:0016702|GO:0055114 KEGG: 00270+1.13.11.20|KEGG: 00430+1.13.11.20|MetaCyc: PWY-5331|Reactome: R-HSA-1614558 TK78_RS21965 85cc1538e5d85fb254c86d4f700c147d 166 Gene3D G3DSA:2.60.120.10 46 149 3.0E-18 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS09025 951097805b21e5ae9fc9e65b15f2003a 334 Gene3D G3DSA:3.40.47.10 208 326 6.4E-19 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS09025 951097805b21e5ae9fc9e65b15f2003a 334 SUPERFAMILY SSF53901 46 328 2.64E-20 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS09025 951097805b21e5ae9fc9e65b15f2003a 334 Gene3D G3DSA:3.40.47.10 13 179 1.3E-4 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS09025 951097805b21e5ae9fc9e65b15f2003a 334 Pfam PF08541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal 239 326 3.0E-16 T 09-03-2017 IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, C-terminal KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 TK78_RS00930 b9494160e17813502fab58a8b1b10142 376 Gene3D G3DSA:1.10.12.10 268 315 3.6E-6 T 09-03-2017 IPR014748 Crontonase, C-terminal TK78_RS00930 b9494160e17813502fab58a8b1b10142 376 Gene3D G3DSA:3.90.226.10 3 197 1.4E-53 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS00930 b9494160e17813502fab58a8b1b10142 376 Pfam PF16113 Enoyl-CoA hydratase/isomerase 16 343 2.2E-121 T 09-03-2017 IPR032259 Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type GO:0003860 Reactome: R-HSA-70895 TK78_RS00930 b9494160e17813502fab58a8b1b10142 376 SUPERFAMILY SSF52096 252 329 6.45E-66 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS00930 b9494160e17813502fab58a8b1b10142 376 SUPERFAMILY SSF52096 4 188 6.45E-66 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS06210 fd6a2271ead66eb0a7a7fa185b77f960 274 ProSitePatterns PS00211 ABC transporters family signature. 165 179 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS06210 fd6a2271ead66eb0a7a7fa185b77f960 274 SMART SM00382 46 249 4.9E-5 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS06210 fd6a2271ead66eb0a7a7fa185b77f960 274 Gene3D G3DSA:3.40.50.300 20 262 1.1E-55 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06210 fd6a2271ead66eb0a7a7fa185b77f960 274 SUPERFAMILY SSF52540 20 262 2.13E-55 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06210 fd6a2271ead66eb0a7a7fa185b77f960 274 Pfam PF00005 ABC transporter 38 192 2.0E-30 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS03500 3b512cdae71cd4910fde4176db295247 267 Pfam PF02405 Permease MlaE 51 254 8.1E-60 T 09-03-2017 IPR030802 ABC transporter permease MalE GO:0006810|GO:0043190 TK78_RS09150 b9438af7a45aebec4b161b3ac565c5ad 146 TIGRFAM TIGR02241 TIGR02241: conserved hypothetical phage tail region protein 5 145 4.1E-28 T 09-03-2017 IPR011747 Conserved hypothetical protein CHP02241 TK78_RS09150 b9438af7a45aebec4b161b3ac565c5ad 146 Pfam PF06841 T4-like virus tail tube protein gp19 11 143 2.1E-26 T 09-03-2017 IPR010667 Bacteriophage T4, Gp19, tail tube GO:0005198 TK78_RS28650 ab04b57deb00b42b626b5256330e12fe 372 Pfam PF13614 AAA domain 118 293 1.1E-61 T 09-03-2017 IPR025669 AAA domain TK78_RS28650 ab04b57deb00b42b626b5256330e12fe 372 SUPERFAMILY SSF52540 117 369 2.15E-64 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28650 ab04b57deb00b42b626b5256330e12fe 372 Gene3D G3DSA:3.40.50.300 118 369 2.3E-67 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01925 713095d5c4fb679f63ea5e42cac6ab8a 253 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 15 193 8.1E-7 T 09-03-2017 TK78_RS01925 713095d5c4fb679f63ea5e42cac6ab8a 253 Gene3D G3DSA:3.40.50.720 13 252 5.2E-75 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS01925 713095d5c4fb679f63ea5e42cac6ab8a 253 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 23 252 1.3E-55 T 09-03-2017 TK78_RS01925 713095d5c4fb679f63ea5e42cac6ab8a 253 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 149 177 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS01925 713095d5c4fb679f63ea5e42cac6ab8a 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 183 200 1.0E-34 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS01925 713095d5c4fb679f63ea5e42cac6ab8a 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 217 237 1.0E-34 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS01925 713095d5c4fb679f63ea5e42cac6ab8a 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 136 152 1.0E-34 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS01925 713095d5c4fb679f63ea5e42cac6ab8a 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 16 33 1.0E-34 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS01925 713095d5c4fb679f63ea5e42cac6ab8a 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 162 181 1.0E-34 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS01925 713095d5c4fb679f63ea5e42cac6ab8a 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 91 102 1.0E-34 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS01925 713095d5c4fb679f63ea5e42cac6ab8a 253 SUPERFAMILY SSF51735 15 252 2.95E-72 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS01925 713095d5c4fb679f63ea5e42cac6ab8a 253 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 142 150 1.4E-8 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS01925 713095d5c4fb679f63ea5e42cac6ab8a 253 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 91 102 1.4E-8 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS01925 713095d5c4fb679f63ea5e42cac6ab8a 253 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 162 181 1.4E-8 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS30780 3aafd0aa3645b338d2593f9be5389580 247 Pfam PF00376 MerR family regulatory protein 23 63 1.5E-11 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS30780 3aafd0aa3645b338d2593f9be5389580 247 SUPERFAMILY SSF46955 36 102 9.16E-13 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS30780 3aafd0aa3645b338d2593f9be5389580 247 Gene3D G3DSA:1.10.1660.10 36 101 3.4E-17 T 09-03-2017 TK78_RS30780 3aafd0aa3645b338d2593f9be5389580 247 SMART SM00422 21 95 6.9E-17 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS18480 4bcdf2f8fc8dabc0b1b87c7ddf0823e8 554 SUPERFAMILY SSF81606 221 417 4.45E-10 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS18480 4bcdf2f8fc8dabc0b1b87c7ddf0823e8 554 SMART SM00331 205 418 1.9E-41 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS18480 4bcdf2f8fc8dabc0b1b87c7ddf0823e8 554 SUPERFAMILY SSF55874 463 550 2.23E-5 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS18480 4bcdf2f8fc8dabc0b1b87c7ddf0823e8 554 Gene3D G3DSA:3.30.450.20 70 171 1.6E-10 T 09-03-2017 TK78_RS18480 4bcdf2f8fc8dabc0b1b87c7ddf0823e8 554 Pfam PF08448 PAS fold 75 172 4.5E-9 T 09-03-2017 IPR013656 PAS fold-4 TK78_RS18480 4bcdf2f8fc8dabc0b1b87c7ddf0823e8 554 SUPERFAMILY SSF55785 71 168 6.46E-8 T 09-03-2017 IPR000014 PAS domain TK78_RS18480 4bcdf2f8fc8dabc0b1b87c7ddf0823e8 554 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 235 418 1.2E-50 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS18480 4bcdf2f8fc8dabc0b1b87c7ddf0823e8 554 Pfam PF13581 Histidine kinase-like ATPase domain 442 533 1.9E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS13045 d9f5061010a88e214ddc08cdadbc6246 73 SMART SM00316 5 73 6.0E-5 T 09-03-2017 IPR022967 RNA-binding domain, S1 TK78_RS13045 d9f5061010a88e214ddc08cdadbc6246 73 SUPERFAMILY SSF50249 4 72 9.06E-28 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS13045 d9f5061010a88e214ddc08cdadbc6246 73 Pfam PF01176 Translation initiation factor 1A / IF-1 8 71 3.4E-29 T 09-03-2017 IPR006196 RNA-binding domain, S1, IF1 type GO:0003723|GO:0003743|GO:0006413 TK78_RS13045 d9f5061010a88e214ddc08cdadbc6246 73 Gene3D G3DSA:2.40.50.140 2 73 1.5E-39 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS13045 d9f5061010a88e214ddc08cdadbc6246 73 TIGRFAM TIGR00008 infA: translation initiation factor IF-1 4 72 6.4E-38 T 09-03-2017 IPR004368 Translation initiation factor IF-1 GO:0003743|GO:0006413 TK78_RS13045 d9f5061010a88e214ddc08cdadbc6246 73 Hamap MF_00075 Translation initiation factor IF-1 [infA]. 2 73 26.761 T 09-03-2017 IPR004368 Translation initiation factor IF-1 GO:0003743|GO:0006413 TK78_RS11780 24f5e095901049ccc1331fd178274fdc 188 Gene3D G3DSA:3.90.1570.10 13 161 3.7E-17 T 09-03-2017 IPR012296 Nuclease, putative, TT1808 TK78_RS11780 24f5e095901049ccc1331fd178274fdc 188 SUPERFAMILY SSF52980 12 147 5.9E-18 T 09-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 TK78_RS11780 24f5e095901049ccc1331fd178274fdc 188 Pfam PF05685 Putative restriction endonuclease 21 145 3.2E-19 T 09-03-2017 IPR008538 Domain of unknown function DUF820 TK78_RS14705 8c92807dbd0f1850880a97501fddaab8 325 Gene3D G3DSA:3.40.50.1980 163 325 1.4E-28 T 09-03-2017 TK78_RS14705 8c92807dbd0f1850880a97501fddaab8 325 SUPERFAMILY SSF53807 45 321 3.26E-59 T 09-03-2017 TK78_RS14705 8c92807dbd0f1850880a97501fddaab8 325 Pfam PF01497 Periplasmic binding protein 63 301 7.1E-31 T 09-03-2017 IPR002491 ABC transporter periplasmic binding domain GO:0005488 TK78_RS14705 8c92807dbd0f1850880a97501fddaab8 325 Gene3D G3DSA:3.40.50.1980 43 162 1.1E-35 T 09-03-2017 TK78_RS18250 9a5c95ca3a606aadd151ad4aa7dae5d0 168 Gene3D G3DSA:1.10.10.10 84 150 3.8E-11 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS18250 9a5c95ca3a606aadd151ad4aa7dae5d0 168 SUPERFAMILY SSF46785 83 149 1.25E-9 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS18250 9a5c95ca3a606aadd151ad4aa7dae5d0 168 Pfam PF12840 Helix-turn-helix domain 90 143 1.4E-8 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS18250 9a5c95ca3a606aadd151ad4aa7dae5d0 168 SMART SM00418 89 162 0.0082 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS09505 4f53b4ef9e6b06aca15902fe84d0b464 210 SUPERFAMILY SSF51219 7 205 4.45E-47 T 09-03-2017 IPR016031 Tryptophan RNA-binding attenuator protein-like domain TK78_RS09505 4f53b4ef9e6b06aca15902fe84d0b464 210 Gene3D G3DSA:3.60.160.10 7 204 2.1E-43 T 09-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 TK78_RS09505 4f53b4ef9e6b06aca15902fe84d0b464 210 Pfam PF01987 Mitochondrial biogenesis AIM24 3 200 6.1E-35 T 09-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 TK78_RS11030 7522154600d97c0a60f71ee479630813 328 SUPERFAMILY SSF161098 90 317 1.44E-61 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS11030 7522154600d97c0a60f71ee479630813 328 SUPERFAMILY SSF160964 41 85 4.18E-6 T 09-03-2017 TK78_RS11030 7522154600d97c0a60f71ee479630813 328 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 121 315 1.2E-12 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS11030 7522154600d97c0a60f71ee479630813 328 Gene3D G3DSA:1.10.3720.10 96 325 2.2E-65 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS11030 7522154600d97c0a60f71ee479630813 328 Gene3D G3DSA:1.20.58.370 41 75 8.8E-4 T 09-03-2017 TK78_RS23170 4041d666e43a114428564785079ffd5d 316 SUPERFAMILY SSF53335 59 271 2.52E-31 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS23170 4041d666e43a114428564785079ffd5d 316 Pfam PF08241 Methyltransferase domain 109 210 3.6E-5 T 09-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 TK78_RS23170 4041d666e43a114428564785079ffd5d 316 Gene3D G3DSA:3.40.50.150 56 302 1.3E-65 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS26000 b8898a9350a434df080249866e005e8b 267 Pfam PF01925 Sulfite exporter TauE/SafE 10 227 5.1E-28 T 09-03-2017 IPR002781 Transmembrane protein TauE-like GO:0016021 TK78_RS04630 a000f6493bfa0497e1fdf3fd6b609d97 228 SMART SM00448 5 116 5.9E-40 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS04630 a000f6493bfa0497e1fdf3fd6b609d97 228 Pfam PF00486 Transcriptional regulatory protein, C terminal 150 225 2.6E-25 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS04630 a000f6493bfa0497e1fdf3fd6b609d97 228 SUPERFAMILY SSF52172 3 125 1.28E-40 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS04630 a000f6493bfa0497e1fdf3fd6b609d97 228 Pfam PF00072 Response regulator receiver domain 7 117 2.1E-27 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS04630 a000f6493bfa0497e1fdf3fd6b609d97 228 Gene3D G3DSA:3.40.50.2300 4 124 4.5E-39 T 09-03-2017 TK78_RS04630 a000f6493bfa0497e1fdf3fd6b609d97 228 SUPERFAMILY SSF46894 127 226 2.83E-28 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS04630 a000f6493bfa0497e1fdf3fd6b609d97 228 SMART SM00862 150 225 6.3E-27 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS04630 a000f6493bfa0497e1fdf3fd6b609d97 228 Gene3D G3DSA:1.10.10.10 129 226 2.1E-31 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS26235 113bc6a792ed8e7d76156c93f1c4fd67 238 Gene3D G3DSA:1.10.357.10 98 234 2.1E-30 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS26235 113bc6a792ed8e7d76156c93f1c4fd67 238 Gene3D G3DSA:1.10.10.60 48 97 2.6E-19 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS26235 113bc6a792ed8e7d76156c93f1c4fd67 238 Pfam PF16859 Bacterial transcriptional repressor C-terminal 123 227 6.9E-20 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS26235 113bc6a792ed8e7d76156c93f1c4fd67 238 SUPERFAMILY SSF46689 48 109 7.83E-12 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS26235 113bc6a792ed8e7d76156c93f1c4fd67 238 SUPERFAMILY SSF48498 123 233 4.79E-20 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS26235 113bc6a792ed8e7d76156c93f1c4fd67 238 Pfam PF00440 Bacterial regulatory proteins, tetR family 72 103 1.4E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS34530 c25240f1dd2aeb4541dc0887a725c449 642 SUPERFAMILY SSF49319 224 326 2.49E-22 T 09-03-2017 IPR027273 Neocarzinostatin-like TK78_RS34530 c25240f1dd2aeb4541dc0887a725c449 642 Gene3D G3DSA:2.60.40.230 224 340 1.6E-24 T 09-03-2017 IPR027273 Neocarzinostatin-like TK78_RS34530 c25240f1dd2aeb4541dc0887a725c449 642 Pfam PF04213 Htaa 56 217 2.2E-34 T 09-03-2017 IPR007331 Htaa TK78_RS34530 c25240f1dd2aeb4541dc0887a725c449 642 Gene3D G3DSA:2.60.40.10 347 431 2.4E-4 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS34530 c25240f1dd2aeb4541dc0887a725c449 642 Pfam PF00960 Neocarzinostatin family 226 319 4.2E-10 T 09-03-2017 IPR002186 Neocarzinostatin family GO:0003677|GO:0006952 TK78_RS26730 e5d15b3ce44d94b63def03a109009841 118 TIGRFAM TIGR00049 TIGR00049: iron-sulfur cluster assembly accessory protein 14 118 4.3E-36 T 09-03-2017 IPR016092 FeS cluster insertion protein GO:0005198|GO:0016226|GO:0051536 TK78_RS26730 e5d15b3ce44d94b63def03a109009841 118 Gene3D G3DSA:2.60.300.12 14 108 1.2E-28 T 09-03-2017 IPR000361 FeS cluster biogenesis TK78_RS26730 e5d15b3ce44d94b63def03a109009841 118 SUPERFAMILY SSF89360 14 108 9.81E-28 T 09-03-2017 IPR000361 FeS cluster biogenesis TK78_RS26730 e5d15b3ce44d94b63def03a109009841 118 ProSitePatterns PS01152 Hypothetical hesB/yadR/yfhF family signature. 100 117 - T 09-03-2017 IPR017870 FeS cluster insertion, C-terminal, conserved site TK78_RS26730 e5d15b3ce44d94b63def03a109009841 118 Pfam PF01521 Iron-sulphur cluster biosynthesis 14 115 4.3E-19 T 09-03-2017 IPR000361 FeS cluster biogenesis TK78_RS20650 7623f01e5d8169de06d3406e9b91374e 239 Pfam PF05719 Golgi phosphoprotein 3 (GPP34) 8 202 2.1E-46 T 09-03-2017 IPR008628 Golgi phosphoprotein 3 GO:0048193|GO:0070273 TK78_RS20650 7623f01e5d8169de06d3406e9b91374e 239 Gene3D G3DSA:1.10.3630.10 3 214 4.4E-40 T 09-03-2017 TK78_RS19245 7414717911fd4a8096d960d5f068c279 121 Gene3D G3DSA:2.60.120.10 32 105 3.6E-10 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS19245 7414717911fd4a8096d960d5f068c279 121 SUPERFAMILY SSF51182 27 102 1.74E-9 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS05135 7c055d3c34e409282f9a2312eaa48f1a 187 SUPERFAMILY SSF50249 34 142 9.42E-18 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS05135 7c055d3c34e409282f9a2312eaa48f1a 187 Pfam PF04679 ATP dependent DNA ligase C terminal region 51 139 2.0E-16 T 09-03-2017 IPR012309 DNA ligase, ATP-dependent, C-terminal GO:0003910|GO:0006281|GO:0006310 TK78_RS05135 7c055d3c34e409282f9a2312eaa48f1a 187 Gene3D G3DSA:2.40.50.140 34 142 7.4E-26 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS05690 346e038c41d627aa8aa9f746e260dd60 227 SUPERFAMILY SSF52540 29 218 1.03E-32 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS05690 346e038c41d627aa8aa9f746e260dd60 227 Pfam PF00485 Phosphoribulokinase / Uridine kinase family 33 215 2.1E-8 T 09-03-2017 IPR006083 Phosphoribulokinase/uridine kinase GO:0005524|GO:0008152|GO:0016301 TK78_RS05690 346e038c41d627aa8aa9f746e260dd60 227 Gene3D G3DSA:3.40.50.300 19 215 2.6E-55 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS34480 f8e894cc6274af45f58a0abbcfbcdbdf 162 SUPERFAMILY SSF46785 13 156 4.97E-36 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS34480 f8e894cc6274af45f58a0abbcfbcdbdf 162 SMART SM00347 43 141 8.8E-27 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS34480 f8e894cc6274af45f58a0abbcfbcdbdf 162 Pfam PF01047 MarR family 50 108 4.0E-17 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS34480 f8e894cc6274af45f58a0abbcfbcdbdf 162 PRINTS PR00598 Bacterial regulatory protein MarR family signature 67 83 5.0E-5 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS34480 f8e894cc6274af45f58a0abbcfbcdbdf 162 PRINTS PR00598 Bacterial regulatory protein MarR family signature 84 99 5.0E-5 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS34480 f8e894cc6274af45f58a0abbcfbcdbdf 162 PRINTS PR00598 Bacterial regulatory protein MarR family signature 103 119 5.0E-5 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS34480 f8e894cc6274af45f58a0abbcfbcdbdf 162 Gene3D G3DSA:1.10.10.10 16 157 2.6E-41 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS16850 6391dd91a9ea88eb0ae1439b5a044c7e 340 SUPERFAMILY SSF48452 99 296 1.07E-5 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS02465 432da8f028d30b31a997246afd3cc273 253 SUPERFAMILY SSF51621 3 251 1.03E-54 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS02465 432da8f028d30b31a997246afd3cc273 253 Pfam PF13714 Phosphoenolpyruvate phosphomutase 13 248 1.5E-60 T 09-03-2017 TK78_RS02465 432da8f028d30b31a997246afd3cc273 253 Gene3D G3DSA:3.20.20.60 7 233 4.1E-58 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS04590 fa5506e0b695b536f38dcfbef7bb0431 309 TIGRFAM TIGR01692 HIBADH: 3-hydroxyisobutyrate dehydrogenase 7 293 1.1E-112 T 09-03-2017 IPR011548 3-hydroxyisobutyrate dehydrogenase GO:0008442|GO:0051287|GO:0055114 KEGG: 00280+1.1.1.31|Reactome: R-HSA-70895 TK78_RS04590 fa5506e0b695b536f38dcfbef7bb0431 309 PIRSF PIRSF000103 1 301 1.3E-78 T 09-03-2017 IPR015815 3-hydroxyisobutyrate dehydrogenase-related GO:0016491|GO:0055114 Reactome: R-HSA-70895 TK78_RS04590 fa5506e0b695b536f38dcfbef7bb0431 309 Gene3D G3DSA:3.40.50.720 3 162 8.3E-57 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS04590 fa5506e0b695b536f38dcfbef7bb0431 309 Gene3D G3DSA:1.10.1040.10 164 296 2.1E-41 T 09-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 TK78_RS04590 fa5506e0b695b536f38dcfbef7bb0431 309 Pfam PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase 5 162 2.6E-46 T 09-03-2017 IPR006115 6-phosphogluconate dehydrogenase, NADP-binding GO:0004616|GO:0055114 TK78_RS04590 fa5506e0b695b536f38dcfbef7bb0431 309 ProSitePatterns PS00895 3-hydroxyisobutyrate dehydrogenase signature. 7 20 - T 09-03-2017 IPR002204 3-hydroxyisobutyrate dehydrogenase-related, conserved site GO:0016491|GO:0055114 Reactome: R-HSA-70895 TK78_RS04590 fa5506e0b695b536f38dcfbef7bb0431 309 SUPERFAMILY SSF48179 164 293 2.72E-36 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS04590 fa5506e0b695b536f38dcfbef7bb0431 309 SUPERFAMILY SSF51735 3 163 8.54E-43 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS04590 fa5506e0b695b536f38dcfbef7bb0431 309 Pfam PF14833 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 165 291 1.4E-36 T 09-03-2017 IPR029154 3-hydroxyisobutyrate dehydrogenase, NAD-binding domain GO:0051287 TK78_RS04110 5c9645bab6277a11dfb67b2a379bc2da 298 Pfam PF00491 Arginase family 19 292 1.8E-23 T 09-03-2017 IPR006035 Ureohydrolase GO:0046872 TK78_RS04110 5c9645bab6277a11dfb67b2a379bc2da 298 SUPERFAMILY SSF52768 3 295 3.6E-46 T 09-03-2017 TK78_RS04110 5c9645bab6277a11dfb67b2a379bc2da 298 Gene3D G3DSA:3.40.800.10 3 295 2.0E-43 T 09-03-2017 IPR023696 Ureohydrolase domain TK78_RS04110 5c9645bab6277a11dfb67b2a379bc2da 298 PRINTS PR00116 Arginase signature 222 251 5.0E-5 T 09-03-2017 IPR006035 Ureohydrolase GO:0046872 TK78_RS04110 5c9645bab6277a11dfb67b2a379bc2da 298 PRINTS PR00116 Arginase signature 96 111 5.0E-5 T 09-03-2017 IPR006035 Ureohydrolase GO:0046872 TK78_RS06300 23edda757da8f8fcf32d60921b5505e6 279 Gene3D G3DSA:3.90.550.10 10 109 2.1E-9 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS06300 23edda757da8f8fcf32d60921b5505e6 279 Pfam PF00535 Glycosyl transferase family 2 12 132 2.5E-14 T 09-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 TK78_RS06300 23edda757da8f8fcf32d60921b5505e6 279 SUPERFAMILY SSF53448 9 140 1.06E-20 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS00475 2414edcff45afd1edc0a89e84a87ed8d 311 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 108 298 1.4E-8 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS00475 2414edcff45afd1edc0a89e84a87ed8d 311 Gene3D G3DSA:1.10.3720.10 27 299 1.1E-44 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS00475 2414edcff45afd1edc0a89e84a87ed8d 311 SUPERFAMILY SSF161098 73 298 9.03E-46 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS34680 0b35060fb9e20373bc48d433f842f02f 438 Pfam PF07690 Major Facilitator Superfamily 35 338 3.0E-8 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS34680 0b35060fb9e20373bc48d433f842f02f 438 SUPERFAMILY SSF103473 43 410 2.88E-23 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS34680 0b35060fb9e20373bc48d433f842f02f 438 Gene3D G3DSA:1.20.1250.20 235 408 1.4E-5 T 09-03-2017 TK78_RS34680 0b35060fb9e20373bc48d433f842f02f 438 Gene3D G3DSA:1.20.1250.20 25 199 5.5E-8 T 09-03-2017 TK78_RS17375 0c88252424bb90716f7c5714e385e22e 376 Pfam PF00712 DNA polymerase III beta subunit, N-terminal domain 2 118 9.4E-39 T 09-03-2017 IPR022634 DNA polymerase III, beta chain, N-terminal GO:0003677|GO:0003887|GO:0006260|GO:0008408|GO:0009360 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS17375 0c88252424bb90716f7c5714e385e22e 376 SMART SM00480 17 370 1.8E-142 T 09-03-2017 IPR001001 DNA polymerase III, beta chain GO:0003677|GO:0003887|GO:0006260|GO:0008408|GO:0009360 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS17375 0c88252424bb90716f7c5714e385e22e 376 Gene3D G3DSA:3.10.150.10 2 120 9.8E-32 T 09-03-2017 TK78_RS17375 0c88252424bb90716f7c5714e385e22e 376 Gene3D G3DSA:3.10.150.10 126 250 3.3E-29 T 09-03-2017 TK78_RS17375 0c88252424bb90716f7c5714e385e22e 376 SUPERFAMILY SSF55979 249 374 3.14E-29 T 09-03-2017 TK78_RS17375 0c88252424bb90716f7c5714e385e22e 376 PIRSF PIRSF000804 1 375 5.7E-93 T 09-03-2017 IPR001001 DNA polymerase III, beta chain GO:0003677|GO:0003887|GO:0006260|GO:0008408|GO:0009360 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS17375 0c88252424bb90716f7c5714e385e22e 376 Pfam PF02767 DNA polymerase III beta subunit, central domain 127 246 3.1E-32 T 09-03-2017 IPR022637 DNA polymerase III, beta chain, central GO:0003887|GO:0006260|GO:0008408|GO:0009360 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS17375 0c88252424bb90716f7c5714e385e22e 376 SUPERFAMILY SSF55979 126 249 1.3E-18 T 09-03-2017 TK78_RS17375 0c88252424bb90716f7c5714e385e22e 376 SUPERFAMILY SSF55979 2 119 3.38E-24 T 09-03-2017 TK78_RS17375 0c88252424bb90716f7c5714e385e22e 376 Pfam PF02768 DNA polymerase III beta subunit, C-terminal domain 248 373 8.3E-36 T 09-03-2017 IPR022635 DNA polymerase III, beta chain, C-terminal GO:0003677|GO:0003887|GO:0006260|GO:0008408|GO:0009360 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS17375 0c88252424bb90716f7c5714e385e22e 376 TIGRFAM TIGR00663 dnan: DNA polymerase III, beta subunit 1 374 1.0E-90 T 09-03-2017 IPR001001 DNA polymerase III, beta chain GO:0003677|GO:0003887|GO:0006260|GO:0008408|GO:0009360 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TK78_RS17375 0c88252424bb90716f7c5714e385e22e 376 Gene3D G3DSA:3.10.150.10 252 374 1.2E-37 T 09-03-2017 TK78_RS21350 f72d14e383cc543d4637194d51481def 197 Gene3D G3DSA:3.40.50.1470 4 196 3.0E-68 T 09-03-2017 IPR001328 Peptidyl-tRNA hydrolase GO:0004045 MetaCyc: PWY-6308 TK78_RS21350 f72d14e383cc543d4637194d51481def 197 ProSitePatterns PS01196 Peptidyl-tRNA hydrolase signature 2. 119 129 - T 09-03-2017 IPR018171 Peptidyl-tRNA hydrolase, conserved site GO:0004045 MetaCyc: PWY-6308 TK78_RS21350 f72d14e383cc543d4637194d51481def 197 TIGRFAM TIGR00447 pth: aminoacyl-tRNA hydrolase 9 197 5.5E-52 T 09-03-2017 IPR001328 Peptidyl-tRNA hydrolase GO:0004045 MetaCyc: PWY-6308 TK78_RS21350 f72d14e383cc543d4637194d51481def 197 ProSitePatterns PS01195 Peptidyl-tRNA hydrolase signature 1. 20 33 - T 09-03-2017 IPR018171 Peptidyl-tRNA hydrolase, conserved site GO:0004045 MetaCyc: PWY-6308 TK78_RS21350 f72d14e383cc543d4637194d51481def 197 Hamap MF_00083 Peptidyl-tRNA hydrolase [pth]. 7 189 32.658 T 09-03-2017 IPR001328 Peptidyl-tRNA hydrolase GO:0004045 MetaCyc: PWY-6308 TK78_RS21350 f72d14e383cc543d4637194d51481def 197 Pfam PF01195 Peptidyl-tRNA hydrolase 9 194 1.9E-51 T 09-03-2017 IPR001328 Peptidyl-tRNA hydrolase GO:0004045 MetaCyc: PWY-6308 TK78_RS21350 f72d14e383cc543d4637194d51481def 197 SUPERFAMILY SSF53178 7 196 1.31E-62 T 09-03-2017 IPR001328 Peptidyl-tRNA hydrolase GO:0004045 MetaCyc: PWY-6308 TK78_RS34625 a124a778414acc52668b0d43f47f80ac 558 SUPERFAMILY SSF52172 12 139 3.7E-22 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS34625 a124a778414acc52668b0d43f47f80ac 558 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 508 530 6.7E-22 T 09-03-2017 TK78_RS34625 a124a778414acc52668b0d43f47f80ac 558 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 235 254 6.7E-22 T 09-03-2017 TK78_RS34625 a124a778414acc52668b0d43f47f80ac 558 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 463 479 6.7E-22 T 09-03-2017 TK78_RS34625 a124a778414acc52668b0d43f47f80ac 558 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 334 352 6.7E-22 T 09-03-2017 TK78_RS34625 a124a778414acc52668b0d43f47f80ac 558 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 377 395 6.7E-22 T 09-03-2017 TK78_RS34625 a124a778414acc52668b0d43f47f80ac 558 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 233 544 1.2E-27 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS34625 a124a778414acc52668b0d43f47f80ac 558 Gene3D G3DSA:3.40.50.2300 12 141 5.8E-23 T 09-03-2017 TK78_RS34625 a124a778414acc52668b0d43f47f80ac 558 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 234 256 5.4E-31 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS34625 a124a778414acc52668b0d43f47f80ac 558 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 373 397 5.4E-31 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS34625 a124a778414acc52668b0d43f47f80ac 558 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 427 443 5.4E-31 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS34625 a124a778414acc52668b0d43f47f80ac 558 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 267 282 5.4E-31 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS34625 a124a778414acc52668b0d43f47f80ac 558 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 465 486 5.4E-31 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS34625 a124a778414acc52668b0d43f47f80ac 558 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 335 343 5.4E-31 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS34625 a124a778414acc52668b0d43f47f80ac 558 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 288 298 5.4E-31 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS34625 a124a778414acc52668b0d43f47f80ac 558 Gene3D G3DSA:3.50.50.60 232 337 4.6E-30 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS34625 a124a778414acc52668b0d43f47f80ac 558 SMART SM00448 10 132 2.7E-12 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS34625 a124a778414acc52668b0d43f47f80ac 558 Gene3D G3DSA:3.50.50.60 338 550 7.0E-25 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS34625 a124a778414acc52668b0d43f47f80ac 558 Pfam PF00072 Response regulator receiver domain 12 125 5.3E-14 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS34625 a124a778414acc52668b0d43f47f80ac 558 SUPERFAMILY SSF51905 231 492 1.73E-38 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS08180 be1e439b05b6cae399933eeba069d60d 294 Gene3D G3DSA:3.40.50.150 24 223 5.7E-14 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS08180 be1e439b05b6cae399933eeba069d60d 294 SUPERFAMILY SSF53335 24 223 4.22E-16 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS10900 89d0526322a2aad8063eb110da177204 168 Pfam PF14085 Domain of unknown function (DUF4265) 36 156 8.7E-31 T 09-03-2017 IPR025361 Protein of unknown function DUF4265 TK78_RS18050 175623770ff8439a7803e8e95c0d3689 326 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 24 312 1.8E-69 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS18050 175623770ff8439a7803e8e95c0d3689 326 Gene3D G3DSA:3.40.50.1100 166 321 1.8E-65 T 09-03-2017 TK78_RS18050 175623770ff8439a7803e8e95c0d3689 326 Gene3D G3DSA:3.40.50.1100 19 58 1.8E-65 T 09-03-2017 TK78_RS18050 175623770ff8439a7803e8e95c0d3689 326 SUPERFAMILY SSF53686 19 323 2.23E-95 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS18050 175623770ff8439a7803e8e95c0d3689 326 Gene3D G3DSA:3.40.50.1100 59 158 2.3E-37 T 09-03-2017 TK78_RS08685 ee3f2d2204ffd4eb436c51d7b08331ed 343 SUPERFAMILY SSF55909 5 342 1.96E-120 T 09-03-2017 TK78_RS08685 ee3f2d2204ffd4eb436c51d7b08331ed 343 Gene3D G3DSA:3.75.10.10 5 342 2.1E-122 T 09-03-2017 TK78_RS08685 ee3f2d2204ffd4eb436c51d7b08331ed 343 Pfam PF04371 Porphyromonas-type peptidyl-arginine deiminase 9 341 9.3E-110 T 09-03-2017 IPR007466 Peptidyl-arginine deiminase, Porphyromonas-type GO:0004668|GO:0009446 KEGG: 00330+3.5.3.12|MetaCyc: PWY-43 TK78_RS31525 c6f9ea49f49693b7162ee3aa8e34bb85 146 Gene3D G3DSA:3.40.630.30 9 140 4.9E-29 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS31525 c6f9ea49f49693b7162ee3aa8e34bb85 146 SUPERFAMILY SSF55729 4 140 5.98E-28 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS31525 c6f9ea49f49693b7162ee3aa8e34bb85 146 Pfam PF00583 Acetyltransferase (GNAT) family 56 131 6.4E-15 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS07370 b303bbcb93233ae1834b5e8925d1dda6 631 Pfam PF04183 IucA / IucC family 192 419 6.7E-68 T 09-03-2017 IPR007310 Aerobactin siderophore biosynthesis, IucA/IucC, N-terminal GO:0015343|GO:0019290 TK78_RS07370 b303bbcb93233ae1834b5e8925d1dda6 631 Pfam PF06276 Ferric iron reductase FhuF-like transporter 455 612 1.7E-29 T 09-03-2017 IPR022770 Ferric iron reductase FhuF domain TK78_RS04920 dcf71bd876ec61aaaef48cca38a603a8 539 PIRSF PIRSF001363 2 539 4.1E-241 T 09-03-2017 IPR006252 Malate synthase A GO:0004474|GO:0006097 KEGG: 00620+2.3.3.9|KEGG: 00630+2.3.3.9|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7118|MetaCyc: PWY-7294|MetaCyc: PWY-7295 TK78_RS04920 dcf71bd876ec61aaaef48cca38a603a8 539 SUPERFAMILY SSF51645 17 538 4.71E-181 T 09-03-2017 IPR011076 Malate synthase-like GO:0003824 KEGG: 00620+2.3.3.9|KEGG: 00630+2.3.3.9|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7118|MetaCyc: PWY-7294|MetaCyc: PWY-7295 TK78_RS04920 dcf71bd876ec61aaaef48cca38a603a8 539 ProSitePatterns PS00510 Malate synthase signature. 269 284 - T 09-03-2017 IPR019830 Malate synthase, conserved site GO:0004474|GO:0006097 KEGG: 00620+2.3.3.9|KEGG: 00630+2.3.3.9|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7118|MetaCyc: PWY-7294|MetaCyc: PWY-7295 TK78_RS04920 dcf71bd876ec61aaaef48cca38a603a8 539 TIGRFAM TIGR01344 malate_syn_A: malate synthase A 23 538 2.4E-252 T 09-03-2017 IPR006252 Malate synthase A GO:0004474|GO:0006097 KEGG: 00620+2.3.3.9|KEGG: 00630+2.3.3.9|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7118|MetaCyc: PWY-7294|MetaCyc: PWY-7295 TK78_RS04920 dcf71bd876ec61aaaef48cca38a603a8 539 Pfam PF01274 Malate synthase 18 538 2.1E-201 T 09-03-2017 IPR001465 Malate synthase GO:0004474|GO:0006097 KEGG: 00620+2.3.3.9|KEGG: 00630+2.3.3.9|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7118|MetaCyc: PWY-7294|MetaCyc: PWY-7295 TK78_RS04920 dcf71bd876ec61aaaef48cca38a603a8 539 Gene3D G3DSA:3.20.20.360 73 414 9.6E-116 T 09-03-2017 TK78_RS04920 dcf71bd876ec61aaaef48cca38a603a8 539 Gene3D G3DSA:1.20.1220.12 420 532 5.2E-26 T 09-03-2017 TK78_RS24075 cdef85df31c1285f9ac07b58b3726ed3 339 SMART SM00382 68 259 6.3E-14 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS24075 cdef85df31c1285f9ac07b58b3726ed3 339 Gene3D G3DSA:3.40.50.300 54 260 1.7E-61 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24075 cdef85df31c1285f9ac07b58b3726ed3 339 ProSitePatterns PS00211 ABC transporters family signature. 183 197 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS24075 cdef85df31c1285f9ac07b58b3726ed3 339 Pfam PF00005 ABC transporter 59 210 4.2E-29 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS24075 cdef85df31c1285f9ac07b58b3726ed3 339 SUPERFAMILY SSF52540 39 261 1.9E-62 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23520 3b01aace61f5f7b50101b6c6900c1378 294 Gene3D G3DSA:3.10.129.10 128 291 1.6E-52 T 09-03-2017 IPR029069 HotDog domain TK78_RS23520 3b01aace61f5f7b50101b6c6900c1378 294 SUPERFAMILY SSF54637 8 117 5.97E-41 T 09-03-2017 IPR029069 HotDog domain TK78_RS23520 3b01aace61f5f7b50101b6c6900c1378 294 Gene3D G3DSA:3.10.129.10 8 118 3.6E-47 T 09-03-2017 IPR029069 HotDog domain TK78_RS23520 3b01aace61f5f7b50101b6c6900c1378 294 Pfam PF13622 Thioesterase-like superfamily 36 289 9.2E-60 T 09-03-2017 TK78_RS23520 3b01aace61f5f7b50101b6c6900c1378 294 SUPERFAMILY SSF54637 119 293 1.57E-48 T 09-03-2017 IPR029069 HotDog domain TK78_RS33280 74304720819f12909dd588b33497722b 141 Gene3D G3DSA:3.10.450.50 3 121 8.3E-18 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS33280 74304720819f12909dd588b33497722b 141 Pfam PF12680 SnoaL-like domain 5 110 2.1E-12 T 09-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain TK78_RS33280 74304720819f12909dd588b33497722b 141 SUPERFAMILY SSF54427 2 117 1.17E-19 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS30220 e327907db0caf49d8c8a0ddb52e94d5c 737 Gene3D G3DSA:3.40.50.300 33 160 9.3E-8 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS30220 e327907db0caf49d8c8a0ddb52e94d5c 737 SUPERFAMILY SSF52540 23 269 1.1E-20 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS30220 e327907db0caf49d8c8a0ddb52e94d5c 737 Gene3D G3DSA:1.25.40.10 448 638 8.5E-18 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS30220 e327907db0caf49d8c8a0ddb52e94d5c 737 SUPERFAMILY SSF48452 489 630 1.14E-14 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS30220 e327907db0caf49d8c8a0ddb52e94d5c 737 Pfam PF13401 AAA domain 50 149 1.6E-6 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS30220 e327907db0caf49d8c8a0ddb52e94d5c 737 PRINTS PR00364 Disease resistance protein signature 120 134 1.1E-5 T 09-03-2017 TK78_RS30220 e327907db0caf49d8c8a0ddb52e94d5c 737 PRINTS PR00364 Disease resistance protein signature 51 66 1.1E-5 T 09-03-2017 TK78_RS30220 e327907db0caf49d8c8a0ddb52e94d5c 737 PRINTS PR00364 Disease resistance protein signature 214 228 1.1E-5 T 09-03-2017 TK78_RS30220 e327907db0caf49d8c8a0ddb52e94d5c 737 SUPERFAMILY SSF48452 425 520 6.32E-6 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS25575 6c1285d80a2bf59aaa51e1e640a26b60 402 Pfam PF06259 Alpha/beta hydrolase 157 330 9.8E-57 T 09-03-2017 IPR010427 Protein of unknown function DUF1023 TK78_RS25575 6c1285d80a2bf59aaa51e1e640a26b60 402 SUPERFAMILY SSF53474 246 328 4.1E-7 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS25575 6c1285d80a2bf59aaa51e1e640a26b60 402 Gene3D G3DSA:3.40.50.1820 241 356 2.8E-7 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS25575 6c1285d80a2bf59aaa51e1e640a26b60 402 Gene3D G3DSA:3.40.50.1820 145 169 2.8E-7 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS03600 c9a5b443865acfa95a257253157ec6b7 448 Gene3D G3DSA:3.90.110.10 164 440 7.0E-97 T 09-03-2017 IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal GO:0003824|GO:0005975|GO:0016616|GO:0055114 TK78_RS03600 c9a5b443865acfa95a257253157ec6b7 448 SUPERFAMILY SSF56327 164 442 1.44E-67 T 09-03-2017 IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal GO:0003824|GO:0005975|GO:0016616|GO:0055114 TK78_RS03600 c9a5b443865acfa95a257253157ec6b7 448 Pfam PF02056 Family 4 glycosyl hydrolase 2 180 6.4E-43 T 09-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 TK78_RS03600 c9a5b443865acfa95a257253157ec6b7 448 Pfam PF11975 Family 4 glycosyl hydrolase C-terminal domain 190 422 1.0E-48 T 09-03-2017 IPR022616 Glycosyl hydrolase, family 4, C-terminal GO:0004553 TK78_RS03600 c9a5b443865acfa95a257253157ec6b7 448 ProSitePatterns PS01324 Glycosyl hydrolases family 4 signature. 135 165 - T 09-03-2017 IPR019802 Glycoside hydrolase, family 4, conserved site GO:0004553|GO:0005975 TK78_RS03600 c9a5b443865acfa95a257253157ec6b7 448 SUPERFAMILY SSF51735 2 163 2.18E-46 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS03600 c9a5b443865acfa95a257253157ec6b7 448 Gene3D G3DSA:3.40.50.720 1 163 1.2E-57 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS03600 c9a5b443865acfa95a257253157ec6b7 448 PRINTS PR00732 Glycosyl hydrolase family 4 signature 92 105 3.6E-38 T 09-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 TK78_RS03600 c9a5b443865acfa95a257253157ec6b7 448 PRINTS PR00732 Glycosyl hydrolase family 4 signature 135 152 3.6E-38 T 09-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 TK78_RS03600 c9a5b443865acfa95a257253157ec6b7 448 PRINTS PR00732 Glycosyl hydrolase family 4 signature 186 198 3.6E-38 T 09-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 TK78_RS03600 c9a5b443865acfa95a257253157ec6b7 448 PRINTS PR00732 Glycosyl hydrolase family 4 signature 160 171 3.6E-38 T 09-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 TK78_RS03600 c9a5b443865acfa95a257253157ec6b7 448 PRINTS PR00732 Glycosyl hydrolase family 4 signature 2 17 3.6E-38 T 09-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 TK78_RS03600 c9a5b443865acfa95a257253157ec6b7 448 PRINTS PR00732 Glycosyl hydrolase family 4 signature 106 126 3.6E-38 T 09-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 TK78_RS03600 c9a5b443865acfa95a257253157ec6b7 448 PRINTS PR00732 Glycosyl hydrolase family 4 signature 71 87 3.6E-38 T 09-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 TK78_RS05630 6f7b81afdc00c21545d317372aa3aae9 790 Gene3D G3DSA:3.20.20.80 485 524 9.3E-66 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS05630 6f7b81afdc00c21545d317372aa3aae9 790 Gene3D G3DSA:3.20.20.80 625 723 9.3E-66 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS05630 6f7b81afdc00c21545d317372aa3aae9 790 Gene3D G3DSA:3.20.20.80 224 296 9.3E-66 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS05630 6f7b81afdc00c21545d317372aa3aae9 790 Gene3D G3DSA:3.20.20.80 2 92 9.3E-66 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS05630 6f7b81afdc00c21545d317372aa3aae9 790 Gene3D G3DSA:1.10.10.470 525 606 2.6E-17 T 09-03-2017 IPR013797 Maltooligosyl trehalose synthase, N-terminal MetaCyc: PWY-2661 TK78_RS05630 6f7b81afdc00c21545d317372aa3aae9 790 TIGRFAM TIGR02401 trehalose_TreY: malto-oligosyltrehalose synthase 3 786 9.0E-255 T 09-03-2017 IPR012767 Malto-oligosyltrehalose synthase MetaCyc: PWY-2661 TK78_RS05630 6f7b81afdc00c21545d317372aa3aae9 790 Pfam PF00128 Alpha amylase, catalytic domain 24 97 1.8E-13 T 09-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 TK78_RS05630 6f7b81afdc00c21545d317372aa3aae9 790 Gene3D G3DSA:3.30.1590.10 93 208 1.7E-36 T 09-03-2017 TK78_RS05630 6f7b81afdc00c21545d317372aa3aae9 790 SUPERFAMILY SSF51445 435 695 2.75E-113 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS05630 6f7b81afdc00c21545d317372aa3aae9 790 SUPERFAMILY SSF51445 5 384 2.75E-113 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS05630 6f7b81afdc00c21545d317372aa3aae9 790 SMART SM00642 10 689 1.0E-6 T 09-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 TK78_RS06680 e2a42ab11a5d989dc6b7be0fa8c9e5ea 193 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 29 52 4.6E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS06680 e2a42ab11a5d989dc6b7be0fa8c9e5ea 193 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 8 21 4.6E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS06680 e2a42ab11a5d989dc6b7be0fa8c9e5ea 193 SUPERFAMILY SSF46689 4 75 5.99E-16 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS06680 e2a42ab11a5d989dc6b7be0fa8c9e5ea 193 Pfam PF00440 Bacterial regulatory proteins, tetR family 8 52 3.2E-14 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS06680 e2a42ab11a5d989dc6b7be0fa8c9e5ea 193 Gene3D G3DSA:1.10.357.10 4 180 6.5E-30 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS06680 e2a42ab11a5d989dc6b7be0fa8c9e5ea 193 SUPERFAMILY SSF48498 78 185 1.06E-12 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS06680 e2a42ab11a5d989dc6b7be0fa8c9e5ea 193 Pfam PF13977 Bacterial transcriptional repressor 78 187 2.0E-16 T 09-03-2017 TK78_RS01210 da23160f3e2cd0759ac26de810d64112 329 SUPERFAMILY SSF51735 135 281 1.39E-23 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS01210 da23160f3e2cd0759ac26de810d64112 329 Pfam PF00107 Zinc-binding dehydrogenase 171 288 3.8E-12 T 09-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 TK78_RS01210 da23160f3e2cd0759ac26de810d64112 329 SUPERFAMILY SSF50129 1 138 1.14E-53 T 09-03-2017 IPR011032 GroES-like TK78_RS01210 da23160f3e2cd0759ac26de810d64112 329 SUPERFAMILY SSF50129 300 327 1.14E-53 T 09-03-2017 IPR011032 GroES-like TK78_RS01210 da23160f3e2cd0759ac26de810d64112 329 Gene3D G3DSA:3.90.180.10 1 173 7.2E-59 T 09-03-2017 IPR011032 GroES-like TK78_RS01210 da23160f3e2cd0759ac26de810d64112 329 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 25 129 1.1E-33 T 09-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 TK78_RS01210 da23160f3e2cd0759ac26de810d64112 329 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 57 71 - T 09-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 TK78_RS01210 da23160f3e2cd0759ac26de810d64112 329 Gene3D G3DSA:3.40.50.720 174 276 5.7E-20 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS01210 da23160f3e2cd0759ac26de810d64112 329 SMART SM00829 7 327 0.0016 T 09-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 TK78_RS22935 e8f8191afbd916e0da7c805c95d9c0dd 386 Pfam PF13412 Winged helix-turn-helix DNA-binding 35 65 4.8E-5 T 09-03-2017 TK78_RS22935 e8f8191afbd916e0da7c805c95d9c0dd 386 Gene3D G3DSA:1.10.10.10 17 86 5.9E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS22935 e8f8191afbd916e0da7c805c95d9c0dd 386 SUPERFAMILY SSF53067 92 361 6.48E-38 T 09-03-2017 TK78_RS22935 e8f8191afbd916e0da7c805c95d9c0dd 386 Gene3D G3DSA:3.30.420.40 282 329 1.4E-6 T 09-03-2017 TK78_RS22935 e8f8191afbd916e0da7c805c95d9c0dd 386 Gene3D G3DSA:3.30.420.40 87 227 1.3E-53 T 09-03-2017 TK78_RS22935 e8f8191afbd916e0da7c805c95d9c0dd 386 Pfam PF00480 ROK family 133 271 3.5E-29 T 09-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 TK78_RS22935 e8f8191afbd916e0da7c805c95d9c0dd 386 SUPERFAMILY SSF46785 17 82 1.36E-9 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS22935 e8f8191afbd916e0da7c805c95d9c0dd 386 Gene3D G3DSA:3.30.420.40 228 272 2.4E-19 T 09-03-2017 TK78_RS22935 e8f8191afbd916e0da7c805c95d9c0dd 386 ProSitePatterns PS01125 ROK family signature. 222 249 - T 09-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 TK78_RS24800 b6e492a69817724056b37baf9d8f2fe7 451 Pfam PF07690 Major Facilitator Superfamily 13 310 8.9E-9 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS24800 b6e492a69817724056b37baf9d8f2fe7 451 SUPERFAMILY SSF103473 8 376 1.7E-27 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS24800 b6e492a69817724056b37baf9d8f2fe7 451 Gene3D G3DSA:1.20.1250.20 197 364 1.0E-9 T 09-03-2017 TK78_RS24800 b6e492a69817724056b37baf9d8f2fe7 451 Gene3D G3DSA:1.20.1250.20 12 175 9.8E-12 T 09-03-2017 TK78_RS08350 41365a334a29ed1dbaf1ac583f009c79 217 Gene3D G3DSA:4.10.520.10 1 89 3.1E-27 T 09-03-2017 IPR010992 Integration host factor (IHF)-like DNA-binding domain GO:0003677 TK78_RS08350 41365a334a29ed1dbaf1ac583f009c79 217 PRINTS PR01727 Prokaryotic integration host factor signature 73 87 4.5E-13 T 09-03-2017 IPR000119 Histone-like DNA-binding protein GO:0003677 TK78_RS08350 41365a334a29ed1dbaf1ac583f009c79 217 PRINTS PR01727 Prokaryotic integration host factor signature 39 54 4.5E-13 T 09-03-2017 IPR000119 Histone-like DNA-binding protein GO:0003677 TK78_RS08350 41365a334a29ed1dbaf1ac583f009c79 217 PRINTS PR01727 Prokaryotic integration host factor signature 57 70 4.5E-13 T 09-03-2017 IPR000119 Histone-like DNA-binding protein GO:0003677 TK78_RS08350 41365a334a29ed1dbaf1ac583f009c79 217 Pfam PF00216 Bacterial DNA-binding protein 1 88 4.1E-23 T 09-03-2017 IPR000119 Histone-like DNA-binding protein GO:0003677 TK78_RS08350 41365a334a29ed1dbaf1ac583f009c79 217 SMART SM00411 1 89 2.9E-38 T 09-03-2017 IPR000119 Histone-like DNA-binding protein GO:0003677 TK78_RS08350 41365a334a29ed1dbaf1ac583f009c79 217 SUPERFAMILY SSF47729 1 92 1.91E-24 T 09-03-2017 IPR010992 Integration host factor (IHF)-like DNA-binding domain GO:0003677 TK78_RS08350 41365a334a29ed1dbaf1ac583f009c79 217 ProSitePatterns PS00045 Bacterial histone-like DNA-binding proteins signature. 45 64 - T 09-03-2017 IPR020816 Histone-like DNA-binding protein, conserved site GO:0003677 TK78_RS07090 e6593a3b270032ed8f95b474e250b61f 265 PIRSF PIRSF006648 1 264 3.9E-64 T 09-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 TK78_RS07090 e6593a3b270032ed8f95b474e250b61f 265 Pfam PF01061 ABC-2 type transporter 21 228 3.3E-25 T 09-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 TK78_RS07090 e6593a3b270032ed8f95b474e250b61f 265 PRINTS PR00164 ABC-2 type transport system membrane protein signature 186 205 3.6E-5 T 09-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 TK78_RS07090 e6593a3b270032ed8f95b474e250b61f 265 PRINTS PR00164 ABC-2 type transport system membrane protein signature 67 89 3.6E-5 T 09-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 TK78_RS07090 e6593a3b270032ed8f95b474e250b61f 265 PRINTS PR00164 ABC-2 type transport system membrane protein signature 110 135 3.6E-5 T 09-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 TK78_RS00595 1dce8e6bc0381560ed13e94cc8a37c86 369 SUPERFAMILY SSF81345 27 362 1.02E-77 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS00595 1dce8e6bc0381560ed13e94cc8a37c86 369 Pfam PF01032 FecCD transport family 43 361 1.4E-89 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS00595 1dce8e6bc0381560ed13e94cc8a37c86 369 Gene3D G3DSA:1.10.3470.10 32 363 2.8E-100 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS21060 c4144f5b6bc71190244126c3828310ce 388 SUPERFAMILY SSF56601 8 199 2.43E-66 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS21060 c4144f5b6bc71190244126c3828310ce 388 SUPERFAMILY SSF56601 236 384 2.43E-66 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS21060 c4144f5b6bc71190244126c3828310ce 388 Gene3D G3DSA:3.40.710.10 249 386 9.8E-76 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS21060 c4144f5b6bc71190244126c3828310ce 388 Gene3D G3DSA:3.40.710.10 7 214 9.8E-76 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS21060 c4144f5b6bc71190244126c3828310ce 388 Pfam PF00144 Beta-lactamase 20 380 1.6E-69 T 09-03-2017 IPR001466 Beta-lactamase-related TK78_RS16520 f70129d7e7df185b5cc59da6072e59c0 211 TIGRFAM TIGR01091 upp: uracil phosphoribosyltransferase 3 209 2.6E-77 T 09-03-2017 IPR005765 Uracil phosphoribosyl transferase GO:0004845|GO:0006223 KEGG: 00240+2.4.2.9|MetaCyc: PWY-7183 TK78_RS16520 f70129d7e7df185b5cc59da6072e59c0 211 SUPERFAMILY SSF53271 3 208 8.65E-65 T 09-03-2017 IPR029057 Phosphoribosyltransferase-like TK78_RS16520 f70129d7e7df185b5cc59da6072e59c0 211 Hamap MF_01218_B Uracil phosphoribosyltransferase [upp]. 2 210 44.215 T 09-03-2017 IPR005765 Uracil phosphoribosyl transferase GO:0004845|GO:0006223 KEGG: 00240+2.4.2.9|MetaCyc: PWY-7183 TK78_RS16520 f70129d7e7df185b5cc59da6072e59c0 211 Pfam PF14681 Uracil phosphoribosyltransferase 5 209 2.3E-65 T 09-03-2017 IPR029057 Phosphoribosyltransferase-like TK78_RS16520 f70129d7e7df185b5cc59da6072e59c0 211 Gene3D G3DSA:3.40.50.2020 2 209 6.7E-75 T 09-03-2017 IPR029057 Phosphoribosyltransferase-like TK78_RS21560 2a37627f936d61eb52e1a65c04dc0b5f 438 SUPERFAMILY SSF48264 22 425 1.31E-102 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS21560 2a37627f936d61eb52e1a65c04dc0b5f 438 PRINTS PR00359 B-class P450 signature 363 372 5.4E-55 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS21560 2a37627f936d61eb52e1a65c04dc0b5f 438 PRINTS PR00359 B-class P450 signature 342 357 5.4E-55 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS21560 2a37627f936d61eb52e1a65c04dc0b5f 438 PRINTS PR00359 B-class P450 signature 372 383 5.4E-55 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS21560 2a37627f936d61eb52e1a65c04dc0b5f 438 PRINTS PR00359 B-class P450 signature 105 116 5.4E-55 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS21560 2a37627f936d61eb52e1a65c04dc0b5f 438 PRINTS PR00359 B-class P450 signature 151 167 5.4E-55 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS21560 2a37627f936d61eb52e1a65c04dc0b5f 438 PRINTS PR00359 B-class P450 signature 314 341 5.4E-55 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS21560 2a37627f936d61eb52e1a65c04dc0b5f 438 PRINTS PR00359 B-class P450 signature 168 183 5.4E-55 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS21560 2a37627f936d61eb52e1a65c04dc0b5f 438 PRINTS PR00359 B-class P450 signature 206 228 5.4E-55 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS21560 2a37627f936d61eb52e1a65c04dc0b5f 438 Pfam PF00067 Cytochrome P450 199 392 1.8E-22 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS21560 2a37627f936d61eb52e1a65c04dc0b5f 438 Gene3D G3DSA:1.10.630.10 19 426 5.8E-135 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS22875 fd732e8f2b612314ef9919f1216fd5b3 434 SUPERFAMILY SSF53335 335 396 1.86E-63 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS22875 fd732e8f2b612314ef9919f1216fd5b3 434 SUPERFAMILY SSF53335 9 70 1.86E-63 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS22875 fd732e8f2b612314ef9919f1216fd5b3 434 SUPERFAMILY SSF53335 100 299 1.86E-63 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS22875 fd732e8f2b612314ef9919f1216fd5b3 434 Pfam PF00145 C-5 cytosine-specific DNA methylase 10 392 9.7E-48 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS22875 fd732e8f2b612314ef9919f1216fd5b3 434 PRINTS PR00105 Cytosine-specific DNA methyltransferase signature 10 26 2.5E-10 T 09-03-2017 IPR001525 C-5 cytosine methyltransferase GO:0008168 KEGG: 00270+2.1.1.37 TK78_RS22875 fd732e8f2b612314ef9919f1216fd5b3 434 PRINTS PR00105 Cytosine-specific DNA methyltransferase signature 204 217 2.5E-10 T 09-03-2017 IPR001525 C-5 cytosine methyltransferase GO:0008168 KEGG: 00270+2.1.1.37 TK78_RS22875 fd732e8f2b612314ef9919f1216fd5b3 434 PRINTS PR00105 Cytosine-specific DNA methyltransferase signature 141 155 2.5E-10 T 09-03-2017 IPR001525 C-5 cytosine methyltransferase GO:0008168 KEGG: 00270+2.1.1.37 TK78_RS22875 fd732e8f2b612314ef9919f1216fd5b3 434 Gene3D G3DSA:3.90.120.10 215 383 2.5E-21 T 09-03-2017 TK78_RS22875 fd732e8f2b612314ef9919f1216fd5b3 434 Gene3D G3DSA:3.40.50.150 9 214 1.5E-42 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS22875 fd732e8f2b612314ef9919f1216fd5b3 434 TIGRFAM TIGR00675 dcm: DNA (cytosine-5-)-methyltransferase 12 392 1.3E-39 T 09-03-2017 IPR001525 C-5 cytosine methyltransferase GO:0008168 KEGG: 00270+2.1.1.37 TK78_RS22875 fd732e8f2b612314ef9919f1216fd5b3 434 ProSitePatterns PS00094 C-5 cytosine-specific DNA methylases active site. 103 115 - T 09-03-2017 IPR018117 DNA methylase, C-5 cytosine-specific, active site KEGG: 00270+2.1.1.37|Reactome: R-HSA-212300|Reactome: R-HSA-5334118 TK78_RS22875 fd732e8f2b612314ef9919f1216fd5b3 434 ProSitePatterns PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 374 392 - T 09-03-2017 IPR031303 DNA methylase, C-5 cytosine-specific, conserved site KEGG: 00270+2.1.1.37 TK78_RS04120 44865b5c62b030d5bd697b644164c26c 585 SUPERFAMILY SSF53474 18 232 4.05E-39 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04120 44865b5c62b030d5bd697b644164c26c 585 SUPERFAMILY SSF53474 273 367 4.05E-39 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04120 44865b5c62b030d5bd697b644164c26c 585 SUPERFAMILY SSF49785 395 583 4.04E-25 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS04120 44865b5c62b030d5bd697b644164c26c 585 Gene3D G3DSA:2.60.120.260 393 582 2.8E-27 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS04120 44865b5c62b030d5bd697b644164c26c 585 SMART SM00939 356 578 4.6E-13 T 09-03-2017 IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal GO:0008239 TK78_RS04120 44865b5c62b030d5bd697b644164c26c 585 Pfam PF02129 X-Pro dipeptidyl-peptidase (S15 family) 48 331 5.5E-23 T 09-03-2017 IPR000383 Xaa-Pro dipeptidyl-peptidase-like domain GO:0016787 TK78_RS04120 44865b5c62b030d5bd697b644164c26c 585 Pfam PF08530 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain 397 557 3.2E-10 T 09-03-2017 IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal GO:0008239 TK78_RS04120 44865b5c62b030d5bd697b644164c26c 585 Gene3D G3DSA:3.40.50.1820 27 197 2.5E-48 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04120 44865b5c62b030d5bd697b644164c26c 585 Gene3D G3DSA:3.40.50.1820 246 363 2.5E-48 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04120 44865b5c62b030d5bd697b644164c26c 585 TIGRFAM TIGR00976 /NonD: hydrolase CocE/NonD family protein 48 559 2.6E-26 T 09-03-2017 IPR005674 CocE/Serine esterase GO:0016787 TK78_RS15875 9b95bb33e8ac9c204f463523a4e63886 268 SUPERFAMILY SSF53474 10 265 1.35E-59 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS15875 9b95bb33e8ac9c204f463523a4e63886 268 Gene3D G3DSA:3.40.50.1820 9 265 9.5E-61 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS15875 9b95bb33e8ac9c204f463523a4e63886 268 Pfam PF00561 alpha/beta hydrolase fold 28 252 4.2E-22 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS15875 9b95bb33e8ac9c204f463523a4e63886 268 PRINTS PR00111 Alpha/beta hydrolase fold signature 53 68 8.3E-11 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS15875 9b95bb33e8ac9c204f463523a4e63886 268 PRINTS PR00111 Alpha/beta hydrolase fold signature 211 225 8.3E-11 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS15875 9b95bb33e8ac9c204f463523a4e63886 268 PRINTS PR00111 Alpha/beta hydrolase fold signature 97 110 8.3E-11 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS15875 9b95bb33e8ac9c204f463523a4e63886 268 PRINTS PR00111 Alpha/beta hydrolase fold signature 111 124 8.3E-11 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS04080 f3251ff07a03d921b4344c93e2f31f69 212 Pfam PF09335 SNARE associated Golgi protein 42 169 9.7E-15 T 09-03-2017 IPR032816 SNARE associated Golgi protein TK78_RS07975 ec66c5b20f4871d154408e0cde8eea8a 237 Gene3D G3DSA:3.20.20.190 7 228 3.3E-47 T 09-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 TK78_RS07975 ec66c5b20f4871d154408e0cde8eea8a 237 Pfam PF03009 Glycerophosphoryl diester phosphodiesterase family 13 223 7.0E-32 T 09-03-2017 IPR030395 Glycerophosphodiester phosphodiesterase domain GO:0006629|GO:0008081 TK78_RS07975 ec66c5b20f4871d154408e0cde8eea8a 237 SUPERFAMILY SSF51695 10 227 6.07E-49 T 09-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 TK78_RS01845 37b91819b2cf54b5c2d25c4cc281bed2 146 SUPERFAMILY SSF54427 21 139 5.86E-24 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS01845 37b91819b2cf54b5c2d25c4cc281bed2 146 Gene3D G3DSA:3.10.450.50 21 139 4.3E-21 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS01845 37b91819b2cf54b5c2d25c4cc281bed2 146 Pfam PF14534 Domain of unknown function (DUF4440) 27 132 1.1E-14 T 09-03-2017 IPR027843 Domain of unknown function DUF4440 TK78_RS27805 aa0fa83413188c8a712917545ec1854f 670 Gene3D G3DSA:2.60.60.30 64 161 1.3E-14 T 09-03-2017 TK78_RS27805 aa0fa83413188c8a712917545ec1854f 670 Pfam PF02342 TerD domain 63 162 2.1E-15 T 09-03-2017 IPR003325 TerD domain GO:0006950 TK78_RS13585 f1a4bef1dc9bb498285d96f683f1f41c 485 Pfam PF00561 alpha/beta hydrolase fold 88 456 8.4E-28 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS13585 f1a4bef1dc9bb498285d96f683f1f41c 485 Gene3D G3DSA:3.40.50.1820 53 138 8.5E-56 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS13585 f1a4bef1dc9bb498285d96f683f1f41c 485 Gene3D G3DSA:3.40.50.1820 350 470 8.5E-56 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS13585 f1a4bef1dc9bb498285d96f683f1f41c 485 Gene3D G3DSA:3.40.50.1820 183 306 8.5E-56 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS13585 f1a4bef1dc9bb498285d96f683f1f41c 485 SUPERFAMILY SSF53474 83 139 3.77E-23 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS13585 f1a4bef1dc9bb498285d96f683f1f41c 485 SUPERFAMILY SSF53474 372 470 3.77E-23 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS13585 f1a4bef1dc9bb498285d96f683f1f41c 485 SUPERFAMILY SSF53474 185 299 3.77E-23 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS16005 e2ffb06620f3d68f5f6ab5a9c6fd59a2 298 Pfam PF06240 Carbon monoxide dehydrogenase subunit G (CoxG) 7 139 3.8E-8 T 09-03-2017 IPR010419 Carbon monoxide dehydrogenase subunit G TK78_RS16005 e2ffb06620f3d68f5f6ab5a9c6fd59a2 298 SUPERFAMILY SSF55961 1 138 3.12E-17 T 09-03-2017 TK78_RS16005 e2ffb06620f3d68f5f6ab5a9c6fd59a2 298 Gene3D G3DSA:3.30.530.20 1 138 3.4E-21 T 09-03-2017 IPR023393 START-like domain TK78_RS34075 df68ad7bb21ce22224022c2ca4675486 369 Pfam PF03060 Nitronate monooxygenase 17 351 8.7E-50 T 09-03-2017 IPR004136 Nitronate monooxygenase GO:0018580|GO:0055114 KEGG: 00910+1.13.12.16|MetaCyc: PWY-723 TK78_RS34075 df68ad7bb21ce22224022c2ca4675486 369 Gene3D G3DSA:3.20.20.70 106 346 5.4E-55 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS34075 df68ad7bb21ce22224022c2ca4675486 369 Gene3D G3DSA:3.20.20.70 1 71 5.4E-55 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS34075 df68ad7bb21ce22224022c2ca4675486 369 SUPERFAMILY SSF51412 2 358 3.82E-43 T 09-03-2017 TK78_RS18650 35dee7487f629886bc00ff084a969fef 333 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 111 324 2.8E-12 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS18650 35dee7487f629886bc00ff084a969fef 333 TIGRFAM TIGR02138 phosphate_pstC: phosphate ABC transporter, permease protein PstC 31 325 4.5E-88 T 09-03-2017 IPR011864 Phosphate ABC transporter, permease protein PstC GO:0005315|GO:0006817|GO:0016021 TK78_RS18650 35dee7487f629886bc00ff084a969fef 333 SUPERFAMILY SSF161098 53 317 1.28E-31 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS18650 35dee7487f629886bc00ff084a969fef 333 Gene3D G3DSA:1.10.3720.10 43 328 1.5E-35 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS28180 cd0866d2381da53f6cd51d5932fe4c6c 132 Gene3D G3DSA:2.60.120.10 36 112 2.2E-11 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS28180 cd0866d2381da53f6cd51d5932fe4c6c 132 SUPERFAMILY SSF51182 3 127 6.37E-20 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS28180 cd0866d2381da53f6cd51d5932fe4c6c 132 ProDom PD080544 SYNTHASE 4.2.1.- LYASE L-ECTOINE DEHYDRATASE N-ACETYLDIAMINOBUTYRATE ECTOINE ENZYME SYNTHASE:ECTOINE ECTC 1 119 2.0E-65 T 09-03-2017 IPR010462 Ectoine synthase GO:0019491|GO:0033990 KEGG: 00260+4.2.1.108|KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 TK78_RS28180 cd0866d2381da53f6cd51d5932fe4c6c 132 Pfam PF06339 Ectoine synthase 2 127 8.6E-56 T 09-03-2017 IPR010462 Ectoine synthase GO:0019491|GO:0033990 KEGG: 00260+4.2.1.108|KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 TK78_RS28180 cd0866d2381da53f6cd51d5932fe4c6c 132 Hamap MF_01255 L-ectoine synthase [ectC]. 1 129 38.05 T 09-03-2017 IPR010462 Ectoine synthase GO:0019491|GO:0033990 KEGG: 00260+4.2.1.108|KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 TK78_RS05820 ff94b55a8c8c8ebe4c690e6aec148a5d 466 Pfam PF02875 Mur ligase family, glutamate ligase domain 317 403 8.7E-21 T 09-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TK78_RS05820 ff94b55a8c8c8ebe4c690e6aec148a5d 466 Gene3D G3DSA:3.40.1190.10 99 318 9.1E-73 T 09-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 TK78_RS05820 ff94b55a8c8c8ebe4c690e6aec148a5d 466 SUPERFAMILY SSF53244 316 462 4.03E-42 T 09-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TK78_RS05820 ff94b55a8c8c8ebe4c690e6aec148a5d 466 Gene3D G3DSA:3.40.50.720 11 98 2.7E-33 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS05820 ff94b55a8c8c8ebe4c690e6aec148a5d 466 SUPERFAMILY SSF51984 10 98 2.88E-25 T 09-03-2017 TK78_RS05820 ff94b55a8c8c8ebe4c690e6aec148a5d 466 Gene3D G3DSA:3.90.190.20 319 463 3.1E-49 T 09-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TK78_RS05820 ff94b55a8c8c8ebe4c690e6aec148a5d 466 TIGRFAM TIGR01082 murC: UDP-N-acetylmuramate--L-alanine ligase 13 457 3.0E-138 T 09-03-2017 IPR005758 UDP-N-acetylmuramate--L-alanine ligase GO:0008763|GO:0009252 KEGG: 00471+6.3.2.8|KEGG: 00550+6.3.2.8|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS05820 ff94b55a8c8c8ebe4c690e6aec148a5d 466 Hamap MF_00046 UDP-N-acetylmuramate--L-alanine ligase [murC]. 9 464 38.354 T 09-03-2017 IPR005758 UDP-N-acetylmuramate--L-alanine ligase GO:0008763|GO:0009252 KEGG: 00471+6.3.2.8|KEGG: 00550+6.3.2.8|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS05820 ff94b55a8c8c8ebe4c690e6aec148a5d 466 Pfam PF01225 Mur ligase family, catalytic domain 13 109 5.5E-27 T 09-03-2017 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 TK78_RS05820 ff94b55a8c8c8ebe4c690e6aec148a5d 466 Pfam PF08245 Mur ligase middle domain 115 296 1.9E-23 T 09-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 TK78_RS05820 ff94b55a8c8c8ebe4c690e6aec148a5d 466 SUPERFAMILY SSF53623 96 314 3.92E-56 T 09-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 TK78_RS23010 e590768cca89865fcac0567a07637f81 241 Gene3D G3DSA:2.40.260.10 74 207 1.6E-7 T 09-03-2017 IPR023365 Sortase domain TK78_RS23010 e590768cca89865fcac0567a07637f81 241 Pfam PF04203 Sortase family 74 216 3.8E-16 T 09-03-2017 IPR005754 Sortase family TK78_RS23010 e590768cca89865fcac0567a07637f81 241 SUPERFAMILY SSF63817 65 205 2.55E-15 T 09-03-2017 IPR023365 Sortase domain TK78_RS18435 a0e2f418c226565179144ad0ba22fcb7 315 SUPERFAMILY SSF51430 6 313 1.09E-82 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS18435 a0e2f418c226565179144ad0ba22fcb7 315 Pfam PF00248 Aldo/keto reductase family 17 313 1.7E-61 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS18435 a0e2f418c226565179144ad0ba22fcb7 315 Gene3D G3DSA:3.20.20.100 11 313 4.1E-81 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS30195 0de28a4736180bf75ec2738d8a4a56c5 289 ProSitePatterns PS00211 ABC transporters family signature. 136 150 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS30195 0de28a4736180bf75ec2738d8a4a56c5 289 SUPERFAMILY SSF52540 6 232 6.61E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS30195 0de28a4736180bf75ec2738d8a4a56c5 289 Pfam PF00005 ABC transporter 25 163 5.4E-25 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS30195 0de28a4736180bf75ec2738d8a4a56c5 289 SMART SM00382 34 212 1.6E-8 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS30195 0de28a4736180bf75ec2738d8a4a56c5 289 Gene3D G3DSA:3.40.50.300 5 233 9.5E-65 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS20345 cebee317fbbcbbdb80004000769c84af 279 Pfam PF01575 MaoC like domain 184 252 8.1E-13 T 09-03-2017 IPR002539 MaoC-like domain TK78_RS20345 cebee317fbbcbbdb80004000769c84af 279 Gene3D G3DSA:3.10.129.10 172 276 2.7E-22 T 09-03-2017 IPR029069 HotDog domain TK78_RS20345 cebee317fbbcbbdb80004000769c84af 279 SUPERFAMILY SSF54637 170 273 5.02E-21 T 09-03-2017 IPR029069 HotDog domain TK78_RS20345 cebee317fbbcbbdb80004000769c84af 279 SUPERFAMILY SSF54637 64 143 6.65E-5 T 09-03-2017 IPR029069 HotDog domain TK78_RS19695 8e030f5043a49d17ca173cc8eb0be58d 224 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 46 208 7.5E-24 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS19695 8e030f5043a49d17ca173cc8eb0be58d 224 Gene3D G3DSA:1.10.3720.10 20 211 1.2E-29 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS19695 8e030f5043a49d17ca173cc8eb0be58d 224 SUPERFAMILY SSF161098 21 203 6.02E-37 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS28185 909500a12441e8c6be035e688d128abb 420 Gene3D G3DSA:3.40.640.10 65 317 1.6E-60 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS28185 909500a12441e8c6be035e688d128abb 420 Gene3D G3DSA:3.90.1150.10 324 418 2.0E-32 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS28185 909500a12441e8c6be035e688d128abb 420 Gene3D G3DSA:3.90.1150.10 21 61 2.0E-32 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS28185 909500a12441e8c6be035e688d128abb 420 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 239 275 - T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS28185 909500a12441e8c6be035e688d128abb 420 SUPERFAMILY SSF53383 15 417 1.85E-106 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS28185 909500a12441e8c6be035e688d128abb 420 TIGRFAM TIGR00709 dat: 2,4-diaminobutyrate 4-transaminase 8 418 3.9E-138 T 09-03-2017 IPR004637 2,4-diaminobutyrate 4-transaminase GO:0008483|GO:0009058 KEGG: 00260+2.6.1.76|MetaCyc: PWY-6409|MetaCyc: PWY-6562|MetaCyc: PWY-761 TK78_RS28185 909500a12441e8c6be035e688d128abb 420 Pfam PF00202 Aminotransferase class-III 27 415 3.8E-75 T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS28185 909500a12441e8c6be035e688d128abb 420 TIGRFAM TIGR02407 ectoine_ectB: diaminobutyrate--2-oxoglutarate aminotransferase 10 417 1.4E-200 T 09-03-2017 IPR012773 Ectoine biosynthetic protein GO:0019491|GO:0030170|GO:0047307 KEGG: 00260+2.6.1.76|MetaCyc: PWY-6409|MetaCyc: PWY-6562|MetaCyc: PWY-761 TK78_RS22395 ed22af2501245ee25821d44b29e67366 298 Gene3D G3DSA:1.10.3720.10 26 286 3.5E-65 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS22395 ed22af2501245ee25821d44b29e67366 298 SUPERFAMILY SSF161098 26 292 2.24E-68 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS22395 ed22af2501245ee25821d44b29e67366 298 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 108 289 4.5E-20 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS22110 6049fbd36076dbe96d85c71cb27ee221 251 Pfam PF00072 Response regulator receiver domain 37 148 1.4E-27 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS22110 6049fbd36076dbe96d85c71cb27ee221 251 SUPERFAMILY SSF46894 171 248 3.74E-24 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS22110 6049fbd36076dbe96d85c71cb27ee221 251 SMART SM00448 35 148 5.3E-33 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS22110 6049fbd36076dbe96d85c71cb27ee221 251 Pfam PF00196 Bacterial regulatory proteins, luxR family 187 242 4.6E-23 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS22110 6049fbd36076dbe96d85c71cb27ee221 251 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 202 218 8.1E-16 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS22110 6049fbd36076dbe96d85c71cb27ee221 251 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 188 202 8.1E-16 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS22110 6049fbd36076dbe96d85c71cb27ee221 251 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 218 230 8.1E-16 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS22110 6049fbd36076dbe96d85c71cb27ee221 251 ProSitePatterns PS00622 LuxR-type HTH domain signature. 202 229 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS22110 6049fbd36076dbe96d85c71cb27ee221 251 SUPERFAMILY SSF52172 34 166 3.7E-36 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS22110 6049fbd36076dbe96d85c71cb27ee221 251 SMART SM00421 185 242 3.2E-28 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS22110 6049fbd36076dbe96d85c71cb27ee221 251 Gene3D G3DSA:1.10.10.10 155 249 8.9E-34 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS22110 6049fbd36076dbe96d85c71cb27ee221 251 Gene3D G3DSA:3.40.50.2300 31 154 4.6E-38 T 09-03-2017 TK78_RS32025 cdef18ff712f1f241854c8666348ce88 751 ProSitePatterns PS00436 Peroxidases active site signature. 113 124 - T 09-03-2017 IPR019794 Peroxidase, active site GO:0004601|GO:0055114 TK78_RS32025 cdef18ff712f1f241854c8666348ce88 751 SUPERFAMILY SSF48113 42 448 4.72E-153 T 09-03-2017 IPR010255 Haem peroxidase GO:0004601|GO:0006979|GO:0020037|GO:0055114 TK78_RS32025 cdef18ff712f1f241854c8666348ce88 751 ProSitePatterns PS00435 Peroxidases proximal heme-ligand signature. 277 287 - T 09-03-2017 IPR019793 Peroxidases heam-ligand binding site Reactome: R-HSA-2408557 TK78_RS32025 cdef18ff712f1f241854c8666348ce88 751 TIGRFAM TIGR00198 cat_per_HPI: catalase/peroxidase HPI 45 751 0.0 T 09-03-2017 IPR000763 Catalase-peroxidase haem GO:0004096|GO:0004601|GO:0006979|GO:0020037|GO:0055114 KEGG: 00360+1.11.1.21|KEGG: 00380+1.11.1.21|KEGG: 00940+1.11.1.21|MetaCyc: PWY-5506 TK78_RS32025 cdef18ff712f1f241854c8666348ce88 751 PRINTS PR00460 Bacterial haem catalase-peroxidase signature 75 88 1.6E-50 T 09-03-2017 IPR000763 Catalase-peroxidase haem GO:0004096|GO:0004601|GO:0006979|GO:0020037|GO:0055114 KEGG: 00360+1.11.1.21|KEGG: 00380+1.11.1.21|KEGG: 00940+1.11.1.21|MetaCyc: PWY-5506 TK78_RS32025 cdef18ff712f1f241854c8666348ce88 751 PRINTS PR00460 Bacterial haem catalase-peroxidase signature 49 71 1.6E-50 T 09-03-2017 IPR000763 Catalase-peroxidase haem GO:0004096|GO:0004601|GO:0006979|GO:0020037|GO:0055114 KEGG: 00360+1.11.1.21|KEGG: 00380+1.11.1.21|KEGG: 00940+1.11.1.21|MetaCyc: PWY-5506 TK78_RS32025 cdef18ff712f1f241854c8666348ce88 751 PRINTS PR00460 Bacterial haem catalase-peroxidase signature 285 308 1.6E-50 T 09-03-2017 IPR000763 Catalase-peroxidase haem GO:0004096|GO:0004601|GO:0006979|GO:0020037|GO:0055114 KEGG: 00360+1.11.1.21|KEGG: 00380+1.11.1.21|KEGG: 00940+1.11.1.21|MetaCyc: PWY-5506 TK78_RS32025 cdef18ff712f1f241854c8666348ce88 751 PRINTS PR00460 Bacterial haem catalase-peroxidase signature 90 115 1.6E-50 T 09-03-2017 IPR000763 Catalase-peroxidase haem GO:0004096|GO:0004601|GO:0006979|GO:0020037|GO:0055114 KEGG: 00360+1.11.1.21|KEGG: 00380+1.11.1.21|KEGG: 00940+1.11.1.21|MetaCyc: PWY-5506 TK78_RS32025 cdef18ff712f1f241854c8666348ce88 751 PRINTS PR00460 Bacterial haem catalase-peroxidase signature 498 524 1.6E-50 T 09-03-2017 IPR000763 Catalase-peroxidase haem GO:0004096|GO:0004601|GO:0006979|GO:0020037|GO:0055114 KEGG: 00360+1.11.1.21|KEGG: 00380+1.11.1.21|KEGG: 00940+1.11.1.21|MetaCyc: PWY-5506 TK78_RS32025 cdef18ff712f1f241854c8666348ce88 751 PRINTS PR00458 Haem peroxidase superfamily signature 191 203 1.5E-19 T 09-03-2017 IPR002016 Haem peroxidase, plant/fungal/bacterial GO:0004601|GO:0006979|GO:0020037|GO:0055114 TK78_RS32025 cdef18ff712f1f241854c8666348ce88 751 PRINTS PR00458 Haem peroxidase superfamily signature 173 190 1.5E-19 T 09-03-2017 IPR002016 Haem peroxidase, plant/fungal/bacterial GO:0004601|GO:0006979|GO:0020037|GO:0055114 TK78_RS32025 cdef18ff712f1f241854c8666348ce88 751 PRINTS PR00458 Haem peroxidase superfamily signature 113 127 1.5E-19 T 09-03-2017 IPR002016 Haem peroxidase, plant/fungal/bacterial GO:0004601|GO:0006979|GO:0020037|GO:0055114 TK78_RS32025 cdef18ff712f1f241854c8666348ce88 751 PRINTS PR00458 Haem peroxidase superfamily signature 277 292 1.5E-19 T 09-03-2017 IPR002016 Haem peroxidase, plant/fungal/bacterial GO:0004601|GO:0006979|GO:0020037|GO:0055114 TK78_RS32025 cdef18ff712f1f241854c8666348ce88 751 PRINTS PR00458 Haem peroxidase superfamily signature 336 351 1.5E-19 T 09-03-2017 IPR002016 Haem peroxidase, plant/fungal/bacterial GO:0004601|GO:0006979|GO:0020037|GO:0055114 TK78_RS32025 cdef18ff712f1f241854c8666348ce88 751 Gene3D G3DSA:1.10.420.10 270 292 9.4E-46 T 09-03-2017 TK78_RS32025 cdef18ff712f1f241854c8666348ce88 751 Gene3D G3DSA:1.10.420.10 328 425 9.4E-46 T 09-03-2017 TK78_RS32025 cdef18ff712f1f241854c8666348ce88 751 Gene3D G3DSA:1.10.420.10 605 726 1.5E-43 T 09-03-2017 TK78_RS32025 cdef18ff712f1f241854c8666348ce88 751 SUPERFAMILY SSF48113 448 750 5.6E-107 T 09-03-2017 IPR010255 Haem peroxidase GO:0004601|GO:0006979|GO:0020037|GO:0055114 TK78_RS32025 cdef18ff712f1f241854c8666348ce88 751 Hamap MF_01961 Catalase-peroxidase [katG]. 28 751 41.918 T 09-03-2017 IPR000763 Catalase-peroxidase haem GO:0004096|GO:0004601|GO:0006979|GO:0020037|GO:0055114 KEGG: 00360+1.11.1.21|KEGG: 00380+1.11.1.21|KEGG: 00940+1.11.1.21|MetaCyc: PWY-5506 TK78_RS32025 cdef18ff712f1f241854c8666348ce88 751 Gene3D G3DSA:1.10.520.10 257 269 3.8E-71 T 09-03-2017 TK78_RS32025 cdef18ff712f1f241854c8666348ce88 751 Gene3D G3DSA:1.10.520.10 450 604 4.6E-58 T 09-03-2017 TK78_RS32025 cdef18ff712f1f241854c8666348ce88 751 Gene3D G3DSA:1.10.520.10 70 224 3.8E-71 T 09-03-2017 TK78_RS32025 cdef18ff712f1f241854c8666348ce88 751 Gene3D G3DSA:1.10.520.10 729 750 4.6E-58 T 09-03-2017 TK78_RS32025 cdef18ff712f1f241854c8666348ce88 751 Pfam PF00141 Peroxidase 420 725 2.2E-38 T 09-03-2017 IPR002016 Haem peroxidase, plant/fungal/bacterial GO:0004601|GO:0006979|GO:0020037|GO:0055114 TK78_RS32025 cdef18ff712f1f241854c8666348ce88 751 Pfam PF00141 Peroxidase 105 413 7.6E-49 T 09-03-2017 IPR002016 Haem peroxidase, plant/fungal/bacterial GO:0004601|GO:0006979|GO:0020037|GO:0055114 TK78_RS04880 a8d7f5c2d8360622112db6cda4472b75 447 Pfam PF01979 Amidohydrolase family 56 408 1.7E-26 T 09-03-2017 IPR006680 Amidohydrolase-related GO:0016787 TK78_RS04880 a8d7f5c2d8360622112db6cda4472b75 447 Gene3D G3DSA:3.20.20.140 74 396 3.9E-128 T 09-03-2017 TK78_RS04880 a8d7f5c2d8360622112db6cda4472b75 447 Gene3D G3DSA:2.30.40.10 8 73 7.4E-14 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS04880 a8d7f5c2d8360622112db6cda4472b75 447 TIGRFAM TIGR03178 allantoinase: allantoinase 8 445 7.6E-186 T 09-03-2017 IPR017593 Allantoinase GO:0000256|GO:0004038|GO:0008270|GO:0050897 KEGG: 00230+3.5.2.5|MetaCyc: PWY-5697|MetaCyc: PWY-5698 TK78_RS04880 a8d7f5c2d8360622112db6cda4472b75 447 SUPERFAMILY SSF51556 60 375 6.39E-98 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS04880 a8d7f5c2d8360622112db6cda4472b75 447 SUPERFAMILY SSF51338 7 59 1.85E-19 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS04880 a8d7f5c2d8360622112db6cda4472b75 447 SUPERFAMILY SSF51338 375 436 1.85E-19 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS34275 e25c3b1e27de8b51d26faaa53fe71c4f 144 SUPERFAMILY SSF52799 52 142 9.48E-17 T 09-03-2017 IPR029021 Protein-tyrosine phosphatase-like TK78_RS34275 e25c3b1e27de8b51d26faaa53fe71c4f 144 Pfam PF00102 Protein-tyrosine phosphatase 53 118 3.3E-5 T 09-03-2017 IPR000242 PTP type protein phosphatase GO:0004725|GO:0006470 TK78_RS34275 e25c3b1e27de8b51d26faaa53fe71c4f 144 Gene3D G3DSA:3.90.190.10 56 142 1.1E-16 T 09-03-2017 IPR029021 Protein-tyrosine phosphatase-like TK78_RS28735 fc9383a9cfd1632853d53dcb47d0ff5e 218 SUPERFAMILY SSF69593 22 207 2.62E-28 T 09-03-2017 TK78_RS28735 fc9383a9cfd1632853d53dcb47d0ff5e 218 SMART SM00563 44 154 1.3E-22 T 09-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 TK78_RS28735 fc9383a9cfd1632853d53dcb47d0ff5e 218 Gene3D G3DSA:3.40.1130.10 36 158 7.1E-14 T 09-03-2017 TK78_RS28735 fc9383a9cfd1632853d53dcb47d0ff5e 218 Pfam PF01553 Acyltransferase 33 151 6.4E-17 T 09-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 TK78_RS24765 449effcad6f11d479dca68e5cb79278d 338 Pfam PF01628 HrcA protein C terminal domain 103 321 1.2E-62 T 09-03-2017 IPR021153 Heat-inducible transcription repressor HrcA, C-terminal GO:0003677|GO:0006355 TK78_RS24765 449effcad6f11d479dca68e5cb79278d 338 Gene3D G3DSA:1.10.10.10 1 84 8.6E-36 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS24765 449effcad6f11d479dca68e5cb79278d 338 TIGRFAM TIGR00331 hrcA: heat-inducible transcription repressor HrcA 3 334 3.8E-102 T 09-03-2017 IPR002571 Heat-inducible transcription repressor HrcA GO:0003677|GO:0006355 TK78_RS24765 449effcad6f11d479dca68e5cb79278d 338 SUPERFAMILY SSF55781 71 336 1.28E-58 T 09-03-2017 IPR029016 GAF domain-like TK78_RS24765 449effcad6f11d479dca68e5cb79278d 338 Gene3D G3DSA:3.30.450.40 176 337 1.8E-44 T 09-03-2017 IPR029016 GAF domain-like TK78_RS24765 449effcad6f11d479dca68e5cb79278d 338 PIRSF PIRSF005485 1 338 5.1E-102 T 09-03-2017 IPR002571 Heat-inducible transcription repressor HrcA GO:0003677|GO:0006355 TK78_RS24765 449effcad6f11d479dca68e5cb79278d 338 SUPERFAMILY SSF46785 1 82 7.01E-24 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS24765 449effcad6f11d479dca68e5cb79278d 338 Hamap MF_00081 Heat-inducible transcription repressor HrcA [hrcA]. 1 328 28.676 T 09-03-2017 IPR002571 Heat-inducible transcription repressor HrcA GO:0003677|GO:0006355 TK78_RS23925 325518b656ae754fb3b690bbbeb517be 308 SUPERFAMILY SSF51658 11 301 2.9E-49 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS23925 325518b656ae754fb3b690bbbeb517be 308 Pfam PF01261 Xylose isomerase-like TIM barrel 37 239 5.9E-28 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS23925 325518b656ae754fb3b690bbbeb517be 308 Gene3D G3DSA:3.20.20.150 9 302 4.2E-66 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS27970 7abca8cc48009fb78f8c4b6722901bff 313 SMART SM00382 31 217 3.8E-13 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS27970 7abca8cc48009fb78f8c4b6722901bff 313 Gene3D G3DSA:3.40.50.300 2 221 4.6E-61 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27970 7abca8cc48009fb78f8c4b6722901bff 313 SUPERFAMILY SSF52540 4 221 7.07E-56 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27970 7abca8cc48009fb78f8c4b6722901bff 313 Pfam PF00005 ABC transporter 23 161 2.0E-22 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS27970 7abca8cc48009fb78f8c4b6722901bff 313 ProSitePatterns PS00211 ABC transporters family signature. 133 147 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS12240 3ad0d3759c8db216528d9b694689c5a4 453 SUPERFAMILY SSF48452 104 176 2.36E-6 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS12240 3ad0d3759c8db216528d9b694689c5a4 453 Gene3D G3DSA:1.25.40.10 102 178 2.8E-6 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS10425 b0bff452207dbebea62265b37120e5a1 320 Pfam PF01820 D-ala D-ala ligase N-terminus 11 91 9.7E-20 T 09-03-2017 IPR011127 D-alanine--D-alanine ligase, N-terminal domain KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS10425 b0bff452207dbebea62265b37120e5a1 320 PIRSF PIRSF039102 47 318 1.4E-67 T 09-03-2017 IPR005905 D-alanine--D-alanine ligase GO:0005737|GO:0008716 KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS10425 b0bff452207dbebea62265b37120e5a1 320 ProSitePatterns PS00843 D-alanine--D-alanine ligase signature 1. 68 79 - T 09-03-2017 IPR000291 D-alanine--D-alanine ligase/VANA/B/C, conserved site KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS10425 b0bff452207dbebea62265b37120e5a1 320 Pfam PF07478 D-ala D-ala ligase C-terminus 108 309 3.0E-39 T 09-03-2017 IPR011095 D-alanine--D-alanine ligase, C-terminal GO:0008716 KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS10425 b0bff452207dbebea62265b37120e5a1 320 SUPERFAMILY SSF56059 102 308 6.01E-41 T 09-03-2017 TK78_RS10425 b0bff452207dbebea62265b37120e5a1 320 SUPERFAMILY SSF52440 11 100 2.69E-24 T 09-03-2017 IPR016185 Pre-ATP-grasp domain TK78_RS10425 b0bff452207dbebea62265b37120e5a1 320 Gene3D G3DSA:3.40.50.20 9 89 2.4E-23 T 09-03-2017 IPR016185 Pre-ATP-grasp domain TK78_RS10425 b0bff452207dbebea62265b37120e5a1 320 Gene3D G3DSA:3.30.1490.20 101 183 4.7E-13 T 09-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 TK78_RS10425 b0bff452207dbebea62265b37120e5a1 320 Hamap MF_00047 D-alanine--D-alanine ligase [ddl]. 9 313 29.111 T 09-03-2017 IPR005905 D-alanine--D-alanine ligase GO:0005737|GO:0008716 KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS10425 b0bff452207dbebea62265b37120e5a1 320 ProSitePatterns PS00844 D-alanine--D-alanine ligase signature 2. 255 283 - T 09-03-2017 IPR000291 D-alanine--D-alanine ligase/VANA/B/C, conserved site KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS10425 b0bff452207dbebea62265b37120e5a1 320 Gene3D G3DSA:3.30.470.20 184 312 1.9E-37 T 09-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 TK78_RS10425 b0bff452207dbebea62265b37120e5a1 320 Gene3D G3DSA:3.30.470.20 90 100 1.9E-37 T 09-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 TK78_RS17385 8dc279db6204730645ee96247a598c95 376 SUPERFAMILY SSF52540 252 350 1.13E-40 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17385 8dc279db6204730645ee96247a598c95 376 SUPERFAMILY SSF52540 1 223 1.13E-40 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17385 8dc279db6204730645ee96247a598c95 376 ProSitePatterns PS00618 RecF protein signature 2. 319 337 - T 09-03-2017 IPR018078 DNA-binding, RecF, conserved site GO:0003697|GO:0005524|GO:0006281 TK78_RS17385 8dc279db6204730645ee96247a598c95 376 Gene3D G3DSA:3.40.50.300 1 166 9.8E-53 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17385 8dc279db6204730645ee96247a598c95 376 Gene3D G3DSA:3.40.50.300 247 350 9.8E-53 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17385 8dc279db6204730645ee96247a598c95 376 Hamap MF_00365 DNA replication and repair protein RecF [recF]. 1 376 97.217 T 09-03-2017 IPR001238 DNA-binding, RecF GO:0003697|GO:0005524|GO:0006281 TK78_RS17385 8dc279db6204730645ee96247a598c95 376 Pfam PF02463 RecF/RecN/SMC N terminal domain 3 351 1.4E-18 T 09-03-2017 IPR003395 RecF/RecN/SMC, N-terminal TK78_RS17385 8dc279db6204730645ee96247a598c95 376 TIGRFAM TIGR00611 recf: DNA replication and repair protein RecF 1 364 2.8E-124 T 09-03-2017 IPR001238 DNA-binding, RecF GO:0003697|GO:0005524|GO:0006281 TK78_RS17385 8dc279db6204730645ee96247a598c95 376 ProSitePatterns PS00617 RecF protein signature 1. 117 137 - T 09-03-2017 IPR018078 DNA-binding, RecF, conserved site GO:0003697|GO:0005524|GO:0006281 TK78_RS05145 6cddb4b9b05313809674e2ba0ffda040 125 Pfam PF12840 Helix-turn-helix domain 4 60 1.1E-13 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05145 6cddb4b9b05313809674e2ba0ffda040 125 SUPERFAMILY SSF46785 4 82 2.85E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05145 6cddb4b9b05313809674e2ba0ffda040 125 SMART SM00418 2 83 2.6E-19 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS05145 6cddb4b9b05313809674e2ba0ffda040 125 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 51 66 1.6E-11 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS05145 6cddb4b9b05313809674e2ba0ffda040 125 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 36 51 1.6E-11 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS05145 6cddb4b9b05313809674e2ba0ffda040 125 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 4 19 1.6E-11 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS05145 6cddb4b9b05313809674e2ba0ffda040 125 Gene3D G3DSA:1.10.10.10 4 84 1.0E-25 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS23015 f2df2879d9c396faa432cf573542148c 348 SUPERFAMILY SSF51989 52 344 3.4E-87 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS23015 f2df2879d9c396faa432cf573542148c 348 Pfam PF01341 Glycosyl hydrolases family 6 69 329 1.6E-81 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS23015 f2df2879d9c396faa432cf573542148c 348 Gene3D G3DSA:3.20.20.40 60 344 1.6E-95 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS23015 f2df2879d9c396faa432cf573542148c 348 PIRSF PIRSF001100 8 348 5.8E-90 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS23015 f2df2879d9c396faa432cf573542148c 348 PRINTS PR00733 Glycosyl hydrolase family 6 signature 121 134 2.0E-39 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS23015 f2df2879d9c396faa432cf573542148c 348 PRINTS PR00733 Glycosyl hydrolase family 6 signature 81 100 2.0E-39 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS23015 f2df2879d9c396faa432cf573542148c 348 PRINTS PR00733 Glycosyl hydrolase family 6 signature 236 246 2.0E-39 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS23015 f2df2879d9c396faa432cf573542148c 348 PRINTS PR00733 Glycosyl hydrolase family 6 signature 206 219 2.0E-39 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS23015 f2df2879d9c396faa432cf573542148c 348 PRINTS PR00733 Glycosyl hydrolase family 6 signature 310 324 2.0E-39 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS23015 f2df2879d9c396faa432cf573542148c 348 PRINTS PR00733 Glycosyl hydrolase family 6 signature 286 306 2.0E-39 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS23015 f2df2879d9c396faa432cf573542148c 348 PRINTS PR00733 Glycosyl hydrolase family 6 signature 266 279 2.0E-39 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS23015 f2df2879d9c396faa432cf573542148c 348 PRINTS PR00733 Glycosyl hydrolase family 6 signature 149 164 2.0E-39 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS00850 d9bbc451d254d9ad5aca20efa7d8b1ee 336 Gene3D G3DSA:3.20.20.100 10 323 1.8E-55 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS00850 d9bbc451d254d9ad5aca20efa7d8b1ee 336 SUPERFAMILY SSF51430 9 323 8.12E-62 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS00850 d9bbc451d254d9ad5aca20efa7d8b1ee 336 Pfam PF00248 Aldo/keto reductase family 10 323 3.3E-51 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS31680 2a92fd82127b5b8e113da1ea598aa6fc 224 SUPERFAMILY SSF48498 89 209 6.45E-15 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS31680 2a92fd82127b5b8e113da1ea598aa6fc 224 SUPERFAMILY SSF46689 10 86 5.64E-18 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS31680 2a92fd82127b5b8e113da1ea598aa6fc 224 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 41 64 5.1E-6 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS31680 2a92fd82127b5b8e113da1ea598aa6fc 224 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 21 34 5.1E-6 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS31680 2a92fd82127b5b8e113da1ea598aa6fc 224 Pfam PF00440 Bacterial regulatory proteins, tetR family 21 66 4.1E-11 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS31680 2a92fd82127b5b8e113da1ea598aa6fc 224 ProSitePatterns PS01081 TetR-type HTH domain signature. 33 62 - T 09-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site TK78_RS31680 2a92fd82127b5b8e113da1ea598aa6fc 224 Gene3D G3DSA:1.10.357.10 1 209 2.0E-46 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS30985 ee97996949ce12aa879f3747460a9b7c 312 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 8 19 6.5E-8 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS30985 ee97996949ce12aa879f3747460a9b7c 312 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 19 32 6.5E-8 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS30985 ee97996949ce12aa879f3747460a9b7c 312 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 43 63 6.5E-8 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS30985 ee97996949ce12aa879f3747460a9b7c 312 Gene3D G3DSA:1.10.1660.10 7 123 1.0E-25 T 09-03-2017 TK78_RS30985 ee97996949ce12aa879f3747460a9b7c 312 Pfam PF13411 MerR HTH family regulatory protein 7 75 2.6E-16 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS30985 ee97996949ce12aa879f3747460a9b7c 312 SMART SM00422 7 76 1.9E-21 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS30985 ee97996949ce12aa879f3747460a9b7c 312 SUPERFAMILY SSF46955 7 117 1.83E-23 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS20865 f2d604f19b73be4aea68cea36cbd73ea 272 Gene3D G3DSA:3.40.50.1580 1 264 1.5E-85 T 09-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 TK78_RS20865 f2d604f19b73be4aea68cea36cbd73ea 272 SUPERFAMILY SSF53167 1 264 4.45E-82 T 09-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 TK78_RS20865 f2d604f19b73be4aea68cea36cbd73ea 272 TIGRFAM TIGR01694 MTAP: methylthioadenosine phosphorylase 1 246 2.6E-87 T 09-03-2017 IPR010044 Methylthioadenosine phosphorylase (MTAP) GO:0017061 Reactome: R-HSA-1237112 TK78_RS20865 f2d604f19b73be4aea68cea36cbd73ea 272 Pfam PF01048 Phosphorylase superfamily 1 244 1.9E-42 T 09-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 TK78_RS20865 f2d604f19b73be4aea68cea36cbd73ea 272 Hamap MF_01963 S-methyl-5'-thioadenosine phosphorylase [mtnP]. 1 267 40.564 T 09-03-2017 IPR010044 Methylthioadenosine phosphorylase (MTAP) GO:0017061 Reactome: R-HSA-1237112 TK78_RS31805 ff1539aecf795b2f5260c7d98e4adbd0 402 Gene3D G3DSA:3.20.20.30 301 370 1.9E-100 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS31805 ff1539aecf795b2f5260c7d98e4adbd0 402 Gene3D G3DSA:3.20.20.30 35 267 1.9E-100 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS31805 ff1539aecf795b2f5260c7d98e4adbd0 402 Pfam PF00296 Luciferase-like monooxygenase 5 340 3.0E-85 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS31805 ff1539aecf795b2f5260c7d98e4adbd0 402 SUPERFAMILY SSF51679 36 370 1.26E-92 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS10760 87b0c2a345b07090acc6e5c72fa093ac 377 Pfam PF10609 NUBPL iron-transfer P-loop NTPase 111 357 5.4E-93 T 09-03-2017 IPR019591 Mrp/NBP35 ATP-binding protein TK78_RS10760 87b0c2a345b07090acc6e5c72fa093ac 377 SUPERFAMILY SSF117916 1 88 6.54E-25 T 09-03-2017 TK78_RS10760 87b0c2a345b07090acc6e5c72fa093ac 377 Pfam PF01883 Domain of unknown function DUF59 4 76 3.2E-19 T 09-03-2017 IPR002744 Domain of unknown function DUF59 TK78_RS10760 87b0c2a345b07090acc6e5c72fa093ac 377 ProSitePatterns PS01215 Mrp family signature. 215 231 - T 09-03-2017 IPR000808 Mrp, conserved site GO:0005524 TK78_RS10760 87b0c2a345b07090acc6e5c72fa093ac 377 Gene3D G3DSA:3.40.50.300 101 356 1.6E-90 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10760 87b0c2a345b07090acc6e5c72fa093ac 377 Hamap MF_02040 Iron-sulfur cluster carrier protein. 102 358 35.135 T 09-03-2017 IPR019591 Mrp/NBP35 ATP-binding protein TK78_RS10760 87b0c2a345b07090acc6e5c72fa093ac 377 SUPERFAMILY SSF52540 111 360 2.42E-54 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06200 ee7cf65b24a54f2bdaf4c8c515cdb63e 404 Gene3D G3DSA:3.40.50.2300 165 319 6.6E-16 T 09-03-2017 TK78_RS06200 ee7cf65b24a54f2bdaf4c8c515cdb63e 404 Gene3D G3DSA:3.40.50.2300 320 374 1.1E-36 T 09-03-2017 TK78_RS06200 ee7cf65b24a54f2bdaf4c8c515cdb63e 404 Gene3D G3DSA:3.40.50.2300 41 164 1.1E-36 T 09-03-2017 TK78_RS06200 ee7cf65b24a54f2bdaf4c8c515cdb63e 404 SUPERFAMILY SSF53822 45 390 2.36E-67 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS06200 ee7cf65b24a54f2bdaf4c8c515cdb63e 404 Pfam PF13458 Periplasmic binding protein 45 388 4.1E-60 T 09-03-2017 IPR028081 Leucine-binding protein domain TK78_RS33125 82c87bc68246cd4dae8328ef62c07829 783 Pfam PF05270 Alpha-L-arabinofuranosidase B (ABFB) domain 638 777 1.6E-49 T 09-03-2017 IPR007934 Alpha-L-arabinofuranosidase B, arabinose-binding domain GO:0046373|GO:0046556 TK78_RS33125 82c87bc68246cd4dae8328ef62c07829 783 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 377 488 5.0E-6 T 09-03-2017 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 TK78_RS33125 82c87bc68246cd4dae8328ef62c07829 783 SUPERFAMILY SSF51445 332 615 1.58E-57 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS33125 82c87bc68246cd4dae8328ef62c07829 783 SUPERFAMILY SSF49785 65 238 1.07E-47 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS33125 82c87bc68246cd4dae8328ef62c07829 783 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 123 201 3.8E-17 T 09-03-2017 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 TK78_RS33125 82c87bc68246cd4dae8328ef62c07829 783 Gene3D G3DSA:2.60.120.260 65 230 3.8E-54 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS33125 82c87bc68246cd4dae8328ef62c07829 783 Pfam PF00703 Glycosyl hydrolases family 2 241 334 1.7E-10 T 09-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 TK78_RS33125 82c87bc68246cd4dae8328ef62c07829 783 Gene3D G3DSA:3.20.20.80 348 612 9.3E-46 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS33125 82c87bc68246cd4dae8328ef62c07829 783 Gene3D G3DSA:2.80.10.50 629 782 1.5E-43 T 09-03-2017 TK78_RS33125 82c87bc68246cd4dae8328ef62c07829 783 Gene3D G3DSA:2.60.40.320 231 335 4.1E-21 T 09-03-2017 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 TK78_RS33125 82c87bc68246cd4dae8328ef62c07829 783 SUPERFAMILY SSF110221 626 782 7.59E-55 T 09-03-2017 IPR007934 Alpha-L-arabinofuranosidase B, arabinose-binding domain GO:0046373|GO:0046556 TK78_RS33125 82c87bc68246cd4dae8328ef62c07829 783 SUPERFAMILY SSF49303 242 335 1.01E-13 T 09-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 TK78_RS02970 4ac37ad50e5cc26ce094a435931fd540 276 SUPERFAMILY SSF52540 26 238 6.49E-67 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS02970 4ac37ad50e5cc26ce094a435931fd540 276 ProSitePatterns PS00211 ABC transporters family signature. 155 169 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS02970 4ac37ad50e5cc26ce094a435931fd540 276 SMART SM00382 52 233 2.3E-19 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS02970 4ac37ad50e5cc26ce094a435931fd540 276 Gene3D G3DSA:3.40.50.300 24 237 5.6E-67 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS02970 4ac37ad50e5cc26ce094a435931fd540 276 Pfam PF00005 ABC transporter 43 182 1.1E-29 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS31200 2796be61028fcfee06b2d16e7939cd44 251 SUPERFAMILY SSF51735 7 245 2.31E-74 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31200 2796be61028fcfee06b2d16e7939cd44 251 Gene3D G3DSA:3.40.50.720 6 246 2.2E-72 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31200 2796be61028fcfee06b2d16e7939cd44 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 81 92 3.3E-41 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS31200 2796be61028fcfee06b2d16e7939cd44 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 155 174 3.3E-41 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS31200 2796be61028fcfee06b2d16e7939cd44 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 208 228 3.3E-41 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS31200 2796be61028fcfee06b2d16e7939cd44 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 9 26 3.3E-41 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS31200 2796be61028fcfee06b2d16e7939cd44 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 175 192 3.3E-41 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS31200 2796be61028fcfee06b2d16e7939cd44 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 129 145 3.3E-41 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS31200 2796be61028fcfee06b2d16e7939cd44 251 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 14 244 1.5E-53 T 09-03-2017 TK78_RS31200 2796be61028fcfee06b2d16e7939cd44 251 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 142 170 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS31200 2796be61028fcfee06b2d16e7939cd44 251 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 155 174 7.3E-12 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS31200 2796be61028fcfee06b2d16e7939cd44 251 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 135 143 7.3E-12 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS31200 2796be61028fcfee06b2d16e7939cd44 251 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 81 92 7.3E-12 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS17045 d2cc77dccbdf2c424dd11fdea57c1c99 319 SUPERFAMILY SSF46955 15 87 3.0E-17 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS17045 d2cc77dccbdf2c424dd11fdea57c1c99 319 Pfam PF13411 MerR HTH family regulatory protein 15 82 5.9E-18 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS17045 d2cc77dccbdf2c424dd11fdea57c1c99 319 SMART SM00422 15 83 1.0E-10 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS17045 d2cc77dccbdf2c424dd11fdea57c1c99 319 Gene3D G3DSA:1.10.1660.10 15 117 2.6E-20 T 09-03-2017 TK78_RS33010 538496af22c835259bd8d0bec8dcac1b 198 ProSitePatterns PS00704 Prokaryotic-type carbonic anhydrases signature 1. 38 45 - T 09-03-2017 IPR015892 Carbonic anhydrase, prokaryotic-like, conserved site GO:0004089|GO:0008270|GO:0015976 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 TK78_RS33010 538496af22c835259bd8d0bec8dcac1b 198 ProSitePatterns PS00705 Prokaryotic-type carbonic anhydrases signature 2. 83 103 - T 09-03-2017 IPR015892 Carbonic anhydrase, prokaryotic-like, conserved site GO:0004089|GO:0008270|GO:0015976 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 TK78_RS33010 538496af22c835259bd8d0bec8dcac1b 198 Pfam PF00484 Carbonic anhydrase 33 184 6.2E-40 T 09-03-2017 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 TK78_RS33010 538496af22c835259bd8d0bec8dcac1b 198 Gene3D G3DSA:3.40.1050.10 1 192 1.7E-57 T 09-03-2017 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 TK78_RS33010 538496af22c835259bd8d0bec8dcac1b 198 SMART SM00947 26 188 1.4E-56 T 09-03-2017 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 TK78_RS33010 538496af22c835259bd8d0bec8dcac1b 198 SUPERFAMILY SSF53056 2 189 1.83E-51 T 09-03-2017 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 TK78_RS10400 effb08e09bb24a84fd8ca61fa90a3dd2 162 Pfam PF13546 DDE superfamily endonuclease 9 125 3.4E-12 T 09-03-2017 TK78_RS18350 e6cf8f43e6535fa502a2bb8a450c0047 134 SUPERFAMILY SSF55486 20 133 2.28E-39 T 09-03-2017 TK78_RS18350 e6cf8f43e6535fa502a2bb8a450c0047 134 Pfam PF06262 Zinicin-like metallopeptidase 46 132 2.2E-33 T 09-03-2017 IPR010428 Zinicin-like metallopeptidase TK78_RS30940 9f0c096d5f1e977688c401ea3b4fea6a 443 Gene3D G3DSA:1.10.10.10 14 80 6.6E-18 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS30940 9f0c096d5f1e977688c401ea3b4fea6a 443 Gene3D G3DSA:3.90.1150.10 330 415 1.3E-5 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS30940 9f0c096d5f1e977688c401ea3b4fea6a 443 SUPERFAMILY SSF46785 12 78 2.72E-14 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS30940 9f0c096d5f1e977688c401ea3b4fea6a 443 Pfam PF00392 Bacterial regulatory proteins, gntR family 12 74 2.2E-12 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS30940 9f0c096d5f1e977688c401ea3b4fea6a 443 SUPERFAMILY SSF53383 70 433 1.58E-56 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS30940 9f0c096d5f1e977688c401ea3b4fea6a 443 SMART SM00345 15 74 1.6E-12 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS30940 9f0c096d5f1e977688c401ea3b4fea6a 443 Pfam PF00155 Aminotransferase class I and II 96 429 2.5E-15 T 09-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TK78_RS30940 9f0c096d5f1e977688c401ea3b4fea6a 443 Gene3D G3DSA:3.40.640.10 128 329 4.9E-33 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS33530 a5e6a0cc5b874f213a03d904aae3abba 300 Gene3D G3DSA:3.30.2010.10 134 190 3.1E-12 T 09-03-2017 TK78_RS33530 a5e6a0cc5b874f213a03d904aae3abba 300 Pfam PF01435 Peptidase family M48 121 202 1.0E-9 T 09-03-2017 IPR001915 Peptidase M48 GO:0004222|GO:0006508 TK78_RS08505 3016b477aaa9a8944bd06895baea73c9 343 Pfam PF01497 Periplasmic binding protein 75 310 4.7E-26 T 09-03-2017 IPR002491 ABC transporter periplasmic binding domain GO:0005488 TK78_RS08505 3016b477aaa9a8944bd06895baea73c9 343 Gene3D G3DSA:3.40.50.1980 180 337 1.4E-18 T 09-03-2017 TK78_RS08505 3016b477aaa9a8944bd06895baea73c9 343 Gene3D G3DSA:3.40.50.1980 55 179 5.3E-30 T 09-03-2017 TK78_RS08505 3016b477aaa9a8944bd06895baea73c9 343 SUPERFAMILY SSF53807 59 335 9.81E-53 T 09-03-2017 TK78_RS00905 9c9c2c475c441da5e8faedc6cdec6f30 577 TIGRFAM TIGR02891 CtaD_CoxA: cytochrome c oxidase, subunit I 34 538 5.5E-212 T 09-03-2017 IPR014241 Cytochrome c oxidase, subunit I bacterial type GO:0004129|GO:0005507|GO:0005886|GO:0006810|GO:0022900|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279 TK78_RS00905 9c9c2c475c441da5e8faedc6cdec6f30 577 SUPERFAMILY SSF81442 30 541 4.06E-172 T 09-03-2017 IPR023616 Cytochrome c oxidase, subunit I domain GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS00905 9c9c2c475c441da5e8faedc6cdec6f30 577 PRINTS PR01165 Cytochrome c oxidase subunit I signature 80 103 4.0E-100 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS00905 9c9c2c475c441da5e8faedc6cdec6f30 577 PRINTS PR01165 Cytochrome c oxidase subunit I signature 240 261 4.0E-100 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS00905 9c9c2c475c441da5e8faedc6cdec6f30 577 PRINTS PR01165 Cytochrome c oxidase subunit I signature 107 131 4.0E-100 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS00905 9c9c2c475c441da5e8faedc6cdec6f30 577 PRINTS PR01165 Cytochrome c oxidase subunit I signature 392 411 4.0E-100 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS00905 9c9c2c475c441da5e8faedc6cdec6f30 577 PRINTS PR01165 Cytochrome c oxidase subunit I signature 329 350 4.0E-100 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS00905 9c9c2c475c441da5e8faedc6cdec6f30 577 PRINTS PR01165 Cytochrome c oxidase subunit I signature 307 322 4.0E-100 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS00905 9c9c2c475c441da5e8faedc6cdec6f30 577 PRINTS PR01165 Cytochrome c oxidase subunit I signature 364 382 4.0E-100 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS00905 9c9c2c475c441da5e8faedc6cdec6f30 577 PRINTS PR01165 Cytochrome c oxidase subunit I signature 211 230 4.0E-100 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS00905 9c9c2c475c441da5e8faedc6cdec6f30 577 PRINTS PR01165 Cytochrome c oxidase subunit I signature 182 200 4.0E-100 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS00905 9c9c2c475c441da5e8faedc6cdec6f30 577 PRINTS PR01165 Cytochrome c oxidase subunit I signature 442 463 4.0E-100 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS00905 9c9c2c475c441da5e8faedc6cdec6f30 577 PRINTS PR01165 Cytochrome c oxidase subunit I signature 150 162 4.0E-100 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS00905 9c9c2c475c441da5e8faedc6cdec6f30 577 PRINTS PR01165 Cytochrome c oxidase subunit I signature 33 58 4.0E-100 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS00905 9c9c2c475c441da5e8faedc6cdec6f30 577 PRINTS PR01165 Cytochrome c oxidase subunit I signature 261 282 4.0E-100 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS00905 9c9c2c475c441da5e8faedc6cdec6f30 577 Pfam PF00115 Cytochrome C and Quinol oxidase polypeptide I 43 485 2.9E-144 T 09-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS00905 9c9c2c475c441da5e8faedc6cdec6f30 577 Gene3D G3DSA:1.20.210.10 28 554 6.4E-191 T 09-03-2017 IPR023616 Cytochrome c oxidase, subunit I domain GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS00905 9c9c2c475c441da5e8faedc6cdec6f30 577 ProSitePatterns PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 263 317 - T 09-03-2017 IPR023615 Cytochrome c oxidase, subunit I, copper-binding site GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS08875 2d26cc380eab45f10ce7244cd3c556e2 229 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2 177 5.9E-4 T 09-03-2017 TK78_RS08875 2d26cc380eab45f10ce7244cd3c556e2 229 SUPERFAMILY SSF51735 3 216 1.01E-49 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS08875 2d26cc380eab45f10ce7244cd3c556e2 229 Pfam PF00106 short chain dehydrogenase 5 189 1.7E-36 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS08875 2d26cc380eab45f10ce7244cd3c556e2 229 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 3 20 6.9E-19 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS08875 2d26cc380eab45f10ce7244cd3c556e2 229 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 165 182 6.9E-19 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS08875 2d26cc380eab45f10ce7244cd3c556e2 229 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 118 134 6.9E-19 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS08875 2d26cc380eab45f10ce7244cd3c556e2 229 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 144 163 6.9E-19 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS08875 2d26cc380eab45f10ce7244cd3c556e2 229 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 72 83 6.9E-19 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS08875 2d26cc380eab45f10ce7244cd3c556e2 229 Gene3D G3DSA:3.40.50.720 4 216 1.8E-50 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS08875 2d26cc380eab45f10ce7244cd3c556e2 229 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 131 159 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS18885 660e314ca3dccd16868cc3af6b479a5e 170 Gene3D G3DSA:1.10.10.10 5 82 3.0E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS18885 660e314ca3dccd16868cc3af6b479a5e 170 SUPERFAMILY SSF46785 6 135 1.82E-31 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS18885 660e314ca3dccd16868cc3af6b479a5e 170 Pfam PF01475 Ferric uptake regulator family 13 122 6.9E-23 T 09-03-2017 IPR002481 Ferric-uptake regulator GO:0003700|GO:0006355 TK78_RS10950 2f799dd686b6c71ab05a193158f1783e 404 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 270 337 7.2E-17 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS10950 2f799dd686b6c71ab05a193158f1783e 404 SMART SM00382 75 268 9.0E-15 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS10950 2f799dd686b6c71ab05a193158f1783e 404 Gene3D G3DSA:3.40.50.300 37 292 9.5E-83 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10950 2f799dd686b6c71ab05a193158f1783e 404 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 268 344 2.9E-23 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS10950 2f799dd686b6c71ab05a193158f1783e 404 SUPERFAMILY SSF52540 38 290 6.84E-75 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10950 2f799dd686b6c71ab05a193158f1783e 404 ProSitePatterns PS00211 ABC transporters family signature. 191 205 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS10950 2f799dd686b6c71ab05a193158f1783e 404 Pfam PF00005 ABC transporter 67 218 1.2E-33 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS11960 81fa04054531652eac5e4db9ca90e361 384 Pfam PF01590 GAF domain 124 181 1.0E-4 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS11960 81fa04054531652eac5e4db9ca90e361 384 SMART SM00267 186 364 2.2E-44 T 09-03-2017 IPR000160 GGDEF domain TK78_RS11960 81fa04054531652eac5e4db9ca90e361 384 TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain 195 350 5.9E-24 T 09-03-2017 IPR000160 GGDEF domain TK78_RS11960 81fa04054531652eac5e4db9ca90e361 384 Gene3D G3DSA:3.30.70.270 199 351 6.1E-32 T 09-03-2017 TK78_RS11960 81fa04054531652eac5e4db9ca90e361 384 SUPERFAMILY SSF55781 26 187 8.34E-11 T 09-03-2017 IPR029016 GAF domain-like TK78_RS11960 81fa04054531652eac5e4db9ca90e361 384 Gene3D G3DSA:3.30.450.40 15 191 2.7E-12 T 09-03-2017 IPR029016 GAF domain-like TK78_RS11960 81fa04054531652eac5e4db9ca90e361 384 Pfam PF00990 Diguanylate cyclase, GGDEF domain 197 349 1.4E-25 T 09-03-2017 IPR000160 GGDEF domain TK78_RS11960 81fa04054531652eac5e4db9ca90e361 384 SUPERFAMILY SSF55073 202 350 1.73E-27 T 09-03-2017 IPR029787 Nucleotide cyclase TK78_RS07360 ac601996cf1b5abf611626625643741b 659 Pfam PF06276 Ferric iron reductase FhuF-like transporter 472 632 1.0E-38 T 09-03-2017 IPR022770 Ferric iron reductase FhuF domain TK78_RS07360 ac601996cf1b5abf611626625643741b 659 Pfam PF04183 IucA / IucC family 199 450 1.6E-76 T 09-03-2017 IPR007310 Aerobactin siderophore biosynthesis, IucA/IucC, N-terminal GO:0015343|GO:0019290 TK78_RS32830 d956263c9a7ddd170aeaad8c17d50224 162 SUPERFAMILY SSF55874 20 120 9.03E-9 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS32830 d956263c9a7ddd170aeaad8c17d50224 162 Pfam PF13581 Histidine kinase-like ATPase domain 4 116 4.2E-11 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS05885 cb42bdfdc1b2dd244c86ff60418993cb 520 Gene3D G3DSA:3.40.50.1820 65 151 9.4E-54 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS05885 cb42bdfdc1b2dd244c86ff60418993cb 520 Gene3D G3DSA:3.40.50.1820 196 322 9.4E-54 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS05885 cb42bdfdc1b2dd244c86ff60418993cb 520 Gene3D G3DSA:3.40.50.1820 375 496 9.4E-54 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS05885 cb42bdfdc1b2dd244c86ff60418993cb 520 SUPERFAMILY SSF53474 70 164 1.41E-20 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS05885 cb42bdfdc1b2dd244c86ff60418993cb 520 SUPERFAMILY SSF53474 201 273 1.41E-20 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS05885 cb42bdfdc1b2dd244c86ff60418993cb 520 SUPERFAMILY SSF53474 398 496 1.41E-20 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS05885 cb42bdfdc1b2dd244c86ff60418993cb 520 Pfam PF08386 TAP-like protein 409 508 2.1E-26 T 09-03-2017 IPR013595 Peptidase S33 tripeptidyl aminopeptidase-like, C-terminal TK78_RS34105 34a3a9786d9f6beb0d19ce529e7e3605 433 Pfam PF00501 AMP-binding enzyme 83 287 6.1E-16 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS34105 34a3a9786d9f6beb0d19ce529e7e3605 433 TIGRFAM TIGR02155 PA_CoA_ligase: phenylacetate-CoA ligase 9 426 3.6E-218 T 09-03-2017 IPR011880 Phenylacetate-CoA ligase GO:0010124|GO:0047475 KEGG: 00360+6.2.1.30|MetaCyc: PWY-1341|MetaCyc: PWY-6318|MetaCyc: PWY-7716 TK78_RS34105 34a3a9786d9f6beb0d19ce529e7e3605 433 Pfam PF14535 AMP-binding enzyme C-terminal domain 333 426 8.0E-25 T 09-03-2017 IPR028154 AMP-dependent ligase, C-terminal TK78_RS34105 34a3a9786d9f6beb0d19ce529e7e3605 433 Gene3D G3DSA:3.30.300.30 323 426 4.8E-35 T 09-03-2017 TK78_RS34105 34a3a9786d9f6beb0d19ce529e7e3605 433 Gene3D G3DSA:3.40.50.980 88 246 5.8E-13 T 09-03-2017 TK78_RS34105 34a3a9786d9f6beb0d19ce529e7e3605 433 PIRSF PIRSF006444 1 428 1.3E-206 T 09-03-2017 IPR011880 Phenylacetate-CoA ligase GO:0010124|GO:0047475 KEGG: 00360+6.2.1.30|MetaCyc: PWY-1341|MetaCyc: PWY-6318|MetaCyc: PWY-7716 TK78_RS34105 34a3a9786d9f6beb0d19ce529e7e3605 433 SUPERFAMILY SSF56801 13 421 1.14E-65 T 09-03-2017 TK78_RS12750 f0ef409d923bdb4926f85e8522d72681 257 SUPERFAMILY SSF51735 3 229 1.09E-54 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS12750 f0ef409d923bdb4926f85e8522d72681 257 Pfam PF00106 short chain dehydrogenase 3 188 4.0E-41 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS12750 f0ef409d923bdb4926f85e8522d72681 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 3 20 1.1E-26 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS12750 f0ef409d923bdb4926f85e8522d72681 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 169 186 1.1E-26 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS12750 f0ef409d923bdb4926f85e8522d72681 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 125 141 1.1E-26 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS12750 f0ef409d923bdb4926f85e8522d72681 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 78 89 1.1E-26 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS12750 f0ef409d923bdb4926f85e8522d72681 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 148 167 1.1E-26 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS12750 f0ef409d923bdb4926f85e8522d72681 257 Gene3D G3DSA:3.40.50.720 3 216 4.1E-56 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS12750 f0ef409d923bdb4926f85e8522d72681 257 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 131 139 1.4E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS12750 f0ef409d923bdb4926f85e8522d72681 257 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 148 167 1.4E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS12750 f0ef409d923bdb4926f85e8522d72681 257 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 78 89 1.4E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS12750 f0ef409d923bdb4926f85e8522d72681 257 PIRSF PIRSF000126 1 252 2.1E-65 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS04245 d2480ed944410737784a63cbf23a50ad 215 TIGRFAM TIGR00164 PS_decarb_rel: phosphatidylserine decarboxylase homolog 28 213 5.2E-53 T 09-03-2017 IPR033175 Phosphatidylserine decarboxylase, archaeal-type KEGG: 00564+4.1.1.65|MetaCyc: PWY-5669 TK78_RS04245 d2480ed944410737784a63cbf23a50ad 215 Hamap MF_00664 Phosphatidylserine decarboxylase proenzyme [psd]. 14 215 32.499 T 09-03-2017 IPR033175 Phosphatidylserine decarboxylase, archaeal-type KEGG: 00564+4.1.1.65|MetaCyc: PWY-5669 TK78_RS04245 d2480ed944410737784a63cbf23a50ad 215 Pfam PF02666 Phosphatidylserine decarboxylase 56 209 5.7E-30 T 09-03-2017 IPR003817 Phosphatidylserine decarboxylase-related GO:0004609|GO:0008654 KEGG: 00564+4.1.1.65|MetaCyc: PWY-5669|Reactome: R-HSA-1483213 TK78_RS28990 1f6b49ca744be1bb948c118614b8c4f3 479 Pfam PF03600 Citrate transporter 13 195 1.3E-30 T 09-03-2017 IPR004680 Citrate transporter-like domain GO:0016021|GO:0055085 TK78_RS28990 1f6b49ca744be1bb948c118614b8c4f3 479 Pfam PF03600 Citrate transporter 243 427 4.5E-26 T 09-03-2017 IPR004680 Citrate transporter-like domain GO:0016021|GO:0055085 TK78_RS28990 1f6b49ca744be1bb948c118614b8c4f3 479 TIGRFAM TIGR00784 citMHS: citrate transporter 1 215 8.9E-84 T 09-03-2017 IPR014738 Citrate transporter GO:0015137|GO:0015746 TK78_RS03620 b1ebd0c483807e02326534f20316431a 135 Pfam PF03259 Roadblock/LC7 domain 8 100 5.5E-25 T 09-03-2017 IPR004942 Roadblock/LAMTOR2 domain TK78_RS03620 b1ebd0c483807e02326534f20316431a 135 SUPERFAMILY SSF103196 3 121 1.26E-26 T 09-03-2017 TK78_RS03620 b1ebd0c483807e02326534f20316431a 135 SMART SM00960 9 100 8.7E-20 T 09-03-2017 IPR004942 Roadblock/LAMTOR2 domain TK78_RS03620 b1ebd0c483807e02326534f20316431a 135 Gene3D G3DSA:3.30.450.30 7 127 5.2E-22 T 09-03-2017 TK78_RS17325 d3337dc8e85acdcb03268cb8cd83cc78 363 Gene3D G3DSA:3.90.1530.10 82 179 1.3E-37 T 09-03-2017 TK78_RS17325 d3337dc8e85acdcb03268cb8cd83cc78 363 TIGRFAM TIGR00180 parB_part: ParB/RepB/Spo0J family partition protein 82 258 9.0E-59 T 09-03-2017 IPR004437 ParB/RepB/Spo0J partition protein family GO:0003677 TK78_RS17325 d3337dc8e85acdcb03268cb8cd83cc78 363 SUPERFAMILY SSF110849 84 175 8.37E-28 T 09-03-2017 IPR003115 ParB/Sulfiredoxin TK78_RS17325 d3337dc8e85acdcb03268cb8cd83cc78 363 Pfam PF02195 ParB-like nuclease domain 84 172 5.6E-24 T 09-03-2017 IPR003115 ParB/Sulfiredoxin TK78_RS17325 d3337dc8e85acdcb03268cb8cd83cc78 363 SUPERFAMILY SSF109709 165 274 1.14E-32 T 09-03-2017 TK78_RS17325 d3337dc8e85acdcb03268cb8cd83cc78 363 SMART SM00470 83 173 2.6E-32 T 09-03-2017 IPR003115 ParB/Sulfiredoxin TK78_RS14420 c3d9aa611acfb7678ba2c98b84d45f0c 261 Pfam PF04672 S-adenosyl methyltransferase 7 260 2.1E-101 T 09-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type TK78_RS14420 c3d9aa611acfb7678ba2c98b84d45f0c 261 PIRSF PIRSF017393 1 261 2.2E-87 T 09-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type TK78_RS14420 c3d9aa611acfb7678ba2c98b84d45f0c 261 Gene3D G3DSA:3.40.50.150 4 260 3.3E-99 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS14420 c3d9aa611acfb7678ba2c98b84d45f0c 261 SUPERFAMILY SSF53335 15 242 4.83E-39 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS27990 2f6dd1fd5b25da3ff9f586df60e87e6a 105 SUPERFAMILY SSF50022 1 103 2.36E-32 T 09-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 TK78_RS27990 2f6dd1fd5b25da3ff9f586df60e87e6a 105 Gene3D G3DSA:2.102.10.10 1 103 7.2E-35 T 09-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 TK78_RS27990 2f6dd1fd5b25da3ff9f586df60e87e6a 105 Pfam PF00355 Rieske [2Fe-2S] domain 3 89 1.6E-21 T 09-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 TK78_RS20510 082a383ce18577734a1c08986d0b5e50 494 SUPERFAMILY SSF56601 97 493 3.59E-78 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS20510 082a383ce18577734a1c08986d0b5e50 494 Pfam PF00905 Penicillin binding protein transpeptidase domain 158 489 1.1E-64 T 09-03-2017 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 TK78_RS20510 082a383ce18577734a1c08986d0b5e50 494 Gene3D G3DSA:3.90.1310.10 75 144 1.5E-10 T 09-03-2017 TK78_RS20510 082a383ce18577734a1c08986d0b5e50 494 Gene3D G3DSA:3.40.710.10 145 492 3.9E-86 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS19660 4453554fd9658b6b2bfd03ce3a17566a 119 Gene3D G3DSA:3.30.1130.10 2 118 2.5E-46 T 09-03-2017 TK78_RS19660 4453554fd9658b6b2bfd03ce3a17566a 119 TIGRFAM TIGR00525 folB: dihydroneopterin aldolase 2 116 6.6E-36 T 09-03-2017 IPR006156 Dihydroneopterin aldolase GO:0004150|GO:0006760 KEGG: 00790+4.1.2.25|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539 TK78_RS19660 4453554fd9658b6b2bfd03ce3a17566a 119 Pfam PF02152 Dihydroneopterin aldolase 5 115 3.2E-36 T 09-03-2017 IPR006157 Dihydroneopterin aldolase/epimerase domain GO:0004150|GO:0006760 KEGG: 00790+4.1.2.25|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539 TK78_RS19660 4453554fd9658b6b2bfd03ce3a17566a 119 SMART SM00905 4 116 7.6E-50 T 09-03-2017 IPR006157 Dihydroneopterin aldolase/epimerase domain GO:0004150|GO:0006760 KEGG: 00790+4.1.2.25|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539 TK78_RS19660 4453554fd9658b6b2bfd03ce3a17566a 119 TIGRFAM TIGR00526 folB_dom: FolB domain 2 118 9.9E-33 T 09-03-2017 IPR006157 Dihydroneopterin aldolase/epimerase domain GO:0004150|GO:0006760 KEGG: 00790+4.1.2.25|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539 TK78_RS19660 4453554fd9658b6b2bfd03ce3a17566a 119 SUPERFAMILY SSF55620 2 118 6.67E-37 T 09-03-2017 TK78_RS25990 dae888bb399f962dd2d20e0da520b2a0 272 Pfam PF02591 C4-type zinc ribbon domain 230 264 6.9E-11 T 09-03-2017 IPR003743 C4-type zinc ribbon domain TK78_RS17060 984305a3830d3c31f64b93bac6ed9813 289 SUPERFAMILY SSF56784 14 278 9.67E-58 T 09-03-2017 IPR023214 HAD-like domain TK78_RS17060 984305a3830d3c31f64b93bac6ed9813 289 Gene3D G3DSA:3.40.50.1000 13 83 2.5E-48 T 09-03-2017 IPR023214 HAD-like domain TK78_RS17060 984305a3830d3c31f64b93bac6ed9813 289 Gene3D G3DSA:3.40.50.1000 182 279 2.5E-48 T 09-03-2017 IPR023214 HAD-like domain TK78_RS17060 984305a3830d3c31f64b93bac6ed9813 289 Pfam PF08282 haloacid dehalogenase-like hydrolase 16 274 7.7E-50 T 09-03-2017 IPR023214 HAD-like domain TK78_RS17060 984305a3830d3c31f64b93bac6ed9813 289 TIGRFAM TIGR00099 Cof-subfamily: Cof-like hydrolase 15 274 7.1E-43 T 09-03-2017 IPR000150 Cof protein GO:0016787 TK78_RS31090 68594091b250797bd9ef2bcf6bb30350 81 Gene3D G3DSA:1.10.1200.10 1 70 2.5E-9 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31090 68594091b250797bd9ef2bcf6bb30350 81 Pfam PF00550 Phosphopantetheine attachment site 7 62 2.2E-6 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS31090 68594091b250797bd9ef2bcf6bb30350 81 SUPERFAMILY SSF47336 1 74 5.5E-10 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS15070 6af0096597435376c54930792a5ce27a 389 SUPERFAMILY SSF56645 9 220 1.31E-33 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS15070 6af0096597435376c54930792a5ce27a 389 SUPERFAMILY SSF47203 228 366 3.49E-11 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS15070 6af0096597435376c54930792a5ce27a 389 Gene3D G3DSA:1.20.140.10 210 371 1.8E-15 T 09-03-2017 TK78_RS15070 6af0096597435376c54930792a5ce27a 389 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 233 363 1.8E-8 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS15070 6af0096597435376c54930792a5ce27a 389 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 9 110 2.3E-16 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS15070 6af0096597435376c54930792a5ce27a 389 Gene3D G3DSA:1.10.540.10 6 101 2.0E-22 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS15070 6af0096597435376c54930792a5ce27a 389 Gene3D G3DSA:2.40.110.10 149 206 3.0E-6 T 09-03-2017 TK78_RS15070 6af0096597435376c54930792a5ce27a 389 PIRSF PIRSF016578 2 383 5.9E-25 T 09-03-2017 TK78_RS13645 b123732f36fc61eb8d42db7d6464e214 289 Gene3D G3DSA:3.40.30.10 85 172 7.1E-11 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS13645 b123732f36fc61eb8d42db7d6464e214 289 SUPERFAMILY SSF52833 19 174 4.36E-49 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS13645 b123732f36fc61eb8d42db7d6464e214 289 ProSitePatterns PS01099 Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. 122 140 - T 09-03-2017 IPR002023 NADH-quinone oxidoreductase subunit E-like GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13645 b123732f36fc61eb8d42db7d6464e214 289 TIGRFAM TIGR01958 nuoE_fam: NADH-quinone oxidoreductase, E subunit 22 164 2.8E-44 T 09-03-2017 IPR002023 NADH-quinone oxidoreductase subunit E-like GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13645 b123732f36fc61eb8d42db7d6464e214 289 Pfam PF01257 Thioredoxin-like [2Fe-2S] ferredoxin 22 164 9.1E-50 T 09-03-2017 TK78_RS04305 7c07292067bc0fc0e1a9313e05968875 165 Gene3D G3DSA:3.90.79.10 20 135 6.5E-21 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS04305 7c07292067bc0fc0e1a9313e05968875 165 SUPERFAMILY SSF55811 19 135 3.79E-21 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS04305 7c07292067bc0fc0e1a9313e05968875 165 Pfam PF00293 NUDIX domain 22 130 7.7E-15 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS02625 62e98acd8f8cabcb76ea68d438625258 571 SUPERFAMILY SSF51905 497 534 7.13E-40 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS02625 62e98acd8f8cabcb76ea68d438625258 571 SUPERFAMILY SSF51905 28 360 7.13E-40 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS02625 62e98acd8f8cabcb76ea68d438625258 571 Pfam PF13450 NAD(P)-binding Rossmann-like domain 35 102 3.7E-11 T 09-03-2017 TK78_RS02625 62e98acd8f8cabcb76ea68d438625258 571 Gene3D G3DSA:3.50.50.60 244 317 2.5E-26 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS02625 62e98acd8f8cabcb76ea68d438625258 571 Gene3D G3DSA:3.50.50.60 30 135 2.5E-26 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS30790 628430a4ede5f7ad6d19a348c38f9e88 208 SMART SM00422 50 122 6.2E-15 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS30790 628430a4ede5f7ad6d19a348c38f9e88 208 Pfam PF13411 MerR HTH family regulatory protein 54 120 1.4E-12 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS30790 628430a4ede5f7ad6d19a348c38f9e88 208 SUPERFAMILY SSF46955 54 138 7.78E-14 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS30790 628430a4ede5f7ad6d19a348c38f9e88 208 Gene3D G3DSA:1.10.1660.10 56 132 2.3E-12 T 09-03-2017 TK78_RS18175 e128a329caf463c18bfe4b866d44bf50 416 Hamap MF_00138 Phosphoribosylamine--glycine ligase [purD]. 1 414 40.096 T 09-03-2017 IPR000115 Phosphoribosylglycinamide synthetase GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 TK78_RS18175 e128a329caf463c18bfe4b866d44bf50 416 SUPERFAMILY SSF52440 2 101 2.3E-30 T 09-03-2017 IPR016185 Pre-ATP-grasp domain TK78_RS18175 e128a329caf463c18bfe4b866d44bf50 416 SUPERFAMILY SSF51246 316 413 3.71E-25 T 09-03-2017 IPR011054 Rudiment single hybrid motif Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TK78_RS18175 e128a329caf463c18bfe4b866d44bf50 416 Gene3D G3DSA:3.30.1490.20 122 178 5.8E-16 T 09-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 TK78_RS18175 e128a329caf463c18bfe4b866d44bf50 416 TIGRFAM TIGR00877 purD: phosphoribosylamine--glycine ligase 2 414 3.2E-143 T 09-03-2017 IPR000115 Phosphoribosylglycinamide synthetase GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 TK78_RS18175 e128a329caf463c18bfe4b866d44bf50 416 Gene3D G3DSA:3.40.50.20 2 93 3.9E-33 T 09-03-2017 IPR016185 Pre-ATP-grasp domain TK78_RS18175 e128a329caf463c18bfe4b866d44bf50 416 Gene3D G3DSA:3.30.470.20 179 316 2.8E-55 T 09-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 TK78_RS18175 e128a329caf463c18bfe4b866d44bf50 416 SMART SM01209 101 283 2.2E-111 T 09-03-2017 TK78_RS18175 e128a329caf463c18bfe4b866d44bf50 416 Pfam PF02843 Phosphoribosylglycinamide synthetase, C domain 319 411 3.5E-26 T 09-03-2017 IPR020560 Phosphoribosylglycinamide synthetase, C-domain GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 TK78_RS18175 e128a329caf463c18bfe4b866d44bf50 416 ProSitePatterns PS00184 Phosphoribosylglycinamide synthetase signature. 277 284 - T 09-03-2017 IPR020559 Phosphoribosylglycinamide synthetase, conserved site GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 TK78_RS18175 e128a329caf463c18bfe4b866d44bf50 416 Pfam PF02844 Phosphoribosylglycinamide synthetase, N domain 2 100 1.1E-29 T 09-03-2017 IPR020562 Phosphoribosylglycinamide synthetase, N-terminal GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 TK78_RS18175 e128a329caf463c18bfe4b866d44bf50 416 SUPERFAMILY SSF56059 102 306 1.17E-52 T 09-03-2017 TK78_RS18175 e128a329caf463c18bfe4b866d44bf50 416 Gene3D G3DSA:3.90.600.10 318 413 4.9E-31 T 09-03-2017 IPR020560 Phosphoribosylglycinamide synthetase, C-domain GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 TK78_RS18175 e128a329caf463c18bfe4b866d44bf50 416 Pfam PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain 101 283 8.3E-64 T 09-03-2017 IPR020561 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 TK78_RS18175 e128a329caf463c18bfe4b866d44bf50 416 SMART SM01210 318 414 1.3E-44 T 09-03-2017 IPR020560 Phosphoribosylglycinamide synthetase, C-domain GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 TK78_RS23540 087ab566b57380d29b83f21141448e69 137 Gene3D G3DSA:3.10.180.10 6 137 2.8E-32 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS23540 087ab566b57380d29b83f21141448e69 137 SUPERFAMILY SSF54593 5 135 4.03E-27 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS23540 087ab566b57380d29b83f21141448e69 137 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 5 131 8.1E-15 T 09-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain TK78_RS28495 cc02b56b554cafa4ec9fa76ccf044c80 263 ProDom PD040491 SCO1799 RV1486C/MT1533 MB1522C CGL1536 ML1804 MAV321 22 233 9.0E-69 T 09-03-2017 TK78_RS33300 c186ab1a952250aab29f09fb2e43712f 310 ProSitePatterns PS00583 pfkB family of carbohydrate kinases signature 1. 30 54 - T 09-03-2017 IPR002173 Carbohydrate/puine kinase, PfkB, conserved site GO:0016773 TK78_RS33300 c186ab1a952250aab29f09fb2e43712f 310 SUPERFAMILY SSF53613 6 305 1.43E-60 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS33300 c186ab1a952250aab29f09fb2e43712f 310 Gene3D G3DSA:3.40.1190.20 6 307 3.2E-62 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS33300 c186ab1a952250aab29f09fb2e43712f 310 Pfam PF00294 pfkB family carbohydrate kinase 6 298 3.9E-40 T 09-03-2017 IPR011611 Carbohydrate kinase PfkB TK78_RS09380 9ca02005cad5e71b70bc595e0060cb31 224 SUPERFAMILY SSF52172 1 136 1.01E-30 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS09380 9ca02005cad5e71b70bc595e0060cb31 224 Gene3D G3DSA:1.10.10.10 164 205 8.0E-5 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS09380 9ca02005cad5e71b70bc595e0060cb31 224 PIRSF PIRSF006171 1 222 6.4E-69 T 09-03-2017 IPR024187 Signal transduction response regulator, citrate/malate metabolism GO:0001071|GO:0003677|GO:0005737|GO:0009605 TK78_RS09380 9ca02005cad5e71b70bc595e0060cb31 224 Gene3D G3DSA:3.40.50.2300 1 120 2.2E-26 T 09-03-2017 TK78_RS09380 9ca02005cad5e71b70bc595e0060cb31 224 SMART SM00448 2 115 2.3E-21 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS09380 9ca02005cad5e71b70bc595e0060cb31 224 Pfam PF00072 Response regulator receiver domain 4 115 3.1E-20 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS11190 4ed116d0f7d63017341922637adc7b95 182 Gene3D G3DSA:3.90.1140.10 8 151 9.2E-13 T 09-03-2017 IPR009097 RNA ligase/cyclic nucleotide phosphodiesterase TK78_RS11190 4ed116d0f7d63017341922637adc7b95 182 Pfam PF13563 2'-5' RNA ligase superfamily 33 133 9.3E-10 T 09-03-2017 TK78_RS11190 4ed116d0f7d63017341922637adc7b95 182 SUPERFAMILY SSF55144 7 140 9.59E-14 T 09-03-2017 IPR009097 RNA ligase/cyclic nucleotide phosphodiesterase TK78_RS30390 b667fe664d82f8b76fe1d35fd622bb86 358 Gene3D G3DSA:1.10.600.10 4 313 4.8E-101 T 09-03-2017 IPR008949 Isoprenoid synthase domain TK78_RS30390 b667fe664d82f8b76fe1d35fd622bb86 358 Pfam PF03936 Terpene synthase family, metal binding domain 27 267 3.4E-6 T 09-03-2017 IPR005630 Terpene synthase, metal-binding domain GO:0000287|GO:0010333|GO:0016829 TK78_RS30390 b667fe664d82f8b76fe1d35fd622bb86 358 SUPERFAMILY SSF48576 5 313 3.17E-64 T 09-03-2017 IPR008949 Isoprenoid synthase domain TK78_RS32000 4427fb1563232e74e9a25ec1c4d92d11 324 Gene3D G3DSA:3.40.50.1820 10 322 2.5E-86 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS32000 4427fb1563232e74e9a25ec1c4d92d11 324 SUPERFAMILY SSF53474 27 321 1.25E-65 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS32000 4427fb1563232e74e9a25ec1c4d92d11 324 Pfam PF07859 alpha/beta hydrolase fold 87 295 5.2E-63 T 09-03-2017 IPR013094 Alpha/beta hydrolase fold-3 GO:0008152|GO:0016787 TK78_RS13955 af4b53a40c7ee530db20b676629e6719 217 Gene3D G3DSA:1.10.357.10 6 212 1.6E-43 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS13955 af4b53a40c7ee530db20b676629e6719 217 Pfam PF00440 Bacterial regulatory proteins, tetR family 25 66 3.3E-11 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS13955 af4b53a40c7ee530db20b676629e6719 217 SUPERFAMILY SSF46689 9 82 5.49E-18 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS13955 af4b53a40c7ee530db20b676629e6719 217 SUPERFAMILY SSF48498 92 213 9.56E-30 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS10775 7de6f0fcdb488003cffebcd217d723cb 706 SMART SM00228 611 691 0.001 T 09-03-2017 IPR001478 PDZ domain GO:0005515 TK78_RS10775 7de6f0fcdb488003cffebcd217d723cb 706 SUPERFAMILY SSF50494 387 616 3.75E-54 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS10775 7de6f0fcdb488003cffebcd217d723cb 706 Pfam PF13365 Trypsin-like peptidase domain 416 562 1.0E-33 T 09-03-2017 TK78_RS10775 7de6f0fcdb488003cffebcd217d723cb 706 SUPERFAMILY SSF50156 592 700 2.5E-16 T 09-03-2017 IPR001478 PDZ domain GO:0005515 TK78_RS10775 7de6f0fcdb488003cffebcd217d723cb 706 Pfam PF13180 PDZ domain 611 700 4.8E-19 T 09-03-2017 IPR001478 PDZ domain GO:0005515 TK78_RS10775 7de6f0fcdb488003cffebcd217d723cb 706 Gene3D G3DSA:2.40.10.10 411 489 2.6E-26 T 09-03-2017 TK78_RS10775 7de6f0fcdb488003cffebcd217d723cb 706 Gene3D G3DSA:2.40.10.10 490 613 1.0E-42 T 09-03-2017 TK78_RS10775 7de6f0fcdb488003cffebcd217d723cb 706 PRINTS PR00834 HtrA/DegQ protease family signature 533 550 3.1E-42 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS10775 7de6f0fcdb488003cffebcd217d723cb 706 PRINTS PR00834 HtrA/DegQ protease family signature 425 437 3.1E-42 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS10775 7de6f0fcdb488003cffebcd217d723cb 706 PRINTS PR00834 HtrA/DegQ protease family signature 649 661 3.1E-42 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS10775 7de6f0fcdb488003cffebcd217d723cb 706 PRINTS PR00834 HtrA/DegQ protease family signature 490 514 3.1E-42 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS10775 7de6f0fcdb488003cffebcd217d723cb 706 PRINTS PR00834 HtrA/DegQ protease family signature 555 572 3.1E-42 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS10775 7de6f0fcdb488003cffebcd217d723cb 706 PRINTS PR00834 HtrA/DegQ protease family signature 449 469 3.1E-42 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS10775 7de6f0fcdb488003cffebcd217d723cb 706 Gene3D G3DSA:2.30.42.10 614 704 3.7E-19 T 09-03-2017 IPR001478 PDZ domain GO:0005515 TK78_RS06925 5f845b23f95fc15f1f5d77fddbf8cc97 217 Pfam PF00072 Response regulator receiver domain 3 113 1.1E-25 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS06925 5f845b23f95fc15f1f5d77fddbf8cc97 217 SUPERFAMILY SSF52172 2 172 8.94E-35 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS06925 5f845b23f95fc15f1f5d77fddbf8cc97 217 Gene3D G3DSA:1.10.10.10 125 217 3.7E-27 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS06925 5f845b23f95fc15f1f5d77fddbf8cc97 217 Gene3D G3DSA:3.40.50.2300 2 119 7.5E-33 T 09-03-2017 TK78_RS06925 5f845b23f95fc15f1f5d77fddbf8cc97 217 SMART SM00862 145 217 1.3E-21 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS06925 5f845b23f95fc15f1f5d77fddbf8cc97 217 SMART SM00448 1 112 2.9E-33 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS06925 5f845b23f95fc15f1f5d77fddbf8cc97 217 Pfam PF00486 Transcriptional regulatory protein, C terminal 147 217 2.3E-22 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS16040 5752de6e86ae84865a4ab79380815143 181 Pfam PF10722 Putative bacterial sensory transduction regulator 30 160 6.7E-14 T 09-03-2017 IPR019660 Putative sensory transduction regulator YbjN TK78_RS21065 a345c605db8c48bfc692b1b09dbc431b 265 SUPERFAMILY SSF51735 11 252 1.23E-78 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS21065 a345c605db8c48bfc692b1b09dbc431b 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 87 98 7.7E-41 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS21065 a345c605db8c48bfc692b1b09dbc431b 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 13 30 7.7E-41 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS21065 a345c605db8c48bfc692b1b09dbc431b 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 136 152 7.7E-41 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS21065 a345c605db8c48bfc692b1b09dbc431b 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 182 199 7.7E-41 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS21065 a345c605db8c48bfc692b1b09dbc431b 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 161 180 7.7E-41 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS21065 a345c605db8c48bfc692b1b09dbc431b 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 214 234 7.7E-41 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS21065 a345c605db8c48bfc692b1b09dbc431b 265 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 161 180 4.5E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS21065 a345c605db8c48bfc692b1b09dbc431b 265 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 87 98 4.5E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS21065 a345c605db8c48bfc692b1b09dbc431b 265 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 142 150 4.5E-10 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS21065 a345c605db8c48bfc692b1b09dbc431b 265 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 18 250 5.2E-66 T 09-03-2017 TK78_RS21065 a345c605db8c48bfc692b1b09dbc431b 265 Gene3D G3DSA:3.40.50.720 8 253 1.4E-81 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS24715 97bfe4ff40cf7a0aa27c372f9f5541ce 439 Pfam PF07690 Major Facilitator Superfamily 25 385 1.0E-35 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS24715 97bfe4ff40cf7a0aa27c372f9f5541ce 439 SUPERFAMILY SSF103473 9 425 2.88E-69 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS24715 97bfe4ff40cf7a0aa27c372f9f5541ce 439 Gene3D G3DSA:1.20.1250.20 239 425 2.5E-16 T 09-03-2017 TK78_RS24715 97bfe4ff40cf7a0aa27c372f9f5541ce 439 Gene3D G3DSA:1.20.1250.20 18 214 2.2E-41 T 09-03-2017 TK78_RS15930 d8be24e60316908458797aa24e684fff 90 SUPERFAMILY SSF143212 2 84 1.1E-28 T 09-03-2017 TK78_RS15930 d8be24e60316908458797aa24e684fff 90 Pfam PF08962 Domain of unknown function (DUF1876) 7 85 7.9E-29 T 09-03-2017 IPR015057 Protein of unknown function DUF1876 TK78_RS15930 d8be24e60316908458797aa24e684fff 90 ProDom PD280340 RV1738/MT1780 MB2665C MB1767 SCO3163 RV2632C/MT2708 6 81 3.0E-29 T 09-03-2017 IPR015057 Protein of unknown function DUF1876 TK78_RS20820 a4cfe34b1217127cc839b5eabc0b5f21 363 SUPERFAMILY SSF56266 10 347 2.09E-70 T 09-03-2017 IPR016117 ArgJ-like domain KEGG: 00220+2.3.1.35+2.3.1.1|MetaCyc: PWY-5154 TK78_RS20820 a4cfe34b1217127cc839b5eabc0b5f21 363 Pfam PF03576 Peptidase family S58 15 349 9.3E-71 T 09-03-2017 IPR005321 Peptidase S58, DmpA TK78_RS20820 a4cfe34b1217127cc839b5eabc0b5f21 363 Gene3D G3DSA:3.60.70.12 14 353 1.4E-88 T 09-03-2017 IPR016117 ArgJ-like domain KEGG: 00220+2.3.1.35+2.3.1.1|MetaCyc: PWY-5154 TK78_RS07870 5b6d2ffaa4043781b03c865a1ec915d0 385 SUPERFAMILY SSF56014 275 359 8.5E-11 T 09-03-2017 TK78_RS07870 5b6d2ffaa4043781b03c865a1ec915d0 385 PIRSF PIRSF004640 11 373 8.6E-144 T 09-03-2017 IPR016425 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial GO:0005506|GO:0008299|GO:0046429|GO:0055114 KEGG: 00900+1.17.7.3 TK78_RS07870 5b6d2ffaa4043781b03c865a1ec915d0 385 Hamap MF_00159 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin) [ispG]. 16 367 33.419 T 09-03-2017 IPR004588 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type GO:0016114|GO:0046429|GO:0055114 KEGG: 00900+1.17.7.3 TK78_RS07870 5b6d2ffaa4043781b03c865a1ec915d0 385 Pfam PF04551 GcpE protein 22 361 2.8E-133 T 09-03-2017 IPR004588 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type GO:0016114|GO:0046429|GO:0055114 KEGG: 00900+1.17.7.3 TK78_RS07870 5b6d2ffaa4043781b03c865a1ec915d0 385 SUPERFAMILY SSF51717 45 219 5.96E-9 T 09-03-2017 IPR011005 Dihydropteroate synthase-like GO:0044237 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TK78_RS07870 5b6d2ffaa4043781b03c865a1ec915d0 385 TIGRFAM TIGR00612 ispG_gcpE: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 18 360 3.7E-126 T 09-03-2017 IPR004588 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type GO:0016114|GO:0046429|GO:0055114 KEGG: 00900+1.17.7.3 TK78_RS13075 a32e555900454a6cf94d58a3b8c3f63b 200 SUPERFAMILY SSF54211 101 180 6.83E-25 T 09-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold TK78_RS13075 a32e555900454a6cf94d58a3b8c3f63b 200 Hamap MF_01307_B 30S ribosomal protein S5 [rpsE]. 1 185 34.743 T 09-03-2017 IPR005712 Ribosomal protein S5, bacterial-type GO:0003735|GO:0006412|GO:0015935 TK78_RS13075 a32e555900454a6cf94d58a3b8c3f63b 200 Gene3D G3DSA:3.30.160.20 33 94 8.0E-29 T 09-03-2017 IPR014720 Double-stranded RNA-binding domain TK78_RS13075 a32e555900454a6cf94d58a3b8c3f63b 200 Pfam PF03719 Ribosomal protein S5, C-terminal domain 109 179 8.0E-29 T 09-03-2017 IPR005324 Ribosomal protein S5, C-terminal GO:0003735|GO:0005840|GO:0006412 TK78_RS13075 a32e555900454a6cf94d58a3b8c3f63b 200 SUPERFAMILY SSF54768 32 98 4.39E-22 T 09-03-2017 TK78_RS13075 a32e555900454a6cf94d58a3b8c3f63b 200 Gene3D G3DSA:3.30.230.10 100 180 2.4E-32 T 09-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TK78_RS13075 a32e555900454a6cf94d58a3b8c3f63b 200 ProSitePatterns PS00585 Ribosomal protein S5 signature. 50 82 - T 09-03-2017 IPR018192 Ribosomal protein S5, N-terminal, conserved site TK78_RS13075 a32e555900454a6cf94d58a3b8c3f63b 200 Pfam PF00333 Ribosomal protein S5, N-terminal domain 35 97 1.3E-27 T 09-03-2017 IPR013810 Ribosomal protein S5, N-terminal GO:0003723|GO:0003735|GO:0005840|GO:0006412 TK78_RS13075 a32e555900454a6cf94d58a3b8c3f63b 200 TIGRFAM TIGR01021 rpsE_bact: ribosomal protein uS5 31 185 2.5E-68 T 09-03-2017 IPR005712 Ribosomal protein S5, bacterial-type GO:0003735|GO:0006412|GO:0015935 TK78_RS32770 b8a45fc2900a8192fe1edad65bcd9b51 454 Pfam PF01546 Peptidase family M20/M25/M40 86 439 2.4E-37 T 09-03-2017 IPR002933 Peptidase M20 GO:0008152|GO:0016787 TK78_RS32770 b8a45fc2900a8192fe1edad65bcd9b51 454 Gene3D G3DSA:3.30.70.360 199 356 6.9E-37 T 09-03-2017 IPR011650 Peptidase M20, dimerisation domain TK78_RS32770 b8a45fc2900a8192fe1edad65bcd9b51 454 SUPERFAMILY SSF53187 361 450 1.34E-55 T 09-03-2017 TK78_RS32770 b8a45fc2900a8192fe1edad65bcd9b51 454 SUPERFAMILY SSF53187 6 199 1.34E-55 T 09-03-2017 TK78_RS32770 b8a45fc2900a8192fe1edad65bcd9b51 454 Gene3D G3DSA:3.40.630.10 7 193 8.5E-62 T 09-03-2017 TK78_RS32770 b8a45fc2900a8192fe1edad65bcd9b51 454 Gene3D G3DSA:3.40.630.10 360 451 8.5E-62 T 09-03-2017 TK78_RS32770 b8a45fc2900a8192fe1edad65bcd9b51 454 Pfam PF07687 Peptidase dimerisation domain 205 347 6.4E-15 T 09-03-2017 IPR011650 Peptidase M20, dimerisation domain TK78_RS17970 d9e2e0949e91fcc462324c9e95eb4b89 214 SUPERFAMILY SSF53597 58 213 1.54E-24 T 09-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 TK78_RS17970 d9e2e0949e91fcc462324c9e95eb4b89 214 Pfam PF01872 RibD C-terminal domain 9 189 5.4E-12 T 09-03-2017 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 TK78_RS17970 d9e2e0949e91fcc462324c9e95eb4b89 214 Gene3D G3DSA:3.40.430.10 9 213 4.5E-39 T 09-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 TK78_RS23255 238a978053fb048d4b8f18bbff2a7eaa 677 Pfam PF13454 FAD-NAD(P)-binding 9 194 1.9E-44 T 09-03-2017 TK78_RS23255 238a978053fb048d4b8f18bbff2a7eaa 677 SUPERFAMILY SSF51905 601 657 3.37E-8 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS23255 238a978053fb048d4b8f18bbff2a7eaa 677 SUPERFAMILY SSF51905 7 216 3.37E-8 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS23255 238a978053fb048d4b8f18bbff2a7eaa 677 Gene3D G3DSA:3.50.50.60 7 201 3.7E-14 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS23255 238a978053fb048d4b8f18bbff2a7eaa 677 Gene3D G3DSA:3.50.50.60 592 631 3.7E-14 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS25915 28a8c674562bcd8011796a20be019c93 259 Pfam PF07398 MDMPI C-terminal domain 150 250 4.0E-12 T 09-03-2017 IPR010872 MDMPI C-terminal TK78_RS25915 28a8c674562bcd8011796a20be019c93 259 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 12 138 1.9E-21 T 09-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 TK78_RS25915 28a8c674562bcd8011796a20be019c93 259 TIGRFAM TIGR03083 TIGR03083: uncharacterized Actinobacterial protein TIGR03083 14 231 4.4E-25 T 09-03-2017 IPR017517 Conserved hypothetical protein CHP03083, actinobacterial-type TK78_RS25915 28a8c674562bcd8011796a20be019c93 259 SUPERFAMILY SSF109854 6 141 2.98E-7 T 09-03-2017 TK78_RS13560 0fad2f89447a5f8fe3cf83044b0c6095 664 Gene3D G3DSA:2.60.120.260 331 518 8.4E-48 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS13560 0fad2f89447a5f8fe3cf83044b0c6095 664 Pfam PF08530 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain 304 511 4.1E-40 T 09-03-2017 IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal GO:0008239 TK78_RS13560 0fad2f89447a5f8fe3cf83044b0c6095 664 TIGRFAM TIGR00976 /NonD: hydrolase CocE/NonD family protein 22 495 6.2E-66 T 09-03-2017 IPR005674 CocE/Serine esterase GO:0016787 TK78_RS13560 0fad2f89447a5f8fe3cf83044b0c6095 664 SUPERFAMILY SSF49785 291 518 4.46E-46 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS13560 0fad2f89447a5f8fe3cf83044b0c6095 664 Gene3D G3DSA:3.40.50.1820 11 156 1.0E-73 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS13560 0fad2f89447a5f8fe3cf83044b0c6095 664 Gene3D G3DSA:3.40.50.1820 216 330 1.0E-73 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS13560 0fad2f89447a5f8fe3cf83044b0c6095 664 SUPERFAMILY SSF53474 11 338 4.63E-67 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS13560 0fad2f89447a5f8fe3cf83044b0c6095 664 SMART SM00939 291 537 2.0E-68 T 09-03-2017 IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal GO:0008239 TK78_RS13560 0fad2f89447a5f8fe3cf83044b0c6095 664 Pfam PF02129 X-Pro dipeptidyl-peptidase (S15 family) 22 273 1.9E-64 T 09-03-2017 IPR000383 Xaa-Pro dipeptidyl-peptidase-like domain GO:0016787 TK78_RS23035 bb07f034009b226894aeb015f22b66a8 430 Gene3D G3DSA:1.10.101.10 360 428 7.3E-9 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS23035 bb07f034009b226894aeb015f22b66a8 430 Gene3D G3DSA:1.10.101.10 262 332 3.0E-6 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS23035 bb07f034009b226894aeb015f22b66a8 430 SUPERFAMILY SSF54001 110 203 3.07E-10 T 09-03-2017 TK78_RS23035 bb07f034009b226894aeb015f22b66a8 430 SUPERFAMILY SSF47090 262 332 1.8E-6 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS23035 bb07f034009b226894aeb015f22b66a8 430 Gene3D G3DSA:3.90.1720.10 114 234 1.1E-13 T 09-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain TK78_RS23035 bb07f034009b226894aeb015f22b66a8 430 SUPERFAMILY SSF47090 356 429 1.26E-7 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS20260 25b122a520f0483fecbd89e7cc771d9f 485 TIGRFAM TIGR00148 TIGR00148: decarboxylase, UbiD family 6 450 6.9E-138 T 09-03-2017 IPR002830 UbiD decarboxylyase family GO:0016831 KEGG: 00130+4.1.1.98|MetaCyc: PWY-5855|MetaCyc: PWY-5856|MetaCyc: PWY-5857|MetaCyc: PWY-6708|MetaCyc: PWY-6978 TK78_RS20260 25b122a520f0483fecbd89e7cc771d9f 485 Gene3D G3DSA:1.20.5.570 450 485 1.4E-6 T 09-03-2017 TK78_RS20260 25b122a520f0483fecbd89e7cc771d9f 485 SUPERFAMILY SSF143968 320 485 2.88E-54 T 09-03-2017 TK78_RS20260 25b122a520f0483fecbd89e7cc771d9f 485 Gene3D G3DSA:3.40.1670.10 334 449 8.3E-38 T 09-03-2017 TK78_RS20260 25b122a520f0483fecbd89e7cc771d9f 485 TIGRFAM TIGR03701 mena_SCO4490: menaquinone biosynthesis decarboxylase, SCO4490 family 9 442 2.2E-194 T 09-03-2017 IPR022390 4-hydroxybenzoate decarboxylase subunit C GO:0016831 TK78_RS20260 25b122a520f0483fecbd89e7cc771d9f 485 Pfam PF01977 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 10 425 3.9E-158 T 09-03-2017 IPR002830 UbiD decarboxylyase family GO:0016831 KEGG: 00130+4.1.1.98|MetaCyc: PWY-5855|MetaCyc: PWY-5856|MetaCyc: PWY-5857|MetaCyc: PWY-6708|MetaCyc: PWY-6978 TK78_RS20260 25b122a520f0483fecbd89e7cc771d9f 485 SUPERFAMILY SSF50475 3 319 4.32E-113 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS29605 798783ae34a1e6e099282944af13864b 379 Hamap MF_00281 Phenylalanine--tRNA ligase alpha subunit [pheS]. 25 375 45.553 T 09-03-2017 IPR022911 Phenylalanine-tRNA ligase alpha chain 1, bacterial GO:0004826 KEGG: 00970+6.1.1.20 TK78_RS29605 798783ae34a1e6e099282944af13864b 379 Gene3D G3DSA:3.30.930.10 26 376 9.7E-120 T 09-03-2017 TK78_RS29605 798783ae34a1e6e099282944af13864b 379 Pfam PF01409 tRNA synthetases class II core domain (F) 109 374 3.2E-102 T 09-03-2017 IPR002319 Phenylalanyl-tRNA synthetase GO:0000049|GO:0004812|GO:0005524|GO:0005737|GO:0043039 KEGG: 00970+6.1.1.20 TK78_RS29605 798783ae34a1e6e099282944af13864b 379 SUPERFAMILY SSF55681 109 376 1.26E-75 T 09-03-2017 TK78_RS29605 798783ae34a1e6e099282944af13864b 379 TIGRFAM TIGR00468 pheS: phenylalanine--tRNA ligase, alpha subunit 67 373 2.8E-89 T 09-03-2017 IPR004529 Phenylalanyl-tRNA synthetase, class IIc, alpha subunit GO:0000166|GO:0004826|GO:0005524|GO:0005737|GO:0006432 KEGG: 00970+6.1.1.20|Reactome: R-HSA-379716 TK78_RS29605 798783ae34a1e6e099282944af13864b 379 Pfam PF02912 Aminoacyl tRNA synthetase class II, N-terminal domain 37 104 2.9E-15 T 09-03-2017 IPR004188 Phenylalanine-tRNA ligase, class II, N-terminal GO:0000166|GO:0004826|GO:0005524|GO:0005737|GO:0006432 KEGG: 00970+6.1.1.20 TK78_RS29605 798783ae34a1e6e099282944af13864b 379 SUPERFAMILY SSF46589 30 115 1.88E-13 T 09-03-2017 IPR010978 tRNA-binding arm GO:0000166 TK78_RS19620 9267a63a82c3e5ad3a3e229ce5d7bc0b 377 TIGRFAM TIGR03883 DUF2342_F420: uncharacterized protein, coenzyme F420 biosynthesis associated 10 372 1.6E-140 T 09-03-2017 IPR022454 Conserved hypothetical protein CHP03883, F420 biosynthesis associated TK78_RS19620 9267a63a82c3e5ad3a3e229ce5d7bc0b 377 SUPERFAMILY SSF55486 9 371 1.03E-105 T 09-03-2017 TK78_RS19620 9267a63a82c3e5ad3a3e229ce5d7bc0b 377 Pfam PF10103 Zinicin-like metallopeptidase 10 368 9.8E-121 T 09-03-2017 IPR018766 Zinicin-like metallopeptidase type 2 TK78_RS19620 9267a63a82c3e5ad3a3e229ce5d7bc0b 377 TIGRFAM TIGR03624 TIGR03624: putative hydrolase 10 372 2.5E-124 T 09-03-2017 IPR018766 Zinicin-like metallopeptidase type 2 TK78_RS20285 c7634210412a13ddc0e6bd637a501e8d 387 PIRSF PIRSF004762 3 380 1.9E-99 T 09-03-2017 IPR005244 FO synthase, subunit 2-like GO:0016765|GO:0051188|GO:0051539 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198 TK78_RS20285 c7634210412a13ddc0e6bd637a501e8d 387 TIGRFAM TIGR00423 TIGR00423: radical SAM domain protein, CofH subfamily 52 368 2.4E-91 T 09-03-2017 IPR020050 FO synthase, subunit 2 GO:0016765 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198 TK78_RS20285 c7634210412a13ddc0e6bd637a501e8d 387 Hamap MF_00993 Aminodeoxyfutalosine synthase [mqnE]. 7 371 48.151 T 09-03-2017 IPR022432 Aminodeoxyfutalosine synthase GO:0009234 KEGG: 00130+2.5.1.120|MetaCyc: PWY-7371|MetaCyc: PWY-7374 TK78_RS20285 c7634210412a13ddc0e6bd637a501e8d 387 Gene3D G3DSA:3.20.20.70 17 360 3.0E-54 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS20285 c7634210412a13ddc0e6bd637a501e8d 387 TIGRFAM TIGR03700 mena_SCO4494: putative menaquinone biosynthesis radical SAM enzyme, SCO4494 family 10 367 3.6E-163 T 09-03-2017 IPR022432 Aminodeoxyfutalosine synthase GO:0009234 KEGG: 00130+2.5.1.120|MetaCyc: PWY-7371|MetaCyc: PWY-7374 TK78_RS20285 c7634210412a13ddc0e6bd637a501e8d 387 Pfam PF04055 Radical SAM superfamily 61 229 5.5E-12 T 09-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 TK78_RS20285 c7634210412a13ddc0e6bd637a501e8d 387 SUPERFAMILY SSF102114 16 361 7.32E-43 T 09-03-2017 TK78_RS25165 ad07e3712e042ad35f310b200db516d4 134 Gene3D G3DSA:3.10.180.10 1 129 1.8E-25 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS25165 ad07e3712e042ad35f310b200db516d4 134 SUPERFAMILY SSF54593 4 130 1.73E-20 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS18640 0011b91a072e209b4f2d3105cf2c7a73 258 TIGRFAM TIGR00972 3a0107s01c2: phosphate ABC transporter, ATP-binding protein 5 258 1.5E-113 T 09-03-2017 IPR005670 Phosphate transport system permease protein 1 GO:0005315|GO:0016020|GO:0035435 TK78_RS18640 0011b91a072e209b4f2d3105cf2c7a73 258 SMART SM00382 29 229 6.7E-11 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS18640 0011b91a072e209b4f2d3105cf2c7a73 258 SUPERFAMILY SSF52540 5 246 4.24E-57 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18640 0011b91a072e209b4f2d3105cf2c7a73 258 ProSitePatterns PS00211 ABC transporters family signature. 149 163 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS18640 0011b91a072e209b4f2d3105cf2c7a73 258 Gene3D G3DSA:3.40.50.300 4 251 1.7E-65 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18640 0011b91a072e209b4f2d3105cf2c7a73 258 Pfam PF00005 ABC transporter 21 176 3.0E-30 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS04220 ee13b4406bf07cace00c3c67b69e70a7 445 TIGRFAM TIGR01751 crot-CoA-red: crotonyl-CoA carboxylase/reductase 31 428 3.9E-193 T 09-03-2017 IPR010085 Crotonyl-CoA reductase GO:0043880 KEGG: 00650+1.3.1.86 TK78_RS04220 ee13b4406bf07cace00c3c67b69e70a7 445 Pfam PF00107 Zinc-binding dehydrogenase 236 380 1.9E-38 T 09-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 TK78_RS04220 ee13b4406bf07cace00c3c67b69e70a7 445 Gene3D G3DSA:3.40.50.720 232 364 1.7E-23 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS04220 ee13b4406bf07cace00c3c67b69e70a7 445 Gene3D G3DSA:3.90.180.10 46 231 5.5E-30 T 09-03-2017 IPR011032 GroES-like TK78_RS04220 ee13b4406bf07cace00c3c67b69e70a7 445 SMART SM00829 49 415 1.8E-10 T 09-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 TK78_RS04220 ee13b4406bf07cace00c3c67b69e70a7 445 SUPERFAMILY SSF51735 198 392 2.32E-37 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS04220 ee13b4406bf07cace00c3c67b69e70a7 445 SUPERFAMILY SSF50129 51 230 6.52E-28 T 09-03-2017 IPR011032 GroES-like TK78_RS04220 ee13b4406bf07cace00c3c67b69e70a7 445 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 113 189 7.0E-6 T 09-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 TK78_RS19045 fb36d3981393bc4abe860e21026d0a48 442 Gene3D G3DSA:1.20.1250.20 219 401 1.5E-21 T 09-03-2017 TK78_RS19045 fb36d3981393bc4abe860e21026d0a48 442 Pfam PF07690 Major Facilitator Superfamily 25 249 4.0E-33 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS19045 fb36d3981393bc4abe860e21026d0a48 442 SUPERFAMILY SSF103473 18 403 1.7E-62 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS19045 fb36d3981393bc4abe860e21026d0a48 442 Gene3D G3DSA:1.20.1250.20 20 201 4.2E-31 T 09-03-2017 TK78_RS04030 dc85ec27b750b7ea60db65a8a835c569 277 Gene3D G3DSA:1.10.260.40 11 67 1.2E-13 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS04030 dc85ec27b750b7ea60db65a8a835c569 277 Pfam PF13560 Helix-turn-helix domain 11 71 2.8E-13 T 09-03-2017 TK78_RS04030 dc85ec27b750b7ea60db65a8a835c569 277 SMART SM00530 13 68 6.7E-12 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS04030 dc85ec27b750b7ea60db65a8a835c569 277 SUPERFAMILY SSF47413 10 67 2.82E-13 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS30825 aa937f6da34f7f6d69c985037bbc0451 592 SMART SM00327 380 577 3.4E-14 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS30825 aa937f6da34f7f6d69c985037bbc0451 592 Gene3D G3DSA:3.40.50.410 381 580 4.2E-12 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS30825 aa937f6da34f7f6d69c985037bbc0451 592 SUPERFAMILY SSF53300 383 576 9.22E-20 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS30825 aa937f6da34f7f6d69c985037bbc0451 592 Pfam PF00092 von Willebrand factor type A domain 384 575 1.3E-6 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS30825 aa937f6da34f7f6d69c985037bbc0451 592 SUPERFAMILY SSF53850 59 374 5.29E-10 T 09-03-2017 TK78_RS30825 aa937f6da34f7f6d69c985037bbc0451 592 Pfam PF13531 Bacterial extracellular solute-binding protein 59 332 8.5E-36 T 09-03-2017 TK78_RS23500 b9e599df2f106e5d305f5adabd68614d 273 Pfam PF15698 Phosphatase 9 258 1.1E-113 T 09-03-2017 IPR031423 Uncharacterised phosphatase SCO2771 TK78_RS04230 f4e5d280f2c64d7fdcd3112a764f34f6 324 Gene3D G3DSA:3.20.20.60 10 256 6.5E-79 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS04230 f4e5d280f2c64d7fdcd3112a764f34f6 324 PIRSF PIRSF015582 1 323 1.7E-90 T 09-03-2017 IPR011206 Citrate lyase beta subunit-like TK78_RS04230 f4e5d280f2c64d7fdcd3112a764f34f6 324 Pfam PF03328 HpcH/HpaI aldolase/citrate lyase family 15 245 1.9E-45 T 09-03-2017 IPR005000 HpcH/HpaI aldolase/citrate lyase domain GO:0003824 TK78_RS04230 f4e5d280f2c64d7fdcd3112a764f34f6 324 SUPERFAMILY SSF51621 11 256 3.69E-66 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS10930 dbd57abfe50392dfd6f494449dd3ca22 311 Pfam PF02585 GlcNAc-PI de-N-acetylase 10 160 1.7E-25 T 09-03-2017 IPR003737 N-acetylglucosaminyl phosphatidylinositol deacetylase-related Reactome: R-HSA-162710 TK78_RS10930 dbd57abfe50392dfd6f494449dd3ca22 311 TIGRFAM TIGR03445 mycothiol_MshB: N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase 10 292 9.2E-123 T 09-03-2017 IPR017810 Mycothiol biosynthesis protein, MshB GO:0035595 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497 TK78_RS10930 dbd57abfe50392dfd6f494449dd3ca22 311 SUPERFAMILY SSF102588 7 281 7.06E-68 T 09-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 TK78_RS10930 dbd57abfe50392dfd6f494449dd3ca22 311 Hamap MF_01696 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase [mshB]. 9 292 40.676 T 09-03-2017 IPR017810 Mycothiol biosynthesis protein, MshB GO:0035595 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497 TK78_RS10930 dbd57abfe50392dfd6f494449dd3ca22 311 Gene3D G3DSA:3.40.50.10320 6 292 1.4E-90 T 09-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 TK78_RS20280 c1a5f1769903fa726ae2dd7d5987f878 151 SUPERFAMILY SSF54909 61 143 8.58E-18 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS20280 c1a5f1769903fa726ae2dd7d5987f878 151 Gene3D G3DSA:3.30.70.920 54 144 3.2E-23 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS20280 c1a5f1769903fa726ae2dd7d5987f878 151 SMART SM00344 1 108 9.8E-39 T 09-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 TK78_RS20280 c1a5f1769903fa726ae2dd7d5987f878 151 SUPERFAMILY SSF46785 1 60 1.11E-15 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS20280 c1a5f1769903fa726ae2dd7d5987f878 151 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 28 47 4.0E-14 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS20280 c1a5f1769903fa726ae2dd7d5987f878 151 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 17 28 4.0E-14 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS20280 c1a5f1769903fa726ae2dd7d5987f878 151 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 1 17 4.0E-14 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS20280 c1a5f1769903fa726ae2dd7d5987f878 151 Gene3D G3DSA:1.10.10.10 1 52 3.5E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS20280 c1a5f1769903fa726ae2dd7d5987f878 151 Pfam PF13404 AsnC-type helix-turn-helix domain 1 42 9.3E-17 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS20280 c1a5f1769903fa726ae2dd7d5987f878 151 Pfam PF01037 Lrp/AsnC ligand binding domain 67 138 8.2E-18 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS20280 c1a5f1769903fa726ae2dd7d5987f878 151 ProSitePatterns PS00519 AsnC-type HTH domain signature. 19 45 - T 09-03-2017 IPR019885 Transcription regulator HTH, AsnC-type, conserved site TK78_RS12290 7c654c6c4860bd219ce2f45195b9f263 554 Pfam PF03814 Potassium-transporting ATPase A subunit 14 552 2.6E-224 T 09-03-2017 IPR004623 Potassium-transporting ATPase A chain GO:0005886|GO:0006813|GO:0008556 TK78_RS12290 7c654c6c4860bd219ce2f45195b9f263 554 PIRSF PIRSF001294 4 554 3.4E-215 T 09-03-2017 IPR004623 Potassium-transporting ATPase A chain GO:0005886|GO:0006813|GO:0008556 TK78_RS12290 7c654c6c4860bd219ce2f45195b9f263 554 Hamap MF_00275 Potassium-transporting ATPase potassium-binding subunit [kdpA]. 4 554 32.598 T 09-03-2017 IPR004623 Potassium-transporting ATPase A chain GO:0005886|GO:0006813|GO:0008556 TK78_RS12290 7c654c6c4860bd219ce2f45195b9f263 554 TIGRFAM TIGR00680 kdpA: K+-transporting ATPase, A subunit 5 552 1.0E-201 T 09-03-2017 IPR004623 Potassium-transporting ATPase A chain GO:0005886|GO:0006813|GO:0008556 TK78_RS05470 49eb48a0e6dc2a20ee3407cb69356e7d 565 SUPERFAMILY SSF55124 22 172 4.22E-39 T 09-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TK78_RS05470 49eb48a0e6dc2a20ee3407cb69356e7d 565 Gene3D G3DSA:3.30.413.10 173 326 4.8E-44 T 09-03-2017 TK78_RS05470 49eb48a0e6dc2a20ee3407cb69356e7d 565 Gene3D G3DSA:3.30.413.10 423 563 2.9E-37 T 09-03-2017 TK78_RS05470 49eb48a0e6dc2a20ee3407cb69356e7d 565 Pfam PF03460 Nitrite/Sulfite reductase ferredoxin-like half domain 102 164 9.0E-21 T 09-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TK78_RS05470 49eb48a0e6dc2a20ee3407cb69356e7d 565 Pfam PF03460 Nitrite/Sulfite reductase ferredoxin-like half domain 349 414 3.4E-15 T 09-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TK78_RS05470 49eb48a0e6dc2a20ee3407cb69356e7d 565 SUPERFAMILY SSF56014 173 359 2.88E-47 T 09-03-2017 TK78_RS05470 49eb48a0e6dc2a20ee3407cb69356e7d 565 Gene3D G3DSA:3.90.480.10 102 170 5.3E-50 T 09-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TK78_RS05470 49eb48a0e6dc2a20ee3407cb69356e7d 565 Gene3D G3DSA:3.90.480.10 342 417 5.3E-50 T 09-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TK78_RS05470 49eb48a0e6dc2a20ee3407cb69356e7d 565 ProSitePatterns PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. 471 487 - T 09-03-2017 IPR006066 Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TK78_RS05470 49eb48a0e6dc2a20ee3407cb69356e7d 565 PRINTS PR00397 Sirohaem Fe-binding site signature 471 489 1.4E-9 T 09-03-2017 IPR006066 Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TK78_RS05470 49eb48a0e6dc2a20ee3407cb69356e7d 565 PRINTS PR00397 Sirohaem Fe-binding site signature 426 444 1.4E-9 T 09-03-2017 IPR006066 Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TK78_RS05470 49eb48a0e6dc2a20ee3407cb69356e7d 565 SUPERFAMILY SSF56014 422 562 1.26E-36 T 09-03-2017 TK78_RS05470 49eb48a0e6dc2a20ee3407cb69356e7d 565 SUPERFAMILY SSF55124 342 418 4.11E-19 T 09-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TK78_RS05470 49eb48a0e6dc2a20ee3407cb69356e7d 565 Pfam PF01077 Nitrite and sulphite reductase 4Fe-4S domain 173 328 1.6E-40 T 09-03-2017 IPR006067 Nitrite/sulphite reductase 4Fe-4S domain GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TK78_RS05470 49eb48a0e6dc2a20ee3407cb69356e7d 565 Pfam PF01077 Nitrite and sulphite reductase 4Fe-4S domain 426 562 4.6E-10 T 09-03-2017 IPR006067 Nitrite/sulphite reductase 4Fe-4S domain GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TK78_RS22645 0bf7e01d3079f44d8a8114aea6f8d55f 421 Pfam PF02378 Phosphotransferase system, EIIC 27 340 8.2E-76 T 09-03-2017 IPR003352 Phosphotransferase system, EIIC GO:0008982|GO:0009401|GO:0016020 TK78_RS07465 f285e0338abbc88a3620161eb977ff02 313 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 82 263 2.2E-23 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS07465 f285e0338abbc88a3620161eb977ff02 313 TIGRFAM TIGR01726 HEQRo_perm_3TM: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family 61 153 1.7E-15 T 09-03-2017 IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain GO:0005215|GO:0006810|GO:0016021 TK78_RS07465 f285e0338abbc88a3620161eb977ff02 313 Gene3D G3DSA:1.10.3720.10 61 264 1.0E-42 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS07465 f285e0338abbc88a3620161eb977ff02 313 SUPERFAMILY SSF161098 62 249 1.96E-37 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS34540 2caa703e126451188f62bb97d5ed9e4f 381 SUPERFAMILY SSF88659 91 149 2.62E-8 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS34540 2caa703e126451188f62bb97d5ed9e4f 381 Gene3D G3DSA:1.10.10.10 92 148 2.3E-11 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS34540 2caa703e126451188f62bb97d5ed9e4f 381 SUPERFAMILY SSF88946 5 85 7.85E-12 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS34540 2caa703e126451188f62bb97d5ed9e4f 381 Pfam PF08281 Sigma-70, region 4 98 148 7.5E-8 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS34540 2caa703e126451188f62bb97d5ed9e4f 381 Gene3D G3DSA:1.10.1740.10 8 89 1.0E-11 T 09-03-2017 TK78_RS34540 2caa703e126451188f62bb97d5ed9e4f 381 Pfam PF04542 Sigma-70 region 2 10 69 6.0E-8 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS21010 e6ed82accc47a4de78dcf31cf2a0be20 297 Gene3D G3DSA:3.40.50.720 9 233 2.6E-53 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS21010 e6ed82accc47a4de78dcf31cf2a0be20 297 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 134 142 8.4E-8 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS21010 e6ed82accc47a4de78dcf31cf2a0be20 297 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 154 173 8.4E-8 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS21010 e6ed82accc47a4de78dcf31cf2a0be20 297 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 82 93 8.4E-8 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS21010 e6ed82accc47a4de78dcf31cf2a0be20 297 SUPERFAMILY SSF51735 6 264 1.32E-58 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS21010 e6ed82accc47a4de78dcf31cf2a0be20 297 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 10 189 2.2E-5 T 09-03-2017 TK78_RS21010 e6ed82accc47a4de78dcf31cf2a0be20 297 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 128 144 5.9E-18 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS21010 e6ed82accc47a4de78dcf31cf2a0be20 297 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 11 28 5.9E-18 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS21010 e6ed82accc47a4de78dcf31cf2a0be20 297 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 154 173 5.9E-18 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS21010 e6ed82accc47a4de78dcf31cf2a0be20 297 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 82 93 5.9E-18 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS21010 e6ed82accc47a4de78dcf31cf2a0be20 297 Pfam PF00106 short chain dehydrogenase 10 198 9.7E-45 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS21010 e6ed82accc47a4de78dcf31cf2a0be20 297 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 141 169 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS24215 91180bcacb267326b3c6f23d6120cda0 166 Pfam PF06718 Protein of unknown function (DUF1203) 36 164 5.0E-38 T 09-03-2017 IPR009593 Protein of unknown function DUF1203 TK78_RS24215 91180bcacb267326b3c6f23d6120cda0 166 PIRSF PIRSF034110 1 166 1.8E-44 T 09-03-2017 IPR009593 Protein of unknown function DUF1203 TK78_RS11985 0b239ef65a003937e6ac977ca4b4937c 68 Pfam PF13822 Acyl-CoA carboxylase epsilon subunit 2 61 1.3E-19 T 09-03-2017 IPR032716 Acyl-CoA carboxylase epsilon subunit TK78_RS23040 0f8a363681f065e781478da44967d38d 822 Pfam PF01145 SPFH domain / Band 7 family 604 766 2.4E-18 T 09-03-2017 IPR001107 Band 7 domain TK78_RS23040 0f8a363681f065e781478da44967d38d 822 SMART SM00244 597 760 0.0015 T 09-03-2017 IPR001107 Band 7 domain TK78_RS23040 0f8a363681f065e781478da44967d38d 822 SUPERFAMILY SSF117892 635 764 1.23E-8 T 09-03-2017 IPR001107 Band 7 domain TK78_RS16855 7afda9dcd45261d9c53281e13e35a568 164 Pfam PF00392 Bacterial regulatory proteins, gntR family 3 60 3.2E-17 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS16855 7afda9dcd45261d9c53281e13e35a568 164 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 34 50 6.0E-6 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS16855 7afda9dcd45261d9c53281e13e35a568 164 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 20 34 6.0E-6 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS16855 7afda9dcd45261d9c53281e13e35a568 164 Gene3D G3DSA:1.10.10.10 2 65 1.0E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS16855 7afda9dcd45261d9c53281e13e35a568 164 SUPERFAMILY SSF46785 2 64 1.01E-18 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS16855 7afda9dcd45261d9c53281e13e35a568 164 SMART SM00345 1 60 2.8E-14 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS18475 eff36920299bfb2c9b04c71f80313378 475 Gene3D G3DSA:3.50.50.60 117 272 5.7E-19 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS18475 eff36920299bfb2c9b04c71f80313378 475 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 3 22 1.2E-10 T 09-03-2017 TK78_RS18475 eff36920299bfb2c9b04c71f80313378 475 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 169 187 1.2E-10 T 09-03-2017 TK78_RS18475 eff36920299bfb2c9b04c71f80313378 475 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 109 127 1.2E-10 T 09-03-2017 TK78_RS18475 eff36920299bfb2c9b04c71f80313378 475 SUPERFAMILY SSF51905 2 226 1.65E-24 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS18475 eff36920299bfb2c9b04c71f80313378 475 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 2 337 5.6E-41 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS18475 eff36920299bfb2c9b04c71f80313378 475 SUPERFAMILY SSF51905 170 348 1.92E-17 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS18475 eff36920299bfb2c9b04c71f80313378 475 Gene3D G3DSA:3.50.50.60 273 351 6.9E-28 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS18475 eff36920299bfb2c9b04c71f80313378 475 Gene3D G3DSA:3.50.50.60 2 116 6.9E-28 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS04970 5c7998911ada7747ea958bc7cadd1c9a 485 TIGRFAM TIGR03173 pbuX: xanthine permease 47 456 2.7E-156 T 09-03-2017 IPR017588 Uric acid permease UacT-like GO:0006810|GO:0016021 TK78_RS04970 5c7998911ada7747ea958bc7cadd1c9a 485 ProSitePatterns PS01116 Xanthine/uracil permeases family signature. 371 391 - T 09-03-2017 IPR006042 Xanthine/uracil permease GO:0005215|GO:0016020|GO:0055085 Reactome: R-HSA-196836 TK78_RS04970 5c7998911ada7747ea958bc7cadd1c9a 485 Pfam PF00860 Permease family 42 423 7.1E-92 T 09-03-2017 IPR006043 Xanthine/uracil/vitamin C permease GO:0005215|GO:0006810|GO:0016020|GO:0055085 TK78_RS04970 5c7998911ada7747ea958bc7cadd1c9a 485 TIGRFAM TIGR00801 ncs2: uracil-xanthine permease 39 453 1.6E-107 T 09-03-2017 IPR006042 Xanthine/uracil permease GO:0005215|GO:0016020|GO:0055085 Reactome: R-HSA-196836 TK78_RS07365 a031d3fa4380b00919f36ecaed76fc31 241 SMART SM01006 74 122 5.8E-12 T 09-03-2017 IPR019432 Siderophore biosynthesis protein, conserved domain TK78_RS07365 a031d3fa4380b00919f36ecaed76fc31 241 SUPERFAMILY SSF55729 68 235 1.85E-45 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS07365 a031d3fa4380b00919f36ecaed76fc31 241 Gene3D G3DSA:3.40.630.30 69 236 8.9E-49 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS07365 a031d3fa4380b00919f36ecaed76fc31 241 Pfam PF13523 Acetyltransferase (GNAT) domain 78 223 3.6E-48 T 09-03-2017 TK78_RS12575 200ca5df3833590ab9442c9e0afa4467 602 SUPERFAMILY SSF51261 451 594 2.09E-37 T 09-03-2017 IPR011055 Duplicated hybrid motif TK78_RS12575 200ca5df3833590ab9442c9e0afa4467 602 Gene3D G3DSA:2.70.70.10 452 595 4.1E-37 T 09-03-2017 TK78_RS12575 200ca5df3833590ab9442c9e0afa4467 602 Pfam PF01551 Peptidase family M23 497 590 3.7E-25 T 09-03-2017 IPR016047 Peptidase M23 TK78_RS01920 d2213aac57eb1c663a00867b002d76ef 239 Gene3D G3DSA:1.10.357.10 3 177 5.3E-32 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS01920 d2213aac57eb1c663a00867b002d76ef 239 Pfam PF00440 Bacterial regulatory proteins, tetR family 9 55 8.4E-10 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS01920 d2213aac57eb1c663a00867b002d76ef 239 SUPERFAMILY SSF48498 75 175 6.68E-9 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS01920 d2213aac57eb1c663a00867b002d76ef 239 SUPERFAMILY SSF46689 4 68 1.26E-14 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS02740 965cb511c9973c3003c9892167e951c3 253 Pfam PF08281 Sigma-70, region 4 112 162 4.2E-8 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS02740 965cb511c9973c3003c9892167e951c3 253 SUPERFAMILY SSF88659 107 164 9.16E-8 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS02740 965cb511c9973c3003c9892167e951c3 253 Gene3D G3DSA:1.10.1740.10 5 88 2.0E-5 T 09-03-2017 TK78_RS02740 965cb511c9973c3003c9892167e951c3 253 Gene3D G3DSA:1.10.10.10 110 164 8.4E-9 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS29250 dba0561db4f460764e9dfa1dbefa0e7e 409 TIGRFAM TIGR03447 mycothiol_MshC: cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase 2 409 7.4E-205 T 09-03-2017 IPR017812 Mycothiol ligase MshC GO:0010125|GO:0035446 TK78_RS29250 dba0561db4f460764e9dfa1dbefa0e7e 409 Pfam PF01406 tRNA synthetases class I (C) catalytic domain 39 333 1.1E-81 T 09-03-2017 IPR032678 tRNA synthetases class I, catalytic domain KEGG: 00970+6.1.1.16 TK78_RS29250 dba0561db4f460764e9dfa1dbefa0e7e 409 Gene3D G3DSA:3.40.50.620 37 326 5.6E-76 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS29250 dba0561db4f460764e9dfa1dbefa0e7e 409 Hamap MF_01697 L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase [mshC]. 9 409 53.756 T 09-03-2017 IPR017812 Mycothiol ligase MshC GO:0010125|GO:0035446 TK78_RS29250 dba0561db4f460764e9dfa1dbefa0e7e 409 SUPERFAMILY SSF52374 33 333 3.22E-67 T 09-03-2017 TK78_RS29250 dba0561db4f460764e9dfa1dbefa0e7e 409 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 40 51 2.2E-18 T 09-03-2017 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 TK78_RS29250 dba0561db4f460764e9dfa1dbefa0e7e 409 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 76 85 2.2E-18 T 09-03-2017 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 TK78_RS29250 dba0561db4f460764e9dfa1dbefa0e7e 409 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 241 262 2.2E-18 T 09-03-2017 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 TK78_RS29250 dba0561db4f460764e9dfa1dbefa0e7e 409 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 210 228 2.2E-18 T 09-03-2017 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 TK78_RS26385 4e3938ec0cc90eb3dc582a64a6464143 577 SMART SM00642 40 377 1.3E-81 T 09-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 TK78_RS26385 4e3938ec0cc90eb3dc582a64a6464143 577 Gene3D G3DSA:2.60.40.10 484 572 1.7E-30 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS26385 4e3938ec0cc90eb3dc582a64a6464143 577 Gene3D G3DSA:3.20.20.80 35 381 1.1E-102 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS26385 4e3938ec0cc90eb3dc582a64a6464143 577 PRINTS PR00110 Alpha-amylase signature 83 100 3.5E-24 T 09-03-2017 IPR006046 Alpha amylase GO:0003824|GO:0005975|GO:0043169 KEGG: 00500+3.2.1.1|Reactome: R-HSA-189085 TK78_RS26385 4e3938ec0cc90eb3dc582a64a6464143 577 PRINTS PR00110 Alpha-amylase signature 291 303 3.5E-24 T 09-03-2017 IPR006046 Alpha amylase GO:0003824|GO:0005975|GO:0043169 KEGG: 00500+3.2.1.1|Reactome: R-HSA-189085 TK78_RS26385 4e3938ec0cc90eb3dc582a64a6464143 577 PRINTS PR00110 Alpha-amylase signature 204 215 3.5E-24 T 09-03-2017 IPR006046 Alpha amylase GO:0003824|GO:0005975|GO:0043169 KEGG: 00500+3.2.1.1|Reactome: R-HSA-189085 TK78_RS26385 4e3938ec0cc90eb3dc582a64a6464143 577 PRINTS PR00110 Alpha-amylase signature 233 251 3.5E-24 T 09-03-2017 IPR006046 Alpha amylase GO:0003824|GO:0005975|GO:0043169 KEGG: 00500+3.2.1.1|Reactome: R-HSA-189085 TK78_RS26385 4e3938ec0cc90eb3dc582a64a6464143 577 PRINTS PR00110 Alpha-amylase signature 115 126 3.5E-24 T 09-03-2017 IPR006046 Alpha amylase GO:0003824|GO:0005975|GO:0043169 KEGG: 00500+3.2.1.1|Reactome: R-HSA-189085 TK78_RS26385 4e3938ec0cc90eb3dc582a64a6464143 577 SUPERFAMILY SSF51445 38 379 2.52E-82 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS26385 4e3938ec0cc90eb3dc582a64a6464143 577 Pfam PF00128 Alpha amylase, catalytic domain 92 340 5.1E-17 T 09-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 TK78_RS26385 4e3938ec0cc90eb3dc582a64a6464143 577 SMART SM01065 480 572 9.4E-30 T 09-03-2017 IPR002044 Carbohydrate binding module family 20 GO:2001070 TK78_RS26385 4e3938ec0cc90eb3dc582a64a6464143 577 SUPERFAMILY SSF51011 382 462 1.29E-28 T 09-03-2017 TK78_RS26385 4e3938ec0cc90eb3dc582a64a6464143 577 Gene3D G3DSA:2.60.40.1180 382 459 3.7E-31 T 09-03-2017 IPR013780 Glycosyl hydrolase, all-beta TK78_RS26385 4e3938ec0cc90eb3dc582a64a6464143 577 SUPERFAMILY SSF49452 484 575 1.5E-30 T 09-03-2017 IPR013784 Carbohydrate-binding-like fold GO:0030246 TK78_RS26385 4e3938ec0cc90eb3dc582a64a6464143 577 SMART SM00632 386 462 1.8E-40 T 09-03-2017 IPR031319 Alpha-amylase, C-terminal domain Reactome: R-HSA-189085 TK78_RS26385 4e3938ec0cc90eb3dc582a64a6464143 577 Pfam PF02806 Alpha amylase, C-terminal all-beta domain 389 459 4.7E-11 T 09-03-2017 IPR006048 Alpha-amylase/branching enzyme, C-terminal all beta GO:0003824|GO:0005975|GO:0043169 KEGG: 00500+2.4.1.18|MetaCyc: PWY-5067|MetaCyc: PWY-622 TK78_RS26385 4e3938ec0cc90eb3dc582a64a6464143 577 Pfam PF00686 Starch binding domain 484 570 2.1E-29 T 09-03-2017 IPR002044 Carbohydrate binding module family 20 GO:2001070 TK78_RS15990 9dd37fb55d850f4804754dcb4701ffdf 343 ProSitePatterns PS00602 Fructose-bisphosphate aldolase class-II signature 1. 86 97 - T 09-03-2017 IPR000771 Ketose-bisphosphate aldolase, class-II GO:0005975|GO:0008270|GO:0016832 TK78_RS15990 9dd37fb55d850f4804754dcb4701ffdf 343 TIGRFAM TIGR01520 FruBisAldo_II_A: fructose-bisphosphate aldolase, class II 3 340 9.0E-129 T 09-03-2017 IPR006411 Fructose-bisphosphate aldolase, class II, yeast/E. coli subtype GO:0004332|GO:0006096 KEGG: 00010+4.1.2.13|KEGG: 00030+4.1.2.13|KEGG: 00051+4.1.2.13|KEGG: 00680+4.1.2.13|KEGG: 00710+4.1.2.13|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7385 TK78_RS15990 9dd37fb55d850f4804754dcb4701ffdf 343 PIRSF PIRSF001359 5 341 1.7E-62 T 09-03-2017 IPR000771 Ketose-bisphosphate aldolase, class-II GO:0005975|GO:0008270|GO:0016832 TK78_RS15990 9dd37fb55d850f4804754dcb4701ffdf 343 Gene3D G3DSA:3.20.20.70 2 340 3.2E-116 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS15990 9dd37fb55d850f4804754dcb4701ffdf 343 TIGRFAM TIGR00167 cbbA: ketose-bisphosphate aldolase 9 340 3.2E-69 T 09-03-2017 IPR000771 Ketose-bisphosphate aldolase, class-II GO:0005975|GO:0008270|GO:0016832 TK78_RS15990 9dd37fb55d850f4804754dcb4701ffdf 343 SUPERFAMILY SSF51569 3 339 1.01E-94 T 09-03-2017 TK78_RS15990 9dd37fb55d850f4804754dcb4701ffdf 343 Pfam PF01116 Fructose-bisphosphate aldolase class-II 9 339 5.2E-77 T 09-03-2017 IPR000771 Ketose-bisphosphate aldolase, class-II GO:0005975|GO:0008270|GO:0016832 TK78_RS18445 d52fdfbc89b362345802b3cc0e9e0ce0 310 Hamap MF_01057 tRNA (guanine-N(7)-)-methyltransferase [trmB]. 96 310 28.026 T 09-03-2017 IPR003358 tRNA (guanine-N-7) methyltransferase, Trmb type GO:0006400|GO:0008176 Reactome: R-HSA-6782315 TK78_RS18445 d52fdfbc89b362345802b3cc0e9e0ce0 310 SUPERFAMILY SSF53335 87 308 4.43E-32 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS18445 d52fdfbc89b362345802b3cc0e9e0ce0 310 Gene3D G3DSA:3.40.50.150 139 267 9.0E-13 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS18445 d52fdfbc89b362345802b3cc0e9e0ce0 310 Pfam PF02390 Putative methyltransferase 137 304 2.5E-49 T 09-03-2017 IPR003358 tRNA (guanine-N-7) methyltransferase, Trmb type GO:0006400|GO:0008176 Reactome: R-HSA-6782315 TK78_RS18445 d52fdfbc89b362345802b3cc0e9e0ce0 310 TIGRFAM TIGR00091 TIGR00091: tRNA (guanine-N(7)-)-methyltransferase 137 309 1.5E-44 T 09-03-2017 IPR003358 tRNA (guanine-N-7) methyltransferase, Trmb type GO:0006400|GO:0008176 Reactome: R-HSA-6782315 TK78_RS32440 0363ab66e1d481c028ee4f8fb914c090 241 Gene3D G3DSA:3.40.50.150 32 239 3.9E-36 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS32440 0363ab66e1d481c028ee4f8fb914c090 241 Pfam PF08241 Methyltransferase domain 48 140 5.1E-19 T 09-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 TK78_RS32440 0363ab66e1d481c028ee4f8fb914c090 241 SUPERFAMILY SSF53335 33 217 1.18E-37 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS32695 a0f87d2d27c6f8aa12bf2b2d2ca58b48 199 Pfam PF01841 Transglutaminase-like superfamily 29 136 1.5E-11 T 09-03-2017 IPR002931 Transglutaminase-like TK78_RS32695 a0f87d2d27c6f8aa12bf2b2d2ca58b48 199 SUPERFAMILY SSF54001 24 142 2.75E-18 T 09-03-2017 TK78_RS22825 04171ff74b9c7401bc6856b2babbe03a 282 Gene3D G3DSA:1.10.260.40 3 69 4.6E-13 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS22825 04171ff74b9c7401bc6856b2babbe03a 282 SUPERFAMILY SSF47413 5 68 1.91E-7 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS22825 04171ff74b9c7401bc6856b2babbe03a 282 Pfam PF13560 Helix-turn-helix domain 11 70 4.4E-11 T 09-03-2017 TK78_RS22825 04171ff74b9c7401bc6856b2babbe03a 282 SMART SM00530 15 73 9.2E-4 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS14710 1d9942098e77564334c22ae1e6fa0f7f 302 SUPERFAMILY SSF53474 6 281 2.8E-25 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS14710 1d9942098e77564334c22ae1e6fa0f7f 302 Pfam PF12740 Chlorophyllase enzyme 27 142 2.0E-8 T 09-03-2017 IPR017395 Chlorophyllase GO:0015996|GO:0047746 KEGG: 00860+3.1.1.14|MetaCyc: PWY-5098|MetaCyc: PWY-6927|MetaCyc: PWY-7164 TK78_RS14710 1d9942098e77564334c22ae1e6fa0f7f 302 Gene3D G3DSA:3.40.50.1820 10 243 6.6E-26 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS03495 1b275675d34dbfd6e30d57078364fc4f 432 TIGRFAM TIGR00996 Mtu_fam_mce: virulence factor Mce family protein 16 298 1.9E-57 T 09-03-2017 IPR005693 Virulence factor Mce protein TK78_RS03495 1b275675d34dbfd6e30d57078364fc4f 432 Pfam PF02470 MlaD protein 42 118 2.6E-12 T 09-03-2017 IPR003399 Mce/MlaD TK78_RS03495 1b275675d34dbfd6e30d57078364fc4f 432 Pfam PF11887 Cholesterol uptake porter CUP1 of Mce4, putative 148 421 5.0E-72 T 09-03-2017 IPR024516 Mammalian cell entry, C-terminal TK78_RS27210 84c5a433f7e0145b59581278e4f73f96 417 Gene3D G3DSA:3.40.50.1010 3 171 4.8E-16 T 09-03-2017 IPR029060 PIN domain-like TK78_RS27210 84c5a433f7e0145b59581278e4f73f96 417 Pfam PF01936 NYN domain 32 166 3.5E-11 T 09-03-2017 IPR021139 NYN domain, limkain-b1-type TK78_RS08645 2925f3ebc4578fcfb807efc50a4d06c1 334 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C 35 70 9.2E-8 T 09-03-2017 IPR025966 Oligopeptide transport permease C-like, N-terminal domain TK78_RS08645 2925f3ebc4578fcfb807efc50a4d06c1 334 SUPERFAMILY SSF161098 89 274 1.27E-18 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS08645 2925f3ebc4578fcfb807efc50a4d06c1 334 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 112 289 2.6E-18 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS08645 2925f3ebc4578fcfb807efc50a4d06c1 334 Gene3D G3DSA:1.10.3720.10 84 286 1.2E-16 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS14145 2a1bb8426702b2826fa5b9c13e4669fb 398 SUPERFAMILY SSF55681 2 246 1.13E-59 T 09-03-2017 TK78_RS14145 2a1bb8426702b2826fa5b9c13e4669fb 398 PRINTS PR00980 Alanyl-tRNA synthetase signature 227 240 2.0E-21 T 09-03-2017 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7 TK78_RS14145 2a1bb8426702b2826fa5b9c13e4669fb 398 PRINTS PR00980 Alanyl-tRNA synthetase signature 294 307 2.0E-21 T 09-03-2017 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7 TK78_RS14145 2a1bb8426702b2826fa5b9c13e4669fb 398 PRINTS PR00980 Alanyl-tRNA synthetase signature 270 286 2.0E-21 T 09-03-2017 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7 TK78_RS14145 2a1bb8426702b2826fa5b9c13e4669fb 398 PRINTS PR00980 Alanyl-tRNA synthetase signature 200 211 2.0E-21 T 09-03-2017 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7 TK78_RS14145 2a1bb8426702b2826fa5b9c13e4669fb 398 PRINTS PR00980 Alanyl-tRNA synthetase signature 70 81 2.0E-21 T 09-03-2017 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7 TK78_RS14145 2a1bb8426702b2826fa5b9c13e4669fb 398 Pfam PF01411 tRNA synthetases class II (A) 8 396 7.6E-81 T 09-03-2017 IPR018164 Alanyl-tRNA synthetase, class IIc, N-terminal GO:0000166|GO:0004813|GO:0005524|GO:0006419 KEGG: 00970+6.1.1.7 TK78_RS14145 2a1bb8426702b2826fa5b9c13e4669fb 398 SUPERFAMILY SSF101353 248 397 7.85E-32 T 09-03-2017 IPR018162 Alanine-tRNA ligase, class IIc, anti-codon-binding domain GO:0000166|GO:0004813|GO:0005524|GO:0005737|GO:0006419 KEGG: 00970+6.1.1.7 TK78_RS14145 2a1bb8426702b2826fa5b9c13e4669fb 398 Gene3D G3DSA:3.30.930.10 1 242 6.2E-60 T 09-03-2017 TK78_RS27800 3827b0705da9c7727eb00727b438fbfc 192 Gene3D G3DSA:2.60.60.30 21 181 4.9E-47 T 09-03-2017 TK78_RS27800 3827b0705da9c7727eb00727b438fbfc 192 Pfam PF02342 TerD domain 2 183 1.6E-44 T 09-03-2017 IPR003325 TerD domain GO:0006950 TK78_RS06830 0ee20ed5da074b2c2f2e9a9660e9545c 943 Gene3D G3DSA:3.40.50.300 185 289 7.2E-6 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06830 0ee20ed5da074b2c2f2e9a9660e9545c 943 SUPERFAMILY SSF52540 170 400 1.09E-23 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06830 0ee20ed5da074b2c2f2e9a9660e9545c 943 Pfam PF00931 NB-ARC domain 184 378 1.3E-7 T 09-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 TK78_RS18490 3d1cd14c8e453f8f2d127464ed3c0a97 185 Pfam PF12802 MarR family 58 117 6.7E-10 T 09-03-2017 TK78_RS18490 3d1cd14c8e453f8f2d127464ed3c0a97 185 PRINTS PR00598 Bacterial regulatory protein MarR family signature 80 96 2.7E-9 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS18490 3d1cd14c8e453f8f2d127464ed3c0a97 185 PRINTS PR00598 Bacterial regulatory protein MarR family signature 116 132 2.7E-9 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS18490 3d1cd14c8e453f8f2d127464ed3c0a97 185 PRINTS PR00598 Bacterial regulatory protein MarR family signature 97 112 2.7E-9 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS18490 3d1cd14c8e453f8f2d127464ed3c0a97 185 PRINTS PR00598 Bacterial regulatory protein MarR family signature 146 166 2.7E-9 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS18490 3d1cd14c8e453f8f2d127464ed3c0a97 185 SUPERFAMILY SSF46785 26 170 3.76E-31 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS18490 3d1cd14c8e453f8f2d127464ed3c0a97 185 ProSitePatterns PS00519 AsnC-type HTH domain signature. 81 107 - T 09-03-2017 IPR019885 Transcription regulator HTH, AsnC-type, conserved site TK78_RS18490 3d1cd14c8e453f8f2d127464ed3c0a97 185 Gene3D G3DSA:1.10.10.10 22 172 3.1E-35 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS18490 3d1cd14c8e453f8f2d127464ed3c0a97 185 SMART SM00347 53 156 1.2E-19 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS18490 3d1cd14c8e453f8f2d127464ed3c0a97 185 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 90 109 4.8E-5 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS18490 3d1cd14c8e453f8f2d127464ed3c0a97 185 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 79 90 4.8E-5 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS20565 db2c0f7d3e5c256ea9fb8c76a3e01768 349 Gene3D G3DSA:3.20.20.100 9 317 9.9E-96 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS20565 db2c0f7d3e5c256ea9fb8c76a3e01768 349 SUPERFAMILY SSF51430 1 316 6.15E-100 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS20565 db2c0f7d3e5c256ea9fb8c76a3e01768 349 PRINTS PR00069 Aldo-keto reductase signature 136 153 1.2E-7 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS20565 db2c0f7d3e5c256ea9fb8c76a3e01768 349 PRINTS PR00069 Aldo-keto reductase signature 41 65 1.2E-7 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS20565 db2c0f7d3e5c256ea9fb8c76a3e01768 349 PRINTS PR00069 Aldo-keto reductase signature 105 123 1.2E-7 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS20565 db2c0f7d3e5c256ea9fb8c76a3e01768 349 Pfam PF00248 Aldo/keto reductase family 17 315 1.2E-73 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS21360 a9cc1dd2b38fa6affc28a539bd10e395 325 SMART SM01400 12 128 5.4E-70 T 09-03-2017 TK78_RS21360 a9cc1dd2b38fa6affc28a539bd10e395 325 Gene3D G3DSA:3.40.50.2020 9 167 1.4E-68 T 09-03-2017 IPR029057 Phosphoribosyltransferase-like TK78_RS21360 a9cc1dd2b38fa6affc28a539bd10e395 325 Gene3D G3DSA:3.40.50.2020 168 293 9.0E-46 T 09-03-2017 IPR029057 Phosphoribosyltransferase-like TK78_RS21360 a9cc1dd2b38fa6affc28a539bd10e395 325 Pfam PF13793 N-terminal domain of ribose phosphate pyrophosphokinase 12 128 3.1E-44 T 09-03-2017 IPR029099 Ribose-phosphate pyrophosphokinase, N-terminal domain KEGG: 00030+2.7.6.1|KEGG: 00230+2.7.6.1 TK78_RS21360 a9cc1dd2b38fa6affc28a539bd10e395 325 SUPERFAMILY SSF53271 77 313 2.02E-61 T 09-03-2017 IPR029057 Phosphoribosyltransferase-like TK78_RS21360 a9cc1dd2b38fa6affc28a539bd10e395 325 Hamap MF_00583_B Ribose-phosphate pyrophosphokinase [prs]. 12 322 46.815 T 09-03-2017 IPR005946 Ribose-phosphate diphosphokinase GO:0000287|GO:0004749|GO:0009165 KEGG: 00030+2.7.6.1|KEGG: 00230+2.7.6.1 TK78_RS21360 a9cc1dd2b38fa6affc28a539bd10e395 325 TIGRFAM TIGR01251 ribP_PPkin: ribose-phosphate diphosphokinase 13 322 6.6E-113 T 09-03-2017 IPR005946 Ribose-phosphate diphosphokinase GO:0000287|GO:0004749|GO:0009165 KEGG: 00030+2.7.6.1|KEGG: 00230+2.7.6.1 TK78_RS21360 a9cc1dd2b38fa6affc28a539bd10e395 325 Pfam PF14572 Phosphoribosyl synthetase-associated domain 215 321 2.4E-22 T 09-03-2017 IPR005946 Ribose-phosphate diphosphokinase GO:0000287|GO:0004749|GO:0009165 KEGG: 00030+2.7.6.1|KEGG: 00230+2.7.6.1 TK78_RS21360 a9cc1dd2b38fa6affc28a539bd10e395 325 ProSitePatterns PS00114 Phosphoribosyl pyrophosphate synthase signature. 136 151 - T 09-03-2017 IPR000842 Phosphoribosyl pyrophosphate synthetase, conserved site GO:0000287|GO:0004749|GO:0009156|GO:0044249 KEGG: 00030+2.7.6.1|KEGG: 00230+2.7.6.1|Reactome: R-HSA-73843 TK78_RS18320 f5157b35e4c285e22c9264624bbe8bb7 267 Pfam PF13462 Thioredoxin 83 247 3.8E-30 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS18320 f5157b35e4c285e22c9264624bbe8bb7 267 Gene3D G3DSA:3.40.30.10 80 251 2.6E-44 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS18320 f5157b35e4c285e22c9264624bbe8bb7 267 SUPERFAMILY SSF52833 74 247 2.14E-39 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS02205 5296c3b9199fade3329eedc407bb12a9 222 Pfam PF01127 Succinate dehydrogenase/Fumarate reductase transmembrane subunit 94 208 1.2E-6 T 09-03-2017 IPR000701 Succinate dehydrogenase/Fumarate reductase, transmembrane subunit GO:0016627 Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS02205 5296c3b9199fade3329eedc407bb12a9 222 SUPERFAMILY SSF81343 3 221 7.85E-54 T 09-03-2017 TK78_RS02205 5296c3b9199fade3329eedc407bb12a9 222 TIGRFAM TIGR02046 sdhC_b558_fam: succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family 8 221 7.9E-76 T 09-03-2017 IPR011138 Succinate dehydrogenase cytochrome b558 subunit TK78_RS02205 5296c3b9199fade3329eedc407bb12a9 222 Gene3D G3DSA:1.20.950.10 17 212 4.9E-12 T 09-03-2017 TK78_RS10970 0eee2c133fdea7cb70729ba59f07014d 544 Gene3D G3DSA:3.90.76.10 51 207 6.9E-35 T 09-03-2017 TK78_RS10970 0eee2c133fdea7cb70729ba59f07014d 544 PIRSF PIRSF002741 5 541 2.4E-62 T 09-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 TK78_RS10970 0eee2c133fdea7cb70729ba59f07014d 544 Gene3D G3DSA:3.40.190.10 208 323 1.8E-26 T 09-03-2017 TK78_RS10970 0eee2c133fdea7cb70729ba59f07014d 544 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 83 464 1.9E-47 T 09-03-2017 IPR000914 Solute-binding protein family 5 domain TK78_RS10970 0eee2c133fdea7cb70729ba59f07014d 544 Gene3D G3DSA:3.10.105.10 324 515 3.4E-38 T 09-03-2017 TK78_RS10970 0eee2c133fdea7cb70729ba59f07014d 544 SUPERFAMILY SSF53850 39 543 2.35E-93 T 09-03-2017 TK78_RS25170 39b8ec9141295e65a6f3107ba1dafb9a 388 Gene3D G3DSA:2.120.10.30 179 194 1.5E-9 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS25170 39b8ec9141295e65a6f3107ba1dafb9a 388 Gene3D G3DSA:2.120.10.30 271 371 1.5E-9 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS25170 39b8ec9141295e65a6f3107ba1dafb9a 388 Pfam PF05787 Bacterial protein of unknown function (DUF839) 152 250 1.4E-12 T 09-03-2017 IPR008557 Protein of unknown function DUF839 TK78_RS25170 39b8ec9141295e65a6f3107ba1dafb9a 388 Pfam PF07676 WD40-like Beta Propeller Repeat 347 374 2.2E-8 T 09-03-2017 IPR011659 WD40-like Beta Propeller TK78_RS25170 39b8ec9141295e65a6f3107ba1dafb9a 388 SUPERFAMILY SSF63825 151 210 9.68E-16 T 09-03-2017 TK78_RS25170 39b8ec9141295e65a6f3107ba1dafb9a 388 SUPERFAMILY SSF63825 253 368 9.68E-16 T 09-03-2017 TK78_RS12805 195e5369ec4058b66fa4766df5a96e45 411 Pfam PF13649 Methyltransferase domain 120 187 1.5E-7 T 09-03-2017 TK78_RS12805 195e5369ec4058b66fa4766df5a96e45 411 SUPERFAMILY SSF53335 84 246 7.21E-28 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS12805 195e5369ec4058b66fa4766df5a96e45 411 Gene3D G3DSA:3.40.50.150 86 195 1.2E-18 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS08870 2b6ebc0d28ea7d51679eb4e24b698d28 342 Pfam PF01717 Cobalamin-independent synthase, Catalytic domain 11 335 3.8E-14 T 09-03-2017 IPR002629 Cobalamin-independent methionine synthase MetE, C-terminal/archaeal GO:0003871|GO:0008270|GO:0009086 KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6936|MetaCyc: PWY-702 TK78_RS08870 2b6ebc0d28ea7d51679eb4e24b698d28 342 SUPERFAMILY SSF51726 61 338 7.46E-29 T 09-03-2017 TK78_RS08870 2b6ebc0d28ea7d51679eb4e24b698d28 342 Gene3D G3DSA:3.20.20.210 84 339 2.6E-13 T 09-03-2017 TK78_RS08335 e2a25bfd2d1870aa8b7e28333a211c86 336 PIRSF PIRSF000114 2 335 1.0E-97 T 09-03-2017 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|Reactome: R-HSA-1483166|Reactome: R-HSA-75109 TK78_RS08335 e2a25bfd2d1870aa8b7e28333a211c86 336 Gene3D G3DSA:1.10.1040.10 187 329 2.9E-54 T 09-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 TK78_RS08335 e2a25bfd2d1870aa8b7e28333a211c86 336 Gene3D G3DSA:3.40.50.720 4 186 9.3E-68 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS08335 e2a25bfd2d1870aa8b7e28333a211c86 336 Pfam PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 183 321 1.2E-48 T 09-03-2017 IPR006109 Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal GO:0004367|GO:0005975|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|Reactome: R-HSA-1483166|Reactome: R-HSA-75109 TK78_RS08335 e2a25bfd2d1870aa8b7e28333a211c86 336 SUPERFAMILY SSF48179 182 334 1.09E-53 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS08335 e2a25bfd2d1870aa8b7e28333a211c86 336 Hamap MF_00394 Glycerol-3-phosphate dehydrogenase [NAD(P)+] [gpsA]. 5 325 37.885 T 09-03-2017 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|Reactome: R-HSA-1483166|Reactome: R-HSA-75109 TK78_RS08335 e2a25bfd2d1870aa8b7e28333a211c86 336 SUPERFAMILY SSF51735 5 183 7.46E-54 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS08335 e2a25bfd2d1870aa8b7e28333a211c86 336 ProSitePatterns PS00957 NAD-dependent glycerol-3-phosphate dehydrogenase signature. 191 212 - T 09-03-2017 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|Reactome: R-HSA-1483166|Reactome: R-HSA-75109 TK78_RS08335 e2a25bfd2d1870aa8b7e28333a211c86 336 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 241 258 1.2E-43 T 09-03-2017 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|Reactome: R-HSA-1483166|Reactome: R-HSA-75109 TK78_RS08335 e2a25bfd2d1870aa8b7e28333a211c86 336 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 59 86 1.2E-43 T 09-03-2017 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|Reactome: R-HSA-1483166|Reactome: R-HSA-75109 TK78_RS08335 e2a25bfd2d1870aa8b7e28333a211c86 336 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 9 26 1.2E-43 T 09-03-2017 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|Reactome: R-HSA-1483166|Reactome: R-HSA-75109 TK78_RS08335 e2a25bfd2d1870aa8b7e28333a211c86 336 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 136 156 1.2E-43 T 09-03-2017 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|Reactome: R-HSA-1483166|Reactome: R-HSA-75109 TK78_RS08335 e2a25bfd2d1870aa8b7e28333a211c86 336 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 176 200 1.2E-43 T 09-03-2017 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|Reactome: R-HSA-1483166|Reactome: R-HSA-75109 TK78_RS08335 e2a25bfd2d1870aa8b7e28333a211c86 336 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 201 225 1.2E-43 T 09-03-2017 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|Reactome: R-HSA-1483166|Reactome: R-HSA-75109 TK78_RS08335 e2a25bfd2d1870aa8b7e28333a211c86 336 Pfam PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 7 163 5.3E-52 T 09-03-2017 IPR011128 Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal GO:0016616|GO:0046168|GO:0051287|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|Reactome: R-HSA-1483166|Reactome: R-HSA-75109 TK78_RS28060 34139c4516768df4b8fb2c5473a67639 237 SUPERFAMILY SSF54909 162 212 3.0E-7 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS28060 34139c4516768df4b8fb2c5473a67639 237 Pfam PF03992 Antibiotic biosynthesis monooxygenase 129 197 6.4E-11 T 09-03-2017 IPR007138 Antibiotic biosynthesis monooxygenase domain TK78_RS28060 34139c4516768df4b8fb2c5473a67639 237 SUPERFAMILY SSF54909 28 92 2.84E-8 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS28060 34139c4516768df4b8fb2c5473a67639 237 Gene3D G3DSA:3.30.70.900 23 114 1.4E-23 T 09-03-2017 TK78_RS28060 34139c4516768df4b8fb2c5473a67639 237 Gene3D G3DSA:3.30.70.900 123 231 9.0E-31 T 09-03-2017 TK78_RS03120 8f8c204e277ad5e59b726405b2cca884 202 Gene3D G3DSA:1.10.260.40 15 84 9.6E-20 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS03120 8f8c204e277ad5e59b726405b2cca884 202 SUPERFAMILY SSF47413 12 79 6.44E-17 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS03120 8f8c204e277ad5e59b726405b2cca884 202 SMART SM00530 18 73 5.3E-17 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS03120 8f8c204e277ad5e59b726405b2cca884 202 Pfam PF07883 Cupin domain 114 181 8.9E-14 T 09-03-2017 IPR013096 Cupin 2, conserved barrel TK78_RS03120 8f8c204e277ad5e59b726405b2cca884 202 Gene3D G3DSA:2.60.120.10 85 184 1.6E-18 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS03120 8f8c204e277ad5e59b726405b2cca884 202 Pfam PF13560 Helix-turn-helix domain 16 73 6.6E-17 T 09-03-2017 TK78_RS03120 8f8c204e277ad5e59b726405b2cca884 202 SUPERFAMILY SSF51182 78 183 6.8E-23 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS32705 aaf3a393e07faf90509aee35735532d2 108 Gene3D G3DSA:3.40.30.10 18 99 1.5E-12 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS32705 aaf3a393e07faf90509aee35735532d2 108 Pfam PF00085 Thioredoxin 22 94 3.0E-7 T 09-03-2017 IPR013766 Thioredoxin domain GO:0045454 TK78_RS32705 aaf3a393e07faf90509aee35735532d2 108 SUPERFAMILY SSF52833 19 98 2.7E-14 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS11455 fd93854daa717efb8d46a33e49122cf2 635 SUPERFAMILY SSF55874 541 629 5.83E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS11455 fd93854daa717efb8d46a33e49122cf2 635 Pfam PF13581 Histidine kinase-like ATPase domain 526 614 2.4E-10 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS11455 fd93854daa717efb8d46a33e49122cf2 635 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 315 507 3.2E-54 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS11455 fd93854daa717efb8d46a33e49122cf2 635 SUPERFAMILY SSF55781 211 275 2.35E-6 T 09-03-2017 IPR029016 GAF domain-like TK78_RS11455 fd93854daa717efb8d46a33e49122cf2 635 SMART SM00331 289 506 1.8E-38 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS11455 fd93854daa717efb8d46a33e49122cf2 635 Gene3D G3DSA:3.30.450.40 146 265 2.1E-22 T 09-03-2017 IPR029016 GAF domain-like TK78_RS11455 fd93854daa717efb8d46a33e49122cf2 635 Gene3D G3DSA:3.30.450.40 74 110 2.1E-22 T 09-03-2017 IPR029016 GAF domain-like TK78_RS11455 fd93854daa717efb8d46a33e49122cf2 635 SUPERFAMILY SSF81606 303 507 3.4E-9 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS32310 093c7a5a33cc62c39d5fb3319ac13229 245 Pfam PF13185 GAF domain 22 160 6.9E-13 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS32310 093c7a5a33cc62c39d5fb3319ac13229 245 SMART SM01012 172 227 1.9E-20 T 09-03-2017 IPR005561 ANTAR domain GO:0003723 TK78_RS32310 093c7a5a33cc62c39d5fb3319ac13229 245 SUPERFAMILY SSF55781 24 169 2.09E-21 T 09-03-2017 IPR029016 GAF domain-like TK78_RS32310 093c7a5a33cc62c39d5fb3319ac13229 245 SMART SM00065 23 170 8.7E-5 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS32310 093c7a5a33cc62c39d5fb3319ac13229 245 Gene3D G3DSA:3.30.450.40 14 170 2.6E-22 T 09-03-2017 IPR029016 GAF domain-like TK78_RS32310 093c7a5a33cc62c39d5fb3319ac13229 245 Pfam PF03861 ANTAR domain 174 227 3.0E-18 T 09-03-2017 IPR005561 ANTAR domain GO:0003723 TK78_RS32310 093c7a5a33cc62c39d5fb3319ac13229 245 PIRSF PIRSF036625 13 239 1.7E-51 T 09-03-2017 IPR012074 GAF-ANTAR transcription anti-termination regulator, putative TK78_RS32310 093c7a5a33cc62c39d5fb3319ac13229 245 Gene3D G3DSA:1.10.10.10 174 230 5.3E-16 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32310 093c7a5a33cc62c39d5fb3319ac13229 245 SUPERFAMILY SSF52172 157 226 1.24E-7 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS08315 b106e9d5ee893dada8a82e2f89b7a577 326 Gene3D G3DSA:3.90.650.10 151 316 1.9E-50 T 09-03-2017 IPR010918 AIR synthase-related protein, C-terminal domain TK78_RS08315 b106e9d5ee893dada8a82e2f89b7a577 326 Hamap MF_02128 Thiamine-monophosphate kinase [thiL]. 8 313 29.183 T 09-03-2017 IPR006283 Thiamine-monophosphate kinase GO:0009030|GO:0009228 KEGG: 00730+2.7.4.16|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6896|MetaCyc: PWY-6897 TK78_RS08315 b106e9d5ee893dada8a82e2f89b7a577 326 Pfam PF02769 AIR synthase related protein, C-terminal domain 156 243 5.3E-6 T 09-03-2017 IPR010918 AIR synthase-related protein, C-terminal domain TK78_RS08315 b106e9d5ee893dada8a82e2f89b7a577 326 Pfam PF00586 AIR synthase related protein, N-terminal domain 33 142 9.6E-22 T 09-03-2017 IPR016188 PurM-like, N-terminal domain TK78_RS08315 b106e9d5ee893dada8a82e2f89b7a577 326 SUPERFAMILY SSF55326 5 142 1.41E-34 T 09-03-2017 TK78_RS08315 b106e9d5ee893dada8a82e2f89b7a577 326 SUPERFAMILY SSF56042 148 296 1.52E-32 T 09-03-2017 IPR010918 AIR synthase-related protein, C-terminal domain TK78_RS08315 b106e9d5ee893dada8a82e2f89b7a577 326 PIRSF PIRSF005303 4 316 1.4E-90 T 09-03-2017 IPR006283 Thiamine-monophosphate kinase GO:0009030|GO:0009228 KEGG: 00730+2.7.4.16|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6896|MetaCyc: PWY-6897 TK78_RS08315 b106e9d5ee893dada8a82e2f89b7a577 326 TIGRFAM TIGR01379 thiL: thiamine-phosphate kinase 9 316 1.9E-85 T 09-03-2017 IPR006283 Thiamine-monophosphate kinase GO:0009030|GO:0009228 KEGG: 00730+2.7.4.16|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6896|MetaCyc: PWY-6897 TK78_RS08315 b106e9d5ee893dada8a82e2f89b7a577 326 Gene3D G3DSA:3.30.1330.10 4 145 1.4E-45 T 09-03-2017 IPR016188 PurM-like, N-terminal domain TK78_RS20095 b5c2a634853f9499d604bc6fc3ef0f27 403 Gene3D G3DSA:3.30.870.10 242 374 5.1E-32 T 09-03-2017 TK78_RS20095 b5c2a634853f9499d604bc6fc3ef0f27 403 Pfam PF13091 PLD-like domain 58 186 1.2E-12 T 09-03-2017 IPR025202 Phospholipase D-like domain Reactome: R-HSA-1483148 TK78_RS20095 b5c2a634853f9499d604bc6fc3ef0f27 403 Pfam PF13091 PLD-like domain 246 370 3.4E-24 T 09-03-2017 IPR025202 Phospholipase D-like domain Reactome: R-HSA-1483148 TK78_RS20095 b5c2a634853f9499d604bc6fc3ef0f27 403 SUPERFAMILY SSF56024 37 228 9.87E-41 T 09-03-2017 TK78_RS20095 b5c2a634853f9499d604bc6fc3ef0f27 403 Gene3D G3DSA:3.30.870.10 35 228 6.8E-40 T 09-03-2017 TK78_RS20095 b5c2a634853f9499d604bc6fc3ef0f27 403 SMART SM00155 139 166 7.3 T 09-03-2017 IPR001736 Phospholipase D/Transphosphatidylase GO:0003824 Reactome: R-HSA-1483148 TK78_RS20095 b5c2a634853f9499d604bc6fc3ef0f27 403 SMART SM00155 316 343 0.26 T 09-03-2017 IPR001736 Phospholipase D/Transphosphatidylase GO:0003824 Reactome: R-HSA-1483148 TK78_RS20095 b5c2a634853f9499d604bc6fc3ef0f27 403 SUPERFAMILY SSF56024 216 387 3.14E-34 T 09-03-2017 TK78_RS26400 e7a4ef0357ee0add7c7da165c0a368a0 234 Gene3D G3DSA:3.20.180.10 135 225 9.1E-10 T 09-03-2017 IPR019595 Domain of unknown function DUF2470 TK78_RS26400 e7a4ef0357ee0add7c7da165c0a368a0 234 Pfam PF10615 Protein of unknown function (DUF2470) 141 218 3.6E-8 T 09-03-2017 IPR019595 Domain of unknown function DUF2470 TK78_RS26400 e7a4ef0357ee0add7c7da165c0a368a0 234 SUPERFAMILY SSF50475 121 224 5.89E-11 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS08290 5b7715e47912afdd7883688aa2c69d58 194 ProSitePatterns PS00092 N-6 Adenine-specific DNA methylases signature. 119 125 - T 09-03-2017 IPR002052 DNA methylase, N-6 adenine-specific, conserved site GO:0003676|GO:0008168|GO:0032259 TK78_RS08290 5b7715e47912afdd7883688aa2c69d58 194 Pfam PF03602 Conserved hypothetical protein 95 2 183 1.5E-50 T 09-03-2017 TK78_RS08290 5b7715e47912afdd7883688aa2c69d58 194 TIGRFAM TIGR00095 TIGR00095: 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD 2 183 3.4E-42 T 09-03-2017 IPR004398 RNA methyltransferase, RsmD GO:0008168|GO:0031167 KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 TK78_RS08290 5b7715e47912afdd7883688aa2c69d58 194 SUPERFAMILY SSF53335 2 181 3.04E-40 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS08290 5b7715e47912afdd7883688aa2c69d58 194 PIRSF PIRSF004553 1 187 5.6E-49 T 09-03-2017 IPR004398 RNA methyltransferase, RsmD GO:0008168|GO:0031167 KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 TK78_RS08290 5b7715e47912afdd7883688aa2c69d58 194 Gene3D G3DSA:3.40.50.150 1 186 3.3E-56 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS25310 2ac0156b78b64bb7015376c6df0ac7cc 384 TIGRFAM TIGR01869 casC_Cse4: CRISPR-associated protein Cas7/Cse4/CasC, subtype I-E/ECOLI 6 323 4.4E-89 T 09-03-2017 IPR010148 CRISPR-associated protein, CT1975 TK78_RS25310 2ac0156b78b64bb7015376c6df0ac7cc 384 Pfam PF09344 CT1975-like protein 7 347 2.2E-115 T 09-03-2017 IPR010148 CRISPR-associated protein, CT1975 TK78_RS04830 496f00a22e76bf7ef0e03b164cf9e3c8 252 SMART SM00345 26 85 9.3E-15 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS04830 496f00a22e76bf7ef0e03b164cf9e3c8 252 Gene3D G3DSA:1.10.10.10 15 86 1.1E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS04830 496f00a22e76bf7ef0e03b164cf9e3c8 252 SMART SM00866 105 243 6.4E-35 T 09-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 TK78_RS04830 496f00a22e76bf7ef0e03b164cf9e3c8 252 Gene3D G3DSA:3.40.1410.10 87 246 2.8E-49 T 09-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain TK78_RS04830 496f00a22e76bf7ef0e03b164cf9e3c8 252 SUPERFAMILY SSF46785 15 89 2.52E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS04830 496f00a22e76bf7ef0e03b164cf9e3c8 252 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 45 59 2.4E-6 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS04830 496f00a22e76bf7ef0e03b164cf9e3c8 252 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 59 75 2.4E-6 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS04830 496f00a22e76bf7ef0e03b164cf9e3c8 252 SUPERFAMILY SSF64288 73 247 7.69E-46 T 09-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain TK78_RS04830 496f00a22e76bf7ef0e03b164cf9e3c8 252 Pfam PF07702 UTRA domain 106 242 3.5E-38 T 09-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 TK78_RS04830 496f00a22e76bf7ef0e03b164cf9e3c8 252 Pfam PF00392 Bacterial regulatory proteins, gntR family 23 85 6.8E-15 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS17085 3512688d8da2289b97b7c06d4f421893 359 Hamap MF_01513 Putative phenylalanine aminotransferase [pat]. 8 357 49.663 T 09-03-2017 IPR024892 Putative phenylalanine aminotransferase TK78_RS17085 3512688d8da2289b97b7c06d4f421893 359 TIGRFAM TIGR01141 hisC: histidinol-phosphate transaminase 10 352 5.5E-88 T 09-03-2017 IPR005861 Histidinol-phosphate aminotransferase family GO:0000105|GO:0004400 KEGG: 00340+2.6.1.9|KEGG: 00350+2.6.1.9|KEGG: 00360+2.6.1.9|KEGG: 00400+2.6.1.9|KEGG: 00401+2.6.1.9|KEGG: 00960+2.6.1.9 TK78_RS17085 3512688d8da2289b97b7c06d4f421893 359 Gene3D G3DSA:3.90.1150.10 246 354 3.9E-30 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS17085 3512688d8da2289b97b7c06d4f421893 359 SUPERFAMILY SSF53383 26 350 1.67E-75 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS17085 3512688d8da2289b97b7c06d4f421893 359 Hamap MF_01023 Histidinol-phosphate aminotransferase [hisC]. 7 356 49.816 T 09-03-2017 IPR005861 Histidinol-phosphate aminotransferase family GO:0000105|GO:0004400 KEGG: 00340+2.6.1.9|KEGG: 00350+2.6.1.9|KEGG: 00360+2.6.1.9|KEGG: 00400+2.6.1.9|KEGG: 00401+2.6.1.9|KEGG: 00960+2.6.1.9 TK78_RS17085 3512688d8da2289b97b7c06d4f421893 359 Gene3D G3DSA:3.40.640.10 51 245 6.2E-45 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS17085 3512688d8da2289b97b7c06d4f421893 359 Pfam PF00155 Aminotransferase class I and II 33 340 1.1E-48 T 09-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TK78_RS17085 3512688d8da2289b97b7c06d4f421893 359 ProSitePatterns PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 220 229 - T 09-03-2017 IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site GO:0008152|GO:0016740 TK78_RS22605 70241e5a4f0076168316f45105fab143 336 Gene3D G3DSA:3.40.50.1980 59 191 1.3E-16 T 09-03-2017 TK78_RS22605 70241e5a4f0076168316f45105fab143 336 Pfam PF01497 Periplasmic binding protein 63 304 3.9E-35 T 09-03-2017 IPR002491 ABC transporter periplasmic binding domain GO:0005488 TK78_RS22605 70241e5a4f0076168316f45105fab143 336 SUPERFAMILY SSF53807 59 328 6.67E-51 T 09-03-2017 TK78_RS22605 70241e5a4f0076168316f45105fab143 336 Gene3D G3DSA:3.40.50.1980 197 329 2.2E-32 T 09-03-2017 TK78_RS08500 54c543c94f23b47e8c8a33af319aa539 205 SUPERFAMILY SSF101874 29 201 2.09E-59 T 09-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like TK78_RS08500 54c543c94f23b47e8c8a33af319aa539 205 Gene3D G3DSA:2.40.128.110 29 201 9.6E-63 T 09-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like TK78_RS08500 54c543c94f23b47e8c8a33af319aa539 205 SMART SM00867 30 199 4.9E-73 T 09-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like TK78_RS08500 54c543c94f23b47e8c8a33af319aa539 205 Pfam PF04264 YceI-like domain 31 197 6.8E-47 T 09-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like TK78_RS13375 d552b419aa8d64a89013dceaa6f6f5fb 152 Pfam PF01741 Large-conductance mechanosensitive channel, MscL 2 121 4.4E-29 T 09-03-2017 IPR001185 Large-conductance mechanosensitive channel GO:0005216|GO:0006810|GO:0016021 TK78_RS13375 d552b419aa8d64a89013dceaa6f6f5fb 152 SUPERFAMILY SSF81330 10 121 2.09E-23 T 09-03-2017 IPR001185 Large-conductance mechanosensitive channel GO:0005216|GO:0006810|GO:0016021 TK78_RS13375 d552b419aa8d64a89013dceaa6f6f5fb 152 TIGRFAM TIGR00220 mscL: large conductance mechanosensitive channel protein 2 108 1.5E-20 T 09-03-2017 IPR001185 Large-conductance mechanosensitive channel GO:0005216|GO:0006810|GO:0016021 TK78_RS31615 14359e732730edee37d2c2d438e7cb47 103 Pfam PF00699 Urease beta subunit 3 99 8.0E-40 T 09-03-2017 IPR002019 Urease, beta subunit KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 TK78_RS31615 14359e732730edee37d2c2d438e7cb47 103 Gene3D G3DSA:2.10.150.10 1 102 2.9E-45 T 09-03-2017 IPR002019 Urease, beta subunit KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 TK78_RS31615 14359e732730edee37d2c2d438e7cb47 103 TIGRFAM TIGR00192 urease_beta: urease, beta subunit 1 102 5.0E-37 T 09-03-2017 IPR002019 Urease, beta subunit KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 TK78_RS31615 14359e732730edee37d2c2d438e7cb47 103 SUPERFAMILY SSF51278 1 102 1.7E-43 T 09-03-2017 IPR002019 Urease, beta subunit KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 TK78_RS31615 14359e732730edee37d2c2d438e7cb47 103 Hamap MF_01954 Urease subunit beta [ureB]. 1 101 29.937 T 09-03-2017 IPR002019 Urease, beta subunit KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 TK78_RS14070 e4a111e9dad7708d541a633d738aa610 230 SMART SM00899 153 229 1.2E-6 T 09-03-2017 IPR007167 Ferrous iron transporter FeoA domain GO:0046914 TK78_RS14070 e4a111e9dad7708d541a633d738aa610 230 SUPERFAMILY SSF50037 130 229 7.55E-24 T 09-03-2017 IPR008988 Transcriptional repressor, C-terminal TK78_RS14070 e4a111e9dad7708d541a633d738aa610 230 Pfam PF01325 Iron dependent repressor, N-terminal DNA binding domain 4 62 1.1E-19 T 09-03-2017 IPR022687 DTXR-type HTH domain GO:0003677 TK78_RS14070 e4a111e9dad7708d541a633d738aa610 230 Gene3D G3DSA:2.30.30.90 134 229 8.5E-32 T 09-03-2017 TK78_RS14070 e4a111e9dad7708d541a633d738aa610 230 SMART SM00529 26 125 5.2E-48 T 09-03-2017 IPR022689 Iron dependent repressor GO:0003700|GO:0006355|GO:0046914 TK78_RS14070 e4a111e9dad7708d541a633d738aa610 230 Gene3D G3DSA:1.10.60.10 75 133 9.2E-30 T 09-03-2017 IPR001367 Iron dependent repressor, metal binding and dimerisation domain GO:0046914|GO:0046983 TK78_RS14070 e4a111e9dad7708d541a633d738aa610 230 Pfam PF04023 FeoA domain 155 228 3.6E-7 T 09-03-2017 IPR007167 Ferrous iron transporter FeoA domain GO:0046914 TK78_RS14070 e4a111e9dad7708d541a633d738aa610 230 SUPERFAMILY SSF47979 65 137 6.41E-26 T 09-03-2017 IPR001367 Iron dependent repressor, metal binding and dimerisation domain GO:0046914|GO:0046983 TK78_RS14070 e4a111e9dad7708d541a633d738aa610 230 Gene3D G3DSA:1.10.10.10 2 73 3.8E-28 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS14070 e4a111e9dad7708d541a633d738aa610 230 Pfam PF02742 Iron dependent repressor, metal binding and dimerisation domain 65 133 3.5E-29 T 09-03-2017 IPR001367 Iron dependent repressor, metal binding and dimerisation domain GO:0046914|GO:0046983 TK78_RS14070 e4a111e9dad7708d541a633d738aa610 230 SUPERFAMILY SSF46785 3 62 7.56E-13 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS01935 867a05769cb43530af3a930242478e13 71 Pfam PF09489 Probable cobalt transporter subunit (CbtB) 19 71 1.2E-13 T 09-03-2017 IPR012667 Cobalt transporter subunit CbtB, putative TK78_RS34470 73c4ee39ca83acfd624743ae1f356b91 512 SUPERFAMILY SSF53474 295 507 3.44E-25 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS34470 73c4ee39ca83acfd624743ae1f356b91 512 Gene3D G3DSA:3.40.50.1820 295 508 1.2E-22 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS34470 73c4ee39ca83acfd624743ae1f356b91 512 SUPERFAMILY SSF53474 3 257 2.92E-18 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS34470 73c4ee39ca83acfd624743ae1f356b91 512 Gene3D G3DSA:3.40.50.1820 4 259 5.2E-30 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS26870 7bbd0a7d60c7c8e1d292ff3eba91d0dd 395 Gene3D G3DSA:3.40.50.300 1 272 4.4E-27 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS26870 7bbd0a7d60c7c8e1d292ff3eba91d0dd 395 Pfam PF02374 Anion-transporting ATPase 1 293 8.2E-28 T 09-03-2017 IPR025723 Anion-transporting ATPase-like domain Reactome: R-HSA-381038 TK78_RS26870 7bbd0a7d60c7c8e1d292ff3eba91d0dd 395 SUPERFAMILY SSF52540 1 269 2.44E-24 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS02720 bcd35ac6a65149f69d378efb9bbdfc57 299 Gene3D G3DSA:3.40.50.10330 75 161 1.0E-5 T 09-03-2017 IPR017438 Inorganic polyphosphate/ATP-NAD kinase, domain 1 GO:0003951|GO:0008152 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 TK78_RS02720 bcd35ac6a65149f69d378efb9bbdfc57 299 SUPERFAMILY SSF111331 71 211 6.21E-16 T 09-03-2017 IPR016064 NAD kinase/diacylglycerol kinase-like domain TK78_RS02720 bcd35ac6a65149f69d378efb9bbdfc57 299 Gene3D G3DSA:2.60.200.30 162 210 4.1E-7 T 09-03-2017 IPR017437 ATP-NAD kinase, PpnK-type, all-beta GO:0003951|GO:0008152|GO:0019674 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 TK78_RS02720 bcd35ac6a65149f69d378efb9bbdfc57 299 Pfam PF01513 ATP-NAD kinase 39 208 9.9E-5 T 09-03-2017 IPR002504 NAD kinase GO:0003951|GO:0006741|GO:0008152 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 TK78_RS19710 be489b001297a75859125cb1f313d122 380 Pfam PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 131 301 3.6E-48 T 09-03-2017 IPR001135 NADH-quinone oxidoreductase, subunit D GO:0016651|GO:0048038|GO:0051287|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS19710 be489b001297a75859125cb1f313d122 380 Pfam PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 306 380 5.1E-21 T 09-03-2017 IPR001135 NADH-quinone oxidoreductase, subunit D GO:0016651|GO:0048038|GO:0051287|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS19710 be489b001297a75859125cb1f313d122 380 Gene3D G3DSA:1.10.645.10 14 368 1.3E-60 T 09-03-2017 IPR029014 NiFe hydrogenase-like Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS19710 be489b001297a75859125cb1f313d122 380 Hamap MF_01358 NAD(P)H-quinone oxidoreductase subunit H, chloroplastic [ndhH]. 1 380 40.545 T 09-03-2017 IPR022885 NAD(P)H-quinone oxidoreductase subunit D/H GO:0016651|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS19710 be489b001297a75859125cb1f313d122 380 ProSitePatterns PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature. 53 64 - T 09-03-2017 IPR014029 NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site GO:0016651|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS19710 be489b001297a75859125cb1f313d122 380 SUPERFAMILY SSF56762 26 379 8.11E-104 T 09-03-2017 IPR029014 NiFe hydrogenase-like Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS25965 2bcf387b5159d117050a4c2ee941c73e 358 SUPERFAMILY SSF51735 150 325 1.65E-40 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS25965 2bcf387b5159d117050a4c2ee941c73e 358 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 60 74 - T 09-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 TK78_RS25965 2bcf387b5159d117050a4c2ee941c73e 358 Gene3D G3DSA:3.90.180.10 1 182 3.1E-55 T 09-03-2017 IPR011032 GroES-like TK78_RS25965 2bcf387b5159d117050a4c2ee941c73e 358 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 27 145 3.8E-27 T 09-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 TK78_RS25965 2bcf387b5159d117050a4c2ee941c73e 358 Gene3D G3DSA:3.40.50.720 183 298 4.2E-36 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS25965 2bcf387b5159d117050a4c2ee941c73e 358 SMART SM00829 10 352 5.2E-6 T 09-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 TK78_RS25965 2bcf387b5159d117050a4c2ee941c73e 358 SUPERFAMILY SSF50129 314 356 5.27E-6 T 09-03-2017 IPR011032 GroES-like TK78_RS25965 2bcf387b5159d117050a4c2ee941c73e 358 SUPERFAMILY SSF50129 1 181 7.61E-49 T 09-03-2017 IPR011032 GroES-like TK78_RS25965 2bcf387b5159d117050a4c2ee941c73e 358 Pfam PF00107 Zinc-binding dehydrogenase 189 312 1.7E-25 T 09-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 TK78_RS16290 3544ebb27a24edf6bae72de4c0c76cac 254 Pfam PF00072 Response regulator receiver domain 25 133 2.7E-27 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS16290 3544ebb27a24edf6bae72de4c0c76cac 254 Gene3D G3DSA:3.40.50.2300 23 140 1.4E-38 T 09-03-2017 TK78_RS16290 3544ebb27a24edf6bae72de4c0c76cac 254 SUPERFAMILY SSF52172 19 141 8.54E-41 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS16290 3544ebb27a24edf6bae72de4c0c76cac 254 SMART SM00448 23 133 1.6E-40 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS16290 3544ebb27a24edf6bae72de4c0c76cac 254 Gene3D G3DSA:1.10.10.10 159 252 3.6E-27 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS16290 3544ebb27a24edf6bae72de4c0c76cac 254 Pfam PF00486 Transcriptional regulatory protein, C terminal 182 251 3.6E-19 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS16290 3544ebb27a24edf6bae72de4c0c76cac 254 SMART SM00862 180 251 3.5E-21 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS16290 3544ebb27a24edf6bae72de4c0c76cac 254 SUPERFAMILY SSF46894 157 252 1.08E-25 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS32510 17d11374c5c211a060373d5fad446907 193 Gene3D G3DSA:2.60.60.30 20 182 1.0E-45 T 09-03-2017 TK78_RS32510 17d11374c5c211a060373d5fad446907 193 Pfam PF02342 TerD domain 1 180 6.3E-45 T 09-03-2017 IPR003325 TerD domain GO:0006950 TK78_RS23900 c9d58358ab81871ba864e4fa2f360307 250 Pfam PF00440 Bacterial regulatory proteins, tetR family 53 98 2.1E-14 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS23900 c9d58358ab81871ba864e4fa2f360307 250 SUPERFAMILY SSF46689 38 118 1.3E-19 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS23900 c9d58358ab81871ba864e4fa2f360307 250 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 53 66 2.1E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS23900 c9d58358ab81871ba864e4fa2f360307 250 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 74 97 2.1E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS23900 c9d58358ab81871ba864e4fa2f360307 250 Gene3D G3DSA:1.10.357.10 36 230 6.4E-33 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS23900 c9d58358ab81871ba864e4fa2f360307 250 ProSitePatterns PS01081 TetR-type HTH domain signature. 65 95 - T 09-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site TK78_RS26420 e5ff7ad08a7d16f6692f530e123fbfa0 250 Pfam PF08241 Methyltransferase domain 47 135 8.8E-18 T 09-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 TK78_RS26420 e5ff7ad08a7d16f6692f530e123fbfa0 250 Gene3D G3DSA:3.40.50.150 6 152 2.8E-29 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS26420 e5ff7ad08a7d16f6692f530e123fbfa0 250 SUPERFAMILY SSF53335 1 163 1.52E-33 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS26775 5fe9f86f896edb744136fd8bcfc05c3b 133 Gene3D G3DSA:3.40.50.2300 3 128 7.9E-11 T 09-03-2017 TK78_RS26775 5fe9f86f896edb744136fd8bcfc05c3b 133 SMART SM00448 5 121 0.0095 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS26775 5fe9f86f896edb744136fd8bcfc05c3b 133 SUPERFAMILY SSF52172 4 129 1.01E-8 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS34305 c364d9296f32752e3ebefd03bdd985b1 269 Pfam PF03413 Peptidase propeptide and YPEB domain 207 258 3.1E-5 T 09-03-2017 IPR025711 PepSY domain TK78_RS33130 092d6289385ba15352c24ef66e253328 815 Gene3D G3DSA:2.80.10.50 679 813 7.2E-30 T 09-03-2017 TK78_RS33130 092d6289385ba15352c24ef66e253328 815 Pfam PF14200 Ricin-type beta-trefoil lectin domain-like 677 753 2.9E-18 T 09-03-2017 IPR000772 Ricin B, lectin domain TK78_RS33130 092d6289385ba15352c24ef66e253328 815 Pfam PF14200 Ricin-type beta-trefoil lectin domain-like 763 813 4.1E-9 T 09-03-2017 IPR000772 Ricin B, lectin domain TK78_RS33130 092d6289385ba15352c24ef66e253328 815 Pfam PF07944 Beta-L-arabinofuranosidase, GH127 110 549 9.4E-63 T 09-03-2017 IPR012878 Beta-L-arabinofuranosidase, GH127 KEGG: 00511+3.2.1.18|KEGG: 00600+3.2.1.18 TK78_RS33130 092d6289385ba15352c24ef66e253328 815 SUPERFAMILY SSF48208 94 376 2.3E-15 T 09-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 TK78_RS33130 092d6289385ba15352c24ef66e253328 815 SUPERFAMILY SSF50370 676 813 6.81E-41 T 09-03-2017 IPR000772 Ricin B, lectin domain TK78_RS00180 d6193d1244512995ee53fef233dceb0f 151 Gene3D G3DSA:3.40.50.1000 7 90 2.3E-11 T 09-03-2017 IPR023214 HAD-like domain TK78_RS00180 d6193d1244512995ee53fef233dceb0f 151 Pfam PF13242 HAD-hyrolase-like 23 80 8.5E-8 T 09-03-2017 TK78_RS00180 d6193d1244512995ee53fef233dceb0f 151 SUPERFAMILY SSF56784 24 92 1.25E-11 T 09-03-2017 IPR023214 HAD-like domain TK78_RS05910 a8d59746605c449541b61bc09788582f 365 SUPERFAMILY SSF51726 26 362 3.66E-105 T 09-03-2017 TK78_RS05910 a8d59746605c449541b61bc09788582f 365 ProSitePatterns PS00907 Uroporphyrinogen decarboxylase signature 2. 160 176 - T 09-03-2017 IPR000257 Uroporphyrinogen decarboxylase (URO-D) GO:0004853|GO:0006779 KEGG: 00860+4.1.1.37|MetaCyc: PWY-5531|MetaCyc: PWY-7159|Reactome: R-HSA-189451 TK78_RS05910 a8d59746605c449541b61bc09788582f 365 ProSitePatterns PS00906 Uroporphyrinogen decarboxylase signature 1. 43 52 - T 09-03-2017 IPR000257 Uroporphyrinogen decarboxylase (URO-D) GO:0004853|GO:0006779 KEGG: 00860+4.1.1.37|MetaCyc: PWY-5531|MetaCyc: PWY-7159|Reactome: R-HSA-189451 TK78_RS05910 a8d59746605c449541b61bc09788582f 365 Gene3D G3DSA:3.20.20.210 25 362 1.3E-144 T 09-03-2017 TK78_RS05910 a8d59746605c449541b61bc09788582f 365 TIGRFAM TIGR01464 hemE: uroporphyrinogen decarboxylase 30 361 3.9E-121 T 09-03-2017 IPR006361 Uroporphyrinogen decarboxylase HemE GO:0004853|GO:0006779 KEGG: 00860+4.1.1.37|MetaCyc: PWY-5531|MetaCyc: PWY-7159|Reactome: R-HSA-189451 TK78_RS05910 a8d59746605c449541b61bc09788582f 365 Hamap MF_00218 Uroporphyrinogen decarboxylase [hemE]. 27 363 47.172 T 09-03-2017 IPR006361 Uroporphyrinogen decarboxylase HemE GO:0004853|GO:0006779 KEGG: 00860+4.1.1.37|MetaCyc: PWY-5531|MetaCyc: PWY-7159|Reactome: R-HSA-189451 TK78_RS05910 a8d59746605c449541b61bc09788582f 365 Pfam PF01208 Uroporphyrinogen decarboxylase (URO-D) 25 361 9.4E-129 T 09-03-2017 IPR000257 Uroporphyrinogen decarboxylase (URO-D) GO:0004853|GO:0006779 KEGG: 00860+4.1.1.37|MetaCyc: PWY-5531|MetaCyc: PWY-7159|Reactome: R-HSA-189451 TK78_RS10470 0dadf1f89884c9e5783dfeb074a0e032 266 Pfam PF00459 Inositol monophosphatase family 10 264 1.9E-47 T 09-03-2017 IPR000760 Inositol monophosphatase GO:0046854 TK78_RS10470 0dadf1f89884c9e5783dfeb074a0e032 266 Gene3D G3DSA:3.30.540.10 3 158 4.3E-44 T 09-03-2017 TK78_RS10470 0dadf1f89884c9e5783dfeb074a0e032 266 Gene3D G3DSA:3.40.190.80 159 264 7.6E-22 T 09-03-2017 TK78_RS10470 0dadf1f89884c9e5783dfeb074a0e032 266 PRINTS PR00377 Inositol monophosphatase superfamily signature 214 238 5.0E-21 T 09-03-2017 IPR000760 Inositol monophosphatase GO:0046854 TK78_RS10470 0dadf1f89884c9e5783dfeb074a0e032 266 PRINTS PR00377 Inositol monophosphatase superfamily signature 40 60 5.0E-21 T 09-03-2017 IPR000760 Inositol monophosphatase GO:0046854 TK78_RS10470 0dadf1f89884c9e5783dfeb074a0e032 266 PRINTS PR00377 Inositol monophosphatase superfamily signature 62 78 5.0E-21 T 09-03-2017 IPR000760 Inositol monophosphatase GO:0046854 TK78_RS10470 0dadf1f89884c9e5783dfeb074a0e032 266 PRINTS PR00377 Inositol monophosphatase superfamily signature 81 97 5.0E-21 T 09-03-2017 IPR000760 Inositol monophosphatase GO:0046854 TK78_RS10470 0dadf1f89884c9e5783dfeb074a0e032 266 TIGRFAM TIGR02067 his_9_HisN: histidinol-phosphatase 8 262 1.9E-88 T 09-03-2017 IPR011809 Histidinol-phosphate phosphatase, putative, inositol monophosphatase GO:0004401 KEGG: 00340+3.1.3.15 TK78_RS10470 0dadf1f89884c9e5783dfeb074a0e032 266 ProSitePatterns PS00629 Inositol monophosphatase family signature 1. 81 94 - T 09-03-2017 IPR020583 Inositol monophosphatase, metal-binding site TK78_RS10470 0dadf1f89884c9e5783dfeb074a0e032 266 SUPERFAMILY SSF56655 3 264 3.93E-74 T 09-03-2017 TK78_RS10470 0dadf1f89884c9e5783dfeb074a0e032 266 ProSitePatterns PS00630 Inositol monophosphatase family signature 2. 217 231 - T 09-03-2017 IPR020550 Inositol monophosphatase, conserved site GO:0046854 TK78_RS12765 d9565b2418d17c677e9e3851ab39da29 291 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 96 286 1.1E-16 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS12765 d9565b2418d17c677e9e3851ab39da29 291 SUPERFAMILY SSF161098 50 277 1.83E-46 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS12765 d9565b2418d17c677e9e3851ab39da29 291 Gene3D G3DSA:1.10.3720.10 57 286 3.2E-47 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS15640 2b1a341678b2179996911d501ca2098a 268 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 40 256 2.8E-20 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS15640 2b1a341678b2179996911d501ca2098a 268 Gene3D G3DSA:3.40.50.1110 34 257 2.0E-61 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS15640 2b1a341678b2179996911d501ca2098a 268 SUPERFAMILY SSF52266 36 256 1.38E-57 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS19355 3626bf7c36177bb604572ac3736afe33 406 Gene3D G3DSA:3.40.50.720 170 240 1.6E-17 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS19355 3626bf7c36177bb604572ac3736afe33 406 Gene3D G3DSA:3.40.50.720 12 81 1.6E-17 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS19355 3626bf7c36177bb604572ac3736afe33 406 Pfam PF13450 NAD(P)-binding Rossmann-like domain 12 59 1.8E-8 T 09-03-2017 TK78_RS19355 3626bf7c36177bb604572ac3736afe33 406 SUPERFAMILY SSF51971 354 389 1.01E-22 T 09-03-2017 TK78_RS19355 3626bf7c36177bb604572ac3736afe33 406 SUPERFAMILY SSF51971 10 255 1.01E-22 T 09-03-2017 TK78_RS19355 3626bf7c36177bb604572ac3736afe33 406 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 9 31 9.6E-5 T 09-03-2017 TK78_RS19355 3626bf7c36177bb604572ac3736afe33 406 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 358 365 9.6E-5 T 09-03-2017 TK78_RS22190 03210f0255a2d06e6a685aa5afcc4099 282 SUPERFAMILY SSF53335 75 143 1.28E-10 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS22190 03210f0255a2d06e6a685aa5afcc4099 282 SUPERFAMILY SSF53335 188 254 1.28E-10 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS22190 03210f0255a2d06e6a685aa5afcc4099 282 Pfam PF05711 Macrocin-O-methyltransferase (TylF) 74 274 1.5E-42 T 09-03-2017 IPR008884 Macrocin-O-methyltransferase TK78_RS29910 f40f6b105b9a802027db519aa973e301 228 SUPERFAMILY SSF55729 20 178 4.5E-36 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS29910 f40f6b105b9a802027db519aa973e301 228 Gene3D G3DSA:3.40.630.30 21 209 2.7E-47 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS29910 f40f6b105b9a802027db519aa973e301 228 Pfam PF13302 Acetyltransferase (GNAT) domain 27 167 8.5E-27 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS32055 b36ebc8f58f3380a64dfb102a39a152f 362 Pfam PF00107 Zinc-binding dehydrogenase 198 291 8.8E-18 T 09-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 TK78_RS32055 b36ebc8f58f3380a64dfb102a39a152f 362 SUPERFAMILY SSF51735 160 327 3.47E-34 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS32055 b36ebc8f58f3380a64dfb102a39a152f 362 SUPERFAMILY SSF50129 2 194 1.46E-49 T 09-03-2017 IPR011032 GroES-like TK78_RS32055 b36ebc8f58f3380a64dfb102a39a152f 362 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 29 154 5.6E-18 T 09-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 TK78_RS32055 b36ebc8f58f3380a64dfb102a39a152f 362 Gene3D G3DSA:3.90.180.10 3 190 1.2E-48 T 09-03-2017 IPR011032 GroES-like TK78_RS32055 b36ebc8f58f3380a64dfb102a39a152f 362 Gene3D G3DSA:3.40.50.720 191 294 1.6E-29 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS15730 3df287647cc25ed05ad52b29c8d1aec7 460 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 254 291 - T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS15730 3df287647cc25ed05ad52b29c8d1aec7 460 SUPERFAMILY SSF53383 21 449 7.54E-117 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS15730 3df287647cc25ed05ad52b29c8d1aec7 460 Pfam PF00202 Aminotransferase class-III 40 448 3.9E-97 T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS15730 3df287647cc25ed05ad52b29c8d1aec7 460 Gene3D G3DSA:3.90.1150.10 326 450 3.2E-30 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS15730 3df287647cc25ed05ad52b29c8d1aec7 460 Gene3D G3DSA:3.40.640.10 74 325 6.6E-80 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS06055 d1fae94a33b16c9b9a653741bffa857e 293 SUPERFAMILY SSF46955 6 117 4.76E-22 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS06055 d1fae94a33b16c9b9a653741bffa857e 293 Gene3D G3DSA:1.10.1660.10 4 57 2.4E-20 T 09-03-2017 TK78_RS06055 d1fae94a33b16c9b9a653741bffa857e 293 Gene3D G3DSA:1.10.1660.10 58 130 7.1E-12 T 09-03-2017 TK78_RS06055 d1fae94a33b16c9b9a653741bffa857e 293 SMART SM00422 4 72 2.2E-23 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS06055 d1fae94a33b16c9b9a653741bffa857e 293 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 5 16 1.2E-10 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS06055 d1fae94a33b16c9b9a653741bffa857e 293 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 16 29 1.2E-10 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS06055 d1fae94a33b16c9b9a653741bffa857e 293 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 39 59 1.2E-10 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS06055 d1fae94a33b16c9b9a653741bffa857e 293 Pfam PF13411 MerR HTH family regulatory protein 5 68 3.7E-14 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS16515 9d5e30a31e5f9d10545d7867d30c828b 200 Pfam PF13399 LytR cell envelope-related transcriptional attenuator 84 173 1.9E-14 T 09-03-2017 IPR027381 Putative LytR/CpsA/Psr regulator, C-terminal domain TK78_RS23580 cbe6abb0896971f95b4b8fca364bb938 496 Pfam PF00069 Protein kinase domain 22 291 1.8E-34 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS23580 cbe6abb0896971f95b4b8fca364bb938 496 Pfam PF03995 Peptidase inhibitor family I36 370 440 5.9E-10 T 09-03-2017 TK78_RS23580 cbe6abb0896971f95b4b8fca364bb938 496 SUPERFAMILY SSF56112 12 291 9.85E-48 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS23580 cbe6abb0896971f95b4b8fca364bb938 496 Gene3D G3DSA:3.30.200.20 17 150 1.1E-15 T 09-03-2017 TK78_RS23580 cbe6abb0896971f95b4b8fca364bb938 496 Gene3D G3DSA:1.10.510.10 151 291 9.7E-34 T 09-03-2017 TK78_RS23580 cbe6abb0896971f95b4b8fca364bb938 496 SMART SM00220 20 299 8.5E-31 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS33215 38b9382300d7a5cc35ac176655ecf04f 353 Gene3D G3DSA:1.10.1660.10 1 93 6.5E-19 T 09-03-2017 TK78_RS33215 38b9382300d7a5cc35ac176655ecf04f 353 Pfam PF00376 MerR family regulatory protein 1 28 1.4E-7 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS33215 38b9382300d7a5cc35ac176655ecf04f 353 SUPERFAMILY SSF46955 1 92 1.65E-18 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS33215 38b9382300d7a5cc35ac176655ecf04f 353 Gene3D G3DSA:3.40.50.150 136 267 5.9E-12 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS33215 38b9382300d7a5cc35ac176655ecf04f 353 Pfam PF08241 Methyltransferase domain 144 222 6.4E-7 T 09-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 TK78_RS33215 38b9382300d7a5cc35ac176655ecf04f 353 SMART SM00422 1 59 2.3E-11 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS33215 38b9382300d7a5cc35ac176655ecf04f 353 SUPERFAMILY SSF53335 124 300 4.92E-13 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS12295 3fcae7e34a6508473173ada3001b0589 29 Pfam PF09604 F subunit of K+-transporting ATPase (Potass_KdpF) 6 29 3.8E-9 T 09-03-2017 IPR011726 K+ transporting P-type ATPase, F subunit GO:0005886|GO:0008556|GO:0043462 TK78_RS12295 3fcae7e34a6508473173ada3001b0589 29 TIGRFAM TIGR02115 potass_kdpF: K+-transporting ATPase, F subunit 6 29 3.2E-10 T 09-03-2017 IPR011726 K+ transporting P-type ATPase, F subunit GO:0005886|GO:0008556|GO:0043462 TK78_RS06885 639c831a88957431f3f3db297a6244cc 244 SUPERFAMILY SSF52540 22 243 5.07E-71 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06885 639c831a88957431f3f3db297a6244cc 244 SMART SM00382 51 239 2.7E-15 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS06885 639c831a88957431f3f3db297a6244cc 244 ProSitePatterns PS00211 ABC transporters family signature. 163 177 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS06885 639c831a88957431f3f3db297a6244cc 244 Pfam PF00005 ABC transporter 42 190 1.3E-33 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS06885 639c831a88957431f3f3db297a6244cc 244 Gene3D G3DSA:3.40.50.300 21 243 2.3E-71 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS11345 be7d164ecbf75b2ea5e3985941f52416 250 Gene3D G3DSA:3.30.420.40 2 104 1.7E-42 T 09-03-2017 TK78_RS11345 be7d164ecbf75b2ea5e3985941f52416 250 Gene3D G3DSA:3.30.420.40 105 243 8.1E-39 T 09-03-2017 TK78_RS11345 be7d164ecbf75b2ea5e3985941f52416 250 SUPERFAMILY SSF53067 1 244 4.87E-38 T 09-03-2017 TK78_RS11345 be7d164ecbf75b2ea5e3985941f52416 250 Pfam PF00480 ROK family 4 160 2.6E-19 T 09-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 TK78_RS23870 c0de012acc676fc03b146b4a87b50732 560 SUPERFAMILY SSF103473 268 440 2.09E-57 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS23870 c0de012acc676fc03b146b4a87b50732 560 SUPERFAMILY SSF103473 6 198 2.09E-57 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS23870 c0de012acc676fc03b146b4a87b50732 560 SUPERFAMILY SSF103473 497 525 2.09E-57 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS23870 c0de012acc676fc03b146b4a87b50732 560 Gene3D G3DSA:1.20.1250.20 9 200 1.7E-31 T 09-03-2017 TK78_RS23870 c0de012acc676fc03b146b4a87b50732 560 Pfam PF07690 Major Facilitator Superfamily 21 430 1.6E-43 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS23870 c0de012acc676fc03b146b4a87b50732 560 Gene3D G3DSA:1.20.1250.20 291 441 6.1E-17 T 09-03-2017 TK78_RS23870 c0de012acc676fc03b146b4a87b50732 560 Gene3D G3DSA:1.20.1250.20 498 526 6.1E-17 T 09-03-2017 TK78_RS04850 b57a39d08a6c4c51ac2fc81e272d5583 406 Pfam PF07730 Histidine kinase 202 267 4.6E-14 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS04850 b57a39d08a6c4c51ac2fc81e272d5583 406 SUPERFAMILY SSF55874 294 402 1.11E-9 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS19780 307f1633e13b450ecba1fda73775a46c 160 SUPERFAMILY SSF46785 3 114 7.94E-25 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS19780 307f1633e13b450ecba1fda73775a46c 160 Pfam PF03965 Penicillinase repressor 5 114 5.0E-24 T 09-03-2017 IPR005650 BlaI transcriptional regulatory family GO:0003677|GO:0045892 TK78_RS19780 307f1633e13b450ecba1fda73775a46c 160 Gene3D G3DSA:1.10.10.10 4 80 4.4E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS29310 efb8d193f2b91ea9105266b0901ea715 303 SUPERFAMILY SSF52980 38 196 6.97E-11 T 09-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 TK78_RS29310 efb8d193f2b91ea9105266b0901ea715 303 Pfam PF12705 PD-(D/E)XK nuclease superfamily 13 261 3.4E-39 T 09-03-2017 TK78_RS17955 bb25e0489f122caa1630ca3f3d0a609f 424 Pfam PF00999 Sodium/hydrogen exchanger family 15 372 3.2E-47 T 09-03-2017 IPR006153 Cation/H+ exchanger GO:0006812|GO:0015299|GO:0016021|GO:0055085 TK78_RS02165 3ffe752134886c36b247cb4e18190bf9 418 Pfam PF01547 Bacterial extracellular solute-binding protein 47 332 1.5E-41 T 09-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 TK78_RS02165 3ffe752134886c36b247cb4e18190bf9 418 Gene3D G3DSA:3.40.190.10 161 348 5.3E-40 T 09-03-2017 TK78_RS02165 3ffe752134886c36b247cb4e18190bf9 418 Gene3D G3DSA:3.40.190.10 32 160 1.2E-17 T 09-03-2017 TK78_RS02165 3ffe752134886c36b247cb4e18190bf9 418 SUPERFAMILY SSF53850 33 408 5.92E-66 T 09-03-2017 TK78_RS14085 808ebee0008db274c82bce2fe3ae67c1 235 Gene3D G3DSA:1.10.10.10 125 217 1.8E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS14085 808ebee0008db274c82bce2fe3ae67c1 235 Pfam PF00072 Response regulator receiver domain 3 112 3.3E-23 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS14085 808ebee0008db274c82bce2fe3ae67c1 235 Gene3D G3DSA:3.40.50.2300 1 120 1.2E-31 T 09-03-2017 TK78_RS14085 808ebee0008db274c82bce2fe3ae67c1 235 SMART SM00862 145 217 2.5E-21 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS14085 808ebee0008db274c82bce2fe3ae67c1 235 SUPERFAMILY SSF52172 1 178 9.81E-35 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS14085 808ebee0008db274c82bce2fe3ae67c1 235 Pfam PF00486 Transcriptional regulatory protein, C terminal 148 217 4.4E-20 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS14085 808ebee0008db274c82bce2fe3ae67c1 235 SMART SM00448 1 112 1.6E-33 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS32265 7ffff9200e8630a5f37790fb4e6af930 234 SUPERFAMILY SSF53335 25 196 1.51E-36 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS32265 7ffff9200e8630a5f37790fb4e6af930 234 ProSitePatterns PS00092 N-6 Adenine-specific DNA methylases signature. 116 122 - T 09-03-2017 IPR002052 DNA methylase, N-6 adenine-specific, conserved site GO:0003676|GO:0008168|GO:0032259 TK78_RS32265 7ffff9200e8630a5f37790fb4e6af930 234 Pfam PF05175 Methyltransferase small domain 34 122 5.1E-15 T 09-03-2017 IPR007848 Methyltransferase small domain GO:0008168 TK78_RS32265 7ffff9200e8630a5f37790fb4e6af930 234 TIGRFAM TIGR00537 hemK_rel_arch: putative methylase 27 201 7.1E-27 T 09-03-2017 IPR004557 Eukaryotic/archaeal PrmC-related GO:0008276 Reactome: R-HSA-156581|Reactome: R-HSA-72764 TK78_RS32265 7ffff9200e8630a5f37790fb4e6af930 234 Gene3D G3DSA:3.40.50.150 25 198 1.3E-38 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS34525 ea862801a83fa2e53e92d7ac2f57ece1 463 SUPERFAMILY SSF51989 52 462 1.96E-101 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS34525 ea862801a83fa2e53e92d7ac2f57ece1 463 Gene3D G3DSA:3.20.20.40 46 462 1.0E-117 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS34525 ea862801a83fa2e53e92d7ac2f57ece1 463 ProSitePatterns PS00655 Glycosyl hydrolases family 6 signature 1. 122 138 - T 09-03-2017 IPR001524 Glycoside hydrolase, family 6, conserved site GO:0004553|GO:0005975 TK78_RS34525 ea862801a83fa2e53e92d7ac2f57ece1 463 Pfam PF01341 Glycosyl hydrolases family 6 71 410 1.7E-91 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS34525 ea862801a83fa2e53e92d7ac2f57ece1 463 PRINTS PR00733 Glycosyl hydrolase family 6 signature 149 164 1.5E-36 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS34525 ea862801a83fa2e53e92d7ac2f57ece1 463 PRINTS PR00733 Glycosyl hydrolase family 6 signature 261 271 1.5E-36 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS34525 ea862801a83fa2e53e92d7ac2f57ece1 463 PRINTS PR00733 Glycosyl hydrolase family 6 signature 117 130 1.5E-36 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS34525 ea862801a83fa2e53e92d7ac2f57ece1 463 PRINTS PR00733 Glycosyl hydrolase family 6 signature 70 89 1.5E-36 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS34525 ea862801a83fa2e53e92d7ac2f57ece1 463 PRINTS PR00733 Glycosyl hydrolase family 6 signature 221 234 1.5E-36 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS34525 ea862801a83fa2e53e92d7ac2f57ece1 463 PRINTS PR00733 Glycosyl hydrolase family 6 signature 365 385 1.5E-36 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS34525 ea862801a83fa2e53e92d7ac2f57ece1 463 PRINTS PR00733 Glycosyl hydrolase family 6 signature 324 337 1.5E-36 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS34525 ea862801a83fa2e53e92d7ac2f57ece1 463 PRINTS PR00733 Glycosyl hydrolase family 6 signature 388 402 1.5E-36 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS34525 ea862801a83fa2e53e92d7ac2f57ece1 463 PIRSF PIRSF001100 1 462 1.4E-97 T 09-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 TK78_RS32670 0ff8cc78b12ca173b9b21f5357f9aa28 181 Pfam PF13673 Acetyltransferase (GNAT) domain 54 154 3.7E-10 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS32670 0ff8cc78b12ca173b9b21f5357f9aa28 181 SUPERFAMILY SSF55729 10 161 3.04E-25 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS32670 0ff8cc78b12ca173b9b21f5357f9aa28 181 Gene3D G3DSA:3.40.630.30 11 161 1.8E-26 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS09605 6607ccb241ac3f3e8eb2ff9855d61710 833 SUPERFAMILY SSF52540 110 278 1.51E-7 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09605 6607ccb241ac3f3e8eb2ff9855d61710 833 Gene3D G3DSA:3.40.50.300 109 232 4.7E-5 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS21040 3505920fa8c005f8a0264ffb528bfa61 153 Pfam PF04686 Streptomyces sporulation and cell division protein, SsgA 23 112 3.2E-22 T 09-03-2017 IPR006776 Sporulation-specific cell division protein SsgB GO:0051301 TK78_RS01125 4220e0af9ad79deb1dc7b567624aec76 1044 Gene3D G3DSA:2.60.120.260 633 718 6.5E-18 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS01125 4220e0af9ad79deb1dc7b567624aec76 1044 Pfam PF00754 F5/8 type C domain 639 717 5.5E-16 T 09-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain TK78_RS01125 4220e0af9ad79deb1dc7b567624aec76 1044 Pfam PF00754 F5/8 type C domain 943 1024 9.9E-7 T 09-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain TK78_RS01125 4220e0af9ad79deb1dc7b567624aec76 1044 SUPERFAMILY SSF49785 942 1043 1.42E-7 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS01125 4220e0af9ad79deb1dc7b567624aec76 1044 Gene3D G3DSA:2.60.120.260 924 1002 1.2E-7 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS01125 4220e0af9ad79deb1dc7b567624aec76 1044 SUPERFAMILY SSF49785 631 719 1.21E-15 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS16655 8615a95613fe5e2c1d76ebba1a7762a5 419 SUPERFAMILY SSF53448 11 232 2.17E-39 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS16655 8615a95613fe5e2c1d76ebba1a7762a5 419 Pfam PF00535 Glycosyl transferase family 2 23 190 5.2E-26 T 09-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 TK78_RS16655 8615a95613fe5e2c1d76ebba1a7762a5 419 Pfam PF04138 GtrA-like protein 288 405 6.0E-12 T 09-03-2017 IPR007267 GtrA-like protein GO:0000271|GO:0006810|GO:0016021 TK78_RS16655 8615a95613fe5e2c1d76ebba1a7762a5 419 Gene3D G3DSA:3.90.550.10 22 224 8.4E-24 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS09080 9738346ff656e02c8b078e6408bd5dde 87 Pfam PF00550 Phosphopantetheine attachment site 13 75 3.4E-11 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS09080 9738346ff656e02c8b078e6408bd5dde 87 SUPERFAMILY SSF47336 2 84 2.49E-14 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS09080 9738346ff656e02c8b078e6408bd5dde 87 Gene3D G3DSA:1.10.1200.10 4 81 2.4E-13 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS19750 491bfbfc4f9728e73272a286c3fa062d 335 SUPERFAMILY SSF52374 11 225 7.04E-80 T 09-03-2017 TK78_RS19750 491bfbfc4f9728e73272a286c3fa062d 335 Gene3D G3DSA:3.30.1300.10 270 332 7.8E-32 T 09-03-2017 TK78_RS19750 491bfbfc4f9728e73272a286c3fa062d 335 Gene3D G3DSA:3.30.1300.10 178 222 7.8E-32 T 09-03-2017 TK78_RS19750 491bfbfc4f9728e73272a286c3fa062d 335 Hamap MF_00158 Pantothenate synthetase [panC]. 4 329 37.744 T 09-03-2017 IPR003721 Pantoate-beta-alanine ligase GO:0004592|GO:0015940 KEGG: 00410+6.3.2.1|KEGG: 00770+6.3.2.1 TK78_RS19750 491bfbfc4f9728e73272a286c3fa062d 335 Pfam PF02569 Pantoate-beta-alanine ligase 18 327 5.7E-87 T 09-03-2017 IPR003721 Pantoate-beta-alanine ligase GO:0004592|GO:0015940 KEGG: 00410+6.3.2.1|KEGG: 00770+6.3.2.1 TK78_RS19750 491bfbfc4f9728e73272a286c3fa062d 335 SUPERFAMILY SSF52374 277 331 1.44E-5 T 09-03-2017 TK78_RS19750 491bfbfc4f9728e73272a286c3fa062d 335 TIGRFAM TIGR00018 panC: pantoate--beta-alanine ligase 23 219 8.2E-70 T 09-03-2017 IPR003721 Pantoate-beta-alanine ligase GO:0004592|GO:0015940 KEGG: 00410+6.3.2.1|KEGG: 00770+6.3.2.1 TK78_RS19750 491bfbfc4f9728e73272a286c3fa062d 335 Gene3D G3DSA:3.40.50.620 15 177 5.6E-67 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS31700 29971b38d2078e1fb87e2002f466f515 192 Gene3D G3DSA:1.10.260.40 11 74 3.5E-18 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS31700 29971b38d2078e1fb87e2002f466f515 192 Pfam PF13560 Helix-turn-helix domain 14 69 1.2E-12 T 09-03-2017 TK78_RS31700 29971b38d2078e1fb87e2002f466f515 192 Pfam PF07883 Cupin domain 120 187 7.6E-7 T 09-03-2017 IPR013096 Cupin 2, conserved barrel TK78_RS31700 29971b38d2078e1fb87e2002f466f515 192 SMART SM00530 18 73 1.6E-12 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS31700 29971b38d2078e1fb87e2002f466f515 192 Gene3D G3DSA:2.60.120.10 75 189 4.0E-17 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS31700 29971b38d2078e1fb87e2002f466f515 192 SUPERFAMILY SSF47413 13 81 3.66E-16 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS31700 29971b38d2078e1fb87e2002f466f515 192 SUPERFAMILY SSF51182 69 189 3.9E-20 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS23460 06d5b3723208479690466814892b661c 323 Gene3D G3DSA:3.20.20.70 17 307 1.7E-82 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS23460 06d5b3723208479690466814892b661c 323 SUPERFAMILY SSF51569 15 310 4.98E-68 T 09-03-2017 TK78_RS23460 06d5b3723208479690466814892b661c 323 Pfam PF00682 HMGL-like 18 293 1.7E-46 T 09-03-2017 IPR000891 Pyruvate carboxyltransferase GO:0003824 TK78_RS33050 aaac45c03f5dab6e63602422e0dad6e6 367 SMART SM00331 130 360 1.1E-27 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS33050 aaac45c03f5dab6e63602422e0dad6e6 367 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 156 360 6.0E-40 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS05925 26b0c92e897ed0b92b4626086c147c7f 424 SUPERFAMILY SSF47819 225 336 9.38E-27 T 09-03-2017 IPR010997 HRDC-like GO:0000166|GO:0003824|GO:0044237 TK78_RS05925 26b0c92e897ed0b92b4626086c147c7f 424 Pfam PF01612 3'-5' exonuclease 42 205 4.7E-34 T 09-03-2017 IPR002562 3'-5' exonuclease domain GO:0003676|GO:0006139|GO:0008408 TK78_RS05925 26b0c92e897ed0b92b4626086c147c7f 424 SUPERFAMILY SSF53098 25 242 2.38E-50 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS05925 26b0c92e897ed0b92b4626086c147c7f 424 Pfam PF00570 HRDC domain 247 313 5.6E-13 T 09-03-2017 IPR002121 HRDC domain GO:0003676|GO:0005622 TK78_RS05925 26b0c92e897ed0b92b4626086c147c7f 424 SMART SM00474 39 205 8.7E-39 T 09-03-2017 IPR002562 3'-5' exonuclease domain GO:0003676|GO:0006139|GO:0008408 TK78_RS05925 26b0c92e897ed0b92b4626086c147c7f 424 SMART SM00341 244 324 7.5E-17 T 09-03-2017 IPR002121 HRDC domain GO:0003676|GO:0005622 TK78_RS05925 26b0c92e897ed0b92b4626086c147c7f 424 Gene3D G3DSA:3.30.420.10 41 213 3.0E-7 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS26250 2fbd972121a9bbe0a44ad9eca9b27134 584 PIRSF PIRSF006630 1 584 2.3E-211 T 09-03-2017 IPR014445 Glutamine-dependent NAD(+) synthetase GO:0003952|GO:0005524|GO:0009435 KEGG: 00760+6.3.5.1|MetaCyc: PWY-5381|MetaCyc: PWY-5653|Reactome: R-HSA-196807 TK78_RS26250 2fbd972121a9bbe0a44ad9eca9b27134 584 Gene3D G3DSA:3.60.110.10 3 260 2.0E-55 T 09-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 TK78_RS26250 2fbd972121a9bbe0a44ad9eca9b27134 584 SUPERFAMILY SSF56317 3 260 1.11E-55 T 09-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 TK78_RS26250 2fbd972121a9bbe0a44ad9eca9b27134 584 Gene3D G3DSA:3.40.50.620 300 564 2.3E-71 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS26250 2fbd972121a9bbe0a44ad9eca9b27134 584 TIGRFAM TIGR00552 nadE: NAD+ synthetase 315 558 1.4E-53 T 09-03-2017 IPR003694 NAD(+) synthetase GO:0003952|GO:0005524|GO:0009435 KEGG: 00760+6.3.1.5|Reactome: R-HSA-196807 TK78_RS26250 2fbd972121a9bbe0a44ad9eca9b27134 584 Pfam PF02540 NAD synthase 309 556 2.2E-66 T 09-03-2017 IPR022310 NAD/GMP synthase TK78_RS26250 2fbd972121a9bbe0a44ad9eca9b27134 584 ProSitePatterns PS00920 Nitrilases / cyanide hydratase signature 1. 36 51 - T 09-03-2017 IPR000132 Nitrilase/cyanide hydratase, conserved site GO:0016810 TK78_RS26250 2fbd972121a9bbe0a44ad9eca9b27134 584 Pfam PF00795 Carbon-nitrogen hydrolase 5 260 1.8E-25 T 09-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 TK78_RS26250 2fbd972121a9bbe0a44ad9eca9b27134 584 SUPERFAMILY SSF52402 300 565 1.28E-72 T 09-03-2017 TK78_RS15725 9b525f289dfb559153bfb2cbf702499a 278 SUPERFAMILY SSF48008 85 214 3.66E-11 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS15725 9b525f289dfb559153bfb2cbf702499a 278 Pfam PF00392 Bacterial regulatory proteins, gntR family 13 74 2.6E-16 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS15725 9b525f289dfb559153bfb2cbf702499a 278 SMART SM00345 16 74 2.4E-11 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS15725 9b525f289dfb559153bfb2cbf702499a 278 SUPERFAMILY SSF46785 9 78 3.86E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS15725 9b525f289dfb559153bfb2cbf702499a 278 Gene3D G3DSA:1.10.10.10 7 75 3.6E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS15725 9b525f289dfb559153bfb2cbf702499a 278 Gene3D G3DSA:1.20.120.530 78 213 2.0E-12 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS15725 9b525f289dfb559153bfb2cbf702499a 278 SMART SM00895 84 211 0.003 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS15725 9b525f289dfb559153bfb2cbf702499a 278 Pfam PF07729 FCD domain 87 209 7.9E-10 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS15550 06977d7eebccce7213123e26b5f12ccb 232 SUPERFAMILY SSF56784 14 226 3.1E-29 T 09-03-2017 IPR023214 HAD-like domain TK78_RS15550 06977d7eebccce7213123e26b5f12ccb 232 Pfam PF13419 Haloacid dehalogenase-like hydrolase 16 196 4.3E-15 T 09-03-2017 IPR023214 HAD-like domain TK78_RS15550 06977d7eebccce7213123e26b5f12ccb 232 Gene3D G3DSA:3.40.50.1000 99 226 3.3E-28 T 09-03-2017 IPR023214 HAD-like domain TK78_RS15550 06977d7eebccce7213123e26b5f12ccb 232 Gene3D G3DSA:3.40.50.1000 11 27 3.3E-28 T 09-03-2017 IPR023214 HAD-like domain TK78_RS15550 06977d7eebccce7213123e26b5f12ccb 232 TIGRFAM TIGR01549 HAD-SF-IA-v1: HAD hydrolase, family IA, variant 1 112 191 1.0E-5 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS25065 c1e39eaff57f4b3b7395f79fc709fcd6 899 Gene3D G3DSA:3.50.30.10 796 895 8.7E-26 T 09-03-2017 IPR008279 PEP-utilising enzyme, mobile domain GO:0016310|GO:0016772 TK78_RS25065 c1e39eaff57f4b3b7395f79fc709fcd6 899 Pfam PF01326 Pyruvate phosphate dikinase, PEP/pyruvate binding domain 26 322 5.6E-90 T 09-03-2017 IPR002192 Pyruvate phosphate dikinase, PEP/pyruvate-binding GO:0005524|GO:0016301|GO:0016310 TK78_RS25065 c1e39eaff57f4b3b7395f79fc709fcd6 899 Gene3D G3DSA:3.30.1490.20 13 193 6.0E-60 T 09-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 TK78_RS25065 c1e39eaff57f4b3b7395f79fc709fcd6 899 Pfam PF00391 PEP-utilising enzyme, mobile domain 822 893 7.9E-20 T 09-03-2017 IPR008279 PEP-utilising enzyme, mobile domain GO:0016310|GO:0016772 TK78_RS25065 c1e39eaff57f4b3b7395f79fc709fcd6 899 SUPERFAMILY SSF56059 12 354 1.77E-94 T 09-03-2017 TK78_RS25065 c1e39eaff57f4b3b7395f79fc709fcd6 899 SUPERFAMILY SSF52009 793 896 1.29E-26 T 09-03-2017 IPR008279 PEP-utilising enzyme, mobile domain GO:0016310|GO:0016772 TK78_RS25065 c1e39eaff57f4b3b7395f79fc709fcd6 899 Gene3D G3DSA:3.30.470.20 195 331 3.9E-43 T 09-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 TK78_RS02660 114cdaf209a9d42f3999432723fac577 192 Pfam PF02469 Fasciclin domain 70 190 4.0E-33 T 09-03-2017 IPR000782 FAS1 domain TK78_RS02660 114cdaf209a9d42f3999432723fac577 192 Gene3D G3DSA:2.30.180.10 61 189 2.2E-35 T 09-03-2017 IPR000782 FAS1 domain TK78_RS02660 114cdaf209a9d42f3999432723fac577 192 SUPERFAMILY SSF82153 56 191 2.22E-36 T 09-03-2017 IPR000782 FAS1 domain TK78_RS02660 114cdaf209a9d42f3999432723fac577 192 SMART SM00554 94 191 3.3E-32 T 09-03-2017 IPR000782 FAS1 domain TK78_RS09860 09bbae3dc99ba69b3b4d1490793b8921 301 TIGRFAM TIGR02778 ligD_pol: DNA ligase D, polymerase domain 12 256 6.7E-79 T 09-03-2017 IPR014145 DNA ligase D, polymerase domain TK78_RS20395 1a92bec35791dd7d32e935eeebf1ca26 344 SUPERFAMILY SSF56601 7 337 7.17E-77 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS20395 1a92bec35791dd7d32e935eeebf1ca26 344 Gene3D G3DSA:3.40.710.10 8 305 6.0E-79 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS20395 1a92bec35791dd7d32e935eeebf1ca26 344 Pfam PF00144 Beta-lactamase 10 322 7.4E-60 T 09-03-2017 IPR001466 Beta-lactamase-related TK78_RS24370 6afe76e61c7c663d35063e9b161b4b50 396 Pfam PF00999 Sodium/hydrogen exchanger family 6 363 7.1E-60 T 09-03-2017 IPR006153 Cation/H+ exchanger GO:0006812|GO:0015299|GO:0016021|GO:0055085 TK78_RS22370 b5a9afe96d1a866c34137226a9f08ebe 446 SUPERFAMILY SSF55205 7 440 6.54E-112 T 09-03-2017 IPR013792 RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta GO:0003824 TK78_RS22370 b5a9afe96d1a866c34137226a9f08ebe 446 Gene3D G3DSA:3.65.10.10 25 228 3.7E-52 T 09-03-2017 IPR001986 Enolpyruvate transferase domain GO:0016765 TK78_RS22370 b5a9afe96d1a866c34137226a9f08ebe 446 Gene3D G3DSA:3.65.10.10 229 439 8.3E-49 T 09-03-2017 IPR001986 Enolpyruvate transferase domain GO:0016765 TK78_RS22370 b5a9afe96d1a866c34137226a9f08ebe 446 TIGRFAM TIGR01072 murA: UDP-N-acetylglucosamine 1-carboxyvinyltransferase 7 439 1.9E-131 T 09-03-2017 IPR005750 UDP-N-acetylglucosamine 1-carboxyvinyltransferase GO:0008760|GO:0019277 KEGG: 00520+2.5.1.7|KEGG: 00550+2.5.1.7|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS22370 b5a9afe96d1a866c34137226a9f08ebe 446 Pfam PF00275 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) 11 431 8.2E-58 T 09-03-2017 IPR001986 Enolpyruvate transferase domain GO:0016765 TK78_RS02620 30241df656ef91c6b445731a3b15eb62 573 SUPERFAMILY SSF51905 20 348 1.43E-41 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS02620 30241df656ef91c6b445731a3b15eb62 573 Pfam PF01593 Flavin containing amine oxidoreductase 27 395 8.5E-13 T 09-03-2017 IPR002937 Amine oxidase GO:0016491|GO:0055114 TK78_RS02620 30241df656ef91c6b445731a3b15eb62 573 Gene3D G3DSA:3.50.50.60 231 351 8.3E-28 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS02620 30241df656ef91c6b445731a3b15eb62 573 Gene3D G3DSA:3.50.50.60 20 121 8.3E-28 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS17750 bfbd3cb481589687e9abe93eb638992d 228 SMART SM00895 94 218 1.2E-19 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS17750 bfbd3cb481589687e9abe93eb638992d 228 Gene3D G3DSA:1.10.10.10 9 84 6.8E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS17750 bfbd3cb481589687e9abe93eb638992d 228 SMART SM00345 26 84 2.2E-12 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS17750 bfbd3cb481589687e9abe93eb638992d 228 SUPERFAMILY SSF46785 18 88 4.67E-18 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS17750 bfbd3cb481589687e9abe93eb638992d 228 Pfam PF00392 Bacterial regulatory proteins, gntR family 23 84 2.3E-16 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS17750 bfbd3cb481589687e9abe93eb638992d 228 SUPERFAMILY SSF48008 90 224 1.31E-30 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS17750 bfbd3cb481589687e9abe93eb638992d 228 Gene3D G3DSA:1.20.120.530 88 224 8.2E-32 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS17750 bfbd3cb481589687e9abe93eb638992d 228 Pfam PF07729 FCD domain 94 216 1.5E-24 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS17750 bfbd3cb481589687e9abe93eb638992d 228 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 58 74 1.7E-7 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS17750 bfbd3cb481589687e9abe93eb638992d 228 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 44 58 1.7E-7 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS34065 26c179f2a5789f1e6f9ca5cd052f9ab3 388 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 195 376 2.1E-22 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS34065 26c179f2a5789f1e6f9ca5cd052f9ab3 388 Gene3D G3DSA:3.40.50.1110 192 382 4.7E-29 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS34065 26c179f2a5789f1e6f9ca5cd052f9ab3 388 SUPERFAMILY SSF52266 189 383 2.0E-40 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS15400 45daeaf43b30e93d23fdd106a905ac37 340 Gene3D G3DSA:3.40.50.1820 40 335 8.4E-72 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS15400 45daeaf43b30e93d23fdd106a905ac37 340 PRINTS PR00111 Alpha/beta hydrolase fold signature 137 150 3.5E-6 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS15400 45daeaf43b30e93d23fdd106a905ac37 340 PRINTS PR00111 Alpha/beta hydrolase fold signature 151 164 3.5E-6 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS15400 45daeaf43b30e93d23fdd106a905ac37 340 PRINTS PR00111 Alpha/beta hydrolase fold signature 93 108 3.5E-6 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS15400 45daeaf43b30e93d23fdd106a905ac37 340 Pfam PF12697 Alpha/beta hydrolase family 69 324 1.3E-21 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS15400 45daeaf43b30e93d23fdd106a905ac37 340 PRINTS PR00412 Epoxide hydrolase signature 93 108 3.3E-21 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS15400 45daeaf43b30e93d23fdd106a905ac37 340 PRINTS PR00412 Epoxide hydrolase signature 310 332 3.3E-21 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS15400 45daeaf43b30e93d23fdd106a905ac37 340 PRINTS PR00412 Epoxide hydrolase signature 73 91 3.3E-21 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS15400 45daeaf43b30e93d23fdd106a905ac37 340 PRINTS PR00412 Epoxide hydrolase signature 151 164 3.3E-21 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS15400 45daeaf43b30e93d23fdd106a905ac37 340 PRINTS PR00412 Epoxide hydrolase signature 137 150 3.3E-21 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS15400 45daeaf43b30e93d23fdd106a905ac37 340 PRINTS PR00412 Epoxide hydrolase signature 276 292 3.3E-21 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS15400 45daeaf43b30e93d23fdd106a905ac37 340 SUPERFAMILY SSF53474 45 335 1.36E-65 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS33740 5a032685f719393fc40aa934214c6b46 319 Pfam PF11258 Protein of unknown function (DUF3048) 50 313 3.6E-53 T 09-03-2017 IPR021416 Protein of unknown function DUF3048 TK78_RS33740 5a032685f719393fc40aa934214c6b46 319 Gene3D G3DSA:3.50.90.10 43 317 8.3E-68 T 09-03-2017 IPR023158 YerB-like domain TK78_RS33740 5a032685f719393fc40aa934214c6b46 319 SUPERFAMILY SSF159774 50 318 5.75E-71 T 09-03-2017 IPR023158 YerB-like domain TK78_RS21900 8560dc1cc3abaff1b01b0ebdd8c9a602 407 Pfam PF03816 Cell envelope-related transcriptional attenuator domain 164 318 1.7E-42 T 09-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain TK78_RS21900 8560dc1cc3abaff1b01b0ebdd8c9a602 407 TIGRFAM TIGR00350 lytR_cpsA_psr: cell envelope-related function transcriptional attenuator common domain 164 318 2.3E-38 T 09-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain TK78_RS00680 d7b66d4c75ed3b65b466297ff2e83ff4 289 PIRSF PIRSF001359 1 286 1.1E-68 T 09-03-2017 IPR000771 Ketose-bisphosphate aldolase, class-II GO:0005975|GO:0008270|GO:0016832 TK78_RS00680 d7b66d4c75ed3b65b466297ff2e83ff4 289 Pfam PF01116 Fructose-bisphosphate aldolase class-II 7 282 3.3E-81 T 09-03-2017 IPR000771 Ketose-bisphosphate aldolase, class-II GO:0005975|GO:0008270|GO:0016832 TK78_RS00680 d7b66d4c75ed3b65b466297ff2e83ff4 289 SUPERFAMILY SSF51569 3 281 1.39E-79 T 09-03-2017 TK78_RS00680 d7b66d4c75ed3b65b466297ff2e83ff4 289 Gene3D G3DSA:3.20.20.70 1 284 4.7E-87 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS00680 d7b66d4c75ed3b65b466297ff2e83ff4 289 TIGRFAM TIGR00167 cbbA: ketose-bisphosphate aldolase 4 280 1.3E-67 T 09-03-2017 IPR000771 Ketose-bisphosphate aldolase, class-II GO:0005975|GO:0008270|GO:0016832 TK78_RS18545 0abc4be4a34964595a50d0774a872002 475 Gene3D G3DSA:3.40.50.300 251 375 6.3E-13 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18545 0abc4be4a34964595a50d0774a872002 475 Gene3D G3DSA:3.40.50.300 73 159 6.3E-13 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18545 0abc4be4a34964595a50d0774a872002 475 SUPERFAMILY SSF52540 40 424 2.66E-33 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18545 0abc4be4a34964595a50d0774a872002 475 Pfam PF12846 AAA-like domain 69 350 1.8E-14 T 09-03-2017 TK78_RS25895 715432d603653d08e2111bee642152ad 243 Gene3D G3DSA:3.40.50.150 8 236 3.0E-50 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS25895 715432d603653d08e2111bee642152ad 243 Pfam PF08241 Methyltransferase domain 18 121 1.9E-23 T 09-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 TK78_RS25895 715432d603653d08e2111bee642152ad 243 SUPERFAMILY SSF53335 9 236 3.84E-43 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS31445 64545589554063c5219d2e840b38dc0e 475 Pfam PF00583 Acetyltransferase (GNAT) family 371 438 2.5E-8 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS31445 64545589554063c5219d2e840b38dc0e 475 Gene3D G3DSA:3.40.630.30 307 437 9.5E-19 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS31445 64545589554063c5219d2e840b38dc0e 475 SUPERFAMILY SSF55729 297 438 5.15E-22 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS10965 3793e8c20fb9f04141df14cb9cb33931 307 SUPERFAMILY SSF161098 90 293 2.22E-19 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS10965 3793e8c20fb9f04141df14cb9cb33931 307 Gene3D G3DSA:1.10.3720.10 89 301 4.2E-19 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS10965 3793e8c20fb9f04141df14cb9cb33931 307 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 112 306 9.1E-36 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS04455 b827eea100b78ba0f36eb67dd76c0a42 291 Gene3D G3DSA:1.10.3720.10 14 278 1.0E-54 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS04455 b827eea100b78ba0f36eb67dd76c0a42 291 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 106 281 2.4E-14 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS04455 b827eea100b78ba0f36eb67dd76c0a42 291 SUPERFAMILY SSF161098 16 291 1.96E-61 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS30350 0239098a4406623cd49e78c7c0bbc0de 403 Gene3D G3DSA:3.40.50.1950 3 176 8.5E-61 T 09-03-2017 IPR003382 Flavoprotein GO:0003824 Reactome: R-HSA-196783 TK78_RS30350 0239098a4406623cd49e78c7c0bbc0de 403 SUPERFAMILY SSF102645 183 399 7.85E-68 T 09-03-2017 IPR007085 DNA/pantothenate metabolism flavoprotein, C-terminal KEGG: 00770+6.3.2.5|Reactome: R-HSA-196783 TK78_RS30350 0239098a4406623cd49e78c7c0bbc0de 403 Gene3D G3DSA:3.40.50.10300 183 400 8.8E-81 T 09-03-2017 IPR007085 DNA/pantothenate metabolism flavoprotein, C-terminal KEGG: 00770+6.3.2.5|Reactome: R-HSA-196783 TK78_RS30350 0239098a4406623cd49e78c7c0bbc0de 403 TIGRFAM TIGR00521 coaBC_dfp: phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase 3 395 1.7E-121 T 09-03-2017 IPR005252 Coenzyme A biosynthesis bifunctional protein CoaBC GO:0004632|GO:0004633|GO:0010181|GO:0015937|GO:0015941 KEGG: 00770+4.1.1.36+6.3.2.5 TK78_RS30350 0239098a4406623cd49e78c7c0bbc0de 403 Pfam PF02441 Flavoprotein 5 130 4.2E-32 T 09-03-2017 IPR003382 Flavoprotein GO:0003824 Reactome: R-HSA-196783 TK78_RS30350 0239098a4406623cd49e78c7c0bbc0de 403 SUPERFAMILY SSF52507 2 176 3.14E-58 T 09-03-2017 IPR003382 Flavoprotein GO:0003824 Reactome: R-HSA-196783 TK78_RS30350 0239098a4406623cd49e78c7c0bbc0de 403 Pfam PF04127 DNA / pantothenate metabolism flavoprotein 185 369 1.1E-70 T 09-03-2017 IPR007085 DNA/pantothenate metabolism flavoprotein, C-terminal KEGG: 00770+6.3.2.5|Reactome: R-HSA-196783 TK78_RS34720 35e86e5526348ad1ba385a1bf9f16c4a 438 Pfam PF05977 Transmembrane secretion effector 11 410 9.6E-31 T 09-03-2017 IPR010290 Transmembrane secretion effector TK78_RS34720 35e86e5526348ad1ba385a1bf9f16c4a 438 Gene3D G3DSA:1.20.1250.20 225 407 1.1E-9 T 09-03-2017 TK78_RS34720 35e86e5526348ad1ba385a1bf9f16c4a 438 Gene3D G3DSA:1.20.1250.20 17 202 8.2E-14 T 09-03-2017 TK78_RS34720 35e86e5526348ad1ba385a1bf9f16c4a 438 SUPERFAMILY SSF103473 14 407 3.01E-36 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS17130 2e49c808e89fe1daf2c5bece56cefa1e 70 ProDom PD267558 MEMBRANE TRANSMEMBRANE SPANNING SCO3924 1 70 5.0E-18 T 09-03-2017 IPR020246 Uncharacterised protein family SCO3924 TK78_RS10145 0a0d403129e78f4f667e0f80fa148daa 393 Pfam PF06889 Protein of unknown function (DUF1266) 196 392 5.1E-33 T 09-03-2017 IPR009677 Protein of unknown function DUF1266 TK78_RS06050 21f61077a2a37441af05927b069f7f25 150 Gene3D G3DSA:3.40.630.30 25 141 7.7E-23 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS06050 21f61077a2a37441af05927b069f7f25 150 SUPERFAMILY SSF55729 23 137 6.34E-19 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS06050 21f61077a2a37441af05927b069f7f25 150 Pfam PF13302 Acetyltransferase (GNAT) domain 26 128 4.2E-14 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS28530 6165be8ac7aed2689290eef861bc1fb5 260 Pfam PF07070 SpoOM protein 3 216 2.3E-79 T 09-03-2017 IPR009776 Sporulation stage 0, protein M TK78_RS28135 a9f56acb1f23765b865943b8d8b792a8 507 Pfam PF00171 Aldehyde dehydrogenase family 8 414 9.2E-43 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS28135 a9f56acb1f23765b865943b8d8b792a8 507 Gene3D G3DSA:3.40.605.10 8 247 8.1E-41 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS28135 a9f56acb1f23765b865943b8d8b792a8 507 Gene3D G3DSA:3.40.309.10 248 440 7.9E-50 T 09-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 TK78_RS28135 a9f56acb1f23765b865943b8d8b792a8 507 SUPERFAMILY SSF53720 8 501 1.57E-84 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS19950 9f3c7b231f66715fb30a7ff09004f983 409 SUPERFAMILY SSF103473 11 395 5.1E-30 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS19950 9f3c7b231f66715fb30a7ff09004f983 409 Pfam PF07690 Major Facilitator Superfamily 222 396 5.0E-12 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS19950 9f3c7b231f66715fb30a7ff09004f983 409 Gene3D G3DSA:1.20.1250.20 214 395 5.5E-18 T 09-03-2017 TK78_RS19950 9f3c7b231f66715fb30a7ff09004f983 409 Gene3D G3DSA:1.20.1250.20 13 175 1.0E-5 T 09-03-2017 TK78_RS21090 c30694aca3180960bee359b4f7895602 304 SUPERFAMILY SSF56112 38 286 1.05E-29 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS21090 c30694aca3180960bee359b4f7895602 304 Gene3D G3DSA:3.90.1200.10 129 228 7.8E-5 T 09-03-2017 TK78_RS21090 c30694aca3180960bee359b4f7895602 304 Pfam PF04655 Aminoglycoside/hydroxyurea antibiotic resistance kinase 39 286 2.5E-77 T 09-03-2017 IPR006748 Aminoglycoside/hydroxyurea antibiotic resistance kinase GO:0006468|GO:0016773|GO:0019748 TK78_RS03215 c46f0a4d11933e87ccc739bea34d99ec 151 Pfam PF13581 Histidine kinase-like ATPase domain 26 120 6.0E-11 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS03215 c46f0a4d11933e87ccc739bea34d99ec 151 Gene3D G3DSA:3.30.565.10 25 148 9.1E-10 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS03215 c46f0a4d11933e87ccc739bea34d99ec 151 SUPERFAMILY SSF55874 50 147 1.7E-12 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS00855 80dc9defbefbff610597c8a06d042dd8 298 SUPERFAMILY SSF46785 2 86 1.5E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS00855 80dc9defbefbff610597c8a06d042dd8 298 SUPERFAMILY SSF53850 99 296 6.11E-34 T 09-03-2017 TK78_RS00855 80dc9defbefbff610597c8a06d042dd8 298 Gene3D G3DSA:3.40.190.10 89 178 8.3E-21 T 09-03-2017 TK78_RS00855 80dc9defbefbff610597c8a06d042dd8 298 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 4 63 1.7E-22 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS00855 80dc9defbefbff610597c8a06d042dd8 298 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 40 51 2.6E-9 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS00855 80dc9defbefbff610597c8a06d042dd8 298 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 30 40 2.6E-9 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS00855 80dc9defbefbff610597c8a06d042dd8 298 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 19 30 2.6E-9 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS00855 80dc9defbefbff610597c8a06d042dd8 298 Pfam PF03466 LysR substrate binding domain 89 295 6.9E-40 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS00855 80dc9defbefbff610597c8a06d042dd8 298 Gene3D G3DSA:3.40.190.10 179 263 2.0E-22 T 09-03-2017 TK78_RS00855 80dc9defbefbff610597c8a06d042dd8 298 Gene3D G3DSA:1.10.10.10 3 81 1.3E-28 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS01785 ab3d691491d7b015b697380d05ae1015 715 Gene3D G3DSA:1.10.3470.10 37 372 6.1E-75 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS01785 ab3d691491d7b015b697380d05ae1015 715 Gene3D G3DSA:1.10.3470.10 389 714 1.4E-91 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS01785 ab3d691491d7b015b697380d05ae1015 715 SUPERFAMILY SSF81345 386 710 9.81E-75 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS01785 ab3d691491d7b015b697380d05ae1015 715 Pfam PF01032 FecCD transport family 404 710 2.5E-84 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS01785 ab3d691491d7b015b697380d05ae1015 715 Pfam PF01032 FecCD transport family 51 370 1.1E-64 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS01785 ab3d691491d7b015b697380d05ae1015 715 SUPERFAMILY SSF81345 36 370 1.31E-57 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS04190 692c3cef7643b13c60268e501b41ee79 528 Gene3D G3DSA:3.40.50.1820 358 477 3.4E-63 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04190 692c3cef7643b13c60268e501b41ee79 528 Gene3D G3DSA:3.40.50.1820 53 137 3.4E-63 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04190 692c3cef7643b13c60268e501b41ee79 528 Gene3D G3DSA:3.40.50.1820 180 304 3.4E-63 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04190 692c3cef7643b13c60268e501b41ee79 528 SUPERFAMILY SSF53474 313 340 1.51E-26 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04190 692c3cef7643b13c60268e501b41ee79 528 SUPERFAMILY SSF53474 376 477 1.51E-26 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04190 692c3cef7643b13c60268e501b41ee79 528 SUPERFAMILY SSF53474 182 236 1.51E-26 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04190 692c3cef7643b13c60268e501b41ee79 528 SUPERFAMILY SSF53474 87 138 1.51E-26 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04190 692c3cef7643b13c60268e501b41ee79 528 Pfam PF00561 alpha/beta hydrolase fold 87 457 7.4E-39 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS33480 cc8afb31507e80528af1d225906b5d0d 216 SUPERFAMILY SSF63817 67 212 7.06E-17 T 09-03-2017 IPR023365 Sortase domain TK78_RS33480 cc8afb31507e80528af1d225906b5d0d 216 Pfam PF04203 Sortase family 73 211 3.7E-16 T 09-03-2017 IPR005754 Sortase family TK78_RS33480 cc8afb31507e80528af1d225906b5d0d 216 Gene3D G3DSA:2.40.260.10 73 201 3.0E-7 T 09-03-2017 IPR023365 Sortase domain TK78_RS34445 1f153a79f8233ad832250c5c4b0c2ecf 745 SUPERFAMILY SSF52540 176 255 3.73E-48 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS34445 1f153a79f8233ad832250c5c4b0c2ecf 745 SUPERFAMILY SSF52540 395 454 3.73E-48 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS34445 1f153a79f8233ad832250c5c4b0c2ecf 745 SUPERFAMILY SSF52540 520 737 3.73E-48 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS34445 1f153a79f8233ad832250c5c4b0c2ecf 745 Gene3D G3DSA:3.40.50.300 499 601 1.1E-31 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS34445 1f153a79f8233ad832250c5c4b0c2ecf 745 Gene3D G3DSA:3.40.50.300 177 285 1.1E-31 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS34445 1f153a79f8233ad832250c5c4b0c2ecf 745 Gene3D G3DSA:3.40.50.300 602 739 7.2E-19 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS34445 1f153a79f8233ad832250c5c4b0c2ecf 745 Pfam PF13245 Part of AAA domain 191 255 8.4E-16 T 09-03-2017 TK78_RS02330 ba71f7bae905a2226d4b5a5dd7eaad8d 290 Pfam PF14158 YndJ-like protein 7 256 2.5E-86 T 09-03-2017 IPR025450 YndJ-like protein TK78_RS12390 1c49c4f33c70c0e221ab391ef2bbf829 517 SUPERFAMILY SSF53850 32 514 9.31E-97 T 09-03-2017 TK78_RS12390 1c49c4f33c70c0e221ab391ef2bbf829 517 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 78 436 2.0E-65 T 09-03-2017 IPR000914 Solute-binding protein family 5 domain TK78_RS12390 1c49c4f33c70c0e221ab391ef2bbf829 517 Gene3D G3DSA:3.90.76.10 45 193 1.0E-26 T 09-03-2017 TK78_RS12390 1c49c4f33c70c0e221ab391ef2bbf829 517 Gene3D G3DSA:3.10.105.10 294 486 2.6E-48 T 09-03-2017 TK78_RS12390 1c49c4f33c70c0e221ab391ef2bbf829 517 PIRSF PIRSF002741 2 516 6.7E-68 T 09-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 TK78_RS12390 1c49c4f33c70c0e221ab391ef2bbf829 517 Gene3D G3DSA:3.40.190.10 194 293 1.1E-17 T 09-03-2017 TK78_RS16375 687a093c2b3de76ef8e290739c27507f 511 PIRSF PIRSF006060 2 476 8.5E-45 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS16375 687a093c2b3de76ef8e290739c27507f 511 Pfam PF13520 Amino acid permease 24 434 2.9E-27 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS31755 3682d549da13dd82fa324f098fe82b20 523 SUPERFAMILY SSF53335 242 494 1.66E-27 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS31755 3682d549da13dd82fa324f098fe82b20 523 Gene3D G3DSA:1.20.1250.20 50 214 7.2E-7 T 09-03-2017 TK78_RS31755 3682d549da13dd82fa324f098fe82b20 523 Gene3D G3DSA:3.40.50.150 242 511 1.6E-67 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS31755 3682d549da13dd82fa324f098fe82b20 523 SUPERFAMILY SSF103473 33 220 5.62E-9 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS23425 a1d9fb6fb85ba5a7f841a19bc5b46cfd 153 SUPERFAMILY SSF46785 36 146 2.45E-32 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS23425 a1d9fb6fb85ba5a7f841a19bc5b46cfd 153 Pfam PF01638 HxlR-like helix-turn-helix 47 134 4.7E-28 T 09-03-2017 IPR002577 Helix-turn-helix, HxlR type TK78_RS23425 a1d9fb6fb85ba5a7f841a19bc5b46cfd 153 Gene3D G3DSA:1.10.10.10 35 145 1.1E-45 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS26880 5b574cea0553a60a0d698bd70aedc2b7 313 Gene3D G3DSA:3.30.420.40 135 285 1.0E-51 T 09-03-2017 TK78_RS26880 5b574cea0553a60a0d698bd70aedc2b7 313 ProSitePatterns PS01125 ROK family signature. 130 157 - T 09-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 TK78_RS26880 5b574cea0553a60a0d698bd70aedc2b7 313 SUPERFAMILY SSF53067 2 312 3.06E-69 T 09-03-2017 TK78_RS26880 5b574cea0553a60a0d698bd70aedc2b7 313 TIGRFAM TIGR00744 ROK_glcA_fam: ROK family protein (putative glucokinase) 5 311 2.1E-133 T 09-03-2017 IPR004654 Glucokinase ROK GO:0004340|GO:0005737|GO:0006096|GO:0051156 KEGG: 00010+2.7.1.2|KEGG: 00052+2.7.1.2|KEGG: 00500+2.7.1.2|KEGG: 00520+2.7.1.2|KEGG: 00521+2.7.1.2|KEGG: 00524+2.7.1.2|MetaCyc: PWY-2722|MetaCyc: PWY-2723|MetaCyc: PWY-5514|MetaCyc: PWY-5661|MetaCyc: PWY-621|MetaCyc: PWY-7238|MetaCyc: PWY-7385 TK78_RS26880 5b574cea0553a60a0d698bd70aedc2b7 313 Pfam PF00480 ROK family 4 312 1.5E-101 T 09-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 TK78_RS26880 5b574cea0553a60a0d698bd70aedc2b7 313 Gene3D G3DSA:3.30.420.40 1 134 3.5E-46 T 09-03-2017 TK78_RS28045 d6a45590e02bccdab9ba93e0f92841b3 332 Gene3D G3DSA:2.160.10.10 165 319 4.7E-34 T 09-03-2017 TK78_RS28045 d6a45590e02bccdab9ba93e0f92841b3 332 Pfam PF14789 Tetrahydrodipicolinate N-succinyltransferase middle 124 164 6.8E-18 T 09-03-2017 IPR032784 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, middle domain KEGG: 00300+2.3.1.117 TK78_RS28045 d6a45590e02bccdab9ba93e0f92841b3 332 Hamap MF_02122 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase [dapD]. 12 329 43.65 T 09-03-2017 IPR026586 Type 2 tetrahydrodipicolinate N-succinyltransferase family GO:0008666 KEGG: 00300+2.3.1.117 TK78_RS28045 d6a45590e02bccdab9ba93e0f92841b3 332 Pfam PF14602 Hexapeptide repeat of succinyl-transferase 246 278 5.2E-14 T 09-03-2017 IPR001451 Hexapeptide repeat TK78_RS28045 d6a45590e02bccdab9ba93e0f92841b3 332 TIGRFAM TIGR03535 DapD_actino: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase 14 331 1.8E-152 T 09-03-2017 IPR019875 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, actinobacteria KEGG: 00300+2.3.1.117 TK78_RS28045 d6a45590e02bccdab9ba93e0f92841b3 332 SUPERFAMILY SSF51161 85 312 9.56E-40 T 09-03-2017 IPR011004 Trimeric LpxA-like TK78_RS28045 d6a45590e02bccdab9ba93e0f92841b3 332 Gene3D G3DSA:3.30.60.70 124 164 9.7E-15 T 09-03-2017 IPR032784 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, middle domain KEGG: 00300+2.3.1.117 TK78_RS03970 a639969f8a93a241af951bacd8133126 282 PIRSF PIRSF015626 1 278 1.1E-91 T 09-03-2017 IPR003786 Protein FdhD GO:0016783 TK78_RS03970 a639969f8a93a241af951bacd8133126 282 Gene3D G3DSA:3.40.140.10 138 277 8.2E-56 T 09-03-2017 TK78_RS03970 a639969f8a93a241af951bacd8133126 282 Hamap MF_00187 Sulfurtransferase FdhD [fdhD]. 2 274 34.338 T 09-03-2017 IPR003786 Protein FdhD GO:0016783 TK78_RS03970 a639969f8a93a241af951bacd8133126 282 Pfam PF02634 FdhD/NarQ family 26 273 5.8E-82 T 09-03-2017 IPR003786 Protein FdhD GO:0016783 TK78_RS03970 a639969f8a93a241af951bacd8133126 282 Gene3D G3DSA:3.10.20.10 28 120 4.2E-28 T 09-03-2017 TK78_RS03970 a639969f8a93a241af951bacd8133126 282 TIGRFAM TIGR00129 fdhD_narQ: formate dehydrogenase family accessory protein FdhD 22 273 4.1E-50 T 09-03-2017 IPR003786 Protein FdhD GO:0016783 TK78_RS03970 a639969f8a93a241af951bacd8133126 282 SUPERFAMILY SSF53927 5 273 2.26E-79 T 09-03-2017 IPR016193 Cytidine deaminase-like GO:0003824 TK78_RS06020 b79f832cbc955a46005dfa97293e86de 306 Gene3D G3DSA:1.10.3720.10 57 302 8.5E-56 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS06020 b79f832cbc955a46005dfa97293e86de 306 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 106 301 4.3E-16 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS06020 b79f832cbc955a46005dfa97293e86de 306 SUPERFAMILY SSF161098 51 293 7.19E-51 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS10160 2da7677073e632e22c7ab8757399421c 119 SUPERFAMILY SSF56399 5 105 3.45E-22 T 09-03-2017 TK78_RS10160 2da7677073e632e22c7ab8757399421c 119 Pfam PF06108 Protein of unknown function (DUF952) 10 102 1.6E-25 T 09-03-2017 IPR009297 Protein of unknown function DUF952 TK78_RS03080 46b8443c38880495ebb6d626b4047411 319 Gene3D G3DSA:3.80.10.10 32 298 9.9E-59 T 09-03-2017 IPR032675 Leucine-rich repeat domain, L domain-like TK78_RS03080 46b8443c38880495ebb6d626b4047411 319 SUPERFAMILY SSF52047 111 282 2.75E-10 T 09-03-2017 TK78_RS25090 b5c459e9d6418694027ef1f8a6fb49af 196 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 40 63 4.5E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS25090 b5c459e9d6418694027ef1f8a6fb49af 196 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 19 32 4.5E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS25090 b5c459e9d6418694027ef1f8a6fb49af 196 Gene3D G3DSA:1.10.10.60 4 60 7.2E-19 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS25090 b5c459e9d6418694027ef1f8a6fb49af 196 SUPERFAMILY SSF46689 6 66 2.49E-16 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS25090 b5c459e9d6418694027ef1f8a6fb49af 196 Gene3D G3DSA:1.10.357.10 61 184 5.5E-14 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS25090 b5c459e9d6418694027ef1f8a6fb49af 196 Pfam PF00440 Bacterial regulatory proteins, tetR family 19 64 6.0E-14 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS18230 eb73062f9c7b51532574abd3261645db 111 ProDom PD026347 LSR2-LIKE LSR2 ANTIGEN IMMUNE PRECURSOR RESPONSE SIGNAL PLASMID LYSYL GP61 1 107 8.0E-40 T 09-03-2017 IPR024412 Lsr2 TK78_RS18230 eb73062f9c7b51532574abd3261645db 111 Pfam PF11774 Lsr2 2 109 1.1E-37 T 09-03-2017 IPR024412 Lsr2 TK78_RS11230 5ab4d8943e6c8c959cb8c47444cc2d0e 494 Pfam PF00535 Glycosyl transferase family 2 7 169 5.6E-31 T 09-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 TK78_RS11230 5ab4d8943e6c8c959cb8c47444cc2d0e 494 Pfam PF04138 GtrA-like protein 351 460 3.3E-18 T 09-03-2017 IPR007267 GtrA-like protein GO:0000271|GO:0006810|GO:0016021 TK78_RS11230 5ab4d8943e6c8c959cb8c47444cc2d0e 494 SUPERFAMILY SSF53448 6 230 3.8E-36 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS11230 5ab4d8943e6c8c959cb8c47444cc2d0e 494 Gene3D G3DSA:3.90.550.10 6 131 1.9E-23 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS28970 3e2ab5ee03ce7511b06aaf522cff53b3 269 SMART SM00866 121 261 3.6E-18 T 09-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 TK78_RS28970 3e2ab5ee03ce7511b06aaf522cff53b3 269 Gene3D G3DSA:1.10.10.10 32 104 7.4E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS28970 3e2ab5ee03ce7511b06aaf522cff53b3 269 SUPERFAMILY SSF46785 33 109 2.7E-18 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS28970 3e2ab5ee03ce7511b06aaf522cff53b3 269 SMART SM00345 41 100 1.2E-12 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS28970 3e2ab5ee03ce7511b06aaf522cff53b3 269 SUPERFAMILY SSF64288 88 266 8.17E-34 T 09-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain TK78_RS28970 3e2ab5ee03ce7511b06aaf522cff53b3 269 Pfam PF00392 Bacterial regulatory proteins, gntR family 40 100 3.0E-16 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS28970 3e2ab5ee03ce7511b06aaf522cff53b3 269 Pfam PF07702 UTRA domain 127 260 1.8E-24 T 09-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 TK78_RS28970 3e2ab5ee03ce7511b06aaf522cff53b3 269 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 74 90 3.4E-7 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS28970 3e2ab5ee03ce7511b06aaf522cff53b3 269 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 60 74 3.4E-7 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS28970 3e2ab5ee03ce7511b06aaf522cff53b3 269 Gene3D G3DSA:3.40.1410.10 112 265 9.6E-32 T 09-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain TK78_RS33695 cb5c1b2b32b7c30cfa1c59f80a2725a9 216 Pfam PF00440 Bacterial regulatory proteins, tetR family 33 74 1.7E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS33695 cb5c1b2b32b7c30cfa1c59f80a2725a9 216 Gene3D G3DSA:1.10.10.60 22 70 8.7E-21 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS33695 cb5c1b2b32b7c30cfa1c59f80a2725a9 216 Gene3D G3DSA:1.10.357.10 72 208 2.9E-37 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS33695 cb5c1b2b32b7c30cfa1c59f80a2725a9 216 SUPERFAMILY SSF48498 91 204 1.46E-18 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS33695 cb5c1b2b32b7c30cfa1c59f80a2725a9 216 Pfam PF16859 Bacterial transcriptional repressor C-terminal 89 197 5.0E-23 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS33695 cb5c1b2b32b7c30cfa1c59f80a2725a9 216 SUPERFAMILY SSF46689 23 84 8.48E-14 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS04400 c8503a6b611cae501a5e4e5cabcbf589 177 Gene3D G3DSA:3.40.220.10 8 176 2.4E-61 T 09-03-2017 TK78_RS04400 c8503a6b611cae501a5e4e5cabcbf589 177 Pfam PF01661 Macro domain 25 142 1.6E-40 T 09-03-2017 IPR002589 Macro domain TK78_RS04400 c8503a6b611cae501a5e4e5cabcbf589 177 SUPERFAMILY SSF52949 8 176 8.41E-57 T 09-03-2017 TK78_RS04400 c8503a6b611cae501a5e4e5cabcbf589 177 SMART SM00506 8 142 3.1E-51 T 09-03-2017 IPR002589 Macro domain TK78_RS01440 cd37475980e7a380a9e57e4b2cb5cd24 123 PIRSF PIRSF009151 2 123 7.4E-57 T 09-03-2017 IPR008497 Protein of unknown function DUF779 TK78_RS01440 cd37475980e7a380a9e57e4b2cb5cd24 123 Pfam PF05610 Protein of unknown function (DUF779) 19 118 5.5E-47 T 09-03-2017 IPR008497 Protein of unknown function DUF779 TK78_RS28150 167c6e6ccc6d85f23e793741fa900264 238 SUPERFAMILY SSF52833 1 211 6.71E-41 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS28150 167c6e6ccc6d85f23e793741fa900264 238 Gene3D G3DSA:3.40.30.10 1 209 2.9E-46 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS28150 167c6e6ccc6d85f23e793741fa900264 238 Pfam PF01323 DSBA-like thioredoxin domain 2 205 9.2E-40 T 09-03-2017 IPR001853 DSBA-like thioredoxin domain GO:0015035 Reactome: R-HSA-156590 TK78_RS05845 27dc3c3c8d36ba390d591f63a1d12c23 457 SUPERFAMILY SSF63829 307 450 4.25E-8 T 09-03-2017 TK78_RS05845 27dc3c3c8d36ba390d591f63a1d12c23 457 SUPERFAMILY SSF63829 57 122 4.25E-8 T 09-03-2017 TK78_RS05845 27dc3c3c8d36ba390d591f63a1d12c23 457 Gene3D G3DSA:2.120.10.30 198 445 7.1E-6 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS05845 27dc3c3c8d36ba390d591f63a1d12c23 457 Pfam PF05787 Bacterial protein of unknown function (DUF839) 45 138 1.2E-14 T 09-03-2017 IPR008557 Protein of unknown function DUF839 TK78_RS05845 27dc3c3c8d36ba390d591f63a1d12c23 457 Pfam PF05787 Bacterial protein of unknown function (DUF839) 145 447 4.0E-69 T 09-03-2017 IPR008557 Protein of unknown function DUF839 TK78_RS08655 1a168ce8abce3d1b6651099550bf4921 349 Gene3D G3DSA:3.40.50.300 2 261 8.5E-74 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08655 1a168ce8abce3d1b6651099550bf4921 349 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 239 306 9.9E-18 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS08655 1a168ce8abce3d1b6651099550bf4921 349 Pfam PF00005 ABC transporter 33 187 8.3E-31 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS08655 1a168ce8abce3d1b6651099550bf4921 349 ProSitePatterns PS00211 ABC transporters family signature. 160 174 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS08655 1a168ce8abce3d1b6651099550bf4921 349 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 237 326 6.9E-24 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS08655 1a168ce8abce3d1b6651099550bf4921 349 SMART SM00382 41 237 1.4E-17 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS08655 1a168ce8abce3d1b6651099550bf4921 349 SUPERFAMILY SSF52540 4 258 5.33E-65 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28685 a2c7b135a0080f950476e42c1314153e 258 SUPERFAMILY SSF46785 162 235 4.08E-16 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS28685 a2c7b135a0080f950476e42c1314153e 258 ProSitePatterns PS00893 Nudix box signature. 54 75 - T 09-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 TK78_RS28685 a2c7b135a0080f950476e42c1314153e 258 SUPERFAMILY SSF55811 16 157 5.15E-33 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS28685 a2c7b135a0080f950476e42c1314153e 258 Gene3D G3DSA:1.10.10.10 155 229 4.7E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS28685 a2c7b135a0080f950476e42c1314153e 258 Pfam PF00293 NUDIX domain 24 142 1.0E-18 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS28685 a2c7b135a0080f950476e42c1314153e 258 Gene3D G3DSA:3.90.79.10 8 149 7.9E-49 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS09140 d8a6c59af31ffe013ec5d07c3a95ff84 437 Gene3D G3DSA:2.60.40.360 2 77 4.8E-5 T 09-03-2017 IPR008962 PapD-like TK78_RS26645 7786ae4ac12635de804e96a8324a7503 260 Hamap MF_00719 Adenosylcobinamide-GDP ribazoletransferase [cobS]. 1 260 40.637 T 09-03-2017 IPR003805 Adenosylcobinamide-GDP ribazoletransferase GO:0008818|GO:0009236|GO:0051073 KEGG: 00860+2.7.8.26|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 TK78_RS26645 7786ae4ac12635de804e96a8324a7503 260 Pfam PF02654 Cobalamin-5-phosphate synthase 12 254 1.6E-45 T 09-03-2017 IPR003805 Adenosylcobinamide-GDP ribazoletransferase GO:0008818|GO:0009236|GO:0051073 KEGG: 00860+2.7.8.26|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 TK78_RS24755 027674fd9ec406f0b9869fe0d11d69c3 272 Pfam PF11296 Protein of unknown function (DUF3097) 12 269 1.9E-127 T 09-03-2017 IPR021447 Protein of unknown function DUF3097 TK78_RS00910 2ff8b465ca36a8727c09035f44837848 218 Pfam PF03807 NADP oxidoreductase coenzyme F420-dependent 2 92 5.2E-22 T 09-03-2017 IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal TK78_RS00910 2ff8b465ca36a8727c09035f44837848 218 SUPERFAMILY SSF51735 1 196 1.97E-41 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS00910 2ff8b465ca36a8727c09035f44837848 218 Gene3D G3DSA:3.40.50.720 1 201 2.8E-48 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS15810 81d5fb65bf24dccb03ee03f69c573d2d 292 PRINTS PR00412 Epoxide hydrolase signature 228 244 7.1E-10 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS15810 81d5fb65bf24dccb03ee03f69c573d2d 292 PRINTS PR00412 Epoxide hydrolase signature 113 126 7.1E-10 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS15810 81d5fb65bf24dccb03ee03f69c573d2d 292 PRINTS PR00412 Epoxide hydrolase signature 261 283 7.1E-10 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS15810 81d5fb65bf24dccb03ee03f69c573d2d 292 PRINTS PR00412 Epoxide hydrolase signature 33 51 7.1E-10 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS15810 81d5fb65bf24dccb03ee03f69c573d2d 292 PRINTS PR00412 Epoxide hydrolase signature 99 112 7.1E-10 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS15810 81d5fb65bf24dccb03ee03f69c573d2d 292 SUPERFAMILY SSF53474 3 286 6.12E-74 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS15810 81d5fb65bf24dccb03ee03f69c573d2d 292 PRINTS PR00111 Alpha/beta hydrolase fold signature 230 244 4.2E-5 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS15810 81d5fb65bf24dccb03ee03f69c573d2d 292 PRINTS PR00111 Alpha/beta hydrolase fold signature 52 67 4.2E-5 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS15810 81d5fb65bf24dccb03ee03f69c573d2d 292 Gene3D G3DSA:3.40.50.1820 1 285 1.4E-67 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS15810 81d5fb65bf24dccb03ee03f69c573d2d 292 Pfam PF00561 alpha/beta hydrolase fold 27 270 2.0E-31 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS20445 caee0dab29aed4d67da023fbe4eb3fce 314 Gene3D G3DSA:3.20.20.30 6 313 1.7E-72 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS20445 caee0dab29aed4d67da023fbe4eb3fce 314 TIGRFAM TIGR03619 F420_Rv2161c: probable F420-dependent oxidoreductase, Rv2161c family 39 287 1.8E-69 T 09-03-2017 IPR019921 Luciferase-like, F420-dependent oxidoreductase, Rv2161c, predicted TK78_RS20445 caee0dab29aed4d67da023fbe4eb3fce 314 SUPERFAMILY SSF51679 13 313 2.88E-66 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS20445 caee0dab29aed4d67da023fbe4eb3fce 314 Pfam PF00296 Luciferase-like monooxygenase 27 240 1.2E-52 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS04195 26feed17054a1359d4c31af95867f09a 187 Gene3D G3DSA:3.40.630.30 12 180 7.9E-44 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS04195 26feed17054a1359d4c31af95867f09a 187 SUPERFAMILY SSF55729 14 181 2.48E-29 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS04195 26feed17054a1359d4c31af95867f09a 187 Pfam PF00583 Acetyltransferase (GNAT) family 78 157 8.2E-13 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS30970 b7607068a7bd3e540222ac6924b940a9 329 Gene3D G3DSA:3.40.50.1820 54 308 5.8E-52 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS30970 b7607068a7bd3e540222ac6924b940a9 329 Pfam PF00756 Putative esterase 65 326 1.1E-58 T 09-03-2017 IPR000801 Putative esterase Reactome: R-HSA-156590 TK78_RS30970 b7607068a7bd3e540222ac6924b940a9 329 SUPERFAMILY SSF53474 54 309 1.67E-39 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04055 2b2ae5b013c83329bf77e3c611965ded 312 Pfam PF09362 Domain of unknown function (DUF1996) 80 287 1.8E-50 T 09-03-2017 IPR018535 Domain of unknown function DUF1996 TK78_RS28985 113bb390a180eed32043748196bc62d7 742 Gene3D G3DSA:2.20.25.90 5 63 1.3E-13 T 09-03-2017 TK78_RS28985 113bb390a180eed32043748196bc62d7 742 Pfam PF01568 Molydopterin dinucleotide binding domain 615 732 1.4E-23 T 09-03-2017 IPR006657 Molybdopterin dinucleotide-binding domain GO:0016491|GO:0030151|GO:0055114 TK78_RS28985 113bb390a180eed32043748196bc62d7 742 Pfam PF00384 Molybdopterin oxidoreductase 62 454 7.0E-33 T 09-03-2017 IPR006656 Molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS28985 113bb390a180eed32043748196bc62d7 742 SUPERFAMILY SSF53706 6 659 7.98E-111 T 09-03-2017 TK78_RS28985 113bb390a180eed32043748196bc62d7 742 Gene3D G3DSA:3.40.50.740 64 140 3.4E-44 T 09-03-2017 TK78_RS28985 113bb390a180eed32043748196bc62d7 742 Gene3D G3DSA:3.40.50.740 333 592 3.4E-44 T 09-03-2017 TK78_RS28985 113bb390a180eed32043748196bc62d7 742 Gene3D G3DSA:2.40.40.20 606 741 1.4E-29 T 09-03-2017 TK78_RS28985 113bb390a180eed32043748196bc62d7 742 Gene3D G3DSA:3.40.228.10 149 332 1.6E-49 T 09-03-2017 TK78_RS28985 113bb390a180eed32043748196bc62d7 742 Pfam PF04879 Molybdopterin oxidoreductase Fe4S4 domain 9 52 5.1E-9 T 09-03-2017 IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS28985 113bb390a180eed32043748196bc62d7 742 SMART SM00926 5 58 1.9E-11 T 09-03-2017 IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS28240 36fd18bc681d3424d74d46786f4c92f5 331 TIGRFAM TIGR00380 cobD: cobalamin biosynthesis protein CobD 15 275 2.9E-49 T 09-03-2017 IPR004485 Cobalamin biosynthesis CobD/CbiB GO:0009236|GO:0016021|GO:0048472 TK78_RS28240 36fd18bc681d3424d74d46786f4c92f5 331 Hamap MF_00024 Cobalamin biosynthesis protein CbiB [cbiB]. 1 312 92.482 T 09-03-2017 IPR004485 Cobalamin biosynthesis CobD/CbiB GO:0009236|GO:0016021|GO:0048472 TK78_RS28240 36fd18bc681d3424d74d46786f4c92f5 331 Pfam PF03186 CobD/Cbib protein 13 290 6.5E-85 T 09-03-2017 IPR004485 Cobalamin biosynthesis CobD/CbiB GO:0009236|GO:0016021|GO:0048472 TK78_RS28470 45fb2354b5ec45d393866b4cd4edda28 359 Pfam PF02547 Queuosine biosynthesis protein 6 343 4.3E-71 T 09-03-2017 IPR003699 S-adenosylmethionine:tRNA ribosyltransferase-isomerase, QueA GO:0008616|GO:0016740|GO:0016853 MetaCyc: PWY-6700 TK78_RS28470 45fb2354b5ec45d393866b4cd4edda28 359 SUPERFAMILY SSF111337 5 344 1.57E-70 T 09-03-2017 IPR003699 S-adenosylmethionine:tRNA ribosyltransferase-isomerase, QueA GO:0008616|GO:0016740|GO:0016853 MetaCyc: PWY-6700 TK78_RS28470 45fb2354b5ec45d393866b4cd4edda28 359 Gene3D G3DSA:3.40.1780.10 5 60 3.1E-62 T 09-03-2017 TK78_RS28470 45fb2354b5ec45d393866b4cd4edda28 359 Gene3D G3DSA:3.40.1780.10 187 344 3.1E-62 T 09-03-2017 TK78_RS11120 dd3be22006979df69dd0240bebb26c12 141 Gene3D G3DSA:3.10.450.50 3 130 1.7E-50 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS11120 dd3be22006979df69dd0240bebb26c12 141 Pfam PF12680 SnoaL-like domain 13 118 1.1E-12 T 09-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain TK78_RS11120 dd3be22006979df69dd0240bebb26c12 141 SUPERFAMILY SSF54427 7 129 7.64E-33 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS18395 112fea869ee566bc3bc07d7537055ac2 505 Pfam PF03972 MmgE/PrpD family 33 472 1.5E-124 T 09-03-2017 IPR005656 MmgE/PrpD GO:0016829 TK78_RS18395 112fea869ee566bc3bc07d7537055ac2 505 Gene3D G3DSA:3.30.1330.120 286 425 7.6E-46 T 09-03-2017 TK78_RS18395 112fea869ee566bc3bc07d7537055ac2 505 SUPERFAMILY SSF103378 18 484 2.48E-120 T 09-03-2017 IPR005656 MmgE/PrpD GO:0016829 TK78_RS05265 a87159d28e9e592e803bce0fbba8d838 816 Pfam PF01315 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain 53 160 5.9E-35 T 09-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead TK78_RS05265 a87159d28e9e592e803bce0fbba8d838 816 Gene3D G3DSA:3.30.365.10 320 394 2.0E-42 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS05265 a87159d28e9e592e803bce0fbba8d838 816 Gene3D G3DSA:3.30.365.10 149 212 2.0E-42 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS05265 a87159d28e9e592e803bce0fbba8d838 816 Gene3D G3DSA:3.30.365.10 213 317 2.2E-29 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS05265 a87159d28e9e592e803bce0fbba8d838 816 SUPERFAMILY SSF54665 34 181 1.23E-41 T 09-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead TK78_RS05265 a87159d28e9e592e803bce0fbba8d838 816 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 191 758 2.5E-146 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS05265 a87159d28e9e592e803bce0fbba8d838 816 Gene3D G3DSA:3.90.1170.50 34 148 3.4E-41 T 09-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead TK78_RS05265 a87159d28e9e592e803bce0fbba8d838 816 SUPERFAMILY SSF56003 152 813 5.5E-151 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS05265 a87159d28e9e592e803bce0fbba8d838 816 Gene3D G3DSA:3.30.365.10 502 646 1.4E-26 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS05265 a87159d28e9e592e803bce0fbba8d838 816 Gene3D G3DSA:3.30.365.10 674 813 1.7E-53 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS05265 a87159d28e9e592e803bce0fbba8d838 816 Gene3D G3DSA:3.30.365.10 396 501 1.7E-53 T 09-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 TK78_RS05265 a87159d28e9e592e803bce0fbba8d838 816 SMART SM01008 53 160 1.4E-46 T 09-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead TK78_RS26925 5978a5350fea62c86fe93720436461a0 448 TIGRFAM TIGR01358 DAHP_synth_II: 3-deoxy-7-phosphoheptulonate synthase 10 448 9.3E-234 T 09-03-2017 IPR002480 DAHP synthetase, class II GO:0003849|GO:0009073 KEGG: 00400+2.5.1.54|MetaCyc: PWY-6164 TK78_RS26925 5978a5350fea62c86fe93720436461a0 448 SUPERFAMILY SSF51569 11 446 1.76E-196 T 09-03-2017 TK78_RS26925 5978a5350fea62c86fe93720436461a0 448 Pfam PF01474 Class-II DAHP synthetase family 11 442 3.7E-200 T 09-03-2017 IPR002480 DAHP synthetase, class II GO:0003849|GO:0009073 KEGG: 00400+2.5.1.54|MetaCyc: PWY-6164 TK78_RS03630 26825d4d04eb8bbd5e330dbf21cdb62b 168 Gene3D G3DSA:1.10.10.10 12 160 2.2E-31 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS03630 26825d4d04eb8bbd5e330dbf21cdb62b 168 SMART SM00347 44 145 6.1E-18 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS03630 26825d4d04eb8bbd5e330dbf21cdb62b 168 Pfam PF12802 MarR family 50 108 2.3E-13 T 09-03-2017 TK78_RS03630 26825d4d04eb8bbd5e330dbf21cdb62b 168 SUPERFAMILY SSF46785 17 157 1.95E-27 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS31310 683f38e10bf9fc4c473a0921f084c279 250 SUPERFAMILY SSF48371 43 250 2.19E-51 T 09-03-2017 IPR016024 Armadillo-type fold GO:0005488 TK78_RS31310 683f38e10bf9fc4c473a0921f084c279 250 Gene3D G3DSA:1.25.40.290 158 250 2.7E-32 T 09-03-2017 TK78_RS31310 683f38e10bf9fc4c473a0921f084c279 250 Pfam PF08713 DNA alkylation repair enzyme 41 250 9.7E-61 T 09-03-2017 IPR014825 DNA alkylation repair enzyme TK78_RS24330 50556e5b20d6a5fe765c1feedbb7ec2e 491 ProSitePatterns PS00218 Amino acid permeases signature. 58 88 - T 09-03-2017 IPR004840 Amino acid permease, conserved site GO:0006865|GO:0016021|GO:0055085 TK78_RS24330 50556e5b20d6a5fe765c1feedbb7ec2e 491 PIRSF PIRSF006060 13 475 1.3E-67 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS24330 50556e5b20d6a5fe765c1feedbb7ec2e 491 Pfam PF00324 Amino acid permease 33 437 1.6E-104 T 09-03-2017 IPR004841 Amino acid permease/ SLC12A domain GO:0006810|GO:0016020|GO:0055085 TK78_RS08905 11fc3c76024ddaef71d45b77e7e6d67d 389 Gene3D G3DSA:3.90.1150.10 252 376 5.9E-37 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS08905 11fc3c76024ddaef71d45b77e7e6d67d 389 Pfam PF00266 Aminotransferase class-V 3 372 6.9E-60 T 09-03-2017 IPR000192 Aminotransferase class V domain TK78_RS08905 11fc3c76024ddaef71d45b77e7e6d67d 389 PIRSF PIRSF005572 1 386 2.4E-105 T 09-03-2017 IPR016454 Cysteine desulfurase KEGG: 00730+2.8.1.7|MetaCyc: PWY-6823|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7250 TK78_RS08905 11fc3c76024ddaef71d45b77e7e6d67d 389 Gene3D G3DSA:3.40.640.10 19 251 7.8E-72 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS08905 11fc3c76024ddaef71d45b77e7e6d67d 389 SUPERFAMILY SSF53383 2 381 6.45E-92 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS24505 071bbb8bb3eca5b0a3eb2d7005bb3182 507 SUPERFAMILY SSF53756 174 491 1.47E-38 T 09-03-2017 TK78_RS24505 071bbb8bb3eca5b0a3eb2d7005bb3182 507 Pfam PF00534 Glycosyl transferases group 1 310 464 2.0E-14 T 09-03-2017 IPR001296 Glycosyl transferase, family 1 TK78_RS24505 071bbb8bb3eca5b0a3eb2d7005bb3182 507 Gene3D G3DSA:3.40.50.2000 300 463 4.3E-14 T 09-03-2017 TK78_RS24505 071bbb8bb3eca5b0a3eb2d7005bb3182 507 Pfam PF13439 Glycosyltransferase Family 4 174 286 1.1E-8 T 09-03-2017 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 TK78_RS12635 df1d029c389ca9fe7b5f567bc3cc3a7c 256 Gene3D G3DSA:3.40.50.150 15 252 1.2E-33 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS12635 df1d029c389ca9fe7b5f567bc3cc3a7c 256 Pfam PF13649 Methyltransferase domain 44 144 2.0E-8 T 09-03-2017 TK78_RS12635 df1d029c389ca9fe7b5f567bc3cc3a7c 256 SUPERFAMILY SSF53335 23 222 1.67E-29 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS22810 c2aadf91e91dc837427b58f3fc3c2947 80 Pfam PF04149 Domain of unknown function (DUF397) 26 71 3.6E-6 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS02420 0c297e4dfccff8ac52301192300dca67 250 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 83 94 1.0E-8 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS02420 0c297e4dfccff8ac52301192300dca67 250 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 134 142 1.0E-8 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS02420 0c297e4dfccff8ac52301192300dca67 250 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 155 174 1.0E-8 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS02420 0c297e4dfccff8ac52301192300dca67 250 Gene3D G3DSA:3.40.50.720 1 249 2.3E-75 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS02420 0c297e4dfccff8ac52301192300dca67 250 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 3.3E-37 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS02420 0c297e4dfccff8ac52301192300dca67 250 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 155 174 3.3E-37 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS02420 0c297e4dfccff8ac52301192300dca67 250 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 176 193 3.3E-37 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS02420 0c297e4dfccff8ac52301192300dca67 250 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 212 232 3.3E-37 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS02420 0c297e4dfccff8ac52301192300dca67 250 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 128 144 3.3E-37 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS02420 0c297e4dfccff8ac52301192300dca67 250 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 83 94 3.3E-37 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS02420 0c297e4dfccff8ac52301192300dca67 250 SUPERFAMILY SSF51735 6 248 8.73E-70 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS02420 0c297e4dfccff8ac52301192300dca67 250 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 15 247 8.9E-53 T 09-03-2017 TK78_RS13295 e837d996063472d6ee8472b64bbf39a9 358 Pfam PF02873 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain 220 354 6.2E-37 T 09-03-2017 IPR011601 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal GO:0008762|GO:0055114 KEGG: 00520+1.3.1.98|KEGG: 00550+1.3.1.98|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS13295 e837d996063472d6ee8472b64bbf39a9 358 SUPERFAMILY SSF56176 15 192 1.07E-35 T 09-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 TK78_RS13295 e837d996063472d6ee8472b64bbf39a9 358 SUPERFAMILY SSF56194 218 356 2.22E-32 T 09-03-2017 IPR011601 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal GO:0008762|GO:0055114 KEGG: 00520+1.3.1.98|KEGG: 00550+1.3.1.98|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS13295 e837d996063472d6ee8472b64bbf39a9 358 TIGRFAM TIGR00179 murB: UDP-N-acetylenolpyruvoylglucosamine reductase 16 350 4.9E-44 T 09-03-2017 IPR003170 UDP-N-acetylenolpyruvoylglucosamine reductase GO:0008762|GO:0055114 KEGG: 00520+1.3.1.98|KEGG: 00550+1.3.1.98|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS13295 e837d996063472d6ee8472b64bbf39a9 358 Pfam PF01565 FAD binding domain 30 146 3.9E-20 T 09-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 TK78_RS13295 e837d996063472d6ee8472b64bbf39a9 358 Gene3D G3DSA:3.30.465.10 83 195 2.5E-47 T 09-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 TK78_RS13295 e837d996063472d6ee8472b64bbf39a9 358 Gene3D G3DSA:3.30.465.10 230 246 2.5E-47 T 09-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 TK78_RS13295 e837d996063472d6ee8472b64bbf39a9 358 Gene3D G3DSA:3.90.78.10 247 357 4.8E-43 T 09-03-2017 IPR011601 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal GO:0008762|GO:0055114 KEGG: 00520+1.3.1.98|KEGG: 00550+1.3.1.98|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS13295 e837d996063472d6ee8472b64bbf39a9 358 Gene3D G3DSA:3.30.43.10 15 79 4.2E-23 T 09-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 TK78_RS13295 e837d996063472d6ee8472b64bbf39a9 358 Hamap MF_00037 UDP-N-acetylenolpyruvoylglucosamine reductase [murB]. 1 358 75.722 T 09-03-2017 IPR003170 UDP-N-acetylenolpyruvoylglucosamine reductase GO:0008762|GO:0055114 KEGG: 00520+1.3.1.98|KEGG: 00550+1.3.1.98|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TK78_RS27215 6ed952149639b5ebe976e35094eba7fd 327 SUPERFAMILY SSF52540 24 236 1.15E-57 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27215 6ed952149639b5ebe976e35094eba7fd 327 ProSitePatterns PS00211 ABC transporters family signature. 145 159 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS27215 6ed952149639b5ebe976e35094eba7fd 327 SMART SM00382 38 222 6.0E-12 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS27215 6ed952149639b5ebe976e35094eba7fd 327 Gene3D G3DSA:3.40.50.300 4 239 6.7E-68 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27215 6ed952149639b5ebe976e35094eba7fd 327 Pfam PF00005 ABC transporter 30 172 1.4E-30 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS04020 98cda374c62eb1f879c8032ec41f3bff 320 SUPERFAMILY SSF46785 3 105 3.59E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS04020 98cda374c62eb1f879c8032ec41f3bff 320 Gene3D G3DSA:3.40.190.10 106 185 7.4E-10 T 09-03-2017 TK78_RS04020 98cda374c62eb1f879c8032ec41f3bff 320 Pfam PF03466 LysR substrate binding domain 106 284 2.0E-22 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS04020 98cda374c62eb1f879c8032ec41f3bff 320 Gene3D G3DSA:3.40.190.10 186 268 1.9E-16 T 09-03-2017 TK78_RS04020 98cda374c62eb1f879c8032ec41f3bff 320 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 5 64 3.2E-18 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS04020 98cda374c62eb1f879c8032ec41f3bff 320 Gene3D G3DSA:1.10.10.10 2 83 1.5E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS04020 98cda374c62eb1f879c8032ec41f3bff 320 SUPERFAMILY SSF53850 96 282 1.03E-20 T 09-03-2017 TK78_RS04020 98cda374c62eb1f879c8032ec41f3bff 320 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 20 31 2.6E-8 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS04020 98cda374c62eb1f879c8032ec41f3bff 320 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 41 52 2.6E-8 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS04020 98cda374c62eb1f879c8032ec41f3bff 320 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 31 41 2.6E-8 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS02535 142db90d1f4f2866c8f77da3596e1db3 265 PIRSF PIRSF019254 1 265 1.4E-89 T 09-03-2017 IPR007544 Encapsulating protein for peroxidase GO:0008233|GO:0042742 TK78_RS02535 142db90d1f4f2866c8f77da3596e1db3 265 Pfam PF04454 Encapsulating protein for peroxidase 1 251 1.5E-92 T 09-03-2017 IPR007544 Encapsulating protein for peroxidase GO:0008233|GO:0042742 TK78_RS19880 30fc639889202ee888de484c6e177269 281 Gene3D G3DSA:3.20.20.150 7 265 9.0E-48 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS19880 30fc639889202ee888de484c6e177269 281 Pfam PF01261 Xylose isomerase-like TIM barrel 29 216 3.4E-17 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS19880 30fc639889202ee888de484c6e177269 281 SUPERFAMILY SSF51658 8 269 2.63E-45 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS07155 59d5bc33b393a2fe54f5fa86cc720c9b 964 SMART SM00382 31 178 0.0066 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS07155 59d5bc33b393a2fe54f5fa86cc720c9b 964 Gene3D G3DSA:1.25.40.10 556 750 2.3E-7 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS07155 59d5bc33b393a2fe54f5fa86cc720c9b 964 Pfam PF13191 AAA ATPase domain 20 164 1.1E-13 T 09-03-2017 TK78_RS07155 59d5bc33b393a2fe54f5fa86cc720c9b 964 ProSitePatterns PS00622 LuxR-type HTH domain signature. 900 927 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS07155 59d5bc33b393a2fe54f5fa86cc720c9b 964 Pfam PF00196 Bacterial regulatory proteins, luxR family 885 936 2.9E-9 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS07155 59d5bc33b393a2fe54f5fa86cc720c9b 964 SUPERFAMILY SSF46894 881 936 5.78E-13 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS07155 59d5bc33b393a2fe54f5fa86cc720c9b 964 SMART SM00421 883 940 1.8E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS07155 59d5bc33b393a2fe54f5fa86cc720c9b 964 SUPERFAMILY SSF52540 22 86 1.6E-7 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07155 59d5bc33b393a2fe54f5fa86cc720c9b 964 SUPERFAMILY SSF52540 114 245 1.6E-7 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07155 59d5bc33b393a2fe54f5fa86cc720c9b 964 Gene3D G3DSA:3.40.50.300 31 194 2.3E-5 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07155 59d5bc33b393a2fe54f5fa86cc720c9b 964 Gene3D G3DSA:1.10.10.10 882 937 3.3E-15 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS10360 10dd9e3b25e0454c18ab700e42ee2190 212 SUPERFAMILY SSF56420 36 199 4.19E-54 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS10360 10dd9e3b25e0454c18ab700e42ee2190 212 PIRSF PIRSF004749 14 211 4.0E-45 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS10360 10dd9e3b25e0454c18ab700e42ee2190 212 TIGRFAM TIGR00079 pept_deformyl: peptide deformylase 43 199 1.4E-40 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS10360 10dd9e3b25e0454c18ab700e42ee2190 212 PRINTS PR01576 Peptide deformylase signature 141 159 3.0E-32 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS10360 10dd9e3b25e0454c18ab700e42ee2190 212 PRINTS PR01576 Peptide deformylase signature 67 96 3.0E-32 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS10360 10dd9e3b25e0454c18ab700e42ee2190 212 PRINTS PR01576 Peptide deformylase signature 129 140 3.0E-32 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS10360 10dd9e3b25e0454c18ab700e42ee2190 212 PRINTS PR01576 Peptide deformylase signature 160 189 3.0E-32 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS10360 10dd9e3b25e0454c18ab700e42ee2190 212 Hamap MF_00163 Peptide deformylase [def]. 36 202 28.436 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS10360 10dd9e3b25e0454c18ab700e42ee2190 212 Gene3D G3DSA:3.90.45.10 38 203 1.7E-58 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS10360 10dd9e3b25e0454c18ab700e42ee2190 212 Pfam PF01327 Polypeptide deformylase 38 192 1.3E-45 T 09-03-2017 IPR023635 Peptide deformylase TK78_RS02085 bbb7e2048a6132059ec1cb7a8e2fcdbb 164 SUPERFAMILY SSF46689 1 130 5.79E-19 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS02085 bbb7e2048a6132059ec1cb7a8e2fcdbb 164 Pfam PF13592 Winged helix-turn helix 96 154 6.7E-22 T 09-03-2017 IPR025959 Winged helix-turn helix domain TK78_RS02085 bbb7e2048a6132059ec1cb7a8e2fcdbb 164 Gene3D G3DSA:1.10.10.60 18 88 3.2E-4 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS18690 f5c1af15d49573818ff04ff54e5695a5 112 SUPERFAMILY SSF46955 20 101 2.79E-11 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS18690 f5c1af15d49573818ff04ff54e5695a5 112 SMART SM00422 20 88 1.2E-6 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS18690 f5c1af15d49573818ff04ff54e5695a5 112 Gene3D G3DSA:1.10.1660.10 20 100 9.8E-13 T 09-03-2017 TK78_RS18690 f5c1af15d49573818ff04ff54e5695a5 112 Pfam PF13411 MerR HTH family regulatory protein 20 81 1.2E-9 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS20005 79dbb9b99f42d6309c9fbeb941f93737 253 SUPERFAMILY SSF46785 17 89 2.04E-18 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS20005 79dbb9b99f42d6309c9fbeb941f93737 253 Hamap MF_01131 Redox-sensing transcriptional repressor Rex [rex]. 11 219 36.324 T 09-03-2017 IPR022876 Redox-sensing transcriptional repressor Rex GO:0005737|GO:0045892|GO:0051775 TK78_RS20005 79dbb9b99f42d6309c9fbeb941f93737 253 SUPERFAMILY SSF51735 93 214 4.49E-28 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS20005 79dbb9b99f42d6309c9fbeb941f93737 253 Pfam PF06971 Putative DNA-binding protein N-terminus 16 63 4.1E-19 T 09-03-2017 IPR009718 Rex DNA-binding, C-terminal domain GO:0005737|GO:0045892|GO:0051775 TK78_RS20005 79dbb9b99f42d6309c9fbeb941f93737 253 SMART SM00881 89 190 2.1E-17 T 09-03-2017 IPR003781 CoA-binding GO:0048037 TK78_RS20005 79dbb9b99f42d6309c9fbeb941f93737 253 Gene3D G3DSA:3.40.50.720 88 221 7.7E-50 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS20005 79dbb9b99f42d6309c9fbeb941f93737 253 Pfam PF02629 CoA binding domain 91 188 1.6E-20 T 09-03-2017 IPR003781 CoA-binding GO:0048037 TK78_RS20005 79dbb9b99f42d6309c9fbeb941f93737 253 Gene3D G3DSA:1.10.10.10 15 85 2.5E-30 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS21355 777f0ff443327b32b584594f5e6ecfd2 196 Pfam PF01386 Ribosomal L25p family 6 90 4.3E-25 T 09-03-2017 IPR029751 Ribosomal protein L25 GO:0003735|GO:0005840|GO:0006412|GO:0008097 TK78_RS21355 777f0ff443327b32b584594f5e6ecfd2 196 Pfam PF14693 Ribosomal protein TL5, C-terminal domain 98 178 9.7E-18 T 09-03-2017 IPR020057 Ribosomal protein L25, beta domain TK78_RS21355 777f0ff443327b32b584594f5e6ecfd2 196 Hamap MF_01334 50S ribosomal protein L25 [rplY]. 4 179 25.98 T 09-03-2017 IPR001021 Ribosomal protein L25, long-form GO:0003735|GO:0005840|GO:0006412|GO:0008097 TK78_RS21355 777f0ff443327b32b584594f5e6ecfd2 196 TIGRFAM TIGR00731 bL25_bact_ctc: ribosomal protein bL25, Ctc-form 6 176 2.7E-44 T 09-03-2017 IPR001021 Ribosomal protein L25, long-form GO:0003735|GO:0005840|GO:0006412|GO:0008097 TK78_RS21355 777f0ff443327b32b584594f5e6ecfd2 196 Gene3D G3DSA:2.40.240.10 3 93 1.9E-29 T 09-03-2017 IPR020056 Ribosomal protein L25/Gln-tRNA synthetase, beta-barrel domain Reactome: R-HSA-2408517|Reactome: R-HSA-379716 TK78_RS21355 777f0ff443327b32b584594f5e6ecfd2 196 SUPERFAMILY SSF50715 4 183 2.62E-48 T 09-03-2017 IPR011035 Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain GO:0006412 Reactome: R-HSA-2408517|Reactome: R-HSA-379716 TK78_RS21355 777f0ff443327b32b584594f5e6ecfd2 196 ProDom PD012503 RIBOSOMAL L25 50S RRNA-BINDING RNA-BINDING RIBONUCLEOPROTEIN STRESS GENERAL CTC RRNA 4 89 1.0E-21 T 09-03-2017 IPR029751 Ribosomal protein L25 GO:0003735|GO:0005840|GO:0006412|GO:0008097 TK78_RS21355 777f0ff443327b32b584594f5e6ecfd2 196 Gene3D G3DSA:2.170.120.20 95 184 1.1E-20 T 09-03-2017 IPR020057 Ribosomal protein L25, beta domain TK78_RS30585 b475aafcf3623d6291beffd67c12b3ae 253 SUPERFAMILY SSF51695 12 246 9.94E-63 T 09-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 TK78_RS30585 b475aafcf3623d6291beffd67c12b3ae 253 Gene3D G3DSA:3.20.20.190 9 252 7.3E-76 T 09-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 TK78_RS30585 b475aafcf3623d6291beffd67c12b3ae 253 Pfam PF03009 Glycerophosphoryl diester phosphodiesterase family 18 241 7.7E-37 T 09-03-2017 IPR030395 Glycerophosphodiester phosphodiesterase domain GO:0006629|GO:0008081 TK78_RS10455 2abc97174753b040025256cec5fe2593 338 Pfam PF03193 Protein of unknown function, DUF258 95 271 3.5E-43 T 09-03-2017 IPR010914 RsgA type GTPase domain GO:0003924|GO:0005525 TK78_RS10455 2abc97174753b040025256cec5fe2593 338 TIGRFAM TIGR00157 TIGR00157: ribosome small subunit-dependent GTPase A 71 328 1.1E-43 T 09-03-2017 IPR004881 Ribosome biogenesis GTPase RsgA, putative GO:0003924|GO:0005525 TK78_RS10455 2abc97174753b040025256cec5fe2593 338 Gene3D G3DSA:3.40.50.300 113 271 4.6E-49 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10455 2abc97174753b040025256cec5fe2593 338 SUPERFAMILY SSF52540 113 333 9.48E-41 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10455 2abc97174753b040025256cec5fe2593 338 Hamap MF_01820 Putative ribosome biogenesis GTPase RsgA [rsgA]. 36 336 28.285 T 09-03-2017 IPR004881 Ribosome biogenesis GTPase RsgA, putative GO:0003924|GO:0005525 TK78_RS10455 2abc97174753b040025256cec5fe2593 338 Gene3D G3DSA:1.10.40.50 272 335 1.4E-15 T 09-03-2017 TK78_RS07750 5ede480280c50cf208da005ef8facccd 625 PIRSF PIRSF002741 13 574 4.0E-89 T 09-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 TK78_RS07750 5ede480280c50cf208da005ef8facccd 625 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 98 472 7.1E-81 T 09-03-2017 IPR000914 Solute-binding protein family 5 domain TK78_RS07750 5ede480280c50cf208da005ef8facccd 625 Gene3D G3DSA:3.10.105.10 333 537 3.7E-48 T 09-03-2017 TK78_RS07750 5ede480280c50cf208da005ef8facccd 625 Gene3D G3DSA:3.90.76.10 64 213 1.2E-34 T 09-03-2017 TK78_RS07750 5ede480280c50cf208da005ef8facccd 625 Gene3D G3DSA:3.40.190.10 214 332 2.0E-30 T 09-03-2017 TK78_RS07750 5ede480280c50cf208da005ef8facccd 625 SUPERFAMILY SSF53850 52 571 1.3E-114 T 09-03-2017 TK78_RS05815 b929618f8d4511cf81f1bc83f7ecb0d0 135 SUPERFAMILY SSF51316 6 134 8.72E-56 T 09-03-2017 IPR011057 Mss4-like TK78_RS05815 b929618f8d4511cf81f1bc83f7ecb0d0 135 Pfam PF01641 SelR domain 11 131 4.1E-53 T 09-03-2017 IPR002579 Peptide methionine sulphoxide reductase MrsB GO:0033743|GO:0055114 Reactome: R-HSA-5676934 TK78_RS05815 b929618f8d4511cf81f1bc83f7ecb0d0 135 TIGRFAM TIGR00357 TIGR00357: methionine-R-sulfoxide reductase 7 133 4.1E-49 T 09-03-2017 IPR002579 Peptide methionine sulphoxide reductase MrsB GO:0033743|GO:0055114 Reactome: R-HSA-5676934 TK78_RS05815 b929618f8d4511cf81f1bc83f7ecb0d0 135 Gene3D G3DSA:2.170.150.20 3 134 2.1E-60 T 09-03-2017 IPR002579 Peptide methionine sulphoxide reductase MrsB GO:0033743|GO:0055114 Reactome: R-HSA-5676934 TK78_RS06610 73e7c5efdefe3183f8c09bc46a7f6ea2 333 Pfam PF05544 Proline racemase 10 332 2.2E-136 T 09-03-2017 IPR008794 Proline racemase family TK78_RS06610 73e7c5efdefe3183f8c09bc46a7f6ea2 333 SUPERFAMILY SSF54506 2 331 8.75E-120 T 09-03-2017 TK78_RS06610 73e7c5efdefe3183f8c09bc46a7f6ea2 333 Gene3D G3DSA:3.10.310.10 5 155 5.2E-66 T 09-03-2017 TK78_RS06610 73e7c5efdefe3183f8c09bc46a7f6ea2 333 Gene3D G3DSA:3.10.310.10 156 320 7.3E-63 T 09-03-2017 TK78_RS06610 73e7c5efdefe3183f8c09bc46a7f6ea2 333 PIRSF PIRSF029792 1 333 8.3E-131 T 09-03-2017 IPR008794 Proline racemase family TK78_RS20955 500054621c3d4c513212b71e71cd2f88 1128 Gene3D G3DSA:1.25.40.10 764 965 6.0E-8 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS20955 500054621c3d4c513212b71e71cd2f88 1128 Gene3D G3DSA:1.25.40.10 594 697 6.0E-8 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS22835 44f28d1497cd3c8b9aa60611ed780e54 282 SMART SM00530 16 71 1.3E-9 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS22835 44f28d1497cd3c8b9aa60611ed780e54 282 Pfam PF13560 Helix-turn-helix domain 12 71 2.0E-14 T 09-03-2017 TK78_RS22835 44f28d1497cd3c8b9aa60611ed780e54 282 Gene3D G3DSA:1.10.260.40 6 69 2.3E-10 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS22835 44f28d1497cd3c8b9aa60611ed780e54 282 SUPERFAMILY SSF47413 9 68 4.02E-10 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS20585 9f97c8f681d6f39f0a56c15536bb1b34 285 PIRSF PIRSF029958 2 285 2.1E-94 T 09-03-2017 IPR008701 Necrosis inducing protein TK78_RS20585 9f97c8f681d6f39f0a56c15536bb1b34 285 Pfam PF05630 Necrosis inducing protein (NPP1) 69 273 6.3E-56 T 09-03-2017 IPR008701 Necrosis inducing protein TK78_RS26155 d5f7d5754db178c9944b16d8b2e41145 538 Pfam PF04213 Htaa 280 443 1.6E-48 T 09-03-2017 IPR007331 Htaa TK78_RS26155 d5f7d5754db178c9944b16d8b2e41145 538 Pfam PF04213 Htaa 49 211 1.5E-49 T 09-03-2017 IPR007331 Htaa TK78_RS25155 d0c4d4a18143bc0370b91acb7296ab88 903 Gene3D G3DSA:1.20.80.30 116 202 4.2E-35 T 09-03-2017 TK78_RS25155 d0c4d4a18143bc0370b91acb7296ab88 903 Gene3D G3DSA:3.30.470.20 248 345 9.2E-34 T 09-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 TK78_RS25155 d0c4d4a18143bc0370b91acb7296ab88 903 Pfam PF01326 Pyruvate phosphate dikinase, PEP/pyruvate binding domain 23 75 4.4E-12 T 09-03-2017 IPR002192 Pyruvate phosphate dikinase, PEP/pyruvate-binding GO:0005524|GO:0016301|GO:0016310 TK78_RS25155 d0c4d4a18143bc0370b91acb7296ab88 903 Pfam PF01326 Pyruvate phosphate dikinase, PEP/pyruvate binding domain 66 291 2.6E-31 T 09-03-2017 IPR002192 Pyruvate phosphate dikinase, PEP/pyruvate-binding GO:0005524|GO:0016301|GO:0016310 TK78_RS25155 d0c4d4a18143bc0370b91acb7296ab88 903 Pfam PF01326 Pyruvate phosphate dikinase, PEP/pyruvate binding domain 299 355 1.8E-9 T 09-03-2017 IPR002192 Pyruvate phosphate dikinase, PEP/pyruvate-binding GO:0005524|GO:0016301|GO:0016310 TK78_RS25155 d0c4d4a18143bc0370b91acb7296ab88 903 ProSitePatterns PS00370 PEP-utilizing enzymes phosphorylation site signature. 452 463 - T 09-03-2017 IPR018274 PEP-utilising enzyme, active site GO:0016310|GO:0016772 TK78_RS25155 d0c4d4a18143bc0370b91acb7296ab88 903 Pfam PF02896 PEP-utilising enzyme, TIM barrel domain 539 891 1.7E-85 T 09-03-2017 IPR000121 PEP-utilising enzyme, C-terminal GO:0016310|GO:0016772 TK78_RS25155 d0c4d4a18143bc0370b91acb7296ab88 903 Pfam PF00391 PEP-utilising enzyme, mobile domain 424 505 1.3E-25 T 09-03-2017 IPR008279 PEP-utilising enzyme, mobile domain GO:0016310|GO:0016772 TK78_RS25155 d0c4d4a18143bc0370b91acb7296ab88 903 Gene3D G3DSA:3.20.20.60 552 896 1.6E-128 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS25155 d0c4d4a18143bc0370b91acb7296ab88 903 Gene3D G3DSA:3.50.30.10 403 508 2.5E-39 T 09-03-2017 IPR008279 PEP-utilising enzyme, mobile domain GO:0016310|GO:0016772 TK78_RS25155 d0c4d4a18143bc0370b91acb7296ab88 903 Gene3D G3DSA:1.10.189.10 346 402 2.3E-23 T 09-03-2017 TK78_RS25155 d0c4d4a18143bc0370b91acb7296ab88 903 Gene3D G3DSA:3.30.1490.20 204 247 8.2E-57 T 09-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 TK78_RS25155 d0c4d4a18143bc0370b91acb7296ab88 903 Gene3D G3DSA:3.30.1490.20 9 115 8.2E-57 T 09-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 TK78_RS25155 d0c4d4a18143bc0370b91acb7296ab88 903 SUPERFAMILY SSF51621 541 893 5.5E-113 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS25155 d0c4d4a18143bc0370b91acb7296ab88 903 SUPERFAMILY SSF56059 7 381 7.65E-133 T 09-03-2017 TK78_RS25155 d0c4d4a18143bc0370b91acb7296ab88 903 SUPERFAMILY SSF52009 388 514 2.35E-36 T 09-03-2017 IPR008279 PEP-utilising enzyme, mobile domain GO:0016310|GO:0016772 TK78_RS25155 d0c4d4a18143bc0370b91acb7296ab88 903 PIRSF PIRSF000853 7 903 0.0 T 09-03-2017 IPR010121 Pyruvate, phosphate dikinase GO:0006090|GO:0050242 KEGG: 00620+2.7.9.1|KEGG: 00710+2.7.9.1|KEGG: 00720+2.7.9.1|MetaCyc: PWY-241|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117 TK78_RS25155 d0c4d4a18143bc0370b91acb7296ab88 903 TIGRFAM TIGR01828 pyru_phos_dikin: pyruvate, phosphate dikinase 8 894 0.0 T 09-03-2017 IPR010121 Pyruvate, phosphate dikinase GO:0006090|GO:0050242 KEGG: 00620+2.7.9.1|KEGG: 00710+2.7.9.1|KEGG: 00720+2.7.9.1|MetaCyc: PWY-241|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117 TK78_RS14725 5e5b36df6b1c377a760f58ff902d46d9 820 Pfam PF13625 Helicase conserved C-terminal domain 522 644 6.5E-43 T 09-03-2017 IPR032830 Helicase XPB/Ssl2, N-terminal domain Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167161|Reactome: R-HSA-167162|Reactome: R-HSA-167172|Reactome: R-HSA-167200|Reactome: R-HSA-167246|Reactome: R-HSA-427413|Reactome: R-HSA-5696395|Reactome: R-HSA-5696400|Reactome: R-HSA-674695|Reactome: R-HSA-6781823|Reactome: R-HSA-6781827|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210|Reactome: R-HSA-6796648|Reactome: R-HSA-72086|Reactome: R-HSA-73762|Reactome: R-HSA-73772|Reactome: R-HSA-73776|Reactome: R-HSA-73777|Reactome: R-HSA-73779|Reactome: R-HSA-73863|Reactome: R-HSA-75953|Reactome: R-HSA-75955|Reactome: R-HSA-76042|Reactome: R-HSA-77075 TK78_RS33700 48bb208635292fbf10cf11d5f65d6ee1 539 Pfam PF00005 ABC transporter 362 488 1.4E-22 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS33700 48bb208635292fbf10cf11d5f65d6ee1 539 Pfam PF00005 ABC transporter 20 188 2.5E-26 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS33700 48bb208635292fbf10cf11d5f65d6ee1 539 SMART SM00382 369 533 1.3E-17 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS33700 48bb208635292fbf10cf11d5f65d6ee1 539 SMART SM00382 29 233 8.4E-14 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS33700 48bb208635292fbf10cf11d5f65d6ee1 539 Gene3D G3DSA:3.40.50.300 134 274 1.8E-46 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33700 48bb208635292fbf10cf11d5f65d6ee1 539 Gene3D G3DSA:3.40.50.300 5 101 1.8E-46 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33700 48bb208635292fbf10cf11d5f65d6ee1 539 Gene3D G3DSA:3.40.50.300 362 518 2.2E-37 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33700 48bb208635292fbf10cf11d5f65d6ee1 539 SUPERFAMILY SSF52540 9 236 3.72E-43 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33700 48bb208635292fbf10cf11d5f65d6ee1 539 SUPERFAMILY SSF52540 361 529 4.48E-39 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28170 de4df94cd504ebfc071d9c1f0ab9241e 344 Gene3D G3DSA:3.10.180.10 5 117 2.1E-12 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS28170 de4df94cd504ebfc071d9c1f0ab9241e 344 SUPERFAMILY SSF54593 1 117 5.04E-14 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS28170 de4df94cd504ebfc071d9c1f0ab9241e 344 SUPERFAMILY SSF109854 134 281 3.89E-5 T 09-03-2017 TK78_RS32215 223816b58ae5c5028f10a43e63cd471a 509 Gene3D G3DSA:1.10.275.10 6 201 3.5E-38 T 09-03-2017 IPR024083 Fumarase/histidase, N-terminal TK78_RS32215 223816b58ae5c5028f10a43e63cd471a 509 Pfam PF00221 Aromatic amino acid lyase 24 452 4.9E-114 T 09-03-2017 IPR001106 Aromatic amino acid lyase Reactome: R-HSA-70921 TK78_RS32215 223816b58ae5c5028f10a43e63cd471a 509 SUPERFAMILY SSF48557 13 498 3.69E-115 T 09-03-2017 IPR008948 L-Aspartase-like GO:0003824 TK78_RS32215 223816b58ae5c5028f10a43e63cd471a 509 Gene3D G3DSA:1.20.200.10 202 493 2.5E-72 T 09-03-2017 TK78_RS24595 9119d1c14b8d9271504a32675a16f318 597 Pfam PF13399 LytR cell envelope-related transcriptional attenuator 508 594 1.3E-10 T 09-03-2017 IPR027381 Putative LytR/CpsA/Psr regulator, C-terminal domain TK78_RS24595 9119d1c14b8d9271504a32675a16f318 597 Pfam PF03816 Cell envelope-related transcriptional attenuator domain 270 426 9.7E-6 T 09-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain TK78_RS32205 6f135b77beb3fe59819e246f4b7372a5 216 Gene3D G3DSA:1.10.3720.10 12 193 5.3E-28 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS32205 6f135b77beb3fe59819e246f4b7372a5 216 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 37 198 1.4E-23 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS32205 6f135b77beb3fe59819e246f4b7372a5 216 SUPERFAMILY SSF161098 15 196 5.36E-36 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS02095 3a55dcf56ce90c3c78f0e70d1da032e4 2048 SUPERFAMILY SSF52540 1352 1594 1.15E-7 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24410 b914571b43d18fcb26535e7671bc8e30 227 Gene3D G3DSA:3.90.226.10 29 219 2.8E-73 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS24410 b914571b43d18fcb26535e7671bc8e30 227 SUPERFAMILY SSF52096 36 220 6.08E-61 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS24410 b914571b43d18fcb26535e7671bc8e30 227 ProSitePatterns PS00382 Endopeptidase Clp histidine active site. 137 150 - T 09-03-2017 IPR033135 ClpP, histidine active site TK78_RS24410 b914571b43d18fcb26535e7671bc8e30 227 PRINTS PR00127 Clp protease catalytic subunit P signature 44 59 4.1E-42 T 09-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TK78_RS24410 b914571b43d18fcb26535e7671bc8e30 227 PRINTS PR00127 Clp protease catalytic subunit P signature 84 104 4.1E-42 T 09-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TK78_RS24410 b914571b43d18fcb26535e7671bc8e30 227 PRINTS PR00127 Clp protease catalytic subunit P signature 194 213 4.1E-42 T 09-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TK78_RS24410 b914571b43d18fcb26535e7671bc8e30 227 PRINTS PR00127 Clp protease catalytic subunit P signature 115 132 4.1E-42 T 09-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TK78_RS24410 b914571b43d18fcb26535e7671bc8e30 227 PRINTS PR00127 Clp protease catalytic subunit P signature 136 155 4.1E-42 T 09-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TK78_RS24410 b914571b43d18fcb26535e7671bc8e30 227 Pfam PF00574 Clp protease 38 218 1.1E-75 T 09-03-2017 IPR023562 Clp protease proteolytic subunit /Translocation-enhancing protein TepA TK78_RS24410 b914571b43d18fcb26535e7671bc8e30 227 ProSitePatterns PS00381 Endopeptidase Clp serine active site. 115 126 - T 09-03-2017 IPR018215 ClpP, Ser active site TK78_RS24410 b914571b43d18fcb26535e7671bc8e30 227 Hamap MF_00444 ATP-dependent Clp protease proteolytic subunit [clpP]. 28 219 39.06 T 09-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TK78_RS00995 e785289d35298c84d46a762a52cfcf50 201 SUPERFAMILY SSF53335 9 191 2.43E-30 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS00995 e785289d35298c84d46a762a52cfcf50 201 Gene3D G3DSA:3.40.50.150 9 191 1.4E-31 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS00995 e785289d35298c84d46a762a52cfcf50 201 Pfam PF08241 Methyltransferase domain 48 143 1.6E-18 T 09-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 TK78_RS21405 5c5b123adf3635878e50a8dbf972bca4 383 Gene3D G3DSA:1.10.630.10 1 381 5.2E-103 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS21405 5c5b123adf3635878e50a8dbf972bca4 383 Pfam PF00067 Cytochrome P450 9 347 1.8E-32 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS21405 5c5b123adf3635878e50a8dbf972bca4 383 SUPERFAMILY SSF48264 7 380 8.77E-87 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS21405 5c5b123adf3635878e50a8dbf972bca4 383 PRINTS PR00359 B-class P450 signature 102 118 1.6E-38 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS21405 5c5b123adf3635878e50a8dbf972bca4 383 PRINTS PR00359 B-class P450 signature 163 185 1.6E-38 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS21405 5c5b123adf3635878e50a8dbf972bca4 383 PRINTS PR00359 B-class P450 signature 289 304 1.6E-38 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS21405 5c5b123adf3635878e50a8dbf972bca4 383 PRINTS PR00359 B-class P450 signature 261 288 1.6E-38 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS21405 5c5b123adf3635878e50a8dbf972bca4 383 PRINTS PR00359 B-class P450 signature 244 255 1.6E-38 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS21405 5c5b123adf3635878e50a8dbf972bca4 383 PRINTS PR00359 B-class P450 signature 320 329 1.6E-38 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS21405 5c5b123adf3635878e50a8dbf972bca4 383 PRINTS PR00359 B-class P450 signature 119 134 1.6E-38 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS21405 5c5b123adf3635878e50a8dbf972bca4 383 PRINTS PR00359 B-class P450 signature 329 340 1.6E-38 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS02595 c8fbd951fd74608e3dbf853b2490fcb6 329 SUPERFAMILY SSF161098 89 318 2.75E-57 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS02595 c8fbd951fd74608e3dbf853b2490fcb6 329 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 122 317 1.9E-22 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS02595 c8fbd951fd74608e3dbf853b2490fcb6 329 Gene3D G3DSA:1.20.58.370 42 75 1.3E-5 T 09-03-2017 TK78_RS02595 c8fbd951fd74608e3dbf853b2490fcb6 329 SUPERFAMILY SSF160964 42 75 3.53E-5 T 09-03-2017 TK78_RS02595 c8fbd951fd74608e3dbf853b2490fcb6 329 Gene3D G3DSA:1.10.3720.10 100 327 7.0E-58 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS17020 2761d1dd89e008481c563fb83ada0c6b 303 SMART SM00382 27 213 9.3E-12 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS17020 2761d1dd89e008481c563fb83ada0c6b 303 SUPERFAMILY SSF52540 3 216 1.78E-52 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17020 2761d1dd89e008481c563fb83ada0c6b 303 Pfam PF00005 ABC transporter 20 157 1.8E-26 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS17020 2761d1dd89e008481c563fb83ada0c6b 303 Gene3D G3DSA:3.40.50.300 3 217 1.6E-55 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17020 2761d1dd89e008481c563fb83ada0c6b 303 ProSitePatterns PS00211 ABC transporters family signature. 129 143 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS19670 fde31ec8b25deaa1486008230b1377fc 286 Gene3D G3DSA:3.20.20.20 17 283 9.0E-107 T 09-03-2017 IPR000489 Pterin-binding domain GO:0042558 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TK78_RS19670 fde31ec8b25deaa1486008230b1377fc 286 ProSitePatterns PS00792 Dihydropteroate synthase signature 1. 21 36 - T 09-03-2017 IPR000489 Pterin-binding domain GO:0042558 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TK78_RS19670 fde31ec8b25deaa1486008230b1377fc 286 SUPERFAMILY SSF51717 19 282 1.26E-92 T 09-03-2017 IPR011005 Dihydropteroate synthase-like GO:0044237 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TK78_RS19670 fde31ec8b25deaa1486008230b1377fc 286 ProSitePatterns PS00793 Dihydropteroate synthase signature 2. 55 68 - T 09-03-2017 IPR000489 Pterin-binding domain GO:0042558 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TK78_RS19670 fde31ec8b25deaa1486008230b1377fc 286 TIGRFAM TIGR01496 DHPS: dihydropteroate synthase 21 281 3.6E-92 T 09-03-2017 IPR006390 Dihydropteroate synthase GO:0004156|GO:0009396 KEGG: 00790+2.5.1.15|MetaCyc: PWY-6614 TK78_RS19670 fde31ec8b25deaa1486008230b1377fc 286 Pfam PF00809 Pterin binding enzyme 22 267 1.8E-83 T 09-03-2017 IPR000489 Pterin-binding domain GO:0042558 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TK78_RS13885 1d0af9ddc1f2ed98c1e3a741f19deac2 353 Gene3D G3DSA:1.10.3470.10 36 353 8.6E-78 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS13885 1d0af9ddc1f2ed98c1e3a741f19deac2 353 Pfam PF01032 FecCD transport family 54 348 1.1E-69 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS13885 1d0af9ddc1f2ed98c1e3a741f19deac2 353 SUPERFAMILY SSF81345 32 349 9.15E-59 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS07845 512ff777ee7f391bf35af841fce64577 174 SUPERFAMILY SSF47240 16 152 4.62E-37 T 09-03-2017 IPR009078 Ferritin-like superfamily TK78_RS07845 512ff777ee7f391bf35af841fce64577 174 Gene3D G3DSA:1.20.1260.10 17 142 8.7E-43 T 09-03-2017 IPR012347 Ferritin-related TK78_RS07845 512ff777ee7f391bf35af841fce64577 174 Pfam PF14530 Domain of unknown function (DUF4439) 22 152 1.7E-43 T 09-03-2017 IPR029447 Domain of unknown function DUF4439 TK78_RS22315 23d80737769ea3d14f84f3734e615618 443 Pfam PF07690 Major Facilitator Superfamily 39 387 3.0E-23 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS22315 23d80737769ea3d14f84f3734e615618 443 Gene3D G3DSA:1.20.1250.20 23 213 7.4E-15 T 09-03-2017 TK78_RS22315 23d80737769ea3d14f84f3734e615618 443 Gene3D G3DSA:1.20.1250.20 226 425 1.6E-16 T 09-03-2017 TK78_RS22315 23d80737769ea3d14f84f3734e615618 443 SUPERFAMILY SSF103473 9 431 2.62E-45 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS02580 25ed6ef4e2bd8a3f631ed6802e3cfdfc 99 Pfam PF13466 STAS domain 1 73 5.8E-8 T 09-03-2017 IPR002645 STAS domain TK78_RS02580 25ed6ef4e2bd8a3f631ed6802e3cfdfc 99 Gene3D G3DSA:3.30.750.24 1 91 3.1E-13 T 09-03-2017 IPR002645 STAS domain TK78_RS02580 25ed6ef4e2bd8a3f631ed6802e3cfdfc 99 SUPERFAMILY SSF52091 1 90 5.89E-12 T 09-03-2017 IPR002645 STAS domain TK78_RS07835 23602fd3fc1a252b0aa410c05a458e3b 167 SUPERFAMILY SSF74942 86 157 1.83E-5 T 09-03-2017 IPR028998 Ribosome maturation factor RimP, C-terminal TK78_RS07835 23602fd3fc1a252b0aa410c05a458e3b 167 Gene3D G3DSA:3.30.300.70 3 82 5.4E-25 T 09-03-2017 IPR028989 Ribosome maturation factor RimP, N-terminal TK78_RS07835 23602fd3fc1a252b0aa410c05a458e3b 167 Pfam PF02576 Putative ribosome maturation factor RimP 12 153 4.5E-39 T 09-03-2017 IPR003728 Ribosome maturation factor RimP GO:0042274 TK78_RS07835 23602fd3fc1a252b0aa410c05a458e3b 167 SUPERFAMILY SSF75420 3 85 2.35E-20 T 09-03-2017 IPR028989 Ribosome maturation factor RimP, N-terminal TK78_RS07835 23602fd3fc1a252b0aa410c05a458e3b 167 Hamap MF_01077 Ribosome maturation factor RimP [rimP]. 7 157 22.948 T 09-03-2017 IPR003728 Ribosome maturation factor RimP GO:0042274 TK78_RS08005 a53a56209add4e13de22b2184a5c6f0e 459 SUPERFAMILY SSF53383 15 454 2.45E-127 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS08005 a53a56209add4e13de22b2184a5c6f0e 459 Gene3D G3DSA:3.40.640.10 71 345 3.5E-84 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS08005 a53a56209add4e13de22b2184a5c6f0e 459 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 257 294 - T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS08005 a53a56209add4e13de22b2184a5c6f0e 459 Pfam PF00202 Aminotransferase class-III 35 451 1.9E-101 T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS08005 a53a56209add4e13de22b2184a5c6f0e 459 Gene3D G3DSA:3.90.1150.10 346 454 5.3E-36 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS08005 a53a56209add4e13de22b2184a5c6f0e 459 Gene3D G3DSA:3.90.1150.10 10 69 5.3E-36 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS04435 d3781ceee0866e248c5eb989545dfa74 447 Pfam PF08402 TOBE domain 286 341 2.7E-5 T 09-03-2017 IPR013611 Transport-associated OB, type 2 GO:0005215|GO:0005524|GO:0006810|GO:0016820|GO:0043190 TK78_RS04435 d3781ceee0866e248c5eb989545dfa74 447 Pfam PF00005 ABC transporter 21 161 1.2E-27 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS04435 d3781ceee0866e248c5eb989545dfa74 447 ProSitePatterns PS00211 ABC transporters family signature. 134 148 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS04435 d3781ceee0866e248c5eb989545dfa74 447 SUPERFAMILY SSF50331 236 332 1.19E-11 T 09-03-2017 IPR008995 Molybdate/tungstate binding, C-terminal TK78_RS04435 d3781ceee0866e248c5eb989545dfa74 447 SMART SM00382 29 211 9.3E-15 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS04435 d3781ceee0866e248c5eb989545dfa74 447 SUPERFAMILY SSF52540 5 241 6.1E-78 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS04435 d3781ceee0866e248c5eb989545dfa74 447 Gene3D G3DSA:3.40.50.300 3 233 3.8E-70 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS04435 d3781ceee0866e248c5eb989545dfa74 447 Gene3D G3DSA:2.40.50.140 290 331 3.0E-4 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS00255 15e7aaa115d0432dc7848cd5c6884691 128 Pfam PF12680 SnoaL-like domain 19 108 6.1E-11 T 09-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain TK78_RS00255 15e7aaa115d0432dc7848cd5c6884691 128 SUPERFAMILY SSF54427 12 114 7.57E-21 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS00255 15e7aaa115d0432dc7848cd5c6884691 128 Gene3D G3DSA:3.10.450.50 19 115 3.5E-8 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS21255 3ab3047422a4823705dc3a770d2ac793 641 Gene3D G3DSA:2.140.10.10 211 588 9.0E-17 T 09-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain TK78_RS21255 3ab3047422a4823705dc3a770d2ac793 641 Gene3D G3DSA:2.140.10.10 171 178 9.0E-17 T 09-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain TK78_RS21255 3ab3047422a4823705dc3a770d2ac793 641 SUPERFAMILY SSF50998 278 548 2.35E-16 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS21255 3ab3047422a4823705dc3a770d2ac793 641 Pfam PF13360 PQQ-like domain 250 382 8.1E-11 T 09-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat TK78_RS33370 40e586ef0a51c7854a1764f04d009710 177 Gene3D G3DSA:3.10.129.10 19 160 1.8E-49 T 09-03-2017 IPR029069 HotDog domain TK78_RS33370 40e586ef0a51c7854a1764f04d009710 177 SUPERFAMILY SSF54637 22 168 2.21E-35 T 09-03-2017 IPR029069 HotDog domain TK78_RS33370 40e586ef0a51c7854a1764f04d009710 177 Pfam PF13279 Thioesterase-like superfamily 26 154 2.1E-18 T 09-03-2017 TK78_RS14295 ce14641573d00a96faa25471897ec5f0 126 SUPERFAMILY SSF52980 8 83 3.06E-5 T 09-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 TK78_RS14295 ce14641573d00a96faa25471897ec5f0 126 Gene3D G3DSA:3.90.1570.10 2 82 1.0E-5 T 09-03-2017 IPR012296 Nuclease, putative, TT1808 TK78_RS14295 ce14641573d00a96faa25471897ec5f0 126 Pfam PF05685 Putative restriction endonuclease 3 115 2.6E-18 T 09-03-2017 IPR008538 Domain of unknown function DUF820 TK78_RS09205 1eb34618418502b63b93c33a8d36b976 325 SUPERFAMILY SSF48576 9 301 2.24E-41 T 09-03-2017 IPR008949 Isoprenoid synthase domain TK78_RS09205 1eb34618418502b63b93c33a8d36b976 325 Gene3D G3DSA:1.10.600.10 2 301 6.7E-73 T 09-03-2017 IPR008949 Isoprenoid synthase domain TK78_RS09305 ec8a9f8271bdc7c4143ecb58f27d1085 237 SUPERFAMILY SSF81301 3 80 4.73E-8 T 09-03-2017 TK78_RS09305 ec8a9f8271bdc7c4143ecb58f27d1085 237 Gene3D G3DSA:3.30.460.10 11 75 1.2E-7 T 09-03-2017 TK78_RS24865 95c29f093121619f4b640e1cae98df4f 234 Pfam PF05099 Tellurite resistance protein TerB 86 225 7.5E-10 T 09-03-2017 IPR007791 Co-chaperone DjlA, N-terminal TK78_RS24865 95c29f093121619f4b640e1cae98df4f 234 Gene3D G3DSA:1.10.3680.10 178 227 2.2E-5 T 09-03-2017 IPR029024 TerB-like TK78_RS24865 95c29f093121619f4b640e1cae98df4f 234 SUPERFAMILY SSF158682 89 229 5.1E-9 T 09-03-2017 IPR029024 TerB-like TK78_RS02265 ed59de9859bb97648bf5287160bcad8c 402 Pfam PF09587 Bacterial capsule synthesis protein PGA_cap 55 307 2.3E-68 T 09-03-2017 IPR019079 Capsule synthesis protein, CapA TK78_RS02265 ed59de9859bb97648bf5287160bcad8c 402 Gene3D G3DSA:3.60.21.10 84 299 2.6E-18 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS02265 ed59de9859bb97648bf5287160bcad8c 402 SMART SM00854 55 309 5.5E-80 T 09-03-2017 IPR019079 Capsule synthesis protein, CapA TK78_RS02265 ed59de9859bb97648bf5287160bcad8c 402 SUPERFAMILY SSF56300 55 362 1.57E-33 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS33440 95aa200af9e870c8b8245310a877412c 330 Gene3D G3DSA:3.40.50.10440 11 181 2.7E-70 T 09-03-2017 TK78_RS33440 95aa200af9e870c8b8245310a877412c 330 Pfam PF02733 Dak1 domain 17 324 9.9E-124 T 09-03-2017 IPR004006 DhaK domain GO:0004371|GO:0006071 Reactome: R-HSA-168928|Reactome: R-HSA-70350 TK78_RS33440 95aa200af9e870c8b8245310a877412c 330 SUPERFAMILY SSF82549 11 329 5.75E-117 T 09-03-2017 TK78_RS33440 95aa200af9e870c8b8245310a877412c 330 TIGRFAM TIGR02363 dhaK1: dihydroxyacetone kinase, DhaK subunit 1 326 5.5E-148 T 09-03-2017 IPR012736 Dihydroxyacetone kinase DhaK, subunit 1 TK78_RS33440 95aa200af9e870c8b8245310a877412c 330 Gene3D G3DSA:3.30.1180.20 185 329 1.2E-51 T 09-03-2017 TK78_RS13480 1555ab04defa6d0c362a23e7ae7c91c7 218 Pfam PF11706 CGNR zinc finger 163 205 5.4E-21 T 09-03-2017 IPR021005 Zinc finger, CGNR TK78_RS13480 1555ab04defa6d0c362a23e7ae7c91c7 218 Pfam PF07336 Putative stress-induced transcription regulator 26 158 5.0E-23 T 09-03-2017 IPR010852 Putative stress-induced transcription regulator TK78_RS13480 1555ab04defa6d0c362a23e7ae7c91c7 218 Gene3D G3DSA:1.10.3300.10 20 205 4.4E-50 T 09-03-2017 IPR023286 ABATE domain TK78_RS13480 1555ab04defa6d0c362a23e7ae7c91c7 218 SUPERFAMILY SSF160904 20 205 2.09E-46 T 09-03-2017 TK78_RS18655 b356e818fccd8ed194bf7a9aa8da2e1c 378 Gene3D G3DSA:3.40.190.10 143 307 8.1E-53 T 09-03-2017 TK78_RS18655 b356e818fccd8ed194bf7a9aa8da2e1c 378 SUPERFAMILY SSF53850 59 378 4.35E-84 T 09-03-2017 TK78_RS18655 b356e818fccd8ed194bf7a9aa8da2e1c 378 PIRSF PIRSF002756 10 378 4.0E-110 T 09-03-2017 IPR005673 ABC transporter, phosphate-binding protein PstS GO:0035435|GO:0042301|GO:0043190 TK78_RS18655 b356e818fccd8ed194bf7a9aa8da2e1c 378 Gene3D G3DSA:3.40.190.10 56 126 9.0E-5 T 09-03-2017 TK78_RS18655 b356e818fccd8ed194bf7a9aa8da2e1c 378 TIGRFAM TIGR00975 3a0107s03: phosphate ABC transporter, phosphate-binding protein PstS 60 375 1.4E-77 T 09-03-2017 IPR005673 ABC transporter, phosphate-binding protein PstS GO:0035435|GO:0042301|GO:0043190 TK78_RS18655 b356e818fccd8ed194bf7a9aa8da2e1c 378 Pfam PF12849 PBP superfamily domain 55 348 6.7E-55 T 09-03-2017 IPR024370 PBP domain TK78_RS18655 b356e818fccd8ed194bf7a9aa8da2e1c 378 Gene3D G3DSA:3.40.190.10 308 372 7.5E-6 T 09-03-2017 TK78_RS09810 0317c6088a1006469eb6c5713775ddce 309 SUPERFAMILY SSF116734 21 99 2.45E-6 T 09-03-2017 TK78_RS09810 0317c6088a1006469eb6c5713775ddce 309 SUPERFAMILY SSF116734 110 295 9.97E-8 T 09-03-2017 TK78_RS27735 df114a17c4f496b09844bbd48372d2a1 215 Pfam PF13529 Peptidase_C39 like family 51 173 1.7E-5 T 09-03-2017 TK78_RS28260 eeae2a275f3c1722fedb04036d919b27 375 Gene3D G3DSA:3.40.50.1820 304 371 4.4E-26 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS28260 eeae2a275f3c1722fedb04036d919b27 375 Gene3D G3DSA:3.40.50.1820 131 266 4.4E-26 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS28260 eeae2a275f3c1722fedb04036d919b27 375 SUPERFAMILY SSF53474 131 268 3.81E-30 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS28260 eeae2a275f3c1722fedb04036d919b27 375 SUPERFAMILY SSF53474 306 371 3.81E-30 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS25395 e8ce81bd0df2efd20061a67a1db9894d 345 Pfam PF06723 MreB/Mbl protein 11 332 3.8E-108 T 09-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 TK78_RS25395 e8ce81bd0df2efd20061a67a1db9894d 345 Gene3D G3DSA:3.30.420.40 265 319 5.7E-23 T 09-03-2017 TK78_RS25395 e8ce81bd0df2efd20061a67a1db9894d 345 Gene3D G3DSA:3.30.420.40 160 187 5.7E-23 T 09-03-2017 TK78_RS25395 e8ce81bd0df2efd20061a67a1db9894d 345 Gene3D G3DSA:3.90.640.10 188 261 2.1E-12 T 09-03-2017 TK78_RS25395 e8ce81bd0df2efd20061a67a1db9894d 345 SUPERFAMILY SSF53067 11 149 3.72E-21 T 09-03-2017 TK78_RS25395 e8ce81bd0df2efd20061a67a1db9894d 345 Gene3D G3DSA:3.30.420.40 12 159 1.2E-21 T 09-03-2017 TK78_RS25395 e8ce81bd0df2efd20061a67a1db9894d 345 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 48 66 1.0E-36 T 09-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 TK78_RS25395 e8ce81bd0df2efd20061a67a1db9894d 345 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 302 328 1.0E-36 T 09-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 TK78_RS25395 e8ce81bd0df2efd20061a67a1db9894d 345 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 68 91 1.0E-36 T 09-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 TK78_RS25395 e8ce81bd0df2efd20061a67a1db9894d 345 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 188 208 1.0E-36 T 09-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 TK78_RS25395 e8ce81bd0df2efd20061a67a1db9894d 345 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 133 152 1.0E-36 T 09-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 TK78_RS25395 e8ce81bd0df2efd20061a67a1db9894d 345 SUPERFAMILY SSF53067 150 330 1.84E-31 T 09-03-2017 TK78_RS03705 c00321a788aea5c1acf7cb78cc8d6222 661 Gene3D G3DSA:1.10.3720.10 145 326 8.9E-29 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS03705 c00321a788aea5c1acf7cb78cc8d6222 661 Gene3D G3DSA:1.10.3720.10 464 645 1.5E-30 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS03705 c00321a788aea5c1acf7cb78cc8d6222 661 SUPERFAMILY SSF161098 147 329 6.54E-34 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS03705 c00321a788aea5c1acf7cb78cc8d6222 661 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 169 337 7.9E-18 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS03705 c00321a788aea5c1acf7cb78cc8d6222 661 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 488 641 5.0E-19 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS03705 c00321a788aea5c1acf7cb78cc8d6222 661 SUPERFAMILY SSF161098 467 650 8.5E-32 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS25865 a35380257d6ba89767ef2041c63b2258 374 Gene3D G3DSA:2.60.120.620 35 288 1.6E-33 T 09-03-2017 TK78_RS25865 a35380257d6ba89767ef2041c63b2258 374 Pfam PF05721 Phytanoyl-CoA dioxygenase (PhyH) 58 273 6.9E-10 T 09-03-2017 IPR008775 Phytanoyl-CoA dioxygenase TK78_RS25865 a35380257d6ba89767ef2041c63b2258 374 SUPERFAMILY SSF51197 47 340 3.74E-58 T 09-03-2017 TK78_RS16120 e005ce4acf76b2f3ee57389401c56e5e 166 SUPERFAMILY SSF53271 9 152 5.79E-26 T 09-03-2017 IPR029057 Phosphoribosyltransferase-like TK78_RS16120 e005ce4acf76b2f3ee57389401c56e5e 166 Gene3D G3DSA:3.40.50.2020 10 154 1.5E-32 T 09-03-2017 IPR029057 Phosphoribosyltransferase-like TK78_RS16120 e005ce4acf76b2f3ee57389401c56e5e 166 Pfam PF00156 Phosphoribosyl transferase domain 15 153 1.0E-23 T 09-03-2017 IPR000836 Phosphoribosyltransferase domain GO:0009116 TK78_RS05930 2c80d4e1c81325e3dbad5cf6ec8a173a 232 SUPERFAMILY SSF47240 22 193 3.25E-21 T 09-03-2017 IPR009078 Ferritin-like superfamily TK78_RS05930 2c80d4e1c81325e3dbad5cf6ec8a173a 232 Gene3D G3DSA:1.20.1260.10 60 161 6.7E-5 T 09-03-2017 IPR012347 Ferritin-related TK78_RS07730 22fd2710c9ff70fbbfea907e94b84224 454 TIGRFAM TIGR03923 T7SS_EccE: type VII secretion protein EccE 65 453 1.1E-57 T 09-03-2017 IPR021368 Type VII secretion system protein EccE TK78_RS07730 22fd2710c9ff70fbbfea907e94b84224 454 Pfam PF11203 Putative type VII ESX secretion system translocon, EccE 247 356 3.3E-29 T 09-03-2017 IPR021368 Type VII secretion system protein EccE TK78_RS16605 b4a31cf99a19b86978543ef54eead3b2 170 PRINTS PR00598 Bacterial regulatory protein MarR family signature 66 81 2.4E-6 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS16605 b4a31cf99a19b86978543ef54eead3b2 170 PRINTS PR00598 Bacterial regulatory protein MarR family signature 85 101 2.4E-6 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS16605 b4a31cf99a19b86978543ef54eead3b2 170 PRINTS PR00598 Bacterial regulatory protein MarR family signature 115 135 2.4E-6 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS16605 b4a31cf99a19b86978543ef54eead3b2 170 PRINTS PR00598 Bacterial regulatory protein MarR family signature 49 65 2.4E-6 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS16605 b4a31cf99a19b86978543ef54eead3b2 170 Gene3D G3DSA:1.10.10.10 22 139 3.2E-27 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS16605 b4a31cf99a19b86978543ef54eead3b2 170 Pfam PF01047 MarR family 38 89 2.7E-12 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS16605 b4a31cf99a19b86978543ef54eead3b2 170 SUPERFAMILY SSF46785 35 138 2.42E-24 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS16605 b4a31cf99a19b86978543ef54eead3b2 170 SMART SM00347 25 125 1.1E-11 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS00945 65ce59b4f6475c8cb176c967246aeb06 233 SMART SM00855 2 157 8.3E-17 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS00945 65ce59b4f6475c8cb176c967246aeb06 233 Gene3D G3DSA:3.40.50.1240 1 192 2.6E-39 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS00945 65ce59b4f6475c8cb176c967246aeb06 233 SUPERFAMILY SSF53254 1 196 1.02E-39 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS00945 65ce59b4f6475c8cb176c967246aeb06 233 ProSitePatterns PS00175 Phosphoglycerate mutase family phosphohistidine signature. 5 14 - T 09-03-2017 IPR001345 Phosphoglycerate/bisphosphoglycerate mutase, active site GO:0003824|GO:0008152 TK78_RS00945 65ce59b4f6475c8cb176c967246aeb06 233 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 3 196 1.4E-42 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS12910 7cbfa640e50d52022e9ade626ce52e68 362 SUPERFAMILY SSF53474 2 355 1.09E-99 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS12910 7cbfa640e50d52022e9ade626ce52e68 362 PRINTS PR00412 Epoxide hydrolase signature 176 189 1.4E-9 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS12910 7cbfa640e50d52022e9ade626ce52e68 362 PRINTS PR00412 Epoxide hydrolase signature 98 116 1.4E-9 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS12910 7cbfa640e50d52022e9ade626ce52e68 362 PRINTS PR00412 Epoxide hydrolase signature 301 317 1.4E-9 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS12910 7cbfa640e50d52022e9ade626ce52e68 362 PRINTS PR00412 Epoxide hydrolase signature 162 175 1.4E-9 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS12910 7cbfa640e50d52022e9ade626ce52e68 362 PRINTS PR00412 Epoxide hydrolase signature 332 354 1.4E-9 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS12910 7cbfa640e50d52022e9ade626ce52e68 362 PIRSF PIRSF001112 1 360 4.1E-109 T 09-03-2017 IPR016292 Epoxide hydrolase GO:0033961 KEGG: 00980+3.3.2.9|Reactome: R-HSA-211945 TK78_RS12910 7cbfa640e50d52022e9ade626ce52e68 362 Pfam PF06441 Epoxide hydrolase N terminus 2 107 1.4E-38 T 09-03-2017 IPR010497 Epoxide hydrolase, N-terminal KEGG: 00980+3.3.2.9|Reactome: R-HSA-211945 TK78_RS12910 7cbfa640e50d52022e9ade626ce52e68 362 Gene3D G3DSA:3.40.50.1820 2 355 1.1E-138 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS01615 a3a3cf0db8e1e8a30e7174fd7a225c5d 493 Pfam PF02397 Bacterial sugar transferase 307 488 4.5E-51 T 09-03-2017 IPR003362 Bacterial sugar transferase TK78_RS01615 a3a3cf0db8e1e8a30e7174fd7a225c5d 493 TIGRFAM TIGR03025 EPS_sugtrans: exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase 72 489 1.9E-102 T 09-03-2017 IPR017475 Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase TK78_RS17465 7ea9e2aacfbcb7acbd4f517689c6a2c6 175 PRINTS PR00153 Cyclophilin peptidyl-prolyl cis-trans isomerase signature 61 73 5.1E-26 T 09-03-2017 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 TK78_RS17465 7ea9e2aacfbcb7acbd4f517689c6a2c6 175 PRINTS PR00153 Cyclophilin peptidyl-prolyl cis-trans isomerase signature 20 35 5.1E-26 T 09-03-2017 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 TK78_RS17465 7ea9e2aacfbcb7acbd4f517689c6a2c6 175 PRINTS PR00153 Cyclophilin peptidyl-prolyl cis-trans isomerase signature 129 144 5.1E-26 T 09-03-2017 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 TK78_RS17465 7ea9e2aacfbcb7acbd4f517689c6a2c6 175 PRINTS PR00153 Cyclophilin peptidyl-prolyl cis-trans isomerase signature 116 128 5.1E-26 T 09-03-2017 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 TK78_RS17465 7ea9e2aacfbcb7acbd4f517689c6a2c6 175 PRINTS PR00153 Cyclophilin peptidyl-prolyl cis-trans isomerase signature 101 116 5.1E-26 T 09-03-2017 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 TK78_RS17465 7ea9e2aacfbcb7acbd4f517689c6a2c6 175 PIRSF PIRSF001467 1 175 3.4E-54 T 09-03-2017 IPR024936 Cyclophilin-type peptidyl-prolyl cis-trans isomerase GO:0003755|GO:0006457 TK78_RS17465 7ea9e2aacfbcb7acbd4f517689c6a2c6 175 Gene3D G3DSA:2.40.100.10 4 172 8.8E-60 T 09-03-2017 IPR029000 Cyclophilin-like domain TK78_RS17465 7ea9e2aacfbcb7acbd4f517689c6a2c6 175 ProSitePatterns PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 56 73 - T 09-03-2017 IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site GO:0003755|GO:0006457 TK78_RS17465 7ea9e2aacfbcb7acbd4f517689c6a2c6 175 Pfam PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD 7 171 1.0E-42 T 09-03-2017 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 TK78_RS17465 7ea9e2aacfbcb7acbd4f517689c6a2c6 175 SUPERFAMILY SSF50891 6 171 3.36E-58 T 09-03-2017 IPR029000 Cyclophilin-like domain TK78_RS25930 8e8c847865285a4bfa7c68aacf3a0b1e 292 Gene3D G3DSA:3.40.630.40 74 291 2.1E-35 T 09-03-2017 IPR002508 N-acetylmuramoyl-L-alanine amidase, catalytic domain GO:0008745|GO:0009253 TK78_RS25930 8e8c847865285a4bfa7c68aacf3a0b1e 292 SUPERFAMILY SSF53187 73 290 1.32E-31 T 09-03-2017 TK78_RS25930 8e8c847865285a4bfa7c68aacf3a0b1e 292 Pfam PF01520 N-acetylmuramoyl-L-alanine amidase 76 287 6.5E-36 T 09-03-2017 IPR002508 N-acetylmuramoyl-L-alanine amidase, catalytic domain GO:0008745|GO:0009253 TK78_RS25930 8e8c847865285a4bfa7c68aacf3a0b1e 292 SMART SM00646 159 287 2.3E-17 T 09-03-2017 IPR002508 N-acetylmuramoyl-L-alanine amidase, catalytic domain GO:0008745|GO:0009253 TK78_RS33285 649ac966fea5efa94b6117da92ff86a6 190 Pfam PF03551 Transcriptional regulator PadR-like family 7 80 1.1E-10 T 09-03-2017 IPR005149 Transcription regulator PadR, N-terminal TK78_RS33285 649ac966fea5efa94b6117da92ff86a6 190 SUPERFAMILY SSF46785 3 182 7.61E-34 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS33285 649ac966fea5efa94b6117da92ff86a6 190 Pfam PF10400 Virulence activator alpha C-term 92 181 6.9E-17 T 09-03-2017 IPR018309 Transcription regulator PadR, C-terminal TK78_RS33285 649ac966fea5efa94b6117da92ff86a6 190 Gene3D G3DSA:1.10.10.10 1 84 4.2E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS24465 0c8c8856c761d6145cc99ac09d8ce161 397 TIGRFAM TIGR02210 rodA_shape: rod shape-determining protein RodA 31 393 2.9E-106 T 09-03-2017 IPR011923 Rod shape-determining protein RodA GO:0008360|GO:0016021 TK78_RS24465 0c8c8856c761d6145cc99ac09d8ce161 397 ProSitePatterns PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. 351 375 - T 09-03-2017 IPR018365 Cell cycle, FtsW / RodA / SpoVE, conserved site GO:0007049|GO:0016021 TK78_RS24465 0c8c8856c761d6145cc99ac09d8ce161 397 Pfam PF01098 Cell cycle protein 34 392 1.4E-94 T 09-03-2017 IPR001182 Cell cycle protein FtsW/RodA GO:0016021|GO:0051301 TK78_RS08900 524ccb426251ba20476510666ac6c2e8 245 SMART SM00644 86 215 1.5E-37 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS08900 524ccb426251ba20476510666ac6c2e8 245 Gene3D G3DSA:3.40.80.10 72 230 4.5E-39 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS08900 524ccb426251ba20476510666ac6c2e8 245 SUPERFAMILY SSF55846 85 229 1.15E-37 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS08900 524ccb426251ba20476510666ac6c2e8 245 Pfam PF01510 N-acetylmuramoyl-L-alanine amidase 96 216 1.9E-20 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS15220 b30a8ddf6f2ae94691c36e754b22a7a2 228 Pfam PF13189 Cytidylate kinase-like family 28 213 8.5E-9 T 09-03-2017 IPR026865 Cytidylate kinase-like family MetaCyc: PWY-7205 TK78_RS15220 b30a8ddf6f2ae94691c36e754b22a7a2 228 SUPERFAMILY SSF52540 19 216 5.68E-22 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15220 b30a8ddf6f2ae94691c36e754b22a7a2 228 Gene3D G3DSA:3.40.50.300 8 216 7.0E-31 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01715 3de4692ac715f8e0c85e202c6105bec7 355 SUPERFAMILY SSF81345 24 350 1.23E-59 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS01715 3de4692ac715f8e0c85e202c6105bec7 355 Pfam PF01032 FecCD transport family 32 350 1.1E-66 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS01715 3de4692ac715f8e0c85e202c6105bec7 355 Gene3D G3DSA:1.10.3470.10 25 353 8.7E-75 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS13370 4e7347e19d135c27c033ea85c01bef03 287 Gene3D G3DSA:3.30.2010.10 59 149 5.8E-31 T 09-03-2017 TK78_RS13370 4e7347e19d135c27c033ea85c01bef03 287 Hamap MF_00188 Protease HtpX [htpX]. 7 282 27.765 T 09-03-2017 IPR022919 Peptidase M48, protease HtpX, putative GO:0004222 TK78_RS13370 4e7347e19d135c27c033ea85c01bef03 287 Pfam PF01435 Peptidase family M48 68 282 9.1E-35 T 09-03-2017 IPR001915 Peptidase M48 GO:0004222|GO:0006508 TK78_RS04250 9f14e9840288726fd8f546538661ea43 287 TIGRFAM TIGR00473 pssA: CDP-diacylglycerol-serine O-phosphatidyltransferase 41 213 1.6E-33 T 09-03-2017 IPR004533 CDP-diacylglycerol--serine O-phosphatidyltransferase KEGG: 00260+2.7.8.8|KEGG: 00564+2.7.8.8|MetaCyc: PWY-5669 TK78_RS04250 9f14e9840288726fd8f546538661ea43 287 Pfam PF01066 CDP-alcohol phosphatidyltransferase 36 115 9.0E-12 T 09-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 TK78_RS04250 9f14e9840288726fd8f546538661ea43 287 ProSitePatterns PS00379 CDP-alcohol phosphatidyltransferases signature. 94 115 - T 09-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 TK78_RS23000 274560ddcba738056e6db1c1be286e76 274 Gene3D G3DSA:3.40.50.10410 88 181 5.8E-33 T 09-03-2017 IPR023215 Nitrophenylphosphatase-like domain TK78_RS23000 274560ddcba738056e6db1c1be286e76 274 Gene3D G3DSA:3.40.50.1000 182 259 2.4E-40 T 09-03-2017 IPR023214 HAD-like domain TK78_RS23000 274560ddcba738056e6db1c1be286e76 274 Gene3D G3DSA:3.40.50.1000 6 83 2.4E-40 T 09-03-2017 IPR023214 HAD-like domain TK78_RS23000 274560ddcba738056e6db1c1be286e76 274 PIRSF PIRSF000915 4 260 5.6E-52 T 09-03-2017 IPR006357 HAD-superfamily hydrolase, subfamily IIA TK78_RS23000 274560ddcba738056e6db1c1be286e76 274 Pfam PF13242 HAD-hyrolase-like 182 255 9.0E-21 T 09-03-2017 TK78_RS23000 274560ddcba738056e6db1c1be286e76 274 TIGRFAM TIGR01460 HAD-SF-IIA: HAD hydrolase, family IIA 11 231 9.3E-47 T 09-03-2017 IPR006357 HAD-superfamily hydrolase, subfamily IIA TK78_RS23000 274560ddcba738056e6db1c1be286e76 274 SUPERFAMILY SSF56784 8 256 6.7E-68 T 09-03-2017 IPR023214 HAD-like domain TK78_RS23000 274560ddcba738056e6db1c1be286e76 274 Pfam PF13344 Haloacid dehalogenase-like hydrolase 10 109 1.9E-26 T 09-03-2017 IPR006357 HAD-superfamily hydrolase, subfamily IIA TK78_RS33320 36c9da7f1b094d13f5db2b436872f5bf 91 SUPERFAMILY SSF47336 2 87 3.27E-13 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33320 36c9da7f1b094d13f5db2b436872f5bf 91 Gene3D G3DSA:1.10.1200.10 4 77 1.5E-13 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS33320 36c9da7f1b094d13f5db2b436872f5bf 91 Pfam PF00550 Phosphopantetheine attachment site 7 72 2.2E-10 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS03975 8f5188a3215fb6b68defd370b896d25e 71 Gene3D G3DSA:1.10.150.20 23 68 2.0E-4 T 09-03-2017 TK78_RS03975 8f5188a3215fb6b68defd370b896d25e 71 SUPERFAMILY SSF47789 20 68 2.49E-5 T 09-03-2017 TK78_RS02290 619c4c9fd023cf20413dd7c596e40b35 501 ProSitePatterns PS00457 Sodium:solute symporter family signature 2. 403 423 - T 09-03-2017 IPR018212 Sodium/solute symporter, conserved site GO:0005215|GO:0006810|GO:0016020 TK78_RS02290 619c4c9fd023cf20413dd7c596e40b35 501 Pfam PF00474 Sodium:solute symporter family 37 421 2.3E-38 T 09-03-2017 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 TK78_RS10230 aac64c21e5bd168c181c4b9136bbb799 533 TIGRFAM TIGR00831 a_cpa1: Na+/H+ antiporter 6 524 5.7E-101 T 09-03-2017 IPR004705 Cation/H+ exchanger, CPA1 family, bacteria GO:0006812|GO:0015299|GO:0016021 TK78_RS10230 aac64c21e5bd168c181c4b9136bbb799 533 Pfam PF00999 Sodium/hydrogen exchanger family 7 403 1.6E-59 T 09-03-2017 IPR006153 Cation/H+ exchanger GO:0006812|GO:0015299|GO:0016021|GO:0055085 TK78_RS04750 a4afe4fd4d3e8c4de2b6ab821af313ea 309 Gene3D G3DSA:3.40.190.10 151 253 2.8E-24 T 09-03-2017 TK78_RS04750 a4afe4fd4d3e8c4de2b6ab821af313ea 309 SMART SM00062 69 293 1.5E-59 T 09-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF TK78_RS04750 a4afe4fd4d3e8c4de2b6ab821af313ea 309 Gene3D G3DSA:3.40.190.10 66 150 1.4E-23 T 09-03-2017 TK78_RS04750 a4afe4fd4d3e8c4de2b6ab821af313ea 309 Gene3D G3DSA:3.40.190.10 254 287 1.4E-23 T 09-03-2017 TK78_RS04750 a4afe4fd4d3e8c4de2b6ab821af313ea 309 SUPERFAMILY SSF53850 59 287 4.04E-53 T 09-03-2017 TK78_RS04750 a4afe4fd4d3e8c4de2b6ab821af313ea 309 SUPERFAMILY SSF53850 14 29 4.04E-53 T 09-03-2017 TK78_RS04750 a4afe4fd4d3e8c4de2b6ab821af313ea 309 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3 70 287 5.0E-46 T 09-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF TK78_RS04750 a4afe4fd4d3e8c4de2b6ab821af313ea 309 ProSitePatterns PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 93 106 - T 09-03-2017 IPR018313 Solute-binding protein family 3, conserved site GO:0005215|GO:0006810 TK78_RS08720 dedef815b54b8a68816fb159564138c7 382 Gene3D G3DSA:1.10.10.60 320 357 1.6E-9 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS08720 dedef815b54b8a68816fb159564138c7 382 SUPERFAMILY SSF46689 319 356 1.43E-5 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS08720 dedef815b54b8a68816fb159564138c7 382 Pfam PF13556 PucR C-terminal helix-turn-helix domain 321 378 1.3E-22 T 09-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain TK78_RS16760 d6da3d26435264f02ac3c4a8c10758ed 550 Pfam PF13193 AMP-binding enzyme C-terminal domain 453 530 1.1E-18 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS16760 d6da3d26435264f02ac3c4a8c10758ed 550 ProSitePatterns PS00455 Putative AMP-binding domain signature. 184 195 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS16760 d6da3d26435264f02ac3c4a8c10758ed 550 Gene3D G3DSA:2.30.38.10 357 438 4.2E-18 T 09-03-2017 TK78_RS16760 d6da3d26435264f02ac3c4a8c10758ed 550 SUPERFAMILY SSF56801 8 542 5.49E-137 T 09-03-2017 TK78_RS16760 d6da3d26435264f02ac3c4a8c10758ed 550 Gene3D G3DSA:3.40.50.980 190 342 1.5E-36 T 09-03-2017 TK78_RS16760 d6da3d26435264f02ac3c4a8c10758ed 550 Gene3D G3DSA:3.40.50.980 21 189 1.3E-29 T 09-03-2017 TK78_RS16760 d6da3d26435264f02ac3c4a8c10758ed 550 Pfam PF00501 AMP-binding enzyme 36 444 5.9E-86 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS16760 d6da3d26435264f02ac3c4a8c10758ed 550 Gene3D G3DSA:3.30.300.30 439 540 3.6E-28 T 09-03-2017 TK78_RS22985 c4d89e4595387685dad4e74bf52371f6 265 SUPERFAMILY SSF161098 7 261 1.06E-44 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS22985 c4d89e4595387685dad4e74bf52371f6 265 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 84 253 1.1E-14 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS22985 c4d89e4595387685dad4e74bf52371f6 265 Gene3D G3DSA:1.10.3720.10 12 263 1.3E-41 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS12670 fdbc8713d0ac9dcc4ef58b6f8aa54ded 543 Gene3D G3DSA:1.10.510.10 123 305 7.6E-48 T 09-03-2017 TK78_RS12670 fdbc8713d0ac9dcc4ef58b6f8aa54ded 543 SUPERFAMILY SSF56112 45 325 2.43E-69 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS12670 fdbc8713d0ac9dcc4ef58b6f8aa54ded 543 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 174 186 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS12670 fdbc8713d0ac9dcc4ef58b6f8aa54ded 543 SMART SM00220 52 312 5.5E-61 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS12670 fdbc8713d0ac9dcc4ef58b6f8aa54ded 543 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 58 81 - T 09-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 TK78_RS12670 fdbc8713d0ac9dcc4ef58b6f8aa54ded 543 Pfam PF00069 Protein kinase domain 52 303 5.9E-46 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS12670 fdbc8713d0ac9dcc4ef58b6f8aa54ded 543 Gene3D G3DSA:3.30.200.20 45 122 4.1E-21 T 09-03-2017 TK78_RS29905 ee7939b7aff7de12626469cb98aa6b1b 288 Pfam PF03180 NLPA lipoprotein 46 282 4.0E-91 T 09-03-2017 IPR004872 Lipoprotein NlpA family TK78_RS29905 ee7939b7aff7de12626469cb98aa6b1b 288 Gene3D G3DSA:3.40.190.10 44 175 5.1E-55 T 09-03-2017 TK78_RS29905 ee7939b7aff7de12626469cb98aa6b1b 288 SUPERFAMILY SSF53850 46 282 5.66E-80 T 09-03-2017 TK78_RS29905 ee7939b7aff7de12626469cb98aa6b1b 288 PIRSF PIRSF002854 1 283 1.3E-103 T 09-03-2017 IPR004872 Lipoprotein NlpA family TK78_RS16335 fafeba461236f92ffec98e3eb15395df 324 TIGRFAM TIGR03718 R_switched_Alx: integral membrane protein, TerC family 4 307 1.2E-116 T 09-03-2017 IPR022369 Integral membrane protein TerC, riboswitch-linked GO:0016021 TK78_RS16335 fafeba461236f92ffec98e3eb15395df 324 Pfam PF03741 Integral membrane protein TerC family 69 271 2.1E-54 T 09-03-2017 IPR005496 Integral membrane protein TerC GO:0016021 TK78_RS29125 5651ba638a1abec626493fe318d6242a 169 PIRSF PIRSF017340 1 169 5.8E-77 T 09-03-2017 IPR024195 NUDIX hydrolase, YfcD, predicted GO:0016817 TK78_RS29125 5651ba638a1abec626493fe318d6242a 169 SUPERFAMILY SSF55811 6 166 2.3E-30 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS29125 5651ba638a1abec626493fe318d6242a 169 Pfam PF00293 NUDIX domain 32 136 5.4E-12 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS29125 5651ba638a1abec626493fe318d6242a 169 Gene3D G3DSA:3.90.79.10 2 165 5.3E-52 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS29125 5651ba638a1abec626493fe318d6242a 169 ProSitePatterns PS00893 Nudix box signature. 69 90 - T 09-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 TK78_RS16510 ad8d6058baa394b05566c61e29fbdef0 98 PIRSF PIRSF006909 1 98 3.7E-58 T 09-03-2017 IPR014447 Uncharacterised conserved protein UCP006909 TK78_RS25455 842699495cfc8d8b9bfb9af1192a7e0d 82 Pfam PF00550 Phosphopantetheine attachment site 12 77 7.2E-16 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS25455 842699495cfc8d8b9bfb9af1192a7e0d 82 ProDom PD000887 CARRIER ACYL PHOSPHOPANTETHEINE ACP ACID FATTY BIOSYNTHESIS LIPID SYNTHESIS CHLOROPLAST 38 80 3.0E-17 T 09-03-2017 IPR003231 Acyl carrier protein (ACP) GO:0006633 Reactome: R-HSA-389661|Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS25455 842699495cfc8d8b9bfb9af1192a7e0d 82 Hamap MF_01217 Acyl carrier protein [acpP]. 7 81 17.032 T 09-03-2017 IPR003231 Acyl carrier protein (ACP) GO:0006633 Reactome: R-HSA-389661|Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS25455 842699495cfc8d8b9bfb9af1192a7e0d 82 SUPERFAMILY SSF47336 2 81 4.71E-22 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS25455 842699495cfc8d8b9bfb9af1192a7e0d 82 Gene3D G3DSA:1.10.1200.10 3 81 6.1E-26 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS24835 64823618181e15486923ec20b91c5404 296 Gene3D G3DSA:1.10.260.40 14 94 7.5E-18 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS24835 64823618181e15486923ec20b91c5404 296 SMART SM00530 16 95 5.5E-7 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS24835 64823618181e15486923ec20b91c5404 296 SUPERFAMILY SSF47413 43 92 6.83E-6 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS24835 64823618181e15486923ec20b91c5404 296 Pfam PF13560 Helix-turn-helix domain 20 98 2.2E-16 T 09-03-2017 TK78_RS29790 a372f2964543d7a622af1b1277c632aa 359 Pfam PF02423 Ornithine cyclodeaminase/mu-crystallin family 36 333 1.0E-30 T 09-03-2017 IPR003462 Ornithine cyclodeaminase/mu-crystallin Reactome: R-HSA-71064 TK78_RS29790 a372f2964543d7a622af1b1277c632aa 359 Gene3D G3DSA:3.30.1780.10 18 159 2.8E-38 T 09-03-2017 IPR023401 Ornithine cyclodeaminase, N-terminal Reactome: R-HSA-71064 TK78_RS29790 a372f2964543d7a622af1b1277c632aa 359 TIGRFAM TIGR03944 dehyd_SbnB_fam: 2,3-diaminopropionate biosynthesis protein SbnB 19 338 4.1E-123 T 09-03-2017 IPR023866 2,3-diaminopropionate biosynthesis protein SbnB TK78_RS29790 a372f2964543d7a622af1b1277c632aa 359 SUPERFAMILY SSF51735 18 341 9.11E-66 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS29790 a372f2964543d7a622af1b1277c632aa 359 PIRSF PIRSF001439 14 342 2.5E-73 T 09-03-2017 IPR003462 Ornithine cyclodeaminase/mu-crystallin Reactome: R-HSA-71064 TK78_RS29790 a372f2964543d7a622af1b1277c632aa 359 Gene3D G3DSA:3.40.50.720 160 312 1.3E-18 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS22615 d0600edf31c91e29e73cc8337842cc55 265 Gene3D G3DSA:3.40.50.300 3 236 3.0E-64 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22615 d0600edf31c91e29e73cc8337842cc55 265 SUPERFAMILY SSF52540 4 226 8.15E-62 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22615 d0600edf31c91e29e73cc8337842cc55 265 Pfam PF00005 ABC transporter 21 169 2.4E-31 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS22615 d0600edf31c91e29e73cc8337842cc55 265 ProSitePatterns PS00211 ABC transporters family signature. 141 155 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS22615 d0600edf31c91e29e73cc8337842cc55 265 SMART SM00382 29 213 1.3E-17 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS12595 874ed4f967e959c935cfcd5acd5e1c3a 359 Gene3D G3DSA:3.90.1720.10 241 358 2.5E-45 T 09-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain TK78_RS12595 874ed4f967e959c935cfcd5acd5e1c3a 359 Pfam PF00877 NlpC/P60 family 259 350 7.4E-27 T 09-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain TK78_RS12595 874ed4f967e959c935cfcd5acd5e1c3a 359 SUPERFAMILY SSF54001 241 358 1.81E-42 T 09-03-2017 TK78_RS07355 ba3ffbe01740a329fea94c47ee97e2c5 656 SUPERFAMILY SSF52540 189 260 5.19E-20 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07355 ba3ffbe01740a329fea94c47ee97e2c5 656 SUPERFAMILY SSF52540 392 406 5.19E-20 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07355 ba3ffbe01740a329fea94c47ee97e2c5 656 SUPERFAMILY SSF52540 36 85 5.19E-20 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07355 ba3ffbe01740a329fea94c47ee97e2c5 656 SUPERFAMILY SSF52540 445 608 5.19E-20 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07355 ba3ffbe01740a329fea94c47ee97e2c5 656 Gene3D G3DSA:3.40.50.300 119 120 2.1E-21 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07355 ba3ffbe01740a329fea94c47ee97e2c5 656 Gene3D G3DSA:3.40.50.300 189 261 2.1E-21 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07355 ba3ffbe01740a329fea94c47ee97e2c5 656 Gene3D G3DSA:3.40.50.300 20 83 2.1E-21 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07355 ba3ffbe01740a329fea94c47ee97e2c5 656 Gene3D G3DSA:3.40.50.300 394 403 2.1E-21 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07355 ba3ffbe01740a329fea94c47ee97e2c5 656 Gene3D G3DSA:3.40.50.300 463 611 1.7E-4 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07355 ba3ffbe01740a329fea94c47ee97e2c5 656 SMART SM00491 488 617 5.2E-42 T 09-03-2017 IPR006555 ATP-dependent helicase, C-terminal GO:0003676|GO:0005524|GO:0006139|GO:0008026|GO:0016818 TK78_RS07355 ba3ffbe01740a329fea94c47ee97e2c5 656 SMART SM00487 17 300 1.9E-6 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS07355 ba3ffbe01740a329fea94c47ee97e2c5 656 Pfam PF13307 Helicase C-terminal domain 471 629 2.8E-27 T 09-03-2017 IPR006555 ATP-dependent helicase, C-terminal GO:0003676|GO:0005524|GO:0006139|GO:0008026|GO:0016818 TK78_RS23845 8bc56fbcf69a6e800d78de4271f1506b 406 PIRSF PIRSF001112 4 401 1.3E-113 T 09-03-2017 IPR016292 Epoxide hydrolase GO:0033961 KEGG: 00980+3.3.2.9|Reactome: R-HSA-211945 TK78_RS23845 8bc56fbcf69a6e800d78de4271f1506b 406 Pfam PF06441 Epoxide hydrolase N terminus 23 134 7.0E-34 T 09-03-2017 IPR010497 Epoxide hydrolase, N-terminal KEGG: 00980+3.3.2.9|Reactome: R-HSA-211945 TK78_RS23845 8bc56fbcf69a6e800d78de4271f1506b 406 SUPERFAMILY SSF53474 13 396 9.99E-98 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS23845 8bc56fbcf69a6e800d78de4271f1506b 406 PRINTS PR00412 Epoxide hydrolase signature 373 395 7.9E-15 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS23845 8bc56fbcf69a6e800d78de4271f1506b 406 PRINTS PR00412 Epoxide hydrolase signature 151 166 7.9E-15 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS23845 8bc56fbcf69a6e800d78de4271f1506b 406 PRINTS PR00412 Epoxide hydrolase signature 125 143 7.9E-15 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS23845 8bc56fbcf69a6e800d78de4271f1506b 406 PRINTS PR00412 Epoxide hydrolase signature 196 209 7.9E-15 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS23845 8bc56fbcf69a6e800d78de4271f1506b 406 PRINTS PR00412 Epoxide hydrolase signature 210 223 7.9E-15 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS23845 8bc56fbcf69a6e800d78de4271f1506b 406 PRINTS PR00412 Epoxide hydrolase signature 341 357 7.9E-15 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS23845 8bc56fbcf69a6e800d78de4271f1506b 406 Gene3D G3DSA:3.40.50.1820 11 402 1.7E-138 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS08305 2819fbb1fca079cb3224a8c58a776bf0 61 Hamap MF_00373 50S ribosomal protein L28 [rpmB]. 1 61 15.888 T 09-03-2017 IPR001383 Ribosomal protein L28 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS08305 2819fbb1fca079cb3224a8c58a776bf0 61 Pfam PF00830 Ribosomal L28 family 4 58 1.6E-23 T 09-03-2017 IPR026569 Ribosomal protein L28/L24 GO:0003735 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS08305 2819fbb1fca079cb3224a8c58a776bf0 61 Gene3D G3DSA:4.10.1160.10 19 61 6.7E-23 T 09-03-2017 IPR001383 Ribosomal protein L28 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS08305 2819fbb1fca079cb3224a8c58a776bf0 61 TIGRFAM TIGR00009 L28: ribosomal protein bL28 2 56 1.3E-22 T 09-03-2017 IPR001383 Ribosomal protein L28 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS08305 2819fbb1fca079cb3224a8c58a776bf0 61 SUPERFAMILY SSF143800 2 59 3.73E-23 T 09-03-2017 TK78_RS06660 bc9a958c5f7fae6ba8f7f835adc59a4b 319 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 116 311 4.7E-33 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS06660 bc9a958c5f7fae6ba8f7f835adc59a4b 319 SUPERFAMILY SSF161098 93 296 3.27E-17 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS06660 bc9a958c5f7fae6ba8f7f835adc59a4b 319 Gene3D G3DSA:1.10.3720.10 92 302 4.5E-17 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS08800 50b8f5c687fa6ff2663a5fcaf30e6bae 396 Pfam PF07995 Glucose / Sorbosone dehydrogenase 77 380 4.1E-70 T 09-03-2017 IPR012938 Glucose/Sorbosone dehydrogenase GO:0005975|GO:0016901|GO:0048038 TK78_RS08800 50b8f5c687fa6ff2663a5fcaf30e6bae 396 SUPERFAMILY SSF50952 68 380 7.32E-44 T 09-03-2017 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 TK78_RS08800 50b8f5c687fa6ff2663a5fcaf30e6bae 396 Gene3D G3DSA:2.120.10.30 62 394 6.9E-85 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS31260 b79a3cdf8050288382f6c694b4fe1250 202 ProSitePatterns PS01063 Sigma-70 factors ECF subfamily signature. 61 92 - T 09-03-2017 IPR000838 RNA polymerase sigma factor 70, ECF, conserved site GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS31260 b79a3cdf8050288382f6c694b4fe1250 202 Pfam PF04542 Sigma-70 region 2 39 104 2.3E-12 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS31260 b79a3cdf8050288382f6c694b4fe1250 202 SUPERFAMILY SSF88659 130 189 3.71E-14 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS31260 b79a3cdf8050288382f6c694b4fe1250 202 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 34 188 4.8E-26 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS31260 b79a3cdf8050288382f6c694b4fe1250 202 SUPERFAMILY SSF88946 19 118 5.49E-21 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS31260 b79a3cdf8050288382f6c694b4fe1250 202 Gene3D G3DSA:1.10.10.10 132 191 6.2E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS31260 b79a3cdf8050288382f6c694b4fe1250 202 Pfam PF08281 Sigma-70, region 4 136 187 1.3E-14 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS31260 b79a3cdf8050288382f6c694b4fe1250 202 Gene3D G3DSA:1.10.1740.10 24 125 8.2E-22 T 09-03-2017 TK78_RS02440 a2338db146d03cddcf18f7b6adfa7311 436 Gene3D G3DSA:3.40.190.10 157 366 4.3E-49 T 09-03-2017 TK78_RS02440 a2338db146d03cddcf18f7b6adfa7311 436 SUPERFAMILY SSF53850 38 433 9.6E-75 T 09-03-2017 TK78_RS02440 a2338db146d03cddcf18f7b6adfa7311 436 Pfam PF01547 Bacterial extracellular solute-binding protein 54 348 2.5E-47 T 09-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 TK78_RS19125 84296b940d042d094c50bf4dab7b365a 526 Pfam PF07681 DoxX 191 292 1.4E-10 T 09-03-2017 IPR032808 DoxX family TK78_RS08965 23232d2db49a10167594807aba3df8d5 256 Pfam PF07179 SseB protein N-terminal domain 20 129 1.8E-13 T 09-03-2017 IPR009839 SseB protein N-terminal domain TK78_RS08965 23232d2db49a10167594807aba3df8d5 256 Pfam PF14581 SseB protein C-terminal domain 143 253 6.0E-25 T 09-03-2017 IPR027945 SseB protein, C-terminal TK78_RS15430 0d6c8c07854912f104f00ddd6aba1ee1 278 SMART SM00849 39 204 3.3E-25 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS15430 0d6c8c07854912f104f00ddd6aba1ee1 278 Pfam PF00753 Metallo-beta-lactamase superfamily 36 204 9.3E-16 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS15430 0d6c8c07854912f104f00ddd6aba1ee1 278 Gene3D G3DSA:3.60.15.10 23 234 2.0E-46 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS15430 0d6c8c07854912f104f00ddd6aba1ee1 278 SUPERFAMILY SSF56281 28 276 1.68E-49 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS26475 6a6891e18825b557f040b0f842a76475 304 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 10 125 2.6E-17 T 09-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 TK78_RS26475 6a6891e18825b557f040b0f842a76475 304 Gene3D G3DSA:3.30.360.10 169 303 6.1E-16 T 09-03-2017 TK78_RS26475 6a6891e18825b557f040b0f842a76475 304 Gene3D G3DSA:3.40.50.720 6 140 2.0E-30 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS26475 6a6891e18825b557f040b0f842a76475 304 SUPERFAMILY SSF55347 152 259 6.38E-11 T 09-03-2017 TK78_RS26475 6a6891e18825b557f040b0f842a76475 304 SUPERFAMILY SSF51735 7 158 5.69E-32 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS30760 f1d69848f10c7150e6742b194cb97e0d 284 Pfam PF05949 Bacterial protein of unknown function (DUF881) 118 259 6.3E-40 T 09-03-2017 IPR010273 Protein of unknown function DUF881 TK78_RS27295 2035dd763383f6b98777ac45ac3eaa98 451 Pfam PF13556 PucR C-terminal helix-turn-helix domain 387 444 1.6E-19 T 09-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain TK78_RS31550 051be850ca408064c4e8ebb1e6c8f4f5 386 Gene3D G3DSA:3.40.640.10 51 264 2.2E-75 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS31550 051be850ca408064c4e8ebb1e6c8f4f5 386 SUPERFAMILY SSF53383 6 375 1.73E-92 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS31550 051be850ca408064c4e8ebb1e6c8f4f5 386 ProSitePatterns PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 228 237 - T 09-03-2017 IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site GO:0008152|GO:0016740 TK78_RS31550 051be850ca408064c4e8ebb1e6c8f4f5 386 Pfam PF00155 Aminotransferase class I and II 33 373 4.9E-57 T 09-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TK78_RS31550 051be850ca408064c4e8ebb1e6c8f4f5 386 Gene3D G3DSA:3.90.1150.10 265 374 1.4E-14 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS05840 c68e4e687535ff97ad2cdcca95d6e4ae 141 SUPERFAMILY SSF82784 1 132 7.07E-31 T 09-03-2017 IPR003718 OsmC/Ohr family TK78_RS05840 c68e4e687535ff97ad2cdcca95d6e4ae 141 Gene3D G3DSA:3.30.300.20 4 140 7.2E-43 T 09-03-2017 IPR015946 K homology domain-like, alpha/beta TK78_RS05840 c68e4e687535ff97ad2cdcca95d6e4ae 141 TIGRFAM TIGR03562 osmo_induc_OsmC: peroxiredoxin, OsmC subfamily 4 138 2.0E-51 T 09-03-2017 IPR019904 Peroxiredoxin OsmC GO:0004601|GO:0006979 KEGG: 00480+1.11.1.15 TK78_RS05840 c68e4e687535ff97ad2cdcca95d6e4ae 141 Pfam PF02566 OsmC-like protein 44 136 1.8E-18 T 09-03-2017 IPR003718 OsmC/Ohr family TK78_RS28105 12631dbce3d9c016da7a946356d0bf3d 483 SUPERFAMILY SSF56601 137 482 3.35E-91 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS28105 12631dbce3d9c016da7a946356d0bf3d 483 Gene3D G3DSA:3.90.1310.10 74 142 1.2E-6 T 09-03-2017 TK78_RS28105 12631dbce3d9c016da7a946356d0bf3d 483 Gene3D G3DSA:3.40.710.10 143 482 1.1E-97 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS28105 12631dbce3d9c016da7a946356d0bf3d 483 Pfam PF00905 Penicillin binding protein transpeptidase domain 154 478 2.6E-68 T 09-03-2017 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 TK78_RS19255 44f4e6bad5fcc18df850fda3de87a66f 443 Pfam PF01565 FAD binding domain 34 170 7.0E-29 T 09-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 TK78_RS19255 44f4e6bad5fcc18df850fda3de87a66f 443 SUPERFAMILY SSF56176 20 201 5.61E-47 T 09-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 TK78_RS19255 44f4e6bad5fcc18df850fda3de87a66f 443 Gene3D G3DSA:3.30.43.10 32 91 1.2E-10 T 09-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 TK78_RS19255 44f4e6bad5fcc18df850fda3de87a66f 443 ProSitePatterns PS00862 Oxygen oxidoreductases covalent FAD-binding site. 34 67 - T 09-03-2017 IPR006093 Oxygen oxidoreductase covalent FAD-binding site GO:0016491|GO:0055114 TK78_RS19255 44f4e6bad5fcc18df850fda3de87a66f 443 Gene3D G3DSA:3.30.465.10 92 201 4.3E-15 T 09-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 TK78_RS16145 28329674296171160ad2e42b2aba97de 222 Pfam PF06197 Protein of unknown function (DUF998) 30 206 2.5E-33 T 09-03-2017 IPR009339 Protein of unknown function DUF998 TK78_RS23885 8ea6fc719c2ff5d342f77a6ea8d6c0ea 432 Pfam PF00285 Citrate synthase, C-terminal domain 49 415 2.0E-135 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS23885 8ea6fc719c2ff5d342f77a6ea8d6c0ea 432 Gene3D G3DSA:1.10.580.10 55 284 1.6E-96 T 09-03-2017 IPR016142 Citrate synthase-like, large alpha subdomain Reactome: R-HSA-1268020|Reactome: R-HSA-71403 TK78_RS23885 8ea6fc719c2ff5d342f77a6ea8d6c0ea 432 ProSitePatterns PS00480 Citrate synthase signature. 307 319 - T 09-03-2017 IPR019810 Citrate synthase active site GO:0006099|GO:0046912 Reactome: R-HSA-1268020|Reactome: R-HSA-71403 TK78_RS23885 8ea6fc719c2ff5d342f77a6ea8d6c0ea 432 TIGRFAM TIGR01798 cit_synth_I: citrate (Si)-synthase 17 426 2.2E-183 T 09-03-2017 IPR010953 Citrate synthase, type I GO:0004108|GO:0005737 TK78_RS23885 8ea6fc719c2ff5d342f77a6ea8d6c0ea 432 PIRSF PIRSF001369 40 432 2.3E-155 T 09-03-2017 IPR024176 Citrate synthase, bacterial-type TK78_RS23885 8ea6fc719c2ff5d342f77a6ea8d6c0ea 432 SUPERFAMILY SSF48256 6 432 4.58E-160 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS23885 8ea6fc719c2ff5d342f77a6ea8d6c0ea 432 PRINTS PR00143 Citrate synthase signature 168 181 8.8E-54 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS23885 8ea6fc719c2ff5d342f77a6ea8d6c0ea 432 PRINTS PR00143 Citrate synthase signature 244 272 8.8E-54 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS23885 8ea6fc719c2ff5d342f77a6ea8d6c0ea 432 PRINTS PR00143 Citrate synthase signature 383 397 8.8E-54 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS23885 8ea6fc719c2ff5d342f77a6ea8d6c0ea 432 PRINTS PR00143 Citrate synthase signature 300 320 8.8E-54 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS23885 8ea6fc719c2ff5d342f77a6ea8d6c0ea 432 PRINTS PR00143 Citrate synthase signature 222 237 8.8E-54 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS23885 8ea6fc719c2ff5d342f77a6ea8d6c0ea 432 PRINTS PR00143 Citrate synthase signature 363 379 8.8E-54 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS23885 8ea6fc719c2ff5d342f77a6ea8d6c0ea 432 Gene3D G3DSA:1.10.230.10 285 377 1.2E-35 T 09-03-2017 IPR016143 Citrate synthase-like, small alpha subdomain Reactome: R-HSA-163765|Reactome: R-HSA-75105 TK78_RS31470 6809baa2569aeb2b4ce67db9d375100f 411 SUPERFAMILY SSF103481 203 286 1.31E-7 T 09-03-2017 TK78_RS31470 6809baa2569aeb2b4ce67db9d375100f 411 SUPERFAMILY SSF103481 41 147 2.75E-10 T 09-03-2017 TK78_RS31470 6809baa2569aeb2b4ce67db9d375100f 411 Pfam PF00892 EamA-like transporter family 154 286 1.1E-7 T 09-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 TK78_RS31470 6809baa2569aeb2b4ce67db9d375100f 411 Pfam PF00892 EamA-like transporter family 7 142 9.2E-12 T 09-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 TK78_RS12425 6263786ba2e64a186aca3ee277f032a2 200 Pfam PF13563 2'-5' RNA ligase superfamily 13 157 7.7E-20 T 09-03-2017 TK78_RS12425 6263786ba2e64a186aca3ee277f032a2 200 Gene3D G3DSA:3.90.1140.10 8 175 1.8E-23 T 09-03-2017 IPR009097 RNA ligase/cyclic nucleotide phosphodiesterase TK78_RS12425 6263786ba2e64a186aca3ee277f032a2 200 SUPERFAMILY SSF55144 5 175 7.32E-29 T 09-03-2017 IPR009097 RNA ligase/cyclic nucleotide phosphodiesterase TK78_RS04990 cae292ec747c0fa2ad90fd8ccd489e75 129 SUPERFAMILY SSF49472 5 129 8.11E-29 T 09-03-2017 IPR023416 Transthyretin/hydroxyisourate hydrolase, superfamily Reactome: R-HSA-2453864|Reactome: R-HSA-2453902|Reactome: R-HSA-3000171|Reactome: R-HSA-975634|Reactome: R-HSA-977225 TK78_RS04990 cae292ec747c0fa2ad90fd8ccd489e75 129 ProSitePatterns PS00768 Transthyretin signature 1. 12 27 - T 09-03-2017 IPR023418 Transthyretin, thyroxine binding site Reactome: R-HSA-2453864|Reactome: R-HSA-2453902|Reactome: R-HSA-3000171|Reactome: R-HSA-975634|Reactome: R-HSA-977225 TK78_RS04990 cae292ec747c0fa2ad90fd8ccd489e75 129 Gene3D G3DSA:2.60.40.180 6 129 1.5E-34 T 09-03-2017 IPR023416 Transthyretin/hydroxyisourate hydrolase, superfamily Reactome: R-HSA-2453864|Reactome: R-HSA-2453902|Reactome: R-HSA-3000171|Reactome: R-HSA-975634|Reactome: R-HSA-977225 TK78_RS04990 cae292ec747c0fa2ad90fd8ccd489e75 129 Pfam PF00576 HIUase/Transthyretin family 9 128 9.2E-35 T 09-03-2017 IPR023416 Transthyretin/hydroxyisourate hydrolase, superfamily Reactome: R-HSA-2453864|Reactome: R-HSA-2453902|Reactome: R-HSA-3000171|Reactome: R-HSA-975634|Reactome: R-HSA-977225 TK78_RS04990 cae292ec747c0fa2ad90fd8ccd489e75 129 TIGRFAM TIGR02962 hdxy_isourate: hydroxyisourate hydrolase 7 129 1.3E-30 T 09-03-2017 IPR014306 Hydroxyisourate hydrolase GO:0006144|GO:0033971 KEGG: 00230+3.5.2.17|MetaCyc: PWY-5691|MetaCyc: PWY-7394 TK78_RS07215 b53d686bacf0af165f123fc2f77feb90 384 PIRSF PIRSF001369 6 383 1.4E-95 T 09-03-2017 IPR024176 Citrate synthase, bacterial-type TK78_RS07215 b53d686bacf0af165f123fc2f77feb90 384 Gene3D G3DSA:1.10.230.10 246 331 1.6E-21 T 09-03-2017 IPR016143 Citrate synthase-like, small alpha subdomain Reactome: R-HSA-163765|Reactome: R-HSA-75105 TK78_RS07215 b53d686bacf0af165f123fc2f77feb90 384 PRINTS PR00143 Citrate synthase signature 136 149 5.8E-33 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS07215 b53d686bacf0af165f123fc2f77feb90 384 PRINTS PR00143 Citrate synthase signature 319 335 5.8E-33 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS07215 b53d686bacf0af165f123fc2f77feb90 384 PRINTS PR00143 Citrate synthase signature 185 200 5.8E-33 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS07215 b53d686bacf0af165f123fc2f77feb90 384 PRINTS PR00143 Citrate synthase signature 207 235 5.8E-33 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS07215 b53d686bacf0af165f123fc2f77feb90 384 PRINTS PR00143 Citrate synthase signature 260 280 5.8E-33 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS07215 b53d686bacf0af165f123fc2f77feb90 384 PRINTS PR00143 Citrate synthase signature 339 353 5.8E-33 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS07215 b53d686bacf0af165f123fc2f77feb90 384 SUPERFAMILY SSF48256 10 381 6.15E-104 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS07215 b53d686bacf0af165f123fc2f77feb90 384 ProSitePatterns PS00480 Citrate synthase signature. 267 279 - T 09-03-2017 IPR019810 Citrate synthase active site GO:0006099|GO:0046912 Reactome: R-HSA-1268020|Reactome: R-HSA-71403 TK78_RS07215 b53d686bacf0af165f123fc2f77feb90 384 Pfam PF00285 Citrate synthase, C-terminal domain 13 369 2.5E-101 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS07215 b53d686bacf0af165f123fc2f77feb90 384 Gene3D G3DSA:1.10.580.10 19 245 1.1E-62 T 09-03-2017 IPR016142 Citrate synthase-like, large alpha subdomain Reactome: R-HSA-1268020|Reactome: R-HSA-71403 TK78_RS14550 b9e3bb4c2fffb7933b6c5459905d5d55 93 Pfam PF17196 Protein of unknown function (DUF5133) 1 64 5.5E-24 T 09-03-2017 IPR033457 Protein of unknown function DUF5133 TK78_RS00785 11e3f6846df64921b702d6fc77ea9cab 166 Gene3D G3DSA:3.40.630.30 2 156 4.8E-37 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS00785 11e3f6846df64921b702d6fc77ea9cab 166 SUPERFAMILY SSF55729 2 150 6.23E-33 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS00785 11e3f6846df64921b702d6fc77ea9cab 166 Pfam PF13302 Acetyltransferase (GNAT) domain 9 145 7.3E-26 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS15975 0c86bf533c0e8738dc79db6ee5526d2b 137 Pfam PF11349 Protein of unknown function (DUF3151) 10 134 2.3E-57 T 09-03-2017 IPR014487 Protein of unknown function DUF3151 TK78_RS15975 0c86bf533c0e8738dc79db6ee5526d2b 137 PIRSF PIRSF017349 1 137 1.3E-64 T 09-03-2017 IPR014487 Protein of unknown function DUF3151 TK78_RS14760 08c6f40b18cf8d37f8c7624baad7d888 229 SUPERFAMILY SSF110395 6 228 1.57E-47 T 09-03-2017 IPR023648 Copper homeostasis CutC domain GO:0005507|GO:0055070 Reactome: R-HSA-936837 TK78_RS14760 08c6f40b18cf8d37f8c7624baad7d888 229 Pfam PF03932 CutC family 7 194 3.0E-26 T 09-03-2017 IPR005627 Copper homeostasis protein CutC GO:0005507|GO:0055070 Reactome: R-HSA-936837 TK78_RS14760 08c6f40b18cf8d37f8c7624baad7d888 229 Gene3D G3DSA:3.20.20.380 5 228 1.0E-51 T 09-03-2017 IPR023648 Copper homeostasis CutC domain GO:0005507|GO:0055070 Reactome: R-HSA-936837 TK78_RS12170 5a277901135b36b32695acd076671d31 137 Pfam PF08211 Cytidine and deoxycytidylate deaminase zinc-binding region 15 65 7.7E-10 T 09-03-2017 IPR013171 Cytidine/deoxycytidylate deaminase, zinc-binding domain GO:0004126|GO:0008270|GO:0009972 KEGG: 00240+3.5.4.5|KEGG: 00983+3.5.4.5|MetaCyc: PWY-6556|MetaCyc: PWY-7181|MetaCyc: PWY-7193|MetaCyc: PWY-7199 TK78_RS12170 5a277901135b36b32695acd076671d31 137 SUPERFAMILY SSF53927 13 136 7.72E-40 T 09-03-2017 IPR016193 Cytidine deaminase-like GO:0003824 TK78_RS12170 5a277901135b36b32695acd076671d31 137 TIGRFAM TIGR01354 cyt_deam_tetra: cytidine deaminase 16 136 1.0E-33 T 09-03-2017 IPR006262 Cytidine deaminase, homotetrameric GO:0004126|GO:0008270|GO:0009972 KEGG: 00240+3.5.4.5|KEGG: 00983+3.5.4.5|MetaCyc: PWY-6556|MetaCyc: PWY-7181|MetaCyc: PWY-7193|MetaCyc: PWY-7199|Reactome: R-HSA-73614 TK78_RS12170 5a277901135b36b32695acd076671d31 137 Gene3D G3DSA:3.40.140.10 9 137 9.0E-43 T 09-03-2017 TK78_RS26805 db19b7d3c9f993ec31c0394f11527f8d 459 Gene3D G3DSA:3.40.640.10 54 292 1.9E-64 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS26805 db19b7d3c9f993ec31c0394f11527f8d 459 Gene3D G3DSA:3.90.1150.10 293 376 1.8E-15 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS26805 db19b7d3c9f993ec31c0394f11527f8d 459 Gene3D G3DSA:3.90.1150.10 408 432 1.8E-15 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS26805 db19b7d3c9f993ec31c0394f11527f8d 459 Pfam PF00266 Aminotransferase class-V 38 426 4.1E-73 T 09-03-2017 IPR000192 Aminotransferase class V domain TK78_RS26805 db19b7d3c9f993ec31c0394f11527f8d 459 SUPERFAMILY SSF53383 35 436 5.24E-83 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS19945 6a3e134ee1d257e935059c2490113489 214 TIGRFAM TIGR01549 HAD-SF-IA-v1: HAD hydrolase, family IA, variant 1 74 181 1.7E-6 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS19945 6a3e134ee1d257e935059c2490113489 214 SUPERFAMILY SSF56784 2 213 1.82E-50 T 09-03-2017 IPR023214 HAD-like domain TK78_RS19945 6a3e134ee1d257e935059c2490113489 214 Pfam PF13419 Haloacid dehalogenase-like hydrolase 6 185 7.4E-26 T 09-03-2017 IPR023214 HAD-like domain TK78_RS19945 6a3e134ee1d257e935059c2490113489 214 Gene3D G3DSA:3.40.50.1000 1 17 4.9E-41 T 09-03-2017 IPR023214 HAD-like domain TK78_RS19945 6a3e134ee1d257e935059c2490113489 214 Gene3D G3DSA:3.40.50.1000 89 213 4.9E-41 T 09-03-2017 IPR023214 HAD-like domain TK78_RS19945 6a3e134ee1d257e935059c2490113489 214 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 55 186 1.2E-17 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS19945 6a3e134ee1d257e935059c2490113489 214 Gene3D G3DSA:1.10.150.240 18 84 1.6E-12 T 09-03-2017 IPR023198 Phosphoglycolate phosphatase, domain 2 TK78_RS32935 4596a45e23e326418cb9f5c4daaa0793 308 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 127 298 2.5E-14 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS32935 4596a45e23e326418cb9f5c4daaa0793 308 SUPERFAMILY SSF161098 33 308 2.07E-51 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS32935 4596a45e23e326418cb9f5c4daaa0793 308 Gene3D G3DSA:1.10.3720.10 30 296 1.2E-47 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS11370 5638259f5214528b89ebdc3beeeddd9a 196 Gene3D G3DSA:3.40.109.10 13 194 1.1E-38 T 09-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TK78_RS11370 5638259f5214528b89ebdc3beeeddd9a 196 SUPERFAMILY SSF55469 14 195 9.42E-40 T 09-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TK78_RS11370 5638259f5214528b89ebdc3beeeddd9a 196 Pfam PF00881 Nitroreductase family 15 174 7.9E-16 T 09-03-2017 IPR029479 Nitroreductase Reactome: R-HSA-209968 TK78_RS11370 5638259f5214528b89ebdc3beeeddd9a 196 Hamap MF_01204 Probable malonic semialdehyde reductase RutE [rutE]. 2 196 40.494 T 09-03-2017 IPR023936 NADH dehydrogenase/NAD(P)H nitroreductase, putative, RutE GO:0016491|GO:0055114 TK78_RS07245 ab5299bda5f5201abe7c6fe2e67b5f0c 147 Pfam PF04341 Protein of unknown function, DUF485 50 135 2.9E-26 T 09-03-2017 IPR007436 Protein of unknown function DUF485 TK78_RS03220 93e0954061c6bd4d7e182c3c254ab4bc 207 Pfam PF03729 Short repeat of unknown function (DUF308) 76 145 8.4E-7 T 09-03-2017 IPR005325 Protein of unknown function DUF308, membrane TK78_RS03220 93e0954061c6bd4d7e182c3c254ab4bc 207 Pfam PF03729 Short repeat of unknown function (DUF308) 20 89 3.1E-11 T 09-03-2017 IPR005325 Protein of unknown function DUF308, membrane TK78_RS34170 abde2e7c60009b82ff536985490e4683 226 Pfam PF01464 Transglycosylase SLT domain 151 221 7.6E-11 T 09-03-2017 IPR008258 Transglycosylase SLT domain 1 TK78_RS34170 abde2e7c60009b82ff536985490e4683 226 Gene3D G3DSA:1.10.530.10 147 222 1.5E-10 T 09-03-2017 TK78_RS34170 abde2e7c60009b82ff536985490e4683 226 SUPERFAMILY SSF53955 133 221 1.88E-15 T 09-03-2017 IPR023346 Lysozyme-like domain TK78_RS27755 70cdcb73b07ebf3e9f6075a262d5e3a5 303 ProSitePatterns PS00584 pfkB family of carbohydrate kinases signature 2. 256 269 - T 09-03-2017 IPR002173 Carbohydrate/puine kinase, PfkB, conserved site GO:0016773 TK78_RS27755 70cdcb73b07ebf3e9f6075a262d5e3a5 303 Pfam PF00294 pfkB family carbohydrate kinase 10 300 8.4E-45 T 09-03-2017 IPR011611 Carbohydrate kinase PfkB TK78_RS27755 70cdcb73b07ebf3e9f6075a262d5e3a5 303 SUPERFAMILY SSF53613 10 301 3.27E-57 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS27755 70cdcb73b07ebf3e9f6075a262d5e3a5 303 Gene3D G3DSA:3.40.1190.20 10 300 4.5E-58 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS10255 1c5024e3197f0881d7c32b8d69c18a52 322 SMART SM00046 2 133 2.3E-10 T 09-03-2017 IPR001206 Diacylglycerol kinase, catalytic domain GO:0016301 TK78_RS10255 1c5024e3197f0881d7c32b8d69c18a52 322 Pfam PF00781 Diacylglycerol kinase catalytic domain 2 120 8.1E-27 T 09-03-2017 IPR001206 Diacylglycerol kinase, catalytic domain GO:0016301 TK78_RS10255 1c5024e3197f0881d7c32b8d69c18a52 322 Gene3D G3DSA:3.40.50.10330 5 81 1.9E-5 T 09-03-2017 IPR017438 Inorganic polyphosphate/ATP-NAD kinase, domain 1 GO:0003951|GO:0008152 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 TK78_RS10255 1c5024e3197f0881d7c32b8d69c18a52 322 SUPERFAMILY SSF111331 1 322 8.37E-52 T 09-03-2017 IPR016064 NAD kinase/diacylglycerol kinase-like domain TK78_RS03025 2dfa56698cbf43b0ebbef539b0a64946 309 SUPERFAMILY SSF51735 6 246 6.58E-47 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS03025 2dfa56698cbf43b0ebbef539b0a64946 309 Pfam PF00106 short chain dehydrogenase 16 216 6.5E-24 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS03025 2dfa56698cbf43b0ebbef539b0a64946 309 Gene3D G3DSA:3.40.50.720 6 234 8.6E-52 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS03025 2dfa56698cbf43b0ebbef539b0a64946 309 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 144 152 1.8E-5 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS03025 2dfa56698cbf43b0ebbef539b0a64946 309 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 93 104 1.8E-5 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS03025 2dfa56698cbf43b0ebbef539b0a64946 309 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 176 195 1.8E-5 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS03025 2dfa56698cbf43b0ebbef539b0a64946 309 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 93 104 2.4E-9 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS03025 2dfa56698cbf43b0ebbef539b0a64946 309 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 16 33 2.4E-9 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS32150 716a36b8d1fef963551c94d76c67ade1 352 Pfam PF01032 FecCD transport family 37 345 2.0E-80 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS32150 716a36b8d1fef963551c94d76c67ade1 352 Gene3D G3DSA:1.10.3470.10 25 348 4.6E-84 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS32150 716a36b8d1fef963551c94d76c67ade1 352 SUPERFAMILY SSF81345 22 345 1.2E-68 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS21275 7381fe9af07876bd70e82634018e7452 556 Pfam PF00474 Sodium:solute symporter family 44 453 2.8E-49 T 09-03-2017 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 TK78_RS21275 7381fe9af07876bd70e82634018e7452 556 TIGRFAM TIGR00813 sss: transporter, solute:sodium symporter (SSS) family 44 453 9.5E-69 T 09-03-2017 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 TK78_RS16715 1deefbb73a711a7abc85b9216a03eefb 156 Pfam PF00293 NUDIX domain 19 139 9.8E-19 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS16715 1deefbb73a711a7abc85b9216a03eefb 156 Gene3D G3DSA:3.90.79.10 7 148 1.9E-36 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS16715 1deefbb73a711a7abc85b9216a03eefb 156 SUPERFAMILY SSF55811 10 150 2.03E-33 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS20940 a4434993a83abbd529075a1e21282ffb 266 Pfam PF02274 Amidinotransferase 26 159 7.7E-9 T 09-03-2017 TK78_RS20940 a4434993a83abbd529075a1e21282ffb 266 Gene3D G3DSA:3.75.10.10 1 265 7.6E-57 T 09-03-2017 TK78_RS20940 a4434993a83abbd529075a1e21282ffb 266 SUPERFAMILY SSF55909 1 266 1.53E-49 T 09-03-2017 TK78_RS29655 7736e8475de184753c3217f1d238b7d0 563 TIGRFAM TIGR04141 TIGR04141: sporadically distributed protein, TIGR04141 family 51 561 1.3E-88 T 09-03-2017 IPR026487 Sporadically distributed protein CHP04141 TK78_RS00395 b3bc0c3a8056e95339dbc9a4c543af6b 41 Gene3D G3DSA:1.10.10.10 1 41 8.0E-8 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS00395 b3bc0c3a8056e95339dbc9a4c543af6b 41 SUPERFAMILY SSF46894 1 41 2.93E-7 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS19235 03a5e8e632817f08fc41f1de207d07bd 853 Pfam PF00975 Thioesterase domain 618 717 1.2E-13 T 09-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 TK78_RS19235 03a5e8e632817f08fc41f1de207d07bd 853 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 52 450 1.3E-109 T 09-03-2017 IPR010071 Amino acid adenylation domain TK78_RS19235 03a5e8e632817f08fc41f1de207d07bd 853 Gene3D G3DSA:1.10.1200.10 534 597 2.2E-17 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS19235 03a5e8e632817f08fc41f1de207d07bd 853 ProSitePatterns PS00455 Putative AMP-binding domain signature. 168 179 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS19235 03a5e8e632817f08fc41f1de207d07bd 853 Gene3D G3DSA:3.40.50.980 179 327 1.4E-40 T 09-03-2017 TK78_RS19235 03a5e8e632817f08fc41f1de207d07bd 853 SUPERFAMILY SSF56801 21 544 6.8E-136 T 09-03-2017 TK78_RS19235 03a5e8e632817f08fc41f1de207d07bd 853 Gene3D G3DSA:2.30.38.10 337 416 2.9E-20 T 09-03-2017 TK78_RS19235 03a5e8e632817f08fc41f1de207d07bd 853 SUPERFAMILY SSF53474 560 844 1.68E-20 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS19235 03a5e8e632817f08fc41f1de207d07bd 853 Pfam PF00550 Phosphopantetheine attachment site 533 593 9.6E-10 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS19235 03a5e8e632817f08fc41f1de207d07bd 853 Gene3D G3DSA:3.40.50.980 25 178 5.8E-42 T 09-03-2017 TK78_RS19235 03a5e8e632817f08fc41f1de207d07bd 853 Gene3D G3DSA:3.30.300.30 421 533 1.0E-28 T 09-03-2017 TK78_RS19235 03a5e8e632817f08fc41f1de207d07bd 853 Pfam PF13193 AMP-binding enzyme C-terminal domain 434 504 6.4E-6 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS19235 03a5e8e632817f08fc41f1de207d07bd 853 Pfam PF00501 AMP-binding enzyme 31 425 1.2E-83 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS19235 03a5e8e632817f08fc41f1de207d07bd 853 Gene3D G3DSA:3.40.50.1820 611 718 5.0E-15 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS13120 98124afe5d60525fff598f8e00fd3986 94 SUPERFAMILY SSF50249 16 93 4.03E-30 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS13120 98124afe5d60525fff598f8e00fd3986 94 ProDom PD001295 RIBOSOMAL S17 30S RIBONUCLEOPROTEIN RRNA-BINDING RNA-BINDING 40S S11 S17P S11 16 87 2.0E-31 T 09-03-2017 IPR000266 Ribosomal protein S17/S11 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13120 98124afe5d60525fff598f8e00fd3986 94 PRINTS PR00973 Ribosomal protein S17 family signature 35 58 3.0E-11 T 09-03-2017 IPR000266 Ribosomal protein S17/S11 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13120 98124afe5d60525fff598f8e00fd3986 94 PRINTS PR00973 Ribosomal protein S17 family signature 77 84 3.0E-11 T 09-03-2017 IPR000266 Ribosomal protein S17/S11 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13120 98124afe5d60525fff598f8e00fd3986 94 PRINTS PR00973 Ribosomal protein S17 family signature 67 77 3.0E-11 T 09-03-2017 IPR000266 Ribosomal protein S17/S11 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13120 98124afe5d60525fff598f8e00fd3986 94 Hamap MF_01345_B 30S ribosomal protein S17 [rpsQ]. 14 92 25.232 T 09-03-2017 IPR000266 Ribosomal protein S17/S11 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13120 98124afe5d60525fff598f8e00fd3986 94 Pfam PF00366 Ribosomal protein S17 21 88 1.2E-30 T 09-03-2017 IPR000266 Ribosomal protein S17/S11 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13120 98124afe5d60525fff598f8e00fd3986 94 TIGRFAM TIGR03635 uS17_bact: ribosomal protein uS17 16 87 7.0E-35 T 09-03-2017 IPR019984 Ribosomal protein S17, bacterial-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS13120 98124afe5d60525fff598f8e00fd3986 94 Gene3D G3DSA:2.40.50.140 16 93 2.2E-34 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS13120 98124afe5d60525fff598f8e00fd3986 94 ProSitePatterns PS00056 Ribosomal protein S17 signature. 67 79 - T 09-03-2017 IPR019979 Ribosomal protein S17, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS00610 25484d4d358d341229137241e0703dfe 392 Gene3D G3DSA:3.60.10.10 157 331 4.2E-6 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS00610 25484d4d358d341229137241e0703dfe 392 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 166 383 8.6E-18 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS00610 25484d4d358d341229137241e0703dfe 392 SUPERFAMILY SSF56219 161 391 2.49E-26 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS07640 4247f46c1c95bce61bab58a7fb37449a 299 Pfam PF00701 Dihydrodipicolinate synthetase family 11 292 8.5E-84 T 09-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 TK78_RS07640 4247f46c1c95bce61bab58a7fb37449a 299 Gene3D G3DSA:3.20.20.70 9 294 5.2E-107 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS07640 4247f46c1c95bce61bab58a7fb37449a 299 PRINTS PR00146 Dihydrodipicolinate synthase signature 44 65 4.8E-32 T 09-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 TK78_RS07640 4247f46c1c95bce61bab58a7fb37449a 299 PRINTS PR00146 Dihydrodipicolinate synthase signature 112 128 4.8E-32 T 09-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 TK78_RS07640 4247f46c1c95bce61bab58a7fb37449a 299 PRINTS PR00146 Dihydrodipicolinate synthase signature 137 154 4.8E-32 T 09-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 TK78_RS07640 4247f46c1c95bce61bab58a7fb37449a 299 PRINTS PR00146 Dihydrodipicolinate synthase signature 80 98 4.8E-32 T 09-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 TK78_RS07640 4247f46c1c95bce61bab58a7fb37449a 299 TIGRFAM TIGR00674 dapA: 4-hydroxy-tetrahydrodipicolinate synthase 14 289 7.2E-86 T 09-03-2017 IPR005263 4-hydroxy-tetrahydrodipicolinate synthase, DapA GO:0008840|GO:0009089 KEGG: 00261+4.3.3.7|KEGG: 00300+4.3.3.7|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS07640 4247f46c1c95bce61bab58a7fb37449a 299 PIRSF PIRSF001365 7 298 5.7E-80 T 09-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 TK78_RS07640 4247f46c1c95bce61bab58a7fb37449a 299 SMART SM01130 10 295 7.6E-121 T 09-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 TK78_RS07640 4247f46c1c95bce61bab58a7fb37449a 299 ProSitePatterns PS00666 Dihydrodipicolinate synthase signature 2. 142 172 - T 09-03-2017 IPR020625 Schiff base-forming aldolase, active site GO:0008152|GO:0016829 KEGG: 00261+4.3.3.7|KEGG: 00300+4.3.3.7|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS07640 4247f46c1c95bce61bab58a7fb37449a 299 SUPERFAMILY SSF51569 7 289 2.09E-95 T 09-03-2017 TK78_RS07640 4247f46c1c95bce61bab58a7fb37449a 299 Hamap MF_00418 4-hydroxy-tetrahydrodipicolinate synthase [dapA]. 10 294 57.557 T 09-03-2017 IPR005263 4-hydroxy-tetrahydrodipicolinate synthase, DapA GO:0008840|GO:0009089 KEGG: 00261+4.3.3.7|KEGG: 00300+4.3.3.7|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS07640 4247f46c1c95bce61bab58a7fb37449a 299 ProSitePatterns PS00665 Dihydrodipicolinate synthase signature 1. 47 64 - T 09-03-2017 IPR020624 Schiff base-forming aldolase, conserved site GO:0008152|GO:0016829 KEGG: 00261+4.3.3.7|KEGG: 00300+4.3.3.7|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS06215 481ae0b8dd22dd2173146ee2f4225e0d 242 SUPERFAMILY SSF52540 2 227 8.7E-54 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06215 481ae0b8dd22dd2173146ee2f4225e0d 242 Pfam PF00005 ABC transporter 17 165 6.9E-31 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS06215 481ae0b8dd22dd2173146ee2f4225e0d 242 ProSitePatterns PS00211 ABC transporters family signature. 138 152 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS06215 481ae0b8dd22dd2173146ee2f4225e0d 242 Gene3D G3DSA:3.40.50.300 1 226 2.7E-54 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06215 481ae0b8dd22dd2173146ee2f4225e0d 242 SMART SM00382 26 214 1.3E-9 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS16000 db9d86a45549fcea886346625d6e754a 268 SUPERFAMILY SSF74650 11 246 1.38E-36 T 09-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 TK78_RS16000 db9d86a45549fcea886346625d6e754a 268 Pfam PF01263 Aldose 1-epimerase 23 191 4.6E-16 T 09-03-2017 IPR008183 Aldose 1-/Glucose-6-phosphate 1-epimerase GO:0005975|GO:0016853 TK78_RS16000 db9d86a45549fcea886346625d6e754a 268 Gene3D G3DSA:2.70.98.10 40 245 3.2E-12 T 09-03-2017 IPR014718 Glycoside hydrolase-type carbohydrate-binding GO:0003824|GO:0005975|GO:0030246 TK78_RS07375 ef67e4522e9ea63d80de8d96bbcd5cb9 464 Gene3D G3DSA:3.40.640.10 72 316 1.6E-66 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS07375 ef67e4522e9ea63d80de8d96bbcd5cb9 464 Gene3D G3DSA:3.90.1150.10 317 449 9.3E-54 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS07375 ef67e4522e9ea63d80de8d96bbcd5cb9 464 SUPERFAMILY SSF53383 27 447 9.26E-112 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS07375 ef67e4522e9ea63d80de8d96bbcd5cb9 464 TIGRFAM TIGR00709 dat: 2,4-diaminobutyrate 4-transaminase 19 452 3.4E-144 T 09-03-2017 IPR004637 2,4-diaminobutyrate 4-transaminase GO:0008483|GO:0009058 KEGG: 00260+2.6.1.76|MetaCyc: PWY-6409|MetaCyc: PWY-6562|MetaCyc: PWY-761 TK78_RS07375 ef67e4522e9ea63d80de8d96bbcd5cb9 464 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 251 288 - T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS07375 ef67e4522e9ea63d80de8d96bbcd5cb9 464 Pfam PF00202 Aminotransferase class-III 36 447 5.8E-86 T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS13555 42ba74f8a7204b3b73a267c87f87b8a5 499 ProSitePatterns PS01022 PTR2 family proton/oligopeptide symporters signature 1. 87 111 - T 09-03-2017 IPR018456 PTR2 family proton/oligopeptide symporter, conserved site GO:0005215|GO:0006857|GO:0016020 Reactome: R-HSA-427975 TK78_RS13555 42ba74f8a7204b3b73a267c87f87b8a5 499 Pfam PF00854 POT family 98 466 3.4E-60 T 09-03-2017 IPR000109 Proton-dependent oligopeptide transporter family GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-427975 TK78_RS13555 42ba74f8a7204b3b73a267c87f87b8a5 499 TIGRFAM TIGR00924 yjdL_sub1_fam: amino acid/peptide transporter (Peptide:H+ symporter) 19 495 3.5E-113 T 09-03-2017 IPR005279 Dipeptide/tripeptide permease GO:0015197|GO:0015833|GO:0016020 TK78_RS13555 42ba74f8a7204b3b73a267c87f87b8a5 499 SUPERFAMILY SSF103473 286 493 2.35E-30 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS13555 42ba74f8a7204b3b73a267c87f87b8a5 499 SUPERFAMILY SSF103473 10 217 2.35E-30 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS13555 42ba74f8a7204b3b73a267c87f87b8a5 499 Gene3D G3DSA:1.20.1250.20 292 489 2.3E-6 T 09-03-2017 TK78_RS13555 42ba74f8a7204b3b73a267c87f87b8a5 499 Gene3D G3DSA:1.20.1250.20 40 211 2.6E-15 T 09-03-2017 TK78_RS13555 42ba74f8a7204b3b73a267c87f87b8a5 499 ProSitePatterns PS01023 PTR2 family proton/oligopeptide symporters signature 2. 160 172 - T 09-03-2017 IPR018456 PTR2 family proton/oligopeptide symporter, conserved site GO:0005215|GO:0006857|GO:0016020 Reactome: R-HSA-427975 TK78_RS25745 c3b8e128095b1b88c9ae111edeabc506 220 Pfam PF13419 Haloacid dehalogenase-like hydrolase 12 184 3.7E-17 T 09-03-2017 IPR023214 HAD-like domain TK78_RS25745 c3b8e128095b1b88c9ae111edeabc506 220 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 116 184 1.2E-15 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS25745 c3b8e128095b1b88c9ae111edeabc506 220 Gene3D G3DSA:3.40.50.1000 79 209 2.7E-34 T 09-03-2017 IPR023214 HAD-like domain TK78_RS25745 c3b8e128095b1b88c9ae111edeabc506 220 Gene3D G3DSA:1.10.150.240 25 67 2.3E-6 T 09-03-2017 IPR023198 Phosphoglycolate phosphatase, domain 2 TK78_RS25745 c3b8e128095b1b88c9ae111edeabc506 220 ProSitePatterns PS01228 Hypothetical cof family signature 1. 10 21 - T 09-03-2017 IPR000150 Cof protein GO:0016787 TK78_RS25745 c3b8e128095b1b88c9ae111edeabc506 220 SUPERFAMILY SSF56784 10 203 2.21E-36 T 09-03-2017 IPR023214 HAD-like domain TK78_RS16125 9fa5f4151ef6c9488261e1345463c730 191 Hamap MF_00146 Deoxycytidine triphosphate deaminase [dcd]. 1 182 33.936 T 09-03-2017 IPR011962 Deoxycytidine triphosphate deaminase GO:0006229|GO:0008829 KEGG: 00240+3.5.4.13|MetaCyc: PWY-7187 TK78_RS16125 9fa5f4151ef6c9488261e1345463c730 191 Gene3D G3DSA:2.70.40.10 2 184 2.9E-66 T 09-03-2017 IPR029054 dUTPase-like TK78_RS16125 9fa5f4151ef6c9488261e1345463c730 191 SUPERFAMILY SSF51283 2 184 5.5E-57 T 09-03-2017 IPR029054 dUTPase-like TK78_RS16125 9fa5f4151ef6c9488261e1345463c730 191 TIGRFAM TIGR02274 dCTP_deam: deoxycytidine triphosphate deaminase 3 181 1.4E-63 T 09-03-2017 IPR011962 Deoxycytidine triphosphate deaminase GO:0006229|GO:0008829 KEGG: 00240+3.5.4.13|MetaCyc: PWY-7187 TK78_RS16125 9fa5f4151ef6c9488261e1345463c730 191 Pfam PF00692 dUTPase 70 180 2.7E-10 T 09-03-2017 IPR008180 Deoxyuridine triphosphate nucleotidohydrolase/Deoxycytidine triphosphate deaminase GO:0016787|GO:0046080 TK78_RS12455 c76c329a53b62a35bcf1ae2571962a11 171 SUPERFAMILY SSF69118 19 161 3.19E-40 T 09-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 TK78_RS12455 c76c329a53b62a35bcf1ae2571962a11 171 Pfam PF02627 Carboxymuconolactone decarboxylase family 29 110 1.1E-19 T 09-03-2017 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 TK78_RS12455 c76c329a53b62a35bcf1ae2571962a11 171 TIGRFAM TIGR00778 ahpD_dom: alkylhydroperoxidase AhpD family core domain 45 94 3.3E-20 T 09-03-2017 IPR004675 Alkylhydroperoxidase AhpD core GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 TK78_RS12455 c76c329a53b62a35bcf1ae2571962a11 171 Gene3D G3DSA:1.20.1290.10 19 164 4.5E-49 T 09-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 TK78_RS28575 6b9b5d4c826622c5613bc08eaec64e99 266 SUPERFAMILY SSF52540 4 229 2.77E-59 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28575 6b9b5d4c826622c5613bc08eaec64e99 266 Gene3D G3DSA:3.40.50.300 3 238 1.4E-62 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28575 6b9b5d4c826622c5613bc08eaec64e99 266 Pfam PF00005 ABC transporter 20 167 3.6E-30 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS28575 6b9b5d4c826622c5613bc08eaec64e99 266 SMART SM00382 28 217 2.4E-15 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS28575 6b9b5d4c826622c5613bc08eaec64e99 266 ProSitePatterns PS00211 ABC transporters family signature. 140 154 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS34215 83af61ebf28534eb8eab0a98d6865eb6 263 Pfam PF14333 Domain of unknown function (DUF4389) 32 105 3.4E-18 T 09-03-2017 IPR025498 Protein of unknown function DUF4389 TK78_RS34215 83af61ebf28534eb8eab0a98d6865eb6 263 Pfam PF14333 Domain of unknown function (DUF4389) 126 199 2.5E-20 T 09-03-2017 IPR025498 Protein of unknown function DUF4389 TK78_RS31715 59d148ff4cbf7352ce154c70ffac2b8b 321 Pfam PF04087 Domain of unknown function (DUF389) 147 290 1.5E-24 T 09-03-2017 IPR005240 Protein of unknown function DUF389 TK78_RS00585 a9536faf6b1f8ef6eb76fe9a1fb7a86c 340 Gene3D G3DSA:3.40.50.1980 59 201 6.0E-11 T 09-03-2017 TK78_RS00585 a9536faf6b1f8ef6eb76fe9a1fb7a86c 340 SUPERFAMILY SSF53807 59 335 7.46E-41 T 09-03-2017 TK78_RS00585 a9536faf6b1f8ef6eb76fe9a1fb7a86c 340 Gene3D G3DSA:3.40.50.1980 204 335 1.8E-25 T 09-03-2017 TK78_RS00585 a9536faf6b1f8ef6eb76fe9a1fb7a86c 340 Pfam PF01497 Periplasmic binding protein 62 314 2.8E-26 T 09-03-2017 IPR002491 ABC transporter periplasmic binding domain GO:0005488 TK78_RS32725 be5031083dfb8d77326639ab0bcc618d 432 SUPERFAMILY SSF51621 98 344 1.36E-13 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS32725 be5031083dfb8d77326639ab0bcc618d 432 Pfam PF03328 HpcH/HpaI aldolase/citrate lyase family 187 296 9.9E-7 T 09-03-2017 IPR005000 HpcH/HpaI aldolase/citrate lyase domain GO:0003824 TK78_RS32725 be5031083dfb8d77326639ab0bcc618d 432 Gene3D G3DSA:3.20.20.60 104 303 9.5E-14 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS01205 aca215cb455256f9e65201ed8203dc47 294 Gene3D G3DSA:1.10.3720.10 19 280 3.4E-47 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS01205 aca215cb455256f9e65201ed8203dc47 294 SUPERFAMILY SSF161098 20 294 2.22E-53 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS01205 aca215cb455256f9e65201ed8203dc47 294 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 107 277 5.1E-13 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS23725 bfb07b84bb951bd51cfa3242efab73e2 209 Pfam PF13185 GAF domain 26 164 1.1E-18 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS23725 bfb07b84bb951bd51cfa3242efab73e2 209 SMART SM00065 25 174 3.9E-22 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS23725 bfb07b84bb951bd51cfa3242efab73e2 209 Gene3D G3DSA:3.30.450.40 28 178 1.1E-32 T 09-03-2017 IPR029016 GAF domain-like TK78_RS23725 bfb07b84bb951bd51cfa3242efab73e2 209 SUPERFAMILY SSF55781 27 165 2.62E-30 T 09-03-2017 IPR029016 GAF domain-like TK78_RS02550 a31b4e8beae4c960950e8cdf39a9de0d 256 Pfam PF02585 GlcNAc-PI de-N-acetylase 7 132 7.4E-20 T 09-03-2017 IPR003737 N-acetylglucosaminyl phosphatidylinositol deacetylase-related Reactome: R-HSA-162710 TK78_RS02550 a31b4e8beae4c960950e8cdf39a9de0d 256 SUPERFAMILY SSF102588 5 241 9.55E-50 T 09-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 TK78_RS02550 a31b4e8beae4c960950e8cdf39a9de0d 256 Gene3D G3DSA:3.40.50.10320 5 243 4.5E-55 T 09-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 TK78_RS25140 417290d2a3c9f61ae5d11bb52ba36161 277 Gene3D G3DSA:1.10.3720.10 2 249 3.1E-28 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS25140 417290d2a3c9f61ae5d11bb52ba36161 277 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 69 248 9.1E-9 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS25140 417290d2a3c9f61ae5d11bb52ba36161 277 SUPERFAMILY SSF161098 2 247 7.98E-30 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS03085 df33831f635059247ef5e6dd964f7384 385 SUPERFAMILY SSF56059 134 198 4.71E-9 T 09-03-2017 TK78_RS03085 df33831f635059247ef5e6dd964f7384 385 SUPERFAMILY SSF56059 226 344 4.71E-9 T 09-03-2017 TK78_RS03085 df33831f635059247ef5e6dd964f7384 385 Gene3D G3DSA:3.30.1490.20 121 191 2.0E-4 T 09-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 TK78_RS05255 11e1a583eff92f21c310762a6edd411a 380 Pfam PF13478 XdhC Rossmann domain 206 348 6.0E-42 T 09-03-2017 IPR027051 XdhC Rossmann domain TK78_RS05255 11e1a583eff92f21c310762a6edd411a 380 Pfam PF02625 XdhC and CoxI family 11 78 2.7E-22 T 09-03-2017 IPR003777 XdhC- CoxI TK78_RS05255 11e1a583eff92f21c310762a6edd411a 380 Pfam PF02625 XdhC and CoxI family 118 178 2.7E-9 T 09-03-2017 IPR003777 XdhC- CoxI TK78_RS15420 08e6b8ed549c0473adb68325fb42197d 248 SUPERFAMILY SSF48150 5 211 5.5E-68 T 09-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 TK78_RS15420 08e6b8ed549c0473adb68325fb42197d 248 ProSitePatterns PS00764 Endonuclease III iron-sulfur binding region signature. 186 202 - T 09-03-2017 IPR004035 Endonuclease III, iron-sulphur binding site Reactome: R-HSA-110330|Reactome: R-HSA-110331|Reactome: R-HSA-110357 TK78_RS15420 08e6b8ed549c0473adb68325fb42197d 248 ProSitePatterns PS01155 Endonuclease III family signature. 101 130 - T 09-03-2017 IPR004036 Endonuclease III-like, conserved site-2 Reactome: R-HSA-110357 TK78_RS15420 08e6b8ed549c0473adb68325fb42197d 248 Hamap MF_00942 Endonuclease III [nth]. 1 208 37.92 T 09-03-2017 IPR005759 Endonuclease III GO:0003906|GO:0006284 TK78_RS15420 08e6b8ed549c0473adb68325fb42197d 248 Pfam PF10576 Iron-sulfur binding domain of endonuclease III 186 202 3.2E-5 T 09-03-2017 IPR003651 Endonuclease III-like, iron-sulphur cluster loop motif GO:0051539 Reactome: R-HSA-110357 TK78_RS15420 08e6b8ed549c0473adb68325fb42197d 248 TIGRFAM TIGR01083 nth: endonuclease III 4 193 1.1E-74 T 09-03-2017 IPR005759 Endonuclease III GO:0003906|GO:0006284 TK78_RS15420 08e6b8ed549c0473adb68325fb42197d 248 SMART SM00525 185 205 1.4E-6 T 09-03-2017 IPR003651 Endonuclease III-like, iron-sulphur cluster loop motif GO:0051539 Reactome: R-HSA-110357 TK78_RS15420 08e6b8ed549c0473adb68325fb42197d 248 SMART SM00478 37 184 3.1E-55 T 09-03-2017 IPR003265 HhH-GPD domain GO:0006284 Reactome: R-HSA-110357 TK78_RS15420 08e6b8ed549c0473adb68325fb42197d 248 Pfam PF00633 Helix-hairpin-helix motif 98 125 4.7E-8 T 09-03-2017 IPR000445 Helix-hairpin-helix motif GO:0003677 Reactome: R-HSA-110357 TK78_RS15420 08e6b8ed549c0473adb68325fb42197d 248 Gene3D G3DSA:1.10.1670.10 122 207 5.7E-33 T 09-03-2017 IPR023170 Helix-turn-helix, base-excision DNA repair, C-terminal Reactome: R-HSA-110357 TK78_RS15420 08e6b8ed549c0473adb68325fb42197d 248 Pfam PF00730 HhH-GPD superfamily base excision DNA repair protein 33 162 4.2E-19 T 09-03-2017 IPR003265 HhH-GPD domain GO:0006284 Reactome: R-HSA-110357 TK78_RS15420 08e6b8ed549c0473adb68325fb42197d 248 Gene3D G3DSA:1.10.340.30 22 121 1.4E-36 T 09-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 TK78_RS18825 b2186a87ef5c3d9e6483c2838c8eb8ee 295 SUPERFAMILY SSF53474 221 289 1.59E-31 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS18825 b2186a87ef5c3d9e6483c2838c8eb8ee 295 SUPERFAMILY SSF53474 33 148 1.59E-31 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS18825 b2186a87ef5c3d9e6483c2838c8eb8ee 295 Gene3D G3DSA:3.40.50.1820 37 181 1.9E-38 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS18825 b2186a87ef5c3d9e6483c2838c8eb8ee 295 Gene3D G3DSA:3.40.50.1820 224 289 1.9E-38 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS18825 b2186a87ef5c3d9e6483c2838c8eb8ee 295 Pfam PF12697 Alpha/beta hydrolase family 45 276 3.3E-12 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS07315 f74bb6297840f9adff23ca99e11caa0f 302 SUPERFAMILY SSF101478 11 292 1.2E-53 T 09-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 TK78_RS07315 f74bb6297840f9adff23ca99e11caa0f 302 Pfam PF03747 ADP-ribosylglycohydrolase 17 275 2.9E-46 T 09-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 TK78_RS02365 b6a1c9f31c58eb3f5f82f31fdf7f8e15 147 Pfam PF00072 Response regulator receiver domain 10 130 2.3E-20 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS02365 b6a1c9f31c58eb3f5f82f31fdf7f8e15 147 Gene3D G3DSA:3.40.50.2300 6 133 3.1E-35 T 09-03-2017 TK78_RS02365 b6a1c9f31c58eb3f5f82f31fdf7f8e15 147 SUPERFAMILY SSF52172 6 134 1.28E-32 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS02365 b6a1c9f31c58eb3f5f82f31fdf7f8e15 147 SMART SM00448 8 130 2.9E-26 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS08055 0646b6f24c8a9ff7a42878ff7bd6431a 365 SUPERFAMILY SSF53850 43 360 1.19E-50 T 09-03-2017 TK78_RS08055 0646b6f24c8a9ff7a42878ff7bd6431a 365 Gene3D G3DSA:3.40.190.10 144 294 8.1E-21 T 09-03-2017 TK78_RS08055 0646b6f24c8a9ff7a42878ff7bd6431a 365 TIGRFAM TIGR01254 sfuA: ABC transporter periplasmic binding protein, thiB subfamily 42 359 1.7E-65 T 09-03-2017 IPR005948 Thiamine ABC transporter periplasmic binding protein GO:0005215|GO:0006810|GO:0015888|GO:0030288|GO:0030975 TK78_RS08055 0646b6f24c8a9ff7a42878ff7bd6431a 365 Gene3D G3DSA:3.40.190.10 11 139 4.6E-24 T 09-03-2017 TK78_RS08055 0646b6f24c8a9ff7a42878ff7bd6431a 365 Gene3D G3DSA:3.40.190.10 295 355 4.6E-24 T 09-03-2017 TK78_RS08055 0646b6f24c8a9ff7a42878ff7bd6431a 365 Pfam PF13343 Bacterial extracellular solute-binding protein 94 222 2.1E-20 T 09-03-2017 TK78_RS14375 e0886c6da5a8c41f8a56eb9ae12c8f7d 236 Pfam PF00753 Metallo-beta-lactamase superfamily 34 229 5.0E-22 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS14375 e0886c6da5a8c41f8a56eb9ae12c8f7d 236 SMART SM00849 35 229 1.8E-16 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS14375 e0886c6da5a8c41f8a56eb9ae12c8f7d 236 SUPERFAMILY SSF56281 33 234 1.09E-30 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS14375 e0886c6da5a8c41f8a56eb9ae12c8f7d 236 Gene3D G3DSA:3.60.15.10 33 234 8.7E-32 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS01285 7ae4acc1d05d498071a39f3ab1447650 384 SUPERFAMILY SSF81345 30 377 5.1E-59 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS01285 7ae4acc1d05d498071a39f3ab1447650 384 Gene3D G3DSA:1.10.3470.10 32 379 7.1E-84 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS01285 7ae4acc1d05d498071a39f3ab1447650 384 Pfam PF01032 FecCD transport family 50 333 8.5E-66 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS14830 8825b66b9cd809c98432140ef42ab50c 206 Gene3D G3DSA:3.40.50.720 1 182 5.9E-41 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS14830 8825b66b9cd809c98432140ef42ab50c 206 Pfam PF03807 NADP oxidoreductase coenzyme F420-dependent 2 88 4.7E-11 T 09-03-2017 IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal TK78_RS14830 8825b66b9cd809c98432140ef42ab50c 206 SUPERFAMILY SSF51735 1 187 1.52E-27 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS16270 50da9a8ea78263f421d0d8a04d24f2bf 336 Pfam PF08843 Nucleotidyl transferase AbiEii toxin, Type IV TA system 95 313 3.6E-19 T 09-03-2017 IPR014942 Nucleotidyl transferase AbiEii toxin, Type IV TA system TK78_RS02715 b849d630c02fdc28d7800a06d41d735d 337 SUPERFAMILY SSF117892 60 191 2.22E-7 T 09-03-2017 IPR001107 Band 7 domain TK78_RS02715 b849d630c02fdc28d7800a06d41d735d 337 Pfam PF01145 SPFH domain / Band 7 family 26 197 1.6E-16 T 09-03-2017 IPR001107 Band 7 domain TK78_RS01765 021ad7e6955056c00405464b269b3578 539 Pfam PF07690 Major Facilitator Superfamily 38 430 5.4E-48 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS01765 021ad7e6955056c00405464b269b3578 539 Gene3D G3DSA:1.20.1250.20 34 219 1.4E-33 T 09-03-2017 TK78_RS01765 021ad7e6955056c00405464b269b3578 539 SUPERFAMILY SSF103473 32 224 3.27E-60 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS01765 021ad7e6955056c00405464b269b3578 539 SUPERFAMILY SSF103473 503 527 3.27E-60 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS01765 021ad7e6955056c00405464b269b3578 539 SUPERFAMILY SSF103473 270 440 3.27E-60 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS01765 021ad7e6955056c00405464b269b3578 539 Gene3D G3DSA:1.20.1250.20 504 533 4.6E-16 T 09-03-2017 TK78_RS01765 021ad7e6955056c00405464b269b3578 539 Gene3D G3DSA:1.20.1250.20 294 441 4.6E-16 T 09-03-2017 TK78_RS22575 f91b914e001af4ab3e75dc30a6ec116f 196 SUPERFAMILY SSF52499 2 192 7.33E-51 T 09-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 TK78_RS22575 f91b914e001af4ab3e75dc30a6ec116f 196 Gene3D G3DSA:3.40.50.850 1 191 1.4E-60 T 09-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 TK78_RS22575 f91b914e001af4ab3e75dc30a6ec116f 196 Pfam PF00857 Isochorismatase family 4 191 6.6E-33 T 09-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 TK78_RS03000 16e0a8b5cdab6b1b58ef24d418784c78 123 Pfam PF05331 Protein of unknown function (DUF742) 13 122 7.8E-33 T 09-03-2017 IPR007995 Protein of unknown function DUF742 TK78_RS21190 5aa34644eac03cab9c6c02811355c7c8 288 Gene3D G3DSA:3.20.20.140 9 287 6.7E-76 T 09-03-2017 TK78_RS21190 5aa34644eac03cab9c6c02811355c7c8 288 SUPERFAMILY SSF51556 16 287 1.75E-70 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS21190 5aa34644eac03cab9c6c02811355c7c8 288 Pfam PF01026 TatD related DNase 19 286 2.9E-65 T 09-03-2017 IPR001130 TatD family GO:0016788 TK78_RS21190 5aa34644eac03cab9c6c02811355c7c8 288 PIRSF PIRSF005902 9 288 1.5E-66 T 09-03-2017 IPR001130 TatD family GO:0016788 TK78_RS23755 dcdd46bb53a50a6adb3f63ef84432bfd 449 Gene3D G3DSA:1.20.1250.20 8 192 4.8E-17 T 09-03-2017 TK78_RS23755 dcdd46bb53a50a6adb3f63ef84432bfd 449 Gene3D G3DSA:1.20.1250.20 222 393 2.1E-10 T 09-03-2017 TK78_RS23755 dcdd46bb53a50a6adb3f63ef84432bfd 449 SUPERFAMILY SSF103473 8 393 1.96E-37 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS23755 dcdd46bb53a50a6adb3f63ef84432bfd 449 Pfam PF07690 Major Facilitator Superfamily 14 359 1.2E-25 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS21035 6a1622b0ac718500792387278904149a 743 SUPERFAMILY SSF82866 464 697 1.7E-29 T 09-03-2017 TK78_RS21035 6a1622b0ac718500792387278904149a 743 Gene3D G3DSA:1.20.1640.10 135 340 3.6E-34 T 09-03-2017 TK78_RS21035 6a1622b0ac718500792387278904149a 743 Gene3D G3DSA:1.20.1640.10 479 703 2.9E-36 T 09-03-2017 TK78_RS21035 6a1622b0ac718500792387278904149a 743 Pfam PF03176 MMPL family 45 368 7.7E-80 T 09-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 TK78_RS21035 6a1622b0ac718500792387278904149a 743 Pfam PF03176 MMPL family 449 698 4.2E-37 T 09-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 TK78_RS21035 6a1622b0ac718500792387278904149a 743 SUPERFAMILY SSF82866 122 334 1.44E-31 T 09-03-2017 TK78_RS08855 0052fbac3f1a8d3bdd552905350e857a 98 SUPERFAMILY SSF141000 4 94 1.24E-26 T 09-03-2017 IPR003837 Glu-tRNAGln amidotransferase C subunit GO:0006450 TK78_RS08855 0052fbac3f1a8d3bdd552905350e857a 98 Pfam PF02686 Glu-tRNAGln amidotransferase C subunit 23 91 1.8E-15 T 09-03-2017 IPR003837 Glu-tRNAGln amidotransferase C subunit GO:0006450 TK78_RS08855 0052fbac3f1a8d3bdd552905350e857a 98 TIGRFAM TIGR00135 gatC: aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit 4 95 7.4E-24 T 09-03-2017 IPR003837 Glu-tRNAGln amidotransferase C subunit GO:0006450 TK78_RS08855 0052fbac3f1a8d3bdd552905350e857a 98 Hamap MF_00122 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C [gatC]. 3 96 23.644 T 09-03-2017 IPR003837 Glu-tRNAGln amidotransferase C subunit GO:0006450 TK78_RS15445 0e5795bf3ddd919327f760c0098c3ac7 324 Gene3D G3DSA:3.40.50.300 6 227 9.2E-36 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15445 0e5795bf3ddd919327f760c0098c3ac7 324 Pfam PF02374 Anion-transporting ATPase 4 180 2.8E-19 T 09-03-2017 IPR025723 Anion-transporting ATPase-like domain Reactome: R-HSA-381038 TK78_RS15445 0e5795bf3ddd919327f760c0098c3ac7 324 SUPERFAMILY SSF52540 6 225 1.11E-28 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27365 a9a1f1b5c31d1756e3f86f085eeec320 319 Pfam PF01790 Prolipoprotein diacylglyceryl transferase 13 254 4.7E-63 T 09-03-2017 IPR001640 Prolipoprotein diacylglyceryl transferase GO:0009249|GO:0016020|GO:0016757|GO:0042158 TK78_RS27365 a9a1f1b5c31d1756e3f86f085eeec320 319 TIGRFAM TIGR00544 lgt: prolipoprotein diacylglyceryl transferase 7 256 2.5E-40 T 09-03-2017 IPR001640 Prolipoprotein diacylglyceryl transferase GO:0009249|GO:0016020|GO:0016757|GO:0042158 TK78_RS27365 a9a1f1b5c31d1756e3f86f085eeec320 319 Hamap MF_01147 Prolipoprotein diacylglyceryl transferase [lgt]. 8 260 15.184 T 09-03-2017 IPR001640 Prolipoprotein diacylglyceryl transferase GO:0009249|GO:0016020|GO:0016757|GO:0042158 TK78_RS27365 a9a1f1b5c31d1756e3f86f085eeec320 319 ProSitePatterns PS01311 Prolipoprotein diacylglyceryl transferase signature. 140 152 - T 09-03-2017 IPR001640 Prolipoprotein diacylglyceryl transferase GO:0009249|GO:0016020|GO:0016757|GO:0042158 TK78_RS28415 d29a916d9ff93476ad091f128a40fc29 507 SUPERFAMILY SSF111283 14 498 2.62E-94 T 09-03-2017 TK78_RS28415 d29a916d9ff93476ad091f128a40fc29 507 Pfam PF01523 Putative modulator of DNA gyrase 32 347 2.1E-48 T 09-03-2017 IPR002510 Metalloprotease TldD/PmbA GO:0006508|GO:0008237 TK78_RS00140 7019221d309e55106e8ecaaba3e43c24 333 SUPERFAMILY SSF51430 8 314 2.62E-56 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS00140 7019221d309e55106e8ecaaba3e43c24 333 Pfam PF00248 Aldo/keto reductase family 18 313 6.3E-40 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS00140 7019221d309e55106e8ecaaba3e43c24 333 Gene3D G3DSA:3.20.20.100 7 309 1.2E-49 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS11005 3ba5c934a36875e61b8e439decb43441 806 Gene3D G3DSA:3.10.105.10 621 764 2.3E-69 T 09-03-2017 TK78_RS11005 3ba5c934a36875e61b8e439decb43441 806 Gene3D G3DSA:3.10.105.10 370 450 2.3E-69 T 09-03-2017 TK78_RS11005 3ba5c934a36875e61b8e439decb43441 806 Gene3D G3DSA:3.90.76.10 94 189 9.6E-11 T 09-03-2017 TK78_RS11005 3ba5c934a36875e61b8e439decb43441 806 SUPERFAMILY SSF53850 361 453 1.18E-47 T 09-03-2017 TK78_RS11005 3ba5c934a36875e61b8e439decb43441 806 SUPERFAMILY SSF53850 57 300 1.18E-47 T 09-03-2017 TK78_RS11005 3ba5c934a36875e61b8e439decb43441 806 SUPERFAMILY SSF53850 584 793 3.15E-24 T 09-03-2017 TK78_RS11005 3ba5c934a36875e61b8e439decb43441 806 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 107 290 5.7E-23 T 09-03-2017 IPR000914 Solute-binding protein family 5 domain TK78_RS11005 3ba5c934a36875e61b8e439decb43441 806 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 350 455 2.9E-14 T 09-03-2017 IPR000914 Solute-binding protein family 5 domain TK78_RS11005 3ba5c934a36875e61b8e439decb43441 806 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 585 693 8.5E-6 T 09-03-2017 IPR000914 Solute-binding protein family 5 domain TK78_RS11005 3ba5c934a36875e61b8e439decb43441 806 Gene3D G3DSA:3.40.190.10 190 291 4.5E-16 T 09-03-2017 TK78_RS29870 905860edfb8596a71c448eca63abfd11 386 SUPERFAMILY SSF51695 53 376 6.02E-78 T 09-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 TK78_RS29870 905860edfb8596a71c448eca63abfd11 386 Gene3D G3DSA:3.20.20.190 54 376 1.2E-89 T 09-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 TK78_RS29870 905860edfb8596a71c448eca63abfd11 386 Pfam PF03009 Glycerophosphoryl diester phosphodiesterase family 59 375 7.7E-45 T 09-03-2017 IPR030395 Glycerophosphodiester phosphodiesterase domain GO:0006629|GO:0008081 TK78_RS32915 4f501ff992de938a0f9e0aee4f13ea72 160 Gene3D G3DSA:3.90.79.10 13 148 1.2E-30 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS32915 4f501ff992de938a0f9e0aee4f13ea72 160 SUPERFAMILY SSF55811 16 136 6.36E-31 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS32915 4f501ff992de938a0f9e0aee4f13ea72 160 Pfam PF00293 NUDIX domain 22 133 1.1E-18 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS32915 4f501ff992de938a0f9e0aee4f13ea72 160 ProSitePatterns PS00893 Nudix box signature. 51 72 - T 09-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 TK78_RS20720 a3cddd810b414674676aca4e5b27e5be 62 SUPERFAMILY SSF47413 4 47 1.65E-9 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS20720 a3cddd810b414674676aca4e5b27e5be 62 Gene3D G3DSA:1.10.260.40 3 46 6.6E-9 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS20720 a3cddd810b414674676aca4e5b27e5be 62 Pfam PF01381 Helix-turn-helix 5 45 1.6E-9 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS22310 a9d76dfd68e9ef40730baa1b6155eb1d 387 Pfam PF01757 Acyltransferase family 25 370 9.4E-23 T 09-03-2017 IPR002656 Acyltransferase 3 GO:0016747 TK78_RS06275 9f577d093617ac12a1948147e6bc79bb 505 Pfam PF02397 Bacterial sugar transferase 312 498 8.8E-55 T 09-03-2017 IPR003362 Bacterial sugar transferase TK78_RS06275 9f577d093617ac12a1948147e6bc79bb 505 TIGRFAM TIGR03025 EPS_sugtrans: exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase 109 505 6.2E-103 T 09-03-2017 IPR017475 Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase TK78_RS08105 58571b9b5ce79e2e72cd7d94285c9c43 370 Pfam PF02481 DNA recombination-mediator protein A 66 271 3.5E-65 T 09-03-2017 IPR003488 DNA recombination-mediator protein A GO:0009294 TK78_RS08105 58571b9b5ce79e2e72cd7d94285c9c43 370 TIGRFAM TIGR00732 dprA: DNA protecting protein DprA 65 278 3.8E-60 T 09-03-2017 IPR003488 DNA recombination-mediator protein A GO:0009294 TK78_RS08105 58571b9b5ce79e2e72cd7d94285c9c43 370 SUPERFAMILY SSF102405 72 280 5.04E-36 T 09-03-2017 TK78_RS08105 58571b9b5ce79e2e72cd7d94285c9c43 370 Gene3D G3DSA:3.40.50.450 106 268 3.8E-15 T 09-03-2017 TK78_RS08105 58571b9b5ce79e2e72cd7d94285c9c43 370 Gene3D G3DSA:1.10.10.10 305 357 1.1E-4 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS08105 58571b9b5ce79e2e72cd7d94285c9c43 370 SUPERFAMILY SSF46785 299 356 8.13E-6 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS06505 42e72098584d8d7e9e295c20744ae45b 350 Gene3D G3DSA:3.40.50.1980 178 314 8.3E-14 T 09-03-2017 TK78_RS06505 42e72098584d8d7e9e295c20744ae45b 350 Gene3D G3DSA:3.40.50.1980 50 177 6.1E-28 T 09-03-2017 TK78_RS06505 42e72098584d8d7e9e295c20744ae45b 350 Pfam PF01497 Periplasmic binding protein 70 312 6.4E-24 T 09-03-2017 IPR002491 ABC transporter periplasmic binding domain GO:0005488 TK78_RS06505 42e72098584d8d7e9e295c20744ae45b 350 SUPERFAMILY SSF53807 52 336 3.85E-47 T 09-03-2017 TK78_RS07595 3aafea651a58b98f38abd878cbca1654 941 SMART SM00843 862 926 1.6E-28 T 09-03-2017 IPR018541 FtsK gamma domain TK78_RS07595 3aafea651a58b98f38abd878cbca1654 941 SMART SM00382 597 795 9.4E-4 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS07595 3aafea651a58b98f38abd878cbca1654 941 SUPERFAMILY SSF52540 538 834 1.6E-46 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07595 3aafea651a58b98f38abd878cbca1654 941 Pfam PF09397 Ftsk gamma domain 866 923 1.4E-21 T 09-03-2017 IPR018541 FtsK gamma domain TK78_RS07595 3aafea651a58b98f38abd878cbca1654 941 Pfam PF01580 FtsK/SpoIIIE family 573 762 1.0E-54 T 09-03-2017 IPR002543 FtsK domain GO:0000166|GO:0003677|GO:0005524 TK78_RS07595 3aafea651a58b98f38abd878cbca1654 941 Gene3D G3DSA:3.40.50.300 539 829 3.4E-82 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07595 3aafea651a58b98f38abd878cbca1654 941 SUPERFAMILY SSF46785 863 928 5.17E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS20245 008eac94f7078d3e071e7ee13b4109b0 598 Pfam PF05140 ResB-like family 63 543 9.3E-128 T 09-03-2017 IPR007816 ResB-like domain TK78_RS19435 92a3474278c69ae4e178dd2e8838dd4a 168 Pfam PF01613 Flavin reductase like domain 11 167 5.0E-37 T 09-03-2017 IPR002563 Flavin reductase like domain GO:0010181 TK78_RS19435 92a3474278c69ae4e178dd2e8838dd4a 168 SUPERFAMILY SSF50475 2 167 2.89E-39 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS19435 92a3474278c69ae4e178dd2e8838dd4a 168 Gene3D G3DSA:2.30.110.10 5 168 1.3E-49 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS19435 92a3474278c69ae4e178dd2e8838dd4a 168 SMART SM00903 10 166 7.0E-50 T 09-03-2017 IPR002563 Flavin reductase like domain GO:0010181 TK78_RS32630 2a795265c253f19cfe4f4227d5fb17fc 252 Pfam PF13649 Methyltransferase domain 60 165 1.8E-16 T 09-03-2017 TK78_RS32630 2a795265c253f19cfe4f4227d5fb17fc 252 Gene3D G3DSA:3.40.50.150 19 226 6.7E-30 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS32630 2a795265c253f19cfe4f4227d5fb17fc 252 SUPERFAMILY SSF53335 8 227 6.69E-32 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS33475 ccff77e5d3fd432543190f3e90f76d4a 291 Pfam PF14339 Domain of unknown function (DUF4394) 53 285 3.3E-73 T 09-03-2017 IPR025507 Domain of unknown function DUF4394 TK78_RS07285 09af365dd46344dac808d73bb170be3d 467 Pfam PF13830 Domain of unknown function (DUF4192) 21 363 6.8E-101 T 09-03-2017 IPR025447 Protein of unknown function DUF4192 TK78_RS23025 b7ace7528f4606e27dc6d342e7ea5299 641 Gene3D G3DSA:3.90.550.10 180 405 6.2E-11 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS23025 b7ace7528f4606e27dc6d342e7ea5299 641 SUPERFAMILY SSF53448 171 433 2.93E-33 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS23025 b7ace7528f4606e27dc6d342e7ea5299 641 Pfam PF13506 Glycosyl transferase family 21 229 398 1.4E-20 T 09-03-2017 IPR025993 Ceramide glucosyltransferase GO:0016757 KEGG: 00600+2.4.1.80|MetaCyc: PWY-5129|Reactome: R-HSA-1660662 TK78_RS26705 26e8ef00d11afd9d8f24f62769cf1092 434 Gene3D G3DSA:3.30.565.10 312 415 1.7E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS26705 26e8ef00d11afd9d8f24f62769cf1092 434 SUPERFAMILY SSF55874 290 415 3.59E-15 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS26705 26e8ef00d11afd9d8f24f62769cf1092 434 Pfam PF07730 Histidine kinase 199 264 2.3E-18 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS04280 1eb1c0a372d2026d0198a21950fa5d64 266 Pfam PF00005 ABC transporter 31 192 1.3E-26 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS04280 1eb1c0a372d2026d0198a21950fa5d64 266 Pfam PF12399 Branched-chain amino acid ATP-binding cassette transporter 241 263 4.0E-10 T 09-03-2017 IPR032823 Branched-chain amino acid ATP-binding cassette transporter, C-terminal TK78_RS04280 1eb1c0a372d2026d0198a21950fa5d64 266 SMART SM00382 40 249 1.4E-4 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS04280 1eb1c0a372d2026d0198a21950fa5d64 266 SUPERFAMILY SSF52540 15 262 2.3E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS04280 1eb1c0a372d2026d0198a21950fa5d64 266 Gene3D G3DSA:3.40.50.300 14 261 2.7E-61 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS12625 f9f4d5b0aa9ecfcd89ed2269f49734f7 422 Gene3D G3DSA:2.60.40.10 315 411 9.3E-5 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS00420 2d8541f8c646485e0eaba30a43fd6b2c 493 SUPERFAMILY SSF53067 4 247 2.65E-48 T 09-03-2017 TK78_RS00420 2d8541f8c646485e0eaba30a43fd6b2c 493 Gene3D G3DSA:3.30.420.40 250 471 3.1E-32 T 09-03-2017 TK78_RS00420 2d8541f8c646485e0eaba30a43fd6b2c 493 Gene3D G3DSA:3.30.420.40 3 244 6.3E-40 T 09-03-2017 TK78_RS00420 2d8541f8c646485e0eaba30a43fd6b2c 493 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 4 244 8.2E-36 T 09-03-2017 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 TK78_RS00420 2d8541f8c646485e0eaba30a43fd6b2c 493 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 274 434 6.9E-20 T 09-03-2017 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 TK78_RS00420 2d8541f8c646485e0eaba30a43fd6b2c 493 SUPERFAMILY SSF53067 251 470 6.11E-37 T 09-03-2017 TK78_RS00420 2d8541f8c646485e0eaba30a43fd6b2c 493 PIRSF PIRSF000538 1 483 1.5E-77 T 09-03-2017 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 TK78_RS26445 61f03f9638bb5136623c9c8686970970 215 Pfam PF00072 Response regulator receiver domain 3 117 1.2E-11 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS26445 61f03f9638bb5136623c9c8686970970 215 SUPERFAMILY SSF52172 1 168 9.23E-18 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS26445 61f03f9638bb5136623c9c8686970970 215 Gene3D G3DSA:3.40.50.2300 2 148 6.8E-24 T 09-03-2017 TK78_RS26445 61f03f9638bb5136623c9c8686970970 215 Gene3D G3DSA:1.10.10.10 149 214 2.3E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS26445 61f03f9638bb5136623c9c8686970970 215 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 181 193 2.3E-10 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS26445 61f03f9638bb5136623c9c8686970970 215 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 151 165 2.3E-10 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS26445 61f03f9638bb5136623c9c8686970970 215 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 165 181 2.3E-10 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS26445 61f03f9638bb5136623c9c8686970970 215 SMART SM00421 148 210 1.4E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS26445 61f03f9638bb5136623c9c8686970970 215 SMART SM00448 1 120 3.2E-7 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS26445 61f03f9638bb5136623c9c8686970970 215 Pfam PF00196 Bacterial regulatory proteins, luxR family 151 195 1.7E-13 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS03105 a8a05898c7b5ebf43531d93cf3010667 279 SUPERFAMILY SSF52266 16 217 1.15E-31 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS03105 a8a05898c7b5ebf43531d93cf3010667 279 Gene3D G3DSA:3.40.50.1110 16 218 2.1E-34 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS03105 a8a05898c7b5ebf43531d93cf3010667 279 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 18 207 7.7E-23 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS29530 05ff2aac8e90af1e2c672cad215435e0 398 Pfam PF03595 Voltage-dependent anion channel 40 375 5.3E-64 T 09-03-2017 IPR004695 Voltage-dependent anion channel GO:0016021|GO:0055085 TK78_RS13895 73f0d63a9a842cf3c3c70b9184368185 336 SUPERFAMILY SSF53807 51 322 1.57E-47 T 09-03-2017 TK78_RS13895 73f0d63a9a842cf3c3c70b9184368185 336 Pfam PF01497 Periplasmic binding protein 70 313 7.5E-28 T 09-03-2017 IPR002491 ABC transporter periplasmic binding domain GO:0005488 TK78_RS13895 73f0d63a9a842cf3c3c70b9184368185 336 Gene3D G3DSA:3.40.50.1980 179 335 4.0E-26 T 09-03-2017 TK78_RS13895 73f0d63a9a842cf3c3c70b9184368185 336 Gene3D G3DSA:3.40.50.1980 50 178 8.1E-27 T 09-03-2017 TK78_RS15120 99a0a1e3f145717127ee3af889910e21 363 ProSitePatterns PS00723 Polyprenyl synthases signature 1. 100 114 - T 09-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 TK78_RS15120 99a0a1e3f145717127ee3af889910e21 363 Pfam PF00348 Polyprenyl synthetase 56 310 1.4E-39 T 09-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 TK78_RS15120 99a0a1e3f145717127ee3af889910e21 363 SUPERFAMILY SSF48576 27 340 2.67E-50 T 09-03-2017 IPR008949 Isoprenoid synthase domain TK78_RS15120 99a0a1e3f145717127ee3af889910e21 363 Gene3D G3DSA:1.10.600.10 28 348 1.0E-54 T 09-03-2017 IPR008949 Isoprenoid synthase domain TK78_RS02850 024a7c0524545767a6cb1466b677c7f2 250 Pfam PF00392 Bacterial regulatory proteins, gntR family 17 73 4.2E-16 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS02850 024a7c0524545767a6cb1466b677c7f2 250 Gene3D G3DSA:1.20.120.530 102 238 3.3E-19 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS02850 024a7c0524545767a6cb1466b677c7f2 250 SMART SM00345 17 80 8.6E-13 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS02850 024a7c0524545767a6cb1466b677c7f2 250 SMART SM00895 105 231 1.1E-12 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS02850 024a7c0524545767a6cb1466b677c7f2 250 SUPERFAMILY SSF48008 103 237 1.26E-18 T 09-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal TK78_RS02850 024a7c0524545767a6cb1466b677c7f2 250 SUPERFAMILY SSF46785 8 74 2.04E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS02850 024a7c0524545767a6cb1466b677c7f2 250 Pfam PF07729 FCD domain 105 230 9.2E-15 T 09-03-2017 IPR011711 GntR, C-terminal TK78_RS02850 024a7c0524545767a6cb1466b677c7f2 250 Gene3D G3DSA:1.10.10.10 4 73 1.6E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS02850 024a7c0524545767a6cb1466b677c7f2 250 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 50 66 9.3E-9 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS02850 024a7c0524545767a6cb1466b677c7f2 250 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 36 50 9.3E-9 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS11700 9970ac32faf29869fc59a419faa08827 282 Gene3D G3DSA:3.40.50.80 138 266 1.2E-37 T 09-03-2017 TK78_RS11700 9970ac32faf29869fc59a419faa08827 282 Pfam PF04954 Siderophore-interacting protein 143 258 1.7E-30 T 09-03-2017 IPR007037 Siderophore-interacting protein TK78_RS11700 9970ac32faf29869fc59a419faa08827 282 Gene3D G3DSA:2.40.30.10 5 133 4.0E-31 T 09-03-2017 TK78_RS11700 9970ac32faf29869fc59a419faa08827 282 Pfam PF08021 Siderophore-interacting FAD-binding domain 12 133 9.4E-32 T 09-03-2017 IPR013113 FAD-binding 9, siderophore-interacting TK78_RS11700 9970ac32faf29869fc59a419faa08827 282 SUPERFAMILY SSF63380 80 133 1.4E-9 T 09-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 TK78_RS11700 9970ac32faf29869fc59a419faa08827 282 SUPERFAMILY SSF63380 8 49 1.4E-9 T 09-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 TK78_RS31230 7a6c9a56f0e009a3dc5e51a84de926b7 301 Gene3D G3DSA:3.40.50.720 1 127 1.1E-27 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31230 7a6c9a56f0e009a3dc5e51a84de926b7 301 SUPERFAMILY SSF55347 123 258 8.83E-35 T 09-03-2017 TK78_RS31230 7a6c9a56f0e009a3dc5e51a84de926b7 301 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 2 121 2.3E-12 T 09-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 TK78_RS31230 7a6c9a56f0e009a3dc5e51a84de926b7 301 SUPERFAMILY SSF51735 1 137 1.95E-32 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31230 7a6c9a56f0e009a3dc5e51a84de926b7 301 Gene3D G3DSA:3.30.360.10 128 299 2.5E-58 T 09-03-2017 TK78_RS09490 8be05e688a1a4084145350fd1d248476 617 Gene3D G3DSA:3.90.550.10 166 389 1.5E-12 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS09490 8be05e688a1a4084145350fd1d248476 617 Pfam PF13506 Glycosyl transferase family 21 211 373 1.8E-17 T 09-03-2017 IPR025993 Ceramide glucosyltransferase GO:0016757 KEGG: 00600+2.4.1.80|MetaCyc: PWY-5129|Reactome: R-HSA-1660662 TK78_RS09490 8be05e688a1a4084145350fd1d248476 617 SUPERFAMILY SSF53448 146 404 3.26E-31 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS20075 e8a641852ea0f702d02f25c1b774aa44 230 Pfam PF14016 Protein of unknown function (DUF4232) 97 221 4.3E-19 T 09-03-2017 IPR025326 Protein of unknown function DUF4232 TK78_RS17925 84dc846890c26d9112ff47767e634093 667 SUPERFAMILY SSF51735 409 521 1.58E-22 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS17925 84dc846890c26d9112ff47767e634093 667 Gene3D G3DSA:3.40.50.720 101 168 3.2E-20 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS17925 84dc846890c26d9112ff47767e634093 667 Gene3D G3DSA:3.40.50.720 16 64 3.2E-20 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS17925 84dc846890c26d9112ff47767e634093 667 Pfam PF02254 TrkA-N domain 413 521 6.4E-20 T 09-03-2017 IPR003148 Regulator of K+ conductance, N-terminal GO:0006813 TK78_RS17925 84dc846890c26d9112ff47767e634093 667 Pfam PF02254 TrkA-N domain 111 168 3.8E-9 T 09-03-2017 IPR003148 Regulator of K+ conductance, N-terminal GO:0006813 TK78_RS17925 84dc846890c26d9112ff47767e634093 667 SUPERFAMILY SSF51735 111 167 1.26E-10 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS17925 84dc846890c26d9112ff47767e634093 667 Gene3D G3DSA:3.40.50.720 411 562 7.7E-30 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS13355 b6a8d589dc3cb414902971c058392597 219 SUPERFAMILY SSF51197 10 210 1.15E-44 T 09-03-2017 TK78_RS13355 b6a8d589dc3cb414902971c058392597 219 Pfam PF13532 2OG-Fe(II) oxygenase superfamily 12 210 3.4E-50 T 09-03-2017 IPR027450 Alpha-ketoglutarate-dependent dioxygenase AlkB-like TK78_RS13355 b6a8d589dc3cb414902971c058392597 219 Gene3D G3DSA:2.60.120.590 9 212 3.5E-50 T 09-03-2017 IPR027450 Alpha-ketoglutarate-dependent dioxygenase AlkB-like TK78_RS14495 538c240238a7498eb58ed5ed096a9c81 109 Gene3D G3DSA:3.10.450.50 9 103 6.1E-9 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS14495 538c240238a7498eb58ed5ed096a9c81 109 SUPERFAMILY SSF54427 8 102 3.51E-8 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS29805 5c9cf824453fa4e6f59965473d77d395 384 Hamap MF_01106 Arginine biosynthesis bifunctional protein ArgJ [argJ]. 1 384 133.815 T 09-03-2017 IPR002813 Arginine biosynthesis protein ArgJ GO:0004358|GO:0006526 KEGG: 00220+2.3.1.35+2.3.1.1|MetaCyc: PWY-5154 TK78_RS29805 5c9cf824453fa4e6f59965473d77d395 384 ProDom PD004193 ACETYLTRANSFERASE ORNITHINE ARGININE BIOSYNTHESIS ARGJ GLUTAMATE N-ACETYLTRANSFERASE TRANSFERASE ACYLTRANSFERASE BIFUNCTIONAL 18 382 0.0 T 09-03-2017 TK78_RS29805 5c9cf824453fa4e6f59965473d77d395 384 Pfam PF01960 ArgJ family 11 384 6.2E-127 T 09-03-2017 IPR002813 Arginine biosynthesis protein ArgJ GO:0004358|GO:0006526 KEGG: 00220+2.3.1.35+2.3.1.1|MetaCyc: PWY-5154 TK78_RS29805 5c9cf824453fa4e6f59965473d77d395 384 TIGRFAM TIGR00120 ArgJ: glutamate N-acetyltransferase/amino-acid acetyltransferase 2 383 1.2E-101 T 09-03-2017 IPR002813 Arginine biosynthesis protein ArgJ GO:0004358|GO:0006526 KEGG: 00220+2.3.1.35+2.3.1.1|MetaCyc: PWY-5154 TK78_RS29805 5c9cf824453fa4e6f59965473d77d395 384 SUPERFAMILY SSF56266 7 380 1.28E-126 T 09-03-2017 IPR016117 ArgJ-like domain KEGG: 00220+2.3.1.35+2.3.1.1|MetaCyc: PWY-5154 TK78_RS29805 5c9cf824453fa4e6f59965473d77d395 384 Gene3D G3DSA:3.60.70.12 2 260 6.2E-94 T 09-03-2017 IPR016117 ArgJ-like domain KEGG: 00220+2.3.1.35+2.3.1.1|MetaCyc: PWY-5154 TK78_RS19685 ebf86fa3ce74166880c11f747fc28bc0 390 ProSitePatterns PS00211 ABC transporters family signature. 137 151 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS19685 ebf86fa3ce74166880c11f747fc28bc0 390 Pfam PF00005 ABC transporter 19 164 1.4E-33 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS19685 ebf86fa3ce74166880c11f747fc28bc0 390 TIGRFAM TIGR01186 proV: glycine betaine/L-proline transport ATP binding subunit 14 369 6.1E-104 T 09-03-2017 IPR005892 Glycine betaine transport ATP-binding subunit GO:0005524|GO:0016020|GO:0031460 TK78_RS19685 ebf86fa3ce74166880c11f747fc28bc0 390 SMART SM00382 27 214 2.8E-19 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS19685 ebf86fa3ce74166880c11f747fc28bc0 390 Gene3D G3DSA:3.40.50.300 1 237 3.6E-76 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS19685 ebf86fa3ce74166880c11f747fc28bc0 390 Gene3D G3DSA:3.10.580.10 257 368 1.5E-13 T 09-03-2017 TK78_RS19685 ebf86fa3ce74166880c11f747fc28bc0 390 SUPERFAMILY SSF52540 1 239 4.23E-75 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS19685 ebf86fa3ce74166880c11f747fc28bc0 390 SUPERFAMILY SSF54631 258 375 1.31E-13 T 09-03-2017 TK78_RS08075 9641286d56aa87b8c3e35726f859ed1f 258 Hamap MF_01220_B Uridylate kinase [pyrH]. 18 252 42.216 T 09-03-2017 IPR015963 Uridylate kinase, bacteria GO:0005737|GO:0006221|GO:0033862 KEGG: 00240+2.7.4.22 TK78_RS08075 9641286d56aa87b8c3e35726f859ed1f 258 PIRSF PIRSF005650 17 258 5.4E-88 T 09-03-2017 IPR011817 Uridylate kinase GO:0006221|GO:0009041 KEGG: 00240+2.7.4.22 TK78_RS08075 9641286d56aa87b8c3e35726f859ed1f 258 TIGRFAM TIGR02075 pyrH_bact: UMP kinase 22 252 1.0E-89 T 09-03-2017 IPR015963 Uridylate kinase, bacteria GO:0005737|GO:0006221|GO:0033862 KEGG: 00240+2.7.4.22 TK78_RS08075 9641286d56aa87b8c3e35726f859ed1f 258 SUPERFAMILY SSF53633 22 253 1.17E-67 T 09-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase TK78_RS08075 9641286d56aa87b8c3e35726f859ed1f 258 Gene3D G3DSA:3.40.1160.10 10 252 1.0E-81 T 09-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase TK78_RS08075 9641286d56aa87b8c3e35726f859ed1f 258 Pfam PF00696 Amino acid kinase family 24 230 2.6E-24 T 09-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase TK78_RS32370 4bc84c4b5c692aa03771eba0ef99e39c 776 PIRSF PIRSF000144 21 776 0.0 T 09-03-2017 IPR010046 Oxidoreductase alpha (molybdopterin) subunit GO:0008863|GO:0030151|GO:0051539 TK78_RS32370 4bc84c4b5c692aa03771eba0ef99e39c 776 SUPERFAMILY SSF53706 73 652 2.75E-137 T 09-03-2017 TK78_RS32370 4bc84c4b5c692aa03771eba0ef99e39c 776 Gene3D G3DSA:3.40.50.740 135 208 9.1E-52 T 09-03-2017 TK78_RS32370 4bc84c4b5c692aa03771eba0ef99e39c 776 Gene3D G3DSA:3.40.50.740 415 647 9.1E-52 T 09-03-2017 TK78_RS32370 4bc84c4b5c692aa03771eba0ef99e39c 776 Pfam PF01568 Molydopterin dinucleotide binding domain 661 751 3.4E-7 T 09-03-2017 IPR006657 Molybdopterin dinucleotide-binding domain GO:0016491|GO:0030151|GO:0055114 TK78_RS32370 4bc84c4b5c692aa03771eba0ef99e39c 776 Gene3D G3DSA:3.40.228.10 209 414 2.0E-51 T 09-03-2017 TK78_RS32370 4bc84c4b5c692aa03771eba0ef99e39c 776 Gene3D G3DSA:2.40.40.20 658 717 4.8E-6 T 09-03-2017 TK78_RS32370 4bc84c4b5c692aa03771eba0ef99e39c 776 SUPERFAMILY SSF50692 656 774 1.45E-13 T 09-03-2017 IPR009010 Aspartate decarboxylase-like domain TK78_RS32370 4bc84c4b5c692aa03771eba0ef99e39c 776 TIGRFAM TIGR01701 Fdhalpha-like: oxidoreductase alpha (molybdopterin) subunit 38 772 6.1E-260 T 09-03-2017 IPR010046 Oxidoreductase alpha (molybdopterin) subunit GO:0008863|GO:0030151|GO:0051539 TK78_RS32370 4bc84c4b5c692aa03771eba0ef99e39c 776 Pfam PF00384 Molybdopterin oxidoreductase 135 515 2.8E-26 T 09-03-2017 IPR006656 Molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS31020 d1f7237bb00cdb15075a3a0202c21634 347 Pfam PF01761 3-dehydroquinate synthase 70 311 3.8E-80 T 09-03-2017 IPR030960 3-dehydroquinate synthase domain KEGG: 00400+4.2.3.4|MetaCyc: PWY-6164 TK78_RS31020 d1f7237bb00cdb15075a3a0202c21634 347 Gene3D G3DSA:1.20.1090.10 174 341 1.0E-40 T 09-03-2017 TK78_RS31020 d1f7237bb00cdb15075a3a0202c21634 347 Hamap MF_00110 3-dehydroquinate synthase [aroB]. 12 342 30.627 T 09-03-2017 IPR016037 3-dehydroquinate synthase AroB GO:0003856|GO:0005737|GO:0009073 KEGG: 00400+4.2.3.4|MetaCyc: PWY-6164 TK78_RS31020 d1f7237bb00cdb15075a3a0202c21634 347 Gene3D G3DSA:3.40.50.1970 13 173 3.7E-48 T 09-03-2017 TK78_RS31020 d1f7237bb00cdb15075a3a0202c21634 347 SUPERFAMILY SSF56796 14 341 1.27E-89 T 09-03-2017 TK78_RS27320 03d5487031ba116654d57dbadc196cb0 497 SUPERFAMILY SSF56322 14 489 1.57E-158 T 09-03-2017 IPR005801 ADC synthase GO:0009058 TK78_RS27320 03d5487031ba116654d57dbadc196cb0 497 PRINTS PR00095 Anthranilate synthase component I signature 342 355 6.1E-24 T 09-03-2017 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 TK78_RS27320 03d5487031ba116654d57dbadc196cb0 497 PRINTS PR00095 Anthranilate synthase component I signature 328 341 6.1E-24 T 09-03-2017 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 TK78_RS27320 03d5487031ba116654d57dbadc196cb0 497 PRINTS PR00095 Anthranilate synthase component I signature 422 436 6.1E-24 T 09-03-2017 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 TK78_RS27320 03d5487031ba116654d57dbadc196cb0 497 PRINTS PR00095 Anthranilate synthase component I signature 437 451 6.1E-24 T 09-03-2017 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 TK78_RS27320 03d5487031ba116654d57dbadc196cb0 497 Gene3D G3DSA:3.60.120.10 14 491 7.1E-175 T 09-03-2017 IPR005801 ADC synthase GO:0009058 TK78_RS27320 03d5487031ba116654d57dbadc196cb0 497 Pfam PF04715 Anthranilate synthase component I, N terminal region 26 170 2.3E-32 T 09-03-2017 IPR006805 Anthranilate synthase component I, N-terminal GO:0009058|GO:0016833 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 TK78_RS27320 03d5487031ba116654d57dbadc196cb0 497 TIGRFAM TIGR00564 trpE_most: anthranilate synthase component I 25 489 1.1E-174 T 09-03-2017 IPR005256 Anthranilate synthase component I, PabB-like GO:0000162|GO:0004049 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 TK78_RS27320 03d5487031ba116654d57dbadc196cb0 497 Pfam PF00425 chorismate binding enzyme 228 480 3.0E-99 T 09-03-2017 IPR015890 Chorismate-utilising enzyme, C-terminal TK78_RS23995 de66d961985cf601e84138e30dcd4978 155 Pfam PF08592 Domain of unknown function (DUF1772) 22 154 3.4E-18 T 09-03-2017 IPR013901 Protein of unknown function DUF1772 TK78_RS06385 d270d358bfdb140106fc17254afca528 272 Pfam PF07848 PaaX-like protein 7 74 1.6E-18 T 09-03-2017 IPR012906 PaaX-like, N-terminal TK78_RS06385 d270d358bfdb140106fc17254afca528 272 PIRSF PIRSF020623 2 272 1.1E-86 T 09-03-2017 IPR011965 Phenylacetic acid degradation operon negative regulatory protein PaaX GO:0006351 TK78_RS06385 d270d358bfdb140106fc17254afca528 272 Gene3D G3DSA:1.10.10.10 34 80 3.0E-4 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS06385 d270d358bfdb140106fc17254afca528 272 Pfam PF08223 PaaX-like protein C-terminal domain 98 264 1.5E-48 T 09-03-2017 IPR013225 PaaX-like, C-terminal TK78_RS05830 57905d40f335019202a42990294e1e62 262 SUPERFAMILY SSF53597 42 258 1.26E-35 T 09-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 TK78_RS05830 57905d40f335019202a42990294e1e62 262 Pfam PF01872 RibD C-terminal domain 43 236 7.3E-29 T 09-03-2017 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 TK78_RS05830 57905d40f335019202a42990294e1e62 262 Gene3D G3DSA:3.40.430.10 38 259 1.6E-58 T 09-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 TK78_RS09520 c1ac21e8e6a754f8fe8bff0433626e8d 158 SUPERFAMILY SSF46785 7 152 1.76E-28 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS09520 c1ac21e8e6a754f8fe8bff0433626e8d 158 SMART SM00347 34 137 3.8E-17 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS09520 c1ac21e8e6a754f8fe8bff0433626e8d 158 Gene3D G3DSA:1.10.10.10 3 154 2.2E-34 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS09520 c1ac21e8e6a754f8fe8bff0433626e8d 158 Pfam PF12802 MarR family 40 100 1.1E-12 T 09-03-2017 TK78_RS07015 08456599b80e250ef3e7a2a34a3e6ae4 242 Pfam PF13649 Methyltransferase domain 50 139 6.4E-15 T 09-03-2017 TK78_RS07015 08456599b80e250ef3e7a2a34a3e6ae4 242 Gene3D G3DSA:3.40.50.150 6 190 3.2E-39 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS07015 08456599b80e250ef3e7a2a34a3e6ae4 242 SUPERFAMILY SSF53335 8 231 7.47E-37 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS01040 c7712254e69d8adbbb693469dc24859f 507 Gene3D G3DSA:3.40.309.10 272 470 5.0E-57 T 09-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 TK78_RS01040 c7712254e69d8adbbb693469dc24859f 507 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 295 306 - T 09-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 TK78_RS01040 c7712254e69d8adbbb693469dc24859f 507 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 262 269 - T 09-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 TK78_RS01040 c7712254e69d8adbbb693469dc24859f 507 Gene3D G3DSA:3.40.605.10 19 271 1.6E-91 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS01040 c7712254e69d8adbbb693469dc24859f 507 SUPERFAMILY SSF53720 14 498 1.24E-159 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS01040 c7712254e69d8adbbb693469dc24859f 507 Pfam PF00171 Aldehyde dehydrogenase family 35 494 1.5E-159 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS07205 52be8b85298c7d02e9e2e8e30f51a569 818 SUPERFAMILY SSF101904 513 778 5.1E-38 T 09-03-2017 TK78_RS07205 52be8b85298c7d02e9e2e8e30f51a569 818 Pfam PF00521 DNA gyrase/topoisomerase IV, subunit A 42 483 3.0E-144 T 09-03-2017 IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS07205 52be8b85298c7d02e9e2e8e30f51a569 818 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 740 771 0.0073 T 09-03-2017 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 TK78_RS07205 52be8b85298c7d02e9e2e8e30f51a569 818 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 668 714 4.9E-5 T 09-03-2017 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 TK78_RS07205 52be8b85298c7d02e9e2e8e30f51a569 818 Gene3D G3DSA:2.120.10.90 513 802 2.5E-39 T 09-03-2017 TK78_RS07205 52be8b85298c7d02e9e2e8e30f51a569 818 Gene3D G3DSA:3.90.199.10 41 246 3.9E-108 T 09-03-2017 IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta GO:0003677|GO:0003918|GO:0005524|GO:0006259|GO:0006265 Reactome: R-HSA-4615885 TK78_RS07205 52be8b85298c7d02e9e2e8e30f51a569 818 Gene3D G3DSA:3.90.199.10 345 409 3.9E-108 T 09-03-2017 IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta GO:0003677|GO:0003918|GO:0005524|GO:0006259|GO:0006265 Reactome: R-HSA-4615885 TK78_RS07205 52be8b85298c7d02e9e2e8e30f51a569 818 SUPERFAMILY SSF56719 41 498 3.14E-162 T 09-03-2017 IPR013760 DNA topoisomerase, type IIA-like domain GO:0003918|GO:0005524 Reactome: R-HSA-4615885 TK78_RS07205 52be8b85298c7d02e9e2e8e30f51a569 818 Gene3D G3DSA:3.30.1360.40 247 344 4.3E-28 T 09-03-2017 IPR024946 Arginine repressor C-terminal-like domain TK78_RS07205 52be8b85298c7d02e9e2e8e30f51a569 818 SMART SM00434 21 476 6.4E-250 T 09-03-2017 IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS28025 1789926b746025a2c91edfc0b9508ef6 108 Pfam PF00893 Small Multidrug Resistance protein 5 95 4.7E-30 T 09-03-2017 IPR000390 Small multidrug resistance protein family GO:0016021 TK78_RS28025 1789926b746025a2c91edfc0b9508ef6 108 SUPERFAMILY SSF103481 8 106 3.66E-21 T 09-03-2017 TK78_RS05415 6b6731c91628ad3a7f91a1818ceff3fe 261 Pfam PF01144 Coenzyme A transferase 22 223 2.4E-25 T 09-03-2017 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 TK78_RS05415 6b6731c91628ad3a7f91a1818ceff3fe 261 SUPERFAMILY SSF100950 11 259 2.13E-60 T 09-03-2017 TK78_RS05415 6b6731c91628ad3a7f91a1818ceff3fe 261 Gene3D G3DSA:3.40.810.20 10 260 7.7E-84 T 09-03-2017 TK78_RS05415 6b6731c91628ad3a7f91a1818ceff3fe 261 SMART SM00882 16 224 2.7E-19 T 09-03-2017 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 TK78_RS07765 3b36ee8782317c71f751787bf3996467 358 SUPERFAMILY SSF52540 29 275 6.83E-65 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07765 3b36ee8782317c71f751787bf3996467 358 Pfam PF00005 ABC transporter 50 204 1.3E-25 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS07765 3b36ee8782317c71f751787bf3996467 358 ProSitePatterns PS00211 ABC transporters family signature. 177 191 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS07765 3b36ee8782317c71f751787bf3996467 358 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 254 341 9.9E-22 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS07765 3b36ee8782317c71f751787bf3996467 358 Gene3D G3DSA:3.40.50.300 28 276 1.6E-71 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07765 3b36ee8782317c71f751787bf3996467 358 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 256 322 1.9E-14 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS07765 3b36ee8782317c71f751787bf3996467 358 SMART SM00382 58 262 2.5E-18 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS19160 5d1948fde195f6b12e90488561a3283c 327 SUPERFAMILY SSF50475 3 82 6.82E-5 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS19160 5d1948fde195f6b12e90488561a3283c 327 Gene3D G3DSA:2.30.110.10 186 308 1.2E-8 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS19160 5d1948fde195f6b12e90488561a3283c 327 Gene3D G3DSA:2.30.110.10 3 88 1.0E-5 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS19160 5d1948fde195f6b12e90488561a3283c 327 SUPERFAMILY SSF50475 186 300 1.05E-9 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS11855 b4e5dbfe204edd3c99a5e3ceea46cda1 176 ProSitePatterns PS01117 MarR-type HTH domain signature. 88 122 - T 09-03-2017 IPR023187 Transcriptional regulator MarR-type, conserved site TK78_RS11855 b4e5dbfe204edd3c99a5e3ceea46cda1 176 SMART SM00347 58 149 9.8E-17 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS11855 b4e5dbfe204edd3c99a5e3ceea46cda1 176 Pfam PF01047 MarR family 59 114 7.4E-13 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS11855 b4e5dbfe204edd3c99a5e3ceea46cda1 176 Gene3D G3DSA:1.10.10.10 28 163 2.3E-31 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS11855 b4e5dbfe204edd3c99a5e3ceea46cda1 176 PRINTS PR00598 Bacterial regulatory protein MarR family signature 73 89 7.8E-8 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS11855 b4e5dbfe204edd3c99a5e3ceea46cda1 176 PRINTS PR00598 Bacterial regulatory protein MarR family signature 90 105 7.8E-8 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS11855 b4e5dbfe204edd3c99a5e3ceea46cda1 176 PRINTS PR00598 Bacterial regulatory protein MarR family signature 109 125 7.8E-8 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS11855 b4e5dbfe204edd3c99a5e3ceea46cda1 176 PRINTS PR00598 Bacterial regulatory protein MarR family signature 139 159 7.8E-8 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS11855 b4e5dbfe204edd3c99a5e3ceea46cda1 176 SUPERFAMILY SSF46785 41 163 5.4E-28 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS16985 b458e0fd09debbb48f72633eb8a2f91b 648 SUPERFAMILY SSF81296 43 142 5.6E-22 T 09-03-2017 IPR014756 Immunoglobulin E-set TK78_RS16985 b458e0fd09debbb48f72633eb8a2f91b 648 Pfam PF04234 CopC domain 44 142 5.3E-24 T 09-03-2017 IPR007348 CopC domain GO:0005507|GO:0042597|GO:0046688 TK78_RS16985 b458e0fd09debbb48f72633eb8a2f91b 648 Pfam PF05425 Copper resistance protein D 353 420 4.9E-18 T 09-03-2017 IPR008457 Copper resistance protein D GO:0016021 TK78_RS16985 b458e0fd09debbb48f72633eb8a2f91b 648 Gene3D G3DSA:2.60.40.1220 43 142 9.1E-27 T 09-03-2017 IPR014755 Copper resistance protein CopC/internalin, immunoglobulin-like TK78_RS01080 ac50368f0adc44052ad60c778ad7d8c8 121 Gene3D G3DSA:1.10.357.10 28 85 1.9E-4 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS33450 8e259b32715d6cfcacbf595ee1b30bf4 336 SMART SM00382 34 217 9.2E-12 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS33450 8e259b32715d6cfcacbf595ee1b30bf4 336 TIGRFAM TIGR01188 drrA: daunorubicin resistance ABC transporter, ATP-binding protein 17 314 1.2E-96 T 09-03-2017 IPR005894 Daunorubicin resistance ABC transporter ATP-binding subunit DrrA GO:0005524|GO:0043215|GO:1900753 TK78_RS33450 8e259b32715d6cfcacbf595ee1b30bf4 336 SUPERFAMILY SSF52540 8 230 4.39E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33450 8e259b32715d6cfcacbf595ee1b30bf4 336 Gene3D G3DSA:3.40.50.300 4 234 7.3E-67 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33450 8e259b32715d6cfcacbf595ee1b30bf4 336 ProSitePatterns PS00211 ABC transporters family signature. 141 155 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS33450 8e259b32715d6cfcacbf595ee1b30bf4 336 Pfam PF00005 ABC transporter 25 168 2.1E-23 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS20225 1ce67b136349ea09937e821f62280d7e 434 SUPERFAMILY SSF53474 180 417 4.45E-39 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS20225 1ce67b136349ea09937e821f62280d7e 434 Pfam PF00756 Putative esterase 201 418 3.4E-22 T 09-03-2017 IPR000801 Putative esterase Reactome: R-HSA-156590 TK78_RS20225 1ce67b136349ea09937e821f62280d7e 434 SUPERFAMILY SSF81296 38 175 2.1E-31 T 09-03-2017 IPR014756 Immunoglobulin E-set TK78_RS20225 1ce67b136349ea09937e821f62280d7e 434 Pfam PF11806 Domain of unknown function (DUF3327) 65 180 1.5E-29 T 09-03-2017 IPR021764 Enterochelin esterase, N-terminal GO:0005506|GO:0005737|GO:0006826|GO:0008849 TK78_RS20225 1ce67b136349ea09937e821f62280d7e 434 Gene3D G3DSA:2.60.40.10 34 168 1.5E-36 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS20225 1ce67b136349ea09937e821f62280d7e 434 Gene3D G3DSA:3.40.50.1820 176 422 2.4E-57 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04490 50d0fe026576cb1dd1f11a53d25014d2 195 SUPERFAMILY SSF47413 20 82 4.79E-14 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS04490 50d0fe026576cb1dd1f11a53d25014d2 195 SUPERFAMILY SSF51182 64 189 2.05E-17 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS04490 50d0fe026576cb1dd1f11a53d25014d2 195 SMART SM00530 24 79 7.6E-14 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS04490 50d0fe026576cb1dd1f11a53d25014d2 195 Gene3D G3DSA:2.60.120.10 99 188 9.9E-15 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS04490 50d0fe026576cb1dd1f11a53d25014d2 195 Pfam PF07883 Cupin domain 131 186 1.1E-9 T 09-03-2017 IPR013096 Cupin 2, conserved barrel TK78_RS04490 50d0fe026576cb1dd1f11a53d25014d2 195 Gene3D G3DSA:1.10.260.40 21 94 2.4E-16 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS04490 50d0fe026576cb1dd1f11a53d25014d2 195 Pfam PF01381 Helix-turn-helix 26 79 1.4E-11 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS17050 07d5b93ea41e636d351643b3d1be13cc 180 SUPERFAMILY SSF56399 7 176 1.01E-59 T 09-03-2017 TK78_RS17050 07d5b93ea41e636d351643b3d1be13cc 180 Pfam PF01885 RNA 2'-phosphotransferase, Tpt1 / KptA family 5 168 6.3E-40 T 09-03-2017 IPR002745 Phosphotransferase KptA/Tpt1 GO:0006388|GO:0016772 TK78_RS17050 07d5b93ea41e636d351643b3d1be13cc 180 Hamap MF_00299 Probable RNA 2'-phosphotransferase [kptA]. 5 176 34.16 T 09-03-2017 IPR022928 RNA 2'-phosphotransferase KptA, putative GO:0016773 TK78_RS10475 4f84af3df705cf25f386abb86a855aac 134 SUPERFAMILY SSF54631 1 122 8.21E-30 T 09-03-2017 TK78_RS10475 4f84af3df705cf25f386abb86a855aac 134 Gene3D G3DSA:3.10.580.10 1 121 2.5E-30 T 09-03-2017 TK78_RS10475 4f84af3df705cf25f386abb86a855aac 134 SMART SM00116 75 122 1.6E-5 T 09-03-2017 IPR000644 CBS domain TK78_RS10475 4f84af3df705cf25f386abb86a855aac 134 SMART SM00116 10 58 8.0E-4 T 09-03-2017 IPR000644 CBS domain TK78_RS10475 4f84af3df705cf25f386abb86a855aac 134 Pfam PF00571 CBS domain 73 120 3.0E-12 T 09-03-2017 IPR000644 CBS domain TK78_RS10475 4f84af3df705cf25f386abb86a855aac 134 Pfam PF00571 CBS domain 3 57 5.8E-9 T 09-03-2017 IPR000644 CBS domain TK78_RS12745 e8bdaef5716535e6ff828749d194ea0e 447 Gene3D G3DSA:2.60.40.420 277 431 6.1E-34 T 09-03-2017 IPR008972 Cupredoxin TK78_RS12745 e8bdaef5716535e6ff828749d194ea0e 447 ProSitePatterns PS00080 Multicopper oxidases signature 2. 414 425 - T 09-03-2017 IPR002355 Multicopper oxidase, copper-binding site GO:0005507 TK78_RS12745 e8bdaef5716535e6ff828749d194ea0e 447 Gene3D G3DSA:2.60.40.420 3 130 3.3E-35 T 09-03-2017 IPR008972 Cupredoxin TK78_RS12745 e8bdaef5716535e6ff828749d194ea0e 447 SUPERFAMILY SSF49503 4 128 6.72E-34 T 09-03-2017 IPR008972 Cupredoxin TK78_RS12745 e8bdaef5716535e6ff828749d194ea0e 447 Pfam PF07732 Multicopper oxidase 14 128 7.3E-31 T 09-03-2017 IPR011707 Multicopper oxidase, type 3 GO:0005507 TK78_RS12745 e8bdaef5716535e6ff828749d194ea0e 447 SUPERFAMILY SSF49503 323 431 7.34E-30 T 09-03-2017 IPR008972 Cupredoxin TK78_RS12745 e8bdaef5716535e6ff828749d194ea0e 447 Pfam PF00394 Multicopper oxidase 188 248 8.0E-6 T 09-03-2017 IPR001117 Multicopper oxidase, type 1 GO:0016491|GO:0055114 TK78_RS12745 e8bdaef5716535e6ff828749d194ea0e 447 SUPERFAMILY SSF49503 134 250 7.17E-22 T 09-03-2017 IPR008972 Cupredoxin TK78_RS12745 e8bdaef5716535e6ff828749d194ea0e 447 Gene3D G3DSA:2.60.40.420 131 272 7.9E-27 T 09-03-2017 IPR008972 Cupredoxin TK78_RS12745 e8bdaef5716535e6ff828749d194ea0e 447 Pfam PF07731 Multicopper oxidase 317 433 6.9E-25 T 09-03-2017 IPR011706 Multicopper oxidase, type 2 GO:0005507|GO:0016491|GO:0055114 TK78_RS02285 f3b594df48df0dc597c5018771d0fb96 396 SMART SM00387 280 390 1.4E-5 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS02285 f3b594df48df0dc597c5018771d0fb96 396 Gene3D G3DSA:3.30.565.10 247 388 5.5E-15 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS02285 f3b594df48df0dc597c5018771d0fb96 396 SUPERFAMILY SSF55874 247 387 1.57E-18 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS02285 f3b594df48df0dc597c5018771d0fb96 396 Pfam PF06580 Histidine kinase 191 269 4.1E-23 T 09-03-2017 IPR010559 Signal transduction histidine kinase, internal region GO:0000155|GO:0000160|GO:0016021 TK78_RS02285 f3b594df48df0dc597c5018771d0fb96 396 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 289 388 9.0E-9 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS05680 63f014d62a98fe91dca7a0d0bc583630 586 SUPERFAMILY SSF51445 74 505 2.26E-104 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS05680 63f014d62a98fe91dca7a0d0bc583630 586 Gene3D G3DSA:2.60.40.10 2 77 2.6E-24 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS05680 63f014d62a98fe91dca7a0d0bc583630 586 SMART SM00642 72 446 2.0E-7 T 09-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 TK78_RS05680 63f014d62a98fe91dca7a0d0bc583630 586 SUPERFAMILY SSF81296 2 76 4.2E-14 T 09-03-2017 IPR014756 Immunoglobulin E-set TK78_RS05680 63f014d62a98fe91dca7a0d0bc583630 586 Gene3D G3DSA:3.20.20.80 470 505 3.4E-76 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS05680 63f014d62a98fe91dca7a0d0bc583630 586 Gene3D G3DSA:3.20.20.80 91 427 3.4E-76 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS05680 63f014d62a98fe91dca7a0d0bc583630 586 TIGRFAM TIGR02402 trehalose_TreZ: malto-oligosyltrehalose trehalohydrolase 2 543 1.2E-225 T 09-03-2017 IPR012768 Malto-oligosyltrehalose trehalohydrolase GO:0004553|GO:0005992 KEGG: 00520+3.2.1.14|MetaCyc: PWY-2661|MetaCyc: PWY-6902 TK78_RS05680 63f014d62a98fe91dca7a0d0bc583630 586 Pfam PF00128 Alpha amylase, catalytic domain 115 189 2.1E-9 T 09-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 TK78_RS05680 63f014d62a98fe91dca7a0d0bc583630 586 PIRSF PIRSF006337 1 583 3.9E-222 T 09-03-2017 IPR012768 Malto-oligosyltrehalose trehalohydrolase GO:0004553|GO:0005992 KEGG: 00520+3.2.1.14|MetaCyc: PWY-2661|MetaCyc: PWY-6902 TK78_RS05680 63f014d62a98fe91dca7a0d0bc583630 586 Pfam PF11941 Domain of unknown function (DUF3459) 490 583 1.3E-19 T 09-03-2017 IPR022567 Glycosyl hydrolase, C-terminal (DUF3459) TK78_RS24040 0d0f00cf0ee666a7b1df303c3b52429e 547 SUPERFAMILY SSF52540 39 252 6.14E-18 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24040 0d0f00cf0ee666a7b1df303c3b52429e 547 Pfam PF00350 Dynamin family 63 196 1.4E-5 T 09-03-2017 IPR022812 Dynamin superfamily TK78_RS24040 0d0f00cf0ee666a7b1df303c3b52429e 547 Gene3D G3DSA:3.40.50.300 157 250 2.1E-10 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24040 0d0f00cf0ee666a7b1df303c3b52429e 547 Gene3D G3DSA:3.40.50.300 60 105 2.1E-10 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09485 a88b8efd76f775660dba0a2fbafaa471 651 SUPERFAMILY SSF50965 67 139 1.11E-6 T 09-03-2017 IPR011043 Galactose oxidase/kelch, beta-propeller TK78_RS09485 a88b8efd76f775660dba0a2fbafaa471 651 SUPERFAMILY SSF50965 270 549 3.27E-29 T 09-03-2017 IPR011043 Galactose oxidase/kelch, beta-propeller TK78_RS09485 a88b8efd76f775660dba0a2fbafaa471 651 Gene3D G3DSA:2.60.40.10 557 650 1.3E-27 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS09485 a88b8efd76f775660dba0a2fbafaa471 651 Gene3D G3DSA:2.130.10.80 264 556 7.2E-68 T 09-03-2017 IPR015916 Galactose oxidase, beta-propeller TK78_RS09485 a88b8efd76f775660dba0a2fbafaa471 651 Gene3D G3DSA:2.130.10.80 52 136 7.2E-68 T 09-03-2017 IPR015916 Galactose oxidase, beta-propeller TK78_RS09485 a88b8efd76f775660dba0a2fbafaa471 651 SUPERFAMILY SSF81296 554 650 1.15E-21 T 09-03-2017 IPR014756 Immunoglobulin E-set TK78_RS09485 a88b8efd76f775660dba0a2fbafaa471 651 Pfam PF09118 Domain of unknown function (DUF1929) 556 650 7.1E-24 T 09-03-2017 IPR015202 Domain of unknown function DUF1929 TK78_RS05635 3f57f91489e70d262a83280a4c2db89d 348 Pfam PF00067 Cytochrome P450 228 285 6.2E-7 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS05635 3f57f91489e70d262a83280a4c2db89d 348 PRINTS PR00359 B-class P450 signature 270 285 1.0E-6 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS05635 3f57f91489e70d262a83280a4c2db89d 348 PRINTS PR00359 B-class P450 signature 133 149 1.0E-6 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS05635 3f57f91489e70d262a83280a4c2db89d 348 PRINTS PR00359 B-class P450 signature 242 269 1.0E-6 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS05635 3f57f91489e70d262a83280a4c2db89d 348 SUPERFAMILY SSF48264 35 346 4.32E-28 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS05635 3f57f91489e70d262a83280a4c2db89d 348 Gene3D G3DSA:1.10.630.10 13 161 6.1E-6 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS05635 3f57f91489e70d262a83280a4c2db89d 348 Gene3D G3DSA:1.10.630.10 186 346 3.4E-26 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS20985 7f3e3bcc05f486f3de2bffb1c540ad00 162 SUPERFAMILY SSF55729 4 159 1.6E-25 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS20985 7f3e3bcc05f486f3de2bffb1c540ad00 162 Pfam PF00583 Acetyltransferase (GNAT) family 54 137 1.6E-12 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS20985 7f3e3bcc05f486f3de2bffb1c540ad00 162 Gene3D G3DSA:3.40.630.30 6 160 4.9E-28 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS17615 68e159e96442712d24692dedea859768 229 Gene3D G3DSA:3.40.1280.10 58 218 8.5E-40 T 09-03-2017 IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal TK78_RS17615 68e159e96442712d24692dedea859768 229 Pfam PF00588 SpoU rRNA Methylase family 77 213 3.3E-23 T 09-03-2017 IPR001537 tRNA/rRNA methyltransferase, SpoU type GO:0003723|GO:0006396|GO:0008173 TK78_RS17615 68e159e96442712d24692dedea859768 229 SUPERFAMILY SSF75217 61 219 9.81E-37 T 09-03-2017 IPR029028 Alpha/beta knot methyltransferases TK78_RS22150 9cbbe29e28cb0b77bac004e0ff330ae3 1671 PIRSF PIRSF036761 36 1671 0.0 T 09-03-2017 IPR007780 NAD-glutamate dehydrogenase, bacteria GO:0004352|GO:0019551 KEGG: 00220+1.4.1.2|KEGG: 00250+1.4.1.2|KEGG: 00430+1.4.1.2|KEGG: 00910+1.4.1.2|MetaCyc: PWY-5022|MetaCyc: PWY-6728|MetaCyc: PWY-7126 TK78_RS22150 9cbbe29e28cb0b77bac004e0ff330ae3 1671 Gene3D G3DSA:3.40.50.720 1171 1243 1.2E-36 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS22150 9cbbe29e28cb0b77bac004e0ff330ae3 1671 Gene3D G3DSA:3.40.50.720 1003 1114 1.2E-36 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS22150 9cbbe29e28cb0b77bac004e0ff330ae3 1671 SUPERFAMILY SSF51735 1006 1108 3.21E-32 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS22150 9cbbe29e28cb0b77bac004e0ff330ae3 1671 SUPERFAMILY SSF51735 1146 1347 3.21E-32 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS22150 9cbbe29e28cb0b77bac004e0ff330ae3 1671 SUPERFAMILY SSF53223 814 1001 2.78E-22 T 09-03-2017 TK78_RS22150 9cbbe29e28cb0b77bac004e0ff330ae3 1671 Pfam PF05088 Bacterial NAD-glutamate dehydrogenase 100 1664 0.0 T 09-03-2017 IPR028971 NAD-glutamate dehydrogenase GO:0004352|GO:0019551 KEGG: 00220+1.4.1.2|KEGG: 00250+1.4.1.2|KEGG: 00430+1.4.1.2|KEGG: 00910+1.4.1.2|MetaCyc: PWY-5022|MetaCyc: PWY-6728|MetaCyc: PWY-7126 TK78_RS07480 b13cbd2e4c665622f786fce85fa06b25 137 Pfam PF00581 Rhodanese-like domain 33 129 2.0E-9 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS07480 b13cbd2e4c665622f786fce85fa06b25 137 SUPERFAMILY SSF52821 18 134 5.5E-22 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS07480 b13cbd2e4c665622f786fce85fa06b25 137 SMART SM00450 29 133 4.0E-17 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS07480 b13cbd2e4c665622f786fce85fa06b25 137 Gene3D G3DSA:3.40.250.10 14 134 1.8E-22 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS16775 047c6e924384ae978a694a6179d76396 140 Gene3D G3DSA:3.10.129.10 5 136 2.7E-19 T 09-03-2017 IPR029069 HotDog domain TK78_RS16775 047c6e924384ae978a694a6179d76396 140 SUPERFAMILY SSF54637 5 136 1.34E-20 T 09-03-2017 IPR029069 HotDog domain TK78_RS16775 047c6e924384ae978a694a6179d76396 140 Pfam PF01575 MaoC like domain 14 109 8.1E-7 T 09-03-2017 IPR002539 MaoC-like domain TK78_RS03720 8a05b3bf86aa901596520396a218eb21 500 Gene3D G3DSA:3.40.309.10 263 461 3.2E-63 T 09-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 TK78_RS03720 8a05b3bf86aa901596520396a218eb21 500 Gene3D G3DSA:3.40.605.10 7 262 2.8E-89 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS03720 8a05b3bf86aa901596520396a218eb21 500 Pfam PF00171 Aldehyde dehydrogenase family 13 486 1.3E-159 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS03720 8a05b3bf86aa901596520396a218eb21 500 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 284 295 - T 09-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 TK78_RS03720 8a05b3bf86aa901596520396a218eb21 500 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 251 258 - T 09-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 TK78_RS03720 8a05b3bf86aa901596520396a218eb21 500 SUPERFAMILY SSF53720 6 492 3.4E-159 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS03255 7c41083e90bbc1b24161b9ab050186f5 255 Pfam PF13649 Methyltransferase domain 42 128 1.1E-11 T 09-03-2017 TK78_RS03255 7c41083e90bbc1b24161b9ab050186f5 255 Gene3D G3DSA:3.40.50.150 7 132 1.4E-23 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS03255 7c41083e90bbc1b24161b9ab050186f5 255 SUPERFAMILY SSF53335 8 137 3.08E-24 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS15450 5282590a7badb2470e929fd494ec7639 474 SUPERFAMILY SSF52540 222 283 3.97E-35 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15450 5282590a7badb2470e929fd494ec7639 474 SUPERFAMILY SSF52540 12 180 3.97E-35 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15450 5282590a7badb2470e929fd494ec7639 474 Pfam PF02374 Anion-transporting ATPase 13 287 2.8E-28 T 09-03-2017 IPR025723 Anion-transporting ATPase-like domain Reactome: R-HSA-381038 TK78_RS15450 5282590a7badb2470e929fd494ec7639 474 Gene3D G3DSA:3.40.50.300 209 286 7.7E-50 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15450 5282590a7badb2470e929fd494ec7639 474 Gene3D G3DSA:3.40.50.300 8 168 7.7E-50 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS32690 34ef9de8398b179cf9628e19bc86a636 359 SUPERFAMILY SSF53383 20 356 4.26E-96 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS32690 34ef9de8398b179cf9628e19bc86a636 359 Gene3D G3DSA:3.90.1150.10 269 355 3.1E-28 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS32690 34ef9de8398b179cf9628e19bc86a636 359 Pfam PF01212 Beta-eliminating lyase 22 308 2.8E-57 T 09-03-2017 IPR001597 Aromatic amino acid beta-eliminating lyase/threonine aldolase GO:0006520|GO:0016829 Reactome: R-HSA-6783984 TK78_RS32690 34ef9de8398b179cf9628e19bc86a636 359 Gene3D G3DSA:3.40.640.10 14 266 8.6E-61 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS34350 3c614b0c9e1a12eedc4d65d485769e9d 221 SUPERFAMILY SSF69593 28 189 7.59E-20 T 09-03-2017 TK78_RS34350 3c614b0c9e1a12eedc4d65d485769e9d 221 Gene3D G3DSA:3.40.1130.10 30 152 3.5E-9 T 09-03-2017 TK78_RS34350 3c614b0c9e1a12eedc4d65d485769e9d 221 SMART SM00563 30 151 2.6E-13 T 09-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 TK78_RS34350 3c614b0c9e1a12eedc4d65d485769e9d 221 Pfam PF01553 Acyltransferase 16 147 2.7E-16 T 09-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 TK78_RS22390 662673d9404862794892a6a8a6abe98d 328 SUPERFAMILY SSF161098 39 323 5.23E-52 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS22390 662673d9404862794892a6a8a6abe98d 328 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 128 323 9.7E-13 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS22390 662673d9404862794892a6a8a6abe98d 328 Gene3D G3DSA:1.10.3720.10 38 318 5.2E-54 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS32075 8c55a10abb7b320faa81308a386c5d27 504 SUPERFAMILY SSF50443 332 500 6.8E-64 T 09-03-2017 IPR004216 L-fucose/L-arabinose isomerase, C-terminal TK78_RS32075 8c55a10abb7b320faa81308a386c5d27 504 SUPERFAMILY SSF53743 7 330 1.67E-107 T 09-03-2017 IPR009015 L-fucose isomerase, N-terminal/central domain GO:0005737|GO:0005996|GO:0016861 TK78_RS32075 8c55a10abb7b320faa81308a386c5d27 504 ProDom PD018364 ISOMERASE L-ARABINOSE ARABINOSE METABOLISM CARBOHYDRATE CATABOLISM ARAA 9 307 2.0E-109 T 09-03-2017 IPR003762 L-arabinose isomerase GO:0008152|GO:0008733 KEGG: 00040+5.3.1.4 TK78_RS32075 8c55a10abb7b320faa81308a386c5d27 504 Hamap MF_00519 L-arabinose isomerase [araA]. 2 479 61.267 T 09-03-2017 IPR003762 L-arabinose isomerase GO:0008152|GO:0008733 KEGG: 00040+5.3.1.4 TK78_RS32075 8c55a10abb7b320faa81308a386c5d27 504 Pfam PF02610 L-arabinose isomerase 7 362 9.2E-166 T 09-03-2017 IPR003762 L-arabinose isomerase GO:0008152|GO:0008733 KEGG: 00040+5.3.1.4 TK78_RS32075 8c55a10abb7b320faa81308a386c5d27 504 PIRSF PIRSF001478 3 502 2.4E-219 T 09-03-2017 IPR003762 L-arabinose isomerase GO:0008152|GO:0008733 KEGG: 00040+5.3.1.4 TK78_RS32075 8c55a10abb7b320faa81308a386c5d27 504 Pfam PF11762 L-arabinose isomerase C-terminal domain 366 478 5.9E-43 T 09-03-2017 IPR024664 L-arabinose isomerase, C-terminal KEGG: 00040+5.3.1.4 TK78_RS12345 82cf65babce48e39ca335acff4090f43 126 TIGRFAM TIGR02970 succ_dehyd_cytB: succinate dehydrogenase, cytochrome b556 subunit 6 111 1.2E-28 T 09-03-2017 IPR014314 Succinate dehydrogenase, cytochrome b556 subunit GO:0000104|GO:0006099|GO:0045281 Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS12345 82cf65babce48e39ca335acff4090f43 126 Gene3D G3DSA:1.20.1300.10 3 113 6.7E-30 T 09-03-2017 TK78_RS12345 82cf65babce48e39ca335acff4090f43 126 Pfam PF01127 Succinate dehydrogenase/Fumarate reductase transmembrane subunit 5 108 9.9E-23 T 09-03-2017 IPR000701 Succinate dehydrogenase/Fumarate reductase, transmembrane subunit GO:0016627 Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS12345 82cf65babce48e39ca335acff4090f43 126 SUPERFAMILY SSF81343 2 113 2.62E-28 T 09-03-2017 TK78_RS11630 c1cc72e70b535e8a7bd7169f59294c9f 136 Pfam PF07811 TadE-like protein 21 63 2.8E-8 T 09-03-2017 IPR012495 TadE-like TK78_RS19460 5f58480258fde7717aee252d1298d844 310 Gene3D G3DSA:3.30.420.40 2 142 8.1E-34 T 09-03-2017 TK78_RS19460 5f58480258fde7717aee252d1298d844 310 SUPERFAMILY SSF53067 4 305 8.9E-55 T 09-03-2017 TK78_RS19460 5f58480258fde7717aee252d1298d844 310 Gene3D G3DSA:3.30.420.40 143 286 8.1E-46 T 09-03-2017 TK78_RS19460 5f58480258fde7717aee252d1298d844 310 Pfam PF00480 ROK family 5 300 6.0E-60 T 09-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 TK78_RS20195 41bed1c1daec8761aabe6a9692cb23fd 273 Gene3D G3DSA:1.10.10.60 226 270 9.3E-6 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS20195 41bed1c1daec8761aabe6a9692cb23fd 273 Gene3D G3DSA:1.10.10.60 170 225 1.3E-6 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS20195 41bed1c1daec8761aabe6a9692cb23fd 273 Pfam PF12833 Helix-turn-helix domain 193 270 3.1E-17 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS20195 41bed1c1daec8761aabe6a9692cb23fd 273 SMART SM00342 187 271 7.7E-13 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS00390 f80ae00a2d2366fac6af1943928e2b56 102 SUPERFAMILY SSF55729 4 94 4.36E-23 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS00390 f80ae00a2d2366fac6af1943928e2b56 102 Gene3D G3DSA:3.40.630.30 3 95 4.3E-25 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS00390 f80ae00a2d2366fac6af1943928e2b56 102 Pfam PF14542 GCN5-related N-acetyl-transferase 13 92 7.2E-25 T 09-03-2017 IPR031165 Yjdj-type Gcn5-related N-acetyltransferase TK78_RS13435 fc808bf294dffdf8af41c0e6964a0586 453 Pfam PF13796 Putative sensor 49 237 3.2E-46 T 09-03-2017 IPR025828 Putative sensor domain TK78_RS13435 fc808bf294dffdf8af41c0e6964a0586 453 SUPERFAMILY SSF55874 348 450 8.35E-13 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS13435 fc808bf294dffdf8af41c0e6964a0586 453 Pfam PF07730 Histidine kinase 265 330 1.1E-13 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS13435 fc808bf294dffdf8af41c0e6964a0586 453 Gene3D G3DSA:3.30.565.10 370 451 3.9E-4 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS04770 717314c6c9cc5a1ec2c94fbda3048774 248 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 188 236 2.6E-12 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS04770 717314c6c9cc5a1ec2c94fbda3048774 248 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 113 163 1.6E-9 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS04770 717314c6c9cc5a1ec2c94fbda3048774 248 SUPERFAMILY SSF81923 99 235 3.38E-26 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS04770 717314c6c9cc5a1ec2c94fbda3048774 248 Gene3D G3DSA:1.10.1780.10 98 236 1.1E-35 T 09-03-2017 IPR004176 Clp, N-terminal GO:0019538 TK78_RS26220 56929801a89f168de4f3b1b3bbf61fc1 337 Pfam PF00005 ABC transporter 30 173 6.1E-27 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS26220 56929801a89f168de4f3b1b3bbf61fc1 337 SUPERFAMILY SSF52540 6 234 4.02E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS26220 56929801a89f168de4f3b1b3bbf61fc1 337 TIGRFAM TIGR01188 drrA: daunorubicin resistance ABC transporter, ATP-binding protein 22 321 1.4E-114 T 09-03-2017 IPR005894 Daunorubicin resistance ABC transporter ATP-binding subunit DrrA GO:0005524|GO:0043215|GO:1900753 TK78_RS26220 56929801a89f168de4f3b1b3bbf61fc1 337 Gene3D G3DSA:3.40.50.300 6 237 3.2E-69 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS26220 56929801a89f168de4f3b1b3bbf61fc1 337 SMART SM00382 39 230 1.2E-8 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS26220 56929801a89f168de4f3b1b3bbf61fc1 337 ProSitePatterns PS00211 ABC transporters family signature. 146 160 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS23695 280fe7e37d3ece49a1877e00d75b376c 494 Pfam PF05576 PS-10 peptidase S37 46 494 1.4E-247 T 09-03-2017 IPR008761 Peptidase S37, tripeptidyl aminopeptidase TK78_RS23695 280fe7e37d3ece49a1877e00d75b376c 494 SUPERFAMILY SSF53474 136 228 8.96E-13 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS23695 280fe7e37d3ece49a1877e00d75b376c 494 SUPERFAMILY SSF53474 378 450 8.96E-13 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS23695 280fe7e37d3ece49a1877e00d75b376c 494 Gene3D G3DSA:3.40.50.1820 80 270 1.5E-9 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS23695 280fe7e37d3ece49a1877e00d75b376c 494 Gene3D G3DSA:3.40.50.1820 333 433 1.5E-9 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS30990 ab1772714ea51f96ddd714f60314d77d 297 Gene3D G3DSA:3.30.420.40 3 134 9.4E-21 T 09-03-2017 TK78_RS30990 ab1772714ea51f96ddd714f60314d77d 297 Gene3D G3DSA:3.30.420.40 135 267 1.9E-35 T 09-03-2017 TK78_RS30990 ab1772714ea51f96ddd714f60314d77d 297 SUPERFAMILY SSF53067 3 291 3.58E-39 T 09-03-2017 TK78_RS30990 ab1772714ea51f96ddd714f60314d77d 297 Pfam PF00480 ROK family 4 292 1.7E-36 T 09-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 TK78_RS30370 3a1e0c5bf293b0d6095b0d3c6a3fa676 310 TIGRFAM TIGR00460 fmt: methionyl-tRNA formyltransferase 1 301 3.4E-68 T 09-03-2017 IPR005794 Methionyl-tRNA formyltransferase GO:0004479|GO:0071951 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9|Reactome: R-HSA-5368286 TK78_RS30370 3a1e0c5bf293b0d6095b0d3c6a3fa676 310 Hamap MF_00182 Methionyl-tRNA formyltransferase [fmt]. 1 303 32.654 T 09-03-2017 IPR005794 Methionyl-tRNA formyltransferase GO:0004479|GO:0071951 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9|Reactome: R-HSA-5368286 TK78_RS30370 3a1e0c5bf293b0d6095b0d3c6a3fa676 310 SUPERFAMILY SSF53328 1 206 9.81E-57 T 09-03-2017 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 TK78_RS30370 3a1e0c5bf293b0d6095b0d3c6a3fa676 310 Pfam PF00551 Formyl transferase 2 177 8.8E-33 T 09-03-2017 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 TK78_RS30370 3a1e0c5bf293b0d6095b0d3c6a3fa676 310 SUPERFAMILY SSF50486 205 308 1.16E-28 T 09-03-2017 IPR011034 Formyl transferase, C-terminal-like GO:0003824 TK78_RS30370 3a1e0c5bf293b0d6095b0d3c6a3fa676 310 Gene3D G3DSA:3.10.25.10 208 309 5.6E-32 T 09-03-2017 IPR005793 Formyl transferase, C-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 TK78_RS30370 3a1e0c5bf293b0d6095b0d3c6a3fa676 310 Gene3D G3DSA:3.40.50.170 1 206 2.6E-59 T 09-03-2017 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 TK78_RS30370 3a1e0c5bf293b0d6095b0d3c6a3fa676 310 Pfam PF02911 Formyl transferase, C-terminal domain 204 300 8.2E-25 T 09-03-2017 IPR005793 Formyl transferase, C-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 TK78_RS13140 f0a18115fdb44faafa5777330a921747 115 Gene3D G3DSA:3.90.470.10 1 112 3.9E-42 T 09-03-2017 IPR001063 Ribosomal protein L22/L17 GO:0003735|GO:0005840|GO:0006412 TK78_RS13140 f0a18115fdb44faafa5777330a921747 115 SUPERFAMILY SSF54843 1 112 5.76E-42 T 09-03-2017 IPR001063 Ribosomal protein L22/L17 GO:0003735|GO:0005840|GO:0006412 TK78_RS13140 f0a18115fdb44faafa5777330a921747 115 Hamap MF_01331_B 50S ribosomal protein L22 [rplV]. 1 111 29.876 T 09-03-2017 IPR005727 Ribosomal protein L22, bacterial/chloroplast-type GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13140 f0a18115fdb44faafa5777330a921747 115 Pfam PF00237 Ribosomal protein L22p/L17e 8 108 1.2E-32 T 09-03-2017 IPR001063 Ribosomal protein L22/L17 GO:0003735|GO:0005840|GO:0006412 TK78_RS13140 f0a18115fdb44faafa5777330a921747 115 TIGRFAM TIGR01044 rplV_bact: ribosomal protein uL22 5 108 5.1E-45 T 09-03-2017 IPR005727 Ribosomal protein L22, bacterial/chloroplast-type GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13140 f0a18115fdb44faafa5777330a921747 115 ProSitePatterns PS00464 Ribosomal protein L22 signature. 84 108 - T 09-03-2017 IPR018260 Ribosomal protein L22/L17, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TK78_RS15190 e99c6ef0bfe334bb2bc690c8e44fa8ca 493 Gene3D G3DSA:3.90.1150.10 361 480 1.1E-29 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS15190 e99c6ef0bfe334bb2bc690c8e44fa8ca 493 Pfam PF00282 Pyridoxal-dependent decarboxylase conserved domain 79 407 1.9E-44 T 09-03-2017 IPR002129 Pyridoxal phosphate-dependent decarboxylase GO:0016831|GO:0019752|GO:0030170 TK78_RS15190 e99c6ef0bfe334bb2bc690c8e44fa8ca 493 SUPERFAMILY SSF53383 51 477 2.09E-94 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS15190 e99c6ef0bfe334bb2bc690c8e44fa8ca 493 Gene3D G3DSA:3.40.640.10 99 360 7.8E-75 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS29235 217d8465d3c783bac621e4e2cc9e605b 240 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 4 202 9.9E-46 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS29235 217d8465d3c783bac621e4e2cc9e605b 240 TIGRFAM TIGR03848 MSMEG_4193: probable phosphomutase, MSMEG_4193 family 3 204 2.3E-93 T 09-03-2017 IPR022492 Phosphomutase MSMEG4193, putative TK78_RS29235 217d8465d3c783bac621e4e2cc9e605b 240 SUPERFAMILY SSF53254 1 212 1.18E-44 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS29235 217d8465d3c783bac621e4e2cc9e605b 240 Gene3D G3DSA:3.40.50.1240 1 218 1.2E-45 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS29235 217d8465d3c783bac621e4e2cc9e605b 240 SMART SM00855 3 162 3.1E-20 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS28110 572c6562c284aa0e88d29677b909e625 220 Gene3D G3DSA:3.40.50.2300 3 128 7.4E-35 T 09-03-2017 TK78_RS28110 572c6562c284aa0e88d29677b909e625 220 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 187 199 5.3E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS28110 572c6562c284aa0e88d29677b909e625 220 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 171 187 5.3E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS28110 572c6562c284aa0e88d29677b909e625 220 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 157 171 5.3E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS28110 572c6562c284aa0e88d29677b909e625 220 SMART SM00421 154 211 2.4E-21 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS28110 572c6562c284aa0e88d29677b909e625 220 Pfam PF00196 Bacterial regulatory proteins, luxR family 156 210 1.7E-14 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS28110 572c6562c284aa0e88d29677b909e625 220 SMART SM00448 6 120 2.4E-27 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS28110 572c6562c284aa0e88d29677b909e625 220 Pfam PF00072 Response regulator receiver domain 8 121 7.3E-28 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS28110 572c6562c284aa0e88d29677b909e625 220 SUPERFAMILY SSF52172 5 179 1.1E-30 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS28110 572c6562c284aa0e88d29677b909e625 220 Gene3D G3DSA:1.10.10.10 135 215 2.3E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS20675 e9c28d6ed3f61ab5674ff7b45f4c0895 290 Gene3D G3DSA:3.90.1200.10 107 257 4.6E-30 T 09-03-2017 TK78_RS20675 e9c28d6ed3f61ab5674ff7b45f4c0895 290 SUPERFAMILY SSF56112 11 258 2.46E-44 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS20675 e9c28d6ed3f61ab5674ff7b45f4c0895 290 Pfam PF01636 Phosphotransferase enzyme family 29 250 3.6E-34 T 09-03-2017 IPR002575 Aminoglycoside phosphotransferase TK78_RS26470 ba2db05bf180e6b93654c9301f17bb9f 356 TIGRFAM TIGR01766 tspaseT_teng_C: transposase, IS605 OrfB family 177 241 5.9E-7 T 09-03-2017 IPR010095 Transposase IS605, OrfB, C-terminal TK78_RS16110 30cdc93842bf2adc922feb3b649e7023 381 Gene3D G3DSA:2.130.10.130 224 351 2.7E-12 T 09-03-2017 TK78_RS16110 30cdc93842bf2adc922feb3b649e7023 381 Gene3D G3DSA:2.130.10.130 78 223 3.1E-14 T 09-03-2017 TK78_RS16110 30cdc93842bf2adc922feb3b649e7023 381 Pfam PF13517 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella 153 228 1.7E-7 T 09-03-2017 TK78_RS16110 30cdc93842bf2adc922feb3b649e7023 381 SUPERFAMILY SSF69318 66 350 9.55E-26 T 09-03-2017 TK78_RS04975 229d0a2edeeb42c6b07d9750438b1e97 462 Pfam PF01979 Amidohydrolase family 65 415 8.8E-62 T 09-03-2017 IPR006680 Amidohydrolase-related GO:0016787 TK78_RS04975 229d0a2edeeb42c6b07d9750438b1e97 462 Gene3D G3DSA:3.20.20.140 70 391 1.5E-106 T 09-03-2017 TK78_RS04975 229d0a2edeeb42c6b07d9750438b1e97 462 SUPERFAMILY SSF51338 341 460 1.59E-25 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS04975 229d0a2edeeb42c6b07d9750438b1e97 462 SUPERFAMILY SSF51338 9 80 1.43E-10 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS04975 229d0a2edeeb42c6b07d9750438b1e97 462 Gene3D G3DSA:2.30.40.10 6 69 7.1E-16 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS04975 229d0a2edeeb42c6b07d9750438b1e97 462 Gene3D G3DSA:2.30.40.10 392 412 7.1E-16 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS04975 229d0a2edeeb42c6b07d9750438b1e97 462 SUPERFAMILY SSF51556 67 382 2.04E-95 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS27550 d432639e6e992c01008bc99bf503d133 146 SUPERFAMILY SSF55874 50 140 3.18E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09915 d9d5a1d87b83dd60a11d96d23016ac68 311 Pfam PF11583 P-aminobenzoate N-oxygenase AurF 21 294 1.5E-98 T 09-03-2017 IPR025859 P-aminobenzoate N-oxygenase AurF TK78_RS09915 d9d5a1d87b83dd60a11d96d23016ac68 311 SUPERFAMILY SSF47240 36 225 2.27E-11 T 09-03-2017 IPR009078 Ferritin-like superfamily TK78_RS16620 d985a092c23e35dc9395b0d47606afee 156 TIGRFAM TIGR03618 Rv1155_F420: PPOX class probable F420-dependent enzyme 17 141 2.9E-38 T 09-03-2017 IPR019920 F420-binding domain, putative TK78_RS16620 d985a092c23e35dc9395b0d47606afee 156 Gene3D G3DSA:2.30.110.10 14 147 1.2E-29 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS16620 d985a092c23e35dc9395b0d47606afee 156 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 14 98 1.5E-14 T 09-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS16620 d985a092c23e35dc9395b0d47606afee 156 SUPERFAMILY SSF50475 14 140 3.75E-30 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS31125 eded2f3da70cd181548ae4524b391b62 409 Pfam PF07690 Major Facilitator Superfamily 50 347 3.5E-13 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS31125 eded2f3da70cd181548ae4524b391b62 409 SUPERFAMILY SSF103473 34 392 1.83E-23 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS31125 eded2f3da70cd181548ae4524b391b62 409 Gene3D G3DSA:1.20.1250.20 47 197 6.0E-9 T 09-03-2017 TK78_RS31125 eded2f3da70cd181548ae4524b391b62 409 Gene3D G3DSA:1.20.1250.20 216 386 1.8E-11 T 09-03-2017 TK78_RS06580 b171a979dd15a2fbef8efdff54cfec35 323 SUPERFAMILY SSF161098 114 303 4.32E-27 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS06580 b171a979dd15a2fbef8efdff54cfec35 323 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 136 318 6.1E-35 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS06580 b171a979dd15a2fbef8efdff54cfec35 323 Gene3D G3DSA:1.10.3720.10 112 318 3.6E-30 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS06580 b171a979dd15a2fbef8efdff54cfec35 323 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C 29 64 1.9E-6 T 09-03-2017 IPR025966 Oligopeptide transport permease C-like, N-terminal domain TK78_RS07305 523c9c9a4b5b0e3bcc397400640980fc 236 SUPERFAMILY SSF53098 17 214 1.97E-55 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS07305 523c9c9a4b5b0e3bcc397400640980fc 236 Gene3D G3DSA:3.30.420.10 22 162 1.1E-39 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS07305 523c9c9a4b5b0e3bcc397400640980fc 236 Hamap MF_00052_B Ribonuclease HII [rnhB]. 22 205 33.37 T 09-03-2017 IPR022898 Ribonuclease HII GO:0004523 TK78_RS07305 523c9c9a4b5b0e3bcc397400640980fc 236 Pfam PF01351 Ribonuclease HII 24 203 3.0E-33 T 09-03-2017 IPR024567 Ribonuclease HII/HIII domain TK78_RS18815 ecef64a467c41239eac365d6728e572f 346 SMART SM00354 3 74 6.7E-26 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS18815 ecef64a467c41239eac365d6728e572f 346 Pfam PF00356 Bacterial regulatory proteins, lacI family 7 51 2.3E-14 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS18815 ecef64a467c41239eac365d6728e572f 346 SUPERFAMILY SSF47413 3 62 1.78E-14 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS18815 ecef64a467c41239eac365d6728e572f 346 Gene3D G3DSA:1.10.260.40 4 63 2.9E-23 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS18815 ecef64a467c41239eac365d6728e572f 346 Gene3D G3DSA:3.40.50.2300 64 172 2.3E-34 T 09-03-2017 TK78_RS18815 ecef64a467c41239eac365d6728e572f 346 Pfam PF13377 Periplasmic binding protein-like domain 171 337 2.9E-29 T 09-03-2017 TK78_RS18815 ecef64a467c41239eac365d6728e572f 346 SUPERFAMILY SSF53822 64 339 1.96E-60 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS18815 ecef64a467c41239eac365d6728e572f 346 Gene3D G3DSA:3.40.50.2300 173 339 4.5E-47 T 09-03-2017 TK78_RS00600 25b4bcbf01257a7d8ec7908b1f80b7d5 330 SUPERFAMILY SSF51430 1 309 3.67E-88 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS00600 25b4bcbf01257a7d8ec7908b1f80b7d5 330 Pfam PF00248 Aldo/keto reductase family 16 307 5.4E-64 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS00600 25b4bcbf01257a7d8ec7908b1f80b7d5 330 Gene3D G3DSA:3.20.20.100 1 320 2.0E-95 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS09920 bf286ae181321f47cc8c8bec5a8b5dbb 258 Gene3D G3DSA:1.10.357.10 11 218 2.1E-31 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS09920 bf286ae181321f47cc8c8bec5a8b5dbb 258 SUPERFAMILY SSF48498 93 200 4.82E-6 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS09920 bf286ae181321f47cc8c8bec5a8b5dbb 258 Pfam PF00440 Bacterial regulatory proteins, tetR family 26 73 9.4E-12 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS09920 bf286ae181321f47cc8c8bec5a8b5dbb 258 SUPERFAMILY SSF46689 20 82 4.89E-12 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS05175 1a8b6b48bc746622ad6ddf8a4437ff49 297 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 116 288 1.3E-24 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS05175 1a8b6b48bc746622ad6ddf8a4437ff49 297 SUPERFAMILY SSF161098 96 281 1.96E-30 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS05175 1a8b6b48bc746622ad6ddf8a4437ff49 297 Gene3D G3DSA:1.10.3720.10 96 288 1.6E-22 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS02275 358ea600ee5990c6ae3d49a5bae892f1 65 Pfam PF13490 Putative zinc-finger 11 42 1.5E-7 T 09-03-2017 IPR027383 Putative zinc-finger TK78_RS08430 b5c86c7947ed62f342b7001e43326ae9 1253 SMART SM00304 419 489 9.0E-6 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS08430 b5c86c7947ed62f342b7001e43326ae9 1253 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 604 710 9.0E-11 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS08430 b5c86c7947ed62f342b7001e43326ae9 1253 Pfam PF08376 Nitrate and nitrite sensing 129 381 5.5E-41 T 09-03-2017 IPR013587 Nitrate/nitrite sensing protein TK78_RS08430 b5c86c7947ed62f342b7001e43326ae9 1253 Gene3D G3DSA:3.30.565.10 568 713 1.6E-16 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS08430 b5c86c7947ed62f342b7001e43326ae9 1253 Pfam PF00672 HAMP domain 401 485 9.0E-19 T 09-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 TK78_RS08430 b5c86c7947ed62f342b7001e43326ae9 1253 SUPERFAMILY SSF55874 592 710 1.7E-18 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS21245 859659b6bac234050d9742cc93a9106e 605 Gene3D G3DSA:3.40.50.300 7 252 1.2E-48 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS21245 859659b6bac234050d9742cc93a9106e 605 ProSitePatterns PS00211 ABC transporters family signature. 131 145 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS21245 859659b6bac234050d9742cc93a9106e 605 Pfam PF00005 ABC transporter 21 159 1.2E-22 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS21245 859659b6bac234050d9742cc93a9106e 605 Pfam PF00005 ABC transporter 307 447 2.4E-20 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS21245 859659b6bac234050d9742cc93a9106e 605 SUPERFAMILY SSF52540 5 208 4.02E-44 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS21245 859659b6bac234050d9742cc93a9106e 605 Gene3D G3DSA:3.40.50.300 289 493 7.0E-41 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS21245 859659b6bac234050d9742cc93a9106e 605 SMART SM00382 315 491 1.1E-10 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS21245 859659b6bac234050d9742cc93a9106e 605 SMART SM00382 30 210 3.4E-10 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS21245 859659b6bac234050d9742cc93a9106e 605 ProSitePatterns PS00211 ABC transporters family signature. 419 433 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS21245 859659b6bac234050d9742cc93a9106e 605 Pfam PF12848 ABC transporter 198 272 9.6E-8 T 09-03-2017 IPR032781 ABC-transporter extension domain TK78_RS21245 859659b6bac234050d9742cc93a9106e 605 SUPERFAMILY SSF52540 295 488 1.54E-39 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS21245 859659b6bac234050d9742cc93a9106e 605 Pfam PF16326 ABC transporter C-terminal domain 539 603 2.4E-10 T 09-03-2017 IPR032524 ABC transporter Uup, C-terminal GO:0003677 TK78_RS25880 8a8a5b803954457cef34da05ae1d604f 226 Gene3D G3DSA:3.90.470.20 41 134 3.2E-15 T 09-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 TK78_RS25880 8a8a5b803954457cef34da05ae1d604f 226 Gene3D G3DSA:3.90.470.20 135 183 2.5E-5 T 09-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 TK78_RS25880 8a8a5b803954457cef34da05ae1d604f 226 SUPERFAMILY SSF56214 129 183 5.76E-8 T 09-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 TK78_RS25880 8a8a5b803954457cef34da05ae1d604f 226 SUPERFAMILY SSF56214 36 122 3.3E-11 T 09-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 TK78_RS25880 8a8a5b803954457cef34da05ae1d604f 226 Pfam PF01648 4'-phosphopantetheinyl transferase superfamily 129 184 6.6E-7 T 09-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 TK78_RS05865 e5bf4452de9c97c3e1e5df627ca89b8a 242 Gene3D G3DSA:3.40.1490.10 152 239 2.1E-16 T 09-03-2017 IPR023476 Peptidyl-tRNA hydrolase II domain MetaCyc: PWY-6308 TK78_RS05865 e5bf4452de9c97c3e1e5df627ca89b8a 242 Pfam PF01981 Peptidyl-tRNA hydrolase PTH2 153 239 9.4E-9 T 09-03-2017 IPR002833 Peptidyl-tRNA hydrolase, PTH2 GO:0004045 MetaCyc: PWY-6308 TK78_RS05865 e5bf4452de9c97c3e1e5df627ca89b8a 242 SUPERFAMILY SSF102462 152 239 1.05E-19 T 09-03-2017 IPR023476 Peptidyl-tRNA hydrolase II domain MetaCyc: PWY-6308 TK78_RS33565 fa094208ff7052c20846d13bd0dab113 312 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 152 180 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS33565 fa094208ff7052c20846d13bd0dab113 312 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 165 184 2.3E-5 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33565 fa094208ff7052c20846d13bd0dab113 312 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 145 153 2.3E-5 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33565 fa094208ff7052c20846d13bd0dab113 312 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 93 104 2.3E-5 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33565 fa094208ff7052c20846d13bd0dab113 312 Pfam PF00106 short chain dehydrogenase 22 207 5.2E-43 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33565 fa094208ff7052c20846d13bd0dab113 312 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 165 184 9.2E-15 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33565 fa094208ff7052c20846d13bd0dab113 312 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 139 155 9.2E-15 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33565 fa094208ff7052c20846d13bd0dab113 312 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 22 39 9.2E-15 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33565 fa094208ff7052c20846d13bd0dab113 312 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 93 104 9.2E-15 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS33565 fa094208ff7052c20846d13bd0dab113 312 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 21 200 8.8E-4 T 09-03-2017 TK78_RS33565 fa094208ff7052c20846d13bd0dab113 312 SUPERFAMILY SSF51735 17 273 3.66E-59 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS33565 fa094208ff7052c20846d13bd0dab113 312 Gene3D G3DSA:3.40.50.720 18 238 3.6E-55 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS13040 0478ad6403b1f0167bc38c632efc622f 37 ProDom PD002101 RIBOSOMAL L36 RIBONUCLEOPROTEIN 50S CHLOROPLAST PLASTID B SUBUNIT DIRECT SEQUENCING 9 37 2.0E-9 T 09-03-2017 TK78_RS13040 0478ad6403b1f0167bc38c632efc622f 37 Hamap MF_00251 50S ribosomal protein L36 [rpmJ]. 1 37 17.021 T 09-03-2017 IPR000473 Ribosomal protein L36 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13040 0478ad6403b1f0167bc38c632efc622f 37 TIGRFAM TIGR01022 rpmJ_bact: ribosomal protein bL36 1 37 9.0E-22 T 09-03-2017 IPR000473 Ribosomal protein L36 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13040 0478ad6403b1f0167bc38c632efc622f 37 Pfam PF00444 Ribosomal protein L36 1 37 4.2E-18 T 09-03-2017 IPR000473 Ribosomal protein L36 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13040 0478ad6403b1f0167bc38c632efc622f 37 ProSitePatterns PS00828 Ribosomal protein L36 signature. 11 36 - T 09-03-2017 IPR000473 Ribosomal protein L36 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS13040 0478ad6403b1f0167bc38c632efc622f 37 SUPERFAMILY SSF57840 1 37 3.53E-16 T 09-03-2017 IPR000473 Ribosomal protein L36 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS09185 af9e24603cde794b34e6072941ebab59 153 Pfam PF04965 Gene 25-like lysozyme 36 124 2.0E-24 T 09-03-2017 IPR007048 GpW/Gp25/anti-adapter protein IraD TK78_RS09185 af9e24603cde794b34e6072941ebab59 153 SUPERFAMILY SSF160719 30 137 1.83E-32 T 09-03-2017 TK78_RS09185 af9e24603cde794b34e6072941ebab59 153 Gene3D G3DSA:3.10.450.40 13 137 2.0E-44 T 09-03-2017 TK78_RS31705 c1f83ced4f8db2228e91c79dd8860a4d 447 SUPERFAMILY SSF81340 21 432 1.44E-37 T 09-03-2017 IPR014743 Chloride channel, core GO:0005216|GO:0055085 Reactome: R-HSA-2672351 TK78_RS31705 c1f83ced4f8db2228e91c79dd8860a4d 447 Gene3D G3DSA:1.10.3080.10 22 432 7.0E-25 T 09-03-2017 IPR014743 Chloride channel, core GO:0005216|GO:0055085 Reactome: R-HSA-2672351 TK78_RS31705 c1f83ced4f8db2228e91c79dd8860a4d 447 PRINTS PR00762 Chloride channel signature 172 191 4.0E-6 T 09-03-2017 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 Reactome: R-HSA-2672351 TK78_RS31705 c1f83ced4f8db2228e91c79dd8860a4d 447 PRINTS PR00762 Chloride channel signature 350 370 4.0E-6 T 09-03-2017 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 Reactome: R-HSA-2672351 TK78_RS31705 c1f83ced4f8db2228e91c79dd8860a4d 447 PRINTS PR00762 Chloride channel signature 374 390 4.0E-6 T 09-03-2017 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 Reactome: R-HSA-2672351 TK78_RS31705 c1f83ced4f8db2228e91c79dd8860a4d 447 PRINTS PR00762 Chloride channel signature 119 138 4.0E-6 T 09-03-2017 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 Reactome: R-HSA-2672351 TK78_RS31705 c1f83ced4f8db2228e91c79dd8860a4d 447 Pfam PF00654 Voltage gated chloride channel 83 429 4.2E-23 T 09-03-2017 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 Reactome: R-HSA-2672351 TK78_RS03185 2d87ad946c2271e143c2c5446ba98561 353 Gene3D G3DSA:1.20.1090.10 159 346 4.3E-60 T 09-03-2017 TK78_RS03185 2d87ad946c2271e143c2c5446ba98561 353 Gene3D G3DSA:3.40.50.1970 8 157 5.0E-27 T 09-03-2017 TK78_RS03185 2d87ad946c2271e143c2c5446ba98561 353 SUPERFAMILY SSF56796 4 344 1.28E-55 T 09-03-2017 TK78_RS03185 2d87ad946c2271e143c2c5446ba98561 353 PIRSF PIRSF000112 2 353 1.8E-94 T 09-03-2017 TK78_RS03185 2d87ad946c2271e143c2c5446ba98561 353 Pfam PF13685 Iron-containing alcohol dehydrogenase 16 270 1.6E-57 T 09-03-2017 IPR032837 Glycerol-1-phosphate dehydrogenase KEGG: 00564+1.1.1.261|KEGG: 00630+1.1.1.26|MetaCyc: PWY-6349|MetaCyc: PWY-7294|MetaCyc: PWY-7295 TK78_RS15580 9f065d874032cfad48c79a1141674c16 270 Gene3D G3DSA:3.40.50.150 74 231 6.5E-40 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS15580 9f065d874032cfad48c79a1141674c16 270 SUPERFAMILY SSF53335 63 232 1.1E-39 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS15580 9f065d874032cfad48c79a1141674c16 270 Pfam PF13847 Methyltransferase domain 76 192 5.6E-28 T 09-03-2017 IPR025714 Methyltransferase domain TK78_RS10235 d98d15a1d173596dc0c68a2a3c86e337 86 Pfam PF02148 Zn-finger in ubiquitin-hydrolases and other protein 33 83 4.1E-12 T 09-03-2017 IPR001607 Zinc finger, UBP-type GO:0008270 TK78_RS10235 d98d15a1d173596dc0c68a2a3c86e337 86 Gene3D G3DSA:3.30.40.10 2 85 8.0E-24 T 09-03-2017 IPR013083 Zinc finger, RING/FYVE/PHD-type TK78_RS10235 d98d15a1d173596dc0c68a2a3c86e337 86 SUPERFAMILY SSF57850 2 85 6.83E-26 T 09-03-2017 TK78_RS30240 c74515288ebb4fa65329046fadc64599 161 Pfam PF03652 Holliday junction resolvase 12 144 1.8E-41 T 09-03-2017 IPR005227 Putative pre-16S rRNA nuclease GO:0006364 TK78_RS30240 c74515288ebb4fa65329046fadc64599 161 Gene3D G3DSA:3.30.420.140 10 150 1.6E-46 T 09-03-2017 IPR006641 YqgF/RNase H-like domain GO:0006139 TK78_RS30240 c74515288ebb4fa65329046fadc64599 161 SMART SM00732 11 112 5.1E-32 T 09-03-2017 IPR006641 YqgF/RNase H-like domain GO:0006139 TK78_RS30240 c74515288ebb4fa65329046fadc64599 161 SUPERFAMILY SSF53098 11 145 1.23E-34 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS30240 c74515288ebb4fa65329046fadc64599 161 TIGRFAM TIGR00250 RNAse_H_YqgF: putative transcription antitermination factor YqgF 14 144 4.3E-30 T 09-03-2017 IPR005227 Putative pre-16S rRNA nuclease GO:0006364 TK78_RS30240 c74515288ebb4fa65329046fadc64599 161 Hamap MF_00651 Putative pre-16S rRNA nuclease [yqgF]. 11 147 22.31 T 09-03-2017 IPR005227 Putative pre-16S rRNA nuclease GO:0006364 TK78_RS31990 9e1433f146e8a153136d5be2905fc90e 235 PRINTS PR00410 Phenol hydroxylase reductase family signature 202 210 2.8E-8 T 09-03-2017 IPR001221 Phenol hydroxylase reductase GO:0055114 TK78_RS31990 9e1433f146e8a153136d5be2905fc90e 235 PRINTS PR00410 Phenol hydroxylase reductase family signature 32 44 2.8E-8 T 09-03-2017 IPR001221 Phenol hydroxylase reductase GO:0055114 TK78_RS31990 9e1433f146e8a153136d5be2905fc90e 235 PRINTS PR00410 Phenol hydroxylase reductase family signature 114 133 2.8E-8 T 09-03-2017 IPR001221 Phenol hydroxylase reductase GO:0055114 TK78_RS31990 9e1433f146e8a153136d5be2905fc90e 235 SUPERFAMILY SSF63380 2 104 1.48E-21 T 09-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 TK78_RS31990 9e1433f146e8a153136d5be2905fc90e 235 Gene3D G3DSA:3.40.50.80 93 230 2.3E-30 T 09-03-2017 TK78_RS31990 9e1433f146e8a153136d5be2905fc90e 235 Pfam PF00970 Oxidoreductase FAD-binding domain 7 102 9.6E-13 T 09-03-2017 IPR008333 Oxidoreductase, FAD-binding domain Reactome: R-HSA-1237044 TK78_RS31990 9e1433f146e8a153136d5be2905fc90e 235 Gene3D G3DSA:2.40.30.10 2 92 6.0E-21 T 09-03-2017 TK78_RS31990 9e1433f146e8a153136d5be2905fc90e 235 SUPERFAMILY SSF52343 93 232 2.62E-29 T 09-03-2017 TK78_RS31990 9e1433f146e8a153136d5be2905fc90e 235 Pfam PF00175 Oxidoreductase NAD-binding domain 115 215 1.5E-11 T 09-03-2017 IPR001433 Oxidoreductase FAD/NAD(P)-binding GO:0016491|GO:0055114 TK78_RS26815 6615e14bc8fd39ae9b52832f82dbfa03 251 SUPERFAMILY SSF144091 25 233 1.7E-37 T 09-03-2017 TK78_RS26815 6615e14bc8fd39ae9b52832f82dbfa03 251 Gene3D G3DSA:1.20.1540.10 26 230 7.4E-37 T 09-03-2017 IPR022764 Peptidase S54, rhomboid domain GO:0004252|GO:0016021 TK78_RS26815 6615e14bc8fd39ae9b52832f82dbfa03 251 Pfam PF01694 Rhomboid family 82 233 1.6E-36 T 09-03-2017 IPR022764 Peptidase S54, rhomboid domain GO:0004252|GO:0016021 TK78_RS05665 70f649107b2eba92aa28e3033a9bc894 303 SUPERFAMILY SSF55729 135 298 7.09E-15 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS05665 70f649107b2eba92aa28e3033a9bc894 303 Gene3D G3DSA:3.40.630.30 167 299 9.4E-12 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS05665 70f649107b2eba92aa28e3033a9bc894 303 Pfam PF00583 Acetyltransferase (GNAT) family 221 293 7.6E-5 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS20990 416cadad540e31498c3ad54440686e8c 271 TIGRFAM TIGR00633 xth: exodeoxyribonuclease III (xth) 4 269 2.6E-71 T 09-03-2017 IPR004808 AP endonuclease 1 GO:0004518|GO:0006281 TK78_RS20990 416cadad540e31498c3ad54440686e8c 271 Gene3D G3DSA:3.60.10.10 1 270 2.8E-89 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS20990 416cadad540e31498c3ad54440686e8c 271 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 6 262 2.4E-27 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS20990 416cadad540e31498c3ad54440686e8c 271 TIGRFAM TIGR00195 exoDNase_III: exodeoxyribonuclease III 4 268 2.3E-69 T 09-03-2017 TK78_RS20990 416cadad540e31498c3ad54440686e8c 271 SUPERFAMILY SSF56219 2 269 2.09E-70 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS31760 e6593ea52b9892a650b8c0111ffb7b20 593 SMART SM00382 381 567 6.4E-15 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS31760 e6593ea52b9892a650b8c0111ffb7b20 593 SUPERFAMILY SSF52540 352 591 3.58E-68 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31760 e6593ea52b9892a650b8c0111ffb7b20 593 Gene3D G3DSA:3.40.50.300 357 585 3.4E-61 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31760 e6593ea52b9892a650b8c0111ffb7b20 593 SUPERFAMILY SSF90123 33 346 1.44E-52 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS31760 e6593ea52b9892a650b8c0111ffb7b20 593 Pfam PF00005 ABC transporter 372 521 3.1E-25 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS31760 e6593ea52b9892a650b8c0111ffb7b20 593 Gene3D G3DSA:1.20.1560.10 33 342 3.8E-51 T 09-03-2017 TK78_RS31760 e6593ea52b9892a650b8c0111ffb7b20 593 Pfam PF00664 ABC transporter transmembrane region 44 312 4.6E-28 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS21735 4a461638142a50cae3f6881246a7858a 455 SUPERFAMILY SSF51556 63 377 6.41E-70 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS21735 4a461638142a50cae3f6881246a7858a 455 TIGRFAM TIGR02022 hutF: formiminoglutamate deiminase 14 454 3.2E-165 T 09-03-2017 IPR010252 Formiminoglutamate deiminase TK78_RS21735 4a461638142a50cae3f6881246a7858a 455 Pfam PF01979 Amidohydrolase family 62 428 2.4E-44 T 09-03-2017 IPR006680 Amidohydrolase-related GO:0016787 TK78_RS21735 4a461638142a50cae3f6881246a7858a 455 Gene3D G3DSA:3.20.20.140 66 397 4.5E-79 T 09-03-2017 TK78_RS21735 4a461638142a50cae3f6881246a7858a 455 SUPERFAMILY SSF51338 339 451 5.25E-13 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS27120 c27532db35f52096cb99e39b6196022d 240 TIGRFAM TIGR00726 TIGR00726: YfiH family protein 17 238 2.1E-43 T 09-03-2017 IPR003730 Multi-copper polyphenol oxidoreductase, laccase TK78_RS27120 c27532db35f52096cb99e39b6196022d 240 Pfam PF02578 Multi-copper polyphenol oxidoreductase laccase 12 237 3.2E-68 T 09-03-2017 IPR003730 Multi-copper polyphenol oxidoreductase, laccase TK78_RS27120 c27532db35f52096cb99e39b6196022d 240 Gene3D G3DSA:3.60.140.10 7 239 1.3E-81 T 09-03-2017 IPR003730 Multi-copper polyphenol oxidoreductase, laccase TK78_RS27120 c27532db35f52096cb99e39b6196022d 240 SUPERFAMILY SSF64438 5 239 8.06E-73 T 09-03-2017 IPR011324 Cytotoxic necrotizing factor-like, catalytic TK78_RS07180 4a4801167340ca42454cfb41c454aee8 93 ProSitePatterns PS00369 PTS HPR domain histidine phosphorylation site signature. 13 20 - T 09-03-2017 IPR001020 Phosphotransferase system, HPr histidine phosphorylation site TK78_RS07180 4a4801167340ca42454cfb41c454aee8 93 Gene3D G3DSA:3.30.1340.10 1 88 6.6E-25 T 09-03-2017 IPR000032 Phosphocarrier protein HPr-like TK78_RS07180 4a4801167340ca42454cfb41c454aee8 93 Pfam PF00381 PTS HPr component phosphorylation site 3 83 2.7E-22 T 09-03-2017 IPR000032 Phosphocarrier protein HPr-like TK78_RS07180 4a4801167340ca42454cfb41c454aee8 93 TIGRFAM TIGR01003 PTS_HPr_family: phosphocarrier, HPr family 1 82 1.4E-25 T 09-03-2017 IPR000032 Phosphocarrier protein HPr-like TK78_RS07180 4a4801167340ca42454cfb41c454aee8 93 PRINTS PR00107 Phosphocarrier protein signature 13 29 1.6E-11 T 09-03-2017 IPR000032 Phosphocarrier protein HPr-like TK78_RS07180 4a4801167340ca42454cfb41c454aee8 93 PRINTS PR00107 Phosphocarrier protein signature 39 54 1.6E-11 T 09-03-2017 IPR000032 Phosphocarrier protein HPr-like TK78_RS07180 4a4801167340ca42454cfb41c454aee8 93 PRINTS PR00107 Phosphocarrier protein signature 54 71 1.6E-11 T 09-03-2017 IPR000032 Phosphocarrier protein HPr-like TK78_RS07180 4a4801167340ca42454cfb41c454aee8 93 SUPERFAMILY SSF55594 1 88 1.07E-19 T 09-03-2017 IPR000032 Phosphocarrier protein HPr-like TK78_RS34130 4fe081eb3c113f9aa1a55f18451b386b 266 Gene3D G3DSA:3.90.226.10 4 264 1.7E-80 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS34130 4fe081eb3c113f9aa1a55f18451b386b 266 SUPERFAMILY SSF52096 4 264 9.96E-81 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS34130 4fe081eb3c113f9aa1a55f18451b386b 266 Pfam PF00378 Enoyl-CoA hydratase/isomerase 13 264 7.2E-54 T 09-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 TK78_RS33555 3324d769f61cc520d1a906ad91bd5b47 245 Gene3D G3DSA:3.10.180.10 2 123 4.4E-13 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS33555 3324d769f61cc520d1a906ad91bd5b47 245 Gene3D G3DSA:3.10.180.10 133 244 4.4E-8 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS33555 3324d769f61cc520d1a906ad91bd5b47 245 SUPERFAMILY SSF54593 1 125 2.82E-13 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS33555 3324d769f61cc520d1a906ad91bd5b47 245 SUPERFAMILY SSF54593 132 244 2.82E-13 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS26990 7d4cf0cb9088cb4eec298e35da29561b 305 SUPERFAMILY SSF51730 15 301 1.9E-93 T 09-03-2017 IPR029041 FAD-linked oxidoreductase-like TK78_RS26990 7d4cf0cb9088cb4eec298e35da29561b 305 TIGRFAM TIGR00676 fadh2: methylenetetrahydrofolate reductase [NAD(P)H] 27 299 1.4E-95 T 09-03-2017 IPR004620 5,10-methylenetetrahydrofolate reductase GO:0004489|GO:0005829|GO:0009086|GO:0055114 KEGG: 00670+1.5.1.20|KEGG: 00720+1.5.1.20|MetaCyc: PWY-2201|MetaCyc: PWY-3841 TK78_RS26990 7d4cf0cb9088cb4eec298e35da29561b 305 Gene3D G3DSA:3.20.20.220 11 303 1.5E-104 T 09-03-2017 IPR029041 FAD-linked oxidoreductase-like TK78_RS26990 7d4cf0cb9088cb4eec298e35da29561b 305 Pfam PF02219 Methylenetetrahydrofolate reductase 16 300 2.1E-108 T 09-03-2017 IPR003171 Methylenetetrahydrofolate reductase GO:0004489|GO:0006555|GO:0055114 KEGG: 00670+1.5.1.20|KEGG: 00720+1.5.1.20|MetaCyc: PWY-2201|MetaCyc: PWY-3841|Reactome: R-HSA-196757 TK78_RS21220 4a31f636a756a3bf0841eb03cb224ce8 50 Pfam PF06769 YoeB-like toxin of bacterial type II toxin-antitoxin system 4 48 5.1E-17 T 09-03-2017 IPR009614 Toxin YoeB GO:0004519|GO:0006401 TK78_RS21220 4a31f636a756a3bf0841eb03cb224ce8 50 TIGRFAM TIGR02116 toxin_Txe_YoeB: addiction module toxin, Txe/YoeB family 4 48 4.2E-16 T 09-03-2017 IPR009614 Toxin YoeB GO:0004519|GO:0006401 TK78_RS21220 4a31f636a756a3bf0841eb03cb224ce8 50 SUPERFAMILY SSF143011 4 47 3.92E-12 T 09-03-2017 TK78_RS07475 74a3cc3bef8ead10eeddb264fc5296e8 193 SUPERFAMILY SSF51182 31 177 5.53E-26 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS07475 74a3cc3bef8ead10eeddb264fc5296e8 193 Pfam PF05995 Cysteine dioxygenase type I 25 176 5.7E-44 T 09-03-2017 IPR010300 Cysteine dioxygenase type I GO:0005506|GO:0016702|GO:0055114 KEGG: 00270+1.13.11.20|KEGG: 00430+1.13.11.20|MetaCyc: PWY-5331|Reactome: R-HSA-1614558 TK78_RS07475 74a3cc3bef8ead10eeddb264fc5296e8 193 Gene3D G3DSA:2.60.120.10 56 178 7.8E-16 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS02945 8ed131343f466b11107a6cae30773066 129 SUPERFAMILY SSF142906 7 117 2.35E-19 T 09-03-2017 TK78_RS02945 8ed131343f466b11107a6cae30773066 129 Pfam PF04237 YjbR 17 105 2.6E-18 T 09-03-2017 IPR007351 Uncharacterised protein YjbR TK78_RS02635 076bbc40cf2d5079be41285b7487bd91 313 Pfam PF04116 Fatty acid hydroxylase superfamily 138 268 1.8E-24 T 09-03-2017 IPR006694 Fatty acid hydroxylase GO:0005506|GO:0006633|GO:0016491|GO:0055114 TK78_RS24930 5ec1a1f74ceca182110902dae1e7cfae 280 SMART SM00530 11 83 1.2E-7 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS24930 5ec1a1f74ceca182110902dae1e7cfae 280 SUPERFAMILY SSF47413 30 82 9.38E-7 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS24930 5ec1a1f74ceca182110902dae1e7cfae 280 Gene3D G3DSA:1.10.260.40 6 82 2.1E-15 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS24930 5ec1a1f74ceca182110902dae1e7cfae 280 Pfam PF13560 Helix-turn-helix domain 8 86 5.1E-15 T 09-03-2017 TK78_RS15230 d358ec85bd65abaae18476b6e8c00d6a 214 SUPERFAMILY SSF46894 138 210 6.12E-21 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS15230 d358ec85bd65abaae18476b6e8c00d6a 214 Gene3D G3DSA:1.10.10.10 148 208 1.1E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS15230 d358ec85bd65abaae18476b6e8c00d6a 214 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 149 163 6.3E-12 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS15230 d358ec85bd65abaae18476b6e8c00d6a 214 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 179 191 6.3E-12 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS15230 d358ec85bd65abaae18476b6e8c00d6a 214 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 163 179 6.3E-12 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS15230 d358ec85bd65abaae18476b6e8c00d6a 214 ProSitePatterns PS00622 LuxR-type HTH domain signature. 163 190 - T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS15230 d358ec85bd65abaae18476b6e8c00d6a 214 Pfam PF00072 Response regulator receiver domain 1 111 7.2E-30 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS15230 d358ec85bd65abaae18476b6e8c00d6a 214 SUPERFAMILY SSF52172 1 129 2.7E-34 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS15230 d358ec85bd65abaae18476b6e8c00d6a 214 Gene3D G3DSA:3.40.50.2300 1 147 7.5E-40 T 09-03-2017 TK78_RS15230 d358ec85bd65abaae18476b6e8c00d6a 214 SMART SM00421 146 203 4.9E-23 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS15230 d358ec85bd65abaae18476b6e8c00d6a 214 SMART SM00448 1 112 3.1E-30 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS15230 d358ec85bd65abaae18476b6e8c00d6a 214 Pfam PF00196 Bacterial regulatory proteins, luxR family 148 202 1.4E-17 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS16950 104dbddbc7fdc2643e605ede8af53ce9 479 SMART SM00331 259 478 1.3E-13 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS16950 104dbddbc7fdc2643e605ede8af53ce9 479 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 285 479 1.5E-34 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS16950 104dbddbc7fdc2643e605ede8af53ce9 479 Gene3D G3DSA:3.30.450.40 69 201 2.8E-5 T 09-03-2017 IPR029016 GAF domain-like TK78_RS12760 f23b49012581bc77bce64c570dc41052 442 Gene3D G3DSA:3.40.190.10 41 166 4.5E-20 T 09-03-2017 TK78_RS12760 f23b49012581bc77bce64c570dc41052 442 Pfam PF01547 Bacterial extracellular solute-binding protein 50 336 2.7E-36 T 09-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 TK78_RS12760 f23b49012581bc77bce64c570dc41052 442 Gene3D G3DSA:3.40.190.10 167 339 5.3E-33 T 09-03-2017 TK78_RS12760 f23b49012581bc77bce64c570dc41052 442 SUPERFAMILY SSF53850 41 425 3.97E-61 T 09-03-2017 TK78_RS20265 7a65079dce2efd63e2ed69a588e1977a 306 TIGRFAM TIGR01475 ubiA_other: putative 4-hydroxybenzoate polyprenyltransferase 19 299 1.5E-89 T 09-03-2017 IPR006371 4-hydroxybenzoate polyprenyltransferase-related TK78_RS20265 7a65079dce2efd63e2ed69a588e1977a 306 Pfam PF01040 UbiA prenyltransferase family 42 281 2.5E-50 T 09-03-2017 IPR000537 UbiA prenyltransferase family GO:0004659|GO:0016021 TK78_RS33430 f256d88db42019cc487f9a061a2d9031 136 Pfam PF03610 PTS system fructose IIA component 8 123 2.5E-23 T 09-03-2017 IPR004701 Phosphotransferase system, mannose-type IIA component GO:0009401|GO:0016021 TK78_RS33430 f256d88db42019cc487f9a061a2d9031 136 Gene3D G3DSA:3.40.50.510 3 135 4.9E-41 T 09-03-2017 IPR004701 Phosphotransferase system, mannose-type IIA component GO:0009401|GO:0016021 TK78_RS33430 f256d88db42019cc487f9a061a2d9031 136 SUPERFAMILY SSF53062 7 133 4.97E-26 T 09-03-2017 IPR004701 Phosphotransferase system, mannose-type IIA component GO:0009401|GO:0016021 TK78_RS11175 aad31ff46a4a7fdc9768913326125d6d 336 Gene3D G3DSA:3.40.50.620 159 295 3.7E-24 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS11175 aad31ff46a4a7fdc9768913326125d6d 336 Pfam PF02698 DUF218 domain 160 308 6.4E-26 T 09-03-2017 IPR003848 Domain of unknown function DUF218 TK78_RS22225 a1042a773ae751e776b62d66078bf31e 454 Pfam PF13416 Bacterial extracellular solute-binding protein 75 384 1.9E-19 T 09-03-2017 TK78_RS22225 a1042a773ae751e776b62d66078bf31e 454 SUPERFAMILY SSF53850 55 450 1.38E-50 T 09-03-2017 TK78_RS22225 a1042a773ae751e776b62d66078bf31e 454 Gene3D G3DSA:3.40.190.10 186 378 3.0E-26 T 09-03-2017 TK78_RS22225 a1042a773ae751e776b62d66078bf31e 454 Gene3D G3DSA:3.40.190.10 64 185 3.8E-18 T 09-03-2017 TK78_RS12470 3382d854441c9e88c01a920410b90ef9 224 Pfam PF11222 Protein of unknown function (DUF3017) 128 202 3.1E-20 T 09-03-2017 IPR021385 Protein of unknown function DUF3017 TK78_RS21975 a9d919b830cdff75213893f0e020807c 1294 SUPERFAMILY SSF53448 139 276 1.69E-31 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS21975 a9d919b830cdff75213893f0e020807c 1294 SUPERFAMILY SSF53448 23 100 1.69E-31 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS21975 a9d919b830cdff75213893f0e020807c 1294 Pfam PF13641 Glycosyltransferase like family 2 36 275 8.4E-17 T 09-03-2017 TK78_RS21975 a9d919b830cdff75213893f0e020807c 1294 Gene3D G3DSA:3.90.550.10 24 104 9.1E-29 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS21975 a9d919b830cdff75213893f0e020807c 1294 Gene3D G3DSA:3.90.550.10 140 276 9.1E-29 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS18695 dd3a5f3e215b02e17dfa06b788cb6eb0 307 Pfam PF00583 Acetyltransferase (GNAT) family 217 295 8.5E-13 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS18695 dd3a5f3e215b02e17dfa06b788cb6eb0 307 Pfam PF00583 Acetyltransferase (GNAT) family 67 136 6.4E-5 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS18695 dd3a5f3e215b02e17dfa06b788cb6eb0 307 PIRSF PIRSF021524 9 307 9.7E-109 T 09-03-2017 IPR017813 Mycothiol acetyltransferase GO:0016747 TK78_RS18695 dd3a5f3e215b02e17dfa06b788cb6eb0 307 Gene3D G3DSA:3.40.630.30 20 136 4.7E-11 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS18695 dd3a5f3e215b02e17dfa06b788cb6eb0 307 Gene3D G3DSA:3.40.630.30 163 303 2.2E-31 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS18695 dd3a5f3e215b02e17dfa06b788cb6eb0 307 SUPERFAMILY SSF55729 18 302 5.43E-49 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS18695 dd3a5f3e215b02e17dfa06b788cb6eb0 307 Hamap MF_01698 Mycothiol acetyltransferase [mshD]. 14 305 35.886 T 09-03-2017 IPR017813 Mycothiol acetyltransferase GO:0016747 TK78_RS18695 dd3a5f3e215b02e17dfa06b788cb6eb0 307 TIGRFAM TIGR03448 mycothiol_MshD: mycothiol synthase 18 303 6.8E-116 T 09-03-2017 IPR017813 Mycothiol acetyltransferase GO:0016747 TK78_RS23200 5c871caefca56ffe3a6000901f8800fc 440 Gene3D G3DSA:3.40.190.10 64 176 5.9E-7 T 09-03-2017 TK78_RS23200 5c871caefca56ffe3a6000901f8800fc 440 SUPERFAMILY SSF53850 46 438 2.64E-48 T 09-03-2017 TK78_RS23200 5c871caefca56ffe3a6000901f8800fc 440 Pfam PF13416 Bacterial extracellular solute-binding protein 65 373 3.2E-30 T 09-03-2017 TK78_RS23200 5c871caefca56ffe3a6000901f8800fc 440 Gene3D G3DSA:3.40.190.10 177 368 5.9E-25 T 09-03-2017 TK78_RS21045 4eb2e5b7c33524afd012dde5bd1b2596 353 Pfam PF13190 PDGLE domain 254 332 8.5E-16 T 09-03-2017 IPR025937 PDGLE domain TK78_RS21045 4eb2e5b7c33524afd012dde5bd1b2596 353 Pfam PF01891 Cobalt uptake substrate-specific transmembrane region 2 208 9.2E-61 T 09-03-2017 IPR002751 Cobalamin (vitamin B12) biosynthesis CbiM family GO:0000041|GO:0016021 TK78_RS21045 4eb2e5b7c33524afd012dde5bd1b2596 353 ProDom PD486863 PRECURSOR CBIM SIGNAL COBALT MEMBRANE VITAMIN B12 BIOSYNTHESIS COBALAMIN ABC-TYPE 251 314 2.0E-22 T 09-03-2017 TK78_RS27385 d54f59a5e775e4b128922f0fb7cc8d8f 483 SUPERFAMILY SSF101478 135 456 6.15E-42 T 09-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 TK78_RS27385 d54f59a5e775e4b128922f0fb7cc8d8f 483 Pfam PF03747 ADP-ribosylglycohydrolase 139 447 2.8E-59 T 09-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 TK78_RS25635 41bab4b22984fe200aba342354f1baf7 405 Gene3D G3DSA:3.20.20.60 36 332 4.2E-40 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS25635 41bab4b22984fe200aba342354f1baf7 405 Pfam PF15617 C-C_Bond_Lyase of the TIM-Barrel fold 31 388 2.1E-131 T 09-03-2017 TK78_RS25635 41bab4b22984fe200aba342354f1baf7 405 SUPERFAMILY SSF51621 35 268 3.3E-24 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS25635 41bab4b22984fe200aba342354f1baf7 405 SUPERFAMILY SSF51621 299 332 3.3E-24 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS15170 ce3e2c01b3d8b530feb8d8fc93643656 429 Gene3D G3DSA:3.50.50.60 89 225 1.4E-12 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS15170 ce3e2c01b3d8b530feb8d8fc93643656 429 Pfam PF13434 L-lysine 6-monooxygenase (NADPH-requiring) 6 337 2.2E-123 T 09-03-2017 IPR025700 L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase TK78_RS15170 ce3e2c01b3d8b530feb8d8fc93643656 429 SUPERFAMILY SSF51905 5 264 8.64E-22 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS11625 5e723810448f43e520305797af2a8ddc 445 Pfam PF00437 Type II/IV secretion system protein 86 362 8.9E-89 T 09-03-2017 IPR001482 Type II secretion system protein E GO:0005524|GO:0006810 TK78_RS11625 5e723810448f43e520305797af2a8ddc 445 Gene3D G3DSA:3.30.450.90 83 180 4.2E-38 T 09-03-2017 TK78_RS11625 5e723810448f43e520305797af2a8ddc 445 Gene3D G3DSA:3.40.50.300 184 397 3.9E-59 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS11625 5e723810448f43e520305797af2a8ddc 445 SUPERFAMILY SSF52540 69 399 2.24E-56 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23835 67a2f098f4669a33c8132270a09494b5 217 SMART SM00701 38 193 1.6E-7 T 09-03-2017 IPR006619 Peptidoglycan recognition protein family domain, metazoa/bacteria GO:0008270|GO:0008745|GO:0009253 TK78_RS23835 67a2f098f4669a33c8132270a09494b5 217 SMART SM00644 50 199 1.0E-9 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS23835 67a2f098f4669a33c8132270a09494b5 217 Pfam PF01510 N-acetylmuramoyl-L-alanine amidase 60 199 9.2E-17 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS23835 67a2f098f4669a33c8132270a09494b5 217 Gene3D G3DSA:3.40.80.10 36 214 6.3E-41 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS23835 67a2f098f4669a33c8132270a09494b5 217 SUPERFAMILY SSF55846 39 204 9.95E-40 T 09-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 TK78_RS26975 142d37b721ef2eff63071bc39e1005ea 411 Gene3D G3DSA:3.30.390.30 326 409 4.0E-30 T 09-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 TK78_RS26975 142d37b721ef2eff63071bc39e1005ea 411 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 13 309 3.8E-55 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS26975 142d37b721ef2eff63071bc39e1005ea 411 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 232 253 2.6E-14 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS26975 142d37b721ef2eff63071bc39e1005ea 411 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 13 35 2.6E-14 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS26975 142d37b721ef2eff63071bc39e1005ea 411 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 145 169 2.6E-14 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS26975 142d37b721ef2eff63071bc39e1005ea 411 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 106 114 2.6E-14 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS26975 142d37b721ef2eff63071bc39e1005ea 411 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 267 285 2.6E-14 T 09-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TK78_RS26975 142d37b721ef2eff63071bc39e1005ea 411 Gene3D G3DSA:3.50.50.60 9 110 3.4E-27 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS26975 142d37b721ef2eff63071bc39e1005ea 411 SUPERFAMILY SSF51905 10 284 3.48E-39 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS26975 142d37b721ef2eff63071bc39e1005ea 411 Pfam PF14759 Reductase C-terminal 326 409 7.5E-27 T 09-03-2017 IPR028202 Reductase, C-terminal TK78_RS26975 142d37b721ef2eff63071bc39e1005ea 411 Gene3D G3DSA:3.50.50.60 111 310 2.6E-46 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS26975 142d37b721ef2eff63071bc39e1005ea 411 SUPERFAMILY SSF55424 321 409 3.02E-27 T 09-03-2017 IPR016156 FAD/NAD-linked reductase, dimerisation domain GO:0016491|GO:0050660|GO:0055114 TK78_RS26975 142d37b721ef2eff63071bc39e1005ea 411 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 149 167 1.6E-27 T 09-03-2017 TK78_RS26975 142d37b721ef2eff63071bc39e1005ea 411 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 14 33 1.6E-27 T 09-03-2017 TK78_RS26975 142d37b721ef2eff63071bc39e1005ea 411 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 105 123 1.6E-27 T 09-03-2017 TK78_RS26975 142d37b721ef2eff63071bc39e1005ea 411 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 230 246 1.6E-27 T 09-03-2017 TK78_RS26975 142d37b721ef2eff63071bc39e1005ea 411 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 257 279 1.6E-27 T 09-03-2017 TK78_RS27370 cb10fe889450e402cf2556971db01cee 278 SUPERFAMILY SSF51621 11 228 2.62E-50 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS27370 cb10fe889450e402cf2556971db01cee 278 Pfam PF03328 HpcH/HpaI aldolase/citrate lyase family 16 218 1.8E-26 T 09-03-2017 IPR005000 HpcH/HpaI aldolase/citrate lyase domain GO:0003824 TK78_RS27370 cb10fe889450e402cf2556971db01cee 278 PIRSF PIRSF015582 3 278 1.0E-64 T 09-03-2017 IPR011206 Citrate lyase beta subunit-like TK78_RS27370 cb10fe889450e402cf2556971db01cee 278 Gene3D G3DSA:3.20.20.60 11 230 2.6E-62 T 09-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 TK78_RS03115 f1c511981a28a25323d253138b34117f 270 Pfam PF13350 Tyrosine phosphatase family 15 267 7.1E-58 T 09-03-2017 IPR026893 Tyrosine/serine-protein phosphatase IphP-type TK78_RS03115 f1c511981a28a25323d253138b34117f 270 SUPERFAMILY SSF52799 16 267 8.84E-45 T 09-03-2017 IPR029021 Protein-tyrosine phosphatase-like TK78_RS03115 f1c511981a28a25323d253138b34117f 270 Gene3D G3DSA:3.90.190.10 16 100 9.6E-17 T 09-03-2017 IPR029021 Protein-tyrosine phosphatase-like TK78_RS03115 f1c511981a28a25323d253138b34117f 270 Gene3D G3DSA:3.90.190.10 135 193 9.6E-17 T 09-03-2017 IPR029021 Protein-tyrosine phosphatase-like TK78_RS25610 1dc5cfe1f1da8b0fb7498fc4147f29a6 191 Pfam PF02342 TerD domain 3 187 8.8E-84 T 09-03-2017 IPR003325 TerD domain GO:0006950 TK78_RS25610 1dc5cfe1f1da8b0fb7498fc4147f29a6 191 Gene3D G3DSA:2.60.60.30 18 185 1.6E-73 T 09-03-2017 TK78_RS32315 cacd85d84d600508e7fc3494f3807d5a 158 SUPERFAMILY SSF52091 10 107 3.53E-6 T 09-03-2017 IPR002645 STAS domain TK78_RS32315 cacd85d84d600508e7fc3494f3807d5a 158 Gene3D G3DSA:3.30.750.24 5 107 1.2E-8 T 09-03-2017 IPR002645 STAS domain TK78_RS02060 9a5bdbf9d53178a1d88dd3d35732710c 292 Gene3D G3DSA:3.40.50.150 35 262 3.3E-34 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS02060 9a5bdbf9d53178a1d88dd3d35732710c 292 Pfam PF13649 Methyltransferase domain 57 159 2.5E-8 T 09-03-2017 TK78_RS02060 9a5bdbf9d53178a1d88dd3d35732710c 292 SUPERFAMILY SSF53335 30 222 2.25E-22 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS20270 438abdc230417428f7a09b0932eeb554 210 SUPERFAMILY SSF144091 27 200 2.22E-29 T 09-03-2017 TK78_RS20270 438abdc230417428f7a09b0932eeb554 210 Gene3D G3DSA:1.20.1540.10 35 197 2.6E-21 T 09-03-2017 IPR022764 Peptidase S54, rhomboid domain GO:0004252|GO:0016021 TK78_RS20270 438abdc230417428f7a09b0932eeb554 210 Pfam PF01694 Rhomboid family 61 197 2.5E-27 T 09-03-2017 IPR022764 Peptidase S54, rhomboid domain GO:0004252|GO:0016021 TK78_RS00410 793077656e0afd8a5ceb67f284d98b4d 216 SUPERFAMILY SSF53254 1 199 4.44E-54 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS00410 793077656e0afd8a5ceb67f284d98b4d 216 SMART SM00855 4 158 1.5E-21 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS00410 793077656e0afd8a5ceb67f284d98b4d 216 Gene3D G3DSA:3.40.50.1240 1 198 2.2E-54 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS00410 793077656e0afd8a5ceb67f284d98b4d 216 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 5 198 2.8E-54 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS32955 cbfedb828b627a82d2e07011cd566b31 340 Gene3D G3DSA:3.40.50.720 7 147 1.7E-46 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS32955 cbfedb828b627a82d2e07011cd566b31 340 Gene3D G3DSA:3.30.360.10 148 334 5.4E-32 T 09-03-2017 TK78_RS32955 cbfedb828b627a82d2e07011cd566b31 340 SUPERFAMILY SSF51735 7 155 4.41E-46 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS32955 cbfedb828b627a82d2e07011cd566b31 340 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 10 128 4.5E-27 T 09-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 TK78_RS32955 cbfedb828b627a82d2e07011cd566b31 340 SUPERFAMILY SSF55347 133 278 1.34E-19 T 09-03-2017 TK78_RS06640 770c9dd1c7ab11dd4b34e92f55ef9cdb 385 SUPERFAMILY SSF55909 47 383 2.94E-97 T 09-03-2017 TK78_RS06640 770c9dd1c7ab11dd4b34e92f55ef9cdb 385 Gene3D G3DSA:3.75.10.10 46 384 3.8E-105 T 09-03-2017 TK78_RS06640 770c9dd1c7ab11dd4b34e92f55ef9cdb 385 Pfam PF04371 Porphyromonas-type peptidyl-arginine deiminase 54 383 3.6E-94 T 09-03-2017 IPR007466 Peptidyl-arginine deiminase, Porphyromonas-type GO:0004668|GO:0009446 KEGG: 00330+3.5.3.12|MetaCyc: PWY-43 TK78_RS01530 3608f7b0378c17e6a3e9a988105f252b 568 Pfam PF00881 Nitroreductase family 461 556 2.2E-8 T 09-03-2017 IPR029479 Nitroreductase Reactome: R-HSA-209968 TK78_RS01530 3608f7b0378c17e6a3e9a988105f252b 568 TIGRFAM TIGR03891 thiopep_ocin: thiopeptide-type bacteriocin biosynthesis domain 8 286 5.9E-31 T 09-03-2017 IPR023809 Thiopeptide-type bacteriocin biosynthesis domain TK78_RS01530 3608f7b0378c17e6a3e9a988105f252b 568 SUPERFAMILY SSF55469 476 558 1.07E-12 T 09-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TK78_RS01530 3608f7b0378c17e6a3e9a988105f252b 568 Pfam PF14028 Lantibiotic biosynthesis dehydratase C-term 8 287 7.2E-48 T 09-03-2017 IPR023809 Thiopeptide-type bacteriocin biosynthesis domain TK78_RS01530 3608f7b0378c17e6a3e9a988105f252b 568 Gene3D G3DSA:3.40.109.10 478 556 9.8E-10 T 09-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TK78_RS20500 236a25e5858c9693157caea7430e857f 521 Gene3D G3DSA:3.20.20.140 191 371 2.1E-14 T 09-03-2017 TK78_RS20500 236a25e5858c9693157caea7430e857f 521 SUPERFAMILY SSF89550 191 404 7.85E-33 T 09-03-2017 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 TK78_RS20500 236a25e5858c9693157caea7430e857f 521 SMART SM00481 194 258 8.5E-4 T 09-03-2017 IPR003141 Polymerase/histidinol phosphatase, N-terminal GO:0003677|GO:0003887|GO:0006260 TK78_RS22580 b51ae666e22558e72917f857d8671db4 442 Gene3D G3DSA:3.20.140.10 14 379 5.2E-89 T 09-03-2017 TK78_RS22580 b51ae666e22558e72917f857d8671db4 442 SUPERFAMILY SSF54675 13 144 9.94E-45 T 09-03-2017 TK78_RS22580 b51ae666e22558e72917f857d8671db4 442 SUPERFAMILY SSF51690 146 438 2.8E-77 T 09-03-2017 IPR002638 Quinolinate phosphoribosyl transferase, C-terminal GO:0004514|GO:0009435 KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381 TK78_RS22580 b51ae666e22558e72917f857d8671db4 442 PIRSF PIRSF000484 11 439 5.9E-100 T 09-03-2017 IPR007229 Nicotinate phosphoribosyltransferase family KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381|Reactome: R-HSA-197264 TK78_RS22580 b51ae666e22558e72917f857d8671db4 442 TIGRFAM TIGR01513 NAPRTase_put: nicotinate phosphoribosyltransferase 16 382 8.7E-127 T 09-03-2017 IPR006405 Nicotinate phosphoribosyltransferase pncB-type GO:0004516|GO:0019358 KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381|Reactome: R-HSA-197264 TK78_RS33760 a74f530a7d386cc08c8fdda696f7cb48 558 ProSitePatterns PS00211 ABC transporters family signature. 142 156 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS33760 a74f530a7d386cc08c8fdda696f7cb48 558 SUPERFAMILY SSF52540 274 522 2.04E-46 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33760 a74f530a7d386cc08c8fdda696f7cb48 558 Gene3D G3DSA:3.40.50.300 282 522 9.7E-51 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33760 a74f530a7d386cc08c8fdda696f7cb48 558 Gene3D G3DSA:3.40.50.300 1 232 6.8E-59 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33760 a74f530a7d386cc08c8fdda696f7cb48 558 SMART SM00382 313 511 6.6E-10 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS33760 a74f530a7d386cc08c8fdda696f7cb48 558 SMART SM00382 28 220 1.1E-10 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS33760 a74f530a7d386cc08c8fdda696f7cb48 558 Pfam PF00005 ABC transporter 305 462 4.1E-18 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS33760 a74f530a7d386cc08c8fdda696f7cb48 558 Pfam PF00005 ABC transporter 19 170 2.5E-25 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS33760 a74f530a7d386cc08c8fdda696f7cb48 558 SUPERFAMILY SSF52540 2 232 3.19E-55 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS16810 cc4a50bc6e626ff279dc8490e26fef98 115 SUPERFAMILY SSF50346 13 110 1.7E-16 T 09-03-2017 IPR011033 PRC-barrel-like TK78_RS10825 e6ab1d9423b792a173d39099547fc93c 363 Gene3D G3DSA:3.40.630.10 19 174 1.4E-44 T 09-03-2017 TK78_RS10825 e6ab1d9423b792a173d39099547fc93c 363 Gene3D G3DSA:3.40.630.10 284 360 1.4E-44 T 09-03-2017 TK78_RS10825 e6ab1d9423b792a173d39099547fc93c 363 SUPERFAMILY SSF53187 20 186 7.11E-41 T 09-03-2017 TK78_RS10825 e6ab1d9423b792a173d39099547fc93c 363 SUPERFAMILY SSF53187 283 361 7.11E-41 T 09-03-2017 TK78_RS10825 e6ab1d9423b792a173d39099547fc93c 363 SUPERFAMILY SSF55031 174 274 5.53E-20 T 09-03-2017 IPR011650 Peptidase M20, dimerisation domain TK78_RS10825 e6ab1d9423b792a173d39099547fc93c 363 TIGRFAM TIGR01900 dapE-gram_pos: succinyl-diaminopimelate desuccinylase 18 362 1.2E-157 T 09-03-2017 IPR010174 Succinyl-diaminopimelate desuccinylase, DapE GO:0009014|GO:0009089 KEGG: 00300+3.5.1.18 TK78_RS10825 e6ab1d9423b792a173d39099547fc93c 363 Gene3D G3DSA:3.30.70.360 175 274 1.4E-23 T 09-03-2017 IPR011650 Peptidase M20, dimerisation domain TK78_RS10825 e6ab1d9423b792a173d39099547fc93c 363 Pfam PF01546 Peptidase family M20/M25/M40 73 353 1.2E-20 T 09-03-2017 IPR002933 Peptidase M20 GO:0008152|GO:0016787 TK78_RS10825 e6ab1d9423b792a173d39099547fc93c 363 Pfam PF07687 Peptidase dimerisation domain 174 272 6.0E-14 T 09-03-2017 IPR011650 Peptidase M20, dimerisation domain TK78_RS27160 a7cd6b2b1f257dc9702cb63415b4f0f6 313 SUPERFAMILY SSF55174 19 112 4.71E-7 T 09-03-2017 TK78_RS27160 a7cd6b2b1f257dc9702cb63415b4f0f6 313 Gene3D G3DSA:3.10.290.10 19 61 1.8E-8 T 09-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 TK78_RS27160 a7cd6b2b1f257dc9702cb63415b4f0f6 313 ProSitePatterns PS01129 Rlu family of pseudouridine synthase signature. 139 153 - T 09-03-2017 IPR006224 Pseudouridine synthase, RluC/RluD, conserved site GO:0001522|GO:0003723|GO:0009451|GO:0009982 TK78_RS27160 a7cd6b2b1f257dc9702cb63415b4f0f6 313 SUPERFAMILY SSF55120 82 309 1.36E-68 T 09-03-2017 IPR020103 Pseudouridine synthase, catalytic domain GO:0001522|GO:0003723|GO:0009451|GO:0009982 TK78_RS27160 a7cd6b2b1f257dc9702cb63415b4f0f6 313 TIGRFAM TIGR00005 rluA_subfam: pseudouridine synthase, RluA family 17 307 6.6E-85 T 09-03-2017 IPR006225 Pseudouridine synthase, RluC/RluD GO:0001522|GO:0003723|GO:0009451|GO:0009982 TK78_RS27160 a7cd6b2b1f257dc9702cb63415b4f0f6 313 Pfam PF00849 RNA pseudouridylate synthase 93 247 4.0E-30 T 09-03-2017 IPR006145 Pseudouridine synthase, RsuA/RluB/C/D/E/F GO:0001522|GO:0003723|GO:0009451|GO:0009982 TK78_RS27160 a7cd6b2b1f257dc9702cb63415b4f0f6 313 Pfam PF01479 S4 domain 19 62 1.4E-5 T 09-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 TK78_RS01325 bac9ae8622d87e9645e7dabbfee39af3 67 SMART SM00357 3 67 1.4E-30 T 09-03-2017 IPR011129 Cold shock protein GO:0003676 TK78_RS01325 bac9ae8622d87e9645e7dabbfee39af3 67 Gene3D G3DSA:2.40.50.140 1 65 2.6E-30 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS01325 bac9ae8622d87e9645e7dabbfee39af3 67 PRINTS PR00050 Cold shock protein signature 25 34 3.5E-17 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS01325 bac9ae8622d87e9645e7dabbfee39af3 67 PRINTS PR00050 Cold shock protein signature 4 19 3.5E-17 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS01325 bac9ae8622d87e9645e7dabbfee39af3 67 PRINTS PR00050 Cold shock protein signature 40 58 3.5E-17 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS01325 bac9ae8622d87e9645e7dabbfee39af3 67 Pfam PF00313 'Cold-shock' DNA-binding domain 3 66 8.8E-31 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS01325 bac9ae8622d87e9645e7dabbfee39af3 67 PIRSF PIRSF002599 1 67 1.5E-25 T 09-03-2017 IPR012156 Cold shock, CspA GO:0003676 TK78_RS01325 bac9ae8622d87e9645e7dabbfee39af3 67 ProSitePatterns PS00352 'Cold-shock' domain signature. 15 34 - T 09-03-2017 IPR019844 Cold-shock conserved site TK78_RS01325 bac9ae8622d87e9645e7dabbfee39af3 67 SUPERFAMILY SSF50249 1 65 1.81E-24 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS04930 98945254218d5093f8af305f23c70eab 194 Pfam PF12840 Helix-turn-helix domain 17 67 1.2E-9 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS04930 98945254218d5093f8af305f23c70eab 194 Gene3D G3DSA:1.10.10.10 18 80 7.3E-10 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS04930 98945254218d5093f8af305f23c70eab 194 SUPERFAMILY SSF46785 18 112 2.97E-12 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS24870 b6cd4630139c8f0405f8ad0cca7f1781 418 Gene3D G3DSA:1.20.1250.20 26 208 2.1E-17 T 09-03-2017 TK78_RS24870 b6cd4630139c8f0405f8ad0cca7f1781 418 SUPERFAMILY SSF103473 26 411 8.11E-35 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS24870 b6cd4630139c8f0405f8ad0cca7f1781 418 Gene3D G3DSA:1.20.1250.20 267 414 8.1E-11 T 09-03-2017 TK78_RS24870 b6cd4630139c8f0405f8ad0cca7f1781 418 Pfam PF05977 Transmembrane secretion effector 19 402 8.3E-32 T 09-03-2017 IPR010290 Transmembrane secretion effector TK78_RS22295 83f41ab9e427d2a5dd1c97d2f62534e8 323 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 34 44 1.3E-9 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS22295 83f41ab9e427d2a5dd1c97d2f62534e8 323 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 23 34 1.3E-9 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS22295 83f41ab9e427d2a5dd1c97d2f62534e8 323 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 44 55 1.3E-9 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS22295 83f41ab9e427d2a5dd1c97d2f62534e8 323 Gene3D G3DSA:3.40.190.10 109 191 1.4E-8 T 09-03-2017 TK78_RS22295 83f41ab9e427d2a5dd1c97d2f62534e8 323 SUPERFAMILY SSF53850 107 295 1.09E-9 T 09-03-2017 TK78_RS22295 83f41ab9e427d2a5dd1c97d2f62534e8 323 SUPERFAMILY SSF46785 6 86 4.96E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS22295 83f41ab9e427d2a5dd1c97d2f62534e8 323 Pfam PF03466 LysR substrate binding domain 107 291 3.7E-9 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS22295 83f41ab9e427d2a5dd1c97d2f62534e8 323 Gene3D G3DSA:1.10.10.10 7 83 5.0E-28 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS22295 83f41ab9e427d2a5dd1c97d2f62534e8 323 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 9 67 4.7E-21 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS24455 ad76029995136ccc4be67cd5c288dcc3 221 Pfam PF04093 rod shape-determining protein MreD 3 131 1.8E-5 T 09-03-2017 IPR007227 Cell shape-determining protein MreD GO:0008360|GO:0016021 TK78_RS24455 ad76029995136ccc4be67cd5c288dcc3 221 TIGRFAM TIGR03426 shape_MreD: rod shape-determining protein MreD 7 158 8.2E-17 T 09-03-2017 IPR007227 Cell shape-determining protein MreD GO:0008360|GO:0016021 TK78_RS12770 dd1e7da5198fca686b5c138e9cd868df 280 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 100 269 1.6E-13 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS12770 dd1e7da5198fca686b5c138e9cd868df 280 Gene3D G3DSA:1.10.3720.10 4 268 3.1E-49 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS12770 dd1e7da5198fca686b5c138e9cd868df 280 SUPERFAMILY SSF161098 4 280 1.2E-53 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS25295 aa6cf52e82edd2bca2a7c2040b90d8a9 970 Gene3D G3DSA:3.40.50.300 280 392 3.1E-13 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS25295 aa6cf52e82edd2bca2a7c2040b90d8a9 970 Gene3D G3DSA:3.40.50.300 442 518 3.1E-13 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS25295 aa6cf52e82edd2bca2a7c2040b90d8a9 970 SUPERFAMILY SSF52540 305 358 6.6E-25 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS25295 aa6cf52e82edd2bca2a7c2040b90d8a9 970 SUPERFAMILY SSF52540 413 513 6.6E-25 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS25295 aa6cf52e82edd2bca2a7c2040b90d8a9 970 SUPERFAMILY SSF52540 584 718 6.6E-25 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS25295 aa6cf52e82edd2bca2a7c2040b90d8a9 970 TIGRFAM TIGR01596 cas3_HD: CRISPR-associated endonuclease Cas3-HD 37 235 3.2E-22 T 09-03-2017 IPR006483 CRISPR-associated Cas3-HD domain TK78_RS25295 aa6cf52e82edd2bca2a7c2040b90d8a9 970 TIGRFAM TIGR01587 cas3_core: CRISPR-associated helicase Cas3 437 721 4.6E-45 T 09-03-2017 IPR006474 Helicase Cas3, CRISPR-associated, core TK78_RS25295 aa6cf52e82edd2bca2a7c2040b90d8a9 970 SUPERFAMILY SSF109604 65 89 6.28E-5 T 09-03-2017 TK78_RS25295 aa6cf52e82edd2bca2a7c2040b90d8a9 970 SUPERFAMILY SSF109604 120 161 6.28E-5 T 09-03-2017 TK78_RS25295 aa6cf52e82edd2bca2a7c2040b90d8a9 970 SMART SM00490 627 717 6.9E-4 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS25295 aa6cf52e82edd2bca2a7c2040b90d8a9 970 Gene3D G3DSA:3.40.50.300 604 718 3.4E-9 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18520 ae30eae444f16b8dc24aa4f58dea039c 455 SUPERFAMILY SSF55874 328 450 1.32E-8 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS18520 ae30eae444f16b8dc24aa4f58dea039c 455 Gene3D G3DSA:3.30.565.10 332 399 9.1E-5 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS18520 ae30eae444f16b8dc24aa4f58dea039c 455 Pfam PF07730 Histidine kinase 239 304 1.4E-18 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS31405 98ac5e5a9207d8bf80f1018b138b456e 389 Pfam PF12320 Type 5 capsule protein repressor C-terminal domain 269 355 3.4E-7 T 09-03-2017 IPR026843 Nuclease SbcCD subunit D, C-terminal domain TK78_RS31405 98ac5e5a9207d8bf80f1018b138b456e 389 Gene3D G3DSA:3.60.21.10 2 260 1.7E-73 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS31405 98ac5e5a9207d8bf80f1018b138b456e 389 SUPERFAMILY SSF56300 2 309 3.14E-56 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS31405 98ac5e5a9207d8bf80f1018b138b456e 389 Pfam PF00149 Calcineurin-like phosphoesterase 2 95 6.0E-13 T 09-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 TK78_RS31405 98ac5e5a9207d8bf80f1018b138b456e 389 TIGRFAM TIGR00619 sbcd: exonuclease SbcCD, D subunit 2 244 1.7E-54 T 09-03-2017 IPR004593 Nuclease SbcCD subunit D GO:0004519|GO:0006259|GO:0008408 TK78_RS10660 bacfb2d09484513facd271332e152581 474 Pfam PF11350 Protein of unknown function (DUF3152) 291 472 1.4E-58 T 09-03-2017 IPR022603 Domain of unknown function DUF3152 TK78_RS10660 bacfb2d09484513facd271332e152581 474 SUPERFAMILY SSF55486 338 455 1.62E-13 T 09-03-2017 TK78_RS14065 9b318608e187ecc96c771acb1ba51d1d 297 PRINTS PR00412 Epoxide hydrolase signature 104 117 1.2E-5 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS14065 9b318608e187ecc96c771acb1ba51d1d 297 PRINTS PR00412 Epoxide hydrolase signature 118 131 1.2E-5 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS14065 9b318608e187ecc96c771acb1ba51d1d 297 PRINTS PR00412 Epoxide hydrolase signature 258 280 1.2E-5 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS14065 9b318608e187ecc96c771acb1ba51d1d 297 PRINTS PR00412 Epoxide hydrolase signature 59 74 1.2E-5 T 09-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 TK78_RS14065 9b318608e187ecc96c771acb1ba51d1d 297 SUPERFAMILY SSF53474 10 283 1.54E-50 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS14065 9b318608e187ecc96c771acb1ba51d1d 297 Pfam PF12697 Alpha/beta hydrolase family 36 275 3.8E-20 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS14065 9b318608e187ecc96c771acb1ba51d1d 297 Gene3D G3DSA:3.40.50.1820 6 283 3.2E-60 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS33545 31e0d743cf6232d4dc6f974f8af6b57b 398 SUPERFAMILY SSF53686 24 334 6.29E-64 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS33545 31e0d743cf6232d4dc6f974f8af6b57b 398 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 30 313 1.7E-46 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS33545 31e0d743cf6232d4dc6f974f8af6b57b 398 Gene3D G3DSA:3.40.50.1100 152 325 3.1E-36 T 09-03-2017 TK78_RS33545 31e0d743cf6232d4dc6f974f8af6b57b 398 Gene3D G3DSA:3.40.50.1100 60 151 3.0E-18 T 09-03-2017 TK78_RS30845 59960e2a04c9ae6ba3c5f07e8f166627 131 Gene3D G3DSA:3.30.1330.40 8 130 1.7E-27 T 09-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like TK78_RS30845 59960e2a04c9ae6ba3c5f07e8f166627 131 Pfam PF01042 Endoribonuclease L-PSP 27 130 2.3E-17 T 09-03-2017 IPR006175 YjgF/YER057c/UK114 family TK78_RS30845 59960e2a04c9ae6ba3c5f07e8f166627 131 SUPERFAMILY SSF55298 27 130 5.5E-23 T 09-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like TK78_RS03260 514335593e22023ba1af3c38b7e23966 545 ProSitePatterns PS00211 ABC transporters family signature. 159 173 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS03260 514335593e22023ba1af3c38b7e23966 545 SMART SM00382 29 232 7.8E-10 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS03260 514335593e22023ba1af3c38b7e23966 545 SMART SM00382 374 541 5.8E-10 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS03260 514335593e22023ba1af3c38b7e23966 545 SUPERFAMILY SSF52540 5 229 8.47E-39 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03260 514335593e22023ba1af3c38b7e23966 545 Gene3D G3DSA:3.40.50.300 7 273 5.9E-41 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03260 514335593e22023ba1af3c38b7e23966 545 Gene3D G3DSA:3.40.50.300 369 544 3.7E-28 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03260 514335593e22023ba1af3c38b7e23966 545 Pfam PF00005 ABC transporter 368 495 3.1E-14 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS03260 514335593e22023ba1af3c38b7e23966 545 Pfam PF00005 ABC transporter 23 187 1.6E-21 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS03260 514335593e22023ba1af3c38b7e23966 545 SUPERFAMILY SSF52540 364 544 5.18E-33 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22700 1648c9fc5e33ec0cad93b5c19d45d1df 105 Pfam PF12277 Protein of unknown function (DUF3618) 4 49 2.8E-13 T 09-03-2017 IPR022062 Protein of unknown function DUF3618 TK78_RS17635 b038a2d0a1dd53902cbff5913538513f 386 SUPERFAMILY SSF52518 37 373 6.61E-92 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS17635 b038a2d0a1dd53902cbff5913538513f 386 Gene3D G3DSA:3.40.50.970 32 365 6.1E-119 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS17635 b038a2d0a1dd53902cbff5913538513f 386 TIGRFAM TIGR03181 PDH_E1_alph_x: pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit 40 366 2.9E-128 T 09-03-2017 IPR017596 Pyruvate dehydrogenase E1 component subunit alpha/BCKADH E1-alpha KEGG: 00010+1.2.4.1|KEGG: 00020+1.2.4.1|KEGG: 00620+1.2.4.1 TK78_RS17635 b038a2d0a1dd53902cbff5913538513f 386 Pfam PF00676 Dehydrogenase E1 component 67 335 8.1E-74 T 09-03-2017 IPR001017 Dehydrogenase, E1 component GO:0008152|GO:0016624 TK78_RS28885 238bc48c0537b5a2b111aea4d3028215 361 Pfam PF00089 Trypsin 200 351 1.2E-11 T 09-03-2017 IPR001254 Serine proteases, trypsin domain GO:0004252|GO:0006508 TK78_RS28885 238bc48c0537b5a2b111aea4d3028215 361 SUPERFAMILY SSF50494 180 354 7.48E-39 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS28885 238bc48c0537b5a2b111aea4d3028215 361 Gene3D G3DSA:3.30.300.50 39 100 6.5E-8 T 09-03-2017 TK78_RS28885 238bc48c0537b5a2b111aea4d3028215 361 Gene3D G3DSA:3.30.300.50 102 150 5.7E-6 T 09-03-2017 TK78_RS28885 238bc48c0537b5a2b111aea4d3028215 361 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 261 281 1.5E-47 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS28885 238bc48c0537b5a2b111aea4d3028215 361 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 282 299 1.5E-47 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS28885 238bc48c0537b5a2b111aea4d3028215 361 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 326 340 1.5E-47 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS28885 238bc48c0537b5a2b111aea4d3028215 361 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 200 214 1.5E-47 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS28885 238bc48c0537b5a2b111aea4d3028215 361 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 302 325 1.5E-47 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS28885 238bc48c0537b5a2b111aea4d3028215 361 Gene3D G3DSA:2.40.10.10 259 348 1.2E-29 T 09-03-2017 TK78_RS28885 238bc48c0537b5a2b111aea4d3028215 361 Pfam PF02983 Alpha-lytic protease prodomain 102 156 1.8E-15 T 09-03-2017 IPR004236 Peptidase S1A, alpha-lytic prodomain GO:0005576|GO:0006508|GO:0008236 TK78_RS28885 238bc48c0537b5a2b111aea4d3028215 361 Gene3D G3DSA:2.40.10.10 174 258 1.9E-30 T 09-03-2017 TK78_RS28885 238bc48c0537b5a2b111aea4d3028215 361 PIRSF PIRSF001134 1 361 1.8E-140 T 09-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 TK78_RS28885 238bc48c0537b5a2b111aea4d3028215 361 ProSitePatterns PS00134 Serine proteases, trypsin family, histidine active site. 202 207 - T 09-03-2017 IPR018114 Serine proteases, trypsin family, histidine active site GO:0004252|GO:0006508 TK78_RS28885 238bc48c0537b5a2b111aea4d3028215 361 ProSitePatterns PS00135 Serine proteases, trypsin family, serine active site. 311 322 - T 09-03-2017 IPR033116 Serine proteases, trypsin family, serine active site TK78_RS19650 da54987719df331a6e482d8fc93a380e 162 Pfam PF11377 Protein of unknown function (DUF3180) 9 149 2.7E-36 T 09-03-2017 IPR021517 Protein of unknown function DUF3180 TK78_RS08825 0dc424b72ab58186ab0b3367597425c2 746 Gene3D G3DSA:1.20.1640.10 140 338 7.1E-31 T 09-03-2017 TK78_RS08825 0dc424b72ab58186ab0b3367597425c2 746 Gene3D G3DSA:1.20.1640.10 496 702 1.6E-25 T 09-03-2017 TK78_RS08825 0dc424b72ab58186ab0b3367597425c2 746 Pfam PF03176 MMPL family 431 696 1.2E-30 T 09-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 TK78_RS08825 0dc424b72ab58186ab0b3367597425c2 746 Pfam PF03176 MMPL family 44 367 1.3E-69 T 09-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 TK78_RS08825 0dc424b72ab58186ab0b3367597425c2 746 SUPERFAMILY SSF82866 455 696 1.57E-23 T 09-03-2017 TK78_RS08825 0dc424b72ab58186ab0b3367597425c2 746 SUPERFAMILY SSF82866 110 330 3.53E-33 T 09-03-2017 TK78_RS13615 3ca49c84880c879ba340d66078d0696c 99 Hamap MF_01456 NAD(P)H-quinone oxidoreductase subunit 4L, chloroplastic [ndhE]. 1 99 19.392 T 09-03-2017 IPR001133 NADH-ubiquinone oxidoreductase chain 4L/K GO:0016651|GO:0042773|GO:0055114 TK78_RS13615 3ca49c84880c879ba340d66078d0696c 99 Pfam PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 6 93 1.0E-23 T 09-03-2017 IPR001133 NADH-ubiquinone oxidoreductase chain 4L/K GO:0016651|GO:0042773|GO:0055114 TK78_RS00845 003c3cae1c537e5500773d62718d4b67 138 SUPERFAMILY SSF55961 1 134 1.5E-32 T 09-03-2017 TK78_RS00845 003c3cae1c537e5500773d62718d4b67 138 Pfam PF10604 Polyketide cyclase / dehydrase and lipid transport 3 135 3.3E-24 T 09-03-2017 IPR019587 Polyketide cyclase/dehydrase TK78_RS00845 003c3cae1c537e5500773d62718d4b67 138 Gene3D G3DSA:3.30.530.20 4 136 1.8E-43 T 09-03-2017 IPR023393 START-like domain TK78_RS11835 53cffed4968d839871e5c92df95b23f7 165 TIGRFAM TIGR01462 greA: transcription elongation factor GreA 10 159 2.8E-43 T 09-03-2017 IPR006359 Transcription elongation factor GreA GO:0003677|GO:0032784 TK78_RS11835 53cffed4968d839871e5c92df95b23f7 165 PIRSF PIRSF006092 3 164 6.0E-34 T 09-03-2017 IPR023459 Transcription elongation factor GreA/GreB family GO:0070063 TK78_RS11835 53cffed4968d839871e5c92df95b23f7 165 SUPERFAMILY SSF54534 84 160 1.01E-10 T 09-03-2017 TK78_RS11835 53cffed4968d839871e5c92df95b23f7 165 Pfam PF01272 Transcription elongation factor, GreA/GreB, C-term 86 160 2.2E-12 T 09-03-2017 IPR001437 Transcription elongation factor, GreA/GreB, C-terminal GO:0003677|GO:0032784 TK78_RS11835 53cffed4968d839871e5c92df95b23f7 165 SUPERFAMILY SSF46557 8 82 7.46E-23 T 09-03-2017 IPR022691 Transcription elongation factor, GreA/GreB, N-terminal GO:0003677|GO:0032784 TK78_RS11835 53cffed4968d839871e5c92df95b23f7 165 Hamap MF_00105 Transcription elongation factor GreA [greA]. 7 161 27.583 T 09-03-2017 IPR028624 Transcription elongation factor GreA/GreB GO:0003677|GO:0032784|GO:0070063 TK78_RS11835 53cffed4968d839871e5c92df95b23f7 165 ProSitePatterns PS00829 Prokaryotic transcription elongation factors signature 1. 22 53 - T 09-03-2017 IPR018151 Transcription elongation factor, GreA/GreB, conserved site GO:0003677|GO:0032784 TK78_RS11835 53cffed4968d839871e5c92df95b23f7 165 Gene3D G3DSA:3.10.50.30 81 162 1.2E-15 T 09-03-2017 IPR001437 Transcription elongation factor, GreA/GreB, C-terminal GO:0003677|GO:0032784 TK78_RS11835 53cffed4968d839871e5c92df95b23f7 165 Pfam PF03449 Transcription elongation factor, N-terminal 10 79 1.1E-25 T 09-03-2017 IPR022691 Transcription elongation factor, GreA/GreB, N-terminal GO:0003677|GO:0032784 TK78_RS11835 53cffed4968d839871e5c92df95b23f7 165 Gene3D G3DSA:1.10.287.180 7 79 4.1E-27 T 09-03-2017 IPR022691 Transcription elongation factor, GreA/GreB, N-terminal GO:0003677|GO:0032784 TK78_RS10445 055f5b59114265b17bc0b0d3967e1c50 237 Pfam PF13398 Peptidase M50B-like 27 229 2.3E-64 T 09-03-2017 TK78_RS27420 df076ed64dc1d92eaf49587df9ce83d7 303 Gene3D G3DSA:1.20.1540.10 68 265 2.3E-37 T 09-03-2017 IPR022764 Peptidase S54, rhomboid domain GO:0004252|GO:0016021 TK78_RS27420 df076ed64dc1d92eaf49587df9ce83d7 303 Pfam PF01694 Rhomboid family 127 266 8.7E-29 T 09-03-2017 IPR022764 Peptidase S54, rhomboid domain GO:0004252|GO:0016021 TK78_RS27420 df076ed64dc1d92eaf49587df9ce83d7 303 SUPERFAMILY SSF144091 67 268 1.44E-39 T 09-03-2017 TK78_RS12800 7f6c250874e41f7b567fb5d79a039650 318 Pfam PF01522 Polysaccharide deacetylase 132 251 2.0E-26 T 09-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 TK78_RS12800 7f6c250874e41f7b567fb5d79a039650 318 SUPERFAMILY SSF88713 112 317 3.21E-39 T 09-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 TK78_RS12800 7f6c250874e41f7b567fb5d79a039650 318 Gene3D G3DSA:3.20.20.370 109 317 1.4E-39 T 09-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 TK78_RS18265 2441f0182ee57473ce63a9fd013a7159 284 Pfam PF03724 META domain 157 268 2.3E-30 T 09-03-2017 IPR005184 Domain of unknown function DUF306, Meta/HslJ TK78_RS18265 2441f0182ee57473ce63a9fd013a7159 284 Pfam PF03724 META domain 45 149 9.6E-22 T 09-03-2017 IPR005184 Domain of unknown function DUF306, Meta/HslJ TK78_RS17600 38e77f5b9b2914e83a573b20d275392e 372 TIGRFAM TIGR02156 PA_CoA_Oxy1: phenylacetate-CoA oxygenase, PaaG subunit 43 331 2.6E-154 T 09-03-2017 IPR011881 1,2-phenylacetyl-CoA epoxidase, subunit A GO:0010124|GO:0097266 KEGG: 00360+1.14.13.14+1.14.13.149|KEGG: 00940+1.14.13.14|MetaCyc: PWY-5176 TK78_RS17600 38e77f5b9b2914e83a573b20d275392e 372 Pfam PF05138 Phenylacetic acid catabolic protein 53 327 4.5E-105 T 09-03-2017 IPR007814 1,2-phenylacetyl-CoA epoxidase, subunit A/C GO:0010124 TK78_RS17600 38e77f5b9b2914e83a573b20d275392e 372 Gene3D G3DSA:1.20.1260.10 53 308 6.3E-105 T 09-03-2017 IPR012347 Ferritin-related TK78_RS17600 38e77f5b9b2914e83a573b20d275392e 372 SUPERFAMILY SSF47240 63 306 6.89E-83 T 09-03-2017 IPR009078 Ferritin-like superfamily TK78_RS10355 3b89618a37848ca261cfc8e649b746c2 324 SUPERFAMILY SSF46689 265 315 2.51E-9 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS10355 3b89618a37848ca261cfc8e649b746c2 324 SUPERFAMILY SSF52317 3 194 1.45E-47 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS10355 3b89618a37848ca261cfc8e649b746c2 324 Gene3D G3DSA:3.40.50.880 4 222 2.3E-51 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS10355 3b89618a37848ca261cfc8e649b746c2 324 SUPERFAMILY SSF46689 217 262 5.38E-12 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS10355 3b89618a37848ca261cfc8e649b746c2 324 Gene3D G3DSA:1.10.10.60 223 265 1.8E-18 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS10355 3b89618a37848ca261cfc8e649b746c2 324 Gene3D G3DSA:1.10.10.60 268 315 4.2E-11 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS10355 3b89618a37848ca261cfc8e649b746c2 324 Pfam PF12833 Helix-turn-helix domain 234 312 1.9E-22 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS10355 3b89618a37848ca261cfc8e649b746c2 324 SMART SM00342 228 311 5.0E-24 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS10355 3b89618a37848ca261cfc8e649b746c2 324 Pfam PF01965 DJ-1/PfpI family 3 173 2.5E-18 T 09-03-2017 IPR002818 DJ-1/PfpI TK78_RS09230 1f36ad8849f8dbc16b4aa0db0f3945fa 277 Gene3D G3DSA:3.20.20.370 71 270 3.1E-35 T 09-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 TK78_RS09230 1f36ad8849f8dbc16b4aa0db0f3945fa 277 SUPERFAMILY SSF88713 63 266 4.89E-37 T 09-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 TK78_RS09230 1f36ad8849f8dbc16b4aa0db0f3945fa 277 Pfam PF01522 Polysaccharide deacetylase 75 197 1.8E-18 T 09-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 TK78_RS08835 2552806ac12db97111623c1899487ce3 419 PRINTS PR00758 Arsenical pump membrane protein signature 353 378 2.6E-16 T 09-03-2017 IPR000802 Arsenical pump membrane protein, ArsB GO:0015105|GO:0015700|GO:0016021 TK78_RS08835 2552806ac12db97111623c1899487ce3 419 PRINTS PR00758 Arsenical pump membrane protein signature 107 131 2.6E-16 T 09-03-2017 IPR000802 Arsenical pump membrane protein, ArsB GO:0015105|GO:0015700|GO:0016021 TK78_RS08835 2552806ac12db97111623c1899487ce3 419 PRINTS PR00758 Arsenical pump membrane protein signature 180 203 2.6E-16 T 09-03-2017 IPR000802 Arsenical pump membrane protein, ArsB GO:0015105|GO:0015700|GO:0016021 TK78_RS08835 2552806ac12db97111623c1899487ce3 419 PRINTS PR00758 Arsenical pump membrane protein signature 386 410 2.6E-16 T 09-03-2017 IPR000802 Arsenical pump membrane protein, ArsB GO:0015105|GO:0015700|GO:0016021 TK78_RS08835 2552806ac12db97111623c1899487ce3 419 Pfam PF02040 Arsenical pump membrane protein 14 409 2.3E-27 T 09-03-2017 IPR000802 Arsenical pump membrane protein, ArsB GO:0015105|GO:0015700|GO:0016021 TK78_RS04070 2c3844c6183f2e64f5906c10ff4d711b 722 Pfam PF04020 Mycobacterial 4 TMS phage holin, superfamily IV 15 126 1.5E-9 T 09-03-2017 IPR007165 Mycobacterial 4 TMS phage holin, superfamily IV TK78_RS04070 2c3844c6183f2e64f5906c10ff4d711b 722 Gene3D G3DSA:3.40.720.10 144 251 1.4E-14 T 09-03-2017 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 TK78_RS04070 2c3844c6183f2e64f5906c10ff4d711b 722 Gene3D G3DSA:3.40.720.10 285 449 1.4E-14 T 09-03-2017 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 TK78_RS04070 2c3844c6183f2e64f5906c10ff4d711b 722 Pfam PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 172 484 2.5E-9 T 09-03-2017 IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase GO:0003824 TK78_RS04070 2c3844c6183f2e64f5906c10ff4d711b 722 SUPERFAMILY SSF53649 366 541 9.59E-15 T 09-03-2017 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 TK78_RS04070 2c3844c6183f2e64f5906c10ff4d711b 722 SUPERFAMILY SSF53649 169 338 9.59E-15 T 09-03-2017 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 TK78_RS04070 2c3844c6183f2e64f5906c10ff4d711b 722 SUPERFAMILY SSF53649 597 646 9.59E-15 T 09-03-2017 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 TK78_RS17930 54f0c9b4ccf1c92d42701eb81260046a 1716 Pfam PF12458 ATPase involved in DNA repair 41 488 2.0E-184 T 09-03-2017 IPR020958 DUF3686 TK78_RS17930 54f0c9b4ccf1c92d42701eb81260046a 1716 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 1300 1376 5.5E-5 T 09-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 TK78_RS17930 54f0c9b4ccf1c92d42701eb81260046a 1716 Gene3D G3DSA:3.40.50.300 1289 1429 9.1E-13 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17930 54f0c9b4ccf1c92d42701eb81260046a 1716 SUPERFAMILY SSF52540 1297 1490 5.8E-13 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18920 7dad5121b316ca666258e065e1f7e3df 275 SUPERFAMILY SSF56112 29 261 5.1E-29 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS18920 7dad5121b316ca666258e065e1f7e3df 275 Pfam PF01636 Phosphotransferase enzyme family 127 194 1.7E-10 T 09-03-2017 IPR002575 Aminoglycoside phosphotransferase TK78_RS18920 7dad5121b316ca666258e065e1f7e3df 275 Gene3D G3DSA:3.90.1200.10 44 216 1.6E-20 T 09-03-2017 TK78_RS10370 23c2c813ed1b01fcad4e7bff08045a63 427 Gene3D G3DSA:1.10.3210.10 274 379 4.1E-6 T 09-03-2017 IPR006674 HD domain TK78_RS10370 23c2c813ed1b01fcad4e7bff08045a63 427 SUPERFAMILY SSF109604 254 414 4.59E-10 T 09-03-2017 TK78_RS08840 ebad0c02ded0aac3bb371de524ab3ade 502 Hamap MF_00121 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B [gatB]. 15 499 35.757 T 09-03-2017 IPR004413 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit GO:0016884 TK78_RS08840 ebad0c02ded0aac3bb371de524ab3ade 502 ProSitePatterns PS01234 Glutamyl-tRNA(Gln) amidotransferase subunit B signature. 164 178 - T 09-03-2017 IPR017958 Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site GO:0016884 TK78_RS08840 ebad0c02ded0aac3bb371de524ab3ade 502 SMART SM00845 351 498 5.7E-59 T 09-03-2017 IPR018027 Asn/Gln amidotransferase GO:0016884 TK78_RS08840 ebad0c02ded0aac3bb371de524ab3ade 502 SUPERFAMILY SSF89095 351 498 1.11E-25 T 09-03-2017 IPR003789 Aspartyl/glutamyl-tRNA amidotransferase subunit B-related GO:0016884 TK78_RS08840 ebad0c02ded0aac3bb371de524ab3ade 502 Pfam PF02637 GatB domain 353 498 1.9E-40 T 09-03-2017 IPR018027 Asn/Gln amidotransferase GO:0016884 TK78_RS08840 ebad0c02ded0aac3bb371de524ab3ade 502 Gene3D G3DSA:1.10.10.410 441 498 1.1E-4 T 09-03-2017 IPR023168 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, C-terminal TK78_RS08840 ebad0c02ded0aac3bb371de524ab3ade 502 Pfam PF02934 GatB/GatE catalytic domain 19 313 9.1E-101 T 09-03-2017 IPR006075 Aspartyl/Glutamyl-tRNA(Gln) amidotransferase, subunit B/E, catalytic GO:0016874 TK78_RS08840 ebad0c02ded0aac3bb371de524ab3ade 502 SUPERFAMILY SSF55931 18 320 5.43E-108 T 09-03-2017 TK78_RS08840 ebad0c02ded0aac3bb371de524ab3ade 502 TIGRFAM TIGR00133 gatB: aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit 15 498 1.2E-141 T 09-03-2017 IPR004413 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit GO:0016884 TK78_RS30625 1cf2b0182a2f387d0c92ecab634f4e13 190 Pfam PF14024 Protein of unknown function (DUF4240) 1 138 2.3E-31 T 09-03-2017 IPR025334 Domain of unknown function (DUF4240 TK78_RS16470 fbe9be6bcc7cf892ade5a63ff30a5ca9 481 Pfam PF15975 Flotillin 344 433 1.5E-13 T 09-03-2017 IPR031905 Flotillin, C-terminal domain Reactome: R-HSA-8849932 TK78_RS16470 fbe9be6bcc7cf892ade5a63ff30a5ca9 481 SMART SM00244 24 205 0.002 T 09-03-2017 IPR001107 Band 7 domain TK78_RS16470 fbe9be6bcc7cf892ade5a63ff30a5ca9 481 SUPERFAMILY SSF117892 71 211 6.28E-25 T 09-03-2017 IPR001107 Band 7 domain TK78_RS16470 fbe9be6bcc7cf892ade5a63ff30a5ca9 481 Pfam PF01145 SPFH domain / Band 7 family 29 219 5.9E-21 T 09-03-2017 IPR001107 Band 7 domain TK78_RS02385 438f5babfcfbeefd23679e217897341d 389 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 195 383 3.8E-34 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS02385 438f5babfcfbeefd23679e217897341d 389 Gene3D G3DSA:3.60.40.10 297 331 4.0E-4 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS02385 438f5babfcfbeefd23679e217897341d 389 SMART SM00331 169 383 1.8E-19 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS02385 438f5babfcfbeefd23679e217897341d 389 SUPERFAMILY SSF81606 186 331 1.7E-10 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS04825 08da2b7dc55f627b1d62317643e265b2 324 Gene3D G3DSA:3.40.50.2300 37 160 7.5E-30 T 09-03-2017 TK78_RS04825 08da2b7dc55f627b1d62317643e265b2 324 SUPERFAMILY SSF53822 41 313 1.07E-46 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS04825 08da2b7dc55f627b1d62317643e265b2 324 Pfam PF13407 Periplasmic binding protein domain 43 287 3.0E-36 T 09-03-2017 IPR025997 Periplasmic binding protein TK78_RS04825 08da2b7dc55f627b1d62317643e265b2 324 Gene3D G3DSA:3.40.50.2300 161 286 2.5E-12 T 09-03-2017 TK78_RS02540 64b0a6a8e76062846bdc625ced5c46fe 454 SUPERFAMILY SSF50621 266 412 1.61E-29 T 09-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 TK78_RS02540 64b0a6a8e76062846bdc625ced5c46fe 454 Gene3D G3DSA:3.20.20.10 48 285 1.1E-57 T 09-03-2017 IPR029066 PLP-binding barrel TK78_RS02540 64b0a6a8e76062846bdc625ced5c46fe 454 Pfam PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 351 412 1.4E-7 T 09-03-2017 IPR022643 Orn/DAP/Arg decarboxylase 2, C-terminal GO:0003824 TK78_RS02540 64b0a6a8e76062846bdc625ced5c46fe 454 ProSitePatterns PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. 70 88 - T 09-03-2017 IPR022653 Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site TK78_RS02540 64b0a6a8e76062846bdc625ced5c46fe 454 PRINTS PR01181 Diaminopimelate decarboxylase signature 316 334 7.8E-6 T 09-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS02540 64b0a6a8e76062846bdc625ced5c46fe 454 PRINTS PR01181 Diaminopimelate decarboxylase signature 88 105 7.8E-6 T 09-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS02540 64b0a6a8e76062846bdc625ced5c46fe 454 PRINTS PR01181 Diaminopimelate decarboxylase signature 175 184 7.8E-6 T 09-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS02540 64b0a6a8e76062846bdc625ced5c46fe 454 Pfam PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 64 298 2.4E-40 T 09-03-2017 IPR022644 Orn/DAP/Arg decarboxylase 2, N-terminal GO:0003824 TK78_RS02540 64b0a6a8e76062846bdc625ced5c46fe 454 SUPERFAMILY SSF51419 46 299 3.78E-50 T 09-03-2017 IPR029066 PLP-binding barrel TK78_RS02540 64b0a6a8e76062846bdc625ced5c46fe 454 Gene3D G3DSA:2.40.37.10 286 439 1.5E-29 T 09-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 TK78_RS02540 64b0a6a8e76062846bdc625ced5c46fe 454 ProSitePatterns PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 238 255 - T 09-03-2017 IPR022657 Orn/DAP/Arg decarboxylase 2, conserved site TK78_RS02540 64b0a6a8e76062846bdc625ced5c46fe 454 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 70 88 3.8E-9 T 09-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TK78_RS02540 64b0a6a8e76062846bdc625ced5c46fe 454 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 288 307 3.8E-9 T 09-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TK78_RS02540 64b0a6a8e76062846bdc625ced5c46fe 454 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 90 102 3.8E-9 T 09-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TK78_RS02540 64b0a6a8e76062846bdc625ced5c46fe 454 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 202 215 3.8E-9 T 09-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TK78_RS02540 64b0a6a8e76062846bdc625ced5c46fe 454 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 393 406 3.8E-9 T 09-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TK78_RS19755 8423717cef2c6232a52ef99b06d23a72 563 SUPERFAMILY SSF46977 438 554 1.15E-27 T 09-03-2017 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS19755 8423717cef2c6232a52ef99b06d23a72 563 SUPERFAMILY SSF56425 240 357 4.04E-37 T 09-03-2017 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS19755 8423717cef2c6232a52ef99b06d23a72 563 Gene3D G3DSA:1.20.58.100 437 543 9.8E-23 T 09-03-2017 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS19755 8423717cef2c6232a52ef99b06d23a72 563 PIRSF PIRSF000171 13 555 1.6E-38 T 09-03-2017 IPR030664 Succinate dehydrogenase/fumarate reductase, alpha/adenylylsulphate reductase subunit Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS19755 8423717cef2c6232a52ef99b06d23a72 563 SUPERFAMILY SSF51905 361 416 1.3E-65 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS19755 8423717cef2c6232a52ef99b06d23a72 563 SUPERFAMILY SSF51905 6 269 1.3E-65 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS19755 8423717cef2c6232a52ef99b06d23a72 563 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 360 382 2.0E-11 T 09-03-2017 TK78_RS19755 8423717cef2c6232a52ef99b06d23a72 563 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 19 38 2.0E-11 T 09-03-2017 TK78_RS19755 8423717cef2c6232a52ef99b06d23a72 563 TIGRFAM TIGR00551 nadB: L-aspartate oxidase 17 525 8.3E-164 T 09-03-2017 IPR005288 L-aspartate oxidase GO:0005737|GO:0008734|GO:0009435|GO:0055114 KEGG: 00250+1.4.3.16|KEGG: 00760+1.4.3.16|MetaCyc: PWY-5316|MetaCyc: PWY-7342 TK78_RS19755 8423717cef2c6232a52ef99b06d23a72 563 Gene3D G3DSA:3.50.50.60 13 245 1.6E-100 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS19755 8423717cef2c6232a52ef99b06d23a72 563 Gene3D G3DSA:3.50.50.60 354 413 1.6E-100 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS19755 8423717cef2c6232a52ef99b06d23a72 563 Pfam PF02910 Fumarate reductase flavoprotein C-term 440 545 5.6E-18 T 09-03-2017 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS19755 8423717cef2c6232a52ef99b06d23a72 563 Gene3D G3DSA:3.90.700.10 246 353 2.1E-35 T 09-03-2017 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS19755 8423717cef2c6232a52ef99b06d23a72 563 Pfam PF00890 FAD binding domain 18 397 7.4E-98 T 09-03-2017 IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS19755 8423717cef2c6232a52ef99b06d23a72 563 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 18 40 4.6E-7 T 09-03-2017 TK78_RS19755 8423717cef2c6232a52ef99b06d23a72 563 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 375 382 4.6E-7 T 09-03-2017 TK78_RS25730 26daec5d12fa08d5cbccf17ead400851 584 SUPERFAMILY SSF56300 140 237 1.21E-12 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS25730 26daec5d12fa08d5cbccf17ead400851 584 SUPERFAMILY SSF56300 410 458 1.21E-12 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS25730 26daec5d12fa08d5cbccf17ead400851 584 SUPERFAMILY SSF56300 311 377 1.21E-12 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS25730 26daec5d12fa08d5cbccf17ead400851 584 Pfam PF09423 PhoD-like phosphatase 157 457 3.3E-16 T 09-03-2017 IPR018946 Alkaline phosphatase D-related TK78_RS25730 26daec5d12fa08d5cbccf17ead400851 584 Gene3D G3DSA:3.60.21.10 271 272 1.1E-5 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS25730 26daec5d12fa08d5cbccf17ead400851 584 Gene3D G3DSA:3.60.21.10 313 361 1.1E-5 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS25730 26daec5d12fa08d5cbccf17ead400851 584 Gene3D G3DSA:3.60.21.10 152 236 1.1E-5 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS09725 e3bea71289f1798c38af7a8855d8dd08 215 TIGRFAM TIGR00057 TIGR00057: tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family 13 207 8.0E-57 T 09-03-2017 IPR006070 YrdC-like domain GO:0003725 TK78_RS09725 e3bea71289f1798c38af7a8855d8dd08 215 SUPERFAMILY SSF55821 2 209 1.5E-56 T 09-03-2017 IPR017945 DHBP synthase RibB-like alpha/beta domain TK78_RS09725 e3bea71289f1798c38af7a8855d8dd08 215 Gene3D G3DSA:3.90.870.10 5 205 5.9E-64 T 09-03-2017 IPR017945 DHBP synthase RibB-like alpha/beta domain TK78_RS09725 e3bea71289f1798c38af7a8855d8dd08 215 Pfam PF01300 Telomere recombination 23 197 1.1E-45 T 09-03-2017 IPR006070 YrdC-like domain GO:0003725 TK78_RS11840 28f168eb1f7f053d56d0e4bbccc69024 287 PIRSF PIRSF006648 2 287 4.4E-73 T 09-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 TK78_RS11840 28f168eb1f7f053d56d0e4bbccc69024 287 Pfam PF01061 ABC-2 type transporter 28 238 5.6E-28 T 09-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 TK78_RS31825 9f71dad073704db00f82e9ade57588b8 140 PIRSF PIRSF004681 4 140 4.1E-27 T 09-03-2017 IPR001602 Uncharacterised protein family UPF0047 TK78_RS31825 9f71dad073704db00f82e9ade57588b8 140 Pfam PF01894 Uncharacterised protein family UPF0047 22 136 6.8E-23 T 09-03-2017 IPR001602 Uncharacterised protein family UPF0047 TK78_RS31825 9f71dad073704db00f82e9ade57588b8 140 Gene3D G3DSA:2.60.120.460 5 140 4.5E-31 T 09-03-2017 IPR001602 Uncharacterised protein family UPF0047 TK78_RS31825 9f71dad073704db00f82e9ade57588b8 140 SUPERFAMILY SSF111038 6 140 2.88E-31 T 09-03-2017 IPR001602 Uncharacterised protein family UPF0047 TK78_RS08730 4a05e68385704d8a2555feb10d1418d4 211 SUPERFAMILY SSF48498 91 187 2.33E-15 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS08730 4a05e68385704d8a2555feb10d1418d4 211 Pfam PF13977 Bacterial transcriptional repressor 104 198 5.9E-12 T 09-03-2017 TK78_RS08730 4a05e68385704d8a2555feb10d1418d4 211 SUPERFAMILY SSF46689 9 76 3.75E-12 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS08730 4a05e68385704d8a2555feb10d1418d4 211 Pfam PF00440 Bacterial regulatory proteins, tetR family 21 67 2.6E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS08730 4a05e68385704d8a2555feb10d1418d4 211 Gene3D G3DSA:1.10.357.10 12 185 2.7E-33 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS05870 1f1ee8ca810c77f953e018d96bd91470 249 Pfam PF13628 Domain of unknown function (DUF4142) 55 189 5.5E-19 T 09-03-2017 IPR025419 Domain of unknown function DUF4142 TK78_RS34180 6344edddb0007fad018c97604a94aaab 495 Gene3D G3DSA:1.25.40.10 242 452 6.6E-5 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS04480 29d36435e99df664839d17d374cdc9c7 217 Gene3D G3DSA:2.30.180.10 86 214 3.7E-34 T 09-03-2017 IPR000782 FAS1 domain TK78_RS04480 29d36435e99df664839d17d374cdc9c7 217 Pfam PF02469 Fasciclin domain 95 215 2.0E-32 T 09-03-2017 IPR000782 FAS1 domain TK78_RS04480 29d36435e99df664839d17d374cdc9c7 217 SUPERFAMILY SSF82153 72 216 2.22E-37 T 09-03-2017 IPR000782 FAS1 domain TK78_RS04480 29d36435e99df664839d17d374cdc9c7 217 SMART SM00554 119 216 1.4E-32 T 09-03-2017 IPR000782 FAS1 domain TK78_RS02895 9cbda617d48a1d9b7ed403a0b1aaa260 1098 SUPERFAMILY SSF52540 210 396 1.82E-6 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS02895 9cbda617d48a1d9b7ed403a0b1aaa260 1098 Pfam PF05729 NACHT domain 211 381 8.7E-7 T 09-03-2017 TK78_RS09045 815095b12bf2f466705a72ee0d214404 447 Pfam PF02222 ATP-grasp domain 200 326 3.7E-7 T 09-03-2017 IPR003135 ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type TK78_RS09045 815095b12bf2f466705a72ee0d214404 447 Gene3D G3DSA:3.30.470.20 160 431 8.0E-14 T 09-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 TK78_RS09045 815095b12bf2f466705a72ee0d214404 447 SUPERFAMILY SSF56059 161 349 2.65E-23 T 09-03-2017 TK78_RS01885 54719faf1c33c3629fa04b37e17ea132 318 SUPERFAMILY SSF53474 29 316 5.6E-65 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS01885 54719faf1c33c3629fa04b37e17ea132 318 Pfam PF07859 alpha/beta hydrolase fold 83 290 9.6E-60 T 09-03-2017 IPR013094 Alpha/beta hydrolase fold-3 GO:0008152|GO:0016787 TK78_RS01885 54719faf1c33c3629fa04b37e17ea132 318 Gene3D G3DSA:3.40.50.1820 5 315 6.8E-85 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS12580 183ff916c39f2c5446970f83c03e6472 812 Gene3D G3DSA:1.10.486.10 456 611 2.7E-47 T 09-03-2017 TK78_RS12580 183ff916c39f2c5446970f83c03e6472 812 TIGRFAM TIGR01073 pcrA: ATP-dependent DNA helicase PcrA 66 810 0.0 T 09-03-2017 IPR005751 ATP-dependent DNA helicase PcrA GO:0004003|GO:0005737|GO:0006268 TK78_RS12580 183ff916c39f2c5446970f83c03e6472 812 Gene3D G3DSA:3.40.50.300 353 455 9.4E-71 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS12580 183ff916c39f2c5446970f83c03e6472 812 Gene3D G3DSA:3.40.50.300 626 717 9.4E-71 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS12580 183ff916c39f2c5446970f83c03e6472 812 Gene3D G3DSA:3.40.50.300 252 352 2.2E-72 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS12580 183ff916c39f2c5446970f83c03e6472 812 Gene3D G3DSA:3.40.50.300 66 170 2.2E-72 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS12580 183ff916c39f2c5446970f83c03e6472 812 Pfam PF00580 UvrD/REP helicase N-terminal domain 70 338 3.2E-77 T 09-03-2017 IPR014016 UvrD-like Helicase, ATP-binding domain GO:0005524 TK78_RS12580 183ff916c39f2c5446970f83c03e6472 812 Gene3D G3DSA:1.10.10.160 174 251 2.5E-24 T 09-03-2017 IPR013986 DExx box DNA helicase domain TK78_RS12580 183ff916c39f2c5446970f83c03e6472 812 SUPERFAMILY SSF52540 67 716 2.92E-178 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS12580 183ff916c39f2c5446970f83c03e6472 812 Pfam PF13361 UvrD-like helicase C-terminal domain 344 687 8.3E-68 T 09-03-2017 IPR014017 UvrD-like DNA helicase, C-terminal GO:0005524|GO:0016787 TK78_RS07065 2dbe713e9835d60dc72d9f06f458b123 79 ProSitePatterns PS00012 Phosphopantetheine attachment site. 31 46 - T 09-03-2017 IPR006162 Phosphopantetheine attachment site TK78_RS07065 2dbe713e9835d60dc72d9f06f458b123 79 Gene3D G3DSA:1.10.1200.10 5 77 2.5E-14 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS07065 2dbe713e9835d60dc72d9f06f458b123 79 Pfam PF00550 Phosphopantetheine attachment site 19 70 7.9E-8 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS07065 2dbe713e9835d60dc72d9f06f458b123 79 SUPERFAMILY SSF47336 5 77 6.28E-14 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS06840 831530cee56245cdb653a7f472866abc 254 SUPERFAMILY SSF55729 63 251 6.06E-24 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS06840 831530cee56245cdb653a7f472866abc 254 Pfam PF00583 Acetyltransferase (GNAT) family 167 242 1.0E-4 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS06840 831530cee56245cdb653a7f472866abc 254 Gene3D G3DSA:3.40.630.30 116 249 5.1E-18 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS14825 5073384047ea2a0848e347f9b51be513 522 Gene3D G3DSA:3.30.1360.60 7 85 6.5E-23 T 09-03-2017 IPR001996 Phosphotransferase system, IIB component, type 1 GO:0008982|GO:0009401 TK78_RS14825 5073384047ea2a0848e347f9b51be513 522 Pfam PF02378 Phosphotransferase system, EIIC 135 403 1.8E-27 T 09-03-2017 IPR003352 Phosphotransferase system, EIIC GO:0008982|GO:0009401|GO:0016020 TK78_RS14825 5073384047ea2a0848e347f9b51be513 522 Pfam PF00367 phosphotransferase system, EIIB 13 45 2.9E-13 T 09-03-2017 IPR018113 Phosphotransferase system EIIB, cysteine phosphorylation site GO:0008982 TK78_RS14825 5073384047ea2a0848e347f9b51be513 522 SUPERFAMILY SSF55604 11 83 5.75E-17 T 09-03-2017 IPR001996 Phosphotransferase system, IIB component, type 1 GO:0008982|GO:0009401 TK78_RS14825 5073384047ea2a0848e347f9b51be513 522 ProSitePatterns PS01035 PTS EIIB domains cysteine phosphorylation site signature. 23 40 - T 09-03-2017 IPR018113 Phosphotransferase system EIIB, cysteine phosphorylation site GO:0008982 TK78_RS27305 8aeccf66cae652a10d75401173406681 424 SUPERFAMILY SSF103473 14 414 8.76E-39 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS27305 8aeccf66cae652a10d75401173406681 424 Gene3D G3DSA:1.20.1250.20 10 202 1.1E-16 T 09-03-2017 TK78_RS27305 8aeccf66cae652a10d75401173406681 424 Gene3D G3DSA:1.20.1250.20 237 413 7.9E-9 T 09-03-2017 TK78_RS27305 8aeccf66cae652a10d75401173406681 424 Pfam PF07690 Major Facilitator Superfamily 25 377 2.7E-23 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS15535 7071dec9f84a2951b584c86e403dbe9b 449 Pfam PF01580 FtsK/SpoIIIE family 276 331 2.2E-7 T 09-03-2017 IPR002543 FtsK domain GO:0000166|GO:0003677|GO:0005524 TK78_RS15535 7071dec9f84a2951b584c86e403dbe9b 449 Pfam PF01580 FtsK/SpoIIIE family 165 268 1.8E-15 T 09-03-2017 IPR002543 FtsK domain GO:0000166|GO:0003677|GO:0005524 TK78_RS15535 7071dec9f84a2951b584c86e403dbe9b 449 SUPERFAMILY SSF52540 154 373 2.39E-19 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15535 7071dec9f84a2951b584c86e403dbe9b 449 Gene3D G3DSA:3.40.50.300 161 369 1.5E-19 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS30925 64fb5deb96bf9ff73e2b2753467f0647 341 Pfam PF00892 EamA-like transporter family 13 142 3.2E-14 T 09-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 TK78_RS30925 64fb5deb96bf9ff73e2b2753467f0647 341 Pfam PF00892 EamA-like transporter family 154 304 5.0E-13 T 09-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 TK78_RS30925 64fb5deb96bf9ff73e2b2753467f0647 341 SUPERFAMILY SSF103481 230 306 1.7E-10 T 09-03-2017 TK78_RS30925 64fb5deb96bf9ff73e2b2753467f0647 341 SUPERFAMILY SSF103481 47 143 2.75E-10 T 09-03-2017 TK78_RS14280 63d73a91de9bad8aa91c665180a46022 420 SUPERFAMILY SSF48264 14 406 9.95E-54 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS14280 63d73a91de9bad8aa91c665180a46022 420 PRINTS PR00359 B-class P450 signature 342 351 1.1E-19 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS14280 63d73a91de9bad8aa91c665180a46022 420 PRINTS PR00359 B-class P450 signature 148 164 1.1E-19 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS14280 63d73a91de9bad8aa91c665180a46022 420 PRINTS PR00359 B-class P450 signature 199 221 1.1E-19 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS14280 63d73a91de9bad8aa91c665180a46022 420 PRINTS PR00359 B-class P450 signature 295 322 1.1E-19 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS14280 63d73a91de9bad8aa91c665180a46022 420 Gene3D G3DSA:1.10.630.10 13 406 1.1E-78 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS14570 57eb507d3fbd49c66c81ad4fe13fbcbe 278 Gene3D G3DSA:1.20.144.10 60 239 8.5E-32 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS14570 57eb507d3fbd49c66c81ad4fe13fbcbe 278 SMART SM00014 119 234 8.7E-18 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS14570 57eb507d3fbd49c66c81ad4fe13fbcbe 278 Pfam PF01569 PAP2 superfamily 125 239 5.2E-19 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS14570 57eb507d3fbd49c66c81ad4fe13fbcbe 278 SUPERFAMILY SSF48317 44 243 1.18E-34 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS07700 0428b2dbac5c8616b936cde9ea30f855 113 Gene3D G3DSA:1.10.287.1060 1 94 1.8E-8 T 09-03-2017 TK78_RS07700 0428b2dbac5c8616b936cde9ea30f855 113 SUPERFAMILY SSF140453 5 95 2.09E-11 T 09-03-2017 IPR010310 Type VII secretion system ESAT-6-like TK78_RS07700 0428b2dbac5c8616b936cde9ea30f855 113 Pfam PF06013 Proteins of 100 residues with WXG 22 81 6.0E-9 T 09-03-2017 IPR010310 Type VII secretion system ESAT-6-like TK78_RS14885 613230ebd9ed989b6b0fdaf412f3b927 476 SUPERFAMILY SSF51445 24 473 2.86E-153 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS14885 613230ebd9ed989b6b0fdaf412f3b927 476 TIGRFAM TIGR03356 BGL: beta-galactosidase 25 464 2.2E-181 T 09-03-2017 IPR017736 Glycoside hydrolase, family 1, beta-glucosidase GO:0008422|GO:0030245 KEGG: 00460+3.2.1.21|KEGG: 00500+3.2.1.21|KEGG: 00940+3.2.1.21|MetaCyc: PWY-3121|MetaCyc: PWY-5176|MetaCyc: PWY-6002|MetaCyc: PWY-6788|MetaCyc: PWY-7089|MetaCyc: PWY-7091|MetaCyc: PWY-7092 TK78_RS14885 613230ebd9ed989b6b0fdaf412f3b927 476 Pfam PF00232 Glycosyl hydrolase family 1 24 469 5.3E-155 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS14885 613230ebd9ed989b6b0fdaf412f3b927 476 PRINTS PR00131 Glycosyl hydrolase family 1 signature 376 384 1.4E-20 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS14885 613230ebd9ed989b6b0fdaf412f3b927 476 PRINTS PR00131 Glycosyl hydrolase family 1 signature 307 321 1.4E-20 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS14885 613230ebd9ed989b6b0fdaf412f3b927 476 PRINTS PR00131 Glycosyl hydrolase family 1 signature 418 435 1.4E-20 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS14885 613230ebd9ed989b6b0fdaf412f3b927 476 PRINTS PR00131 Glycosyl hydrolase family 1 signature 442 454 1.4E-20 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS14885 613230ebd9ed989b6b0fdaf412f3b927 476 PRINTS PR00131 Glycosyl hydrolase family 1 signature 397 408 1.4E-20 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS14885 613230ebd9ed989b6b0fdaf412f3b927 476 Gene3D G3DSA:3.20.20.80 24 473 1.1E-153 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS14885 613230ebd9ed989b6b0fdaf412f3b927 476 ProSitePatterns PS00572 Glycosyl hydrolases family 1 active site. 376 384 - T 09-03-2017 IPR018120 Glycoside hydrolase family 1, active site TK78_RS14885 613230ebd9ed989b6b0fdaf412f3b927 476 ProSitePatterns PS00653 Glycosyl hydrolases family 1 N-terminal signature. 29 43 - T 09-03-2017 IPR033132 Glycosyl hydrolases family 1, N-terminal conserved site TK78_RS33490 ee70008b0f25a46fd2ec9df122f1541b 602 Pfam PF00578 AhpC/TSA family 322 430 6.4E-12 T 09-03-2017 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15|Reactome: R-HSA-3299685 TK78_RS33490 ee70008b0f25a46fd2ec9df122f1541b 602 Gene3D G3DSA:2.60.120.260 473 601 1.4E-34 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS33490 ee70008b0f25a46fd2ec9df122f1541b 602 SUPERFAMILY SSF52833 319 449 2.18E-33 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS33490 ee70008b0f25a46fd2ec9df122f1541b 602 Gene3D G3DSA:3.40.30.10 301 453 7.9E-47 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS33490 ee70008b0f25a46fd2ec9df122f1541b 602 Pfam PF02683 Cytochrome C biogenesis protein transmembrane region 88 246 1.5E-14 T 09-03-2017 IPR003834 Cytochrome C biogenesis protein, transmembrane domain GO:0016020|GO:0017004|GO:0055114 TK78_RS13535 42fa801cb3c115ff6ccb7b338bdc8eb1 298 Pfam PF12730 ABC-2 family transporter protein 24 199 8.0E-13 T 09-03-2017 IPR032688 ABC-2 family transporter protein GO:0006810 TK78_RS19865 f8645191b1257d50e87701873306d92f 663 Gene3D G3DSA:2.60.40.360 485 549 7.8E-4 T 09-03-2017 IPR008962 PapD-like TK78_RS07950 d49c9078b8dc49ec71f9a102bded5ebd 415 Gene3D G3DSA:3.40.190.10 200 361 7.3E-41 T 09-03-2017 TK78_RS07950 d49c9078b8dc49ec71f9a102bded5ebd 415 Pfam PF13416 Bacterial extracellular solute-binding protein 99 366 1.1E-27 T 09-03-2017 TK78_RS07950 d49c9078b8dc49ec71f9a102bded5ebd 415 PRINTS PR00909 Bacterial periplasmic spermidine/putrescine-binding protein signature 152 165 4.4E-10 T 09-03-2017 IPR001188 Bacterial periplasmic spermidine/putrescine-binding protein GO:0015846|GO:0019808|GO:0042597 TK78_RS07950 d49c9078b8dc49ec71f9a102bded5ebd 415 PRINTS PR00909 Bacterial periplasmic spermidine/putrescine-binding protein signature 229 248 4.4E-10 T 09-03-2017 IPR001188 Bacterial periplasmic spermidine/putrescine-binding protein GO:0015846|GO:0019808|GO:0042597 TK78_RS07950 d49c9078b8dc49ec71f9a102bded5ebd 415 PRINTS PR00909 Bacterial periplasmic spermidine/putrescine-binding protein signature 136 150 4.4E-10 T 09-03-2017 IPR001188 Bacterial periplasmic spermidine/putrescine-binding protein GO:0015846|GO:0019808|GO:0042597 TK78_RS07950 d49c9078b8dc49ec71f9a102bded5ebd 415 PRINTS PR00909 Bacterial periplasmic spermidine/putrescine-binding protein signature 184 200 4.4E-10 T 09-03-2017 IPR001188 Bacterial periplasmic spermidine/putrescine-binding protein GO:0015846|GO:0019808|GO:0042597 TK78_RS07950 d49c9078b8dc49ec71f9a102bded5ebd 415 PRINTS PR00909 Bacterial periplasmic spermidine/putrescine-binding protein signature 312 331 4.4E-10 T 09-03-2017 IPR001188 Bacterial periplasmic spermidine/putrescine-binding protein GO:0015846|GO:0019808|GO:0042597 TK78_RS07950 d49c9078b8dc49ec71f9a102bded5ebd 415 PRINTS PR00909 Bacterial periplasmic spermidine/putrescine-binding protein signature 268 287 4.4E-10 T 09-03-2017 IPR001188 Bacterial periplasmic spermidine/putrescine-binding protein GO:0015846|GO:0019808|GO:0042597 TK78_RS07950 d49c9078b8dc49ec71f9a102bded5ebd 415 SUPERFAMILY SSF53850 74 412 3.0E-59 T 09-03-2017 TK78_RS07950 d49c9078b8dc49ec71f9a102bded5ebd 415 Gene3D G3DSA:3.40.190.10 76 199 6.1E-9 T 09-03-2017 TK78_RS07705 911c4d082954f7930bcddb851b383271 413 Pfam PF00082 Subtilase family 60 300 7.1E-35 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS07705 911c4d082954f7930bcddb851b383271 413 SUPERFAMILY SSF52743 42 318 1.83E-61 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS07705 911c4d082954f7930bcddb851b383271 413 Gene3D G3DSA:3.40.50.200 38 319 1.1E-65 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS07705 911c4d082954f7930bcddb851b383271 413 PRINTS PR00723 Subtilisin serine protease family (S8) signature 60 79 1.0E-11 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS07705 911c4d082954f7930bcddb851b383271 413 PRINTS PR00723 Subtilisin serine protease family (S8) signature 262 278 1.0E-11 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS07705 911c4d082954f7930bcddb851b383271 413 PRINTS PR00723 Subtilisin serine protease family (S8) signature 99 112 1.0E-11 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS23570 ac34d246a9f720257240d1818e92d3e5 197 SUPERFAMILY SSF55729 23 192 1.95E-37 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS23570 ac34d246a9f720257240d1818e92d3e5 197 Pfam PF13302 Acetyltransferase (GNAT) domain 31 167 1.0E-25 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS23570 ac34d246a9f720257240d1818e92d3e5 197 Gene3D G3DSA:3.40.630.30 20 192 1.1E-42 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS07280 bcab21ba65fc6fbd5daf2147275b7d85 252 ProSitePatterns PS00893 Nudix box signature. 49 70 - T 09-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 TK78_RS07280 bcab21ba65fc6fbd5daf2147275b7d85 252 SUPERFAMILY SSF46785 175 244 5.71E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS07280 bcab21ba65fc6fbd5daf2147275b7d85 252 Gene3D G3DSA:1.10.10.10 167 239 1.7E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS07280 bcab21ba65fc6fbd5daf2147275b7d85 252 Pfam PF00293 NUDIX domain 15 139 3.1E-17 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS07280 bcab21ba65fc6fbd5daf2147275b7d85 252 Gene3D G3DSA:3.90.79.10 3 163 1.6E-46 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS07280 bcab21ba65fc6fbd5daf2147275b7d85 252 SUPERFAMILY SSF55811 8 170 5.82E-27 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS21380 bb5b2d539f8af68733136c14f1c09465 166 Pfam PF14433 SUKH-3 immunity protein 13 157 5.3E-47 T 09-03-2017 IPR025850 SUKH-3 immunity protein TK78_RS33290 ac28d65b2939a71e9a9d9c8ae4a2718d 208 Pfam PF12840 Helix-turn-helix domain 18 68 2.0E-10 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS33290 ac28d65b2939a71e9a9d9c8ae4a2718d 208 Gene3D G3DSA:1.10.10.10 17 75 9.2E-13 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS33290 ac28d65b2939a71e9a9d9c8ae4a2718d 208 SUPERFAMILY SSF46785 15 130 4.85E-14 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS33290 ac28d65b2939a71e9a9d9c8ae4a2718d 208 SMART SM00418 17 97 4.3E-5 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS14820 968bc139622144ca505e91e22e8ecfca 329 ProSitePatterns PS01272 Glucokinase regulatory protein family signature. 213 230 - T 09-03-2017 IPR005486 Glucokinase regulatory protein, conserved site KEGG: 00030+4.2.1.12|KEGG: 00520+4.2.1.126|Reactome: R-HSA-170822|Reactome: R-HSA-5619107 TK78_RS14820 968bc139622144ca505e91e22e8ecfca 329 SUPERFAMILY SSF53697 34 275 1.9E-66 T 09-03-2017 TK78_RS14820 968bc139622144ca505e91e22e8ecfca 329 Pfam PF01380 SIS domain 156 235 2.9E-10 T 09-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 TK78_RS14820 968bc139622144ca505e91e22e8ecfca 329 Hamap MF_00068 N-acetylmuramic acid 6-phosphate etherase [murQ]. 30 323 41.56 T 09-03-2017 IPR005488 N-acetylmuramic acid 6-phosphate etherase MurQ GO:0016835|GO:0046348 KEGG: 00030+4.2.1.12|KEGG: 00520+4.2.1.126 TK78_RS14820 968bc139622144ca505e91e22e8ecfca 329 Gene3D G3DSA:3.40.50.10490 28 277 1.0E-81 T 09-03-2017 TK78_RS14820 968bc139622144ca505e91e22e8ecfca 329 TIGRFAM TIGR00274 TIGR00274: N-acetylmuramic acid 6-phosphate etherase 34 323 1.6E-111 T 09-03-2017 IPR005488 N-acetylmuramic acid 6-phosphate etherase MurQ GO:0016835|GO:0046348 KEGG: 00030+4.2.1.12|KEGG: 00520+4.2.1.126 TK78_RS00730 50c02e2527a0c4350a9a2f2127f38613 254 SMART SM00062 19 240 1.4E-26 T 09-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF TK78_RS00730 50c02e2527a0c4350a9a2f2127f38613 254 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3 33 236 1.8E-23 T 09-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF TK78_RS00730 50c02e2527a0c4350a9a2f2127f38613 254 Gene3D G3DSA:3.40.190.10 98 193 1.9E-5 T 09-03-2017 TK78_RS00730 50c02e2527a0c4350a9a2f2127f38613 254 Gene3D G3DSA:3.40.190.10 20 97 7.5E-12 T 09-03-2017 TK78_RS00730 50c02e2527a0c4350a9a2f2127f38613 254 Gene3D G3DSA:3.40.190.10 198 237 7.5E-12 T 09-03-2017 TK78_RS00730 50c02e2527a0c4350a9a2f2127f38613 254 SUPERFAMILY SSF53850 23 237 1.45E-28 T 09-03-2017 TK78_RS24005 9962251a67a621a516c19f00f791547b 490 Gene3D G3DSA:2.130.10.130 42 173 7.2E-23 T 09-03-2017 TK78_RS24005 9962251a67a621a516c19f00f791547b 490 Gene3D G3DSA:2.130.10.130 174 377 1.1E-21 T 09-03-2017 TK78_RS24005 9962251a67a621a516c19f00f791547b 490 SMART SM00191 162 255 59.0 T 09-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 TK78_RS24005 9962251a67a621a516c19f00f791547b 490 SMART SM00191 38 91 220.0 T 09-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 TK78_RS24005 9962251a67a621a516c19f00f791547b 490 SMART SM00191 101 159 0.008 T 09-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 TK78_RS24005 9962251a67a621a516c19f00f791547b 490 SMART SM00191 347 407 2.0E-5 T 09-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 TK78_RS24005 9962251a67a621a516c19f00f791547b 490 SMART SM00191 271 335 200.0 T 09-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 TK78_RS24005 9962251a67a621a516c19f00f791547b 490 SMART SM00191 417 471 3.8E-7 T 09-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 TK78_RS24005 9962251a67a621a516c19f00f791547b 490 Pfam PF01839 FG-GAP repeat 421 454 2.3E-7 T 09-03-2017 IPR013517 FG-GAP repeat Reactome: R-HSA-216083 TK78_RS24005 9962251a67a621a516c19f00f791547b 490 Pfam PF01839 FG-GAP repeat 167 187 3.2E-5 T 09-03-2017 IPR013517 FG-GAP repeat Reactome: R-HSA-216083 TK78_RS24005 9962251a67a621a516c19f00f791547b 490 Pfam PF01839 FG-GAP repeat 351 380 5.7E-7 T 09-03-2017 IPR013517 FG-GAP repeat Reactome: R-HSA-216083 TK78_RS24005 9962251a67a621a516c19f00f791547b 490 PRINTS PR01185 Integrin alpha subunit signature 419 443 4.8E-6 T 09-03-2017 IPR000413 Integrin alpha chain GO:0007155|GO:0008305 Reactome: R-HSA-216083 TK78_RS24005 9962251a67a621a516c19f00f791547b 490 PRINTS PR01185 Integrin alpha subunit signature 344 364 4.8E-6 T 09-03-2017 IPR000413 Integrin alpha chain GO:0007155|GO:0008305 Reactome: R-HSA-216083 TK78_RS24005 9962251a67a621a516c19f00f791547b 490 Pfam PF13517 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella 43 124 5.8E-9 T 09-03-2017 TK78_RS24005 9962251a67a621a516c19f00f791547b 490 SUPERFAMILY SSF69318 42 446 1.31E-57 T 09-03-2017 TK78_RS19530 8711e01923388b51a805bcfd2c4c8803 287 Gene3D G3DSA:1.10.260.40 15 69 3.2E-6 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS19530 8711e01923388b51a805bcfd2c4c8803 287 SMART SM00530 19 74 6.1E-4 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS19530 8711e01923388b51a805bcfd2c4c8803 287 Pfam PF13560 Helix-turn-helix domain 16 78 1.4E-13 T 09-03-2017 TK78_RS19530 8711e01923388b51a805bcfd2c4c8803 287 SUPERFAMILY SSF47413 13 69 1.6E-6 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS15395 dbf30ee0233e2b5904312e213392bc2e 179 Pfam PF07332 Putative Actinobacterial Holin-X, holin superfamily III 16 130 6.1E-33 T 09-03-2017 IPR009937 Putative Actinobacterial Holin-X, holin superfamily III TK78_RS15395 dbf30ee0233e2b5904312e213392bc2e 179 Gene3D G3DSA:1.20.1250.20 46 113 6.1E-6 T 09-03-2017 TK78_RS32165 18cc1bcf566f5f2f94a4654e102adc73 505 ProSitePatterns PS00933 FGGY family of carbohydrate kinases signature 1. 134 146 - T 09-03-2017 IPR018483 Carbohydrate kinase, FGGY, conserved site GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 TK78_RS32165 18cc1bcf566f5f2f94a4654e102adc73 505 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 5 256 1.6E-70 T 09-03-2017 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 TK78_RS32165 18cc1bcf566f5f2f94a4654e102adc73 505 PIRSF PIRSF000538 2 504 6.8E-157 T 09-03-2017 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 TK78_RS32165 18cc1bcf566f5f2f94a4654e102adc73 505 SUPERFAMILY SSF53067 259 502 1.6E-81 T 09-03-2017 TK78_RS32165 18cc1bcf566f5f2f94a4654e102adc73 505 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 265 455 3.1E-63 T 09-03-2017 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 TK78_RS32165 18cc1bcf566f5f2f94a4654e102adc73 505 SUPERFAMILY SSF53067 4 259 1.85E-82 T 09-03-2017 TK78_RS32165 18cc1bcf566f5f2f94a4654e102adc73 505 TIGRFAM TIGR01311 glycerol_kin: glycerol kinase 4 501 7.1E-221 T 09-03-2017 IPR005999 Glycerol kinase GO:0004370|GO:0006072 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|Reactome: R-HSA-75109 TK78_RS32165 18cc1bcf566f5f2f94a4654e102adc73 505 Gene3D G3DSA:3.30.420.40 259 503 1.2E-100 T 09-03-2017 TK78_RS32165 18cc1bcf566f5f2f94a4654e102adc73 505 Gene3D G3DSA:3.30.420.40 2 257 1.8E-97 T 09-03-2017 TK78_RS32165 18cc1bcf566f5f2f94a4654e102adc73 505 Hamap MF_00186 Glycerol kinase [glpK]. 2 502 54.359 T 09-03-2017 IPR005999 Glycerol kinase GO:0004370|GO:0006072 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|Reactome: R-HSA-75109 TK78_RS32165 18cc1bcf566f5f2f94a4654e102adc73 505 ProSitePatterns PS00445 FGGY family of carbohydrate kinases signature 2. 367 387 - T 09-03-2017 IPR018483 Carbohydrate kinase, FGGY, conserved site GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 TK78_RS14755 1297cc9c526413244d9b8973ad61fa5c 696 SUPERFAMILY SSF52540 183 321 4.8E-41 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS14755 1297cc9c526413244d9b8973ad61fa5c 696 SUPERFAMILY SSF52540 440 688 4.8E-41 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS14755 1297cc9c526413244d9b8973ad61fa5c 696 Pfam PF13245 Part of AAA domain 199 262 4.3E-13 T 09-03-2017 TK78_RS14755 1297cc9c526413244d9b8973ad61fa5c 696 Gene3D G3DSA:3.40.50.300 528 691 1.3E-21 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS14755 1297cc9c526413244d9b8973ad61fa5c 696 Gene3D G3DSA:3.40.50.300 190 252 9.0E-32 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS14755 1297cc9c526413244d9b8973ad61fa5c 696 Gene3D G3DSA:3.40.50.300 388 524 9.0E-32 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS14755 1297cc9c526413244d9b8973ad61fa5c 696 Pfam PF13538 UvrD-like helicase C-terminal domain 640 683 1.5E-6 T 09-03-2017 IPR027785 UvrD-like helicase C-terminal domain TK78_RS23095 33172f3e5653000d69c0f1a5c2e3541d 341 Gene3D G3DSA:3.40.50.720 5 108 7.1E-5 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS23095 33172f3e5653000d69c0f1a5c2e3541d 341 SUPERFAMILY SSF51735 101 273 5.72E-44 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS23095 33172f3e5653000d69c0f1a5c2e3541d 341 Gene3D G3DSA:3.40.50.720 109 275 1.7E-48 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS23095 33172f3e5653000d69c0f1a5c2e3541d 341 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 107 273 3.3E-42 T 09-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 TK78_RS23095 33172f3e5653000d69c0f1a5c2e3541d 341 SUPERFAMILY SSF52283 5 130 3.63E-6 T 09-03-2017 TK78_RS08575 00cc6dc9bd5c946283465a67b38ca4b7 344 Gene3D G3DSA:1.10.260.40 17 72 8.9E-13 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS08575 00cc6dc9bd5c946283465a67b38ca4b7 344 Pfam PF13560 Helix-turn-helix domain 19 77 1.6E-12 T 09-03-2017 TK78_RS08575 00cc6dc9bd5c946283465a67b38ca4b7 344 SMART SM00530 21 76 9.8E-11 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS08575 00cc6dc9bd5c946283465a67b38ca4b7 344 SUPERFAMILY SSF47413 16 72 5.63E-12 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS34500 472a096ae32e5d505ce8351914b24185 215 TIGRFAM TIGR02258 2_5_ligase: 2'-5' RNA ligase 23 188 1.8E-30 T 09-03-2017 IPR004175 RNA 2',3'-cyclic phosphodiesterase GO:0004113|GO:0008664 TK78_RS34500 472a096ae32e5d505ce8351914b24185 215 Hamap MF_01940 RNA 2',3'-cyclic phosphodiesterase [thpR]. 22 202 19.481 T 09-03-2017 IPR004175 RNA 2',3'-cyclic phosphodiesterase GO:0004113|GO:0008664 TK78_RS34500 472a096ae32e5d505ce8351914b24185 215 Gene3D G3DSA:3.90.1140.10 22 202 2.2E-45 T 09-03-2017 IPR009097 RNA ligase/cyclic nucleotide phosphodiesterase TK78_RS34500 472a096ae32e5d505ce8351914b24185 215 Pfam PF02834 LigT like Phosphoesterase 116 184 1.4E-5 T 09-03-2017 IPR014051 Phosphoesterase, HXTX TK78_RS34500 472a096ae32e5d505ce8351914b24185 215 Pfam PF02834 LigT like Phosphoesterase 29 108 3.2E-11 T 09-03-2017 IPR014051 Phosphoesterase, HXTX TK78_RS34500 472a096ae32e5d505ce8351914b24185 215 SUPERFAMILY SSF55144 23 202 1.52E-32 T 09-03-2017 IPR009097 RNA ligase/cyclic nucleotide phosphodiesterase TK78_RS27920 e95a1d9532cb3958deeccdaebc77e9ce 260 SUPERFAMILY SSF100950 6 255 3.82E-62 T 09-03-2017 TK78_RS27920 e95a1d9532cb3958deeccdaebc77e9ce 260 TIGRFAM TIGR01198 pgl: 6-phosphogluconolactonase 8 249 1.9E-76 T 09-03-2017 IPR005900 6-phosphogluconolactonase, DevB-type GO:0005975|GO:0006098|GO:0017057 KEGG: 00030+3.1.1.31 TK78_RS27920 e95a1d9532cb3958deeccdaebc77e9ce 260 Pfam PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 11 240 1.5E-72 T 09-03-2017 IPR006148 Glucosamine/galactosamine-6-phosphate isomerase GO:0005975 KEGG: 00520+3.5.99.6|MetaCyc: PWY-5514|MetaCyc: PWY-6855|MetaCyc: PWY-6906 TK78_RS27920 e95a1d9532cb3958deeccdaebc77e9ce 260 Gene3D G3DSA:3.40.50.1360 5 250 2.1E-73 T 09-03-2017 TK78_RS09340 51fd7e86e7d00364bb74332ad547e22a 672 SUPERFAMILY SSF51445 194 569 4.47E-81 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS09340 51fd7e86e7d00364bb74332ad547e22a 672 Gene3D G3DSA:3.20.20.80 158 567 8.4E-70 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS09340 51fd7e86e7d00364bb74332ad547e22a 672 Gene3D G3DSA:3.20.20.80 62 98 8.4E-70 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS09340 51fd7e86e7d00364bb74332ad547e22a 672 SMART SM00642 196 562 3.7E-4 T 09-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 TK78_RS09340 51fd7e86e7d00364bb74332ad547e22a 672 Gene3D G3DSA:2.60.40.1180 573 650 1.7E-12 T 09-03-2017 IPR013780 Glycosyl hydrolase, all-beta TK78_RS09340 51fd7e86e7d00364bb74332ad547e22a 672 Pfam PF11896 Domain of unknown function (DUF3416) 3 190 8.3E-62 T 09-03-2017 IPR021828 Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase, domain N/S GO:0004553 KEGG: 00500+2.4.99.16 TK78_RS09340 51fd7e86e7d00364bb74332ad547e22a 672 Hamap MF_02124 Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase [glgE]. 1 662 46.398 T 09-03-2017 IPR026585 Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase GO:0016757 KEGG: 00500+2.4.99.16 TK78_RS09340 51fd7e86e7d00364bb74332ad547e22a 672 SUPERFAMILY SSF51011 573 650 1.96E-6 T 09-03-2017 TK78_RS27355 39feaaabe4231c2db35c7127d6b08ce0 270 ProSitePatterns PS00167 Tryptophan synthase alpha chain signature. 52 65 - T 09-03-2017 IPR018204 Tryptophan synthase, alpha chain, active site GO:0004834 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 TK78_RS27355 39feaaabe4231c2db35c7127d6b08ce0 270 TIGRFAM TIGR00262 trpA: tryptophan synthase, alpha subunit 15 263 3.0E-68 T 09-03-2017 IPR002028 Tryptophan synthase, alpha chain GO:0004834|GO:0006568 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 TK78_RS27355 39feaaabe4231c2db35c7127d6b08ce0 270 SUPERFAMILY SSF51366 8 249 7.06E-79 T 09-03-2017 IPR011060 Ribulose-phosphate binding barrel GO:0003824|GO:0008152 TK78_RS27355 39feaaabe4231c2db35c7127d6b08ce0 270 Gene3D G3DSA:3.20.20.70 8 269 3.7E-93 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS27355 39feaaabe4231c2db35c7127d6b08ce0 270 Pfam PF00290 Tryptophan synthase alpha chain 13 259 7.8E-78 T 09-03-2017 IPR002028 Tryptophan synthase, alpha chain GO:0004834|GO:0006568 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 TK78_RS27355 39feaaabe4231c2db35c7127d6b08ce0 270 Hamap MF_00131 Tryptophan synthase alpha chain [trpA]. 18 266 34.339 T 09-03-2017 IPR002028 Tryptophan synthase, alpha chain GO:0004834|GO:0006568 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 TK78_RS21285 cb4d27ef367cc21f899be649e3772cf6 332 Gene3D G3DSA:3.90.25.10 179 326 2.1E-42 T 09-03-2017 TK78_RS21285 cb4d27ef367cc21f899be649e3772cf6 332 Pfam PF01370 NAD dependent epimerase/dehydratase family 15 250 6.5E-55 T 09-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 TK78_RS21285 cb4d27ef367cc21f899be649e3772cf6 332 SUPERFAMILY SSF51735 12 325 5.5E-86 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS21285 cb4d27ef367cc21f899be649e3772cf6 332 Gene3D G3DSA:3.40.50.720 11 178 8.2E-46 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS21285 cb4d27ef367cc21f899be649e3772cf6 332 TIGRFAM TIGR01179 galE: UDP-glucose 4-epimerase GalE 14 327 1.1E-112 T 09-03-2017 IPR005886 UDP-glucose 4-epimerase GalE GO:0003978|GO:0006012 KEGG: 00052+5.1.3.2|KEGG: 00520+5.1.3.2|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6397|MetaCyc: PWY-6527|MetaCyc: PWY-7328|MetaCyc: PWY-7344|Reactome: R-HSA-5609977|Reactome: R-HSA-70370 TK78_RS12035 6cc6dcf7e30c1311fc701bf0027b1944 274 ProSitePatterns PS01240 Purine and other phosphorylases family 2 signature. 89 130 - T 09-03-2017 IPR018099 Purine phosphorylase, family 2, conserved site GO:0016763 TK78_RS12035 6cc6dcf7e30c1311fc701bf0027b1944 274 Gene3D G3DSA:3.40.50.1580 18 273 2.8E-89 T 09-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 TK78_RS12035 6cc6dcf7e30c1311fc701bf0027b1944 274 TIGRFAM TIGR01698 PUNP: purine nucleotide phosphorylase 35 270 1.3E-98 T 09-03-2017 IPR011269 Putative purine nucleotide phosphorylase GO:0004731|GO:0006139 KEGG: 00230+2.4.2.1|KEGG: 00240+2.4.2.1|KEGG: 00760+2.4.2.1|MetaCyc: PWY-4202|MetaCyc: PWY-5695|MetaCyc: PWY-6608|MetaCyc: PWY-6609|MetaCyc: PWY-6611|MetaCyc: PWY-6620|MetaCyc: PWY-6627|MetaCyc: PWY-6644|MetaCyc: PWY-7179|MetaCyc: PWY-7179-1 TK78_RS12035 6cc6dcf7e30c1311fc701bf0027b1944 274 TIGRFAM TIGR01697 PNPH-PUNA-XAPA: inosine/guanosine/xanthosine phosphorylase family 35 271 5.4E-75 T 09-03-2017 IPR011268 Purine nucleoside phosphorylase GO:0004731|GO:0006139 KEGG: 00230+2.4.2.1|KEGG: 00240+2.4.2.1|KEGG: 00760+2.4.2.1|MetaCyc: PWY-4202|MetaCyc: PWY-5695|MetaCyc: PWY-6608|MetaCyc: PWY-6609|MetaCyc: PWY-6611|MetaCyc: PWY-6620|MetaCyc: PWY-6627|MetaCyc: PWY-6644|MetaCyc: PWY-7179|MetaCyc: PWY-7179-1|Reactome: R-HSA-74217|Reactome: R-HSA-74259 TK78_RS12035 6cc6dcf7e30c1311fc701bf0027b1944 274 SUPERFAMILY SSF53167 21 274 1.81E-78 T 09-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 TK78_RS12035 6cc6dcf7e30c1311fc701bf0027b1944 274 PIRSF PIRSF000477 8 274 7.6E-87 T 09-03-2017 IPR011268 Purine nucleoside phosphorylase GO:0004731|GO:0006139 KEGG: 00230+2.4.2.1|KEGG: 00240+2.4.2.1|KEGG: 00760+2.4.2.1|MetaCyc: PWY-4202|MetaCyc: PWY-5695|MetaCyc: PWY-6608|MetaCyc: PWY-6609|MetaCyc: PWY-6611|MetaCyc: PWY-6620|MetaCyc: PWY-6627|MetaCyc: PWY-6644|MetaCyc: PWY-7179|MetaCyc: PWY-7179-1|Reactome: R-HSA-74217|Reactome: R-HSA-74259 TK78_RS12035 6cc6dcf7e30c1311fc701bf0027b1944 274 Pfam PF01048 Phosphorylase superfamily 36 271 1.0E-39 T 09-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 TK78_RS11330 63e1047416f93e1474b38c4ea4ff5523 1166 Pfam PF00931 NB-ARC domain 247 370 6.6E-6 T 09-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 TK78_RS11330 63e1047416f93e1474b38c4ea4ff5523 1166 SUPERFAMILY SSF52540 231 437 9.74E-16 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15475 8f398123c1d8d90dc1dd3840350fad75 312 Pfam PF12850 Calcineurin-like phosphoesterase superfamily domain 52 243 2.1E-6 T 09-03-2017 IPR024654 Calcineurin-like phosphoesterase domain, lpxH type Reactome: R-HSA-3238698 TK78_RS15475 8f398123c1d8d90dc1dd3840350fad75 312 SUPERFAMILY SSF56300 45 305 2.47E-26 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS15475 8f398123c1d8d90dc1dd3840350fad75 312 Gene3D G3DSA:3.60.21.10 153 256 4.7E-11 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS15475 8f398123c1d8d90dc1dd3840350fad75 312 Gene3D G3DSA:3.60.21.10 50 120 4.7E-11 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS29735 7e1f0a6454f60d570f3e5b01e7824bfc 263 Pfam PF03466 LysR substrate binding domain 22 194 5.7E-25 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS29735 7e1f0a6454f60d570f3e5b01e7824bfc 263 Gene3D G3DSA:3.40.190.10 22 88 9.3E-13 T 09-03-2017 TK78_RS29735 7e1f0a6454f60d570f3e5b01e7824bfc 263 Gene3D G3DSA:3.40.190.10 89 167 1.8E-9 T 09-03-2017 TK78_RS29735 7e1f0a6454f60d570f3e5b01e7824bfc 263 SUPERFAMILY SSF53850 10 196 1.23E-23 T 09-03-2017 TK78_RS23440 475261af7050aabdaaa98e115d8de9a6 220 Gene3D G3DSA:3.40.190.10 15 75 6.9E-4 T 09-03-2017 TK78_RS28820 cc93bca53252907ac51815e13cb2adcc 250 Gene3D G3DSA:3.40.50.300 1 247 9.0E-84 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28820 cc93bca53252907ac51815e13cb2adcc 250 SMART SM00382 26 223 8.5E-17 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS28820 cc93bca53252907ac51815e13cb2adcc 250 ProSitePatterns PS00211 ABC transporters family signature. 147 161 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS28820 cc93bca53252907ac51815e13cb2adcc 250 SUPERFAMILY SSF52540 1 245 2.35E-77 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS28820 cc93bca53252907ac51815e13cb2adcc 250 PIRSF PIRSF039085 1 250 9.1E-116 T 09-03-2017 IPR030679 ABC-type amino acid transport system, ATPase component, HisP-type GO:0003333|GO:0015424 TK78_RS28820 cc93bca53252907ac51815e13cb2adcc 250 Pfam PF00005 ABC transporter 17 175 6.7E-34 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS23915 0169b01ad78c2cfdc969567e64cdce89 63 Pfam PF13411 MerR HTH family regulatory protein 9 48 9.7E-5 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS23915 0169b01ad78c2cfdc969567e64cdce89 63 SUPERFAMILY SSF46955 7 57 4.44E-7 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS23915 0169b01ad78c2cfdc969567e64cdce89 63 Gene3D G3DSA:1.10.1660.10 10 42 1.5E-5 T 09-03-2017 TK78_RS06740 7f040ceaa4bafe061444372d5d8d0ea4 449 Gene3D G3DSA:3.90.1150.10 305 428 4.5E-10 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS06740 7f040ceaa4bafe061444372d5d8d0ea4 449 SUPERFAMILY SSF53383 33 430 8.16E-73 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS06740 7f040ceaa4bafe061444372d5d8d0ea4 449 Pfam PF00155 Aminotransferase class I and II 94 424 1.3E-30 T 09-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TK78_RS06740 7f040ceaa4bafe061444372d5d8d0ea4 449 Gene3D G3DSA:3.40.640.10 81 304 1.5E-62 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS29460 ad798398caac0d3f15133cd5ddede0d7 450 SUPERFAMILY SSF53335 155 425 1.25E-69 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS29460 ad798398caac0d3f15133cd5ddede0d7 450 PIRSF PIRSF003085 21 442 5.1E-104 T 09-03-2017 IPR003333 Mycolic acid cyclopropane synthase GO:0008610 TK78_RS29460 ad798398caac0d3f15133cd5ddede0d7 450 Pfam PF02353 Mycolic acid cyclopropane synthetase 145 420 8.5E-73 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS29460 ad798398caac0d3f15133cd5ddede0d7 450 Gene3D G3DSA:3.40.50.150 145 421 5.9E-81 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS29395 ba122e89b6be105d1ea7308f544b72e8 317 Pfam PF13280 WYL domain 148 314 4.7E-32 T 09-03-2017 IPR026881 WYL domain TK78_RS17110 49a857b993e7c1a0b9b38112783ca236 596 Pfam PF01964 Radical SAM ThiC family 139 559 3.5E-199 T 09-03-2017 IPR002817 Phosphomethylpyrimidine synthase GO:0009228|GO:0051536 KEGG: 00730+4.1.99.17|MetaCyc: PWY-6890 TK78_RS17110 49a857b993e7c1a0b9b38112783ca236 596 TIGRFAM TIGR00190 thiC: phosphomethylpyrimidine synthase 138 562 4.5E-212 T 09-03-2017 IPR002817 Phosphomethylpyrimidine synthase GO:0009228|GO:0051536 KEGG: 00730+4.1.99.17|MetaCyc: PWY-6890 TK78_RS17110 49a857b993e7c1a0b9b38112783ca236 596 Pfam PF13667 ThiC-associated domain 29 92 9.5E-22 T 09-03-2017 IPR025747 ThiC-associated domain KEGG: 00730+4.1.99.17|MetaCyc: PWY-6890 TK78_RS17110 49a857b993e7c1a0b9b38112783ca236 596 Hamap MF_00089 Phosphomethylpyrimidine synthase [thiC]. 138 565 55.692 T 09-03-2017 IPR002817 Phosphomethylpyrimidine synthase GO:0009228|GO:0051536 KEGG: 00730+4.1.99.17|MetaCyc: PWY-6890 TK78_RS08445 abba2dfcebbf3ce85d701d4f54422afa 193 Gene3D G3DSA:3.40.50.300 13 186 1.6E-14 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08445 abba2dfcebbf3ce85d701d4f54422afa 193 Pfam PF03029 Conserved hypothetical ATP binding protein 21 187 1.3E-27 T 09-03-2017 IPR004130 GPN-loop GTPase TK78_RS08445 abba2dfcebbf3ce85d701d4f54422afa 193 SUPERFAMILY SSF52540 17 190 5.59E-22 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10800 69bd62c4ec9b57313fb9bd3abddd4734 270 ProSitePatterns PS00166 Enoyl-CoA hydratase/isomerase signature. 111 131 - T 09-03-2017 IPR018376 Enoyl-CoA hydratase/isomerase, conserved site GO:0003824|GO:0008152 TK78_RS10800 69bd62c4ec9b57313fb9bd3abddd4734 270 SUPERFAMILY SSF52096 6 268 8.11E-76 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS10800 69bd62c4ec9b57313fb9bd3abddd4734 270 Pfam PF00378 Enoyl-CoA hydratase/isomerase 14 268 9.2E-57 T 09-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 TK78_RS10800 69bd62c4ec9b57313fb9bd3abddd4734 270 Gene3D G3DSA:3.90.226.10 5 267 1.9E-75 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS28805 f44e45c1306bea073ea4b4bdada83daf 292 Gene3D G3DSA:1.10.3720.10 76 284 1.3E-45 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS28805 f44e45c1306bea073ea4b4bdada83daf 292 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 95 282 1.1E-22 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS28805 f44e45c1306bea073ea4b4bdada83daf 292 TIGRFAM TIGR01726 HEQRo_perm_3TM: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family 77 179 1.1E-20 T 09-03-2017 IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain GO:0005215|GO:0006810|GO:0016021 TK78_RS28805 f44e45c1306bea073ea4b4bdada83daf 292 SUPERFAMILY SSF161098 77 270 1.31E-42 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS32320 3de17716646bd2d940bc0d3624b0b08d 242 Gene3D G3DSA:1.10.10.10 174 227 2.0E-14 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32320 3de17716646bd2d940bc0d3624b0b08d 242 SMART SM01012 170 225 1.4E-19 T 09-03-2017 IPR005561 ANTAR domain GO:0003723 TK78_RS32320 3de17716646bd2d940bc0d3624b0b08d 242 SUPERFAMILY SSF52172 153 225 2.09E-6 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS32320 3de17716646bd2d940bc0d3624b0b08d 242 SMART SM00065 21 168 1.2E-6 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS32320 3de17716646bd2d940bc0d3624b0b08d 242 Pfam PF03861 ANTAR domain 172 225 4.3E-18 T 09-03-2017 IPR005561 ANTAR domain GO:0003723 TK78_RS32320 3de17716646bd2d940bc0d3624b0b08d 242 SUPERFAMILY SSF55781 21 169 1.68E-22 T 09-03-2017 IPR029016 GAF domain-like TK78_RS32320 3de17716646bd2d940bc0d3624b0b08d 242 Pfam PF13185 GAF domain 20 158 2.4E-14 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS32320 3de17716646bd2d940bc0d3624b0b08d 242 PIRSF PIRSF036625 3 236 2.2E-54 T 09-03-2017 IPR012074 GAF-ANTAR transcription anti-termination regulator, putative TK78_RS32320 3de17716646bd2d940bc0d3624b0b08d 242 Gene3D G3DSA:3.30.450.40 13 173 7.1E-23 T 09-03-2017 IPR029016 GAF domain-like TK78_RS15495 0cc1269dc5e2aee5ea5b493e1dbc410a 67 Pfam PF12728 Helix-turn-helix domain 10 56 3.3E-10 T 09-03-2017 TK78_RS15495 0cc1269dc5e2aee5ea5b493e1dbc410a 67 TIGRFAM TIGR01764 excise: DNA binding domain, excisionase family 11 56 3.4E-9 T 09-03-2017 IPR010093 SinI-like, DNA-binding domain GO:0003677 TK78_RS34400 c2d693c1be2ae0c6b9873cb1cc4e86e8 314 SUPERFAMILY SSF54637 216 304 3.73E-7 T 09-03-2017 IPR029069 HotDog domain TK78_RS34400 c2d693c1be2ae0c6b9873cb1cc4e86e8 314 Pfam PF03756 A-factor biosynthesis hotdog domain 196 306 6.8E-17 T 09-03-2017 IPR005509 A-factor biosynthesis hotdog domain TK78_RS34400 c2d693c1be2ae0c6b9873cb1cc4e86e8 314 Pfam PF03756 A-factor biosynthesis hotdog domain 28 162 5.6E-32 T 09-03-2017 IPR005509 A-factor biosynthesis hotdog domain TK78_RS34400 c2d693c1be2ae0c6b9873cb1cc4e86e8 314 Gene3D G3DSA:3.10.129.10 229 304 3.3E-5 T 09-03-2017 IPR029069 HotDog domain TK78_RS00090 5997c2727e62bd8c1978a64a3f13951f 100 Pfam PF08751 TrwC relaxase 1 98 4.8E-22 T 09-03-2017 IPR014862 TrwC relaxase TK78_RS00090 5997c2727e62bd8c1978a64a3f13951f 100 SUPERFAMILY SSF55464 1 97 1.01E-19 T 09-03-2017 TK78_RS19415 804267cd92cbe1cb66077c84d9fb870a 466 Gene3D G3DSA:1.10.390.10 331 459 1.2E-19 T 09-03-2017 TK78_RS19415 804267cd92cbe1cb66077c84d9fb870a 466 SUPERFAMILY SSF63737 37 234 5.23E-37 T 09-03-2017 TK78_RS19415 804267cd92cbe1cb66077c84d9fb870a 466 SUPERFAMILY SSF55486 243 462 4.98E-49 T 09-03-2017 TK78_RS19415 804267cd92cbe1cb66077c84d9fb870a 466 Pfam PF01433 Peptidase family M1 52 286 2.3E-20 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS19415 804267cd92cbe1cb66077c84d9fb870a 466 Pfam PF01433 Peptidase family M1 317 356 1.1E-16 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS19415 804267cd92cbe1cb66077c84d9fb870a 466 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 218 233 1.2E-12 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS19415 804267cd92cbe1cb66077c84d9fb870a 466 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 317 332 1.2E-12 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS19415 804267cd92cbe1cb66077c84d9fb870a 466 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 336 348 1.2E-12 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS19415 804267cd92cbe1cb66077c84d9fb870a 466 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 171 186 1.2E-12 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS06705 5427b642e40baa94f230198945e51b97 392 Pfam PF09587 Bacterial capsule synthesis protein PGA_cap 35 283 1.4E-64 T 09-03-2017 IPR019079 Capsule synthesis protein, CapA TK78_RS06705 5427b642e40baa94f230198945e51b97 392 SUPERFAMILY SSF56300 35 306 9.36E-37 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS06705 5427b642e40baa94f230198945e51b97 392 Gene3D G3DSA:3.60.21.10 99 287 1.0E-20 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS06705 5427b642e40baa94f230198945e51b97 392 SMART SM00854 35 285 1.2E-75 T 09-03-2017 IPR019079 Capsule synthesis protein, CapA TK78_RS22940 8bfc265c10291c36d3ce4f06b688c960 643 Pfam PF03703 Bacterial PH domain 463 520 2.5E-8 T 09-03-2017 IPR005182 Domain of unknown function DUF304 TK78_RS22940 8bfc265c10291c36d3ce4f06b688c960 643 Pfam PF03703 Bacterial PH domain 87 165 2.9E-10 T 09-03-2017 IPR005182 Domain of unknown function DUF304 TK78_RS06970 14f99fc41204fa611e250a7ed223aa03 143 SMART SM00357 4 67 3.4E-9 T 09-03-2017 IPR011129 Cold shock protein GO:0003676 TK78_RS06970 14f99fc41204fa611e250a7ed223aa03 143 Pfam PF00313 'Cold-shock' DNA-binding domain 3 65 2.5E-13 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS06970 14f99fc41204fa611e250a7ed223aa03 143 Gene3D G3DSA:2.40.50.140 3 70 7.1E-18 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS06970 14f99fc41204fa611e250a7ed223aa03 143 SUPERFAMILY SSF50249 2 66 1.03E-14 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS06970 14f99fc41204fa611e250a7ed223aa03 143 PRINTS PR00050 Cold shock protein signature 40 58 1.7E-5 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS06970 14f99fc41204fa611e250a7ed223aa03 143 PRINTS PR00050 Cold shock protein signature 5 20 1.7E-5 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS06970 14f99fc41204fa611e250a7ed223aa03 143 PRINTS PR00050 Cold shock protein signature 26 35 1.7E-5 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS22060 3debc1f34bfa9a9612972ee4f62eee95 342 Pfam PF07726 ATPase family associated with various cellular activities (AAA) 64 194 1.2E-63 T 09-03-2017 IPR011703 ATPase, AAA-3 GO:0005524|GO:0016887 TK78_RS22060 3debc1f34bfa9a9612972ee4f62eee95 342 PIRSF PIRSF002849 5 342 1.5E-132 T 09-03-2017 IPR016366 ATPase chaperone, AAA-type, MoxR, predicted TK78_RS22060 3debc1f34bfa9a9612972ee4f62eee95 342 SUPERFAMILY SSF52540 28 318 8.91E-48 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22060 3debc1f34bfa9a9612972ee4f62eee95 342 SMART SM00382 61 202 0.0014 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS22060 3debc1f34bfa9a9612972ee4f62eee95 342 Gene3D G3DSA:1.10.8.300 232 338 1.3E-39 T 09-03-2017 TK78_RS22060 3debc1f34bfa9a9612972ee4f62eee95 342 Gene3D G3DSA:3.40.50.300 46 210 7.3E-43 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22000 7693d83027dbe60bdcdb16249cc46db1 60 SUPERFAMILY SSF158997 1 58 6.28E-16 T 09-03-2017 TK78_RS22000 7693d83027dbe60bdcdb16249cc46db1 60 Gene3D G3DSA:2.20.25.10 10 58 5.2E-21 T 09-03-2017 TK78_RS22000 7693d83027dbe60bdcdb16249cc46db1 60 Pfam PF03966 Trm112p-like protein 7 47 2.9E-7 T 09-03-2017 IPR005651 Uncharacterised protein family UPF0434/Trm112 TK78_RS28995 42f2088f8598530ac43d4759ff362243 446 Pfam PF07690 Major Facilitator Superfamily 18 243 8.8E-20 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS28995 42f2088f8598530ac43d4759ff362243 446 Gene3D G3DSA:1.20.1250.20 17 203 5.6E-16 T 09-03-2017 TK78_RS28995 42f2088f8598530ac43d4759ff362243 446 Gene3D G3DSA:1.20.1250.20 212 387 1.1E-20 T 09-03-2017 TK78_RS28995 42f2088f8598530ac43d4759ff362243 446 SUPERFAMILY SSF103473 12 390 1.57E-44 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS23420 ab469e03418f46d95e38606377784af1 485 SUPERFAMILY SSF103473 242 453 8.37E-56 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS23420 ab469e03418f46d95e38606377784af1 485 SUPERFAMILY SSF103473 4 191 8.37E-56 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS23420 ab469e03418f46d95e38606377784af1 485 Pfam PF07690 Major Facilitator Superfamily 13 403 9.4E-47 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS23420 ab469e03418f46d95e38606377784af1 485 Gene3D G3DSA:1.20.1250.20 257 457 1.7E-15 T 09-03-2017 TK78_RS23420 ab469e03418f46d95e38606377784af1 485 Gene3D G3DSA:1.20.1250.20 8 188 1.7E-25 T 09-03-2017 TK78_RS05050 6befc4fabb4777182d74f88201c28ddf 297 PIRSF PIRSF000103 2 297 1.5E-82 T 09-03-2017 IPR015815 3-hydroxyisobutyrate dehydrogenase-related GO:0016491|GO:0055114 Reactome: R-HSA-70895 TK78_RS05050 6befc4fabb4777182d74f88201c28ddf 297 Pfam PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase 7 166 2.8E-51 T 09-03-2017 IPR006115 6-phosphogluconate dehydrogenase, NADP-binding GO:0004616|GO:0055114 TK78_RS05050 6befc4fabb4777182d74f88201c28ddf 297 Gene3D G3DSA:1.10.1040.10 169 294 6.5E-41 T 09-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 TK78_RS05050 6befc4fabb4777182d74f88201c28ddf 297 SUPERFAMILY SSF48179 167 294 3.85E-37 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS05050 6befc4fabb4777182d74f88201c28ddf 297 Pfam PF14833 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 169 287 1.7E-39 T 09-03-2017 IPR029154 3-hydroxyisobutyrate dehydrogenase, NAD-binding domain GO:0051287 TK78_RS05050 6befc4fabb4777182d74f88201c28ddf 297 Gene3D G3DSA:3.40.50.720 6 167 2.1E-58 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS05050 6befc4fabb4777182d74f88201c28ddf 297 TIGRFAM TIGR01505 tartro_sem_red: 2-hydroxy-3-oxopropionate reductase 7 297 5.0E-148 T 09-03-2017 IPR006398 2-hydroxy-3-oxopropionate reductase GO:0008679|GO:0046487|GO:0055114 KEGG: 00630+1.1.1.60 TK78_RS05050 6befc4fabb4777182d74f88201c28ddf 297 SUPERFAMILY SSF51735 6 166 9.78E-49 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS21085 8cf389325c659b642d747e30868d245d 187 SUPERFAMILY SSF55729 4 177 2.71E-50 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS21085 8cf389325c659b642d747e30868d245d 187 Pfam PF13302 Acetyltransferase (GNAT) domain 12 152 3.2E-32 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS21085 8cf389325c659b642d747e30868d245d 187 Gene3D G3DSA:3.40.630.30 4 182 1.7E-55 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS26440 26f85372604173d978a51cc9ec090eea 164 Gene3D G3DSA:1.10.10.10 17 149 9.7E-28 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS26440 26f85372604173d978a51cc9ec090eea 164 Pfam PF12802 MarR family 53 102 8.8E-13 T 09-03-2017 TK78_RS26440 26f85372604173d978a51cc9ec090eea 164 SUPERFAMILY SSF46785 17 149 8.79E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS26440 26f85372604173d978a51cc9ec090eea 164 ProSitePatterns PS01117 MarR-type HTH domain signature. 76 111 - T 09-03-2017 IPR023187 Transcriptional regulator MarR-type, conserved site TK78_RS26440 26f85372604173d978a51cc9ec090eea 164 SMART SM00347 36 138 8.9E-11 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS26440 26f85372604173d978a51cc9ec090eea 164 PRINTS PR00598 Bacterial regulatory protein MarR family signature 79 94 6.4E-6 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS26440 26f85372604173d978a51cc9ec090eea 164 PRINTS PR00598 Bacterial regulatory protein MarR family signature 62 78 6.4E-6 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS26440 26f85372604173d978a51cc9ec090eea 164 PRINTS PR00598 Bacterial regulatory protein MarR family signature 98 114 6.4E-6 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS09370 579ff836f2659b112bd80ccf9a4f7f23 456 Pfam PF00375 Sodium:dicarboxylate symporter family 14 404 1.9E-100 T 09-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 TK78_RS09370 579ff836f2659b112bd80ccf9a4f7f23 456 PRINTS PR00173 Glutamate-aspartate symporter signature 79 104 2.2E-25 T 09-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 TK78_RS09370 579ff836f2659b112bd80ccf9a4f7f23 456 PRINTS PR00173 Glutamate-aspartate symporter signature 194 213 2.2E-25 T 09-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 TK78_RS09370 579ff836f2659b112bd80ccf9a4f7f23 456 PRINTS PR00173 Glutamate-aspartate symporter signature 295 321 2.2E-25 T 09-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 TK78_RS09370 579ff836f2659b112bd80ccf9a4f7f23 456 PRINTS PR00173 Glutamate-aspartate symporter signature 330 349 2.2E-25 T 09-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 TK78_RS09370 579ff836f2659b112bd80ccf9a4f7f23 456 PRINTS PR00173 Glutamate-aspartate symporter signature 12 32 2.2E-25 T 09-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 TK78_RS09370 579ff836f2659b112bd80ccf9a4f7f23 456 SUPERFAMILY SSF118215 14 404 1.2E-102 T 09-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 TK78_RS09370 579ff836f2659b112bd80ccf9a4f7f23 456 Gene3D G3DSA:1.10.3860.10 7 410 2.6E-105 T 09-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 TK78_RS22925 59e97bc7ce75794cb7344d38f16a1e46 161 Hamap MF_00761 UPF0303 protein . 3 158 34.696 T 09-03-2017 IPR010371 Uncharacterised protein family UPF0303 TK78_RS22925 59e97bc7ce75794cb7344d38f16a1e46 161 Pfam PF03928 Haem-degrading 25 153 1.6E-33 T 09-03-2017 IPR005624 Haem-degrading TK78_RS22925 59e97bc7ce75794cb7344d38f16a1e46 161 PIRSF PIRSF008757 1 160 1.1E-64 T 09-03-2017 IPR010371 Uncharacterised protein family UPF0303 TK78_RS22925 59e97bc7ce75794cb7344d38f16a1e46 161 SUPERFAMILY SSF143744 16 155 4.58E-27 T 09-03-2017 TK78_RS27075 3cee4a9920442f843a9eae66f082c7ce 571 Hamap MF_00208 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [murE]. 64 550 32.482 T 09-03-2017 IPR005761 UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase GO:0005524|GO:0005737|GO:0008360|GO:0016881|GO:0051301 TK78_RS27075 3cee4a9920442f843a9eae66f082c7ce 571 SUPERFAMILY SSF53623 165 392 3.27E-67 T 09-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 TK78_RS27075 3cee4a9920442f843a9eae66f082c7ce 571 SUPERFAMILY SSF53244 393 552 2.35E-42 T 09-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TK78_RS27075 3cee4a9920442f843a9eae66f082c7ce 571 TIGRFAM TIGR01085 murE: UDP-N-acetylmuramyl-tripeptide synthetase 82 550 7.3E-143 T 09-03-2017 IPR005761 UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase GO:0005524|GO:0005737|GO:0008360|GO:0016881|GO:0051301 TK78_RS27075 3cee4a9920442f843a9eae66f082c7ce 571 Pfam PF08245 Mur ligase middle domain 171 372 1.5E-49 T 09-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 TK78_RS27075 3cee4a9920442f843a9eae66f082c7ce 571 Gene3D G3DSA:3.90.190.20 397 543 2.0E-48 T 09-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TK78_RS27075 3cee4a9920442f843a9eae66f082c7ce 571 Gene3D G3DSA:3.40.1190.10 168 396 4.8E-78 T 09-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 TK78_RS27075 3cee4a9920442f843a9eae66f082c7ce 571 Gene3D G3DSA:3.40.1390.10 79 160 2.4E-20 T 09-03-2017 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 TK78_RS27075 3cee4a9920442f843a9eae66f082c7ce 571 SUPERFAMILY SSF63418 72 160 9.68E-20 T 09-03-2017 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 TK78_RS27075 3cee4a9920442f843a9eae66f082c7ce 571 Pfam PF02875 Mur ligase family, glutamate ligase domain 393 477 4.8E-19 T 09-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TK78_RS27075 3cee4a9920442f843a9eae66f082c7ce 571 Pfam PF01225 Mur ligase family, catalytic domain 83 158 3.6E-12 T 09-03-2017 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 TK78_RS10820 f106d8a7f7be7874b40ecc76c79f0cf9 261 TIGRFAM TIGR00730 TIGR00730: TIGR00730 family protein 83 255 2.9E-41 T 09-03-2017 IPR005269 Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG TK78_RS10820 f106d8a7f7be7874b40ecc76c79f0cf9 261 Gene3D G3DSA:3.40.50.450 62 257 8.1E-63 T 09-03-2017 TK78_RS10820 f106d8a7f7be7874b40ecc76c79f0cf9 261 SUPERFAMILY SSF102405 53 252 2.44E-60 T 09-03-2017 TK78_RS10820 f106d8a7f7be7874b40ecc76c79f0cf9 261 Pfam PF03641 Possible lysine decarboxylase 125 252 1.7E-33 T 09-03-2017 IPR031100 LOG family TK78_RS13930 b04c7e435036144cfcf668035d4152b7 294 Gene3D G3DSA:3.90.226.10 35 234 3.7E-65 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS13930 b04c7e435036144cfcf668035d4152b7 294 Pfam PF00378 Enoyl-CoA hydratase/isomerase 42 293 2.5E-58 T 09-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 TK78_RS13930 b04c7e435036144cfcf668035d4152b7 294 Gene3D G3DSA:1.10.12.10 236 294 1.7E-18 T 09-03-2017 IPR014748 Crontonase, C-terminal TK78_RS13930 b04c7e435036144cfcf668035d4152b7 294 SUPERFAMILY SSF52096 34 294 1.04E-82 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS10110 f888c6a0b8d3a1f0908008ba8f430240 339 Pfam PF03435 Saccharopine dehydrogenase NADP binding domain 1 111 1.0E-10 T 09-03-2017 IPR005097 Saccharopine dehydrogenase, NADP binding domain GO:0016491|GO:0055114 TK78_RS10110 f888c6a0b8d3a1f0908008ba8f430240 339 SUPERFAMILY SSF51735 1 147 6.24E-14 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS10110 f888c6a0b8d3a1f0908008ba8f430240 339 Gene3D G3DSA:3.40.50.720 1 139 3.1E-15 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS16545 e378d128066bcc5be77c60e77b7491c6 367 SUPERFAMILY SSF53335 12 203 1.16E-26 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS16545 e378d128066bcc5be77c60e77b7491c6 367 Gene3D G3DSA:3.40.50.150 18 243 3.1E-48 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS16545 e378d128066bcc5be77c60e77b7491c6 367 Pfam PF01135 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) 12 240 2.4E-25 T 09-03-2017 TK78_RS25255 a3c2580cf840353c9f81ff5f1c745b90 642 SMART SM00382 422 609 3.6E-15 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS25255 a3c2580cf840353c9f81ff5f1c745b90 642 Pfam PF00005 ABC transporter 414 563 4.8E-31 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS25255 a3c2580cf840353c9f81ff5f1c745b90 642 ProSitePatterns PS00211 ABC transporters family signature. 535 549 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS25255 a3c2580cf840353c9f81ff5f1c745b90 642 SUPERFAMILY SSF52540 391 634 2.11E-89 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS25255 a3c2580cf840353c9f81ff5f1c745b90 642 Gene3D G3DSA:1.20.1560.10 26 383 4.2E-86 T 09-03-2017 TK78_RS25255 a3c2580cf840353c9f81ff5f1c745b90 642 Gene3D G3DSA:3.40.50.300 397 627 2.5E-79 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS25255 a3c2580cf840353c9f81ff5f1c745b90 642 SUPERFAMILY SSF90123 26 70 3.66E-84 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS25255 a3c2580cf840353c9f81ff5f1c745b90 642 SUPERFAMILY SSF90123 111 384 3.66E-84 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS25255 a3c2580cf840353c9f81ff5f1c745b90 642 Pfam PF00664 ABC transporter transmembrane region 43 351 8.5E-57 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS00135 a47ce753faaff3ec11a494f69aee5e32 159 SUPERFAMILY SSF51604 2 141 1.09E-37 T 09-03-2017 IPR029065 Enolase C-terminal domain-like TK78_RS00135 a47ce753faaff3ec11a494f69aee5e32 159 Pfam PF13378 Enolase C-terminal domain-like 1 147 1.0E-34 T 09-03-2017 IPR029065 Enolase C-terminal domain-like TK78_RS00135 a47ce753faaff3ec11a494f69aee5e32 159 Gene3D G3DSA:3.20.20.120 2 141 2.0E-39 T 09-03-2017 IPR029065 Enolase C-terminal domain-like TK78_RS32660 cbeeb16c0ee43df77d8bf5a674aa0614 311 Gene3D G3DSA:3.30.2010.10 118 196 8.3E-8 T 09-03-2017 TK78_RS32660 cbeeb16c0ee43df77d8bf5a674aa0614 311 Pfam PF01435 Peptidase family M48 137 211 1.8E-8 T 09-03-2017 IPR001915 Peptidase M48 GO:0004222|GO:0006508 TK78_RS15560 fe7990dfbab5c77232fbf9385afc6c54 155 SUPERFAMILY SSF143120 7 54 3.92E-5 T 09-03-2017 TK78_RS09575 2b7176a402e033ad8680ae8a9315eb89 385 Pfam PF00005 ABC transporter 18 156 3.5E-25 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS09575 2b7176a402e033ad8680ae8a9315eb89 385 SUPERFAMILY SSF52540 2 218 5.92E-55 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09575 2b7176a402e033ad8680ae8a9315eb89 385 Gene3D G3DSA:3.40.50.300 1 223 7.2E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09575 2b7176a402e033ad8680ae8a9315eb89 385 SMART SM00382 26 204 5.1E-10 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS06895 8f05bed77d82de4e1a7e191b2b620f97 176 Pfam PF00692 dUTPase 17 147 2.1E-29 T 09-03-2017 IPR008180 Deoxyuridine triphosphate nucleotidohydrolase/Deoxycytidine triphosphate deaminase GO:0016787|GO:0046080 TK78_RS06895 8f05bed77d82de4e1a7e191b2b620f97 176 Hamap MF_00116 Deoxyuridine 5'-triphosphate nucleotidohydrolase [dut]. 6 148 30.506 T 09-03-2017 IPR008181 Deoxyuridine triphosphate nucleotidohydrolase GO:0004170|GO:0046080 KEGG: 00240+3.6.1.23|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7206|Reactome: R-HSA-500753 TK78_RS06895 8f05bed77d82de4e1a7e191b2b620f97 176 SUPERFAMILY SSF51283 4 147 2.36E-42 T 09-03-2017 IPR029054 dUTPase-like TK78_RS06895 8f05bed77d82de4e1a7e191b2b620f97 176 Gene3D G3DSA:2.70.40.10 6 147 1.9E-50 T 09-03-2017 IPR029054 dUTPase-like TK78_RS06895 8f05bed77d82de4e1a7e191b2b620f97 176 TIGRFAM TIGR00576 dut: dUTP diphosphatase 9 147 6.8E-49 T 09-03-2017 IPR008181 Deoxyuridine triphosphate nucleotidohydrolase GO:0004170|GO:0046080 KEGG: 00240+3.6.1.23|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7206|Reactome: R-HSA-500753 TK78_RS26725 d6e3e508289480f954e4f0345e0fa1db 392 Pfam PF02445 Quinolinate synthetase A protein 50 390 5.6E-107 T 09-03-2017 IPR003473 Quinolinate synthetase A GO:0008987|GO:0009435|GO:0051539 MetaCyc: PWY-5316|MetaCyc: PWY-7342 TK78_RS26725 d6e3e508289480f954e4f0345e0fa1db 392 Hamap MF_00569 Quinolinate synthase A [nadA]. 41 391 57.569 T 09-03-2017 IPR023515 Quinolinate synthase A, type 3 GO:0016765 MetaCyc: PWY-5316|MetaCyc: PWY-7342 TK78_RS26725 d6e3e508289480f954e4f0345e0fa1db 392 SUPERFAMILY SSF142754 50 391 2.22E-94 T 09-03-2017 TK78_RS26725 d6e3e508289480f954e4f0345e0fa1db 392 TIGRFAM TIGR00550 nadA: quinolinate synthetase complex, A subunit 44 391 1.4E-98 T 09-03-2017 IPR003473 Quinolinate synthetase A GO:0008987|GO:0009435|GO:0051539 MetaCyc: PWY-5316|MetaCyc: PWY-7342 TK78_RS33385 3382dbe12030c167913d0c5574247f5d 308 Gene3D G3DSA:1.10.260.40 1 66 4.6E-9 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS33385 3382dbe12030c167913d0c5574247f5d 308 SUPERFAMILY SSF48498 183 275 2.45E-20 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS33385 3382dbe12030c167913d0c5574247f5d 308 Gene3D G3DSA:1.10.357.10 98 280 3.9E-39 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS33385 3382dbe12030c167913d0c5574247f5d 308 SUPERFAMILY SSF47413 9 66 4.22E-8 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS33385 3382dbe12030c167913d0c5574247f5d 308 Pfam PF13977 Bacterial transcriptional repressor 183 302 1.0E-26 T 09-03-2017 TK78_RS33385 3382dbe12030c167913d0c5574247f5d 308 SUPERFAMILY SSF46689 105 178 1.69E-13 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS33385 3382dbe12030c167913d0c5574247f5d 308 SMART SM00530 9 64 5.0E-5 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS33385 3382dbe12030c167913d0c5574247f5d 308 Pfam PF00440 Bacterial regulatory proteins, tetR family 113 159 8.5E-14 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS17160 44b0e5ae4c592ca4f533afca97081880 313 Gene3D G3DSA:3.40.630.30 14 134 2.2E-12 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS17160 44b0e5ae4c592ca4f533afca97081880 313 Gene3D G3DSA:3.40.630.30 171 234 9.5E-5 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS17160 44b0e5ae4c592ca4f533afca97081880 313 SUPERFAMILY SSF55729 12 290 1.64E-28 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS17160 44b0e5ae4c592ca4f533afca97081880 313 Pfam PF13673 Acetyltransferase (GNAT) domain 75 134 6.0E-7 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS08490 6666ff05cf240950b4690ef4f062f798 229 Gene3D G3DSA:1.10.101.10 47 75 2.5E-5 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS08490 6666ff05cf240950b4690ef4f062f798 229 Pfam PF01471 Putative peptidoglycan binding domain 50 70 5.5E-5 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS08490 6666ff05cf240950b4690ef4f062f798 229 SUPERFAMILY SSF47090 47 75 3.14E-5 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS24345 fa828945ac211dd4ec70959ff18f40be 431 Gene3D G3DSA:3.30.465.10 76 184 1.4E-12 T 09-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 TK78_RS24345 fa828945ac211dd4ec70959ff18f40be 431 Gene3D G3DSA:3.30.43.10 19 67 7.3E-7 T 09-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 TK78_RS24345 fa828945ac211dd4ec70959ff18f40be 431 SUPERFAMILY SSF56176 14 184 7.94E-39 T 09-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 TK78_RS24345 fa828945ac211dd4ec70959ff18f40be 431 Pfam PF01565 FAD binding domain 22 154 1.7E-24 T 09-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 TK78_RS24345 fa828945ac211dd4ec70959ff18f40be 431 ProSitePatterns PS00862 Oxygen oxidoreductases covalent FAD-binding site. 22 55 - T 09-03-2017 IPR006093 Oxygen oxidoreductase covalent FAD-binding site GO:0016491|GO:0055114 TK78_RS28900 a0a5acd375175be1ee5366fe1f56f492 348 TIGRFAM TIGR01167 LPXTG_anchor: LPXTG cell wall anchor domain 304 338 1.4E-4 T 09-03-2017 IPR019931 LPXTG cell wall anchor domain TK78_RS28900 a0a5acd375175be1ee5366fe1f56f492 348 Gene3D G3DSA:2.70.50.50 31 210 4.6E-51 T 09-03-2017 TK78_RS28900 a0a5acd375175be1ee5366fe1f56f492 348 Pfam PF03067 Lytic polysaccharide mono-oxygenase, cellulose-degrading 31 207 8.6E-40 T 09-03-2017 IPR004302 Chitin-binding protein, N-terminal TK78_RS28900 a0a5acd375175be1ee5366fe1f56f492 348 SUPERFAMILY SSF81296 31 211 2.8E-48 T 09-03-2017 IPR014756 Immunoglobulin E-set TK78_RS10050 921991a9186b2152855f41bd598a865a 322 Gene3D G3DSA:3.90.180.10 11 158 1.7E-27 T 09-03-2017 IPR011032 GroES-like TK78_RS10050 921991a9186b2152855f41bd598a865a 322 Gene3D G3DSA:3.40.50.720 159 267 1.7E-20 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS10050 921991a9186b2152855f41bd598a865a 322 SUPERFAMILY SSF51735 126 287 8.97E-37 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS10050 921991a9186b2152855f41bd598a865a 322 Pfam PF00107 Zinc-binding dehydrogenase 165 283 6.8E-18 T 09-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 TK78_RS10050 921991a9186b2152855f41bd598a865a 322 SMART SM00829 13 318 2.7E-12 T 09-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 TK78_RS10050 921991a9186b2152855f41bd598a865a 322 SUPERFAMILY SSF50129 6 154 1.63E-29 T 09-03-2017 IPR011032 GroES-like TK78_RS12260 86466343d477ca40f342242a9bf4449d 227 PIRSF PIRSF006324 1 227 4.4E-50 T 09-03-2017 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 TK78_RS12260 86466343d477ca40f342242a9bf4449d 227 Pfam PF01810 LysE type translocator 17 225 1.0E-45 T 09-03-2017 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 TK78_RS27430 94a562d6a712384d6c370d83cdfe200b 190 Pfam PF05962 HutD 9 184 8.4E-52 T 09-03-2017 IPR010282 Uncharacterised protein family HutD/Ves TK78_RS27430 94a562d6a712384d6c370d83cdfe200b 190 SUPERFAMILY SSF51182 3 186 9.78E-53 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS27430 94a562d6a712384d6c370d83cdfe200b 190 Gene3D G3DSA:2.60.120.10 9 117 3.0E-35 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS03935 d0dd287268dcef8680d4e357ded1b7a8 334 SUPERFAMILY SSF51658 9 316 5.24E-57 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS03935 d0dd287268dcef8680d4e357ded1b7a8 334 Pfam PF07582 AP endonuclease family 2 C terminus 275 329 1.0E-22 T 09-03-2017 IPR011418 AP endonuclease, family 2, C-terminal TK78_RS03935 d0dd287268dcef8680d4e357ded1b7a8 334 Gene3D G3DSA:3.20.20.150 2 316 2.1E-76 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS03935 d0dd287268dcef8680d4e357ded1b7a8 334 Pfam PF01261 Xylose isomerase-like TIM barrel 22 272 1.7E-37 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS17455 3f57cc6a07e3e3f4a308dcb5f0823624 194 Gene3D G3DSA:2.60.60.30 15 188 4.1E-32 T 09-03-2017 TK78_RS17455 3f57cc6a07e3e3f4a308dcb5f0823624 194 Pfam PF02342 TerD domain 15 175 4.3E-18 T 09-03-2017 IPR003325 TerD domain GO:0006950 TK78_RS00655 d09e884fb554344caa391b092f9ab125 462 Pfam PF05762 VWA domain containing CoxE-like protein 238 445 1.0E-27 T 09-03-2017 IPR008912 Uncharacterised protein family CoxE-like TK78_RS00655 d09e884fb554344caa391b092f9ab125 462 SUPERFAMILY SSF53300 297 436 5.93E-11 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS24470 f37e0e7b583041f1d393957cc9caa66e 508 Pfam PF05235 CHAD domain 224 456 3.2E-49 T 09-03-2017 IPR007899 CHAD domain TK78_RS24470 f37e0e7b583041f1d393957cc9caa66e 508 SMART SM01118 5 203 2.8E-15 T 09-03-2017 IPR023577 CYTH domain Reactome: R-HSA-196819 TK78_RS24470 f37e0e7b583041f1d393957cc9caa66e 508 Pfam PF01928 CYTH domain 6 195 1.1E-15 T 09-03-2017 IPR023577 CYTH domain Reactome: R-HSA-196819 TK78_RS24470 f37e0e7b583041f1d393957cc9caa66e 508 SUPERFAMILY SSF55154 6 200 5.89E-41 T 09-03-2017 IPR033469 CYTH-like domain Reactome: R-HSA-196819 TK78_RS24470 f37e0e7b583041f1d393957cc9caa66e 508 Gene3D G3DSA:2.40.320.10 6 204 7.3E-51 T 09-03-2017 IPR023577 CYTH domain Reactome: R-HSA-196819 TK78_RS24470 f37e0e7b583041f1d393957cc9caa66e 508 SMART SM00880 224 488 1.9E-64 T 09-03-2017 IPR007899 CHAD domain TK78_RS22740 8b5d1cb69d12dfa7bd88154faa5e036e 415 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 210 394 7.4E-23 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS22740 8b5d1cb69d12dfa7bd88154faa5e036e 415 ProSitePatterns PS01098 Lipolytic enzymes "G-D-S-L" family, serine active site. 208 218 - T 09-03-2017 IPR008265 Lipase, GDSL, active site GO:0006629|GO:0016298 Reactome: R-HSA-1482788|Reactome: R-HSA-975634 TK78_RS22740 8b5d1cb69d12dfa7bd88154faa5e036e 415 Gene3D G3DSA:3.40.50.1110 208 399 3.8E-32 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS22740 8b5d1cb69d12dfa7bd88154faa5e036e 415 SUPERFAMILY SSF52266 208 399 3.82E-43 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS10075 e682f852cd7e209d8254f3eec5635908 253 Gene3D G3DSA:3.40.50.150 9 250 1.3E-29 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS10075 e682f852cd7e209d8254f3eec5635908 253 SUPERFAMILY SSF53335 4 190 3.8E-31 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS10075 e682f852cd7e209d8254f3eec5635908 253 Pfam PF13649 Methyltransferase domain 49 148 2.4E-15 T 09-03-2017 TK78_RS02600 118e75babb04186c9534c8983cb6be02 281 Gene3D G3DSA:1.10.3720.10 9 268 3.4E-58 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS02600 118e75babb04186c9534c8983cb6be02 281 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 114 274 3.4E-15 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS02600 118e75babb04186c9534c8983cb6be02 281 SUPERFAMILY SSF161098 12 281 1.96E-66 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS19265 4e540e7c1f848840c208b696ee77e59e 407 SUPERFAMILY SSF52777 12 160 1.78E-24 T 09-03-2017 TK78_RS19265 4e540e7c1f848840c208b696ee77e59e 407 Pfam PF00668 Condensation domain 17 277 8.4E-25 T 09-03-2017 IPR001242 Condensation domain TK78_RS19265 4e540e7c1f848840c208b696ee77e59e 407 SUPERFAMILY SSF52777 169 400 2.45E-21 T 09-03-2017 TK78_RS12565 45c51299e7609c851880650ab0d7576b 137 Pfam PF02310 B12 binding domain 7 120 8.0E-24 T 09-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 TK78_RS12565 45c51299e7609c851880650ab0d7576b 137 SUPERFAMILY SSF52242 5 132 4.71E-49 T 09-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 TK78_RS12565 45c51299e7609c851880650ab0d7576b 137 Gene3D G3DSA:3.40.50.280 6 133 6.2E-55 T 09-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 TK78_RS12565 45c51299e7609c851880650ab0d7576b 137 TIGRFAM TIGR00640 acid_CoA_mut_C: methylmalonyl-CoA mutase C-terminal domain 7 134 2.9E-49 T 09-03-2017 IPR006159 Methylmalonyl-CoA mutase, C-terminal GO:0016853 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 TK78_RS09215 c57409e0486aa25b43e4c3a5294acb60 505 SUPERFAMILY SSF53474 17 501 2.34E-112 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS09215 c57409e0486aa25b43e4c3a5294acb60 505 ProSitePatterns PS00122 Carboxylesterases type-B serine active site. 189 204 - T 09-03-2017 IPR019826 Carboxylesterase type B, active site TK78_RS09215 c57409e0486aa25b43e4c3a5294acb60 505 Pfam PF00135 Carboxylesterase family 17 463 1.2E-93 T 09-03-2017 IPR002018 Carboxylesterase, type B TK78_RS09215 c57409e0486aa25b43e4c3a5294acb60 505 Gene3D G3DSA:3.40.50.1820 15 501 1.6E-125 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS02110 4f9773192dd913fe7107fc1aa7c8788d 132 Gene3D G3DSA:3.40.30.10 3 102 1.0E-32 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS02110 4f9773192dd913fe7107fc1aa7c8788d 132 Pfam PF00085 Thioredoxin 3 100 3.0E-28 T 09-03-2017 IPR013766 Thioredoxin domain GO:0045454 TK78_RS02110 4f9773192dd913fe7107fc1aa7c8788d 132 SUPERFAMILY SSF52833 3 102 5.35E-33 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS02110 4f9773192dd913fe7107fc1aa7c8788d 132 ProSitePatterns PS00194 Thioredoxin family active site. 22 40 - T 09-03-2017 IPR017937 Thioredoxin, conserved site GO:0045454 TK78_RS02110 4f9773192dd913fe7107fc1aa7c8788d 132 TIGRFAM TIGR01068 thioredoxin: thioredoxin 7 102 2.3E-30 T 09-03-2017 IPR005746 Thioredoxin GO:0006662|GO:0015035|GO:0045454 TK78_RS02110 4f9773192dd913fe7107fc1aa7c8788d 132 PRINTS PR00421 Thioredoxin family signature 21 29 1.2E-7 T 09-03-2017 TK78_RS02110 4f9773192dd913fe7107fc1aa7c8788d 132 PRINTS PR00421 Thioredoxin family signature 68 79 1.2E-7 T 09-03-2017 TK78_RS02110 4f9773192dd913fe7107fc1aa7c8788d 132 PRINTS PR00421 Thioredoxin family signature 29 38 1.2E-7 T 09-03-2017 TK78_RS07980 1ee264f5dff18135a80a56fd5fa5bd5c 265 SUPERFAMILY SSF53335 18 255 2.17E-43 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS07980 1ee264f5dff18135a80a56fd5fa5bd5c 265 PIRSF PIRSF017393 1 265 1.2E-95 T 09-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type TK78_RS07980 1ee264f5dff18135a80a56fd5fa5bd5c 265 Gene3D G3DSA:3.40.50.150 4 265 4.2E-104 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS07980 1ee264f5dff18135a80a56fd5fa5bd5c 265 Pfam PF04672 S-adenosyl methyltransferase 6 264 1.7E-97 T 09-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type TK78_RS02475 9b678f619b0097f6fe5a82bc18e50b92 373 Pfam PF09362 Domain of unknown function (DUF1996) 115 329 1.3E-50 T 09-03-2017 IPR018535 Domain of unknown function DUF1996 TK78_RS01290 26320a7f81934cefc70bd892ea2d6d04 356 SUPERFAMILY SSF81345 33 350 1.09E-76 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS01290 26320a7f81934cefc70bd892ea2d6d04 356 Gene3D G3DSA:1.10.3470.10 34 353 3.9E-96 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS01290 26320a7f81934cefc70bd892ea2d6d04 356 Pfam PF01032 FecCD transport family 40 350 1.6E-88 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS16345 791e50855db2b2b85af5d51d7f1398fc 267 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 16 118 2.7E-6 T 09-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain TK78_RS16345 791e50855db2b2b85af5d51d7f1398fc 267 Gene3D G3DSA:3.10.180.10 140 252 1.2E-27 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS16345 791e50855db2b2b85af5d51d7f1398fc 267 Gene3D G3DSA:3.10.180.10 8 124 3.3E-33 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS16345 791e50855db2b2b85af5d51d7f1398fc 267 SUPERFAMILY SSF54593 16 125 3.22E-18 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS16345 791e50855db2b2b85af5d51d7f1398fc 267 SUPERFAMILY SSF54593 139 251 2.69E-17 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS33455 175c99fc57c3c3aa04c9fda406698d8a 68 Gene3D G3DSA:3.90.820.10 11 67 1.4E-25 T 09-03-2017 TK78_RS33455 175c99fc57c3c3aa04c9fda406698d8a 68 Pfam PF03621 MbtH-like protein 1 52 4.5E-26 T 09-03-2017 IPR005153 MbtH-like protein TK78_RS33455 175c99fc57c3c3aa04c9fda406698d8a 68 SMART SM00923 3 53 1.4E-26 T 09-03-2017 IPR005153 MbtH-like protein TK78_RS33455 175c99fc57c3c3aa04c9fda406698d8a 68 SUPERFAMILY SSF160582 1 66 1.29E-27 T 09-03-2017 TK78_RS03285 6c954025369a48af51358552fbf35d69 461 SUPERFAMILY SSF53187 87 244 6.95E-36 T 09-03-2017 TK78_RS03285 6c954025369a48af51358552fbf35d69 461 Gene3D G3DSA:3.40.630.10 78 348 1.0E-32 T 09-03-2017 TK78_RS03285 6c954025369a48af51358552fbf35d69 461 Pfam PF00246 Zinc carboxypeptidase 88 200 9.1E-21 T 09-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 TK78_RS03285 6c954025369a48af51358552fbf35d69 461 SMART SM00631 83 295 1.1E-4 T 09-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 TK78_RS11235 f6f6f8b2317952d95311ae8bc5ddfda7 712 Pfam PF04536 Acid phosphatase of thylakoid lumen protein 60 165 1.6E-17 T 09-03-2017 IPR007621 TPM domain TK78_RS14695 1dd06121dfb60dda3fdf477ad265f5aa 362 SUPERFAMILY SSF81345 30 352 1.7E-69 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS14695 1dd06121dfb60dda3fdf477ad265f5aa 362 Gene3D G3DSA:1.10.3470.10 33 356 5.5E-87 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS14695 1dd06121dfb60dda3fdf477ad265f5aa 362 Pfam PF01032 FecCD transport family 46 352 4.6E-79 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS26565 37171fe28f162f2e40db43a485639e43 235 ProDom PD037701 MEMBRANE INTEGRAL TRANSMEMBRANE RV2219/MT2276 NARROWLY PROBABLE PRECURSOR SIGNAL MLCB22.21 1 217 3.0E-84 T 09-03-2017 TK78_RS26565 37171fe28f162f2e40db43a485639e43 235 Pfam PF13829 Domain of unknown function (DUF4191) 14 230 6.5E-82 T 09-03-2017 IPR025445 Protein of unknown function DUF4191 TK78_RS27785 7a7bef37a7c654390f2d62ff8531f706 295 Pfam PF03009 Glycerophosphoryl diester phosphodiesterase family 46 288 5.6E-41 T 09-03-2017 IPR030395 Glycerophosphodiester phosphodiesterase domain GO:0006629|GO:0008081 TK78_RS27785 7a7bef37a7c654390f2d62ff8531f706 295 Gene3D G3DSA:3.20.20.190 32 293 1.0E-74 T 09-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 TK78_RS27785 7a7bef37a7c654390f2d62ff8531f706 295 SUPERFAMILY SSF51695 40 293 9.94E-71 T 09-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 TK78_RS19400 204999788acfb779d0c027efc81e8cd3 185 Pfam PF03928 Haem-degrading 58 180 1.9E-28 T 09-03-2017 IPR005624 Haem-degrading TK78_RS19400 204999788acfb779d0c027efc81e8cd3 185 SUPERFAMILY SSF143744 51 182 5.62E-32 T 09-03-2017 TK78_RS32325 5e135f0c3d6090c20bd893ca7b01e54a 192 Pfam PF03358 NADPH-dependent FMN reductase 22 152 2.2E-16 T 09-03-2017 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 TK78_RS32325 5e135f0c3d6090c20bd893ca7b01e54a 192 Gene3D G3DSA:3.40.50.360 28 160 1.6E-12 T 09-03-2017 IPR029039 Flavoprotein-like domain TK78_RS32325 5e135f0c3d6090c20bd893ca7b01e54a 192 SUPERFAMILY SSF52218 21 164 1.61E-18 T 09-03-2017 IPR029039 Flavoprotein-like domain TK78_RS33200 919d369c85a186c9309481fa3bed2238 399 Gene3D G3DSA:3.30.230.10 234 392 1.7E-34 T 09-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TK78_RS33200 919d369c85a186c9309481fa3bed2238 399 SMART SM00433 46 399 2.3E-9 T 09-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS33200 919d369c85a186c9309481fa3bed2238 399 SUPERFAMILY SSF54211 236 391 1.19E-28 T 09-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold TK78_RS33200 919d369c85a186c9309481fa3bed2238 399 SUPERFAMILY SSF55874 20 220 5.23E-35 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS33200 919d369c85a186c9309481fa3bed2238 399 Gene3D G3DSA:3.30.565.10 20 221 3.6E-45 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS33200 919d369c85a186c9309481fa3bed2238 399 Pfam PF00204 DNA gyrase B 234 393 5.1E-33 T 09-03-2017 IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2 GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS33200 919d369c85a186c9309481fa3bed2238 399 PRINTS PR01159 DNA gyrase subunit B signature 191 206 2.1E-19 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS33200 919d369c85a186c9309481fa3bed2238 399 PRINTS PR01159 DNA gyrase subunit B signature 257 275 2.1E-19 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS33200 919d369c85a186c9309481fa3bed2238 399 PRINTS PR01159 DNA gyrase subunit B signature 375 389 2.1E-19 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS33200 919d369c85a186c9309481fa3bed2238 399 PRINTS PR01159 DNA gyrase subunit B signature 206 219 2.1E-19 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS33200 919d369c85a186c9309481fa3bed2238 399 PRINTS PR01159 DNA gyrase subunit B signature 233 255 2.1E-19 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS33200 919d369c85a186c9309481fa3bed2238 399 PRINTS PR01159 DNA gyrase subunit B signature 327 343 2.1E-19 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS33200 919d369c85a186c9309481fa3bed2238 399 PRINTS PR01159 DNA gyrase subunit B signature 17 27 2.1E-19 T 09-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TK78_RS33200 919d369c85a186c9309481fa3bed2238 399 PRINTS PR00418 DNA topoisomerase II family signature 46 61 1.9E-11 T 09-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS33200 919d369c85a186c9309481fa3bed2238 399 PRINTS PR00418 DNA topoisomerase II family signature 124 138 1.9E-11 T 09-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS33200 919d369c85a186c9309481fa3bed2238 399 PRINTS PR00418 DNA topoisomerase II family signature 283 296 1.9E-11 T 09-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS33200 919d369c85a186c9309481fa3bed2238 399 PRINTS PR00418 DNA topoisomerase II family signature 81 94 1.9E-11 T 09-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TK78_RS33200 919d369c85a186c9309481fa3bed2238 399 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 45 184 8.2E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS05155 31cc024e591c7d7733a50967e8367697 344 SUPERFAMILY SSF51430 3 317 3.54E-98 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS05155 31cc024e591c7d7733a50967e8367697 344 Gene3D G3DSA:3.20.20.100 3 315 4.4E-98 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS05155 31cc024e591c7d7733a50967e8367697 344 Pfam PF00248 Aldo/keto reductase family 16 316 3.2E-77 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS05155 31cc024e591c7d7733a50967e8367697 344 PRINTS PR00069 Aldo-keto reductase signature 107 125 7.5E-8 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS05155 31cc024e591c7d7733a50967e8367697 344 PRINTS PR00069 Aldo-keto reductase signature 138 155 7.5E-8 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS05155 31cc024e591c7d7733a50967e8367697 344 PRINTS PR00069 Aldo-keto reductase signature 42 66 7.5E-8 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS25850 80160962db8a45af598712528947cb4c 425 Gene3D G3DSA:1.20.1250.20 23 206 2.8E-15 T 09-03-2017 TK78_RS25850 80160962db8a45af598712528947cb4c 425 Pfam PF07690 Major Facilitator Superfamily 30 353 9.5E-23 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS25850 80160962db8a45af598712528947cb4c 425 SUPERFAMILY SSF103473 9 406 2.22E-27 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS05555 41421d4ffe5cedb30e97acd449b4ab6e 649 Gene3D G3DSA:1.20.1560.10 30 344 2.6E-58 T 09-03-2017 TK78_RS05555 41421d4ffe5cedb30e97acd449b4ab6e 649 Gene3D G3DSA:3.40.50.300 413 641 1.5E-50 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS05555 41421d4ffe5cedb30e97acd449b4ab6e 649 SUPERFAMILY SSF90123 30 344 1.7E-57 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS05555 41421d4ffe5cedb30e97acd449b4ab6e 649 Pfam PF00664 ABC transporter transmembrane region 47 312 2.6E-31 T 09-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 TK78_RS05555 41421d4ffe5cedb30e97acd449b4ab6e 649 Pfam PF00005 ABC transporter 427 568 7.7E-20 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS05555 41421d4ffe5cedb30e97acd449b4ab6e 649 SMART SM00382 436 614 1.8E-8 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS05555 41421d4ffe5cedb30e97acd449b4ab6e 649 SUPERFAMILY SSF52540 408 637 2.25E-57 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS02705 931585a95d895e48c2a283579a51da70 209 Gene3D G3DSA:1.10.10.60 15 69 3.6E-15 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS02705 931585a95d895e48c2a283579a51da70 209 Pfam PF00440 Bacterial regulatory proteins, tetR family 29 73 4.8E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS02705 931585a95d895e48c2a283579a51da70 209 SUPERFAMILY SSF48498 88 197 7.87E-15 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS02705 931585a95d895e48c2a283579a51da70 209 SUPERFAMILY SSF46689 16 78 3.54E-12 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS02705 931585a95d895e48c2a283579a51da70 209 Pfam PF16859 Bacterial transcriptional repressor C-terminal 85 194 6.3E-25 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS02705 931585a95d895e48c2a283579a51da70 209 Gene3D G3DSA:1.10.357.10 70 197 2.8E-23 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS22545 e03cf08b10c9f67e4cf800b82af45552 160 Pfam PF04686 Streptomyces sporulation and cell division protein, SsgA 23 120 3.4E-35 T 09-03-2017 IPR006776 Sporulation-specific cell division protein SsgB GO:0051301 TK78_RS23750 bbfeaea412b80008ae986e8723b0ad0d 395 Gene3D G3DSA:3.20.20.70 132 327 2.6E-17 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS23750 bbfeaea412b80008ae986e8723b0ad0d 395 Gene3D G3DSA:3.20.20.70 5 97 2.6E-17 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS23750 bbfeaea412b80008ae986e8723b0ad0d 395 Pfam PF04055 Radical SAM superfamily 22 159 1.3E-8 T 09-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 TK78_RS23750 bbfeaea412b80008ae986e8723b0ad0d 395 SUPERFAMILY SSF102114 17 87 1.83E-11 T 09-03-2017 TK78_RS04175 84d5ac685d9daf07df4412c180e39cfb 147 Gene3D G3DSA:3.30.530.20 4 110 5.0E-6 T 09-03-2017 IPR023393 START-like domain TK78_RS04175 84d5ac685d9daf07df4412c180e39cfb 147 Pfam PF10604 Polyketide cyclase / dehydrase and lipid transport 4 146 1.4E-23 T 09-03-2017 IPR019587 Polyketide cyclase/dehydrase TK78_RS04175 84d5ac685d9daf07df4412c180e39cfb 147 PIRSF PIRSF017371 1 147 5.2E-73 T 09-03-2017 IPR014488 Uncharacterised conserved protein UCP017371 TK78_RS04175 84d5ac685d9daf07df4412c180e39cfb 147 SUPERFAMILY SSF55961 5 139 2.13E-19 T 09-03-2017 TK78_RS02030 1500bb4d2425320545def05f241dbd0c 1308 SUPERFAMILY SSF53300 1144 1295 2.61E-21 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS02030 1500bb4d2425320545def05f241dbd0c 1308 Pfam PF05762 VWA domain containing CoxE-like protein 1082 1302 5.3E-60 T 09-03-2017 IPR008912 Uncharacterised protein family CoxE-like TK78_RS11510 fbfb422b5fcc9ca6b9a175f5bf86c5d0 237 Gene3D G3DSA:1.10.530.10 162 230 3.5E-8 T 09-03-2017 TK78_RS11510 fbfb422b5fcc9ca6b9a175f5bf86c5d0 237 SUPERFAMILY SSF53955 164 231 3.26E-12 T 09-03-2017 IPR023346 Lysozyme-like domain TK78_RS11510 fbfb422b5fcc9ca6b9a175f5bf86c5d0 237 Pfam PF01464 Transglycosylase SLT domain 160 226 3.2E-8 T 09-03-2017 IPR008258 Transglycosylase SLT domain 1 TK78_RS12945 64c0f05ac8640bc3e68b2886f9029c7c 280 Gene3D G3DSA:1.10.260.40 24 74 3.4E-8 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS12945 64c0f05ac8640bc3e68b2886f9029c7c 280 SUPERFAMILY SSF47413 23 74 6.52E-8 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS12945 64c0f05ac8640bc3e68b2886f9029c7c 280 Pfam PF13560 Helix-turn-helix domain 24 78 2.9E-9 T 09-03-2017 TK78_RS12945 64c0f05ac8640bc3e68b2886f9029c7c 280 SMART SM00530 27 82 0.001 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS04790 4c1b986850ca4bfed442aa464c51a02d 294 SUPERFAMILY SSF53335 23 268 5.41E-33 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS04790 4c1b986850ca4bfed442aa464c51a02d 294 Pfam PF02353 Mycolic acid cyclopropane synthetase 79 158 7.2E-10 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS04790 4c1b986850ca4bfed442aa464c51a02d 294 Gene3D G3DSA:3.40.50.150 27 261 4.6E-34 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS32565 69c850fd766a0d2a9736f63a0be26ac6 327 Pfam PF00248 Aldo/keto reductase family 16 315 7.2E-60 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS32565 69c850fd766a0d2a9736f63a0be26ac6 327 Gene3D G3DSA:3.20.20.100 1 317 2.0E-72 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS32565 69c850fd766a0d2a9736f63a0be26ac6 327 SUPERFAMILY SSF51430 1 317 4.32E-74 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS23310 3c9e914240b002a554ce33ec9610b070 177 SUPERFAMILY SSF50475 16 166 4.76E-40 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS23310 3c9e914240b002a554ce33ec9610b070 177 Pfam PF01613 Flavin reductase like domain 24 166 1.2E-30 T 09-03-2017 IPR002563 Flavin reductase like domain GO:0010181 TK78_RS23310 3c9e914240b002a554ce33ec9610b070 177 Gene3D G3DSA:2.30.110.10 16 167 3.4E-45 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS23310 3c9e914240b002a554ce33ec9610b070 177 SMART SM00903 23 165 1.3E-48 T 09-03-2017 IPR002563 Flavin reductase like domain GO:0010181 TK78_RS10530 1ede8819317810f7176cf32bac086150 474 Pfam PF10103 Zinicin-like metallopeptidase 82 434 3.8E-126 T 09-03-2017 IPR018766 Zinicin-like metallopeptidase type 2 TK78_RS10530 1ede8819317810f7176cf32bac086150 474 SUPERFAMILY SSF55486 81 435 4.32E-116 T 09-03-2017 TK78_RS10530 1ede8819317810f7176cf32bac086150 474 TIGRFAM TIGR03624 TIGR03624: putative hydrolase 82 435 1.2E-121 T 09-03-2017 IPR018766 Zinicin-like metallopeptidase type 2 TK78_RS31560 4efd602acc829b344bfbd0100d0b97e4 288 SUPERFAMILY SSF47413 8 70 9.65E-10 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS31560 4efd602acc829b344bfbd0100d0b97e4 288 SMART SM00530 15 70 7.0E-6 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS31560 4efd602acc829b344bfbd0100d0b97e4 288 Pfam PF13560 Helix-turn-helix domain 12 72 3.0E-17 T 09-03-2017 TK78_RS31560 4efd602acc829b344bfbd0100d0b97e4 288 Gene3D G3DSA:1.10.260.40 8 65 3.8E-13 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS21850 2de256c56a1b44123d3434e159df2e14 174 Pfam PF13671 AAA domain 3 119 1.5E-8 T 09-03-2017 TK78_RS21850 2de256c56a1b44123d3434e159df2e14 174 Gene3D G3DSA:3.40.50.300 2 171 2.3E-12 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS21850 2de256c56a1b44123d3434e159df2e14 174 SUPERFAMILY SSF52540 2 169 8.27E-15 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS00615 f88dd3a7382c01871ec0f73f907123b2 229 SUPERFAMILY SSF55166 99 206 2.41E-19 T 09-03-2017 IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain Reactome: R-HSA-373080|Reactome: R-HSA-5358346|Reactome: R-HSA-5362798|Reactome: R-HSA-5632681|Reactome: R-HSA-5658034 TK78_RS00615 f88dd3a7382c01871ec0f73f907123b2 229 Gene3D G3DSA:3.30.1380.10 100 179 2.8E-6 T 09-03-2017 IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain Reactome: R-HSA-373080|Reactome: R-HSA-5358346|Reactome: R-HSA-5362798|Reactome: R-HSA-5632681|Reactome: R-HSA-5658034 TK78_RS00615 f88dd3a7382c01871ec0f73f907123b2 229 Pfam PF02557 D-alanyl-D-alanine carboxypeptidase 102 202 6.4E-10 T 09-03-2017 IPR003709 Peptidase M15B GO:0006508|GO:0008233 TK78_RS32675 cf77ffb02cf35ce2db0a95a83d7c7710 227 Gene3D G3DSA:3.20.20.190 3 219 3.8E-58 T 09-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 TK78_RS32675 cf77ffb02cf35ce2db0a95a83d7c7710 227 Pfam PF03009 Glycerophosphoryl diester phosphodiesterase family 8 218 1.4E-27 T 09-03-2017 IPR030395 Glycerophosphodiester phosphodiesterase domain GO:0006629|GO:0008081 TK78_RS32675 cf77ffb02cf35ce2db0a95a83d7c7710 227 SUPERFAMILY SSF51695 3 219 7.33E-58 T 09-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 TK78_RS03655 8d980c89a8fe2d05eb70efeaf2988ff8 415 Gene3D G3DSA:1.10.10.10 16 87 4.3E-16 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS03655 8d980c89a8fe2d05eb70efeaf2988ff8 415 SUPERFAMILY SSF53067 95 400 7.78E-42 T 09-03-2017 TK78_RS03655 8d980c89a8fe2d05eb70efeaf2988ff8 415 Pfam PF00480 ROK family 95 400 1.8E-43 T 09-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 TK78_RS03655 8d980c89a8fe2d05eb70efeaf2988ff8 415 Gene3D G3DSA:3.30.420.40 239 371 6.8E-44 T 09-03-2017 TK78_RS03655 8d980c89a8fe2d05eb70efeaf2988ff8 415 Gene3D G3DSA:3.30.420.40 94 238 2.4E-33 T 09-03-2017 TK78_RS03655 8d980c89a8fe2d05eb70efeaf2988ff8 415 SUPERFAMILY SSF46785 16 84 3.97E-11 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS17775 d244cc365c6dc945713e19db851e935e 163 Pfam PF04525 LURP-one-related 3 151 5.0E-28 T 09-03-2017 IPR007612 LURP1-related protein domain TK78_RS17775 d244cc365c6dc945713e19db851e935e 163 SUPERFAMILY SSF54518 1 152 3.92E-34 T 09-03-2017 IPR025659 Tubby C-terminal-like domain TK78_RS12105 506c5d8a75dbd1b6d0a9ebf445b0c757 68 Pfam PF04024 PspC domain 4 58 2.8E-18 T 09-03-2017 IPR007168 Phage shock protein, PspC, N-terminal TK78_RS15315 24865e0e02cd4fbf1315e7694662c5b8 156 Pfam PF13581 Histidine kinase-like ATPase domain 8 147 3.8E-32 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS02045 b367582da348641a7c450f0e83137759 286 Pfam PF13569 Domain of unknown function (DUF4132) 25 203 1.3E-30 T 09-03-2017 IPR025406 Domain of unknown function DUF4132 TK78_RS33830 379afbb3fad3bb4eddc6558e53b3801f 210 PIRSF PIRSF001111 1 210 1.4E-94 T 09-03-2017 IPR016291 Isochorismatase GO:0008908 MetaCyc: PWY-5901 TK78_RS33830 379afbb3fad3bb4eddc6558e53b3801f 210 Gene3D G3DSA:3.40.50.850 1 206 6.9E-63 T 09-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 TK78_RS33830 379afbb3fad3bb4eddc6558e53b3801f 210 PRINTS PR01398 Isochorismatase signature 168 186 8.6E-46 T 09-03-2017 IPR016291 Isochorismatase GO:0008908 MetaCyc: PWY-5901 TK78_RS33830 379afbb3fad3bb4eddc6558e53b3801f 210 PRINTS PR01398 Isochorismatase signature 186 203 8.6E-46 T 09-03-2017 IPR016291 Isochorismatase GO:0008908 MetaCyc: PWY-5901 TK78_RS33830 379afbb3fad3bb4eddc6558e53b3801f 210 PRINTS PR01398 Isochorismatase signature 80 99 8.6E-46 T 09-03-2017 IPR016291 Isochorismatase GO:0008908 MetaCyc: PWY-5901 TK78_RS33830 379afbb3fad3bb4eddc6558e53b3801f 210 PRINTS PR01398 Isochorismatase signature 63 80 8.6E-46 T 09-03-2017 IPR016291 Isochorismatase GO:0008908 MetaCyc: PWY-5901 TK78_RS33830 379afbb3fad3bb4eddc6558e53b3801f 210 PRINTS PR01398 Isochorismatase signature 2 14 8.6E-46 T 09-03-2017 IPR016291 Isochorismatase GO:0008908 MetaCyc: PWY-5901 TK78_RS33830 379afbb3fad3bb4eddc6558e53b3801f 210 PRINTS PR01398 Isochorismatase signature 112 134 8.6E-46 T 09-03-2017 IPR016291 Isochorismatase GO:0008908 MetaCyc: PWY-5901 TK78_RS33830 379afbb3fad3bb4eddc6558e53b3801f 210 Pfam PF00857 Isochorismatase family 32 204 2.4E-39 T 09-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 TK78_RS33830 379afbb3fad3bb4eddc6558e53b3801f 210 SUPERFAMILY SSF52499 1 206 1.23E-62 T 09-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 TK78_RS06390 55d6fa8c8c109842dbad91fbf8fc847e 192 Pfam PF10517 Electron transfer DM13 85 189 1.2E-26 T 09-03-2017 IPR019545 DM13 domain TK78_RS19105 c2fdac7a565d0d01d7c9e65d5528e227 487 Gene3D G3DSA:1.20.1250.20 32 222 3.7E-29 T 09-03-2017 TK78_RS19105 c2fdac7a565d0d01d7c9e65d5528e227 487 Gene3D G3DSA:1.20.1250.20 292 472 4.1E-15 T 09-03-2017 TK78_RS19105 c2fdac7a565d0d01d7c9e65d5528e227 487 Pfam PF07690 Major Facilitator Superfamily 38 318 9.3E-22 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS19105 c2fdac7a565d0d01d7c9e65d5528e227 487 SUPERFAMILY SSF103473 21 239 5.1E-48 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS19105 c2fdac7a565d0d01d7c9e65d5528e227 487 SUPERFAMILY SSF103473 276 474 5.1E-48 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS30250 0d7e0263d914e7f88b5f692bf5aa86ae 275 SUPERFAMILY SSF53223 5 104 2.01E-26 T 09-03-2017 TK78_RS30250 0d7e0263d914e7f88b5f692bf5aa86ae 275 SUPERFAMILY SSF51735 105 259 3.53E-21 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS30250 0d7e0263d914e7f88b5f692bf5aa86ae 275 Gene3D G3DSA:3.40.50.720 110 271 8.6E-31 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS30250 0d7e0263d914e7f88b5f692bf5aa86ae 275 Pfam PF08501 Shikimate dehydrogenase substrate binding domain 9 91 1.0E-24 T 09-03-2017 IPR013708 Shikimate dehydrogenase substrate binding, N-terminal GO:0004764|GO:0055114 KEGG: 00400+1.1.1.25|MetaCyc: PWY-6163 TK78_RS30250 0d7e0263d914e7f88b5f692bf5aa86ae 275 Gene3D G3DSA:3.40.192.10 3 109 3.4E-38 T 09-03-2017 TK78_RS04060 885bbc8ab3b237535a93ac8f6711ca77 208 Gene3D G3DSA:1.20.1260.10 54 200 2.7E-25 T 09-03-2017 IPR012347 Ferritin-related TK78_RS04060 885bbc8ab3b237535a93ac8f6711ca77 208 Pfam PF03713 Domain of unknown function (DUF305) 60 200 3.3E-20 T 09-03-2017 IPR005183 Domain of unknown function DUF305 TK78_RS21250 6eb0510e86e4ef0041036cad782db41c 540 SUPERFAMILY SSF50998 128 448 2.22E-12 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS21250 6eb0510e86e4ef0041036cad782db41c 540 Gene3D G3DSA:2.140.10.10 68 331 1.9E-15 T 09-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain TK78_RS21250 6eb0510e86e4ef0041036cad782db41c 540 Gene3D G3DSA:2.140.10.10 392 471 1.9E-15 T 09-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain TK78_RS21250 6eb0510e86e4ef0041036cad782db41c 540 Pfam PF13360 PQQ-like domain 132 278 1.1E-10 T 09-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat TK78_RS24630 f5ba71c536849d15983db0db2be0a441 525 SUPERFAMILY SSF54862 443 501 4.94E-7 T 09-03-2017 TK78_RS24630 f5ba71c536849d15983db0db2be0a441 525 Pfam PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 330 409 6.8E-15 T 09-03-2017 IPR019575 NADH-ubiquinone oxidoreductase 51 kDa subunit, iron-sulphur binding domain GO:0051539 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS24630 f5ba71c536849d15983db0db2be0a441 525 SUPERFAMILY SSF140490 321 419 4.58E-17 T 09-03-2017 TK78_RS24630 f5ba71c536849d15983db0db2be0a441 525 SUPERFAMILY SSF142019 26 239 3.66E-35 T 09-03-2017 TK78_RS24630 f5ba71c536849d15983db0db2be0a441 525 SUPERFAMILY SSF142984 242 316 1.44E-9 T 09-03-2017 TK78_RS24630 f5ba71c536849d15983db0db2be0a441 525 Gene3D G3DSA:3.30.70.20 444 508 8.5E-8 T 09-03-2017 TK78_RS24630 f5ba71c536849d15983db0db2be0a441 525 Pfam PF13459 4Fe-4S single cluster domain 445 501 2.3E-11 T 09-03-2017 TK78_RS24630 f5ba71c536849d15983db0db2be0a441 525 Pfam PF10531 SLBB domain 242 273 4.5E-7 T 09-03-2017 IPR019554 Soluble ligand binding domain Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS24630 f5ba71c536849d15983db0db2be0a441 525 Pfam PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 56 217 2.5E-30 T 09-03-2017 IPR011538 NADH-ubiquinone oxidoreductase 51 kDa subunit, FMN-binding domain Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS24605 8d8c0fa5e30584e0c888df290a4f1541 217 ProSitePatterns PS00175 Phosphoglycerate mutase family phosphohistidine signature. 14 23 - T 09-03-2017 IPR001345 Phosphoglycerate/bisphosphoglycerate mutase, active site GO:0003824|GO:0008152 TK78_RS24605 8d8c0fa5e30584e0c888df290a4f1541 217 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 12 204 1.6E-54 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS24605 8d8c0fa5e30584e0c888df290a4f1541 217 SUPERFAMILY SSF53254 10 208 1.35E-55 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS24605 8d8c0fa5e30584e0c888df290a4f1541 217 Gene3D G3DSA:3.40.50.1240 8 205 1.1E-58 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS24605 8d8c0fa5e30584e0c888df290a4f1541 217 SMART SM00855 11 165 1.5E-22 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS25435 6ab5484876aa64b0e2e46588d563b2bb 344 PIRSF PIRSF005096 14 344 1.9E-101 T 09-03-2017 IPR015443 Aldose 1-epimerase GO:0016853|GO:0019318 KEGG: 00010+5.1.3.3|KEGG: 00052+5.1.3.3|MetaCyc: PWY-6317 TK78_RS25435 6ab5484876aa64b0e2e46588d563b2bb 344 Pfam PF01263 Aldose 1-epimerase 34 339 1.5E-79 T 09-03-2017 IPR008183 Aldose 1-/Glucose-6-phosphate 1-epimerase GO:0005975|GO:0016853 TK78_RS25435 6ab5484876aa64b0e2e46588d563b2bb 344 SUPERFAMILY SSF74650 22 342 1.13E-104 T 09-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 TK78_RS25435 6ab5484876aa64b0e2e46588d563b2bb 344 Gene3D G3DSA:2.70.98.10 17 343 4.9E-114 T 09-03-2017 IPR014718 Glycoside hydrolase-type carbohydrate-binding GO:0003824|GO:0005975|GO:0030246 TK78_RS00100 07d32579b06480ceef25996c97141481 705 Pfam PF01381 Helix-turn-helix 29 74 1.6E-7 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS00100 07d32579b06480ceef25996c97141481 705 Gene3D G3DSA:1.10.260.40 29 74 1.0E-10 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS00100 07d32579b06480ceef25996c97141481 705 SUPERFAMILY SSF47413 29 74 9.29E-8 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS19960 e5d08795562e8e223d276df27a5c4d61 271 Pfam PF15698 Phosphatase 7 269 5.2E-116 T 09-03-2017 IPR031423 Uncharacterised phosphatase SCO2771 TK78_RS27915 7140fcd090a682621af50996900781f7 120 SUPERFAMILY SSF54593 2 115 1.65E-15 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS27915 7140fcd090a682621af50996900781f7 120 Gene3D G3DSA:3.10.180.10 3 114 5.5E-12 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS33055 a1d791e116b417537d1377917c1c591f 88 Hamap MF_01479 Transcriptional regulator WhiB [whiB]. 1 77 19.228 T 09-03-2017 IPR003482 Transcription factor WhiB TK78_RS33055 a1d791e116b417537d1377917c1c591f 88 Pfam PF02467 Transcription factor WhiB 4 72 2.3E-27 T 09-03-2017 IPR003482 Transcription factor WhiB TK78_RS00705 f4e0c2eab45fcd3ff5e506012e9f5f1b 434 Gene3D G3DSA:3.40.190.10 154 321 1.9E-40 T 09-03-2017 TK78_RS00705 f4e0c2eab45fcd3ff5e506012e9f5f1b 434 SUPERFAMILY SSF53850 24 341 7.02E-66 T 09-03-2017 TK78_RS00705 f4e0c2eab45fcd3ff5e506012e9f5f1b 434 Pfam PF01547 Bacterial extracellular solute-binding protein 52 336 2.4E-40 T 09-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 TK78_RS00705 f4e0c2eab45fcd3ff5e506012e9f5f1b 434 Gene3D G3DSA:3.40.190.10 322 344 2.3E-30 T 09-03-2017 TK78_RS00705 f4e0c2eab45fcd3ff5e506012e9f5f1b 434 Gene3D G3DSA:3.40.190.10 31 150 2.3E-30 T 09-03-2017 TK78_RS09895 9fac04bd1941d6b1dbf07b18a1cd3564 487 Pfam PF00905 Penicillin binding protein transpeptidase domain 155 480 2.0E-62 T 09-03-2017 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 TK78_RS09895 9fac04bd1941d6b1dbf07b18a1cd3564 487 Gene3D G3DSA:3.40.710.10 143 486 1.3E-91 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS09895 9fac04bd1941d6b1dbf07b18a1cd3564 487 Gene3D G3DSA:3.90.1310.10 73 142 4.5E-6 T 09-03-2017 TK78_RS09895 9fac04bd1941d6b1dbf07b18a1cd3564 487 SUPERFAMILY SSF56601 140 484 2.32E-83 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS18615 e07c55896cee6f955d0dcf91dd66d8da 292 SUPERFAMILY SSF89392 120 277 2.16E-9 T 09-03-2017 IPR029046 Lipoprotein localisation LolA/LolB/LppX TK78_RS01015 de3ffeda427a312f4e9d334e2fe0871a 356 PIRSF PIRSF015921 14 356 4.5E-70 T 09-03-2017 IPR012171 Fatty acid desaturase GO:0006629|GO:0016021|GO:0016491 TK78_RS01015 de3ffeda427a312f4e9d334e2fe0871a 356 Pfam PF00487 Fatty acid desaturase 76 334 7.1E-38 T 09-03-2017 IPR005804 Fatty acid desaturase domain GO:0006629 TK78_RS25300 5037fc20cd27ec5dcf65ff037f6b5364 568 TIGRFAM TIGR02547 casA_cse1: CRISPR type I-E/ECOLI-associated protein CasA/Cse1 6 447 2.3E-35 T 09-03-2017 IPR013381 CRISPR-associated protein Cse1 TK78_RS25300 5037fc20cd27ec5dcf65ff037f6b5364 568 Pfam PF09481 CRISPR-associated protein Cse1 (CRISPR_cse1) 7 503 1.0E-99 T 09-03-2017 IPR013381 CRISPR-associated protein Cse1 TK78_RS27130 a097199f656e7ba1a7d577dcc95af99b 213 Pfam PF04472 Protein of unknown function (DUF552) 125 196 3.6E-27 T 09-03-2017 IPR007561 Cell division protein SepF/SepF-related GO:0090529 TK78_RS27130 a097199f656e7ba1a7d577dcc95af99b 213 Hamap MF_01197 Cell division protein SepF [sepF]. 2 204 22.614 T 09-03-2017 IPR023052 Cell division protein SepF GO:0090529 TK78_RS10675 149216a635cc6b2b2abe543b8233e048 213 SUPERFAMILY SSF48498 92 204 1.14E-26 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS10675 149216a635cc6b2b2abe543b8233e048 213 SUPERFAMILY SSF46689 12 93 3.89E-21 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS10675 149216a635cc6b2b2abe543b8233e048 213 Pfam PF00440 Bacterial regulatory proteins, tetR family 26 72 1.6E-16 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS10675 149216a635cc6b2b2abe543b8233e048 213 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 47 70 2.2E-10 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS10675 149216a635cc6b2b2abe543b8233e048 213 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 26 39 2.2E-10 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS10675 149216a635cc6b2b2abe543b8233e048 213 Gene3D G3DSA:1.10.357.10 11 203 2.4E-41 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS06865 df4c94d03742c2a2d2ce57d40ff25d3e 262 Pfam PF11361 Protein of unknown function (DUF3159) 46 232 3.4E-55 T 09-03-2017 IPR016566 Uncharacterised conserved protein UCP010219 TK78_RS06865 df4c94d03742c2a2d2ce57d40ff25d3e 262 PIRSF PIRSF010219 19 246 1.7E-81 T 09-03-2017 IPR016566 Uncharacterised conserved protein UCP010219 TK78_RS04445 e7416f1c268f9ebdfa6dc1b4c3d0bcaa 60 Gene3D G3DSA:3.40.630.30 5 59 6.8E-8 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS04445 e7416f1c268f9ebdfa6dc1b4c3d0bcaa 60 SUPERFAMILY SSF55729 5 55 1.0E-6 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS18605 c2eb266a12833889a788293ce278d073 243 SMART SM00014 70 181 9.7E-14 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS18605 c2eb266a12833889a788293ce278d073 243 Pfam PF01569 PAP2 superfamily 77 181 2.9E-18 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS18605 c2eb266a12833889a788293ce278d073 243 Gene3D G3DSA:1.20.144.10 12 180 1.9E-29 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS18605 c2eb266a12833889a788293ce278d073 243 SUPERFAMILY SSF48317 11 184 1.44E-31 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS18625 04edd3afdd0413cc3d0341276dd68911 136 Pfam PF02583 Metal-sensitive transcriptional repressor 51 131 3.6E-30 T 09-03-2017 IPR003735 Metal-sensitive transcriptional repressor GO:0003677|GO:0006355|GO:0046872 TK78_RS15275 298cd09027707db9860dbd2e9c49dc16 509 Gene3D G3DSA:3.40.50.1820 376 496 2.3E-61 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS15275 298cd09027707db9860dbd2e9c49dc16 509 Gene3D G3DSA:3.40.50.1820 64 149 2.3E-61 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS15275 298cd09027707db9860dbd2e9c49dc16 509 Gene3D G3DSA:3.40.50.1820 193 317 2.3E-61 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS15275 298cd09027707db9860dbd2e9c49dc16 509 Pfam PF00561 alpha/beta hydrolase fold 98 481 1.3E-38 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS15275 298cd09027707db9860dbd2e9c49dc16 509 SUPERFAMILY SSF53474 195 249 3.18E-25 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS15275 298cd09027707db9860dbd2e9c49dc16 509 SUPERFAMILY SSF53474 91 150 3.18E-25 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS15275 298cd09027707db9860dbd2e9c49dc16 509 SUPERFAMILY SSF53474 358 496 3.18E-25 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS05015 af12e573c5ebd24f3583c809a246e37c 279 Gene3D G3DSA:1.10.10.10 15 69 2.2E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05015 af12e573c5ebd24f3583c809a246e37c 279 Pfam PF07702 UTRA domain 97 232 8.5E-38 T 09-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 TK78_RS05015 af12e573c5ebd24f3583c809a246e37c 279 SMART SM00866 92 232 5.4E-35 T 09-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 TK78_RS05015 af12e573c5ebd24f3583c809a246e37c 279 Gene3D G3DSA:3.40.1410.10 70 236 1.8E-43 T 09-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain TK78_RS05015 af12e573c5ebd24f3583c809a246e37c 279 Pfam PF00392 Bacterial regulatory proteins, gntR family 15 72 8.5E-16 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS05015 af12e573c5ebd24f3583c809a246e37c 279 SUPERFAMILY SSF64288 60 237 1.44E-42 T 09-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain TK78_RS05015 af12e573c5ebd24f3583c809a246e37c 279 SUPERFAMILY SSF46785 13 79 5.17E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05015 af12e573c5ebd24f3583c809a246e37c 279 SMART SM00345 15 72 5.4E-16 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS05015 af12e573c5ebd24f3583c809a246e37c 279 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 32 46 1.6E-8 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS05015 af12e573c5ebd24f3583c809a246e37c 279 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 46 62 1.6E-8 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS04405 294a25b94f1f9ab227cc944bf447a044 472 Pfam PF13450 NAD(P)-binding Rossmann-like domain 9 57 1.5E-11 T 09-03-2017 TK78_RS04405 294a25b94f1f9ab227cc944bf447a044 472 Gene3D G3DSA:3.50.50.60 435 469 1.2E-9 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS04405 294a25b94f1f9ab227cc944bf447a044 472 Gene3D G3DSA:3.50.50.60 203 286 1.2E-9 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS04405 294a25b94f1f9ab227cc944bf447a044 472 Gene3D G3DSA:3.40.50.720 4 56 2.0E-17 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS04405 294a25b94f1f9ab227cc944bf447a044 472 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 6 28 1.7E-5 T 09-03-2017 TK78_RS04405 294a25b94f1f9ab227cc944bf447a044 472 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 288 309 1.7E-5 T 09-03-2017 TK78_RS04405 294a25b94f1f9ab227cc944bf447a044 472 SUPERFAMILY SSF51905 424 468 6.04E-31 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS04405 294a25b94f1f9ab227cc944bf447a044 472 SUPERFAMILY SSF51905 5 300 6.04E-31 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS17285 eb565ef586bd1a824690a1749d3f8c6a 764 ProSitePatterns PS00430 TonB-dependent receptor proteins signature 1. 1 82 - T 09-03-2017 IPR010916 TonB box, conserved site TK78_RS17855 8564f5b3466c72ebff6ea722cf5be795 689 SUPERFAMILY SSF63829 548 629 1.86E-7 T 09-03-2017 TK78_RS17855 8564f5b3466c72ebff6ea722cf5be795 689 SUPERFAMILY SSF63829 415 509 1.86E-7 T 09-03-2017 TK78_RS17855 8564f5b3466c72ebff6ea722cf5be795 689 Pfam PF05787 Bacterial protein of unknown function (DUF839) 107 650 8.2E-172 T 09-03-2017 IPR008557 Protein of unknown function DUF839 TK78_RS17855 8564f5b3466c72ebff6ea722cf5be795 689 Gene3D G3DSA:2.120.10.30 675 684 1.5E-5 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS17855 8564f5b3466c72ebff6ea722cf5be795 689 Gene3D G3DSA:2.120.10.30 577 599 1.5E-5 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS17855 8564f5b3466c72ebff6ea722cf5be795 689 Gene3D G3DSA:2.120.10.30 436 527 1.5E-5 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS24020 fc1d93a22fb0c31cba324126ee6d2dcd 222 Gene3D G3DSA:3.40.50.2300 2 127 5.8E-39 T 09-03-2017 TK78_RS24020 fc1d93a22fb0c31cba324126ee6d2dcd 222 SMART SM00448 3 118 4.7E-28 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS24020 fc1d93a22fb0c31cba324126ee6d2dcd 222 SUPERFAMILY SSF46894 139 217 1.43E-20 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS24020 fc1d93a22fb0c31cba324126ee6d2dcd 222 Pfam PF00072 Response regulator receiver domain 5 119 4.4E-28 T 09-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TK78_RS24020 fc1d93a22fb0c31cba324126ee6d2dcd 222 Pfam PF00196 Bacterial regulatory proteins, luxR family 156 211 1.5E-17 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS24020 fc1d93a22fb0c31cba324126ee6d2dcd 222 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 187 199 5.2E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS24020 fc1d93a22fb0c31cba324126ee6d2dcd 222 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 157 171 5.2E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS24020 fc1d93a22fb0c31cba324126ee6d2dcd 222 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 171 187 5.2E-11 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS24020 fc1d93a22fb0c31cba324126ee6d2dcd 222 SUPERFAMILY SSF52172 2 137 1.42E-33 T 09-03-2017 IPR011006 CheY-like superfamily TK78_RS24020 fc1d93a22fb0c31cba324126ee6d2dcd 222 SMART SM00421 154 211 1.8E-21 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS24020 fc1d93a22fb0c31cba324126ee6d2dcd 222 Gene3D G3DSA:1.10.10.10 128 218 1.6E-29 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS10885 bbd79584f242b4b6b9a5e4bd8b39b3dd 326 SMART SM00418 251 326 3.0E-4 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS10885 bbd79584f242b4b6b9a5e4bd8b39b3dd 326 Pfam PF12840 Helix-turn-helix domain 253 308 1.1E-6 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS10885 bbd79584f242b4b6b9a5e4bd8b39b3dd 326 Gene3D G3DSA:1.10.10.10 252 316 1.5E-11 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS10885 bbd79584f242b4b6b9a5e4bd8b39b3dd 326 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 284 299 9.8E-5 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS10885 bbd79584f242b4b6b9a5e4bd8b39b3dd 326 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 253 268 9.8E-5 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS10885 bbd79584f242b4b6b9a5e4bd8b39b3dd 326 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 299 314 9.8E-5 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS10885 bbd79584f242b4b6b9a5e4bd8b39b3dd 326 SUPERFAMILY SSF46785 250 316 2.94E-13 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS23715 e3160fff94bc23f10c31767a3784d06a 284 SUPERFAMILY SSF103481 204 280 1.44E-8 T 09-03-2017 TK78_RS23715 e3160fff94bc23f10c31767a3784d06a 284 Pfam PF00892 EamA-like transporter family 143 280 8.3E-16 T 09-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 TK78_RS23715 e3160fff94bc23f10c31767a3784d06a 284 Pfam PF00892 EamA-like transporter family 6 130 6.0E-15 T 09-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 TK78_RS23715 e3160fff94bc23f10c31767a3784d06a 284 SUPERFAMILY SSF103481 38 133 5.1E-12 T 09-03-2017 TK78_RS29390 80ad43d21442547e13344b018a11c657 123 Pfam PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 30 120 7.4E-31 T 09-03-2017 IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain GO:0006457 TK78_RS29390 80ad43d21442547e13344b018a11c657 123 Gene3D G3DSA:3.10.50.40 12 123 1.9E-41 T 09-03-2017 TK78_RS29390 80ad43d21442547e13344b018a11c657 123 SUPERFAMILY SSF54534 16 123 1.04E-38 T 09-03-2017 TK78_RS22710 6542a1c9dc1836d9a35c35431a6bff3b 106 Pfam PF00893 Small Multidrug Resistance protein 1 93 3.9E-26 T 09-03-2017 IPR000390 Small multidrug resistance protein family GO:0016021 TK78_RS22710 6542a1c9dc1836d9a35c35431a6bff3b 106 SUPERFAMILY SSF103481 6 104 1.57E-17 T 09-03-2017 TK78_RS04295 94254b2457ee50b129cd91fa6a668bba 189 Pfam PF13556 PucR C-terminal helix-turn-helix domain 117 174 2.3E-21 T 09-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain TK78_RS04295 94254b2457ee50b129cd91fa6a668bba 189 SUPERFAMILY SSF46689 112 152 9.68E-5 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS04295 94254b2457ee50b129cd91fa6a668bba 189 Gene3D G3DSA:1.10.10.60 112 152 8.2E-6 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS34090 5e9163014adf899bd6cda5c8c5cbfe15 254 SMART SM00382 35 222 5.0E-14 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS34090 5e9163014adf899bd6cda5c8c5cbfe15 254 Pfam PF00005 ABC transporter 26 174 1.1E-30 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS34090 5e9163014adf899bd6cda5c8c5cbfe15 254 SUPERFAMILY SSF52540 10 244 4.71E-70 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS34090 5e9163014adf899bd6cda5c8c5cbfe15 254 PIRSF PIRSF039085 7 250 7.3E-98 T 09-03-2017 IPR030679 ABC-type amino acid transport system, ATPase component, HisP-type GO:0003333|GO:0015424 TK78_RS34090 5e9163014adf899bd6cda5c8c5cbfe15 254 Gene3D G3DSA:3.40.50.300 9 245 3.7E-78 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS34090 5e9163014adf899bd6cda5c8c5cbfe15 254 ProSitePatterns PS00211 ABC transporters family signature. 146 160 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS22205 2b4317d24873749cd4ef9abf3c7cced9 380 SUPERFAMILY SSF53756 5 375 1.1E-65 T 09-03-2017 TK78_RS22205 2b4317d24873749cd4ef9abf3c7cced9 380 Gene3D G3DSA:3.40.50.2000 197 356 2.5E-26 T 09-03-2017 TK78_RS22205 2b4317d24873749cd4ef9abf3c7cced9 380 Pfam PF00534 Glycosyl transferases group 1 202 356 1.4E-36 T 09-03-2017 IPR001296 Glycosyl transferase, family 1 TK78_RS12145 e8a5031d79bf57280c7156b88159516f 344 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 28 201 1.4E-24 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12145 e8a5031d79bf57280c7156b88159516f 344 Pfam PF04542 Sigma-70 region 2 28 90 7.5E-19 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12145 e8a5031d79bf57280c7156b88159516f 344 SUPERFAMILY SSF88946 21 102 2.08E-21 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12145 e8a5031d79bf57280c7156b88159516f 344 Gene3D G3DSA:3.10.450.50 214 331 7.3E-19 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS12145 e8a5031d79bf57280c7156b88159516f 344 Pfam PF12680 SnoaL-like domain 222 316 1.1E-6 T 09-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain TK78_RS12145 e8a5031d79bf57280c7156b88159516f 344 SUPERFAMILY SSF54427 213 329 5.59E-19 T 09-03-2017 IPR032710 NTF2-like domain TK78_RS12145 e8a5031d79bf57280c7156b88159516f 344 Pfam PF08281 Sigma-70, region 4 147 199 6.6E-15 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12145 e8a5031d79bf57280c7156b88159516f 344 SUPERFAMILY SSF88659 143 201 7.29E-12 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12145 e8a5031d79bf57280c7156b88159516f 344 Gene3D G3DSA:1.10.10.10 141 201 1.5E-14 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS12145 e8a5031d79bf57280c7156b88159516f 344 TIGRFAM TIGR02960 SigX5: RNA polymerase sigma-70 factor, TIGR02960 family 20 333 1.0E-146 T 09-03-2017 IPR014305 RNA polymerase sigma-G type, actinobacteria TK78_RS12145 e8a5031d79bf57280c7156b88159516f 344 Gene3D G3DSA:1.10.1740.10 14 105 2.5E-24 T 09-03-2017 TK78_RS27150 889c70e5ce6a05c6556451b2ceda4543 226 SUPERFAMILY SSF109635 93 190 1.7E-10 T 09-03-2017 TK78_RS27150 889c70e5ce6a05c6556451b2ceda4543 226 Pfam PF01258 Prokaryotic dksA/traR C4-type zinc finger 189 224 1.6E-10 T 09-03-2017 IPR000962 Zinc finger, DksA/TraR C4-type GO:0008270 TK78_RS27150 889c70e5ce6a05c6556451b2ceda4543 226 SUPERFAMILY SSF57716 191 225 2.99E-7 T 09-03-2017 TK78_RS21760 a0609a57da5de2a9d14d714f3d8ae141 163 Gene3D G3DSA:3.30.565.10 67 144 3.0E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS21760 a0609a57da5de2a9d14d714f3d8ae141 163 Pfam PF13581 Histidine kinase-like ATPase domain 43 155 2.4E-11 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS21760 a0609a57da5de2a9d14d714f3d8ae141 163 SUPERFAMILY SSF55874 68 157 9.95E-11 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS04740 cdb871e5dc331caf187d465f368e2471 298 Gene3D G3DSA:1.10.3720.10 76 275 7.4E-39 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS04740 cdb871e5dc331caf187d465f368e2471 298 SUPERFAMILY SSF161098 75 263 4.19E-37 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS04740 cdb871e5dc331caf187d465f368e2471 298 TIGRFAM TIGR01726 HEQRo_perm_3TM: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family 76 165 1.8E-18 T 09-03-2017 IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain GO:0005215|GO:0006810|GO:0016021 TK78_RS04740 cdb871e5dc331caf187d465f368e2471 298 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 96 275 2.2E-20 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS34255 03e91e91d4231fe6607d9a2dc8948321 121 SUPERFAMILY SSF159888 7 117 4.45E-23 T 09-03-2017 TK78_RS34255 03e91e91d4231fe6607d9a2dc8948321 121 Pfam PF08818 Domain of unknown function (DU1801) 20 112 1.2E-16 T 09-03-2017 IPR014922 Domain of unknown function DUF1801 TK78_RS10550 1d453262aa836f22f357d8d0bb8c0793 538 Pfam PF01987 Mitochondrial biogenesis AIM24 343 534 3.2E-21 T 09-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 TK78_RS10550 1d453262aa836f22f357d8d0bb8c0793 538 Gene3D G3DSA:2.60.60.30 34 167 9.2E-27 T 09-03-2017 TK78_RS10550 1d453262aa836f22f357d8d0bb8c0793 538 SUPERFAMILY SSF51219 339 537 3.92E-33 T 09-03-2017 IPR016031 Tryptophan RNA-binding attenuator protein-like domain TK78_RS10550 1d453262aa836f22f357d8d0bb8c0793 538 Pfam PF02342 TerD domain 1 170 4.7E-35 T 09-03-2017 IPR003325 TerD domain GO:0006950 TK78_RS10550 1d453262aa836f22f357d8d0bb8c0793 538 Gene3D G3DSA:3.60.160.10 340 534 6.4E-27 T 09-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 TK78_RS29220 7e8920becd865c624ea168bc4551e681 349 TIGRFAM TIGR03559 F420_Rv3520c: probable F420-dependent oxidoreductase, Rv3520c family 2 322 9.5E-118 T 09-03-2017 IPR019951 F420-dependent oxidoreductase-predicted, Rv3520c TK78_RS29220 7e8920becd865c624ea168bc4551e681 349 Pfam PF00296 Luciferase-like monooxygenase 17 318 9.9E-79 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS29220 7e8920becd865c624ea168bc4551e681 349 SUPERFAMILY SSF51679 1 337 1.57E-70 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS29220 7e8920becd865c624ea168bc4551e681 349 Gene3D G3DSA:3.20.20.30 1 337 7.7E-76 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS12330 dc95a5b0c87ef1fdb4c7c0f35bcdedf6 277 Pfam PF14219 Domain of unknown function (DUF4328) 101 251 1.5E-44 T 09-03-2017 IPR025565 Domain of unknown function DUF4328 TK78_RS32425 267de50f9f9aec913e0ef0e175940467 256 TIGRFAM TIGR01444 fkbM_fam: methyltransferase, FkbM family 45 176 1.8E-20 T 09-03-2017 IPR006342 Methyltransferase FkbM TK78_RS32425 267de50f9f9aec913e0ef0e175940467 256 Gene3D G3DSA:3.40.50.150 28 215 1.9E-33 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS32425 267de50f9f9aec913e0ef0e175940467 256 Pfam PF05050 Methyltransferase FkbM domain 56 178 4.8E-11 T 09-03-2017 IPR006342 Methyltransferase FkbM TK78_RS32425 267de50f9f9aec913e0ef0e175940467 256 SUPERFAMILY SSF53335 21 200 5.97E-37 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS03435 d8422e321ae720861c8398d815967ea0 321 Pfam PF03976 Polyphosphate kinase 2 (PPK2) 50 275 1.7E-99 T 09-03-2017 IPR022488 Polyphosphate kinase-2-related TK78_RS03435 d8422e321ae720861c8398d815967ea0 321 SUPERFAMILY SSF52540 80 267 5.16E-26 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03435 d8422e321ae720861c8398d815967ea0 321 Gene3D G3DSA:3.40.50.300 41 292 2.3E-105 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03435 d8422e321ae720861c8398d815967ea0 321 TIGRFAM TIGR03707 PPK2_P_aer: polyphosphate kinase 2 49 276 3.4E-112 T 09-03-2017 IPR022486 Polyphosphate kinase 2, PA0141 GO:0006793|GO:0008976 TK78_RS15700 f1d7bf9b651a450b11e85f59caa3659f 219 Pfam PF16702 Domain of unknown function (DUF5063) 14 173 1.3E-42 T 09-03-2017 IPR032025 Protein of unknown function DUF5063 TK78_RS34260 76bd75cbcd980d6d7b48e4302606242d 169 SUPERFAMILY SSF109854 5 167 4.12E-35 T 09-03-2017 TK78_RS34260 76bd75cbcd980d6d7b48e4302606242d 169 Gene3D G3DSA:1.20.120.450 1 167 5.5E-67 T 09-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase TK78_RS34260 76bd75cbcd980d6d7b48e4302606242d 169 Pfam PF04978 Protein of unknown function (DUF664) 7 166 3.3E-18 T 09-03-2017 IPR007061 Protein of unknown function DUF664 TK78_RS12335 0df41e36f95bd6c1d42ec95289473a6e 536 Pfam PF02838 Glycosyl hydrolase family 20, domain 2 64 182 2.3E-18 T 09-03-2017 IPR015882 Beta-hexosaminidase, bacteial type, N-terminal KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 TK78_RS12335 0df41e36f95bd6c1d42ec95289473a6e 536 PRINTS PR00738 Glycosyl hydrolase family 20 signature 477 493 8.9E-22 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS12335 0df41e36f95bd6c1d42ec95289473a6e 536 PRINTS PR00738 Glycosyl hydrolase family 20 signature 148 168 8.9E-22 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS12335 0df41e36f95bd6c1d42ec95289473a6e 536 PRINTS PR00738 Glycosyl hydrolase family 20 signature 257 274 8.9E-22 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS12335 0df41e36f95bd6c1d42ec95289473a6e 536 PRINTS PR00738 Glycosyl hydrolase family 20 signature 321 334 8.9E-22 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS12335 0df41e36f95bd6c1d42ec95289473a6e 536 PRINTS PR00738 Glycosyl hydrolase family 20 signature 180 197 8.9E-22 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS12335 0df41e36f95bd6c1d42ec95289473a6e 536 PRINTS PR00738 Glycosyl hydrolase family 20 signature 299 317 8.9E-22 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS12335 0df41e36f95bd6c1d42ec95289473a6e 536 SUPERFAMILY SSF51445 187 527 8.85E-75 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS12335 0df41e36f95bd6c1d42ec95289473a6e 536 Gene3D G3DSA:3.30.379.10 64 173 3.1E-18 T 09-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS12335 0df41e36f95bd6c1d42ec95289473a6e 536 SUPERFAMILY SSF55545 64 185 9.81E-16 T 09-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS12335 0df41e36f95bd6c1d42ec95289473a6e 536 Gene3D G3DSA:3.20.20.80 174 527 9.5E-74 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS12335 0df41e36f95bd6c1d42ec95289473a6e 536 Pfam PF00728 Glycosyl hydrolase family 20, catalytic domain 189 495 5.2E-42 T 09-03-2017 IPR015883 Glycoside hydrolase family 20, catalytic domain GO:0004553|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 TK78_RS25680 dbba37ce3989c514cb65248779fac96d 217 Pfam PF00583 Acetyltransferase (GNAT) family 148 202 2.4E-4 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS25680 dbba37ce3989c514cb65248779fac96d 217 Gene3D G3DSA:3.40.630.30 142 206 3.9E-7 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS25680 dbba37ce3989c514cb65248779fac96d 217 Gene3D G3DSA:3.40.630.30 21 43 3.9E-7 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS25680 dbba37ce3989c514cb65248779fac96d 217 SUPERFAMILY SSF55729 142 206 5.12E-7 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS10960 7adc3e0e39bcc563aa467e446ec59855 325 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C 48 91 1.5E-10 T 09-03-2017 IPR025966 Oligopeptide transport permease C-like, N-terminal domain TK78_RS10960 7adc3e0e39bcc563aa467e446ec59855 325 Gene3D G3DSA:1.10.3720.10 115 322 1.5E-27 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS10960 7adc3e0e39bcc563aa467e446ec59855 325 SUPERFAMILY SSF161098 119 310 2.75E-24 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS10960 7adc3e0e39bcc563aa467e446ec59855 325 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 141 325 5.3E-27 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS01710 26a39be1045e212af3b1b6134f0cd180 281 ProSitePatterns PS00211 ABC transporters family signature. 148 162 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS01710 26a39be1045e212af3b1b6134f0cd180 281 Pfam PF00005 ABC transporter 27 175 4.4E-31 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS01710 26a39be1045e212af3b1b6134f0cd180 281 SMART SM00382 36 225 8.1E-19 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS01710 26a39be1045e212af3b1b6134f0cd180 281 SUPERFAMILY SSF52540 12 238 1.38E-63 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01710 26a39be1045e212af3b1b6134f0cd180 281 Gene3D G3DSA:3.40.50.300 8 241 1.1E-68 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS32415 5afc0e89ab25bdbeb2e2ce967997bb88 432 Gene3D G3DSA:2.30.40.10 392 426 1.1E-15 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS32415 5afc0e89ab25bdbeb2e2ce967997bb88 432 Gene3D G3DSA:2.30.40.10 55 115 1.1E-15 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS32415 5afc0e89ab25bdbeb2e2ce967997bb88 432 Pfam PF01979 Amidohydrolase family 110 423 1.8E-27 T 09-03-2017 IPR006680 Amidohydrolase-related GO:0016787 TK78_RS32415 5afc0e89ab25bdbeb2e2ce967997bb88 432 SUPERFAMILY SSF51338 392 422 1.32E-12 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS32415 5afc0e89ab25bdbeb2e2ce967997bb88 432 SUPERFAMILY SSF51338 55 114 1.32E-12 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS32415 5afc0e89ab25bdbeb2e2ce967997bb88 432 Gene3D G3DSA:3.20.20.140 116 388 1.2E-49 T 09-03-2017 TK78_RS32415 5afc0e89ab25bdbeb2e2ce967997bb88 432 SUPERFAMILY SSF51556 114 392 6.81E-56 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS30160 0915d4fad0bbf9c6722344294eb15dfd 409 Pfam PF03993 Domain of Unknown Function (DUF349) 245 318 1.3E-20 T 09-03-2017 IPR007139 Protein of unknown function DUF349 TK78_RS30160 0915d4fad0bbf9c6722344294eb15dfd 409 Pfam PF03993 Domain of Unknown Function (DUF349) 91 164 3.6E-13 T 09-03-2017 IPR007139 Protein of unknown function DUF349 TK78_RS30160 0915d4fad0bbf9c6722344294eb15dfd 409 Pfam PF03993 Domain of Unknown Function (DUF349) 168 241 8.6E-21 T 09-03-2017 IPR007139 Protein of unknown function DUF349 TK78_RS14790 39f1dd414b732d8e50f710aeee3621f7 414 Pfam PF13360 PQQ-like domain 196 358 2.1E-20 T 09-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat TK78_RS14790 39f1dd414b732d8e50f710aeee3621f7 414 Pfam PF13360 PQQ-like domain 75 183 2.7E-7 T 09-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat TK78_RS14790 39f1dd414b732d8e50f710aeee3621f7 414 SUPERFAMILY SSF50998 74 411 3.06E-31 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS14790 39f1dd414b732d8e50f710aeee3621f7 414 SMART SM00564 90 120 32.0 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS14790 39f1dd414b732d8e50f710aeee3621f7 414 SMART SM00564 128 162 22.0 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS14790 39f1dd414b732d8e50f710aeee3621f7 414 SMART SM00564 224 256 67.0 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS14790 39f1dd414b732d8e50f710aeee3621f7 414 SMART SM00564 348 383 3.3E-5 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS14790 39f1dd414b732d8e50f710aeee3621f7 414 SMART SM00564 305 336 0.006 T 09-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat TK78_RS14790 39f1dd414b732d8e50f710aeee3621f7 414 Gene3D G3DSA:2.140.10.10 33 412 1.6E-45 T 09-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain TK78_RS01875 b12c9457d99e26038b4a7fac383f0e11 426 Pfam PF06808 Tripartite ATP-independent periplasmic transporter, DctM component 13 413 1.5E-9 T 09-03-2017 IPR010656 TRAP C4-dicarboxylate transport system permease DctM subunit TK78_RS20470 d5a5725741ca16ccda34840a732a439d 528 PIRSF PIRSF006060 27 515 4.2E-51 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS20470 d5a5725741ca16ccda34840a732a439d 528 Pfam PF13520 Amino acid permease 46 446 6.8E-29 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS11635 6e05024bf90df56951decfbe92052404 145 Pfam PF07811 TadE-like protein 27 69 1.7E-6 T 09-03-2017 IPR012495 TadE-like TK78_RS05310 624e224a6edb280ebe964e13a9c74e12 144 SUPERFAMILY SSF53933 50 143 6.8E-38 T 09-03-2017 IPR016191 Ribonuclease/ribotoxin GO:0003723|GO:0004540 TK78_RS05310 624e224a6edb280ebe964e13a9c74e12 144 Pfam PF00545 ribonuclease 59 137 1.8E-29 T 09-03-2017 IPR000026 Guanine-specific ribonuclease N1/T1/U2 GO:0003723|GO:0004521 TK78_RS05310 624e224a6edb280ebe964e13a9c74e12 144 Gene3D G3DSA:3.10.450.30 51 142 1.8E-41 T 09-03-2017 IPR016191 Ribonuclease/ribotoxin GO:0003723|GO:0004540 TK78_RS25110 67a12fd60ca14c5473909db227a5f84b 170 SUPERFAMILY SSF50475 16 122 1.27E-22 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS25110 67a12fd60ca14c5473909db227a5f84b 170 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 23 109 4.9E-14 T 09-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS25110 67a12fd60ca14c5473909db227a5f84b 170 Gene3D G3DSA:2.30.110.10 22 126 5.7E-21 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS22400 e41317602b9772a72eaf4fe6e594d045 569 SUPERFAMILY SSF51445 162 528 1.59E-118 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS22400 e41317602b9772a72eaf4fe6e594d045 569 SUPERFAMILY SSF55545 15 161 1.26E-20 T 09-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS22400 e41317602b9772a72eaf4fe6e594d045 569 Gene3D G3DSA:3.20.20.80 160 551 5.2E-139 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS22400 e41317602b9772a72eaf4fe6e594d045 569 Pfam PF02838 Glycosyl hydrolase family 20, domain 2 18 158 1.2E-18 T 09-03-2017 IPR015882 Beta-hexosaminidase, bacteial type, N-terminal KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 TK78_RS22400 e41317602b9772a72eaf4fe6e594d045 569 Pfam PF00728 Glycosyl hydrolase family 20, catalytic domain 162 512 6.2E-124 T 09-03-2017 IPR015883 Glycoside hydrolase family 20, catalytic domain GO:0004553|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 TK78_RS22400 e41317602b9772a72eaf4fe6e594d045 569 Gene3D G3DSA:3.30.379.10 11 159 5.5E-28 T 09-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS22400 e41317602b9772a72eaf4fe6e594d045 569 PRINTS PR00738 Glycosyl hydrolase family 20 signature 112 132 1.2E-36 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS22400 e41317602b9772a72eaf4fe6e594d045 569 PRINTS PR00738 Glycosyl hydrolase family 20 signature 307 325 1.2E-36 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS22400 e41317602b9772a72eaf4fe6e594d045 569 PRINTS PR00738 Glycosyl hydrolase family 20 signature 332 345 1.2E-36 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS22400 e41317602b9772a72eaf4fe6e594d045 569 PRINTS PR00738 Glycosyl hydrolase family 20 signature 256 273 1.2E-36 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS22400 e41317602b9772a72eaf4fe6e594d045 569 PRINTS PR00738 Glycosyl hydrolase family 20 signature 494 511 1.2E-36 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS22400 e41317602b9772a72eaf4fe6e594d045 569 PRINTS PR00738 Glycosyl hydrolase family 20 signature 185 206 1.2E-36 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS22400 e41317602b9772a72eaf4fe6e594d045 569 PRINTS PR00738 Glycosyl hydrolase family 20 signature 476 492 1.2E-36 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS21775 4ca0e91fb3b68ca66827363247012564 361 Gene3D G3DSA:2.60.40.230 49 123 3.4E-5 T 09-03-2017 IPR027273 Neocarzinostatin-like TK78_RS21775 4ca0e91fb3b68ca66827363247012564 361 SUPERFAMILY SSF49319 49 140 4.32E-6 T 09-03-2017 IPR027273 Neocarzinostatin-like TK78_RS24045 7008a542f58ec398e735573cf3e372a4 630 Pfam PF01926 50S ribosome-binding GTPase 126 248 3.0E-8 T 09-03-2017 IPR006073 GTP binding domain GO:0005525 TK78_RS24045 7008a542f58ec398e735573cf3e372a4 630 SUPERFAMILY SSF52540 115 324 9.11E-23 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS24045 7008a542f58ec398e735573cf3e372a4 630 Gene3D G3DSA:3.40.50.300 109 325 3.1E-25 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17890 0ffde25ab3d6c3eb3446438847f0bf81 285 Pfam PF01061 ABC-2 type transporter 44 251 6.1E-32 T 09-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 TK78_RS17890 0ffde25ab3d6c3eb3446438847f0bf81 285 PIRSF PIRSF006648 20 285 6.2E-74 T 09-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 TK78_RS06080 b5dad9a912ffce2e024f1e9060b695ca 150 Pfam PF01042 Endoribonuclease L-PSP 27 135 2.2E-15 T 09-03-2017 IPR006175 YjgF/YER057c/UK114 family TK78_RS06080 b5dad9a912ffce2e024f1e9060b695ca 150 SUPERFAMILY SSF55298 24 135 1.57E-22 T 09-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like TK78_RS06080 b5dad9a912ffce2e024f1e9060b695ca 150 Gene3D G3DSA:3.30.1330.40 20 139 2.0E-25 T 09-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like TK78_RS05100 7cb29fa16e05d12dd0a4531ace5043ee 378 Pfam PF06224 Winged helix DNA-binding domain 42 358 1.8E-66 T 09-03-2017 IPR009351 Protein of unknown function DUF1006 TK78_RS04375 1e3bde053556b86f8c0807d756e21d1b 633 SMART SM00065 91 242 3.1E-24 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS04375 1e3bde053556b86f8c0807d756e21d1b 633 Gene3D G3DSA:3.30.450.40 68 245 1.5E-35 T 09-03-2017 IPR029016 GAF domain-like TK78_RS04375 1e3bde053556b86f8c0807d756e21d1b 633 Pfam PF13185 GAF domain 90 233 3.3E-17 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS04375 1e3bde053556b86f8c0807d756e21d1b 633 Pfam PF13556 PucR C-terminal helix-turn-helix domain 568 626 5.1E-17 T 09-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain TK78_RS04375 1e3bde053556b86f8c0807d756e21d1b 633 SUPERFAMILY SSF55781 74 260 5.45E-31 T 09-03-2017 IPR029016 GAF domain-like TK78_RS08915 b5404c143c43ae415ff020dede1916e7 208 SUPERFAMILY SSF46689 7 82 1.12E-14 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS08915 b5404c143c43ae415ff020dede1916e7 208 Pfam PF00440 Bacterial regulatory proteins, tetR family 20 62 9.1E-10 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS08915 b5404c143c43ae415ff020dede1916e7 208 Gene3D G3DSA:1.10.357.10 8 169 1.3E-29 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS23400 edd7f5eccb470b449cd643219dfe0a1f 425 SUPERFAMILY SSF51905 7 265 1.55E-17 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS23400 edd7f5eccb470b449cd643219dfe0a1f 425 SUPERFAMILY SSF51905 263 411 1.85E-9 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS23400 edd7f5eccb470b449cd643219dfe0a1f 425 SUPERFAMILY SSF51905 136 201 1.85E-9 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS23400 edd7f5eccb470b449cd643219dfe0a1f 425 Gene3D G3DSA:3.50.50.60 90 206 2.8E-13 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS23400 edd7f5eccb470b449cd643219dfe0a1f 425 Pfam PF13434 L-lysine 6-monooxygenase (NADPH-requiring) 7 339 3.0E-123 T 09-03-2017 IPR025700 L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase TK78_RS06540 fc1b8b3b4d71a95ce699a501b393970b 505 SUPERFAMILY SSF48173 223 484 1.19E-51 T 09-03-2017 IPR005101 Cryptochrome/DNA photolyase, FAD-binding domain Reactome: R-HSA-1368108|Reactome: R-HSA-400253 TK78_RS06540 fc1b8b3b4d71a95ce699a501b393970b 505 Gene3D G3DSA:1.10.579.10 311 402 6.5E-4 T 09-03-2017 TK78_RS06540 fc1b8b3b4d71a95ce699a501b393970b 505 Gene3D G3DSA:1.25.40.80 195 310 1.3E-14 T 09-03-2017 TK78_RS06540 fc1b8b3b4d71a95ce699a501b393970b 505 Pfam PF04244 Deoxyribodipyrimidine photo-lyase-related protein 7 206 3.7E-37 T 09-03-2017 IPR007357 Deoxyribodipyrimidine photolyase-related protein TK78_RS21595 9c65654d365b90983d867cde460743b2 461 SUPERFAMILY SSF51905 103 123 1.21E-12 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS21595 9c65654d365b90983d867cde460743b2 461 SUPERFAMILY SSF51905 162 268 1.21E-12 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS21595 9c65654d365b90983d867cde460743b2 461 SUPERFAMILY SSF51905 263 347 2.28E-26 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS21595 9c65654d365b90983d867cde460743b2 461 SUPERFAMILY SSF51905 5 175 2.28E-26 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS21595 9c65654d365b90983d867cde460743b2 461 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 106 124 3.2E-7 T 09-03-2017 TK78_RS21595 9c65654d365b90983d867cde460743b2 461 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 9 28 3.2E-7 T 09-03-2017 TK78_RS21595 9c65654d365b90983d867cde460743b2 461 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 166 184 3.2E-7 T 09-03-2017 TK78_RS21595 9c65654d365b90983d867cde460743b2 461 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 8 336 8.8E-44 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS21595 9c65654d365b90983d867cde460743b2 461 Gene3D G3DSA:3.50.50.60 270 349 2.7E-28 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS21595 9c65654d365b90983d867cde460743b2 461 Gene3D G3DSA:3.50.50.60 6 112 2.7E-28 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS21595 9c65654d365b90983d867cde460743b2 461 Gene3D G3DSA:3.50.50.60 113 269 3.4E-19 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS24525 185481b6bec2a521009fb0ae2eba54f7 106 Pfam PF00829 Ribosomal prokaryotic L21 protein 2 101 2.4E-31 T 09-03-2017 IPR028909 Ribosomal protein L21-like GO:0005840 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS24525 185481b6bec2a521009fb0ae2eba54f7 106 Hamap MF_01363 50S ribosomal protein L21 [rplU]. 1 103 22.621 T 09-03-2017 IPR001787 Ribosomal protein L21 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS24525 185481b6bec2a521009fb0ae2eba54f7 106 TIGRFAM TIGR00061 L21: ribosomal protein bL21 2 101 1.9E-26 T 09-03-2017 IPR001787 Ribosomal protein L21 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS24525 185481b6bec2a521009fb0ae2eba54f7 106 SUPERFAMILY SSF141091 1 101 3.27E-30 T 09-03-2017 IPR028909 Ribosomal protein L21-like GO:0005840 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS24525 185481b6bec2a521009fb0ae2eba54f7 106 ProSitePatterns PS01169 Ribosomal protein L21 signature. 72 94 - T 09-03-2017 IPR018258 Ribosomal protein L21, conserved site GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS10520 9a802b96f34bbbdb82557276c246d720 153 Pfam PF02391 MoaE protein 22 133 4.5E-37 T 09-03-2017 IPR003448 Molybdopterin biosynthesis MoaE GO:0006777 KEGG: 00790+2.8.1.12|MetaCyc: PWY-6823|Reactome: R-HSA-947581 TK78_RS10520 9a802b96f34bbbdb82557276c246d720 153 SUPERFAMILY SSF54690 20 151 1.44E-41 T 09-03-2017 IPR003448 Molybdopterin biosynthesis MoaE GO:0006777 KEGG: 00790+2.8.1.12|MetaCyc: PWY-6823|Reactome: R-HSA-947581 TK78_RS10520 9a802b96f34bbbdb82557276c246d720 153 Gene3D G3DSA:3.90.1170.40 17 151 1.3E-47 T 09-03-2017 IPR003448 Molybdopterin biosynthesis MoaE GO:0006777 KEGG: 00790+2.8.1.12|MetaCyc: PWY-6823|Reactome: R-HSA-947581 TK78_RS31290 eb2b65d9ad4167138f8a49be36dd905a 188 SUPERFAMILY SSF52540 18 179 1.07E-13 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31290 eb2b65d9ad4167138f8a49be36dd905a 188 Gene3D G3DSA:3.40.50.300 18 180 2.8E-18 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS31290 eb2b65d9ad4167138f8a49be36dd905a 188 Pfam PF07931 Chloramphenicol phosphotransferase-like protein 17 138 5.2E-7 T 09-03-2017 IPR012853 Chloramphenicol phosphotransferase-like GO:0005524|GO:0016740 TK78_RS04640 c55d8d66f245be5c4a446c2d39144b6b 335 SUPERFAMILY SSF51735 6 328 1.83E-93 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS04640 c55d8d66f245be5c4a446c2d39144b6b 335 Pfam PF16363 GDP-mannose 4,6 dehydratase 14 317 8.6E-68 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS04640 c55d8d66f245be5c4a446c2d39144b6b 335 Gene3D G3DSA:3.90.25.10 197 325 4.3E-30 T 09-03-2017 TK78_RS04640 c55d8d66f245be5c4a446c2d39144b6b 335 Gene3D G3DSA:3.40.50.720 12 196 1.2E-61 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS01595 5587df082d02a1035486cffda8c715e4 219 SUPERFAMILY SSF46689 5 85 4.62E-16 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS01595 5587df082d02a1035486cffda8c715e4 219 Gene3D G3DSA:1.10.357.10 4 187 1.1E-26 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS01595 5587df082d02a1035486cffda8c715e4 219 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 35 58 2.1E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS01595 5587df082d02a1035486cffda8c715e4 219 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 14 27 2.1E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS01595 5587df082d02a1035486cffda8c715e4 219 Pfam PF00440 Bacterial regulatory proteins, tetR family 14 60 1.5E-11 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS34315 a68ebbac35534339787147dd4f5fca4d 414 Pfam PF00144 Beta-lactamase 69 382 2.7E-54 T 09-03-2017 IPR001466 Beta-lactamase-related TK78_RS34315 a68ebbac35534339787147dd4f5fca4d 414 SUPERFAMILY SSF56601 60 382 7.52E-62 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS34315 a68ebbac35534339787147dd4f5fca4d 414 Gene3D G3DSA:3.40.710.10 76 386 1.5E-63 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS27030 56d13cef119b7348068a6053b0a589e2 252 SUPERFAMILY SSF53335 15 205 5.58E-29 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS27030 56d13cef119b7348068a6053b0a589e2 252 Gene3D G3DSA:3.40.50.150 27 250 2.4E-27 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS27030 56d13cef119b7348068a6053b0a589e2 252 Pfam PF13649 Methyltransferase domain 38 134 6.9E-14 T 09-03-2017 TK78_RS23205 f72d35e450d5a4de636ef3f6b18d8676 338 SUPERFAMILY SSF161098 86 316 7.06E-60 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS23205 f72d35e450d5a4de636ef3f6b18d8676 338 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 118 326 4.5E-22 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS23205 f72d35e450d5a4de636ef3f6b18d8676 338 Gene3D G3DSA:1.20.58.370 37 70 5.6E-4 T 09-03-2017 TK78_RS23205 f72d35e450d5a4de636ef3f6b18d8676 338 SUPERFAMILY SSF160964 37 70 2.75E-5 T 09-03-2017 TK78_RS23205 f72d35e450d5a4de636ef3f6b18d8676 338 Gene3D G3DSA:1.10.3720.10 92 321 1.5E-60 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS07055 cdcf8fc90353356781d7700f98642dc7 298 SUPERFAMILY SSF52151 11 115 3.14E-25 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS07055 cdcf8fc90353356781d7700f98642dc7 298 SUPERFAMILY SSF52151 186 275 3.14E-25 T 09-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 TK78_RS07055 cdcf8fc90353356781d7700f98642dc7 298 Gene3D G3DSA:3.40.366.10 16 109 2.6E-22 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS07055 cdcf8fc90353356781d7700f98642dc7 298 Gene3D G3DSA:3.40.366.10 184 276 2.6E-22 T 09-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 TK78_RS29525 5a7109796b125b081bbfb7c14272166d 236 Gene3D G3DSA:3.40.50.1980 2 98 1.7E-20 T 09-03-2017 TK78_RS29525 5a7109796b125b081bbfb7c14272166d 236 Gene3D G3DSA:3.40.50.1980 129 234 4.7E-13 T 09-03-2017 TK78_RS29525 5a7109796b125b081bbfb7c14272166d 236 SUPERFAMILY SSF53807 2 235 3.41E-34 T 09-03-2017 TK78_RS10655 808904b12b7f7ba9bc55037c25d08fdd 629 Gene3D G3DSA:3.40.50.2000 338 510 3.0E-18 T 09-03-2017 TK78_RS10655 808904b12b7f7ba9bc55037c25d08fdd 629 Pfam PF13692 Glycosyl transferases group 1 340 497 2.9E-23 T 09-03-2017 TK78_RS10655 808904b12b7f7ba9bc55037c25d08fdd 629 Pfam PF11997 Domain of unknown function (DUF3492) 2 301 1.6E-27 T 09-03-2017 IPR022622 Domain of unknown function DUF3492 TK78_RS10655 808904b12b7f7ba9bc55037c25d08fdd 629 SUPERFAMILY SSF53756 2 88 8.57E-54 T 09-03-2017 TK78_RS10655 808904b12b7f7ba9bc55037c25d08fdd 629 SUPERFAMILY SSF53756 207 529 8.57E-54 T 09-03-2017 TK78_RS25615 c021cbbd1c3378debd45e5d201f29ef7 191 Pfam PF02342 TerD domain 1 186 3.6E-81 T 09-03-2017 IPR003325 TerD domain GO:0006950 TK78_RS25615 c021cbbd1c3378debd45e5d201f29ef7 191 Gene3D G3DSA:2.60.60.30 18 183 5.4E-72 T 09-03-2017 TK78_RS05585 da774e86d0f6bbf061b6fe897e7847f8 399 Gene3D G3DSA:3.40.50.2000 8 237 2.1E-15 T 09-03-2017 TK78_RS05585 da774e86d0f6bbf061b6fe897e7847f8 399 TIGRFAM TIGR01426 MGT: glycosyltransferase, MGT family 12 398 1.2E-134 T 09-03-2017 IPR006326 UDP-glycosyltransferase, MGT GO:0016758|GO:0016999 TK78_RS05585 da774e86d0f6bbf061b6fe897e7847f8 399 ProSitePatterns PS00375 UDP-glycosyltransferases signature. 289 330 - T 09-03-2017 IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase GO:0008152|GO:0016758 TK78_RS05585 da774e86d0f6bbf061b6fe897e7847f8 399 Pfam PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 223 377 1.7E-17 T 09-03-2017 IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase GO:0008152|GO:0016758 TK78_RS05585 da774e86d0f6bbf061b6fe897e7847f8 399 SUPERFAMILY SSF53756 8 395 3.38E-79 T 09-03-2017 TK78_RS05585 da774e86d0f6bbf061b6fe897e7847f8 399 Gene3D G3DSA:3.40.50.2000 238 380 1.3E-34 T 09-03-2017 TK78_RS15165 fc2d2ba78b5dd83d9f95688c948ea458 511 Pfam PF13745 HxxPF-repeated domain 401 491 6.4E-12 T 09-03-2017 TK78_RS15165 fc2d2ba78b5dd83d9f95688c948ea458 511 Pfam PF00668 Condensation domain 81 376 1.4E-47 T 09-03-2017 IPR001242 Condensation domain TK78_RS15165 fc2d2ba78b5dd83d9f95688c948ea458 511 SUPERFAMILY SSF52777 81 259 1.33E-42 T 09-03-2017 TK78_RS15165 fc2d2ba78b5dd83d9f95688c948ea458 511 SUPERFAMILY SSF52777 268 505 1.41E-41 T 09-03-2017 TK78_RS32015 d44b0facb992b46cf9ec14efde9a1dd7 297 Pfam PF09995 Uncharacterized protein conserved in bacteria (DUF2236) 44 271 7.5E-51 T 09-03-2017 IPR018713 Domain of unknown function DUF2236 TK78_RS14230 a73f8d431ef5a7f15d15d4825ed0e252 274 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 11 148 1.4E-30 T 09-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 TK78_RS14230 a73f8d431ef5a7f15d15d4825ed0e252 274 Gene3D G3DSA:1.20.120.450 6 150 2.9E-10 T 09-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase TK78_RS14230 a73f8d431ef5a7f15d15d4825ed0e252 274 Pfam PF08608 Wyosine base formation 186 231 1.3E-4 T 09-03-2017 IPR013917 tRNA wybutosine-synthesis MetaCyc: PWY-7285|MetaCyc: PWY-7286 TK78_RS14230 a73f8d431ef5a7f15d15d4825ed0e252 274 TIGRFAM TIGR03083 TIGR03083: uncharacterized Actinobacterial protein TIGR03083 10 225 1.7E-49 T 09-03-2017 IPR017517 Conserved hypothetical protein CHP03083, actinobacterial-type TK78_RS14230 a73f8d431ef5a7f15d15d4825ed0e252 274 SUPERFAMILY SSF109854 5 153 2.9E-36 T 09-03-2017 TK78_RS14230 a73f8d431ef5a7f15d15d4825ed0e252 274 TIGRFAM TIGR03084 TIGR03084: TIGR03084 family protein 6 258 5.2E-107 T 09-03-2017 IPR017518 Conserved hypothetical protein CHP03084 TK78_RS29140 c7f8d7d39454668ccf087878f60f0123 323 Gene3D G3DSA:1.25.40.10 59 181 1.6E-5 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS29140 c7f8d7d39454668ccf087878f60f0123 323 Gene3D G3DSA:1.25.40.10 268 291 1.6E-5 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS23125 a77320dcc857082f92e445c019a6addd 232 Pfam PF09250 Bifunctional DNA primase/polymerase, N-terminal 17 182 6.3E-7 T 09-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal TK78_RS12830 d83dbc02eb39904b3d62ed7fe0b43182 172 Pfam PF00583 Acetyltransferase (GNAT) family 62 135 4.9E-16 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS12830 d83dbc02eb39904b3d62ed7fe0b43182 172 Gene3D G3DSA:3.40.630.30 8 158 6.7E-33 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS12830 d83dbc02eb39904b3d62ed7fe0b43182 172 TIGRFAM TIGR01575 rimI: ribosomal-protein-alanine acetyltransferase 17 154 5.7E-29 T 09-03-2017 IPR006464 Ribosomal-protein-alanine acetyltransferase GO:0006474|GO:0016407 TK78_RS12830 d83dbc02eb39904b3d62ed7fe0b43182 172 SUPERFAMILY SSF55729 8 160 7.32E-31 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS14205 216efeb678ed3a9ce70d9a0d638aef50 530 Gene3D G3DSA:3.30.300.30 424 525 4.0E-30 T 09-03-2017 TK78_RS14205 216efeb678ed3a9ce70d9a0d638aef50 530 SUPERFAMILY SSF56801 13 523 4.06E-148 T 09-03-2017 TK78_RS14205 216efeb678ed3a9ce70d9a0d638aef50 530 Gene3D G3DSA:3.40.50.980 183 341 3.5E-50 T 09-03-2017 TK78_RS14205 216efeb678ed3a9ce70d9a0d638aef50 530 Pfam PF00501 AMP-binding enzyme 25 427 2.3E-100 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS14205 216efeb678ed3a9ce70d9a0d638aef50 530 ProSitePatterns PS00455 Putative AMP-binding domain signature. 177 188 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS14205 216efeb678ed3a9ce70d9a0d638aef50 530 Gene3D G3DSA:3.40.50.980 17 182 1.4E-32 T 09-03-2017 TK78_RS14205 216efeb678ed3a9ce70d9a0d638aef50 530 Pfam PF13193 AMP-binding enzyme C-terminal domain 436 512 1.5E-15 T 09-03-2017 IPR025110 AMP-binding enzyme C-terminal domain TK78_RS14205 216efeb678ed3a9ce70d9a0d638aef50 530 Gene3D G3DSA:2.30.38.10 342 418 1.8E-27 T 09-03-2017 TK78_RS28695 de2d1146efbd79d2ae2ce5d435ff4702 147 SUPERFAMILY SSF55961 5 136 8.54E-25 T 09-03-2017 TK78_RS28695 de2d1146efbd79d2ae2ce5d435ff4702 147 Gene3D G3DSA:3.30.530.20 6 115 1.7E-11 T 09-03-2017 IPR023393 START-like domain TK78_RS28695 de2d1146efbd79d2ae2ce5d435ff4702 147 Pfam PF03364 Polyketide cyclase / dehydrase and lipid transport 11 115 3.7E-14 T 09-03-2017 IPR005031 Coenzyme Q-binding protein COQ10, START domain TK78_RS09135 a85895a2d77df227668df47c2556f09c 240 Pfam PF00196 Bacterial regulatory proteins, luxR family 179 234 4.7E-12 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS09135 a85895a2d77df227668df47c2556f09c 240 SUPERFAMILY SSF46894 167 240 1.39E-16 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS09135 a85895a2d77df227668df47c2556f09c 240 SMART SM00421 177 234 1.2E-15 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS09135 a85895a2d77df227668df47c2556f09c 240 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 180 194 3.0E-7 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS09135 a85895a2d77df227668df47c2556f09c 240 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 210 222 3.0E-7 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS09135 a85895a2d77df227668df47c2556f09c 240 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 194 210 3.0E-7 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS09135 a85895a2d77df227668df47c2556f09c 240 Gene3D G3DSA:1.10.10.10 139 240 8.9E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS34740 c8337ef52a6df0a8c43fbe542e10cbe9 102 Gene3D G3DSA:1.10.10.10 8 64 1.3E-18 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS34740 c8337ef52a6df0a8c43fbe542e10cbe9 102 SUPERFAMILY SSF46785 8 65 2.73E-13 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS34740 c8337ef52a6df0a8c43fbe542e10cbe9 102 Pfam PF01726 LexA DNA binding domain 8 64 1.5E-16 T 09-03-2017 IPR006199 LexA repressor, DNA-binding domain GO:0004252|GO:0006508 TK78_RS14020 c879d208e637b4a9f4966752a4c08f98 490 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 213 359 1.4E-5 T 09-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 TK78_RS14020 c879d208e637b4a9f4966752a4c08f98 490 Pfam PF13490 Putative zinc-finger 132 162 1.2E-5 T 09-03-2017 IPR027383 Putative zinc-finger TK78_RS14020 c879d208e637b4a9f4966752a4c08f98 490 SUPERFAMILY SSF109854 203 365 6.18E-16 T 09-03-2017 TK78_RS12465 ccdbecbe0df4eddedbbe5f266972c83a 398 SUPERFAMILY SSF47413 16 78 1.47E-5 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS12465 ccdbecbe0df4eddedbbe5f266972c83a 398 Pfam PF10901 Protein of unknown function (DUF2690) 295 383 8.8E-22 T 09-03-2017 IPR021224 Protein of unknown function DUF2690 TK78_RS12465 ccdbecbe0df4eddedbbe5f266972c83a 398 SMART SM00530 21 76 0.0011 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS12465 ccdbecbe0df4eddedbbe5f266972c83a 398 Gene3D G3DSA:1.10.260.40 18 76 3.7E-5 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS12465 ccdbecbe0df4eddedbbe5f266972c83a 398 Pfam PF13560 Helix-turn-helix domain 17 74 4.7E-11 T 09-03-2017 TK78_RS29355 25b7070a6f6cd178aed0f9f866d94646 63 Pfam PF02945 Recombination endonuclease VII 3 38 4.3E-8 T 09-03-2017 IPR004211 Recombination endonuclease VII TK78_RS29355 25b7070a6f6cd178aed0f9f866d94646 63 SUPERFAMILY SSF54060 5 33 8.95E-6 T 09-03-2017 TK78_RS33710 19c89f68fffcfbc718e6b8526af50645 433 PIRSF PIRSF000880 11 431 1.1E-97 T 09-03-2017 IPR016273 Erythromycin esterase, proteobacteria TK78_RS33710 19c89f68fffcfbc718e6b8526af50645 433 Gene3D G3DSA:3.30.1870.10 73 140 1.2E-5 T 09-03-2017 TK78_RS33710 19c89f68fffcfbc718e6b8526af50645 433 Pfam PF05139 Erythromycin esterase 71 423 1.4E-53 T 09-03-2017 IPR007815 Erythromycin esterase GO:0046677 TK78_RS33710 19c89f68fffcfbc718e6b8526af50645 433 Gene3D G3DSA:3.40.1660.10 288 426 4.2E-42 T 09-03-2017 TK78_RS33710 19c89f68fffcfbc718e6b8526af50645 433 Gene3D G3DSA:3.40.1660.10 6 71 4.2E-42 T 09-03-2017 TK78_RS33710 19c89f68fffcfbc718e6b8526af50645 433 SUPERFAMILY SSF159501 7 427 4.19E-74 T 09-03-2017 TK78_RS11695 12455c4c17a66aeaaf027d703883e6ad 539 Gene3D G3DSA:2.30.40.10 1 72 1.3E-16 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS11695 12455c4c17a66aeaaf027d703883e6ad 539 Pfam PF07969 Amidohydrolase family 47 519 1.1E-59 T 09-03-2017 IPR013108 Amidohydrolase 3 TK78_RS11695 12455c4c17a66aeaaf027d703883e6ad 539 SUPERFAMILY SSF51556 346 474 6.57E-75 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS11695 12455c4c17a66aeaaf027d703883e6ad 539 SUPERFAMILY SSF51556 59 301 6.57E-75 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS11695 12455c4c17a66aeaaf027d703883e6ad 539 Gene3D G3DSA:2.30.40.10 459 532 2.6E-11 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS11695 12455c4c17a66aeaaf027d703883e6ad 539 Gene3D G3DSA:3.20.20.140 398 458 2.0E-113 T 09-03-2017 TK78_RS11695 12455c4c17a66aeaaf027d703883e6ad 539 Gene3D G3DSA:3.20.20.140 73 293 2.0E-113 T 09-03-2017 TK78_RS11695 12455c4c17a66aeaaf027d703883e6ad 539 SUPERFAMILY SSF51338 474 525 1.24E-21 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS11695 12455c4c17a66aeaaf027d703883e6ad 539 SUPERFAMILY SSF51338 1 59 1.24E-21 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS03540 9af84a57076ca785bad7709069cf9915 157 Gene3D G3DSA:3.30.1050.10 45 153 4.6E-21 T 09-03-2017 IPR003033 SCP2 sterol-binding domain TK78_RS03540 9af84a57076ca785bad7709069cf9915 157 SUPERFAMILY SSF55718 52 155 3.53E-18 T 09-03-2017 IPR003033 SCP2 sterol-binding domain TK78_RS03540 9af84a57076ca785bad7709069cf9915 157 Pfam PF02036 SCP-2 sterol transfer family 63 152 2.3E-13 T 09-03-2017 IPR003033 SCP2 sterol-binding domain TK78_RS32895 5cb410d96a0d0db33c35cbc44478ab62 393 Gene3D G3DSA:3.90.550.10 42 254 1.7E-20 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS32895 5cb410d96a0d0db33c35cbc44478ab62 393 SUPERFAMILY SSF53448 31 255 2.53E-34 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS32895 5cb410d96a0d0db33c35cbc44478ab62 393 Pfam PF13641 Glycosyltransferase like family 2 42 255 5.2E-21 T 09-03-2017 TK78_RS32895 5cb410d96a0d0db33c35cbc44478ab62 393 TIGRFAM TIGR03469 HpnB: hopene-associated glycosyltransferase HpnB 6 385 1.1E-145 T 09-03-2017 IPR017832 Glycosyl transferase, family 2, hopene-associated, HpnB TK78_RS09450 af37e0329fd905299536c56828a82844 108 Pfam PF12823 Domain of unknown function (DUF3817) 6 92 3.6E-26 T 09-03-2017 IPR023845 Domain of unknown function DUF3817, transmembrane TK78_RS09450 af37e0329fd905299536c56828a82844 108 TIGRFAM TIGR03954 integ_memb_HG: integral membrane protein 9 90 3.5E-26 T 09-03-2017 IPR023845 Domain of unknown function DUF3817, transmembrane TK78_RS02770 ed4788d7c43c4b37e1faea88b7754b85 306 SUPERFAMILY SSF53167 54 304 4.23E-22 T 09-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 TK78_RS02770 ed4788d7c43c4b37e1faea88b7754b85 306 Pfam PF01048 Phosphorylase superfamily 54 302 1.3E-13 T 09-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 TK78_RS02770 ed4788d7c43c4b37e1faea88b7754b85 306 Gene3D G3DSA:3.40.50.1580 54 303 2.9E-37 T 09-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 TK78_RS24700 dd0094fe540859ede0b9a14c6d50f4bb 410 SUPERFAMILY SSF103473 11 408 7.46E-41 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS24700 dd0094fe540859ede0b9a14c6d50f4bb 410 Pfam PF07690 Major Facilitator Superfamily 21 287 7.8E-15 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS24700 dd0094fe540859ede0b9a14c6d50f4bb 410 Gene3D G3DSA:1.20.1250.20 19 201 5.1E-16 T 09-03-2017 TK78_RS24700 dd0094fe540859ede0b9a14c6d50f4bb 410 Gene3D G3DSA:1.20.1250.20 228 408 6.2E-15 T 09-03-2017 TK78_RS20170 ab5928ff8241675ce4c43ead43555b4d 357 SUPERFAMILY SSF50331 238 344 3.32E-12 T 09-03-2017 IPR008995 Molybdate/tungstate binding, C-terminal TK78_RS20170 ab5928ff8241675ce4c43ead43555b4d 357 SMART SM00382 29 212 7.5E-19 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS20170 ab5928ff8241675ce4c43ead43555b4d 357 SUPERFAMILY SSF52540 5 244 6.55E-86 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS20170 ab5928ff8241675ce4c43ead43555b4d 357 Pfam PF00005 ABC transporter 20 162 9.6E-33 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS20170 ab5928ff8241675ce4c43ead43555b4d 357 Gene3D G3DSA:3.40.50.300 5 234 6.5E-79 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS20170 ab5928ff8241675ce4c43ead43555b4d 357 Pfam PF08402 TOBE domain 273 341 3.2E-9 T 09-03-2017 IPR013611 Transport-associated OB, type 2 GO:0005215|GO:0005524|GO:0006810|GO:0016820|GO:0043190 TK78_RS20170 ab5928ff8241675ce4c43ead43555b4d 357 ProSitePatterns PS00211 ABC transporters family signature. 135 149 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS22485 d25259b3013adcb20684ff8d4fd6c36b 262 Pfam PF05362 Lon protease (S16) C-terminal proteolytic domain 154 245 2.9E-7 T 09-03-2017 IPR008269 Peptidase S16, Lon C-terminal GO:0004176|GO:0004252|GO:0006508 TK78_RS22485 d25259b3013adcb20684ff8d4fd6c36b 262 SUPERFAMILY SSF54211 114 250 1.78E-19 T 09-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold TK78_RS22485 d25259b3013adcb20684ff8d4fd6c36b 262 Gene3D G3DSA:3.30.230.10 109 247 4.3E-23 T 09-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TK78_RS04735 e03743cd2145eb2ba0c7f8d3010bf152 402 Pfam PF03734 L,D-transpeptidase catalytic domain 248 370 4.5E-11 T 09-03-2017 IPR005490 L,D-transpeptidase catalytic domain GO:0016740 TK78_RS04735 e03743cd2145eb2ba0c7f8d3010bf152 402 SUPERFAMILY SSF141523 248 370 1.44E-21 T 09-03-2017 TK78_RS04735 e03743cd2145eb2ba0c7f8d3010bf152 402 Gene3D G3DSA:2.40.440.10 248 370 9.6E-15 T 09-03-2017 TK78_RS27470 1eca2588a988ab185bc791dfd51753d4 541 Pfam PF00270 DEAD/DEAH box helicase 106 274 8.4E-42 T 09-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 TK78_RS27470 1eca2588a988ab185bc791dfd51753d4 541 Gene3D G3DSA:3.40.50.300 291 444 5.5E-42 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27470 1eca2588a988ab185bc791dfd51753d4 541 Gene3D G3DSA:3.40.50.300 79 290 1.4E-66 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27470 1eca2588a988ab185bc791dfd51753d4 541 SUPERFAMILY SSF52540 154 439 5.4E-64 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27470 1eca2588a988ab185bc791dfd51753d4 541 SMART SM00487 101 301 2.3E-47 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS27470 1eca2588a988ab185bc791dfd51753d4 541 Pfam PF00271 Helicase conserved C-terminal domain 319 417 1.9E-24 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS27470 1eca2588a988ab185bc791dfd51753d4 541 SMART SM00490 336 417 6.4E-28 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS17255 f2265ade9d22ac86ce5fd76ad75be3c4 807 SUPERFAMILY SSF53955 56 274 2.22E-58 T 09-03-2017 IPR023346 Lysozyme-like domain TK78_RS17255 f2265ade9d22ac86ce5fd76ad75be3c4 807 Pfam PF00912 Transglycosylase 70 250 9.4E-51 T 09-03-2017 IPR001264 Glycosyl transferase, family 51 TK78_RS17255 f2265ade9d22ac86ce5fd76ad75be3c4 807 Pfam PF00905 Penicillin binding protein transpeptidase domain 359 625 3.8E-25 T 09-03-2017 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 TK78_RS17255 f2265ade9d22ac86ce5fd76ad75be3c4 807 SUPERFAMILY SSF56601 286 687 6.8E-77 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS17255 f2265ade9d22ac86ce5fd76ad75be3c4 807 SUPERFAMILY SSF56601 236 256 6.8E-77 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS17255 f2265ade9d22ac86ce5fd76ad75be3c4 807 Gene3D G3DSA:3.40.710.10 254 715 2.1E-95 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS17255 f2265ade9d22ac86ce5fd76ad75be3c4 807 Gene3D G3DSA:1.10.3810.10 69 253 2.5E-57 T 09-03-2017 TK78_RS30960 58de7c618d32f1d96cab4b27f9d58ed5 222 SUPERFAMILY SSF52499 11 210 2.62E-37 T 09-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 TK78_RS30960 58de7c618d32f1d96cab4b27f9d58ed5 222 Pfam PF00857 Isochorismatase family 19 204 1.2E-23 T 09-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 TK78_RS30960 58de7c618d32f1d96cab4b27f9d58ed5 222 Gene3D G3DSA:3.40.50.850 11 212 9.1E-38 T 09-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 TK78_RS28790 63094f5c4fbbae382781f595e1778ff1 147 Hamap MF_01197 Cell division protein SepF [sepF]. 1 138 19.331 T 09-03-2017 IPR023052 Cell division protein SepF GO:0090529 TK78_RS28790 63094f5c4fbbae382781f595e1778ff1 147 Pfam PF04472 Protein of unknown function (DUF552) 59 130 7.6E-24 T 09-03-2017 IPR007561 Cell division protein SepF/SepF-related GO:0090529 TK78_RS22670 0ce45a1caa7f98f1550ab2010db2123a 200 SUPERFAMILY SSF52972 1 196 2.25E-65 T 09-03-2017 IPR029001 Inosine triphosphate pyrophosphatase-like TK78_RS22670 0ce45a1caa7f98f1550ab2010db2123a 200 TIGRFAM TIGR00042 TIGR00042: non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family 4 192 2.7E-51 T 09-03-2017 IPR002637 Ham1-like protein GO:0016787 KEGG: 00230+3.6.1.19|KEGG: 00240+3.6.1.19|KEGG: 00983+3.6.1.19|MetaCyc: PWY-7206|Reactome: R-HSA-15869 TK78_RS22670 0ce45a1caa7f98f1550ab2010db2123a 200 Hamap MF_01405 dITP/XTP pyrophosphatase [rdgB]. 2 197 46.075 T 09-03-2017 IPR020922 Non-canonical purine NTP pyrophosphatase GO:0009143|GO:0017111 KEGG: 00230+3.6.1.19|KEGG: 00240+3.6.1.19|KEGG: 00983+3.6.1.19|MetaCyc: PWY-7206 TK78_RS22670 0ce45a1caa7f98f1550ab2010db2123a 200 Pfam PF01725 Ham1 family 4 192 1.7E-52 T 09-03-2017 IPR002637 Ham1-like protein GO:0016787 KEGG: 00230+3.6.1.19|KEGG: 00240+3.6.1.19|KEGG: 00983+3.6.1.19|MetaCyc: PWY-7206|Reactome: R-HSA-15869 TK78_RS22670 0ce45a1caa7f98f1550ab2010db2123a 200 Gene3D G3DSA:3.90.950.10 1 198 7.9E-78 T 09-03-2017 IPR029001 Inosine triphosphate pyrophosphatase-like TK78_RS14520 89a0325e60671d692f2828b3d991b075 253 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 19 251 2.9E-48 T 09-03-2017 TK78_RS14520 89a0325e60671d692f2828b3d991b075 253 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 89 100 4.2E-6 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS14520 89a0325e60671d692f2828b3d991b075 253 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 140 148 4.2E-6 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS14520 89a0325e60671d692f2828b3d991b075 253 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 160 179 4.2E-6 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS14520 89a0325e60671d692f2828b3d991b075 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 181 198 4.2E-22 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS14520 89a0325e60671d692f2828b3d991b075 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 215 235 4.2E-22 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS14520 89a0325e60671d692f2828b3d991b075 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 160 179 4.2E-22 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS14520 89a0325e60671d692f2828b3d991b075 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 89 100 4.2E-22 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS14520 89a0325e60671d692f2828b3d991b075 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 12 29 4.2E-22 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS14520 89a0325e60671d692f2828b3d991b075 253 Gene3D G3DSA:3.40.50.720 4 252 6.7E-66 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS14520 89a0325e60671d692f2828b3d991b075 253 SUPERFAMILY SSF51735 7 252 8.41E-62 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS32030 347db2eecd3edd23507b1fb23523e1d3 136 Gene3D G3DSA:1.10.10.10 2 82 1.4E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32030 347db2eecd3edd23507b1fb23523e1d3 136 Pfam PF01475 Ferric uptake regulator family 11 102 4.6E-23 T 09-03-2017 IPR002481 Ferric-uptake regulator GO:0003700|GO:0006355 TK78_RS32030 347db2eecd3edd23507b1fb23523e1d3 136 SUPERFAMILY SSF46785 3 134 2.96E-30 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS07535 0c55edb73ad56baefae09c30339befc0 282 Gene3D G3DSA:2.60.120.280 31 155 4.1E-13 T 09-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 TK78_RS07535 0c55edb73ad56baefae09c30339befc0 282 SUPERFAMILY SSF51215 31 156 9.02E-21 T 09-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 TK78_RS07535 0c55edb73ad56baefae09c30339befc0 282 Gene3D G3DSA:1.10.10.60 228 275 5.3E-9 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS07535 0c55edb73ad56baefae09c30339befc0 282 Gene3D G3DSA:1.10.10.60 177 227 7.3E-14 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS07535 0c55edb73ad56baefae09c30339befc0 282 Pfam PF02311 AraC-like ligand binding domain 20 152 1.6E-23 T 09-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 TK78_RS07535 0c55edb73ad56baefae09c30339befc0 282 SUPERFAMILY SSF46689 177 224 6.09E-8 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS07535 0c55edb73ad56baefae09c30339befc0 282 Pfam PF12833 Helix-turn-helix domain 196 273 2.4E-19 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS07535 0c55edb73ad56baefae09c30339befc0 282 SUPERFAMILY SSF46689 227 274 2.01E-7 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS07535 0c55edb73ad56baefae09c30339befc0 282 SMART SM00342 190 272 7.4E-25 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS21425 85d8ad5353baedebd9eef15589249878 148 SUPERFAMILY SSF103196 2 130 9.07E-30 T 09-03-2017 TK78_RS21425 85d8ad5353baedebd9eef15589249878 148 Pfam PF03259 Roadblock/LC7 domain 9 101 6.1E-23 T 09-03-2017 IPR004942 Roadblock/LAMTOR2 domain TK78_RS21425 85d8ad5353baedebd9eef15589249878 148 Gene3D G3DSA:3.30.450.30 4 128 7.9E-27 T 09-03-2017 TK78_RS21425 85d8ad5353baedebd9eef15589249878 148 SMART SM00960 9 101 3.1E-25 T 09-03-2017 IPR004942 Roadblock/LAMTOR2 domain TK78_RS33250 8c9dc14382e53750ad6db0afc8fe157e 396 ProSitePatterns PS00137 Serine proteases, subtilase family, histidine active site. 188 198 - T 09-03-2017 IPR022398 Peptidase S8, subtilisin, His-active site TK78_RS33250 8c9dc14382e53750ad6db0afc8fe157e 396 ProSitePatterns PS00138 Serine proteases, subtilase family, serine active site. 339 349 - T 09-03-2017 IPR023828 Peptidase S8, subtilisin, Ser-active site TK78_RS33250 8c9dc14382e53750ad6db0afc8fe157e 396 Gene3D G3DSA:3.40.50.200 124 378 1.6E-82 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS33250 8c9dc14382e53750ad6db0afc8fe157e 396 SUPERFAMILY SSF54897 43 107 1.53E-8 T 09-03-2017 IPR009020 Proteinase propeptide inhibitor TK78_RS33250 8c9dc14382e53750ad6db0afc8fe157e 396 PRINTS PR00723 Subtilisin serine protease family (S8) signature 338 354 2.4E-20 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS33250 8c9dc14382e53750ad6db0afc8fe157e 396 PRINTS PR00723 Subtilisin serine protease family (S8) signature 146 165 2.4E-20 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS33250 8c9dc14382e53750ad6db0afc8fe157e 396 PRINTS PR00723 Subtilisin serine protease family (S8) signature 184 197 2.4E-20 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS33250 8c9dc14382e53750ad6db0afc8fe157e 396 SUPERFAMILY SSF52743 122 376 2.62E-76 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS33250 8c9dc14382e53750ad6db0afc8fe157e 396 Gene3D G3DSA:3.30.70.80 39 108 4.7E-12 T 09-03-2017 IPR010259 Peptidase S8 propeptide/proteinase inhibitor I9 TK78_RS33250 8c9dc14382e53750ad6db0afc8fe157e 396 Pfam PF05922 Peptidase inhibitor I9 72 106 9.5E-6 T 09-03-2017 IPR010259 Peptidase S8 propeptide/proteinase inhibitor I9 TK78_RS33250 8c9dc14382e53750ad6db0afc8fe157e 396 Pfam PF00082 Subtilase family 146 376 8.7E-34 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS33250 8c9dc14382e53750ad6db0afc8fe157e 396 ProSitePatterns PS00136 Serine proteases, subtilase family, aspartic acid active site. 151 162 - T 09-03-2017 IPR023827 Peptidase S8, subtilisin, Asp-active site TK78_RS04045 c99853be7d54a3ca79bfe3babec8dd63 238 SUPERFAMILY SSF53067 105 221 4.91E-7 T 09-03-2017 TK78_RS04045 c99853be7d54a3ca79bfe3babec8dd63 238 Pfam PF06723 MreB/Mbl protein 164 222 1.1E-5 T 09-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 TK78_RS04045 c99853be7d54a3ca79bfe3babec8dd63 238 Pfam PF06723 MreB/Mbl protein 21 132 1.8E-5 T 09-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 TK78_RS04045 c99853be7d54a3ca79bfe3babec8dd63 238 Gene3D G3DSA:3.30.420.40 106 208 1.2E-6 T 09-03-2017 TK78_RS17950 1cd22d3fb60e079fc9bd73927fa8486f 151 SUPERFAMILY SSF158682 15 150 1.83E-24 T 09-03-2017 IPR029024 TerB-like TK78_RS17950 1cd22d3fb60e079fc9bd73927fa8486f 151 Pfam PF05099 Tellurite resistance protein TerB 11 150 1.5E-32 T 09-03-2017 IPR007791 Co-chaperone DjlA, N-terminal TK78_RS17950 1cd22d3fb60e079fc9bd73927fa8486f 151 Gene3D G3DSA:1.10.3680.10 21 150 1.1E-22 T 09-03-2017 IPR029024 TerB-like TK78_RS28455 82d31f7447d030532f5cc341e9cd6a38 434 Gene3D G3DSA:1.10.150.210 226 277 2.8E-25 T 09-03-2017 IPR023190 Phosphoserine phosphatase, domain 2 GO:0004647|GO:0006564 KEGG: 00260+3.1.3.3|KEGG: 00680+3.1.3.3|Reactome: R-HSA-977347 TK78_RS28455 82d31f7447d030532f5cc341e9cd6a38 434 Gene3D G3DSA:3.40.50.1000 278 406 1.1E-44 T 09-03-2017 IPR023214 HAD-like domain TK78_RS28455 82d31f7447d030532f5cc341e9cd6a38 434 SUPERFAMILY SSF55021 43 116 2.14E-8 T 09-03-2017 TK78_RS28455 82d31f7447d030532f5cc341e9cd6a38 434 Pfam PF13740 ACT domain 42 117 7.9E-16 T 09-03-2017 TK78_RS28455 82d31f7447d030532f5cc341e9cd6a38 434 Gene3D G3DSA:3.30.70.260 42 118 1.2E-14 T 09-03-2017 TK78_RS28455 82d31f7447d030532f5cc341e9cd6a38 434 Gene3D G3DSA:3.30.70.260 147 215 2.4E-4 T 09-03-2017 TK78_RS28455 82d31f7447d030532f5cc341e9cd6a38 434 SUPERFAMILY SSF56784 215 422 1.73E-47 T 09-03-2017 IPR023214 HAD-like domain TK78_RS28455 82d31f7447d030532f5cc341e9cd6a38 434 Pfam PF12710 haloacid dehalogenase-like hydrolase 217 384 7.4E-24 T 09-03-2017 TK78_RS28455 82d31f7447d030532f5cc341e9cd6a38 434 TIGRFAM TIGR01488 HAD-SF-IB: HAD phosphoserine phosphatase-like hydrolase, family IB 216 385 7.2E-30 T 09-03-2017 IPR006383 HAD-superfamily hydrolase, subfamily IB, PSPase-like GO:0008152|GO:0016791 TK78_RS28455 82d31f7447d030532f5cc341e9cd6a38 434 TIGRFAM TIGR00338 serB: phosphoserine phosphatase SerB 207 419 4.2E-77 T 09-03-2017 TK78_RS25775 406415f1e89c42fb9753969ad6b81371 417 SUPERFAMILY SSF48264 2 412 2.49E-83 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS25775 406415f1e89c42fb9753969ad6b81371 417 Gene3D G3DSA:1.10.630.10 6 413 7.5E-113 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS25775 406415f1e89c42fb9753969ad6b81371 417 Pfam PF00067 Cytochrome P450 292 381 3.2E-16 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS25775 406415f1e89c42fb9753969ad6b81371 417 PRINTS PR00359 B-class P450 signature 334 349 7.5E-47 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS25775 406415f1e89c42fb9753969ad6b81371 417 PRINTS PR00359 B-class P450 signature 306 333 7.5E-47 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS25775 406415f1e89c42fb9753969ad6b81371 417 PRINTS PR00359 B-class P450 signature 356 365 7.5E-47 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS25775 406415f1e89c42fb9753969ad6b81371 417 PRINTS PR00359 B-class P450 signature 365 376 7.5E-47 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS25775 406415f1e89c42fb9753969ad6b81371 417 PRINTS PR00359 B-class P450 signature 102 113 7.5E-47 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS25775 406415f1e89c42fb9753969ad6b81371 417 PRINTS PR00359 B-class P450 signature 152 168 7.5E-47 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS25775 406415f1e89c42fb9753969ad6b81371 417 PRINTS PR00359 B-class P450 signature 169 184 7.5E-47 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS25775 406415f1e89c42fb9753969ad6b81371 417 PRINTS PR00359 B-class P450 signature 211 233 7.5E-47 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS25775 406415f1e89c42fb9753969ad6b81371 417 PRINTS PR00359 B-class P450 signature 289 300 7.5E-47 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS02505 18ed0f125b3a515e007a15c01bed1b6d 272 ProSitePatterns PS00211 ABC transporters family signature. 153 167 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS02505 18ed0f125b3a515e007a15c01bed1b6d 272 Pfam PF00005 ABC transporter 31 181 1.3E-24 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS02505 18ed0f125b3a515e007a15c01bed1b6d 272 SMART SM00382 40 239 1.7E-12 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS02505 18ed0f125b3a515e007a15c01bed1b6d 272 SUPERFAMILY SSF52540 13 246 6.78E-47 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS02505 18ed0f125b3a515e007a15c01bed1b6d 272 Gene3D G3DSA:3.40.50.300 19 248 2.3E-48 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13940 f4d08407e7945404c450f7c281b6caa9 436 Pfam PF07690 Major Facilitator Superfamily 272 430 1.3E-12 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS13940 f4d08407e7945404c450f7c281b6caa9 436 Pfam PF07690 Major Facilitator Superfamily 34 257 1.4E-23 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS13940 f4d08407e7945404c450f7c281b6caa9 436 Gene3D G3DSA:1.20.1250.20 246 432 2.5E-17 T 09-03-2017 TK78_RS13940 f4d08407e7945404c450f7c281b6caa9 436 Gene3D G3DSA:1.20.1250.20 19 214 1.1E-26 T 09-03-2017 TK78_RS13940 f4d08407e7945404c450f7c281b6caa9 436 SUPERFAMILY SSF103473 10 427 1.7E-62 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS31390 f3a3d8058e322d4fd7daabe5111762e9 274 SUPERFAMILY SSF110710 17 271 4.97E-84 T 09-03-2017 TK78_RS31390 f3a3d8058e322d4fd7daabe5111762e9 274 Pfam PF02522 Aminoglycoside 3-N-acetyltransferase 32 266 3.9E-73 T 09-03-2017 IPR003679 Aminoglycoside N(3)-acetyltransferase GO:0046353|GO:0046677 TK78_RS10200 299c562e5fc60fc62edd93adad3e86b0 198 Gene3D G3DSA:3.40.630.30 1 196 5.7E-35 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS10200 299c562e5fc60fc62edd93adad3e86b0 198 Pfam PF00583 Acetyltransferase (GNAT) family 105 174 3.2E-8 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS10200 299c562e5fc60fc62edd93adad3e86b0 198 SUPERFAMILY SSF55729 1 194 7.27E-19 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS02785 4186c3a482d7b4029b7aa8d270ea9296 94 SUPERFAMILY SSF56349 9 90 2.35E-16 T 09-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 TK78_RS02785 4186c3a482d7b4029b7aa8d270ea9296 94 Pfam PF00589 Phage integrase family 22 90 8.8E-11 T 09-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 TK78_RS02785 4186c3a482d7b4029b7aa8d270ea9296 94 Gene3D G3DSA:1.10.443.10 8 90 4.9E-17 T 09-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 TK78_RS29780 ef9f64f8f8b13858f3dc9c12ca1a1dd0 265 Gene3D G3DSA:3.40.50.1820 21 248 2.7E-33 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS29780 ef9f64f8f8b13858f3dc9c12ca1a1dd0 265 SUPERFAMILY SSF53474 5 249 1.34E-44 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS29780 ef9f64f8f8b13858f3dc9c12ca1a1dd0 265 Pfam PF00975 Thioesterase domain 26 250 2.8E-45 T 09-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 TK78_RS29780 ef9f64f8f8b13858f3dc9c12ca1a1dd0 265 SMART SM00824 Thioesterase 28 256 3.1E-4 T 09-03-2017 IPR020802 Polyketide synthase, thioesterase domain GO:0009058|GO:0016788 TK78_RS32125 3ebdbf1fa5f27fec15e2ebdd1a7aa05c 323 Pfam PF09995 Uncharacterized protein conserved in bacteria (DUF2236) 29 257 2.0E-52 T 09-03-2017 IPR018713 Domain of unknown function DUF2236 TK78_RS32850 9b0df056900aec081b715582da3315de 519 Pfam PF11066 Protein of unknown function (DUF2867) 351 496 6.1E-41 T 09-03-2017 IPR021295 Protein of unknown function DUF2867 TK78_RS32850 9b0df056900aec081b715582da3315de 519 SUPERFAMILY SSF51735 21 280 2.84E-52 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS32850 9b0df056900aec081b715582da3315de 519 Gene3D G3DSA:3.40.50.720 20 251 1.3E-46 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS32850 9b0df056900aec081b715582da3315de 519 Pfam PF13460 NAD(P)H-binding 26 160 6.6E-22 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS26040 fde1c19958c0a4674acb3a1500cf50bb 259 PRINTS PR00737 Glycosyl hydrolase family 16 signature 220 242 4.0E-40 T 09-03-2017 IPR008264 Beta-glucanase GO:0004553|GO:0005975 TK78_RS26040 fde1c19958c0a4674acb3a1500cf50bb 259 PRINTS PR00737 Glycosyl hydrolase family 16 signature 121 137 4.0E-40 T 09-03-2017 IPR008264 Beta-glucanase GO:0004553|GO:0005975 TK78_RS26040 fde1c19958c0a4674acb3a1500cf50bb 259 PRINTS PR00737 Glycosyl hydrolase family 16 signature 142 157 4.0E-40 T 09-03-2017 IPR008264 Beta-glucanase GO:0004553|GO:0005975 TK78_RS26040 fde1c19958c0a4674acb3a1500cf50bb 259 PRINTS PR00737 Glycosyl hydrolase family 16 signature 102 120 4.0E-40 T 09-03-2017 IPR008264 Beta-glucanase GO:0004553|GO:0005975 TK78_RS26040 fde1c19958c0a4674acb3a1500cf50bb 259 PRINTS PR00737 Glycosyl hydrolase family 16 signature 245 257 4.0E-40 T 09-03-2017 IPR008264 Beta-glucanase GO:0004553|GO:0005975 TK78_RS26040 fde1c19958c0a4674acb3a1500cf50bb 259 PRINTS PR00737 Glycosyl hydrolase family 16 signature 158 171 4.0E-40 T 09-03-2017 IPR008264 Beta-glucanase GO:0004553|GO:0005975 TK78_RS26040 fde1c19958c0a4674acb3a1500cf50bb 259 Pfam PF00722 Glycosyl hydrolases family 16 65 254 2.2E-38 T 09-03-2017 IPR000757 Glycoside hydrolase family 16 GO:0004553|GO:0005975 TK78_RS26040 fde1c19958c0a4674acb3a1500cf50bb 259 ProSitePatterns PS01034 Glycosyl hydrolases family 16 active sites. 145 155 - T 09-03-2017 IPR008263 Glycoside hydrolase, family 16, active site GO:0004553|GO:0005975 TK78_RS26040 fde1c19958c0a4674acb3a1500cf50bb 259 Gene3D G3DSA:2.60.120.200 48 259 6.4E-54 T 09-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain TK78_RS26040 fde1c19958c0a4674acb3a1500cf50bb 259 SUPERFAMILY SSF49899 25 259 1.88E-53 T 09-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain TK78_RS31340 6183a7ee10e2c6272af684bcd53ec23a 176 Gene3D G3DSA:2.160.10.10 10 173 9.2E-46 T 09-03-2017 TK78_RS31340 6183a7ee10e2c6272af684bcd53ec23a 176 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 92 125 1.0E-6 T 09-03-2017 IPR001451 Hexapeptide repeat TK78_RS31340 6183a7ee10e2c6272af684bcd53ec23a 176 SUPERFAMILY SSF51161 13 172 1.8E-45 T 09-03-2017 IPR011004 Trimeric LpxA-like TK78_RS33520 9c3b8ec7e0e67fa807cfbd24829e5005 222 Gene3D G3DSA:3.40.30.10 51 220 3.8E-44 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS33520 9c3b8ec7e0e67fa807cfbd24829e5005 222 SUPERFAMILY SSF52833 48 217 9.98E-41 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS33520 9c3b8ec7e0e67fa807cfbd24829e5005 222 Pfam PF13462 Thioredoxin 61 218 3.8E-29 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS26050 277fb4d436f37c8930b9c35565b94332 300 Gene3D G3DSA:3.90.550.10 6 218 4.1E-18 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS26050 277fb4d436f37c8930b9c35565b94332 300 SUPERFAMILY SSF53448 8 230 2.09E-33 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS26050 277fb4d436f37c8930b9c35565b94332 300 Pfam PF13641 Glycosyltransferase like family 2 4 213 2.1E-9 T 09-03-2017 TK78_RS31175 6bbe26be40c66e80c0d3e049f1c7e52d 324 SUPERFAMILY SSF51197 41 306 5.04E-52 T 09-03-2017 TK78_RS31175 6bbe26be40c66e80c0d3e049f1c7e52d 324 Pfam PF02668 Taurine catabolism dioxygenase TauD, TfdA family 108 295 2.0E-17 T 09-03-2017 IPR003819 TauD/TfdA-like domain GO:0016491|GO:0055114 Reactome: R-HSA-71262 TK78_RS31175 6bbe26be40c66e80c0d3e049f1c7e52d 324 Gene3D G3DSA:3.60.130.10 17 305 1.1E-60 T 09-03-2017 TK78_RS32575 56bc615936889e06e5638db4a25927b6 169 Gene3D G3DSA:3.30.70.920 56 148 3.1E-21 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS32575 56bc615936889e06e5638db4a25927b6 169 SUPERFAMILY SSF46785 3 63 1.8E-11 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32575 56bc615936889e06e5638db4a25927b6 169 SUPERFAMILY SSF54909 64 148 8.71E-19 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS32575 56bc615936889e06e5638db4a25927b6 169 SMART SM00344 3 109 2.2E-25 T 09-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 TK78_RS32575 56bc615936889e06e5638db4a25927b6 169 Pfam PF01037 Lrp/AsnC ligand binding domain 69 138 1.1E-17 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS32575 56bc615936889e06e5638db4a25927b6 169 Pfam PF13412 Winged helix-turn-helix DNA-binding 4 50 4.1E-13 T 09-03-2017 TK78_RS32575 56bc615936889e06e5638db4a25927b6 169 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 3 19 1.9E-9 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS32575 56bc615936889e06e5638db4a25927b6 169 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 30 49 1.9E-9 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS32575 56bc615936889e06e5638db4a25927b6 169 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 19 30 1.9E-9 T 09-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 TK78_RS32575 56bc615936889e06e5638db4a25927b6 169 Gene3D G3DSA:1.10.10.10 2 52 5.5E-15 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS13720 2ca50e4b63f8d8596d0610034119eeac 350 Gene3D G3DSA:3.40.190.10 127 250 5.8E-22 T 09-03-2017 TK78_RS13720 2ca50e4b63f8d8596d0610034119eeac 350 SMART SM00062 41 275 0.0028 T 09-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF TK78_RS13720 2ca50e4b63f8d8596d0610034119eeac 350 Pfam PF09084 NMT1/THI5 like 54 264 2.1E-18 T 09-03-2017 IPR015168 SsuA/THI5-like TK78_RS13720 2ca50e4b63f8d8596d0610034119eeac 350 Gene3D G3DSA:3.40.190.10 9 96 4.7E-4 T 09-03-2017 TK78_RS13720 2ca50e4b63f8d8596d0610034119eeac 350 SUPERFAMILY SSF53850 39 264 3.35E-41 T 09-03-2017 TK78_RS05515 1a5774daa9122f2bb77290bf57f92a4c 250 SUPERFAMILY SSF53800 5 240 2.51E-47 T 09-03-2017 TK78_RS05515 1a5774daa9122f2bb77290bf57f92a4c 250 Pfam PF01903 CbiX 11 114 1.0E-26 T 09-03-2017 IPR002762 Cobalamin (vitamin B12) biosynthesis CbiX GO:0009236|GO:0016852 KEGG: 00860+4.99.1.3|MetaCyc: PWY-7377 TK78_RS05515 1a5774daa9122f2bb77290bf57f92a4c 250 Pfam PF01903 CbiX 139 233 8.6E-12 T 09-03-2017 IPR002762 Cobalamin (vitamin B12) biosynthesis CbiX GO:0009236|GO:0016852 KEGG: 00860+4.99.1.3|MetaCyc: PWY-7377 TK78_RS05515 1a5774daa9122f2bb77290bf57f92a4c 250 Gene3D G3DSA:3.40.50.1400 4 125 5.9E-31 T 09-03-2017 TK78_RS05515 1a5774daa9122f2bb77290bf57f92a4c 250 Gene3D G3DSA:3.40.50.1400 130 240 8.0E-18 T 09-03-2017 TK78_RS23655 fdeacd7fb5545af46928e1d3e5e59adf 556 Pfam PF13556 PucR C-terminal helix-turn-helix domain 497 554 5.3E-20 T 09-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain TK78_RS23655 fdeacd7fb5545af46928e1d3e5e59adf 556 Pfam PF07905 Purine catabolism regulatory protein-like family 35 145 1.5E-22 T 09-03-2017 IPR012914 Purine catabolism PurC-like domain TK78_RS31850 9eda2e206bb98d7e6f26c4e888ae864e 251 Pfam PF13613 Helix-turn-helix of DDE superfamily endonuclease 34 85 1.8E-13 T 09-03-2017 IPR027805 Transposase, Helix-turn-helix domain TK78_RS31850 9eda2e206bb98d7e6f26c4e888ae864e 251 Pfam PF13359 DDE superfamily endonuclease 102 247 7.6E-27 T 09-03-2017 IPR027806 Harbinger transposase-derived nuclease domain TK78_RS26275 acaf6ab0dbdcefa5120565280644cd28 226 Pfam PF11303 Protein of unknown function (DUF3105) 93 215 6.5E-43 T 09-03-2017 IPR021454 Protein of unknown function DUF3105 TK78_RS22695 211361ac452675b38ce39e101922f21d 155 Pfam PF00578 AhpC/TSA family 8 135 1.0E-34 T 09-03-2017 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15|Reactome: R-HSA-3299685 TK78_RS22695 211361ac452675b38ce39e101922f21d 155 SUPERFAMILY SSF52833 4 153 5.07E-47 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS22695 211361ac452675b38ce39e101922f21d 155 Gene3D G3DSA:3.40.30.10 2 153 3.0E-48 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS14055 1ddb9cb20bbbcccabd6129b7b20c23d3 262 Gene3D G3DSA:3.40.50.300 9 232 1.8E-65 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS14055 1ddb9cb20bbbcccabd6129b7b20c23d3 262 Pfam PF00005 ABC transporter 29 170 5.6E-26 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS14055 1ddb9cb20bbbcccabd6129b7b20c23d3 262 SUPERFAMILY SSF52540 10 233 7.94E-59 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS14055 1ddb9cb20bbbcccabd6129b7b20c23d3 262 SMART SM00382 36 232 4.1E-10 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS08050 21743684a2e7ba00ae1c9721f787b977 541 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 353 527 1.9E-10 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS08050 21743684a2e7ba00ae1c9721f787b977 541 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 67 242 4.6E-16 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS08050 21743684a2e7ba00ae1c9721f787b977 541 Gene3D G3DSA:1.10.3720.10 277 536 7.1E-46 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS08050 21743684a2e7ba00ae1c9721f787b977 541 Gene3D G3DSA:1.10.3720.10 3 255 1.2E-47 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS08050 21743684a2e7ba00ae1c9721f787b977 541 SUPERFAMILY SSF161098 272 535 2.22E-47 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS08050 21743684a2e7ba00ae1c9721f787b977 541 SUPERFAMILY SSF161098 3 244 2.09E-51 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS21100 9ec0ab9024ff369b76f15a274614c56a 513 PRINTS PR00175 Sodium/alanine symporter signature 343 361 2.9E-44 T 09-03-2017 IPR001463 Sodium:alanine symporter GO:0006814|GO:0015655|GO:0016020|GO:0032328 TK78_RS21100 9ec0ab9024ff369b76f15a274614c56a 513 PRINTS PR00175 Sodium/alanine symporter signature 115 137 2.9E-44 T 09-03-2017 IPR001463 Sodium:alanine symporter GO:0006814|GO:0015655|GO:0016020|GO:0032328 TK78_RS21100 9ec0ab9024ff369b76f15a274614c56a 513 PRINTS PR00175 Sodium/alanine symporter signature 393 415 2.9E-44 T 09-03-2017 IPR001463 Sodium:alanine symporter GO:0006814|GO:0015655|GO:0016020|GO:0032328 TK78_RS21100 9ec0ab9024ff369b76f15a274614c56a 513 PRINTS PR00175 Sodium/alanine symporter signature 253 272 2.9E-44 T 09-03-2017 IPR001463 Sodium:alanine symporter GO:0006814|GO:0015655|GO:0016020|GO:0032328 TK78_RS21100 9ec0ab9024ff369b76f15a274614c56a 513 PRINTS PR00175 Sodium/alanine symporter signature 454 474 2.9E-44 T 09-03-2017 IPR001463 Sodium:alanine symporter GO:0006814|GO:0015655|GO:0016020|GO:0032328 TK78_RS21100 9ec0ab9024ff369b76f15a274614c56a 513 PRINTS PR00175 Sodium/alanine symporter signature 225 243 2.9E-44 T 09-03-2017 IPR001463 Sodium:alanine symporter GO:0006814|GO:0015655|GO:0016020|GO:0032328 TK78_RS21100 9ec0ab9024ff369b76f15a274614c56a 513 Pfam PF01235 Sodium:alanine symporter family 78 489 2.7E-124 T 09-03-2017 IPR001463 Sodium:alanine symporter GO:0006814|GO:0015655|GO:0016020|GO:0032328 TK78_RS21100 9ec0ab9024ff369b76f15a274614c56a 513 TIGRFAM TIGR00835 agcS: amino acid carrier protein 43 483 1.1E-111 T 09-03-2017 IPR001463 Sodium:alanine symporter GO:0006814|GO:0015655|GO:0016020|GO:0032328 TK78_RS00225 f3e70e47d930e58cc11891a58649aa3f 304 Gene3D G3DSA:3.40.50.720 13 216 3.3E-33 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS00225 f3e70e47d930e58cc11891a58649aa3f 304 Pfam PF13460 NAD(P)H-binding 16 184 1.3E-21 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS00225 f3e70e47d930e58cc11891a58649aa3f 304 SUPERFAMILY SSF51735 13 240 3.59E-39 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31960 bd10d7165ef631baf2a057c7c5dd0f64 205 SUPERFAMILY SSF48498 83 173 1.19E-20 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS31960 bd10d7165ef631baf2a057c7c5dd0f64 205 Pfam PF00440 Bacterial regulatory proteins, tetR family 18 63 7.0E-12 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS31960 bd10d7165ef631baf2a057c7c5dd0f64 205 Pfam PF13305 WHG domain 90 168 1.7E-18 T 09-03-2017 IPR025996 WHG domain TK78_RS31960 bd10d7165ef631baf2a057c7c5dd0f64 205 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 17 30 2.6E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS31960 bd10d7165ef631baf2a057c7c5dd0f64 205 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 38 61 2.6E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS31960 bd10d7165ef631baf2a057c7c5dd0f64 205 SUPERFAMILY SSF46689 8 78 1.7E-16 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS31960 bd10d7165ef631baf2a057c7c5dd0f64 205 Gene3D G3DSA:1.10.357.10 64 185 3.9E-24 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS31960 bd10d7165ef631baf2a057c7c5dd0f64 205 Gene3D G3DSA:1.10.10.60 3 63 4.8E-20 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS05600 f76c2cf7817a37c816ce22ff48b74e81 338 Gene3D G3DSA:1.10.3720.10 104 328 1.7E-61 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS05600 f76c2cf7817a37c816ce22ff48b74e81 338 SUPERFAMILY SSF161098 100 325 7.19E-60 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS05600 f76c2cf7817a37c816ce22ff48b74e81 338 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 131 326 4.6E-24 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS11450 3a7170852fc1e0fb08751653d33a160f 228 SUPERFAMILY SSF159234 41 210 4.32E-44 T 09-03-2017 TK78_RS11450 3a7170852fc1e0fb08751653d33a160f 228 Pfam PF04167 Protein of unknown function (DUF402) 98 162 6.2E-15 T 09-03-2017 IPR007295 Domain of unknown function DUF402 TK78_RS11450 3a7170852fc1e0fb08751653d33a160f 228 Gene3D G3DSA:2.40.380.10 9 208 2.6E-73 T 09-03-2017 IPR007295 Domain of unknown function DUF402 TK78_RS01055 f751a4e9a172099913ad02be68668356 321 Pfam PF00248 Aldo/keto reductase family 15 317 2.1E-66 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS01055 f751a4e9a172099913ad02be68668356 321 SUPERFAMILY SSF51430 4 317 2.75E-86 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS01055 f751a4e9a172099913ad02be68668356 321 PRINTS PR00069 Aldo-keto reductase signature 115 133 6.4E-7 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS01055 f751a4e9a172099913ad02be68668356 321 PRINTS PR00069 Aldo-keto reductase signature 148 165 6.4E-7 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS01055 f751a4e9a172099913ad02be68668356 321 Gene3D G3DSA:3.20.20.100 5 319 1.2E-86 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS28420 785c5422b7e1de3f3d8b325508edd850 239 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 166 183 2.3E-46 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS28420 785c5422b7e1de3f3d8b325508edd850 239 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 145 164 2.3E-46 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS28420 785c5422b7e1de3f3d8b325508edd850 239 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 72 83 2.3E-46 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS28420 785c5422b7e1de3f3d8b325508edd850 239 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 119 135 2.3E-46 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS28420 785c5422b7e1de3f3d8b325508edd850 239 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 199 219 2.3E-46 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS28420 785c5422b7e1de3f3d8b325508edd850 239 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 4 21 2.3E-46 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS28420 785c5422b7e1de3f3d8b325508edd850 239 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 12 235 1.7E-65 T 09-03-2017 TK78_RS28420 785c5422b7e1de3f3d8b325508edd850 239 Gene3D G3DSA:3.40.50.720 3 235 1.0E-86 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS28420 785c5422b7e1de3f3d8b325508edd850 239 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 72 83 4.2E-12 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS28420 785c5422b7e1de3f3d8b325508edd850 239 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 145 164 4.2E-12 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS28420 785c5422b7e1de3f3d8b325508edd850 239 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 125 133 4.2E-12 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS28420 785c5422b7e1de3f3d8b325508edd850 239 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 132 160 - T 09-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TK78_RS28420 785c5422b7e1de3f3d8b325508edd850 239 SUPERFAMILY SSF51735 3 235 2.44E-84 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS28420 785c5422b7e1de3f3d8b325508edd850 239 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 3 181 1.2E-9 T 09-03-2017 TK78_RS28420 785c5422b7e1de3f3d8b325508edd850 239 TIGRFAM TIGR01830 3oxo_ACP_reduc: 3-oxoacyl-[acyl-carrier-protein] reductase 5 235 1.3E-97 T 09-03-2017 IPR011284 3-oxoacyl-(acyl-carrier-protein) reductase GO:0004316|GO:0006633|GO:0051287|GO:0055114 KEGG: 00040+1.1.1.10|KEGG: 00061+1.1.1.100|KEGG: 00780+1.1.1.100|MetaCyc: PWY-5367|MetaCyc: PWY-5515|MetaCyc: PWY-5525|MetaCyc: PWY-5971|MetaCyc: PWY-5973|MetaCyc: PWY-5989|MetaCyc: PWY-5994|MetaCyc: PWY-6113|MetaCyc: PWY-6282|MetaCyc: PWY-6519|MetaCyc: PWY-7388|MetaCyc: PWY-7663|MetaCyc: PWY-7664|MetaCyc: PWYG-321 TK78_RS09270 eb07b04c0e15e91e4a80b839338b3ec2 434 SUPERFAMILY SSF55874 295 425 2.49E-20 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09270 eb07b04c0e15e91e4a80b839338b3ec2 434 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 334 425 1.0E-9 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09270 eb07b04c0e15e91e4a80b839338b3ec2 434 SMART SM00387 330 427 1.1E-10 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09270 eb07b04c0e15e91e4a80b839338b3ec2 434 Pfam PF07730 Histidine kinase 225 292 1.1E-16 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS09270 eb07b04c0e15e91e4a80b839338b3ec2 434 Gene3D G3DSA:3.30.565.10 314 428 3.8E-12 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09270 eb07b04c0e15e91e4a80b839338b3ec2 434 PIRSF PIRSF037434 21 431 6.8E-69 T 09-03-2017 IPR017205 Signal transduction histidine kinase, ChrS TK78_RS31530 f61ec4917aa1d79045c09f9b02db634d 227 SUPERFAMILY SSF53335 39 221 1.52E-31 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS31530 f61ec4917aa1d79045c09f9b02db634d 227 Pfam PF08241 Methyltransferase domain 52 144 5.4E-17 T 09-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 TK78_RS31530 f61ec4917aa1d79045c09f9b02db634d 227 Gene3D G3DSA:3.40.50.150 15 200 8.5E-26 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS18750 22ff559147d1d7097b33fbae3cc23280 188 Pfam PF00857 Isochorismatase family 18 183 3.6E-29 T 09-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 TK78_RS18750 22ff559147d1d7097b33fbae3cc23280 188 SUPERFAMILY SSF52499 11 186 3.27E-40 T 09-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 TK78_RS18750 22ff559147d1d7097b33fbae3cc23280 188 Gene3D G3DSA:3.40.50.850 8 187 2.1E-39 T 09-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 TK78_RS07995 08ace237d8ac17f296a5367c050617f2 479 SUPERFAMILY SSF53720 4 476 4.45E-160 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS07995 08ace237d8ac17f296a5367c050617f2 479 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 250 257 - T 09-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 TK78_RS07995 08ace237d8ac17f296a5367c050617f2 479 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 278 289 - T 09-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 TK78_RS07995 08ace237d8ac17f296a5367c050617f2 479 Gene3D G3DSA:3.40.605.10 7 264 4.0E-93 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS07995 08ace237d8ac17f296a5367c050617f2 479 Pfam PF00171 Aldehyde dehydrogenase family 19 473 2.6E-163 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS07995 08ace237d8ac17f296a5367c050617f2 479 Gene3D G3DSA:3.40.309.10 265 453 2.6E-63 T 09-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 TK78_RS08150 dfd61180bf51335ff97fc2f5cf7198c3 116 PRINTS PR00061 Ribosomal protein L19 signature 88 113 6.0E-42 T 09-03-2017 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS08150 dfd61180bf51335ff97fc2f5cf7198c3 116 PRINTS PR00061 Ribosomal protein L19 signature 34 63 6.0E-42 T 09-03-2017 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS08150 dfd61180bf51335ff97fc2f5cf7198c3 116 PRINTS PR00061 Ribosomal protein L19 signature 4 33 6.0E-42 T 09-03-2017 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS08150 dfd61180bf51335ff97fc2f5cf7198c3 116 ProSitePatterns PS01015 Ribosomal protein L19 signature. 86 101 - T 09-03-2017 IPR018257 Ribosomal protein L19, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS08150 dfd61180bf51335ff97fc2f5cf7198c3 116 PIRSF PIRSF002191 2 116 2.4E-47 T 09-03-2017 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS08150 dfd61180bf51335ff97fc2f5cf7198c3 116 TIGRFAM TIGR01024 rplS_bact: ribosomal protein bL19 4 113 9.3E-47 T 09-03-2017 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS08150 dfd61180bf51335ff97fc2f5cf7198c3 116 Pfam PF01245 Ribosomal protein L19 4 113 1.3E-48 T 09-03-2017 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS08150 dfd61180bf51335ff97fc2f5cf7198c3 116 SUPERFAMILY SSF50104 3 115 1.2E-43 T 09-03-2017 IPR008991 Translation protein SH3-like domain TK78_RS08150 dfd61180bf51335ff97fc2f5cf7198c3 116 Hamap MF_00402 50S ribosomal protein L19 [rplS]. 2 114 27.949 T 09-03-2017 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS21140 4b3a83c9c01f4bac9db1322488880379 203 Gene3D G3DSA:3.30.420.10 13 185 8.7E-45 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS21140 4b3a83c9c01f4bac9db1322488880379 203 Pfam PF00929 Exonuclease 13 177 1.1E-12 T 09-03-2017 IPR013520 Exonuclease, RNase T/DNA polymerase III TK78_RS21140 4b3a83c9c01f4bac9db1322488880379 203 SUPERFAMILY SSF53098 12 184 3.79E-25 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS21140 4b3a83c9c01f4bac9db1322488880379 203 SMART SM00479 10 187 3.3E-4 T 09-03-2017 IPR013520 Exonuclease, RNase T/DNA polymerase III TK78_RS05540 4abbdea4a8b7cb613bfd2f858fa27b24 385 Gene3D G3DSA:1.10.3470.10 58 380 4.3E-84 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS05540 4abbdea4a8b7cb613bfd2f858fa27b24 385 SUPERFAMILY SSF81345 56 377 1.7E-65 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS05540 4abbdea4a8b7cb613bfd2f858fa27b24 385 Pfam PF01032 FecCD transport family 72 377 1.2E-76 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS15615 7cf13de7fd1a0172c21421327307c48c 131 Pfam PF12728 Helix-turn-helix domain 4 51 1.5E-6 T 09-03-2017 TK78_RS15615 7cf13de7fd1a0172c21421327307c48c 131 Gene3D G3DSA:2.40.50.100 65 128 3.4E-18 T 09-03-2017 TK78_RS15615 7cf13de7fd1a0172c21421327307c48c 131 SUPERFAMILY SSF50331 10 128 2.21E-15 T 09-03-2017 IPR008995 Molybdate/tungstate binding, C-terminal TK78_RS15615 7cf13de7fd1a0172c21421327307c48c 131 Gene3D G3DSA:1.10.1660.10 3 40 7.6E-5 T 09-03-2017 TK78_RS15615 7cf13de7fd1a0172c21421327307c48c 131 Pfam PF03459 TOBE domain 66 128 1.0E-12 T 09-03-2017 IPR005116 Transport-associated OB, type 1 TK78_RS32380 11cb4a93dec4ce28c98013907a540820 253 Gene3D G3DSA:3.30.450.40 87 248 3.0E-36 T 09-03-2017 IPR029016 GAF domain-like TK78_RS32380 11cb4a93dec4ce28c98013907a540820 253 Pfam PF09339 IclR helix-turn-helix domain 17 60 3.9E-8 T 09-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 TK78_RS32380 11cb4a93dec4ce28c98013907a540820 253 SUPERFAMILY SSF55781 86 248 2.81E-29 T 09-03-2017 IPR029016 GAF domain-like TK78_RS32380 11cb4a93dec4ce28c98013907a540820 253 Gene3D G3DSA:1.10.10.10 8 72 2.2E-12 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32380 11cb4a93dec4ce28c98013907a540820 253 SUPERFAMILY SSF46785 12 72 4.82E-8 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32380 11cb4a93dec4ce28c98013907a540820 253 Pfam PF01614 Bacterial transcriptional regulator 139 240 5.9E-19 T 09-03-2017 IPR014757 Transcription regulator IclR, C-terminal TK78_RS19270 1b3223c59b020fe432f14af3f6cc7997 94 Pfam PF00550 Phosphopantetheine attachment site 14 77 1.1E-11 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS19270 1b3223c59b020fe432f14af3f6cc7997 94 Gene3D G3DSA:1.10.1200.10 10 80 9.1E-16 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS19270 1b3223c59b020fe432f14af3f6cc7997 94 SMART SM00823 Phosphopantetheine attachment site 12 81 6.6E-4 T 09-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 TK78_RS19270 1b3223c59b020fe432f14af3f6cc7997 94 SUPERFAMILY SSF47336 10 85 7.46E-13 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS07720 6a9b04ed3023df25274c9b3ecfd3f9c4 421 Gene3D G3DSA:3.40.50.200 46 347 1.1E-77 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS07720 6a9b04ed3023df25274c9b3ecfd3f9c4 421 SUPERFAMILY SSF52743 55 348 1.06E-74 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS07720 6a9b04ed3023df25274c9b3ecfd3f9c4 421 TIGRFAM TIGR03921 T7SS_mycosin: type VII secretion-associated serine protease mycosin 64 415 3.6E-94 T 09-03-2017 IPR023834 Type VII secretion system peptidase S8A, mycosin-1 TK78_RS07720 6a9b04ed3023df25274c9b3ecfd3f9c4 421 Pfam PF00082 Subtilase family 73 339 6.6E-46 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS07720 6a9b04ed3023df25274c9b3ecfd3f9c4 421 PRINTS PR00723 Subtilisin serine protease family (S8) signature 289 305 5.3E-18 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS07720 6a9b04ed3023df25274c9b3ecfd3f9c4 421 PRINTS PR00723 Subtilisin serine protease family (S8) signature 73 92 5.3E-18 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS07720 6a9b04ed3023df25274c9b3ecfd3f9c4 421 PRINTS PR00723 Subtilisin serine protease family (S8) signature 127 140 5.3E-18 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS07720 6a9b04ed3023df25274c9b3ecfd3f9c4 421 ProSitePatterns PS00138 Serine proteases, subtilase family, serine active site. 290 300 - T 09-03-2017 IPR023828 Peptidase S8, subtilisin, Ser-active site TK78_RS07720 6a9b04ed3023df25274c9b3ecfd3f9c4 421 ProSitePatterns PS00137 Serine proteases, subtilase family, histidine active site. 131 141 - T 09-03-2017 IPR022398 Peptidase S8, subtilisin, His-active site TK78_RS07720 6a9b04ed3023df25274c9b3ecfd3f9c4 421 ProSitePatterns PS00136 Serine proteases, subtilase family, aspartic acid active site. 78 89 - T 09-03-2017 IPR023827 Peptidase S8, subtilisin, Asp-active site TK78_RS07825 76b76f588fa67ce6ea0f5fa9737fa602 77 SUPERFAMILY SSF64376 1 73 2.35E-19 T 09-03-2017 IPR007393 Domain of unknown function DUF448 TK78_RS07825 76b76f588fa67ce6ea0f5fa9737fa602 77 Pfam PF04296 Protein of unknown function (DUF448) 1 62 6.3E-20 T 09-03-2017 IPR007393 Domain of unknown function DUF448 TK78_RS07825 76b76f588fa67ce6ea0f5fa9737fa602 77 Gene3D G3DSA:3.30.1230.10 1 72 7.1E-21 T 09-03-2017 IPR007393 Domain of unknown function DUF448 TK78_RS14120 8024ec16192e0682238d55f692825317 367 Pfam PF00285 Citrate synthase, C-terminal domain 7 343 1.1E-85 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS14120 8024ec16192e0682238d55f692825317 367 Gene3D G3DSA:1.10.230.10 222 306 1.2E-25 T 09-03-2017 IPR016143 Citrate synthase-like, small alpha subdomain Reactome: R-HSA-163765|Reactome: R-HSA-75105 TK78_RS14120 8024ec16192e0682238d55f692825317 367 PRINTS PR00143 Citrate synthase signature 182 210 3.4E-26 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS14120 8024ec16192e0682238d55f692825317 367 PRINTS PR00143 Citrate synthase signature 294 310 3.4E-26 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS14120 8024ec16192e0682238d55f692825317 367 PRINTS PR00143 Citrate synthase signature 160 175 3.4E-26 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS14120 8024ec16192e0682238d55f692825317 367 PRINTS PR00143 Citrate synthase signature 314 328 3.4E-26 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS14120 8024ec16192e0682238d55f692825317 367 PRINTS PR00143 Citrate synthase signature 235 255 3.4E-26 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS14120 8024ec16192e0682238d55f692825317 367 ProSitePatterns PS00480 Citrate synthase signature. 242 254 - T 09-03-2017 IPR019810 Citrate synthase active site GO:0006099|GO:0046912 Reactome: R-HSA-1268020|Reactome: R-HSA-71403 TK78_RS14120 8024ec16192e0682238d55f692825317 367 SUPERFAMILY SSF48256 3 354 7.07E-96 T 09-03-2017 IPR002020 Citrate synthase GO:0046912 TK78_RS14120 8024ec16192e0682238d55f692825317 367 Gene3D G3DSA:1.10.580.10 13 221 1.4E-46 T 09-03-2017 IPR016142 Citrate synthase-like, large alpha subdomain Reactome: R-HSA-1268020|Reactome: R-HSA-71403 TK78_RS13630 84db637f751795f64dd72121cdd979d6 467 ProSitePatterns PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. 241 254 - T 09-03-2017 IPR018086 NADH:ubiquinone oxidoreductase, subunit 1, conserved site GO:0016020|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13630 84db637f751795f64dd72121cdd979d6 467 ProSitePatterns PS00667 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. 74 89 - T 09-03-2017 IPR018086 NADH:ubiquinone oxidoreductase, subunit 1, conserved site GO:0016020|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13630 84db637f751795f64dd72121cdd979d6 467 Pfam PF00146 NADH dehydrogenase 35 358 1.3E-120 T 09-03-2017 IPR001694 NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H GO:0016020|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13630 84db637f751795f64dd72121cdd979d6 467 Hamap MF_01350 NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic [ndhA]. 28 365 23.81 T 09-03-2017 IPR001694 NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H GO:0016020|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS09180 29bfe4c3f9941c4f8c2accab58ddee1f 105 Pfam PF05488 PAAR motif 7 94 1.7E-18 T 09-03-2017 IPR008727 PAAR motif TK78_RS01035 b8852ea7a152d072c78ff1f3cc191b94 419 Pfam PF01590 GAF domain 109 212 1.9E-6 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS01035 b8852ea7a152d072c78ff1f3cc191b94 419 SMART SM00862 245 311 0.0018 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS01035 b8852ea7a152d072c78ff1f3cc191b94 419 Gene3D G3DSA:1.10.10.10 240 301 6.2E-4 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS18685 b548f407340c2b9ca5210e32870725d3 151 SMART SM00345 24 83 6.2E-15 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS18685 b548f407340c2b9ca5210e32870725d3 151 Gene3D G3DSA:1.10.10.10 11 84 1.0E-24 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS18685 b548f407340c2b9ca5210e32870725d3 151 Pfam PF00392 Bacterial regulatory proteins, gntR family 20 83 2.4E-16 T 09-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 TK78_RS18685 b548f407340c2b9ca5210e32870725d3 151 SUPERFAMILY SSF46785 13 86 3.18E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32515 9f9ce0c2729cd865d920b5e44bdf1db9 191 Pfam PF02342 TerD domain 1 187 1.1E-85 T 09-03-2017 IPR003325 TerD domain GO:0006950 TK78_RS32515 9f9ce0c2729cd865d920b5e44bdf1db9 191 Gene3D G3DSA:2.60.60.30 18 184 1.3E-74 T 09-03-2017 TK78_RS31205 f44b855480526f8117964a74c667d3b4 526 PIRSF PIRSF002741 6 522 9.1E-67 T 09-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 TK78_RS31205 f44b855480526f8117964a74c667d3b4 526 Gene3D G3DSA:3.10.105.10 293 492 4.9E-43 T 09-03-2017 TK78_RS31205 f44b855480526f8117964a74c667d3b4 526 SUPERFAMILY SSF53850 33 523 1.96E-97 T 09-03-2017 TK78_RS31205 f44b855480526f8117964a74c667d3b4 526 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 77 440 8.6E-72 T 09-03-2017 IPR000914 Solute-binding protein family 5 domain TK78_RS31205 f44b855480526f8117964a74c667d3b4 526 Gene3D G3DSA:3.40.190.10 139 292 1.3E-32 T 09-03-2017 TK78_RS09745 4bf65c0140a4b73bb93c71cc787dc928 367 TIGRFAM TIGR00350 lytR_cpsA_psr: cell envelope-related function transcriptional attenuator common domain 103 261 4.7E-55 T 09-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain TK78_RS09745 4bf65c0140a4b73bb93c71cc787dc928 367 Pfam PF03816 Cell envelope-related transcriptional attenuator domain 104 261 3.2E-48 T 09-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain TK78_RS27650 6cd85a866b79ea6244140b39602f8c0e 586 Gene3D G3DSA:1.10.530.10 116 259 4.2E-10 T 09-03-2017 TK78_RS27650 6cd85a866b79ea6244140b39602f8c0e 586 SUPERFAMILY SSF49373 360 432 1.75E-6 T 09-03-2017 IPR008964 Invasin/intimin cell-adhesion fragments TK78_RS27650 6cd85a866b79ea6244140b39602f8c0e 586 Pfam PF13406 Transglycosylase SLT domain 182 224 4.0E-6 T 09-03-2017 IPR031304 Transglycosylase SLT domain 2 TK78_RS27650 6cd85a866b79ea6244140b39602f8c0e 586 SUPERFAMILY SSF53955 94 260 9.14E-36 T 09-03-2017 IPR023346 Lysozyme-like domain TK78_RS27650 6cd85a866b79ea6244140b39602f8c0e 586 Gene3D G3DSA:2.60.40.920 353 432 8.5E-5 T 09-03-2017 IPR003344 Big-1 (bacterial Ig-like domain 1) domain TK78_RS27650 6cd85a866b79ea6244140b39602f8c0e 586 PRINTS PR01217 Proline rich extensin signature 271 287 1.1E-10 T 09-03-2017 TK78_RS27650 6cd85a866b79ea6244140b39602f8c0e 586 PRINTS PR01217 Proline rich extensin signature 324 349 1.1E-10 T 09-03-2017 TK78_RS27650 6cd85a866b79ea6244140b39602f8c0e 586 PRINTS PR01217 Proline rich extensin signature 288 305 1.1E-10 T 09-03-2017 TK78_RS28175 72097451e3c350376fd10058d92e22b1 297 Gene3D G3DSA:2.60.120.620 34 274 1.4E-50 T 09-03-2017 TK78_RS28175 72097451e3c350376fd10058d92e22b1 297 Pfam PF05721 Phytanoyl-CoA dioxygenase (PhyH) 45 260 1.5E-37 T 09-03-2017 IPR008775 Phytanoyl-CoA dioxygenase TK78_RS28175 72097451e3c350376fd10058d92e22b1 297 TIGRFAM TIGR02408 ectoine_ThpD: ectoine hydroxylase 21 297 1.1E-160 T 09-03-2017 IPR012774 Ectoine dioxygenase GO:0016706|GO:0055114 TK78_RS28175 72097451e3c350376fd10058d92e22b1 297 SUPERFAMILY SSF51197 34 295 6.87E-58 T 09-03-2017 TK78_RS11785 78595373d77e230b43aedc0b0c87f877 223 Gene3D G3DSA:1.10.357.10 24 204 2.6E-34 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS11785 78595373d77e230b43aedc0b0c87f877 223 Pfam PF00440 Bacterial regulatory proteins, tetR family 39 84 6.1E-13 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS11785 78595373d77e230b43aedc0b0c87f877 223 Pfam PF13977 Bacterial transcriptional repressor 106 217 3.9E-9 T 09-03-2017 TK78_RS11785 78595373d77e230b43aedc0b0c87f877 223 SUPERFAMILY SSF46689 25 110 4.42E-18 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS11785 78595373d77e230b43aedc0b0c87f877 223 SUPERFAMILY SSF48498 105 215 5.34E-10 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS11785 78595373d77e230b43aedc0b0c87f877 223 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 59 82 9.1E-6 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS11785 78595373d77e230b43aedc0b0c87f877 223 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 38 51 9.1E-6 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS22865 ac147387cde34d5cc52f446915617082 377 Pfam PF00145 C-5 cytosine-specific DNA methylase 14 321 1.2E-54 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS22865 ac147387cde34d5cc52f446915617082 377 TIGRFAM TIGR00675 dcm: DNA (cytosine-5-)-methyltransferase 17 213 5.3E-34 T 09-03-2017 IPR001525 C-5 cytosine methyltransferase GO:0008168 KEGG: 00270+2.1.1.37 TK78_RS22865 ac147387cde34d5cc52f446915617082 377 PRINTS PR00105 Cytosine-specific DNA methyltransferase signature 165 178 3.9E-10 T 09-03-2017 IPR001525 C-5 cytosine methyltransferase GO:0008168 KEGG: 00270+2.1.1.37 TK78_RS22865 ac147387cde34d5cc52f446915617082 377 PRINTS PR00105 Cytosine-specific DNA methyltransferase signature 119 133 3.9E-10 T 09-03-2017 IPR001525 C-5 cytosine methyltransferase GO:0008168 KEGG: 00270+2.1.1.37 TK78_RS22865 ac147387cde34d5cc52f446915617082 377 PRINTS PR00105 Cytosine-specific DNA methyltransferase signature 15 31 3.9E-10 T 09-03-2017 IPR001525 C-5 cytosine methyltransferase GO:0008168 KEGG: 00270+2.1.1.37 TK78_RS22865 ac147387cde34d5cc52f446915617082 377 ProSitePatterns PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 303 321 - T 09-03-2017 IPR031303 DNA methylase, C-5 cytosine-specific, conserved site KEGG: 00270+2.1.1.37 TK78_RS22865 ac147387cde34d5cc52f446915617082 377 Gene3D G3DSA:3.40.50.150 13 209 3.4E-49 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS22865 ac147387cde34d5cc52f446915617082 377 Gene3D G3DSA:3.90.120.10 276 308 1.8E-5 T 09-03-2017 TK78_RS22865 ac147387cde34d5cc52f446915617082 377 SUPERFAMILY SSF53335 274 321 4.31E-69 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS22865 ac147387cde34d5cc52f446915617082 377 SUPERFAMILY SSF53335 14 247 4.31E-69 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS29630 ee36b9346ae5be088afa7ffb250e5eaa 33 SUPERFAMILY SSF48179 3 33 8.5E-9 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS29630 ee36b9346ae5be088afa7ffb250e5eaa 33 Gene3D G3DSA:1.10.1040.10 2 33 6.4E-7 T 09-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 TK78_RS29630 ee36b9346ae5be088afa7ffb250e5eaa 33 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 2 33 4.0E-8 T 09-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 TK78_RS27005 af58896b87a5da2f26516b77e0a777e0 205 Pfam PF13548 Domain of unknown function (DUF4126) 6 172 2.0E-46 T 09-03-2017 IPR025196 Domain of unknown function DUF4126 TK78_RS33445 4589b8ea20b06e6a1cd30286c6c022ab 266 Pfam PF01061 ABC-2 type transporter 13 217 1.5E-31 T 09-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 TK78_RS33445 4589b8ea20b06e6a1cd30286c6c022ab 266 PIRSF PIRSF006648 1 265 2.2E-65 T 09-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 TK78_RS27630 7ff1e10e08176c2a8dfbb13a1a8582e0 156 Pfam PF03061 Thioesterase superfamily 62 139 1.8E-16 T 09-03-2017 IPR006683 Thioesterase domain Reactome: R-HSA-75105 TK78_RS27630 7ff1e10e08176c2a8dfbb13a1a8582e0 156 SUPERFAMILY SSF54637 29 151 1.5E-28 T 09-03-2017 IPR029069 HotDog domain TK78_RS27630 7ff1e10e08176c2a8dfbb13a1a8582e0 156 Gene3D G3DSA:3.10.129.10 23 149 8.6E-47 T 09-03-2017 IPR029069 HotDog domain TK78_RS27630 7ff1e10e08176c2a8dfbb13a1a8582e0 156 TIGRFAM TIGR00369 unchar_dom_1: uncharacterized domain 1 35 146 4.5E-28 T 09-03-2017 IPR003736 Phenylacetic acid degradation-related domain Reactome: R-HSA-75105 TK78_RS14880 de319d97997801af5b123ae5245680e9 304 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 120 290 2.6E-18 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS14880 de319d97997801af5b123ae5245680e9 304 SUPERFAMILY SSF161098 36 304 4.67E-64 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS14880 de319d97997801af5b123ae5245680e9 304 Gene3D G3DSA:1.10.3720.10 35 289 1.9E-57 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS18955 bb9eb160558c015fb4f36b1c75a99aef 112 Pfam PF10724 Protein of unknown function (DUF2516) 6 91 1.5E-28 T 09-03-2017 IPR019662 Protein of unknown function DUF2516 TK78_RS07740 f7297c604e6a1e3622a2df776edd5151 77 Pfam PF04149 Domain of unknown function (DUF397) 28 70 4.3E-8 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS28125 72a93d61a59707eb3ea35903e2857546 159 SUPERFAMILY SSF55729 4 154 3.92E-28 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS28125 72a93d61a59707eb3ea35903e2857546 159 Pfam PF13302 Acetyltransferase (GNAT) domain 5 134 2.0E-23 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS28125 72a93d61a59707eb3ea35903e2857546 159 Gene3D G3DSA:3.40.630.30 3 155 2.3E-29 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS12440 e8d7dfc6ee050b22bb61b8bd8add5dee 395 SUPERFAMILY SSF52440 176 291 8.63E-34 T 09-03-2017 IPR016185 Pre-ATP-grasp domain TK78_RS12440 e8d7dfc6ee050b22bb61b8bd8add5dee 395 SUPERFAMILY SSF56059 3 169 1.02E-70 T 09-03-2017 TK78_RS12440 e8d7dfc6ee050b22bb61b8bd8add5dee 395 SUPERFAMILY SSF56059 278 393 1.02E-70 T 09-03-2017 TK78_RS12440 e8d7dfc6ee050b22bb61b8bd8add5dee 395 Pfam PF03738 Glutathionylspermidine synthase preATP-grasp 12 394 1.9E-134 T 09-03-2017 IPR005494 Glutathionylspermidine synthase, pre-ATP-grasp-like domain TK78_RS14155 7f6d99b627499c21c17e5b575f804066 367 Pfam PF01135 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) 13 240 4.0E-25 T 09-03-2017 TK78_RS14155 7f6d99b627499c21c17e5b575f804066 367 Gene3D G3DSA:3.40.50.150 18 244 5.0E-49 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS14155 7f6d99b627499c21c17e5b575f804066 367 SUPERFAMILY SSF53335 12 203 1.74E-26 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS14140 8c1c7c31c2014a190a8e367837085832 242 Pfam PF00485 Phosphoribulokinase / Uridine kinase family 49 206 2.8E-6 T 09-03-2017 IPR006083 Phosphoribulokinase/uridine kinase GO:0005524|GO:0008152|GO:0016301 TK78_RS14140 8c1c7c31c2014a190a8e367837085832 242 Gene3D G3DSA:3.40.50.300 33 232 2.4E-28 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS14140 8c1c7c31c2014a190a8e367837085832 242 SUPERFAMILY SSF52540 43 230 1.73E-15 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29070 1dbd22d4da351524c46d75c6b3a3606d 424 Pfam PF07075 Protein of unknown function (DUF1343) 63 422 9.4E-131 T 09-03-2017 IPR008302 Uncharacterised conserved protein UCP016719 TK78_RS29070 1dbd22d4da351524c46d75c6b3a3606d 424 PIRSF PIRSF016719 20 423 2.2E-152 T 09-03-2017 IPR008302 Uncharacterised conserved protein UCP016719 TK78_RS19445 e2bf6635bb69deb039806d4a57ed0fba 336 SUPERFAMILY SSF49785 220 327 7.14E-11 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS19445 e2bf6635bb69deb039806d4a57ed0fba 336 Gene3D G3DSA:2.60.120.260 201 328 5.8E-12 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS25225 dfb1fbe0fb28ff8f8ec09935b22966c9 245 Gene3D G3DSA:3.40.50.620 72 192 1.5E-9 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS25225 dfb1fbe0fb28ff8f8ec09935b22966c9 245 Pfam PF02698 DUF218 domain 74 192 1.1E-23 T 09-03-2017 IPR003848 Domain of unknown function DUF218 TK78_RS22565 a56f798e6e4e6f80d831b61c75e23b59 784 Pfam PF05547 Immune inhibitor A peptidase M6 83 776 1.7E-225 T 09-03-2017 IPR008757 Peptidase M6-like, domain GO:0006508|GO:0008233 TK78_RS22565 a56f798e6e4e6f80d831b61c75e23b59 784 TIGRFAM TIGR03296 M6dom_TIGR03296: M6 family metalloprotease domain 152 458 1.4E-87 T 09-03-2017 IPR008757 Peptidase M6-like, domain GO:0006508|GO:0008233 TK78_RS22565 a56f798e6e4e6f80d831b61c75e23b59 784 Gene3D G3DSA:3.40.390.10 327 406 2.1E-27 T 09-03-2017 IPR024079 Metallopeptidase, catalytic domain GO:0008237 TK78_RS22565 a56f798e6e4e6f80d831b61c75e23b59 784 Gene3D G3DSA:3.40.390.10 213 264 2.1E-27 T 09-03-2017 IPR024079 Metallopeptidase, catalytic domain GO:0008237 TK78_RS22565 a56f798e6e4e6f80d831b61c75e23b59 784 SUPERFAMILY SSF55486 213 273 3.54E-15 T 09-03-2017 TK78_RS22565 a56f798e6e4e6f80d831b61c75e23b59 784 SUPERFAMILY SSF55486 327 406 3.54E-15 T 09-03-2017 TK78_RS22565 a56f798e6e4e6f80d831b61c75e23b59 784 PIRSF PIRSF007519 1 782 3.4E-215 T 09-03-2017 IPR012300 Peptidase M6, InhA TK78_RS19395 2603145d2496497a029c5d38e5ca1d44 443 PIRSF PIRSF037434 29 443 2.0E-135 T 09-03-2017 IPR017205 Signal transduction histidine kinase, ChrS TK78_RS19395 2603145d2496497a029c5d38e5ca1d44 443 Gene3D G3DSA:3.30.565.10 341 441 2.4E-9 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS19395 2603145d2496497a029c5d38e5ca1d44 443 Pfam PF07730 Histidine kinase 230 297 7.5E-17 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS19395 2603145d2496497a029c5d38e5ca1d44 443 PRINTS PR00344 Bacterial sensor protein C-terminal signature 375 389 3.4E-5 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS19395 2603145d2496497a029c5d38e5ca1d44 443 PRINTS PR00344 Bacterial sensor protein C-terminal signature 398 416 3.4E-5 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS19395 2603145d2496497a029c5d38e5ca1d44 443 PRINTS PR00344 Bacterial sensor protein C-terminal signature 422 435 3.4E-5 T 09-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TK78_RS19395 2603145d2496497a029c5d38e5ca1d44 443 SUPERFAMILY SSF55874 323 435 6.85E-16 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS19395 2603145d2496497a029c5d38e5ca1d44 443 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 343 437 1.0E-5 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS34200 5efcad0e3af1c2065dfed860ad3dec55 217 Pfam PF06912 Protein of unknown function (DUF1275) 1 187 3.1E-21 T 09-03-2017 IPR010699 Protein of unknown function DUF1275 TK78_RS09460 f35fbc41629bdece19faf5ad55c11de2 471 SUPERFAMILY SSF103473 66 452 8.5E-36 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS09460 f35fbc41629bdece19faf5ad55c11de2 471 Gene3D G3DSA:1.20.1250.20 66 247 4.4E-10 T 09-03-2017 TK78_RS09460 f35fbc41629bdece19faf5ad55c11de2 471 Gene3D G3DSA:1.20.1250.20 272 450 2.9E-13 T 09-03-2017 TK78_RS09460 f35fbc41629bdece19faf5ad55c11de2 471 Pfam PF07690 Major Facilitator Superfamily 298 453 8.9E-10 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS09460 f35fbc41629bdece19faf5ad55c11de2 471 Pfam PF07690 Major Facilitator Superfamily 70 288 7.8E-11 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS19745 d596e8ee807ef2c66405eef92bedde50 316 Pfam PF10728 Domain of unknown function (DUF2520) 152 277 5.0E-38 T 09-03-2017 IPR018931 Domain of unknown function DUF2520 TK78_RS19745 d596e8ee807ef2c66405eef92bedde50 316 SUPERFAMILY SSF48179 185 284 8.84E-24 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS19745 d596e8ee807ef2c66405eef92bedde50 316 Gene3D G3DSA:3.40.50.720 19 182 2.1E-34 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS19745 d596e8ee807ef2c66405eef92bedde50 316 Gene3D G3DSA:1.10.1040.20 185 282 7.3E-31 T 09-03-2017 IPR018931 Domain of unknown function DUF2520 TK78_RS19745 d596e8ee807ef2c66405eef92bedde50 316 Pfam PF10727 Rossmann-like domain 13 135 2.6E-42 T 09-03-2017 IPR019665 Putative oxidoreductase/dehydrogenase, Rossmann-like domain TK78_RS19745 d596e8ee807ef2c66405eef92bedde50 316 SUPERFAMILY SSF51735 21 183 4.31E-26 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS33560 a783789618eb8bb77136fe582c6edbc4 121 Gene3D G3DSA:3.20.20.30 22 119 1.7E-30 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS33560 a783789618eb8bb77136fe582c6edbc4 121 Pfam PF00296 Luciferase-like monooxygenase 19 119 1.1E-26 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS33560 a783789618eb8bb77136fe582c6edbc4 121 SUPERFAMILY SSF51679 24 119 4.37E-30 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS29375 66cc9aac535953df2808ca006c3ccd4e 419 Pfam PF07690 Major Facilitator Superfamily 42 263 1.8E-12 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS29375 66cc9aac535953df2808ca006c3ccd4e 419 Gene3D G3DSA:1.20.1250.20 33 199 9.0E-13 T 09-03-2017 TK78_RS29375 66cc9aac535953df2808ca006c3ccd4e 419 Gene3D G3DSA:1.20.1250.20 211 384 1.2E-10 T 09-03-2017 TK78_RS29375 66cc9aac535953df2808ca006c3ccd4e 419 SUPERFAMILY SSF103473 13 386 3.66E-33 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS08760 1bf9d00a0ea9221c2123d0932dce2bf2 846 Pfam PF15648 Restriction endonuclease fold toxin 5 719 809 9.6E-24 T 09-03-2017 IPR028904 Tox-REase-5 domain TK78_RS32870 70387653d7621aa926d9e4e0778c2639 810 SUPERFAMILY SSF53474 606 704 2.34E-12 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS32870 70387653d7621aa926d9e4e0778c2639 810 Gene3D G3DSA:3.40.50.1820 450 454 1.9E-6 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS32870 70387653d7621aa926d9e4e0778c2639 810 Gene3D G3DSA:3.40.50.1820 624 711 1.9E-6 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS16975 e00717fef73072203fb5ecd230c2b9b7 219 Pfam PF02630 SCO1/SenC 55 162 9.4E-24 T 09-03-2017 IPR003782 Copper chaperone SCO1/SenC Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS16975 e00717fef73072203fb5ecd230c2b9b7 219 Gene3D G3DSA:3.40.30.10 12 216 1.1E-42 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS16975 e00717fef73072203fb5ecd230c2b9b7 219 SUPERFAMILY SSF52833 55 215 3.58E-35 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS08460 c3c2ac4a9c6dbfff59b34fd274dee64d 214 Pfam PF05331 Protein of unknown function (DUF742) 102 214 6.5E-40 T 09-03-2017 IPR007995 Protein of unknown function DUF742 TK78_RS23990 44ee2b734b52a706263aeb8aebe7328a 536 Gene3D G3DSA:3.40.50.410 171 348 1.6E-27 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS23990 44ee2b734b52a706263aeb8aebe7328a 536 Pfam PF00092 von Willebrand factor type A domain 177 346 1.7E-21 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS23990 44ee2b734b52a706263aeb8aebe7328a 536 Pfam PF12034 Domain of unknown function (DUF3520) 358 438 1.9E-24 T 09-03-2017 IPR021908 Protein of unknown function DUF3520 TK78_RS23990 44ee2b734b52a706263aeb8aebe7328a 536 SUPERFAMILY SSF53300 171 347 1.01E-32 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS23990 44ee2b734b52a706263aeb8aebe7328a 536 ProSitePatterns PS00362 Ribosomal protein S15 signature. 351 381 - T 09-03-2017 IPR000589 Ribosomal protein S15 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TK78_RS23990 44ee2b734b52a706263aeb8aebe7328a 536 Pfam PF12450 von Willebrand factor 79 139 3.4E-16 T 09-03-2017 IPR022156 Uncharacterised protein YfbK, N-terminal TK78_RS23990 44ee2b734b52a706263aeb8aebe7328a 536 SMART SM00327 174 351 6.2E-26 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS07325 9fac00002042e6c3d61c836860b7190f 201 Pfam PF16291 Domain of unknown function (DUF4937 2 86 1.2E-28 T 09-03-2017 IPR032555 Domain of unknown function DUF4937 TK78_RS11690 360aaf441360e36dd8f1d41335d0556c 445 Gene3D G3DSA:3.20.20.10 161 284 2.3E-11 T 09-03-2017 IPR029066 PLP-binding barrel TK78_RS11690 360aaf441360e36dd8f1d41335d0556c 445 Pfam PF01168 Alanine racemase, N-terminal domain 74 280 3.3E-10 T 09-03-2017 IPR001608 Alanine racemase, N-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TK78_RS11690 360aaf441360e36dd8f1d41335d0556c 445 SUPERFAMILY SSF51419 75 289 2.49E-21 T 09-03-2017 IPR029066 PLP-binding barrel TK78_RS11690 360aaf441360e36dd8f1d41335d0556c 445 Pfam PF14031 Putative serine dehydratase domain 334 429 1.1E-14 T 09-03-2017 IPR026956 D-serine dehydratase-like domain TK78_RS11690 360aaf441360e36dd8f1d41335d0556c 445 SMART SM01119 334 432 1.2E-31 T 09-03-2017 IPR026956 D-serine dehydratase-like domain TK78_RS06475 1a4fc07b24228e0fb9c1a198f70f0739 295 Gene3D G3DSA:3.40.50.10490 5 148 5.3E-13 T 09-03-2017 TK78_RS06475 1a4fc07b24228e0fb9c1a198f70f0739 295 SUPERFAMILY SSF53697 25 290 8.77E-40 T 09-03-2017 TK78_RS06475 1a4fc07b24228e0fb9c1a198f70f0739 295 Gene3D G3DSA:3.40.50.10490 162 251 2.5E-21 T 09-03-2017 TK78_RS06475 1a4fc07b24228e0fb9c1a198f70f0739 295 Gene3D G3DSA:3.40.50.10490 252 290 6.2E-7 T 09-03-2017 TK78_RS17170 0dcef9897bf963f4bf0761a30faa721d 152 Gene3D G3DSA:1.10.10.10 5 148 2.0E-27 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS17170 0dcef9897bf963f4bf0761a30faa721d 152 SUPERFAMILY SSF46785 10 148 3.31E-22 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS17170 0dcef9897bf963f4bf0761a30faa721d 152 SMART SM00347 32 137 9.1E-11 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS17170 0dcef9897bf963f4bf0761a30faa721d 152 PRINTS PR00598 Bacterial regulatory protein MarR family signature 97 113 7.1E-6 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS17170 0dcef9897bf963f4bf0761a30faa721d 152 PRINTS PR00598 Bacterial regulatory protein MarR family signature 78 93 7.1E-6 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS17170 0dcef9897bf963f4bf0761a30faa721d 152 PRINTS PR00598 Bacterial regulatory protein MarR family signature 61 77 7.1E-6 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS17170 0dcef9897bf963f4bf0761a30faa721d 152 Pfam PF01047 MarR family 40 101 8.2E-9 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS11470 e8a85f1643d1aaf8eab22d037bbfdc60 98 Gene3D G3DSA:1.10.1220.10 19 62 2.0E-6 T 09-03-2017 IPR013321 Arc-type ribbon-helix-helix GO:0006355 TK78_RS11470 e8a85f1643d1aaf8eab22d037bbfdc60 98 SUPERFAMILY SSF47598 18 72 5.56E-10 T 09-03-2017 IPR010985 Ribbon-helix-helix GO:0006355 TK78_RS01800 946fb434c211e50cd34278a03c708fa4 679 TIGRFAM TIGR02632 RhaD_aldol-ADH: rhamnulose-1-phosphate aldolase/alcohol dehydrogenase 8 679 0.0 T 09-03-2017 IPR013454 Bifunctional rhamnulose-1-phosphate aldolase/alcohol dehydrogenase TK78_RS01800 946fb434c211e50cd34278a03c708fa4 679 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 427 673 1.9E-45 T 09-03-2017 TK78_RS01800 946fb434c211e50cd34278a03c708fa4 679 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 543 559 2.6E-22 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS01800 946fb434c211e50cd34278a03c708fa4 679 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 422 439 2.6E-22 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS01800 946fb434c211e50cd34278a03c708fa4 679 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 495 506 2.6E-22 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS01800 946fb434c211e50cd34278a03c708fa4 679 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 637 657 2.6E-22 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS01800 946fb434c211e50cd34278a03c708fa4 679 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 590 607 2.6E-22 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS01800 946fb434c211e50cd34278a03c708fa4 679 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 569 588 2.6E-22 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS01800 946fb434c211e50cd34278a03c708fa4 679 SUPERFAMILY SSF53639 10 212 1.43E-29 T 09-03-2017 IPR001303 Class II aldolase/adducin N-terminal TK78_RS01800 946fb434c211e50cd34278a03c708fa4 679 Gene3D G3DSA:3.40.50.720 400 674 1.7E-62 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS01800 946fb434c211e50cd34278a03c708fa4 679 SUPERFAMILY SSF51735 409 676 1.66E-60 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS01800 946fb434c211e50cd34278a03c708fa4 679 Pfam PF00596 Class II Aldolase and Adducin N-terminal domain 11 210 2.9E-23 T 09-03-2017 IPR001303 Class II aldolase/adducin N-terminal TK78_RS01800 946fb434c211e50cd34278a03c708fa4 679 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 495 506 6.4E-5 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS01800 946fb434c211e50cd34278a03c708fa4 679 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 569 588 6.4E-5 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS01800 946fb434c211e50cd34278a03c708fa4 679 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 549 557 6.4E-5 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS01800 946fb434c211e50cd34278a03c708fa4 679 SMART SM01007 9 211 2.0E-33 T 09-03-2017 IPR001303 Class II aldolase/adducin N-terminal TK78_RS01800 946fb434c211e50cd34278a03c708fa4 679 Gene3D G3DSA:3.40.225.10 6 212 1.7E-31 T 09-03-2017 IPR001303 Class II aldolase/adducin N-terminal TK78_RS16750 b783b9e7b8f54131ada9a13c41685dc0 191 Pfam PF00720 Subtilisin inhibitor-like 83 166 4.3E-9 T 09-03-2017 IPR023549 Subtilisin inhibitor GO:0004867 TK78_RS16750 b783b9e7b8f54131ada9a13c41685dc0 191 SUPERFAMILY SSF55399 97 187 5.36E-19 T 09-03-2017 IPR023549 Subtilisin inhibitor GO:0004867 TK78_RS16750 b783b9e7b8f54131ada9a13c41685dc0 191 ProDom PD004028 INHIBITOR PROTEASE SERINE DIRECT SEQUENCING SUBTILISIN PRECURSOR SIGNAL INHIBITOR-LIKE INHIBITOR 100 178 9.0E-5 T 09-03-2017 IPR023549 Subtilisin inhibitor GO:0004867 TK78_RS16750 b783b9e7b8f54131ada9a13c41685dc0 191 Gene3D G3DSA:3.30.350.10 80 187 7.5E-29 T 09-03-2017 IPR023549 Subtilisin inhibitor GO:0004867 TK78_RS16750 b783b9e7b8f54131ada9a13c41685dc0 191 ProSitePatterns PS00999 Streptomyces subtilisin-type inhibitors signature. 104 121 - T 09-03-2017 IPR020054 Proteinase inhibitor I16, Streptomyces subtilisin-type inhibitor, conserved site GO:0004867 TK78_RS16255 e674d15731fe64a9283c87d4a9c8b57d 586 SUPERFAMILY SSF49785 367 514 6.8E-11 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS16255 e674d15731fe64a9283c87d4a9c8b57d 586 SUPERFAMILY SSF53474 68 398 1.04E-41 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS16255 e674d15731fe64a9283c87d4a9c8b57d 586 TIGRFAM TIGR00976 /NonD: hydrolase CocE/NonD family protein 86 427 2.1E-86 T 09-03-2017 IPR005674 CocE/Serine esterase GO:0016787 TK78_RS16255 e674d15731fe64a9283c87d4a9c8b57d 586 TIGRFAM TIGR00976 /NonD: hydrolase CocE/NonD family protein 427 568 8.1E-21 T 09-03-2017 IPR005674 CocE/Serine esterase GO:0016787 TK78_RS16255 e674d15731fe64a9283c87d4a9c8b57d 586 Gene3D G3DSA:2.60.120.260 390 512 3.4E-8 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS16255 e674d15731fe64a9283c87d4a9c8b57d 586 Gene3D G3DSA:3.40.50.1820 55 233 2.5E-53 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS16255 e674d15731fe64a9283c87d4a9c8b57d 586 Gene3D G3DSA:3.40.50.1820 299 389 2.5E-53 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS16255 e674d15731fe64a9283c87d4a9c8b57d 586 Pfam PF02129 X-Pro dipeptidyl-peptidase (S15 family) 82 349 6.0E-49 T 09-03-2017 IPR000383 Xaa-Pro dipeptidyl-peptidase-like domain GO:0016787 TK78_RS16255 e674d15731fe64a9283c87d4a9c8b57d 586 SMART SM00939 372 547 8.3E-7 T 09-03-2017 IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal GO:0008239 TK78_RS13380 960294e63fb68213226610a9266feca3 543 Hamap MF_00445 NAD(P)H-quinone oxidoreductase subunit 2, chloroplastic [ndhB]. 43 535 15.141 T 09-03-2017 IPR010096 NAD(P)H-quinone oxidoreductase, subunit N/subunit 2 GO:0008137|GO:0042773|GO:0055114 TK78_RS13380 960294e63fb68213226610a9266feca3 543 Pfam PF00361 Proton-conducting membrane transporter 166 469 5.8E-54 T 09-03-2017 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS22360 6c7877cd9e5671ed415ecfe7c5c34f96 159 Pfam PF09391 Protein of unknown function (DUF2000) 28 158 4.2E-45 T 09-03-2017 IPR018988 Protein of unknown function DUF2000 TK78_RS22360 6c7877cd9e5671ed415ecfe7c5c34f96 159 SUPERFAMILY SSF102462 25 159 7.85E-46 T 09-03-2017 IPR023476 Peptidyl-tRNA hydrolase II domain MetaCyc: PWY-6308 TK78_RS22360 6c7877cd9e5671ed415ecfe7c5c34f96 159 Gene3D G3DSA:3.40.1490.10 25 159 2.2E-64 T 09-03-2017 IPR023476 Peptidyl-tRNA hydrolase II domain MetaCyc: PWY-6308 TK78_RS26370 6d867987eeeed7d3513a753ac66f6f5d 292 Gene3D G3DSA:1.10.3720.10 21 279 1.5E-67 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS26370 6d867987eeeed7d3513a753ac66f6f5d 292 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 98 285 5.4E-20 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS26370 6d867987eeeed7d3513a753ac66f6f5d 292 SUPERFAMILY SSF161098 22 292 3.53E-70 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS02725 0eb202177184dc2fbbdd31a0cbbd09f1 169 SUPERFAMILY SSF55811 18 142 3.66E-27 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS02725 0eb202177184dc2fbbdd31a0cbbd09f1 169 Pfam PF00293 NUDIX domain 22 140 7.6E-20 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS02725 0eb202177184dc2fbbdd31a0cbbd09f1 169 Gene3D G3DSA:3.90.79.10 22 138 3.0E-25 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS25130 c67b5493a20edb9e5b52cb1f7b3cd4db 392 Pfam PF13343 Bacterial extracellular solute-binding protein 128 349 5.7E-38 T 09-03-2017 TK78_RS25130 c67b5493a20edb9e5b52cb1f7b3cd4db 392 Gene3D G3DSA:3.40.190.10 318 359 1.8E-26 T 09-03-2017 TK78_RS25130 c67b5493a20edb9e5b52cb1f7b3cd4db 392 Gene3D G3DSA:3.40.190.10 18 172 1.8E-26 T 09-03-2017 TK78_RS25130 c67b5493a20edb9e5b52cb1f7b3cd4db 392 SUPERFAMILY SSF53850 71 389 1.7E-48 T 09-03-2017 TK78_RS25130 c67b5493a20edb9e5b52cb1f7b3cd4db 392 Gene3D G3DSA:3.40.190.10 175 317 2.2E-24 T 09-03-2017 TK78_RS01555 6750a0a3bbcb2c370c9e001412f7408d 244 Gene3D G3DSA:3.40.50.10320 13 242 5.0E-49 T 09-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 TK78_RS01555 6750a0a3bbcb2c370c9e001412f7408d 244 Pfam PF02585 GlcNAc-PI de-N-acetylase 17 145 5.0E-26 T 09-03-2017 IPR003737 N-acetylglucosaminyl phosphatidylinositol deacetylase-related Reactome: R-HSA-162710 TK78_RS01555 6750a0a3bbcb2c370c9e001412f7408d 244 SUPERFAMILY SSF102588 13 204 6.67E-44 T 09-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 TK78_RS28930 92cef244f62286ff4091dbba75784a11 169 Gene3D G3DSA:2.40.380.10 15 163 1.7E-38 T 09-03-2017 IPR007295 Domain of unknown function DUF402 TK78_RS28930 92cef244f62286ff4091dbba75784a11 169 SUPERFAMILY SSF159234 32 140 1.57E-14 T 09-03-2017 TK78_RS28930 92cef244f62286ff4091dbba75784a11 169 Pfam PF04167 Protein of unknown function (DUF402) 65 132 1.7E-19 T 09-03-2017 IPR007295 Domain of unknown function DUF402 TK78_RS02670 4922b1ae24b2f69828adfeee8c408060 695 SUPERFAMILY SSF82866 129 336 1.05E-32 T 09-03-2017 TK78_RS02670 4922b1ae24b2f69828adfeee8c408060 695 Gene3D G3DSA:1.20.1640.10 136 341 3.1E-29 T 09-03-2017 TK78_RS02670 4922b1ae24b2f69828adfeee8c408060 695 Gene3D G3DSA:1.20.1640.10 480 688 2.3E-25 T 09-03-2017 TK78_RS02670 4922b1ae24b2f69828adfeee8c408060 695 Pfam PF03176 MMPL family 45 367 4.6E-66 T 09-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 TK78_RS02670 4922b1ae24b2f69828adfeee8c408060 695 Pfam PF03176 MMPL family 399 687 4.3E-52 T 09-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 TK78_RS02670 4922b1ae24b2f69828adfeee8c408060 695 SUPERFAMILY SSF82866 472 687 5.1E-32 T 09-03-2017 TK78_RS32980 47e93dba215aaa03aa3e26630ae419f0 606 Gene3D G3DSA:3.30.379.10 24 66 5.2E-7 T 09-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS32980 47e93dba215aaa03aa3e26630ae419f0 606 SUPERFAMILY SSF51445 86 307 1.05E-45 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS32980 47e93dba215aaa03aa3e26630ae419f0 606 SUPERFAMILY SSF51445 336 428 1.05E-45 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS32980 47e93dba215aaa03aa3e26630ae419f0 606 PRINTS PR00738 Glycosyl hydrolase family 20 signature 47 67 3.4E-7 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS32980 47e93dba215aaa03aa3e26630ae419f0 606 PRINTS PR00738 Glycosyl hydrolase family 20 signature 80 97 3.4E-7 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS32980 47e93dba215aaa03aa3e26630ae419f0 606 PRINTS PR00738 Glycosyl hydrolase family 20 signature 155 172 3.4E-7 T 09-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS32980 47e93dba215aaa03aa3e26630ae419f0 606 SUPERFAMILY SSF55545 7 84 2.27E-8 T 09-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 TK78_RS32980 47e93dba215aaa03aa3e26630ae419f0 606 Pfam PF02838 Glycosyl hydrolase family 20, domain 2 24 82 4.1E-6 T 09-03-2017 IPR015882 Beta-hexosaminidase, bacteial type, N-terminal KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 TK78_RS32980 47e93dba215aaa03aa3e26630ae419f0 606 Gene3D G3DSA:3.20.20.80 67 308 1.4E-27 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS16405 75b724ebd4769aab2d8a3fe31c2f68a5 527 Pfam PF00270 DEAD/DEAH box helicase 107 274 9.7E-44 T 09-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 TK78_RS16405 75b724ebd4769aab2d8a3fe31c2f68a5 527 SMART SM00487 102 302 1.3E-49 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS16405 75b724ebd4769aab2d8a3fe31c2f68a5 527 Pfam PF00271 Helicase conserved C-terminal domain 315 417 2.1E-24 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS16405 75b724ebd4769aab2d8a3fe31c2f68a5 527 SMART SM00490 336 417 3.0E-29 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS16405 75b724ebd4769aab2d8a3fe31c2f68a5 527 Gene3D G3DSA:3.40.50.300 292 444 1.2E-41 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS16405 75b724ebd4769aab2d8a3fe31c2f68a5 527 Gene3D G3DSA:3.40.50.300 80 291 2.3E-67 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS16405 75b724ebd4769aab2d8a3fe31c2f68a5 527 SUPERFAMILY SSF52540 154 436 1.45E-65 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23350 4225004bf2095c053b5c8b4608d6732c 244 Pfam PF09859 Oxygenase, catalysing oxidative methylation of damaged DNA 72 243 5.3E-79 T 09-03-2017 IPR018655 Protein of unknown function DUF2086 TK78_RS12230 e4339e9f9c09fa14da39e3f77d0a8687 364 Pfam PF01757 Acyltransferase family 30 348 2.5E-27 T 09-03-2017 IPR002656 Acyltransferase 3 GO:0016747 TK78_RS26955 7c1376a7f1b599896fca21dd2b00307c 264 Gene3D G3DSA:3.20.20.70 7 255 1.7E-56 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS26955 7c1376a7f1b599896fca21dd2b00307c 264 SUPERFAMILY SSF110399 4 242 6.67E-80 T 09-03-2017 IPR008867 Thiazole biosynthesis GO:0009228 KEGG: 00730+2.8.1.10|MetaCyc: PWY-6891|MetaCyc: PWY-6892 TK78_RS26955 7c1376a7f1b599896fca21dd2b00307c 264 Pfam PF05690 Thiazole biosynthesis protein ThiG 9 250 2.7E-105 T 09-03-2017 TK78_RS26955 7c1376a7f1b599896fca21dd2b00307c 264 Hamap MF_00443 Thiazole synthase [thiG]. 5 256 42.47 T 09-03-2017 IPR008867 Thiazole biosynthesis GO:0009228 KEGG: 00730+2.8.1.10|MetaCyc: PWY-6891|MetaCyc: PWY-6892 TK78_RS04820 a2430c89df64a61a11dea5dbb2858ea2 351 Pfam PF02653 Branched-chain amino acid transport system / permease component 61 336 9.0E-55 T 09-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 TK78_RS22895 5f51b7510ea5e3e979946663450b3d16 509 Pfam PF13589 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 37 137 1.2E-21 T 09-03-2017 TK78_RS22895 5f51b7510ea5e3e979946663450b3d16 509 Gene3D G3DSA:3.30.565.10 34 224 6.4E-23 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS22895 5f51b7510ea5e3e979946663450b3d16 509 SUPERFAMILY SSF55874 34 139 2.36E-14 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS03575 47203d9cb47a644d92e43fa5ac0c46f9 269 Gene3D G3DSA:3.40.50.150 2 269 6.5E-114 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS03575 47203d9cb47a644d92e43fa5ac0c46f9 269 SUPERFAMILY SSF53335 16 259 1.39E-47 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS03575 47203d9cb47a644d92e43fa5ac0c46f9 269 Pfam PF04672 S-adenosyl methyltransferase 7 269 9.0E-111 T 09-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type TK78_RS03575 47203d9cb47a644d92e43fa5ac0c46f9 269 PIRSF PIRSF017393 1 269 2.9E-100 T 09-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type TK78_RS09170 3805264b61f6886c4a9f3db8aa1f0d2d 240 Gene3D G3DSA:3.10.350.10 181 230 2.3E-6 T 09-03-2017 IPR018392 LysM domain TK78_RS09170 3805264b61f6886c4a9f3db8aa1f0d2d 240 Pfam PF01476 LysM domain 183 229 1.6E-5 T 09-03-2017 IPR018392 LysM domain TK78_RS06465 2542372ed3643e36f63c30a434a8fc5b 134 Pfam PF04472 Protein of unknown function (DUF552) 53 123 7.5E-19 T 09-03-2017 IPR007561 Cell division protein SepF/SepF-related GO:0090529 TK78_RS06465 2542372ed3643e36f63c30a434a8fc5b 134 Hamap MF_01197 Cell division protein SepF [sepF]. 1 131 14.628 T 09-03-2017 IPR023052 Cell division protein SepF GO:0090529 TK78_RS20180 a70b2eb4b0057da201f31ef6eac7bd5b 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 150 169 4.1E-20 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20180 a70b2eb4b0057da201f31ef6eac7bd5b 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 124 140 4.1E-20 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20180 a70b2eb4b0057da201f31ef6eac7bd5b 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 171 188 4.1E-20 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20180 a70b2eb4b0057da201f31ef6eac7bd5b 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 6 23 4.1E-20 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20180 a70b2eb4b0057da201f31ef6eac7bd5b 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 76 87 4.1E-20 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20180 a70b2eb4b0057da201f31ef6eac7bd5b 252 Pfam PF00106 short chain dehydrogenase 6 188 4.8E-48 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS20180 a70b2eb4b0057da201f31ef6eac7bd5b 252 Gene3D G3DSA:3.40.50.720 5 237 1.7E-61 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS20180 a70b2eb4b0057da201f31ef6eac7bd5b 252 SUPERFAMILY SSF51735 6 240 1.47E-59 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS32555 98fa8d7f45bfc1012667ab6c04f3e441 187 Pfam PF13298 DNA polymerase Ligase (LigD) 14 125 6.5E-36 T 09-03-2017 IPR014144 DNA ligase D, 3'-phosphoesterase domain TK78_RS32555 98fa8d7f45bfc1012667ab6c04f3e441 187 TIGRFAM TIGR02777 LigD_PE_dom: DNA ligase D, 3'-phosphoesterase domain 8 149 9.5E-51 T 09-03-2017 IPR014144 DNA ligase D, 3'-phosphoesterase domain TK78_RS29750 296a1dff5babaa3b27c546510d68d322 225 SUPERFAMILY SSF48371 16 188 1.22E-15 T 09-03-2017 IPR016024 Armadillo-type fold GO:0005488 TK78_RS29750 296a1dff5babaa3b27c546510d68d322 225 Gene3D G3DSA:1.25.10.10 16 189 1.1E-17 T 09-03-2017 IPR011989 Armadillo-like helical TK78_RS29750 296a1dff5babaa3b27c546510d68d322 225 Pfam PF13646 HEAT repeats 56 123 4.7E-8 T 09-03-2017 TK78_RS34140 a1295090e6cdbe4af15c9ed3927f64f8 350 Gene3D G3DSA:3.40.47.10 246 329 5.3E-7 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS34140 a1295090e6cdbe4af15c9ed3927f64f8 350 Gene3D G3DSA:3.40.47.10 20 121 1.5E-6 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS34140 a1295090e6cdbe4af15c9ed3927f64f8 350 Gene3D G3DSA:3.40.47.10 193 213 1.5E-6 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS34140 a1295090e6cdbe4af15c9ed3927f64f8 350 SUPERFAMILY SSF53901 1 116 1.56E-13 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS34140 a1295090e6cdbe4af15c9ed3927f64f8 350 SUPERFAMILY SSF53901 190 216 1.56E-13 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS34140 a1295090e6cdbe4af15c9ed3927f64f8 350 SUPERFAMILY SSF53901 221 335 1.73E-14 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS29565 ab36bec24c991714bfff6a7b7394a8da 242 Pfam PF07179 SseB protein N-terminal domain 22 142 8.3E-31 T 09-03-2017 IPR009839 SseB protein N-terminal domain TK78_RS04105 ced022571248dc22917898d6047a74b7 661 SUPERFAMILY SSF48452 513 628 9.21E-5 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS04105 ced022571248dc22917898d6047a74b7 661 Pfam PF17128 Domain of unknown function (DUF5107) 61 350 8.2E-41 T 09-03-2017 IPR033396 Domain of unknown function DUF5107 TK78_RS04105 ced022571248dc22917898d6047a74b7 661 Gene3D G3DSA:1.25.40.10 472 543 3.6E-4 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS04105 ced022571248dc22917898d6047a74b7 661 Gene3D G3DSA:1.25.40.10 593 622 3.6E-4 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS15390 82ee739b6d8209d725a1efa9139829a8 474 Pfam PF06965 Na+/H+ antiporter 1 34 406 6.0E-130 T 09-03-2017 IPR004670 Na+/H+ antiporter NhaA GO:0006814|GO:0006885|GO:0016021 TK78_RS15390 82ee739b6d8209d725a1efa9139829a8 474 TIGRFAM TIGR00773 NhaA: Na+/H+ antiporter NhaA 37 405 1.2E-96 T 09-03-2017 IPR004670 Na+/H+ antiporter NhaA GO:0006814|GO:0006885|GO:0016021 TK78_RS15390 82ee739b6d8209d725a1efa9139829a8 474 Hamap MF_01844 Na(+)/H(+) antiporter NhaA [nhaA]. 32 412 20.489 T 09-03-2017 IPR004670 Na+/H+ antiporter NhaA GO:0006814|GO:0006885|GO:0016021 TK78_RS15390 82ee739b6d8209d725a1efa9139829a8 474 Gene3D G3DSA:1.20.1530.10 32 412 2.5E-132 T 09-03-2017 IPR023171 Na/H antiporter domain TK78_RS14545 a40150a6abf0deb77ac7b9c9c13b159b 57 Gene3D G3DSA:1.10.1470.10 5 55 2.8E-9 T 09-03-2017 IPR008462 CsbD-like TK78_RS14545 a40150a6abf0deb77ac7b9c9c13b159b 57 Pfam PF05532 CsbD-like 5 55 2.4E-13 T 09-03-2017 IPR008462 CsbD-like TK78_RS14545 a40150a6abf0deb77ac7b9c9c13b159b 57 SUPERFAMILY SSF69047 4 55 7.72E-8 T 09-03-2017 IPR008462 CsbD-like TK78_RS33235 d2996135be184feb875a8756489c2a6d 287 Pfam PF00005 ABC transporter 23 170 3.3E-29 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS33235 d2996135be184feb875a8756489c2a6d 287 ProSitePatterns PS00211 ABC transporters family signature. 143 157 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS33235 d2996135be184feb875a8756489c2a6d 287 Gene3D G3DSA:3.40.50.300 4 240 7.4E-64 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33235 d2996135be184feb875a8756489c2a6d 287 SUPERFAMILY SSF52540 6 234 1.81E-60 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33235 d2996135be184feb875a8756489c2a6d 287 SMART SM00382 31 220 4.1E-16 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS00975 75b87277d3c553ad044171e8ec8a5109 121 Gene3D G3DSA:1.10.10.10 11 99 4.3E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS00975 75b87277d3c553ad044171e8ec8a5109 121 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 24 39 1.5E-9 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS00975 75b87277d3c553ad044171e8ec8a5109 121 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 56 71 1.5E-9 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS00975 75b87277d3c553ad044171e8ec8a5109 121 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 71 86 1.5E-9 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS00975 75b87277d3c553ad044171e8ec8a5109 121 Pfam PF12840 Helix-turn-helix domain 23 80 1.5E-10 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS00975 75b87277d3c553ad044171e8ec8a5109 121 SMART SM00418 22 100 2.2E-17 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS00975 75b87277d3c553ad044171e8ec8a5109 121 SUPERFAMILY SSF46785 12 99 3.98E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS19110 fea0691030670971d35d1d722dff71a3 134 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 7 90 2.2E-15 T 09-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS19110 fea0691030670971d35d1d722dff71a3 134 Gene3D G3DSA:2.30.110.10 6 132 1.0E-28 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS19110 fea0691030670971d35d1d722dff71a3 134 SUPERFAMILY SSF50475 5 132 7.52E-29 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS19110 fea0691030670971d35d1d722dff71a3 134 TIGRFAM TIGR03618 Rv1155_F420: PPOX class probable F420-dependent enzyme 10 132 3.9E-39 T 09-03-2017 IPR019920 F420-binding domain, putative TK78_RS14690 1d8d9b72c91ffca841aba151cf0cf56f 352 Pfam PF01032 FecCD transport family 38 347 1.3E-90 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS14690 1d8d9b72c91ffca841aba151cf0cf56f 352 SUPERFAMILY SSF81345 24 347 6.02E-80 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS14690 1d8d9b72c91ffca841aba151cf0cf56f 352 Gene3D G3DSA:1.10.3470.10 26 349 2.4E-102 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS30360 f4a46e2ff2e45aa0f83e56cb8899cd47 714 Hamap MF_00983 Probable primosomal protein N' [priA]. 56 713 20.908 T 09-03-2017 IPR005259 Primosomal protein N' GO:0003677|GO:0004003|GO:0006260|GO:0032508 TK78_RS30360 f4a46e2ff2e45aa0f83e56cb8899cd47 714 Gene3D G3DSA:3.40.50.300 227 318 2.4E-6 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS30360 f4a46e2ff2e45aa0f83e56cb8899cd47 714 SUPERFAMILY SSF52540 225 313 2.6E-5 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS26590 b6969e5e58db7a5808fd9efb72b99aa5 483 Pfam PF01593 Flavin containing amine oxidoreductase 218 466 3.6E-17 T 09-03-2017 IPR002937 Amine oxidase GO:0016491|GO:0055114 TK78_RS26590 b6969e5e58db7a5808fd9efb72b99aa5 483 SUPERFAMILY SSF51905 429 469 2.1E-43 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS26590 b6969e5e58db7a5808fd9efb72b99aa5 483 SUPERFAMILY SSF51905 176 327 2.1E-43 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS26590 b6969e5e58db7a5808fd9efb72b99aa5 483 SUPERFAMILY SSF51905 7 121 2.1E-43 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS26590 b6969e5e58db7a5808fd9efb72b99aa5 483 Gene3D G3DSA:3.50.50.60 263 330 4.0E-30 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS26590 b6969e5e58db7a5808fd9efb72b99aa5 483 Gene3D G3DSA:3.50.50.60 8 46 4.0E-30 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS26590 b6969e5e58db7a5808fd9efb72b99aa5 483 Gene3D G3DSA:3.50.50.60 429 471 4.0E-30 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS26590 b6969e5e58db7a5808fd9efb72b99aa5 483 Pfam PF13450 NAD(P)-binding Rossmann-like domain 12 60 2.4E-12 T 09-03-2017 TK78_RS07115 3a1409fea532531e554cc17a83ce9666 327 Gene3D G3DSA:3.40.50.2000 1 58 1.8E-10 T 09-03-2017 TK78_RS07115 3a1409fea532531e554cc17a83ce9666 327 Pfam PF06722 Protein of unknown function (DUF1205) 131 217 8.4E-13 T 09-03-2017 IPR010610 Domain of unknown function DUF1205 TK78_RS07115 3a1409fea532531e554cc17a83ce9666 327 Gene3D G3DSA:3.40.50.2000 182 305 1.3E-9 T 09-03-2017 TK78_RS07115 3a1409fea532531e554cc17a83ce9666 327 SUPERFAMILY SSF53756 1 325 3.59E-43 T 09-03-2017 TK78_RS10545 771ff74351d5603cf93bb5feefc5455c 226 SUPERFAMILY SSF51219 17 217 3.66E-47 T 09-03-2017 IPR016031 Tryptophan RNA-binding attenuator protein-like domain TK78_RS10545 771ff74351d5603cf93bb5feefc5455c 226 Gene3D G3DSA:3.60.160.10 13 216 1.1E-42 T 09-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 TK78_RS10545 771ff74351d5603cf93bb5feefc5455c 226 Pfam PF01987 Mitochondrial biogenesis AIM24 19 214 1.4E-36 T 09-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 TK78_RS05605 bf2f8d13d3c4c58c2f10dcc55e93f8ca 288 SUPERFAMILY SSF56112 11 259 1.22E-29 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS05605 bf2f8d13d3c4c58c2f10dcc55e93f8ca 288 Gene3D G3DSA:3.90.1200.10 94 272 2.5E-14 T 09-03-2017 TK78_RS05605 bf2f8d13d3c4c58c2f10dcc55e93f8ca 288 Pfam PF01636 Phosphotransferase enzyme family 45 235 8.4E-17 T 09-03-2017 IPR002575 Aminoglycoside phosphotransferase TK78_RS32890 7dd60f303f8edf1b8f9f602d0581cfdb 434 PIRSF PIRSF037118 4 434 1.2E-168 T 09-03-2017 IPR017115 Tellurite resistance, TerA TK78_RS32890 7dd60f303f8edf1b8f9f602d0581cfdb 434 Pfam PF02342 TerD domain 5 172 1.7E-45 T 09-03-2017 IPR003325 TerD domain GO:0006950 TK78_RS32890 7dd60f303f8edf1b8f9f602d0581cfdb 434 Gene3D G3DSA:2.60.60.30 19 170 1.0E-34 T 09-03-2017 TK78_RS32890 7dd60f303f8edf1b8f9f602d0581cfdb 434 Gene3D G3DSA:2.60.60.30 249 358 5.6E-4 T 09-03-2017 TK78_RS24150 4936a74da65375fd4bd31acc2b4d6069 313 Gene3D G3DSA:1.10.3720.10 7 302 5.6E-55 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS24150 4936a74da65375fd4bd31acc2b4d6069 313 SUPERFAMILY SSF161098 58 299 7.59E-51 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS24150 4936a74da65375fd4bd31acc2b4d6069 313 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 93 291 2.0E-11 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS24150 4936a74da65375fd4bd31acc2b4d6069 313 SUPERFAMILY SSF160964 19 62 2.75E-5 T 09-03-2017 TK78_RS31145 bfb841a9dde4ca1ffdcaee32363cb1d6 427 Gene3D G3DSA:3.30.470.20 119 348 1.9E-29 T 09-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 TK78_RS31145 bfb841a9dde4ca1ffdcaee32363cb1d6 427 SMART SM01209 126 305 1.1E-4 T 09-03-2017 TK78_RS31145 bfb841a9dde4ca1ffdcaee32363cb1d6 427 SUPERFAMILY SSF56059 125 339 5.66E-36 T 09-03-2017 TK78_RS31145 bfb841a9dde4ca1ffdcaee32363cb1d6 427 Pfam PF13535 ATP-grasp domain 161 308 4.6E-19 T 09-03-2017 TK78_RS11020 670347e13f7277462c1457739d94497a 337 Gene3D G3DSA:3.40.50.1820 28 332 2.1E-57 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS11020 670347e13f7277462c1457739d94497a 337 SUPERFAMILY SSF53474 19 312 4.53E-21 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS11020 670347e13f7277462c1457739d94497a 337 Pfam PF05448 Acetyl xylan esterase (AXE1) 30 306 6.0E-24 T 09-03-2017 IPR008391 Acetyl xylan esterase TK78_RS11715 576929a6e2e448bbb2007a64978d403a 149 SUPERFAMILY SSF46785 22 125 2.12E-35 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS11715 576929a6e2e448bbb2007a64978d403a 149 Pfam PF01638 HxlR-like helix-turn-helix 33 120 1.4E-32 T 09-03-2017 IPR002577 Helix-turn-helix, HxlR type TK78_RS11715 576929a6e2e448bbb2007a64978d403a 149 Gene3D G3DSA:1.10.10.10 24 123 4.1E-43 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS30785 e0f6b833579092c013b66f13ea47aca6 157 SUPERFAMILY SSF103256 3 136 1.44E-46 T 09-03-2017 IPR003729 Bifunctional nuclease domain GO:0004518 TK78_RS30785 e0f6b833579092c013b66f13ea47aca6 157 Pfam PF02577 Bifunctional nuclease 6 128 3.5E-45 T 09-03-2017 IPR003729 Bifunctional nuclease domain GO:0004518 TK78_RS33615 2544b772edd553f3beb18c25ced3d592 423 PRINTS PR00407 Eukaryotic molybdopterin domain signature 326 341 3.1E-5 T 09-03-2017 IPR008335 Eukaryotic molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-1614517 TK78_RS33615 2544b772edd553f3beb18c25ced3d592 423 PRINTS PR00407 Eukaryotic molybdopterin domain signature 392 405 3.1E-5 T 09-03-2017 IPR008335 Eukaryotic molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-1614517 TK78_RS33615 2544b772edd553f3beb18c25ced3d592 423 SUPERFAMILY SSF56524 285 421 5.36E-32 T 09-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 TK78_RS33615 2544b772edd553f3beb18c25ced3d592 423 Pfam PF00174 Oxidoreductase molybdopterin binding domain 286 420 2.3E-23 T 09-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 TK78_RS33615 2544b772edd553f3beb18c25ced3d592 423 Gene3D G3DSA:3.90.420.10 268 420 3.0E-31 T 09-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 TK78_RS22790 90c138b51fc9e51c72103ce875fe91b5 596 Pfam PF06259 Alpha/beta hydrolase 360 532 1.9E-32 T 09-03-2017 IPR010427 Protein of unknown function DUF1023 TK78_RS10635 5a6959b38fb83eb86106dc872653aaf4 392 Gene3D G3DSA:3.40.250.10 274 387 1.1E-26 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS10635 5a6959b38fb83eb86106dc872653aaf4 392 Pfam PF00899 ThiF family 21 254 2.3E-66 T 09-03-2017 IPR000594 THIF-type NAD/FAD binding fold GO:0008641 TK78_RS10635 5a6959b38fb83eb86106dc872653aaf4 392 Gene3D G3DSA:3.40.50.720 12 258 5.2E-79 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS10635 5a6959b38fb83eb86106dc872653aaf4 392 SUPERFAMILY SSF69572 8 357 4.45E-106 T 09-03-2017 IPR000594 THIF-type NAD/FAD binding fold GO:0008641 TK78_RS10635 5a6959b38fb83eb86106dc872653aaf4 392 SMART SM00450 290 387 2.9E-23 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS10635 5a6959b38fb83eb86106dc872653aaf4 392 Pfam PF00581 Rhodanese-like domain 290 383 7.1E-13 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS27265 a35072cee73319e4b66d3dff29259ba3 213 Gene3D G3DSA:3.40.50.880 4 211 4.7E-74 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS27265 a35072cee73319e4b66d3dff29259ba3 213 Pfam PF00117 Glutamine amidotransferase class-I 9 206 1.7E-18 T 09-03-2017 IPR017926 Glutamine amidotransferase TK78_RS27265 a35072cee73319e4b66d3dff29259ba3 213 TIGRFAM TIGR01855 IMP_synth_hisH: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit 7 211 1.2E-61 T 09-03-2017 IPR010139 Imidazole glycerol phosphate synthase, subunit H GO:0000105|GO:0005737|GO:0016763 TK78_RS27265 a35072cee73319e4b66d3dff29259ba3 213 SUPERFAMILY SSF52317 5 211 5.33E-52 T 09-03-2017 IPR029062 Class I glutamine amidotransferase-like TK78_RS27265 a35072cee73319e4b66d3dff29259ba3 213 PIRSF PIRSF000495 5 213 2.0E-66 T 09-03-2017 IPR010139 Imidazole glycerol phosphate synthase, subunit H GO:0000105|GO:0005737|GO:0016763 TK78_RS27265 a35072cee73319e4b66d3dff29259ba3 213 Hamap MF_00278 Imidazole glycerol phosphate synthase subunit HisH [hisH]. 6 212 31.219 T 09-03-2017 IPR010139 Imidazole glycerol phosphate synthase, subunit H GO:0000105|GO:0005737|GO:0016763 TK78_RS32995 9a1898af1c2ec604124fae02f0e6d63a 145 Pfam PF10025 Uncharacterized conserved protein (DUF2267) 19 132 1.3E-20 T 09-03-2017 IPR018727 Protein of unknown function DUF2267 TK78_RS30660 00844b1042ca67465d7350b53eb19715 147 Pfam PF03259 Roadblock/LC7 domain 19 110 6.6E-25 T 09-03-2017 IPR004942 Roadblock/LAMTOR2 domain TK78_RS30660 00844b1042ca67465d7350b53eb19715 147 SUPERFAMILY SSF103196 16 139 1.03E-33 T 09-03-2017 TK78_RS30660 00844b1042ca67465d7350b53eb19715 147 Gene3D G3DSA:3.30.450.30 18 136 1.5E-25 T 09-03-2017 TK78_RS30660 00844b1042ca67465d7350b53eb19715 147 SMART SM00960 20 110 3.1E-27 T 09-03-2017 IPR004942 Roadblock/LAMTOR2 domain TK78_RS10150 be4d2eb6105825dbd5245aa2dbb59312 395 Pfam PF06889 Protein of unknown function (DUF1266) 200 394 3.5E-41 T 09-03-2017 IPR009677 Protein of unknown function DUF1266 TK78_RS29135 e14135be5e9212217ac6794e90e9fff5 141 PIRSF PIRSF021320 6 141 8.9E-39 T 09-03-2017 IPR009326 Protein of unknown function DUF984 TK78_RS29135 e14135be5e9212217ac6794e90e9fff5 141 SMART SM01022 12 138 1.1E-30 T 09-03-2017 IPR007374 ASCH domain TK78_RS29135 e14135be5e9212217ac6794e90e9fff5 141 Pfam PF04266 ASCH domain 19 138 1.8E-17 T 09-03-2017 IPR007374 ASCH domain TK78_RS29135 e14135be5e9212217ac6794e90e9fff5 141 SUPERFAMILY SSF88697 15 138 2.73E-31 T 09-03-2017 IPR015947 PUA-like domain TK78_RS29135 e14135be5e9212217ac6794e90e9fff5 141 Gene3D G3DSA:3.10.400.10 12 139 1.1E-43 T 09-03-2017 TK78_RS03300 1eef275b532a22fd15851ce4d6761f41 314 Pfam PF09995 Uncharacterized protein conserved in bacteria (DUF2236) 44 284 2.5E-54 T 09-03-2017 IPR018713 Domain of unknown function DUF2236 TK78_RS05915 30bc57fdef3e45e174f338cb8e84f0d1 220 Pfam PF11452 Protein of unknown function (DUF3000) 28 201 5.4E-71 T 09-03-2017 IPR021555 Protein of unknown function DUF3000 TK78_RS20615 f583ee1bbd103d4e350ff8576a091841 216 Gene3D G3DSA:3.40.50.300 2 192 6.9E-12 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS20615 f583ee1bbd103d4e350ff8576a091841 216 SUPERFAMILY SSF52540 2 192 2.22E-16 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS20615 f583ee1bbd103d4e350ff8576a091841 216 Pfam PF13238 AAA domain 2 134 3.9E-7 T 09-03-2017 TK78_RS12175 cc931abe5af0795d4c4f3943cd5616f1 421 Pfam PF02653 Branched-chain amino acid transport system / permease component 58 346 2.5E-35 T 09-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 TK78_RS27070 d96b771dafd0e849a946681800daff5c 662 SUPERFAMILY SSF56601 296 644 3.93E-87 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS27070 d96b771dafd0e849a946681800daff5c 662 Pfam PF00905 Penicillin binding protein transpeptidase domain 321 636 1.1E-74 T 09-03-2017 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 TK78_RS27070 d96b771dafd0e849a946681800daff5c 662 Gene3D G3DSA:3.40.710.10 303 641 1.5E-91 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS27070 d96b771dafd0e849a946681800daff5c 662 SUPERFAMILY SSF56519 102 295 5.62E-33 T 09-03-2017 IPR005311 Penicillin-binding protein, dimerisation domain GO:0008658 TK78_RS27070 d96b771dafd0e849a946681800daff5c 662 Pfam PF03717 Penicillin-binding Protein dimerisation domain 106 271 4.5E-14 T 09-03-2017 IPR005311 Penicillin-binding protein, dimerisation domain GO:0008658 TK78_RS27070 d96b771dafd0e849a946681800daff5c 662 Gene3D G3DSA:3.90.1310.10 215 302 2.8E-25 T 09-03-2017 TK78_RS06355 8e1b2dd1e7ac7345c0c2c415befa9cdd 550 Pfam PF00361 Proton-conducting membrane transporter 131 419 4.0E-63 T 09-03-2017 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS06355 8e1b2dd1e7ac7345c0c2c415befa9cdd 550 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 376 402 4.3E-17 T 09-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS06355 8e1b2dd1e7ac7345c0c2c415befa9cdd 550 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 238 262 4.3E-17 T 09-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS06355 8e1b2dd1e7ac7345c0c2c415befa9cdd 550 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 324 343 4.3E-17 T 09-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS06355 8e1b2dd1e7ac7345c0c2c415befa9cdd 550 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 137 156 4.3E-17 T 09-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS06355 8e1b2dd1e7ac7345c0c2c415befa9cdd 550 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 167 191 4.3E-17 T 09-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS11115 3f8cb7fdc4b275ac4a6722948adbc7e8 204 Gene3D G3DSA:1.10.357.10 4 200 6.7E-30 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS11115 3f8cb7fdc4b275ac4a6722948adbc7e8 204 Pfam PF00440 Bacterial regulatory proteins, tetR family 19 65 3.4E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS11115 3f8cb7fdc4b275ac4a6722948adbc7e8 204 SUPERFAMILY SSF46689 8 80 4.98E-14 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS23745 34435dcc05a28b8fa77e62b18d542483 241 Pfam PF14518 Iron-containing redox enzyme 74 211 1.6E-8 T 09-03-2017 IPR028201 PqqC-like protein TK78_RS23745 34435dcc05a28b8fa77e62b18d542483 241 SMART SM01236 76 175 1.2E-6 T 09-03-2017 TK78_RS23745 34435dcc05a28b8fa77e62b18d542483 241 SUPERFAMILY SSF48613 36 219 8.22E-22 T 09-03-2017 IPR016084 Haem oxygenase-like, multi-helical Reactome: R-HSA-189483|Reactome: R-HSA-917937 TK78_RS23745 34435dcc05a28b8fa77e62b18d542483 241 Gene3D G3DSA:1.20.910.10 77 214 6.8E-7 T 09-03-2017 IPR016084 Haem oxygenase-like, multi-helical Reactome: R-HSA-189483|Reactome: R-HSA-917937 TK78_RS18135 53874f16e6a446f7342252c9d84b77c4 40 Gene3D G3DSA:3.40.50.300 5 39 3.8E-11 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18135 53874f16e6a446f7342252c9d84b77c4 40 Pfam PF03796 DnaB-like helicase C terminal domain 3 36 5.8E-7 T 09-03-2017 IPR007694 DNA helicase, DnaB-like, C-terminal GO:0003678|GO:0005524|GO:0006260 Reactome: R-HSA-2151201 TK78_RS07335 f164ff95df339b734eeb2b3d4a2d8604 178 Pfam PF02342 TerD domain 2 166 3.1E-19 T 09-03-2017 IPR003325 TerD domain GO:0006950 TK78_RS07335 f164ff95df339b734eeb2b3d4a2d8604 178 Gene3D G3DSA:2.60.60.30 7 168 1.2E-40 T 09-03-2017 TK78_RS15605 9d05c3960d0685e560f6486d94aa5341 200 Pfam PF00583 Acetyltransferase (GNAT) family 98 172 1.3E-18 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS15605 9d05c3960d0685e560f6486d94aa5341 200 Gene3D G3DSA:3.40.630.30 8 198 2.9E-34 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS15605 9d05c3960d0685e560f6486d94aa5341 200 SUPERFAMILY SSF55729 3 26 1.86E-27 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS15605 9d05c3960d0685e560f6486d94aa5341 200 SUPERFAMILY SSF55729 56 177 1.86E-27 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS21950 cb367db118d8c63f7dc66e49d7f95de7 332 SUPERFAMILY SSF48150 132 311 6.67E-27 T 09-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 TK78_RS21950 cb367db118d8c63f7dc66e49d7f95de7 332 Gene3D G3DSA:1.10.340.30 146 258 4.0E-18 T 09-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 TK78_RS27395 fd57034797c9c530b4405d841552a2c3 432 SUPERFAMILY SSF101478 31 376 2.48E-34 T 09-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 TK78_RS27395 fd57034797c9c530b4405d841552a2c3 432 Pfam PF03747 ADP-ribosylglycohydrolase 38 366 3.3E-33 T 09-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 TK78_RS20770 cf71d77d90adbdc3a11bf095dcc7f3d4 425 Gene3D G3DSA:3.40.390.10 213 290 1.7E-7 T 09-03-2017 IPR024079 Metallopeptidase, catalytic domain GO:0008237 TK78_RS20770 cf71d77d90adbdc3a11bf095dcc7f3d4 425 SUPERFAMILY SSF55486 217 289 2.86E-5 T 09-03-2017 TK78_RS20770 cf71d77d90adbdc3a11bf095dcc7f3d4 425 TIGRFAM TIGR03296 M6dom_TIGR03296: M6 family metalloprotease domain 89 352 1.9E-52 T 09-03-2017 IPR008757 Peptidase M6-like, domain GO:0006508|GO:0008233 TK78_RS23480 97db53af132e19e0ab4c4e25e21b27ea 221 Pfam PF05719 Golgi phosphoprotein 3 (GPP34) 5 203 3.4E-50 T 09-03-2017 IPR008628 Golgi phosphoprotein 3 GO:0048193|GO:0070273 TK78_RS23480 97db53af132e19e0ab4c4e25e21b27ea 221 Gene3D G3DSA:1.10.3630.10 3 213 1.5E-40 T 09-03-2017 TK78_RS03010 798abaad503f79baa46a8483e794c694 725 Gene3D G3DSA:3.30.565.10 280 405 2.2E-14 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS03010 798abaad503f79baa46a8483e794c694 725 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 299 405 9.3E-8 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS03010 798abaad503f79baa46a8483e794c694 725 SUPERFAMILY SSF55874 293 405 3.27E-15 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS03010 798abaad503f79baa46a8483e794c694 725 SMART SM00387 294 407 2.8E-5 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS02260 af4c9d1132eb9c015925dc15874c5670 153 Pfam PF00582 Universal stress protein family 17 153 1.9E-21 T 09-03-2017 IPR006016 UspA GO:0006950 TK78_RS02260 af4c9d1132eb9c015925dc15874c5670 153 PRINTS PR01438 Universal stress protein signature 16 34 1.5E-5 T 09-03-2017 IPR006015 Universal stress protein A TK78_RS02260 af4c9d1132eb9c015925dc15874c5670 153 PRINTS PR01438 Universal stress protein signature 131 153 1.5E-5 T 09-03-2017 IPR006015 Universal stress protein A TK78_RS02260 af4c9d1132eb9c015925dc15874c5670 153 Gene3D G3DSA:3.40.50.620 16 153 9.3E-24 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS02260 af4c9d1132eb9c015925dc15874c5670 153 SUPERFAMILY SSF52402 19 153 1.42E-23 T 09-03-2017 TK78_RS05140 3e1ccda4ee9af98b4889854d821e3656 169 Pfam PF08327 Activator of Hsp90 ATPase homolog 1-like protein 26 141 1.4E-19 T 09-03-2017 IPR013538 Activator of Hsp90 ATPase homologue 1-like GO:0006950 TK78_RS05140 3e1ccda4ee9af98b4889854d821e3656 169 Gene3D G3DSA:3.30.530.20 14 146 1.2E-26 T 09-03-2017 IPR023393 START-like domain TK78_RS05140 3e1ccda4ee9af98b4889854d821e3656 169 SUPERFAMILY SSF55961 2 164 8.52E-34 T 09-03-2017 TK78_RS13430 8d311ca08732cab2a91a236b08d66fc8 396 Pfam PF07730 Histidine kinase 199 264 6.8E-14 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS13430 8d311ca08732cab2a91a236b08d66fc8 396 Pfam PF13796 Putative sensor 30 147 2.7E-29 T 09-03-2017 IPR025828 Putative sensor domain TK78_RS13430 8d311ca08732cab2a91a236b08d66fc8 396 SUPERFAMILY SSF55874 283 385 3.7E-10 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS00745 a8eb967065f652a728f85aa13f76b44c 208 Gene3D G3DSA:1.10.357.10 8 186 1.7E-34 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS00745 a8eb967065f652a728f85aa13f76b44c 208 Pfam PF00440 Bacterial regulatory proteins, tetR family 17 62 3.2E-13 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS00745 a8eb967065f652a728f85aa13f76b44c 208 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 17 30 6.2E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS00745 a8eb967065f652a728f85aa13f76b44c 208 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 38 61 6.2E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS00745 a8eb967065f652a728f85aa13f76b44c 208 SUPERFAMILY SSF46689 4 80 2.05E-17 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS00745 a8eb967065f652a728f85aa13f76b44c 208 SUPERFAMILY SSF48498 86 186 3.86E-15 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS21130 bfa86299ce556c604077a74582189765 791 Gene3D G3DSA:3.30.565.10 296 376 9.4E-4 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS21130 bfa86299ce556c604077a74582189765 791 SUPERFAMILY SSF55874 269 377 8.68E-8 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS01470 4f0d69da0c17f779f81a2fcf3f0d6475 300 Gene3D G3DSA:1.10.10.10 7 87 2.5E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS01470 4f0d69da0c17f779f81a2fcf3f0d6475 300 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 8 63 4.5E-17 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS01470 4f0d69da0c17f779f81a2fcf3f0d6475 300 SUPERFAMILY SSF46785 6 106 1.76E-18 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS23630 d2ef1b1362a45e71f6d3184e09c887e8 195 Pfam PF00440 Bacterial regulatory proteins, tetR family 15 59 1.6E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS23630 d2ef1b1362a45e71f6d3184e09c887e8 195 SUPERFAMILY SSF46689 4 70 3.75E-13 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS23630 d2ef1b1362a45e71f6d3184e09c887e8 195 Gene3D G3DSA:1.10.357.10 10 193 6.8E-30 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS23785 4559e66a80108cc54a9d920b5aeb5dcd 392 SUPERFAMILY SSF47413 24 82 3.29E-15 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS23785 4559e66a80108cc54a9d920b5aeb5dcd 392 Pfam PF13377 Periplasmic binding protein-like domain 211 387 1.5E-31 T 09-03-2017 TK78_RS23785 4559e66a80108cc54a9d920b5aeb5dcd 392 Pfam PF00356 Bacterial regulatory proteins, lacI family 26 71 1.3E-15 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS23785 4559e66a80108cc54a9d920b5aeb5dcd 392 ProSitePatterns PS00356 LacI-type HTH domain signature. 27 45 - T 09-03-2017 TK78_RS23785 4559e66a80108cc54a9d920b5aeb5dcd 392 Gene3D G3DSA:1.10.260.40 25 84 5.6E-20 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS23785 4559e66a80108cc54a9d920b5aeb5dcd 392 Gene3D G3DSA:3.40.50.2300 216 366 2.2E-54 T 09-03-2017 TK78_RS23785 4559e66a80108cc54a9d920b5aeb5dcd 392 SMART SM00354 24 94 1.3E-23 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS23785 4559e66a80108cc54a9d920b5aeb5dcd 392 Gene3D G3DSA:3.40.50.2300 85 215 1.2E-42 T 09-03-2017 TK78_RS23785 4559e66a80108cc54a9d920b5aeb5dcd 392 SUPERFAMILY SSF53822 84 390 3.93E-57 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS17815 69ba6b11684e09f4ce2c44ca55b48eeb 365 Pfam PF01594 Domain of unknown function DUF20 24 331 6.3E-55 T 09-03-2017 IPR002549 Transmembrane protein TqsA-like TK78_RS13485 89b192db4e49cbb7ad438798def33801 155 SUPERFAMILY SSF54593 14 154 5.45E-8 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS13485 89b192db4e49cbb7ad438798def33801 155 Gene3D G3DSA:3.10.180.10 14 154 4.0E-9 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS25420 8969b2603cb0db12be9c16261c11f6b9 142 Pfam PF02566 OsmC-like protein 43 139 4.3E-19 T 09-03-2017 IPR003718 OsmC/Ohr family TK78_RS25420 8969b2603cb0db12be9c16261c11f6b9 142 TIGRFAM TIGR03561 organ_hyd_perox: peroxiredoxin, Ohr subfamily 10 141 2.9E-56 T 09-03-2017 IPR019953 Organic hydroperoxide resistance protein famiy GO:0006979 TK78_RS25420 8969b2603cb0db12be9c16261c11f6b9 142 Gene3D G3DSA:2.20.25.10 7 49 1.6E-18 T 09-03-2017 TK78_RS25420 8969b2603cb0db12be9c16261c11f6b9 142 SUPERFAMILY SSF82784 3 141 1.22E-43 T 09-03-2017 IPR003718 OsmC/Ohr family TK78_RS25420 8969b2603cb0db12be9c16261c11f6b9 142 Gene3D G3DSA:3.30.300.20 50 141 3.9E-37 T 09-03-2017 IPR015946 K homology domain-like, alpha/beta TK78_RS32465 2bd26971fd1c89e2e4284b106b9d4ad5 327 Pfam PF11271 Protein of unknown function (DUF3068) 8 304 1.3E-70 T 09-03-2017 IPR021424 Protein of unknown function DUF3068 TK78_RS29150 bcee7b078d8e9fa1449b915fddcb85ad 465 PIRSF PIRSF002746 20 465 2.0E-141 T 09-03-2017 IPR003474 Gluconate transporter GO:0015128|GO:0016020|GO:0035429 TK78_RS29150 bcee7b078d8e9fa1449b915fddcb85ad 465 TIGRFAM TIGR00791 gntP: transporter, gluconate:H+ symporter (GntP) family 27 465 2.3E-135 T 09-03-2017 IPR003474 Gluconate transporter GO:0015128|GO:0016020|GO:0035429 TK78_RS29150 bcee7b078d8e9fa1449b915fddcb85ad 465 Pfam PF02447 GntP family permease 27 463 9.9E-140 T 09-03-2017 IPR003474 Gluconate transporter GO:0015128|GO:0016020|GO:0035429 TK78_RS06425 1f01b4479604495bca447b7ce33eb255 334 Pfam PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 156 329 5.9E-51 T 09-03-2017 IPR006131 Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain GO:0006520|GO:0016597|GO:0016743 TK78_RS06425 1f01b4479604495bca447b7ce33eb255 334 Pfam PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 8 148 8.0E-44 T 09-03-2017 IPR006132 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding GO:0006520|GO:0016743 TK78_RS06425 1f01b4479604495bca447b7ce33eb255 334 SUPERFAMILY SSF53671 4 332 7.46E-94 T 09-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TK78_RS06425 1f01b4479604495bca447b7ce33eb255 334 ProSitePatterns PS00097 Aspartate and ornithine carbamoyltransferases signature. 53 60 - T 09-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TK78_RS06425 1f01b4479604495bca447b7ce33eb255 334 TIGRFAM TIGR00658 orni_carb_tr: ornithine carbamoyltransferase 8 331 8.3E-118 T 09-03-2017 IPR002292 Ornithine/putrescine carbamoyltransferase GO:0016743 KEGG: 00220+2.1.3.3|MetaCyc: PWY-4981|MetaCyc: PWY-4984|MetaCyc: PWY-7400|Reactome: R-HSA-70635 TK78_RS06425 1f01b4479604495bca447b7ce33eb255 334 PRINTS PR00102 Ornithine carbamoyltransferase signature 124 138 2.9E-31 T 09-03-2017 IPR002292 Ornithine/putrescine carbamoyltransferase GO:0016743 KEGG: 00220+2.1.3.3|MetaCyc: PWY-4981|MetaCyc: PWY-4984|MetaCyc: PWY-7400|Reactome: R-HSA-70635 TK78_RS06425 1f01b4479604495bca447b7ce33eb255 334 PRINTS PR00102 Ornithine carbamoyltransferase signature 310 321 2.9E-31 T 09-03-2017 IPR002292 Ornithine/putrescine carbamoyltransferase GO:0016743 KEGG: 00220+2.1.3.3|MetaCyc: PWY-4981|MetaCyc: PWY-4984|MetaCyc: PWY-7400|Reactome: R-HSA-70635 TK78_RS06425 1f01b4479604495bca447b7ce33eb255 334 PRINTS PR00102 Ornithine carbamoyltransferase signature 84 97 2.9E-31 T 09-03-2017 IPR002292 Ornithine/putrescine carbamoyltransferase GO:0016743 KEGG: 00220+2.1.3.3|MetaCyc: PWY-4981|MetaCyc: PWY-4984|MetaCyc: PWY-7400|Reactome: R-HSA-70635 TK78_RS06425 1f01b4479604495bca447b7ce33eb255 334 PRINTS PR00102 Ornithine carbamoyltransferase signature 229 239 2.9E-31 T 09-03-2017 IPR002292 Ornithine/putrescine carbamoyltransferase GO:0016743 KEGG: 00220+2.1.3.3|MetaCyc: PWY-4981|MetaCyc: PWY-4984|MetaCyc: PWY-7400|Reactome: R-HSA-70635 TK78_RS06425 1f01b4479604495bca447b7ce33eb255 334 PRINTS PR00102 Ornithine carbamoyltransferase signature 51 65 2.9E-31 T 09-03-2017 IPR002292 Ornithine/putrescine carbamoyltransferase GO:0016743 KEGG: 00220+2.1.3.3|MetaCyc: PWY-4981|MetaCyc: PWY-4984|MetaCyc: PWY-7400|Reactome: R-HSA-70635 TK78_RS06425 1f01b4479604495bca447b7ce33eb255 334 Gene3D G3DSA:3.40.50.1370 5 143 2.6E-52 T 09-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TK78_RS06425 1f01b4479604495bca447b7ce33eb255 334 Gene3D G3DSA:3.40.50.1370 144 318 4.9E-66 T 09-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TK78_RS06425 1f01b4479604495bca447b7ce33eb255 334 Hamap MF_01109 Ornithine carbamoyltransferase, catabolic [argI]. 7 332 79.989 T 09-03-2017 IPR024904 Ornithine carbamoyltransferase GO:0004585|GO:0006591 KEGG: 00220+2.1.3.3|MetaCyc: PWY-4981|MetaCyc: PWY-4984|MetaCyc: PWY-7400 TK78_RS06425 1f01b4479604495bca447b7ce33eb255 334 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 135 146 4.0E-26 T 09-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TK78_RS06425 1f01b4479604495bca447b7ce33eb255 334 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 53 72 4.0E-26 T 09-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TK78_RS06425 1f01b4479604495bca447b7ce33eb255 334 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 296 319 4.0E-26 T 09-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TK78_RS06425 1f01b4479604495bca447b7ce33eb255 334 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 267 276 4.0E-26 T 09-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TK78_RS10340 651411cefeea1498aea31ec90bc91321 253 Pfam PF06182 ABC-2 family transporter protein 26 252 1.1E-19 T 09-03-2017 IPR010390 Protein of unknown function DUF990 TK78_RS24450 d42cddd4612d996b4f640c4a3f33452b 353 Pfam PF04085 rod shape-determining protein MreC 131 270 1.0E-34 T 09-03-2017 IPR007221 Rod shape-determining protein MreC GO:0008360 TK78_RS24450 d42cddd4612d996b4f640c4a3f33452b 353 TIGRFAM TIGR00219 mreC: rod shape-determining protein MreC 10 272 1.7E-27 T 09-03-2017 IPR007221 Rod shape-determining protein MreC GO:0008360 TK78_RS08130 7bb8103b28073146703df854d53145c6 252 Pfam PF00717 Peptidase S24-like 45 114 2.0E-14 T 09-03-2017 IPR019759 Peptidase S24/S26A/S26B TK78_RS08130 7bb8103b28073146703df854d53145c6 252 SUPERFAMILY SSF51306 40 194 3.14E-38 T 09-03-2017 IPR015927 Peptidase S24/S26A/S26B/S26C TK78_RS08130 7bb8103b28073146703df854d53145c6 252 Gene3D G3DSA:2.10.109.10 145 193 2.4E-29 T 09-03-2017 IPR028360 Peptidase S24/S26, beta-ribbon domain TK78_RS08130 7bb8103b28073146703df854d53145c6 252 Gene3D G3DSA:2.10.109.10 39 99 2.4E-29 T 09-03-2017 IPR028360 Peptidase S24/S26, beta-ribbon domain TK78_RS08130 7bb8103b28073146703df854d53145c6 252 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 39 55 1.7E-19 T 09-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 TK78_RS08130 7bb8103b28073146703df854d53145c6 252 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 89 101 1.7E-19 T 09-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 TK78_RS08130 7bb8103b28073146703df854d53145c6 252 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 145 164 1.7E-19 T 09-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 TK78_RS08130 7bb8103b28073146703df854d53145c6 252 TIGRFAM TIGR02227 sigpep_I_bact: signal peptidase I 26 192 1.2E-39 T 09-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 TK78_RS26930 c818f20a0c6244cddc126daa7540a8ab 80 Pfam PF04324 BFD-like [2Fe-2S] binding domain 2 50 3.2E-11 T 09-03-2017 IPR007419 BFD-like [2Fe-2S]-binding domain TK78_RS23590 1bd5dae59820168645e67ce6be5cc322 306 Gene3D G3DSA:3.40.50.1820 38 303 5.6E-68 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS23590 1bd5dae59820168645e67ce6be5cc322 306 SUPERFAMILY SSF53474 44 303 1.4E-55 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS23590 1bd5dae59820168645e67ce6be5cc322 306 Pfam PF07859 alpha/beta hydrolase fold 87 282 1.8E-47 T 09-03-2017 IPR013094 Alpha/beta hydrolase fold-3 GO:0008152|GO:0016787 TK78_RS04785 84e1a8cdbee2f16511d9b184e6053cef 428 SUPERFAMILY SSF53474 7 252 1.64E-58 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04785 84e1a8cdbee2f16511d9b184e6053cef 428 PRINTS PR00111 Alpha/beta hydrolase fold signature 102 115 3.6E-9 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS04785 84e1a8cdbee2f16511d9b184e6053cef 428 PRINTS PR00111 Alpha/beta hydrolase fold signature 201 215 3.6E-9 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS04785 84e1a8cdbee2f16511d9b184e6053cef 428 PRINTS PR00111 Alpha/beta hydrolase fold signature 88 101 3.6E-9 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS04785 84e1a8cdbee2f16511d9b184e6053cef 428 PRINTS PR00111 Alpha/beta hydrolase fold signature 45 60 3.6E-9 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS04785 84e1a8cdbee2f16511d9b184e6053cef 428 SUPERFAMILY SSF69118 303 423 1.2E-36 T 09-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 TK78_RS04785 84e1a8cdbee2f16511d9b184e6053cef 428 Pfam PF02627 Carboxymuconolactone decarboxylase family 335 417 1.4E-24 T 09-03-2017 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 TK78_RS04785 84e1a8cdbee2f16511d9b184e6053cef 428 Pfam PF00561 alpha/beta hydrolase fold 20 124 1.5E-15 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS04785 84e1a8cdbee2f16511d9b184e6053cef 428 Gene3D G3DSA:1.20.1290.10 303 424 5.1E-30 T 09-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 TK78_RS04785 84e1a8cdbee2f16511d9b184e6053cef 428 Gene3D G3DSA:3.40.50.1820 6 255 2.5E-57 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS11860 f0306dae422828deb00e59525f4ec8b9 181 Pfam PF04545 Sigma-70, region 4 97 146 3.4E-7 T 09-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS11860 f0306dae422828deb00e59525f4ec8b9 181 SUPERFAMILY SSF88659 97 147 5.79E-9 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS11860 f0306dae422828deb00e59525f4ec8b9 181 Gene3D G3DSA:1.10.10.10 98 146 1.9E-7 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS18355 5a39632025cbfd2ddd0a09d57f4230c3 163 Pfam PF02537 CrcB-like protein, Camphor Resistance (CrcB) 25 135 2.0E-19 T 09-03-2017 IPR003691 Putative fluoride ion transporter CrcB GO:0016021 TK78_RS18355 5a39632025cbfd2ddd0a09d57f4230c3 163 Hamap MF_00454 Putative fluoride ion transporter CrcB [crcB]. 23 141 17.385 T 09-03-2017 IPR003691 Putative fluoride ion transporter CrcB GO:0016021 TK78_RS03965 435a6faf2501ee25a9b437e09778e25d 319 Pfam PF08545 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III 107 171 7.1E-26 T 09-03-2017 IPR013751 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 TK78_RS03965 435a6faf2501ee25a9b437e09778e25d 319 SUPERFAMILY SSF53901 4 318 8.93E-57 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS03965 435a6faf2501ee25a9b437e09778e25d 319 Pfam PF08541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal 229 317 2.5E-26 T 09-03-2017 IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, C-terminal KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 TK78_RS03965 435a6faf2501ee25a9b437e09778e25d 319 Gene3D G3DSA:3.40.47.10 1 160 1.6E-57 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS03965 435a6faf2501ee25a9b437e09778e25d 319 Hamap MF_01815 3-oxoacyl-[acyl-carrier-protein] synthase 3 [fabH]. 2 318 57.35 T 09-03-2017 IPR004655 3-oxoacyl-[acyl-carrier-protein] synthase 3 GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 TK78_RS03965 435a6faf2501ee25a9b437e09778e25d 319 Gene3D G3DSA:3.40.47.10 161 318 7.8E-39 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS20360 a33bd58715231f98549cd59e9ef659e8 640 Gene3D G3DSA:3.40.50.980 375 437 4.3E-27 T 09-03-2017 TK78_RS20360 a33bd58715231f98549cd59e9ef659e8 640 Gene3D G3DSA:3.40.50.980 220 319 4.3E-27 T 09-03-2017 TK78_RS20360 a33bd58715231f98549cd59e9ef659e8 640 SUPERFAMILY SSF56801 47 324 2.75E-108 T 09-03-2017 TK78_RS20360 a33bd58715231f98549cd59e9ef659e8 640 SUPERFAMILY SSF56801 378 638 2.75E-108 T 09-03-2017 TK78_RS20360 a33bd58715231f98549cd59e9ef659e8 640 Pfam PF00501 AMP-binding enzyme 55 509 1.7E-89 T 09-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 TK78_RS20360 a33bd58715231f98549cd59e9ef659e8 640 Gene3D G3DSA:2.30.38.10 438 503 1.4E-15 T 09-03-2017 TK78_RS20360 a33bd58715231f98549cd59e9ef659e8 640 ProSitePatterns PS00455 Putative AMP-binding domain signature. 214 225 - T 09-03-2017 IPR020845 AMP-binding, conserved site TK78_RS20360 a33bd58715231f98549cd59e9ef659e8 640 Gene3D G3DSA:3.40.50.980 55 219 1.5E-30 T 09-03-2017 TK78_RS20360 a33bd58715231f98549cd59e9ef659e8 640 Gene3D G3DSA:3.30.300.30 507 627 1.1E-6 T 09-03-2017 TK78_RS29620 42db59d5337197bf18da941ef5b09c93 176 SUPERFAMILY SSF55811 2 174 4.33E-38 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS29620 42db59d5337197bf18da941ef5b09c93 176 ProSitePatterns PS00893 Nudix box signature. 74 95 - T 09-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 TK78_RS29620 42db59d5337197bf18da941ef5b09c93 176 Gene3D G3DSA:3.90.79.10 2 173 1.1E-36 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS29620 42db59d5337197bf18da941ef5b09c93 176 Pfam PF00293 NUDIX domain 40 154 1.2E-17 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS22005 6e0abc2eb8b0692a3ea873148f89c7dc 378 Pfam PF10432 Bacterial phospho-glucose isomerase C-terminal SIS domain 227 373 1.1E-19 T 09-03-2017 IPR019490 Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase, C-terminal GO:0004347|GO:0004476|GO:0005975 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00051+5.3.1.8|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.8+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882 TK78_RS22005 6e0abc2eb8b0692a3ea873148f89c7dc 378 Gene3D G3DSA:3.40.50.10490 226 373 5.8E-6 T 09-03-2017 TK78_RS22005 6e0abc2eb8b0692a3ea873148f89c7dc 378 SUPERFAMILY SSF53697 91 374 1.97E-44 T 09-03-2017 TK78_RS11405 6cef1bd64e909636c59ea4db7e0a39d1 470 Pfam PF07690 Major Facilitator Superfamily 34 364 1.7E-15 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS11405 6cef1bd64e909636c59ea4db7e0a39d1 470 SUPERFAMILY SSF103473 27 430 1.31E-30 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS11405 6cef1bd64e909636c59ea4db7e0a39d1 470 Gene3D G3DSA:1.20.1250.20 21 208 6.4E-16 T 09-03-2017 TK78_RS11405 6cef1bd64e909636c59ea4db7e0a39d1 470 Gene3D G3DSA:1.20.1250.20 247 425 1.1E-8 T 09-03-2017 TK78_RS20515 1f311fb694c53413191c891682b86e06 133 Pfam PF13586 Transposase DDE domain 38 133 1.5E-18 T 09-03-2017 IPR025668 Transposase DDE domain TK78_RS16050 51ae0ddbc068d44f8f472840e6528a5a 133 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 9 96 1.8E-10 T 09-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS16050 51ae0ddbc068d44f8f472840e6528a5a 133 Gene3D G3DSA:2.30.110.10 8 131 2.2E-33 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS16050 51ae0ddbc068d44f8f472840e6528a5a 133 SUPERFAMILY SSF50475 9 131 4.64E-28 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS16050 51ae0ddbc068d44f8f472840e6528a5a 133 TIGRFAM TIGR03618 Rv1155_F420: PPOX class probable F420-dependent enzyme 12 130 4.4E-23 T 09-03-2017 IPR019920 F420-binding domain, putative TK78_RS19720 1e26950632cdcc87e7188baca967afee 400 Gene3D G3DSA:3.30.565.10 272 398 1.5E-7 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS19720 1e26950632cdcc87e7188baca967afee 400 SUPERFAMILY SSF55874 271 396 4.59E-18 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS19720 1e26950632cdcc87e7188baca967afee 400 Pfam PF07730 Histidine kinase 189 254 6.9E-21 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS08795 e9fd355de23b6c6f90d70e4e2ab24990 318 Gene3D G3DSA:3.20.20.100 1 310 8.4E-107 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS08795 e9fd355de23b6c6f90d70e4e2ab24990 318 SUPERFAMILY SSF51430 1 310 1.27E-84 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS08795 e9fd355de23b6c6f90d70e4e2ab24990 318 PRINTS PR00069 Aldo-keto reductase signature 32 56 8.6E-5 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS08795 e9fd355de23b6c6f90d70e4e2ab24990 318 PRINTS PR00069 Aldo-keto reductase signature 96 114 8.6E-5 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS08795 e9fd355de23b6c6f90d70e4e2ab24990 318 PRINTS PR00069 Aldo-keto reductase signature 127 144 8.6E-5 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS08795 e9fd355de23b6c6f90d70e4e2ab24990 318 Pfam PF00248 Aldo/keto reductase family 4 310 2.3E-59 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS24805 7c0382da305ccb2f9cc759bde635d669 382 Gene3D G3DSA:3.40.1190.20 23 339 6.7E-51 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS24805 7c0382da305ccb2f9cc759bde635d669 382 Pfam PF00294 pfkB family carbohydrate kinase 209 329 1.5E-22 T 09-03-2017 IPR011611 Carbohydrate kinase PfkB TK78_RS24805 7c0382da305ccb2f9cc759bde635d669 382 Pfam PF00294 pfkB family carbohydrate kinase 51 132 1.4E-8 T 09-03-2017 IPR011611 Carbohydrate kinase PfkB TK78_RS24805 7c0382da305ccb2f9cc759bde635d669 382 ProSitePatterns PS00584 pfkB family of carbohydrate kinases signature 2. 282 295 - T 09-03-2017 IPR002173 Carbohydrate/puine kinase, PfkB, conserved site GO:0016773 TK78_RS24805 7c0382da305ccb2f9cc759bde635d669 382 SUPERFAMILY SSF53613 23 338 2.65E-46 T 09-03-2017 IPR029056 Ribokinase-like TK78_RS22410 30eee623fc9536a18758a8d03e595334 532 Pfam PF01799 [2Fe-2S] binding domain 413 485 3.4E-22 T 09-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 TK78_RS22410 30eee623fc9536a18758a8d03e595334 532 Gene3D G3DSA:3.10.20.30 343 414 1.0E-24 T 09-03-2017 IPR012675 Beta-grasp domain TK78_RS22410 30eee623fc9536a18758a8d03e595334 532 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 379 387 - T 09-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 TK78_RS22410 30eee623fc9536a18758a8d03e595334 532 Gene3D G3DSA:1.10.150.120 415 507 5.5E-29 T 09-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 TK78_RS22410 30eee623fc9536a18758a8d03e595334 532 SUPERFAMILY SSF54292 341 417 9.83E-18 T 09-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 TK78_RS22410 30eee623fc9536a18758a8d03e595334 532 SUPERFAMILY SSF47741 424 496 9.55E-26 T 09-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 TK78_RS22945 ccfd33c5e99e568d224f88d2e8d36454 175 Pfam PF03703 Bacterial PH domain 85 162 3.5E-15 T 09-03-2017 IPR005182 Domain of unknown function DUF304 TK78_RS21945 b78c8847d514c01084469e757d648fca 363 Gene3D G3DSA:2.160.10.10 262 351 5.7E-17 T 09-03-2017 TK78_RS21945 b78c8847d514c01084469e757d648fca 363 Gene3D G3DSA:3.90.550.10 6 241 7.0E-63 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS21945 b78c8847d514c01084469e757d648fca 363 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 274 307 7.7E-4 T 09-03-2017 IPR001451 Hexapeptide repeat TK78_RS21945 b78c8847d514c01084469e757d648fca 363 SUPERFAMILY SSF53448 282 331 1.98E-66 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS21945 b78c8847d514c01084469e757d648fca 363 SUPERFAMILY SSF53448 7 245 1.98E-66 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS21945 b78c8847d514c01084469e757d648fca 363 Pfam PF00483 Nucleotidyl transferase 7 239 1.3E-43 T 09-03-2017 IPR005835 Nucleotidyl transferase domain GO:0009058|GO:0016779 TK78_RS20735 ec82af756d6f6074761d3c88384be07d 1126 Pfam PF04465 Protein of unknown function (DUF499) 300 837 5.7E-35 T 09-03-2017 IPR007555 Protein of unknown function DUF499 TK78_RS33395 ddb4f52ac24529887b943818228cbaf9 247 SUPERFAMILY SSF55729 111 234 3.72E-21 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS33395 ddb4f52ac24529887b943818228cbaf9 247 Pfam PF08445 FR47-like protein 146 232 1.9E-26 T 09-03-2017 IPR013653 FR47-like GO:0016747 TK78_RS33395 ddb4f52ac24529887b943818228cbaf9 247 Gene3D G3DSA:3.40.630.30 117 233 2.9E-17 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS34520 e6d15b509844ae99fce9075f05aa1c76 379 Gene3D G3DSA:2.120.10.30 31 378 2.1E-96 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS34520 e6d15b509844ae99fce9075f05aa1c76 379 Pfam PF07995 Glucose / Sorbosone dehydrogenase 53 369 2.7E-45 T 09-03-2017 IPR012938 Glucose/Sorbosone dehydrogenase GO:0005975|GO:0016901|GO:0048038 TK78_RS34520 e6d15b509844ae99fce9075f05aa1c76 379 SUPERFAMILY SSF50952 49 371 4.97E-30 T 09-03-2017 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 TK78_RS26785 11e718ab9613d41c39dde84b87dae0e2 269 Gene3D G3DSA:1.10.760.10 142 224 7.6E-21 T 09-03-2017 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 Reactome: R-HSA-611105 TK78_RS26785 11e718ab9613d41c39dde84b87dae0e2 269 Gene3D G3DSA:1.10.760.10 48 133 1.5E-17 T 09-03-2017 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 Reactome: R-HSA-611105 TK78_RS26785 11e718ab9613d41c39dde84b87dae0e2 269 SUPERFAMILY SSF46626 15 129 6.16E-18 T 09-03-2017 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 Reactome: R-HSA-611105 TK78_RS26785 11e718ab9613d41c39dde84b87dae0e2 269 SUPERFAMILY SSF46626 125 218 2.33E-26 T 09-03-2017 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 Reactome: R-HSA-611105 TK78_RS26785 11e718ab9613d41c39dde84b87dae0e2 269 PIRSF PIRSF000007 1 263 6.1E-126 T 09-03-2017 IPR009152 Ubiquinol-cytochrome-c reductase, cytochrome c subunit GO:0005506|GO:0009055|GO:0016021|GO:0020037 TK78_RS26785 11e718ab9613d41c39dde84b87dae0e2 269 Pfam PF00034 Cytochrome c 50 125 3.9E-8 T 09-03-2017 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 Reactome: R-HSA-611105 TK78_RS26785 11e718ab9613d41c39dde84b87dae0e2 269 Pfam PF13442 Cytochrome C oxidase, cbb3-type, subunit III 142 216 3.4E-13 T 09-03-2017 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 Reactome: R-HSA-611105 TK78_RS16635 e759d48941be1abd33083679db9d9a86 526 Gene3D G3DSA:1.20.1250.20 468 502 7.9E-17 T 09-03-2017 TK78_RS16635 e759d48941be1abd33083679db9d9a86 526 Gene3D G3DSA:1.20.1250.20 265 431 7.9E-17 T 09-03-2017 TK78_RS16635 e759d48941be1abd33083679db9d9a86 526 Pfam PF07690 Major Facilitator Superfamily 26 420 1.3E-51 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS16635 e759d48941be1abd33083679db9d9a86 526 Gene3D G3DSA:1.20.1250.20 17 206 1.3E-33 T 09-03-2017 TK78_RS16635 e759d48941be1abd33083679db9d9a86 526 PRINTS PR01036 Tetracycline resistance protein TetB signature 146 170 6.9E-12 T 09-03-2017 TK78_RS16635 e759d48941be1abd33083679db9d9a86 526 PRINTS PR01036 Tetracycline resistance protein TetB signature 85 107 6.9E-12 T 09-03-2017 TK78_RS16635 e759d48941be1abd33083679db9d9a86 526 PRINTS PR01036 Tetracycline resistance protein TetB signature 411 430 6.9E-12 T 09-03-2017 TK78_RS16635 e759d48941be1abd33083679db9d9a86 526 PRINTS PR01036 Tetracycline resistance protein TetB signature 25 49 6.9E-12 T 09-03-2017 TK78_RS16635 e759d48941be1abd33083679db9d9a86 526 SUPERFAMILY SSF103473 256 430 2.62E-63 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS16635 e759d48941be1abd33083679db9d9a86 526 SUPERFAMILY SSF103473 12 208 2.62E-63 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS16635 e759d48941be1abd33083679db9d9a86 526 SUPERFAMILY SSF103473 467 497 2.62E-63 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS12150 955508f120e9cea941310106dfc90e12 124 Pfam PF13466 STAS domain 20 106 8.6E-20 T 09-03-2017 IPR002645 STAS domain TK78_RS12150 955508f120e9cea941310106dfc90e12 124 Gene3D G3DSA:3.30.750.24 18 118 7.5E-6 T 09-03-2017 IPR002645 STAS domain TK78_RS12150 955508f120e9cea941310106dfc90e12 124 SUPERFAMILY SSF52091 16 111 6.87E-7 T 09-03-2017 IPR002645 STAS domain TK78_RS21320 4c9e06ad778d32d20a03ddaea6a04c0c 200 Pfam PF05685 Putative restriction endonuclease 25 189 6.8E-25 T 09-03-2017 IPR008538 Domain of unknown function DUF820 TK78_RS21320 4c9e06ad778d32d20a03ddaea6a04c0c 200 SUPERFAMILY SSF52980 14 151 3.75E-18 T 09-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 TK78_RS21320 4c9e06ad778d32d20a03ddaea6a04c0c 200 Gene3D G3DSA:3.90.1570.10 15 151 8.3E-17 T 09-03-2017 IPR012296 Nuclease, putative, TT1808 TK78_RS17120 2770fc2af4cbb060bb9ce781278ee343 145 Pfam PF04686 Streptomyces sporulation and cell division protein, SsgA 23 120 1.6E-30 T 09-03-2017 IPR006776 Sporulation-specific cell division protein SsgB GO:0051301 TK78_RS29850 74f6b04e1e18629c1d78bfbd87b9054f 721 Gene3D G3DSA:3.40.50.300 507 605 6.0E-26 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29850 74f6b04e1e18629c1d78bfbd87b9054f 721 Gene3D G3DSA:3.40.50.300 189 298 6.0E-26 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29850 74f6b04e1e18629c1d78bfbd87b9054f 721 Pfam PF13245 Part of AAA domain 201 280 1.1E-12 T 09-03-2017 TK78_RS29850 74f6b04e1e18629c1d78bfbd87b9054f 721 SUPERFAMILY SSF52540 503 718 2.0E-37 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29850 74f6b04e1e18629c1d78bfbd87b9054f 721 SUPERFAMILY SSF52540 188 268 2.0E-37 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29850 74f6b04e1e18629c1d78bfbd87b9054f 721 Gene3D G3DSA:3.40.50.300 655 718 5.7E-10 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15840 2b01e97a2c87076086338280dfb15a97 278 Gene3D G3DSA:1.10.260.40 14 74 8.7E-7 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS15840 2b01e97a2c87076086338280dfb15a97 278 SUPERFAMILY SSF47413 14 72 1.84E-5 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS22200 62ff836f0a2ee993bd309d86800e47f3 954 SUPERFAMILY SSF53756 689 933 7.85E-19 T 09-03-2017 TK78_RS22200 62ff836f0a2ee993bd309d86800e47f3 954 SUPERFAMILY SSF53448 20 225 2.93E-14 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS22200 62ff836f0a2ee993bd309d86800e47f3 954 Pfam PF04464 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase 567 934 4.0E-95 T 09-03-2017 IPR007554 CDP-glycerol glycerophosphotransferase GO:0016020|GO:0047355 TK78_RS22200 62ff836f0a2ee993bd309d86800e47f3 954 Gene3D G3DSA:3.90.550.10 20 213 1.1E-13 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS03090 735538f79f96e4777cd0e3f8662a5e10 276 Pfam PF00884 Sulfatase 9 243 1.4E-9 T 09-03-2017 IPR000917 Sulfatase, N-terminal GO:0008152|GO:0008484 TK78_RS03090 735538f79f96e4777cd0e3f8662a5e10 276 Gene3D G3DSA:3.40.720.10 10 243 3.9E-13 T 09-03-2017 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 TK78_RS03090 735538f79f96e4777cd0e3f8662a5e10 276 SUPERFAMILY SSF53649 10 259 8.58E-21 T 09-03-2017 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 TK78_RS34440 ca1e174c49569ca305cb7ba26dd896f2 371 Pfam PF01594 Domain of unknown function DUF20 26 345 2.1E-59 T 09-03-2017 IPR002549 Transmembrane protein TqsA-like TK78_RS34735 b441b556f8be7e58378876da05422ba7 139 Pfam PF04237 YjbR 21 121 2.4E-7 T 09-03-2017 IPR007351 Uncharacterised protein YjbR TK78_RS34735 b441b556f8be7e58378876da05422ba7 139 SUPERFAMILY SSF142906 13 133 2.49E-5 T 09-03-2017 TK78_RS33220 74292b3993fe3616a16fc9a49a7709c1 344 Pfam PF01497 Periplasmic binding protein 60 310 2.6E-35 T 09-03-2017 IPR002491 ABC transporter periplasmic binding domain GO:0005488 TK78_RS33220 74292b3993fe3616a16fc9a49a7709c1 344 Gene3D G3DSA:3.40.50.1980 170 336 5.0E-18 T 09-03-2017 TK78_RS33220 74292b3993fe3616a16fc9a49a7709c1 344 Gene3D G3DSA:3.40.50.1980 40 169 8.8E-24 T 09-03-2017 TK78_RS33220 74292b3993fe3616a16fc9a49a7709c1 344 SUPERFAMILY SSF53807 38 311 1.06E-49 T 09-03-2017 TK78_RS03885 62a76d9b3ac6ce7a2cf254e90af0ffcc 434 Pfam PF10011 Predicted membrane protein (DUF2254) 20 387 1.5E-97 T 09-03-2017 IPR018723 Protein of unknown function DUF2254, membrane TK78_RS06330 d2a7358b41c3923ce3ea43dbf8cd37fb 149 Pfam PF01467 Cytidylyltransferase-like 8 134 1.9E-13 T 09-03-2017 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 TK78_RS06330 d2a7358b41c3923ce3ea43dbf8cd37fb 149 TIGRFAM TIGR00125 cyt_tran_rel: cytidyltransferase-like domain 6 70 2.1E-16 T 09-03-2017 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 TK78_RS06330 d2a7358b41c3923ce3ea43dbf8cd37fb 149 SUPERFAMILY SSF52374 5 136 3.56E-23 T 09-03-2017 TK78_RS06330 d2a7358b41c3923ce3ea43dbf8cd37fb 149 Gene3D G3DSA:3.40.50.620 5 124 8.2E-29 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS28115 8cd030cedb1af7d477585a25d81b2e7a 433 Pfam PF07730 Histidine kinase 215 279 7.4E-18 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS28115 8cd030cedb1af7d477585a25d81b2e7a 433 SUPERFAMILY SSF55874 319 418 1.76E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS01340 42dc6359fb65aa6144663f925b85cbd1 564 SUPERFAMILY SSF103473 471 495 1.7E-71 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS01340 42dc6359fb65aa6144663f925b85cbd1 564 SUPERFAMILY SSF103473 257 429 1.7E-71 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS01340 42dc6359fb65aa6144663f925b85cbd1 564 SUPERFAMILY SSF103473 13 207 1.7E-71 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS01340 42dc6359fb65aa6144663f925b85cbd1 564 Pfam PF07690 Major Facilitator Superfamily 28 419 2.8E-55 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS01340 42dc6359fb65aa6144663f925b85cbd1 564 Gene3D G3DSA:1.20.1250.20 22 204 1.4E-29 T 09-03-2017 TK78_RS01340 42dc6359fb65aa6144663f925b85cbd1 564 Gene3D G3DSA:1.20.1250.20 472 496 1.5E-20 T 09-03-2017 TK78_RS01340 42dc6359fb65aa6144663f925b85cbd1 564 Gene3D G3DSA:1.20.1250.20 272 429 1.5E-20 T 09-03-2017 TK78_RS01340 42dc6359fb65aa6144663f925b85cbd1 564 PRINTS PR01036 Tetracycline resistance protein TetB signature 148 172 3.9E-6 T 09-03-2017 TK78_RS01340 42dc6359fb65aa6144663f925b85cbd1 564 PRINTS PR01036 Tetracycline resistance protein TetB signature 86 108 3.9E-6 T 09-03-2017 TK78_RS01340 42dc6359fb65aa6144663f925b85cbd1 564 PRINTS PR01036 Tetracycline resistance protein TetB signature 26 50 3.9E-6 T 09-03-2017 TK78_RS13790 bb92556c5d50971996db3605d69ce5c8 382 PIRSF PIRSF000429 3 379 6.0E-20 T 09-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 TK78_RS13790 bb92556c5d50971996db3605d69ce5c8 382 SUPERFAMILY SSF53901 9 228 1.05E-15 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS13790 bb92556c5d50971996db3605d69ce5c8 382 Gene3D G3DSA:3.40.47.10 12 114 3.2E-9 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS13790 bb92556c5d50971996db3605d69ce5c8 382 Gene3D G3DSA:3.40.47.10 198 225 3.2E-9 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS13790 bb92556c5d50971996db3605d69ce5c8 382 SUPERFAMILY SSF53901 251 370 1.26E-13 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS13790 bb92556c5d50971996db3605d69ce5c8 382 Gene3D G3DSA:3.40.47.10 246 334 1.1E-5 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS13790 bb92556c5d50971996db3605d69ce5c8 382 Gene3D G3DSA:3.40.47.10 145 182 1.1E-5 T 09-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 TK78_RS13995 364a2bb52cc4dbd9c54b6c9ac6de2c99 399 SUPERFAMILY SSF51556 8 37 6.12E-75 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS13995 364a2bb52cc4dbd9c54b6c9ac6de2c99 399 SUPERFAMILY SSF51556 87 398 6.12E-75 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS13995 364a2bb52cc4dbd9c54b6c9ac6de2c99 399 Gene3D G3DSA:3.20.20.140 9 36 7.1E-70 T 09-03-2017 TK78_RS13995 364a2bb52cc4dbd9c54b6c9ac6de2c99 399 Gene3D G3DSA:3.20.20.140 84 396 7.1E-70 T 09-03-2017 TK78_RS13995 364a2bb52cc4dbd9c54b6c9ac6de2c99 399 Pfam PF04909 Amidohydrolase 96 395 1.1E-46 T 09-03-2017 IPR006680 Amidohydrolase-related GO:0016787 TK78_RS11940 234a6aee52c24ae158bde74775c86805 422 SUPERFAMILY SSF141523 261 392 2.35E-23 T 09-03-2017 TK78_RS11940 234a6aee52c24ae158bde74775c86805 422 Gene3D G3DSA:2.40.440.10 261 393 3.3E-20 T 09-03-2017 TK78_RS11940 234a6aee52c24ae158bde74775c86805 422 Pfam PF03734 L,D-transpeptidase catalytic domain 259 392 1.0E-13 T 09-03-2017 IPR005490 L,D-transpeptidase catalytic domain GO:0016740 TK78_RS05025 c099663c977e8778ac05d1336775de2f 330 SUPERFAMILY SSF161098 86 316 5.23E-53 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS05025 c099663c977e8778ac05d1336775de2f 330 Gene3D G3DSA:1.10.3720.10 35 319 1.6E-55 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS05025 c099663c977e8778ac05d1336775de2f 330 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 121 321 1.1E-11 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS18325 3bb0f6f9c6422534d8f7b58d4338cc03 293 Pfam PF02683 Cytochrome C biogenesis protein transmembrane region 10 180 9.3E-22 T 09-03-2017 IPR003834 Cytochrome C biogenesis protein, transmembrane domain GO:0016020|GO:0017004|GO:0055114 TK78_RS28560 174976df0e3df787813765fbb3b6f2fe 256 SUPERFAMILY SSF48452 43 97 1.05E-9 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS28560 174976df0e3df787813765fbb3b6f2fe 256 SUPERFAMILY SSF48452 134 204 1.05E-9 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS28560 174976df0e3df787813765fbb3b6f2fe 256 Pfam PF14559 Tetratricopeptide repeat 146 204 3.7E-7 T 09-03-2017 TK78_RS28560 174976df0e3df787813765fbb3b6f2fe 256 Gene3D G3DSA:1.25.40.10 45 204 8.1E-10 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS31395 c5f9faa5b912bae2afd62c79e704deec 138 SMART SM00881 12 105 1.1E-21 T 09-03-2017 IPR003781 CoA-binding GO:0048037 TK78_RS31395 c5f9faa5b912bae2afd62c79e704deec 138 SUPERFAMILY SSF51735 17 135 1.67E-37 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31395 c5f9faa5b912bae2afd62c79e704deec 138 Gene3D G3DSA:3.40.50.720 5 135 4.7E-42 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31395 c5f9faa5b912bae2afd62c79e704deec 138 Pfam PF13380 CoA binding domain 18 131 9.9E-37 T 09-03-2017 IPR003781 CoA-binding GO:0048037 TK78_RS32640 e1810a3ec60c220dcbabdcefe4f3238f 228 Pfam PF03713 Domain of unknown function (DUF305) 85 227 1.3E-47 T 09-03-2017 IPR005183 Domain of unknown function DUF305 TK78_RS32640 e1810a3ec60c220dcbabdcefe4f3238f 228 Gene3D G3DSA:1.20.1260.10 80 228 5.8E-52 T 09-03-2017 IPR012347 Ferritin-related TK78_RS21450 78cdb24f09c4d55507f39526decee12c 129 Gene3D G3DSA:3.10.180.10 1 127 7.7E-24 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS21450 78cdb24f09c4d55507f39526decee12c 129 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 3 125 6.5E-15 T 09-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain TK78_RS21450 78cdb24f09c4d55507f39526decee12c 129 SUPERFAMILY SSF54593 1 127 7.52E-27 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS32455 ab7d797d9e090ffd771defc2aa7f4036 239 Gene3D G3DSA:3.40.50.150 25 155 1.4E-26 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS32455 ab7d797d9e090ffd771defc2aa7f4036 239 SUPERFAMILY SSF53335 10 176 5.42E-29 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS32455 ab7d797d9e090ffd771defc2aa7f4036 239 Pfam PF08241 Methyltransferase domain 50 137 2.4E-15 T 09-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 TK78_RS24350 248afb9b3ff77176cddfd6a785a0816c 477 Pfam PF00324 Amino acid permease 34 463 5.2E-117 T 09-03-2017 IPR004841 Amino acid permease/ SLC12A domain GO:0006810|GO:0016020|GO:0055085 TK78_RS24350 248afb9b3ff77176cddfd6a785a0816c 477 PIRSF PIRSF006060 11 474 5.0E-74 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS24350 248afb9b3ff77176cddfd6a785a0816c 477 ProSitePatterns PS00218 Amino acid permeases signature. 59 89 - T 09-03-2017 IPR004840 Amino acid permease, conserved site GO:0006865|GO:0016021|GO:0055085 TK78_RS00430 eed61bce0af74ac470c0e95c6bc632f3 298 Pfam PF00005 ABC transporter 33 182 1.6E-31 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS00430 eed61bce0af74ac470c0e95c6bc632f3 298 SMART SM00382 42 230 2.4E-11 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS00430 eed61bce0af74ac470c0e95c6bc632f3 298 SUPERFAMILY SSF52540 16 239 1.28E-57 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS00430 eed61bce0af74ac470c0e95c6bc632f3 298 Gene3D G3DSA:3.40.50.300 9 240 1.9E-62 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22600 b66a023104eb22ade1aba4e4e0e93f5c 140 Gene3D G3DSA:3.40.140.10 1 136 1.1E-34 T 09-03-2017 TK78_RS22600 b66a023104eb22ade1aba4e4e0e93f5c 140 SMART SM00232 1 134 4.2E-27 T 09-03-2017 IPR000555 JAB1/MPN/MOV34 metalloenzyme domain GO:0005515 TK78_RS22600 b66a023104eb22ade1aba4e4e0e93f5c 140 SUPERFAMILY SSF102712 1 132 5.62E-27 T 09-03-2017 TK78_RS22600 b66a023104eb22ade1aba4e4e0e93f5c 140 Pfam PF14464 Prokaryotic homologs of the JAB domain 6 110 3.5E-26 T 09-03-2017 IPR028090 JAB domain, prokaryotic TK78_RS24050 ecc306e188805526d9ae8a9a419d0305 153 SUPERFAMILY SSF50249 5 120 9.6E-23 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS24050 ecc306e188805526d9ae8a9a419d0305 153 Pfam PF00436 Single-strand binding protein family 6 103 2.0E-15 T 09-03-2017 IPR000424 Primosome PriB/single-strand DNA-binding GO:0003697 Reactome: R-HSA-2151201 TK78_RS24050 ecc306e188805526d9ae8a9a419d0305 153 PIRSF PIRSF002070 1 152 2.8E-20 T 09-03-2017 IPR011344 Single-stranded DNA-binding protein GO:0003697|GO:0006260 Reactome: R-HSA-2151201 TK78_RS24050 ecc306e188805526d9ae8a9a419d0305 153 Gene3D G3DSA:2.40.50.140 3 116 9.6E-28 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS04720 fa44c3ab96ad3c57d94a12d4ff1c96cd 605 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 414 432 5.6E-66 T 09-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 TK78_RS04720 fa44c3ab96ad3c57d94a12d4ff1c96cd 605 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 146 164 5.6E-66 T 09-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 TK78_RS04720 fa44c3ab96ad3c57d94a12d4ff1c96cd 605 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 273 289 5.6E-66 T 09-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 TK78_RS04720 fa44c3ab96ad3c57d94a12d4ff1c96cd 605 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 303 322 5.6E-66 T 09-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 TK78_RS04720 fa44c3ab96ad3c57d94a12d4ff1c96cd 605 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 164 183 5.6E-66 T 09-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 TK78_RS04720 fa44c3ab96ad3c57d94a12d4ff1c96cd 605 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 474 489 5.6E-66 T 09-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 TK78_RS04720 fa44c3ab96ad3c57d94a12d4ff1c96cd 605 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 498 515 5.6E-66 T 09-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 TK78_RS04720 fa44c3ab96ad3c57d94a12d4ff1c96cd 605 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 72 97 5.6E-66 T 09-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 TK78_RS04720 fa44c3ab96ad3c57d94a12d4ff1c96cd 605 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 438 456 5.6E-66 T 09-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 TK78_RS04720 fa44c3ab96ad3c57d94a12d4ff1c96cd 605 SUPERFAMILY SSF56235 42 595 3.32E-156 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS04720 fa44c3ab96ad3c57d94a12d4ff1c96cd 605 Pfam PF01019 Gamma-glutamyltranspeptidase 65 591 7.5E-152 T 09-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 TK78_RS04720 fa44c3ab96ad3c57d94a12d4ff1c96cd 605 TIGRFAM TIGR00066 g_glut_trans: gamma-glutamyltransferase 52 585 3.4E-118 T 09-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 TK78_RS27565 1842622fd23331c2a920acbaad79ac06 476 Gene3D G3DSA:3.90.1150.10 350 457 2.7E-35 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS27565 1842622fd23331c2a920acbaad79ac06 476 Pfam PF00282 Pyridoxal-dependent decarboxylase conserved domain 74 395 6.2E-43 T 09-03-2017 IPR002129 Pyridoxal phosphate-dependent decarboxylase GO:0016831|GO:0019752|GO:0030170 TK78_RS27565 1842622fd23331c2a920acbaad79ac06 476 Gene3D G3DSA:3.40.640.10 96 349 4.3E-73 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS27565 1842622fd23331c2a920acbaad79ac06 476 SUPERFAMILY SSF53383 58 451 2.26E-95 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS33500 0da064c6ef8cc37f2b37c58568bd40d5 146 Pfam PF00358 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 6 47 1.0E-7 T 09-03-2017 IPR001127 Phosphotransferase system, sugar-specific permease EIIA type 1 GO:0009401 TK78_RS33500 0da064c6ef8cc37f2b37c58568bd40d5 146 SUPERFAMILY SSF51261 5 47 6.1E-9 T 09-03-2017 IPR011055 Duplicated hybrid motif TK78_RS33500 0da064c6ef8cc37f2b37c58568bd40d5 146 Gene3D G3DSA:2.70.70.10 5 47 1.1E-9 T 09-03-2017 TK78_RS09465 ac3cfd97f0a92558ea62b2980ec42648 327 Pfam PF12840 Helix-turn-helix domain 261 307 3.7E-8 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS09465 ac3cfd97f0a92558ea62b2980ec42648 327 SUPERFAMILY SSF46785 249 324 1.68E-12 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS09465 ac3cfd97f0a92558ea62b2980ec42648 327 SMART SM00418 253 327 0.0033 T 09-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TK78_RS09465 ac3cfd97f0a92558ea62b2980ec42648 327 Gene3D G3DSA:1.10.10.10 260 321 2.1E-12 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS16490 2720040cc47ccccb7d08df36c6dc54f3 136 Pfam PF03795 YCII-related domain 1 111 2.4E-16 T 09-03-2017 IPR005545 YCII-related TK78_RS16490 2720040cc47ccccb7d08df36c6dc54f3 136 SUPERFAMILY SSF54909 27 112 1.13E-19 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS16490 2720040cc47ccccb7d08df36c6dc54f3 136 Gene3D G3DSA:3.30.70.1060 1 130 9.5E-32 T 09-03-2017 TK78_RS01880 fdebe426f526da57ff0523481957a445 345 Gene3D G3DSA:2.115.10.20 92 165 4.3E-6 T 09-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain TK78_RS01880 fdebe426f526da57ff0523481957a445 345 SUPERFAMILY SSF75005 55 286 8.74E-20 T 09-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain TK78_RS01880 fdebe426f526da57ff0523481957a445 345 Gene3D G3DSA:2.115.10.20 167 344 3.4E-8 T 09-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain TK78_RS17515 e4a11bf3c285d51ce019cee20bc23db7 485 Pfam PF00905 Penicillin binding protein transpeptidase domain 156 478 1.4E-69 T 09-03-2017 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 TK78_RS17515 e4a11bf3c285d51ce019cee20bc23db7 485 Gene3D G3DSA:3.40.710.10 138 484 1.0E-91 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS17515 e4a11bf3c285d51ce019cee20bc23db7 485 SUPERFAMILY SSF56601 139 482 8.2E-84 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS17165 64f86719d9998c2235d899a52964ced4 403 Gene3D G3DSA:1.20.1250.20 5 186 1.4E-26 T 09-03-2017 TK78_RS17165 64f86719d9998c2235d899a52964ced4 403 Gene3D G3DSA:1.20.1250.20 197 373 1.2E-12 T 09-03-2017 TK78_RS17165 64f86719d9998c2235d899a52964ced4 403 SUPERFAMILY SSF103473 3 375 3.4E-57 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS17165 64f86719d9998c2235d899a52964ced4 403 Pfam PF07690 Major Facilitator Superfamily 8 310 2.4E-41 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS00365 446a74e6b1207e43c815d0dce5049bb1 301 Gene3D G3DSA:3.40.50.720 149 234 2.4E-10 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS00365 446a74e6b1207e43c815d0dce5049bb1 301 Pfam PF13602 Zinc-binding dehydrogenase 195 299 3.9E-10 T 09-03-2017 TK78_RS00365 446a74e6b1207e43c815d0dce5049bb1 301 Gene3D G3DSA:3.90.180.10 1 148 7.5E-38 T 09-03-2017 IPR011032 GroES-like TK78_RS00365 446a74e6b1207e43c815d0dce5049bb1 301 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 27 88 5.2E-11 T 09-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 TK78_RS00365 446a74e6b1207e43c815d0dce5049bb1 301 SUPERFAMILY SSF50129 1 147 1.67E-31 T 09-03-2017 IPR011032 GroES-like TK78_RS00365 446a74e6b1207e43c815d0dce5049bb1 301 SUPERFAMILY SSF51735 114 297 1.18E-20 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS00365 446a74e6b1207e43c815d0dce5049bb1 301 SMART SM00829 10 299 4.9E-12 T 09-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 TK78_RS13970 c0c184409ebc155adec4b257c598c162 305 SUPERFAMILY SSF51735 5 249 1.53E-54 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS13970 c0c184409ebc155adec4b257c598c162 305 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 208 228 2.4E-23 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS13970 c0c184409ebc155adec4b257c598c162 305 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 186 203 2.4E-23 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS13970 c0c184409ebc155adec4b257c598c162 305 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 9 26 2.4E-23 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS13970 c0c184409ebc155adec4b257c598c162 305 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 92 103 2.4E-23 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS13970 c0c184409ebc155adec4b257c598c162 305 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 165 184 2.4E-23 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS13970 c0c184409ebc155adec4b257c598c162 305 Gene3D G3DSA:3.40.50.720 3 256 5.9E-61 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS13970 c0c184409ebc155adec4b257c598c162 305 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 14 242 6.7E-37 T 09-03-2017 TK78_RS13970 c0c184409ebc155adec4b257c598c162 305 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 8 199 1.3E-4 T 09-03-2017 TK78_RS02415 8fc935139a85a22214b3e92bc98a3cad 202 Gene3D G3DSA:1.10.10.60 4 68 2.2E-20 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS02415 8fc935139a85a22214b3e92bc98a3cad 202 ProSitePatterns PS01081 TetR-type HTH domain signature. 29 59 - T 09-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site TK78_RS02415 8fc935139a85a22214b3e92bc98a3cad 202 SUPERFAMILY SSF46689 3 84 4.99E-14 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS02415 8fc935139a85a22214b3e92bc98a3cad 202 Gene3D G3DSA:1.10.357.10 76 197 1.3E-39 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS02415 8fc935139a85a22214b3e92bc98a3cad 202 SUPERFAMILY SSF48498 83 196 1.99E-23 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS02415 8fc935139a85a22214b3e92bc98a3cad 202 Pfam PF00440 Bacterial regulatory proteins, tetR family 19 63 3.2E-9 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS05710 67b107b71f2783e7a07c7ed1cc92f5aa 418 Pfam PF06772 Bacterial low temperature requirement A protein (LtrA) 17 383 7.4E-50 T 09-03-2017 IPR010640 Low temperature requirement A TK78_RS01665 961af401b2ae13a3b025571d10c9b4bb 429 SUPERFAMILY SSF48264 57 424 6.02E-76 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS01665 961af401b2ae13a3b025571d10c9b4bb 429 Gene3D G3DSA:1.10.630.10 18 425 3.3E-99 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS01665 961af401b2ae13a3b025571d10c9b4bb 429 PRINTS PR00359 B-class P450 signature 300 311 5.0E-40 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS01665 961af401b2ae13a3b025571d10c9b4bb 429 PRINTS PR00359 B-class P450 signature 108 119 5.0E-40 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS01665 961af401b2ae13a3b025571d10c9b4bb 429 PRINTS PR00359 B-class P450 signature 171 186 5.0E-40 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS01665 961af401b2ae13a3b025571d10c9b4bb 429 PRINTS PR00359 B-class P450 signature 345 360 5.0E-40 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS01665 961af401b2ae13a3b025571d10c9b4bb 429 PRINTS PR00359 B-class P450 signature 367 376 5.0E-40 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS01665 961af401b2ae13a3b025571d10c9b4bb 429 PRINTS PR00359 B-class P450 signature 154 170 5.0E-40 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS01665 961af401b2ae13a3b025571d10c9b4bb 429 PRINTS PR00359 B-class P450 signature 218 240 5.0E-40 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS01665 961af401b2ae13a3b025571d10c9b4bb 429 PRINTS PR00359 B-class P450 signature 317 344 5.0E-40 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS01665 961af401b2ae13a3b025571d10c9b4bb 429 PRINTS PR00359 B-class P450 signature 376 387 5.0E-40 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS01665 961af401b2ae13a3b025571d10c9b4bb 429 Pfam PF00067 Cytochrome P450 234 394 1.2E-17 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS17230 e8edae80b43a47a441ecc0101b9a04ea 96 SUPERFAMILY SSF54995 1 94 7.72E-33 T 09-03-2017 IPR000529 Ribosomal protein S6 GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS17230 e8edae80b43a47a441ecc0101b9a04ea 96 Hamap MF_00360 30S ribosomal protein S6 [rpsF]. 1 95 22.306 T 09-03-2017 IPR020814 Ribosomal protein S6, plastid/chloroplast GO:0003735|GO:0005840|GO:0006412|GO:0019843 TK78_RS17230 e8edae80b43a47a441ecc0101b9a04ea 96 Gene3D G3DSA:3.30.70.60 1 94 1.2E-35 T 09-03-2017 IPR014717 Translation elongation factor EF1B/ribosomal protein S6 TK78_RS17230 e8edae80b43a47a441ecc0101b9a04ea 96 Pfam PF01250 Ribosomal protein S6 3 92 2.6E-29 T 09-03-2017 IPR000529 Ribosomal protein S6 GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS17230 e8edae80b43a47a441ecc0101b9a04ea 96 TIGRFAM TIGR00166 S6: ribosomal protein bS6 1 92 7.4E-27 T 09-03-2017 IPR000529 Ribosomal protein S6 GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TK78_RS17230 e8edae80b43a47a441ecc0101b9a04ea 96 ProSitePatterns PS01048 Ribosomal protein S6 signature. 44 53 - T 09-03-2017 IPR020815 Ribosomal protein S6, conserved site GO:0003735|GO:0005840|GO:0006412|GO:0019843 TK78_RS11125 384ce40662fd667075184025d8922eef 280 Gene3D G3DSA:3.40.50.720 3 214 1.4E-28 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS11125 384ce40662fd667075184025d8922eef 280 Pfam PF13460 NAD(P)H-binding 11 181 1.4E-11 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS11125 384ce40662fd667075184025d8922eef 280 SUPERFAMILY SSF51735 6 271 1.52E-43 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS11965 b29ebf234f42aa67e7d87a78bc41e629 270 Gene3D G3DSA:3.90.226.10 19 210 6.5E-65 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS11965 b29ebf234f42aa67e7d87a78bc41e629 270 ProSitePatterns PS00166 Enoyl-CoA hydratase/isomerase signature. 111 131 - T 09-03-2017 IPR018376 Enoyl-CoA hydratase/isomerase, conserved site GO:0003824|GO:0008152 TK78_RS11965 b29ebf234f42aa67e7d87a78bc41e629 270 Gene3D G3DSA:1.10.12.10 211 270 2.7E-17 T 09-03-2017 IPR014748 Crontonase, C-terminal TK78_RS11965 b29ebf234f42aa67e7d87a78bc41e629 270 Pfam PF00378 Enoyl-CoA hydratase/isomerase 20 268 1.9E-58 T 09-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 TK78_RS11965 b29ebf234f42aa67e7d87a78bc41e629 270 SUPERFAMILY SSF52096 17 269 1.22E-79 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS20025 18d2266406036cdc1fb58992141f2cc3 334 Gene3D G3DSA:3.20.20.70 5 330 2.6E-144 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS20025 18d2266406036cdc1fb58992141f2cc3 334 SMART SM01004 7 329 1.8E-218 T 09-03-2017 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS20025 18d2266406036cdc1fb58992141f2cc3 334 Pfam PF00490 Delta-aminolevulinic acid dehydratase 10 328 2.7E-138 T 09-03-2017 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS20025 18d2266406036cdc1fb58992141f2cc3 334 PIRSF PIRSF001415 1 332 9.6E-147 T 09-03-2017 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS20025 18d2266406036cdc1fb58992141f2cc3 334 PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature 128 142 5.6E-55 T 09-03-2017 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS20025 18d2266406036cdc1fb58992141f2cc3 334 PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature 248 264 5.6E-55 T 09-03-2017 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS20025 18d2266406036cdc1fb58992141f2cc3 334 PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature 197 216 5.6E-55 T 09-03-2017 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS20025 18d2266406036cdc1fb58992141f2cc3 334 PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature 303 322 5.6E-55 T 09-03-2017 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS20025 18d2266406036cdc1fb58992141f2cc3 334 PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature 159 178 5.6E-55 T 09-03-2017 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS20025 18d2266406036cdc1fb58992141f2cc3 334 PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature 273 288 5.6E-55 T 09-03-2017 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS20025 18d2266406036cdc1fb58992141f2cc3 334 ProSitePatterns PS00169 Delta-aminolevulinic acid dehydratase active site. 248 260 - T 09-03-2017 IPR030656 Delta-aminolevulinic acid dehydratase, active site KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TK78_RS20025 18d2266406036cdc1fb58992141f2cc3 334 SUPERFAMILY SSF51569 4 330 4.98E-132 T 09-03-2017 TK78_RS15830 f78c1c4153f8ca405efb5a74f275e62e 106 SUPERFAMILY SSF103481 4 104 1.19E-16 T 09-03-2017 TK78_RS15830 f78c1c4153f8ca405efb5a74f275e62e 106 Pfam PF00893 Small Multidrug Resistance protein 1 93 4.8E-18 T 09-03-2017 IPR000390 Small multidrug resistance protein family GO:0016021 TK78_RS28200 547f1f29e87199d378cfb3f0243af52f 358 Gene3D G3DSA:2.30.40.10 43 48 1.5E-7 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS28200 547f1f29e87199d378cfb3f0243af52f 358 Gene3D G3DSA:2.30.40.10 320 357 1.5E-7 T 09-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 TK78_RS28200 547f1f29e87199d378cfb3f0243af52f 358 SUPERFAMILY SSF51556 47 321 2.48E-63 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS28200 547f1f29e87199d378cfb3f0243af52f 358 Gene3D G3DSA:3.20.20.140 49 319 1.1E-64 T 09-03-2017 TK78_RS28200 547f1f29e87199d378cfb3f0243af52f 358 Pfam PF01979 Amidohydrolase family 44 357 2.5E-15 T 09-03-2017 IPR006680 Amidohydrolase-related GO:0016787 TK78_RS33765 ea921ecf30f8cfda8f9d13cb7a7f8516 400 Pfam PF02361 Cobalt transport protein 27 244 2.3E-10 T 09-03-2017 IPR003339 ABC/ECF transporter, transmembrane component TK78_RS18360 08d480fb18939073f23340dde2d3e280 124 TIGRFAM TIGR00494 crcB: protein CrcB 4 118 1.2E-23 T 09-03-2017 IPR003691 Putative fluoride ion transporter CrcB GO:0016021 TK78_RS18360 08d480fb18939073f23340dde2d3e280 124 Hamap MF_00454 Putative fluoride ion transporter CrcB [crcB]. 3 120 18.619 T 09-03-2017 IPR003691 Putative fluoride ion transporter CrcB GO:0016021 TK78_RS18360 08d480fb18939073f23340dde2d3e280 124 Pfam PF02537 CrcB-like protein, Camphor Resistance (CrcB) 4 115 9.0E-24 T 09-03-2017 IPR003691 Putative fluoride ion transporter CrcB GO:0016021 TK78_RS14925 b353e9c5bd4c0d1f39c1def0e4a59541 356 Gene3D G3DSA:3.40.50.360 7 188 3.0E-41 T 09-03-2017 IPR029039 Flavoprotein-like domain TK78_RS14925 b353e9c5bd4c0d1f39c1def0e4a59541 356 SUPERFAMILY SSF55729 209 337 6.73E-22 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS14925 b353e9c5bd4c0d1f39c1def0e4a59541 356 Pfam PF03358 NADPH-dependent FMN reductase 7 152 4.5E-30 T 09-03-2017 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 TK78_RS14925 b353e9c5bd4c0d1f39c1def0e4a59541 356 Pfam PF00583 Acetyltransferase (GNAT) family 262 334 6.2E-14 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS14925 b353e9c5bd4c0d1f39c1def0e4a59541 356 Gene3D G3DSA:3.40.630.30 209 337 3.2E-21 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS14925 b353e9c5bd4c0d1f39c1def0e4a59541 356 SUPERFAMILY SSF52218 7 155 2.79E-32 T 09-03-2017 IPR029039 Flavoprotein-like domain TK78_RS05900 8053e2b0cd6cc81ef26afda1f808c457 327 Pfam PF14257 Domain of unknown function (DUF4349) 31 298 4.5E-75 T 09-03-2017 IPR025645 Domain of unknown function DUF4349 TK78_RS30965 ea8888eb3d2f5910e1516221d5da0476 152 Pfam PF00355 Rieske [2Fe-2S] domain 61 138 1.2E-15 T 09-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 TK78_RS30965 ea8888eb3d2f5910e1516221d5da0476 152 PRINTS PR00162 Rieske 2Fe-2S subunit signature 92 103 1.7E-5 T 09-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 TK78_RS30965 ea8888eb3d2f5910e1516221d5da0476 152 PRINTS PR00162 Rieske 2Fe-2S subunit signature 112 124 1.7E-5 T 09-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 TK78_RS30965 ea8888eb3d2f5910e1516221d5da0476 152 PRINTS PR00162 Rieske 2Fe-2S subunit signature 125 137 1.7E-5 T 09-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 TK78_RS30965 ea8888eb3d2f5910e1516221d5da0476 152 SUPERFAMILY SSF50022 59 151 2.49E-27 T 09-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 TK78_RS30965 ea8888eb3d2f5910e1516221d5da0476 152 Gene3D G3DSA:2.102.10.10 11 150 9.1E-30 T 09-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 TK78_RS29860 8551d2b997639fc8976fa2aac854f880 514 Pfam PF07690 Major Facilitator Superfamily 26 417 2.2E-50 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS29860 8551d2b997639fc8976fa2aac854f880 514 SUPERFAMILY SSF103473 6 206 2.35E-65 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS29860 8551d2b997639fc8976fa2aac854f880 514 SUPERFAMILY SSF103473 478 505 2.35E-65 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS29860 8551d2b997639fc8976fa2aac854f880 514 SUPERFAMILY SSF103473 256 427 2.35E-65 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS29860 8551d2b997639fc8976fa2aac854f880 514 Gene3D G3DSA:1.20.1250.20 279 428 3.7E-16 T 09-03-2017 TK78_RS29860 8551d2b997639fc8976fa2aac854f880 514 Gene3D G3DSA:1.20.1250.20 479 505 3.7E-16 T 09-03-2017 TK78_RS29860 8551d2b997639fc8976fa2aac854f880 514 PRINTS PR01036 Tetracycline resistance protein TetB signature 85 107 7.0E-5 T 09-03-2017 TK78_RS29860 8551d2b997639fc8976fa2aac854f880 514 PRINTS PR01036 Tetracycline resistance protein TetB signature 408 427 7.0E-5 T 09-03-2017 TK78_RS29860 8551d2b997639fc8976fa2aac854f880 514 PRINTS PR01036 Tetracycline resistance protein TetB signature 147 171 7.0E-5 T 09-03-2017 TK78_RS29860 8551d2b997639fc8976fa2aac854f880 514 Gene3D G3DSA:1.20.1250.20 14 204 3.5E-29 T 09-03-2017 TK78_RS33365 3abaca42a3c941d5002eefb3527cf981 453 Gene3D G3DSA:3.40.640.10 27 311 1.6E-119 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS33365 3abaca42a3c941d5002eefb3527cf981 453 ProSitePatterns PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 222 236 - T 09-03-2017 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 Reactome: R-HSA-1614558|Reactome: R-HSA-1614603|Reactome: R-HSA-2408508 TK78_RS33365 3abaca42a3c941d5002eefb3527cf981 453 TIGRFAM TIGR01326 OAH_OAS_sulfhy: O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase 28 446 5.2E-197 T 09-03-2017 IPR006235 O-acetylhomoserine/O-acetylserine sulfhydrylase GO:0006520|GO:0016765 KEGG: 00270+2.5.1.49|MetaCyc: PWY-5344|MetaCyc: PWY-7174 TK78_RS33365 3abaca42a3c941d5002eefb3527cf981 453 SUPERFAMILY SSF53383 26 446 6.39E-122 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS33365 3abaca42a3c941d5002eefb3527cf981 453 Pfam PF01053 Cys/Met metabolism PLP-dependent enzyme 29 446 5.9E-138 T 09-03-2017 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 Reactome: R-HSA-1614558|Reactome: R-HSA-1614603|Reactome: R-HSA-2408508 TK78_RS33365 3abaca42a3c941d5002eefb3527cf981 453 Gene3D G3DSA:3.90.1150.10 313 449 1.9E-47 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS33365 3abaca42a3c941d5002eefb3527cf981 453 PIRSF PIRSF001434 15 450 1.1E-128 T 09-03-2017 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 Reactome: R-HSA-1614558|Reactome: R-HSA-1614603|Reactome: R-HSA-2408508 TK78_RS15740 94893dd5710e11c309494089212072bd 178 SMART SM00347 36 135 1.0E-7 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS15740 94893dd5710e11c309494089212072bd 178 Gene3D G3DSA:1.10.10.10 18 149 6.2E-28 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS15740 94893dd5710e11c309494089212072bd 178 Pfam PF12802 MarR family 42 99 2.1E-16 T 09-03-2017 TK78_RS15740 94893dd5710e11c309494089212072bd 178 SUPERFAMILY SSF46785 18 150 9.47E-25 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS13890 e39aa9c0e3eca27d09d015b9d484c268 347 Pfam PF01032 FecCD transport family 22 330 9.9E-89 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS13890 e39aa9c0e3eca27d09d015b9d484c268 347 SUPERFAMILY SSF81345 9 331 7.32E-75 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS13890 e39aa9c0e3eca27d09d015b9d484c268 347 Gene3D G3DSA:1.10.3470.10 11 336 9.4E-98 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS24780 f2863f6a027ae47754c34e295b126384 248 Gene3D G3DSA:3.40.1280.10 6 248 2.4E-69 T 09-03-2017 IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal TK78_RS24780 f2863f6a027ae47754c34e295b126384 248 SUPERFAMILY SSF75217 73 247 1.78E-45 T 09-03-2017 IPR029028 Alpha/beta knot methyltransferases TK78_RS24780 f2863f6a027ae47754c34e295b126384 248 PIRSF PIRSF015601 2 247 2.5E-47 T 09-03-2017 IPR006700 Ribosomal RNA small subunit methyltransferase E GO:0006364|GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 TK78_RS24780 f2863f6a027ae47754c34e295b126384 248 TIGRFAM TIGR00046 TIGR00046: RNA methyltransferase, RsmE family 16 240 2.5E-34 T 09-03-2017 IPR006700 Ribosomal RNA small subunit methyltransferase E GO:0006364|GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 TK78_RS24780 f2863f6a027ae47754c34e295b126384 248 SUPERFAMILY SSF88697 5 65 7.46E-10 T 09-03-2017 IPR015947 PUA-like domain TK78_RS24780 f2863f6a027ae47754c34e295b126384 248 Pfam PF04452 RNA methyltransferase 19 240 1.0E-61 T 09-03-2017 IPR006700 Ribosomal RNA small subunit methyltransferase E GO:0006364|GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 TK78_RS33260 6c0a1a8ff90ae24fe2feee9cc5c8e0ae 105 SUPERFAMILY SSF51182 21 103 7.97E-7 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS33260 6c0a1a8ff90ae24fe2feee9cc5c8e0ae 105 Gene3D G3DSA:2.60.120.10 19 102 6.3E-8 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS02390 d25cb39bc608e7564870d20daa60253c 172 SUPERFAMILY SSF46785 34 147 1.71E-24 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS02390 d25cb39bc608e7564870d20daa60253c 172 Gene3D G3DSA:1.10.10.10 21 147 3.5E-28 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS02390 d25cb39bc608e7564870d20daa60253c 172 ProSitePatterns PS01117 MarR-type HTH domain signature. 73 107 - T 09-03-2017 IPR023187 Transcriptional regulator MarR-type, conserved site TK78_RS02390 d25cb39bc608e7564870d20daa60253c 172 SMART SM00347 34 134 1.1E-18 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS02390 d25cb39bc608e7564870d20daa60253c 172 Pfam PF01047 MarR family 42 99 2.0E-12 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS10535 7b2bd0718c6edaae466b14aac42cbe26 186 SUPERFAMILY SSF55811 49 181 2.03E-18 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS10535 7b2bd0718c6edaae466b14aac42cbe26 186 Gene3D G3DSA:3.90.79.10 56 180 3.2E-17 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS10535 7b2bd0718c6edaae466b14aac42cbe26 186 Pfam PF00293 NUDIX domain 57 168 1.6E-10 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS20155 56328d35184e5cd3719ca65022e050cb 382 Gene3D G3DSA:3.40.190.10 164 307 3.8E-23 T 09-03-2017 TK78_RS20155 56328d35184e5cd3719ca65022e050cb 382 Pfam PF13343 Bacterial extracellular solute-binding protein 123 338 3.0E-34 T 09-03-2017 TK78_RS20155 56328d35184e5cd3719ca65022e050cb 382 SUPERFAMILY SSF53850 61 363 2.22E-49 T 09-03-2017 TK78_RS20155 56328d35184e5cd3719ca65022e050cb 382 Gene3D G3DSA:3.40.190.10 10 162 2.2E-32 T 09-03-2017 TK78_RS20155 56328d35184e5cd3719ca65022e050cb 382 Gene3D G3DSA:3.40.190.10 308 340 2.2E-32 T 09-03-2017 TK78_RS01720 4bc2960e8bbb6ce637ecdcc4658e74b2 353 Pfam PF01032 FecCD transport family 16 320 4.9E-66 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS01720 4bc2960e8bbb6ce637ecdcc4658e74b2 353 SUPERFAMILY SSF81345 3 321 3.4E-61 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS01720 4bc2960e8bbb6ce637ecdcc4658e74b2 353 Gene3D G3DSA:1.10.3470.10 2 324 1.7E-75 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS05945 ba186b3ec0d31ad522ff3b2157927c63 463 SUPERFAMILY SSF52266 3 210 3.16E-33 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS05945 ba186b3ec0d31ad522ff3b2157927c63 463 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 7 200 3.8E-7 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS05945 ba186b3ec0d31ad522ff3b2157927c63 463 Gene3D G3DSA:3.40.50.1110 3 214 1.3E-43 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS13310 2f28463fb437f757b134f563c56a588b 150 Hamap MF_00799 UPF0336 protein . 1 148 35.966 T 09-03-2017 IPR016709 Uncharacterised protein family UPF0336 TK78_RS13310 2f28463fb437f757b134f563c56a588b 150 SUPERFAMILY SSF54637 7 147 2.26E-38 T 09-03-2017 IPR029069 HotDog domain TK78_RS13310 2f28463fb437f757b134f563c56a588b 150 Gene3D G3DSA:3.10.129.10 1 148 6.5E-38 T 09-03-2017 IPR029069 HotDog domain TK78_RS13310 2f28463fb437f757b134f563c56a588b 150 PIRSF PIRSF018072 1 150 1.1E-58 T 09-03-2017 IPR016709 Uncharacterised protein family UPF0336 TK78_RS13310 2f28463fb437f757b134f563c56a588b 150 Pfam PF13452 N-terminal half of MaoC dehydratase 7 137 4.4E-35 T 09-03-2017 TK78_RS04345 a42e757110a79054c94c4ff3c2530a4a 269 SUPERFAMILY SSF53335 13 251 8.01E-46 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS04345 a42e757110a79054c94c4ff3c2530a4a 269 PIRSF PIRSF017393 1 269 1.4E-98 T 09-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type TK78_RS04345 a42e757110a79054c94c4ff3c2530a4a 269 Pfam PF04672 S-adenosyl methyltransferase 10 269 1.8E-104 T 09-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type TK78_RS04345 a42e757110a79054c94c4ff3c2530a4a 269 Gene3D G3DSA:3.40.50.150 2 269 7.0E-107 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS13540 06baef91abf42d89eb9e19fd675231c9 343 Pfam PF00005 ABC transporter 53 197 2.5E-24 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS13540 06baef91abf42d89eb9e19fd675231c9 343 Gene3D G3DSA:3.40.50.300 30 261 1.3E-62 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13540 06baef91abf42d89eb9e19fd675231c9 343 ProSitePatterns PS00211 ABC transporters family signature. 169 183 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS13540 06baef91abf42d89eb9e19fd675231c9 343 SUPERFAMILY SSF52540 31 259 4.32E-56 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS13540 06baef91abf42d89eb9e19fd675231c9 343 SMART SM00382 61 254 1.3E-11 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS13680 7dfc14a042771398cd5b6ca4df6320a2 245 SUPERFAMILY SSF56300 1 241 6.69E-45 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS13680 7dfc14a042771398cd5b6ca4df6320a2 245 Hamap MF_00905 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA [cpdA]. 1 244 36.017 T 09-03-2017 IPR026575 3,5-cyclic adenosine monophosphate phosphodiesterase CpdA GO:0004115 KEGG: 00230+3.1.4.53 TK78_RS13680 7dfc14a042771398cd5b6ca4df6320a2 245 Gene3D G3DSA:3.60.21.10 3 235 3.4E-32 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS13680 7dfc14a042771398cd5b6ca4df6320a2 245 Pfam PF00149 Calcineurin-like phosphoesterase 3 187 1.3E-12 T 09-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 TK78_RS28450 7e93e18e4ce5a454bd6e01a9d8a7d37a 172 SMART SM00855 8 119 6.6E-5 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS28450 7e93e18e4ce5a454bd6e01a9d8a7d37a 172 Gene3D G3DSA:3.40.50.1240 3 171 7.8E-56 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS28450 7e93e18e4ce5a454bd6e01a9d8a7d37a 172 SUPERFAMILY SSF53254 6 155 8.99E-26 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS28450 7e93e18e4ce5a454bd6e01a9d8a7d37a 172 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 9 102 3.8E-12 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS12975 c6e3c98960933ab4a214817b81b46ad4 331 PIRSF PIRSF000545 9 331 1.2E-139 T 09-03-2017 IPR004566 Bacterial pantothenate kinase GO:0004594|GO:0005524|GO:0005737|GO:0015937 KEGG: 00770+2.7.1.33|MetaCyc: PWY-3961 TK78_RS12975 c6e3c98960933ab4a214817b81b46ad4 331 SUPERFAMILY SSF52540 19 329 1.23E-68 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS12975 c6e3c98960933ab4a214817b81b46ad4 331 Pfam PF00485 Phosphoribulokinase / Uridine kinase family 104 257 8.8E-10 T 09-03-2017 IPR006083 Phosphoribulokinase/uridine kinase GO:0005524|GO:0008152|GO:0016301 TK78_RS12975 c6e3c98960933ab4a214817b81b46ad4 331 TIGRFAM TIGR00554 panK_bact: pantothenate kinase 18 330 2.1E-123 T 09-03-2017 IPR004566 Bacterial pantothenate kinase GO:0004594|GO:0005524|GO:0005737|GO:0015937 KEGG: 00770+2.7.1.33|MetaCyc: PWY-3961 TK78_RS12975 c6e3c98960933ab4a214817b81b46ad4 331 Hamap MF_00215 Pantothenate kinase [coaA]. 1 331 170.03 T 09-03-2017 IPR004566 Bacterial pantothenate kinase GO:0004594|GO:0005524|GO:0005737|GO:0015937 KEGG: 00770+2.7.1.33|MetaCyc: PWY-3961 TK78_RS12975 c6e3c98960933ab4a214817b81b46ad4 331 Gene3D G3DSA:3.40.50.300 18 329 1.2E-102 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09890 288b2a6ecff2a9fbf2b8d3c034073c21 460 Pfam PF01098 Cell cycle protein 81 437 7.7E-73 T 09-03-2017 IPR001182 Cell cycle protein FtsW/RodA GO:0016021|GO:0051301 TK78_RS24885 e77c2c7f3a6fb78c72f55f3f3e39a5b3 271 Gene3D G3DSA:3.40.1180.10 33 267 1.2E-94 T 09-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TK78_RS24885 e77c2c7f3a6fb78c72f55f3f3e39a5b3 271 Pfam PF01255 Putative undecaprenyl diphosphate synthase 42 262 7.9E-77 T 09-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TK78_RS24885 e77c2c7f3a6fb78c72f55f3f3e39a5b3 271 SUPERFAMILY SSF64005 35 258 1.7E-86 T 09-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TK78_RS24885 e77c2c7f3a6fb78c72f55f3f3e39a5b3 271 TIGRFAM TIGR00055 uppS: di-trans,poly-cis-decaprenylcistransferase 35 262 3.8E-81 T 09-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TK78_RS24885 e77c2c7f3a6fb78c72f55f3f3e39a5b3 271 Hamap MF_01139 Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) [uppS]. 35 263 39.285 T 09-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TK78_RS24885 e77c2c7f3a6fb78c72f55f3f3e39a5b3 271 ProSitePatterns PS01066 Undecaprenyl pyrophosphate synthase family signature. 208 225 - T 09-03-2017 IPR018520 Di-trans-poly-cis-decaprenylcistransferase-like, conserved site GO:0016765 Reactome: R-HSA-446199|Reactome: R-HSA-4755609 TK78_RS08220 7663ca49d9734ee132dd1ccc9af2f248 328 Pfam PF00296 Luciferase-like monooxygenase 13 252 8.6E-37 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS08220 7663ca49d9734ee132dd1ccc9af2f248 328 Gene3D G3DSA:3.20.20.30 16 314 1.3E-60 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS08220 7663ca49d9734ee132dd1ccc9af2f248 328 SUPERFAMILY SSF51679 3 314 1.03E-53 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS16080 1247095692de088d14129c93e59069e5 150 SMART SM00422 18 87 6.8E-25 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS16080 1247095692de088d14129c93e59069e5 150 SUPERFAMILY SSF46955 18 105 9.61E-19 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS16080 1247095692de088d14129c93e59069e5 150 Pfam PF13411 MerR HTH family regulatory protein 18 85 2.4E-16 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS16080 1247095692de088d14129c93e59069e5 150 ProSitePatterns PS00552 MerR-type HTH domain signature. 21 43 - T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS16080 1247095692de088d14129c93e59069e5 150 Gene3D G3DSA:1.10.1660.10 19 115 2.9E-21 T 09-03-2017 TK78_RS19275 d225a2df4b61bc06dca8ca69c6a2ab7b 255 Gene3D G3DSA:3.60.10.10 6 109 1.4E-6 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS19275 d225a2df4b61bc06dca8ca69c6a2ab7b 255 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 9 163 7.2E-11 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS19275 d225a2df4b61bc06dca8ca69c6a2ab7b 255 SUPERFAMILY SSF56219 6 246 6.0E-16 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS21670 011356365dcd83ff481a4ffa8396344a 423 Pfam PF02687 FtsX-like permease family 304 417 4.3E-21 T 09-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 TK78_RS21670 011356365dcd83ff481a4ffa8396344a 423 Pfam PF12704 MacB-like periplasmic core domain 45 260 5.9E-14 T 09-03-2017 IPR025857 MacB-like periplasmic core domain TK78_RS31515 f528da6c5c4124098bf94c64e886430b 339 Gene3D G3DSA:3.10.580.10 222 332 2.2E-20 T 09-03-2017 TK78_RS31515 f528da6c5c4124098bf94c64e886430b 339 SMART SM00116 225 273 0.26 T 09-03-2017 IPR000644 CBS domain TK78_RS31515 f528da6c5c4124098bf94c64e886430b 339 SMART SM00116 285 333 2.0E-4 T 09-03-2017 IPR000644 CBS domain TK78_RS31515 f528da6c5c4124098bf94c64e886430b 339 SUPERFAMILY SSF54631 205 334 9.2E-27 T 09-03-2017 TK78_RS31515 f528da6c5c4124098bf94c64e886430b 339 Pfam PF00571 CBS domain 284 333 1.4E-8 T 09-03-2017 IPR000644 CBS domain TK78_RS31515 f528da6c5c4124098bf94c64e886430b 339 Pfam PF00571 CBS domain 217 272 4.5E-4 T 09-03-2017 IPR000644 CBS domain TK78_RS31515 f528da6c5c4124098bf94c64e886430b 339 Pfam PF01595 Domain of unknown function DUF21 8 198 2.7E-39 T 09-03-2017 IPR002550 Domain of unknown function DUF21 TK78_RS15415 e99f575b7e94de0ee77ef28ba086ae3d 253 Pfam PF00293 NUDIX domain 74 195 4.8E-11 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS15415 e99f575b7e94de0ee77ef28ba086ae3d 253 SUPERFAMILY SSF55811 65 230 1.97E-25 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS15415 e99f575b7e94de0ee77ef28ba086ae3d 253 Gene3D G3DSA:3.90.79.10 71 235 1.0E-34 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS17810 6b50361108b1ae870f5bfde4bf85ffff 318 Gene3D G3DSA:2.60.120.10 24 282 8.3E-78 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS17810 6b50361108b1ae870f5bfde4bf85ffff 318 SUPERFAMILY SSF51182 24 316 2.42E-82 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS17810 6b50361108b1ae870f5bfde4bf85ffff 318 PIRSF PIRSF006232 22 318 1.9E-92 T 09-03-2017 IPR012093 Pirin TK78_RS17810 6b50361108b1ae870f5bfde4bf85ffff 318 Pfam PF02678 Pirin 41 146 5.0E-31 T 09-03-2017 IPR003829 Pirin, N-terminal domain TK78_RS17810 6b50361108b1ae870f5bfde4bf85ffff 318 Pfam PF05726 Pirin C-terminal cupin domain 202 309 2.0E-32 T 09-03-2017 IPR008778 Pirin, C-terminal domain TK78_RS23895 6da32df73e382f42942d0b3bf7da3129 105 Pfam PF00403 Heavy-metal-associated domain 39 99 1.1E-13 T 09-03-2017 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 TK78_RS23895 6da32df73e382f42942d0b3bf7da3129 105 ProSitePatterns PS01047 Heavy-metal-associated domain. 42 70 - T 09-03-2017 IPR017969 Heavy-metal-associated, conserved site GO:0030001|GO:0046872 TK78_RS23895 6da32df73e382f42942d0b3bf7da3129 105 Gene3D G3DSA:3.30.70.100 37 100 5.2E-18 T 09-03-2017 TK78_RS23895 6da32df73e382f42942d0b3bf7da3129 105 SUPERFAMILY SSF55008 32 100 1.31E-14 T 09-03-2017 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 TK78_RS11040 9087f61badfa2827cdbc7f25307cce90 409 Pfam PF00232 Glycosyl hydrolase family 1 17 246 6.4E-44 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS11040 9087f61badfa2827cdbc7f25307cce90 409 Pfam PF00232 Glycosyl hydrolase family 1 286 401 6.8E-23 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS11040 9087f61badfa2827cdbc7f25307cce90 409 Gene3D G3DSA:3.20.20.80 17 405 2.4E-101 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS11040 9087f61badfa2827cdbc7f25307cce90 409 SUPERFAMILY SSF51445 17 404 1.8E-106 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS11040 9087f61badfa2827cdbc7f25307cce90 409 PRINTS PR00131 Glycosyl hydrolase family 1 signature 329 340 4.8E-14 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS11040 9087f61badfa2827cdbc7f25307cce90 409 PRINTS PR00131 Glycosyl hydrolase family 1 signature 373 385 4.8E-14 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS11040 9087f61badfa2827cdbc7f25307cce90 409 PRINTS PR00131 Glycosyl hydrolase family 1 signature 261 275 4.8E-14 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS11040 9087f61badfa2827cdbc7f25307cce90 409 PRINTS PR00131 Glycosyl hydrolase family 1 signature 350 367 4.8E-14 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS11040 9087f61badfa2827cdbc7f25307cce90 409 PRINTS PR00131 Glycosyl hydrolase family 1 signature 317 325 4.8E-14 T 09-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 TK78_RS28910 e0ce0e4a127a2f76d2b694ac2a731266 327 SUPERFAMILY SSF53850 118 299 1.36E-8 T 09-03-2017 TK78_RS28910 e0ce0e4a127a2f76d2b694ac2a731266 327 Pfam PF03401 Tripartite tricarboxylate transporter family receptor 54 327 4.8E-30 T 09-03-2017 IPR005064 Bordetella uptake gene GO:0030288 TK78_RS28910 e0ce0e4a127a2f76d2b694ac2a731266 327 PIRSF PIRSF017082 2 327 1.3E-95 T 09-03-2017 IPR005064 Bordetella uptake gene GO:0030288 TK78_RS27890 7c0184f1648043fc1c357229349ae739 111 Hamap MF_01483 RNA polymerase-binding protein RbpA [rbpA]. 17 110 23.865 T 09-03-2017 IPR025182 RNA polymerase-binding protein RbpA GO:0001000|GO:0045893 TK78_RS27890 7c0184f1648043fc1c357229349ae739 111 Pfam PF13397 RNA polymerase-binding protein 5 108 2.8E-43 T 09-03-2017 IPR025182 RNA polymerase-binding protein RbpA GO:0001000|GO:0045893 TK78_RS27890 7c0184f1648043fc1c357229349ae739 111 ProSitePatterns PS00202 Rubredoxin signature. 51 61 - T 09-03-2017 IPR018527 Rubredoxin, iron-binding site GO:0046872 TK78_RS16280 8ebe2cdfb9cf34baefa7e6fceb71f0d7 320 SUPERFAMILY SSF56601 76 302 1.65E-38 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS16280 8ebe2cdfb9cf34baefa7e6fceb71f0d7 320 SUPERFAMILY SSF56601 13 26 1.65E-38 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS16280 8ebe2cdfb9cf34baefa7e6fceb71f0d7 320 Gene3D G3DSA:3.40.710.10 78 294 5.4E-55 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS16280 8ebe2cdfb9cf34baefa7e6fceb71f0d7 320 Pfam PF00768 D-alanyl-D-alanine carboxypeptidase 78 273 5.8E-31 T 09-03-2017 IPR001967 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, N-terminal GO:0006508|GO:0009002 TK78_RS16280 8ebe2cdfb9cf34baefa7e6fceb71f0d7 320 PRINTS PR00725 D-Ala-D-Ala carboxypeptidase 1 (S11) family signature 170 183 1.3E-13 T 09-03-2017 IPR018044 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A GO:0006508|GO:0009002 TK78_RS16280 8ebe2cdfb9cf34baefa7e6fceb71f0d7 320 PRINTS PR00725 D-Ala-D-Ala carboxypeptidase 1 (S11) family signature 143 160 1.3E-13 T 09-03-2017 IPR018044 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A GO:0006508|GO:0009002 TK78_RS16280 8ebe2cdfb9cf34baefa7e6fceb71f0d7 320 PRINTS PR00725 D-Ala-D-Ala carboxypeptidase 1 (S11) family signature 86 97 1.3E-13 T 09-03-2017 IPR018044 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A GO:0006508|GO:0009002 TK78_RS23970 db423febf88c90328057c585a347ca1c 328 SUPERFAMILY SSF48317 63 221 3.92E-30 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS23970 db423febf88c90328057c585a347ca1c 328 Gene3D G3DSA:1.20.144.10 81 218 9.4E-30 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS23970 db423febf88c90328057c585a347ca1c 328 SMART SM00014 105 215 2.3E-15 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS23970 db423febf88c90328057c585a347ca1c 328 Pfam PF01569 PAP2 superfamily 107 216 1.4E-17 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS03385 e6ec5edb9d0f6983d6aa75ce83329cae 324 PIRSF PIRSF000346 1 322 9.8E-115 T 09-03-2017 IPR005067 Fatty acid desaturase, type 2 GO:0006631|GO:0045300|GO:0055114 TK78_RS03385 e6ec5edb9d0f6983d6aa75ce83329cae 324 SUPERFAMILY SSF47240 6 318 2.28E-80 T 09-03-2017 IPR009078 Ferritin-like superfamily TK78_RS03385 e6ec5edb9d0f6983d6aa75ce83329cae 324 Pfam PF03405 Fatty acid desaturase 17 315 5.6E-75 T 09-03-2017 IPR005067 Fatty acid desaturase, type 2 GO:0006631|GO:0045300|GO:0055114 TK78_RS03385 e6ec5edb9d0f6983d6aa75ce83329cae 324 Gene3D G3DSA:1.10.620.20 8 312 1.1E-106 T 09-03-2017 IPR012348 Ribonucleotide reductase-related GO:0016491|GO:0055114 Reactome: R-HSA-499943 TK78_RS30040 0f174885de050414a2b4b8f7e6ac4ecb 198 Pfam PF14280 Domain of unknown function (DUF4365) 44 191 1.3E-22 T 09-03-2017 IPR025375 Domain of unknown function DUF4365 TK78_RS26010 25b3ba7f861a7098c8b78a0650db9159 266 Pfam PF03883 Protein of unknown function (DUF328) 2 247 1.4E-38 T 09-03-2017 IPR005583 Peroxide stress protein YaaA TK78_RS17560 0730f9c4b20bec6cec06e42bdbba2684 432 Pfam PF10009 Uncharacterized protein conserved in bacteria (DUF2252) 29 418 3.0E-131 T 09-03-2017 IPR018721 Protein of unknown function DUF2252 TK78_RS00510 a78916f4055270ea43d84bae7a1eda13 183 SUPERFAMILY SSF55729 10 175 6.49E-30 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS00510 a78916f4055270ea43d84bae7a1eda13 183 Gene3D G3DSA:3.40.630.30 7 177 2.3E-37 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS00510 a78916f4055270ea43d84bae7a1eda13 183 Pfam PF13302 Acetyltransferase (GNAT) domain 18 158 1.2E-21 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS04300 4f17093046e49007a7b932c604366063 372 PIRSF PIRSF006078 4 372 6.2E-121 T 09-03-2017 IPR004381 Glycerate kinase GO:0008887|GO:0031388 TK78_RS04300 4f17093046e49007a7b932c604366063 372 TIGRFAM TIGR00045 TIGR00045: glycerate kinase 5 368 2.3E-118 T 09-03-2017 IPR004381 Glycerate kinase GO:0008887|GO:0031388 TK78_RS04300 4f17093046e49007a7b932c604366063 372 SUPERFAMILY SSF110738 5 369 5.36E-117 T 09-03-2017 IPR004381 Glycerate kinase GO:0008887|GO:0031388 TK78_RS04300 4f17093046e49007a7b932c604366063 372 Gene3D G3DSA:3.90.1510.10 45 271 5.1E-86 T 09-03-2017 IPR018193 Glycerate kinase, flavodoxin-like domain GO:0008887|GO:0031388 TK78_RS04300 4f17093046e49007a7b932c604366063 372 Pfam PF02595 Glycerate kinase family 6 368 4.4E-130 T 09-03-2017 IPR004381 Glycerate kinase GO:0008887|GO:0031388 TK78_RS23065 47ddc57c45ea94ed41c06ad47a6d3dd4 252 Gene3D G3DSA:3.30.450.40 87 242 1.5E-25 T 09-03-2017 IPR029016 GAF domain-like TK78_RS23065 47ddc57c45ea94ed41c06ad47a6d3dd4 252 Pfam PF09339 IclR helix-turn-helix domain 14 63 4.1E-8 T 09-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 TK78_RS23065 47ddc57c45ea94ed41c06ad47a6d3dd4 252 SMART SM00346 11 100 1.4E-6 T 09-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 TK78_RS23065 47ddc57c45ea94ed41c06ad47a6d3dd4 252 SUPERFAMILY SSF55781 77 242 2.22E-24 T 09-03-2017 IPR029016 GAF domain-like TK78_RS23065 47ddc57c45ea94ed41c06ad47a6d3dd4 252 SUPERFAMILY SSF46785 12 83 4.4E-12 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS23065 47ddc57c45ea94ed41c06ad47a6d3dd4 252 Pfam PF01614 Bacterial transcriptional regulator 133 227 7.9E-15 T 09-03-2017 IPR014757 Transcription regulator IclR, C-terminal TK78_RS23065 47ddc57c45ea94ed41c06ad47a6d3dd4 252 Gene3D G3DSA:1.10.10.10 10 79 3.0E-14 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS22900 9ca141043351ddde1b66083d372baba2 334 Gene3D G3DSA:1.25.40.10 12 57 9.7E-4 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS22900 9ca141043351ddde1b66083d372baba2 334 Gene3D G3DSA:1.25.40.10 96 129 9.7E-4 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS22900 9ca141043351ddde1b66083d372baba2 334 Pfam PF02810 SEC-C motif 316 333 1.7E-4 T 09-03-2017 IPR004027 SEC-C motif TK78_RS14365 e2648afc265b3caac5291e6752b95e58 343 Gene3D G3DSA:2.120.10.30 45 209 7.7E-7 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS14365 e2648afc265b3caac5291e6752b95e58 343 Gene3D G3DSA:2.120.10.60 210 282 5.8E-4 T 09-03-2017 TK78_RS14365 e2648afc265b3caac5291e6752b95e58 343 SUPERFAMILY SSF75011 46 282 3.4E-15 T 09-03-2017 TK78_RS18280 19a5a74fba10a49e092700387fc4cb2c 85 Pfam PF11273 Protein of unknown function (DUF3073) 2 62 2.5E-20 T 09-03-2017 IPR021426 Protein of unknown function DUF3073 TK78_RS30015 24267e91864fa8f6dfaeb00b07507dbc 151 TIGRFAM TIGR02611 TIGR02611: TIGR02611 family protein 29 146 5.2E-38 T 09-03-2017 IPR013434 Conserved hypothetical protein CHP02611 TK78_RS30015 24267e91864fa8f6dfaeb00b07507dbc 151 Pfam PF09656 Putative transmembrane protein (PGPGW) 50 102 4.6E-21 T 09-03-2017 IPR019099 Uncharacterised protein family PGPGW, transmembrane TK78_RS01445 4281bdc57fbc1752fb7bcd8963398964 529 SUPERFAMILY SSF63825 104 360 5.75E-6 T 09-03-2017 TK78_RS27540 5a4a98282f724221e3a9d8ba7098feb2 851 SUPERFAMILY SSF55486 196 449 3.81E-69 T 09-03-2017 TK78_RS27540 5a4a98282f724221e3a9d8ba7098feb2 851 SUPERFAMILY SSF63737 2 189 2.35E-34 T 09-03-2017 TK78_RS27540 5a4a98282f724221e3a9d8ba7098feb2 851 TIGRFAM TIGR02412 pepN_strep_liv: aminopeptidase N 4 845 0.0 T 09-03-2017 IPR012778 Peptidase M1, aminopeptidase GO:0004177|GO:0006508 KEGG: 00480+3.4.11.2|MetaCyc: PWY-4061|MetaCyc: PWY-6842|MetaCyc: PWY-7112 TK78_RS27540 5a4a98282f724221e3a9d8ba7098feb2 851 Pfam PF11838 ERAP1-like C-terminal domain 529 839 4.4E-48 T 09-03-2017 IPR024571 ERAP1-like C-terminal domain TK78_RS27540 5a4a98282f724221e3a9d8ba7098feb2 851 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 253 263 2.3E-21 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS27540 5a4a98282f724221e3a9d8ba7098feb2 851 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 287 302 2.3E-21 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS27540 5a4a98282f724221e3a9d8ba7098feb2 851 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 306 318 2.3E-21 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS27540 5a4a98282f724221e3a9d8ba7098feb2 851 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 172 187 2.3E-21 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS27540 5a4a98282f724221e3a9d8ba7098feb2 851 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 129 144 2.3E-21 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS27540 5a4a98282f724221e3a9d8ba7098feb2 851 Gene3D G3DSA:1.10.390.10 300 450 6.2E-37 T 09-03-2017 TK78_RS27540 5a4a98282f724221e3a9d8ba7098feb2 851 Pfam PF01433 Peptidase family M1 21 382 3.2E-60 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS27700 f2109849d29e7ed182da6ca774a0a244 27 SUPERFAMILY SSF50978 2 27 9.16E-5 T 09-03-2017 IPR017986 WD40-repeat-containing domain GO:0005515 TK78_RS27700 f2109849d29e7ed182da6ca774a0a244 27 Gene3D G3DSA:2.130.10.10 2 27 3.8E-6 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS01560 93b0cc522b2a5630ebc6547e0700d6bf 190 SUPERFAMILY SSF52821 4 103 3.67E-25 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS01560 93b0cc522b2a5630ebc6547e0700d6bf 190 Pfam PF11127 Protein of unknown function (DUF2892) 115 173 2.3E-9 T 09-03-2017 IPR021309 Protein of unknown function DUF2892 TK78_RS01560 93b0cc522b2a5630ebc6547e0700d6bf 190 ProSitePatterns PS00380 Rhodanese signature 1. 30 41 - T 09-03-2017 IPR001307 Thiosulphate sulfurtransferase, conserved site GO:0004792 KEGG: 00920+2.8.1.1|MetaCyc: PWY-5350 TK78_RS01560 93b0cc522b2a5630ebc6547e0700d6bf 190 SMART SM00450 5 102 1.3E-17 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS01560 93b0cc522b2a5630ebc6547e0700d6bf 190 Pfam PF00581 Rhodanese-like domain 9 97 4.1E-10 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS01560 93b0cc522b2a5630ebc6547e0700d6bf 190 Gene3D G3DSA:3.40.250.10 7 104 1.5E-23 T 09-03-2017 IPR001763 Rhodanese-like domain TK78_RS30430 71a86a776de915e4ec160f157e5a48d7 469 Pfam PF00860 Permease family 34 405 7.4E-71 T 09-03-2017 IPR006043 Xanthine/uracil/vitamin C permease GO:0005215|GO:0006810|GO:0016020|GO:0055085 TK78_RS22780 b2cf7fcd48a1cb53056d572f11cbf57b 301 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 91 291 5.8E-12 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS22780 b2cf7fcd48a1cb53056d572f11cbf57b 301 SUPERFAMILY SSF56219 85 298 5.89E-19 T 09-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase TK78_RS11900 dfce0af7c8a73ce07faf0247cf5968a7 246 SUPERFAMILY SSF46689 21 85 3.45E-14 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS11900 dfce0af7c8a73ce07faf0247cf5968a7 246 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 92 226 2.8E-8 T 09-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 TK78_RS11900 dfce0af7c8a73ce07faf0247cf5968a7 246 Gene3D G3DSA:1.10.357.10 81 225 2.9E-21 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS11900 dfce0af7c8a73ce07faf0247cf5968a7 246 Pfam PF00440 Bacterial regulatory proteins, tetR family 31 75 5.1E-10 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS11900 dfce0af7c8a73ce07faf0247cf5968a7 246 SUPERFAMILY SSF48498 93 226 6.78E-13 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS11900 dfce0af7c8a73ce07faf0247cf5968a7 246 Gene3D G3DSA:1.10.10.60 14 80 4.7E-25 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS02820 9336b537508309e239cc648669f0193e 159 Gene3D G3DSA:1.10.3450.10 18 150 1.5E-25 T 09-03-2017 IPR023203 TTHA0068-like domain TK78_RS02820 9336b537508309e239cc648669f0193e 159 SUPERFAMILY SSF140663 30 148 2.22E-29 T 09-03-2017 IPR023203 TTHA0068-like domain TK78_RS02820 9336b537508309e239cc648669f0193e 159 Pfam PF03745 Domain of unknown function (DUF309) 49 107 2.9E-19 T 09-03-2017 IPR005500 Protein of unknown function DUF309 TK78_RS27105 185d0c6884ace2b7229aa556350c812f 264 Hamap MF_00911 Cell division protein FtsQ [ftsQ]. 31 262 18.255 T 09-03-2017 IPR026579 Cell division protein FtsQ GO:0090529 TK78_RS27105 185d0c6884ace2b7229aa556350c812f 264 Pfam PF08478 POTRA domain, FtsQ-type 62 130 3.6E-16 T 09-03-2017 IPR013685 Polypeptide-transport-associated, FtsQ-type TK78_RS12850 b625f5c7ca532ec35c55b935ee7b73da 181 Gene3D G3DSA:3.40.50.300 25 179 8.7E-45 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS12850 b625f5c7ca532ec35c55b935ee7b73da 181 Pfam PF02367 Threonylcarbamoyl adenosine biosynthesis protein TsaE 31 154 6.3E-30 T 09-03-2017 IPR003442 tRNA threonylcarbamoyl adenosine modification protein TsaE GO:0002949 TK78_RS12850 b625f5c7ca532ec35c55b935ee7b73da 181 SUPERFAMILY SSF52540 47 135 3.28E-11 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS12850 b625f5c7ca532ec35c55b935ee7b73da 181 TIGRFAM TIGR00150 T6A_YjeE: tRNA threonylcarbamoyl adenosine modification protein YjeE 34 154 4.7E-25 T 09-03-2017 IPR003442 tRNA threonylcarbamoyl adenosine modification protein TsaE GO:0002949 TK78_RS19100 c3eb7eaa2a857227b6a02f5e215ca52a 576 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 411 559 7.8E-17 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS19100 c3eb7eaa2a857227b6a02f5e215ca52a 576 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 116 299 2.7E-12 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS19100 c3eb7eaa2a857227b6a02f5e215ca52a 576 Gene3D G3DSA:1.10.3720.10 374 565 1.2E-7 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS19100 c3eb7eaa2a857227b6a02f5e215ca52a 576 Gene3D G3DSA:1.10.3720.10 87 294 3.3E-5 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS19100 c3eb7eaa2a857227b6a02f5e215ca52a 576 SUPERFAMILY SSF161098 378 553 2.18E-8 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS19100 c3eb7eaa2a857227b6a02f5e215ca52a 576 SUPERFAMILY SSF161098 90 288 1.0E-5 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS24245 1e7753435ce0183e9d41ea4bc6aeacdd 150 Pfam PF13673 Acetyltransferase (GNAT) domain 48 130 1.0E-13 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS24245 1e7753435ce0183e9d41ea4bc6aeacdd 150 Gene3D G3DSA:3.40.630.30 3 144 4.1E-27 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS24245 1e7753435ce0183e9d41ea4bc6aeacdd 150 SUPERFAMILY SSF55729 1 139 8.58E-23 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS13570 567b847ea6daf161f846bb655db0ae66 236 Gene3D G3DSA:1.10.3630.10 6 211 4.1E-28 T 09-03-2017 TK78_RS13570 567b847ea6daf161f846bb655db0ae66 236 Pfam PF05719 Golgi phosphoprotein 3 (GPP34) 10 208 1.7E-37 T 09-03-2017 IPR008628 Golgi phosphoprotein 3 GO:0048193|GO:0070273 TK78_RS11730 ee78d388d338c1bf2f2109814b51da07 270 Pfam PF00797 N-acetyltransferase 21 263 3.0E-66 T 09-03-2017 IPR001447 Arylamine N-acetyltransferase GO:0008152|GO:0016407 KEGG: 00232+2.3.1.5|KEGG: 00633+2.3.1.5|KEGG: 00983+2.3.1.5|Reactome: R-HSA-156582 TK78_RS11730 ee78d388d338c1bf2f2109814b51da07 270 Gene3D G3DSA:3.30.2140.10 191 267 4.4E-52 T 09-03-2017 TK78_RS11730 ee78d388d338c1bf2f2109814b51da07 270 Gene3D G3DSA:3.30.2140.10 2 85 4.4E-52 T 09-03-2017 TK78_RS11730 ee78d388d338c1bf2f2109814b51da07 270 SUPERFAMILY SSF54001 1 264 1.06E-74 T 09-03-2017 TK78_RS11730 ee78d388d338c1bf2f2109814b51da07 270 PRINTS PR01543 Arylamine N-acetyltransferase signature 69 91 1.1E-8 T 09-03-2017 IPR001447 Arylamine N-acetyltransferase GO:0008152|GO:0016407 KEGG: 00232+2.3.1.5|KEGG: 00633+2.3.1.5|KEGG: 00983+2.3.1.5|Reactome: R-HSA-156582 TK78_RS11730 ee78d388d338c1bf2f2109814b51da07 270 PRINTS PR01543 Arylamine N-acetyltransferase signature 102 127 1.1E-8 T 09-03-2017 IPR001447 Arylamine N-acetyltransferase GO:0008152|GO:0016407 KEGG: 00232+2.3.1.5|KEGG: 00633+2.3.1.5|KEGG: 00983+2.3.1.5|Reactome: R-HSA-156582 TK78_RS11730 ee78d388d338c1bf2f2109814b51da07 270 PRINTS PR01543 Arylamine N-acetyltransferase signature 21 44 1.1E-8 T 09-03-2017 IPR001447 Arylamine N-acetyltransferase GO:0008152|GO:0016407 KEGG: 00232+2.3.1.5|KEGG: 00633+2.3.1.5|KEGG: 00983+2.3.1.5|Reactome: R-HSA-156582 TK78_RS11730 ee78d388d338c1bf2f2109814b51da07 270 PRINTS PR01543 Arylamine N-acetyltransferase signature 45 68 1.1E-8 T 09-03-2017 IPR001447 Arylamine N-acetyltransferase GO:0008152|GO:0016407 KEGG: 00232+2.3.1.5|KEGG: 00633+2.3.1.5|KEGG: 00983+2.3.1.5|Reactome: R-HSA-156582 TK78_RS04650 ebd9e46f45daeca26a21f270f140e627 507 SUPERFAMILY SSF75304 49 496 1.05E-115 T 09-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 TK78_RS04650 ebd9e46f45daeca26a21f270f140e627 507 Pfam PF01425 Amidase 66 487 1.8E-106 T 09-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 TK78_RS04650 ebd9e46f45daeca26a21f270f140e627 507 Gene3D G3DSA:3.90.1300.10 50 506 8.5E-120 T 09-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 TK78_RS04650 ebd9e46f45daeca26a21f270f140e627 507 ProSitePatterns PS00571 Amidases signature. 191 222 - T 09-03-2017 IPR020556 Amidase, conserved site KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921|Reactome: R-HSA-2142753 TK78_RS19545 61f25950d363907470f044bb322f71d6 416 Gene3D G3DSA:1.20.1250.20 218 393 1.9E-18 T 09-03-2017 TK78_RS19545 61f25950d363907470f044bb322f71d6 416 Gene3D G3DSA:1.20.1250.20 9 184 3.4E-26 T 09-03-2017 TK78_RS19545 61f25950d363907470f044bb322f71d6 416 Pfam PF07690 Major Facilitator Superfamily 7 232 8.1E-24 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS19545 61f25950d363907470f044bb322f71d6 416 SUPERFAMILY SSF103473 4 397 4.05E-55 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS31085 455193718227d44de66b67c74a51e727 90 ProSitePatterns PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 29 58 - T 09-03-2017 IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site Reactome: R-HSA-389661 TK78_RS31085 455193718227d44de66b67c74a51e727 90 Gene3D G3DSA:2.40.50.100 3 82 1.8E-19 T 09-03-2017 TK78_RS31085 455193718227d44de66b67c74a51e727 90 Pfam PF00364 Biotin-requiring enzyme 8 78 1.0E-16 T 09-03-2017 IPR000089 Biotin/lipoyl attachment TK78_RS31085 455193718227d44de66b67c74a51e727 90 SUPERFAMILY SSF51230 5 83 9.03E-21 T 09-03-2017 IPR011053 Single hybrid motif TK78_RS04370 725363c26d10bcb24f04da858e77c069 462 Pfam PF00083 Sugar (and other) transporter 20 438 2.3E-36 T 09-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 TK78_RS04370 725363c26d10bcb24f04da858e77c069 462 ProSitePatterns PS00217 Sugar transport proteins signature 2. 128 153 - T 09-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 TK78_RS04370 725363c26d10bcb24f04da858e77c069 462 Gene3D G3DSA:1.20.1250.20 16 223 6.7E-21 T 09-03-2017 TK78_RS04370 725363c26d10bcb24f04da858e77c069 462 Gene3D G3DSA:1.20.1250.20 242 438 5.1E-27 T 09-03-2017 TK78_RS04370 725363c26d10bcb24f04da858e77c069 462 SUPERFAMILY SSF103473 5 437 7.59E-69 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS04370 725363c26d10bcb24f04da858e77c069 462 TIGRFAM TIGR00883 2A0106: MFS transporter, metabolite:H+ symporter (MHS) family protein 24 422 6.3E-134 T 09-03-2017 IPR004736 Citrate-proton symport GO:0005215|GO:0006810|GO:0016021 TK78_RS28980 de517896d32f921bc42f40920068b9ad 191 SUPERFAMILY SSF46689 2 76 6.16E-16 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS28980 de517896d32f921bc42f40920068b9ad 191 Gene3D G3DSA:1.10.357.10 10 186 2.9E-28 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS28980 de517896d32f921bc42f40920068b9ad 191 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 33 56 3.7E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS28980 de517896d32f921bc42f40920068b9ad 191 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 12 25 3.7E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS28980 de517896d32f921bc42f40920068b9ad 191 Pfam PF00440 Bacterial regulatory proteins, tetR family 12 58 1.1E-12 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS23825 6ac220901a36a6056350d1b6aa97ecf3 235 Gene3D G3DSA:1.25.40.10 157 218 6.6E-4 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS23825 6ac220901a36a6056350d1b6aa97ecf3 235 SUPERFAMILY SSF54593 16 129 1.78E-16 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS23825 6ac220901a36a6056350d1b6aa97ecf3 235 Gene3D G3DSA:3.10.180.10 1 132 6.3E-28 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS05210 75ca7734ef145ea570b0e81769de0ff8 77 Gene3D G3DSA:1.10.1200.10 3 76 7.0E-14 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS05210 75ca7734ef145ea570b0e81769de0ff8 77 SUPERFAMILY SSF47336 5 75 1.96E-13 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS05210 75ca7734ef145ea570b0e81769de0ff8 77 Pfam PF00550 Phosphopantetheine attachment site 6 71 3.6E-9 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS29365 92d35c3cb68739d08365c954de45129d 272 Gene3D G3DSA:3.60.20.10 3 235 9.1E-85 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS29365 92d35c3cb68739d08365c954de45129d 272 Hamap MF_00289_B Proteasome subunit alpha [prcA]. 1 234 49.204 T 09-03-2017 IPR022296 Proteasome, alpha subunit, bacterial GO:0004298|GO:0019773|GO:0051603 TK78_RS29365 92d35c3cb68739d08365c954de45129d 272 TIGRFAM TIGR03691 20S_bact_alpha: proteasome, alpha subunit 2 230 2.1E-115 T 09-03-2017 IPR022296 Proteasome, alpha subunit, bacterial GO:0004298|GO:0019773|GO:0051603 TK78_RS29365 92d35c3cb68739d08365c954de45129d 272 SUPERFAMILY SSF56235 10 230 2.85E-44 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS29365 92d35c3cb68739d08365c954de45129d 272 Pfam PF00227 Proteasome subunit 25 188 2.2E-28 T 09-03-2017 IPR001353 Proteasome, subunit alpha/beta GO:0004298|GO:0005839|GO:0051603 Reactome: R-HSA-1169091|Reactome: R-HSA-1236974|Reactome: R-HSA-1236978|Reactome: R-HSA-174084|Reactome: R-HSA-174113|Reactome: R-HSA-174154|Reactome: R-HSA-174178|Reactome: R-HSA-174184|Reactome: R-HSA-180534|Reactome: R-HSA-180585|Reactome: R-HSA-187577|Reactome: R-HSA-195253|Reactome: R-HSA-202424|Reactome: R-HSA-211733|Reactome: R-HSA-2467813|Reactome: R-HSA-2871837|Reactome: R-HSA-349425|Reactome: R-HSA-350562|Reactome: R-HSA-450408|Reactome: R-HSA-4608870|Reactome: R-HSA-4641257|Reactome: R-HSA-4641258|Reactome: R-HSA-5358346|Reactome: R-HSA-5362768|Reactome: R-HSA-5607761|Reactome: R-HSA-5607764|Reactome: R-HSA-5610780|Reactome: R-HSA-5610783|Reactome: R-HSA-5610785|Reactome: R-HSA-5632684|Reactome: R-HSA-5658442|Reactome: R-HSA-5668541|Reactome: R-HSA-5676590|Reactome: R-HSA-5687128|Reactome: R-HSA-68827|Reactome: R-HSA-68949|Reactome: R-HSA-69017|Reactome: R-HSA-69229|Reactome: R-HSA-69481|Reactome: R-HSA-69601|Reactome: R-HSA-8852276|Reactome: R-HSA-983168 TK78_RS00990 ac27854ee6ccbc3a953d0a6154db4347 191 Pfam PF02342 TerD domain 1 187 9.0E-86 T 09-03-2017 IPR003325 TerD domain GO:0006950 TK78_RS00990 ac27854ee6ccbc3a953d0a6154db4347 191 Gene3D G3DSA:2.60.60.30 18 184 1.4E-74 T 09-03-2017 TK78_RS16415 1493e7229b17e2a9b9f0c936b7a66a58 107 Gene3D G3DSA:1.10.1660.10 21 98 1.4E-10 T 09-03-2017 TK78_RS16415 1493e7229b17e2a9b9f0c936b7a66a58 107 SMART SM00422 21 89 8.4E-4 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS16415 1493e7229b17e2a9b9f0c936b7a66a58 107 SUPERFAMILY SSF46955 21 98 1.19E-9 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS16415 1493e7229b17e2a9b9f0c936b7a66a58 107 Pfam PF13411 MerR HTH family regulatory protein 21 82 3.0E-7 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS13605 cd3bb0102b2067d898c165a425dbab76 523 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 401 427 3.9E-30 T 09-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13605 cd3bb0102b2067d898c165a425dbab76 523 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 186 210 3.9E-30 T 09-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13605 cd3bb0102b2067d898c165a425dbab76 523 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 145 164 3.9E-30 T 09-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13605 cd3bb0102b2067d898c165a425dbab76 523 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 349 368 3.9E-30 T 09-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13605 cd3bb0102b2067d898c165a425dbab76 523 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 261 285 3.9E-30 T 09-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13605 cd3bb0102b2067d898c165a425dbab76 523 TIGRFAM TIGR01972 NDH_I_M: proton-translocating NADH-quinone oxidoreductase, chain M 6 509 4.3E-174 T 09-03-2017 IPR010227 NADH-quinone oxidoreductase, chain M/4 GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13605 cd3bb0102b2067d898c165a425dbab76 523 Pfam PF00361 Proton-conducting membrane transporter 139 443 1.6E-65 T 09-03-2017 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS11845 4d504f424c20f3b4a594a2fefe5db743 329 ProSitePatterns PS00211 ABC transporters family signature. 136 150 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS11845 4d504f424c20f3b4a594a2fefe5db743 329 Pfam PF00005 ABC transporter 22 163 3.8E-27 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS11845 4d504f424c20f3b4a594a2fefe5db743 329 SMART SM00382 29 218 1.0E-8 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS11845 4d504f424c20f3b4a594a2fefe5db743 329 SUPERFAMILY SSF52540 5 225 5.72E-60 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS11845 4d504f424c20f3b4a594a2fefe5db743 329 Gene3D G3DSA:3.40.50.300 3 231 5.4E-69 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS11845 4d504f424c20f3b4a594a2fefe5db743 329 TIGRFAM TIGR01188 drrA: daunorubicin resistance ABC transporter, ATP-binding protein 12 309 3.9E-109 T 09-03-2017 IPR005894 Daunorubicin resistance ABC transporter ATP-binding subunit DrrA GO:0005524|GO:0043215|GO:1900753 TK78_RS11845 4d504f424c20f3b4a594a2fefe5db743 329 Pfam PF13732 Domain of unknown function (DUF4162) 217 307 5.3E-8 T 09-03-2017 IPR025302 Domain of unknown function DUF4162 TK78_RS23340 b542db0aed242ad480356293e24271c0 509 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 16 38 1.8E-43 T 09-03-2017 TK78_RS23340 b542db0aed242ad480356293e24271c0 509 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 304 320 1.8E-43 T 09-03-2017 TK78_RS23340 b542db0aed242ad480356293e24271c0 509 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 289 304 1.8E-43 T 09-03-2017 TK78_RS23340 b542db0aed242ad480356293e24271c0 509 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 322 340 1.8E-43 T 09-03-2017 TK78_RS23340 b542db0aed242ad480356293e24271c0 509 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 165 180 1.8E-43 T 09-03-2017 TK78_RS23340 b542db0aed242ad480356293e24271c0 509 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 340 356 1.8E-43 T 09-03-2017 TK78_RS23340 b542db0aed242ad480356293e24271c0 509 SUPERFAMILY SSF51905 14 186 1.09E-57 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS23340 b542db0aed242ad480356293e24271c0 509 SUPERFAMILY SSF51905 276 365 1.09E-57 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS23340 b542db0aed242ad480356293e24271c0 509 Gene3D G3DSA:3.50.50.60 277 360 6.4E-54 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS23340 b542db0aed242ad480356293e24271c0 509 Gene3D G3DSA:3.50.50.60 14 191 6.4E-54 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS23340 b542db0aed242ad480356293e24271c0 509 Pfam PF01494 FAD binding domain 14 353 1.3E-72 T 09-03-2017 IPR002938 FAD-binding domain GO:0071949 TK78_RS03265 9e6c398c2fb1fa8d94ccf6b64c4670d0 244 SUPERFAMILY SSF53056 44 243 1.11E-41 T 09-03-2017 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 TK78_RS03265 9e6c398c2fb1fa8d94ccf6b64c4670d0 244 SMART SM00947 87 244 2.5E-38 T 09-03-2017 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 TK78_RS03265 9e6c398c2fb1fa8d94ccf6b64c4670d0 244 Gene3D G3DSA:3.40.1050.10 44 241 2.5E-46 T 09-03-2017 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 TK78_RS03265 9e6c398c2fb1fa8d94ccf6b64c4670d0 244 Pfam PF00484 Carbonic anhydrase 94 237 2.7E-32 T 09-03-2017 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 TK78_RS21105 dd893d48c65777673ff20048df2f8898 283 SUPERFAMILY SSF103481 186 281 4.71E-8 T 09-03-2017 TK78_RS21105 dd893d48c65777673ff20048df2f8898 283 Pfam PF00892 EamA-like transporter family 146 280 3.0E-10 T 09-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 TK78_RS21105 dd893d48c65777673ff20048df2f8898 283 SUPERFAMILY SSF103481 38 135 8.5E-11 T 09-03-2017 TK78_RS25580 37043d3ac9ead90d94eab85d9f310873 217 Gene3D G3DSA:1.10.357.10 64 211 2.6E-27 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS25580 37043d3ac9ead90d94eab85d9f310873 217 SUPERFAMILY SSF46689 11 93 3.49E-18 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS25580 37043d3ac9ead90d94eab85d9f310873 217 Gene3D G3DSA:1.10.10.60 8 63 1.4E-20 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS25580 37043d3ac9ead90d94eab85d9f310873 217 Pfam PF00440 Bacterial regulatory proteins, tetR family 25 66 2.5E-15 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS25580 37043d3ac9ead90d94eab85d9f310873 217 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 25 38 1.2E-6 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS25580 37043d3ac9ead90d94eab85d9f310873 217 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 46 69 1.2E-6 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS10125 3659babb7216fc582cada485bcb9f476 321 Gene3D G3DSA:3.40.50.1820 170 260 2.7E-7 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS10125 3659babb7216fc582cada485bcb9f476 321 Gene3D G3DSA:3.40.50.1820 86 106 2.7E-7 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS10125 3659babb7216fc582cada485bcb9f476 321 SUPERFAMILY SSF53474 114 257 1.03E-8 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS10125 3659babb7216fc582cada485bcb9f476 321 Pfam PF06259 Alpha/beta hydrolase 99 261 1.1E-37 T 09-03-2017 IPR010427 Protein of unknown function DUF1023 TK78_RS12315 e3205910433184deb96f958ef9f88c4a 170 SUPERFAMILY SSF52402 3 146 1.09E-26 T 09-03-2017 TK78_RS12315 e3205910433184deb96f958ef9f88c4a 170 Gene3D G3DSA:3.40.50.620 3 145 4.0E-27 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS12315 e3205910433184deb96f958ef9f88c4a 170 Pfam PF00582 Universal stress protein family 3 143 3.1E-22 T 09-03-2017 IPR006016 UspA GO:0006950 TK78_RS12315 e3205910433184deb96f958ef9f88c4a 170 PRINTS PR01438 Universal stress protein signature 103 115 1.1E-7 T 09-03-2017 IPR006015 Universal stress protein A TK78_RS12315 e3205910433184deb96f958ef9f88c4a 170 PRINTS PR01438 Universal stress protein signature 2 20 1.1E-7 T 09-03-2017 IPR006015 Universal stress protein A TK78_RS12315 e3205910433184deb96f958ef9f88c4a 170 PRINTS PR01438 Universal stress protein signature 121 143 1.1E-7 T 09-03-2017 IPR006015 Universal stress protein A TK78_RS13760 040d3b2513ea344db90b62a129cf1611 67 SMART SM00357 3 67 3.9E-30 T 09-03-2017 IPR011129 Cold shock protein GO:0003676 TK78_RS13760 040d3b2513ea344db90b62a129cf1611 67 PRINTS PR00050 Cold shock protein signature 25 34 8.6E-18 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS13760 040d3b2513ea344db90b62a129cf1611 67 PRINTS PR00050 Cold shock protein signature 4 19 8.6E-18 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS13760 040d3b2513ea344db90b62a129cf1611 67 PRINTS PR00050 Cold shock protein signature 40 58 8.6E-18 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS13760 040d3b2513ea344db90b62a129cf1611 67 SUPERFAMILY SSF50249 1 66 1.48E-25 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS13760 040d3b2513ea344db90b62a129cf1611 67 PIRSF PIRSF002599 1 67 1.9E-25 T 09-03-2017 IPR012156 Cold shock, CspA GO:0003676 TK78_RS13760 040d3b2513ea344db90b62a129cf1611 67 ProSitePatterns PS00352 'Cold-shock' domain signature. 15 34 - T 09-03-2017 IPR019844 Cold-shock conserved site TK78_RS13760 040d3b2513ea344db90b62a129cf1611 67 Pfam PF00313 'Cold-shock' DNA-binding domain 3 66 2.0E-31 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS13760 040d3b2513ea344db90b62a129cf1611 67 Gene3D G3DSA:2.40.50.140 1 65 7.3E-32 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS28825 09532faad27a9c9410715628993dd708 324 SMART SM00062 73 306 1.2E-29 T 09-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF TK78_RS28825 09532faad27a9c9410715628993dd708 324 Gene3D G3DSA:3.40.190.10 70 152 1.0E-24 T 09-03-2017 TK78_RS28825 09532faad27a9c9410715628993dd708 324 Gene3D G3DSA:3.40.190.10 266 303 1.0E-24 T 09-03-2017 TK78_RS28825 09532faad27a9c9410715628993dd708 324 Gene3D G3DSA:3.40.190.10 153 256 5.6E-25 T 09-03-2017 TK78_RS28825 09532faad27a9c9410715628993dd708 324 SUPERFAMILY SSF53850 63 304 3.07E-45 T 09-03-2017 TK78_RS28825 09532faad27a9c9410715628993dd708 324 SUPERFAMILY SSF53850 7 24 3.07E-45 T 09-03-2017 TK78_RS28825 09532faad27a9c9410715628993dd708 324 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3 76 303 3.9E-44 T 09-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF TK78_RS14270 eb394eaa66f98c58ae01752d8321c3f9 123 Pfam PF05331 Protein of unknown function (DUF742) 11 123 2.6E-38 T 09-03-2017 IPR007995 Protein of unknown function DUF742 TK78_RS03485 a2770ca6d2d86ca29854e70e535fd74f 339 TIGRFAM TIGR00996 Mtu_fam_mce: virulence factor Mce family protein 14 293 3.0E-58 T 09-03-2017 IPR005693 Virulence factor Mce protein TK78_RS03485 a2770ca6d2d86ca29854e70e535fd74f 339 PRINTS PR01782 Mycobacterial cell entry (MCE) protein signature 130 154 5.6E-10 T 09-03-2017 IPR005693 Virulence factor Mce protein TK78_RS03485 a2770ca6d2d86ca29854e70e535fd74f 339 PRINTS PR01782 Mycobacterial cell entry (MCE) protein signature 30 50 5.6E-10 T 09-03-2017 IPR005693 Virulence factor Mce protein TK78_RS03485 a2770ca6d2d86ca29854e70e535fd74f 339 PRINTS PR01782 Mycobacterial cell entry (MCE) protein signature 179 197 5.6E-10 T 09-03-2017 IPR005693 Virulence factor Mce protein TK78_RS03485 a2770ca6d2d86ca29854e70e535fd74f 339 PRINTS PR01782 Mycobacterial cell entry (MCE) protein signature 299 318 5.6E-10 T 09-03-2017 IPR005693 Virulence factor Mce protein TK78_RS03485 a2770ca6d2d86ca29854e70e535fd74f 339 PRINTS PR01782 Mycobacterial cell entry (MCE) protein signature 92 108 5.6E-10 T 09-03-2017 IPR005693 Virulence factor Mce protein TK78_RS03485 a2770ca6d2d86ca29854e70e535fd74f 339 Pfam PF02470 MlaD protein 41 114 1.3E-14 T 09-03-2017 IPR003399 Mce/MlaD TK78_RS06395 622b9a7c6b8fbaea92e2aaae6662ad3e 276 Gene3D G3DSA:3.40.630.30 142 270 1.4E-16 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS06395 622b9a7c6b8fbaea92e2aaae6662ad3e 276 SUPERFAMILY SSF55729 148 272 2.44E-15 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS06395 622b9a7c6b8fbaea92e2aaae6662ad3e 276 Pfam PF08445 FR47-like protein 209 270 2.8E-7 T 09-03-2017 IPR013653 FR47-like GO:0016747 TK78_RS28710 a04bf9379a6919138d26207afe694368 120 Pfam PF06993 Protein of unknown function (DUF1304) 10 117 8.4E-42 T 09-03-2017 IPR009732 Protein of unknown function DUF1304 TK78_RS10795 7cfe889d18ae5be0dad91fe403c6eed2 55 Pfam PF11314 Protein of unknown function (DUF3117) 4 53 2.9E-29 T 09-03-2017 IPR021465 Protein of unknown function DUF3117 TK78_RS00720 9aab2ad367373afe7b3611159a4c585a 284 SUPERFAMILY SSF110710 6 280 1.23E-84 T 09-03-2017 TK78_RS00720 9aab2ad367373afe7b3611159a4c585a 284 Pfam PF02522 Aminoglycoside 3-N-acetyltransferase 35 277 3.5E-72 T 09-03-2017 IPR003679 Aminoglycoside N(3)-acetyltransferase GO:0046353|GO:0046677 TK78_RS19580 7d0c0b35012c2c9f00e8460159ec4329 475 Gene3D G3DSA:3.40.640.10 86 334 3.9E-26 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS19580 7d0c0b35012c2c9f00e8460159ec4329 475 TIGRFAM TIGR01788 Glu-decarb-GAD: glutamate decarboxylase 36 455 4.5E-188 T 09-03-2017 IPR010107 Glutamate decarboxylase GO:0004351|GO:0006536|GO:0030170 KEGG: 00250+4.1.1.15|KEGG: 00410+4.1.1.15|KEGG: 00430+4.1.1.15|KEGG: 00650+4.1.1.15|MetaCyc: PWY-4321 TK78_RS19580 7d0c0b35012c2c9f00e8460159ec4329 475 SUPERFAMILY SSF53383 35 457 4.79E-123 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS19580 7d0c0b35012c2c9f00e8460159ec4329 475 Pfam PF00282 Pyridoxal-dependent decarboxylase conserved domain 60 389 1.6E-69 T 09-03-2017 IPR002129 Pyridoxal phosphate-dependent decarboxylase GO:0016831|GO:0019752|GO:0030170 TK78_RS34135 473f6130eb732d156f3bd1ff3c55cd59 315 Pfam PF12172 Rubredoxin-like zinc ribbon domain (DUF35_N) 189 220 1.2E-8 T 09-03-2017 IPR022002 Domain of unknown function DUF35, rubredoxin-like zinc ribbon domain, N-terminal TK78_RS34135 473f6130eb732d156f3bd1ff3c55cd59 315 SUPERFAMILY SSF50249 3 136 8.39E-26 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS34135 473f6130eb732d156f3bd1ff3c55cd59 315 Pfam PF01796 DUF35 OB-fold domain, acyl-CoA-associated 225 288 1.1E-12 T 09-03-2017 IPR002878 Domain of unknown function DUF35, OB-fold, C-terminal TK78_RS34135 473f6130eb732d156f3bd1ff3c55cd59 315 Pfam PF01796 DUF35 OB-fold domain, acyl-CoA-associated 64 127 1.6E-11 T 09-03-2017 IPR002878 Domain of unknown function DUF35, OB-fold, C-terminal TK78_RS34135 473f6130eb732d156f3bd1ff3c55cd59 315 SUPERFAMILY SSF50249 162 290 4.28E-30 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS32475 6d8e9000470c47d72e9b9cbccc641764 261 Gene3D G3DSA:3.40.50.720 9 253 1.6E-85 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS32475 6d8e9000470c47d72e9b9cbccc641764 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 133 149 3.2E-44 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS32475 6d8e9000470c47d72e9b9cbccc641764 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 181 198 3.2E-44 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS32475 6d8e9000470c47d72e9b9cbccc641764 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 160 179 3.2E-44 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS32475 6d8e9000470c47d72e9b9cbccc641764 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 217 237 3.2E-44 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS32475 6d8e9000470c47d72e9b9cbccc641764 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 84 95 3.2E-44 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS32475 6d8e9000470c47d72e9b9cbccc641764 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 15 32 3.2E-44 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS32475 6d8e9000470c47d72e9b9cbccc641764 261 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 139 147 1.3E-9 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS32475 6d8e9000470c47d72e9b9cbccc641764 261 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 160 179 1.3E-9 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS32475 6d8e9000470c47d72e9b9cbccc641764 261 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 84 95 1.3E-9 T 09-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR TK78_RS32475 6d8e9000470c47d72e9b9cbccc641764 261 SUPERFAMILY SSF51735 13 253 1.41E-79 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS32475 6d8e9000470c47d72e9b9cbccc641764 261 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 20 253 1.8E-69 T 09-03-2017 TK78_RS10805 9d5fe48f369a00605b697e3ea6a53746 197 SUPERFAMILY SSF48150 12 190 1.73E-65 T 09-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 TK78_RS10805 9d5fe48f369a00605b697e3ea6a53746 197 Gene3D G3DSA:1.10.340.30 13 190 2.3E-69 T 09-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 TK78_RS10805 9d5fe48f369a00605b697e3ea6a53746 197 Pfam PF03352 Methyladenine glycosylase 16 188 1.4E-64 T 09-03-2017 IPR005019 Methyladenine glycosylase GO:0006284|GO:0008725 TK78_RS01635 e060524e28c47c334fc6208cee43f307 378 Pfam PF13439 Glycosyltransferase Family 4 12 171 1.3E-27 T 09-03-2017 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 TK78_RS01635 e060524e28c47c334fc6208cee43f307 378 Pfam PF00534 Glycosyl transferases group 1 183 340 3.7E-21 T 09-03-2017 IPR001296 Glycosyl transferase, family 1 TK78_RS01635 e060524e28c47c334fc6208cee43f307 378 Gene3D G3DSA:3.40.50.2000 151 335 3.3E-27 T 09-03-2017 TK78_RS01635 e060524e28c47c334fc6208cee43f307 378 SUPERFAMILY SSF53756 4 363 9.81E-69 T 09-03-2017 TK78_RS05180 b207d9f15eaa3060e2185a260bc5df59 360 Gene3D G3DSA:3.40.190.10 141 227 5.7E-18 T 09-03-2017 TK78_RS05180 b207d9f15eaa3060e2185a260bc5df59 360 Pfam PF09084 NMT1/THI5 like 100 212 3.3E-13 T 09-03-2017 IPR015168 SsuA/THI5-like TK78_RS05180 b207d9f15eaa3060e2185a260bc5df59 360 SUPERFAMILY SSF53850 88 280 2.86E-27 T 09-03-2017 TK78_RS28785 914cf7d19ebe2d1487b39c3cf2a7ba01 406 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 145 240 6.4E-25 T 09-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 TK78_RS28785 914cf7d19ebe2d1487b39c3cf2a7ba01 406 Gene3D G3DSA:1.20.140.10 240 402 5.5E-39 T 09-03-2017 TK78_RS28785 914cf7d19ebe2d1487b39c3cf2a7ba01 406 SUPERFAMILY SSF56645 15 251 1.2E-76 T 09-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 TK78_RS28785 914cf7d19ebe2d1487b39c3cf2a7ba01 406 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 252 399 6.9E-29 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS28785 914cf7d19ebe2d1487b39c3cf2a7ba01 406 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 30 141 1.5E-28 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS28785 914cf7d19ebe2d1487b39c3cf2a7ba01 406 SUPERFAMILY SSF47203 252 402 2.42E-39 T 09-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TK78_RS28785 914cf7d19ebe2d1487b39c3cf2a7ba01 406 Gene3D G3DSA:1.10.540.10 13 143 1.0E-37 T 09-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 TK78_RS28785 914cf7d19ebe2d1487b39c3cf2a7ba01 406 Gene3D G3DSA:2.40.110.10 144 239 9.2E-37 T 09-03-2017 TK78_RS05860 cc341b2f7fafb59a07975b92127a1663 224 Gene3D G3DSA:3.60.160.10 32 217 1.4E-39 T 09-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 TK78_RS05860 cc341b2f7fafb59a07975b92127a1663 224 SUPERFAMILY SSF51219 32 217 1.54E-43 T 09-03-2017 IPR016031 Tryptophan RNA-binding attenuator protein-like domain TK78_RS05860 cc341b2f7fafb59a07975b92127a1663 224 Pfam PF01987 Mitochondrial biogenesis AIM24 33 214 2.7E-31 T 09-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 TK78_RS33495 bf57fd742ba52e83849249c3a597f2a8 175 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 1 147 2.2E-18 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS23675 f2c34cb8c69cda4b14730ba842d02af0 149 SMART SM00530 41 96 9.5E-8 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS23675 f2c34cb8c69cda4b14730ba842d02af0 149 Pfam PF13560 Helix-turn-helix domain 37 90 1.4E-11 T 09-03-2017 TK78_RS23675 f2c34cb8c69cda4b14730ba842d02af0 149 Gene3D G3DSA:1.10.260.40 38 90 8.4E-14 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS23675 f2c34cb8c69cda4b14730ba842d02af0 149 SUPERFAMILY SSF47413 30 90 5.35E-13 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS27605 c37ccdc7f6f8e2c38e6f27880a791a27 238 PIRSF PIRSF039137 1 238 3.0E-111 T 09-03-2017 IPR030660 High-affinity branched-chain amino acid transport ATP-binding protein GO:0015658|GO:0015803 TK78_RS27605 c37ccdc7f6f8e2c38e6f27880a791a27 238 ProSitePatterns PS00211 ABC transporters family signature. 138 152 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS27605 c37ccdc7f6f8e2c38e6f27880a791a27 238 Pfam PF00005 ABC transporter 21 165 9.3E-30 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS27605 c37ccdc7f6f8e2c38e6f27880a791a27 238 SUPERFAMILY SSF52540 4 236 6.41E-60 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27605 c37ccdc7f6f8e2c38e6f27880a791a27 238 Gene3D G3DSA:3.40.50.300 3 232 1.4E-62 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS27605 c37ccdc7f6f8e2c38e6f27880a791a27 238 SMART SM00382 29 231 3.1E-8 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS25305 dee43a0e86aee26a4e81aeeb772cf13e 201 Pfam PF09485 CRISPR-associated protein Cse2 (CRISPR_cse2) 38 188 1.3E-32 T 09-03-2017 IPR013382 CRISPR-associated protein Cse2 TK78_RS25305 dee43a0e86aee26a4e81aeeb772cf13e 201 TIGRFAM TIGR02548 casB_cse2: CRISPR type I-E/ECOLI-associated protein CasB/Cse2 33 189 2.9E-30 T 09-03-2017 IPR013382 CRISPR-associated protein Cse2 TK78_RS00340 f411cc7f79c1f5603f470277ff0f6543 42 Pfam PF01609 Transposase DDE domain 3 40 2.2E-9 T 09-03-2017 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 TK78_RS03075 e5d52475ac4d598ee234891e6d1b7fe1 317 Pfam PF13516 Leucine Rich repeat 238 256 0.012 T 09-03-2017 IPR001611 Leucine-rich repeat GO:0005515 TK78_RS03075 e5d52475ac4d598ee234891e6d1b7fe1 317 Gene3D G3DSA:3.80.10.10 34 299 8.5E-61 T 09-03-2017 IPR032675 Leucine-rich repeat domain, L domain-like TK78_RS03075 e5d52475ac4d598ee234891e6d1b7fe1 317 SUPERFAMILY SSF52047 149 277 5.23E-11 T 09-03-2017 TK78_RS13830 061e4f0680e920877ef8b9786adc5cd6 161 Pfam PF04075 Domain of unknown function (DUF385) 35 156 1.1E-24 T 09-03-2017 IPR004378 Deazaflavin-dependent nitroreductase/F420H(2)-dependent quinone reductase GO:0016491|GO:0055114 TK78_RS13830 061e4f0680e920877ef8b9786adc5cd6 161 TIGRFAM TIGR00026 hi_GC_TIGR00026: deazaflavin-dependent oxidoreductase, nitroreductase family 46 159 1.3E-23 T 09-03-2017 IPR004378 Deazaflavin-dependent nitroreductase/F420H(2)-dependent quinone reductase GO:0016491|GO:0055114 TK78_RS13300 a1c44ac7ebf8ef9daef44b92c8454ef0 236 SUPERFAMILY SSF103473 3 211 7.59E-31 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS13300 a1c44ac7ebf8ef9daef44b92c8454ef0 236 Gene3D G3DSA:1.20.1250.20 11 205 2.0E-27 T 09-03-2017 TK78_RS13300 a1c44ac7ebf8ef9daef44b92c8454ef0 236 Pfam PF07690 Major Facilitator Superfamily 3 156 8.8E-17 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS17780 1b61c13b89c3d7e8ef76758fea53b2c9 605 Pfam PF13905 Thioredoxin-like 33 127 3.5E-12 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS17780 1b61c13b89c3d7e8ef76758fea53b2c9 605 SUPERFAMILY SSF101898 163 468 2.22E-37 T 09-03-2017 TK78_RS17780 1b61c13b89c3d7e8ef76758fea53b2c9 605 SUPERFAMILY SSF52833 20 153 1.21E-30 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS17780 1b61c13b89c3d7e8ef76758fea53b2c9 605 Pfam PF01436 NHL repeat 342 368 2.8E-4 T 09-03-2017 IPR001258 NHL repeat GO:0005515 TK78_RS17780 1b61c13b89c3d7e8ef76758fea53b2c9 605 Pfam PF01436 NHL repeat 399 426 3.9E-4 T 09-03-2017 IPR001258 NHL repeat GO:0005515 TK78_RS17780 1b61c13b89c3d7e8ef76758fea53b2c9 605 Pfam PF01436 NHL repeat 229 254 6.1E-6 T 09-03-2017 IPR001258 NHL repeat GO:0005515 TK78_RS17780 1b61c13b89c3d7e8ef76758fea53b2c9 605 Gene3D G3DSA:3.40.30.10 10 151 7.4E-40 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS17780 1b61c13b89c3d7e8ef76758fea53b2c9 605 Gene3D G3DSA:2.120.10.30 173 471 1.0E-48 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS32840 5c090e84b92b6b0332148a5bd04bb855 377 Gene3D G3DSA:3.40.50.1100 166 357 1.2E-34 T 09-03-2017 TK78_RS32840 5c090e84b92b6b0332148a5bd04bb855 377 SUPERFAMILY SSF53686 45 358 6.55E-69 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS32840 5c090e84b92b6b0332148a5bd04bb855 377 Gene3D G3DSA:3.40.50.1100 69 165 9.7E-23 T 09-03-2017 TK78_RS32840 5c090e84b92b6b0332148a5bd04bb855 377 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 49 337 9.8E-47 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS31160 09ef19cc4303329500342fc60212d912 241 SUPERFAMILY SSF102114 33 129 1.83E-13 T 09-03-2017 TK78_RS31160 09ef19cc4303329500342fc60212d912 241 Pfam PF13394 4Fe-4S single cluster domain 31 126 8.2E-12 T 09-03-2017 TK78_RS31160 09ef19cc4303329500342fc60212d912 241 Hamap MF_00917 7-carboxy-7-deazaguanine synthase [queE]. 9 238 38.022 T 09-03-2017 IPR024924 7-carboxy-7-deazaguanine synthase-like KEGG: 00790+4.3.99.3|MetaCyc: PWY-6703 TK78_RS31160 09ef19cc4303329500342fc60212d912 241 PIRSF PIRSF000370 7 241 1.8E-47 T 09-03-2017 IPR024924 7-carboxy-7-deazaguanine synthase-like KEGG: 00790+4.3.99.3|MetaCyc: PWY-6703 TK78_RS31160 09ef19cc4303329500342fc60212d912 241 Gene3D G3DSA:3.20.20.70 36 129 3.9E-14 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS31160 09ef19cc4303329500342fc60212d912 241 Pfam PF04055 Radical SAM superfamily 35 129 3.7E-10 T 09-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 TK78_RS12480 e8d4778ab12bb6b466a4129e9d4c23fe 214 Pfam PF06271 RDD family 85 205 1.9E-22 T 09-03-2017 IPR010432 RDD TK78_RS12480 e8d4778ab12bb6b466a4129e9d4c23fe 214 SUPERFAMILY SSF81995 7 77 5.49E-5 T 09-03-2017 TK78_RS29020 d50703f6de20ceeedb7481f1d52e9510 317 SUPERFAMILY SSF103481 45 142 1.14E-12 T 09-03-2017 TK78_RS29020 d50703f6de20ceeedb7481f1d52e9510 317 Pfam PF00892 EamA-like transporter family 13 140 5.9E-19 T 09-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 TK78_RS29020 d50703f6de20ceeedb7481f1d52e9510 317 Pfam PF00892 EamA-like transporter family 153 286 3.9E-21 T 09-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 TK78_RS29020 d50703f6de20ceeedb7481f1d52e9510 317 SUPERFAMILY SSF103481 189 289 8.37E-14 T 09-03-2017 TK78_RS17175 8bc4541fcf45f6e7ad487442cef4ce08 150 Pfam PF00583 Acetyltransferase (GNAT) family 58 140 4.3E-13 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS17175 8bc4541fcf45f6e7ad487442cef4ce08 150 SUPERFAMILY SSF55729 1 144 5.82E-29 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS17175 8bc4541fcf45f6e7ad487442cef4ce08 150 Gene3D G3DSA:3.40.630.30 1 149 2.3E-42 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS14960 5b86f999990ae0b8f7735925ddf30483 188 SUPERFAMILY SSF55729 16 175 6.42E-20 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS14960 5b86f999990ae0b8f7735925ddf30483 188 Pfam PF00583 Acetyltransferase (GNAT) family 91 160 4.3E-6 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS14960 5b86f999990ae0b8f7735925ddf30483 188 Gene3D G3DSA:3.40.630.30 17 186 3.7E-36 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS09870 58c920d935b803cc04a3801902a326da 104 Pfam PF17032 zinc-ribbon family 18 73 1.7E-7 T 09-03-2017 IPR031493 Zinc-ribbon 15 TK78_RS22610 49d84f989694a41feb83c5e430d59959 346 Gene3D G3DSA:1.10.3470.10 15 341 1.7E-106 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS22610 49d84f989694a41feb83c5e430d59959 346 SUPERFAMILY SSF81345 10 340 9.02E-80 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS22610 49d84f989694a41feb83c5e430d59959 346 Pfam PF01032 FecCD transport family 24 339 3.2E-93 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS31075 7233cd4ef7db5350ce65d1d4296f3e55 280 Gene3D G3DSA:3.40.50.970 1 279 1.1E-84 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS31075 7233cd4ef7db5350ce65d1d4296f3e55 280 SUPERFAMILY SSF52518 1 278 1.24E-67 T 09-03-2017 IPR029061 Thiamin diphosphate-binding fold TK78_RS31075 7233cd4ef7db5350ce65d1d4296f3e55 280 Pfam PF00676 Dehydrogenase E1 component 1 270 4.8E-57 T 09-03-2017 IPR001017 Dehydrogenase, E1 component GO:0008152|GO:0016624 TK78_RS19345 ae36ef4d1b7f13a82ce6c086926c603c 466 Gene3D G3DSA:3.50.50.60 355 401 1.6E-35 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS19345 ae36ef4d1b7f13a82ce6c086926c603c 466 Gene3D G3DSA:3.50.50.60 181 252 1.6E-35 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS19345 ae36ef4d1b7f13a82ce6c086926c603c 466 Gene3D G3DSA:3.50.50.60 22 114 1.6E-35 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS19345 ae36ef4d1b7f13a82ce6c086926c603c 466 SUPERFAMILY SSF51905 182 308 1.33E-37 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS19345 ae36ef4d1b7f13a82ce6c086926c603c 466 SUPERFAMILY SSF51905 12 127 1.33E-37 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS19345 ae36ef4d1b7f13a82ce6c086926c603c 466 Gene3D G3DSA:3.30.9.10 129 180 7.5E-6 T 09-03-2017 TK78_RS19345 ae36ef4d1b7f13a82ce6c086926c603c 466 Gene3D G3DSA:3.30.9.10 253 351 7.5E-6 T 09-03-2017 TK78_RS19345 ae36ef4d1b7f13a82ce6c086926c603c 466 Pfam PF01266 FAD dependent oxidoreductase 34 393 6.6E-49 T 09-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 TK78_RS15350 195b76e09f14c70e96833bda64195c7c 322 Pfam PF00482 Type II secretion system (T2SS), protein F 148 275 5.2E-8 T 09-03-2017 IPR018076 Type II secretion system F domain TK78_RS30435 55112e94369d46110b196a966e17ce1d 409 Gene3D G3DSA:1.20.1250.20 213 385 8.3E-15 T 09-03-2017 TK78_RS30435 55112e94369d46110b196a966e17ce1d 409 Gene3D G3DSA:1.20.1250.20 20 188 2.7E-19 T 09-03-2017 TK78_RS30435 55112e94369d46110b196a966e17ce1d 409 Pfam PF07690 Major Facilitator Superfamily 25 350 3.5E-26 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS30435 55112e94369d46110b196a966e17ce1d 409 SUPERFAMILY SSF103473 16 388 1.2E-43 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS06650 7e7552fd0bc1b693c676ed7879826249 323 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 224 311 1.8E-24 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS06650 7e7552fd0bc1b693c676ed7879826249 323 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 226 290 5.7E-21 T 09-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TK78_RS06650 7e7552fd0bc1b693c676ed7879826249 323 ProSitePatterns PS00211 ABC transporters family signature. 147 161 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS06650 7e7552fd0bc1b693c676ed7879826249 323 SUPERFAMILY SSF52540 19 245 2.93E-57 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06650 7e7552fd0bc1b693c676ed7879826249 323 Gene3D G3DSA:3.40.50.300 6 248 1.2E-66 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06650 7e7552fd0bc1b693c676ed7879826249 323 SMART SM00382 33 224 7.9E-13 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS06650 7e7552fd0bc1b693c676ed7879826249 323 Pfam PF00005 ABC transporter 24 174 1.3E-19 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS08045 90a8018d45326f85b77498e0f15555fe 346 SUPERFAMILY SSF50331 237 337 4.68E-6 T 09-03-2017 IPR008995 Molybdate/tungstate binding, C-terminal TK78_RS08045 90a8018d45326f85b77498e0f15555fe 346 ProSitePatterns PS00211 ABC transporters family signature. 132 146 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS08045 90a8018d45326f85b77498e0f15555fe 346 Pfam PF00005 ABC transporter 17 159 5.7E-30 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS08045 90a8018d45326f85b77498e0f15555fe 346 SUPERFAMILY SSF52540 1 240 6.8E-77 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08045 90a8018d45326f85b77498e0f15555fe 346 Gene3D G3DSA:3.40.50.300 1 232 4.3E-72 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08045 90a8018d45326f85b77498e0f15555fe 346 Pfam PF08402 TOBE domain 267 337 2.4E-8 T 09-03-2017 IPR013611 Transport-associated OB, type 2 GO:0005215|GO:0005524|GO:0006810|GO:0016820|GO:0043190 TK78_RS08045 90a8018d45326f85b77498e0f15555fe 346 SMART SM00382 26 209 1.1E-17 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS19180 78229b93fc49ba2ceb45bfd43c0e925e 398 Pfam PF00668 Condensation domain 4 197 6.6E-7 T 09-03-2017 IPR001242 Condensation domain TK78_RS19180 78229b93fc49ba2ceb45bfd43c0e925e 398 SUPERFAMILY SSF52777 179 369 7.56E-10 T 09-03-2017 TK78_RS19180 78229b93fc49ba2ceb45bfd43c0e925e 398 SUPERFAMILY SSF52777 3 186 8.23E-11 T 09-03-2017 TK78_RS22355 82860835007deb91d51c0bba4d142596 93 Gene3D G3DSA:4.10.520.10 1 91 2.0E-28 T 09-03-2017 IPR010992 Integration host factor (IHF)-like DNA-binding domain GO:0003677 TK78_RS22355 82860835007deb91d51c0bba4d142596 93 SUPERFAMILY SSF47729 1 91 9.27E-26 T 09-03-2017 IPR010992 Integration host factor (IHF)-like DNA-binding domain GO:0003677 TK78_RS22355 82860835007deb91d51c0bba4d142596 93 ProSitePatterns PS00045 Bacterial histone-like DNA-binding proteins signature. 47 66 - T 09-03-2017 IPR020816 Histone-like DNA-binding protein, conserved site GO:0003677 TK78_RS22355 82860835007deb91d51c0bba4d142596 93 Pfam PF00216 Bacterial DNA-binding protein 1 90 3.9E-27 T 09-03-2017 IPR000119 Histone-like DNA-binding protein GO:0003677 TK78_RS22355 82860835007deb91d51c0bba4d142596 93 SMART SM00411 1 91 5.5E-38 T 09-03-2017 IPR000119 Histone-like DNA-binding protein GO:0003677 TK78_RS22355 82860835007deb91d51c0bba4d142596 93 PRINTS PR01727 Prokaryotic integration host factor signature 59 72 6.9E-8 T 09-03-2017 IPR000119 Histone-like DNA-binding protein GO:0003677 TK78_RS22355 82860835007deb91d51c0bba4d142596 93 PRINTS PR01727 Prokaryotic integration host factor signature 41 56 6.9E-8 T 09-03-2017 IPR000119 Histone-like DNA-binding protein GO:0003677 TK78_RS22355 82860835007deb91d51c0bba4d142596 93 PRINTS PR01727 Prokaryotic integration host factor signature 75 89 6.9E-8 T 09-03-2017 IPR000119 Histone-like DNA-binding protein GO:0003677 TK78_RS08880 9a367635dc182722761ffc25aa5b464c 179 SUPERFAMILY SSF102405 1 174 1.18E-41 T 09-03-2017 TK78_RS08880 9a367635dc182722761ffc25aa5b464c 179 Pfam PF03641 Possible lysine decarboxylase 44 169 2.1E-30 T 09-03-2017 IPR031100 LOG family TK78_RS08880 9a367635dc182722761ffc25aa5b464c 179 TIGRFAM TIGR00730 TIGR00730: TIGR00730 family protein 2 151 3.2E-34 T 09-03-2017 IPR005269 Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG TK78_RS08880 9a367635dc182722761ffc25aa5b464c 179 Gene3D G3DSA:3.40.50.450 1 174 2.2E-42 T 09-03-2017 TK78_RS06555 c167a26368ce5d167b4e8b0e5c303e48 352 SUPERFAMILY SSF53300 12 128 8.74E-8 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS06555 c167a26368ce5d167b4e8b0e5c303e48 352 Gene3D G3DSA:3.40.50.410 12 126 1.9E-5 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS16535 9e1b6ef65aaf019c320c5acad78a86c9 142 Gene3D G3DSA:3.40.140.10 1 140 3.5E-59 T 09-03-2017 TK78_RS16535 9e1b6ef65aaf019c320c5acad78a86c9 142 Hamap MF_00972 tRNA-specific adenosine deaminase [tadA]. 1 140 46.01 T 09-03-2017 IPR028883 tRNA-specific adenosine deaminase GO:0002100|GO:0008251 Reactome: R-HSA-6782315 TK78_RS16535 9e1b6ef65aaf019c320c5acad78a86c9 142 SUPERFAMILY SSF53927 1 140 5.69E-53 T 09-03-2017 IPR016193 Cytidine deaminase-like GO:0003824 TK78_RS16535 9e1b6ef65aaf019c320c5acad78a86c9 142 ProSitePatterns PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 47 84 - T 09-03-2017 IPR016192 APOBEC/CMP deaminase, zinc-binding GO:0008270|GO:0016787 TK78_RS16535 9e1b6ef65aaf019c320c5acad78a86c9 142 Pfam PF14437 MafB19-like deaminase 1 142 1.1E-33 T 09-03-2017 IPR028883 tRNA-specific adenosine deaminase GO:0002100|GO:0008251 Reactome: R-HSA-6782315 TK78_RS13755 f5753b0b7a9ff91bb508ed910ecdbe2c 293 Gene3D G3DSA:3.40.190.10 93 194 2.4E-37 T 09-03-2017 TK78_RS13755 f5753b0b7a9ff91bb508ed910ecdbe2c 293 Hamap MF_00995 Chorismate dehydratase [mqnA]. 20 282 31.201 T 09-03-2017 IPR030868 Chorismate dehydratase GO:0009234|GO:0016829 KEGG: 00130+4.2.1.151|MetaCyc: PWY-7371|MetaCyc: PWY-7374 TK78_RS13755 f5753b0b7a9ff91bb508ed910ecdbe2c 293 SUPERFAMILY SSF53850 19 275 2.64E-76 T 09-03-2017 TK78_RS13755 f5753b0b7a9ff91bb508ed910ecdbe2c 293 Pfam PF02621 Menaquinone biosynthesis 20 276 1.1E-70 T 09-03-2017 IPR003773 Menaquinone biosynthesis enzyme TK78_RS13755 f5753b0b7a9ff91bb508ed910ecdbe2c 293 Gene3D G3DSA:3.40.190.10 195 292 1.5E-67 T 09-03-2017 TK78_RS13755 f5753b0b7a9ff91bb508ed910ecdbe2c 293 Gene3D G3DSA:3.40.190.10 16 92 1.5E-67 T 09-03-2017 TK78_RS06845 1da65fb1d984868fbfc3a2b93baf59d6 442 SUPERFAMILY SSF50249 9 64 1.03E-8 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS06845 1da65fb1d984868fbfc3a2b93baf59d6 442 Gene3D G3DSA:3.40.50.150 244 436 1.1E-47 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS06845 1da65fb1d984868fbfc3a2b93baf59d6 442 SUPERFAMILY SSF53335 75 437 1.42E-55 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS06845 1da65fb1d984868fbfc3a2b93baf59d6 442 Gene3D G3DSA:2.40.50.140 10 85 3.6E-21 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS06845 1da65fb1d984868fbfc3a2b93baf59d6 442 ProSitePatterns PS01231 RNA methyltransferase trmA family signature 2. 420 430 - T 09-03-2017 IPR030391 RNA methyltransferase TrmA, conserved site TK78_RS06845 1da65fb1d984868fbfc3a2b93baf59d6 442 Pfam PF05958 tRNA (Uracil-5-)-methyltransferase 361 436 6.8E-11 T 09-03-2017 IPR010280 (Uracil-5)-methyltransferase family GO:0006396|GO:0008173 TK78_RS06845 1da65fb1d984868fbfc3a2b93baf59d6 442 Pfam PF01938 TRAM domain 8 67 1.6E-11 T 09-03-2017 IPR002792 TRAM domain TK78_RS05285 649992b371bae26773e56b20679f4e20 260 Gene3D G3DSA:1.25.40.10 61 233 5.2E-6 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS18810 8779515ba9079e020f20479e30c8dc15 349 Gene3D G3DSA:2.40.10.10 275 345 2.4E-39 T 09-03-2017 TK78_RS18810 8779515ba9079e020f20479e30c8dc15 349 Gene3D G3DSA:2.40.10.10 203 236 2.4E-39 T 09-03-2017 TK78_RS18810 8779515ba9079e020f20479e30c8dc15 349 PRINTS PR00834 HtrA/DegQ protease family signature 140 152 2.0E-26 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS18810 8779515ba9079e020f20479e30c8dc15 349 PRINTS PR00834 HtrA/DegQ protease family signature 275 292 2.0E-26 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS18810 8779515ba9079e020f20479e30c8dc15 349 PRINTS PR00834 HtrA/DegQ protease family signature 161 181 2.0E-26 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS18810 8779515ba9079e020f20479e30c8dc15 349 PRINTS PR00834 HtrA/DegQ protease family signature 297 314 2.0E-26 T 09-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TK78_RS18810 8779515ba9079e020f20479e30c8dc15 349 Gene3D G3DSA:2.40.10.10 127 202 3.2E-31 T 09-03-2017 TK78_RS18810 8779515ba9079e020f20479e30c8dc15 349 SUPERFAMILY SSF50494 273 346 2.22E-52 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS18810 8779515ba9079e020f20479e30c8dc15 349 SUPERFAMILY SSF50494 107 234 2.22E-52 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS18810 8779515ba9079e020f20479e30c8dc15 349 Pfam PF13365 Trypsin-like peptidase domain 131 304 5.0E-31 T 09-03-2017 TK78_RS20295 ee4f1cdb9572270f28555908581e259e 97 Pfam PF14012 Protein of unknown function (DUF4229) 10 81 2.8E-21 T 09-03-2017 IPR025323 Protein of unknown function DUF4229 TK78_RS20295 ee4f1cdb9572270f28555908581e259e 97 TIGRFAM TIGR01167 LPXTG_anchor: LPXTG cell wall anchor domain 41 68 8.1E-4 T 09-03-2017 IPR019931 LPXTG cell wall anchor domain TK78_RS27275 043ca809014814382fe31f9ff08e7b1c 135 SUPERFAMILY SSF55298 8 132 1.57E-25 T 09-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like TK78_RS27275 043ca809014814382fe31f9ff08e7b1c 135 Gene3D G3DSA:3.30.1330.40 8 133 6.2E-32 T 09-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like TK78_RS27275 043ca809014814382fe31f9ff08e7b1c 135 Pfam PF01042 Endoribonuclease L-PSP 22 129 2.2E-15 T 09-03-2017 IPR006175 YjgF/YER057c/UK114 family TK78_RS10290 760f2ff3639b06051bc42b652607bfab 335 Gene3D G3DSA:1.10.3720.10 36 323 6.7E-53 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS10290 760f2ff3639b06051bc42b652607bfab 335 SUPERFAMILY SSF161098 43 330 2.22E-47 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS10290 760f2ff3639b06051bc42b652607bfab 335 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 124 325 3.5E-15 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS06870 c53bf74ec7b89ecdde1d272ca94d9a72 116 Gene3D G3DSA:2.40.50.140 27 110 4.4E-9 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS06870 c53bf74ec7b89ecdde1d272ca94d9a72 116 PIRSF PIRSF006910 1 113 2.5E-48 T 09-03-2017 IPR016499 Nucleic acid binding protein, Rv2694c, predicted TK78_RS03650 bcd3e50c7557f45769ae89be19c2ebd0 218 Gene3D G3DSA:1.20.1260.10 50 214 4.0E-58 T 09-03-2017 IPR012347 Ferritin-related TK78_RS03650 bcd3e50c7557f45769ae89be19c2ebd0 218 Pfam PF03713 Domain of unknown function (DUF305) 56 211 1.1E-44 T 09-03-2017 IPR005183 Domain of unknown function DUF305 TK78_RS17820 aa9fa4e2129ffb3b7a0c29ebd87b3155 705 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 354 562 5.4E-51 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS17820 aa9fa4e2129ffb3b7a0c29ebd87b3155 705 Pfam PF13185 GAF domain 173 297 1.7E-11 T 09-03-2017 IPR003018 GAF domain GO:0005515 TK78_RS17820 aa9fa4e2129ffb3b7a0c29ebd87b3155 705 Gene3D G3DSA:3.60.40.10 470 560 1.1E-4 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS17820 aa9fa4e2129ffb3b7a0c29ebd87b3155 705 Pfam PF13581 Histidine kinase-like ATPase domain 582 692 1.6E-7 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS17820 aa9fa4e2129ffb3b7a0c29ebd87b3155 705 Gene3D G3DSA:3.30.450.40 142 300 4.7E-15 T 09-03-2017 IPR029016 GAF domain-like TK78_RS17820 aa9fa4e2129ffb3b7a0c29ebd87b3155 705 SUPERFAMILY SSF55781 179 309 2.62E-14 T 09-03-2017 IPR029016 GAF domain-like TK78_RS17820 aa9fa4e2129ffb3b7a0c29ebd87b3155 705 SUPERFAMILY SSF81606 341 562 1.24E-11 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS17820 aa9fa4e2129ffb3b7a0c29ebd87b3155 705 SMART SM00331 325 562 2.2E-39 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS17820 aa9fa4e2129ffb3b7a0c29ebd87b3155 705 Gene3D G3DSA:3.30.450.20 2 100 8.7E-8 T 09-03-2017 TK78_RS25655 5db4ed934875cbc1ee44d7f22d5ca8c6 70 Pfam PF09723 Zinc ribbon domain 1 40 4.6E-12 T 09-03-2017 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain TK78_RS25655 5db4ed934875cbc1ee44d7f22d5ca8c6 70 SMART SM00834 1 42 2.1E-12 T 09-03-2017 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain TK78_RS25655 5db4ed934875cbc1ee44d7f22d5ca8c6 70 Gene3D G3DSA:2.20.28.10 6 40 2.6E-4 T 09-03-2017 IPR004039 Rubredoxin-type fold TK78_RS25655 5db4ed934875cbc1ee44d7f22d5ca8c6 70 TIGRFAM TIGR02605 CxxC_CxxC_SSSS: putative regulatory protein, FmdB family 1 46 1.5E-16 T 09-03-2017 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain TK78_RS29345 e1ffb08cb8400360144720a4b80690a8 503 PIRSF PIRSF018077 10 500 1.1E-217 T 09-03-2017 IPR004347 Pup ligase/deamidase GO:0010498|GO:0019941 TK78_RS29345 e1ffb08cb8400360144720a4b80690a8 503 Pfam PF03136 Pup-ligase protein 5 457 1.1E-190 T 09-03-2017 IPR004347 Pup ligase/deamidase GO:0010498|GO:0019941 TK78_RS29345 e1ffb08cb8400360144720a4b80690a8 503 TIGRFAM TIGR03688 pupylate_PafA2: proteasome accessory factor PafA2 4 490 2.8E-244 T 09-03-2017 IPR022366 Pup deamidase GO:0008233|GO:0016811 TK78_RS05480 0c67fd151d7ec8893766968a5de4c7c2 238 PIRSF PIRSF000857 2 238 1.4E-90 T 09-03-2017 IPR004511 Phosphoadenosine phosphosulphate/adenosine 5'-phosphosulphate reductase GO:0004604|GO:0019379|GO:0055114 KEGG: 00920+1.8.4.8 TK78_RS05480 0c67fd151d7ec8893766968a5de4c7c2 238 TIGRFAM TIGR00434 cysH: phosophoadenylyl-sulfate reductase 31 237 7.6E-59 T 09-03-2017 IPR004511 Phosphoadenosine phosphosulphate/adenosine 5'-phosphosulphate reductase GO:0004604|GO:0019379|GO:0055114 KEGG: 00920+1.8.4.8 TK78_RS05480 0c67fd151d7ec8893766968a5de4c7c2 238 Pfam PF01507 Phosphoadenosine phosphosulfate reductase family 51 213 4.0E-40 T 09-03-2017 IPR002500 Phosphoadenosine phosphosulphate reductase GO:0003824|GO:0008152 Reactome: R-HSA-196843 TK78_RS05480 0c67fd151d7ec8893766968a5de4c7c2 238 SUPERFAMILY SSF52402 22 199 2.36E-44 T 09-03-2017 TK78_RS05480 0c67fd151d7ec8893766968a5de4c7c2 238 Gene3D G3DSA:3.40.50.620 9 210 1.7E-54 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS16575 8f207ba46b2f3493079b731fa08bd35c 106 Pfam PF13601 Winged helix DNA-binding domain 21 99 5.7E-17 T 09-03-2017 IPR027395 Winged helix DNA-binding domain TK78_RS16575 8f207ba46b2f3493079b731fa08bd35c 106 SUPERFAMILY SSF46785 15 98 9.1E-13 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS16575 8f207ba46b2f3493079b731fa08bd35c 106 Gene3D G3DSA:1.10.10.10 12 99 2.0E-20 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS06015 c8c34641bca9dd30470b8688820eac0b 316 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 124 309 3.5E-21 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS06015 c8c34641bca9dd30470b8688820eac0b 316 Gene3D G3DSA:1.10.3720.10 42 304 3.6E-62 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS06015 c8c34641bca9dd30470b8688820eac0b 316 SUPERFAMILY SSF161098 46 316 1.5E-69 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS12205 eb14c7a57e428b871152bd34b9139dcc 311 Gene3D G3DSA:3.20.20.70 11 277 1.8E-100 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS12205 eb14c7a57e428b871152bd34b9139dcc 311 Pfam PF03102 NeuB family 41 277 6.4E-82 T 09-03-2017 IPR013132 N-acetylneuraminic acid synthase, N-terminal GO:0016051 Reactome: R-HSA-4085001 TK78_RS12205 eb14c7a57e428b871152bd34b9139dcc 311 SUPERFAMILY SSF51569 11 290 1.22E-85 T 09-03-2017 TK78_RS05835 5e4bdd8793f91d4842e841babc0bf0c2 364 Gene3D G3DSA:3.40.50.300 31 225 1.2E-23 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS05835 5e4bdd8793f91d4842e841babc0bf0c2 364 Pfam PF03969 AFG1-like ATPase 258 355 1.7E-13 T 09-03-2017 IPR005654 ATPase, AFG1-like GO:0005524 TK78_RS05835 5e4bdd8793f91d4842e841babc0bf0c2 364 Pfam PF03969 AFG1-like ATPase 40 241 6.9E-41 T 09-03-2017 IPR005654 ATPase, AFG1-like GO:0005524 TK78_RS05835 5e4bdd8793f91d4842e841babc0bf0c2 364 SUPERFAMILY SSF52540 98 207 6.72E-8 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08930 2c708322fbb084d7eabbc669be1c235e 223 Pfam PF03458 UPF0126 domain 99 173 2.4E-20 T 09-03-2017 IPR005115 Uncharacterised domain UPF0126 TK78_RS08930 2c708322fbb084d7eabbc669be1c235e 223 Pfam PF03458 UPF0126 domain 13 87 2.9E-20 T 09-03-2017 IPR005115 Uncharacterised domain UPF0126 TK78_RS13305 ac92a0de9339408ac1aaf5a9da5f9db5 142 Pfam PF01575 MaoC like domain 15 112 1.3E-25 T 09-03-2017 IPR002539 MaoC-like domain TK78_RS13305 ac92a0de9339408ac1aaf5a9da5f9db5 142 SUPERFAMILY SSF54637 5 139 8.61E-29 T 09-03-2017 IPR029069 HotDog domain TK78_RS13305 ac92a0de9339408ac1aaf5a9da5f9db5 142 PRINTS PR01483 Fatty acid synthase signature 25 47 7.1E-8 T 09-03-2017 IPR003965 Fatty acid synthase GO:0004312|GO:0005835|GO:0006633|GO:0055114 TK78_RS13305 ac92a0de9339408ac1aaf5a9da5f9db5 142 PRINTS PR01483 Fatty acid synthase signature 47 68 7.1E-8 T 09-03-2017 IPR003965 Fatty acid synthase GO:0004312|GO:0005835|GO:0006633|GO:0055114 TK78_RS13305 ac92a0de9339408ac1aaf5a9da5f9db5 142 Gene3D G3DSA:3.10.129.10 9 141 1.6E-38 T 09-03-2017 IPR029069 HotDog domain TK78_RS11475 4584b0ffb6c9b24d7e3007df9d9ce42c 174 Pfam PF03551 Transcriptional regulator PadR-like family 7 76 2.2E-15 T 09-03-2017 IPR005149 Transcription regulator PadR, N-terminal TK78_RS11475 4584b0ffb6c9b24d7e3007df9d9ce42c 174 SUPERFAMILY SSF46785 3 168 2.04E-35 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS11475 4584b0ffb6c9b24d7e3007df9d9ce42c 174 Gene3D G3DSA:1.10.10.10 1 87 1.7E-26 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS15940 18640af5ae7aa35a6903df973210b016 401 Pfam PF00067 Cytochrome P450 191 373 1.7E-20 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS15940 18640af5ae7aa35a6903df973210b016 401 Gene3D G3DSA:1.10.630.10 4 400 2.5E-121 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS15940 18640af5ae7aa35a6903df973210b016 401 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 346 355 - T 09-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 TK78_RS15940 18640af5ae7aa35a6903df973210b016 401 SUPERFAMILY SSF48264 7 399 6.55E-91 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS15940 18640af5ae7aa35a6903df973210b016 401 PRINTS PR00359 B-class P450 signature 154 169 3.5E-56 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS15940 18640af5ae7aa35a6903df973210b016 401 PRINTS PR00359 B-class P450 signature 323 338 3.5E-56 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS15940 18640af5ae7aa35a6903df973210b016 401 PRINTS PR00359 B-class P450 signature 137 153 3.5E-56 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS15940 18640af5ae7aa35a6903df973210b016 401 PRINTS PR00359 B-class P450 signature 353 364 3.5E-56 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS15940 18640af5ae7aa35a6903df973210b016 401 PRINTS PR00359 B-class P450 signature 197 219 3.5E-56 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS15940 18640af5ae7aa35a6903df973210b016 401 PRINTS PR00359 B-class P450 signature 344 353 3.5E-56 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS15940 18640af5ae7aa35a6903df973210b016 401 PRINTS PR00359 B-class P450 signature 91 102 3.5E-56 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS15940 18640af5ae7aa35a6903df973210b016 401 PRINTS PR00359 B-class P450 signature 278 289 3.5E-56 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS15940 18640af5ae7aa35a6903df973210b016 401 PRINTS PR00359 B-class P450 signature 295 322 3.5E-56 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS16140 c6b270bc3faa3400b0214f3eea27a39e 71 Pfam PF14117 Domain of unknown function (DUF4287) 8 64 1.9E-28 T 09-03-2017 IPR025629 Protein of unknown function DUF4287 TK78_RS14125 89fa0ce632a3d34594001fd4b0fbd700 180 Gene3D G3DSA:3.10.180.10 9 130 2.6E-15 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS14125 89fa0ce632a3d34594001fd4b0fbd700 180 SUPERFAMILY SSF54593 10 133 4.56E-18 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS13665 63ef06dce66ecdb786550e711b4be14c 119 Hamap MF_01394 NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic [ndhC]. 1 119 17.824 T 09-03-2017 IPR023043 NAD(P)H-quinone oxidoreductase subunit 3, bacterial/plastid GO:0016651|GO:0055114 TK78_RS13665 63ef06dce66ecdb786550e711b4be14c 119 Pfam PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 19 118 1.6E-36 T 09-03-2017 IPR000440 NADH:ubiquinone/plastoquinone oxidoreductase, chain 3 GO:0008137|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS14995 b880210af9ec2f9cb61c70ce6b1c9bf5 68 PRINTS PR00050 Cold shock protein signature 24 33 1.2E-19 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS14995 b880210af9ec2f9cb61c70ce6b1c9bf5 68 PRINTS PR00050 Cold shock protein signature 39 57 1.2E-19 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS14995 b880210af9ec2f9cb61c70ce6b1c9bf5 68 PRINTS PR00050 Cold shock protein signature 4 19 1.2E-19 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS14995 b880210af9ec2f9cb61c70ce6b1c9bf5 68 PIRSF PIRSF002599 1 67 8.7E-26 T 09-03-2017 IPR012156 Cold shock, CspA GO:0003676 TK78_RS14995 b880210af9ec2f9cb61c70ce6b1c9bf5 68 SUPERFAMILY SSF50249 1 64 1.11E-24 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS14995 b880210af9ec2f9cb61c70ce6b1c9bf5 68 ProSitePatterns PS00352 'Cold-shock' domain signature. 15 33 - T 09-03-2017 IPR019844 Cold-shock conserved site TK78_RS14995 b880210af9ec2f9cb61c70ce6b1c9bf5 68 Pfam PF00313 'Cold-shock' DNA-binding domain 3 64 6.5E-31 T 09-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TK78_RS14995 b880210af9ec2f9cb61c70ce6b1c9bf5 68 SMART SM00357 3 66 1.4E-30 T 09-03-2017 IPR011129 Cold shock protein GO:0003676 TK78_RS14995 b880210af9ec2f9cb61c70ce6b1c9bf5 68 Gene3D G3DSA:2.40.50.140 1 65 1.4E-32 T 09-03-2017 IPR012340 Nucleic acid-binding, OB-fold TK78_RS30260 3d383539ee55050ddd7c09f3879e2247 545 ProSitePatterns PS01128 Shikimate kinase signature. 59 84 - T 09-03-2017 IPR023000 Shikimate kinase, conserved site KEGG: 00400+2.7.1.71|MetaCyc: PWY-6163 TK78_RS30260 3d383539ee55050ddd7c09f3879e2247 545 Gene3D G3DSA:3.40.50.300 3 167 4.3E-46 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS30260 3d383539ee55050ddd7c09f3879e2247 545 TIGRFAM TIGR01357 aroB: 3-dehydroquinate synthase 201 528 9.3E-107 T 09-03-2017 IPR016037 3-dehydroquinate synthase AroB GO:0003856|GO:0005737|GO:0009073 KEGG: 00400+4.2.3.4|MetaCyc: PWY-6164 TK78_RS30260 3d383539ee55050ddd7c09f3879e2247 545 Pfam PF01761 3-dehydroquinate synthase 253 509 1.2E-91 T 09-03-2017 IPR030960 3-dehydroquinate synthase domain KEGG: 00400+4.2.3.4|MetaCyc: PWY-6164 TK78_RS30260 3d383539ee55050ddd7c09f3879e2247 545 Pfam PF01202 Shikimate kinase 12 166 6.0E-39 T 09-03-2017 IPR031322 Shikimate kinase/gluconokinase KEGG: 00400+2.7.1.71|MetaCyc: PWY-6163 TK78_RS30260 3d383539ee55050ddd7c09f3879e2247 545 Gene3D G3DSA:3.40.50.1970 196 357 3.6E-53 T 09-03-2017 TK78_RS30260 3d383539ee55050ddd7c09f3879e2247 545 SUPERFAMILY SSF52540 3 166 3.18E-23 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS30260 3d383539ee55050ddd7c09f3879e2247 545 SUPERFAMILY SSF56796 198 540 3.93E-99 T 09-03-2017 TK78_RS30260 3d383539ee55050ddd7c09f3879e2247 545 PRINTS PR01100 Shikimate kinase family signature 58 66 1.3E-14 T 09-03-2017 TK78_RS30260 3d383539ee55050ddd7c09f3879e2247 545 PRINTS PR01100 Shikimate kinase family signature 96 113 1.3E-14 T 09-03-2017 TK78_RS30260 3d383539ee55050ddd7c09f3879e2247 545 PRINTS PR01100 Shikimate kinase family signature 6 21 1.3E-14 T 09-03-2017 TK78_RS30260 3d383539ee55050ddd7c09f3879e2247 545 PRINTS PR01100 Shikimate kinase family signature 30 43 1.3E-14 T 09-03-2017 TK78_RS30260 3d383539ee55050ddd7c09f3879e2247 545 PRINTS PR01100 Shikimate kinase family signature 76 85 1.3E-14 T 09-03-2017 TK78_RS30260 3d383539ee55050ddd7c09f3879e2247 545 Gene3D G3DSA:1.20.1090.10 359 539 1.1E-60 T 09-03-2017 TK78_RS30260 3d383539ee55050ddd7c09f3879e2247 545 Hamap MF_00109 Shikimate kinase [aroK]. 3 167 25.632 T 09-03-2017 IPR000623 Shikimate kinase/Threonine synthase-like 1 KEGG: 00400+2.7.1.71|MetaCyc: PWY-6163 TK78_RS30260 3d383539ee55050ddd7c09f3879e2247 545 Hamap MF_00110 3-dehydroquinate synthase [aroB]. 190 542 36.649 T 09-03-2017 IPR016037 3-dehydroquinate synthase AroB GO:0003856|GO:0005737|GO:0009073 KEGG: 00400+4.2.3.4|MetaCyc: PWY-6164 TK78_RS31225 729ea2fd24974be67274dde35697457f 170 Pfam PF04978 Protein of unknown function (DUF664) 19 166 7.5E-49 T 09-03-2017 IPR007061 Protein of unknown function DUF664 TK78_RS31225 729ea2fd24974be67274dde35697457f 170 Gene3D G3DSA:1.20.120.450 4 169 5.6E-47 T 09-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase TK78_RS31225 729ea2fd24974be67274dde35697457f 170 SUPERFAMILY SSF109854 3 165 1.98E-44 T 09-03-2017 TK78_RS21305 23a16a612b3a0576ada3aad318c8f39e 165 Pfam PF01047 MarR family 54 111 2.3E-12 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS21305 23a16a612b3a0576ada3aad318c8f39e 165 SUPERFAMILY SSF46785 11 160 4.05E-32 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS21305 23a16a612b3a0576ada3aad318c8f39e 165 SMART SM00347 43 146 4.2E-23 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS21305 23a16a612b3a0576ada3aad318c8f39e 165 Gene3D G3DSA:1.10.10.10 9 161 9.1E-36 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS21305 23a16a612b3a0576ada3aad318c8f39e 165 PRINTS PR00598 Bacterial regulatory protein MarR family signature 136 156 1.7E-8 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS21305 23a16a612b3a0576ada3aad318c8f39e 165 PRINTS PR00598 Bacterial regulatory protein MarR family signature 70 86 1.7E-8 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS21305 23a16a612b3a0576ada3aad318c8f39e 165 PRINTS PR00598 Bacterial regulatory protein MarR family signature 106 122 1.7E-8 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS21305 23a16a612b3a0576ada3aad318c8f39e 165 PRINTS PR00598 Bacterial regulatory protein MarR family signature 87 102 1.7E-8 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS22995 f1a9f160062f84011deb8fb8478f93a5 513 Gene3D G3DSA:3.40.720.10 28 264 8.2E-35 T 09-03-2017 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 TK78_RS22995 f1a9f160062f84011deb8fb8478f93a5 513 SUPERFAMILY SSF53649 36 302 5.1E-40 T 09-03-2017 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 TK78_RS22995 f1a9f160062f84011deb8fb8478f93a5 513 Pfam PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 47 120 5.2E-12 T 09-03-2017 IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase GO:0003824 TK78_RS22995 f1a9f160062f84011deb8fb8478f93a5 513 Pfam PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 179 257 2.3E-9 T 09-03-2017 IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase GO:0003824 TK78_RS05640 bdb75c1f7defa45598ab61b3226153dd 320 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 3 62 2.7E-23 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS05640 bdb75c1f7defa45598ab61b3226153dd 320 Gene3D G3DSA:1.10.10.10 1 81 7.5E-31 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05640 bdb75c1f7defa45598ab61b3226153dd 320 Gene3D G3DSA:3.40.190.10 82 178 1.1E-19 T 09-03-2017 TK78_RS05640 bdb75c1f7defa45598ab61b3226153dd 320 SUPERFAMILY SSF53850 90 287 8.28E-29 T 09-03-2017 TK78_RS05640 bdb75c1f7defa45598ab61b3226153dd 320 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 4.6E-10 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS05640 bdb75c1f7defa45598ab61b3226153dd 320 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 4.6E-10 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS05640 bdb75c1f7defa45598ab61b3226153dd 320 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 4.6E-10 T 09-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TK78_RS05640 bdb75c1f7defa45598ab61b3226153dd 320 Pfam PF03466 LysR substrate binding domain 87 287 1.3E-29 T 09-03-2017 IPR005119 LysR, substrate-binding TK78_RS05640 bdb75c1f7defa45598ab61b3226153dd 320 SUPERFAMILY SSF46785 1 84 8.18E-25 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS05640 bdb75c1f7defa45598ab61b3226153dd 320 Gene3D G3DSA:3.40.190.10 179 265 1.5E-18 T 09-03-2017 TK78_RS15030 192869219335e2cd454f6367c441170a 260 SMART SM00382 44 229 4.0E-17 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS15030 192869219335e2cd454f6367c441170a 260 Pfam PF00005 ABC transporter 35 181 3.0E-31 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS15030 192869219335e2cd454f6367c441170a 260 ProSitePatterns PS00211 ABC transporters family signature. 154 168 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS15030 192869219335e2cd454f6367c441170a 260 Gene3D G3DSA:3.40.50.300 12 232 2.5E-70 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15030 192869219335e2cd454f6367c441170a 260 SUPERFAMILY SSF52540 14 233 4.26E-68 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS12280 d5e878edad190763ee1bb65f058d6f03 222 Pfam PF02669 K+-transporting ATPase, c chain 15 218 1.8E-64 T 09-03-2017 IPR003820 Potassium-transporting ATPase C chain GO:0006813|GO:0008556|GO:0016021 TK78_RS12280 d5e878edad190763ee1bb65f058d6f03 222 PIRSF PIRSF001296 9 222 1.7E-66 T 09-03-2017 IPR003820 Potassium-transporting ATPase C chain GO:0006813|GO:0008556|GO:0016021 TK78_RS12280 d5e878edad190763ee1bb65f058d6f03 222 TIGRFAM TIGR00681 kdpC: K+-transporting ATPase, C subunit 13 218 5.5E-47 T 09-03-2017 IPR003820 Potassium-transporting ATPase C chain GO:0006813|GO:0008556|GO:0016021 TK78_RS12280 d5e878edad190763ee1bb65f058d6f03 222 Hamap MF_00276 Potassium-transporting ATPase KdpC subunit [kdpC]. 10 220 32.137 T 09-03-2017 IPR003820 Potassium-transporting ATPase C chain GO:0006813|GO:0008556|GO:0016021 TK78_RS05430 f04805e6e30e0cfee5050ff1720d3d2d 254 Pfam PF12833 Helix-turn-helix domain 160 235 1.5E-13 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS05430 f04805e6e30e0cfee5050ff1720d3d2d 254 SMART SM00342 153 235 1.2E-9 T 09-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 TK78_RS28290 56c16551a0158d2c7f543c3b54df3054 263 SUPERFAMILY SSF52096 10 255 2.28E-62 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS28290 56c16551a0158d2c7f543c3b54df3054 263 Pfam PF00378 Enoyl-CoA hydratase/isomerase 19 249 6.2E-40 T 09-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 TK78_RS28290 56c16551a0158d2c7f543c3b54df3054 263 Gene3D G3DSA:3.90.226.10 11 255 9.0E-60 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS28290 56c16551a0158d2c7f543c3b54df3054 263 ProSitePatterns PS00166 Enoyl-CoA hydratase/isomerase signature. 119 139 - T 09-03-2017 IPR018376 Enoyl-CoA hydratase/isomerase, conserved site GO:0003824|GO:0008152 TK78_RS00280 3bcd33bef1935c8aea88cddc6da5c849 100 ProSitePatterns PS00018 EF-hand calcium-binding domain. 73 85 - T 09-03-2017 IPR018247 EF-Hand 1, calcium-binding site TK78_RS18830 4cc37ced170d3260102fffd2bb5ddfc3 84 Gene3D G3DSA:3.10.20.30 5 84 1.6E-13 T 09-03-2017 IPR012675 Beta-grasp domain TK78_RS18830 4cc37ced170d3260102fffd2bb5ddfc3 84 Pfam PF02597 ThiS family 6 84 4.0E-11 T 09-03-2017 IPR003749 ThiamineS/Molybdopterin converting factor subunit 1 Reactome: R-HSA-947581 TK78_RS18830 4cc37ced170d3260102fffd2bb5ddfc3 84 SUPERFAMILY SSF54285 5 84 3.11E-14 T 09-03-2017 IPR016155 Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp TK78_RS10525 f005e5dbdf4e7e85ee870fb5bf4e37bd 383 Pfam PF01370 NAD dependent epimerase/dehydratase family 39 247 4.3E-17 T 09-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 TK78_RS10525 f005e5dbdf4e7e85ee870fb5bf4e37bd 383 SUPERFAMILY SSF51735 33 337 7.63E-33 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS10525 f005e5dbdf4e7e85ee870fb5bf4e37bd 383 Gene3D G3DSA:3.40.50.720 26 247 3.6E-28 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS12275 05b2ff93e542d9370f7f24d0e9a030bd 255 SUPERFAMILY SSF88659 121 180 7.1E-10 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12275 05b2ff93e542d9370f7f24d0e9a030bd 255 Pfam PF08281 Sigma-70, region 4 127 176 7.7E-11 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12275 05b2ff93e542d9370f7f24d0e9a030bd 255 Gene3D G3DSA:1.10.10.10 124 181 8.5E-13 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS12275 05b2ff93e542d9370f7f24d0e9a030bd 255 Pfam PF04542 Sigma-70 region 2 27 94 1.5E-15 T 09-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12275 05b2ff93e542d9370f7f24d0e9a030bd 255 SUPERFAMILY SSF88946 4 106 1.33E-24 T 09-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS12275 05b2ff93e542d9370f7f24d0e9a030bd 255 Gene3D G3DSA:1.10.1740.10 7 112 3.6E-25 T 09-03-2017 TK78_RS12275 05b2ff93e542d9370f7f24d0e9a030bd 255 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 21 179 8.4E-20 T 09-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS21825 59dd3c975930b1da75f7cb9afde1bf99 395 Gene3D G3DSA:3.40.50.1110 176 376 1.2E-8 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS21825 59dd3c975930b1da75f7cb9afde1bf99 395 SUPERFAMILY SSF52266 171 377 3.33E-22 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS21825 59dd3c975930b1da75f7cb9afde1bf99 395 Pfam PF14606 GDSL-like Lipase/Acylhydrolase family 179 278 2.7E-13 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS25430 23d5ba1873d162bcccd4e347c58a4178 202 PIRSF PIRSF006324 1 202 1.6E-46 T 09-03-2017 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 TK78_RS25430 23d5ba1873d162bcccd4e347c58a4178 202 Pfam PF01810 LysE type translocator 14 200 4.3E-27 T 09-03-2017 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 TK78_RS25355 887b2d3048ee64ba45000d024455960f 207 SUPERFAMILY SSF46689 4 84 5.64E-14 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS25355 887b2d3048ee64ba45000d024455960f 207 Gene3D G3DSA:1.10.10.60 2 65 6.1E-19 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS25355 887b2d3048ee64ba45000d024455960f 207 Gene3D G3DSA:1.10.357.10 70 199 1.5E-41 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS25355 887b2d3048ee64ba45000d024455960f 207 SUPERFAMILY SSF48498 81 196 2.94E-29 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS25355 887b2d3048ee64ba45000d024455960f 207 Pfam PF00440 Bacterial regulatory proteins, tetR family 16 61 4.5E-10 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS28690 fd91cde07119410bc293ee7a28655690 341 SUPERFAMILY SSF101478 13 228 1.44E-57 T 09-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 TK78_RS28690 fd91cde07119410bc293ee7a28655690 341 SUPERFAMILY SSF101478 261 336 1.44E-57 T 09-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 TK78_RS28690 fd91cde07119410bc293ee7a28655690 341 Pfam PF03747 ADP-ribosylglycohydrolase 15 321 4.7E-59 T 09-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 TK78_RS00950 d72e03f95a74159c11618332451ea2ee 162 Pfam PF00583 Acetyltransferase (GNAT) family 56 135 2.3E-12 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS00950 d72e03f95a74159c11618332451ea2ee 162 SUPERFAMILY SSF55729 1 162 1.2E-27 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS00950 d72e03f95a74159c11618332451ea2ee 162 Gene3D G3DSA:3.40.630.30 1 162 1.1E-30 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS30480 c5dac7fc947e668f99f1a08e1d04161b 90 TIGRFAM TIGR03188 histidine_hisI: phosphoribosyl-ATP diphosphatase 7 90 4.3E-24 T 09-03-2017 IPR008179 Phosphoribosyl-ATP pyrophosphohydrolase GO:0000105|GO:0004636 KEGG: 00340+3.6.1.31 TK78_RS30480 c5dac7fc947e668f99f1a08e1d04161b 90 Pfam PF01503 Phosphoribosyl-ATP pyrophosphohydrolase 17 89 2.4E-10 T 09-03-2017 IPR021130 Phosphoribosyl-ATP pyrophosphohydrolase-like KEGG: 00340+3.6.1.31 TK78_RS30480 c5dac7fc947e668f99f1a08e1d04161b 90 Hamap MF_01020 Phosphoribosyl-ATP pyrophosphatase [hisE]. 3 90 19.579 T 09-03-2017 IPR008179 Phosphoribosyl-ATP pyrophosphohydrolase GO:0000105|GO:0004636 KEGG: 00340+3.6.1.31 TK78_RS30480 c5dac7fc947e668f99f1a08e1d04161b 90 SUPERFAMILY SSF101386 5 90 7.29E-21 T 09-03-2017 TK78_RS06285 68cd3d1b1c873127d1c30ed2c1289b30 337 Gene3D G3DSA:3.40.50.720 3 188 2.8E-41 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS06285 68cd3d1b1c873127d1c30ed2c1289b30 337 SUPERFAMILY SSF51735 3 321 9.3E-76 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS06285 68cd3d1b1c873127d1c30ed2c1289b30 337 Pfam PF16363 GDP-mannose 4,6 dehydratase 6 316 7.7E-136 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS06285 68cd3d1b1c873127d1c30ed2c1289b30 337 TIGRFAM TIGR01472 gmd: GDP-mannose 4,6-dehydratase 3 322 4.2E-152 T 09-03-2017 IPR006368 GDP-mannose 4,6-dehydratase GO:0008446|GO:0019673 KEGG: 00051+4.2.1.47|KEGG: 00520+4.2.1.47|MetaCyc: PWY-5738|MetaCyc: PWY-5739|MetaCyc: PWY-5740|MetaCyc: PWY-66|MetaCyc: PWY-7573|Reactome: R-HSA-6787639 TK78_RS06285 68cd3d1b1c873127d1c30ed2c1289b30 337 Gene3D G3DSA:3.90.25.10 190 327 3.2E-46 T 09-03-2017 TK78_RS06285 68cd3d1b1c873127d1c30ed2c1289b30 337 Hamap MF_00955 GDP-mannose 4,6-dehydratase [gmd]. 3 326 55.153 T 09-03-2017 IPR006368 GDP-mannose 4,6-dehydratase GO:0008446|GO:0019673 KEGG: 00051+4.2.1.47|KEGG: 00520+4.2.1.47|MetaCyc: PWY-5738|MetaCyc: PWY-5739|MetaCyc: PWY-5740|MetaCyc: PWY-66|MetaCyc: PWY-7573|Reactome: R-HSA-6787639 TK78_RS04685 1d456227b3338f1dc8877fa84d30afae 280 Pfam PF00795 Carbon-nitrogen hydrolase 6 260 9.8E-67 T 09-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 TK78_RS04685 1d456227b3338f1dc8877fa84d30afae 280 SUPERFAMILY SSF56317 4 278 3.14E-80 T 09-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 TK78_RS04685 1d456227b3338f1dc8877fa84d30afae 280 Gene3D G3DSA:3.60.110.10 4 279 4.7E-88 T 09-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 TK78_RS03175 abdbaa90695c8c791ae192e0a06f9bb8 294 Pfam PF00535 Glycosyl transferase family 2 10 153 1.1E-9 T 09-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 TK78_RS03175 abdbaa90695c8c791ae192e0a06f9bb8 294 SUPERFAMILY SSF53448 9 223 8.04E-35 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS03175 abdbaa90695c8c791ae192e0a06f9bb8 294 Gene3D G3DSA:3.90.550.10 10 230 1.3E-24 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS12550 b47c4b48d6d6709257083004d95008e4 141 Pfam PF05423 Mycobacterium membrane protein 33 130 1.5E-4 T 09-03-2017 IPR008693 Transport accessory protein MmpS TK78_RS06025 ac68b8d29fee151a4ecc2e7eb789332b 481 Pfam PF01547 Bacterial extracellular solute-binding protein 85 381 2.0E-19 T 09-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 TK78_RS06025 ac68b8d29fee151a4ecc2e7eb789332b 481 TIGRFAM TIGR03851 chitin_NgcE: carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein 30 478 4.4E-198 T 09-03-2017 IPR022386 Carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding TK78_RS06025 ac68b8d29fee151a4ecc2e7eb789332b 481 Gene3D G3DSA:3.40.190.10 190 388 6.4E-30 T 09-03-2017 TK78_RS06025 ac68b8d29fee151a4ecc2e7eb789332b 481 SUPERFAMILY SSF53850 36 479 1.47E-53 T 09-03-2017 TK78_RS02855 e109793406b885903420f6f73421e5cf 95 Pfam PF11239 Protein of unknown function (DUF3040) 6 76 9.1E-13 T 09-03-2017 IPR021401 Protein of unknown function DUF3040 TK78_RS04555 a6332a140c94e43b9a41f43d2739ebea 486 Pfam PF07690 Major Facilitator Superfamily 20 412 4.5E-49 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS04555 a6332a140c94e43b9a41f43d2739ebea 486 SUPERFAMILY SSF103473 7 197 3.4E-59 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS04555 a6332a140c94e43b9a41f43d2739ebea 486 SUPERFAMILY SSF103473 251 457 3.4E-59 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS04555 a6332a140c94e43b9a41f43d2739ebea 486 Gene3D G3DSA:1.20.1250.20 267 457 5.0E-13 T 09-03-2017 TK78_RS04555 a6332a140c94e43b9a41f43d2739ebea 486 Gene3D G3DSA:1.20.1250.20 15 198 8.7E-29 T 09-03-2017 TK78_RS27980 bf8713ea199f1858d8e7dd1b96d1a0cc 473 SUPERFAMILY SSF101960 40 470 5.23E-139 T 09-03-2017 TK78_RS27980 bf8713ea199f1858d8e7dd1b96d1a0cc 473 TIGRFAM TIGR01980 sufB: FeS assembly protein SufB 18 464 1.5E-219 T 09-03-2017 IPR010231 SUF system FeS cluster assembly, SufB GO:0016226 TK78_RS27980 bf8713ea199f1858d8e7dd1b96d1a0cc 473 Pfam PF01458 Uncharacterized protein family (UPF0051) 219 444 2.4E-73 T 09-03-2017 IPR000825 SUF system FeS cluster assembly, SufBD GO:0016226 TK78_RS15000 1b220bcdc88f2373654d5d6850be0d38 92 SUPERFAMILY SSF54285 1 91 1.25E-23 T 09-03-2017 IPR016155 Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp TK78_RS15000 1b220bcdc88f2373654d5d6850be0d38 92 Pfam PF02597 ThiS family 5 91 2.4E-17 T 09-03-2017 IPR003749 ThiamineS/Molybdopterin converting factor subunit 1 Reactome: R-HSA-947581 TK78_RS15000 1b220bcdc88f2373654d5d6850be0d38 92 Gene3D G3DSA:3.10.20.30 3 89 5.2E-29 T 09-03-2017 IPR012675 Beta-grasp domain TK78_RS13850 8f1ae8a528464fac88ba8ecd11c47878 230 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 46 128 5.4E-18 T 09-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS13850 8f1ae8a528464fac88ba8ecd11c47878 230 PIRSF PIRSF000190 7 230 9.4E-54 T 09-03-2017 IPR000659 Pyridoxamine 5'-phosphate oxidase GO:0004733|GO:0008615|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS13850 8f1ae8a528464fac88ba8ecd11c47878 230 Pfam PF10590 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region 183 230 1.4E-11 T 09-03-2017 IPR019576 Pyridoxine 5'-phosphate oxidase, dimerisation, C-terminal GO:0016638|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS13850 8f1ae8a528464fac88ba8ecd11c47878 230 SUPERFAMILY SSF50475 22 230 2.95E-45 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS13850 8f1ae8a528464fac88ba8ecd11c47878 230 Gene3D G3DSA:2.30.110.10 28 230 4.6E-55 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS03605 7944b2376d06dca286d0a0b3472ed30d 526 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 361 370 - T 09-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 TK78_RS03605 7944b2376d06dca286d0a0b3472ed30d 526 SUPERFAMILY SSF48264 33 421 2.36E-66 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS03605 7944b2376d06dca286d0a0b3472ed30d 526 Gene3D G3DSA:1.10.630.10 31 423 9.4E-92 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS03605 7944b2376d06dca286d0a0b3472ed30d 526 PRINTS PR00359 B-class P450 signature 165 181 4.7E-24 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS03605 7944b2376d06dca286d0a0b3472ed30d 526 PRINTS PR00359 B-class P450 signature 119 130 4.7E-24 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS03605 7944b2376d06dca286d0a0b3472ed30d 526 PRINTS PR00359 B-class P450 signature 182 197 4.7E-24 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS03605 7944b2376d06dca286d0a0b3472ed30d 526 PRINTS PR00359 B-class P450 signature 312 339 4.7E-24 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS03605 7944b2376d06dca286d0a0b3472ed30d 526 PRINTS PR00359 B-class P450 signature 359 368 4.7E-24 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS03605 7944b2376d06dca286d0a0b3472ed30d 526 PRINTS PR00359 B-class P450 signature 216 238 4.7E-24 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS09865 467dcbcbb13492a5960eefb3946c916d 790 SUPERFAMILY SSF48371 569 712 7.12E-18 T 09-03-2017 IPR016024 Armadillo-type fold GO:0005488 TK78_RS09865 467dcbcbb13492a5960eefb3946c916d 790 SUPERFAMILY SSF48371 22 236 7.12E-18 T 09-03-2017 IPR016024 Armadillo-type fold GO:0005488 TK78_RS09865 467dcbcbb13492a5960eefb3946c916d 790 SUPERFAMILY SSF48371 397 464 7.12E-18 T 09-03-2017 IPR016024 Armadillo-type fold GO:0005488 TK78_RS09865 467dcbcbb13492a5960eefb3946c916d 790 Gene3D G3DSA:1.25.10.10 492 532 1.1E-17 T 09-03-2017 IPR011989 Armadillo-like helical TK78_RS09865 467dcbcbb13492a5960eefb3946c916d 790 Gene3D G3DSA:1.25.10.10 18 237 1.1E-8 T 09-03-2017 IPR011989 Armadillo-like helical TK78_RS09865 467dcbcbb13492a5960eefb3946c916d 790 Gene3D G3DSA:1.25.10.10 572 753 1.1E-17 T 09-03-2017 IPR011989 Armadillo-like helical TK78_RS09865 467dcbcbb13492a5960eefb3946c916d 790 SMART SM00567 E-Z type HEAT repeats 493 515 24.0 T 09-03-2017 IPR004155 PBS lyase HEAT-like repeat Reactome: R-HSA-204626 TK78_RS09865 467dcbcbb13492a5960eefb3946c916d 790 SMART SM00567 E-Z type HEAT repeats 654 685 40.0 T 09-03-2017 IPR004155 PBS lyase HEAT-like repeat Reactome: R-HSA-204626 TK78_RS09865 467dcbcbb13492a5960eefb3946c916d 790 SMART SM00567 E-Z type HEAT repeats 621 652 590.0 T 09-03-2017 IPR004155 PBS lyase HEAT-like repeat Reactome: R-HSA-204626 TK78_RS09865 467dcbcbb13492a5960eefb3946c916d 790 SMART SM00567 E-Z type HEAT repeats 588 619 3.1 T 09-03-2017 IPR004155 PBS lyase HEAT-like repeat Reactome: R-HSA-204626 TK78_RS25230 57f28adff3e9a39647829bf28d062076 307 SUPERFAMILY SSF53800 64 291 6.87E-36 T 09-03-2017 TK78_RS25230 57f28adff3e9a39647829bf28d062076 307 Gene3D G3DSA:3.40.50.1400 186 293 3.6E-19 T 09-03-2017 TK78_RS25230 57f28adff3e9a39647829bf28d062076 307 Gene3D G3DSA:3.40.50.1400 65 177 7.2E-26 T 09-03-2017 TK78_RS25230 57f28adff3e9a39647829bf28d062076 307 Pfam PF01903 CbiX 71 167 2.3E-18 T 09-03-2017 IPR002762 Cobalamin (vitamin B12) biosynthesis CbiX GO:0009236|GO:0016852 KEGG: 00860+4.99.1.3|MetaCyc: PWY-7377 TK78_RS25230 57f28adff3e9a39647829bf28d062076 307 Pfam PF01903 CbiX 194 284 2.3E-9 T 09-03-2017 IPR002762 Cobalamin (vitamin B12) biosynthesis CbiX GO:0009236|GO:0016852 KEGG: 00860+4.99.1.3|MetaCyc: PWY-7377 TK78_RS17035 f9d4894788ca3fd445a2ab34f168f352 286 SUPERFAMILY SSF55920 13 169 3.66E-25 T 09-03-2017 IPR000994 Peptidase M24, structural domain TK78_RS17035 f9d4894788ca3fd445a2ab34f168f352 286 SUPERFAMILY SSF55920 209 259 3.66E-25 T 09-03-2017 IPR000994 Peptidase M24, structural domain TK78_RS17035 f9d4894788ca3fd445a2ab34f168f352 286 Pfam PF00557 Metallopeptidase family M24 18 258 2.1E-28 T 09-03-2017 IPR000994 Peptidase M24, structural domain TK78_RS17035 f9d4894788ca3fd445a2ab34f168f352 286 Gene3D G3DSA:3.90.230.10 15 259 2.0E-25 T 09-03-2017 IPR000994 Peptidase M24, structural domain TK78_RS12160 8dd6eeabaeb9c0be2fdf887dc26ff0fa 198 Pfam PF05685 Putative restriction endonuclease 26 191 2.3E-16 T 09-03-2017 IPR008538 Domain of unknown function DUF820 TK78_RS12160 8dd6eeabaeb9c0be2fdf887dc26ff0fa 198 SUPERFAMILY SSF52980 30 152 5.04E-13 T 09-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 TK78_RS12160 8dd6eeabaeb9c0be2fdf887dc26ff0fa 198 Gene3D G3DSA:3.90.1570.10 30 150 1.9E-14 T 09-03-2017 IPR012296 Nuclease, putative, TT1808 TK78_RS20000 ae612862339471a56e0c8c7b6e84a725 96 SUPERFAMILY SSF52833 6 90 2.73E-19 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS20000 ae612862339471a56e0c8c7b6e84a725 96 Pfam PF05768 Glutaredoxin-like domain (DUF836) 17 89 9.3E-18 T 09-03-2017 IPR008554 Glutaredoxin-like TK78_RS20000 ae612862339471a56e0c8c7b6e84a725 96 Gene3D G3DSA:3.40.30.10 17 91 1.2E-26 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS30910 1eaa32d99a9b0a58297cd638977965ba 143 Pfam PF10604 Polyketide cyclase / dehydrase and lipid transport 1 137 4.0E-20 T 09-03-2017 IPR019587 Polyketide cyclase/dehydrase TK78_RS30910 1eaa32d99a9b0a58297cd638977965ba 143 SUPERFAMILY SSF55961 1 139 4.99E-21 T 09-03-2017 TK78_RS30910 1eaa32d99a9b0a58297cd638977965ba 143 Gene3D G3DSA:3.30.530.20 1 142 3.8E-16 T 09-03-2017 IPR023393 START-like domain TK78_RS05045 ddc6fb32f6c33cbc4b1bc011e4f76095 279 PIRSF PIRSF006241 4 278 1.0E-82 T 09-03-2017 IPR026040 Hydroxypyruvate isomerase-like KEGG: 00630+5.3.1.22 TK78_RS05045 ddc6fb32f6c33cbc4b1bc011e4f76095 279 Gene3D G3DSA:3.20.20.150 7 272 4.9E-71 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS05045 ddc6fb32f6c33cbc4b1bc011e4f76095 279 Pfam PF01261 Xylose isomerase-like TIM barrel 26 229 1.2E-28 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS05045 ddc6fb32f6c33cbc4b1bc011e4f76095 279 SUPERFAMILY SSF51658 10 270 1.52E-57 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS23645 81b9d049559326335b2ffe19cb34fd44 283 SUPERFAMILY SSF55729 121 277 6.56E-17 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS23645 81b9d049559326335b2ffe19cb34fd44 283 Pfam PF00583 Acetyltransferase (GNAT) family 210 269 4.6E-7 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS23645 81b9d049559326335b2ffe19cb34fd44 283 Gene3D G3DSA:3.40.630.30 151 279 2.0E-15 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS29995 44c539562f6df963e8393fe23cc12b62 172 Gene3D G3DSA:3.40.30.10 5 164 2.0E-36 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS29995 44c539562f6df963e8393fe23cc12b62 172 SUPERFAMILY SSF52833 6 160 2.67E-32 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS29995 44c539562f6df963e8393fe23cc12b62 172 Pfam PF13462 Thioredoxin 6 160 3.9E-23 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS02425 658b07401e67ac8b50597b689167bea9 366 SUPERFAMILY SSF47413 11 67 3.85E-15 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS02425 658b07401e67ac8b50597b689167bea9 366 SMART SM00354 10 80 1.0E-19 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS02425 658b07401e67ac8b50597b689167bea9 366 Gene3D G3DSA:1.10.260.40 10 60 3.5E-20 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS02425 658b07401e67ac8b50597b689167bea9 366 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 12 22 1.3E-6 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS02425 658b07401e67ac8b50597b689167bea9 366 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 22 32 1.3E-6 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS02425 658b07401e67ac8b50597b689167bea9 366 Gene3D G3DSA:3.40.50.2300 109 212 1.9E-24 T 09-03-2017 TK78_RS02425 658b07401e67ac8b50597b689167bea9 366 Gene3D G3DSA:3.40.50.2300 61 77 1.9E-24 T 09-03-2017 TK78_RS02425 658b07401e67ac8b50597b689167bea9 366 SUPERFAMILY SSF53822 109 363 6.89E-63 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS02425 658b07401e67ac8b50597b689167bea9 366 Gene3D G3DSA:3.40.50.2300 213 347 2.8E-51 T 09-03-2017 TK78_RS02425 658b07401e67ac8b50597b689167bea9 366 Pfam PF00356 Bacterial regulatory proteins, lacI family 12 57 7.3E-15 T 09-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 TK78_RS02425 658b07401e67ac8b50597b689167bea9 366 Pfam PF13377 Periplasmic binding protein-like domain 207 365 2.2E-38 T 09-03-2017 TK78_RS02425 658b07401e67ac8b50597b689167bea9 366 ProSitePatterns PS00356 LacI-type HTH domain signature. 13 31 - T 09-03-2017 TK78_RS00245 4024e4453a07d1b5b2cd6826f1250346 218 Gene3D G3DSA:3.40.50.720 1 190 7.2E-44 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS00245 4024e4453a07d1b5b2cd6826f1250346 218 Pfam PF03807 NADP oxidoreductase coenzyme F420-dependent 4 91 4.8E-15 T 09-03-2017 IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal TK78_RS00245 4024e4453a07d1b5b2cd6826f1250346 218 SUPERFAMILY SSF51735 4 200 4.22E-29 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS10205 ce07c31d5f29ca6e4860849d184ae445 347 SUPERFAMILY SSF48576 48 346 4.17E-72 T 09-03-2017 IPR008949 Isoprenoid synthase domain TK78_RS10205 ce07c31d5f29ca6e4860849d184ae445 347 Pfam PF00348 Polyprenyl synthetase 60 295 6.7E-56 T 09-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 TK78_RS10205 ce07c31d5f29ca6e4860849d184ae445 347 ProSitePatterns PS00723 Polyprenyl synthases signature 1. 99 113 - T 09-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 TK78_RS10205 ce07c31d5f29ca6e4860849d184ae445 347 Gene3D G3DSA:1.10.600.10 15 346 2.7E-82 T 09-03-2017 IPR008949 Isoprenoid synthase domain TK78_RS17030 809868ef4d006c50bcdfbe350aad8155 334 SUPERFAMILY SSF52540 2 202 8.54E-54 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17030 809868ef4d006c50bcdfbe350aad8155 334 SMART SM00382 17 201 2.3E-11 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS17030 809868ef4d006c50bcdfbe350aad8155 334 Gene3D G3DSA:3.40.50.300 2 216 1.8E-58 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17030 809868ef4d006c50bcdfbe350aad8155 334 Pfam PF00005 ABC transporter 10 152 9.4E-27 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS33360 2aef644aead87a7e26290427dcc1205f 392 SUPERFAMILY SSF53474 26 375 4.01E-94 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS33360 2aef644aead87a7e26290427dcc1205f 392 PIRSF PIRSF000443 17 380 1.0E-121 T 09-03-2017 IPR008220 Homoserine acetyltransferase GO:0004414|GO:0005737|GO:0009086 KEGG: 00270+2.3.1.31|MetaCyc: PWY-5344 TK78_RS33360 2aef644aead87a7e26290427dcc1205f 392 Hamap MF_00296 Homoserine O-acetyltransferase [metX]. 12 376 45.278 T 09-03-2017 IPR008220 Homoserine acetyltransferase GO:0004414|GO:0005737|GO:0009086 KEGG: 00270+2.3.1.31|MetaCyc: PWY-5344 TK78_RS33360 2aef644aead87a7e26290427dcc1205f 392 Pfam PF00561 alpha/beta hydrolase fold 56 361 9.2E-30 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS33360 2aef644aead87a7e26290427dcc1205f 392 TIGRFAM TIGR01392 homoserO_Ac_trn: homoserine O-acetyltransferase 27 374 5.6E-131 T 09-03-2017 IPR008220 Homoserine acetyltransferase GO:0004414|GO:0005737|GO:0009086 KEGG: 00270+2.3.1.31|MetaCyc: PWY-5344 TK78_RS33360 2aef644aead87a7e26290427dcc1205f 392 Gene3D G3DSA:3.40.50.1820 36 208 3.0E-39 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS33360 2aef644aead87a7e26290427dcc1205f 392 Gene3D G3DSA:3.40.50.1820 241 375 3.0E-39 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS06940 fb567f53d60bc29d2240526ed2070a55 414 SUPERFAMILY SSF103473 17 392 4.58E-33 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS06940 fb567f53d60bc29d2240526ed2070a55 414 Pfam PF07690 Major Facilitator Superfamily 21 299 4.8E-13 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS06940 fb567f53d60bc29d2240526ed2070a55 414 Gene3D G3DSA:1.20.1250.20 17 190 2.3E-9 T 09-03-2017 TK78_RS06940 fb567f53d60bc29d2240526ed2070a55 414 Gene3D G3DSA:1.20.1250.20 210 389 1.1E-15 T 09-03-2017 TK78_RS24555 31fccf7614de72450538372baeb3f5c3 922 Pfam PF04464 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase 559 913 5.7E-105 T 09-03-2017 IPR007554 CDP-glycerol glycerophosphotransferase GO:0016020|GO:0047355 TK78_RS24555 31fccf7614de72450538372baeb3f5c3 922 SUPERFAMILY SSF53756 681 916 5.89E-15 T 09-03-2017 TK78_RS33910 42c7342f364df15496125eba52c0bfc2 265 SUPERFAMILY SSF52799 8 261 1.98E-44 T 09-03-2017 IPR029021 Protein-tyrosine phosphatase-like TK78_RS33910 42c7342f364df15496125eba52c0bfc2 265 ProSitePatterns PS00383 Tyrosine specific protein phosphatases active site. 155 165 - T 09-03-2017 IPR016130 Protein-tyrosine phosphatase, active site GO:0004725|GO:0016311|GO:0016791 TK78_RS33910 42c7342f364df15496125eba52c0bfc2 265 Gene3D G3DSA:3.90.190.10 32 100 3.7E-18 T 09-03-2017 IPR029021 Protein-tyrosine phosphatase-like TK78_RS33910 42c7342f364df15496125eba52c0bfc2 265 Gene3D G3DSA:3.90.190.10 142 197 3.7E-18 T 09-03-2017 IPR029021 Protein-tyrosine phosphatase-like TK78_RS33910 42c7342f364df15496125eba52c0bfc2 265 Pfam PF13350 Tyrosine phosphatase family 8 262 4.3E-58 T 09-03-2017 IPR026893 Tyrosine/serine-protein phosphatase IphP-type TK78_RS23960 90dbb1757e12339eda62fe92b3129123 527 Gene3D G3DSA:3.30.565.10 267 386 9.6E-5 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS23960 90dbb1757e12339eda62fe92b3129123 527 Pfam PF07730 Histidine kinase 159 223 6.4E-11 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS23960 90dbb1757e12339eda62fe92b3129123 527 SUPERFAMILY SSF55874 246 383 1.31E-7 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS33140 d9c80aa6e2336f4864e98182e9bbbf23 570 Gene3D G3DSA:3.40.50.300 22 248 4.6E-62 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33140 d9c80aa6e2336f4864e98182e9bbbf23 570 Pfam PF00005 ABC transporter 297 451 7.4E-24 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS33140 d9c80aa6e2336f4864e98182e9bbbf23 570 Pfam PF00005 ABC transporter 40 190 8.0E-31 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS33140 d9c80aa6e2336f4864e98182e9bbbf23 570 SMART SM00382 49 247 1.2E-8 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS33140 d9c80aa6e2336f4864e98182e9bbbf23 570 SMART SM00382 306 500 0.0014 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS33140 d9c80aa6e2336f4864e98182e9bbbf23 570 SUPERFAMILY SSF52540 22 247 1.95E-60 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33140 d9c80aa6e2336f4864e98182e9bbbf23 570 SUPERFAMILY SSF52540 292 509 6.03E-50 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS33140 d9c80aa6e2336f4864e98182e9bbbf23 570 ProSitePatterns PS00211 ABC transporters family signature. 424 438 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS33140 d9c80aa6e2336f4864e98182e9bbbf23 570 Gene3D G3DSA:3.40.50.300 292 512 9.4E-54 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS02340 0523b82db57696e38f345cfd57968420 485 Pfam PF06762 Lipase maturation factor 121 268 5.9E-58 T 09-03-2017 IPR009613 Lipase maturation factor Reactome: R-HSA-192456 TK78_RS02340 0523b82db57696e38f345cfd57968420 485 Pfam PF06762 Lipase maturation factor 288 467 6.2E-61 T 09-03-2017 IPR009613 Lipase maturation factor Reactome: R-HSA-192456 TK78_RS11505 bb0edd1eca54e7e2a03b91882025fb18 461 Pfam PF01594 Domain of unknown function DUF20 86 410 9.1E-61 T 09-03-2017 IPR002549 Transmembrane protein TqsA-like TK78_RS14370 0d639df9848aa41e05fa78405b6aa849 246 Gene3D G3DSA:3.40.50.1110 7 224 5.0E-22 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS14370 0d639df9848aa41e05fa78405b6aa849 246 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 12 210 2.8E-15 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS14370 0d639df9848aa41e05fa78405b6aa849 246 SUPERFAMILY SSF52266 5 32 6.26E-22 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS14370 0d639df9848aa41e05fa78405b6aa849 246 SUPERFAMILY SSF52266 77 224 6.26E-22 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS14865 babd2c3bdf981429b464e9ba214ee95a 944 Pfam PF03639 Glycosyl hydrolase family 81 71 683 6.2E-74 T 09-03-2017 IPR005200 Endo-1,3(4)-beta-glucanase GO:0052861 TK78_RS34175 10848a280d7193c4f8eecae33c84d81d 378 Gene3D G3DSA:3.90.1200.10 182 308 2.7E-12 T 09-03-2017 TK78_RS34175 10848a280d7193c4f8eecae33c84d81d 378 Pfam PF01636 Phosphotransferase enzyme family 95 305 7.5E-17 T 09-03-2017 IPR002575 Aminoglycoside phosphotransferase TK78_RS34175 10848a280d7193c4f8eecae33c84d81d 378 SUPERFAMILY SSF56112 89 315 9.6E-27 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS00500 191bf21740a6efba829c7e024d2f48c2 64 Pfam PF14310 Fibronectin type III-like domain 12 64 8.3E-14 T 09-03-2017 IPR026891 Fibronectin type III-like domain TK78_RS00500 191bf21740a6efba829c7e024d2f48c2 64 SMART SM01217 3 64 2.0E-8 T 09-03-2017 IPR026891 Fibronectin type III-like domain TK78_RS02010 148b6737ee4f606d596471a204bdbbd8 275 Pfam PF00805 Pentapeptide repeats (8 copies) 189 226 5.6E-11 T 09-03-2017 IPR001646 Pentapeptide repeat TK78_RS02010 148b6737ee4f606d596471a204bdbbd8 275 SUPERFAMILY SSF141571 172 269 4.22E-22 T 09-03-2017 TK78_RS02010 148b6737ee4f606d596471a204bdbbd8 275 SUPERFAMILY SSF141571 60 93 4.22E-22 T 09-03-2017 TK78_RS14415 8c8ca8a6d4ebb2a3964ab60b7cf492e0 300 Pfam PF02517 CAAX protease self-immunity 157 247 9.8E-15 T 09-03-2017 IPR003675 CAAX amino terminal protease GO:0016020 TK78_RS13975 aa8916b004f5a228e58cdb3252649e48 308 Gene3D G3DSA:3.50.30.50 89 307 7.9E-30 T 09-03-2017 TK78_RS13975 aa8916b004f5a228e58cdb3252649e48 308 Pfam PF04199 Putative cyclase 86 239 5.5E-22 T 09-03-2017 IPR007325 Kynurenine formamidase GO:0004061|GO:0019441 KEGG: 00380+3.5.1.9|KEGG: 00630+3.5.1.9|MetaCyc: PWY-5651|MetaCyc: PWY-6309|MetaCyc: PWY-7717|MetaCyc: PWY-7733|MetaCyc: PWY-7734 TK78_RS13975 aa8916b004f5a228e58cdb3252649e48 308 SUPERFAMILY SSF102198 91 307 3.92E-23 T 09-03-2017 TK78_RS30770 3e5067d2591268ab92603e88d6419846 275 Pfam PF05949 Bacterial protein of unknown function (DUF881) 138 270 3.8E-38 T 09-03-2017 IPR010273 Protein of unknown function DUF881 TK78_RS26860 6197b877bc699b0dff8f49ad02aac48f 268 Pfam PF12850 Calcineurin-like phosphoesterase superfamily domain 18 257 4.2E-8 T 09-03-2017 IPR024654 Calcineurin-like phosphoesterase domain, lpxH type Reactome: R-HSA-3238698 TK78_RS26860 6197b877bc699b0dff8f49ad02aac48f 268 Gene3D G3DSA:3.60.21.10 8 268 2.3E-21 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS26860 6197b877bc699b0dff8f49ad02aac48f 268 SUPERFAMILY SSF56300 16 61 2.31E-34 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS26860 6197b877bc699b0dff8f49ad02aac48f 268 SUPERFAMILY SSF56300 98 259 2.31E-34 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS12485 f655859c8f944b8fdd915874d8c0b88a 514 Pfam PF09852 Predicted membrane protein (DUF2079) 72 461 7.7E-60 T 09-03-2017 IPR018650 Sulfolobus virus STSV1, Orf64 TK78_RS25030 624ad6b24d3497fac0ab305da6e83edc 86 SUPERFAMILY SSF69318 20 72 6.54E-6 T 09-03-2017 TK78_RS27505 9d638cb45ceba65e87877c3ee26c57af 251 Gene3D G3DSA:1.25.40.20 122 179 1.8E-10 T 09-03-2017 IPR020683 Ankyrin repeat-containing domain TK78_RS27505 9d638cb45ceba65e87877c3ee26c57af 251 SUPERFAMILY SSF48403 17 172 1.66E-31 T 09-03-2017 IPR020683 Ankyrin repeat-containing domain TK78_RS27505 9d638cb45ceba65e87877c3ee26c57af 251 Gene3D G3DSA:1.25.40.20 17 121 3.4E-25 T 09-03-2017 IPR020683 Ankyrin repeat-containing domain TK78_RS27505 9d638cb45ceba65e87877c3ee26c57af 251 Pfam PF12796 Ankyrin repeats (3 copies) 50 134 1.9E-11 T 09-03-2017 IPR020683 Ankyrin repeat-containing domain TK78_RS27505 9d638cb45ceba65e87877c3ee26c57af 251 SMART SM00248 107 136 0.7 T 09-03-2017 IPR002110 Ankyrin repeat GO:0005515 TK78_RS27505 9d638cb45ceba65e87877c3ee26c57af 251 SMART SM00248 74 103 0.06 T 09-03-2017 IPR002110 Ankyrin repeat GO:0005515 TK78_RS27505 9d638cb45ceba65e87877c3ee26c57af 251 SMART SM00248 39 68 0.0025 T 09-03-2017 IPR002110 Ankyrin repeat GO:0005515 TK78_RS27505 9d638cb45ceba65e87877c3ee26c57af 251 SMART SM00248 140 169 3200.0 T 09-03-2017 IPR002110 Ankyrin repeat GO:0005515 TK78_RS21985 e42e5d4b2f2eac70c5d8cc2a37b3a67f 142 Pfam PF06262 Zinicin-like metallopeptidase 79 137 1.3E-7 T 09-03-2017 IPR010428 Zinicin-like metallopeptidase TK78_RS21985 e42e5d4b2f2eac70c5d8cc2a37b3a67f 142 SUPERFAMILY SSF55486 37 139 2.64E-22 T 09-03-2017 TK78_RS12570 7f7de398db19290cb85c3690e221c27a 310 SUPERFAMILY SSF53474 96 235 2.1E-28 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS12570 7f7de398db19290cb85c3690e221c27a 310 Gene3D G3DSA:3.40.50.1820 76 298 6.3E-38 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS12570 7f7de398db19290cb85c3690e221c27a 310 Pfam PF00561 alpha/beta hydrolase fold 100 199 1.2E-8 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS16350 3ea0a0d185996a8e98e766ecd4e0ca7c 131 SUPERFAMILY SSF46955 3 52 5.49E-9 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS16350 3ea0a0d185996a8e98e766ecd4e0ca7c 131 Pfam PF00376 MerR family regulatory protein 5 40 3.3E-9 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS16350 3ea0a0d185996a8e98e766ecd4e0ca7c 131 Gene3D G3DSA:1.10.1660.10 4 43 4.2E-6 T 09-03-2017 TK78_RS16350 3ea0a0d185996a8e98e766ecd4e0ca7c 131 TIGRFAM TIGR00638 Mop: molybdenum-pterin binding domain 66 128 1.3E-15 T 09-03-2017 IPR004606 Molybdenum-pterin binding GO:0006810|GO:0030151 TK78_RS16350 3ea0a0d185996a8e98e766ecd4e0ca7c 131 Gene3D G3DSA:2.40.50.100 66 128 9.5E-23 T 09-03-2017 TK78_RS16350 3ea0a0d185996a8e98e766ecd4e0ca7c 131 Pfam PF03459 TOBE domain 66 128 3.1E-18 T 09-03-2017 IPR005116 Transport-associated OB, type 1 TK78_RS16350 3ea0a0d185996a8e98e766ecd4e0ca7c 131 SUPERFAMILY SSF50331 66 129 4.86E-17 T 09-03-2017 IPR008995 Molybdate/tungstate binding, C-terminal TK78_RS30880 4b9eac6cbbe5f668f30f635244bc520a 404 Pfam PF13699 Domain of unknown function (DUF4157) 60 131 4.8E-26 T 09-03-2017 IPR025295 Domain of unknown function DUF4157 TK78_RS30880 4b9eac6cbbe5f668f30f635244bc520a 404 Gene3D G3DSA:3.90.1530.10 348 400 6.0E-4 T 09-03-2017 TK78_RS14780 073850489a48a34d1a5b87dfe2b069cb 249 Pfam PF03746 LamB/YcsF family 1 239 6.5E-96 T 09-03-2017 IPR005501 Uncharacterised protein family UPF0271, LamB/YcsF TK78_RS14780 073850489a48a34d1a5b87dfe2b069cb 249 SUPERFAMILY SSF88713 1 248 5.11E-92 T 09-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 TK78_RS14780 073850489a48a34d1a5b87dfe2b069cb 249 Hamap MF_00691 UPF0271 protein YbgL [ybgL]. 1 243 41.312 T 09-03-2017 IPR005501 Uncharacterised protein family UPF0271, LamB/YcsF TK78_RS08570 f1c117bc3307969f8160aefec85f7986 137 SUPERFAMILY SSF55874 40 132 3.96E-9 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS08570 f1c117bc3307969f8160aefec85f7986 137 Gene3D G3DSA:3.30.565.10 33 124 3.8E-5 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS08570 f1c117bc3307969f8160aefec85f7986 137 Pfam PF13581 Histidine kinase-like ATPase domain 21 130 1.5E-14 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS27360 9ed561137e160203530a233b386633f9 318 Gene3D G3DSA:3.40.30.10 86 258 7.7E-31 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS27360 9ed561137e160203530a233b386633f9 318 SUPERFAMILY SSF52833 82 246 9.86E-29 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS27360 9ed561137e160203530a233b386633f9 318 Pfam PF13462 Thioredoxin 85 256 1.2E-27 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS24750 579daa25d59db9e8188db3ee07df41a6 957 Gene3D G3DSA:3.40.50.2300 565 751 7.2E-7 T 09-03-2017 TK78_RS24750 579daa25d59db9e8188db3ee07df41a6 957 SUPERFAMILY SSF53822 567 831 9.42E-8 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS24750 579daa25d59db9e8188db3ee07df41a6 957 SUPERFAMILY SSF53822 863 912 9.42E-8 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS21375 8a1061d838056f5d67a66f83198bf8d0 440 Pfam PF07730 Histidine kinase 211 276 5.2E-17 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS21375 8a1061d838056f5d67a66f83198bf8d0 440 SUPERFAMILY SSF55874 317 435 4.51E-7 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS21800 7556016fdf66499bf1ad5d7f73a8633f 192 Pfam PF04138 GtrA-like protein 20 140 7.6E-23 T 09-03-2017 IPR007267 GtrA-like protein GO:0000271|GO:0006810|GO:0016021 TK78_RS17865 4946a2775810acecf427c06e3a223e7d 81 Pfam PF10944 Protein of unknown function (DUF2630) 3 80 1.8E-32 T 09-03-2017 IPR020311 Uncharacterised protein family, Rv0898c TK78_RS17865 4946a2775810acecf427c06e3a223e7d 81 ProDom PD062385 SCO7189 RV0898C/MT0921.1 MB0922C 3 79 4.0E-15 T 09-03-2017 IPR020311 Uncharacterised protein family, Rv0898c TK78_RS27310 61e29261d21c09b46bbb45c28979df1a 210 SUPERFAMILY SSF109854 12 114 6.04E-5 T 09-03-2017 TK78_RS27310 61e29261d21c09b46bbb45c28979df1a 210 Pfam PF07398 MDMPI C-terminal domain 117 202 2.8E-7 T 09-03-2017 IPR010872 MDMPI C-terminal TK78_RS27310 61e29261d21c09b46bbb45c28979df1a 210 TIGRFAM TIGR03085 TIGR03085: TIGR03085 family protein 5 203 6.6E-75 T 09-03-2017 IPR017519 Conserved hypothetical protein CHP03085 TK78_RS27310 61e29261d21c09b46bbb45c28979df1a 210 TIGRFAM TIGR03083 TIGR03083: uncharacterized Actinobacterial protein TIGR03083 5 185 5.6E-36 T 09-03-2017 IPR017517 Conserved hypothetical protein CHP03083, actinobacterial-type TK78_RS32920 6f691bb40bc647801ab981d82f23bf78 686 Pfam PF17048 Neutral/alkaline non-lysosomal ceramidase, C-terminal 526 685 5.6E-55 T 09-03-2017 IPR031331 Neutral/alkaline non-lysosomal ceramidase, C-terminal KEGG: 00600+3.5.1.23|MetaCyc: PWY-6483|MetaCyc: PWY-7119 TK78_RS32920 6f691bb40bc647801ab981d82f23bf78 686 Pfam PF04734 Neutral/alkaline non-lysosomal ceramidase, N-terminal 44 523 8.0E-179 T 09-03-2017 IPR031329 Neutral/alkaline non-lysosomal ceramidase, N-terminal KEGG: 00600+3.5.1.23|MetaCyc: PWY-6483|MetaCyc: PWY-7119|Reactome: R-HSA-1660662 TK78_RS07380 ea91f78ce6446eec00bbd823001f4640 388 Gene3D G3DSA:2.40.10.10 153 255 3.4E-7 T 09-03-2017 TK78_RS07380 ea91f78ce6446eec00bbd823001f4640 388 SUPERFAMILY SSF50494 131 368 7.71E-14 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS31875 dd045a46b329d07efa0d052d61139d0e 189 Gene3D G3DSA:1.10.10.10 123 165 1.3E-4 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS21260 8cd96be0737ede2e6e0eb7456f20008b 643 SUPERFAMILY SSF50998 254 643 4.55E-14 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS21260 8cd96be0737ede2e6e0eb7456f20008b 643 Pfam PF13360 PQQ-like domain 318 576 1.2E-7 T 09-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat TK78_RS10585 be89d8f8275eeba3dee8013fde4a6933 739 Pfam PF13361 UvrD-like helicase C-terminal domain 294 416 9.5E-15 T 09-03-2017 IPR014017 UvrD-like DNA helicase, C-terminal GO:0005524|GO:0016787 TK78_RS10585 be89d8f8275eeba3dee8013fde4a6933 739 Pfam PF13361 UvrD-like helicase C-terminal domain 458 566 1.8E-23 T 09-03-2017 IPR014017 UvrD-like DNA helicase, C-terminal GO:0005524|GO:0016787 TK78_RS10585 be89d8f8275eeba3dee8013fde4a6933 739 Pfam PF00580 UvrD/REP helicase N-terminal domain 24 99 1.1E-19 T 09-03-2017 IPR014016 UvrD-like Helicase, ATP-binding domain GO:0005524 TK78_RS10585 be89d8f8275eeba3dee8013fde4a6933 739 Pfam PF00580 UvrD/REP helicase N-terminal domain 172 286 1.0E-24 T 09-03-2017 IPR014016 UvrD-like Helicase, ATP-binding domain GO:0005524 TK78_RS10585 be89d8f8275eeba3dee8013fde4a6933 739 SUPERFAMILY SSF52540 17 586 7.31E-117 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10585 be89d8f8275eeba3dee8013fde4a6933 739 Gene3D G3DSA:1.10.150.80 655 720 3.2E-10 T 09-03-2017 IPR002121 HRDC domain GO:0003676|GO:0005622 TK78_RS10585 be89d8f8275eeba3dee8013fde4a6933 739 Pfam PF00570 HRDC domain 657 722 6.2E-16 T 09-03-2017 IPR002121 HRDC domain GO:0003676|GO:0005622 TK78_RS10585 be89d8f8275eeba3dee8013fde4a6933 739 Gene3D G3DSA:3.40.50.300 298 411 3.2E-54 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10585 be89d8f8275eeba3dee8013fde4a6933 739 Gene3D G3DSA:3.40.50.300 503 586 3.2E-54 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10585 be89d8f8275eeba3dee8013fde4a6933 739 Gene3D G3DSA:3.40.50.300 23 292 2.3E-63 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS10585 be89d8f8275eeba3dee8013fde4a6933 739 SUPERFAMILY SSF47819 646 725 1.2E-17 T 09-03-2017 IPR010997 HRDC-like GO:0000166|GO:0003824|GO:0044237 TK78_RS10585 be89d8f8275eeba3dee8013fde4a6933 739 SMART SM00341 653 733 2.6E-10 T 09-03-2017 IPR002121 HRDC domain GO:0003676|GO:0005622 TK78_RS25525 c847c9119f53ba577b1ec6a293cf6734 337 SUPERFAMILY SSF51430 8 317 2.36E-89 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS25525 c847c9119f53ba577b1ec6a293cf6734 337 Gene3D G3DSA:3.20.20.100 6 330 1.1E-100 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS25525 c847c9119f53ba577b1ec6a293cf6734 337 PRINTS PR00069 Aldo-keto reductase signature 113 131 2.9E-5 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS25525 c847c9119f53ba577b1ec6a293cf6734 337 PRINTS PR00069 Aldo-keto reductase signature 47 71 2.9E-5 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS25525 c847c9119f53ba577b1ec6a293cf6734 337 PRINTS PR00069 Aldo-keto reductase signature 144 161 2.9E-5 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS25525 c847c9119f53ba577b1ec6a293cf6734 337 Pfam PF00248 Aldo/keto reductase family 23 316 4.3E-65 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS22465 5bc7678167d46c33fc4a57c9a3b42acd 66 SUPERFAMILY SSF47598 3 42 1.59E-7 T 09-03-2017 IPR010985 Ribbon-helix-helix GO:0006355 TK78_RS22465 5bc7678167d46c33fc4a57c9a3b42acd 66 Pfam PF01402 Ribbon-helix-helix protein, copG family 5 40 3.9E-6 T 09-03-2017 IPR002145 Ribbon-helix-helix protein, CopG GO:0006355 TK78_RS22465 5bc7678167d46c33fc4a57c9a3b42acd 66 Gene3D G3DSA:1.10.1220.10 3 65 2.6E-9 T 09-03-2017 IPR013321 Arc-type ribbon-helix-helix GO:0006355 TK78_RS06560 c2e7322a5100f04ce8b5ae99c447f2b6 765 PRINTS PR00931 Microbial collagenase metalloprotease (M9) signature 469 485 3.3E-36 T 09-03-2017 IPR002169 Peptidase M9A/M9B, collagenase, bacterial GO:0004252|GO:0005576|GO:0006508|GO:0008270 TK78_RS06560 c2e7322a5100f04ce8b5ae99c447f2b6 765 PRINTS PR00931 Microbial collagenase metalloprotease (M9) signature 512 530 3.3E-36 T 09-03-2017 IPR002169 Peptidase M9A/M9B, collagenase, bacterial GO:0004252|GO:0005576|GO:0006508|GO:0008270 TK78_RS06560 c2e7322a5100f04ce8b5ae99c447f2b6 765 PRINTS PR00931 Microbial collagenase metalloprotease (M9) signature 177 195 3.3E-36 T 09-03-2017 IPR002169 Peptidase M9A/M9B, collagenase, bacterial GO:0004252|GO:0005576|GO:0006508|GO:0008270 TK78_RS06560 c2e7322a5100f04ce8b5ae99c447f2b6 765 PRINTS PR00931 Microbial collagenase metalloprotease (M9) signature 451 465 3.3E-36 T 09-03-2017 IPR002169 Peptidase M9A/M9B, collagenase, bacterial GO:0004252|GO:0005576|GO:0006508|GO:0008270 TK78_RS06560 c2e7322a5100f04ce8b5ae99c447f2b6 765 PRINTS PR00931 Microbial collagenase metalloprotease (M9) signature 535 550 3.3E-36 T 09-03-2017 IPR002169 Peptidase M9A/M9B, collagenase, bacterial GO:0004252|GO:0005576|GO:0006508|GO:0008270 TK78_RS06560 c2e7322a5100f04ce8b5ae99c447f2b6 765 Pfam PF01752 Collagenase 352 639 8.2E-122 T 09-03-2017 IPR002169 Peptidase M9A/M9B, collagenase, bacterial GO:0004252|GO:0005576|GO:0006508|GO:0008270 TK78_RS06560 c2e7322a5100f04ce8b5ae99c447f2b6 765 Pfam PF08453 Peptidase family M9 N-terminal 111 292 3.6E-69 T 09-03-2017 IPR013661 Peptidase M9, collagenase, N-terminal domain TK78_RS34355 51f5152650703b9b9c3addbd783c4327 194 Gene3D G3DSA:1.20.120.450 8 163 1.2E-34 T 09-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase TK78_RS34355 51f5152650703b9b9c3addbd783c4327 194 SUPERFAMILY SSF109854 6 159 3.82E-39 T 09-03-2017 TK78_RS34355 51f5152650703b9b9c3addbd783c4327 194 Pfam PF04978 Protein of unknown function (DUF664) 9 160 1.3E-47 T 09-03-2017 IPR007061 Protein of unknown function DUF664 TK78_RS28055 9fc07eafa5839174a728a91af631e0f3 217 Pfam PF14016 Protein of unknown function (DUF4232) 80 211 2.5E-18 T 09-03-2017 IPR025326 Protein of unknown function DUF4232 TK78_RS25050 c601b6da7bc4438e06912ce892ac9ba3 167 Pfam PF13302 Acetyltransferase (GNAT) domain 20 149 6.6E-16 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS25050 c601b6da7bc4438e06912ce892ac9ba3 167 SUPERFAMILY SSF55729 16 151 1.98E-26 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS25050 c601b6da7bc4438e06912ce892ac9ba3 167 Gene3D G3DSA:3.40.630.30 10 150 4.8E-23 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS31985 ef1f34869c2215aab590e60a79472051 199 SUPERFAMILY SSF56524 18 198 2.22E-57 T 09-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 TK78_RS31985 ef1f34869c2215aab590e60a79472051 199 Pfam PF00174 Oxidoreductase molybdopterin binding domain 35 179 3.0E-30 T 09-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 TK78_RS31985 ef1f34869c2215aab590e60a79472051 199 Gene3D G3DSA:3.90.420.10 25 196 8.2E-47 T 09-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 TK78_RS27885 4cf9d385b53521731553faa1299d51b0 77 PRINTS PR01651 Protein-export SecG membrane protein signature 54 76 7.5E-7 T 09-03-2017 IPR004692 Preprotein translocase SecG subunit GO:0009306|GO:0015450|GO:0016021 TK78_RS27885 4cf9d385b53521731553faa1299d51b0 77 PRINTS PR01651 Protein-export SecG membrane protein signature 3 23 7.5E-7 T 09-03-2017 IPR004692 Preprotein translocase SecG subunit GO:0009306|GO:0015450|GO:0016021 TK78_RS27885 4cf9d385b53521731553faa1299d51b0 77 PRINTS PR01651 Protein-export SecG membrane protein signature 23 37 7.5E-7 T 09-03-2017 IPR004692 Preprotein translocase SecG subunit GO:0009306|GO:0015450|GO:0016021 TK78_RS27885 4cf9d385b53521731553faa1299d51b0 77 PRINTS PR01651 Protein-export SecG membrane protein signature 38 54 7.5E-7 T 09-03-2017 IPR004692 Preprotein translocase SecG subunit GO:0009306|GO:0015450|GO:0016021 TK78_RS27885 4cf9d385b53521731553faa1299d51b0 77 Pfam PF03840 Preprotein translocase SecG subunit 5 73 3.9E-20 T 09-03-2017 IPR004692 Preprotein translocase SecG subunit GO:0009306|GO:0015450|GO:0016021 TK78_RS27885 4cf9d385b53521731553faa1299d51b0 77 TIGRFAM TIGR00810 secG: preprotein translocase, SecG subunit 3 73 4.0E-21 T 09-03-2017 IPR004692 Preprotein translocase SecG subunit GO:0009306|GO:0015450|GO:0016021 TK78_RS19260 8b7d4f9a5ba1b7e5f31e0230afd71269 74 SMART SM00923 1 50 6.6E-18 T 09-03-2017 IPR005153 MbtH-like protein TK78_RS19260 8b7d4f9a5ba1b7e5f31e0230afd71269 74 Gene3D G3DSA:3.90.820.10 7 63 9.7E-27 T 09-03-2017 TK78_RS19260 8b7d4f9a5ba1b7e5f31e0230afd71269 74 SUPERFAMILY SSF160582 3 65 4.45E-24 T 09-03-2017 TK78_RS19260 8b7d4f9a5ba1b7e5f31e0230afd71269 74 Pfam PF03621 MbtH-like protein 2 48 5.7E-18 T 09-03-2017 IPR005153 MbtH-like protein TK78_RS04150 aa0330c89ac2833d724a72671f7741d3 495 Gene3D G3DSA:3.40.50.1820 277 278 2.2E-11 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04150 aa0330c89ac2833d724a72671f7741d3 495 Gene3D G3DSA:3.40.50.1820 95 202 2.2E-11 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04150 aa0330c89ac2833d724a72671f7741d3 495 Gene3D G3DSA:3.40.50.1820 335 396 2.2E-11 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04150 aa0330c89ac2833d724a72671f7741d3 495 SUPERFAMILY SSF53474 335 393 2.53E-16 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS04150 aa0330c89ac2833d724a72671f7741d3 495 SUPERFAMILY SSF53474 52 204 2.53E-16 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS07520 185ac21742f706f05fb52603d6733edc 304 SUPERFAMILY SSF48239 249 301 2.01E-7 T 09-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid TK78_RS07520 185ac21742f706f05fb52603d6733edc 304 SUPERFAMILY SSF48239 44 151 2.01E-7 T 09-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid TK78_RS07520 185ac21742f706f05fb52603d6733edc 304 Gene3D G3DSA:1.50.10.20 249 302 3.4E-4 T 09-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid TK78_RS31900 33454aef39d1bb49ffd81a3413c4f2dc 422 PRINTS PR00723 Subtilisin serine protease family (S8) signature 296 312 2.0E-7 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS31900 33454aef39d1bb49ffd81a3413c4f2dc 422 PRINTS PR00723 Subtilisin serine protease family (S8) signature 131 144 2.0E-7 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS31900 33454aef39d1bb49ffd81a3413c4f2dc 422 PRINTS PR00723 Subtilisin serine protease family (S8) signature 99 118 2.0E-7 T 09-03-2017 IPR015500 Peptidase S8, subtilisin-related TK78_RS31900 33454aef39d1bb49ffd81a3413c4f2dc 422 SUPERFAMILY SSF52743 79 347 2.09E-38 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS31900 33454aef39d1bb49ffd81a3413c4f2dc 422 Pfam PF00082 Subtilase family 99 334 6.0E-12 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS31900 33454aef39d1bb49ffd81a3413c4f2dc 422 Gene3D G3DSA:3.40.50.200 74 347 1.2E-38 T 09-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 TK78_RS08340 dd640dd9747ef50830412da551ef4edc 250 SMART SM00563 41 159 3.6E-32 T 09-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 TK78_RS08340 dd640dd9747ef50830412da551ef4edc 250 Gene3D G3DSA:3.40.1130.10 32 223 2.6E-20 T 09-03-2017 TK78_RS08340 dd640dd9747ef50830412da551ef4edc 250 SUPERFAMILY SSF69593 4 231 3.01E-42 T 09-03-2017 TK78_RS08340 dd640dd9747ef50830412da551ef4edc 250 Pfam PF01553 Acyltransferase 30 155 6.8E-21 T 09-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 TK78_RS17500 fb400a57f0ecb4eb5421d881b37141f4 457 SUPERFAMILY SSF63817 298 444 7.72E-29 T 09-03-2017 IPR023365 Sortase domain TK78_RS17500 fb400a57f0ecb4eb5421d881b37141f4 457 Pfam PF04203 Sortase family 305 442 1.2E-25 T 09-03-2017 IPR005754 Sortase family TK78_RS17500 fb400a57f0ecb4eb5421d881b37141f4 457 TIGRFAM TIGR01076 sortase_fam: sortase 304 442 4.4E-15 T 09-03-2017 IPR005754 Sortase family TK78_RS17500 fb400a57f0ecb4eb5421d881b37141f4 457 Gene3D G3DSA:2.40.260.10 300 445 3.3E-27 T 09-03-2017 IPR023365 Sortase domain TK78_RS26160 e27be83c7152daeeda64617c8735dac2 225 Gene3D G3DSA:3.10.310.10 11 121 4.4E-16 T 09-03-2017 TK78_RS26160 e27be83c7152daeeda64617c8735dac2 225 Pfam PF02567 Phenazine biosynthesis-like protein 24 89 1.7E-9 T 09-03-2017 IPR003719 Phenazine biosynthesis PhzF protein GO:0003824|GO:0009058 TK78_RS26160 e27be83c7152daeeda64617c8735dac2 225 SUPERFAMILY SSF54506 10 225 2.36E-28 T 09-03-2017 TK78_RS26160 e27be83c7152daeeda64617c8735dac2 225 Gene3D G3DSA:3.10.310.10 130 218 5.4E-9 T 09-03-2017 TK78_RS31565 b7198ac6e16806f55b0f1eaf24c3026e 143 Gene3D G3DSA:3.30.565.10 25 137 1.7E-10 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS31565 b7198ac6e16806f55b0f1eaf24c3026e 143 SUPERFAMILY SSF55874 33 137 2.1E-13 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS31565 b7198ac6e16806f55b0f1eaf24c3026e 143 Pfam PF13581 Histidine kinase-like ATPase domain 11 131 7.5E-13 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS23615 8f847682fcef99aa5865a0d48bb1abb9 73 Pfam PF13340 Putative transposase of IS4/5 family (DUF4096) 1 73 1.9E-25 T 09-03-2017 IPR025161 Putative transposase IS4/IS5 family TK78_RS06205 f99942d5b2f95c748589148dfacce037 675 Pfam PF02653 Branched-chain amino acid transport system / permease component 367 611 1.0E-27 T 09-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 TK78_RS06205 f99942d5b2f95c748589148dfacce037 675 Pfam PF02653 Branched-chain amino acid transport system / permease component 14 277 1.0E-27 T 09-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 TK78_RS18785 dd89b48d8bcd8b2769e02cb9398cb5fa 202 TIGRFAM TIGR03083 TIGR03083: uncharacterized Actinobacterial protein TIGR03083 2 182 2.6E-32 T 09-03-2017 IPR017517 Conserved hypothetical protein CHP03083, actinobacterial-type TK78_RS18785 dd89b48d8bcd8b2769e02cb9398cb5fa 202 Gene3D G3DSA:1.20.120.450 3 98 2.5E-9 T 09-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase TK78_RS18785 dd89b48d8bcd8b2769e02cb9398cb5fa 202 SUPERFAMILY SSF109854 2 118 1.85E-18 T 09-03-2017 TK78_RS18785 dd89b48d8bcd8b2769e02cb9398cb5fa 202 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 3 131 3.9E-14 T 09-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 TK78_RS24840 dcd0094ad6ebc1b6fb4394d33ee79ed1 120 SUPERFAMILY SSF53927 15 114 1.84E-12 T 09-03-2017 IPR016193 Cytidine deaminase-like GO:0003824 TK78_RS24840 dcd0094ad6ebc1b6fb4394d33ee79ed1 120 Gene3D G3DSA:3.40.140.10 7 115 4.0E-9 T 09-03-2017 TK78_RS28165 55bd5189b06aaafa04d46a12415a9576 356 Pfam PF00724 NADH:flavin oxidoreductase / NADH oxidase family 4 330 1.9E-72 T 09-03-2017 IPR001155 NADH:flavin oxidoreductase/NADH oxidase, N-terminal GO:0010181|GO:0016491|GO:0055114 TK78_RS28165 55bd5189b06aaafa04d46a12415a9576 356 Gene3D G3DSA:3.20.20.70 2 352 9.6E-116 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS28165 55bd5189b06aaafa04d46a12415a9576 356 SUPERFAMILY SSF51395 1 354 8.64E-110 T 09-03-2017 TK78_RS01575 a5453a0f4941b6b82274d8c061e9f6e6 99 Pfam PF09860 Uncharacterized protein conserved in bacteria (DUF2087) 28 97 6.4E-23 T 09-03-2017 IPR018656 Domain of unknown function DUF2087 TK78_RS22030 ea740f7f020bda6de05948c895b67549 343 Pfam PF06271 RDD family 18 144 8.4E-16 T 09-03-2017 IPR010432 RDD TK78_RS24170 3eb1f701eb6972a5e0d31dc5c28188de 178 Pfam PF14279 HNH endonuclease 83 129 3.7E-14 T 09-03-2017 IPR029471 HNH endonuclease 5 TK78_RS24170 3eb1f701eb6972a5e0d31dc5c28188de 178 SMART SM00507 70 119 5.1E-14 T 09-03-2017 IPR003615 HNH nuclease TK78_RS16300 7a7ae8381dcd9846547a0eddf53ed4df 428 Gene3D G3DSA:3.30.565.10 188 295 1.8E-7 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS16300 7a7ae8381dcd9846547a0eddf53ed4df 428 SUPERFAMILY SSF55874 170 297 2.23E-11 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS07345 96dc780af1b2aaca0722efd324649931 170 TIGRFAM TIGR00244 TIGR00244: transcriptional regulator NrdR 1 143 4.2E-45 T 09-03-2017 IPR003796 Ribonucleotide reductase regulator NrdR-like GO:0008270|GO:0045892 TK78_RS07345 96dc780af1b2aaca0722efd324649931 170 Pfam PF03477 ATP cone domain 47 132 5.5E-13 T 09-03-2017 IPR005144 ATP-cone domain Reactome: R-HSA-499943 TK78_RS07345 96dc780af1b2aaca0722efd324649931 170 Hamap MF_00440 Transcriptional repressor NrdR [nrdR]. 1 150 75.974 T 09-03-2017 IPR003796 Ribonucleotide reductase regulator NrdR-like GO:0008270|GO:0045892 TK78_RS21930 7371f2d29c63a0f9db5b9bec90ba8ae3 521 TIGRFAM TIGR00350 lytR_cpsA_psr: cell envelope-related function transcriptional attenuator common domain 231 386 6.8E-49 T 09-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain TK78_RS21930 7371f2d29c63a0f9db5b9bec90ba8ae3 521 Pfam PF03816 Cell envelope-related transcriptional attenuator domain 231 386 3.0E-52 T 09-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain TK78_RS18795 c422035ab45e414b630fe42f374e7d7e 314 Gene3D G3DSA:3.20.20.190 55 311 1.4E-60 T 09-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 TK78_RS18795 c422035ab45e414b630fe42f374e7d7e 314 SMART SM00148 65 204 2.0E-6 T 09-03-2017 IPR000909 Phosphatidylinositol-specific phospholipase C, X domain TK78_RS18795 c422035ab45e414b630fe42f374e7d7e 314 Pfam PF00388 Phosphatidylinositol-specific phospholipase C, X domain 88 201 1.3E-9 T 09-03-2017 IPR000909 Phosphatidylinositol-specific phospholipase C, X domain TK78_RS18795 c422035ab45e414b630fe42f374e7d7e 314 SUPERFAMILY SSF51695 56 311 1.73E-50 T 09-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 TK78_RS18005 4ab625bfb80f458d196baffd72ad193c 434 SUPERFAMILY SSF55124 23 104 9.65E-20 T 09-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TK78_RS18005 4ab625bfb80f458d196baffd72ad193c 434 Gene3D G3DSA:3.90.480.10 36 105 1.6E-22 T 09-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TK78_RS18005 4ab625bfb80f458d196baffd72ad193c 434 Gene3D G3DSA:3.90.480.10 256 332 1.6E-22 T 09-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TK78_RS18005 4ab625bfb80f458d196baffd72ad193c 434 SUPERFAMILY SSF55124 211 332 5.98E-21 T 09-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TK78_RS18005 4ab625bfb80f458d196baffd72ad193c 434 Pfam PF03460 Nitrite/Sulfite reductase ferredoxin-like half domain 41 87 3.5E-11 T 09-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TK78_RS18005 4ab625bfb80f458d196baffd72ad193c 434 Pfam PF03460 Nitrite/Sulfite reductase ferredoxin-like half domain 271 312 6.2E-9 T 09-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TK78_RS25665 540a417b2b2f22fcfbd429ac7ab3aaf8 269 Pfam PF13349 Putative adhesin 141 258 1.2E-11 T 09-03-2017 IPR025164 Putative adhesin TK78_RS05570 397c49e190fd1a0868a4573e4432b6a9 503 SUPERFAMILY SSF53474 89 146 1.93E-24 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS05570 397c49e190fd1a0868a4573e4432b6a9 503 SUPERFAMILY SSF53474 192 307 1.93E-24 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS05570 397c49e190fd1a0868a4573e4432b6a9 503 SUPERFAMILY SSF53474 390 473 1.93E-24 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS05570 397c49e190fd1a0868a4573e4432b6a9 503 Gene3D G3DSA:3.40.50.1820 190 314 1.4E-57 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS05570 397c49e190fd1a0868a4573e4432b6a9 503 Gene3D G3DSA:3.40.50.1820 59 145 1.4E-57 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS05570 397c49e190fd1a0868a4573e4432b6a9 503 Gene3D G3DSA:3.40.50.1820 368 488 1.4E-57 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS05570 397c49e190fd1a0868a4573e4432b6a9 503 Pfam PF00561 alpha/beta hydrolase fold 95 475 4.6E-25 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS34230 dad6270454b1f4e8402352db8ad950dd 366 Pfam PF06224 Winged helix DNA-binding domain 31 350 2.0E-70 T 09-03-2017 IPR009351 Protein of unknown function DUF1006 TK78_RS28095 0a002a4defd2cdd7bcf1c7275612f8c7 421 Pfam PF07690 Major Facilitator Superfamily 21 372 1.4E-18 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS28095 0a002a4defd2cdd7bcf1c7275612f8c7 421 SUPERFAMILY SSF103473 13 414 5.49E-29 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS28095 0a002a4defd2cdd7bcf1c7275612f8c7 421 Gene3D G3DSA:1.20.1250.20 240 410 2.3E-8 T 09-03-2017 TK78_RS28095 0a002a4defd2cdd7bcf1c7275612f8c7 421 Gene3D G3DSA:1.20.1250.20 12 193 7.6E-16 T 09-03-2017 TK78_RS33585 344e4dc2d4415feeb22ec009218177c5 447 SUPERFAMILY SSF63829 78 196 1.18E-5 T 09-03-2017 TK78_RS14600 1bd23050badeba60f43015e048909774 444 Gene3D G3DSA:1.20.1250.20 238 413 1.4E-12 T 09-03-2017 TK78_RS14600 1bd23050badeba60f43015e048909774 444 Gene3D G3DSA:1.20.1250.20 35 214 2.9E-17 T 09-03-2017 TK78_RS14600 1bd23050badeba60f43015e048909774 444 SUPERFAMILY SSF103473 31 416 4.71E-45 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS14600 1bd23050badeba60f43015e048909774 444 Pfam PF05977 Transmembrane secretion effector 23 411 2.8E-52 T 09-03-2017 IPR010290 Transmembrane secretion effector TK78_RS20190 1a558a00ed815935636d2a26e2de8821 244 Pfam PF01927 Mut7-C RNAse domain 90 231 9.4E-40 T 09-03-2017 IPR002782 Mut7-C RNAse domain TK78_RS20190 1a558a00ed815935636d2a26e2de8821 244 Pfam PF14451 Mut7-C ubiquitin 4 82 1.4E-21 T 09-03-2017 IPR027798 Ubiquitin Mut7-C domain TK78_RS29260 4feefb1a18963a95fafde29882f6b408 353 Pfam PF09754 PAC2 family 19 236 1.2E-51 T 09-03-2017 IPR019151 Proteasome assembly chaperone 2 TK78_RS29260 4feefb1a18963a95fafde29882f6b408 353 SUPERFAMILY SSF159659 3 260 1.44E-88 T 09-03-2017 TK78_RS28715 fcdc158589030e1d8d27eb24e2bea1db 200 Gene3D G3DSA:1.10.357.10 11 188 2.2E-18 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS28715 fcdc158589030e1d8d27eb24e2bea1db 200 Pfam PF00440 Bacterial regulatory proteins, tetR family 28 58 1.7E-5 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS28715 fcdc158589030e1d8d27eb24e2bea1db 200 SUPERFAMILY SSF46689 11 82 2.99E-12 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS03945 bb0069ff8e493c7748cf3b202fbe791e 344 SUPERFAMILY SSF53822 49 339 3.2E-61 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS03945 bb0069ff8e493c7748cf3b202fbe791e 344 Pfam PF13407 Periplasmic binding protein domain 52 306 6.6E-44 T 09-03-2017 IPR025997 Periplasmic binding protein TK78_RS03945 bb0069ff8e493c7748cf3b202fbe791e 344 Gene3D G3DSA:3.40.50.2300 170 339 2.2E-36 T 09-03-2017 TK78_RS03945 bb0069ff8e493c7748cf3b202fbe791e 344 Gene3D G3DSA:3.40.50.2300 46 169 4.1E-27 T 09-03-2017 TK78_RS19090 6e42f3a801e7f8d83fb82b2fc6977e57 221 Pfam PF00583 Acetyltransferase (GNAT) family 88 178 6.7E-12 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS19090 6e42f3a801e7f8d83fb82b2fc6977e57 221 SUPERFAMILY SSF55729 34 194 9.96E-22 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS19090 6e42f3a801e7f8d83fb82b2fc6977e57 221 Gene3D G3DSA:3.40.630.30 32 178 6.8E-21 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS09200 807613fc43e55f8ef4c0728cdc37c59f 451 Gene3D G3DSA:2.60.120.260 319 448 4.6E-7 T 09-03-2017 IPR008979 Galactose-binding domain-like TK78_RS06335 ccd5f3fd86ef8d3c50c764b1bd7d1315 246 ProSitePatterns PS00379 CDP-alcohol phosphatidyltransferases signature. 92 114 - T 09-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 TK78_RS06335 ccd5f3fd86ef8d3c50c764b1bd7d1315 246 Pfam PF01066 CDP-alcohol phosphatidyltransferase 46 114 4.4E-9 T 09-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 TK78_RS29830 3bd6acd7bbd8191ba70d5975e272c8bc 427 SUPERFAMILY SSF48371 234 300 3.2E-11 T 09-03-2017 IPR016024 Armadillo-type fold GO:0005488 TK78_RS29830 3bd6acd7bbd8191ba70d5975e272c8bc 427 SUPERFAMILY SSF48371 330 382 3.2E-11 T 09-03-2017 IPR016024 Armadillo-type fold GO:0005488 TK78_RS29830 3bd6acd7bbd8191ba70d5975e272c8bc 427 SUPERFAMILY SSF48371 82 136 3.2E-11 T 09-03-2017 IPR016024 Armadillo-type fold GO:0005488 TK78_RS29830 3bd6acd7bbd8191ba70d5975e272c8bc 427 Gene3D G3DSA:1.25.10.10 220 381 1.1E-6 T 09-03-2017 IPR011989 Armadillo-like helical TK78_RS26940 2cddcc0439d130f0fcf2bc6cbb77edb1 210 Gene3D G3DSA:3.90.420.10 12 199 4.4E-45 T 09-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 TK78_RS26940 2cddcc0439d130f0fcf2bc6cbb77edb1 210 Pfam PF00174 Oxidoreductase molybdopterin binding domain 33 181 3.8E-28 T 09-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 TK78_RS26940 2cddcc0439d130f0fcf2bc6cbb77edb1 210 SUPERFAMILY SSF56524 15 203 4.84E-54 T 09-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 TK78_RS24340 44b48868099b73283a2ccccd4c1db379 197 Pfam PF02632 BioY family 52 191 4.7E-33 T 09-03-2017 IPR003784 BioY protein GO:0005886|GO:0015225|GO:0015878 TK78_RS24340 44b48868099b73283a2ccccd4c1db379 197 PIRSF PIRSF016661 15 197 2.2E-38 T 09-03-2017 IPR003784 BioY protein GO:0005886|GO:0015225|GO:0015878 TK78_RS08120 fe531df048bc08ba9f2eec8880b3674e 102 Pfam PF10611 Protein of unknown function (DUF2469) 1 100 1.4E-52 T 09-03-2017 IPR019592 Protein of unknown function DUF2469 TK78_RS24985 e10fd1997189e3b75ab14042a4eba9c4 328 Gene3D G3DSA:1.10.10.60 239 272 2.9E-4 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS24985 e10fd1997189e3b75ab14042a4eba9c4 328 Pfam PF12625 Arabinose-binding domain of AraC transcription regulator, N-term 12 196 1.5E-23 T 09-03-2017 IPR032687 HTH-type transcriptional regulator AraC-type, N-terminal TK78_RS04145 7c14e073cc1fc33d019fa0cdb88d28f5 422 Gene3D G3DSA:3.40.630.20 170 418 8.2E-11 T 09-03-2017 IPR016125 Peptidase C15, pyroglutamyl peptidase I-like TK78_RS04145 7c14e073cc1fc33d019fa0cdb88d28f5 422 SUPERFAMILY SSF53182 171 311 2.22E-26 T 09-03-2017 TK78_RS04145 7c14e073cc1fc33d019fa0cdb88d28f5 422 SUPERFAMILY SSF53182 339 418 2.22E-26 T 09-03-2017 TK78_RS03905 c4d0a049fd18ccf71c5f69620e93f93f 282 PIRSF PIRSF005295 2 259 2.8E-101 T 09-03-2017 IPR012022 Protein of unknown function UCP005295 TK78_RS03905 c4d0a049fd18ccf71c5f69620e93f93f 282 Gene3D G3DSA:3.20.20.140 4 255 5.9E-33 T 09-03-2017 TK78_RS03905 c4d0a049fd18ccf71c5f69620e93f93f 282 SUPERFAMILY SSF51556 2 256 8.72E-51 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS03905 c4d0a049fd18ccf71c5f69620e93f93f 282 Pfam PF01026 TatD related DNase 4 235 2.1E-12 T 09-03-2017 IPR001130 TatD family GO:0016788 TK78_RS19590 4507e34c33af1568c8bb84d79e1ac926 433 Gene3D G3DSA:1.10.3080.10 25 413 2.6E-21 T 09-03-2017 IPR014743 Chloride channel, core GO:0005216|GO:0055085 Reactome: R-HSA-2672351 TK78_RS19590 4507e34c33af1568c8bb84d79e1ac926 433 Pfam PF00654 Voltage gated chloride channel 96 413 1.4E-22 T 09-03-2017 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 Reactome: R-HSA-2672351 TK78_RS19590 4507e34c33af1568c8bb84d79e1ac926 433 SUPERFAMILY SSF81340 27 417 6.28E-39 T 09-03-2017 IPR014743 Chloride channel, core GO:0005216|GO:0055085 Reactome: R-HSA-2672351 TK78_RS19590 4507e34c33af1568c8bb84d79e1ac926 433 PRINTS PR00762 Chloride channel signature 386 402 1.3E-6 T 09-03-2017 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 Reactome: R-HSA-2672351 TK78_RS19590 4507e34c33af1568c8bb84d79e1ac926 433 PRINTS PR00762 Chloride channel signature 120 139 1.3E-6 T 09-03-2017 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 Reactome: R-HSA-2672351 TK78_RS19590 4507e34c33af1568c8bb84d79e1ac926 433 PRINTS PR00762 Chloride channel signature 339 359 1.3E-6 T 09-03-2017 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 Reactome: R-HSA-2672351 TK78_RS19590 4507e34c33af1568c8bb84d79e1ac926 433 PRINTS PR00762 Chloride channel signature 170 189 1.3E-6 T 09-03-2017 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 Reactome: R-HSA-2672351 TK78_RS19040 80c75df5d6c6b021562ee1c8a827ccf0 253 TIGRFAM TIGR01258 pgm_1: phosphoglycerate mutase 1 family 7 251 7.1E-111 T 09-03-2017 IPR005952 Phosphoglycerate mutase 1 GO:0004619|GO:0006096|GO:0016868 KEGG: 00010+5.4.2.11|KEGG: 00260+5.4.2.11|KEGG: 00680+5.4.2.11|MetaCyc: PWY-1622|MetaCyc: PWY-5484 TK78_RS19040 80c75df5d6c6b021562ee1c8a827ccf0 253 SUPERFAMILY SSF53254 6 225 1.81E-70 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS19040 80c75df5d6c6b021562ee1c8a827ccf0 253 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 8 127 4.7E-25 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS19040 80c75df5d6c6b021562ee1c8a827ccf0 253 Hamap MF_01039 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [gpmA]. 5 234 42.313 T 09-03-2017 IPR005952 Phosphoglycerate mutase 1 GO:0004619|GO:0006096|GO:0016868 KEGG: 00010+5.4.2.11|KEGG: 00260+5.4.2.11|KEGG: 00680+5.4.2.11|MetaCyc: PWY-1622|MetaCyc: PWY-5484 TK78_RS19040 80c75df5d6c6b021562ee1c8a827ccf0 253 SMART SM00855 7 193 1.4E-22 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS19040 80c75df5d6c6b021562ee1c8a827ccf0 253 ProSitePatterns PS00175 Phosphoglycerate mutase family phosphohistidine signature. 10 19 - T 09-03-2017 IPR001345 Phosphoglycerate/bisphosphoglycerate mutase, active site GO:0003824|GO:0008152 TK78_RS19040 80c75df5d6c6b021562ee1c8a827ccf0 253 Gene3D G3DSA:3.40.50.1240 5 253 1.7E-86 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS05380 0abdd5af60011be7219917081b758765 77 Pfam PF03777 Small secreted domain (DUF320) 21 76 4.7E-28 T 09-03-2017 IPR005528 Domain of unknown function DUF320, Streptomyces species TK78_RS00755 596180f21fdb3aebca30954a0d0c51a0 300 SUPERFAMILY SSF52266 48 298 9.49E-65 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS00755 596180f21fdb3aebca30954a0d0c51a0 300 Gene3D G3DSA:3.40.50.1110 46 298 1.5E-74 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS00755 596180f21fdb3aebca30954a0d0c51a0 300 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 53 288 5.0E-27 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS11375 464d40d36db95f3da376c6083dd9cde9 180 Pfam PF14030 Protein of unknown function (DUF4245) 5 169 3.2E-49 T 09-03-2017 IPR025339 Protein of unknown function DUF4245 TK78_RS32765 580d43664cb2f18331acc6b8fd3759da 228 Gene3D G3DSA:3.60.15.10 2 220 8.7E-44 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS32765 580d43664cb2f18331acc6b8fd3759da 228 SMART SM00849 17 209 3.5E-28 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS32765 580d43664cb2f18331acc6b8fd3759da 228 Pfam PF00753 Metallo-beta-lactamase superfamily 15 209 2.7E-28 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS32765 580d43664cb2f18331acc6b8fd3759da 228 SUPERFAMILY SSF56281 4 219 6.63E-47 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS06320 c04b5c065bf5a2e61a69a6b41a6e14ad 563 SUPERFAMILY SSF52540 348 513 1.21E-10 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS06320 c04b5c065bf5a2e61a69a6b41a6e14ad 563 Gene3D G3DSA:3.40.50.300 348 511 2.1E-9 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS16200 e09defc00426c343a6c0b91dc2e180d7 112 Gene3D G3DSA:3.40.30.10 11 111 4.0E-13 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS16200 e09defc00426c343a6c0b91dc2e180d7 112 SUPERFAMILY SSF52833 10 112 8.33E-17 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS16200 e09defc00426c343a6c0b91dc2e180d7 112 Pfam PF00085 Thioredoxin 10 111 1.7E-9 T 09-03-2017 IPR013766 Thioredoxin domain GO:0045454 TK78_RS22630 036de4146127ffd5f6d540dc517c632b 175 SUPERFAMILY SSF50118 70 171 1.11E-11 T 09-03-2017 IPR011067 Plasmid maintenance toxin/Cell growth inhibitor TK78_RS22630 036de4146127ffd5f6d540dc517c632b 175 Pfam PF02452 PemK-like, MazF-like toxin of type II toxin-antitoxin system 72 170 1.0E-10 T 09-03-2017 IPR003477 mRNA interferase PemK-like protein GO:0003677 TK78_RS22630 036de4146127ffd5f6d540dc517c632b 175 Gene3D G3DSA:2.30.30.110 69 171 5.6E-8 T 09-03-2017 IPR011067 Plasmid maintenance toxin/Cell growth inhibitor TK78_RS29225 203ce5fe6699356fe4aaa242bf517294 262 SUPERFAMILY SSF47240 15 193 2.59E-9 T 09-03-2017 IPR009078 Ferritin-like superfamily TK78_RS22665 706c7c8c14387ac44d9ab8641415f41d 129 Gene3D G3DSA:1.10.287.950 39 106 6.8E-5 T 09-03-2017 TK78_RS25940 1d5e699fb33c3b08475ca3d3791537f8 526 SUPERFAMILY SSF103473 259 472 3.92E-56 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS25940 1d5e699fb33c3b08475ca3d3791537f8 526 SUPERFAMILY SSF103473 24 213 3.92E-56 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS25940 1d5e699fb33c3b08475ca3d3791537f8 526 Pfam PF07690 Major Facilitator Superfamily 29 423 1.5E-40 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS25940 1d5e699fb33c3b08475ca3d3791537f8 526 Gene3D G3DSA:1.20.1250.20 274 479 9.8E-21 T 09-03-2017 TK78_RS25940 1d5e699fb33c3b08475ca3d3791537f8 526 Gene3D G3DSA:1.20.1250.20 19 205 2.4E-29 T 09-03-2017 TK78_RS27965 a19e119875e87c64b49a6cf0e92e836e 255 Pfam PF01061 ABC-2 type transporter 28 222 3.5E-23 T 09-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 TK78_RS27965 a19e119875e87c64b49a6cf0e92e836e 255 PIRSF PIRSF006648 2 254 1.4E-32 T 09-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 TK78_RS01725 c0be87dbb4c01ea688b0da92aeac9f44 328 Pfam PF01497 Periplasmic binding protein 76 305 2.9E-19 T 09-03-2017 IPR002491 ABC transporter periplasmic binding domain GO:0005488 TK78_RS01725 c0be87dbb4c01ea688b0da92aeac9f44 328 SUPERFAMILY SSF53807 59 320 5.89E-40 T 09-03-2017 TK78_RS01725 c0be87dbb4c01ea688b0da92aeac9f44 328 Gene3D G3DSA:3.40.50.1980 58 166 3.8E-16 T 09-03-2017 TK78_RS01725 c0be87dbb4c01ea688b0da92aeac9f44 328 Gene3D G3DSA:3.40.50.1980 167 327 4.5E-18 T 09-03-2017 TK78_RS01345 41fa6f6c6f1f2896135775e4bf530cf1 338 Pfam PF01494 FAD binding domain 2 277 2.9E-13 T 09-03-2017 IPR002938 FAD-binding domain GO:0071949 TK78_RS01345 41fa6f6c6f1f2896135775e4bf530cf1 338 Gene3D G3DSA:3.50.50.60 243 280 4.8E-29 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS01345 41fa6f6c6f1f2896135775e4bf530cf1 338 Gene3D G3DSA:3.50.50.60 3 154 4.8E-29 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS01345 41fa6f6c6f1f2896135775e4bf530cf1 338 SUPERFAMILY SSF51905 3 151 3.17E-35 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS01345 41fa6f6c6f1f2896135775e4bf530cf1 338 SUPERFAMILY SSF51905 232 307 3.17E-35 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS01345 41fa6f6c6f1f2896135775e4bf530cf1 338 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 3 25 2.5E-15 T 09-03-2017 TK78_RS01345 41fa6f6c6f1f2896135775e4bf530cf1 338 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 245 260 2.5E-15 T 09-03-2017 TK78_RS01345 41fa6f6c6f1f2896135775e4bf530cf1 338 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 130 145 2.5E-15 T 09-03-2017 TK78_RS25620 4b21a401f4f31422a965fdc463fc3458 383 Pfam PF04332 Protein of unknown function (DUF475) 44 362 8.5E-136 T 09-03-2017 IPR007427 Protein of unknown function DUF475 TK78_RS17685 d08e30e0c6489c05ceea03a6402728d1 207 SUPERFAMILY SSF46785 3 172 3.38E-31 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS17685 d08e30e0c6489c05ceea03a6402728d1 207 Pfam PF03551 Transcriptional regulator PadR-like family 7 77 1.8E-15 T 09-03-2017 IPR005149 Transcription regulator PadR, N-terminal TK78_RS17685 d08e30e0c6489c05ceea03a6402728d1 207 Pfam PF10400 Virulence activator alpha C-term 91 172 4.0E-11 T 09-03-2017 IPR018309 Transcription regulator PadR, C-terminal TK78_RS17685 d08e30e0c6489c05ceea03a6402728d1 207 Gene3D G3DSA:1.10.10.10 1 84 1.7E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS32775 8bf8643db050529b5c42d1e1beb7c20d 404 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 159 174 7.9E-12 T 09-03-2017 TK78_RS32775 8bf8643db050529b5c42d1e1beb7c20d 404 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 278 293 7.9E-12 T 09-03-2017 TK78_RS32775 8bf8643db050529b5c42d1e1beb7c20d 404 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 19 41 7.9E-12 T 09-03-2017 TK78_RS32775 8bf8643db050529b5c42d1e1beb7c20d 404 TIGRFAM TIGR02032 GG-red-SF: geranylgeranyl reductase family 18 313 1.6E-78 T 09-03-2017 IPR011777 Geranylgeranyl reductase family GO:0016628|GO:0055114 TK78_RS32775 8bf8643db050529b5c42d1e1beb7c20d 404 Gene3D G3DSA:3.30.9.10 179 322 3.5E-25 T 09-03-2017 TK78_RS32775 8bf8643db050529b5c42d1e1beb7c20d 404 Pfam PF00890 FAD binding domain 19 52 1.0E-6 T 09-03-2017 IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 TK78_RS32775 8bf8643db050529b5c42d1e1beb7c20d 404 SUPERFAMILY SSF51905 275 364 1.01E-39 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS32775 8bf8643db050529b5c42d1e1beb7c20d 404 SUPERFAMILY SSF51905 18 186 1.01E-39 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS32775 8bf8643db050529b5c42d1e1beb7c20d 404 Gene3D G3DSA:3.50.50.60 18 172 2.3E-25 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS05490 9a59141e6eb461a3e9c2ca30fa53f486 312 Pfam PF01507 Phosphoadenosine phosphosulfate reductase family 42 266 6.4E-50 T 09-03-2017 IPR002500 Phosphoadenosine phosphosulphate reductase GO:0003824|GO:0008152 Reactome: R-HSA-196843 TK78_RS05490 9a59141e6eb461a3e9c2ca30fa53f486 312 PIRSF PIRSF002936 12 312 1.4E-137 T 09-03-2017 IPR011784 Sulphate adenylyltransferase, small subunit GO:0004781|GO:0019419 KEGG: 00230+2.7.7.4|KEGG: 00261+2.7.7.4|KEGG: 00450+2.7.7.4|KEGG: 00920+2.7.7.4|MetaCyc: PWY-5278|MetaCyc: PWY-5340|MetaCyc: PWY-6683|MetaCyc: PWY-6932 TK78_RS05490 9a59141e6eb461a3e9c2ca30fa53f486 312 SUPERFAMILY SSF52402 17 220 1.09E-64 T 09-03-2017 TK78_RS05490 9a59141e6eb461a3e9c2ca30fa53f486 312 TIGRFAM TIGR02039 CysD: sulfate adenylyltransferase, small subunit 21 312 1.0E-137 T 09-03-2017 IPR011784 Sulphate adenylyltransferase, small subunit GO:0004781|GO:0019419 KEGG: 00230+2.7.7.4|KEGG: 00261+2.7.7.4|KEGG: 00450+2.7.7.4|KEGG: 00920+2.7.7.4|MetaCyc: PWY-5278|MetaCyc: PWY-5340|MetaCyc: PWY-6683|MetaCyc: PWY-6932 TK78_RS05490 9a59141e6eb461a3e9c2ca30fa53f486 312 Gene3D G3DSA:3.40.50.620 9 220 9.7E-55 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS05490 9a59141e6eb461a3e9c2ca30fa53f486 312 Gene3D G3DSA:3.40.50.620 253 261 9.7E-55 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS10415 f07ed684cfd0947e37beee7889c1d866 436 Pfam PF13535 ATP-grasp domain 155 310 2.2E-11 T 09-03-2017 TK78_RS10415 f07ed684cfd0947e37beee7889c1d866 436 Gene3D G3DSA:3.30.470.20 113 341 3.0E-28 T 09-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 TK78_RS10415 f07ed684cfd0947e37beee7889c1d866 436 SUPERFAMILY SSF56059 113 341 6.54E-33 T 09-03-2017 TK78_RS21215 a0134ca036aab3f55175df2e41f8a9f9 448 Pfam PF01757 Acyltransferase family 18 347 5.3E-17 T 09-03-2017 IPR002656 Acyltransferase 3 GO:0016747 TK78_RS14875 448c3ca408bba3d86fddcb12c352233a 326 Gene3D G3DSA:1.10.3720.10 30 310 4.5E-61 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS14875 448c3ca408bba3d86fddcb12c352233a 326 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 114 319 4.9E-18 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS14875 448c3ca408bba3d86fddcb12c352233a 326 SUPERFAMILY SSF161098 82 309 3.4E-62 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS11280 0f49aee910221cf8d610dd4900c8e9af 373 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 69 364 1.9E-66 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS11280 0f49aee910221cf8d610dd4900c8e9af 373 SUPERFAMILY SSF53686 6 368 4.32E-81 T 09-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme TK78_RS11280 0f49aee910221cf8d610dd4900c8e9af 373 ProSitePatterns PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 90 103 - T 09-03-2017 IPR000634 Serine/threonine dehydratase, pyridoxal-phosphate-binding site GO:0006520|GO:0030170 TK78_RS11280 0f49aee910221cf8d610dd4900c8e9af 373 Gene3D G3DSA:3.40.50.1100 134 369 3.5E-54 T 09-03-2017 TK78_RS09900 08fa1422713ed7391e13e8485a0a0076 379 Gene3D G3DSA:3.90.1300.10 273 375 1.5E-20 T 09-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 TK78_RS09900 08fa1422713ed7391e13e8485a0a0076 379 Gene3D G3DSA:3.90.1300.10 5 242 4.3E-50 T 09-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 TK78_RS09900 08fa1422713ed7391e13e8485a0a0076 379 Pfam PF01425 Amidase 293 356 2.6E-8 T 09-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 TK78_RS09900 08fa1422713ed7391e13e8485a0a0076 379 Pfam PF01425 Amidase 62 245 5.8E-35 T 09-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 TK78_RS09900 08fa1422713ed7391e13e8485a0a0076 379 SUPERFAMILY SSF75304 6 367 2.09E-74 T 09-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 TK78_RS17900 a9035f5b60df9ac4733210cdb5fdd673 1203 Pfam PF13191 AAA ATPase domain 5 229 1.6E-22 T 09-03-2017 TK78_RS17900 a9035f5b60df9ac4733210cdb5fdd673 1203 SUPERFAMILY SSF52540 195 311 5.92E-10 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17900 a9035f5b60df9ac4733210cdb5fdd673 1203 SUPERFAMILY SSF52540 5 92 5.92E-10 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17900 a9035f5b60df9ac4733210cdb5fdd673 1203 Gene3D G3DSA:3.40.50.300 7 62 1.8E-5 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17900 a9035f5b60df9ac4733210cdb5fdd673 1203 Gene3D G3DSA:3.40.50.300 171 237 1.8E-5 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17900 a9035f5b60df9ac4733210cdb5fdd673 1203 Gene3D G3DSA:1.25.40.10 444 532 1.6E-4 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS17900 a9035f5b60df9ac4733210cdb5fdd673 1203 SMART SM00382 26 384 2.7E-4 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS30035 90194e84283210248dd1c83d5d889222 241 SUPERFAMILY SSF53098 4 203 1.67E-41 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS30035 90194e84283210248dd1c83d5d889222 241 Gene3D G3DSA:3.30.420.10 3 188 1.7E-39 T 09-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 TK78_RS30035 90194e84283210248dd1c83d5d889222 241 SMART SM00479 8 189 9.6E-23 T 09-03-2017 IPR013520 Exonuclease, RNase T/DNA polymerase III TK78_RS30035 90194e84283210248dd1c83d5d889222 241 Pfam PF00929 Exonuclease 11 179 5.4E-15 T 09-03-2017 IPR013520 Exonuclease, RNase T/DNA polymerase III TK78_RS28215 b4fb49736418aae456aa09e42d715225 244 Pfam PF02535 ZIP Zinc transporter 94 237 2.1E-12 T 09-03-2017 IPR003689 Zinc/iron permease GO:0016020|GO:0030001|GO:0046873|GO:0055085 TK78_RS17315 a3249cd6380422ec0b147001ee8c43a8 110 TIGRFAM TIGR01068 thioredoxin: thioredoxin 9 104 2.3E-36 T 09-03-2017 IPR005746 Thioredoxin GO:0006662|GO:0015035|GO:0045454 TK78_RS17315 a3249cd6380422ec0b147001ee8c43a8 110 Pfam PF00085 Thioredoxin 6 104 5.1E-32 T 09-03-2017 IPR013766 Thioredoxin domain GO:0045454 TK78_RS17315 a3249cd6380422ec0b147001ee8c43a8 110 SUPERFAMILY SSF52833 4 106 2.06E-37 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS17315 a3249cd6380422ec0b147001ee8c43a8 110 PIRSF PIRSF000077 3 108 6.8E-42 T 09-03-2017 IPR005746 Thioredoxin GO:0006662|GO:0015035|GO:0045454 TK78_RS17315 a3249cd6380422ec0b147001ee8c43a8 110 ProSitePatterns PS00194 Thioredoxin family active site. 25 43 - T 09-03-2017 IPR017937 Thioredoxin, conserved site GO:0045454 TK78_RS17315 a3249cd6380422ec0b147001ee8c43a8 110 PRINTS PR00421 Thioredoxin family signature 72 83 1.1E-7 T 09-03-2017 TK78_RS17315 a3249cd6380422ec0b147001ee8c43a8 110 PRINTS PR00421 Thioredoxin family signature 24 32 1.1E-7 T 09-03-2017 TK78_RS17315 a3249cd6380422ec0b147001ee8c43a8 110 PRINTS PR00421 Thioredoxin family signature 32 41 1.1E-7 T 09-03-2017 TK78_RS17315 a3249cd6380422ec0b147001ee8c43a8 110 Gene3D G3DSA:3.40.30.10 4 105 1.7E-36 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS18110 621de2adabe52fbdf36765c587861480 408 SUPERFAMILY SSF111321 78 382 8.37E-42 T 09-03-2017 IPR002791 Domain of unknown function DUF89 TK78_RS18110 621de2adabe52fbdf36765c587861480 408 Pfam PF01937 Protein of unknown function DUF89 41 383 1.4E-76 T 09-03-2017 IPR002791 Domain of unknown function DUF89 TK78_RS02380 045dc658886d6d4db1f60734681b5e97 127 Pfam PF01638 HxlR-like helix-turn-helix 29 116 3.1E-28 T 09-03-2017 IPR002577 Helix-turn-helix, HxlR type TK78_RS02380 045dc658886d6d4db1f60734681b5e97 127 SUPERFAMILY SSF46785 23 124 2.06E-30 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS02380 045dc658886d6d4db1f60734681b5e97 127 Gene3D G3DSA:1.10.10.10 5 126 6.7E-40 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS15860 c4ca685aa22943c454a0d99e55036bb4 475 Gene3D G3DSA:2.130.10.130 39 379 1.7E-41 T 09-03-2017 TK78_RS15860 c4ca685aa22943c454a0d99e55036bb4 475 Pfam PF01839 FG-GAP repeat 405 438 2.7E-10 T 09-03-2017 IPR013517 FG-GAP repeat Reactome: R-HSA-216083 TK78_RS15860 c4ca685aa22943c454a0d99e55036bb4 475 Pfam PF01839 FG-GAP repeat 104 142 4.4E-9 T 09-03-2017 IPR013517 FG-GAP repeat Reactome: R-HSA-216083 TK78_RS15860 c4ca685aa22943c454a0d99e55036bb4 475 SUPERFAMILY SSF69318 35 429 9.81E-58 T 09-03-2017 TK78_RS15860 c4ca685aa22943c454a0d99e55036bb4 475 Pfam PF13517 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella 269 354 1.2E-6 T 09-03-2017 TK78_RS15860 c4ca685aa22943c454a0d99e55036bb4 475 SMART SM00191 258 318 24.0 T 09-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 TK78_RS15860 c4ca685aa22943c454a0d99e55036bb4 475 SMART SM00191 331 391 8.4E-5 T 09-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 TK78_RS15860 c4ca685aa22943c454a0d99e55036bb4 475 SMART SM00191 401 454 9.8E-10 T 09-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 TK78_RS15860 c4ca685aa22943c454a0d99e55036bb4 475 SMART SM00191 28 88 1.1 T 09-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 TK78_RS15860 c4ca685aa22943c454a0d99e55036bb4 475 SMART SM00191 100 157 8.5E-6 T 09-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 TK78_RS16815 4a75a02d398d0bdfdfb2fdef9a1dfc78 273 SUPERFAMILY SSF56112 32 219 3.06E-12 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS16815 4a75a02d398d0bdfdfb2fdef9a1dfc78 273 Gene3D G3DSA:3.90.1200.10 133 205 7.2E-6 T 09-03-2017 TK78_RS30675 f21456473d305ad5ffc9ed9e284774d8 128 SUPERFAMILY SSF52038 4 70 7.06E-17 T 09-03-2017 IPR000468 Barstar (barnase inhibitor) TK78_RS30675 f21456473d305ad5ffc9ed9e284774d8 128 SUPERFAMILY SSF52038 107 121 7.06E-17 T 09-03-2017 IPR000468 Barstar (barnase inhibitor) TK78_RS30675 f21456473d305ad5ffc9ed9e284774d8 128 Gene3D G3DSA:3.30.370.10 4 79 2.1E-17 T 09-03-2017 IPR000468 Barstar (barnase inhibitor) TK78_RS30675 f21456473d305ad5ffc9ed9e284774d8 128 Pfam PF01337 Barstar (barnase inhibitor) 7 72 1.3E-15 T 09-03-2017 IPR000468 Barstar (barnase inhibitor) TK78_RS11770 fe2cc09b115a58fb01cab4af3eff9967 230 Pfam PF03006 Haemolysin-III related 22 219 1.6E-41 T 09-03-2017 IPR004254 AdipoR/Haemolysin-III-related GO:0016021 TK78_RS18820 eb589b3904ee49e209830a7e689b3779 272 SUPERFAMILY SSF46894 126 221 3.21E-30 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS18820 eb589b3904ee49e209830a7e689b3779 272 Pfam PF00486 Transcriptional regulatory protein, C terminal 146 219 1.3E-28 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS18820 eb589b3904ee49e209830a7e689b3779 272 SMART SM00862 145 219 2.2E-30 T 09-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TK78_RS18820 eb589b3904ee49e209830a7e689b3779 272 Gene3D G3DSA:1.10.10.10 123 222 1.5E-36 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS28335 6a7fc671d17cc5b6c78f2b94c8db8f52 268 Pfam PF02104 SURF1 family 20 227 1.8E-31 T 09-03-2017 IPR002994 Surfeit locus 1/Shy1 GO:0016020 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS21845 222534752b9987388f6f620f3bba430c 229 Pfam PF13489 Methyltransferase domain 31 140 8.6E-17 T 09-03-2017 TK78_RS21845 222534752b9987388f6f620f3bba430c 229 Gene3D G3DSA:3.40.50.150 33 139 7.2E-25 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS21845 222534752b9987388f6f620f3bba430c 229 SUPERFAMILY SSF53335 13 151 1.27E-29 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS11390 813321c7134412d187c1b1e6feea996d 231 Pfam PF09922 Cell wall-active antibiotics response 4TMS YvqF 117 189 5.6E-9 T 09-03-2017 IPR024425 Cell wall-active antibiotics response 4TMS YvqF TK78_RS11390 813321c7134412d187c1b1e6feea996d 231 Pfam PF08044 Domain of unknown function (DUF1707) 27 79 4.8E-23 T 09-03-2017 IPR012551 Protein of unknown function DUF1707 TK78_RS21520 d978c43d043111e125e268a91da67ee8 196 SUPERFAMILY SSF52499 15 147 3.79E-43 T 09-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 TK78_RS21520 d978c43d043111e125e268a91da67ee8 196 Pfam PF00857 Isochorismatase family 17 147 7.6E-37 T 09-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 TK78_RS21520 d978c43d043111e125e268a91da67ee8 196 Gene3D G3DSA:3.40.50.850 16 148 2.6E-43 T 09-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 TK78_RS02815 b751d6743453e55f91e2819eb6ede910 883 Gene3D G3DSA:1.25.40.10 473 513 4.3E-14 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS02815 b751d6743453e55f91e2819eb6ede910 883 Gene3D G3DSA:1.25.40.10 601 782 4.3E-14 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS02815 b751d6743453e55f91e2819eb6ede910 883 Gene3D G3DSA:1.25.40.10 404 438 4.3E-14 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS02815 b751d6743453e55f91e2819eb6ede910 883 SUPERFAMILY SSF52540 5 253 1.09E-7 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS02815 b751d6743453e55f91e2819eb6ede910 883 Pfam PF13191 AAA ATPase domain 6 177 2.7E-18 T 09-03-2017 TK78_RS02815 b751d6743453e55f91e2819eb6ede910 883 SUPERFAMILY SSF48452 606 702 7.59E-9 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS13545 8780771e5745e42d273bddad3e26f194 420 SUPERFAMILY SSF89392 146 298 7.06E-13 T 09-03-2017 IPR029046 Lipoprotein localisation LolA/LolB/LppX TK78_RS13545 8780771e5745e42d273bddad3e26f194 420 Gene3D G3DSA:2.50.20.10 147 298 2.1E-14 T 09-03-2017 TK78_RS29155 baa9de8e2cd08723718c367ca8a69d3f 169 Gene3D G3DSA:3.40.50.300 3 166 3.4E-64 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29155 baa9de8e2cd08723718c367ca8a69d3f 169 Pfam PF01202 Shikimate kinase 14 164 1.6E-7 T 09-03-2017 IPR031322 Shikimate kinase/gluconokinase KEGG: 00400+2.7.1.71|MetaCyc: PWY-6163 TK78_RS29155 baa9de8e2cd08723718c367ca8a69d3f 169 SUPERFAMILY SSF52540 1 166 1.98E-23 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29155 baa9de8e2cd08723718c367ca8a69d3f 169 TIGRFAM TIGR01313 therm_gnt_kin: carbohydrate kinase, thermoresistant glucokinase family 7 162 5.9E-56 T 09-03-2017 IPR006001 Carbohydrate kinase, thermoresistant glucokinase GO:0005975|GO:0016301 KEGG: 00030+2.7.1.12|MetaCyc: PWY-5530 TK78_RS21755 e1b140b754453687b7fa41e0be1ddd12 122 Gene3D G3DSA:3.30.750.24 14 121 1.4E-35 T 09-03-2017 IPR002645 STAS domain TK78_RS21755 e1b140b754453687b7fa41e0be1ddd12 122 TIGRFAM TIGR00377 ant_ant_sig: anti-anti-sigma factor 14 118 4.7E-23 T 09-03-2017 IPR003658 Anti-sigma factor antagonist GO:0006355|GO:0045152 TK78_RS21755 e1b140b754453687b7fa41e0be1ddd12 122 SUPERFAMILY SSF52091 14 121 7.65E-27 T 09-03-2017 IPR002645 STAS domain TK78_RS21755 e1b140b754453687b7fa41e0be1ddd12 122 Pfam PF13466 STAS domain 31 105 1.4E-16 T 09-03-2017 IPR002645 STAS domain TK78_RS15025 bb1121acda9c977b51a049eabeb3d0a7 832 Pfam PF02687 FtsX-like permease family 257 370 1.6E-15 T 09-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 TK78_RS13455 ffe3525e05129bd398674717ff0dde63 292 SUPERFAMILY SSF51735 3 271 3.36E-56 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS13455 ffe3525e05129bd398674717ff0dde63 292 Gene3D G3DSA:3.40.50.720 1 218 2.1E-39 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS13455 ffe3525e05129bd398674717ff0dde63 292 Pfam PF05368 NmrA-like family 3 221 2.0E-20 T 09-03-2017 IPR008030 NmrA-like domain Reactome: R-HSA-70635 TK78_RS18665 a3809f47b20f26e36686b90a0bc969f7 380 Pfam PF05235 CHAD domain 97 331 1.4E-18 T 09-03-2017 IPR007899 CHAD domain TK78_RS18665 a3809f47b20f26e36686b90a0bc969f7 380 SMART SM00880 73 365 2.2E-5 T 09-03-2017 IPR007899 CHAD domain TK78_RS02835 84cf8b00f5232618db6371c6a167b893 210 Gene3D G3DSA:3.40.50.10420 38 206 3.3E-49 T 09-03-2017 IPR024185 5-formyltetrahydrofolate cyclo-ligase-like domain TK78_RS02835 84cf8b00f5232618db6371c6a167b893 210 SUPERFAMILY SSF100950 37 206 5.44E-36 T 09-03-2017 TK78_RS02835 84cf8b00f5232618db6371c6a167b893 210 Pfam PF02589 Uncharacterised ACR, YkgG family COG1556 91 206 7.2E-18 T 09-03-2017 IPR003741 LUD domain TK78_RS14075 f322928eb044314dbecc7325b9da5c2e 251 Pfam PF13580 SIS domain 9 146 1.6E-38 T 09-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 TK78_RS14075 f322928eb044314dbecc7325b9da5c2e 251 SUPERFAMILY SSF53697 8 206 3.03E-21 T 09-03-2017 TK78_RS14075 f322928eb044314dbecc7325b9da5c2e 251 Gene3D G3DSA:3.40.50.10490 7 245 7.4E-68 T 09-03-2017 TK78_RS33930 949710e9f23e4225c51de2f51d00d7ab 165 Pfam PF13673 Acetyltransferase (GNAT) domain 65 146 1.4E-10 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS33930 949710e9f23e4225c51de2f51d00d7ab 165 SUPERFAMILY SSF55729 18 151 1.66E-21 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS33930 949710e9f23e4225c51de2f51d00d7ab 165 Gene3D G3DSA:3.40.630.30 18 150 3.5E-20 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS06905 5b216676866037c0459f29f881d74af9 152 Pfam PF11292 Protein of unknown function (DUF3093) 8 146 6.4E-45 T 09-03-2017 IPR021443 Protein of unknown function DUF3093 TK78_RS26215 36ed2431283cac570cd198bbac72ba06 290 Pfam PF01061 ABC-2 type transporter 41 255 5.5E-33 T 09-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 TK78_RS26215 36ed2431283cac570cd198bbac72ba06 290 PIRSF PIRSF006648 17 290 1.5E-83 T 09-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 TK78_RS34060 0976a83c636a35780888e9b9efc60a96 505 Gene3D G3DSA:3.50.50.60 197 294 4.5E-27 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS34060 0976a83c636a35780888e9b9efc60a96 505 Gene3D G3DSA:3.50.50.60 1 64 4.5E-27 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS34060 0976a83c636a35780888e9b9efc60a96 505 Pfam PF01266 FAD dependent oxidoreductase 1 302 5.0E-10 T 09-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 TK78_RS34060 0976a83c636a35780888e9b9efc60a96 505 SUPERFAMILY SSF51905 467 488 4.86E-33 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS34060 0976a83c636a35780888e9b9efc60a96 505 SUPERFAMILY SSF51905 1 310 4.86E-33 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS34435 fee6765d8dd69466778cac734ff34bff 183 Gene3D G3DSA:1.10.357.10 2 178 1.1E-27 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS34435 fee6765d8dd69466778cac734ff34bff 183 SUPERFAMILY SSF46689 2 62 1.28E-15 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS34435 fee6765d8dd69466778cac734ff34bff 183 Pfam PF00440 Bacterial regulatory proteins, tetR family 2 42 3.3E-12 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS05325 daff298b5c13de0631cbde7e63fca01e 580 Pfam PF13672 Protein phosphatase 2C 311 559 3.8E-17 T 09-03-2017 TK78_RS06440 6d21a78e2414618df658851656e3ef3e 503 SUPERFAMILY SSF53335 283 456 2.24E-21 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS06440 6d21a78e2414618df658851656e3ef3e 503 TIGRFAM TIGR04074 bacter_Hen1: 3' terminal RNA ribose 2'-O-methyltransferase Hen1 9 478 2.1E-204 T 09-03-2017 IPR024026 3'-RNA ribose 2'-O-methyltransferase, Hen1, bacterial TK78_RS06440 6d21a78e2414618df658851656e3ef3e 503 Pfam PF08242 Methyltransferase domain 303 403 1.0E-11 T 09-03-2017 IPR013217 Methyltransferase type 12 TK78_RS06440 6d21a78e2414618df658851656e3ef3e 503 Pfam PF12623 RNA repair, ligase-Pnkp-associating, region of Hen1 2 249 2.4E-111 T 09-03-2017 IPR024740 Hen1, N-terminal TK78_RS06440 6d21a78e2414618df658851656e3ef3e 503 Gene3D G3DSA:3.40.50.150 284 458 6.9E-22 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS02745 1cb2b5231faf82fe9e2c4a0c632440e3 117 Pfam PF13340 Putative transposase of IS4/5 family (DUF4096) 12 68 1.0E-13 T 09-03-2017 IPR025161 Putative transposase IS4/IS5 family TK78_RS23620 2212a96262fc796c2f47cc8a9607c9b2 191 Pfam PF13586 Transposase DDE domain 94 188 2.2E-22 T 09-03-2017 IPR025668 Transposase DDE domain TK78_RS00940 a572bda4b359599896e68b0450afd13e 216 TIGRFAM TIGR01167 LPXTG_anchor: LPXTG cell wall anchor domain 178 212 1.2E-4 T 09-03-2017 IPR019931 LPXTG cell wall anchor domain TK78_RS31170 8742e5bc36039f0b624bc9a01c72bb87 344 Pfam PF00487 Fatty acid desaturase 66 297 9.4E-31 T 09-03-2017 IPR005804 Fatty acid desaturase domain GO:0006629 TK78_RS33985 d2653b58d3dc1567f5fa1c09f0a8ff4d 470 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 261 272 - T 09-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 TK78_RS33985 d2653b58d3dc1567f5fa1c09f0a8ff4d 470 Pfam PF00171 Aldehyde dehydrogenase family 3 462 3.0E-142 T 09-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 TK78_RS33985 d2653b58d3dc1567f5fa1c09f0a8ff4d 470 Gene3D G3DSA:3.40.309.10 248 438 3.0E-64 T 09-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 TK78_RS33985 d2653b58d3dc1567f5fa1c09f0a8ff4d 470 SUPERFAMILY SSF53720 3 466 3.93E-146 T 09-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 TK78_RS33985 d2653b58d3dc1567f5fa1c09f0a8ff4d 470 Gene3D G3DSA:3.40.605.10 3 247 2.7E-74 T 09-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 TK78_RS10505 d7d0eb150e473c7e8ffba1b198c8d952 998 Hamap MF_01600 UPF0182 protein . 17 887 17.951 T 09-03-2017 IPR005372 Uncharacterised protein family UPF0182 GO:0016021 TK78_RS10505 d7d0eb150e473c7e8ffba1b198c8d952 998 Pfam PF03699 Uncharacterised protein family (UPF0182) 26 807 2.2E-277 T 09-03-2017 IPR005372 Uncharacterised protein family UPF0182 GO:0016021 TK78_RS01815 39738c8fea1d4d76185a056e2598d2b9 346 Pfam PF02653 Branched-chain amino acid transport system / permease component 60 323 7.7E-43 T 09-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 TK78_RS05980 d97627d381ccfb096fd919f4561111f3 133 Gene3D G3DSA:3.40.50.1010 65 120 1.2E-4 T 09-03-2017 IPR029060 PIN domain-like TK78_RS19150 14fcbf8d6b8fb96cb43a4e80630b8529 256 Pfam PF13649 Methyltransferase domain 89 155 2.0E-8 T 09-03-2017 TK78_RS19150 14fcbf8d6b8fb96cb43a4e80630b8529 256 SUPERFAMILY SSF53335 60 179 1.88E-19 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS19150 14fcbf8d6b8fb96cb43a4e80630b8529 256 Gene3D G3DSA:3.40.50.150 65 179 7.3E-14 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS29755 faeb238ca675740c2e6bfc6ea474a516 201 Gene3D G3DSA:1.10.3630.10 21 185 3.9E-5 T 09-03-2017 TK78_RS29755 faeb238ca675740c2e6bfc6ea474a516 201 Pfam PF05719 Golgi phosphoprotein 3 (GPP34) 5 180 7.8E-19 T 09-03-2017 IPR008628 Golgi phosphoprotein 3 GO:0048193|GO:0070273 TK78_RS00045 c5a7ee62e072316c1db666010896fd87 188 TIGRFAM TIGR04402 mob_CxxC_CxxC: mobilome CxxCx(11)CxxC protein 7 187 4.1E-31 T 09-03-2017 IPR030914 Mobilome CxxCx(11)CxxC protein TK78_RS07745 8b3b5bf54d6e503341c4857d7a03d896 1062 Gene3D G3DSA:3.40.50.300 615 829 2.2E-26 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07745 8b3b5bf54d6e503341c4857d7a03d896 1062 SUPERFAMILY SSF52540 614 848 3.47E-24 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS07745 8b3b5bf54d6e503341c4857d7a03d896 1062 Pfam PF13614 AAA domain 616 764 3.7E-11 T 09-03-2017 IPR025669 AAA domain TK78_RS00535 a158bf50d6fb49005d4f725fb547a788 187 SUPERFAMILY SSF158682 52 186 4.71E-25 T 09-03-2017 IPR029024 TerB-like TK78_RS00535 a158bf50d6fb49005d4f725fb547a788 187 Gene3D G3DSA:1.10.3680.10 55 185 7.9E-24 T 09-03-2017 IPR029024 TerB-like TK78_RS00535 a158bf50d6fb49005d4f725fb547a788 187 Pfam PF05099 Tellurite resistance protein TerB 50 185 2.1E-28 T 09-03-2017 IPR007791 Co-chaperone DjlA, N-terminal TK78_RS04670 6726f40f4c1e8611e8f41d2a5b2d9adc 333 Gene3D G3DSA:3.20.20.30 1 332 2.0E-72 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS04670 6726f40f4c1e8611e8f41d2a5b2d9adc 333 SUPERFAMILY SSF51679 1 329 9.55E-61 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS04670 6726f40f4c1e8611e8f41d2a5b2d9adc 333 Pfam PF00296 Luciferase-like monooxygenase 7 306 3.3E-56 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS04670 6726f40f4c1e8611e8f41d2a5b2d9adc 333 TIGRFAM TIGR03842 F420_CPS_4043: F420-dependent oxidoreductase, CPS_4043 family 2 331 7.0E-181 T 09-03-2017 IPR022315 F420-dependent oxidoreductase-predicted, CPS4043 TK78_RS09905 63a44433384e08c6be1822ffd8bda9d1 282 SUPERFAMILY SSF81995 4 74 7.06E-7 T 09-03-2017 TK78_RS16065 214563b6522fe4646446415c73012ff5 282 SUPERFAMILY SSF56024 105 202 1.51E-5 T 09-03-2017 TK78_RS16065 214563b6522fe4646446415c73012ff5 282 SMART SM00421 215 272 4.4E-4 T 09-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TK78_RS16065 214563b6522fe4646446415c73012ff5 282 Gene3D G3DSA:1.10.10.10 217 277 7.2E-10 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS16065 214563b6522fe4646446415c73012ff5 282 SUPERFAMILY SSF46894 210 279 1.39E-9 T 09-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TK78_RS16065 214563b6522fe4646446415c73012ff5 282 Gene3D G3DSA:3.30.870.10 73 203 1.2E-4 T 09-03-2017 TK78_RS17015 0710781213ca7eee8d12f2d477d43473 239 Pfam PF12679 ABC-2 family transporter protein 37 169 2.8E-10 T 09-03-2017 IPR032688 ABC-2 family transporter protein GO:0006810 TK78_RS21005 c1ded26b76f58009ef145decb298256b 312 Pfam PF12697 Alpha/beta hydrolase family 41 287 3.6E-21 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS21005 c1ded26b76f58009ef145decb298256b 312 Gene3D G3DSA:3.40.50.1820 22 295 1.2E-54 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS21005 c1ded26b76f58009ef145decb298256b 312 PRINTS PR00111 Alpha/beta hydrolase fold signature 239 253 1.9E-7 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS21005 c1ded26b76f58009ef145decb298256b 312 PRINTS PR00111 Alpha/beta hydrolase fold signature 64 79 1.9E-7 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS21005 c1ded26b76f58009ef145decb298256b 312 PRINTS PR00111 Alpha/beta hydrolase fold signature 111 124 1.9E-7 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS21005 c1ded26b76f58009ef145decb298256b 312 SUPERFAMILY SSF53474 22 293 5.1E-52 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS05075 a71c212f67a7258afbcaa699e38d908c 209 Pfam PF00583 Acetyltransferase (GNAT) family 64 137 1.4E-11 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS05075 a71c212f67a7258afbcaa699e38d908c 209 Gene3D G3DSA:3.40.630.30 1 175 7.2E-24 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS05075 a71c212f67a7258afbcaa699e38d908c 209 SUPERFAMILY SSF55729 1 145 2.23E-24 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS13395 0d4cf4d42d82568719e2734e46e6147c 121 Pfam PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 8 97 1.1E-27 T 09-03-2017 IPR001133 NADH-ubiquinone oxidoreductase chain 4L/K GO:0016651|GO:0042773|GO:0055114 TK78_RS13395 0d4cf4d42d82568719e2734e46e6147c 121 Hamap MF_01456 NAD(P)H-quinone oxidoreductase subunit 4L, chloroplastic [ndhE]. 1 102 18.996 T 09-03-2017 IPR001133 NADH-ubiquinone oxidoreductase chain 4L/K GO:0016651|GO:0042773|GO:0055114 TK78_RS20045 65a00cbfbfe6789ab049518b60983e78 282 Pfam PF14062 Domain of unknown function (DUF4253) 172 282 1.1E-38 T 09-03-2017 IPR025349 Domain of unknown function DUF4253 TK78_RS34320 7f72b1dce60b55da1a86643aee80f9d9 167 Pfam PF13302 Acetyltransferase (GNAT) domain 5 140 1.1E-15 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS34320 7f72b1dce60b55da1a86643aee80f9d9 167 Gene3D G3DSA:3.40.630.30 4 140 1.7E-22 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS34320 7f72b1dce60b55da1a86643aee80f9d9 167 SUPERFAMILY SSF55729 4 141 4.29E-22 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS15620 1769095620528bc861b33fa53356751e 526 Pfam PF07905 Purine catabolism regulatory protein-like family 5 121 1.1E-20 T 09-03-2017 IPR012914 Purine catabolism PurC-like domain TK78_RS15620 1769095620528bc861b33fa53356751e 526 Pfam PF13556 PucR C-terminal helix-turn-helix domain 467 524 1.0E-20 T 09-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain TK78_RS30155 ece987a785a32133c5767c8078c52bee 398 Gene3D G3DSA:1.20.1250.20 222 394 6.1E-16 T 09-03-2017 TK78_RS30155 ece987a785a32133c5767c8078c52bee 398 Gene3D G3DSA:1.20.1250.20 20 202 3.7E-27 T 09-03-2017 TK78_RS30155 ece987a785a32133c5767c8078c52bee 398 Pfam PF07690 Major Facilitator Superfamily 226 388 6.7E-13 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS30155 ece987a785a32133c5767c8078c52bee 398 Pfam PF07690 Major Facilitator Superfamily 29 202 1.1E-21 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS30155 ece987a785a32133c5767c8078c52bee 398 SUPERFAMILY SSF103473 14 393 7.19E-53 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS16055 2e0e4114c47292aac08c758d96c7d9df 106 Gene3D G3DSA:2.102.10.10 20 61 1.3E-4 T 09-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 TK78_RS16055 2e0e4114c47292aac08c758d96c7d9df 106 SUPERFAMILY SSF50022 6 87 4.0E-12 T 09-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 TK78_RS04600 700de728e9d1c97268d2ee7f7b456b0b 354 SUPERFAMILY SSF55681 97 350 6.96E-66 T 09-03-2017 TK78_RS04600 700de728e9d1c97268d2ee7f7b456b0b 354 Pfam PF03099 Biotin/lipoate A/B protein ligase family 157 267 2.2E-6 T 09-03-2017 IPR004143 Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain GO:0006464 TK78_RS04600 700de728e9d1c97268d2ee7f7b456b0b 354 Gene3D G3DSA:3.90.1550.10 94 350 1.8E-65 T 09-03-2017 TK78_RS10680 4e0c9ba63c5ffccc0c32e89a904e1974 75 Pfam PF11305 Protein of unknown function (DUF3107) 1 73 5.4E-30 T 09-03-2017 IPR021456 Protein of unknown function DUF3107 TK78_RS08740 34eb7cdc19f58e99a5fd302ffbd9967b 260 Hamap MF_01139 Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) [uppS]. 29 260 32.935 T 09-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TK78_RS08740 34eb7cdc19f58e99a5fd302ffbd9967b 260 SUPERFAMILY SSF64005 29 255 1.96E-63 T 09-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TK78_RS08740 34eb7cdc19f58e99a5fd302ffbd9967b 260 Gene3D G3DSA:3.40.1180.10 16 260 1.2E-73 T 09-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TK78_RS08740 34eb7cdc19f58e99a5fd302ffbd9967b 260 ProSitePatterns PS01066 Undecaprenyl pyrophosphate synthase family signature. 205 222 - T 09-03-2017 IPR018520 Di-trans-poly-cis-decaprenylcistransferase-like, conserved site GO:0016765 Reactome: R-HSA-446199|Reactome: R-HSA-4755609 TK78_RS08740 34eb7cdc19f58e99a5fd302ffbd9967b 260 TIGRFAM TIGR00055 uppS: di-trans,poly-cis-decaprenylcistransferase 30 259 2.7E-56 T 09-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TK78_RS08740 34eb7cdc19f58e99a5fd302ffbd9967b 260 Pfam PF01255 Putative undecaprenyl diphosphate synthase 37 259 8.1E-62 T 09-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TK78_RS33715 c642f1a77390582b414916dd57d1bbab 368 Gene3D G3DSA:2.60.40.10 20 105 2.5E-9 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS33715 c642f1a77390582b414916dd57d1bbab 368 SUPERFAMILY SSF81296 18 123 1.34E-19 T 09-03-2017 IPR014756 Immunoglobulin E-set TK78_RS33715 c642f1a77390582b414916dd57d1bbab 368 SUPERFAMILY SSF53474 131 363 1.2E-30 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS33715 c642f1a77390582b414916dd57d1bbab 368 Pfam PF00756 Putative esterase 148 365 1.0E-31 T 09-03-2017 IPR000801 Putative esterase Reactome: R-HSA-156590 TK78_RS33715 c642f1a77390582b414916dd57d1bbab 368 Gene3D G3DSA:3.40.50.1820 122 367 1.9E-46 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS12875 40d60ff56766afb81a5e823ccced0e87 122 Gene3D G3DSA:3.90.470.20 2 121 1.4E-38 T 09-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 TK78_RS12875 40d60ff56766afb81a5e823ccced0e87 122 Hamap MF_00101 Holo-[acyl-carrier-protein] synthase [acpS]. 3 122 22.303 T 09-03-2017 IPR002582 Holo-[acyl carrier protein] synthase GO:0000287|GO:0006633|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1 TK78_RS12875 40d60ff56766afb81a5e823ccced0e87 122 ProDom PD004282 TRANSFERASE SYNTHASE HOLO-ACYL-CARRIER-PROTEIN HOLO-ACP 4'-PHOSPHOPANTETHEINYL FATTY ACID METAL-BINDING MAGNESIUM LIPID 8 83 1.0E-9 T 09-03-2017 IPR004568 Phosphopantetheine-protein transferase domain GO:0000287|GO:0006633|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1 TK78_RS12875 40d60ff56766afb81a5e823ccced0e87 122 TIGRFAM TIGR00556 pantethn_trn: phosphopantetheine--protein transferase domain 3 120 1.8E-23 T 09-03-2017 IPR004568 Phosphopantetheine-protein transferase domain GO:0000287|GO:0006633|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1 TK78_RS12875 40d60ff56766afb81a5e823ccced0e87 122 Pfam PF01648 4'-phosphopantetheinyl transferase superfamily 4 102 1.0E-11 T 09-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 TK78_RS12875 40d60ff56766afb81a5e823ccced0e87 122 SUPERFAMILY SSF56214 2 121 8.76E-24 T 09-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 TK78_RS12875 40d60ff56766afb81a5e823ccced0e87 122 TIGRFAM TIGR00516 acpS: holo-[acyl-carrier-protein] synthase 2 121 1.3E-20 T 09-03-2017 IPR002582 Holo-[acyl carrier protein] synthase GO:0000287|GO:0006633|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1 TK78_RS02225 e3c3e7c656144517e66c3d97215269b5 319 Pfam PF03640 Secreted repeat of unknown function 139 179 2.1E-15 T 09-03-2017 IPR005297 Lipoprotein repeat TK78_RS02225 e3c3e7c656144517e66c3d97215269b5 319 Pfam PF03640 Secreted repeat of unknown function 209 250 1.4E-14 T 09-03-2017 IPR005297 Lipoprotein repeat TK78_RS02225 e3c3e7c656144517e66c3d97215269b5 319 Pfam PF03640 Secreted repeat of unknown function 268 309 1.3E-14 T 09-03-2017 IPR005297 Lipoprotein repeat TK78_RS02225 e3c3e7c656144517e66c3d97215269b5 319 Pfam PF03640 Secreted repeat of unknown function 79 120 5.1E-14 T 09-03-2017 IPR005297 Lipoprotein repeat TK78_RS27765 ed49d0a387782cda9a1cbddd6434d50a 120 Pfam PF05899 Protein of unknown function (DUF861) 45 116 8.9E-19 T 09-03-2017 IPR008579 Domain of unknown function DUF861, cupin-3 KEGG: 00230+3.5.3.26|MetaCyc: PWY-5692|MetaCyc: PWY-5698 TK78_RS27765 ed49d0a387782cda9a1cbddd6434d50a 120 Gene3D G3DSA:2.60.120.10 23 118 1.2E-24 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS27765 ed49d0a387782cda9a1cbddd6434d50a 120 SUPERFAMILY SSF51182 24 117 1.69E-13 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS34465 91b2adc96d67b0eccaf5f5d18ce0cf95 345 Pfam PF13411 MerR HTH family regulatory protein 10 77 6.6E-18 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS34465 91b2adc96d67b0eccaf5f5d18ce0cf95 345 SMART SM00422 9 78 6.1E-21 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS34465 91b2adc96d67b0eccaf5f5d18ce0cf95 345 Gene3D G3DSA:1.10.1660.10 10 128 1.0E-26 T 09-03-2017 TK78_RS34465 91b2adc96d67b0eccaf5f5d18ce0cf95 345 SUPERFAMILY SSF46955 10 120 3.11E-22 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS34465 91b2adc96d67b0eccaf5f5d18ce0cf95 345 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 21 34 3.2E-11 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS34465 91b2adc96d67b0eccaf5f5d18ce0cf95 345 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 10 21 3.2E-11 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS34465 91b2adc96d67b0eccaf5f5d18ce0cf95 345 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 45 65 3.2E-11 T 09-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TK78_RS05825 7976d1314dca37f446845dfdfffc81a6 156 SUPERFAMILY SSF52402 9 153 8.37E-20 T 09-03-2017 TK78_RS05825 7976d1314dca37f446845dfdfffc81a6 156 Gene3D G3DSA:3.40.50.620 68 154 1.0E-11 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS14045 87cec7c63029a65f689357001ebaab68 460 SUPERFAMILY SSF48452 221 436 8.54E-7 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS14045 87cec7c63029a65f689357001ebaab68 460 Gene3D G3DSA:1.25.40.10 351 419 1.6E-4 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS14045 87cec7c63029a65f689357001ebaab68 460 Gene3D G3DSA:1.25.40.10 227 258 1.6E-4 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS14045 87cec7c63029a65f689357001ebaab68 460 Gene3D G3DSA:1.25.40.10 293 294 1.6E-4 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS04460 c5c57742f53f85c652f9593d6779b617 319 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 115 310 9.3E-18 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS04460 c5c57742f53f85c652f9593d6779b617 319 SUPERFAMILY SSF161098 81 305 4.84E-59 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS04460 c5c57742f53f85c652f9593d6779b617 319 Gene3D G3DSA:1.10.3720.10 87 316 6.2E-59 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS16675 e09d64ac49cb8f2512b8d89775a238d5 311 Pfam PF10977 Protein of unknown function (DUF2797) 43 285 1.5E-29 T 09-03-2017 IPR021246 Protein of unknown function DUF2797 TK78_RS25475 8f5fda9fa0bf09aa59016301a0e47fbb 219 SUPERFAMILY SSF51182 14 217 2.22E-45 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS25475 8f5fda9fa0bf09aa59016301a0e47fbb 219 Gene3D G3DSA:2.60.120.10 159 217 3.0E-5 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS25475 8f5fda9fa0bf09aa59016301a0e47fbb 219 Gene3D G3DSA:2.60.120.10 11 134 1.4E-37 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS25475 8f5fda9fa0bf09aa59016301a0e47fbb 219 Pfam PF02678 Pirin 17 120 1.0E-26 T 09-03-2017 IPR003829 Pirin, N-terminal domain TK78_RS00580 f3220ae250ab2b7ac7e4fbb59ce6ed67 276 ProSitePatterns PS00062 Aldo/keto reductase family signature 2. 126 143 - T 09-03-2017 IPR018170 Aldo/keto reductase, conserved site GO:0016491|GO:0055114 TK78_RS00580 f3220ae250ab2b7ac7e4fbb59ce6ed67 276 PIRSF PIRSF000097 2 273 1.4E-89 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS00580 f3220ae250ab2b7ac7e4fbb59ce6ed67 276 Gene3D G3DSA:3.20.20.100 6 273 1.1E-102 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS00580 f3220ae250ab2b7ac7e4fbb59ce6ed67 276 Pfam PF00248 Aldo/keto reductase family 18 262 8.4E-46 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS00580 f3220ae250ab2b7ac7e4fbb59ce6ed67 276 SUPERFAMILY SSF51430 7 269 1.14E-91 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS00580 f3220ae250ab2b7ac7e4fbb59ce6ed67 276 PRINTS PR00069 Aldo-keto reductase signature 37 61 9.4E-51 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS00580 f3220ae250ab2b7ac7e4fbb59ce6ed67 276 PRINTS PR00069 Aldo-keto reductase signature 93 111 9.4E-51 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS00580 f3220ae250ab2b7ac7e4fbb59ce6ed67 276 PRINTS PR00069 Aldo-keto reductase signature 197 221 9.4E-51 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS00580 f3220ae250ab2b7ac7e4fbb59ce6ed67 276 PRINTS PR00069 Aldo-keto reductase signature 126 143 9.4E-51 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS00580 f3220ae250ab2b7ac7e4fbb59ce6ed67 276 PRINTS PR00069 Aldo-keto reductase signature 160 189 9.4E-51 T 09-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 TK78_RS00580 f3220ae250ab2b7ac7e4fbb59ce6ed67 276 ProSitePatterns PS00798 Aldo/keto reductase family signature 1. 41 58 - T 09-03-2017 IPR018170 Aldo/keto reductase, conserved site GO:0016491|GO:0055114 TK78_RS02665 56f5cad4d60b5051399221195bc75118 166 SMART SM00347 43 144 2.0E-5 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS02665 56f5cad4d60b5051399221195bc75118 166 Pfam PF12802 MarR family 50 107 4.8E-12 T 09-03-2017 TK78_RS02665 56f5cad4d60b5051399221195bc75118 166 SUPERFAMILY SSF46785 22 158 6.5E-23 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS02665 56f5cad4d60b5051399221195bc75118 166 Gene3D G3DSA:1.10.10.10 17 159 5.7E-27 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS00295 26902d60c6ed6b5da96b46518cbd5025 118 Pfam PF08818 Domain of unknown function (DU1801) 19 110 2.0E-9 T 09-03-2017 IPR014922 Domain of unknown function DUF1801 TK78_RS00295 26902d60c6ed6b5da96b46518cbd5025 118 SUPERFAMILY SSF159888 6 111 6.54E-24 T 09-03-2017 TK78_RS07790 6f37ce67ef3d9dd395c1752116974d96 372 Pfam PF02625 XdhC and CoxI family 13 78 4.2E-22 T 09-03-2017 IPR003777 XdhC- CoxI TK78_RS07790 6f37ce67ef3d9dd395c1752116974d96 372 Pfam PF02625 XdhC and CoxI family 118 182 5.4E-13 T 09-03-2017 IPR003777 XdhC- CoxI TK78_RS07790 6f37ce67ef3d9dd395c1752116974d96 372 Pfam PF13478 XdhC Rossmann domain 205 347 5.7E-42 T 09-03-2017 IPR027051 XdhC Rossmann domain TK78_RS33990 85a2e5855936a56bdc6962c70ee76f00 319 Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 32 316 1.8E-9 T 09-03-2017 IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0008152|GO:0016616|GO:0051287|GO:0055114 TK78_RS33990 85a2e5855936a56bdc6962c70ee76f00 319 SUPERFAMILY SSF51735 109 288 5.58E-51 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS33990 85a2e5855936a56bdc6962c70ee76f00 319 Gene3D G3DSA:3.40.50.720 21 114 1.3E-18 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS33990 85a2e5855936a56bdc6962c70ee76f00 319 SUPERFAMILY SSF52283 20 127 3.61E-19 T 09-03-2017 TK78_RS33990 85a2e5855936a56bdc6962c70ee76f00 319 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 114 288 2.1E-53 T 09-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 TK78_RS33990 85a2e5855936a56bdc6962c70ee76f00 319 Gene3D G3DSA:3.40.50.720 115 289 8.5E-57 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS24510 9261ee2b29fc3513708fdd5740ee3518 552 Gene3D G3DSA:3.90.550.10 12 206 4.4E-42 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS24510 9261ee2b29fc3513708fdd5740ee3518 552 SUPERFAMILY SSF53448 12 222 4.64E-44 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS24510 9261ee2b29fc3513708fdd5740ee3518 552 Pfam PF00535 Glycosyl transferase family 2 15 155 7.3E-27 T 09-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 TK78_RS34510 367e2c46e51b30b1d1ae1f92bde5516d 544 Gene3D G3DSA:1.20.1250.20 286 441 1.0E-20 T 09-03-2017 TK78_RS34510 367e2c46e51b30b1d1ae1f92bde5516d 544 Gene3D G3DSA:1.20.1250.20 493 517 1.0E-20 T 09-03-2017 TK78_RS34510 367e2c46e51b30b1d1ae1f92bde5516d 544 Gene3D G3DSA:1.20.1250.20 30 214 7.6E-36 T 09-03-2017 TK78_RS34510 367e2c46e51b30b1d1ae1f92bde5516d 544 Pfam PF07690 Major Facilitator Superfamily 38 430 4.0E-48 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS34510 367e2c46e51b30b1d1ae1f92bde5516d 544 PRINTS PR01036 Tetracycline resistance protein TetB signature 421 440 1.5E-5 T 09-03-2017 TK78_RS34510 367e2c46e51b30b1d1ae1f92bde5516d 544 PRINTS PR01036 Tetracycline resistance protein TetB signature 36 60 1.5E-5 T 09-03-2017 TK78_RS34510 367e2c46e51b30b1d1ae1f92bde5516d 544 PRINTS PR01036 Tetracycline resistance protein TetB signature 127 147 1.5E-5 T 09-03-2017 TK78_RS34510 367e2c46e51b30b1d1ae1f92bde5516d 544 SUPERFAMILY SSF103473 268 440 1.16E-68 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS34510 367e2c46e51b30b1d1ae1f92bde5516d 544 SUPERFAMILY SSF103473 492 522 1.16E-68 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS34510 367e2c46e51b30b1d1ae1f92bde5516d 544 SUPERFAMILY SSF103473 8 219 1.16E-68 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS06370 a4d95ae7fd30b871634f6737d7770662 133 Pfam PF01042 Endoribonuclease L-PSP 12 131 2.3E-19 T 09-03-2017 IPR006175 YjgF/YER057c/UK114 family TK78_RS06370 a4d95ae7fd30b871634f6737d7770662 133 SUPERFAMILY SSF55298 9 133 1.37E-28 T 09-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like TK78_RS06370 a4d95ae7fd30b871634f6737d7770662 133 Gene3D G3DSA:3.30.1330.40 5 133 2.2E-31 T 09-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like TK78_RS29845 0c775b498a384006188c524f5ae1bc22 323 SUPERFAMILY SSF51430 47 308 2.36E-34 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS29845 0c775b498a384006188c524f5ae1bc22 323 Gene3D G3DSA:3.20.20.100 47 311 2.5E-32 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS29845 0c775b498a384006188c524f5ae1bc22 323 Pfam PF00248 Aldo/keto reductase family 50 307 1.1E-23 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS30820 4b8792473f2fc9ca9eb9de3e40bf0ea1 501 SUPERFAMILY SSF55931 38 465 5.98E-47 T 09-03-2017 TK78_RS30820 4b8792473f2fc9ca9eb9de3e40bf0ea1 501 PIRSF PIRSF012666 1 498 1.0E-217 T 09-03-2017 IPR016602 Uncharacterised conserved protein UCP012666 TK78_RS15525 bbb14107beaf44e0082c706928230dc5 223 Pfam PF10935 Protein of unknown function (DUF2637) 4 120 2.4E-21 T 09-03-2017 IPR021235 Protein of unknown function DUF2637 TK78_RS08465 42a869aabd28ab4c24b38a9e1758ff17 193 Gene3D G3DSA:3.40.50.300 11 186 1.3E-14 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08465 42a869aabd28ab4c24b38a9e1758ff17 193 SUPERFAMILY SSF52540 16 190 5.33E-22 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS08465 42a869aabd28ab4c24b38a9e1758ff17 193 Pfam PF03029 Conserved hypothetical ATP binding protein 21 188 7.9E-28 T 09-03-2017 IPR004130 GPN-loop GTPase TK78_RS30700 11c3d845ef1562244ffccce0a48a4613 189 Gene3D G3DSA:3.90.79.10 20 125 1.5E-15 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS30700 11c3d845ef1562244ffccce0a48a4613 189 ProSitePatterns PS00893 Nudix box signature. 94 115 - T 09-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 TK78_RS30700 11c3d845ef1562244ffccce0a48a4613 189 SUPERFAMILY SSF55811 17 139 6.23E-20 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS30700 11c3d845ef1562244ffccce0a48a4613 189 Pfam PF00293 NUDIX domain 59 129 3.3E-11 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS24185 d459f4e75964bafa4c2922d03974278f 773 TIGRFAM TIGR00217 malQ: 4-alpha-glucanotransferase 190 735 4.1E-90 T 09-03-2017 IPR003385 Glycoside hydrolase, family 77 GO:0004134|GO:0005975 KEGG: 00500+2.4.1.25|MetaCyc: PWY-5941|MetaCyc: PWY-6724|MetaCyc: PWY-6737|MetaCyc: PWY-7238 TK78_RS24185 d459f4e75964bafa4c2922d03974278f 773 Pfam PF02446 4-alpha-glucanotransferase 229 731 1.6E-112 T 09-03-2017 IPR003385 Glycoside hydrolase, family 77 GO:0004134|GO:0005975 KEGG: 00500+2.4.1.25|MetaCyc: PWY-5941|MetaCyc: PWY-6724|MetaCyc: PWY-6737|MetaCyc: PWY-7238 TK78_RS24185 d459f4e75964bafa4c2922d03974278f 773 Gene3D G3DSA:3.20.20.80 221 738 4.6E-160 T 09-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 TK78_RS24185 d459f4e75964bafa4c2922d03974278f 773 SUPERFAMILY SSF51445 223 648 9.13E-135 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS24185 d459f4e75964bafa4c2922d03974278f 773 SUPERFAMILY SSF51445 677 754 9.13E-135 T 09-03-2017 IPR017853 Glycoside hydrolase superfamily TK78_RS24660 a11f374a3f569c2b2f964f8808e26c83 832 Pfam PF00753 Metallo-beta-lactamase superfamily 584 767 1.3E-9 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS24660 a11f374a3f569c2b2f964f8808e26c83 832 Gene3D G3DSA:3.60.15.10 581 828 1.3E-18 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS24660 a11f374a3f569c2b2f964f8808e26c83 832 TIGRFAM TIGR00360 ComEC_N-term: ComEC/Rec2-related protein 285 461 1.5E-12 T 09-03-2017 IPR004477 ComEC/Rec2-related protein TK78_RS24660 a11f374a3f569c2b2f964f8808e26c83 832 SUPERFAMILY SSF56281 573 826 2.62E-31 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS24660 a11f374a3f569c2b2f964f8808e26c83 832 Pfam PF03772 Competence protein 263 537 2.2E-38 T 09-03-2017 IPR004477 ComEC/Rec2-related protein TK78_RS24660 a11f374a3f569c2b2f964f8808e26c83 832 SMART SM00849 586 786 1.3E-7 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS28890 2e04b7779993afaa174eaf19506b7eaf 165 Gene3D G3DSA:1.20.90.10 31 150 2.3E-43 T 09-03-2017 IPR016090 Phospholipase A2 domain KEGG: 00564+3.1.1.4|KEGG: 00565+3.1.1.4|KEGG: 00590+3.1.1.4|KEGG: 00591+3.1.1.4|KEGG: 00592+3.1.1.4|MetaCyc: PWY-6803|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7417 TK78_RS28890 2e04b7779993afaa174eaf19506b7eaf 165 Pfam PF09056 Prokaryotic phospholipase A2 46 150 3.0E-35 T 09-03-2017 IPR015141 Phospholipase A2, prokaryotic/fungal TK78_RS28890 2e04b7779993afaa174eaf19506b7eaf 165 SUPERFAMILY SSF48619 30 150 1.74E-40 T 09-03-2017 IPR016090 Phospholipase A2 domain KEGG: 00564+3.1.1.4|KEGG: 00565+3.1.1.4|KEGG: 00590+3.1.1.4|KEGG: 00591+3.1.1.4|KEGG: 00592+3.1.1.4|MetaCyc: PWY-6803|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7417 TK78_RS15800 1c5cc1c66646875996c9c1ed7dad7467 146 SMART SM00347 33 135 4.3E-16 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS15800 1c5cc1c66646875996c9c1ed7dad7467 146 Gene3D G3DSA:1.10.10.10 2 135 1.1E-29 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS15800 1c5cc1c66646875996c9c1ed7dad7467 146 Pfam PF12802 MarR family 39 99 2.9E-11 T 09-03-2017 TK78_RS15800 1c5cc1c66646875996c9c1ed7dad7467 146 SUPERFAMILY SSF46785 8 144 4.18E-25 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS14390 8a4d503c34c2dd5f344d766e2130cd15 322 SUPERFAMILY SSF103481 47 135 1.7E-15 T 09-03-2017 TK78_RS14390 8a4d503c34c2dd5f344d766e2130cd15 322 SUPERFAMILY SSF103481 178 277 2.62E-16 T 09-03-2017 TK78_RS14390 8a4d503c34c2dd5f344d766e2130cd15 322 Pfam PF00892 EamA-like transporter family 144 276 3.1E-22 T 09-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 TK78_RS14390 8a4d503c34c2dd5f344d766e2130cd15 322 Pfam PF00892 EamA-like transporter family 7 135 1.4E-17 T 09-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 TK78_RS30290 f4e8472b71b9184327a5ff313ae7c80b 166 Pfam PF01381 Helix-turn-helix 13 69 1.2E-8 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS30290 f4e8472b71b9184327a5ff313ae7c80b 166 Gene3D G3DSA:1.10.260.40 3 75 4.7E-12 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS30290 f4e8472b71b9184327a5ff313ae7c80b 166 SUPERFAMILY SSF47413 4 74 4.44E-9 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS30290 f4e8472b71b9184327a5ff313ae7c80b 166 SMART SM00530 12 69 2.1E-6 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS32925 eba622c96183d83790c31465069b0c5f 317 Pfam PF06189 5'-nucleotidase 39 305 2.5E-104 T 09-03-2017 IPR010394 5-nucleotidase GO:0000166|GO:0000287|GO:0005737|GO:0008253|GO:0009117 KEGG: 00230+3.1.3.5|KEGG: 00240+3.1.3.5|KEGG: 00760+3.1.3.5|MetaCyc: PWY-5381|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-6606|MetaCyc: PWY-6607|MetaCyc: PWY-6608|MetaCyc: PWY-7185|Reactome: R-HSA-74259 TK78_RS32595 412fd02fb72fba1fdf952aad1a205912 353 SUPERFAMILY SSF51004 27 335 9.68E-37 T 09-03-2017 IPR011048 Cytochrome cd1-nitrite reductase-like, haem d1 domain TK78_RS32595 412fd02fb72fba1fdf952aad1a205912 353 Pfam PF10282 Lactonase, 7-bladed beta-propeller 9 352 3.9E-94 T 09-03-2017 IPR019405 Lactonase, 7-bladed beta propeller KEGG: 00030+3.1.1.31 TK78_RS32595 412fd02fb72fba1fdf952aad1a205912 353 Gene3D G3DSA:2.130.10.10 8 353 2.4E-91 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS26595 be786fc5d495abe3e4a4575e2aa5b960 244 Gene3D G3DSA:3.40.50.1820 4 238 4.3E-36 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS26595 be786fc5d495abe3e4a4575e2aa5b960 244 SUPERFAMILY SSF53474 5 235 7.15E-25 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS26595 be786fc5d495abe3e4a4575e2aa5b960 244 Pfam PF12697 Alpha/beta hydrolase family 5 229 5.3E-11 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS24740 1dad66fc60a9f5ffb041e86612ade412 298 Gene3D G3DSA:2.120.10.30 9 284 3.4E-40 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS24740 1dad66fc60a9f5ffb041e86612ade412 298 SUPERFAMILY SSF63829 6 272 5.67E-36 T 09-03-2017 TK78_RS24740 1dad66fc60a9f5ffb041e86612ade412 298 Pfam PF08450 SMP-30/Gluconolaconase/LRE-like region 17 272 1.0E-33 T 09-03-2017 IPR013658 SMP-30/Gluconolactonase/LRE-like region TK78_RS26795 fae1a89ef0ec8ddf054599a8e1ff4d98 549 Pfam PF13631 Cytochrome b(N-terminal)/b6/petB 128 301 5.1E-57 T 09-03-2017 IPR005797 Cytochrome b/b6, N-terminal GO:0009055|GO:0016020|GO:0016491 Reactome: R-HSA-611105 TK78_RS26795 fae1a89ef0ec8ddf054599a8e1ff4d98 549 SUPERFAMILY SSF81342 27 303 5.65E-62 T 09-03-2017 IPR016174 Di-haem cytochrome, transmembrane GO:0016020|GO:0022904 Reactome: R-HSA-611105 TK78_RS26795 fae1a89ef0ec8ddf054599a8e1ff4d98 549 Gene3D G3DSA:1.20.810.10 27 448 1.2E-89 T 09-03-2017 IPR027387 Cytochrome b/b6-like domain Reactome: R-HSA-611105 TK78_RS12115 fc98bfa7b03c2ff61fc6c276a65ebcaa 384 TIGRFAM TIGR01430 aden_deam: adenosine deaminase 18 354 1.2E-73 T 09-03-2017 IPR006330 Adenosine/adenine deaminase GO:0019239 Reactome: R-HSA-74217 TK78_RS12115 fc98bfa7b03c2ff61fc6c276a65ebcaa 384 Hamap MF_00540 Adenosine deaminase [add]. 12 357 55.412 T 09-03-2017 IPR028893 Adenosine deaminase GO:0004000|GO:0009168 KEGG: 00230+3.5.4.4|MetaCyc: PWY-6609|MetaCyc: PWY-6611|MetaCyc: PWY-7179|MetaCyc: PWY-7179-1|Reactome: R-HSA-74217 TK78_RS12115 fc98bfa7b03c2ff61fc6c276a65ebcaa 384 Gene3D G3DSA:3.20.20.140 14 356 7.4E-104 T 09-03-2017 TK78_RS12115 fc98bfa7b03c2ff61fc6c276a65ebcaa 384 Pfam PF00962 Adenosine/AMP deaminase 17 354 1.4E-86 T 09-03-2017 IPR001365 Adenosine/AMP deaminase domain GO:0019239 Reactome: R-HSA-74217 TK78_RS12115 fc98bfa7b03c2ff61fc6c276a65ebcaa 384 SUPERFAMILY SSF51556 12 350 3.58E-73 T 09-03-2017 IPR032466 Metal-dependent hydrolase TK78_RS10725 be1cce19b77eda73363cafba15522b06 412 Gene3D G3DSA:1.20.1250.20 221 387 1.3E-12 T 09-03-2017 TK78_RS10725 be1cce19b77eda73363cafba15522b06 412 Gene3D G3DSA:1.20.1250.20 21 200 2.0E-28 T 09-03-2017 TK78_RS10725 be1cce19b77eda73363cafba15522b06 412 PRINTS PR01035 Tetracycline resistance protein signature 32 48 8.4E-12 T 09-03-2017 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 TK78_RS10725 be1cce19b77eda73363cafba15522b06 412 PRINTS PR01035 Tetracycline resistance protein signature 174 194 8.4E-12 T 09-03-2017 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 TK78_RS10725 be1cce19b77eda73363cafba15522b06 412 PRINTS PR01035 Tetracycline resistance protein signature 146 168 8.4E-12 T 09-03-2017 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 TK78_RS10725 be1cce19b77eda73363cafba15522b06 412 Pfam PF07690 Major Facilitator Superfamily 29 353 1.5E-29 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS10725 be1cce19b77eda73363cafba15522b06 412 SUPERFAMILY SSF103473 19 387 4.58E-53 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS06290 828dfb5903c0ade2584c38c1bb6873d9 752 SMART SM00282 599 736 2.3E-5 T 09-03-2017 IPR001791 Laminin G domain TK78_RS06290 828dfb5903c0ade2584c38c1bb6873d9 752 SUPERFAMILY SSF49265 423 521 8.53E-6 T 09-03-2017 IPR003961 Fibronectin type III GO:0005515 TK78_RS06290 828dfb5903c0ade2584c38c1bb6873d9 752 SMART SM00560 599 741 0.001 T 09-03-2017 IPR006558 LamG-like jellyroll fold TK78_RS06290 828dfb5903c0ade2584c38c1bb6873d9 752 Pfam PF13385 Concanavalin A-like lectin/glucanases superfamily 584 743 8.8E-23 T 09-03-2017 TK78_RS06290 828dfb5903c0ade2584c38c1bb6873d9 752 Gene3D G3DSA:2.130.10.10 120 188 3.0E-7 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS06290 828dfb5903c0ade2584c38c1bb6873d9 752 SUPERFAMILY SSF49899 526 749 9.17E-34 T 09-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain TK78_RS06290 828dfb5903c0ade2584c38c1bb6873d9 752 SUPERFAMILY SSF50998 47 336 2.67E-10 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS06290 828dfb5903c0ade2584c38c1bb6873d9 752 Gene3D G3DSA:2.60.120.200 530 749 5.9E-31 T 09-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain TK78_RS06290 828dfb5903c0ade2584c38c1bb6873d9 752 Gene3D G3DSA:2.60.40.10 430 517 5.4E-8 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS22265 af5a5b0d5020a5883c54ffc1fd820225 305 PIRSF PIRSF003097 1 305 7.2E-75 T 09-03-2017 IPR004513 Cell division protein FtsX GO:0007049|GO:0016021 TK78_RS22265 af5a5b0d5020a5883c54ffc1fd820225 305 Pfam PF02687 FtsX-like permease family 183 304 2.9E-11 T 09-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 TK78_RS10320 5ab33391ad186f2ad5129cd3f4152fbc 169 Gene3D G3DSA:3.40.630.30 1 153 3.3E-23 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS10320 5ab33391ad186f2ad5129cd3f4152fbc 169 Pfam PF00583 Acetyltransferase (GNAT) family 60 142 1.2E-11 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS10320 5ab33391ad186f2ad5129cd3f4152fbc 169 SUPERFAMILY SSF55729 1 155 5.23E-24 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS12405 6be21bc42d3ef9004063c11dbaa1faf9 449 Gene3D G3DSA:3.40.710.10 69 325 4.9E-70 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS12405 6be21bc42d3ef9004063c11dbaa1faf9 449 Pfam PF00768 D-alanyl-D-alanine carboxypeptidase 71 303 2.2E-36 T 09-03-2017 IPR001967 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, N-terminal GO:0006508|GO:0009002 TK78_RS12405 6be21bc42d3ef9004063c11dbaa1faf9 449 SUPERFAMILY SSF56601 72 324 5.85E-45 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS12405 6be21bc42d3ef9004063c11dbaa1faf9 449 SUPERFAMILY SSF56601 5 32 5.85E-45 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS07385 ce5b7274735f44978dce23298bbf6c62 390 Gene3D G3DSA:2.40.10.10 145 273 1.3E-8 T 09-03-2017 TK78_RS07385 ce5b7274735f44978dce23298bbf6c62 390 SUPERFAMILY SSF50494 251 361 7.61E-18 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS07385 ce5b7274735f44978dce23298bbf6c62 390 SUPERFAMILY SSF50494 139 205 7.61E-18 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS19290 af8f7702f9c4f35fa960f1b7731cd971 299 Gene3D G3DSA:1.10.510.10 142 282 5.5E-31 T 09-03-2017 TK78_RS19290 af8f7702f9c4f35fa960f1b7731cd971 299 Gene3D G3DSA:3.30.200.20 16 141 1.3E-14 T 09-03-2017 TK78_RS19290 af8f7702f9c4f35fa960f1b7731cd971 299 SMART SM00220 19 288 2.0E-19 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS19290 af8f7702f9c4f35fa960f1b7731cd971 299 Pfam PF00069 Protein kinase domain 21 281 6.7E-34 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS19290 af8f7702f9c4f35fa960f1b7731cd971 299 SUPERFAMILY SSF56112 9 285 1.89E-44 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS18660 2195fbb3abe040f775c95bee480a3cca 141 Gene3D G3DSA:3.90.79.10 8 137 9.7E-31 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS18660 2195fbb3abe040f775c95bee480a3cca 141 SUPERFAMILY SSF55811 8 137 1.16E-29 T 09-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 TK78_RS18660 2195fbb3abe040f775c95bee480a3cca 141 PRINTS PR00502 NUDIX hydrolase family signature 40 54 6.1E-5 T 09-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 TK78_RS18660 2195fbb3abe040f775c95bee480a3cca 141 PRINTS PR00502 NUDIX hydrolase family signature 54 69 6.1E-5 T 09-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 TK78_RS18660 2195fbb3abe040f775c95bee480a3cca 141 ProSitePatterns PS00893 Nudix box signature. 45 66 - T 09-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 TK78_RS18660 2195fbb3abe040f775c95bee480a3cca 141 Pfam PF00293 NUDIX domain 11 124 1.3E-16 T 09-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 TK78_RS02610 2c6a3a73fbaa167183306f411fc5b98d 398 Pfam PF00067 Cytochrome P450 286 368 9.4E-12 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS02610 2c6a3a73fbaa167183306f411fc5b98d 398 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 340 349 - T 09-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 TK78_RS02610 2c6a3a73fbaa167183306f411fc5b98d 398 Gene3D G3DSA:1.10.630.10 5 398 1.9E-99 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS02610 2c6a3a73fbaa167183306f411fc5b98d 398 PRINTS PR00359 B-class P450 signature 149 164 1.7E-37 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS02610 2c6a3a73fbaa167183306f411fc5b98d 398 PRINTS PR00359 B-class P450 signature 187 209 1.7E-37 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS02610 2c6a3a73fbaa167183306f411fc5b98d 398 PRINTS PR00359 B-class P450 signature 288 315 1.7E-37 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS02610 2c6a3a73fbaa167183306f411fc5b98d 398 PRINTS PR00359 B-class P450 signature 338 347 1.7E-37 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS02610 2c6a3a73fbaa167183306f411fc5b98d 398 PRINTS PR00359 B-class P450 signature 316 331 1.7E-37 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS02610 2c6a3a73fbaa167183306f411fc5b98d 398 PRINTS PR00359 B-class P450 signature 85 96 1.7E-37 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS02610 2c6a3a73fbaa167183306f411fc5b98d 398 PRINTS PR00359 B-class P450 signature 132 148 1.7E-37 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS02610 2c6a3a73fbaa167183306f411fc5b98d 398 PRINTS PR00359 B-class P450 signature 347 358 1.7E-37 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS02610 2c6a3a73fbaa167183306f411fc5b98d 398 SUPERFAMILY SSF48264 14 398 5.63E-76 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS03645 952510bbad057a71b3597391d1a1a4dd 216 Pfam PF11303 Protein of unknown function (DUF3105) 86 208 1.7E-44 T 09-03-2017 IPR021454 Protein of unknown function DUF3105 TK78_RS08725 05ebf3270b3e924e40ec022e4ac4c522 521 Pfam PF02133 Permease for cytosine/purines, uracil, thiamine, allantoin 76 499 4.4E-38 T 09-03-2017 IPR001248 Purine-cytosine permease GO:0005215|GO:0016020|GO:0055085 TK78_RS08725 05ebf3270b3e924e40ec022e4ac4c522 521 PIRSF PIRSF002744 38 521 1.5E-95 T 09-03-2017 IPR026030 Purine-cytosine permease Fcy2/21/22 GO:0005215|GO:0016021|GO:0055085 TK78_RS11585 29747308413e45551234529568d74fb0 215 Gene3D G3DSA:3.30.1330.60 98 209 6.9E-29 T 09-03-2017 IPR006665 OmpA-like domain TK78_RS11585 29747308413e45551234529568d74fb0 215 PRINTS PR01021 OMPA domain signature 139 154 1.4E-5 T 09-03-2017 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 TK78_RS11585 29747308413e45551234529568d74fb0 215 PRINTS PR01021 OMPA domain signature 109 131 1.4E-5 T 09-03-2017 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 TK78_RS11585 29747308413e45551234529568d74fb0 215 PRINTS PR01021 OMPA domain signature 154 170 1.4E-5 T 09-03-2017 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 TK78_RS11585 29747308413e45551234529568d74fb0 215 Pfam PF00691 OmpA family 109 203 1.1E-14 T 09-03-2017 IPR006665 OmpA-like domain TK78_RS11585 29747308413e45551234529568d74fb0 215 SUPERFAMILY SSF103088 98 209 1.01E-27 T 09-03-2017 IPR006665 OmpA-like domain TK78_RS18010 38af09cb1f15329722e72f180ecc66ec 1201 Pfam PF02514 CobN/Magnesium Chelatase 100 1180 0.0 T 09-03-2017 IPR003672 CobN/magnesium chelatase GO:0009058 TK78_RS18010 38af09cb1f15329722e72f180ecc66ec 1201 TIGRFAM TIGR02257 cobalto_cobN: cobaltochelatase, CobN subunit 44 1194 0.0 T 09-03-2017 IPR011953 Cobaltochelatase, CobN subunit GO:0009236|GO:0051116 TK78_RS12940 c19f02b961e921d0a313959849acf319 139 SUPERFAMILY SSF55874 44 123 5.35E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS12940 c19f02b961e921d0a313959849acf319 139 Pfam PF13581 Histidine kinase-like ATPase domain 20 115 2.4E-9 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS15085 88a2b31df450434cbbd853ca72cd84c5 378 Pfam PF14907 Uncharacterised nucleotidyltransferase 37 319 1.7E-45 T 09-03-2017 TK78_RS11925 afefb2db3fb69dbe28373818958b3617 149 Pfam PF06271 RDD family 1 95 3.0E-9 T 09-03-2017 IPR010432 RDD TK78_RS31910 6ae778de4396a47c11fac54666536fe0 468 PIRSF PIRSF017804 1 468 1.2E-55 T 09-03-2017 IPR006707 Type VII secretion system membrane protein EccD TK78_RS31910 6ae778de4396a47c11fac54666536fe0 468 TIGRFAM TIGR03920 T7SS_EccD: type VII secretion integral membrane protein EccD 14 465 4.4E-59 T 09-03-2017 IPR006707 Type VII secretion system membrane protein EccD TK78_RS31910 6ae778de4396a47c11fac54666536fe0 468 Pfam PF08817 WXG100 protein secretion system (Wss), protein YukD 10 85 2.7E-21 T 09-03-2017 IPR024962 YukD-like TK78_RS24940 5670e21234f11839c3286f732f08ed43 254 SUPERFAMILY SSF81301 2 89 6.91E-9 T 09-03-2017 TK78_RS24940 5670e21234f11839c3286f732f08ed43 254 Pfam PF13427 Domain of unknown function (DUF4111) 140 240 4.6E-29 T 09-03-2017 IPR025184 Domain of unknown function DUF4111 TK78_RS24940 5670e21234f11839c3286f732f08ed43 254 PIRSF PIRSF000819 4 252 6.1E-69 T 09-03-2017 IPR024172 Streptomycin 3''-adenylyltransferase GO:0009012|GO:0046677 TK78_RS24940 5670e21234f11839c3286f732f08ed43 254 Pfam PF01909 Nucleotidyltransferase domain 20 52 6.9E-5 T 09-03-2017 IPR002934 Polymerase, nucleotidyl transferase domain GO:0016779 TK78_RS24940 5670e21234f11839c3286f732f08ed43 254 Gene3D G3DSA:3.30.460.10 10 96 1.8E-10 T 09-03-2017 TK78_RS04980 975c42ca0a0368730ed191d90c0da910 467 Pfam PF00860 Permease family 37 418 7.4E-91 T 09-03-2017 IPR006043 Xanthine/uracil/vitamin C permease GO:0005215|GO:0006810|GO:0016020|GO:0055085 TK78_RS04980 975c42ca0a0368730ed191d90c0da910 467 TIGRFAM TIGR00801 ncs2: uracil-xanthine permease 34 449 1.3E-104 T 09-03-2017 IPR006042 Xanthine/uracil permease GO:0005215|GO:0016020|GO:0055085 Reactome: R-HSA-196836 TK78_RS04980 975c42ca0a0368730ed191d90c0da910 467 TIGRFAM TIGR03173 pbuX: xanthine permease 41 452 2.0E-142 T 09-03-2017 IPR017588 Uric acid permease UacT-like GO:0006810|GO:0016021 TK78_RS04980 975c42ca0a0368730ed191d90c0da910 467 ProSitePatterns PS01116 Xanthine/uracil permeases family signature. 367 387 - T 09-03-2017 IPR006042 Xanthine/uracil permease GO:0005215|GO:0016020|GO:0055085 Reactome: R-HSA-196836 TK78_RS17565 0f762ca430179ce08dff14e623cd5168 307 SUPERFAMILY SSF46565 172 211 7.72E-6 T 09-03-2017 IPR001623 DnaJ domain TK78_RS17565 0f762ca430179ce08dff14e623cd5168 307 Gene3D G3DSA:1.10.287.110 172 210 5.0E-5 T 09-03-2017 IPR001623 DnaJ domain TK78_RS32615 3eb53f4a4641592bafda9388506e46f0 361 SUPERFAMILY SSF110296 4 357 3.27E-57 T 09-03-2017 TK78_RS32615 3eb53f4a4641592bafda9388506e46f0 361 Gene3D G3DSA:2.130.10.10 6 355 1.6E-83 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS04585 b1efe4b97466cd18314590ee9f3f80ba 355 Gene3D G3DSA:3.90.226.10 3 197 2.3E-58 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS04585 b1efe4b97466cd18314590ee9f3f80ba 355 SUPERFAMILY SSF52096 247 317 2.59E-67 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS04585 b1efe4b97466cd18314590ee9f3f80ba 355 SUPERFAMILY SSF52096 1 195 2.59E-67 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS04585 b1efe4b97466cd18314590ee9f3f80ba 355 Gene3D G3DSA:1.10.12.10 260 318 2.6E-6 T 09-03-2017 IPR014748 Crontonase, C-terminal TK78_RS04585 b1efe4b97466cd18314590ee9f3f80ba 355 Pfam PF16113 Enoyl-CoA hydratase/isomerase 15 334 1.9E-121 T 09-03-2017 IPR032259 Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type GO:0003860 Reactome: R-HSA-70895 TK78_RS11215 2f25b76231aa5fd12474d8589d4e12f1 141 SUPERFAMILY SSF55298 12 137 1.57E-22 T 09-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like TK78_RS11215 2f25b76231aa5fd12474d8589d4e12f1 141 Gene3D G3DSA:3.30.1330.40 17 138 5.1E-28 T 09-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like TK78_RS11215 2f25b76231aa5fd12474d8589d4e12f1 141 Pfam PF01042 Endoribonuclease L-PSP 19 136 5.9E-18 T 09-03-2017 IPR006175 YjgF/YER057c/UK114 family TK78_RS06850 7b7f47bbe6b4940e298759c141b51445 678 Pfam PF13520 Amino acid permease 57 465 2.4E-31 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS01495 fbc98f08e87ecfffebf81c85b2b21f56 285 SUPERFAMILY SSF161098 75 263 9.68E-26 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS01495 fbc98f08e87ecfffebf81c85b2b21f56 285 Gene3D G3DSA:1.10.3720.10 75 277 5.3E-24 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS01495 fbc98f08e87ecfffebf81c85b2b21f56 285 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 96 279 9.7E-25 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS12755 232127bbfa9384b6346da149516c599e 374 Gene3D G3DSA:3.40.50.2300 190 362 5.2E-31 T 09-03-2017 TK78_RS12755 232127bbfa9384b6346da149516c599e 374 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 40 58 5.6E-6 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS12755 232127bbfa9384b6346da149516c599e 374 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 26 40 5.6E-6 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS12755 232127bbfa9384b6346da149516c599e 374 SUPERFAMILY SSF46785 7 60 5.68E-10 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS12755 232127bbfa9384b6346da149516c599e 374 Gene3D G3DSA:1.10.10.10 7 55 1.9E-10 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS12755 232127bbfa9384b6346da149516c599e 374 Pfam PF13377 Periplasmic binding protein-like domain 190 360 4.3E-27 T 09-03-2017 TK78_RS12755 232127bbfa9384b6346da149516c599e 374 SMART SM00420 8 60 5.3E-14 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS12755 232127bbfa9384b6346da149516c599e 374 SUPERFAMILY SSF53822 84 365 1.43E-32 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS12755 232127bbfa9384b6346da149516c599e 374 ProSitePatterns PS00894 DeoR-type HTH domain signature. 8 42 - T 09-03-2017 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 TK78_RS12755 232127bbfa9384b6346da149516c599e 374 Gene3D G3DSA:3.40.50.2300 77 189 1.1E-11 T 09-03-2017 TK78_RS12755 232127bbfa9384b6346da149516c599e 374 Pfam PF08220 DeoR-like helix-turn-helix domain 8 59 6.8E-14 T 09-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 TK78_RS28205 78c4fd5c94bff217739493aa48f7ba25 323 TIGRFAM TIGR01167 LPXTG_anchor: LPXTG cell wall anchor domain 285 318 0.0015 T 09-03-2017 IPR019931 LPXTG cell wall anchor domain TK78_RS30085 403b097a09963238abc96f61bf87f72f 386 Pfam PF13692 Glycosyl transferases group 1 187 328 3.2E-30 T 09-03-2017 TK78_RS30085 403b097a09963238abc96f61bf87f72f 386 SUPERFAMILY SSF53756 2 363 2.04E-84 T 09-03-2017 TK78_RS30085 403b097a09963238abc96f61bf87f72f 386 Pfam PF13439 Glycosyltransferase Family 4 14 172 5.6E-34 T 09-03-2017 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 TK78_RS30085 403b097a09963238abc96f61bf87f72f 386 Gene3D G3DSA:3.40.50.2000 186 339 1.1E-25 T 09-03-2017 TK78_RS26560 bc5a162328b6a10e6ca537780818e053 155 Pfam PF06271 RDD family 43 148 6.7E-13 T 09-03-2017 IPR010432 RDD TK78_RS26560 bc5a162328b6a10e6ca537780818e053 155 PIRSF PIRSF021697 3 155 1.8E-52 T 09-03-2017 IPR016795 Uncharacterised conserved protein UCP021697, membrane TK78_RS04200 0fb30d0e5aa2be99fc54cdc41bcfc0f6 194 SUPERFAMILY SSF48371 43 189 1.12E-9 T 09-03-2017 IPR016024 Armadillo-type fold GO:0005488 TK78_RS04200 0fb30d0e5aa2be99fc54cdc41bcfc0f6 194 Gene3D G3DSA:1.25.10.10 129 191 3.0E-10 T 09-03-2017 IPR011989 Armadillo-like helical TK78_RS04200 0fb30d0e5aa2be99fc54cdc41bcfc0f6 194 Gene3D G3DSA:1.25.10.10 52 96 3.0E-10 T 09-03-2017 IPR011989 Armadillo-like helical TK78_RS04200 0fb30d0e5aa2be99fc54cdc41bcfc0f6 194 SMART SM00567 E-Z type HEAT repeats 49 78 29.0 T 09-03-2017 IPR004155 PBS lyase HEAT-like repeat Reactome: R-HSA-204626 TK78_RS04200 0fb30d0e5aa2be99fc54cdc41bcfc0f6 194 SMART SM00567 E-Z type HEAT repeats 149 178 1.1 T 09-03-2017 IPR004155 PBS lyase HEAT-like repeat Reactome: R-HSA-204626 TK78_RS28140 e56d523e17afc1b495a5b2c58f3be880 203 Gene3D G3DSA:2.60.120.200 80 190 3.9E-9 T 09-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain TK78_RS28140 e56d523e17afc1b495a5b2c58f3be880 203 Pfam PF07081 Protein of unknown function (DUF1349) 20 191 7.2E-34 T 09-03-2017 IPR009784 Protein of unknown function DUF1349 TK78_RS28140 e56d523e17afc1b495a5b2c58f3be880 203 SUPERFAMILY SSF49899 62 190 1.42E-11 T 09-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain TK78_RS09720 92b8531d04cc469687e3de9fa92b4977 213 SMART SM00226 16 169 5.0E-7 T 09-03-2017 IPR023485 Phosphotyrosine protein phosphatase I superfamily TK78_RS09720 92b8531d04cc469687e3de9fa92b4977 213 Gene3D G3DSA:3.40.50.270 169 206 7.4E-31 T 09-03-2017 TK78_RS09720 92b8531d04cc469687e3de9fa92b4977 213 Gene3D G3DSA:3.40.50.270 16 129 7.4E-31 T 09-03-2017 TK78_RS09720 92b8531d04cc469687e3de9fa92b4977 213 SUPERFAMILY SSF52788 176 204 1.44E-22 T 09-03-2017 IPR023485 Phosphotyrosine protein phosphatase I superfamily TK78_RS09720 92b8531d04cc469687e3de9fa92b4977 213 SUPERFAMILY SSF52788 15 138 1.44E-22 T 09-03-2017 IPR023485 Phosphotyrosine protein phosphatase I superfamily TK78_RS09720 92b8531d04cc469687e3de9fa92b4977 213 Pfam PF01451 Low molecular weight phosphotyrosine protein phosphatase 18 148 3.5E-15 T 09-03-2017 IPR023485 Phosphotyrosine protein phosphatase I superfamily TK78_RS21905 4c0b223b5f9e76d5cb36aed47f659a4e 189 Pfam PF03061 Thioesterase superfamily 44 114 3.0E-20 T 09-03-2017 IPR006683 Thioesterase domain Reactome: R-HSA-75105 TK78_RS21905 4c0b223b5f9e76d5cb36aed47f659a4e 189 Gene3D G3DSA:3.10.129.10 25 177 3.7E-53 T 09-03-2017 IPR029069 HotDog domain TK78_RS21905 4c0b223b5f9e76d5cb36aed47f659a4e 189 SUPERFAMILY SSF54637 25 178 2.96E-43 T 09-03-2017 IPR029069 HotDog domain TK78_RS28250 300cf62a537459d3a7da7d6c7128f46e 421 Pfam PF01384 Phosphate transporter family 172 324 4.1E-43 T 09-03-2017 IPR001204 Phosphate transporter GO:0005315|GO:0006817|GO:0016020 Reactome: R-HSA-427652 TK78_RS28250 300cf62a537459d3a7da7d6c7128f46e 421 Pfam PF01384 Phosphate transporter family 22 161 3.7E-34 T 09-03-2017 IPR001204 Phosphate transporter GO:0005315|GO:0006817|GO:0016020 Reactome: R-HSA-427652 TK78_RS05875 118fcbce2b6947454169f912b6df93a5 458 Gene3D G3DSA:3.20.20.150 2 273 2.2E-81 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS05875 118fcbce2b6947454169f912b6df93a5 458 Pfam PF05114 Protein of unknown function (DUF692) 4 270 4.0E-78 T 09-03-2017 IPR007801 Uncharacterised protein family UPF0276 TK78_RS05875 118fcbce2b6947454169f912b6df93a5 458 SUPERFAMILY SSF51658 21 248 6.63E-12 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS27390 00a220d2ff051d349c81d03a7a68da88 397 Pfam PF03747 ADP-ribosylglycohydrolase 30 346 6.5E-48 T 09-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 TK78_RS27390 00a220d2ff051d349c81d03a7a68da88 397 SUPERFAMILY SSF101478 21 370 5.23E-44 T 09-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 TK78_RS17335 7afad18fef4bac864a78fdfc1aa25bf9 238 Gene3D G3DSA:3.40.50.150 26 210 1.6E-60 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS17335 7afad18fef4bac864a78fdfc1aa25bf9 238 Pfam PF02527 rRNA small subunit methyltransferase G 25 197 3.6E-55 T 09-03-2017 IPR003682 rRNA small subunit methyltransferase G GO:0005737|GO:0006364|GO:0008649 TK78_RS17335 7afad18fef4bac864a78fdfc1aa25bf9 238 SUPERFAMILY SSF53335 25 206 1.74E-30 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS17335 7afad18fef4bac864a78fdfc1aa25bf9 238 Hamap MF_00074 Ribosomal RNA small subunit methyltransferase G [rsmG]. 14 213 24.367 T 09-03-2017 IPR003682 rRNA small subunit methyltransferase G GO:0005737|GO:0006364|GO:0008649 TK78_RS17335 7afad18fef4bac864a78fdfc1aa25bf9 238 TIGRFAM TIGR00138 rsmG_gidB: 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG 27 193 1.6E-38 T 09-03-2017 IPR003682 rRNA small subunit methyltransferase G GO:0005737|GO:0006364|GO:0008649 TK78_RS21705 51464174fc5dcf4563601404f561ff98 162 SUPERFAMILY SSF103196 2 125 2.27E-23 T 09-03-2017 TK78_RS21705 51464174fc5dcf4563601404f561ff98 162 SMART SM00960 11 99 1.2E-15 T 09-03-2017 IPR004942 Roadblock/LAMTOR2 domain TK78_RS21705 51464174fc5dcf4563601404f561ff98 162 Gene3D G3DSA:3.30.450.30 1 125 2.4E-30 T 09-03-2017 TK78_RS21705 51464174fc5dcf4563601404f561ff98 162 Pfam PF03259 Roadblock/LC7 domain 12 99 9.1E-16 T 09-03-2017 IPR004942 Roadblock/LAMTOR2 domain TK78_RS25555 f20f6b77c56af901d60394956bdc455d 371 SUPERFAMILY SSF53474 197 320 1.31E-5 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS25555 f20f6b77c56af901d60394956bdc455d 371 SUPERFAMILY SSF53474 114 135 1.31E-5 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS25555 f20f6b77c56af901d60394956bdc455d 371 Pfam PF06259 Alpha/beta hydrolase 128 295 1.5E-45 T 09-03-2017 IPR010427 Protein of unknown function DUF1023 TK78_RS32845 61c3a7979d2a0c591d9824ad234bb8b4 159 Gene3D G3DSA:3.30.530.20 17 154 1.3E-18 T 09-03-2017 IPR023393 START-like domain TK78_RS32845 61c3a7979d2a0c591d9824ad234bb8b4 159 Pfam PF10604 Polyketide cyclase / dehydrase and lipid transport 22 154 2.8E-22 T 09-03-2017 IPR019587 Polyketide cyclase/dehydrase TK78_RS32845 61c3a7979d2a0c591d9824ad234bb8b4 159 SUPERFAMILY SSF55961 17 154 1.48E-21 T 09-03-2017 TK78_RS21580 4ce601ed9ab579c3defa86f5bd0054b9 159 Pfam PF04977 Septum formation initiator 47 124 5.2E-16 T 09-03-2017 IPR007060 Septum formation initiator FtsL/DivIC GO:0007049 TK78_RS24600 0f21b748ebfcc5ecbc1b1f020e9c50e5 143 Gene3D G3DSA:3.30.460.10 7 113 3.7E-32 T 09-03-2017 TK78_RS24600 0f21b748ebfcc5ecbc1b1f020e9c50e5 143 TIGRFAM TIGR00090 rsfS_iojap_ybeB: ribosome silencing factor 11 109 9.1E-29 T 09-03-2017 IPR004394 Protein Iojap/ribosomal silencing factor RsfS TK78_RS24600 0f21b748ebfcc5ecbc1b1f020e9c50e5 143 Pfam PF02410 Ribosomal silencing factor during starvation 14 109 1.8E-21 T 09-03-2017 TK78_RS24600 0f21b748ebfcc5ecbc1b1f020e9c50e5 143 Hamap MF_01477 Ribosomal silencing factor RsfS [rsfS]. 7 110 22.539 T 09-03-2017 IPR004394 Protein Iojap/ribosomal silencing factor RsfS TK78_RS24600 0f21b748ebfcc5ecbc1b1f020e9c50e5 143 SUPERFAMILY SSF81301 7 118 4.74E-34 T 09-03-2017 TK78_RS33855 6b00ad2f88362f0dc5db0ad62a3b256c 402 Gene3D G3DSA:3.40.50.1820 163 400 1.5E-61 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS33855 6b00ad2f88362f0dc5db0ad62a3b256c 402 Pfam PF11806 Domain of unknown function (DUF3327) 48 168 4.2E-29 T 09-03-2017 IPR021764 Enterochelin esterase, N-terminal GO:0005506|GO:0005737|GO:0006826|GO:0008849 TK78_RS33855 6b00ad2f88362f0dc5db0ad62a3b256c 402 Pfam PF00756 Putative esterase 190 397 3.8E-29 T 09-03-2017 IPR000801 Putative esterase Reactome: R-HSA-156590 TK78_RS33855 6b00ad2f88362f0dc5db0ad62a3b256c 402 SUPERFAMILY SSF53474 188 399 2.29E-40 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS33855 6b00ad2f88362f0dc5db0ad62a3b256c 402 SUPERFAMILY SSF81296 19 165 1.54E-30 T 09-03-2017 IPR014756 Immunoglobulin E-set TK78_RS33855 6b00ad2f88362f0dc5db0ad62a3b256c 402 Gene3D G3DSA:2.60.40.10 15 155 3.7E-34 T 09-03-2017 IPR013783 Immunoglobulin-like fold TK78_RS31265 61a3adac09705482bfcbf5b234757960 408 SUPERFAMILY SSF103473 24 397 9.02E-26 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS31265 61a3adac09705482bfcbf5b234757960 408 Gene3D G3DSA:1.20.1250.20 25 197 7.1E-20 T 09-03-2017 TK78_RS31265 61a3adac09705482bfcbf5b234757960 408 Pfam PF07690 Major Facilitator Superfamily 26 314 1.0E-12 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS02370 9f6129c1ee79ca9142702ce2a583fbbc 157 Pfam PF13581 Histidine kinase-like ATPase domain 49 150 5.4E-7 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS02370 9f6129c1ee79ca9142702ce2a583fbbc 157 SUPERFAMILY SSF55874 66 143 5.34E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS12985 59048909d8dde5a6565364733e6bc889 367 SMART SM00331 139 361 1.1E-31 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS12985 59048909d8dde5a6565364733e6bc889 367 SUPERFAMILY SSF81606 155 359 1.31E-8 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS12985 59048909d8dde5a6565364733e6bc889 367 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 167 361 4.5E-41 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS12985 59048909d8dde5a6565364733e6bc889 367 Gene3D G3DSA:3.60.40.10 278 359 3.8E-4 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS24165 fac83cc80150ab53f83307b50a747a03 354 SUPERFAMILY SSF82689 214 307 1.96E-9 T 09-03-2017 IPR011066 Mechanosensitive ion channel MscS, C-terminal GO:0016020 TK78_RS24165 fac83cc80150ab53f83307b50a747a03 354 Pfam PF00924 Mechanosensitive ion channel 108 307 3.9E-35 T 09-03-2017 IPR006685 Mechanosensitive ion channel MscS GO:0016020|GO:0055085 TK78_RS24165 fac83cc80150ab53f83307b50a747a03 354 SUPERFAMILY SSF82861 87 148 4.45E-9 T 09-03-2017 IPR011014 Mechanosensitive ion channel MscS, transmembrane-2 GO:0016020 TK78_RS24165 fac83cc80150ab53f83307b50a747a03 354 Gene3D G3DSA:2.30.30.60 165 209 3.3E-10 T 09-03-2017 TK78_RS24165 fac83cc80150ab53f83307b50a747a03 354 Gene3D G3DSA:3.30.70.100 221 305 6.0E-5 T 09-03-2017 TK78_RS24165 fac83cc80150ab53f83307b50a747a03 354 SUPERFAMILY SSF50182 150 207 1.44E-9 T 09-03-2017 IPR010920 LSM domain TK78_RS25325 658cad64f1a208c74627c29ec7388d42 340 TIGRFAM TIGR03638 cas1_ECOLI: CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI 11 276 8.7E-105 T 09-03-2017 IPR019851 CRISPR-associated protein Cas1, ECOLI subtype GO:0004520|GO:0043571|GO:0046872 TK78_RS25325 658cad64f1a208c74627c29ec7388d42 340 Pfam PF01867 CRISPR associated protein Cas1 27 123 1.9E-6 T 09-03-2017 IPR002729 CRISPR-associated protein Cas1 GO:0003676|GO:0004519|GO:0043571|GO:0046872|GO:0051607 TK78_RS25325 658cad64f1a208c74627c29ec7388d42 340 Pfam PF01867 CRISPR associated protein Cas1 137 250 3.3E-8 T 09-03-2017 IPR002729 CRISPR-associated protein Cas1 GO:0003676|GO:0004519|GO:0043571|GO:0046872|GO:0051607 TK78_RS25325 658cad64f1a208c74627c29ec7388d42 340 TIGRFAM TIGR00287 cas1: CRISPR-associated endonuclease Cas1 135 252 8.4E-23 T 09-03-2017 IPR002729 CRISPR-associated protein Cas1 GO:0003676|GO:0004519|GO:0043571|GO:0046872|GO:0051607 TK78_RS25325 658cad64f1a208c74627c29ec7388d42 340 Hamap MF_01470 CRISPR-associated endonuclease Cas1 [cas1]. 7 277 17.577 T 09-03-2017 IPR002729 CRISPR-associated protein Cas1 GO:0003676|GO:0004519|GO:0043571|GO:0046872|GO:0051607 TK78_RS29485 726ca652e4fb26fa6dd0daa817c00cb4 145 Pfam PF14108 Domain of unknown function (DUF4281) 5 129 1.2E-27 T 09-03-2017 IPR025461 ABA DEFICIENT 4-like TK78_RS02920 5b430b4b22ff20e6a352913fdae90f75 75 SUPERFAMILY SSF88659 7 67 4.11E-13 T 09-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS02920 5b430b4b22ff20e6a352913fdae90f75 75 Gene3D G3DSA:1.10.10.10 11 68 4.6E-17 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS02920 5b430b4b22ff20e6a352913fdae90f75 75 Pfam PF08281 Sigma-70, region 4 11 62 4.0E-13 T 09-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TK78_RS17555 ccb4e52abe02508d2f1c6292127e1054 116 SUPERFAMILY SSF46785 13 109 2.22E-27 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS17555 ccb4e52abe02508d2f1c6292127e1054 116 Gene3D G3DSA:1.10.10.10 7 109 3.5E-31 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS17555 ccb4e52abe02508d2f1c6292127e1054 116 Pfam PF01638 HxlR-like helix-turn-helix 23 110 2.0E-24 T 09-03-2017 IPR002577 Helix-turn-helix, HxlR type TK78_RS24235 7d24f169bdc52b0a637be8ea416c7d1c 864 SUPERFAMILY SSF63737 10 205 1.2E-34 T 09-03-2017 TK78_RS24235 7d24f169bdc52b0a637be8ea416c7d1c 864 TIGRFAM TIGR02412 pepN_strep_liv: aminopeptidase N 5 858 0.0 T 09-03-2017 IPR012778 Peptidase M1, aminopeptidase GO:0004177|GO:0006508 KEGG: 00480+3.4.11.2|MetaCyc: PWY-4061|MetaCyc: PWY-6842|MetaCyc: PWY-7112 TK78_RS24235 7d24f169bdc52b0a637be8ea416c7d1c 864 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 310 325 1.6E-18 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS24235 7d24f169bdc52b0a637be8ea416c7d1c 864 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 188 203 1.6E-18 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS24235 7d24f169bdc52b0a637be8ea416c7d1c 864 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 276 286 1.6E-18 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS24235 7d24f169bdc52b0a637be8ea416c7d1c 864 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 145 160 1.6E-18 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS24235 7d24f169bdc52b0a637be8ea416c7d1c 864 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 329 341 1.6E-18 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS24235 7d24f169bdc52b0a637be8ea416c7d1c 864 Pfam PF11838 ERAP1-like C-terminal domain 541 852 5.2E-62 T 09-03-2017 IPR024571 ERAP1-like C-terminal domain TK78_RS24235 7d24f169bdc52b0a637be8ea416c7d1c 864 Gene3D G3DSA:1.10.390.10 323 468 2.7E-40 T 09-03-2017 TK78_RS24235 7d24f169bdc52b0a637be8ea416c7d1c 864 SUPERFAMILY SSF55486 223 468 2.2E-73 T 09-03-2017 TK78_RS24235 7d24f169bdc52b0a637be8ea416c7d1c 864 Pfam PF01433 Peptidase family M1 112 402 1.2E-63 T 09-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 TK78_RS10100 614d3d551c6511886ff0e28a954b3d8b 496 Pfam PF01740 STAS domain 408 479 6.5E-8 T 09-03-2017 IPR002645 STAS domain TK78_RS10100 614d3d551c6511886ff0e28a954b3d8b 496 Gene3D G3DSA:3.30.750.24 403 483 1.3E-9 T 09-03-2017 IPR002645 STAS domain TK78_RS10100 614d3d551c6511886ff0e28a954b3d8b 496 SUPERFAMILY SSF52091 403 484 1.45E-12 T 09-03-2017 IPR002645 STAS domain TK78_RS10100 614d3d551c6511886ff0e28a954b3d8b 496 Pfam PF00916 Sulfate permease family 171 364 4.5E-27 T 09-03-2017 IPR011547 SLC26A/SulP transporter domain GO:0008272|GO:0015116|GO:0016021 TK78_RS10100 614d3d551c6511886ff0e28a954b3d8b 496 Pfam PF00916 Sulfate permease family 23 147 9.8E-21 T 09-03-2017 IPR011547 SLC26A/SulP transporter domain GO:0008272|GO:0015116|GO:0016021 TK78_RS25855 3ddde66fe65101a99f423d5a5891c317 590 Pfam PF00668 Condensation domain 50 314 4.2E-23 T 09-03-2017 IPR001242 Condensation domain TK78_RS25855 3ddde66fe65101a99f423d5a5891c317 590 SUPERFAMILY SSF52777 217 459 1.45E-19 T 09-03-2017 TK78_RS25855 3ddde66fe65101a99f423d5a5891c317 590 SUPERFAMILY SSF52777 48 210 7.26E-21 T 09-03-2017 TK78_RS00695 d2b336cd31fe4e4f737a5f91818cd6f0 312 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 138 300 6.7E-14 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS00695 d2b336cd31fe4e4f737a5f91818cd6f0 312 Gene3D G3DSA:1.10.3720.10 32 300 4.1E-53 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS00695 d2b336cd31fe4e4f737a5f91818cd6f0 312 SUPERFAMILY SSF161098 39 312 1.44E-54 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS19740 12298f5643656c9fb895c3831a072a8f 387 Pfam PF01212 Beta-eliminating lyase 56 285 5.1E-23 T 09-03-2017 IPR001597 Aromatic amino acid beta-eliminating lyase/threonine aldolase GO:0006520|GO:0016829 Reactome: R-HSA-6783984 TK78_RS19740 12298f5643656c9fb895c3831a072a8f 387 SUPERFAMILY SSF53383 55 316 8.64E-57 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS19740 12298f5643656c9fb895c3831a072a8f 387 Gene3D G3DSA:3.40.640.10 61 253 3.7E-31 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS00530 018f3447abea1e708bdaf089a721cc81 218 Pfam PF09335 SNARE associated Golgi protein 43 171 4.2E-22 T 09-03-2017 IPR032816 SNARE associated Golgi protein TK78_RS04935 7569610d2dc79e0c3ecc92e3369ebef4 1630 Pfam PF12770 CHAT domain 1345 1629 1.9E-46 T 09-03-2017 IPR024983 CHAT domain TK78_RS04935 7569610d2dc79e0c3ecc92e3369ebef4 1630 Gene3D G3DSA:1.25.40.10 368 421 1.6E-4 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS04935 7569610d2dc79e0c3ecc92e3369ebef4 1630 Gene3D G3DSA:1.25.40.10 495 530 1.6E-4 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS04935 7569610d2dc79e0c3ecc92e3369ebef4 1630 Gene3D G3DSA:1.25.40.10 585 619 1.6E-4 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS04935 7569610d2dc79e0c3ecc92e3369ebef4 1630 Gene3D G3DSA:1.25.40.10 761 828 1.6E-4 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS24815 efd30744a5f1e47543067c4301a27a60 165 Hamap MF_00009 Endoribonuclease YbeY [ybeY]. 2 160 21.635 T 09-03-2017 IPR002036 Endoribonuclease YbeY GO:0004222|GO:0006364 TK78_RS24815 efd30744a5f1e47543067c4301a27a60 165 Pfam PF02130 Uncharacterized protein family UPF0054 16 147 1.5E-36 T 09-03-2017 IPR002036 Endoribonuclease YbeY GO:0004222|GO:0006364 TK78_RS24815 efd30744a5f1e47543067c4301a27a60 165 Gene3D G3DSA:3.40.390.30 5 156 1.4E-42 T 09-03-2017 IPR023091 Metalloprotease catalytic domain, predicted GO:0004222 TK78_RS24815 efd30744a5f1e47543067c4301a27a60 165 TIGRFAM TIGR00043 TIGR00043: rRNA maturation RNase YbeY 36 148 2.4E-31 T 09-03-2017 IPR002036 Endoribonuclease YbeY GO:0004222|GO:0006364 TK78_RS24815 efd30744a5f1e47543067c4301a27a60 165 SUPERFAMILY SSF55486 3 148 9.28E-37 T 09-03-2017 TK78_RS24815 efd30744a5f1e47543067c4301a27a60 165 ProSitePatterns PS01306 Uncharacterized protein family UPF0054 signature. 119 129 - T 09-03-2017 IPR020549 Endoribonuclease YbeY, conserved site TK78_RS25750 ffc810ea4b43576de7002815444920f9 364 SUPERFAMILY SSF47090 285 354 3.14E-11 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS25750 ffc810ea4b43576de7002815444920f9 364 Pfam PF01471 Putative peptidoglycan binding domain 296 354 1.9E-7 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS25750 ffc810ea4b43576de7002815444920f9 364 Gene3D G3DSA:1.10.101.10 286 357 2.5E-12 T 09-03-2017 IPR002477 Peptidoglycan binding-like TK78_RS17350 26f6359d83dcc1cfeec326dd2a8301f8 119 TIGRFAM TIGR00278 TIGR00278: putative membrane protein insertion efficiency factor 5 73 1.1E-26 T 09-03-2017 IPR002696 Putative membrane protein insertion efficiency factor TK78_RS17350 26f6359d83dcc1cfeec326dd2a8301f8 119 Pfam PF01809 Haemolytic domain 5 68 1.1E-27 T 09-03-2017 IPR002696 Putative membrane protein insertion efficiency factor TK78_RS17350 26f6359d83dcc1cfeec326dd2a8301f8 119 Hamap MF_00386 Putative membrane protein insertion efficiency factor [yidD]. 1 69 24.158 T 09-03-2017 IPR002696 Putative membrane protein insertion efficiency factor TK78_RS17350 26f6359d83dcc1cfeec326dd2a8301f8 119 ProDom PD004225 UPF0161 ALPHA-HEMOLYSIN YIDD UNCHARACTERIZED CYTOSOLIC PRECURSOR SIGNAL YTJA RNPA SIMILAR 16 68 7.0E-24 T 09-03-2017 IPR002696 Putative membrane protein insertion efficiency factor TK78_RS17350 26f6359d83dcc1cfeec326dd2a8301f8 119 SMART SM01234 1 68 1.3E-42 T 09-03-2017 IPR002696 Putative membrane protein insertion efficiency factor TK78_RS33945 87ef3399d02e269c42fc7ea5a7ce7344 270 Gene3D G3DSA:3.10.180.10 148 264 1.3E-16 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS33945 87ef3399d02e269c42fc7ea5a7ce7344 270 Gene3D G3DSA:3.10.180.10 21 132 1.3E-21 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS33945 87ef3399d02e269c42fc7ea5a7ce7344 270 SUPERFAMILY SSF54593 13 135 2.2E-13 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS33945 87ef3399d02e269c42fc7ea5a7ce7344 270 SUPERFAMILY SSF54593 148 264 2.82E-11 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS31595 51ad0aaa19ade6a9f403c7e543b924dc 94 TIGRFAM TIGR01552 phd_fam: prevent-host-death family protein 4 54 3.3E-16 T 09-03-2017 IPR006442 Type II toxin-antitoxin system, antitoxin Phd/YefM TK78_RS31595 51ad0aaa19ade6a9f403c7e543b924dc 94 Pfam PF02604 Antitoxin Phd_YefM, type II toxin-antitoxin system 5 57 2.2E-14 T 09-03-2017 IPR006442 Type II toxin-antitoxin system, antitoxin Phd/YefM TK78_RS31595 51ad0aaa19ade6a9f403c7e543b924dc 94 Gene3D G3DSA:3.40.1620.10 3 51 7.4E-14 T 09-03-2017 IPR006442 Type II toxin-antitoxin system, antitoxin Phd/YefM TK78_RS31595 51ad0aaa19ade6a9f403c7e543b924dc 94 SUPERFAMILY SSF143120 5 52 3.4E-11 T 09-03-2017 TK78_RS02905 48fef23b439b43cc1779818bee7ebe2c 167 SMART SM00507 11 63 7.1E-10 T 09-03-2017 IPR003615 HNH nuclease TK78_RS02905 48fef23b439b43cc1779818bee7ebe2c 167 Pfam PF01844 HNH endonuclease 24 68 6.0E-13 T 09-03-2017 IPR002711 HNH endonuclease GO:0003676|GO:0004519 TK78_RS01965 253e693d8d8b6c5fd0e70810cc18df27 426 Pfam PF00953 Glycosyl transferase family 4 81 216 6.8E-14 T 09-03-2017 IPR000715 Glycosyl transferase, family 4 GO:0008963|GO:0016021 KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471|Reactome: R-HSA-446193|Reactome: R-HSA-4549356 TK78_RS23815 0dcfbdab13eb412a9d04ee0973f6789f 113 Pfam PF12647 RNHCP domain 5 93 1.1E-31 T 09-03-2017 IPR024439 RNHCP domain TK78_RS30170 cc1a3b4b06e6de583fd31eabc4ccf887 229 Gene3D G3DSA:3.60.15.10 9 219 5.6E-50 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS30170 cc1a3b4b06e6de583fd31eabc4ccf887 229 SUPERFAMILY SSF56281 6 219 5.55E-47 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS30170 cc1a3b4b06e6de583fd31eabc4ccf887 229 SMART SM00849 12 202 4.7E-37 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS30170 cc1a3b4b06e6de583fd31eabc4ccf887 229 Pfam PF00753 Metallo-beta-lactamase superfamily 9 202 6.5E-29 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS07420 491d684cf411a803c91be1e7f39a9889 101 Pfam PF14013 MT0933-like antitoxin protein 16 63 3.4E-17 T 09-03-2017 IPR028037 Antitoxin Rv0909/MT0933 TK78_RS04005 73645af734bc51b766959c20df53f2d8 295 SUPERFAMILY SSF53335 34 222 2.15E-30 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS04005 73645af734bc51b766959c20df53f2d8 295 Pfam PF13649 Methyltransferase domain 56 152 1.3E-13 T 09-03-2017 TK78_RS04005 73645af734bc51b766959c20df53f2d8 295 Gene3D G3DSA:3.40.50.150 36 223 4.5E-27 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS31810 e73d3b2a63ef7f6440fdac96797408a6 342 TIGRFAM TIGR01728 SsuA_fam: ABC transporter, substrate-binding protein, aliphatic sulfonates family 41 323 2.3E-61 T 09-03-2017 IPR010067 Aliphatic sulfonates-binding protein GO:0006790|GO:0006810|GO:0016020 TK78_RS31810 e73d3b2a63ef7f6440fdac96797408a6 342 SUPERFAMILY SSF53850 42 267 1.09E-43 T 09-03-2017 TK78_RS31810 e73d3b2a63ef7f6440fdac96797408a6 342 SMART SM00062 39 253 4.9E-9 T 09-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF TK78_RS31810 e73d3b2a63ef7f6440fdac96797408a6 342 Gene3D G3DSA:3.40.190.10 247 264 2.5E-26 T 09-03-2017 TK78_RS31810 e73d3b2a63ef7f6440fdac96797408a6 342 Gene3D G3DSA:3.40.190.10 118 214 2.5E-26 T 09-03-2017 TK78_RS31810 e73d3b2a63ef7f6440fdac96797408a6 342 Pfam PF09084 NMT1/THI5 like 78 256 3.3E-11 T 09-03-2017 IPR015168 SsuA/THI5-like TK78_RS14945 b8f48be1c21fd3e25fb77754f896a3d5 374 Pfam PF04188 Mannosyltransferase (PIG-V) 44 191 1.1E-9 T 09-03-2017 IPR007315 GPI mannosyltransferase 2 GO:0004584|GO:0006506 Reactome: R-HSA-162710 TK78_RS01430 62b2aff38275181dc9a8163dcc8b9344 59 Gene3D G3DSA:1.10.1470.10 5 58 1.5E-7 T 09-03-2017 IPR008462 CsbD-like TK78_RS01365 0e4b0fd5de818b680aaf40e367fc8b03 359 Gene3D G3DSA:3.40.50.720 1 211 3.4E-23 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS01365 0e4b0fd5de818b680aaf40e367fc8b03 359 Pfam PF01113 Dihydrodipicolinate reductase, N-terminus 5 67 1.9E-6 T 09-03-2017 IPR000846 Dihydrodipicolinate reductase, N-terminal GO:0008839|GO:0009089|GO:0055114 KEGG: 00261+1.17.1.8|KEGG: 00300+1.17.1.8|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TK78_RS01365 0e4b0fd5de818b680aaf40e367fc8b03 359 SUPERFAMILY SSF51735 2 142 2.56E-8 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS29435 aa1bd48a05526735faa67c057788d611 145 Pfam PF03779 SPW repeat 40 84 6.7E-16 T 09-03-2017 IPR005530 SPW repeat TK78_RS29435 aa1bd48a05526735faa67c057788d611 145 Pfam PF03779 SPW repeat 92 138 3.9E-15 T 09-03-2017 IPR005530 SPW repeat TK78_RS09940 bb687d3229175781c0529da359ad43ae 411 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 3 25 3.2E-5 T 09-03-2017 TK78_RS09940 bb687d3229175781c0529da359ad43ae 411 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 302 318 3.2E-5 T 09-03-2017 TK78_RS09940 bb687d3229175781c0529da359ad43ae 411 Gene3D G3DSA:3.50.50.60 3 167 5.3E-10 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS09940 bb687d3229175781c0529da359ad43ae 411 Gene3D G3DSA:3.50.50.60 274 356 5.3E-10 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS09940 bb687d3229175781c0529da359ad43ae 411 SUPERFAMILY SSF51905 282 357 4.92E-19 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS09940 bb687d3229175781c0529da359ad43ae 411 SUPERFAMILY SSF51905 2 157 4.92E-19 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS03565 5e3774ae31f893414c24fa88f6b17773 195 SUPERFAMILY SSF55729 18 180 1.17E-33 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS03565 5e3774ae31f893414c24fa88f6b17773 195 Gene3D G3DSA:3.40.630.30 18 186 3.2E-37 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS03565 5e3774ae31f893414c24fa88f6b17773 195 Pfam PF13302 Acetyltransferase (GNAT) domain 24 155 4.1E-19 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS00210 f240014cf9a15a6e6efae7b92fcd79ff 69 Pfam PF13359 DDE superfamily endonuclease 2 64 4.7E-7 T 09-03-2017 IPR027806 Harbinger transposase-derived nuclease domain TK78_RS19600 8c2131cd638e36f37d0ae6127175af52 239 Pfam PF09335 SNARE associated Golgi protein 41 168 4.4E-25 T 09-03-2017 IPR032816 SNARE associated Golgi protein TK78_RS16395 b4addd71f8b915c0ed04647a36511797 361 Pfam PF01757 Acyltransferase family 31 329 4.3E-17 T 09-03-2017 IPR002656 Acyltransferase 3 GO:0016747 TK78_RS02980 4767743fb2c493a1a06eb717d8cdcd55 287 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 98 272 2.1E-32 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS02980 4767743fb2c493a1a06eb717d8cdcd55 287 SUPERFAMILY SSF161098 78 261 9.42E-35 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS02980 4767743fb2c493a1a06eb717d8cdcd55 287 Gene3D G3DSA:1.10.3720.10 78 271 1.9E-27 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS15110 94ed34c7b451f0fee9d4eef40c2f91bc 311 SUPERFAMILY SSF52540 196 288 2.03E-13 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15110 94ed34c7b451f0fee9d4eef40c2f91bc 311 SUPERFAMILY SSF52540 9 50 2.03E-13 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15110 94ed34c7b451f0fee9d4eef40c2f91bc 311 SUPERFAMILY SSF52540 84 169 2.03E-13 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15110 94ed34c7b451f0fee9d4eef40c2f91bc 311 Gene3D G3DSA:3.40.50.300 12 43 2.5E-34 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS15110 94ed34c7b451f0fee9d4eef40c2f91bc 311 Gene3D G3DSA:3.40.50.300 87 273 2.5E-34 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01585 d1fe0c5d48270f48d5c0ccd25a4d7db0 230 SUPERFAMILY SSF55961 5 151 1.84E-8 T 09-03-2017 TK78_RS33195 adbeb37c6a23b29c39a3fe37bd314606 138 Gene3D G3DSA:3.10.129.10 2 129 8.2E-33 T 09-03-2017 IPR029069 HotDog domain TK78_RS33195 adbeb37c6a23b29c39a3fe37bd314606 138 SUPERFAMILY SSF54637 1 130 7.14E-34 T 09-03-2017 IPR029069 HotDog domain TK78_RS33195 adbeb37c6a23b29c39a3fe37bd314606 138 Pfam PF13279 Thioesterase-like superfamily 13 120 1.4E-17 T 09-03-2017 TK78_RS31430 fcde697906fefe3f11734db25884a0f9 562 Pfam PF05960 Bacterial protein of unknown function (DUF885) 26 557 1.4E-143 T 09-03-2017 IPR010281 Protein of unknown function DUF885 TK78_RS21385 40d8b64fe66e8e6cf1c33774907cf713 174 Pfam PF14431 YwqJ-like deaminase 34 157 3.5E-25 T 09-03-2017 IPR025968 YwqJ-like deaminase TK78_RS05705 8d4fd0338544616b320957d02e70ddc8 520 Pfam PF07690 Major Facilitator Superfamily 25 413 3.4E-47 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS05705 8d4fd0338544616b320957d02e70ddc8 520 SUPERFAMILY SSF103473 251 422 4.32E-62 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS05705 8d4fd0338544616b320957d02e70ddc8 520 SUPERFAMILY SSF103473 6 204 4.32E-62 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS05705 8d4fd0338544616b320957d02e70ddc8 520 SUPERFAMILY SSF103473 474 498 4.32E-62 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS05705 8d4fd0338544616b320957d02e70ddc8 520 Gene3D G3DSA:1.20.1250.20 470 497 3.8E-17 T 09-03-2017 TK78_RS05705 8d4fd0338544616b320957d02e70ddc8 520 Gene3D G3DSA:1.20.1250.20 268 420 3.8E-17 T 09-03-2017 TK78_RS05705 8d4fd0338544616b320957d02e70ddc8 520 Gene3D G3DSA:1.20.1250.20 18 197 1.1E-25 T 09-03-2017 TK78_RS23345 0064873729416711b11f8b6c25bf09d2 197 SUPERFAMILY SSF48150 8 187 4.54E-67 T 09-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 TK78_RS23345 0064873729416711b11f8b6c25bf09d2 197 Pfam PF03352 Methyladenine glycosylase 12 184 6.0E-64 T 09-03-2017 IPR005019 Methyladenine glycosylase GO:0006284|GO:0008725 TK78_RS23345 0064873729416711b11f8b6c25bf09d2 197 Gene3D G3DSA:1.10.340.30 8 185 2.3E-71 T 09-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 TK78_RS04680 0e86aa1e8d8f7092d68d8007817eef62 427 Gene3D G3DSA:3.40.640.10 59 308 8.5E-66 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS04680 0e86aa1e8d8f7092d68d8007817eef62 427 Gene3D G3DSA:3.90.1150.10 309 425 1.3E-36 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS04680 0e86aa1e8d8f7092d68d8007817eef62 427 Pfam PF00202 Aminotransferase class-III 24 423 4.4E-86 T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS04680 0e86aa1e8d8f7092d68d8007817eef62 427 SUPERFAMILY SSF53383 15 423 5.77E-104 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS16275 e0698f1e208a57473983f6a5d91bbb3b 370 SUPERFAMILY SSF51395 7 358 8.31E-93 T 09-03-2017 TK78_RS16275 e0698f1e208a57473983f6a5d91bbb3b 370 Pfam PF00724 NADH:flavin oxidoreductase / NADH oxidase family 13 355 8.4E-57 T 09-03-2017 IPR001155 NADH:flavin oxidoreductase/NADH oxidase, N-terminal GO:0010181|GO:0016491|GO:0055114 TK78_RS16275 e0698f1e208a57473983f6a5d91bbb3b 370 Gene3D G3DSA:3.20.20.70 7 360 4.5E-100 T 09-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 TK78_RS15950 3bce5843d410644a429da011e59bd54a 445 Pfam PF07730 Histidine kinase 216 280 1.5E-18 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS15950 3bce5843d410644a429da011e59bd54a 445 SUPERFAMILY SSF55874 299 414 6.69E-10 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS30245 f543709b061e4dfc70383000cb597bb6 601 Pfam PF02618 YceG-like family 292 592 7.0E-64 T 09-03-2017 IPR003770 Uncharacterised protein family UPF0755, YceG-like TK78_RS30245 f543709b061e4dfc70383000cb597bb6 601 TIGRFAM TIGR00247 TIGR00247: conserved hypothetical protein, YceG family 254 594 8.8E-48 T 09-03-2017 IPR003770 Uncharacterised protein family UPF0755, YceG-like TK78_RS02570 d404b81429f0953e4080f52e27eb0f0c 394 TIGRFAM TIGR03886 lyase_spl_fam: spore photoproduct lyase family protein 49 394 4.6E-177 T 09-03-2017 IPR023805 Uncharacterised protein family, spore photo-product lyase-related TK78_RS08470 e6c38f3199d71fb4da3285d3fabc466d 67 Pfam PF13822 Acyl-CoA carboxylase epsilon subunit 9 65 1.9E-17 T 09-03-2017 IPR032716 Acyl-CoA carboxylase epsilon subunit TK78_RS25425 27c688b4d92fb89d2380ab1c04eea384 273 Pfam PF07264 Etoposide-induced protein 2.4 (EI24) 10 229 3.5E-31 T 09-03-2017 TK78_RS34120 9028c7fb856f2ce3385b598839725df6 213 SUPERFAMILY SSF56112 5 147 1.04E-30 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS34120 9028c7fb856f2ce3385b598839725df6 213 Gene3D G3DSA:1.10.510.10 5 149 1.1E-26 T 09-03-2017 TK78_RS34120 9028c7fb856f2ce3385b598839725df6 213 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 20 32 - T 09-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 TK78_RS34120 9028c7fb856f2ce3385b598839725df6 213 Pfam PF00069 Protein kinase domain 8 145 5.2E-18 T 09-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 TK78_RS17055 90767bca0a78cc09897161e74513bc9b 300 Pfam PF00296 Luciferase-like monooxygenase 22 239 1.0E-44 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS17055 90767bca0a78cc09897161e74513bc9b 300 SUPERFAMILY SSF51679 20 292 4.84E-55 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS17055 90767bca0a78cc09897161e74513bc9b 300 Gene3D G3DSA:3.20.20.30 21 294 8.5E-61 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS20670 16951dfd03f74e89bbc9b4e9de6447b4 265 Pfam PF14243 Domain of unknown function (DUF4343) 114 242 1.9E-36 T 09-03-2017 IPR025643 Protein of unknown function DUF4343 TK78_RS12865 6fab39e7b2bdc5722e4f66261f4ffd8c 129 Pfam PF04343 Protein of unknown function, DUF488 11 122 6.2E-29 T 09-03-2017 IPR007438 Protein of unknown function DUF488 TK78_RS26830 43ad6eae9a9f1705c4b359c748b128a2 341 Gene3D G3DSA:3.90.1720.10 223 340 8.5E-42 T 09-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain TK78_RS26830 43ad6eae9a9f1705c4b359c748b128a2 341 Pfam PF00877 NlpC/P60 family 242 338 2.1E-24 T 09-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain TK78_RS26830 43ad6eae9a9f1705c4b359c748b128a2 341 SUPERFAMILY SSF54001 224 340 1.13E-37 T 09-03-2017 TK78_RS09110 f26f029bf287fff137dedfb33d6dbd5f 487 PIRSF PIRSF006060 3 431 2.2E-51 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS09110 f26f029bf287fff137dedfb33d6dbd5f 487 Pfam PF13520 Amino acid permease 22 427 6.3E-63 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS09110 f26f029bf287fff137dedfb33d6dbd5f 487 TIGRFAM TIGR00905 2A0302: transporter, basic amino acid/polyamine antiporter (APA) family 19 486 6.5E-150 T 09-03-2017 IPR004754 Amino acid antiporter GO:0006865|GO:0016021 TK78_RS08255 89f8bc794121049d006415b05e40e5f7 138 Gene3D G3DSA:1.10.10.10 21 133 1.0E-38 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS08255 89f8bc794121049d006415b05e40e5f7 138 Pfam PF01638 HxlR-like helix-turn-helix 36 118 8.0E-22 T 09-03-2017 IPR002577 Helix-turn-helix, HxlR type TK78_RS08255 89f8bc794121049d006415b05e40e5f7 138 SUPERFAMILY SSF46785 20 125 6.57E-29 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS24665 d20b0f2eb43b8c68c22765a59f5ca90e 153 Gene3D G3DSA:2.30.110.10 10 149 2.7E-37 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS24665 d20b0f2eb43b8c68c22765a59f5ca90e 153 SUPERFAMILY SSF50475 11 136 1.52E-21 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS24665 d20b0f2eb43b8c68c22765a59f5ca90e 153 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 26 97 3.9E-7 T 09-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS26090 be9089e0db9bcb12c3f842f8ceb5bada 555 SUPERFAMILY SSF56300 179 525 6.92E-29 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS26090 be9089e0db9bcb12c3f842f8ceb5bada 555 Pfam PF09423 PhoD-like phosphatase 183 524 2.9E-104 T 09-03-2017 IPR018946 Alkaline phosphatase D-related TK78_RS26090 be9089e0db9bcb12c3f842f8ceb5bada 555 Gene3D G3DSA:3.60.21.10 192 527 2.6E-13 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS26090 be9089e0db9bcb12c3f842f8ceb5bada 555 Pfam PF16655 PhoD-like phosphatase, N-terminal domain 74 170 1.2E-30 T 09-03-2017 IPR032093 Phospholipase D, N-terminal TK78_RS21545 f651420ca68e362e768d52725023730f 217 Pfam PF13624 SurA N-terminal domain 8 149 1.3E-10 T 09-03-2017 TK78_RS21545 f651420ca68e362e768d52725023730f 217 SUPERFAMILY SSF109998 32 165 6.28E-13 T 09-03-2017 IPR027304 Trigger factor/SurA domain TK78_RS25100 2bd1c252ae2c6905e67a16fa7e619e1d 296 SMART SM00530 29 101 0.0016 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS25100 2bd1c252ae2c6905e67a16fa7e619e1d 296 Pfam PF13560 Helix-turn-helix domain 25 104 9.4E-15 T 09-03-2017 TK78_RS25100 2bd1c252ae2c6905e67a16fa7e619e1d 296 Gene3D G3DSA:1.10.260.40 23 100 2.3E-12 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS04015 ba8d97f721ca2d84d3017bd3209b9b44 296 SUPERFAMILY SSF51735 24 279 5.88E-33 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS04015 ba8d97f721ca2d84d3017bd3209b9b44 296 Gene3D G3DSA:3.40.50.720 23 225 2.6E-21 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS23410 023880fa3b9afa91e01e951e3659f1fc 304 Pfam PF08021 Siderophore-interacting FAD-binding domain 20 141 1.3E-32 T 09-03-2017 IPR013113 FAD-binding 9, siderophore-interacting TK78_RS23410 023880fa3b9afa91e01e951e3659f1fc 304 Gene3D G3DSA:2.40.30.10 12 140 1.3E-31 T 09-03-2017 TK78_RS23410 023880fa3b9afa91e01e951e3659f1fc 304 Gene3D G3DSA:3.40.50.80 150 276 7.0E-41 T 09-03-2017 TK78_RS23410 023880fa3b9afa91e01e951e3659f1fc 304 Pfam PF04954 Siderophore-interacting protein 156 270 1.0E-32 T 09-03-2017 IPR007037 Siderophore-interacting protein TK78_RS23410 023880fa3b9afa91e01e951e3659f1fc 304 SUPERFAMILY SSF63380 12 141 5.67E-10 T 09-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 TK78_RS12980 92b520b9cbbb6de9c1a3ff8f96df16c4 321 TIGRFAM TIGR00271 TIGR00271: uncharacterized hydrophobic domain 112 295 3.3E-52 T 09-03-2017 TK78_RS12980 92b520b9cbbb6de9c1a3ff8f96df16c4 321 Pfam PF04087 Domain of unknown function (DUF389) 145 289 1.8E-27 T 09-03-2017 IPR005240 Protein of unknown function DUF389 TK78_RS11355 437c94f69ac752af98a3c3ce67ede9e3 466 PIRSF PIRSF006060 2 451 3.2E-52 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS11355 437c94f69ac752af98a3c3ce67ede9e3 466 Pfam PF13520 Amino acid permease 39 423 1.2E-31 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS08090 07fb02c09eedf5fb29769a819f6c5ed8 238 SUPERFAMILY SSF51261 77 192 2.14E-13 T 09-03-2017 IPR011055 Duplicated hybrid motif TK78_RS08090 07fb02c09eedf5fb29769a819f6c5ed8 238 Gene3D G3DSA:2.70.70.10 56 193 1.2E-21 T 09-03-2017 TK78_RS08090 07fb02c09eedf5fb29769a819f6c5ed8 238 Pfam PF01551 Peptidase family M23 91 188 3.1E-12 T 09-03-2017 IPR016047 Peptidase M23 TK78_RS13980 635f3139d69e597a3e4b6a7db6eae76a 167 Pfam PF13581 Histidine kinase-like ATPase domain 13 128 8.7E-7 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS02235 1ec425254b272f124df271da44dbea85 254 Pfam PF14023 Protein of unknown function (DUF4239) 48 235 7.0E-23 T 09-03-2017 IPR025333 Protein of unknown function DUF4239 TK78_RS20235 bdcac2117c81f74d44c20279e34d132e 200 Gene3D G3DSA:3.40.30.10 9 199 1.6E-44 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS20235 bdcac2117c81f74d44c20279e34d132e 200 ProSitePatterns PS00194 Thioredoxin family active site. 84 102 - T 09-03-2017 IPR017937 Thioredoxin, conserved site GO:0045454 TK78_RS20235 bdcac2117c81f74d44c20279e34d132e 200 Pfam PF00578 AhpC/TSA family 59 178 1.8E-24 T 09-03-2017 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15|Reactome: R-HSA-3299685 TK78_RS20235 bdcac2117c81f74d44c20279e34d132e 200 SUPERFAMILY SSF52833 59 199 3.25E-34 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS30415 6bbbc86c46cd35f9309322394be7d5c4 564 Gene3D G3DSA:3.50.50.60 304 362 6.3E-8 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS30415 6bbbc86c46cd35f9309322394be7d5c4 564 Gene3D G3DSA:3.50.50.60 502 542 6.3E-8 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS30415 6bbbc86c46cd35f9309322394be7d5c4 564 Pfam PF01593 Flavin containing amine oxidoreductase 59 533 3.8E-47 T 09-03-2017 IPR002937 Amine oxidase GO:0016491|GO:0055114 TK78_RS30415 6bbbc86c46cd35f9309322394be7d5c4 564 SUPERFAMILY SSF54373 362 477 2.49E-28 T 09-03-2017 TK78_RS30415 6bbbc86c46cd35f9309322394be7d5c4 564 SUPERFAMILY SSF51905 49 377 3.7E-43 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS30415 6bbbc86c46cd35f9309322394be7d5c4 564 SUPERFAMILY SSF51905 466 539 3.7E-43 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS30415 6bbbc86c46cd35f9309322394be7d5c4 564 Gene3D G3DSA:3.90.660.10 366 468 3.7E-27 T 09-03-2017 TK78_RS30415 6bbbc86c46cd35f9309322394be7d5c4 564 Gene3D G3DSA:3.90.660.10 81 154 3.7E-27 T 09-03-2017 TK78_RS30415 6bbbc86c46cd35f9309322394be7d5c4 564 Gene3D G3DSA:3.40.50.720 48 80 3.1E-11 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS14850 e6c04dec68dbb0dcea3795345936d22a 117 SUPERFAMILY SSF50346 17 112 2.01E-20 T 09-03-2017 IPR011033 PRC-barrel-like TK78_RS08410 ce54d489dcf92420b515a5b477daf893 239 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 145 161 2.2E-8 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS08410 ce54d489dcf92420b515a5b477daf893 239 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 3 14 2.2E-8 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS08410 ce54d489dcf92420b515a5b477daf893 239 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 163 183 2.2E-8 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS08410 ce54d489dcf92420b515a5b477daf893 239 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 114 127 2.2E-8 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS08410 ce54d489dcf92420b515a5b477daf893 239 SUPERFAMILY SSF56784 2 226 2.0E-41 T 09-03-2017 IPR023214 HAD-like domain TK78_RS08410 ce54d489dcf92420b515a5b477daf893 239 Gene3D G3DSA:3.40.50.1000 1 224 4.9E-39 T 09-03-2017 IPR023214 HAD-like domain TK78_RS08410 ce54d489dcf92420b515a5b477daf893 239 Pfam PF13419 Haloacid dehalogenase-like hydrolase 7 201 4.9E-18 T 09-03-2017 IPR023214 HAD-like domain TK78_RS08410 ce54d489dcf92420b515a5b477daf893 239 TIGRFAM TIGR01549 HAD-SF-IA-v1: HAD hydrolase, family IA, variant 1 95 196 1.2E-12 T 09-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 TK78_RS04075 3eead33e08e3da62113d325d9c7dc312 258 Gene3D G3DSA:3.60.15.10 1 253 9.6E-55 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS04075 3eead33e08e3da62113d325d9c7dc312 258 Pfam PF12706 Beta-lactamase superfamily domain 19 207 1.2E-31 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS04075 3eead33e08e3da62113d325d9c7dc312 258 SUPERFAMILY SSF56281 102 214 8.4E-28 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS04075 3eead33e08e3da62113d325d9c7dc312 258 SUPERFAMILY SSF56281 2 72 8.4E-28 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS32605 0685bfb8e667d2f6a5725be4eba38c5d 381 SUPERFAMILY SSF53067 151 350 7.54E-37 T 09-03-2017 TK78_RS32605 0685bfb8e667d2f6a5725be4eba38c5d 381 Pfam PF01869 BadF/BadG/BcrA/BcrD ATPase family 14 305 1.7E-14 T 09-03-2017 IPR002731 ATPase, BadF/BadG/BcrA/BcrD type Reactome: R-HSA-446210 TK78_RS34595 f6061b45ec52bb4c6d6137ff9286a999 165 Pfam PF00932 Lamin Tail Domain 31 149 2.9E-16 T 09-03-2017 IPR001322 Lamin Tail Domain TK78_RS34595 f6061b45ec52bb4c6d6137ff9286a999 165 Gene3D G3DSA:2.60.40.1260 26 150 1.6E-11 T 09-03-2017 IPR001322 Lamin Tail Domain TK78_RS34595 f6061b45ec52bb4c6d6137ff9286a999 165 SUPERFAMILY SSF74853 55 149 1.06E-14 T 09-03-2017 IPR001322 Lamin Tail Domain TK78_RS19305 e0a839ef889503bdd3e2bfa8a1622fa8 296 Pfam PF13349 Putative adhesin 20 227 1.5E-11 T 09-03-2017 IPR025164 Putative adhesin TK78_RS27960 9e8a6b0dddb0f8ce1e9858e59634f374 328 Pfam PF02628 Cytochrome oxidase assembly protein 75 295 4.4E-14 T 09-03-2017 IPR003780 COX15/CtaA family GO:0006784|GO:0016021|GO:0016627|GO:0055114 Reactome: R-HSA-189451 TK78_RS27960 9e8a6b0dddb0f8ce1e9858e59634f374 328 Pfam PF02628 Cytochrome oxidase assembly protein 26 68 3.1E-9 T 09-03-2017 IPR003780 COX15/CtaA family GO:0006784|GO:0016021|GO:0016627|GO:0055114 Reactome: R-HSA-189451 TK78_RS03825 018753bf9662f2012dfab6f9ad0a547e 129 Hamap MF_01661 D-ribose pyranase [rbsD]. 1 129 29.542 T 09-03-2017 IPR023064 D-ribose pyranase GO:0016872 TK78_RS03825 018753bf9662f2012dfab6f9ad0a547e 129 Pfam PF05025 RbsD / FucU transport protein family 2 127 3.5E-40 T 09-03-2017 IPR007721 D-ribose pyranase RbsD/L-fucose mutarotase FucU GO:0005996|GO:0016853|GO:0048029 Reactome: R-HSA-6787639 TK78_RS03825 018753bf9662f2012dfab6f9ad0a547e 129 SUPERFAMILY SSF102546 2 129 1.03E-37 T 09-03-2017 IPR023750 RbsD-like domain GO:0005996|GO:0016853|GO:0048029 Reactome: R-HSA-6787639 TK78_RS03825 018753bf9662f2012dfab6f9ad0a547e 129 Gene3D G3DSA:3.40.1650.10 2 129 3.5E-27 T 09-03-2017 IPR023750 RbsD-like domain GO:0005996|GO:0016853|GO:0048029 Reactome: R-HSA-6787639 TK78_RS10540 bd66a7c7cc3687754553b3acb2f18199 251 SUPERFAMILY SSF51219 17 226 1.83E-41 T 09-03-2017 IPR016031 Tryptophan RNA-binding attenuator protein-like domain TK78_RS10540 bd66a7c7cc3687754553b3acb2f18199 251 Pfam PF01987 Mitochondrial biogenesis AIM24 21 215 1.3E-28 T 09-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 TK78_RS10540 bd66a7c7cc3687754553b3acb2f18199 251 Gene3D G3DSA:3.60.160.10 20 222 1.2E-33 T 09-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 TK78_RS14785 71161ae903d46893fb2532a86294a327 240 Gene3D G3DSA:1.10.3210.10 52 178 4.3E-11 T 09-03-2017 IPR006674 HD domain TK78_RS14785 71161ae903d46893fb2532a86294a327 240 PIRSF PIRSF035170 18 237 2.3E-76 T 09-03-2017 IPR009218 Predicted HD phosphohydrolase TK78_RS14785 71161ae903d46893fb2532a86294a327 240 SUPERFAMILY SSF109604 49 233 2.06E-30 T 09-03-2017 TK78_RS29475 7867f5a1e43c56eafe07adb0af80e9f9 250 Pfam PF13490 Putative zinc-finger 11 37 1.0E-5 T 09-03-2017 IPR027383 Putative zinc-finger TK78_RS29475 7867f5a1e43c56eafe07adb0af80e9f9 250 Pfam PF10099 Anti-sigma-K factor rskA 58 243 2.2E-34 T 09-03-2017 IPR018764 Anti-sigma K factor RskA GO:0005886|GO:0016021 TK78_RS11595 98a9e5b8cc026211e0a3770a87b84342 202 Pfam PF13400 Putative Flp pilus-assembly TadE/G-like 10 56 6.7E-7 T 09-03-2017 IPR028087 Putative Flp pilus-assembly TadG-like, N-terminal TK78_RS21445 c64156af7654722e45d67205a6ed4f88 174 Pfam PF13581 Histidine kinase-like ATPase domain 43 151 1.2E-11 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS21445 c64156af7654722e45d67205a6ed4f88 174 SUPERFAMILY SSF55874 70 163 6.02E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS00870 2377a4c3c4a262f39bc48791de33e6dc 206 SUPERFAMILY SSF109854 83 201 4.76E-8 T 09-03-2017 TK78_RS00870 2377a4c3c4a262f39bc48791de33e6dc 206 Pfam PF12867 DinB superfamily 41 194 8.2E-10 T 09-03-2017 IPR024775 DinB-like domain TK78_RS06720 98b5966b561af443dba8b3687f14141b 160 Pfam PF14102 Capsule biosynthesis CapC 17 133 2.0E-31 T 09-03-2017 IPR008338 Capsule biosynthesis protein CapC GO:0016020|GO:0045227 TK78_RS09190 48a01e0fd763435e2983f77a4523c41c 653 Pfam PF04865 Baseplate J-like protein 386 565 3.1E-15 T 09-03-2017 IPR006949 Baseplate protein J-like TK78_RS09190 48a01e0fd763435e2983f77a4523c41c 653 TIGRFAM TIGR02243 TIGR02243: putative baseplate assembly protein 7 611 8.1E-162 T 09-03-2017 IPR011749 Conserved hypothetical protein CHP02243 TK78_RS18345 f74b5bb95bdc563c9e62a38780c749a6 554 SUPERFAMILY SSF56300 283 473 3.14E-29 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS18345 f74b5bb95bdc563c9e62a38780c749a6 554 Pfam PF00149 Calcineurin-like phosphoesterase 288 454 1.1E-14 T 09-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 TK78_RS18345 f74b5bb95bdc563c9e62a38780c749a6 554 Gene3D G3DSA:3.60.21.10 287 454 3.8E-18 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS07775 7661a0f45ab73766c7eeae40cd3dd617 186 SUPERFAMILY SSF53597 3 183 1.27E-22 T 09-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 TK78_RS07775 7661a0f45ab73766c7eeae40cd3dd617 186 Gene3D G3DSA:3.40.430.10 3 185 6.2E-23 T 09-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 TK78_RS07775 7661a0f45ab73766c7eeae40cd3dd617 186 Pfam PF01872 RibD C-terminal domain 3 173 9.8E-19 T 09-03-2017 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 TK78_RS03280 8e0192d9f84f982023c90484be194a65 600 Pfam PF02028 BCCT, betaine/carnitine/choline family transporter 36 526 7.1E-175 T 09-03-2017 IPR000060 BCCT transporter family GO:0005215|GO:0006810|GO:0016020 TK78_RS03280 8e0192d9f84f982023c90484be194a65 600 TIGRFAM TIGR00842 bcct: transporter, betaine/carnitine/choline transporter (BCCT) family 74 526 1.6E-157 T 09-03-2017 IPR000060 BCCT transporter family GO:0005215|GO:0006810|GO:0016020 TK78_RS03280 8e0192d9f84f982023c90484be194a65 600 ProSitePatterns PS01303 BCCT family of transporters signature. 343 352 - T 09-03-2017 IPR018093 BCCT transporter, conserved site GO:0005215|GO:0006810|GO:0016020 TK78_RS11750 914eb0dfe5ca0183b5ea4727428957b3 431 Pfam PF05816 Toxic anion resistance protein (TelA) 99 417 7.3E-82 T 09-03-2017 IPR008863 Toxic anion resistance TK78_RS34165 91fe217e3efd4624cb2a39e7b15dd60c 737 Gene3D G3DSA:1.10.600.10 5 324 5.4E-111 T 09-03-2017 IPR008949 Isoprenoid synthase domain TK78_RS34165 91fe217e3efd4624cb2a39e7b15dd60c 737 Gene3D G3DSA:1.10.600.10 361 701 1.4E-97 T 09-03-2017 IPR008949 Isoprenoid synthase domain TK78_RS34165 91fe217e3efd4624cb2a39e7b15dd60c 737 SUPERFAMILY SSF48576 3 331 5.18E-70 T 09-03-2017 IPR008949 Isoprenoid synthase domain TK78_RS34165 91fe217e3efd4624cb2a39e7b15dd60c 737 SUPERFAMILY SSF48576 374 694 4.03E-65 T 09-03-2017 IPR008949 Isoprenoid synthase domain TK78_RS30520 63acebb213f3f49d6e4056161ae341a5 500 Pfam PF03929 PepSY-associated TM region 56 432 7.5E-57 T 09-03-2017 IPR005625 PepSY-associated TM protein TK78_RS03835 5dec548a78648309ccc4de7fb2eddb3b 651 SUPERFAMILY SSF53822 355 650 7.07E-91 T 09-03-2017 IPR028082 Periplasmic binding protein-like I TK78_RS03835 5dec548a78648309ccc4de7fb2eddb3b 651 Pfam PF02653 Branched-chain amino acid transport system / permease component 51 314 8.0E-47 T 09-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 TK78_RS03835 5dec548a78648309ccc4de7fb2eddb3b 651 Pfam PF13407 Periplasmic binding protein domain 377 629 2.9E-64 T 09-03-2017 IPR025997 Periplasmic binding protein TK78_RS03835 5dec548a78648309ccc4de7fb2eddb3b 651 Gene3D G3DSA:3.40.50.2300 374 492 1.6E-41 T 09-03-2017 TK78_RS03835 5dec548a78648309ccc4de7fb2eddb3b 651 Gene3D G3DSA:3.40.50.2300 493 650 5.5E-58 T 09-03-2017 TK78_RS24300 4cb35ce97fee44fc5aa76ab11146a890 243 SUPERFAMILY SSF160104 14 172 1.31E-6 T 09-03-2017 TK78_RS24300 4cb35ce97fee44fc5aa76ab11146a890 243 Pfam PF09844 Uncharacterized conserved protein (COG2071) 12 150 8.0E-11 T 09-03-2017 IPR018644 Protein of unknown function DUF2071 TK78_RS20750 555daec6faab3489bc2522b04e359ca7 50 Pfam PF13340 Putative transposase of IS4/5 family (DUF4096) 1 46 5.4E-9 T 09-03-2017 IPR025161 Putative transposase IS4/IS5 family TK78_RS23910 3641e2fc6edabbac098c02324e8916f4 259 SUPERFAMILY SSF53335 30 232 2.13E-43 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS23910 3641e2fc6edabbac098c02324e8916f4 259 Pfam PF13649 Methyltransferase domain 70 169 2.2E-19 T 09-03-2017 TK78_RS23910 3641e2fc6edabbac098c02324e8916f4 259 Gene3D G3DSA:3.40.50.150 46 245 1.2E-39 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS28410 00ad422f620addcf74fb18e952c16fa2 464 Pfam PF01523 Putative modulator of DNA gyrase 25 325 7.3E-33 T 09-03-2017 IPR002510 Metalloprotease TldD/PmbA GO:0006508|GO:0008237 TK78_RS28410 00ad422f620addcf74fb18e952c16fa2 464 SUPERFAMILY SSF111283 9 457 3.01E-65 T 09-03-2017 TK78_RS23430 26cb37d65a2dd12f43dc1a09d7df3c77 180 Pfam PF08044 Domain of unknown function (DUF1707) 10 62 4.0E-15 T 09-03-2017 IPR012551 Protein of unknown function DUF1707 TK78_RS33150 c764d1cb22bcb3b6d792ef5311b18320 350 Pfam PF02653 Branched-chain amino acid transport system / permease component 74 337 1.2E-45 T 09-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 TK78_RS03270 245d0bbb8657538b4a5a1b00c8986a25 398 Pfam PF16483 Beta-1,3-glucanase 37 394 1.7E-104 T 09-03-2017 IPR032477 Beta-1,3-glucanase, N-terminal KEGG: 00500+3.2.1.39 TK78_RS31250 28f22f1b64666416e77c6a4a76b97ac8 337 Pfam PF01794 Ferric reductase like transmembrane component 107 234 1.9E-11 T 09-03-2017 IPR013130 Ferric reductase transmembrane component-like domain TK78_RS22650 c5141f3fb9d28223f80a3c0a4b0ff1b0 419 Pfam PF02378 Phosphotransferase system, EIIC 26 338 3.4E-68 T 09-03-2017 IPR003352 Phosphotransferase system, EIIC GO:0008982|GO:0009401|GO:0016020 TK78_RS33635 f0cb19f4927ec6c77e8532db71dd15b5 253 Gene3D G3DSA:3.90.550.10 22 198 1.3E-17 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS33635 f0cb19f4927ec6c77e8532db71dd15b5 253 SUPERFAMILY SSF53448 8 226 3.64E-37 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS33635 f0cb19f4927ec6c77e8532db71dd15b5 253 Pfam PF00535 Glycosyl transferase family 2 23 139 2.4E-18 T 09-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 TK78_RS15780 a5d5f40c1e63bd918ee8ea748568073c 180 Pfam PF03780 Asp23 family, cell envelope-related function 52 162 3.9E-31 T 09-03-2017 IPR005531 Alkaline shock protein Asp23 TK78_RS24110 e14604ccf8a1874d1373d7ffba2b3651 483 SMART SM00332 202 467 5.9E-10 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS24110 e14604ccf8a1874d1373d7ffba2b3651 483 Pfam PF13672 Protein phosphatase 2C 224 430 2.7E-14 T 09-03-2017 TK78_RS24110 e14604ccf8a1874d1373d7ffba2b3651 483 SUPERFAMILY SSF81606 212 468 4.58E-38 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS24110 e14604ccf8a1874d1373d7ffba2b3651 483 Gene3D G3DSA:3.60.40.10 212 468 6.7E-50 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS24110 e14604ccf8a1874d1373d7ffba2b3651 483 SMART SM00331 216 469 4.1E-4 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS30860 8be8806c5020349ea0b0836bbf6cfeaa 189 SUPERFAMILY SSF109854 5 41 2.65E-17 T 09-03-2017 TK78_RS30860 8be8806c5020349ea0b0836bbf6cfeaa 189 SUPERFAMILY SSF109854 78 178 2.65E-17 T 09-03-2017 TK78_RS30860 8be8806c5020349ea0b0836bbf6cfeaa 189 Pfam PF12867 DinB superfamily 11 171 4.5E-20 T 09-03-2017 IPR024775 DinB-like domain TK78_RS30860 8be8806c5020349ea0b0836bbf6cfeaa 189 Gene3D G3DSA:1.20.120.450 106 177 2.5E-5 T 09-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase TK78_RS23905 b064c91c817df7e5bc88328ddfd6bc13 780 Gene3D G3DSA:1.20.1640.10 142 347 7.5E-29 T 09-03-2017 TK78_RS23905 b064c91c817df7e5bc88328ddfd6bc13 780 Gene3D G3DSA:1.20.1640.10 508 728 4.8E-27 T 09-03-2017 TK78_RS23905 b064c91c817df7e5bc88328ddfd6bc13 780 SUPERFAMILY SSF82866 494 724 5.1E-25 T 09-03-2017 TK78_RS23905 b064c91c817df7e5bc88328ddfd6bc13 780 SUPERFAMILY SSF82866 155 345 3.27E-29 T 09-03-2017 TK78_RS23905 b064c91c817df7e5bc88328ddfd6bc13 780 Pfam PF03176 MMPL family 492 727 1.0E-34 T 09-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 TK78_RS23905 b064c91c817df7e5bc88328ddfd6bc13 780 Pfam PF03176 MMPL family 54 401 8.4E-46 T 09-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 TK78_RS22735 1cc352a350f3f7d67ef6ee24b4958476 233 Pfam PF08044 Domain of unknown function (DUF1707) 1 53 6.1E-25 T 09-03-2017 IPR012551 Protein of unknown function DUF1707 TK78_RS17680 8c1bf71b8a8151e499abc4bfe59c1c34 261 SMART SM00382 51 238 1.0E-13 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS17680 8c1bf71b8a8151e499abc4bfe59c1c34 261 Gene3D G3DSA:3.40.50.300 21 242 5.5E-68 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17680 8c1bf71b8a8151e499abc4bfe59c1c34 261 Pfam PF00005 ABC transporter 42 190 4.1E-32 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS17680 8c1bf71b8a8151e499abc4bfe59c1c34 261 SUPERFAMILY SSF52540 22 243 4.26E-65 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS17680 8c1bf71b8a8151e499abc4bfe59c1c34 261 ProSitePatterns PS00211 ABC transporters family signature. 163 177 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS01550 5b511919864810872c504ab4adc67e2a 199 Pfam PF01381 Helix-turn-helix 22 76 5.3E-14 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS01550 5b511919864810872c504ab4adc67e2a 199 Gene3D G3DSA:2.60.120.10 106 186 9.3E-14 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS01550 5b511919864810872c504ab4adc67e2a 199 SMART SM00530 21 76 1.4E-16 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS01550 5b511919864810872c504ab4adc67e2a 199 SUPERFAMILY SSF51182 84 182 1.6E-19 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS01550 5b511919864810872c504ab4adc67e2a 199 Pfam PF07883 Cupin domain 117 183 9.1E-13 T 09-03-2017 IPR013096 Cupin 2, conserved barrel TK78_RS01550 5b511919864810872c504ab4adc67e2a 199 SUPERFAMILY SSF47413 14 81 1.46E-17 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS01550 5b511919864810872c504ab4adc67e2a 199 Gene3D G3DSA:1.10.260.40 15 88 4.7E-20 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS11615 474e4881f3f601f1c5d974d29f294e29 295 Pfam PF00482 Type II secretion system (T2SS), protein F 152 277 1.1E-20 T 09-03-2017 IPR018076 Type II secretion system F domain TK78_RS29240 e29263b64a04c389ab00705490ea3f1c 196 TIGRFAM TIGR03847 TIGR03847: conserved hypothetical protein 5 190 1.5E-78 T 09-03-2017 IPR021441 Protein of unknown function DUF3090 TK78_RS29240 e29263b64a04c389ab00705490ea3f1c 196 Pfam PF11290 Protein of unknown function (DUF3090) 7 186 1.2E-67 T 09-03-2017 IPR021441 Protein of unknown function DUF3090 TK78_RS30750 b0c71dcfa5e9ca4f6a4da720705c5cd6 202 PIRSF PIRSF000847 11 202 6.7E-42 T 09-03-2017 IPR004570 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase GO:0008444|GO:0008654|GO:0016021 KEGG: 00564+2.7.8.5|MetaCyc: PWY-5269|MetaCyc: PWY-5668 TK78_RS30750 b0c71dcfa5e9ca4f6a4da720705c5cd6 202 Pfam PF01066 CDP-alcohol phosphatidyltransferase 16 85 5.3E-15 T 09-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 TK78_RS30750 b0c71dcfa5e9ca4f6a4da720705c5cd6 202 ProSitePatterns PS00379 CDP-alcohol phosphatidyltransferases signature. 63 85 - T 09-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 TK78_RS02700 e2c1f3cfb97f053b3dccaeb6cfc82ff6 291 Pfam PF14378 PAP2 superfamily 56 235 1.5E-41 T 09-03-2017 IPR026841 Inositolphosphotransferase Aur1/Ipt1 TK78_RS31940 bcc2b24346e79b5c09d6d8bd50c77470 150 Pfam PF02575 YbaB/EbfC DNA-binding family 13 100 3.9E-10 T 09-03-2017 IPR004401 Nucleoid-associated protein YbaB/EbfC family TK78_RS31940 bcc2b24346e79b5c09d6d8bd50c77470 150 SUPERFAMILY SSF82607 13 101 1.96E-6 T 09-03-2017 IPR004401 Nucleoid-associated protein YbaB/EbfC family TK78_RS31940 bcc2b24346e79b5c09d6d8bd50c77470 150 Gene3D G3DSA:3.30.1310.10 8 106 3.0E-6 T 09-03-2017 IPR004401 Nucleoid-associated protein YbaB/EbfC family TK78_RS28660 3acf58b1e08bb76e1a615b339bd7c551 345 Pfam PF02616 Segregation and condensation protein ScpA 95 316 6.8E-51 T 09-03-2017 IPR003768 Segregation and condensation protein A TK78_RS01115 bc587ea131ea247f8756a9db42b75927 186 Pfam PF11361 Protein of unknown function (DUF3159) 1 179 3.9E-57 T 09-03-2017 IPR016566 Uncharacterised conserved protein UCP010219 TK78_RS02650 4c7e6061ce43b26c74faf17ad4e5605d 180 Pfam PF14325 Domain of unknown function (DUF4383) 18 132 2.2E-15 T 09-03-2017 IPR025492 Protein of unknown function DUF4383 TK78_RS34505 377561a438cacd5e9b31f66dee1b1fcd 124 SUPERFAMILY SSF54593 1 110 3.1E-16 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS34505 377561a438cacd5e9b31f66dee1b1fcd 124 Gene3D G3DSA:3.10.180.10 1 119 3.8E-14 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS22730 20b14b0916f82bb038e7dc1dca8e8789 328 Gene3D G3DSA:3.40.50.300 4 245 1.1E-60 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22730 20b14b0916f82bb038e7dc1dca8e8789 328 SMART SM00382 44 229 4.2E-11 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS22730 20b14b0916f82bb038e7dc1dca8e8789 328 SUPERFAMILY SSF52540 30 243 1.67E-54 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS22730 20b14b0916f82bb038e7dc1dca8e8789 328 Pfam PF00005 ABC transporter 36 179 1.2E-24 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS30855 5a58623f8350d5f53e0c20277c39abfe 372 SUPERFAMILY SSF143990 233 363 9.15E-25 T 09-03-2017 TK78_RS30855 5a58623f8350d5f53e0c20277c39abfe 372 Pfam PF08719 Domain of unknown function (DUF1768) 250 362 8.8E-13 T 09-03-2017 IPR012816 NADAR TK78_RS09300 c3e0d062d686ff02ba32a47ee5cd912b 189 SUPERFAMILY SSF48317 5 179 1.09E-31 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS09300 c3e0d062d686ff02ba32a47ee5cd912b 189 Gene3D G3DSA:1.20.144.10 11 178 4.6E-31 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS09300 c3e0d062d686ff02ba32a47ee5cd912b 189 SMART SM00014 65 177 9.1E-16 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS09300 c3e0d062d686ff02ba32a47ee5cd912b 189 Pfam PF01569 PAP2 superfamily 73 177 1.7E-17 T 09-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TK78_RS22680 ea6688ea6687cf1a257e7ff50502f49c 235 Pfam PF13392 HNH endonuclease 174 204 1.2E-5 T 09-03-2017 IPR003615 HNH nuclease TK78_RS28725 4f23cf78b1ec2fe7b4ec7bffff0b3008 361 SUPERFAMILY SSF48179 165 258 3.97E-21 T 09-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 TK78_RS28725 4f23cf78b1ec2fe7b4ec7bffff0b3008 361 Gene3D G3DSA:3.40.50.720 4 171 7.2E-26 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS28725 4f23cf78b1ec2fe7b4ec7bffff0b3008 361 Pfam PF02153 Prephenate dehydrogenase 18 250 1.9E-56 T 09-03-2017 IPR003099 Prephenate dehydrogenase GO:0004665|GO:0006571|GO:0008977|GO:0055114 KEGG: 00400+1.3.1.12|KEGG: 00401+1.3.1.12|MetaCyc: PWY-7303 TK78_RS28725 4f23cf78b1ec2fe7b4ec7bffff0b3008 361 SUPERFAMILY SSF51735 5 158 2.09E-26 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS17475 a7605c5601b510bea38d2cd593a68082 84 Hamap MF_00631 Cell division protein CrgA [crgA]. 1 84 23.263 T 09-03-2017 IPR009619 Cell division protein CrgA TK78_RS17475 a7605c5601b510bea38d2cd593a68082 84 Pfam PF06781 Uncharacterised protein family (UPF0233) 2 84 5.2E-29 T 09-03-2017 IPR009619 Cell division protein CrgA TK78_RS30725 ae12f07ce81a152022f051bcb8be55a2 149 Pfam PF00358 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 3 124 1.5E-38 T 09-03-2017 IPR001127 Phosphotransferase system, sugar-specific permease EIIA type 1 GO:0009401 TK78_RS30725 ae12f07ce81a152022f051bcb8be55a2 149 SUPERFAMILY SSF51261 3 146 1.74E-36 T 09-03-2017 IPR011055 Duplicated hybrid motif TK78_RS30725 ae12f07ce81a152022f051bcb8be55a2 149 Gene3D G3DSA:2.70.70.10 3 148 5.6E-45 T 09-03-2017 TK78_RS18295 188ed25c7a92e6d4ba082823037fd3ee 68 SUPERFAMILY SSF46955 11 59 2.61E-11 T 09-03-2017 IPR009061 Putative DNA-binding domain TK78_RS18295 188ed25c7a92e6d4ba082823037fd3ee 68 TIGRFAM TIGR01764 excise: DNA binding domain, excisionase family 11 58 1.2E-8 T 09-03-2017 IPR010093 SinI-like, DNA-binding domain GO:0003677 TK78_RS18295 188ed25c7a92e6d4ba082823037fd3ee 68 Pfam PF12728 Helix-turn-helix domain 11 59 1.3E-11 T 09-03-2017 TK78_RS18295 188ed25c7a92e6d4ba082823037fd3ee 68 Gene3D G3DSA:1.10.1660.10 11 57 5.4E-7 T 09-03-2017 TK78_RS02955 5a437248bbd16259e9c4b8b0549a8f70 242 Pfam PF01261 Xylose isomerase-like TIM barrel 18 197 6.4E-12 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS02955 5a437248bbd16259e9c4b8b0549a8f70 242 SUPERFAMILY SSF51658 4 240 2.32E-34 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS02955 5a437248bbd16259e9c4b8b0549a8f70 242 Gene3D G3DSA:3.20.20.150 3 241 3.3E-49 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS23595 7305e6050ec8b45309a5b9d7a8d58e44 378 Pfam PF13699 Domain of unknown function (DUF4157) 42 113 3.7E-25 T 09-03-2017 IPR025295 Domain of unknown function DUF4157 TK78_RS15625 d11fd8f2a6b0e25e05631791e034be96 294 Pfam PF00941 FAD binding domain in molybdopterin dehydrogenase 23 169 1.1E-18 T 09-03-2017 IPR002346 Molybdopterin dehydrogenase, FAD-binding GO:0016491|GO:0055114 TK78_RS15625 d11fd8f2a6b0e25e05631791e034be96 294 Gene3D G3DSA:3.30.465.10 56 169 3.8E-23 T 09-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 TK78_RS15625 d11fd8f2a6b0e25e05631791e034be96 294 SUPERFAMILY SSF56176 18 169 2.45E-27 T 09-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 TK78_RS15625 d11fd8f2a6b0e25e05631791e034be96 294 SUPERFAMILY SSF55447 222 271 9.42E-5 T 09-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal TK78_RS06360 30f16ff37e64b70ccc578e03e0504cd4 206 Pfam PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 7 106 1.6E-22 T 09-03-2017 IPR001133 NADH-ubiquinone oxidoreductase chain 4L/K GO:0016651|GO:0042773|GO:0055114 TK78_RS06955 7ce304c88bf9b798710947fa5ec3ee93 365 Pfam PF11268 Protein of unknown function (DUF3071) 1 168 7.4E-55 T 09-03-2017 IPR021421 Protein of unknown function DUF3071 TK78_RS03850 2bfe52b07e1f67f26c91645fc87ad6cc 297 Gene3D G3DSA:3.40.50.300 54 109 2.2E-8 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03850 2bfe52b07e1f67f26c91645fc87ad6cc 297 Gene3D G3DSA:3.40.50.300 145 171 2.2E-8 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS03850 2bfe52b07e1f67f26c91645fc87ad6cc 297 Pfam PF13086 AAA domain 53 93 1.9E-6 T 09-03-2017 TK78_RS15225 adb95b9bbf55897cd3e964c2f1ea50f7 87 Pfam PF00872 Transposase, Mutator family 10 76 3.5E-10 T 09-03-2017 IPR001207 Transposase, mutator type GO:0003677|GO:0004803|GO:0006313 TK78_RS19510 95a56b9ab4967bff425f19f51d6dac37 708 Pfam PF13515 Fusaric acid resistance protein-like 385 505 1.3E-18 T 09-03-2017 TK78_RS09590 cbda52b8b8882a22ac779126f5eec48b 346 SUPERFAMILY SSF51679 1 345 1.13E-70 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS09590 cbda52b8b8882a22ac779126f5eec48b 346 Pfam PF00296 Luciferase-like monooxygenase 1 315 1.6E-53 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS09590 cbda52b8b8882a22ac779126f5eec48b 346 Gene3D G3DSA:3.20.20.30 1 345 2.3E-88 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS17115 0452d02c6c22fd0ce7e4f2fc6337e51b 450 Pfam PF07907 YibE/F-like protein 181 418 9.3E-74 T 09-03-2017 IPR012507 YibE/F-like TK78_RS26690 61414ba05102e7456d62a070aee03764 199 Pfam PF11241 Protein of unknown function (DUF3043) 30 197 1.4E-62 T 09-03-2017 IPR021403 Protein of unknown function DUF3043 TK78_RS17910 e4d9b8b72df981f22d532b44ae1f34ca 219 Gene3D G3DSA:3.40.50.360 4 185 7.6E-39 T 09-03-2017 IPR029039 Flavoprotein-like domain TK78_RS17910 e4d9b8b72df981f22d532b44ae1f34ca 219 TIGRFAM TIGR04037 LLM_duo_CE1759: LLM-partnered FMN reductase, CE1759 family 9 213 4.8E-84 T 09-03-2017 IPR023932 Uncharacterised protein family, CE1759 TK78_RS17910 e4d9b8b72df981f22d532b44ae1f34ca 219 Pfam PF03358 NADPH-dependent FMN reductase 8 160 5.7E-38 T 09-03-2017 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 TK78_RS17910 e4d9b8b72df981f22d532b44ae1f34ca 219 SUPERFAMILY SSF52218 4 185 5.87E-33 T 09-03-2017 IPR029039 Flavoprotein-like domain TK78_RS18840 e90a5e6150cb3cf41c70f0c860897545 230 Pfam PF11209 Protein of unknown function (DUF2993) 21 220 1.1E-29 T 09-03-2017 IPR021373 Protein of unknown function DUF2993 TK78_RS20135 36f5b46e07ac55e94037393113470d13 397 Pfam PF01139 tRNA-splicing ligase RtcB 29 397 4.9E-130 T 09-03-2017 IPR001233 tRNA-splicing ligase, RtcB GO:0006396|GO:0008452 Reactome: R-HSA-6784531 TK78_RS20135 36f5b46e07ac55e94037393113470d13 397 SUPERFAMILY SSF103365 11 397 1.44E-129 T 09-03-2017 IPR001233 tRNA-splicing ligase, RtcB GO:0006396|GO:0008452 Reactome: R-HSA-6784531 TK78_RS00035 e1b6d3f00e284e37267bcd26868044d9 426 Pfam PF03457 Helicase associated domain 354 416 2.7E-7 T 09-03-2017 IPR005114 Helicase-associated TK78_RS00035 e1b6d3f00e284e37267bcd26868044d9 426 Pfam PF03457 Helicase associated domain 131 193 5.5E-17 T 09-03-2017 IPR005114 Helicase-associated TK78_RS00035 e1b6d3f00e284e37267bcd26868044d9 426 Pfam PF03457 Helicase associated domain 268 329 1.8E-7 T 09-03-2017 IPR005114 Helicase-associated TK78_RS19765 da8fe053f9f47c602c89c44e9b44532d 265 SUPERFAMILY SSF53067 129 261 2.85E-36 T 09-03-2017 TK78_RS19765 da8fe053f9f47c602c89c44e9b44532d 265 Hamap MF_01274 Type III pantothenate kinase [coaX]. 1 262 36.145 T 09-03-2017 IPR004619 Type III pantothenate kinase GO:0004594 KEGG: 00770+2.7.1.33|MetaCyc: PWY-3961 TK78_RS19765 da8fe053f9f47c602c89c44e9b44532d 265 TIGRFAM TIGR00671 baf: pantothenate kinase, type III 2 258 2.5E-77 T 09-03-2017 IPR004619 Type III pantothenate kinase GO:0004594 KEGG: 00770+2.7.1.33|MetaCyc: PWY-3961 TK78_RS19765 da8fe053f9f47c602c89c44e9b44532d 265 SUPERFAMILY SSF53067 1 127 4.09E-33 T 09-03-2017 TK78_RS19765 da8fe053f9f47c602c89c44e9b44532d 265 Gene3D G3DSA:3.30.420.40 1 68 5.0E-5 T 09-03-2017 TK78_RS19765 da8fe053f9f47c602c89c44e9b44532d 265 Pfam PF03309 Type III pantothenate kinase 2 210 2.8E-69 T 09-03-2017 IPR004619 Type III pantothenate kinase GO:0004594 KEGG: 00770+2.7.1.33|MetaCyc: PWY-3961 TK78_RS19765 da8fe053f9f47c602c89c44e9b44532d 265 Gene3D G3DSA:3.30.420.40 99 263 2.8E-51 T 09-03-2017 TK78_RS07590 26ea4aaa581b228222ea2cf854fc23c8 266 Pfam PF13413 Helix-turn-helix domain 18 78 3.6E-21 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS07590 26ea4aaa581b228222ea2cf854fc23c8 266 Pfam PF13464 Domain of unknown function (DUF4115) 186 257 2.2E-17 T 09-03-2017 IPR025194 Domain of unknown function DUF4115 TK78_RS07590 26ea4aaa581b228222ea2cf854fc23c8 266 Gene3D G3DSA:1.10.260.40 7 83 6.1E-6 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS19675 7caad98117eb94f88add6cd828b1d743 596 Pfam PF16995 Transmembrane region of lysyl-tRNA synthetase 14 213 6.7E-14 T 09-03-2017 IPR031553 Lysyl-tRNA synthetase, N-terminal transmembrane region KEGG: 00970+6.1.1.6 TK78_RS19675 7caad98117eb94f88add6cd828b1d743 596 Pfam PF09924 Uncharacterised conserved protein (DUF2156) 237 545 4.6E-101 T 09-03-2017 IPR024320 Phosphatidylglycerol lysyltransferase, C-terminal TK78_RS20330 afcc2a45b6cfd5f1482256dc6d2d605c 364 Pfam PF02310 B12 binding domain 105 214 7.6E-16 T 09-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 TK78_RS20330 afcc2a45b6cfd5f1482256dc6d2d605c 364 Gene3D G3DSA:3.40.50.280 102 219 9.0E-20 T 09-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 TK78_RS20330 afcc2a45b6cfd5f1482256dc6d2d605c 364 Pfam PF02607 B12 binding domain 22 91 5.0E-14 T 09-03-2017 IPR003759 Cobalamin (vitamin B12)-binding module, cap domain Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TK78_RS20330 afcc2a45b6cfd5f1482256dc6d2d605c 364 SUPERFAMILY SSF52242 101 237 3.92E-20 T 09-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 TK78_RS26135 4bbccc9e26187385a0b9a6684e26c920 279 Gene3D G3DSA:3.40.50.300 20 254 8.0E-61 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS26135 4bbccc9e26187385a0b9a6684e26c920 279 SUPERFAMILY SSF52540 14 249 3.89E-60 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS26135 4bbccc9e26187385a0b9a6684e26c920 279 Pfam PF00005 ABC transporter 41 188 5.3E-30 T 09-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TK78_RS26135 4bbccc9e26187385a0b9a6684e26c920 279 ProSitePatterns PS00211 ABC transporters family signature. 160 174 - T 09-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TK78_RS26135 4bbccc9e26187385a0b9a6684e26c920 279 SMART SM00382 50 236 2.6E-17 T 09-03-2017 IPR003593 AAA+ ATPase domain TK78_RS06445 3190c3560969f2a3b8e28e81daec99b0 328 Gene3D G3DSA:3.20.20.330 8 307 4.7E-86 T 09-03-2017 IPR003726 Homocysteine-binding domain Reactome: R-HSA-1614635 TK78_RS06445 3190c3560969f2a3b8e28e81daec99b0 328 SUPERFAMILY SSF82282 9 307 5.89E-78 T 09-03-2017 IPR003726 Homocysteine-binding domain Reactome: R-HSA-1614635 TK78_RS06445 3190c3560969f2a3b8e28e81daec99b0 328 Pfam PF02574 Homocysteine S-methyltransferase 19 302 5.0E-64 T 09-03-2017 IPR003726 Homocysteine-binding domain Reactome: R-HSA-1614635 TK78_RS25975 adf4344cf424b6946ea77c24fe20bf06 447 Gene3D G3DSA:2.130.10.10 77 281 6.3E-6 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS00065 93f49a48d0014cf1120d0e35a741ef37 428 Gene3D G3DSA:3.40.50.300 188 245 2.0E-11 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS00065 93f49a48d0014cf1120d0e35a741ef37 428 SUPERFAMILY SSF52540 184 345 1.95E-15 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23045 f1fc9ec653142b683735acb6e58dc097 196 SUPERFAMILY SSF81296 28 196 3.5E-62 T 09-03-2017 IPR014756 Immunoglobulin E-set TK78_RS23045 f1fc9ec653142b683735acb6e58dc097 196 Gene3D G3DSA:2.70.50.50 28 196 2.6E-67 T 09-03-2017 TK78_RS23045 f1fc9ec653142b683735acb6e58dc097 196 Pfam PF03067 Lytic polysaccharide mono-oxygenase, cellulose-degrading 28 194 1.7E-43 T 09-03-2017 IPR004302 Chitin-binding protein, N-terminal TK78_RS12545 ba312212f943ecbd99ba590686ae76b4 374 SUPERFAMILY SSF52540 70 354 2.77E-22 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS12545 ba312212f943ecbd99ba590686ae76b4 374 Pfam PF07728 AAA domain (dynein-related subfamily) 92 230 5.8E-36 T 09-03-2017 IPR011704 ATPase, dynein-related, AAA domain GO:0005524|GO:0016887 TK78_RS12545 ba312212f943ecbd99ba590686ae76b4 374 Gene3D G3DSA:3.40.50.300 74 241 7.7E-18 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS25900 ba7b497d29d00ed95085f59aa4c1e87b 357 Gene3D G3DSA:1.50.10.20 265 337 2.8E-16 T 09-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid TK78_RS25900 ba7b497d29d00ed95085f59aa4c1e87b 357 Gene3D G3DSA:1.50.10.20 23 225 2.8E-16 T 09-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid TK78_RS25900 ba7b497d29d00ed95085f59aa4c1e87b 357 SUPERFAMILY SSF48208 23 338 3.74E-39 T 09-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 TK78_RS15825 b58537ed2b495a2073d25a28914b16fd 153 SUPERFAMILY SSF103481 27 127 6.93E-17 T 09-03-2017 TK78_RS15825 b58537ed2b495a2073d25a28914b16fd 153 Pfam PF00893 Small Multidrug Resistance protein 24 115 7.5E-19 T 09-03-2017 IPR000390 Small multidrug resistance protein family GO:0016021 TK78_RS05280 1fb394b42eba6fd039655a3e6b5abb58 583 Pfam PF13556 PucR C-terminal helix-turn-helix domain 524 581 1.3E-22 T 09-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain TK78_RS05280 1fb394b42eba6fd039655a3e6b5abb58 583 Pfam PF07905 Purine catabolism regulatory protein-like family 6 120 1.2E-25 T 09-03-2017 IPR012914 Purine catabolism PurC-like domain TK78_RS09645 8db9228e5035d7f9f75c7e2944826848 399 SUPERFAMILY SSF55874 290 378 9.41E-9 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS09645 8db9228e5035d7f9f75c7e2944826848 399 Pfam PF07730 Histidine kinase 185 248 8.7E-15 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS04025 5636b9284939722046e6ac615f6fa180 101 SUPERFAMILY SSF55248 3 94 1.16E-22 T 09-03-2017 IPR001533 Transcriptional coactivator/pterin dehydratase GO:0006729|GO:0008124 MetaCyc: PWY-7158 TK78_RS04025 5636b9284939722046e6ac615f6fa180 101 Pfam PF01329 Pterin 4 alpha carbinolamine dehydratase 5 92 7.7E-22 T 09-03-2017 IPR001533 Transcriptional coactivator/pterin dehydratase GO:0006729|GO:0008124 MetaCyc: PWY-7158 TK78_RS04025 5636b9284939722046e6ac615f6fa180 101 Gene3D G3DSA:3.30.1360.20 2 94 5.3E-22 T 09-03-2017 IPR001533 Transcriptional coactivator/pterin dehydratase GO:0006729|GO:0008124 MetaCyc: PWY-7158 TK78_RS10630 7e5366fb755d0e248303b0e50d3fa5d8 528 SUPERFAMILY SSF53474 216 487 2.7E-20 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS10630 7e5366fb755d0e248303b0e50d3fa5d8 528 SUPERFAMILY SSF53474 108 172 2.7E-20 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS10630 7e5366fb755d0e248303b0e50d3fa5d8 528 Pfam PF08386 TAP-like protein 423 527 9.7E-32 T 09-03-2017 IPR013595 Peptidase S33 tripeptidyl aminopeptidase-like, C-terminal TK78_RS10630 7e5366fb755d0e248303b0e50d3fa5d8 528 Gene3D G3DSA:3.40.50.1820 394 515 4.3E-51 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS10630 7e5366fb755d0e248303b0e50d3fa5d8 528 Gene3D G3DSA:3.40.50.1820 219 334 4.3E-51 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS10630 7e5366fb755d0e248303b0e50d3fa5d8 528 Gene3D G3DSA:3.40.50.1820 90 174 4.3E-51 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS05810 0ed061828e6ce03d7e5175befb66cef0 213 Gene3D G3DSA:3.10.180.10 46 108 3.9E-13 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS05810 0ed061828e6ce03d7e5175befb66cef0 213 Gene3D G3DSA:3.10.180.10 125 189 2.7E-5 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS05810 0ed061828e6ce03d7e5175befb66cef0 213 SUPERFAMILY SSF54593 126 211 3.1E-6 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS05810 0ed061828e6ce03d7e5175befb66cef0 213 SUPERFAMILY SSF54593 10 110 2.34E-14 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS07960 aa34cfa2b390c5bdc2fc247507e55691 185 TIGRFAM TIGR02464 ribofla_fusion: conserved hypothetical protein 22 180 9.3E-47 T 09-03-2017 IPR012816 NADAR TK78_RS07960 aa34cfa2b390c5bdc2fc247507e55691 185 SUPERFAMILY SSF143990 15 181 5.1E-49 T 09-03-2017 TK78_RS07960 aa34cfa2b390c5bdc2fc247507e55691 185 Pfam PF08719 Domain of unknown function (DUF1768) 35 180 1.5E-49 T 09-03-2017 IPR012816 NADAR TK78_RS16645 953644735c20137d45e92e8fbc2087d4 397 SUPERFAMILY SSF56601 6 379 1.88E-74 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS16645 953644735c20137d45e92e8fbc2087d4 397 Gene3D G3DSA:3.40.710.10 6 390 6.0E-69 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS16645 953644735c20137d45e92e8fbc2087d4 397 Pfam PF00144 Beta-lactamase 11 376 9.2E-57 T 09-03-2017 IPR001466 Beta-lactamase-related TK78_RS12005 e56e41e540016dd5a6bd9a95531f190d 198 SUPERFAMILY SSF46689 16 96 1.52E-18 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS12005 e56e41e540016dd5a6bd9a95531f190d 198 Gene3D G3DSA:1.10.357.10 18 197 8.6E-42 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS12005 e56e41e540016dd5a6bd9a95531f190d 198 Pfam PF00440 Bacterial regulatory proteins, tetR family 31 75 5.9E-15 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS12005 e56e41e540016dd5a6bd9a95531f190d 198 SUPERFAMILY SSF48498 96 198 9.64E-13 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS12005 e56e41e540016dd5a6bd9a95531f190d 198 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 50 73 4.6E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS12005 e56e41e540016dd5a6bd9a95531f190d 198 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 30 43 4.6E-8 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS07310 f1ba3cee37036c9ecfbef9da02c50221 593 Pfam PF13777 Domain of unknown function (DUF4173) 329 520 3.0E-63 T 09-03-2017 IPR025231 Domain of unknown function DUF4173 TK78_RS10130 84567f14b94c6ae65a04954786d00efd 390 Pfam PF01757 Acyltransferase family 19 359 2.2E-21 T 09-03-2017 IPR002656 Acyltransferase 3 GO:0016747 TK78_RS22725 6193b617a5ed142f6a3edc0f4268382c 293 Pfam PF06182 ABC-2 family transporter protein 60 292 6.6E-61 T 09-03-2017 IPR010390 Protein of unknown function DUF990 TK78_RS32100 03a3a187066ab2b945f409b18ba7cb13 412 Pfam PF02653 Branched-chain amino acid transport system / permease component 66 400 2.2E-45 T 09-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 TK78_RS31635 6246ec0904bd6b88f32fba4ef9c9201b 261 Pfam PF01774 UreD urease accessory protein 48 240 3.7E-26 T 09-03-2017 IPR002669 Urease accessory protein UreD GO:0006807|GO:0016151 TK78_RS31635 6246ec0904bd6b88f32fba4ef9c9201b 261 Hamap MF_01384 Urease accessory protein UreD [ureD]. 3 252 19.535 T 09-03-2017 IPR002669 Urease accessory protein UreD GO:0006807|GO:0016151 TK78_RS22685 66178a882f7c9a5986e9b886960a60d7 219 Pfam PF01844 HNH endonuclease 157 200 1.4E-4 T 09-03-2017 IPR002711 HNH endonuclease GO:0003676|GO:0004519 TK78_RS04100 22d5b5d0ed2716f1b7fd740b3ffa0910 117 SUPERFAMILY SSF54593 8 109 4.81E-14 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS04100 22d5b5d0ed2716f1b7fd740b3ffa0910 117 Gene3D G3DSA:3.10.180.10 3 109 7.8E-17 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS10705 5d6e3de6574f91241eb7cde1c0015183 306 Gene3D G3DSA:3.40.50.1010 37 185 4.2E-16 T 09-03-2017 IPR029060 PIN domain-like TK78_RS10705 5d6e3de6574f91241eb7cde1c0015183 306 Pfam PF01936 NYN domain 43 187 2.1E-11 T 09-03-2017 IPR021139 NYN domain, limkain-b1-type TK78_RS20085 e4545f471c5f2875cc328a8ce148be73 178 SUPERFAMILY SSF54593 35 143 3.38E-10 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS20085 e4545f471c5f2875cc328a8ce148be73 178 Gene3D G3DSA:3.10.180.10 35 143 4.7E-9 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS28145 2b5820a9fb2148570d31987dc0db80af 127 SUPERFAMILY SSF54593 7 116 5.79E-13 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS28145 2b5820a9fb2148570d31987dc0db80af 127 Gene3D G3DSA:3.10.180.10 8 116 1.9E-11 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS12395 bbb46af5c17978f1b7bc12e479d034cb 468 Pfam PF00149 Calcineurin-like phosphoesterase 247 408 1.1E-11 T 09-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 TK78_RS12395 bbb46af5c17978f1b7bc12e479d034cb 468 Gene3D G3DSA:3.60.21.10 247 416 6.4E-22 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS12395 bbb46af5c17978f1b7bc12e479d034cb 468 SUPERFAMILY SSF56300 244 465 2.88E-37 T 09-03-2017 IPR029052 Metallo-dependent phosphatase-like TK78_RS22550 74de72254b6a68afe0769efd28d9e581 555 Pfam PF10708 Protein of unknown function (DUF2510) 16 46 7.3E-9 T 09-03-2017 IPR018929 Domain of unknown function DUF2510 TK78_RS22550 74de72254b6a68afe0769efd28d9e581 555 Pfam PF06271 RDD family 399 549 1.6E-23 T 09-03-2017 IPR010432 RDD TK78_RS10710 ccb344d0709740d1c27f1cf7e8eee637 201 Pfam PF01914 MarC family integral membrane protein 6 197 1.5E-46 T 09-03-2017 IPR002771 Multiple antibiotic resistance (MarC)-related GO:0016021 TK78_RS10710 ccb344d0709740d1c27f1cf7e8eee637 201 TIGRFAM TIGR00427 TIGR00427: membrane protein, MarC family 6 194 6.7E-44 T 09-03-2017 IPR002771 Multiple antibiotic resistance (MarC)-related GO:0016021 TK78_RS18015 48f40dee4f2563a52656960baeb0e02c 372 Pfam PF13228 Domain of unknown function (DUF4037) 155 253 1.1E-34 T 09-03-2017 IPR025117 Domain of unknown function DUF4037 TK78_RS20970 943e0546239d485e782172dbf1b36db4 367 Gene3D G3DSA:1.10.260.40 66 123 2.1E-6 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS15490 2f0780b3f13363a8b0cbf3d4ed04eb21 320 SUPERFAMILY SSF56349 3 295 6.77E-45 T 09-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 TK78_RS15490 2f0780b3f13363a8b0cbf3d4ed04eb21 320 Pfam PF00589 Phage integrase family 102 295 7.1E-17 T 09-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 TK78_RS15490 2f0780b3f13363a8b0cbf3d4ed04eb21 320 Gene3D G3DSA:1.10.443.10 102 295 3.9E-27 T 09-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 TK78_RS15490 2f0780b3f13363a8b0cbf3d4ed04eb21 320 Gene3D G3DSA:1.10.150.130 11 91 2.0E-9 T 09-03-2017 IPR023109 Integrase/recombinase, N-terminal TK78_RS28855 efee5c95b3f5d22491e114993f50aa74 308 Pfam PF14015 Protein of unknown function (DUF4231) 27 127 1.6E-17 T 09-03-2017 IPR025325 Protein of unknown function DUF4231 TK78_RS22175 c3746fec210fffc81ee8abcb3e0227af 1241 Pfam PF00535 Glycosyl transferase family 2 7 168 1.5E-32 T 09-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 TK78_RS22175 c3746fec210fffc81ee8abcb3e0227af 1241 Gene3D G3DSA:3.90.550.10 2 193 3.0E-51 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS22175 c3746fec210fffc81ee8abcb3e0227af 1241 SUPERFAMILY SSF53756 993 1237 4.08E-8 T 09-03-2017 TK78_RS22175 c3746fec210fffc81ee8abcb3e0227af 1241 SUPERFAMILY SSF53448 4 220 4.5E-52 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS22175 c3746fec210fffc81ee8abcb3e0227af 1241 Pfam PF04464 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase 882 1237 1.4E-76 T 09-03-2017 IPR007554 CDP-glycerol glycerophosphotransferase GO:0016020|GO:0047355 TK78_RS06150 31f398c4607c7c25f434f96ddce1dfce 154 Pfam PF07291 Methylamine utilisation protein MauE 3 133 6.7E-13 T 09-03-2017 IPR009908 Methylamine utilisation protein, MauE GO:0016021|GO:0030416 TK78_RS23150 a558e14e9942b9bce7a52c80d949bae8 341 Pfam PF14378 PAP2 superfamily 50 237 2.1E-60 T 09-03-2017 IPR026841 Inositolphosphotransferase Aur1/Ipt1 TK78_RS02545 e32efa2f35f7bd478f8e38ac66aae894 70 PRINTS PR01217 Proline rich extensin signature 17 38 2.3E-13 T 09-03-2017 TK78_RS02545 e32efa2f35f7bd478f8e38ac66aae894 70 PRINTS PR01217 Proline rich extensin signature 4 16 2.3E-13 T 09-03-2017 TK78_RS02545 e32efa2f35f7bd478f8e38ac66aae894 70 PRINTS PR01217 Proline rich extensin signature 44 60 2.3E-13 T 09-03-2017 TK78_RS29545 f644e62d1932a8121e36009e72370978 400 Gene3D G3DSA:3.20.20.10 114 275 1.2E-8 T 09-03-2017 IPR029066 PLP-binding barrel TK78_RS29545 f644e62d1932a8121e36009e72370978 400 SUPERFAMILY SSF51419 26 272 9.81E-21 T 09-03-2017 IPR029066 PLP-binding barrel TK78_RS29545 f644e62d1932a8121e36009e72370978 400 Pfam PF01168 Alanine racemase, N-terminal domain 25 273 1.3E-16 T 09-03-2017 IPR001608 Alanine racemase, N-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TK78_RS34450 01fdfb37b1e130cc314223dd076fc750 148 Pfam PF10604 Polyketide cyclase / dehydrase and lipid transport 4 146 6.6E-12 T 09-03-2017 IPR019587 Polyketide cyclase/dehydrase TK78_RS34450 01fdfb37b1e130cc314223dd076fc750 148 SUPERFAMILY SSF55961 4 147 3.8E-22 T 09-03-2017 TK78_RS34450 01fdfb37b1e130cc314223dd076fc750 148 Gene3D G3DSA:3.30.530.20 4 147 7.7E-14 T 09-03-2017 IPR023393 START-like domain TK78_RS03190 8ddaf61b698a218ff45f1638e6b1a11d 245 SUPERFAMILY SSF53448 1 237 2.07E-32 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS03190 8ddaf61b698a218ff45f1638e6b1a11d 245 Gene3D G3DSA:3.90.550.10 2 239 2.1E-34 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS03190 8ddaf61b698a218ff45f1638e6b1a11d 245 Pfam PF00483 Nucleotidyl transferase 3 161 3.9E-13 T 09-03-2017 IPR005835 Nucleotidyl transferase domain GO:0009058|GO:0016779 TK78_RS20825 a271110fd0707c1f2c2428d453b3c837 369 Gene3D G3DSA:1.20.950.20 126 257 9.3E-5 T 09-03-2017 TK78_RS20825 a271110fd0707c1f2c2428d453b3c837 369 Gene3D G3DSA:1.20.950.20 57 92 9.3E-5 T 09-03-2017 TK78_RS20825 a271110fd0707c1f2c2428d453b3c837 369 SUPERFAMILY SSF103501 57 91 3.92E-18 T 09-03-2017 IPR023234 NarG-like domain TK78_RS20825 a271110fd0707c1f2c2428d453b3c837 369 SUPERFAMILY SSF103501 126 296 3.92E-18 T 09-03-2017 IPR023234 NarG-like domain TK78_RS26350 25fe51d88f8ae2a704c4aa1837dcceb4 361 Pfam PF14378 PAP2 superfamily 93 273 2.4E-47 T 09-03-2017 IPR026841 Inositolphosphotransferase Aur1/Ipt1 TK78_RS21515 6c816dd08255b36cb234bcdf1192c584 248 Gene3D G3DSA:3.40.630.30 43 148 9.2E-8 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS21515 6c816dd08255b36cb234bcdf1192c584 248 SUPERFAMILY SSF55729 23 164 1.61E-8 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS25740 c4b4f7047cf08015e72ec304da6ed915 244 Pfam PF03649 Uncharacterised protein family (UPF0014) 12 238 1.1E-45 T 09-03-2017 IPR005226 UPF0014 family TK78_RS16455 4e658228c5e5538c924c9a4afc811554 252 SUPERFAMILY SSF53474 6 180 3.98E-22 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS16455 4e658228c5e5538c924c9a4afc811554 252 Gene3D G3DSA:3.40.50.1820 5 192 3.4E-22 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS16455 4e658228c5e5538c924c9a4afc811554 252 Pfam PF12697 Alpha/beta hydrolase family 10 150 4.0E-7 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS08320 f4c7b311d0937603d96dc0d92fdd22b0 77 Gene3D G3DSA:3.30.70.920 4 75 4.0E-17 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS08320 f4c7b311d0937603d96dc0d92fdd22b0 77 Pfam PF01037 Lrp/AsnC ligand binding domain 6 74 1.4E-12 T 09-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TK78_RS08320 f4c7b311d0937603d96dc0d92fdd22b0 77 SUPERFAMILY SSF54909 2 75 1.88E-14 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS04495 e5978556708a73af7a46cc7d01f94c14 373 Gene3D G3DSA:2.140.10.10 35 329 4.0E-6 T 09-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain TK78_RS04495 e5978556708a73af7a46cc7d01f94c14 373 Pfam PF14269 Arylsulfotransferase (ASST) 112 332 9.7E-18 T 09-03-2017 TK78_RS04495 e5978556708a73af7a46cc7d01f94c14 373 SUPERFAMILY SSF50998 16 134 1.49E-11 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS04495 e5978556708a73af7a46cc7d01f94c14 373 SUPERFAMILY SSF50998 164 332 1.49E-11 T 09-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily TK78_RS22325 54a970d121f38100957cd10ccd1402c1 187 Gene3D G3DSA:3.40.630.30 8 179 1.5E-44 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS22325 54a970d121f38100957cd10ccd1402c1 187 SUPERFAMILY SSF55729 7 179 9.37E-42 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS22325 54a970d121f38100957cd10ccd1402c1 187 Pfam PF13302 Acetyltransferase (GNAT) domain 13 155 8.4E-23 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS33925 aff1a5233b8da9730d486166a63e853f 134 Pfam PF09350 Domain of unknown function (DUF1992) 14 79 6.2E-19 T 09-03-2017 IPR018961 DnaJ homologue, subfamily C, member 28, conserved domain TK78_RS29265 9219e9a39a11b501fc640676999bed3a 352 Gene3D G3DSA:3.20.20.30 1 345 4.7E-88 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS29265 9219e9a39a11b501fc640676999bed3a 352 SUPERFAMILY SSF51679 1 345 1.57E-77 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS29265 9219e9a39a11b501fc640676999bed3a 352 Pfam PF00296 Luciferase-like monooxygenase 1 306 2.5E-68 T 09-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 TK78_RS01000 bc379e6805405570b279e497868bd239 301 Pfam PF09995 Uncharacterized protein conserved in bacteria (DUF2236) 43 248 4.2E-19 T 09-03-2017 IPR018713 Domain of unknown function DUF2236 TK78_RS00880 23faaa3796a9c69d97e2cf779593c77f 344 Pfam PF05231 MASE1 23 294 3.2E-48 T 09-03-2017 IPR007895 MASE1 TK78_RS31010 d53f5e2881408c76909967dd30d99eaf 362 Gene3D G3DSA:3.30.360.10 138 350 2.1E-34 T 09-03-2017 TK78_RS31010 d53f5e2881408c76909967dd30d99eaf 362 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 138 190 1.4E-5 T 09-03-2017 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 TK78_RS31010 d53f5e2881408c76909967dd30d99eaf 362 SUPERFAMILY SSF51735 3 169 2.35E-35 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31010 d53f5e2881408c76909967dd30d99eaf 362 Gene3D G3DSA:3.40.50.720 3 137 1.4E-32 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS31010 d53f5e2881408c76909967dd30d99eaf 362 SUPERFAMILY SSF55347 129 317 2.22E-26 T 09-03-2017 TK78_RS31010 d53f5e2881408c76909967dd30d99eaf 362 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 3 119 1.2E-22 T 09-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 TK78_RS14975 f4ba3cbe3d205cba91f93925c5f30ff6 83 Pfam PF05402 Coenzyme PQQ synthesis protein D (PqqD) 17 81 2.2E-12 T 09-03-2017 IPR008792 Coenzyme PQQ synthesis D TK78_RS19425 dd37a163b89ed769911155bf0436fd2a 191 Pfam PF02342 TerD domain 1 187 1.5E-83 T 09-03-2017 IPR003325 TerD domain GO:0006950 TK78_RS19425 dd37a163b89ed769911155bf0436fd2a 191 Gene3D G3DSA:2.60.60.30 18 185 8.1E-73 T 09-03-2017 TK78_RS21620 ea133affbf8ef6bdb6dc8d960986f17d 293 Pfam PF12811 Bax inhibitor 1 like 24 290 4.1E-81 T 09-03-2017 IPR010539 Protein of unknown function UCP009160 TK78_RS21620 ea133affbf8ef6bdb6dc8d960986f17d 293 PIRSF PIRSF009160 1 293 3.4E-101 T 09-03-2017 IPR010539 Protein of unknown function UCP009160 TK78_RS07005 05088704edfcaea6c771bc28a7c18115 410 Pfam PF13489 Methyltransferase domain 98 241 1.2E-14 T 09-03-2017 TK78_RS07005 05088704edfcaea6c771bc28a7c18115 410 SUPERFAMILY SSF53335 90 252 5.17E-17 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS07005 05088704edfcaea6c771bc28a7c18115 410 Gene3D G3DSA:3.40.50.150 96 251 1.2E-14 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS07005 05088704edfcaea6c771bc28a7c18115 410 Pfam PF08484 C-methyltransferase C-terminal domain 247 405 6.9E-47 T 09-03-2017 IPR013691 C-methyltransferase TK78_RS07005 05088704edfcaea6c771bc28a7c18115 410 Pfam PF08421 Putative zinc binding domain 6 67 1.1E-13 T 09-03-2017 IPR013630 Methyltransferase putative zinc binding domain TK78_RS16185 43760f5f86740eb11b3377136403c491 372 Pfam PF00487 Fatty acid desaturase 67 334 1.3E-25 T 09-03-2017 IPR005804 Fatty acid desaturase domain GO:0006629 TK78_RS05880 c542dff49ad2976fa97c6656f8e6e299 344 TIGRFAM TIGR04222 near_uncomplex: TIGR04222 domain 7 237 4.6E-53 T 09-03-2017 IPR026467 Ser/Gly rich, Cys interspersed, C-terminal domain TK78_RS31180 067b310f263269cc5290dee6ec5c53b6 414 Pfam PF13535 ATP-grasp domain 147 290 2.6E-15 T 09-03-2017 TK78_RS31180 067b310f263269cc5290dee6ec5c53b6 414 SUPERFAMILY SSF56059 113 316 2.19E-29 T 09-03-2017 TK78_RS31180 067b310f263269cc5290dee6ec5c53b6 414 Gene3D G3DSA:3.30.470.20 110 319 4.6E-22 T 09-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 TK78_RS11045 1006c4910522e730fcbf4f8ab9ed5270 486 Pfam PF10091 Putative glucoamylase 278 467 7.2E-12 T 09-03-2017 IPR019282 Domain of unknown function DUF2329 TK78_RS10780 841e2a8a8d5b802218964bd9d6670d66 356 Pfam PF13490 Putative zinc-finger 18 46 1.8E-6 T 09-03-2017 IPR027383 Putative zinc-finger TK78_RS28100 85fad19b9b338cd58985dcf6cb82f0f5 308 SUPERFAMILY SSF53474 21 304 8.84E-32 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS28100 85fad19b9b338cd58985dcf6cb82f0f5 308 Gene3D G3DSA:3.40.50.1820 24 304 2.3E-30 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS28100 85fad19b9b338cd58985dcf6cb82f0f5 308 Pfam PF00561 alpha/beta hydrolase fold 49 156 3.8E-14 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS24320 d6a93497aead5c804461c289574bfa2c 228 SUPERFAMILY SSF47240 7 162 8.55E-41 T 09-03-2017 IPR009078 Ferritin-like superfamily TK78_RS24320 d6a93497aead5c804461c289574bfa2c 228 ProSitePatterns PS00818 Dps protein family signature 1. 44 60 - T 09-03-2017 IPR023188 DNA-binding protein Dps, conserved site GO:0016722|GO:0055114 TK78_RS24320 d6a93497aead5c804461c289574bfa2c 228 PRINTS PR01346 Helicobacter neutrophil-activating protein A family signature 44 60 1.8E-11 T 09-03-2017 IPR002177 DNA-binding protein Dps GO:0006950|GO:0055114 TK78_RS24320 d6a93497aead5c804461c289574bfa2c 228 PRINTS PR01346 Helicobacter neutrophil-activating protein A family signature 139 157 1.8E-11 T 09-03-2017 IPR002177 DNA-binding protein Dps GO:0006950|GO:0055114 TK78_RS24320 d6a93497aead5c804461c289574bfa2c 228 PRINTS PR01346 Helicobacter neutrophil-activating protein A family signature 68 84 1.8E-11 T 09-03-2017 IPR002177 DNA-binding protein Dps GO:0006950|GO:0055114 TK78_RS24320 d6a93497aead5c804461c289574bfa2c 228 Gene3D G3DSA:1.20.1260.10 9 163 1.2E-43 T 09-03-2017 IPR012347 Ferritin-related TK78_RS24320 d6a93497aead5c804461c289574bfa2c 228 Pfam PF00210 Ferritin-like domain 24 162 4.5E-23 T 09-03-2017 IPR008331 Ferritin/DPS protein domain GO:0006879|GO:0008199 TK78_RS23485 6d6ad8b220ff5f7fc32c8a521b9c6f34 407 Pfam PF04235 Protein of unknown function (DUF418) 250 396 1.5E-33 T 09-03-2017 IPR007349 Domain of unknown function DUF418 TK78_RS20405 c75692ac51d145b7f8842beac5836457 374 Pfam PF04616 Glycosyl hydrolases family 43 56 307 2.7E-29 T 09-03-2017 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 TK78_RS20405 c75692ac51d145b7f8842beac5836457 374 SUPERFAMILY SSF75005 55 310 8.99E-40 T 09-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain TK78_RS20405 c75692ac51d145b7f8842beac5836457 374 Gene3D G3DSA:2.115.10.20 58 351 2.4E-53 T 09-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain TK78_RS08890 f98f7fd5836fcf0875300cdde283264f 267 SUPERFAMILY SSF53474 5 257 2.87E-25 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS08890 f98f7fd5836fcf0875300cdde283264f 267 Gene3D G3DSA:3.40.50.1820 2 257 9.4E-27 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS08890 f98f7fd5836fcf0875300cdde283264f 267 Pfam PF12697 Alpha/beta hydrolase family 23 228 1.1E-11 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS32525 b259d197eb6887d83aa0edac96e631d7 311 Pfam PF01435 Peptidase family M48 123 181 5.1E-9 T 09-03-2017 IPR001915 Peptidase M48 GO:0004222|GO:0006508 TK78_RS32525 b259d197eb6887d83aa0edac96e631d7 311 Gene3D G3DSA:3.30.2010.10 125 182 1.8E-13 T 09-03-2017 TK78_RS24240 eee62d1ff7c2c0db84d744f27e8b8ae7 216 SUPERFAMILY SSF52833 13 176 4.48E-22 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS24240 eee62d1ff7c2c0db84d744f27e8b8ae7 216 Gene3D G3DSA:3.40.30.10 10 174 5.8E-13 T 09-03-2017 IPR012336 Thioredoxin-like fold TK78_RS24240 eee62d1ff7c2c0db84d744f27e8b8ae7 216 Pfam PF01323 DSBA-like thioredoxin domain 13 174 3.2E-10 T 09-03-2017 IPR001853 DSBA-like thioredoxin domain GO:0015035 Reactome: R-HSA-156590 TK78_RS01730 fca03f94f5321333f426792b2a1fe6f3 425 Gene3D G3DSA:2.130.10.10 356 401 6.2E-9 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS01730 fca03f94f5321333f426792b2a1fe6f3 425 Gene3D G3DSA:2.130.10.10 15 140 6.2E-9 T 09-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 TK78_RS01730 fca03f94f5321333f426792b2a1fe6f3 425 SUPERFAMILY SSF51004 274 401 1.96E-12 T 09-03-2017 IPR011048 Cytochrome cd1-nitrite reductase-like, haem d1 domain TK78_RS01730 fca03f94f5321333f426792b2a1fe6f3 425 SUPERFAMILY SSF51004 8 170 1.96E-12 T 09-03-2017 IPR011048 Cytochrome cd1-nitrite reductase-like, haem d1 domain TK78_RS12220 5f825d7ad18ab5b3153d59ed0901fc21 327 Pfam PF00535 Glycosyl transferase family 2 5 131 1.4E-32 T 09-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 TK78_RS12220 5f825d7ad18ab5b3153d59ed0901fc21 327 Gene3D G3DSA:3.90.550.10 3 201 2.9E-44 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS12220 5f825d7ad18ab5b3153d59ed0901fc21 327 SUPERFAMILY SSF53448 3 226 2.31E-45 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS32800 8595381f433cba6df68839612485edbe 250 Pfam PF07398 MDMPI C-terminal domain 145 239 2.9E-12 T 09-03-2017 IPR010872 MDMPI C-terminal TK78_RS32800 8595381f433cba6df68839612485edbe 250 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 15 129 5.9E-21 T 09-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 TK78_RS32800 8595381f433cba6df68839612485edbe 250 TIGRFAM TIGR03083 TIGR03083: uncharacterized Actinobacterial protein TIGR03083 10 224 4.5E-28 T 09-03-2017 IPR017517 Conserved hypothetical protein CHP03083, actinobacterial-type TK78_RS32800 8595381f433cba6df68839612485edbe 250 SUPERFAMILY SSF109854 5 134 2.2E-11 T 09-03-2017 TK78_RS27335 b0b50705e3eafd28bcee50edd4f84738 247 Pfam PF10825 Protein of unknown function (DUF2752) 153 201 4.2E-14 T 09-03-2017 IPR021215 Protein of unknown function DUF2752 TK78_RS30490 6048ad5b335ede041bb6cff53922bbf9 156 Pfam PF10756 Bacterial PH domain 69 139 6.2E-19 T 09-03-2017 IPR019692 Protein of unknown function DUF2581 TK78_RS05005 4efc93f18f0a2dc3398da1ca73481a18 83 Gene3D G3DSA:3.30.70.930 5 77 6.3E-6 T 09-03-2017 IPR029756 MTH1187/YkoF-like TK78_RS05005 4efc93f18f0a2dc3398da1ca73481a18 83 SUPERFAMILY SSF89957 3 77 1.51E-7 T 09-03-2017 IPR029756 MTH1187/YkoF-like TK78_RS30200 d4d07185d60238a47b276d78838496b5 212 Pfam PF07884 Vitamin K epoxide reductase family 32 163 2.4E-28 T 09-03-2017 IPR012932 Vitamin K epoxide reductase Reactome: R-HSA-6806664 TK78_RS30200 d4d07185d60238a47b276d78838496b5 212 SMART SM00756 26 167 6.9E-48 T 09-03-2017 IPR012932 Vitamin K epoxide reductase Reactome: R-HSA-6806664 TK78_RS26770 b7c24555762ca55a12650a39c3ca2eb5 417 Pfam PF03734 L,D-transpeptidase catalytic domain 245 366 2.0E-16 T 09-03-2017 IPR005490 L,D-transpeptidase catalytic domain GO:0016740 TK78_RS26770 b7c24555762ca55a12650a39c3ca2eb5 417 SUPERFAMILY SSF141523 241 366 7.06E-29 T 09-03-2017 TK78_RS26770 b7c24555762ca55a12650a39c3ca2eb5 417 Gene3D G3DSA:2.40.440.10 244 367 1.2E-19 T 09-03-2017 TK78_RS01940 fbea837fcb6fda4c7f0c7bb7f38ee2bc 196 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 22 184 2.3E-24 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS01940 fbea837fcb6fda4c7f0c7bb7f38ee2bc 196 SMART SM00855 4 150 1.2E-5 T 09-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 TK78_RS01940 fbea837fcb6fda4c7f0c7bb7f38ee2bc 196 SUPERFAMILY SSF53254 15 184 1.31E-28 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS01940 fbea837fcb6fda4c7f0c7bb7f38ee2bc 196 Gene3D G3DSA:3.40.50.1240 17 184 2.5E-24 T 09-03-2017 IPR029033 Histidine phosphatase superfamily TK78_RS22840 9fe07f7a36ece9c7b36695bbb5c7b6f9 206 Pfam PF13581 Histidine kinase-like ATPase domain 17 129 1.6E-8 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS26695 7a9beaa0d7d23a45dc5d1a769cd0ff72 261 Pfam PF04012 PspA/IM30 family 2 227 1.9E-29 T 09-03-2017 IPR007157 PspA/IM30 TK78_RS00055 8bd73dd9449c956341289fec9cfea5c8 188 Pfam PF13643 Domain of unknown function (DUF4145) 72 155 4.3E-13 T 09-03-2017 IPR025285 Domain of unknown function DUF4145 TK78_RS22640 bec6e6c2f78003d13484ace30de94f6e 168 Pfam PF13508 Acetyltransferase (GNAT) domain 66 140 6.2E-8 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS22640 bec6e6c2f78003d13484ace30de94f6e 168 Gene3D G3DSA:3.40.630.30 1 143 4.6E-16 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS22640 bec6e6c2f78003d13484ace30de94f6e 168 SUPERFAMILY SSF55729 1 152 1.37E-15 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS16320 07b1bba28ef7521fb6408c1b1b735405 445 PRINTS PR00359 B-class P450 signature 280 307 5.4E-16 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS16320 07b1bba28ef7521fb6408c1b1b735405 445 PRINTS PR00359 B-class P450 signature 87 98 5.4E-16 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS16320 07b1bba28ef7521fb6408c1b1b735405 445 PRINTS PR00359 B-class P450 signature 183 205 5.4E-16 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS16320 07b1bba28ef7521fb6408c1b1b735405 445 PRINTS PR00359 B-class P450 signature 133 149 5.4E-16 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS16320 07b1bba28ef7521fb6408c1b1b735405 445 SUPERFAMILY SSF48264 2 387 6.94E-57 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS16320 07b1bba28ef7521fb6408c1b1b735405 445 Gene3D G3DSA:1.10.630.10 1 388 2.4E-76 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS10770 6e348da64460ffd629d81dd50c4dc43e 166 Hamap MF_00237 Sec-independent protein translocase protein TatB [tatB]. 2 141 13.939 T 09-03-2017 IPR018448 Twin-arginine translocation protein TatB GO:0016020|GO:0043953 TK78_RS10770 6e348da64460ffd629d81dd50c4dc43e 166 Pfam PF02416 mttA/Hcf106 family 5 43 6.1E-6 T 09-03-2017 IPR003369 Sec-independent protein translocase protein TatA/B/E GO:0008565|GO:0015031 TK78_RS10770 6e348da64460ffd629d81dd50c4dc43e 166 PRINTS PR01506 Bacterial sec-independent translocation TatB protein signature 41 59 2.1E-9 T 09-03-2017 IPR003998 Twin-arginine translocation protein TatB-like GO:0009306|GO:0016020 TK78_RS10770 6e348da64460ffd629d81dd50c4dc43e 166 PRINTS PR01506 Bacterial sec-independent translocation TatB protein signature 22 41 2.1E-9 T 09-03-2017 IPR003998 Twin-arginine translocation protein TatB-like GO:0009306|GO:0016020 TK78_RS10770 6e348da64460ffd629d81dd50c4dc43e 166 PRINTS PR01506 Bacterial sec-independent translocation TatB protein signature 2 22 2.1E-9 T 09-03-2017 IPR003998 Twin-arginine translocation protein TatB-like GO:0009306|GO:0016020 TK78_RS04235 2b8d1a62655995b81a06a84e68176006 167 Gene3D G3DSA:3.10.129.10 2 149 2.3E-41 T 09-03-2017 IPR029069 HotDog domain TK78_RS04235 2b8d1a62655995b81a06a84e68176006 167 SUPERFAMILY SSF54637 2 148 6.44E-43 T 09-03-2017 IPR029069 HotDog domain TK78_RS04235 2b8d1a62655995b81a06a84e68176006 167 Pfam PF01575 MaoC like domain 12 123 2.2E-15 T 09-03-2017 IPR002539 MaoC-like domain TK78_RS18775 80843f3fdde4f5e2d8bde144cb6aac15 151 Gene3D G3DSA:2.60.120.10 65 144 2.6E-11 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS18775 80843f3fdde4f5e2d8bde144cb6aac15 151 Pfam PF12973 ChrR Cupin-like domain 66 143 1.2E-9 T 09-03-2017 IPR025979 ChrR-like cupin domain TK78_RS18775 80843f3fdde4f5e2d8bde144cb6aac15 151 SUPERFAMILY SSF51182 53 143 1.04E-15 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS18765 53d8a9348aa432c0395a413643b7c653 443 TIGRFAM TIGR01167 LPXTG_anchor: LPXTG cell wall anchor domain 403 438 3.8E-5 T 09-03-2017 IPR019931 LPXTG cell wall anchor domain TK78_RS13685 bab24669870200ade835da372251e4d2 204 Pfam PF07336 Putative stress-induced transcription regulator 4 148 3.7E-16 T 09-03-2017 IPR010852 Putative stress-induced transcription regulator TK78_RS13685 bab24669870200ade835da372251e4d2 204 Gene3D G3DSA:1.10.3300.10 2 194 1.2E-37 T 09-03-2017 IPR023286 ABATE domain TK78_RS13685 bab24669870200ade835da372251e4d2 204 Pfam PF11706 CGNR zinc finger 153 191 3.4E-11 T 09-03-2017 IPR021005 Zinc finger, CGNR TK78_RS13685 bab24669870200ade835da372251e4d2 204 SUPERFAMILY SSF160904 2 191 6.28E-37 T 09-03-2017 TK78_RS32700 9f42e20f39067e5456e2f9969c35aaba 240 SUPERFAMILY SSF69593 20 205 7.06E-37 T 09-03-2017 TK78_RS32700 9f42e20f39067e5456e2f9969c35aaba 240 Pfam PF01553 Acyltransferase 24 149 4.2E-28 T 09-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 TK78_RS32700 9f42e20f39067e5456e2f9969c35aaba 240 SMART SM00563 38 152 3.7E-36 T 09-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 TK78_RS32700 9f42e20f39067e5456e2f9969c35aaba 240 Gene3D G3DSA:3.40.1130.10 27 205 1.9E-23 T 09-03-2017 TK78_RS15655 410295072a6876cade3c7aa0515dfc37 603 SUPERFAMILY SSF82171 30 323 2.2E-21 T 09-03-2017 TK78_RS15655 410295072a6876cade3c7aa0515dfc37 603 SUPERFAMILY SSF53474 348 596 1.18E-52 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS15655 410295072a6876cade3c7aa0515dfc37 603 Gene3D G3DSA:2.120.10.30 28 309 2.6E-24 T 09-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like TK78_RS15655 410295072a6876cade3c7aa0515dfc37 603 Pfam PF00326 Prolyl oligopeptidase family 394 596 4.8E-40 T 09-03-2017 IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain GO:0006508|GO:0008236 TK78_RS15655 410295072a6876cade3c7aa0515dfc37 603 Gene3D G3DSA:3.40.50.1820 351 596 2.1E-53 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS31555 d2a7a0830c8eefd97e5926bf0bb84edc 84 Pfam PF04149 Domain of unknown function (DUF397) 22 73 1.1E-19 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS17345 113871c182d985181f2d7f91745a130e 421 Pfam PF02096 60Kd inner membrane protein 38 255 2.0E-58 T 09-03-2017 IPR001708 Membrane insertase OXA1/ALB3/YidC GO:0016021|GO:0051205 TK78_RS17345 113871c182d985181f2d7f91745a130e 421 TIGRFAM TIGR03592 yidC_oxa1_cterm: membrane protein insertase, YidC/Oxa1 family 38 255 2.8E-63 T 09-03-2017 IPR028055 Membrane insertase YidC/Oxa1, C-terminal TK78_RS33005 22c82426530cb854b2be867d620d4571 489 SUPERFAMILY SSF52091 416 483 2.16E-5 T 09-03-2017 IPR002645 STAS domain TK78_RS33005 22c82426530cb854b2be867d620d4571 489 Pfam PF00916 Sulfate permease family 14 380 1.4E-57 T 09-03-2017 IPR011547 SLC26A/SulP transporter domain GO:0008272|GO:0015116|GO:0016021 TK78_RS30765 5bc296952b603c8329bd65db9e88705d 110 Pfam PF06947 Protein of unknown function (DUF1290) 21 108 2.4E-33 T 09-03-2017 IPR009709 Protein of unknown function DUF1290 TK78_RS30765 5bc296952b603c8329bd65db9e88705d 110 PIRSF PIRSF018579 1 110 5.8E-46 T 09-03-2017 IPR009709 Protein of unknown function DUF1290 TK78_RS13735 f36b883a18d6065fe3ad540e66383ab2 349 Pfam PF11350 Protein of unknown function (DUF3152) 162 325 9.6E-32 T 09-03-2017 IPR022603 Domain of unknown function DUF3152 TK78_RS13735 f36b883a18d6065fe3ad540e66383ab2 349 Gene3D G3DSA:3.40.390.10 217 311 4.5E-4 T 09-03-2017 IPR024079 Metallopeptidase, catalytic domain GO:0008237 TK78_RS13735 f36b883a18d6065fe3ad540e66383ab2 349 SUPERFAMILY SSF55486 204 326 4.05E-14 T 09-03-2017 TK78_RS29120 ef2a3e5d812a77f0ed0f18801936e589 131 Pfam PF02656 Domain of unknown function (DUF202) 27 92 9.9E-15 T 09-03-2017 IPR003807 Domain of unknown function DUF202 TK78_RS09965 e595e9d4cc5d353c569be78e3308a182 264 Pfam PF13672 Protein phosphatase 2C 16 207 1.5E-6 T 09-03-2017 TK78_RS01930 94ec34b608924f36ed91ca29c00e42cb 251 Pfam PF09490 Probable cobalt transporter subunit (CbtA) 7 231 4.1E-70 T 09-03-2017 IPR012666 Cobalt transporter subunit CbtA, putative TK78_RS05390 d828e68ec6c7d7fe20d0fdc5bc2aa4e8 230 Pfam PF03777 Small secreted domain (DUF320) 24 79 8.3E-29 T 09-03-2017 IPR005528 Domain of unknown function DUF320, Streptomyces species TK78_RS24335 cd251e07578f5fdef491a47f754a4b67 490 ProSitePatterns PS00218 Amino acid permeases signature. 57 87 - T 09-03-2017 IPR004840 Amino acid permease, conserved site GO:0006865|GO:0016021|GO:0055085 TK78_RS24335 cd251e07578f5fdef491a47f754a4b67 490 Pfam PF00324 Amino acid permease 32 469 6.0E-103 T 09-03-2017 IPR004841 Amino acid permease/ SLC12A domain GO:0006810|GO:0016020|GO:0055085 TK78_RS24335 cd251e07578f5fdef491a47f754a4b67 490 PIRSF PIRSF006060 11 489 1.7E-71 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS24250 0d43db90d9f33a2e76602ab00f73b3ee 115 Gene3D G3DSA:3.10.180.10 5 110 4.2E-15 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS24250 0d43db90d9f33a2e76602ab00f73b3ee 115 SUPERFAMILY SSF54593 7 110 4.26E-18 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS18525 512fd613180274ddb13abe61d0da46d7 264 Pfam PF12730 ABC-2 family transporter protein 19 141 6.2E-8 T 09-03-2017 IPR032688 ABC-2 family transporter protein GO:0006810 TK78_RS03180 1a3e2cc132230d4099b3be892731db83 259 Pfam PF01066 CDP-alcohol phosphatidyltransferase 49 115 4.6E-9 T 09-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 TK78_RS17200 f0582bf4454a696e5fe2c1fe82ef27c7 197 SUPERFAMILY SSF48498 78 182 1.11E-17 T 09-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal TK78_RS17200 f0582bf4454a696e5fe2c1fe82ef27c7 197 SUPERFAMILY SSF46689 6 64 5.08E-9 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS17200 f0582bf4454a696e5fe2c1fe82ef27c7 197 Gene3D G3DSA:1.10.10.60 3 49 8.5E-15 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS17200 f0582bf4454a696e5fe2c1fe82ef27c7 197 Pfam PF00440 Bacterial regulatory proteins, tetR family 14 53 8.3E-7 T 09-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TK78_RS17200 f0582bf4454a696e5fe2c1fe82ef27c7 197 Gene3D G3DSA:1.10.357.10 50 186 1.1E-37 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS06585 8c967b3b70297cb8a7f6cab2a7f22cd1 581 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 104 482 1.9E-66 T 09-03-2017 IPR000914 Solute-binding protein family 5 domain TK78_RS06585 8c967b3b70297cb8a7f6cab2a7f22cd1 581 PIRSF PIRSF002741 1 568 3.5E-64 T 09-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 TK78_RS06585 8c967b3b70297cb8a7f6cab2a7f22cd1 581 Gene3D G3DSA:3.90.76.10 66 232 1.7E-29 T 09-03-2017 TK78_RS06585 8c967b3b70297cb8a7f6cab2a7f22cd1 581 Gene3D G3DSA:3.10.105.10 341 542 4.2E-41 T 09-03-2017 TK78_RS06585 8c967b3b70297cb8a7f6cab2a7f22cd1 581 SUPERFAMILY SSF53850 51 570 6.15E-91 T 09-03-2017 TK78_RS06585 8c967b3b70297cb8a7f6cab2a7f22cd1 581 Gene3D G3DSA:3.40.190.10 233 340 7.3E-15 T 09-03-2017 TK78_RS23860 311f2df556215e0cf54fd31cef8bfac9 360 SUPERFAMILY SSF55874 248 351 1.83E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS23860 311f2df556215e0cf54fd31cef8bfac9 360 Pfam PF07730 Histidine kinase 149 213 1.6E-9 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS24975 5156a18ac7a3a09da1bcb1ed97a2cf27 69 Pfam PF04149 Domain of unknown function (DUF397) 7 61 6.3E-21 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS09195 89bc7c24763668c6186896f71c34c522 191 Pfam PF09684 Phage tail protein (Tail_P2_I) 36 129 6.4E-17 T 09-03-2017 IPR006521 Tail protein I TK78_RS09195 89bc7c24763668c6186896f71c34c522 191 TIGRFAM TIGR02242 tail_TIGR02242: phage tail protein domain 18 117 3.0E-33 T 09-03-2017 IPR011748 Uncharacterised protein family, phage tail-like TK78_RS05765 e11230b6f7ff0b5d77fea5fd2b943a8c 122 SUPERFAMILY SSF54593 1 119 5.1E-20 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS05765 e11230b6f7ff0b5d77fea5fd2b943a8c 122 Gene3D G3DSA:3.10.180.10 8 119 2.3E-17 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS05765 e11230b6f7ff0b5d77fea5fd2b943a8c 122 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 8 116 1.2E-5 T 09-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain TK78_RS29190 350fe5bcc1c04be53170bd08d28dc630 77 Pfam PF03777 Small secreted domain (DUF320) 21 76 1.5E-30 T 09-03-2017 IPR005528 Domain of unknown function DUF320, Streptomyces species TK78_RS15695 63c7db27527329c64b11a0acbf5cafd9 281 Gene3D G3DSA:3.40.50.720 1 213 3.3E-41 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS15695 63c7db27527329c64b11a0acbf5cafd9 281 SUPERFAMILY SSF51735 4 272 5.18E-47 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS15695 63c7db27527329c64b11a0acbf5cafd9 281 Pfam PF13460 NAD(P)H-binding 7 179 9.2E-22 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS03305 b3f9e33f8326609c8f03b1a3fbe8c068 158 SMART SM00506 3 141 2.5E-19 T 09-03-2017 IPR002589 Macro domain TK78_RS03305 b3f9e33f8326609c8f03b1a3fbe8c068 158 SUPERFAMILY SSF52949 4 156 1.79E-42 T 09-03-2017 TK78_RS24935 75783067f47b783f73335cddd39a9398 254 SUPERFAMILY SSF53474 22 89 4.68E-12 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS24935 75783067f47b783f73335cddd39a9398 254 SUPERFAMILY SSF53474 127 251 4.68E-12 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS24935 75783067f47b783f73335cddd39a9398 254 Gene3D G3DSA:3.40.50.1820 21 249 2.8E-12 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS10430 6aedebf3500505e92fbd935f125c95e0 216 Pfam PF13529 Peptidase_C39 like family 13 179 6.5E-6 T 09-03-2017 TK78_RS04500 48fe054eb6125de52d79da6296b98f48 466 ProSitePatterns PS01116 Xanthine/uracil permeases family signature. 338 358 - T 09-03-2017 IPR006042 Xanthine/uracil permease GO:0005215|GO:0016020|GO:0055085 Reactome: R-HSA-196836 TK78_RS04500 48fe054eb6125de52d79da6296b98f48 466 Pfam PF00860 Permease family 17 389 3.8E-52 T 09-03-2017 IPR006043 Xanthine/uracil/vitamin C permease GO:0005215|GO:0006810|GO:0016020|GO:0055085 TK78_RS23490 6e4f6166b1332b32d4f54f081da9ffd1 731 Pfam PF01757 Acyltransferase family 39 374 2.1E-27 T 09-03-2017 IPR002656 Acyltransferase 3 GO:0016747 TK78_RS26540 3c137a815fc79c30e27fab866a5eb37f 129 SUPERFAMILY SSF51182 36 120 2.1E-7 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS26540 3c137a815fc79c30e27fab866a5eb37f 129 Gene3D G3DSA:2.60.120.10 49 110 2.7E-7 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS34050 9addcecedf4e2a3c98db83c2f18f47ff 331 SUPERFAMILY SSF55469 211 329 6.67E-9 T 09-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TK78_RS34050 9addcecedf4e2a3c98db83c2f18f47ff 331 SUPERFAMILY SSF55469 117 183 6.67E-9 T 09-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TK78_RS34050 9addcecedf4e2a3c98db83c2f18f47ff 331 Gene3D G3DSA:3.40.109.10 236 329 6.6E-16 T 09-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TK78_RS34050 9addcecedf4e2a3c98db83c2f18f47ff 331 Gene3D G3DSA:3.40.109.10 117 186 6.6E-16 T 09-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TK78_RS34050 9addcecedf4e2a3c98db83c2f18f47ff 331 Gene3D G3DSA:3.40.109.30 12 93 1.9E-11 T 09-03-2017 TK78_RS34050 9addcecedf4e2a3c98db83c2f18f47ff 331 SUPERFAMILY SSF55469 13 86 3.66E-8 T 09-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TK78_RS27405 826f8e8f100d3b763b40f985cf5a95df 243 Pfam PF01988 VIT family 28 235 1.4E-62 T 09-03-2017 IPR008217 Ccc1 family TK78_RS01960 24330070cc3d761f4f32ccac7d20a12b 295 Gene3D G3DSA:3.90.550.10 7 221 2.3E-9 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS01960 24330070cc3d761f4f32ccac7d20a12b 295 SUPERFAMILY SSF53448 6 222 4.28E-13 T 09-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases TK78_RS18040 bcd96fee48ce6d7aaa736a982be541e8 79 Pfam PF01361 Tautomerase enzyme 2 57 2.3E-14 T 09-03-2017 IPR004370 4-oxalocrotonate tautomerase GO:0006725|GO:0016853 TK78_RS18040 bcd96fee48ce6d7aaa736a982be541e8 79 SUPERFAMILY SSF55331 2 60 1.31E-15 T 09-03-2017 IPR014347 Tautomerase/MIF superfamily TK78_RS18040 bcd96fee48ce6d7aaa736a982be541e8 79 Gene3D G3DSA:3.30.429.20 1 59 1.4E-18 T 09-03-2017 TK78_RS00985 d30cac32655c0760e346aa88f0310b6e 54 Hamap MF_00236 Sec-independent protein translocase protein TatA [tatA]. 3 54 16.451 T 09-03-2017 IPR006312 Sec-independent protein translocase protein TatA/E GO:0005886|GO:0008565|GO:0009306|GO:0015031|GO:0016021 TK78_RS00985 d30cac32655c0760e346aa88f0310b6e 54 Pfam PF02416 mttA/Hcf106 family 8 51 4.6E-16 T 09-03-2017 IPR003369 Sec-independent protein translocase protein TatA/B/E GO:0008565|GO:0015031 TK78_RS00985 d30cac32655c0760e346aa88f0310b6e 54 TIGRFAM TIGR01411 tatAE: twin arginine-targeting protein translocase, TatA/E family 5 51 7.0E-17 T 09-03-2017 IPR006312 Sec-independent protein translocase protein TatA/E GO:0005886|GO:0008565|GO:0009306|GO:0015031|GO:0016021 TK78_RS11795 3167d9d255c91f9a5de4cf1a5e294702 144 SUPERFAMILY SSF50447 23 64 9.18E-7 T 09-03-2017 IPR009000 Translation protein, beta-barrel domain TK78_RS11795 3167d9d255c91f9a5de4cf1a5e294702 144 Pfam PF01411 tRNA synthetases class II (A) 14 62 6.0E-8 T 09-03-2017 IPR018164 Alanyl-tRNA synthetase, class IIc, N-terminal GO:0000166|GO:0004813|GO:0005524|GO:0006419 KEGG: 00970+6.1.1.7 TK78_RS21720 4d1e0f01f9e56269d8598c8c0fd4ca64 461 PIRSF PIRSF006060 6 460 5.2E-76 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS21720 4d1e0f01f9e56269d8598c8c0fd4ca64 461 Pfam PF13520 Amino acid permease 31 417 2.3E-41 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS09535 6f0aec685256f23f22455927562a92b0 245 Pfam PF03413 Peptidase propeptide and YPEB domain 155 218 3.6E-8 T 09-03-2017 IPR025711 PepSY domain TK78_RS09535 6f0aec685256f23f22455927562a92b0 245 Pfam PF03413 Peptidase propeptide and YPEB domain 76 137 1.7E-13 T 09-03-2017 IPR025711 PepSY domain TK78_RS12135 468e3bdb3cb8917532e196ee42b4dd18 438 ProSitePatterns PS00216 Sugar transport proteins signature 1. 100 116 - T 09-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 TK78_RS12135 468e3bdb3cb8917532e196ee42b4dd18 438 SUPERFAMILY SSF103473 36 420 3.4E-54 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS12135 468e3bdb3cb8917532e196ee42b4dd18 438 Pfam PF07690 Major Facilitator Superfamily 51 354 6.0E-30 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS12135 468e3bdb3cb8917532e196ee42b4dd18 438 Gene3D G3DSA:1.20.1250.20 247 418 2.0E-10 T 09-03-2017 TK78_RS12135 468e3bdb3cb8917532e196ee42b4dd18 438 Gene3D G3DSA:1.20.1250.20 45 224 2.1E-26 T 09-03-2017 TK78_RS30075 a40df1010c1b1d957758c5b74d70ddec 235 Pfam PF01066 CDP-alcohol phosphatidyltransferase 27 91 1.1E-9 T 09-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 TK78_RS30075 a40df1010c1b1d957758c5b74d70ddec 235 ProSitePatterns PS00379 CDP-alcohol phosphatidyltransferases signature. 69 91 - T 09-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 TK78_RS27905 86e7804f07a78d4eb6758df4b8fca6e7 508 PIRSF PIRSF026631 5 491 8.4E-66 T 09-03-2017 IPR014529 Uncharacterised conserved protein UCP026631 TK78_RS27905 86e7804f07a78d4eb6758df4b8fca6e7 508 Pfam PF03703 Bacterial PH domain 410 469 1.5E-6 T 09-03-2017 IPR005182 Domain of unknown function DUF304 TK78_RS27905 86e7804f07a78d4eb6758df4b8fca6e7 508 Pfam PF03703 Bacterial PH domain 72 143 2.3E-11 T 09-03-2017 IPR005182 Domain of unknown function DUF304 TK78_RS22970 1373f2188d55970e5cc55afd4987e068 252 SUPERFAMILY SSF56784 14 236 8.57E-34 T 09-03-2017 IPR023214 HAD-like domain TK78_RS22970 1373f2188d55970e5cc55afd4987e068 252 TIGRFAM TIGR03351 PhnX-like: phosphonatase-like hydrolase 16 235 7.4E-68 T 09-03-2017 IPR022468 Phosphonatase-like hydrolase TK78_RS22970 1373f2188d55970e5cc55afd4987e068 252 Gene3D G3DSA:3.40.50.1000 64 235 9.7E-28 T 09-03-2017 IPR023214 HAD-like domain TK78_RS22970 1373f2188d55970e5cc55afd4987e068 252 Pfam PF13419 Haloacid dehalogenase-like hydrolase 21 202 4.4E-9 T 09-03-2017 IPR023214 HAD-like domain TK78_RS29170 b9fce5275a8221cbe449fca885c5be0d 209 Pfam PF00753 Metallo-beta-lactamase superfamily 25 183 1.8E-22 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS29170 b9fce5275a8221cbe449fca885c5be0d 209 SMART SM00849 24 188 2.8E-38 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS29170 b9fce5275a8221cbe449fca885c5be0d 209 SUPERFAMILY SSF56281 10 201 3.8E-47 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS29170 b9fce5275a8221cbe449fca885c5be0d 209 Gene3D G3DSA:3.60.15.10 24 192 2.5E-46 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS09885 b61b6c078597e09ce9d274ebcd85b53d 166 Pfam PF08239 Bacterial SH3 domain 103 157 1.1E-9 T 09-03-2017 IPR003646 SH3-like domain, bacterial-type TK78_RS28375 a4e71f55016827a9a05752c087e7aef7 121 Pfam PF04341 Protein of unknown function, DUF485 28 114 7.6E-32 T 09-03-2017 IPR007436 Protein of unknown function DUF485 TK78_RS23385 303515d04f0cc79724d41e9eb785abd6 293 Pfam PF09851 Short C-terminal domain 264 290 1.3E-6 T 09-03-2017 IPR018649 SHOCT domain TK78_RS23385 303515d04f0cc79724d41e9eb785abd6 293 Pfam PF14472 Domain of unknown function (DUF4429) 11 103 2.6E-18 T 09-03-2017 IPR027860 Domain of unknown function DUF4429 TK78_RS23385 303515d04f0cc79724d41e9eb785abd6 293 Pfam PF14472 Domain of unknown function (DUF4429) 137 225 3.3E-21 T 09-03-2017 IPR027860 Domain of unknown function DUF4429 TK78_RS05030 0860db642accd06b3a50764049c7a33a 281 SUPERFAMILY SSF161098 7 281 4.58E-71 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS05030 0860db642accd06b3a50764049c7a33a 281 Gene3D G3DSA:1.10.3720.10 6 268 1.5E-67 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS05030 0860db642accd06b3a50764049c7a33a 281 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 93 271 6.3E-18 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS06135 72732f188538ba7a1bb4a0a1f9a93008 158 Gene3D G3DSA:3.40.50.450 42 153 9.6E-8 T 09-03-2017 TK78_RS06135 72732f188538ba7a1bb4a0a1f9a93008 158 SUPERFAMILY SSF102405 1 155 1.83E-14 T 09-03-2017 TK78_RS19525 8c10f0c19a2817882986bcf414d35940 165 Pfam PF13581 Histidine kinase-like ATPase domain 26 131 7.0E-11 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS19525 8c10f0c19a2817882986bcf414d35940 165 SUPERFAMILY SSF55874 51 133 1.95E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS23720 28e06023ec3e726d1183fa2f9a0dcd4a 261 Pfam PF01261 Xylose isomerase-like TIM barrel 20 201 1.2E-29 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS23720 28e06023ec3e726d1183fa2f9a0dcd4a 261 SUPERFAMILY SSF51658 1 251 2.62E-40 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS23720 28e06023ec3e726d1183fa2f9a0dcd4a 261 Gene3D G3DSA:3.20.20.150 1 254 9.4E-53 T 09-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain TK78_RS11710 32146cec11ff9a6f4c991793249875c4 286 Gene3D G3DSA:2.40.10.10 180 232 9.6E-7 T 09-03-2017 TK78_RS11710 32146cec11ff9a6f4c991793249875c4 286 Pfam PF13365 Trypsin-like peptidase domain 67 224 4.0E-10 T 09-03-2017 TK78_RS11710 32146cec11ff9a6f4c991793249875c4 286 SUPERFAMILY SSF50494 9 229 1.1E-15 T 09-03-2017 IPR009003 Peptidase S1, PA clan TK78_RS33230 57b54763d2347f4d58ba5e480384d1cf 350 SUPERFAMILY SSF81345 20 342 1.57E-66 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS33230 57b54763d2347f4d58ba5e480384d1cf 350 Pfam PF01032 FecCD transport family 37 342 5.0E-77 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS33230 57b54763d2347f4d58ba5e480384d1cf 350 Gene3D G3DSA:1.10.3470.10 24 345 2.3E-86 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS16115 b106237fd87731eaa901a93e18c866e0 320 Pfam PF04893 Yip1 domain 156 311 3.0E-14 T 09-03-2017 IPR006977 Yip1 domain GO:0016020 TK78_RS31295 5bc3a7996c9b15bffc0c6f0421dda55a 195 Pfam PF11611 Domain of unknown function (DUF4352) 83 169 2.5E-9 T 09-03-2017 IPR029051 Domain of unknown function DUF4352 TK78_RS31295 5bc3a7996c9b15bffc0c6f0421dda55a 195 Gene3D G3DSA:2.60.40.1240 104 175 4.5E-10 T 09-03-2017 IPR029050 Immunoprotective extracellular, immunoglobulin-like domain TK78_RS34565 bc6e37d90bc2f3787b5a71a59b62218f 199 Pfam PF06197 Protein of unknown function (DUF998) 15 187 3.1E-29 T 09-03-2017 IPR009339 Protein of unknown function DUF998 TK78_RS10390 17ef9a4ce644b13978b6d1ab51a48107 213 Gene3D G3DSA:3.40.50.1820 27 185 1.3E-14 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS10390 17ef9a4ce644b13978b6d1ab51a48107 213 SUPERFAMILY SSF53474 6 209 1.08E-17 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS31185 31845f636497aacd0790752f2efb8474 292 SUPERFAMILY SSF56112 41 160 5.1E-5 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS03170 f228de07cda835dd1e84fe6cf03ea411 309 Pfam PF01061 ABC-2 type transporter 60 267 8.6E-18 T 09-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 TK78_RS02335 7fd481a85022e780ef815267e48b705b 170 PIRSF PIRSF010260 1 169 1.9E-53 T 09-03-2017 IPR014457 Uncharacterised conserved protein UCP010260 TK78_RS02335 7fd481a85022e780ef815267e48b705b 170 Pfam PF09348 Domain of unknown function (DUF1990) 5 161 3.2E-54 T 09-03-2017 IPR018960 Domain of unknown function DUF1990 TK78_RS14605 ddfa200670e1eb37a6b4189d486f4dc1 146 SUPERFAMILY SSF46785 10 137 2.64E-29 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS14605 ddfa200670e1eb37a6b4189d486f4dc1 146 PRINTS PR00598 Bacterial regulatory protein MarR family signature 71 86 1.3E-8 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS14605 ddfa200670e1eb37a6b4189d486f4dc1 146 PRINTS PR00598 Bacterial regulatory protein MarR family signature 120 140 1.3E-8 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS14605 ddfa200670e1eb37a6b4189d486f4dc1 146 PRINTS PR00598 Bacterial regulatory protein MarR family signature 54 70 1.3E-8 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS14605 ddfa200670e1eb37a6b4189d486f4dc1 146 PRINTS PR00598 Bacterial regulatory protein MarR family signature 90 106 1.3E-8 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS14605 ddfa200670e1eb37a6b4189d486f4dc1 146 SMART SM00347 30 130 2.9E-20 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS14605 ddfa200670e1eb37a6b4189d486f4dc1 146 ProSitePatterns PS01117 MarR-type HTH domain signature. 69 103 - T 09-03-2017 IPR023187 Transcriptional regulator MarR-type, conserved site TK78_RS14605 ddfa200670e1eb37a6b4189d486f4dc1 146 Gene3D G3DSA:1.10.10.10 12 136 2.4E-31 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS14605 ddfa200670e1eb37a6b4189d486f4dc1 146 Pfam PF12802 MarR family 37 94 1.2E-14 T 09-03-2017 TK78_RS27015 1fc44a0425cdfc34d920b5a7fffb1ec3 695 TIGRFAM TIGR03061 pip_yhgE_Nterm: YhgE/Pip N-terminal domain 10 172 1.3E-57 T 09-03-2017 IPR017500 Phage infection protein, YhgE, N-terminal TK78_RS27015 1fc44a0425cdfc34d920b5a7fffb1ec3 695 TIGRFAM TIGR03062 pip_yhgE_Cterm: YhgE/Pip C-terminal domain 477 682 8.5E-72 T 09-03-2017 IPR017501 Phage infection protein, YhgE, C-terminal TK78_RS27015 1fc44a0425cdfc34d920b5a7fffb1ec3 695 Pfam PF12698 ABC-2 family transporter protein 480 675 1.9E-16 T 09-03-2017 TK78_RS27015 1fc44a0425cdfc34d920b5a7fffb1ec3 695 TIGRFAM TIGR03057 xxxLxxG_by_4: X-X-X-Leu-X-X-Gly heptad repeats 217 244 3.6E-5 T 09-03-2017 IPR023908 xxxLxxG heptad repeat TK78_RS22720 7c4eadd48a1f548abff442dcc4c34187 266 Pfam PF06182 ABC-2 family transporter protein 42 261 1.1E-15 T 09-03-2017 IPR010390 Protein of unknown function DUF990 TK78_RS18980 ca52db103749046a9527e5778063a39c 170 SUPERFAMILY SSF69635 10 135 8.37E-32 T 09-03-2017 TK78_RS18980 ca52db103749046a9527e5778063a39c 170 Gene3D G3DSA:3.30.1460.10 12 144 2.1E-15 T 09-03-2017 TK78_RS18980 ca52db103749046a9527e5778063a39c 170 Pfam PF10722 Putative bacterial sensory transduction regulator 12 133 2.9E-18 T 09-03-2017 IPR019660 Putative sensory transduction regulator YbjN TK78_RS04415 7bbd8321f673d55dc49d20ee071671ac 145 SUPERFAMILY SSF56235 2 141 6.56E-21 T 09-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal TK78_RS04415 7bbd8321f673d55dc49d20ee071671ac 145 Pfam PF01019 Gamma-glutamyltranspeptidase 2 137 1.6E-19 T 09-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 TK78_RS05510 ee74e1c8883baddebf5964bf594e0c53 309 SUPERFAMILY SSF161098 101 289 6.93E-29 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS05510 ee74e1c8883baddebf5964bf594e0c53 309 Gene3D G3DSA:1.10.3720.10 101 296 3.8E-23 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS05510 ee74e1c8883baddebf5964bf594e0c53 309 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 125 289 1.6E-17 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS09145 440ceef3224bbf6b57b261d57b5c52b5 513 Pfam PF04984 Phage tail sheath protein 1 502 6.1E-96 T 09-03-2017 IPR007067 Tail sheath protein TK78_RS14610 d9846c57bbdb67268e834e1ffb0759ee 77 SUPERFAMILY SSF47598 6 39 2.78E-6 T 09-03-2017 IPR010985 Ribbon-helix-helix GO:0006355 TK78_RS31110 876ce734c58797f2a3277640fab73c76 232 SMART SM00873 64 220 2.9E-18 T 09-03-2017 IPR005146 B3/B4 tRNA-binding domain GO:0003723|GO:0004826 KEGG: 00970+6.1.1.20 TK78_RS31110 876ce734c58797f2a3277640fab73c76 232 Gene3D G3DSA:3.50.40.10 62 201 7.2E-17 T 09-03-2017 IPR020825 Phenylalanyl-tRNA synthetase, B3/B4 Reactome: R-HSA-379716 TK78_RS31110 876ce734c58797f2a3277640fab73c76 232 Pfam PF03483 B3/4 domain 66 203 7.5E-23 T 09-03-2017 IPR005146 B3/B4 tRNA-binding domain GO:0003723|GO:0004826 KEGG: 00970+6.1.1.20 TK78_RS31110 876ce734c58797f2a3277640fab73c76 232 SUPERFAMILY SSF56037 53 218 1.26E-30 T 09-03-2017 IPR020825 Phenylalanyl-tRNA synthetase, B3/B4 Reactome: R-HSA-379716 TK78_RS24970 a9e516863446074c2dbe976f47483480 275 SMART SM00530 19 74 3.0E-13 T 09-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 TK78_RS24970 a9e516863446074c2dbe976f47483480 275 Gene3D G3DSA:1.10.260.40 9 69 1.2E-15 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS24970 a9e516863446074c2dbe976f47483480 275 SUPERFAMILY SSF47413 14 69 7.51E-13 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS24970 a9e516863446074c2dbe976f47483480 275 Pfam PF13560 Helix-turn-helix domain 16 70 1.7E-16 T 09-03-2017 TK78_RS23875 4af30dc01b6ae03809e133ba140dd58c 191 SMART SM00347 55 159 8.3E-4 T 09-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 TK78_RS23875 4af30dc01b6ae03809e133ba140dd58c 191 Gene3D G3DSA:1.10.10.10 34 174 2.4E-21 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS23875 4af30dc01b6ae03809e133ba140dd58c 191 Pfam PF12802 MarR family 60 122 1.8E-7 T 09-03-2017 TK78_RS23875 4af30dc01b6ae03809e133ba140dd58c 191 SUPERFAMILY SSF46785 39 174 9.79E-19 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS21525 fedb8f62d51f025f9cf839c9f40c1acf 242 SUPERFAMILY SSF89392 42 227 3.41E-6 T 09-03-2017 IPR029046 Lipoprotein localisation LolA/LolB/LppX TK78_RS23575 9fa884021621f89f4b8c077c91e59c50 128 Pfam PF03995 Peptidase inhibitor family I36 29 105 5.1E-16 T 09-03-2017 TK78_RS29040 f83cb0a082f62d56dce300885127d6b2 96 Pfam PF05360 yiaA/B two helix domain 15 67 5.8E-18 T 09-03-2017 IPR008024 YiaAB two helix TK78_RS30570 d06b884b5971fbc08e4447eb38a018ea 202 Pfam PF04186 FxsA cytoplasmic membrane protein 23 142 2.8E-30 T 09-03-2017 IPR007313 FxsA cytoplasmic membrane protein GO:0016020 TK78_RS32965 a34d4be6d8412c50baad7284a2ddcb57 344 Gene3D G3DSA:3.40.50.720 33 315 4.4E-17 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS32965 a34d4be6d8412c50baad7284a2ddcb57 344 SUPERFAMILY SSF51735 33 326 2.99E-25 T 09-03-2017 IPR016040 NAD(P)-binding domain TK78_RS32965 a34d4be6d8412c50baad7284a2ddcb57 344 Pfam PF01370 NAD dependent epimerase/dehydratase family 34 223 8.3E-10 T 09-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 TK78_RS27220 40a6aaddf4f67bde1019bd61bce028d7 280 Pfam PF01061 ABC-2 type transporter 55 240 7.9E-11 T 09-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 TK78_RS14150 5449afb7938e892d5f338686b46cf2b5 292 Pfam PF04655 Aminoglycoside/hydroxyurea antibiotic resistance kinase 33 262 5.2E-27 T 09-03-2017 IPR006748 Aminoglycoside/hydroxyurea antibiotic resistance kinase GO:0006468|GO:0016773|GO:0019748 TK78_RS14150 5449afb7938e892d5f338686b46cf2b5 292 Gene3D G3DSA:3.90.1200.10 120 232 5.7E-10 T 09-03-2017 TK78_RS14150 5449afb7938e892d5f338686b46cf2b5 292 SUPERFAMILY SSF56112 22 271 5.1E-30 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS05340 74b8de366f03044fc9e3ee8053f77988 160 Pfam PF04306 Protein of unknown function (DUF456) 21 156 1.1E-25 T 09-03-2017 IPR007403 Protein of unknown function DUF456 TK78_RS32620 00118015f5e03e82580d2fda95460269 238 Gene3D G3DSA:2.60.120.10 28 95 1.8E-8 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS32620 00118015f5e03e82580d2fda95460269 238 SUPERFAMILY SSF51182 29 132 2.23E-12 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS23445 f7de5373579e06930b7acbb825a18f37 215 Pfam PF02698 DUF218 domain 28 146 1.0E-19 T 09-03-2017 IPR003848 Domain of unknown function DUF218 TK78_RS23445 f7de5373579e06930b7acbb825a18f37 215 Gene3D G3DSA:3.40.50.620 17 152 6.7E-40 T 09-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TK78_RS15370 e210b694b79acf286fdd12553aed0a4d 274 Gene3D G3DSA:1.10.3290.10 47 253 8.9E-6 T 09-03-2017 IPR003812 Fido domain TK78_RS31065 e66dbc3ab53f55bb130c9eb2203c5b0f 254 SUPERFAMILY SSF53474 10 247 1.02E-55 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS31065 e66dbc3ab53f55bb130c9eb2203c5b0f 254 SMART SM00824 Thioesterase 26 247 1.5E-6 T 09-03-2017 IPR020802 Polyketide synthase, thioesterase domain GO:0009058|GO:0016788 TK78_RS31065 e66dbc3ab53f55bb130c9eb2203c5b0f 254 Pfam PF00975 Thioesterase domain 24 245 1.9E-56 T 09-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 TK78_RS31065 e66dbc3ab53f55bb130c9eb2203c5b0f 254 Gene3D G3DSA:3.40.50.1820 14 252 9.3E-46 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS09950 4bf276d50cc847af33ae8117757d3c6f 139 Pfam PF05331 Protein of unknown function (DUF742) 20 139 2.6E-40 T 09-03-2017 IPR007995 Protein of unknown function DUF742 TK78_RS01315 bcfd0038a7d919c6c276babb9a265f14 75 Pfam PF17196 Protein of unknown function (DUF5133) 1 64 3.0E-29 T 09-03-2017 IPR033457 Protein of unknown function DUF5133 TK78_RS03480 5365de246909af7dd26317202fa76052 391 Pfam PF11887 Cholesterol uptake porter CUP1 of Mce4, putative 159 277 2.5E-7 T 09-03-2017 IPR024516 Mammalian cell entry, C-terminal TK78_RS03480 5365de246909af7dd26317202fa76052 391 Pfam PF02470 MlaD protein 32 106 1.9E-14 T 09-03-2017 IPR003399 Mce/MlaD TK78_RS03480 5365de246909af7dd26317202fa76052 391 TIGRFAM TIGR00996 Mtu_fam_mce: virulence factor Mce family protein 10 293 7.0E-63 T 09-03-2017 IPR005693 Virulence factor Mce protein TK78_RS17025 7f38d3e67420320dfe1012e0952c705b 302 Pfam PF12679 ABC-2 family transporter protein 96 293 7.3E-7 T 09-03-2017 IPR032688 ABC-2 family transporter protein GO:0006810 TK78_RS09630 216c21ca2e08f6a35a44a70f7fddcf94 249 PIRSF PIRSF006648 2 249 3.5E-42 T 09-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 TK78_RS09630 216c21ca2e08f6a35a44a70f7fddcf94 249 Pfam PF01061 ABC-2 type transporter 9 212 3.2E-28 T 09-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 TK78_RS18020 21ca13c743280ed8a0f733c9c204654a 599 Pfam PF01186 Lysyl oxidase 445 581 2.1E-16 T 09-03-2017 IPR001695 Lysyl oxidase GO:0005507|GO:0016641|GO:0055114 Reactome: R-HSA-1566948|Reactome: R-HSA-2243919 TK78_RS02870 7af72d3d2253f106abe1f8fa591dce98 302 Pfam PF10708 Protein of unknown function (DUF2510) 4 39 3.6E-11 T 09-03-2017 IPR018929 Domain of unknown function DUF2510 TK78_RS16195 a3561917da2e4069bceb908cb3fe22b3 379 Pfam PF13556 PucR C-terminal helix-turn-helix domain 320 374 1.3E-15 T 09-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain TK78_RS27665 89bdc7deab3dcdeb80c64d0592ff54d0 282 Pfam PF08241 Methyltransferase domain 89 181 5.9E-18 T 09-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 TK78_RS27665 89bdc7deab3dcdeb80c64d0592ff54d0 282 Gene3D G3DSA:3.40.50.150 38 270 8.9E-30 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS27665 89bdc7deab3dcdeb80c64d0592ff54d0 282 SUPERFAMILY SSF53335 38 259 1.75E-32 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS10460 3a14913f3640569888a5e95141445d20 107 SUPERFAMILY SSF103481 6 105 7.32E-18 T 09-03-2017 TK78_RS10460 3a14913f3640569888a5e95141445d20 107 Pfam PF00893 Small Multidrug Resistance protein 1 93 8.5E-25 T 09-03-2017 IPR000390 Small multidrug resistance protein family GO:0016021 TK78_RS06890 616b766bf326be195b56ec8cac7608b7 257 Pfam PF12502 Protein of unknown function (DUF3710) 51 224 1.5E-61 T 09-03-2017 IPR022183 Protein of unknown function DUF3710 TK78_RS01645 bdf39cf87d75f6347791412426c0b3c9 382 SUPERFAMILY SSF55729 173 328 2.52E-10 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS01645 bdf39cf87d75f6347791412426c0b3c9 382 Pfam PF13480 Acetyltransferase (GNAT) domain 175 319 2.4E-20 T 09-03-2017 TK78_RS21050 07d840b80ee128cf53050ee381ee123c 253 TIGRFAM TIGR02454 ECF_T_CbiQ: cobalt ECF transporter T component CbiQ 21 214 2.4E-48 T 09-03-2017 IPR012809 Cobalt ECF transporter T component CbiQ GO:0005887|GO:0006824|GO:0043190 TK78_RS21050 07d840b80ee128cf53050ee381ee123c 253 Pfam PF02361 Cobalt transport protein 15 218 2.4E-30 T 09-03-2017 IPR003339 ABC/ECF transporter, transmembrane component TK78_RS04385 6480a5531e976a6224db6895e559a81a 194 Pfam PF01169 Uncharacterized protein family UPF0016 9 80 3.6E-16 T 09-03-2017 IPR001727 Gdt1 family GO:0032472 TK78_RS04385 6480a5531e976a6224db6895e559a81a 194 Pfam PF01169 Uncharacterized protein family UPF0016 111 183 6.3E-17 T 09-03-2017 IPR001727 Gdt1 family GO:0032472 TK78_RS28275 5b00747ee68de876acadfb805d4bb62a 296 Pfam PF04228 Putative neutral zinc metallopeptidase 12 295 1.6E-82 T 09-03-2017 IPR007343 Uncharacterised protein family, zinc metallopeptidase putative TK78_RS28275 5b00747ee68de876acadfb805d4bb62a 296 SUPERFAMILY SSF55486 160 242 3.3E-6 T 09-03-2017 TK78_RS11240 025bac978efa1b0fcb84ea8fbdf1a78e 237 Pfam PF04012 PspA/IM30 family 6 234 3.8E-38 T 09-03-2017 IPR007157 PspA/IM30 TK78_RS11240 025bac978efa1b0fcb84ea8fbdf1a78e 237 Gene3D G3DSA:1.10.357.10 6 71 3.3E-4 T 09-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 TK78_RS06490 947986b4d8cf1afe1a2322778546be99 150 TIGRFAM TIGR03618 Rv1155_F420: PPOX class probable F420-dependent enzyme 18 145 2.3E-24 T 09-03-2017 IPR019920 F420-binding domain, putative TK78_RS06490 947986b4d8cf1afe1a2322778546be99 150 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 12 93 1.8E-12 T 09-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS06490 947986b4d8cf1afe1a2322778546be99 150 SUPERFAMILY SSF50475 13 145 6.73E-24 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS06490 947986b4d8cf1afe1a2322778546be99 150 Gene3D G3DSA:2.30.110.10 11 146 2.1E-21 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS13425 828d12f09b678ed8ff0f79a537529bd2 138 Pfam PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 38 137 2.1E-30 T 09-03-2017 IPR000440 NADH:ubiquinone/plastoquinone oxidoreductase, chain 3 GO:0008137|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS13425 828d12f09b678ed8ff0f79a537529bd2 138 Hamap MF_01394 NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic [ndhC]. 19 138 16.492 T 09-03-2017 IPR023043 NAD(P)H-quinone oxidoreductase subunit 3, bacterial/plastid GO:0016651|GO:0055114 TK78_RS20305 e4b5c2908ff40a61659510e64bf968b1 419 SUPERFAMILY SSF53474 240 404 2.13E-19 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS20305 e4b5c2908ff40a61659510e64bf968b1 419 SUPERFAMILY SSF53474 155 204 2.13E-19 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS20305 e4b5c2908ff40a61659510e64bf968b1 419 Pfam PF03403 Platelet-activating factor acetylhydrolase, isoform II 157 201 7.7E-6 T 09-03-2017 IPR005065 Platelet-activating factor acetylhydrolase GO:0003847|GO:0016042 KEGG: 00565+3.1.1.47 TK78_RS20305 e4b5c2908ff40a61659510e64bf968b1 419 Gene3D G3DSA:3.40.50.1820 155 202 1.6E-53 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS20305 e4b5c2908ff40a61659510e64bf968b1 419 Gene3D G3DSA:3.40.50.1820 236 415 1.6E-53 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS20305 e4b5c2908ff40a61659510e64bf968b1 419 Gene3D G3DSA:3.40.50.1820 63 108 1.6E-53 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS30090 52478b1e16b2c270c0090cac6a88a684 182 Gene3D G3DSA:1.20.1440.20 20 140 2.4E-7 T 09-03-2017 IPR023353 LemA-like domain TK78_RS09125 816fe8cdc05231855d617d56626345bc 234 Pfam PF14065 Protein of unknown function (DUF4255) 4 180 2.2E-40 T 09-03-2017 IPR025351 Protein of unknown function DUF4255 TK78_RS17585 cab453bf836338c1deaa81092e0fe43f 165 TIGRFAM TIGR02159 PA_CoA_Oxy4: phenylacetate-CoA oxygenase, PaaJ subunit 18 164 3.2E-55 T 09-03-2017 IPR011883 Phenylacetate-CoA oxygenase, PaaJ subunit TK78_RS17585 cab453bf836338c1deaa81092e0fe43f 165 Pfam PF01883 Domain of unknown function DUF59 16 83 1.9E-14 T 09-03-2017 IPR002744 Domain of unknown function DUF59 TK78_RS17585 cab453bf836338c1deaa81092e0fe43f 165 SUPERFAMILY SSF117916 4 101 7.19E-22 T 09-03-2017 TK78_RS02400 857aa2abf6920fe483c605b7b6d3ebc4 234 Pfam PF11575 FhuF 2Fe-2S C-terminal domain 203 222 1.2E-6 T 09-03-2017 IPR024726 Ferric iron reductase, C-terminal GO:0051537 TK78_RS22140 40b32fd9d889b79b22bf3d8bb7c6be76 228 Gene3D G3DSA:3.40.50.1000 70 222 6.5E-15 T 09-03-2017 IPR023214 HAD-like domain TK78_RS22140 40b32fd9d889b79b22bf3d8bb7c6be76 228 Pfam PF13419 Haloacid dehalogenase-like hydrolase 11 193 2.6E-9 T 09-03-2017 IPR023214 HAD-like domain TK78_RS22140 40b32fd9d889b79b22bf3d8bb7c6be76 228 SUPERFAMILY SSF56784 9 222 1.6E-28 T 09-03-2017 IPR023214 HAD-like domain TK78_RS15610 5f2e22e63a3e546545bf9912c489c148 255 Pfam PF05988 Bacterial protein of unknown function (DUF899) 16 223 9.5E-62 T 09-03-2017 IPR010296 Protein of unknown function DUF899, thioredoxin-like TK78_RS30465 ebdbe247c731a93637e951ea9e2ab0b3 214 Pfam PF04973 Nicotinamide mononucleotide transporter 21 201 2.3E-44 T 09-03-2017 IPR006419 Nicotinamide mononucleotide transporter PnuC GO:0016020|GO:0034257|GO:0034258 TK78_RS17935 c57243921284d42b4c3f156208c5bea6 705 SUPERFAMILY SSF117892 57 175 6.02E-10 T 09-03-2017 IPR001107 Band 7 domain TK78_RS17935 c57243921284d42b4c3f156208c5bea6 705 Pfam PF01145 SPFH domain / Band 7 family 32 228 1.2E-5 T 09-03-2017 IPR001107 Band 7 domain TK78_RS25985 c22662f814976e5009e1e752d6c2bd31 278 Pfam PF01784 NIF3 (NGG1p interacting factor 3) 6 247 2.9E-67 T 09-03-2017 IPR002678 GTP cyclohydrolase 1 type 2/Nif3 TK78_RS25985 c22662f814976e5009e1e752d6c2bd31 278 Gene3D G3DSA:3.40.1390.30 3 114 8.2E-41 T 09-03-2017 TK78_RS25985 c22662f814976e5009e1e752d6c2bd31 278 SUPERFAMILY SSF102705 3 270 1.7E-79 T 09-03-2017 IPR002678 GTP cyclohydrolase 1 type 2/Nif3 TK78_RS25985 c22662f814976e5009e1e752d6c2bd31 278 Gene3D G3DSA:3.40.1390.30 115 220 1.6E-31 T 09-03-2017 TK78_RS25985 c22662f814976e5009e1e752d6c2bd31 278 TIGRFAM TIGR00486 YbgI_SA1388: dinuclear metal center protein, YbgI/SA1388 family 4 236 1.9E-44 T 09-03-2017 IPR002678 GTP cyclohydrolase 1 type 2/Nif3 TK78_RS21605 d54af073db2b1e6270d38af35488ccb7 843 Pfam PF12704 MacB-like periplasmic core domain 17 230 4.3E-16 T 09-03-2017 IPR025857 MacB-like periplasmic core domain TK78_RS21605 d54af073db2b1e6270d38af35488ccb7 843 Pfam PF12704 MacB-like periplasmic core domain 489 678 2.4E-9 T 09-03-2017 IPR025857 MacB-like periplasmic core domain TK78_RS21605 d54af073db2b1e6270d38af35488ccb7 843 Pfam PF02687 FtsX-like permease family 267 387 5.6E-23 T 09-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 TK78_RS21605 d54af073db2b1e6270d38af35488ccb7 843 Pfam PF02687 FtsX-like permease family 719 835 4.2E-22 T 09-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 TK78_RS04715 721a5c23a559b03b84ac699cf794fb64 234 Pfam PF07335 Fungal chitosanase of glycosyl hydrolase group 75 89 218 2.2E-24 T 09-03-2017 IPR009939 Fungal chitosanase KEGG: 00520+3.2.1.132 TK78_RS20120 fe82093083b1ede5712f4d6df65a263a 479 Pfam PF10935 Protein of unknown function (DUF2637) 16 170 8.1E-39 T 09-03-2017 IPR021235 Protein of unknown function DUF2637 TK78_RS15455 9774bac4a21185ea50c7ce2f41e0adfe 133 Hamap MF_01479 Transcriptional regulator WhiB [whiB]. 18 91 18.862 T 09-03-2017 IPR003482 Transcription factor WhiB TK78_RS15455 9774bac4a21185ea50c7ce2f41e0adfe 133 Pfam PF02467 Transcription factor WhiB 24 86 1.4E-24 T 09-03-2017 IPR003482 Transcription factor WhiB TK78_RS00455 e4db9a215d8274ca6c5ed6cad246b42a 246 Pfam PF12138 Spherulation-specific family 4 2 240 3.1E-36 T 09-03-2017 IPR021986 Spherulation-specific family 4 TK78_RS26270 b579312f3cd540a7cda9a9ff048b7780 242 Gene3D G3DSA:1.20.1260.10 58 236 2.8E-58 T 09-03-2017 IPR012347 Ferritin-related TK78_RS26270 b579312f3cd540a7cda9a9ff048b7780 242 Pfam PF03713 Domain of unknown function (DUF305) 64 233 1.0E-44 T 09-03-2017 IPR005183 Domain of unknown function DUF305 TK78_RS11530 39588f190e5f4b52fb8e56cfcd7f1b0e 397 Pfam PF06224 Winged helix DNA-binding domain 48 378 2.9E-48 T 09-03-2017 IPR009351 Protein of unknown function DUF1006 TK78_RS21410 dc83516c9dc02aa5dd3218589784feea 422 Gene3D G3DSA:1.10.630.10 21 419 3.8E-81 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS21410 dc83516c9dc02aa5dd3218589784feea 422 PRINTS PR00359 B-class P450 signature 213 235 1.9E-13 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS21410 dc83516c9dc02aa5dd3218589784feea 422 PRINTS PR00359 B-class P450 signature 158 174 1.9E-13 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS21410 dc83516c9dc02aa5dd3218589784feea 422 PRINTS PR00359 B-class P450 signature 309 336 1.9E-13 T 09-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 TK78_RS21410 dc83516c9dc02aa5dd3218589784feea 422 SUPERFAMILY SSF48264 18 419 1.7E-55 T 09-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 TK78_RS29050 1d0f9a174587ef069e5a41b362a2cda6 153 SUPERFAMILY SSF54637 11 150 1.7E-38 T 09-03-2017 IPR029069 HotDog domain TK78_RS29050 1d0f9a174587ef069e5a41b362a2cda6 153 Gene3D G3DSA:3.10.129.10 14 149 6.0E-37 T 09-03-2017 IPR029069 HotDog domain TK78_RS29050 1d0f9a174587ef069e5a41b362a2cda6 153 Pfam PF01575 MaoC like domain 17 133 1.8E-27 T 09-03-2017 IPR002539 MaoC-like domain TK78_RS02255 2ebb6e9aff76306cdf7a5d23c01e7e29 283 Pfam PF01522 Polysaccharide deacetylase 97 214 1.2E-32 T 09-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 TK78_RS02255 2ebb6e9aff76306cdf7a5d23c01e7e29 283 SUPERFAMILY SSF88713 97 277 8.45E-57 T 09-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 TK78_RS02255 2ebb6e9aff76306cdf7a5d23c01e7e29 283 Gene3D G3DSA:3.20.20.370 98 278 1.8E-57 T 09-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 TK78_RS17195 6778487ab359bc6cd78bfa9e940c64c5 284 Gene3D G3DSA:3.40.50.1820 4 282 2.4E-36 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS17195 6778487ab359bc6cd78bfa9e940c64c5 284 Pfam PF00561 alpha/beta hydrolase fold 25 145 2.3E-19 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS17195 6778487ab359bc6cd78bfa9e940c64c5 284 SUPERFAMILY SSF53474 214 283 1.88E-36 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS17195 6778487ab359bc6cd78bfa9e940c64c5 284 SUPERFAMILY SSF53474 5 130 1.88E-36 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS06140 7489a23f02290a36143a72aeb6c047c6 33 Pfam PF13613 Helix-turn-helix of DDE superfamily endonuclease 1 33 9.3E-12 T 09-03-2017 IPR027805 Transposase, Helix-turn-helix domain TK78_RS19175 a03cbe94fa4cdd8df779937cb6d276c0 425 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 238 275 - T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS19175 a03cbe94fa4cdd8df779937cb6d276c0 425 SUPERFAMILY SSF53383 9 418 1.33E-112 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS19175 a03cbe94fa4cdd8df779937cb6d276c0 425 PIRSF PIRSF000521 23 420 8.1E-38 T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS19175 a03cbe94fa4cdd8df779937cb6d276c0 425 Gene3D G3DSA:3.40.640.10 59 326 2.2E-78 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS19175 a03cbe94fa4cdd8df779937cb6d276c0 425 Gene3D G3DSA:3.90.1150.10 329 419 6.0E-30 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS19175 a03cbe94fa4cdd8df779937cb6d276c0 425 Gene3D G3DSA:3.90.1150.10 8 58 6.0E-30 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS19175 a03cbe94fa4cdd8df779937cb6d276c0 425 Pfam PF00202 Aminotransferase class-III 24 417 4.3E-98 T 09-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TK78_RS10365 cc19671cf18a2b4893dc06d058db95af 331 SUPERFAMILY SSF48452 19 110 7.59E-10 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS10365 cc19671cf18a2b4893dc06d058db95af 331 Gene3D G3DSA:1.25.40.10 21 110 5.6E-10 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS02230 28b5f3291874f4598c47235f56f43fff 187 PRINTS PR01217 Proline rich extensin signature 101 126 3.5E-15 T 09-03-2017 TK78_RS02230 28b5f3291874f4598c47235f56f43fff 187 PRINTS PR01217 Proline rich extensin signature 77 94 3.5E-15 T 09-03-2017 TK78_RS02230 28b5f3291874f4598c47235f56f43fff 187 PRINTS PR01217 Proline rich extensin signature 60 76 3.5E-15 T 09-03-2017 TK78_RS30515 23cbac6218adb5e5d1ce3af49d79fb4c 455 Pfam PF13529 Peptidase_C39 like family 242 393 6.6E-28 T 09-03-2017 TK78_RS23135 4c579699ce243f5369b1c3437d27a6d9 444 Gene3D G3DSA:3.40.50.300 26 228 6.9E-17 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS23135 4c579699ce243f5369b1c3437d27a6d9 444 Pfam PF13245 Part of AAA domain 23 87 4.0E-10 T 09-03-2017 TK78_RS23135 4c579699ce243f5369b1c3437d27a6d9 444 SUPERFAMILY SSF52540 28 395 2.17E-22 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS11620 5b1e1e573b7e294241166db9060a1251 314 Pfam PF00482 Type II secretion system (T2SS), protein F 147 271 8.5E-19 T 09-03-2017 IPR018076 Type II secretion system F domain TK78_RS01045 9a2219b936184ec4ae1027fc127b2d14 464 Gene3D G3DSA:1.10.443.10 240 436 4.8E-17 T 09-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 TK78_RS01045 9a2219b936184ec4ae1027fc127b2d14 464 SUPERFAMILY SSF56349 168 436 4.71E-22 T 09-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 TK78_RS20370 f999d7844ffc5b6f3f45e040c14d71a3 278 Pfam PF01551 Peptidase family M23 67 148 4.5E-21 T 09-03-2017 IPR016047 Peptidase M23 TK78_RS20370 f999d7844ffc5b6f3f45e040c14d71a3 278 SUPERFAMILY SSF51261 66 153 1.99E-27 T 09-03-2017 IPR011055 Duplicated hybrid motif TK78_RS20370 f999d7844ffc5b6f3f45e040c14d71a3 278 Gene3D G3DSA:2.70.70.10 32 148 1.2E-26 T 09-03-2017 TK78_RS26325 97ef6e4e7e4c24fef17036d6d95f4a9b 499 Pfam PF07690 Major Facilitator Superfamily 13 409 1.1E-49 T 09-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TK78_RS26325 97ef6e4e7e4c24fef17036d6d95f4a9b 499 Gene3D G3DSA:1.20.1250.20 253 423 1.0E-25 T 09-03-2017 TK78_RS26325 97ef6e4e7e4c24fef17036d6d95f4a9b 499 Gene3D G3DSA:1.20.1250.20 470 495 1.0E-25 T 09-03-2017 TK78_RS26325 97ef6e4e7e4c24fef17036d6d95f4a9b 499 Gene3D G3DSA:1.20.1250.20 10 185 8.7E-30 T 09-03-2017 TK78_RS26325 97ef6e4e7e4c24fef17036d6d95f4a9b 499 SUPERFAMILY SSF103473 4 196 5.36E-67 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS26325 97ef6e4e7e4c24fef17036d6d95f4a9b 499 SUPERFAMILY SSF103473 463 492 5.36E-67 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS26325 97ef6e4e7e4c24fef17036d6d95f4a9b 499 SUPERFAMILY SSF103473 247 419 5.36E-67 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS26325 97ef6e4e7e4c24fef17036d6d95f4a9b 499 PRINTS PR01036 Tetracycline resistance protein TetB signature 400 419 4.3E-15 T 09-03-2017 TK78_RS26325 97ef6e4e7e4c24fef17036d6d95f4a9b 499 PRINTS PR01036 Tetracycline resistance protein TetB signature 12 36 4.3E-15 T 09-03-2017 TK78_RS26325 97ef6e4e7e4c24fef17036d6d95f4a9b 499 PRINTS PR01036 Tetracycline resistance protein TetB signature 103 123 4.3E-15 T 09-03-2017 TK78_RS26325 97ef6e4e7e4c24fef17036d6d95f4a9b 499 PRINTS PR01036 Tetracycline resistance protein TetB signature 337 357 4.3E-15 T 09-03-2017 TK78_RS26325 97ef6e4e7e4c24fef17036d6d95f4a9b 499 PRINTS PR01036 Tetracycline resistance protein TetB signature 133 157 4.3E-15 T 09-03-2017 TK78_RS17520 b49c52e6e325a6fcee1149619965471c 469 Pfam PF01098 Cell cycle protein 82 448 5.3E-77 T 09-03-2017 IPR001182 Cell cycle protein FtsW/RodA GO:0016021|GO:0051301 TK78_RS30935 68e2042c290e76f926318aa6d3c638a4 241 Pfam PF12900 Pyridoxamine 5'-phosphate oxidase 46 192 4.8E-49 T 09-03-2017 IPR024747 Pyridoxamine 5'-phosphate oxidase-related TK78_RS30935 68e2042c290e76f926318aa6d3c638a4 241 Gene3D G3DSA:2.30.110.10 25 213 6.4E-76 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS30935 68e2042c290e76f926318aa6d3c638a4 241 SUPERFAMILY SSF50475 27 213 5.11E-61 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS00085 dd55ed8b2bc3164598adb428efd85293 72 SUPERFAMILY SSF55464 1 72 7.32E-8 T 09-03-2017 TK78_RS00085 dd55ed8b2bc3164598adb428efd85293 72 Pfam PF08751 TrwC relaxase 1 69 5.3E-10 T 09-03-2017 IPR014862 TrwC relaxase TK78_RS04135 c7634028829ac0ab7da82d279f854851 447 SUPERFAMILY SSF53187 14 206 1.89E-52 T 09-03-2017 TK78_RS04135 c7634028829ac0ab7da82d279f854851 447 SUPERFAMILY SSF53187 357 445 1.89E-52 T 09-03-2017 TK78_RS04135 c7634028829ac0ab7da82d279f854851 447 ProSitePatterns PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 85 94 - T 09-03-2017 IPR001261 ArgE/DapE/ACY1/CPG2/YscS, conserved site GO:0006508|GO:0008237 TK78_RS04135 c7634028829ac0ab7da82d279f854851 447 Gene3D G3DSA:3.40.630.10 15 215 3.2E-55 T 09-03-2017 TK78_RS04135 c7634028829ac0ab7da82d279f854851 447 Gene3D G3DSA:3.40.630.10 382 445 3.2E-55 T 09-03-2017 TK78_RS04135 c7634028829ac0ab7da82d279f854851 447 Gene3D G3DSA:3.30.70.360 297 333 8.5E-21 T 09-03-2017 IPR011650 Peptidase M20, dimerisation domain TK78_RS04135 c7634028829ac0ab7da82d279f854851 447 Gene3D G3DSA:3.30.70.360 216 255 8.5E-21 T 09-03-2017 IPR011650 Peptidase M20, dimerisation domain TK78_RS04135 c7634028829ac0ab7da82d279f854851 447 Pfam PF01546 Peptidase family M20/M25/M40 86 445 1.2E-37 T 09-03-2017 IPR002933 Peptidase M20 GO:0008152|GO:0016787 TK78_RS04135 c7634028829ac0ab7da82d279f854851 447 SUPERFAMILY SSF55031 296 334 4.57E-9 T 09-03-2017 IPR011650 Peptidase M20, dimerisation domain TK78_RS04135 c7634028829ac0ab7da82d279f854851 447 SUPERFAMILY SSF55031 206 248 4.57E-9 T 09-03-2017 IPR011650 Peptidase M20, dimerisation domain TK78_RS04135 c7634028829ac0ab7da82d279f854851 447 Pfam PF07687 Peptidase dimerisation domain 204 333 9.4E-14 T 09-03-2017 IPR011650 Peptidase M20, dimerisation domain TK78_RS34235 e60826e6c121287fb8a31de69fd9c738 234 Pfam PF14014 Protein of unknown function (DUF4230) 70 227 1.5E-29 T 09-03-2017 IPR025324 Protein of unknown function DUF4230 TK78_RS03530 46de162390b8675ee4537b42b24c2f09 404 Pfam PF13556 PucR C-terminal helix-turn-helix domain 334 392 7.2E-14 T 09-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain TK78_RS20105 41343475d177ab9b541f99e83c14b65f 115 Gene3D G3DSA:3.30.70.900 10 110 1.4E-32 T 09-03-2017 TK78_RS20105 41343475d177ab9b541f99e83c14b65f 115 SUPERFAMILY SSF54909 10 108 3.58E-22 T 09-03-2017 IPR011008 Dimeric alpha-beta barrel TK78_RS20105 41343475d177ab9b541f99e83c14b65f 115 Pfam PF03992 Antibiotic biosynthesis monooxygenase 13 85 3.3E-14 T 09-03-2017 IPR007138 Antibiotic biosynthesis monooxygenase domain TK78_RS27985 018291733da7a16276e53e3421e7a40d 393 SUPERFAMILY SSF101960 38 390 7.45E-91 T 09-03-2017 TK78_RS27985 018291733da7a16276e53e3421e7a40d 393 Pfam PF01458 Uncharacterized protein family (UPF0051) 143 364 1.1E-70 T 09-03-2017 IPR000825 SUF system FeS cluster assembly, SufBD GO:0016226 TK78_RS27985 018291733da7a16276e53e3421e7a40d 393 TIGRFAM TIGR01981 sufD: FeS assembly protein SufD 112 381 6.4E-74 T 09-03-2017 IPR011542 SUF system FeS cluster assembly, SufD GO:0016226 TK78_RS01820 4fcba13e678caf744f61beddf2da7a3f 330 Pfam PF02653 Branched-chain amino acid transport system / permease component 40 305 3.4E-43 T 09-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 TK78_RS32155 0d60bb4d942a7054f028f44901dd15b4 344 SUPERFAMILY SSF81345 13 338 1.14E-66 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS32155 0d60bb4d942a7054f028f44901dd15b4 344 Gene3D G3DSA:1.10.3470.10 17 342 1.1E-82 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS32155 0d60bb4d942a7054f028f44901dd15b4 344 Pfam PF01032 FecCD transport family 31 338 9.1E-73 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS33060 d7e484e86fd25fea59039ce9501d3678 119 Pfam PF06803 Protein of unknown function (DUF1232) 45 72 6.5E-5 T 09-03-2017 IPR010652 Protein of unknown function DUF1232 TK78_RS28300 01c7d861c2f2ae2e57d458a89fc26829 156 Pfam PF03780 Asp23 family, cell envelope-related function 30 140 2.3E-32 T 09-03-2017 IPR005531 Alkaline shock protein Asp23 TK78_RS21855 3c0aea797a2929328ba9e6693d4e3cb2 190 SUPERFAMILY SSF53597 4 188 1.44E-23 T 09-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 TK78_RS21855 3c0aea797a2929328ba9e6693d4e3cb2 190 Gene3D G3DSA:3.40.430.10 4 188 1.4E-22 T 09-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 TK78_RS21855 3c0aea797a2929328ba9e6693d4e3cb2 190 Pfam PF01872 RibD C-terminal domain 2 182 3.6E-33 T 09-03-2017 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 TK78_RS08580 c6a21fc18edfdab7e33206bb32033ee6 39 Pfam PF04149 Domain of unknown function (DUF397) 4 34 1.1E-10 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS19430 23d439733e2b67646fd800e223cb97a6 144 Pfam PF00472 RF-1 domain 13 138 2.5E-22 T 09-03-2017 IPR000352 Peptide chain release factor class I/class II GO:0003747|GO:0006415 TK78_RS19430 23d439733e2b67646fd800e223cb97a6 144 Gene3D G3DSA:3.30.160.200 13 110 2.6E-27 T 09-03-2017 TK78_RS19430 23d439733e2b67646fd800e223cb97a6 144 SUPERFAMILY SSF75620 13 106 2.12E-12 T 09-03-2017 TK78_RS18930 dbd266ff3101c82c5e9b91e0ae81b1f8 53 SUPERFAMILY SSF51430 2 51 1.24E-10 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS18930 dbd266ff3101c82c5e9b91e0ae81b1f8 53 Pfam PF00248 Aldo/keto reductase family 2 49 4.7E-8 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS18930 dbd266ff3101c82c5e9b91e0ae81b1f8 53 Gene3D G3DSA:3.20.20.100 2 51 1.8E-10 T 09-03-2017 IPR023210 NADP-dependent oxidoreductase domain TK78_RS01415 f98ce65b28d07b881f3443245ad4d27b 401 Pfam PF06081 Aromatic acid exporter family member 1 20 156 1.5E-12 T 09-03-2017 IPR010343 Aromatic acid exporter family member 1 TK78_RS27000 da7602597c5d88cc46f1ac07215c6710 504 SUPERFAMILY SSF51905 457 495 1.1E-41 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS27000 da7602597c5d88cc46f1ac07215c6710 504 SUPERFAMILY SSF51905 2 327 1.1E-41 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS27000 da7602597c5d88cc46f1ac07215c6710 504 Gene3D G3DSA:3.50.50.60 2 78 5.2E-30 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS27000 da7602597c5d88cc46f1ac07215c6710 504 Gene3D G3DSA:3.50.50.60 400 401 5.2E-30 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS27000 da7602597c5d88cc46f1ac07215c6710 504 Gene3D G3DSA:3.50.50.60 465 495 5.2E-30 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS27000 da7602597c5d88cc46f1ac07215c6710 504 Gene3D G3DSA:3.50.50.60 123 132 5.2E-30 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS27000 da7602597c5d88cc46f1ac07215c6710 504 Gene3D G3DSA:3.50.50.60 215 293 5.2E-30 T 09-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TK78_RS27000 da7602597c5d88cc46f1ac07215c6710 504 Pfam PF01593 Flavin containing amine oxidoreductase 14 287 1.6E-15 T 09-03-2017 IPR002937 Amine oxidase GO:0016491|GO:0055114 TK78_RS26150 55a4ad14c7961ce0954abf32577ca32d 489 Pfam PF04213 Htaa 244 393 4.9E-45 T 09-03-2017 IPR007331 Htaa TK78_RS26150 55a4ad14c7961ce0954abf32577ca32d 489 Pfam PF04213 Htaa 37 203 1.7E-49 T 09-03-2017 IPR007331 Htaa TK78_RS12555 2f66e8d25a649abfbea868a7f5f0b3ad 497 Pfam PF04434 SWIM zinc finger 81 99 3.2E-5 T 09-03-2017 IPR007527 Zinc finger, SWIM-type GO:0008270 TK78_RS17850 ee8a029bd4d8dd5bb9865c6f25dee1ad 513 SMART SM00327 320 492 2.5E-5 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS17850 ee8a029bd4d8dd5bb9865c6f25dee1ad 513 Pfam PF10138 vWA found in TerF C terminus 320 508 2.1E-45 T 09-03-2017 IPR019303 vWA found in TerF C terminus TK78_RS17850 ee8a029bd4d8dd5bb9865c6f25dee1ad 513 SUPERFAMILY SSF53300 321 478 3.71E-11 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS08250 99b7803f853504dd6ed2f7911d5ade7c 317 SUPERFAMILY SSF55797 194 316 1.09E-25 T 09-03-2017 IPR014044 CAP domain TK78_RS08250 99b7803f853504dd6ed2f7911d5ade7c 317 Gene3D G3DSA:3.40.33.10 192 315 5.2E-13 T 09-03-2017 IPR014044 CAP domain TK78_RS08250 99b7803f853504dd6ed2f7911d5ade7c 317 Pfam PF00188 Cysteine-rich secretory protein family 201 315 7.6E-23 T 09-03-2017 IPR014044 CAP domain TK78_RS23305 9129ba0ecd838b4b2548b38a9b393066 220 Gene3D G3DSA:3.40.50.150 7 220 6.3E-82 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS23305 9129ba0ecd838b4b2548b38a9b393066 220 SUPERFAMILY SSF53335 15 220 5.57E-51 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS23305 9129ba0ecd838b4b2548b38a9b393066 220 Pfam PF01596 O-methyltransferase 20 219 1.7E-70 T 09-03-2017 IPR002935 O-methyltransferase, family 3 GO:0008171 TK78_RS28360 d7899e6697babee9fa6365ec54f6957f 232 Pfam PF07947 YhhN-like protein 47 220 7.5E-38 T 09-03-2017 IPR012506 YhhN-like GO:0016021 TK78_RS10575 2fd5862a3da9978bc900b1cd40e1dbb5 122 Hamap MF_01479 Transcriptional regulator WhiB [whiB]. 27 111 14.548 T 09-03-2017 IPR003482 Transcription factor WhiB TK78_RS10575 2fd5862a3da9978bc900b1cd40e1dbb5 122 ProSitePatterns PS00354 HMG-I and HMG-Y DNA-binding domain (A+T-hook). 107 117 - T 09-03-2017 IPR000637 HMG-I/HMG-Y, DNA-binding, conserved site GO:0006355 TK78_RS10575 2fd5862a3da9978bc900b1cd40e1dbb5 122 Pfam PF02467 Transcription factor WhiB 49 97 1.6E-14 T 09-03-2017 IPR003482 Transcription factor WhiB TK78_RS14440 18929c5f283266b389d7913a836ee654 79 Pfam PF04149 Domain of unknown function (DUF397) 6 24 2.4E-8 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS14440 18929c5f283266b389d7913a836ee654 79 Pfam PF04149 Domain of unknown function (DUF397) 26 76 2.5E-20 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS00345 9527e37b4bfcf5bb9f92d8e128d10250 101 Pfam PF13586 Transposase DDE domain 1 97 1.2E-24 T 09-03-2017 IPR025668 Transposase DDE domain TK78_RS03225 ef71b421cb909d6d1e2081b77394f38c 258 Gene3D G3DSA:3.90.226.10 7 247 1.0E-65 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS03225 ef71b421cb909d6d1e2081b77394f38c 258 Pfam PF00378 Enoyl-CoA hydratase/isomerase 13 251 5.4E-42 T 09-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 TK78_RS03225 ef71b421cb909d6d1e2081b77394f38c 258 SUPERFAMILY SSF52096 6 251 3.95E-68 T 09-03-2017 IPR029045 ClpP/crotonase-like domain TK78_RS28010 51f56d168eddcbd293a917c1b9568b05 112 SUPERFAMILY SSF117916 9 106 1.93E-27 T 09-03-2017 TK78_RS28010 51f56d168eddcbd293a917c1b9568b05 112 Pfam PF01883 Domain of unknown function DUF59 14 74 1.2E-18 T 09-03-2017 IPR002744 Domain of unknown function DUF59 TK78_RS28960 625327ddc941f0827475c71058e46b1c 398 Gene3D G3DSA:3.30.1540.10 223 307 2.6E-29 T 09-03-2017 TK78_RS28960 625327ddc941f0827475c71058e46b1c 398 Pfam PF02515 CoA-transferase family III 8 374 6.2E-110 T 09-03-2017 IPR003673 CoA-transferase family III GO:0003824 TK78_RS28960 625327ddc941f0827475c71058e46b1c 398 SUPERFAMILY SSF89796 3 397 3.92E-123 T 09-03-2017 IPR023606 CoA-transferase family III domain TK78_RS28960 625327ddc941f0827475c71058e46b1c 398 Gene3D G3DSA:3.40.50.10540 308 397 3.9E-97 T 09-03-2017 IPR023606 CoA-transferase family III domain TK78_RS28960 625327ddc941f0827475c71058e46b1c 398 Gene3D G3DSA:3.40.50.10540 6 217 3.9E-97 T 09-03-2017 IPR023606 CoA-transferase family III domain TK78_RS17180 d33ce097f01bd4f8b39c079c82167fe9 458 Pfam PF00144 Beta-lactamase 25 327 1.0E-60 T 09-03-2017 IPR001466 Beta-lactamase-related TK78_RS17180 d33ce097f01bd4f8b39c079c82167fe9 458 SUPERFAMILY SSF56601 19 322 2.91E-74 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS17180 d33ce097f01bd4f8b39c079c82167fe9 458 Gene3D G3DSA:3.40.710.10 26 338 3.1E-75 T 09-03-2017 IPR012338 Beta-lactamase/transpeptidase-like TK78_RS11805 537e7267a92a9d6b9926884f91376deb 418 Gene3D G3DSA:1.20.1250.20 219 396 3.9E-7 T 09-03-2017 TK78_RS11805 537e7267a92a9d6b9926884f91376deb 418 Gene3D G3DSA:1.20.1250.20 33 203 1.1E-7 T 09-03-2017 TK78_RS11805 537e7267a92a9d6b9926884f91376deb 418 SUPERFAMILY SSF103473 24 395 1.7E-23 T 09-03-2017 IPR020846 Major facilitator superfamily domain TK78_RS16385 5fe9814be8c31baeca1c62d0d559ad86 408 Pfam PF00999 Sodium/hydrogen exchanger family 8 387 1.8E-50 T 09-03-2017 IPR006153 Cation/H+ exchanger GO:0006812|GO:0015299|GO:0016021|GO:0055085 TK78_RS00885 c80551241eeffbfaea23aede2214b3e3 64 Pfam PF14013 MT0933-like antitoxin protein 4 52 1.0E-18 T 09-03-2017 IPR028037 Antitoxin Rv0909/MT0933 TK78_RS25805 5063504542edbbe5c01f486d46333386 422 Pfam PF00432 Prenyltransferase and squalene oxidase repeat 133 168 6.5E-8 T 09-03-2017 IPR001330 PFTB repeat GO:0003824 TK78_RS25805 5063504542edbbe5c01f486d46333386 422 Gene3D G3DSA:1.50.10.20 75 229 2.2E-17 T 09-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid TK78_RS25805 5063504542edbbe5c01f486d46333386 422 SUPERFAMILY SSF48239 47 195 9.73E-22 T 09-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid TK78_RS19315 350f763a343c363581292f028c0a46ab 263 PIRSF PIRSF006648 2 262 4.1E-65 T 09-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 TK78_RS19315 350f763a343c363581292f028c0a46ab 263 PRINTS PR00164 ABC-2 type transport system membrane protein signature 29 50 7.6E-5 T 09-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 TK78_RS19315 350f763a343c363581292f028c0a46ab 263 PRINTS PR00164 ABC-2 type transport system membrane protein signature 205 224 7.6E-5 T 09-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 TK78_RS19315 350f763a343c363581292f028c0a46ab 263 PRINTS PR00164 ABC-2 type transport system membrane protein signature 108 133 7.6E-5 T 09-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 TK78_RS19315 350f763a343c363581292f028c0a46ab 263 PRINTS PR00164 ABC-2 type transport system membrane protein signature 185 204 7.6E-5 T 09-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 TK78_RS19315 350f763a343c363581292f028c0a46ab 263 Pfam PF01061 ABC-2 type transporter 12 227 2.1E-28 T 09-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 TK78_RS04085 73c303455f5a04328be6a62f139cb7b1 383 Gene3D G3DSA:3.40.640.10 21 247 1.0E-18 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS04085 73c303455f5a04328be6a62f139cb7b1 383 SUPERFAMILY SSF53383 8 341 8.17E-32 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS04085 73c303455f5a04328be6a62f139cb7b1 383 Pfam PF00155 Aminotransferase class I and II 53 319 3.7E-7 T 09-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TK78_RS08515 089efa613c044c8ed111c31885634d2b 361 Pfam PF01032 FecCD transport family 48 353 8.1E-79 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS08515 089efa613c044c8ed111c31885634d2b 361 SUPERFAMILY SSF81345 34 353 8.11E-68 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS08515 089efa613c044c8ed111c31885634d2b 361 Gene3D G3DSA:1.10.3470.10 35 356 3.2E-87 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS09580 2752ffe1c9d486fb9b3f209150dbdaa5 283 Pfam PF12679 ABC-2 family transporter protein 91 283 9.3E-10 T 09-03-2017 IPR032688 ABC-2 family transporter protein GO:0006810 TK78_RS06550 60a633335af2140012e0991d26a24494 215 Pfam PF01810 LysE type translocator 17 207 5.0E-23 T 09-03-2017 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 TK78_RS06550 60a633335af2140012e0991d26a24494 215 PIRSF PIRSF006324 1 209 1.2E-41 T 09-03-2017 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 TK78_RS24720 217fc107269a54b1fa84c5341aeb4d43 394 Pfam PF13556 PucR C-terminal helix-turn-helix domain 331 389 7.3E-19 T 09-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain TK78_RS00545 9e7166756482b19d5e49e999e8aff4ca 65 SUPERFAMILY SSF54862 3 63 2.88E-13 T 09-03-2017 TK78_RS00545 9e7166756482b19d5e49e999e8aff4ca 65 Gene3D G3DSA:3.30.70.20 3 64 2.1E-17 T 09-03-2017 TK78_RS00545 9e7166756482b19d5e49e999e8aff4ca 65 Pfam PF13459 4Fe-4S single cluster domain 3 60 3.1E-14 T 09-03-2017 TK78_RS00545 9e7166756482b19d5e49e999e8aff4ca 65 PRINTS PR00352 3Fe-4S ferredoxin signature 48 60 1.0E-8 T 09-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 TK78_RS00545 9e7166756482b19d5e49e999e8aff4ca 65 PRINTS PR00352 3Fe-4S ferredoxin signature 5 16 1.0E-8 T 09-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 TK78_RS00545 9e7166756482b19d5e49e999e8aff4ca 65 PRINTS PR00352 3Fe-4S ferredoxin signature 16 26 1.0E-8 T 09-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 TK78_RS34210 be15707beb4c03720e77b9f556edad29 242 Pfam PF04892 VanZ like family 16 133 3.7E-22 T 09-03-2017 IPR006976 VanZ-like TK78_RS07515 3dfe64f860f38dc37574fd3a76d23291 64 Pfam PF11248 Protein of unknown function (DUF3046) 1 61 5.2E-32 T 09-03-2017 IPR021408 Protein of unknown function DUF3046 TK78_RS03055 17c8f7407b8dee3de9359a69c5fd5ac6 146 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 10 93 1.2E-10 T 09-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 TK78_RS03055 17c8f7407b8dee3de9359a69c5fd5ac6 146 SUPERFAMILY SSF50475 9 142 5.64E-32 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS03055 17c8f7407b8dee3de9359a69c5fd5ac6 146 TIGRFAM TIGR03618 Rv1155_F420: PPOX class probable F420-dependent enzyme 12 142 3.0E-38 T 09-03-2017 IPR019920 F420-binding domain, putative TK78_RS03055 17c8f7407b8dee3de9359a69c5fd5ac6 146 Gene3D G3DSA:2.30.110.10 8 142 6.1E-24 T 09-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 TK78_RS08885 ef2d7fd558c4cd228121bd574876e75c 111 Pfam PF04248 Domain of unknown function (DUF427) 18 105 1.2E-32 T 09-03-2017 IPR007361 Domain of unknown function DUF427 TK78_RS08375 13b2e31eca89cf2b988125e130b71211 72 Pfam PF13826 Domain of unknown function (DUF4188) 2 46 9.1E-12 T 09-03-2017 IPR025444 Protein of unknown function DUF4188 TK78_RS21420 e17aa8171b94f23e5732c7c8f2c771e5 119 Pfam PF05331 Protein of unknown function (DUF742) 9 119 2.3E-38 T 09-03-2017 IPR007995 Protein of unknown function DUF742 TK78_RS07020 1fb303bf76aa3d5520830d862c901f92 454 Pfam PF03559 NDP-hexose 2,3-dehydratase 243 446 3.2E-73 T 09-03-2017 IPR005212 NDP-hexose 2,3-dehydratase TK78_RS07020 1fb303bf76aa3d5520830d862c901f92 454 Pfam PF03559 NDP-hexose 2,3-dehydratase 27 229 7.0E-85 T 09-03-2017 IPR005212 NDP-hexose 2,3-dehydratase TK78_RS32010 ff1a7195c9975205205c2d1706ce70fb 277 Gene3D G3DSA:3.40.50.10320 6 276 6.5E-78 T 09-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 TK78_RS32010 ff1a7195c9975205205c2d1706ce70fb 277 Pfam PF02585 GlcNAc-PI de-N-acetylase 9 156 2.0E-27 T 09-03-2017 IPR003737 N-acetylglucosaminyl phosphatidylinositol deacetylase-related Reactome: R-HSA-162710 TK78_RS32010 ff1a7195c9975205205c2d1706ce70fb 277 SUPERFAMILY SSF102588 5 276 3.14E-63 T 09-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 TK78_RS11350 ce6690dffa5ac852e35e292730379411 329 TIGRFAM TIGR00216 ispH_lytB: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 12 290 3.9E-95 T 09-03-2017 IPR003451 4-hydroxy-3-methylbut-2-enyl diphosphate reductase GO:0019288|GO:0046872|GO:0050992|GO:0051745 TK78_RS11350 ce6690dffa5ac852e35e292730379411 329 Hamap MF_00191 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [ispH]. 10 293 36.535 T 09-03-2017 IPR003451 4-hydroxy-3-methylbut-2-enyl diphosphate reductase GO:0019288|GO:0046872|GO:0050992|GO:0051745 TK78_RS11350 ce6690dffa5ac852e35e292730379411 329 Pfam PF02401 LytB protein 12 289 2.4E-87 T 09-03-2017 IPR003451 4-hydroxy-3-methylbut-2-enyl diphosphate reductase GO:0019288|GO:0046872|GO:0050992|GO:0051745 TK78_RS31380 3e4d02c57b3772ab63a21ef737338921 76 Gene3D G3DSA:1.10.1200.20 5 74 4.0E-8 T 09-03-2017 IPR023802 Colicin/pyocin immunity protein domain GO:0015643 TK78_RS16945 550f5342479a7e3cb7fbff4b57236d69 250 SMART SM00943 25 209 6.5E-23 T 09-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal TK78_RS16945 550f5342479a7e3cb7fbff4b57236d69 250 Pfam PF09250 Bifunctional DNA primase/polymerase, N-terminal 26 198 1.2E-19 T 09-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal TK78_RS05995 822a0bc24237366b076b09e6dff4b16a 435 Pfam PF02653 Branched-chain amino acid transport system / permease component 89 418 2.1E-32 T 09-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 TK78_RS18580 7692027e41b36bf36874699bccc78a76 604 Pfam PF06259 Alpha/beta hydrolase 332 505 6.1E-32 T 09-03-2017 IPR010427 Protein of unknown function DUF1023 TK78_RS01650 104c4073002bd11bc9da6e96b8a81a21 93 Pfam PF03777 Small secreted domain (DUF320) 23 78 1.1E-28 T 09-03-2017 IPR005528 Domain of unknown function DUF320, Streptomyces species TK78_RS10020 e8cc570b1c12597293b78777eb3c59fb 285 Pfam PF13349 Putative adhesin 139 265 6.0E-8 T 09-03-2017 IPR025164 Putative adhesin TK78_RS11425 b85665da083e40e0c38ba953d7f35647 244 Pfam PF00975 Thioesterase domain 8 234 7.9E-33 T 09-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 TK78_RS11425 b85665da083e40e0c38ba953d7f35647 244 Gene3D G3DSA:3.40.50.1820 171 237 7.5E-27 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS11425 b85665da083e40e0c38ba953d7f35647 244 Gene3D G3DSA:3.40.50.1820 5 119 7.5E-27 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS11425 b85665da083e40e0c38ba953d7f35647 244 SUPERFAMILY SSF53474 4 235 8.84E-41 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS02845 b572edc03392d7cc799ac736888e5360 255 Pfam PF02754 Cysteine-rich domain 136 220 9.7E-14 T 09-03-2017 IPR004017 Cysteine-rich domain TK78_RS02845 b572edc03392d7cc799ac736888e5360 255 Pfam PF02754 Cysteine-rich domain 4 85 4.7E-11 T 09-03-2017 IPR004017 Cysteine-rich domain TK78_RS34425 994aaee68ece003da5d9d44eb371a625 702 Pfam PF13515 Fusaric acid resistance protein-like 382 504 1.8E-6 T 09-03-2017 TK78_RS17105 e130e955f49924dd9b70465ce6244387 118 Gene3D G3DSA:1.20.1080.10 26 96 8.7E-4 T 09-03-2017 IPR023271 Aquaporin-like Reactome: R-HSA-432047 TK78_RS17105 e130e955f49924dd9b70465ce6244387 118 Pfam PF05656 Protein of unknown function (DUF805) 11 111 3.4E-32 T 09-03-2017 IPR008523 Protein of unknown function DUF805 GO:0016021 TK78_RS20165 5dc16258236a2b51dbc81718a496c88a 263 Gene3D G3DSA:1.10.3720.10 7 257 7.5E-35 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS20165 5dc16258236a2b51dbc81718a496c88a 263 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 84 254 5.9E-13 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS20165 5dc16258236a2b51dbc81718a496c88a 263 SUPERFAMILY SSF161098 11 253 1.09E-33 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS21990 f422355c16f16716cc673edb3cc24410 126 Pfam PF12005 Protein of unknown function (DUF3499) 5 122 6.8E-48 T 09-03-2017 IPR021888 Protein of unknown function DUF3499 TK78_RS30630 63128fcbd49ab0bb312cdc6f38812a25 1211 Pfam PF02538 Hydantoinase B/oxoprolinase 704 1208 9.1E-201 T 09-03-2017 IPR003692 Hydantoinase B/oxoprolinase GO:0003824 Reactome: R-HSA-174403|Reactome: R-HSA-5578998 TK78_RS30630 63128fcbd49ab0bb312cdc6f38812a25 1211 Pfam PF05378 Hydantoinase/oxoprolinase N-terminal region 7 185 9.9E-57 T 09-03-2017 IPR008040 Hydantoinaseoxoprolinase, N-terminal Reactome: R-HSA-174403|Reactome: R-HSA-5578998 TK78_RS30630 63128fcbd49ab0bb312cdc6f38812a25 1211 Pfam PF01968 Hydantoinase/oxoprolinase 205 492 3.3E-109 T 09-03-2017 IPR002821 Hydantoinase/oxoprolinase GO:0016787 Reactome: R-HSA-174403|Reactome: R-HSA-5578998 TK78_RS05790 547ca478a57d582d90375a619b48b531 81 Pfam PF04149 Domain of unknown function (DUF397) 27 77 1.3E-20 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS05790 547ca478a57d582d90375a619b48b531 81 Pfam PF04149 Domain of unknown function (DUF397) 7 25 1.0E-6 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS32185 c516fce3b94846e0d4fe28d4db37f7dc 117 Gene3D G3DSA:2.30.30.240 18 84 4.6E-5 T 09-03-2017 TK78_RS32185 c516fce3b94846e0d4fe28d4db37f7dc 117 SUPERFAMILY SSF50346 14 114 1.04E-22 T 09-03-2017 IPR011033 PRC-barrel-like TK78_RS17610 9f51979d8b630ebf4af728d594089889 475 SMART SM00752 60 405 2.8E-90 T 09-03-2017 IPR011020 HTTM Reactome: R-HSA-159740 TK78_RS34605 2430b4b18beb4fc88d600c11dc5df349 431 SUPERFAMILY SSF52129 36 228 2.72E-5 T 09-03-2017 IPR029030 Caspase-like domain TK78_RS34605 2430b4b18beb4fc88d600c11dc5df349 431 Gene3D G3DSA:3.40.50.1460 14 155 3.8E-5 T 09-03-2017 IPR029030 Caspase-like domain TK78_RS34605 2430b4b18beb4fc88d600c11dc5df349 431 Pfam PF00656 Caspase domain 15 156 1.2E-7 T 09-03-2017 TK78_RS05300 3639a212399fbeea47fc8e9761df0f5e 364 Pfam PF10935 Protein of unknown function (DUF2637) 66 214 4.1E-23 T 09-03-2017 IPR021235 Protein of unknown function DUF2637 TK78_RS13725 03dd7d275e2f59787957357e47ed6e6c 295 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 119 291 3.2E-25 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS13725 03dd7d275e2f59787957357e47ed6e6c 295 Gene3D G3DSA:1.10.3720.10 97 290 4.1E-25 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS13725 03dd7d275e2f59787957357e47ed6e6c 295 SUPERFAMILY SSF161098 96 278 1.44E-32 T 09-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 TK78_RS32665 bae8bdf74998b9ff6c3b0705e4733a97 202 Pfam PF17197 Domain of unknown function (DUF5134) 33 202 6.9E-37 T 09-03-2017 IPR033458 Protein of unknown function DUF5134 TK78_RS03580 1b6813c77c6a59ffdf27453c7a3923f5 78 Pfam PF04149 Domain of unknown function (DUF397) 18 69 1.2E-13 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS19915 f57065eeadce78af8aae91f5e20def9f 240 PIRSF PIRSF006648 1 240 2.9E-19 T 09-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 TK78_RS19915 f57065eeadce78af8aae91f5e20def9f 240 Pfam PF01061 ABC-2 type transporter 7 202 1.9E-32 T 09-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 TK78_RS17945 e95a2cc85e5dd6343856e71f9305fa10 357 Pfam PF13556 PucR C-terminal helix-turn-helix domain 288 344 5.2E-16 T 09-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain TK78_RS12070 fe4caeaaffa2b4fa347cf263836a1fdd 235 SUPERFAMILY SSF52540 31 187 9.32E-10 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS12070 fe4caeaaffa2b4fa347cf263836a1fdd 235 PRINTS PR00988 Uridine kinase signature 161 171 3.9E-7 T 09-03-2017 IPR000764 Uridine kinase-like KEGG: 00240+2.7.1.48|KEGG: 00983+2.7.1.48|MetaCyc: PWY-7193 TK78_RS12070 fe4caeaaffa2b4fa347cf263836a1fdd 235 PRINTS PR00988 Uridine kinase signature 30 47 3.9E-7 T 09-03-2017 IPR000764 Uridine kinase-like KEGG: 00240+2.7.1.48|KEGG: 00983+2.7.1.48|MetaCyc: PWY-7193 TK78_RS12070 fe4caeaaffa2b4fa347cf263836a1fdd 235 PRINTS PR00988 Uridine kinase signature 101 116 3.9E-7 T 09-03-2017 IPR000764 Uridine kinase-like KEGG: 00240+2.7.1.48|KEGG: 00983+2.7.1.48|MetaCyc: PWY-7193 TK78_RS12070 fe4caeaaffa2b4fa347cf263836a1fdd 235 Gene3D G3DSA:3.40.50.300 31 197 1.7E-21 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS01350 a16835161f8b2b26d888ccc2da64a4d1 175 Pfam PF04140 Isoprenylcysteine carboxyl methyltransferase (ICMT) family 76 166 3.7E-27 T 09-03-2017 IPR007269 Isoprenylcysteine carboxyl methyltransferase GO:0004671|GO:0006481|GO:0016021 Reactome: R-HSA-163841 TK78_RS00800 497e196d48e7de25f2d8b262fb36b46c 324 Pfam PF07070 SpoOM protein 3 217 1.4E-71 T 09-03-2017 IPR009776 Sporulation stage 0, protein M TK78_RS28320 ca8f7b4d2b331f44330258650baace78 192 Gene3D G3DSA:1.20.58.340 4 80 2.5E-4 T 09-03-2017 TK78_RS08555 939e6256b1be9435f1c42b5c05e84fab 88 Pfam PF04226 Transglycosylase associated protein 33 83 5.3E-10 T 09-03-2017 IPR007341 Transglycosylase-associated protein GO:0016021 TK78_RS05000 296479a5495e3891f0d164f85dfd1b83 132 Pfam PF13309 HTH domain 63 124 1.6E-19 T 09-03-2017 TK78_RS13360 35fb8073ac5598e5f5bd5e53c8c4eede 90 Pfam PF04226 Transglycosylase associated protein 33 83 4.9E-8 T 09-03-2017 IPR007341 Transglycosylase-associated protein GO:0016021 TK78_RS12535 5cd45c9b480fa969e351498b705fdb2c 437 Pfam PF05762 VWA domain containing CoxE-like protein 181 418 5.4E-59 T 09-03-2017 IPR008912 Uncharacterised protein family CoxE-like TK78_RS12535 5cd45c9b480fa969e351498b705fdb2c 437 Gene3D G3DSA:3.40.50.410 260 380 1.6E-4 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS12535 5cd45c9b480fa969e351498b705fdb2c 437 SMART SM00327 261 420 7.4E-4 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS12535 5cd45c9b480fa969e351498b705fdb2c 437 SUPERFAMILY SSF53300 260 423 4.6E-25 T 09-03-2017 IPR002035 von Willebrand factor, type A TK78_RS15805 f97a865bbf46de986eeeb8470416ab47 175 SUPERFAMILY SSF160904 2 159 1.12E-30 T 09-03-2017 TK78_RS15805 f97a865bbf46de986eeeb8470416ab47 175 Gene3D G3DSA:1.10.3300.10 2 161 3.1E-29 T 09-03-2017 IPR023286 ABATE domain TK78_RS15805 f97a865bbf46de986eeeb8470416ab47 175 Pfam PF11706 CGNR zinc finger 117 160 4.1E-17 T 09-03-2017 IPR021005 Zinc finger, CGNR TK78_RS00875 8da099aefb95b3c8f55bd2b64a1442a8 277 SUPERFAMILY SSF81606 76 268 6.41E-6 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS00875 8da099aefb95b3c8f55bd2b64a1442a8 277 SMART SM00331 55 269 4.5E-29 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS00875 8da099aefb95b3c8f55bd2b64a1442a8 277 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 85 269 5.6E-41 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS32540 00b2d9584eb2df779c52feb420f531c5 83 Pfam PF02416 mttA/Hcf106 family 2 49 2.2E-8 T 09-03-2017 IPR003369 Sec-independent protein translocase protein TatA/B/E GO:0008565|GO:0015031 TK78_RS08440 4bf2650c54d4dc9a8646252c83c2b16b 135 Pfam PF05331 Protein of unknown function (DUF742) 24 135 1.7E-40 T 09-03-2017 IPR007995 Protein of unknown function DUF742 TK78_RS28860 bdd0cbffdedcd257a60bf2e33fb0d5ee 54 TIGRFAM TIGR04268 FxSxx-COOH: FXSXX-COOH protein 12 54 4.7E-9 T 09-03-2017 IPR026334 FXSXX-COOH protein TK78_RS20255 2623e5f2810acf45ca782d294ccb4058 124 Pfam PF13396 Phospholipase_D-nuclease N-terminal 11 55 4.3E-13 T 09-03-2017 IPR027379 Cardiolipin synthase N-terminal TK78_RS24735 f2d3ded086454df40203afa44d899175 266 Gene3D G3DSA:3.40.50.1110 14 263 2.7E-61 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS24735 f2d3ded086454df40203afa44d899175 266 SUPERFAMILY SSF52266 15 263 2.0E-56 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS24735 f2d3ded086454df40203afa44d899175 266 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 18 254 5.0E-25 T 09-03-2017 IPR013830 SGNH hydrolase-type esterase domain TK78_RS08960 dfc5f0260a95614189a3eba5ef6146b1 262 Pfam PF14581 SseB protein C-terminal domain 135 239 1.5E-19 T 09-03-2017 IPR027945 SseB protein, C-terminal TK78_RS04895 b54574849dfadbdd967e0d1b4f5d7afa 359 Pfam PF02687 FtsX-like permease family 243 351 3.1E-10 T 09-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 TK78_RS20340 bda6ffc5d00ea8ab1fb5e818075936f9 398 SMART SM00331 174 387 3.6E-13 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS20340 bda6ffc5d00ea8ab1fb5e818075936f9 398 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 199 387 5.1E-33 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS20340 bda6ffc5d00ea8ab1fb5e818075936f9 398 SUPERFAMILY SSF81606 189 335 1.2E-12 T 09-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 TK78_RS25875 a5adf89dc76630b06fecc31acd0fad66 83 Gene3D G3DSA:1.10.1200.10 3 67 5.1E-8 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS25875 a5adf89dc76630b06fecc31acd0fad66 83 SUPERFAMILY SSF47336 17 69 3.52E-7 T 09-03-2017 IPR009081 Phosphopantetheine binding ACP domain TK78_RS25500 5cc0cb7d28cd23dcca412efa3d91a2e9 477 Pfam PF00939 Sodium:sulfate symporter transmembrane region 14 468 5.4E-30 T 09-03-2017 IPR001898 Sodium/sulphate symporter GO:0005215|GO:0006814|GO:0016020|GO:0055085 Reactome: R-HSA-433137 TK78_RS00555 336b6afb811b04f9112c004c3f4a9160 163 Pfam PF16571 FBP C-terminal treble-clef zinc-finger 8 161 2.5E-62 T 09-03-2017 IPR032330 Elongation factor G-binding protein, C-terminal treble-clef zinc-finger TK78_RS04430 2ef3366588dd108743db8913e959523d 688 Pfam PF13520 Amino acid permease 119 492 2.3E-27 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS20240 a17bf23183c20f6d83315df4a8be5d1c 260 Pfam PF02683 Cytochrome C biogenesis protein transmembrane region 32 239 5.2E-53 T 09-03-2017 IPR003834 Cytochrome C biogenesis protein, transmembrane domain GO:0016020|GO:0017004|GO:0055114 TK78_RS32815 0f07390b454a01a7a08190b62ca25e10 193 Pfam PF16157 Domain of unknown function (DUF4865) 2 180 1.7E-71 T 09-03-2017 IPR032349 Protein of unknown function DUF4865 TK78_RS21155 6929738e1fe889c67ee52ff82c49b43c 589 Pfam PF02366 Dolichyl-phosphate-mannose-protein mannosyltransferase 82 308 7.8E-23 T 09-03-2017 IPR003342 Glycosyl transferase family 39/83 GO:0000030|GO:0006493|GO:0016020 Reactome: R-HSA-5173105 TK78_RS21155 6929738e1fe889c67ee52ff82c49b43c 589 Pfam PF16192 C-terminal four TMM region of protein-O-mannosyltransferase 383 588 2.0E-22 T 09-03-2017 IPR032421 Protein O-mannosyl-transferase, C-terminal four TM domain KEGG: 00500+2.4.1.10|KEGG: 00514+2.4.1.109|MetaCyc: PWY-822|Reactome: R-HSA-5173105 TK78_RS19505 91d110d9bf3b5c8b10fefb5c6ab0267e 396 Pfam PF10979 Protein of unknown function (DUF2786) 155 194 2.4E-16 T 09-03-2017 IPR024498 Domain of unknown function DUF2786 TK78_RS19505 91d110d9bf3b5c8b10fefb5c6ab0267e 396 ProDom PD120223 SCO3432 GENE ML2604 GP79 GP77 CGL2230 MB0190 157 370 6.0E-77 T 09-03-2017 TK78_RS20425 ae15a1b6c336f3b440b711850707f0a2 178 SUPERFAMILY SSF55154 5 156 3.71E-13 T 09-03-2017 IPR033469 CYTH-like domain Reactome: R-HSA-196819 TK78_RS20425 ae15a1b6c336f3b440b711850707f0a2 178 Gene3D G3DSA:2.40.320.10 4 153 2.3E-19 T 09-03-2017 IPR023577 CYTH domain Reactome: R-HSA-196819 TK78_RS26465 f5fc650e19abf7d533c1533e6d14da0f 63 SUPERFAMILY SSF46689 4 54 3.36E-5 T 09-03-2017 IPR009057 Homeodomain-like GO:0003677 TK78_RS14970 ed602b5547615af9aa8d50a8e307ad97 165 Pfam PF13471 Transglutaminase-like superfamily 21 132 8.6E-23 T 09-03-2017 IPR032708 Microcin J25-processing protein McjB, C-terminal TK78_RS33040 71ac2281b5fb0b58d382eb85a48d5575 136 Pfam PF13581 Histidine kinase-like ATPase domain 2 118 1.8E-12 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS33040 71ac2281b5fb0b58d382eb85a48d5575 136 Gene3D G3DSA:3.30.565.10 32 69 6.4E-5 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS33040 71ac2281b5fb0b58d382eb85a48d5575 136 SUPERFAMILY SSF55874 25 126 1.93E-7 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS05610 69a676cfb1f39c95762721d491806dab 117 Pfam PF14230 Domain of unknown function (DUF4333) 20 99 1.4E-18 T 09-03-2017 IPR025637 Domain of unknown function DUF4333 TK78_RS23985 1a44c95e414ea4bf50c3d457fb93131e 303 Pfam PF12679 ABC-2 family transporter protein 38 301 7.6E-11 T 09-03-2017 IPR032688 ABC-2 family transporter protein GO:0006810 TK78_RS18370 723399eb963b39ed314b7463564ade29 738 SMART SM00487 77 277 4.2E-49 T 09-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain TK78_RS18370 723399eb963b39ed314b7463564ade29 738 Gene3D G3DSA:3.40.50.300 47 266 8.4E-70 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18370 723399eb963b39ed314b7463564ade29 738 Gene3D G3DSA:3.40.50.300 267 416 1.1E-41 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18370 723399eb963b39ed314b7463564ade29 738 Pfam PF00271 Helicase conserved C-terminal domain 294 392 7.6E-23 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS18370 723399eb963b39ed314b7463564ade29 738 SUPERFAMILY SSF52540 129 413 3.12E-64 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS18370 723399eb963b39ed314b7463564ade29 738 SMART SM00490 311 392 1.3E-28 T 09-03-2017 IPR001650 Helicase, C-terminal TK78_RS18370 723399eb963b39ed314b7463564ade29 738 Pfam PF00270 DEAD/DEAH box helicase 82 248 7.1E-44 T 09-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 TK78_RS18590 cea870335f83af482df46a992446c083 815 Pfam PF06259 Alpha/beta hydrolase 538 713 3.9E-33 T 09-03-2017 IPR010427 Protein of unknown function DUF1023 TK78_RS18590 cea870335f83af482df46a992446c083 815 SUPERFAMILY SSF53474 604 709 9.41E-5 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS18590 cea870335f83af482df46a992446c083 815 SUPERFAMILY SSF64518 194 326 4.18E-5 T 09-03-2017 TK78_RS16100 22555324f4c8f9037215a5ec14a207ac 217 Pfam PF02397 Bacterial sugar transferase 39 185 2.0E-16 T 09-03-2017 IPR003362 Bacterial sugar transferase TK78_RS16475 455a87fab7c0a7b48a2438b8794cbdb8 83 Gene3D G3DSA:1.10.1200.20 13 81 2.7E-9 T 09-03-2017 IPR023802 Colicin/pyocin immunity protein domain GO:0015643 TK78_RS16475 455a87fab7c0a7b48a2438b8794cbdb8 83 SUPERFAMILY SSF47345 14 79 7.46E-5 T 09-03-2017 IPR023802 Colicin/pyocin immunity protein domain GO:0015643 TK78_RS01515 c689827f7ae8e037c61c391b1c9b0f11 902 Pfam PF04738 Lantibiotic dehydratase, C terminus 159 863 1.7E-29 T 09-03-2017 IPR006827 Lantibiotic dehydratase, C-terminal TK78_RS07530 efc94875a4cb4cb9e63fb29fd1f0ec73 274 Pfam PF03591 AzlC protein 44 179 7.1E-29 T 09-03-2017 IPR011606 Branched-chain amino acid transport, permease TK78_RS27725 25aa7bf3a3f994d7ca2819b3b48199cc 459 Pfam PF04434 SWIM zinc finger 166 187 1.6E-5 T 09-03-2017 IPR007527 Zinc finger, SWIM-type GO:0008270 TK78_RS26610 3c24fa1f2aa0e53452fbfc9b0a564c01 173 Pfam PF14024 Protein of unknown function (DUF4240) 1 128 3.6E-45 T 09-03-2017 IPR025334 Domain of unknown function (DUF4240 TK78_RS29950 2d9fc7c6597cafa2a0a9fd510b14d885 98 Pfam PF13453 Transcription factor zinc-finger 3 41 5.7E-17 T 09-03-2017 IPR027392 Transcription factor zinc-finger TK78_RS05435 cb816cc30e774b6af0cd7218bdff45fd 401 Pfam PF03631 Virulence factor BrkB 27 280 6.4E-45 T 09-03-2017 IPR017039 Virulence factor BrkB TK78_RS28395 4f5e948207ace89f86461f9a9ab22f84 125 Pfam PF11298 Protein of unknown function (DUF3099) 12 80 4.3E-24 T 09-03-2017 IPR021449 Protein of unknown function DUF3099 TK78_RS28355 eae646abca5ed6358993fe819ff4732c 328 Pfam PF04116 Fatty acid hydroxylase superfamily 86 219 2.6E-27 T 09-03-2017 IPR006694 Fatty acid hydroxylase GO:0005506|GO:0006633|GO:0016491|GO:0055114 TK78_RS18860 cd36437e571b283845c99a2a4650dd70 85 Pfam PF11298 Protein of unknown function (DUF3099) 3 60 6.2E-8 T 09-03-2017 IPR021449 Protein of unknown function DUF3099 TK78_RS26125 230b4d77d5b1ed0114d27c85cbdd5dd5 248 SMART SM00943 39 221 2.1E-33 T 09-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal TK78_RS26125 230b4d77d5b1ed0114d27c85cbdd5dd5 248 Pfam PF09250 Bifunctional DNA primase/polymerase, N-terminal 40 212 3.2E-24 T 09-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal TK78_RS06075 1675368e32ada37af3c6a8b143030b3d 144 Gene3D G3DSA:3.10.180.10 8 143 1.6E-6 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS06075 1675368e32ada37af3c6a8b143030b3d 144 SUPERFAMILY SSF54593 8 143 1.89E-6 T 09-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase TK78_RS28380 49b2c5642270510f5b26c44e1d9fa98a 547 TIGRFAM TIGR00813 sss: transporter, solute:sodium symporter (SSS) family 54 469 2.3E-56 T 09-03-2017 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 TK78_RS28380 49b2c5642270510f5b26c44e1d9fa98a 547 Pfam PF00474 Sodium:solute symporter family 54 470 7.5E-93 T 09-03-2017 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 TK78_RS29540 a1697953425b154fbe2d63276da0530e 349 Pfam PF10708 Protein of unknown function (DUF2510) 7 39 5.8E-13 T 09-03-2017 IPR018929 Domain of unknown function DUF2510 TK78_RS22340 fe42505caec86477ac55ea0ffb4f4b94 330 Pfam PF13490 Putative zinc-finger 82 109 4.1E-6 T 09-03-2017 IPR027383 Putative zinc-finger TK78_RS25330 e42d26cfb2c90836d179d95b7b621306 102 Pfam PF09707 CRISPR-associated protein (Cas_Cas2CT1978) 2 86 1.1E-31 T 09-03-2017 IPR010152 CRISPR-associated protein Cas2 subtype TK78_RS25330 e42d26cfb2c90836d179d95b7b621306 102 TIGRFAM TIGR01873 cas_CT1978: CRISPR-associated endoribonuclease Cas2, subtype I-E/ECOLI 3 86 5.7E-18 T 09-03-2017 IPR010152 CRISPR-associated protein Cas2 subtype TK78_RS13400 d4ffd1ec83a0ed01b45169abcb20b04c 240 Pfam PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 40 182 1.5E-31 T 09-03-2017 IPR001457 NADH:ubiquinone/plastoquinone oxidoreductase, chain 6 GO:0008137|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TK78_RS28915 f7027eec1c7f29ed0eb18f8f78f09118 184 Pfam PF07331 Tripartite tricarboxylate transporter TctB family 34 176 5.2E-23 T 09-03-2017 IPR009936 Protein of unknown function DUF1468 TK78_RS16825 30cbd62207075c5dc456a44602f25a22 155 SUPERFAMILY SSF55961 48 136 1.96E-7 T 09-03-2017 TK78_RS06230 aa0e88aa25f41d2961bb6f9d51404722 246 Gene3D G3DSA:1.10.530.10 170 222 4.7E-5 T 09-03-2017 TK78_RS06230 aa0e88aa25f41d2961bb6f9d51404722 246 Gene3D G3DSA:1.10.530.10 78 138 4.7E-5 T 09-03-2017 TK78_RS29015 7f15d2b9c0cec8a60bbe999e59bfe39a 352 TIGRFAM TIGR03707 PPK2_P_aer: polyphosphate kinase 2 86 313 2.5E-115 T 09-03-2017 IPR022486 Polyphosphate kinase 2, PA0141 GO:0006793|GO:0008976 TK78_RS29015 7f15d2b9c0cec8a60bbe999e59bfe39a 352 SUPERFAMILY SSF52540 117 303 3.59E-28 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS29015 7f15d2b9c0cec8a60bbe999e59bfe39a 352 Pfam PF03976 Polyphosphate kinase 2 (PPK2) 86 310 4.9E-104 T 09-03-2017 IPR022488 Polyphosphate kinase-2-related TK78_RS29015 7f15d2b9c0cec8a60bbe999e59bfe39a 352 Gene3D G3DSA:3.40.50.300 77 328 5.6E-108 T 09-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase TK78_RS09570 2e04b7b7411ea10cd94857f22edb6e85 259 Pfam PF12730 ABC-2 family transporter protein 8 188 3.7E-8 T 09-03-2017 IPR032688 ABC-2 family transporter protein GO:0006810 TK78_RS27740 d6304ead11c42a918e2e5fab0e53203a 403 Gene3D G3DSA:3.40.640.10 50 278 2.0E-69 T 09-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 TK78_RS27740 d6304ead11c42a918e2e5fab0e53203a 403 SUPERFAMILY SSF53383 4 399 2.42E-97 T 09-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase TK78_RS27740 d6304ead11c42a918e2e5fab0e53203a 403 Gene3D G3DSA:3.90.1150.10 279 402 1.2E-39 T 09-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 TK78_RS27740 d6304ead11c42a918e2e5fab0e53203a 403 Pfam PF00155 Aminotransferase class I and II 34 393 4.3E-53 T 09-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TK78_RS27615 0a8b33cd783e32370ed45dc3e1634208 609 Pfam PF02653 Branched-chain amino acid transport system / permease component 292 577 1.5E-41 T 09-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 TK78_RS15340 63f8129804315feb422befe02bc91dbd 88 Pfam PF14029 Protein of unknown function (DUF4244) 37 85 3.5E-24 T 09-03-2017 IPR025338 Protein of unknown function DUF4244 TK78_RS10565 eee09996e66d121fe7ad4e703b2de793 489 Pfam PF03109 ABC1 family 113 227 2.4E-31 T 09-03-2017 IPR004147 UbiB domain TK78_RS10565 eee09996e66d121fe7ad4e703b2de793 489 SUPERFAMILY SSF56112 195 289 2.81E-19 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS10565 eee09996e66d121fe7ad4e703b2de793 489 SUPERFAMILY SSF56112 95 158 2.81E-19 T 09-03-2017 IPR011009 Protein kinase-like domain TK78_RS23330 8bdc18dfe925f8181e0aeb19b4d0def4 369 Pfam PF01959 3-dehydroquinate synthase (EC 4.6.1.3) 2 369 4.8E-111 T 09-03-2017 IPR002812 3-dehydroquinate synthase GO:0003856|GO:0009073|GO:0016491|GO:0055114 KEGG: 00400+1.4.1.24|MetaCyc: PWY-6160 TK78_RS23330 8bdc18dfe925f8181e0aeb19b4d0def4 369 ProDom PD017907 3-DEHYDROQUINATE UPF0245 SYNTHASE LYASE PREDICTED SYNTHASE-LIKE ALTERNATIVE T19N8 MM1272 MK1408 125 368 1.0E-77 T 09-03-2017 IPR002812 3-dehydroquinate synthase GO:0003856|GO:0009073|GO:0016491|GO:0055114 KEGG: 00400+1.4.1.24|MetaCyc: PWY-6160 TK78_RS15245 99ba96f564ce7f5c4451d788dce868a6 562 Gene3D G3DSA:3.30.565.10 260 387 6.2E-6 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS15245 99ba96f564ce7f5c4451d788dce868a6 562 SUPERFAMILY SSF55874 260 386 4.11E-12 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS15245 99ba96f564ce7f5c4451d788dce868a6 562 Pfam PF07730 Histidine kinase 185 249 5.3E-11 T 09-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 TK78_RS22035 d55e1c96b1412b1842b456678564a051 335 Pfam PF01944 Stage II sporulation protein M 109 283 1.7E-35 T 09-03-2017 IPR002798 Stage II sporulation protein M-like TK78_RS28700 369cb62afe30c467a2b10a408a5153c2 231 Pfam PF10127 Predicted nucleotidyltransferase 13 221 1.9E-39 T 09-03-2017 IPR018775 Nucleotidyltransferase, predicted TK78_RS13845 7eab4d3ab237ad872427b7d4cbfa346d 61 Gene3D G3DSA:3.40.50.1010 26 53 9.9E-4 T 09-03-2017 IPR029060 PIN domain-like TK78_RS11660 c7c0ecafb5a08f146fa644f59ddfbcd1 436 Pfam PF01566 Natural resistance-associated macrophage protein 44 410 1.0E-31 T 09-03-2017 IPR001046 NRAMP family GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-425410 TK78_RS23100 b382a5f9bc5738c99bc33312179f63d4 254 PIRSF PIRSF015736 2 240 7.3E-45 T 09-03-2017 IPR026286 Maleate isomerase/Arylmalonate decarboxylase TK78_RS14935 a5ea3ff33f4f037216b4804e619c37b2 148 Pfam PF08592 Domain of unknown function (DUF1772) 18 146 1.7E-15 T 09-03-2017 IPR013901 Protein of unknown function DUF1772 TK78_RS09220 47f13765a2d61276dc374e1b14dbd7ab 352 Pfam PF05425 Copper resistance protein D 246 339 2.0E-12 T 09-03-2017 IPR008457 Copper resistance protein D GO:0016021 TK78_RS31190 1c77ed40288b2357be8e405079a3fb15 127 Pfam PF11236 Protein of unknown function (DUF3037) 9 126 4.2E-39 T 09-03-2017 IPR021398 Protein of unknown function DUF3037 TK78_RS18905 d4f2c40e051fb66898d52016be7eb2e7 328 Pfam PF06089 L-asparaginase II 22 325 4.4E-112 T 09-03-2017 IPR010349 L-asparaginase II TK78_RS19035 a547e3f7b04c2b33620c6f16b9d1c43d 146 Gene3D G3DSA:1.10.443.10 4 135 3.9E-17 T 09-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 TK78_RS19035 a547e3f7b04c2b33620c6f16b9d1c43d 146 SUPERFAMILY SSF56349 32 128 6.77E-16 T 09-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 TK78_RS19035 a547e3f7b04c2b33620c6f16b9d1c43d 146 Pfam PF00589 Phage integrase family 77 120 6.3E-8 T 09-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 TK78_RS30830 84a51642780e8bbe71e384901bf47521 259 Pfam PF02517 CAAX protease self-immunity 151 240 1.2E-14 T 09-03-2017 IPR003675 CAAX amino terminal protease GO:0016020 TK78_RS03360 d0016f4497acf9b2bcfc2cdbaecfcb9e 372 SUPERFAMILY SSF110296 55 340 1.31E-35 T 09-03-2017 TK78_RS03360 d0016f4497acf9b2bcfc2cdbaecfcb9e 372 Gene3D G3DSA:2.130.10.140 71 349 2.7E-31 T 09-03-2017 TK78_RS16880 1a915efc3641ddfbf86131ec4ae1ef14 238 Pfam PF10935 Protein of unknown function (DUF2637) 13 97 9.2E-6 T 09-03-2017 IPR021235 Protein of unknown function DUF2637 TK78_RS30665 c4e892559123a968ff33e5647b53cb31 145 Pfam PF05331 Protein of unknown function (DUF742) 30 145 6.8E-38 T 09-03-2017 IPR007995 Protein of unknown function DUF742 TK78_RS06480 4304a771d05fbe026c94137debb80c9b 222 Pfam PF09335 SNARE associated Golgi protein 51 179 1.5E-21 T 09-03-2017 IPR032816 SNARE associated Golgi protein TK78_RS03050 ca451a9b377e3cf03f880bd56d9616e5 403 SUPERFAMILY SSF56281 90 328 2.36E-34 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS03050 ca451a9b377e3cf03f880bd56d9616e5 403 Pfam PF12706 Beta-lactamase superfamily domain 116 316 9.5E-51 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS03050 ca451a9b377e3cf03f880bd56d9616e5 403 Gene3D G3DSA:3.60.15.10 87 366 2.3E-102 T 09-03-2017 IPR001279 Metallo-beta-lactamase TK78_RS06105 87df98d3b290dcc7ef8a7bfa56a999a9 162 Gene3D G3DSA:3.40.630.30 68 161 6.4E-20 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS06105 87df98d3b290dcc7ef8a7bfa56a999a9 162 SUPERFAMILY SSF55729 37 136 7.89E-20 T 09-03-2017 IPR016181 Acyl-CoA N-acyltransferase TK78_RS06105 87df98d3b290dcc7ef8a7bfa56a999a9 162 Pfam PF00583 Acetyltransferase (GNAT) family 66 128 1.6E-13 T 09-03-2017 IPR000182 GNAT domain GO:0008080 TK78_RS14640 6c08d02aac29d2d3636562528018526c 1067 Gene3D G3DSA:3.30.565.10 27 228 8.6E-17 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS14640 6c08d02aac29d2d3636562528018526c 1067 SUPERFAMILY SSF55874 48 146 1.3E-7 T 09-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain TK78_RS27135 3d95fd0e45f07460b3346167d93d1008 94 Pfam PF02325 YGGT family 10 90 5.5E-12 T 09-03-2017 IPR003425 CCB3/YggT GO:0016020 TK78_RS30080 c6d1c2ce85d558425d215cff653f5fc6 303 Pfam PF03279 Bacterial lipid A biosynthesis acyltransferase 12 293 6.6E-62 T 09-03-2017 IPR004960 Bacterial lipid A biosynthesis acyltransferase GO:0016021|GO:0016740 TK78_RS25190 2bb4e30879d9ecc9a5e6ce52c07e8d44 210 Gene3D G3DSA:2.40.260.10 67 188 2.2E-5 T 09-03-2017 IPR023365 Sortase domain TK78_RS25190 2bb4e30879d9ecc9a5e6ce52c07e8d44 210 SUPERFAMILY SSF63817 60 208 1.49E-13 T 09-03-2017 IPR023365 Sortase domain TK78_RS25190 2bb4e30879d9ecc9a5e6ce52c07e8d44 210 Pfam PF04203 Sortase family 67 206 1.8E-16 T 09-03-2017 IPR005754 Sortase family TK78_RS17080 8ebf8ec6336748e21627b4e6b1759228 503 Pfam PF01654 Cytochrome bd terminal oxidase subunit I 10 473 1.1E-178 T 09-03-2017 IPR002585 Cytochrome ubiquinol oxidase subunit 1 GO:0016020 TK78_RS18455 b2f719c69a5a14f3da897a806139bfb4 525 SUPERFAMILY SSF48452 283 498 5.31E-5 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS28515 b0ce7e531a719d0cd405664cf483494e 255 Pfam PF01925 Sulfite exporter TauE/SafE 10 251 4.0E-40 T 09-03-2017 IPR002781 Transmembrane protein TauE-like GO:0016021 TK78_RS22380 5b5a06bf610dadadb93891b6c4e5a1b8 98 Pfam PF11238 Protein of unknown function (DUF3039) 26 81 1.7E-32 T 09-03-2017 IPR021400 Protein of unknown function DUF3039 TK78_RS07965 1f659c50909826cdb3604b67c9bc7754 237 Pfam PF13828 Domain of unknown function (DUF4190) 136 201 2.0E-11 T 09-03-2017 IPR025241 Domain of unknown function DUF4190 TK78_RS24030 344ffb6bd88af778b46bf0893dbc485c 252 Pfam PF12679 ABC-2 family transporter protein 58 252 3.1E-12 T 09-03-2017 IPR032688 ABC-2 family transporter protein GO:0006810 TK78_RS16720 3137f33518a7f1374785b0c40b936699 247 Gene3D G3DSA:1.10.260.40 3 61 8.0E-8 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS16720 3137f33518a7f1374785b0c40b936699 247 SUPERFAMILY SSF47413 3 61 7.04E-6 T 09-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 TK78_RS16720 3137f33518a7f1374785b0c40b936699 247 SUPERFAMILY SSF56024 87 175 5.73E-6 T 09-03-2017 TK78_RS13500 1d17500c15b81643c889cd9572ca7109 87 SUPERFAMILY SSF46785 20 82 6.02E-6 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS13500 1d17500c15b81643c889cd9572ca7109 87 Gene3D G3DSA:1.10.10.10 20 83 1.0E-6 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS17405 de71db44f9ea08c42f3f92326deb7b98 206 Pfam PF12089 Transmembrane domain of unknown function (DUF3566) 86 204 8.5E-42 T 09-03-2017 IPR021949 Domain of unknown function DUF3566. transmembrane TK78_RS06495 1e0e9081da7b2048b45f5d9c0f467fe7 355 Gene3D G3DSA:1.10.3470.10 31 352 1.1E-80 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS06495 1e0e9081da7b2048b45f5d9c0f467fe7 355 Pfam PF01032 FecCD transport family 42 348 1.1E-74 T 09-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 TK78_RS06495 1e0e9081da7b2048b45f5d9c0f467fe7 355 SUPERFAMILY SSF81345 26 348 4.05E-64 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS04275 63bb86f82653da82fef47997d59fad39 296 Pfam PF02653 Branched-chain amino acid transport system / permease component 8 279 7.0E-33 T 09-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 TK78_RS31640 1178e0113bfc4331723e8cc30e25efe3 522 Pfam PF00561 alpha/beta hydrolase fold 104 482 1.9E-29 T 09-03-2017 IPR000073 Alpha/beta hydrolase fold-1 TK78_RS31640 1178e0113bfc4331723e8cc30e25efe3 522 Gene3D G3DSA:3.40.50.1820 200 326 1.2E-58 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS31640 1178e0113bfc4331723e8cc30e25efe3 522 Gene3D G3DSA:3.40.50.1820 68 156 1.2E-58 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS31640 1178e0113bfc4331723e8cc30e25efe3 522 Gene3D G3DSA:3.40.50.1820 382 502 1.2E-58 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS31640 1178e0113bfc4331723e8cc30e25efe3 522 SUPERFAMILY SSF53474 335 502 6.8E-24 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS31640 1178e0113bfc4331723e8cc30e25efe3 522 SUPERFAMILY SSF53474 101 157 6.8E-24 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS31640 1178e0113bfc4331723e8cc30e25efe3 522 SUPERFAMILY SSF53474 202 256 6.8E-24 T 09-03-2017 IPR029058 Alpha/Beta hydrolase fold TK78_RS32990 d2c324d4dd8ff6cc6926cd9bb2040d31 67 Gene3D G3DSA:3.40.50.150 5 66 2.0E-7 T 09-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TK78_RS15660 51ce169849e43c7750a6373573cd48af 301 Pfam PF02104 SURF1 family 20 230 2.4E-18 T 09-03-2017 IPR002994 Surfeit locus 1/Shy1 GO:0016020 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TK78_RS04605 29b3a5c474b36728f70747b27b6bf28b 288 Pfam PF09995 Uncharacterized protein conserved in bacteria (DUF2236) 50 280 7.4E-53 T 09-03-2017 IPR018713 Domain of unknown function DUF2236 TK78_RS21435 1af0f4b8fa2009d0081bbc58a976d673 41 Pfam PF04149 Domain of unknown function (DUF397) 2 38 5.4E-13 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS06915 6a8aad3059f8f7962bf21113b4c95cc9 98 Pfam PF13834 Domain of unknown function (DUF4193) 1 97 4.4E-45 T 09-03-2017 IPR025242 Protein of unknown function DUF4193 TK78_RS10345 040be5e33dee5c66ee241fe39f5d95f5 266 Pfam PF06182 ABC-2 family transporter protein 35 265 1.7E-37 T 09-03-2017 IPR010390 Protein of unknown function DUF990 TK78_RS28920 b7c3d957289658107f2025e350b6c34f 509 Pfam PF01970 Tripartite tricarboxylate transporter TctA family 20 437 4.4E-139 T 09-03-2017 IPR002823 Protein of unknown function DUF112, transmembrane TK78_RS27620 d8b9b301e9391eb5637652666fb10258 309 Pfam PF02653 Branched-chain amino acid transport system / permease component 8 293 2.5E-45 T 09-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 TK78_RS08275 71509320f39555af6442eedd0e0ef0b7 204 Pfam PF02620 Uncharacterized ACR, COG1399 58 179 2.1E-33 T 09-03-2017 IPR003772 Protein of unknown function DUF177 TK78_RS33595 c2f79471ece0f9bf5858d15c149f8a05 168 Pfam PF12802 MarR family 33 92 1.5E-7 T 09-03-2017 TK78_RS33595 c2f79471ece0f9bf5858d15c149f8a05 168 SUPERFAMILY SSF46785 18 124 1.74E-12 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS33595 c2f79471ece0f9bf5858d15c149f8a05 168 Gene3D G3DSA:1.10.10.10 17 95 3.1E-14 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS17135 ff51ea900eca2a93dee173b93d41f2cb 105 Gene3D G3DSA:2.60.120.10 2 104 1.0E-23 T 09-03-2017 IPR014710 RmlC-like jelly roll fold TK78_RS17135 ff51ea900eca2a93dee173b93d41f2cb 105 Pfam PF07883 Cupin domain 33 100 7.4E-15 T 09-03-2017 IPR013096 Cupin 2, conserved barrel TK78_RS17135 ff51ea900eca2a93dee173b93d41f2cb 105 SUPERFAMILY SSF51182 23 103 1.57E-19 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS01630 9c0772f7d5709f139e04224d2f2a886b 270 SUPERFAMILY SSF88713 41 212 1.36E-36 T 09-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 TK78_RS01630 9c0772f7d5709f139e04224d2f2a886b 270 Gene3D G3DSA:3.20.20.370 76 210 1.0E-31 T 09-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 TK78_RS01630 9c0772f7d5709f139e04224d2f2a886b 270 Pfam PF01522 Polysaccharide deacetylase 79 210 5.3E-31 T 09-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 TK78_RS07240 212d423f376f48bb02fb038cf220fa8f 530 Pfam PF00474 Sodium:solute symporter family 38 453 2.8E-81 T 09-03-2017 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 TK78_RS10640 41d8846d1b8d6374a9328e22d6efa13b 277 Pfam PF12138 Spherulation-specific family 4 23 270 1.6E-11 T 09-03-2017 IPR021986 Spherulation-specific family 4 TK78_RS25725 d0ff1e645550ce57d96ea695ebee3d6c 149 Pfam PF07681 DoxX 13 87 5.4E-8 T 09-03-2017 IPR032808 DoxX family TK78_RS25785 21d75556c45d10860cab3366ebbcd69d 282 PIRSF PIRSF037395 11 274 7.5E-110 T 09-03-2017 IPR017196 ECF transporter, predicted substrate-specific component UCP037395 TK78_RS25785 21d75556c45d10860cab3366ebbcd69d 282 Pfam PF12822 Protein of unknown function (DUF3816) 81 250 8.7E-21 T 09-03-2017 IPR024529 ECF transporter, substrate-specific component GO:0005215 TK78_RS12380 798b22560542c099d25c71ffe6093944 130 Pfam PF04134 Protein of unknown function, DUF393 1 105 1.9E-10 T 09-03-2017 IPR007263 Protein of unknown function DUF393 TK78_RS20495 1f905d5869a4f5ed2903ce6df7af4b16 154 SUPERFAMILY SSF81901 59 135 7.72E-8 T 09-03-2017 TK78_RS20495 1f905d5869a4f5ed2903ce6df7af4b16 154 Gene3D G3DSA:1.25.40.10 60 135 1.2E-8 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS08620 dc2f9fec694269e0ea0f12674f096fc5 208 SUPERFAMILY SSF160631 66 203 1.7E-8 T 09-03-2017 TK78_RS18635 cb29791be361a07294dd16949e965180 332 Pfam PF01384 Phosphate transporter family 165 320 1.7E-47 T 09-03-2017 IPR001204 Phosphate transporter GO:0005315|GO:0006817|GO:0016020 Reactome: R-HSA-427652 TK78_RS18635 cb29791be361a07294dd16949e965180 332 Pfam PF01384 Phosphate transporter family 20 166 2.0E-39 T 09-03-2017 IPR001204 Phosphate transporter GO:0005315|GO:0006817|GO:0016020 Reactome: R-HSA-427652 TK78_RS02655 eeed63ffccfbf7520df237ac18b4541e 258 Pfam PF06724 Domain of Unknown Function (DUF1206) 187 256 3.5E-19 T 09-03-2017 IPR009597 Domain of unknown function DUF1206 TK78_RS02655 eeed63ffccfbf7520df237ac18b4541e 258 Pfam PF06724 Domain of Unknown Function (DUF1206) 7 75 6.7E-22 T 09-03-2017 IPR009597 Domain of unknown function DUF1206 TK78_RS02655 eeed63ffccfbf7520df237ac18b4541e 258 Pfam PF06724 Domain of Unknown Function (DUF1206) 91 162 1.1E-14 T 09-03-2017 IPR009597 Domain of unknown function DUF1206 TK78_RS14805 92fcb3eb7c4b432c9ed605c3ecfe41a6 96 Pfam PF13223 Protein of unknown function (DUF4031) 4 77 4.0E-31 T 09-03-2017 IPR025109 Domain of unknown function DUF4031 TK78_RS12620 e34da435d8e0d5b0af6eab72b7169796 170 Pfam PF07681 DoxX 26 128 7.8E-21 T 09-03-2017 IPR032808 DoxX family TK78_RS30690 7c0255bed522b3faefaff9ec7f8bb6e2 120 Pfam PF06127 Protein of unknown function (DUF962) 6 99 1.3E-25 T 09-03-2017 IPR009305 Protein of unknown function DUF962 TK78_RS05450 f14c9f8c899bf7eaf518290cc2bc77bc 120 Pfam PF14087 Domain of unknown function (DUF4267) 5 107 2.8E-8 T 09-03-2017 IPR025363 Protein of unknown function DUF4267 TK78_RS17675 66ac2648de3fffefbc886d171c89ea54 951 Pfam PF02687 FtsX-like permease family 304 418 1.5E-8 T 09-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 TK78_RS12950 874b4a1b201c1949a62e26e971e7a8a4 63 Pfam PF04149 Domain of unknown function (DUF397) 7 60 8.3E-22 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS07425 886d26e5755ac0808769817749d65bed 246 SUPERFAMILY SSF53213 7 245 7.06E-9 T 09-03-2017 IPR004183 Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B GO:0006725|GO:0008198|GO:0016491 TK78_RS08325 e77d4d6ffe96d757e29de1cfb70b86b8 162 Pfam PF12028 Protein of unknown function (DUF3515) 20 160 1.0E-27 T 09-03-2017 IPR021903 Protein of unknown function DUF3515 TK78_RS11485 8e34ff1d5333e580512c406138922b3d 797 Pfam PF02687 FtsX-like permease family 222 336 1.0E-7 T 09-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 TK78_RS11485 8e34ff1d5333e580512c406138922b3d 797 Pfam PF02687 FtsX-like permease family 680 786 9.0E-9 T 09-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 TK78_RS24895 71abc0ee3ff100c83ea64bc95bf81aee 299 SUPERFAMILY SSF81345 5 261 1.57E-36 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS24895 71abc0ee3ff100c83ea64bc95bf81aee 299 Gene3D G3DSA:1.10.3470.10 43 262 3.4E-12 T 09-03-2017 IPR029022 ABC transporter, BtuC-like TK78_RS24895 71abc0ee3ff100c83ea64bc95bf81aee 299 Pfam PF00950 ABC 3 transport family 9 262 1.3E-64 T 09-03-2017 IPR001626 ABC transporter, TroCD-like GO:0005887|GO:0042626|GO:0043190|GO:0055085 TK78_RS11055 4ea8b57e972dfe1eb9fbe567cf1818ba 425 Pfam PF06772 Bacterial low temperature requirement A protein (LtrA) 34 399 6.5E-83 T 09-03-2017 IPR010640 Low temperature requirement A TK78_RS13245 0faaf5d719884beb170a8e26ec272314 301 SUPERFAMILY SSF89392 105 274 1.02E-10 T 09-03-2017 IPR029046 Lipoprotein localisation LolA/LolB/LppX TK78_RS23955 bb7be20dc44923fafb57b78eda728299 206 Pfam PF14124 Domain of unknown function (DUF4291) 11 188 4.4E-67 T 09-03-2017 IPR025633 Protein of unknown function DUF4291 TK78_RS03425 a18ec872da2f889237d4651a9e971db9 338 Pfam PF01896 DNA primase small subunit 131 251 1.7E-8 T 09-03-2017 IPR002755 DNA primase, small subunit GO:0003896|GO:0006269 Reactome: R-HSA-113501|Reactome: R-HSA-174411|Reactome: R-HSA-174430|Reactome: R-HSA-68952|Reactome: R-HSA-68962|Reactome: R-HSA-69091|Reactome: R-HSA-69109|Reactome: R-HSA-69166|Reactome: R-HSA-69183 TK78_RS03425 a18ec872da2f889237d4651a9e971db9 338 TIGRFAM TIGR02778 ligD_pol: DNA ligase D, polymerase domain 10 255 2.0E-69 T 09-03-2017 IPR014145 DNA ligase D, polymerase domain TK78_RS00435 b547586bfa687528aec1e1361c4c5a8e 418 Pfam PF02653 Branched-chain amino acid transport system / permease component 72 402 1.4E-33 T 09-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 TK78_RS22555 560ffa96f84a8892a8db46010987f32c 222 Pfam PF06271 RDD family 70 215 9.8E-24 T 09-03-2017 IPR010432 RDD TK78_RS03555 ccc6000af6e2d3581e785afff667f26d 286 SUPERFAMILY SSF56059 119 254 8.11E-8 T 09-03-2017 TK78_RS22830 03024ddef2db676331eaa086aded3bbd 68 Pfam PF04149 Domain of unknown function (DUF397) 11 62 3.9E-18 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS20640 d23d6192c33417b979f17e57ca6850f3 68 Pfam PF04149 Domain of unknown function (DUF397) 10 61 7.5E-22 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS27045 db8ab83cf58a5ca499a648294f317209 455 Pfam PF01882 Protein of unknown function DUF58 219 297 3.6E-20 T 09-03-2017 IPR002881 Domain of unknown function DUF58 TK78_RS21710 56c68530cfa7bcd519c0fa08023cb98f 268 Gene3D G3DSA:1.10.10.10 184 228 8.0E-4 T 09-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain TK78_RS11870 88685875e99957194b70f08cc91c618b 65 Pfam PF06348 Protein of unknown function (DUF1059) 4 57 1.3E-12 T 09-03-2017 IPR009409 Protein of unknown function DUF1059 TK78_RS25715 04648c090775b0e176c835bf2108b443 221 Pfam PF09335 SNARE associated Golgi protein 64 170 9.1E-10 T 09-03-2017 IPR032816 SNARE associated Golgi protein TK78_RS03490 847239439c7f460c6c32ef04d4730c80 343 TIGRFAM TIGR00996 Mtu_fam_mce: virulence factor Mce family protein 14 298 1.7E-65 T 09-03-2017 IPR005693 Virulence factor Mce protein TK78_RS03490 847239439c7f460c6c32ef04d4730c80 343 Pfam PF02470 MlaD protein 38 114 2.2E-16 T 09-03-2017 IPR003399 Mce/MlaD TK78_RS27580 ba45b963ef603f9922a606d3b14e608a 238 Pfam PF04402 Protein of unknown function (DUF541) 21 230 3.3E-31 T 09-03-2017 IPR007497 Protein of unknown function DUF541 TK78_RS09660 a707a028bd58159b4d945c30a9c54bfe 148 Pfam PF10739 Protein of unknown function (DUF2550) 12 142 2.7E-42 T 09-03-2017 IPR019675 Protein of unknown function DUF2550 TK78_RS18440 f7f5a883793bdf6ee7fd3a95b3c15910 507 Pfam PF13367 Protease prsW family 109 307 2.8E-52 T 09-03-2017 IPR026898 Protease PrsW GO:0008233 TK78_RS12180 75b29281f8426e82427ceb9199db49e6 372 Pfam PF02653 Branched-chain amino acid transport system / permease component 58 335 1.1E-43 T 09-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 TK78_RS14620 286e950cf84345d03cc99b7eb487fa38 113 Pfam PF10745 Protein of unknown function (DUF2530) 11 71 3.7E-5 T 09-03-2017 IPR019681 Protein of unknown function DUF2530 TK78_RS08030 79d7fb480eda511fe38093dcdd59b9f3 404 Pfam PF09594 Protein of unknown function (DUF2029) 128 366 9.1E-6 T 09-03-2017 IPR018584 Glycosyltransferase family 87 GO:0016758 TK78_RS23810 9ad9710e57ea61e48c9d4affb30d0603 139 Pfam PF12647 RNHCP domain 30 118 3.3E-33 T 09-03-2017 IPR024439 RNHCP domain TK78_RS09005 e6a7974a88752a9da8c2588c320da667 453 Pfam PF01554 MatE 237 393 1.5E-11 T 09-03-2017 IPR002528 Multi antimicrobial extrusion protein GO:0006855|GO:0015238|GO:0015297|GO:0016020|GO:0055085 Reactome: R-HSA-425366 TK78_RS09005 e6a7974a88752a9da8c2588c320da667 453 Pfam PF01554 MatE 18 175 7.0E-12 T 09-03-2017 IPR002528 Multi antimicrobial extrusion protein GO:0006855|GO:0015238|GO:0015297|GO:0016020|GO:0055085 Reactome: R-HSA-425366 TK78_RS33350 e2cb29f0e3505b5a814dfffb7c24c025 244 Pfam PF01955 Adenosylcobinamide amidohydrolase 54 236 1.2E-49 T 09-03-2017 IPR002808 Adenosylcobinamide amidohydrolase, CbiZ TK78_RS08205 d21624b5626c0381b419058fe6cba697 491 Gene3D G3DSA:1.25.40.10 252 447 2.5E-9 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS08205 d21624b5626c0381b419058fe6cba697 491 SUPERFAMILY SSF48452 412 449 4.3E-8 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS08205 d21624b5626c0381b419058fe6cba697 491 SUPERFAMILY SSF48452 234 352 4.3E-8 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS25600 27d53b65b3140a6d171b986c5f3569ed 145 Pfam PF11253 Protein of unknown function (DUF3052) 15 139 1.2E-56 T 09-03-2017 IPR021412 Protein of unknown function DUF3052 TK78_RS23840 160e2c39c982d4db0946898601ae98e1 476 Pfam PF13699 Domain of unknown function (DUF4157) 90 161 5.1E-26 T 09-03-2017 IPR025295 Domain of unknown function DUF4157 TK78_RS32645 69d00f60da3aa94f042c83d210120a60 497 Pfam PF08309 LVIVD repeat 95 127 0.0012 T 09-03-2017 IPR013211 LVIVD TK78_RS32645 69d00f60da3aa94f042c83d210120a60 497 SUPERFAMILY SSF75011 173 464 1.83E-9 T 09-03-2017 TK78_RS06125 bdebe9b273ae16ff1e348f3afa8ba6a5 126 Pfam PF08937 MTH538 TIR-like domain (DUF1863) 45 106 3.5E-5 T 09-03-2017 IPR015032 MTH538 TIR-like domain TK78_RS20795 99b35bd9abe0897b79129a0910db4f49 341 Pfam PF14027 Protein of unknown function (DUF4243) 26 317 1.8E-28 T 09-03-2017 IPR025337 Domain of unknown function DUF4243 TK78_RS22890 e16b33d6ebe432a30be53c9a033db7be 985 Pfam PF10593 Z1 domain 475 724 7.1E-63 T 09-03-2017 IPR018310 Putative endonuclease, Z1 domain TK78_RS11110 4c9bebdbe056aafcc344d564e8f1f779 71 Pfam PF04149 Domain of unknown function (DUF397) 9 64 1.7E-21 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS25185 dfd26bb3890dbcfa0f88780565d3e575 263 Pfam PF01925 Sulfite exporter TauE/SafE 13 255 2.0E-36 T 09-03-2017 IPR002781 Transmembrane protein TauE-like GO:0016021 TK78_RS25570 336d2aae37793f36f0aa67af28525934 322 Pfam PF14472 Domain of unknown function (DUF4429) 139 262 2.9E-38 T 09-03-2017 IPR027860 Domain of unknown function DUF4429 TK78_RS25570 336d2aae37793f36f0aa67af28525934 322 Pfam PF14472 Domain of unknown function (DUF4429) 12 106 2.6E-15 T 09-03-2017 IPR027860 Domain of unknown function DUF4429 TK78_RS29245 c723b461a4204d2295fda21b868f0dbb 279 TIGRFAM TIGR03843 TIGR03843: conserved hypothetical protein 21 279 1.8E-104 T 09-03-2017 IPR022292 Conserved hypothetical protein CHP03843 TK78_RS15105 ba8633d51ce8ad18c3706eee56cad3c8 225 SUPERFAMILY SSF51182 21 158 1.25E-7 T 09-03-2017 IPR011051 RmlC-like cupin domain TK78_RS31655 ed85e9083b1f6a5b032b08df0b5550fd 316 Pfam PF09678 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) 38 280 1.1E-83 T 09-03-2017 IPR019108 Cytochrome c oxidase caa3-type, assembly factor CtaG-related TK78_RS29145 a866d9fd332e1f5a052281ad0aa0753e 522 PIRSF PIRSF006060 22 512 5.7E-51 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS29145 a866d9fd332e1f5a052281ad0aa0753e 522 Pfam PF13520 Amino acid permease 44 453 3.3E-20 T 09-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 TK78_RS04545 e75565327605ae9abe318abf00783773 324 Pfam PF15575 Immunity protein 49 65 297 7.7E-34 T 09-03-2017 IPR029074 Immunity protein 49 TK78_RS31710 0265e26f246de1796bf06188ac93ca65 487 Pfam PF10009 Uncharacterized protein conserved in bacteria (DUF2252) 59 462 1.4E-139 T 09-03-2017 IPR018721 Protein of unknown function DUF2252 TK78_RS31215 4630f0b31fa1a61cf9531d8055313f64 157 Gene3D G3DSA:1.25.40.10 28 130 9.9E-4 T 09-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 TK78_RS31735 30ea8e7ac52d8faffa2a1b8e1f276645 263 Pfam PF04307 LexA-binding, inner membrane-associated putative hydrolase 1 256 1.8E-35 T 09-03-2017 IPR007404 LexA-binding, inner membrane-associated putative hydrolase TK78_RS27655 62ce5df363db42c10c48e2ba17e59271 321 Pfam PF11271 Protein of unknown function (DUF3068) 6 307 8.8E-81 T 09-03-2017 IPR021424 Protein of unknown function DUF3068 TK78_RS27790 67c9beeab872c822e372ec2be5522ca1 276 Pfam PF03707 Bacterial signalling protein N terminal repeat 56 115 2.4E-12 T 09-03-2017 IPR005330 MHYT domain TK78_RS27790 67c9beeab872c822e372ec2be5522ca1 276 Pfam PF03707 Bacterial signalling protein N terminal repeat 120 172 8.3E-15 T 09-03-2017 IPR005330 MHYT domain TK78_RS28770 a9313a73a8d04ea3952119bbe7c218f9 71 Pfam PF11720 Peptidase inhibitor I78 family 27 63 4.1E-6 T 09-03-2017 IPR021719 Proteinase inhibitor I78 TK78_RS26430 30f933da3360312d21095f52e11ba31c 519 Pfam PF09362 Domain of unknown function (DUF1996) 275 498 6.2E-29 T 09-03-2017 IPR018535 Domain of unknown function DUF1996 TK78_RS01225 9f02eb05fbb5d63395758900e146b506 142 Gene3D G3DSA:1.20.5.100 76 121 5.7E-4 T 09-03-2017 TK78_RS03870 44fd200e742574bdd3f757938276ad0a 641 Pfam PF03235 Protein of unknown function DUF262 12 212 6.1E-28 T 09-03-2017 IPR004919 Domain of unknown function DUF262 TK78_RS11135 4cab1941a47fb0df6f95c852c8178186 53 Pfam PF04149 Domain of unknown function (DUF397) 20 46 1.4E-6 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS02080 2dd98d7e834eb1dd6f5b30e98e78407c 200 Pfam PF13358 DDE superfamily endonuclease 15 167 8.7E-25 T 09-03-2017 TK78_RS16900 b76441dca30230ed3ea258c8a0bb1906 469 Pfam PF09376 NurA domain 65 258 8.2E-6 T 09-03-2017 IPR018977 NurA domain TK78_RS23550 ac0685e73835100412abcb183dfe172b 69 Pfam PF04149 Domain of unknown function (DUF397) 9 63 1.4E-20 T 09-03-2017 IPR007278 Domain of unknown function DUF397 TK78_RS19470 2d536bc56fffab0a92583c820dc9f472 93 Pfam PF11662 Protein of unknown function (DUF3263) 21 93 1.3E-28 T 09-03-2017 IPR021678 Protein of unknown function DUF3263 TK78_RS05295 f2f09b82424362a771230d3f7be1cf01 282 Pfam PF11575 FhuF 2Fe-2S C-terminal domain 248 268 5.4E-6 T 09-03-2017 IPR024726 Ferric iron reductase, C-terminal GO:0051537 TK78_RS00335 dbe58cd6c7ccfbff1d5b4fd26a233368 158 Pfam PF13340 Putative transposase of IS4/5 family (DUF4096) 23 94 4.7E-30 T 09-03-2017 IPR025161 Putative transposase IS4/IS5 family TK78_RS03725 5098924ee7a795be51c7dbbfb7262bbf 281 TIGRFAM TIGR04267 mod_HExxH: HEXXH motif domain 2 90 1.2E-17 T 09-03-2017 IPR026337 HEXXH motif domain TK78_RS31305 d256e1a36c281e10f2c355b14bd5c7eb 240 Pfam PF09335 SNARE associated Golgi protein 81 198 1.7E-24 T 09-03-2017 IPR032816 SNARE associated Golgi protein TK78_RS24435 68cdce964f2c210ef88e7a88bd21aa75 117 Pfam PF14017 Protein of unknown function (DUF4233) 2 104 3.4E-33 T 09-03-2017 IPR025327 Protein of unknown function DUF4233 TK78_RS29450 dd703d8225348b1162c17a7ff6b5205b 240 Pfam PF07103 Protein of unknown function (DUF1365) 4 232 1.9E-60 T 09-03-2017 IPR010775 Protein of unknown function DUF1365 TK78_RS10555 48691d98718fb82543b98b9c18c59641 207 Pfam PF01863 Protein of unknown function DUF45 95 184 3.5E-23 T 09-03-2017 IPR002725 Protein of unknown function DUF45 TK78_RS29115 401fd45000766dc6a79c6ac8a9b38a3d 104 Pfam PF02656 Domain of unknown function (DUF202) 8 68 1.7E-10 T 09-03-2017 IPR003807 Domain of unknown function DUF202 TK78_RS14300 1d3c36514e260b662551fd4b5a05ae9e 137 Pfam PF14078 Domain of unknown function (DUF4259) 2 122 7.9E-29 T 09-03-2017 IPR025355 Protein of unknown function DUF4259 TK78_RS05445 6a3c3721b29110d86e2c3e7827d732bb 186 Pfam PF07681 DoxX 7 98 1.0E-12 T 09-03-2017 IPR032808 DoxX family TK78_RS34245 0ae60c10d62908f76411a27b19826030 224 Pfam PF14021 Protein of unknown function (DUF4237) 119 220 9.6E-32 T 09-03-2017 IPR025331 Protein of unknown function DUF4237 TK78_RS07510 2b382a3edc3080dbafa38df7c313af93 388 Pfam PF01594 Domain of unknown function DUF20 15 335 9.7E-75 T 09-03-2017 IPR002549 Transmembrane protein TqsA-like TK78_RS10730 056332a4189a0bfea70148d5ed1392fc 194 Pfam PF05076 Suppressor of fused protein (SUFU) 29 188 1.0E-30 T 09-03-2017 IPR020941 Suppressor of fused-like domain Reactome: R-HSA-5610780|Reactome: R-HSA-5610783|Reactome: R-HSA-5610785|Reactome: R-HSA-5610787|Reactome: R-HSA-5632684 TK78_RS31950 783d1de162fbba640743d20b6ee3dc44 6266 SUPERFAMILY SSF81298 1974 2124 2.48E-5 T 09-03-2017 TK78_RS30010 19fc66620938e0aec9d1e8c0b5dc0697 137 Pfam PF04686 Streptomyces sporulation and cell division protein, SsgA 23 120 3.5E-38 T 09-03-2017 IPR006776 Sporulation-specific cell division protein SsgB GO:0051301 TK78_RS12215 0d79e6d24dc60848c0a7149ced0cfe75 462 SUPERFAMILY SSF53756 94 323 3.11E-5 T 09-03-2017 TK78_RS16150 57ad8994b42b4047f2b6ac5bf2d22ee9 81 Pfam PF07362 Post-segregation antitoxin CcdA 6 41 8.9E-5 T 09-03-2017 IPR009956 Post-segregation antitoxin CcdA