locus-tag	class	description
EZV63_RS00255	COG1819	glycosyl
EZV63_RS00265	COG0277	FAD linked oxidase domain protein
EZV63_RS00305	COG0667	Aldo Keto reductase
EZV63_RS00310	COG2124	cytochrome p450
EZV63_RS00315	COG0477	Major facilitator Superfamily
EZV63_RS00340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EZV63_RS00350	COG1309	transcriptional regulator
EZV63_RS00380	COG0165	Argininosuccinate lyase
EZV63_RS00395	COG1834	amidinotransferase
EZV63_RS00405	COG1024	Enoyl-CoA hydratase
EZV63_RS00410	COG1024	Enoyl-CoA hydratase
EZV63_RS00420	COG2175	clavaminate synthase activity
EZV63_RS00590	COG4257	antibiotic catabolic process
EZV63_RS00610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZV63_RS00615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZV63_RS00630	COG2814	Major facilitator Superfamily
EZV63_RS00640	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EZV63_RS00645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZV63_RS00660	COG4989	oxidoreductase activity
EZV63_RS00665	COG0667	Aldo Keto reductase
EZV63_RS00670	COG3250	beta-galactosidase activity
EZV63_RS00680	COG1172	Belongs to the binding-protein-dependent transport system permease family
EZV63_RS00685	COG1172	Belongs to the binding-protein-dependent transport system permease family
EZV63_RS00690	COG1129	ABC transporter
EZV63_RS00705	COG2272	Belongs to the type-B carboxylesterase lipase family
EZV63_RS00740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EZV63_RS00750	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EZV63_RS00775	COG0406	alpha-ribazole phosphatase activity
EZV63_RS00780	COG4948	Mandelate Racemase Muconate Lactonizing
EZV63_RS00805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EZV63_RS00825	COG0477	Major facilitator Superfamily
EZV63_RS00845	COG0367	asparagine synthase
EZV63_RS00860	COG2353	YceI-like domain
EZV63_RS00875	COG1120	ATPase activity
EZV63_RS00880	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZV63_RS00885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZV63_RS00905	COG0583	DNA-binding transcription factor activity
EZV63_RS00910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZV63_RS00960	COG0477	Major facilitator Superfamily
EZV63_RS00965	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS01005	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS01010	COG1309	transcriptional regulator
EZV63_RS01015	COG1278	Cold shock
EZV63_RS01030	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS01060	COG0739	heme binding
EZV63_RS01065	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
EZV63_RS01090	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EZV63_RS01100	COG1309	transcriptional regulator
EZV63_RS01105	COG0154	amidase activity
EZV63_RS01160	COG1737	Transcriptional regulator
EZV63_RS01165	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EZV63_RS01170	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EZV63_RS01180	COG1349	DNA-binding transcription factor activity
EZV63_RS01195	COG3395	kinase activity
EZV63_RS01200	COG0235	Class ii aldolase
EZV63_RS01260	COG0765	amino acid transport
EZV63_RS01280	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS01320	COG0601	transmembrane transport
EZV63_RS01340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZV63_RS01355	COG0431	NADPH-dependent FMN reductase
EZV63_RS01385	COG0714	Associated with various cellular activities
EZV63_RS01390	COG2425	protein containing a von Willebrand factor type A (vWA) domain
EZV63_RS01425	COG0494	nUDIX hydrolase
EZV63_RS01445	COG0583	DNA-binding transcription factor activity
EZV63_RS01475	COG4608	Belongs to the ABC transporter superfamily
EZV63_RS01480	COG0444	Belongs to the ABC transporter superfamily
EZV63_RS01490	COG0601	transmembrane transport
EZV63_RS01495	COG0747	negative chemotaxis
EZV63_RS01500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EZV63_RS01505	COG4948	Mandelate Racemase Muconate Lactonizing
EZV63_RS01510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EZV63_RS01515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZV63_RS01520	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EZV63_RS01525	COG3119	arylsulfatase activity
EZV63_RS01560	COG2239	Acts as a magnesium transporter
EZV63_RS01575	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EZV63_RS01580	COG2409	Drug exporters of the RND superfamily
EZV63_RS01590	COG2205	protein histidine kinase activity
EZV63_RS01595	COG0745	RESPONSE REGULATOR receiver
EZV63_RS01625	COG3226	Transcriptional regulator
EZV63_RS01630	COG2391	methyltransferase activity
EZV63_RS01640	COG0326	Molecular chaperone. Has ATPase activity
EZV63_RS01650	COG2205	protein histidine kinase activity
EZV63_RS01660	COG2159	amidohydrolase
EZV63_RS01670	COG0477	Major facilitator Superfamily
EZV63_RS01670	COG2814	Major facilitator Superfamily
EZV63_RS01680	COG4977	sequence-specific DNA binding
EZV63_RS01700	COG2175	clavaminate synthase activity
EZV63_RS01710	COG0395	ABC-type sugar transport system, permease component
EZV63_RS01715	COG1175	transmembrane transport
EZV63_RS01725	COG1609	Transcriptional regulator
EZV63_RS01730	COG3940	Belongs to the glycosyl hydrolase 43 family
EZV63_RS01735	COG1953	Uracil, thiamine, allantoin
EZV63_RS01760	COG3415	Transposase
EZV63_RS01760	COG2801	Transposase and inactivated derivatives
EZV63_RS01795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EZV63_RS01805	COG3396	Phenylacetate-CoA oxygenase
EZV63_RS01810	COG3460	Phenylacetate-CoA oxygenase
EZV63_RS01815	COG3396	Phenylacetate-CoA oxygenase
EZV63_RS01820	COG2050	protein possibly involved in aromatic compounds catabolism
EZV63_RS01875	COG1119	ATPase activity
EZV63_RS01890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZV63_RS01895	COG2188	Transcriptional regulator
EZV63_RS01905	COG1335	isochorismatase
EZV63_RS01960	COG0583	DNA-binding transcription factor activity
EZV63_RS01975	COG2814	Major facilitator Superfamily
EZV63_RS01985	COG0583	DNA-binding transcription factor activity
EZV63_RS01990	COG5640	endopeptidase activity
EZV63_RS02005	COG1017	nitric oxide dioxygenase activity
EZV63_RS02005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EZV63_RS02010	COG1959	2 iron, 2 sulfur cluster binding
EZV63_RS02020	COG1136	(ABC) transporter
EZV63_RS02020	COG0577	efflux transmembrane transporter activity
EZV63_RS02030	COG4585	Histidine kinase
EZV63_RS02035	COG2197	response regulator
EZV63_RS02040	COG2814	Major facilitator Superfamily
EZV63_RS02075	COG0028	Belongs to the TPP enzyme family
EZV63_RS02080	COG1609	Transcriptional regulator
EZV63_RS02085	COG4209	transmembrane transport
EZV63_RS02090	COG0395	ABC-type sugar transport system, permease component
EZV63_RS02120	COG4607	ABC-type enterochelin transport system periplasmic component
EZV63_RS02125	COG1120	ATPase activity
EZV63_RS02130	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZV63_RS02135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZV63_RS02145	COG1120	ATPase activity
EZV63_RS02160	COG1073	alpha beta
EZV63_RS02200	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
EZV63_RS02235	COG0475	glutathione-regulated potassium exporter activity
EZV63_RS02280	COG0243	molybdopterin cofactor binding
EZV63_RS02295	COG1088	dTDP-glucose 4,6-dehydratase activity
EZV63_RS02320	COG0753	catalase activity
EZV63_RS02340	COG0009	L-threonylcarbamoyladenylate synthase
EZV63_RS02360	COG0656	L-ascorbic acid biosynthetic process
EZV63_RS02385	COG2382	esterase
EZV63_RS02390	COG1169	isochorismate synthase
EZV63_RS02400	COG3433	isochorismatase activity
EZV63_RS02400	COG1535	isochorismatase
EZV63_RS02415	COG3285	dna ligase
EZV63_RS02415	COG1793	dna ligase
EZV63_RS02425	COG0181	hydroxymethylbilane synthase activity
EZV63_RS02435	COG1191	sigma factor activity
EZV63_RS02465	COG0366	Alpha amylase catalytic
EZV63_RS02470	COG0366	Alpha amylase catalytic
EZV63_RS02480	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EZV63_RS02515	COG5002	protein histidine kinase activity
EZV63_RS02515	COG0784	Response regulator, receiver
EZV63_RS02515	COG2205	protein histidine kinase activity
EZV63_RS02530	COG1366	Belongs to the anti-sigma-factor antagonist family
EZV63_RS02535	COG1366	Belongs to the anti-sigma-factor antagonist family
EZV63_RS02540	COG2172	sigma factor antagonist activity
EZV63_RS02555	COG1252	NADH dehydrogenase
EZV63_RS02595	COG1982	Orn Lys Arg decarboxylase major
EZV63_RS02605	COG0477	Major facilitator Superfamily
EZV63_RS02625	COG3189	MarR family transcriptional regulator
EZV63_RS02645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EZV63_RS02675	COG2197	response regulator
EZV63_RS02680	COG2340	Cysteine-rich secretory protein family
EZV63_RS02690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EZV63_RS02695	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EZV63_RS02695	COG0515	serine threonine protein kinase
EZV63_RS02700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZV63_RS02720	COG0667	Aldo Keto reductase
EZV63_RS02730	COG0328	RNA-DNA hybrid ribonuclease activity
EZV63_RS02740	COG0740	serine-type endopeptidase activity
EZV63_RS02745	COG0740	serine-type endopeptidase activity
EZV63_RS02785	COG0667	Aldo Keto reductase
EZV63_RS02790	COG0583	DNA-binding transcription factor activity
EZV63_RS02800	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EZV63_RS02805	COG0346	lactoylglutathione lyase activity
EZV63_RS02835	COG0673	inositol 2-dehydrogenase activity
EZV63_RS02875	COG0318	PFAM AMP-dependent synthetase and ligase
EZV63_RS02880	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EZV63_RS02920	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EZV63_RS02930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EZV63_RS02995	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS03000	COG2072	flavoprotein involved in K transport
EZV63_RS03015	COG1940	carbohydrate kinase activity
EZV63_RS03025	COG1175	transmembrane transport
EZV63_RS03030	COG0395	ABC-type sugar transport system, permease component
EZV63_RS03045	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EZV63_RS03060	COG0583	DNA-binding transcription factor activity
EZV63_RS03065	COG0667	Aldo Keto reductase
EZV63_RS03070	COG2223	nitrite transmembrane transporter activity
EZV63_RS03085	COG1216	Glycosyl transferase, family 2
EZV63_RS03105	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EZV63_RS03110	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EZV63_RS03125	COG2376	Dihydroxyacetone kinase
EZV63_RS03130	COG1461	Dihydroxyacetone kinase
EZV63_RS03160	COG1902	pentaerythritol trinitrate reductase activity
EZV63_RS03160	COG0446	pyridine nucleotide-disulphide oxidoreductase
EZV63_RS03180	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EZV63_RS03195	COG3458	cephalosporin-C deacetylase activity
EZV63_RS03200	COG2188	Transcriptional regulator
EZV63_RS03205	COG2226	methyltransferase
EZV63_RS03220	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EZV63_RS03235	COG1968	undecaprenyl-diphosphatase activity
EZV63_RS03240	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EZV63_RS03245	COG1993	acr, cog1993
EZV63_RS03250	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EZV63_RS03255	COG1846	Transcriptional regulator
EZV63_RS03270	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
EZV63_RS03280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZV63_RS03290	COG3458	cephalosporin-C deacetylase activity
EZV63_RS03300	COG0747	negative chemotaxis
EZV63_RS03310	COG0444	Belongs to the ABC transporter superfamily
EZV63_RS03330	COG0137	argininosuccinate synthase activity
EZV63_RS03350	COG1472	Belongs to the glycosyl hydrolase 3 family
EZV63_RS03360	COG1175	transmembrane transport
EZV63_RS03365	COG1653	transport
EZV63_RS03370	COG1609	Transcriptional regulator
EZV63_RS03390	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EZV63_RS03395	COG0463	Glycosyl transferase, family 2
EZV63_RS03430	COG1349	DNA-binding transcription factor activity
EZV63_RS03465	COG1940	carbohydrate kinase activity
EZV63_RS03475	COG2813	Specifically methylates the guanine in position
EZV63_RS03480	COG0191	fructose-bisphosphate aldolase activity
EZV63_RS03485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EZV63_RS03500	COG0783	Belongs to the Dps family
EZV63_RS03515	COG1501	Belongs to the glycosyl hydrolase 31 family
EZV63_RS03525	COG1175	transmembrane transport
EZV63_RS03530	COG0395	ABC-type sugar transport system, permease component
EZV63_RS03535	COG2723	6-phospho-beta-galactosidase activity
EZV63_RS03550	COG2197	response regulator
EZV63_RS03555	COG4585	Histidine kinase
EZV63_RS03560	COG0445	tRNA wobble uridine modification
EZV63_RS03565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EZV63_RS03570	COG1660	Displays ATPase and GTPase activities
EZV63_RS03600	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EZV63_RS03640	COG0584	glycerophosphoryl diester phosphodiesterase
EZV63_RS03670	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS03680	COG1053	succinate dehydrogenase
EZV63_RS03735	COG0671	phosphoesterase, PA-phosphatase related
EZV63_RS03770	COG1960	acyl-CoA dehydrogenase activity
EZV63_RS03785	COG0601	transmembrane transport
EZV63_RS03805	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EZV63_RS03810	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EZV63_RS03815	COG2971	BadF BadG BcrA BcrD
EZV63_RS03840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EZV63_RS03870	COG4221	oxidoreductase activity
EZV63_RS03895	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EZV63_RS03900	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EZV63_RS03905	COG2080	2 iron, 2 sulfur cluster binding
EZV63_RS03915	COG4565	transcriptional regulatory protein
EZV63_RS03920	COG3290	protein histidine kinase activity
EZV63_RS03945	COG0432	Pfam Uncharacterised protein family UPF0047
EZV63_RS03950	COG2072	flavoprotein involved in K transport
EZV63_RS03960	COG1132	(ABC) transporter
EZV63_RS03980	COG1132	(ABC) transporter
EZV63_RS03990	COG0254	rRNA binding
EZV63_RS04005	COG1946	Acyl-CoA thioesterase
EZV63_RS04015	COG2018	Roadblock/LC7 domain
EZV63_RS04045	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EZV63_RS04055	COG2115	Belongs to the xylose isomerase family
EZV63_RS04060	COG1070	Carbohydrate kinase
EZV63_RS04065	COG1940	carbohydrate kinase activity
EZV63_RS04065	COG1846	Transcriptional regulator
EZV63_RS04080	COG1012	belongs to the aldehyde dehydrogenase family
EZV63_RS04125	COG1522	sequence-specific DNA binding
EZV63_RS04150	COG1609	Transcriptional regulator
EZV63_RS04160	COG1175	transmembrane transport
EZV63_RS04170	COG1472	Belongs to the glycosyl hydrolase 3 family
EZV63_RS04175	COG0129	dihydroxy-acid dehydratase activity
EZV63_RS04220	COG0477	Major facilitator Superfamily
EZV63_RS04245	COG1960	acyl-CoA dehydrogenase activity
EZV63_RS04250	COG1960	acyl-CoA dehydrogenase activity
EZV63_RS04260	COG1396	sequence-specific DNA binding
EZV63_RS04260	COG3800	Transcriptional regulator
EZV63_RS04270	COG1793	dna ligase
EZV63_RS04280	COG1012	belongs to the aldehyde dehydrogenase family
EZV63_RS04290	COG3424	synthase
EZV63_RS04295	COG2124	cytochrome p450
EZV63_RS04305	COG1960	acyl-CoA dehydrogenase activity
EZV63_RS04315	COG0242	peptide deformylase activity
EZV63_RS04320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EZV63_RS04325	COG3442	glutamine amidotransferase
EZV63_RS04330	COG0205	6-phosphofructokinase activity
EZV63_RS04345	COG3275	phosphorelay sensor kinase activity
EZV63_RS04360	COG3279	Response regulator of the LytR AlgR family
EZV63_RS04365	COG1522	sequence-specific DNA binding
EZV63_RS04370	COG1834	amidinotransferase
EZV63_RS04375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EZV63_RS04385	COG0477	Major facilitator Superfamily
EZV63_RS04410	COG0740	serine-type endopeptidase activity
EZV63_RS04445	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EZV63_RS04450	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EZV63_RS04455	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EZV63_RS04475	COG0456	acetyltransferase
EZV63_RS04495	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EZV63_RS04520	COG4585	Histidine kinase
EZV63_RS04525	COG2197	response regulator
EZV63_RS04530	COG1940	carbohydrate kinase activity
EZV63_RS04535	COG2188	Transcriptional regulator
EZV63_RS04540	COG1595	DNA-templated transcription, initiation
EZV63_RS04580	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EZV63_RS04585	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EZV63_RS04595	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EZV63_RS04595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EZV63_RS04650	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS04660	COG0419	ATPase involved in DNA repair
EZV63_RS04665	COG0420	3'-5' exonuclease activity
EZV63_RS04690	COG1739	Uncharacterized protein family UPF0029
EZV63_RS04695	COG1832	CoA-binding protein
EZV63_RS04745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EZV63_RS04760	COG1968	undecaprenyl-diphosphatase activity
EZV63_RS04790	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS04795	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EZV63_RS04805	COG2318	DinB family
EZV63_RS04820	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EZV63_RS04860	COG0477	Major facilitator Superfamily
EZV63_RS04875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EZV63_RS04875	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS04875	COG0300	oxidoreductase activity
EZV63_RS04875	COG3321	synthase
EZV63_RS04875	COG0318	PFAM AMP-dependent synthetase and ligase
EZV63_RS04880	COG2175	clavaminate synthase activity
EZV63_RS04885	COG0723	plastoquinol--plastocyanin reductase activity
EZV63_RS04955	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EZV63_RS04965	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EZV63_RS04980	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZV63_RS04985	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EZV63_RS04985	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EZV63_RS04995	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EZV63_RS05015	COG1716	ATPase activity
EZV63_RS05035	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EZV63_RS05065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EZV63_RS05075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EZV63_RS05085	COG2816	NAD+ diphosphatase activity
EZV63_RS05105	COG2018	Roadblock/LC7 domain
EZV63_RS05120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EZV63_RS05125	COG2146	nitrite reductase [NAD(P)H] activity
EZV63_RS05130	COG1414	Transcriptional regulator
EZV63_RS05145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EZV63_RS05185	COG0438	transferase activity, transferring glycosyl groups
EZV63_RS05190	COG0438	transferase activity, transferring glycosyl groups
EZV63_RS05230	COG2270	Major facilitator Superfamily
EZV63_RS05270	COG1960	acyl-CoA dehydrogenase activity
EZV63_RS05320	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EZV63_RS05325	COG0140	phosphoribosyl-ATP diphosphatase activity
EZV63_RS05330	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EZV63_RS05335	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EZV63_RS05335	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EZV63_RS05340	COG3201	nicotinamide mononucleotide transporter
EZV63_RS05350	COG1595	DNA-templated transcription, initiation
EZV63_RS05370	COG2223	nitrite transmembrane transporter activity
EZV63_RS05375	COG2409	Drug exporters of the RND superfamily
EZV63_RS05390	COG2233	PERMEase
EZV63_RS05415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EZV63_RS05445	COG2390	Transcriptional regulator
EZV63_RS05450	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EZV63_RS05455	COG1653	transport
EZV63_RS05490	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EZV63_RS05505	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EZV63_RS05515	COG1758	RNA polymerase activity
EZV63_RS05520	COG0194	GDP metabolic process
EZV63_RS05530	COG0284	orotidine-5'-phosphate decarboxylase activity
EZV63_RS05535	COG0167	dihydroorotate dehydrogenase activity
EZV63_RS05540	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EZV63_RS05545	COG0505	Belongs to the CarA family
EZV63_RS05555	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EZV63_RS05560	COG0540	Belongs to the ATCase OTCase family
EZV63_RS05565	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EZV63_RS05575	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EZV63_RS05580	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EZV63_RS05585	COG0006	proline dipeptidase activity
EZV63_RS05595	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EZV63_RS05600	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EZV63_RS05605	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EZV63_RS05610	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EZV63_RS05620	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EZV63_RS05625	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EZV63_RS05645	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EZV63_RS05660	COG0124	histidyl-tRNA synthetase
EZV63_RS05670	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EZV63_RS05675	COG1196	nuclear chromosome segregation
EZV63_RS05680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EZV63_RS05690	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EZV63_RS05695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EZV63_RS05700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EZV63_RS05710	COG2255	four-way junction helicase activity
EZV63_RS05715	COG0632	four-way junction helicase activity
EZV63_RS05720	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EZV63_RS05725	COG0217	transcriptional regulatory protein
EZV63_RS05730	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EZV63_RS05735	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EZV63_RS05750	COG0438	transferase activity, transferring glycosyl groups
EZV63_RS05755	COG1560	Kdo2-lipid A biosynthetic process
EZV63_RS05760	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EZV63_RS05780	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EZV63_RS05785	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EZV63_RS05805	COG0395	ABC-type sugar transport system, permease component
EZV63_RS05810	COG1175	transmembrane transport
EZV63_RS05865	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EZV63_RS05915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EZV63_RS05920	COG1648	precorrin-2 dehydrogenase activity
EZV63_RS05920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EZV63_RS05925	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EZV63_RS05940	COG1464	Belongs to the NlpA lipoprotein family
EZV63_RS05945	COG2011	ABC-type metal ion transport system permease component
EZV63_RS05950	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EZV63_RS05985	COG0204	Acyl-transferase
EZV63_RS05985	COG0318	PFAM AMP-dependent synthetase and ligase
EZV63_RS05990	COG0477	Major facilitator Superfamily
EZV63_RS06005	COG0165	Argininosuccinate lyase
EZV63_RS06035	COG1438	arginine binding
EZV63_RS06040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EZV63_RS06045	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EZV63_RS06050	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EZV63_RS06055	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EZV63_RS06075	COG0697	spore germination
EZV63_RS06085	COG1649	PFAM Uncharacterised BCR, COG1649
EZV63_RS06115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EZV63_RS06115	COG0072	phenylalanine-tRNA ligase activity
EZV63_RS06120	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EZV63_RS06125	COG5002	protein histidine kinase activity
EZV63_RS06130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EZV63_RS06135	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EZV63_RS06140	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EZV63_RS06145	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EZV63_RS06200	COG0174	glutamine synthetase
EZV63_RS06205	COG2188	Transcriptional regulator
EZV63_RS06210	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EZV63_RS06235	COG4176	ABC-type proline glycine betaine transport system permease component
EZV63_RS06240	COG0517	IMP dehydrogenase activity
EZV63_RS06240	COG4175	Glycine betaine
EZV63_RS06245	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EZV63_RS06260	COG0564	pseudouridine synthase activity
EZV63_RS06295	COG0805	protein transport
EZV63_RS06300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EZV63_RS06330	COG0545	Peptidyl-prolyl cis-trans isomerase
EZV63_RS06335	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
EZV63_RS06345	COG1609	Transcriptional regulator
EZV63_RS06350	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
EZV63_RS06355	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
EZV63_RS06370	COG4122	O-methyltransferase activity
EZV63_RS06375	COG1222	aaa ATPase
EZV63_RS06400	COG0517	IMP dehydrogenase activity
EZV63_RS06400	COG1994	Peptidase M50
EZV63_RS06410	COG2197	response regulator
EZV63_RS06415	COG4166	transmembrane transport
EZV63_RS06425	COG1410	methionine synthase
EZV63_RS06425	COG0646	methionine synthase
EZV63_RS06430	COG1414	Transcriptional regulator
EZV63_RS06435	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EZV63_RS06440	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EZV63_RS06445	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EZV63_RS06455	COG0215	cysteine-tRNA ligase activity
EZV63_RS06470	COG0588	phosphoglycerate mutase activity
EZV63_RS06475	COG0598	Magnesium transport protein CorA
EZV63_RS06485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZV63_RS06490	COG0667	Aldo Keto reductase
EZV63_RS06530	COG3012	SEC-C Motif Domain Protein
EZV63_RS06535	COG2186	Transcriptional regulator
EZV63_RS06540	COG3265	gluconokinase activity
EZV63_RS06550	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS06555	COG1063	alcohol dehydrogenase
EZV63_RS06575	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
EZV63_RS06580	COG2149	membrane
EZV63_RS06605	COG0318	PFAM AMP-dependent synthetase and ligase
EZV63_RS06615	COG3876	Protein conserved in bacteria
EZV63_RS06630	COG0789	Transcriptional regulator
EZV63_RS06650	COG1960	acyl-CoA dehydrogenase activity
EZV63_RS06660	COG0640	Transcriptional regulator
EZV63_RS06685	COG2851	Citrate transporter
EZV63_RS06690	COG0243	molybdopterin cofactor binding
EZV63_RS06695	COG1309	transcriptional regulator
EZV63_RS06705	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EZV63_RS06710	COG2188	Transcriptional regulator
EZV63_RS06740	COG2755	lipolytic protein G-D-S-L family
EZV63_RS06765	COG1725	Transcriptional regulator
EZV63_RS06800	COG0587	DNA-directed DNA polymerase activity
EZV63_RS06825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZV63_RS06845	COG0765	amino acid transport
EZV63_RS06860	COG1799	cell septum assembly
EZV63_RS06865	COG1960	acyl-CoA dehydrogenase activity
EZV63_RS06870	COG0477	Major facilitator Superfamily
EZV63_RS06880	COG0671	phosphoesterase, PA-phosphatase related
EZV63_RS06905	COG1160	GTP binding
EZV63_RS06915	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EZV63_RS06940	COG0494	nUDIX hydrolase
EZV63_RS06945	COG1187	pseudouridine synthase activity
EZV63_RS06950	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EZV63_RS06955	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EZV63_RS06970	COG0686	Belongs to the AlaDH PNT family
EZV63_RS06980	COG0494	nUDIX hydrolase
EZV63_RS06985	COG0504	CTP synthase activity
EZV63_RS06990	COG3387	PFAM Glycoside hydrolase 15-related
EZV63_RS07005	COG0497	DNA recombination
EZV63_RS07010	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EZV63_RS07030	COG1120	ATPase activity
EZV63_RS07035	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZV63_RS07040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZV63_RS07045	COG0647	UMP catabolic process
EZV63_RS07075	COG2094	Belongs to the DNA glycosylase MPG family
EZV63_RS07085	COG1881	PFAM PEBP family protein
EZV63_RS07105	COG1119	ATPase activity
EZV63_RS07120	COG2197	response regulator
EZV63_RS07125	COG4585	Histidine kinase
EZV63_RS07130	COG4221	oxidoreductase activity
EZV63_RS07135	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EZV63_RS07145	COG1131	(ABC) transporter
EZV63_RS07145	COG1716	ATPase activity
EZV63_RS07145	COG0842	Transport permease protein
EZV63_RS07150	COG0560	Phosphoserine phosphatase
EZV63_RS07150	COG3830	Belongs to the UPF0237 family
EZV63_RS07155	COG0588	phosphoglycerate mutase activity
EZV63_RS07165	COG2807	transmembrane transport
EZV63_RS07170	COG2186	Transcriptional regulator
EZV63_RS07180	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS07210	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EZV63_RS07230	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EZV63_RS07235	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EZV63_RS07270	COG3387	PFAM Glycoside hydrolase 15-related
EZV63_RS07275	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS07305	COG1024	Enoyl-CoA hydratase
EZV63_RS07315	COG0488	(ABC) transporter
EZV63_RS07330	COG0235	Class ii aldolase
EZV63_RS07345	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EZV63_RS07350	COG1492	cobalamin metabolic process
EZV63_RS07365	COG1797	cobyrinic acid a,c-diamide synthase activity
EZV63_RS07395	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EZV63_RS07400	COG0456	acetyltransferase
EZV63_RS07405	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EZV63_RS07410	COG1917	Cupin 2, conserved barrel domain protein
EZV63_RS07415	COG5285	phytanoyl-CoA dioxygenase
EZV63_RS07440	COG1414	Transcriptional regulator
EZV63_RS07450	COG0768	penicillin binding
EZV63_RS07460	COG4677	pectinesterase activity
EZV63_RS07465	COG3866	Pectate lyase
EZV63_RS07490	COG0395	ABC-type sugar transport system, permease component
EZV63_RS07495	COG1175	transmembrane transport
EZV63_RS07505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZV63_RS07510	COG1802	Transcriptional regulator
EZV63_RS07515	COG0604	alcohol dehydrogenase
EZV63_RS07530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZV63_RS07535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EZV63_RS07540	COG1349	DNA-binding transcription factor activity
EZV63_RS07560	COG1063	alcohol dehydrogenase
EZV63_RS07570	COG1309	transcriptional regulator
EZV63_RS07590	COG0745	RESPONSE REGULATOR receiver
EZV63_RS07595	COG2205	protein histidine kinase activity
EZV63_RS07630	COG2171	N-acyltransferase activity
EZV63_RS07635	COG3226	Transcriptional regulator
EZV63_RS07640	COG2076	Multidrug Resistance protein
EZV63_RS07645	COG2151	metal-sulfur cluster biosynthetic enzyme
EZV63_RS07650	COG0822	iron-sulfur transferase activity
EZV63_RS07655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EZV63_RS07660	COG0396	ATPase activity
EZV63_RS07670	COG0719	Fe-S assembly protein
EZV63_RS07685	COG2746	aminoglycoside 3-N-acetyltransferase activity
EZV63_RS07690	COG1131	(ABC) transporter
EZV63_RS07700	COG1612	heme a metabolic process
EZV63_RS07720	COG0109	protoheme IX farnesyltransferase activity
EZV63_RS07735	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EZV63_RS07750	COG0363	glucosamine-6-phosphate deaminase activity
EZV63_RS07755	COG0166	Belongs to the GPI family
EZV63_RS07765	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EZV63_RS07770	COG0149	triose-phosphate isomerase activity
EZV63_RS07775	COG0126	phosphoglycerate kinase activity
EZV63_RS07780	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EZV63_RS07785	COG1481	regulation of sporulation
EZV63_RS07790	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EZV63_RS07795	COG1660	Displays ATPase and GTPase activities
EZV63_RS07800	COG0322	excinuclease ABC activity
EZV63_RS07825	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EZV63_RS07840	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EZV63_RS07845	COG0387	Pfam Sodium calcium exchanger
EZV63_RS07865	COG0556	nucleotide-excision repair
EZV63_RS07875	COG0584	glycerophosphoryl diester phosphodiesterase
EZV63_RS07880	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EZV63_RS07890	COG2313	pseudouridylate synthase activity
EZV63_RS07895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EZV63_RS07900	COG2226	methyltransferase
EZV63_RS07945	COG0402	S-adenosylhomocysteine deaminase activity
EZV63_RS07970	COG1309	transcriptional regulator
EZV63_RS08000	COG0667	Aldo Keto reductase
EZV63_RS08010	COG2267	carboxylic ester hydrolase activity
EZV63_RS08025	COG2226	methyltransferase
EZV63_RS08035	COG0237	dephospho-CoA kinase activity
EZV63_RS08050	COG2226	methyltransferase
EZV63_RS08055	COG1643	Atp-dependent helicase
EZV63_RS08085	COG2050	protein possibly involved in aromatic compounds catabolism
EZV63_RS08130	COG0737	Belongs to the 5'-nucleotidase family
EZV63_RS08140	COG0076	glutamate decarboxylase activity
EZV63_RS08150	COG1605	Chorismate mutase
EZV63_RS08150	COG0287	Prephenate dehydrogenase
EZV63_RS08165	COG2304	oxidoreductase activity
EZV63_RS08180	COG0067	glutamate synthase
EZV63_RS08180	COG0070	glutamate synthase
EZV63_RS08180	COG0069	glutamate synthase activity
EZV63_RS08190	COG1397	ADP-ribosylglycohydrolase
EZV63_RS08210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZV63_RS08215	COG2301	Belongs to the HpcH HpaI aldolase family
EZV63_RS08220	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EZV63_RS08230	COG0159	tryptophan synthase activity
EZV63_RS08235	COG0133	tryptophan synthase activity
EZV63_RS08245	COG0134	indole-3-glycerol-phosphate synthase activity
EZV63_RS08270	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EZV63_RS08285	COG0107	imidazoleglycerol-phosphate synthase activity
EZV63_RS08290	COG0251	oxidation-reduction process
EZV63_RS08295	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EZV63_RS08300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EZV63_RS08310	COG0131	Imidazoleglycerol-phosphate dehydratase
EZV63_RS08315	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EZV63_RS08320	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EZV63_RS08340	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EZV63_RS08360	COG1432	Conserved Protein
EZV63_RS08370	COG0587	DNA-directed DNA polymerase activity
EZV63_RS08415	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EZV63_RS08430	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EZV63_RS08435	COG3599	regulation of cell shape
EZV63_RS08445	COG1799	cell septum assembly
EZV63_RS08450	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EZV63_RS08460	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EZV63_RS08465	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EZV63_RS08470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EZV63_RS08480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EZV63_RS08485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EZV63_RS08495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EZV63_RS08500	COG0768	penicillin binding
EZV63_RS08510	COG0275	rRNA processing
EZV63_RS08520	COG0714	Associated with various cellular activities
EZV63_RS08550	COG1309	transcriptional regulator
EZV63_RS08570	COG0352	thiamine-phosphate diphosphorylase activity
EZV63_RS08580	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EZV63_RS08585	COG2022	thiamine diphosphate biosynthetic process
EZV63_RS08585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EZV63_RS08595	COG2022	thiamine diphosphate biosynthetic process
EZV63_RS08600	COG2815	serine threonine protein kinase
EZV63_RS08600	COG0515	serine threonine protein kinase
EZV63_RS08605	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EZV63_RS08610	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EZV63_RS08615	COG2193	ferroxidase activity
EZV63_RS08625	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EZV63_RS08640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EZV63_RS08645	COG0205	6-phosphofructokinase activity
EZV63_RS08650	COG2197	response regulator
EZV63_RS08680	COG1940	carbohydrate kinase activity
EZV63_RS08690	COG0003	Pfam Anion-transporting ATPase
EZV63_RS08710	COG0438	transferase activity, transferring glycosyl groups
EZV63_RS08760	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EZV63_RS08765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EZV63_RS08770	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EZV63_RS08775	COG0723	plastoquinol--plastocyanin reductase activity
EZV63_RS08780	COG2010	Cytochrome c
EZV63_RS08785	COG1845	cytochrome c oxidase, subunit III
EZV63_RS08795	COG1376	ErfK ybiS ycfS ynhG family protein
EZV63_RS08805	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EZV63_RS08810	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EZV63_RS08820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EZV63_RS08855	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EZV63_RS08860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZV63_RS08865	COG2197	response regulator
EZV63_RS08870	COG4585	Histidine kinase
EZV63_RS08890	COG2226	methyltransferase
EZV63_RS08895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EZV63_RS08915	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EZV63_RS08920	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EZV63_RS08930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EZV63_RS08935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EZV63_RS08940	COG0508	dehydrogenase complex catalyzes the overall conversion of
EZV63_RS08950	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EZV63_RS09005	COG0321	lipoyl(octanoyl) transferase activity
EZV63_RS09010	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EZV63_RS09030	COG0174	glutamine synthetase
EZV63_RS09045	COG1733	regulation of RNA biosynthetic process
EZV63_RS09050	COG0501	Belongs to the peptidase M48B family
EZV63_RS09080	COG0745	RESPONSE REGULATOR receiver
EZV63_RS09090	COG2197	response regulator
EZV63_RS09115	COG1309	transcriptional regulator
EZV63_RS09135	COG0366	Alpha amylase catalytic
EZV63_RS09140	COG3833	ABC-type maltose transport systems, permease component
EZV63_RS09145	COG1175	transmembrane transport
EZV63_RS09150	COG1653	transport
EZV63_RS09155	COG1609	Transcriptional regulator
EZV63_RS09165	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EZV63_RS09175	COG2161	toxin-antitoxin pair type II binding
EZV63_RS09180	COG4115	mRNA cleavage
EZV63_RS09190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EZV63_RS09190	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EZV63_RS09205	COG0174	glutamine synthetase
EZV63_RS09215	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EZV63_RS09245	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EZV63_RS09265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EZV63_RS09270	COG2814	Major facilitator Superfamily
EZV63_RS09280	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EZV63_RS09300	COG1994	Peptidase M50
EZV63_RS09355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZV63_RS09360	COG1120	ATPase activity
EZV63_RS09390	COG2197	response regulator
EZV63_RS09400	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EZV63_RS09405	COG2814	Major facilitator Superfamily
EZV63_RS09485	COG2815	serine threonine protein kinase
EZV63_RS09485	COG0515	serine threonine protein kinase
EZV63_RS09490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZV63_RS09500	COG0431	NADPH-dependent FMN reductase
EZV63_RS09515	COG2197	response regulator
EZV63_RS09520	COG4585	Histidine kinase
EZV63_RS09525	COG0586	Pfam SNARE associated Golgi protein
EZV63_RS09550	COG0583	DNA-binding transcription factor activity
EZV63_RS09570	COG1595	DNA-templated transcription, initiation
EZV63_RS09595	COG3629	intracellular signal transduction
EZV63_RS09595	COG3903	Transcriptional regulator
EZV63_RS09615	COG1252	NADH dehydrogenase
EZV63_RS09650	COG3022	response to hydroperoxide
EZV63_RS09655	COG0800	Aldolase
EZV63_RS09670	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EZV63_RS09685	COG2030	dehydratase
EZV63_RS09690	COG4585	Histidine kinase
EZV63_RS09695	COG2197	response regulator
EZV63_RS09705	COG0477	Major facilitator Superfamily
EZV63_RS09740	COG0438	transferase activity, transferring glycosyl groups
EZV63_RS09745	COG1309	transcriptional regulator
EZV63_RS09750	COG1657	PFAM Prenyltransferase squalene oxidase
EZV63_RS09765	COG3845	ABC transporter
EZV63_RS09810	COG2318	DinB family
EZV63_RS09880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EZV63_RS09945	COG0586	Pfam SNARE associated Golgi protein
EZV63_RS09955	COG1358	cellular component organization or biogenesis
EZV63_RS10005	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EZV63_RS10015	COG0477	Major facilitator Superfamily
EZV63_RS10020	COG1309	transcriptional regulator
EZV63_RS10035	COG0789	Transcriptional regulator
EZV63_RS10065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EZV63_RS10070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EZV63_RS10075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EZV63_RS10105	COG1764	response to oxidative stress
EZV63_RS10110	COG2130	NADP-dependent
EZV63_RS10175	COG1129	ABC transporter
EZV63_RS10180	COG4214	carbohydrate transport
EZV63_RS10190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EZV63_RS10195	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EZV63_RS10220	COG0395	ABC-type sugar transport system, permease component
EZV63_RS10225	COG1175	transmembrane transport
EZV63_RS10255	COG3386	PFAM SMP-30 Gluconolaconase
EZV63_RS10260	COG1414	Transcriptional regulator
EZV63_RS10270	COG2186	Transcriptional regulator
EZV63_RS10280	COG0318	PFAM AMP-dependent synthetase and ligase
EZV63_RS10285	COG0825	malonyl-CoA metabolic process
EZV63_RS10285	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EZV63_RS10315	COG1077	Cell shape determining protein MreB Mrl
EZV63_RS10395	COG1674	ftsk spoiiie
EZV63_RS10405	COG0464	growth
EZV63_RS10450	COG1070	Carbohydrate kinase
EZV63_RS10465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EZV63_RS10470	COG0358	DNA primase activity
EZV63_RS10480	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EZV63_RS10490	COG2949	membrane
EZV63_RS10495	COG0243	molybdopterin cofactor binding
EZV63_RS10505	COG0583	DNA-binding transcription factor activity
EZV63_RS10550	COG2146	nitrite reductase [NAD(P)H] activity
EZV63_RS10550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EZV63_RS10570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EZV63_RS10570	COG0574	Belongs to the PEP-utilizing enzyme family
EZV63_RS10610	COG0423	glycine-tRNA ligase activity
EZV63_RS10615	COG0803	Belongs to the bacterial solute-binding protein 9 family
EZV63_RS10615	COG3443	Belongs to the bacterial solute-binding protein 9 family
EZV63_RS10620	COG1120	ATPase activity
EZV63_RS10625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EZV63_RS10635	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EZV63_RS10640	COG1381	Involved in DNA repair and RecF pathway recombination
EZV63_RS10710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EZV63_RS10735	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EZV63_RS10745	COG2315	Protein conserved in bacteria
EZV63_RS10755	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EZV63_RS10760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EZV63_RS10765	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EZV63_RS10770	COG1234	tRNA 3'-trailer cleavage
EZV63_RS10775	COG0537	adenosine 5'-monophosphoramidase activity
EZV63_RS10780	COG4946	Tricorn protease homolog
EZV63_RS10780	COG0793	Belongs to the peptidase S41A family
EZV63_RS10795	COG2070	2-Nitropropane dioxygenase
EZV63_RS10800	COG0484	heat shock protein binding
EZV63_RS10805	COG1420	regulation of RNA biosynthetic process
EZV63_RS10840	COG0481	GTPase activity
EZV63_RS10845	COG0268	Binds directly to 16S ribosomal RNA
EZV63_RS10865	COG2353	YceI-like domain
EZV63_RS10870	COG1234	tRNA 3'-trailer cleavage
EZV63_RS10875	COG1555	photosystem II stabilization
EZV63_RS10880	COG1307	EDD domain protein, DegV family
EZV63_RS10890	COG0495	leucyl-tRNA aminoacylation
EZV63_RS10900	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EZV63_RS10920	COG0588	phosphoglycerate mutase activity
EZV63_RS10925	COG0799	negative regulation of ribosome biogenesis
EZV63_RS10935	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EZV63_RS10950	COG0501	Belongs to the peptidase M48B family
EZV63_RS10965	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EZV63_RS10975	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EZV63_RS10985	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EZV63_RS10990	COG0463	Glycosyl transferase, family 2
EZV63_RS10990	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EZV63_RS10995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EZV63_RS11005	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EZV63_RS11010	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EZV63_RS11015	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EZV63_RS11020	COG1530	ribonuclease E activity
EZV63_RS11045	COG0772	Belongs to the SEDS family
EZV63_RS11065	COG1077	Cell shape determining protein MreB Mrl
EZV63_RS11070	COG0105	UTP biosynthetic process
EZV63_RS11080	COG0285	dihydrofolate synthase activity
EZV63_RS11085	COG0525	valine-tRNA ligase activity
EZV63_RS11095	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EZV63_RS11100	COG0740	serine-type endopeptidase activity
EZV63_RS11105	COG0740	serine-type endopeptidase activity
EZV63_RS11110	COG0544	peptidyl-prolyl cis-trans isomerase activity
EZV63_RS11205	COG3594	Acyltransferase
EZV63_RS11220	COG4552	Acetyltransferase involved in intracellular survival and related
EZV63_RS11235	COG1113	amino acid transport
EZV63_RS11240	COG1268	BioY protein
EZV63_RS11245	COG1113	amino acid transport
EZV63_RS11260	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EZV63_RS11320	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EZV63_RS11340	COG0668	transmembrane transport
EZV63_RS11345	COG1940	carbohydrate kinase activity
EZV63_RS11355	COG1175	transmembrane transport
EZV63_RS11360	COG0395	ABC-type sugar transport system, permease component
EZV63_RS11365	COG1486	melibiose metabolic process
EZV63_RS11380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZV63_RS11390	COG0515	serine threonine protein kinase
EZV63_RS11410	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EZV63_RS11430	COG1136	(ABC) transporter
EZV63_RS11430	COG0577	efflux transmembrane transporter activity
EZV63_RS11455	COG3850	Histidine kinase
EZV63_RS11490	COG0537	adenosine 5'-monophosphoramidase activity
EZV63_RS11500	COG2249	NAD(P)H dehydrogenase (quinone) activity
EZV63_RS11540	COG0629	single-stranded DNA binding
EZV63_RS11565	COG1136	(ABC) transporter
EZV63_RS11575	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EZV63_RS11590	COG2304	oxidoreductase activity
EZV63_RS11620	COG0438	transferase activity, transferring glycosyl groups
EZV63_RS11625	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EZV63_RS11645	COG0438	transferase activity, transferring glycosyl groups
EZV63_RS11690	COG1022	Amp-dependent synthetase and ligase
EZV63_RS11730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EZV63_RS11765	COG1131	(ABC) transporter
EZV63_RS11775	COG1595	DNA-templated transcription, initiation
EZV63_RS11780	COG2072	flavoprotein involved in K transport
EZV63_RS11800	COG0477	Major facilitator Superfamily
EZV63_RS11830	COG1595	DNA-templated transcription, initiation
EZV63_RS11845	COG1129	ABC transporter
EZV63_RS11850	COG1879	ABC-type sugar transport system periplasmic component
EZV63_RS11855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EZV63_RS11860	COG1869	D-ribose catabolic process
EZV63_RS11875	COG0673	inositol 2-dehydrogenase activity
EZV63_RS11900	COG1472	Belongs to the glycosyl hydrolase 3 family
EZV63_RS11970	COG1309	transcriptional regulator
EZV63_RS11980	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EZV63_RS11980	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EZV63_RS11985	COG2356	endonuclease I
EZV63_RS12010	COG1946	Acyl-CoA thioesterase
EZV63_RS12020	COG1309	transcriptional regulator
EZV63_RS12025	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EZV63_RS12040	COG1960	acyl-CoA dehydrogenase activity
EZV63_RS12055	COG3486	L-lysine 6-monooxygenase (NADPH) activity
EZV63_RS12080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EZV63_RS12085	COG0589	response to stress
EZV63_RS12095	COG4977	sequence-specific DNA binding
EZV63_RS12100	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EZV63_RS12120	COG0395	ABC-type sugar transport system, permease component
EZV63_RS12145	COG3979	chitinase
EZV63_RS12155	COG0745	RESPONSE REGULATOR receiver
EZV63_RS12165	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EZV63_RS12235	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EZV63_RS12255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZV63_RS12300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EZV63_RS12315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZV63_RS12320	COG0765	amino acid transport
EZV63_RS12325	COG0765	amino acid transport
EZV63_RS12330	COG1126	abc transporter atp-binding protein
EZV63_RS12345	COG3397	chitin binding
EZV63_RS12395	COG0673	inositol 2-dehydrogenase activity
EZV63_RS12400	COG4702	Belongs to the UPF0303 family
EZV63_RS12425	COG1309	transcriptional regulator
EZV63_RS12430	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS12450	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EZV63_RS12550	COG1063	alcohol dehydrogenase
EZV63_RS12560	COG1902	pentaerythritol trinitrate reductase activity
EZV63_RS12650	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EZV63_RS12675	COG2733	membrane
EZV63_RS12685	COG1940	carbohydrate kinase activity
EZV63_RS12690	COG3119	arylsulfatase activity
EZV63_RS12700	COG4555	ABC transporter
EZV63_RS12715	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EZV63_RS12745	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EZV63_RS12755	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EZV63_RS12760	COG2353	YceI-like domain
EZV63_RS12765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EZV63_RS12770	COG1263	PTS System
EZV63_RS12775	COG1263	PTS System
EZV63_RS12780	COG1234	tRNA 3'-trailer cleavage
EZV63_RS12805	COG1113	amino acid transport
EZV63_RS12815	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EZV63_RS12825	COG1335	isochorismatase
EZV63_RS12845	COG1714	RDD family
EZV63_RS12860	COG0277	FAD linked oxidase domain protein
EZV63_RS12870	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EZV63_RS12880	COG1174	glycine betaine transport
EZV63_RS12890	COG1174	glycine betaine transport
EZV63_RS12900	COG3480	Lon protease (S16) C-terminal proteolytic domain
EZV63_RS12930	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EZV63_RS12945	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EZV63_RS12950	COG0395	ABC-type sugar transport system, permease component
EZV63_RS12955	COG1175	transmembrane transport
EZV63_RS12960	COG1653	transport
EZV63_RS12970	COG1678	Uncharacterized ACR, COG1678
EZV63_RS12975	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EZV63_RS12980	COG0776	regulation of translation
EZV63_RS12990	COG3973	AAA domain
EZV63_RS13015	COG2223	nitrite transmembrane transporter activity
EZV63_RS13055	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EZV63_RS13060	COG0793	Belongs to the peptidase S41A family
EZV63_RS13070	COG2884	Cell division ATP-binding protein ftsE
EZV63_RS13085	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EZV63_RS13090	COG0515	serine threonine protein kinase
EZV63_RS13095	COG0515	serine threonine protein kinase
EZV63_RS13110	COG1175	transmembrane transport
EZV63_RS13115	COG0395	ABC-type sugar transport system, permease component
EZV63_RS13120	COG1216	Glycosyl transferase, family 2
EZV63_RS13125	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EZV63_RS13130	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EZV63_RS13140	COG1764	response to oxidative stress
EZV63_RS13145	COG1846	Transcriptional regulator
EZV63_RS13190	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EZV63_RS13210	COG1134	teichoic acid transport
EZV63_RS13215	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EZV63_RS13220	COG1216	Glycosyl transferase, family 2
EZV63_RS13225	COG2902	Dehydrogenase
EZV63_RS13245	COG0653	protein targeting
EZV63_RS13255	COG3214	Protein conserved in bacteria
EZV63_RS13260	COG2197	response regulator
EZV63_RS13265	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EZV63_RS13275	COG0823	Involved in the tonB-independent uptake of proteins
EZV63_RS13280	COG5000	phosphorelay sensor kinase activity
EZV63_RS13280	COG5002	protein histidine kinase activity
EZV63_RS13285	COG0745	RESPONSE REGULATOR receiver
EZV63_RS13290	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EZV63_RS13310	COG0714	Associated with various cellular activities
EZV63_RS13350	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EZV63_RS13360	COG1482	cell wall glycoprotein biosynthetic process
EZV63_RS13370	COG2835	tetraacyldisaccharide 4'-kinase activity
EZV63_RS13375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EZV63_RS13380	COG1620	l-lactate permease
EZV63_RS13420	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EZV63_RS13425	COG0778	Nitroreductase
EZV63_RS13425	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
EZV63_RS13450	COG1316	TRANSCRIPTIONal
EZV63_RS13455	COG1316	TRANSCRIPTIONal
EZV63_RS13460	COG1316	TRANSCRIPTIONal
EZV63_RS13465	COG1316	TRANSCRIPTIONal
EZV63_RS13470	COG1316	TRANSCRIPTIONal
EZV63_RS13475	COG1316	TRANSCRIPTIONal
EZV63_RS13480	COG1316	TRANSCRIPTIONal
EZV63_RS13500	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EZV63_RS13515	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EZV63_RS13530	COG2205	protein histidine kinase activity
EZV63_RS13535	COG0745	RESPONSE REGULATOR receiver
EZV63_RS13540	COG3104	oligopeptide transport
EZV63_RS13550	COG1366	Belongs to the anti-sigma-factor antagonist family
EZV63_RS13555	COG1191	sigma factor activity
EZV63_RS13560	COG1228	amidohydrolase
EZV63_RS13570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EZV63_RS13605	COG2755	lipolytic protein G-D-S-L family
EZV63_RS13610	COG0183	Belongs to the thiolase family
EZV63_RS13645	COG1136	(ABC) transporter
EZV63_RS13650	COG0577	efflux transmembrane transporter activity
EZV63_RS13655	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EZV63_RS13660	COG1252	NADH dehydrogenase
EZV63_RS13680	COG0148	phosphopyruvate hydratase activity
EZV63_RS13725	COG0577	efflux transmembrane transporter activity
EZV63_RS13725	COG1136	(ABC) transporter
EZV63_RS13730	COG1136	(ABC) transporter
EZV63_RS13760	COG4585	Histidine kinase
EZV63_RS13770	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EZV63_RS13775	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EZV63_RS13780	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EZV63_RS13785	COG0193	aminoacyl-tRNA hydrolase activity
EZV63_RS13800	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EZV63_RS13810	COG1309	transcriptional regulator
EZV63_RS13820	COG4106	trans-aconitate 2-methyltransferase activity
EZV63_RS13830	COG2197	response regulator
EZV63_RS13870	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EZV63_RS13910	COG0488	(ABC) transporter
EZV63_RS13920	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EZV63_RS13925	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EZV63_RS13935	COG0084	hydrolase, TatD family'
EZV63_RS13955	COG0583	DNA-binding transcription factor activity
EZV63_RS13975	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS13990	COG0300	oxidoreductase activity
EZV63_RS14035	COG0310	cobalt ion transport
EZV63_RS14045	COG1122	ATPase activity
EZV63_RS14060	COG0442	prolyl-tRNA aminoacylation
EZV63_RS14075	COG2409	Drug exporters of the RND superfamily
EZV63_RS14085	COG0793	Belongs to the peptidase S41A family
EZV63_RS14085	COG4946	Tricorn protease homolog
EZV63_RS14100	COG2267	carboxylic ester hydrolase activity
EZV63_RS14105	COG2072	flavoprotein involved in K transport
EZV63_RS14115	COG0708	Exodeoxyribonuclease III
EZV63_RS14140	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EZV63_RS14155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EZV63_RS14160	COG0521	Mo-molybdopterin cofactor biosynthetic process
EZV63_RS14160	COG0315	cyclic pyranopterin monophosphate synthase activity
EZV63_RS14165	COG0315	cyclic pyranopterin monophosphate synthase activity
EZV63_RS14175	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EZV63_RS14180	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EZV63_RS14205	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EZV63_RS14215	COG1970	mechanosensitive ion channel activity
EZV63_RS14230	COG3191	aminopeptidase activity
EZV63_RS14240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EZV63_RS14240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EZV63_RS14240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EZV63_RS14250	COG1349	DNA-binding transcription factor activity
EZV63_RS14265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EZV63_RS14270	COG1247	-acetyltransferase
EZV63_RS14275	COG3384	dioxygenase
EZV63_RS14280	COG1846	Transcriptional regulator
EZV63_RS14300	COG1414	Transcriptional regulator
EZV63_RS14310	COG0582	viral genome integration into host DNA
EZV63_RS14420	COG2205	protein histidine kinase activity
EZV63_RS14425	COG0745	RESPONSE REGULATOR receiver
EZV63_RS14430	COG2208	phosphoserine phosphatase activity
EZV63_RS14445	COG0386	Belongs to the glutathione peroxidase family
EZV63_RS14465	COG1686	Belongs to the peptidase S11 family
EZV63_RS14500	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EZV63_RS14520	COG3903	Transcriptional regulator
EZV63_RS14520	COG3629	intracellular signal transduction
EZV63_RS14560	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EZV63_RS14560	COG0515	serine threonine protein kinase
EZV63_RS14575	COG1309	transcriptional regulator
EZV63_RS14585	COG0259	pyridoxamine-phosphate oxidase activity
EZV63_RS14620	COG1366	Belongs to the anti-sigma-factor antagonist family
EZV63_RS14625	COG1595	DNA-templated transcription, initiation
EZV63_RS14665	COG1131	(ABC) transporter
EZV63_RS14675	COG2945	thiolester hydrolase activity
EZV63_RS14675	COG0596	Alpha beta hydrolase
EZV63_RS14685	COG4821	SIS domain
EZV63_RS14700	COG0259	pyridoxamine-phosphate oxidase activity
EZV63_RS14715	COG0318	PFAM AMP-dependent synthetase and ligase
EZV63_RS14730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EZV63_RS14765	COG0604	alcohol dehydrogenase
EZV63_RS14770	COG1309	transcriptional regulator
EZV63_RS14775	COG1733	regulation of RNA biosynthetic process
EZV63_RS14780	COG0604	alcohol dehydrogenase
EZV63_RS14805	COG2318	DinB family
EZV63_RS14810	COG0277	FAD linked oxidase domain protein
EZV63_RS14810	COG0247	lactate metabolic process
EZV63_RS14815	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EZV63_RS14880	COG2197	response regulator
EZV63_RS14910	COG0667	Aldo Keto reductase
EZV63_RS14940	COG2252	PERMEase
EZV63_RS14950	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EZV63_RS14965	COG2814	Major facilitator Superfamily
EZV63_RS14975	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EZV63_RS14980	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
EZV63_RS14985	COG1278	Cold shock
EZV63_RS15010	COG1061	Type III restriction enzyme res subunit
EZV63_RS15020	COG3973	AAA domain
EZV63_RS15055	COG1737	Transcriptional regulator
EZV63_RS15060	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EZV63_RS15070	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS15075	COG1309	transcriptional regulator
EZV63_RS15090	COG0459	protein refolding
EZV63_RS15095	COG1278	Cold shock
EZV63_RS15110	COG0463	Glycosyl transferase, family 2
EZV63_RS15120	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
EZV63_RS15150	COG1105	Belongs to the carbohydrate kinase PfkB family
EZV63_RS15160	COG3300	MHYT domain
EZV63_RS15160	COG5001	Diguanylate cyclase
EZV63_RS15195	COG1064	alcohol dehydrogenase
EZV63_RS15200	COG1309	transcriptional regulator
EZV63_RS15215	COG1215	transferase activity, transferring glycosyl groups
EZV63_RS15220	COG0604	alcohol dehydrogenase
EZV63_RS15230	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS15260	COG3631	Ketosteroid isomerase-related protein
EZV63_RS15265	COG0702	epimerase
EZV63_RS15275	COG2197	response regulator
EZV63_RS15290	COG0464	growth
EZV63_RS15395	COG2890	protein-(glutamine-N5) methyltransferase activity
EZV63_RS15405	COG3842	ATPase activity
EZV63_RS15450	COG0215	cysteine-tRNA ligase activity
EZV63_RS15455	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EZV63_RS15460	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EZV63_RS15465	COG1329	Transcriptional regulator
EZV63_RS15485	COG5002	protein histidine kinase activity
EZV63_RS15510	COG2207	Transcriptional regulator
EZV63_RS15510	COG3708	Transcriptional regulator
EZV63_RS15520	COG3104	oligopeptide transport
EZV63_RS15565	COG0457	Tetratricopeptide repeat
EZV63_RS15595	COG2130	NADP-dependent
EZV63_RS15615	COG2188	Transcriptional regulator
EZV63_RS15645	COG2318	DinB family
EZV63_RS15665	COG2188	Transcriptional regulator
EZV63_RS15700	COG0667	Aldo Keto reductase
EZV63_RS15725	COG2267	carboxylic ester hydrolase activity
EZV63_RS15730	COG0673	inositol 2-dehydrogenase activity
EZV63_RS15740	COG1012	belongs to the aldehyde dehydrogenase family
EZV63_RS15755	COG1733	regulation of RNA biosynthetic process
EZV63_RS15760	COG0588	phosphoglycerate mutase activity
EZV63_RS15785	COG0438	transferase activity, transferring glycosyl groups
EZV63_RS15845	COG0546	phosphoglycolate phosphatase activity
EZV63_RS15850	COG2188	Transcriptional regulator
EZV63_RS15880	COG1490	D-aminoacyl-tRNA deacylase activity
EZV63_RS15885	COG0354	folic acid binding
EZV63_RS15890	COG0735	belongs to the Fur family
EZV63_RS15895	COG3485	protocatechuate 3,4-dioxygenase
EZV63_RS15955	COG2897	thiosulfate sulfurtransferase activity
EZV63_RS15980	COG0745	RESPONSE REGULATOR receiver
EZV63_RS15985	COG1609	Transcriptional regulator
EZV63_RS15990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EZV63_RS15995	COG0745	RESPONSE REGULATOR receiver
EZV63_RS16015	COG0456	acetyltransferase
EZV63_RS16045	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EZV63_RS16075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EZV63_RS16080	COG0306	phosphate transporter
EZV63_RS16090	COG1937	Protein conserved in bacteria
EZV63_RS16110	COG0277	FAD linked oxidase domain protein
EZV63_RS16115	COG0671	phosphoesterase, PA-phosphatase related
EZV63_RS16120	COG1196	nuclear chromosome segregation
EZV63_RS16120	COG0741	lytic transglycosylase activity
EZV63_RS16120	COG0739	heme binding
EZV63_RS16160	COG4585	Histidine kinase
EZV63_RS16165	COG2197	response regulator
EZV63_RS16200	COG1252	NADH dehydrogenase
EZV63_RS16230	COG0579	oxidoreductase
EZV63_RS16235	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EZV63_RS16245	COG0667	Aldo Keto reductase
EZV63_RS16275	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EZV63_RS16275	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EZV63_RS16280	COG1309	transcriptional regulator
EZV63_RS16285	COG0778	Nitroreductase
EZV63_RS16300	COG1414	Transcriptional regulator
EZV63_RS16320	COG2860	membrane
EZV63_RS16325	COG1473	amidohydrolase
EZV63_RS16350	COG0513	Belongs to the DEAD box helicase family
EZV63_RS16385	COG2197	response regulator
EZV63_RS16400	COG0318	PFAM AMP-dependent synthetase and ligase
EZV63_RS16450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZV63_RS16455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZV63_RS16465	COG1131	(ABC) transporter
EZV63_RS16470	COG1643	Atp-dependent helicase
EZV63_RS16495	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EZV63_RS16505	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EZV63_RS16530	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EZV63_RS16535	COG0047	phosphoribosylformylglycinamidine synthase activity
EZV63_RS16540	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EZV63_RS16570	COG3851	Histidine kinase
EZV63_RS16575	COG2197	response regulator
EZV63_RS16585	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EZV63_RS16600	COG0151	Belongs to the GarS family
EZV63_RS16650	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS16700	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EZV63_RS16740	COG1191	sigma factor activity
EZV63_RS16745	COG1191	sigma factor activity
EZV63_RS16765	COG2353	YceI-like domain
EZV63_RS16785	COG3467	pyridoxamine 5'-phosphate
EZV63_RS16795	COG0477	Major facilitator Superfamily
EZV63_RS16805	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EZV63_RS16805	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EZV63_RS16815	COG2205	protein histidine kinase activity
EZV63_RS16820	COG0745	RESPONSE REGULATOR receiver
EZV63_RS16850	COG1733	regulation of RNA biosynthetic process
EZV63_RS16855	COG0768	penicillin binding
EZV63_RS16885	COG0784	Response regulator, receiver
EZV63_RS16890	COG1309	transcriptional regulator
EZV63_RS16895	COG2814	Major facilitator Superfamily
EZV63_RS16900	COG0318	PFAM AMP-dependent synthetase and ligase
EZV63_RS16905	COG1595	DNA-templated transcription, initiation
EZV63_RS16925	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EZV63_RS16935	COG2188	Transcriptional regulator
EZV63_RS16965	COG1674	ftsk spoiiie
EZV63_RS17020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EZV63_RS17035	COG0653	protein targeting
EZV63_RS17055	COG0006	proline dipeptidase activity
EZV63_RS17075	COG1999	signal sequence binding
EZV63_RS17090	COG2837	iron assimilation
EZV63_RS17095	COG0077	Prephenate dehydratase
EZV63_RS17100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EZV63_RS17105	COG0561	phosphatase activity
EZV63_RS17140	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
EZV63_RS17150	COG0561	phosphatase activity
EZV63_RS17155	COG0739	heme binding
EZV63_RS17165	COG4988	ABC transporter
EZV63_RS17170	COG1294	oxidase, subunit
EZV63_RS17175	COG1271	oxidase subunit
EZV63_RS17180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EZV63_RS17185	COG1609	Transcriptional regulator
EZV63_RS17190	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EZV63_RS17205	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EZV63_RS17230	COG0662	Cupin 2, conserved barrel domain protein
EZV63_RS17235	COG1950	PFAM Membrane protein of
EZV63_RS17240	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EZV63_RS17245	COG0626	cystathionine gamma-synthase activity
EZV63_RS17270	COG2814	Major facilitator Superfamily
EZV63_RS17290	COG2197	response regulator
EZV63_RS17295	COG4585	Histidine kinase
EZV63_RS17305	COG0305	Participates in initiation and elongation during chromosome replication
EZV63_RS17315	COG0359	binds to the 23S rRNA
EZV63_RS17320	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EZV63_RS17325	COG0629	single-stranded DNA binding
EZV63_RS17330	COG0360	Binds together with S18 to 16S ribosomal RNA
EZV63_RS17355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EZV63_RS17380	COG0617	tRNA 3'-terminal CCA addition
EZV63_RS17400	COG1595	DNA-templated transcription, initiation
EZV63_RS17410	COG0492	ferredoxin-NADP+ reductase activity
EZV63_RS17415	COG3118	belongs to the thioredoxin family
EZV63_RS17430	COG1192	Involved in chromosome partitioning
EZV63_RS17435	COG0357	Ribosomal RNA small subunit methyltransferase G
EZV63_RS17445	COG0706	membrane insertase activity
EZV63_RS17450	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EZV63_RS17455	COG0594	ribonuclease P activity
EZV63_RS17460	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EZV63_RS17465	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EZV63_RS17470	COG0592	DNA-directed DNA polymerase activity
EZV63_RS17475	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EZV63_RS17480	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EZV63_RS17485	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
EZV63_RS17490	COG0187	DNA topoisomerase II activity
EZV63_RS17495	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EZV63_RS17520	COG2319	Wd-40 repeat
EZV63_RS17520	COG4249	Peptidase C14 caspase catalytic subunit p20
EZV63_RS17545	COG0515	serine threonine protein kinase
EZV63_RS17560	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EZV63_RS17575	COG0705	Rhomboid family
EZV63_RS17600	COG3764	Sortase (surface protein transpeptidase)
EZV63_RS17605	COG3764	Sortase (surface protein transpeptidase)
EZV63_RS17615	COG0515	serine threonine protein kinase
EZV63_RS17620	COG0768	penicillin binding
EZV63_RS17635	COG1716	ATPase activity
EZV63_RS17640	COG1716	ATPase activity
EZV63_RS17685	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZV63_RS17690	COG1309	transcriptional regulator
EZV63_RS17695	COG1522	sequence-specific DNA binding
EZV63_RS17740	COG0604	alcohol dehydrogenase
EZV63_RS17740	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS17740	COG3321	synthase
EZV63_RS17755	COG0515	serine threonine protein kinase
EZV63_RS17760	COG0515	serine threonine protein kinase
EZV63_RS17780	COG0022	dehydrogenase e1 component
EZV63_RS17785	COG0508	dehydrogenase complex catalyzes the overall conversion of
EZV63_RS17830	COG1362	aminopeptidase activity
EZV63_RS17835	COG1960	acyl-CoA dehydrogenase activity
EZV63_RS17845	COG1741	Belongs to the pirin family
EZV63_RS17875	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EZV63_RS17885	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EZV63_RS17935	COG0366	Alpha amylase catalytic
EZV63_RS17955	COG0583	DNA-binding transcription factor activity
EZV63_RS17970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EZV63_RS17995	COG4585	Histidine kinase
EZV63_RS18000	COG2197	response regulator
EZV63_RS18005	COG1136	(ABC) transporter
EZV63_RS18020	COG0596	Alpha beta hydrolase
EZV63_RS18030	COG0577	efflux transmembrane transporter activity
EZV63_RS18030	COG1136	(ABC) transporter
EZV63_RS18090	COG5002	protein histidine kinase activity
EZV63_RS18125	COG0513	Belongs to the DEAD box helicase family
EZV63_RS18130	COG1278	Cold shock
EZV63_RS18135	COG0667	Aldo Keto reductase
EZV63_RS18230	COG1733	regulation of RNA biosynthetic process
EZV63_RS18300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EZV63_RS18305	COG0640	Transcriptional regulator
EZV63_RS18310	COG0798	PFAM Bile acid sodium symporter
EZV63_RS18315	COG2072	flavoprotein involved in K transport
EZV63_RS18320	COG0640	Transcriptional regulator
EZV63_RS18325	COG1234	tRNA 3'-trailer cleavage
EZV63_RS18455	COG0717	Belongs to the dCTP deaminase family
EZV63_RS18460	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EZV63_RS18475	COG2181	nitrate reductase activity
EZV63_RS18475	COG0247	lactate metabolic process
EZV63_RS18480	COG0443	Heat shock 70 kDa protein
EZV63_RS18485	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EZV63_RS18490	COG0484	heat shock protein binding
EZV63_RS18495	COG0789	Transcriptional regulator
EZV63_RS18500	COG4213	ABC transporter substrate-binding protein
EZV63_RS18530	COG0542	response to heat
EZV63_RS18545	COG0596	Alpha beta hydrolase
EZV63_RS18565	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EZV63_RS18580	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EZV63_RS18585	COG0191	fructose-bisphosphate aldolase activity
EZV63_RS18590	COG0477	Major facilitator Superfamily
EZV63_RS18605	COG3844	kynureninase activity
EZV63_RS18625	COG4585	Histidine kinase
EZV63_RS18630	COG2197	response regulator
EZV63_RS18635	COG4585	Histidine kinase
EZV63_RS18640	COG2197	response regulator
EZV63_RS18655	COG3559	Exporter of polyketide antibiotics
EZV63_RS18660	COG1131	(ABC) transporter
EZV63_RS18675	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EZV63_RS18695	COG1802	Transcriptional regulator
EZV63_RS18715	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EZV63_RS18720	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EZV63_RS18730	COG2124	cytochrome p450
EZV63_RS18770	COG1595	DNA-templated transcription, initiation
EZV63_RS18795	COG0640	Transcriptional regulator
EZV63_RS18800	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EZV63_RS18810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EZV63_RS18820	COG1585	Membrane protein implicated in regulation of membrane protease activity
EZV63_RS18825	COG2268	Band 7 protein
EZV63_RS18835	COG3655	Transcriptional regulator
EZV63_RS18845	COG3263	regulation of cellular component size
EZV63_RS18850	COG0475	glutathione-regulated potassium exporter activity
EZV63_RS18905	COG1136	(ABC) transporter
EZV63_RS18945	COG2274	protein secretion by the type I secretion system
EZV63_RS18970	COG1131	(ABC) transporter
EZV63_RS18985	COG4152	abc transporter atp-binding protein
EZV63_RS18990	COG1668	transmembrane transport
EZV63_RS19025	COG1408	metallophosphoesterase
EZV63_RS19035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EZV63_RS19050	COG0003	Pfam Anion-transporting ATPase
EZV63_RS19070	COG0596	Alpha beta hydrolase
EZV63_RS19080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EZV63_RS19095	COG0494	nUDIX hydrolase
EZV63_RS19110	COG0596	Alpha beta hydrolase
EZV63_RS19120	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EZV63_RS19125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EZV63_RS19130	COG0659	secondary active sulfate transmembrane transporter activity
EZV63_RS19190	COG1205	dead DEAH box helicase
EZV63_RS19190	COG1111	helicase
EZV63_RS19195	COG1366	Belongs to the anti-sigma-factor antagonist family
EZV63_RS19200	COG2172	sigma factor antagonist activity
EZV63_RS19205	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EZV63_RS19225	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EZV63_RS19225	COG1754	DNA topoisomerase type I activity
EZV63_RS19230	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EZV63_RS19235	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EZV63_RS19250	COG1487	ribonuclease activity
EZV63_RS19280	COG0300	oxidoreductase activity
EZV63_RS19285	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS19290	COG1959	2 iron, 2 sulfur cluster binding
EZV63_RS19300	COG0667	Aldo Keto reductase
EZV63_RS19305	COG1902	pentaerythritol trinitrate reductase activity
EZV63_RS19320	COG4335	DNA alkylation repair
EZV63_RS19340	COG3268	Saccharopine dehydrogenase
EZV63_RS19360	COG0656	L-ascorbic acid biosynthetic process
EZV63_RS19400	COG0693	protein deglycase activity
EZV63_RS19435	COG2815	serine threonine protein kinase
EZV63_RS19435	COG0515	serine threonine protein kinase
EZV63_RS19440	COG1309	transcriptional regulator
EZV63_RS19450	COG4585	Histidine kinase
EZV63_RS19455	COG2197	response regulator
EZV63_RS19460	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EZV63_RS19460	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EZV63_RS19480	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EZV63_RS19485	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EZV63_RS19490	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EZV63_RS19495	COG0254	rRNA binding
EZV63_RS19505	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EZV63_RS19525	COG1012	belongs to the aldehyde dehydrogenase family
EZV63_RS19565	COG0076	glutamate decarboxylase activity
EZV63_RS19570	COG0789	Transcriptional regulator
EZV63_RS19575	COG0393	Putative heavy-metal-binding
EZV63_RS19580	COG0586	Pfam SNARE associated Golgi protein
EZV63_RS19590	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EZV63_RS19595	COG2027	D-alanyl-D-alanine carboxypeptidase
EZV63_RS19605	COG0037	tRNA processing
EZV63_RS19620	COG0302	gtp cyclohydrolase
EZV63_RS19630	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EZV63_RS19635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EZV63_RS19670	COG0649	NAD binding
EZV63_RS19685	COG2197	response regulator
EZV63_RS19690	COG1660	Displays ATPase and GTPase activities
EZV63_RS19710	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EZV63_RS19725	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EZV63_RS19745	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EZV63_RS19775	COG0739	heme binding
EZV63_RS19815	COG2205	protein histidine kinase activity
EZV63_RS19820	COG0745	RESPONSE REGULATOR receiver
EZV63_RS19830	COG1595	DNA-templated transcription, initiation
EZV63_RS19835	COG1194	a g-specific adenine glycosylase
EZV63_RS19860	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EZV63_RS19880	COG0248	Ppx GppA phosphatase
EZV63_RS19885	COG1082	Xylose isomerase domain protein TIM barrel
EZV63_RS19895	COG0129	dihydroxy-acid dehydratase activity
EZV63_RS19930	COG1129	ABC transporter
EZV63_RS19930	COG0842	Transport permease protein
EZV63_RS19940	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EZV63_RS19945	COG0180	Tryptophanyl-tRNA synthetase
EZV63_RS19965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EZV63_RS19970	COG2223	nitrite transmembrane transporter activity
EZV63_RS19975	COG0123	including yeast histone deacetylase and acetoin utilization protein
EZV63_RS20025	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EZV63_RS20030	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EZV63_RS20035	COG0181	hydroxymethylbilane synthase activity
EZV63_RS20040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EZV63_RS20040	COG1648	precorrin-2 dehydrogenase activity
EZV63_RS20060	COG0113	porphobilinogen synthase activity
EZV63_RS20075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EZV63_RS20095	COG0018	arginyl-trna synthetase
EZV63_RS20100	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
EZV63_RS20120	COG1690	Belongs to the RtcB family
EZV63_RS20130	COG1742	UPF0060 membrane protein
EZV63_RS20135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZV63_RS20140	COG0431	NADPH-dependent FMN reductase
EZV63_RS20145	COG0745	RESPONSE REGULATOR receiver
EZV63_RS20200	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EZV63_RS20255	COG1309	transcriptional regulator
EZV63_RS20260	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS20275	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
EZV63_RS20310	COG1309	transcriptional regulator
EZV63_RS20315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EZV63_RS20325	COG0640	Transcriptional regulator
EZV63_RS20330	COG0798	PFAM Bile acid sodium symporter
EZV63_RS20335	COG0640	Transcriptional regulator
EZV63_RS20375	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EZV63_RS20380	COG0406	alpha-ribazole phosphatase activity
EZV63_RS20390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EZV63_RS20395	COG0785	Cytochrome C biogenesis protein
EZV63_RS20400	COG1333	cytochrome c biogenesis protein
EZV63_RS20405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EZV63_RS20420	COG0515	serine threonine protein kinase
EZV63_RS20420	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EZV63_RS20425	COG0583	DNA-binding transcription factor activity
EZV63_RS20445	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EZV63_RS20450	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EZV63_RS20455	COG0163	prenyltransferase activity
EZV63_RS20465	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EZV63_RS20480	COG1301	dicarboxylic acid transport
EZV63_RS20490	COG1309	transcriptional regulator
EZV63_RS20505	COG0183	Belongs to the thiolase family
EZV63_RS20515	COG2226	methyltransferase
EZV63_RS20525	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
EZV63_RS20535	COG1674	ftsk spoiiie
EZV63_RS20635	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
EZV63_RS20780	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EZV63_RS20810	COG2226	methyltransferase
EZV63_RS20830	COG0242	peptide deformylase activity
EZV63_RS20850	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EZV63_RS20855	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EZV63_RS20860	COG0649	NAD binding
EZV63_RS20870	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EZV63_RS20875	COG1034	ATP synthesis coupled electron transport
EZV63_RS20880	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EZV63_RS20885	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EZV63_RS20895	COG0713	ATP synthesis coupled electron transport
EZV63_RS20900	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EZV63_RS20910	COG1007	ATP synthesis coupled electron transport
EZV63_RS20920	COG0514	ATP-dependent DNA helicase (RecQ)
EZV63_RS20980	COG0561	phosphatase activity
EZV63_RS21000	COG1131	(ABC) transporter
EZV63_RS21010	COG0655	NAD(P)H dehydrogenase (quinone) activity
EZV63_RS21035	COG0702	epimerase
EZV63_RS21040	COG1013	pyruvate-flavodoxin oxidoreductase activity
EZV63_RS21045	COG0674	pyruvate-flavodoxin oxidoreductase activity
EZV63_RS21045	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EZV63_RS21065	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EZV63_RS21070	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EZV63_RS21075	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EZV63_RS21080	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EZV63_RS21085	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EZV63_RS21095	COG0713	ATP synthesis coupled electron transport
EZV63_RS21100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EZV63_RS21110	COG1007	ATP synthesis coupled electron transport
EZV63_RS21115	COG0501	Belongs to the peptidase M48B family
EZV63_RS21120	COG3304	Inner membrane component domain
EZV63_RS21125	COG2261	transglycosylase associated protein
EZV63_RS21130	COG1666	GTP binding
EZV63_RS21175	COG1674	ftsk spoiiie
EZV63_RS21225	COG0702	epimerase
EZV63_RS21230	COG0402	S-adenosylhomocysteine deaminase activity
EZV63_RS21245	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EZV63_RS21250	COG2030	dehydratase
EZV63_RS21265	COG0477	Major facilitator Superfamily
EZV63_RS21275	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EZV63_RS21280	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EZV63_RS21285	COG0436	Aminotransferase
EZV63_RS21295	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EZV63_RS21300	COG0250	Participates in transcription elongation, termination and antitermination
EZV63_RS21305	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EZV63_RS21310	COG0081	regulation of translation
EZV63_RS21325	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EZV63_RS21330	COG0222	ribosome binding
EZV63_RS21335	COG0085	RNA polymerase activity
EZV63_RS21340	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EZV63_RS21355	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EZV63_RS21360	COG0049	tRNA binding
EZV63_RS21365	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EZV63_RS21370	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EZV63_RS21400	COG2267	carboxylic ester hydrolase activity
EZV63_RS21405	COG1309	transcriptional regulator
EZV63_RS21415	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS21425	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EZV63_RS21435	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EZV63_RS21435	COG2755	lipolytic protein G-D-S-L family
EZV63_RS21460	COG0702	epimerase
EZV63_RS21495	COG4104	PAAR repeat-containing protein
EZV63_RS21495	COG3209	COG3209 Rhs family protein
EZV63_RS21505	COG0051	transcription antitermination factor activity, RNA binding
EZV63_RS21510	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EZV63_RS21515	COG0088	Forms part of the polypeptide exit tunnel
EZV63_RS21520	COG0089	rRNA binding
EZV63_RS21525	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EZV63_RS21530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EZV63_RS21535	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EZV63_RS21540	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EZV63_RS21545	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EZV63_RS21550	COG0255	Belongs to the universal ribosomal protein uL29 family
EZV63_RS21555	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EZV63_RS21560	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EZV63_RS21565	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EZV63_RS21570	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EZV63_RS21575	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EZV63_RS21580	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EZV63_RS21585	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EZV63_RS21590	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EZV63_RS21595	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EZV63_RS21600	COG1841	ribosomal large subunit assembly
EZV63_RS21605	COG0200	Binds to the 23S rRNA
EZV63_RS21610	COG0201	protein transport
EZV63_RS21615	COG0563	adenylate kinase activity
EZV63_RS21625	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EZV63_RS21630	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EZV63_RS21635	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EZV63_RS21640	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EZV63_RS21645	COG0202	RNA polymerase activity
EZV63_RS21650	COG0203	ribosomal protein L17
EZV63_RS21655	COG0101	tRNA pseudouridine synthase activity
EZV63_RS21670	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EZV63_RS21675	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EZV63_RS21680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EZV63_RS21690	COG1072	(Pantothenic acid kinase))
EZV63_RS21700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EZV63_RS21740	COG0736	holo-[acyl-carrier-protein] synthase activity
EZV63_RS21745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EZV63_RS21755	COG0802	atpase or kinase
EZV63_RS21780	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EZV63_RS21825	COG4941	Belongs to the sigma-70 factor family
EZV63_RS21835	COG0726	polysaccharide deacetylase
EZV63_RS21840	COG0726	polysaccharide deacetylase
EZV63_RS21845	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EZV63_RS21850	COG0459	protein refolding
EZV63_RS21860	COG4221	oxidoreductase activity
EZV63_RS21870	COG0583	DNA-binding transcription factor activity
EZV63_RS21885	COG1595	DNA-templated transcription, initiation
EZV63_RS21895	COG0516	GMP reductase activity
EZV63_RS21905	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EZV63_RS21915	COG0515	serine threonine protein kinase
EZV63_RS21915	COG2815	serine threonine protein kinase
EZV63_RS21920	COG0515	serine threonine protein kinase
EZV63_RS21925	COG0515	serine threonine protein kinase
EZV63_RS21940	COG1012	belongs to the aldehyde dehydrogenase family
EZV63_RS21955	COG0519	Catalyzes the synthesis of GMP from XMP
EZV63_RS21955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EZV63_RS21995	COG2197	response regulator
EZV63_RS22000	COG0791	NLP P60 protein
EZV63_RS22025	COG0739	heme binding
EZV63_RS22035	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EZV63_RS22035	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EZV63_RS22050	COG0714	Associated with various cellular activities
EZV63_RS22060	COG3552	Protein containing von Willebrand factor type A (VWA) domain
EZV63_RS22075	COG0045	succinate-CoA ligase (ADP-forming) activity
EZV63_RS22105	COG0138	bifunctional purine biosynthesis protein purh
EZV63_RS22125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EZV63_RS22140	COG0039	L-malate dehydrogenase activity
EZV63_RS22145	COG1012	belongs to the aldehyde dehydrogenase family
EZV63_RS22160	COG4176	ABC-type proline glycine betaine transport system permease component
EZV63_RS22170	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EZV63_RS22175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EZV63_RS22185	COG0754	glutathionylspermidine amidase activity
EZV63_RS22190	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EZV63_RS22195	COG0180	Tryptophanyl-tRNA synthetase
EZV63_RS22215	COG0671	phosphoesterase, PA-phosphatase related
EZV63_RS22245	COG1408	metallophosphoesterase
EZV63_RS22250	COG0308	aminopeptidase N
EZV63_RS22255	COG1309	transcriptional regulator
EZV63_RS22285	COG1053	succinate dehydrogenase
EZV63_RS22295	COG2009	succinate dehydrogenase
EZV63_RS22325	COG1595	DNA-templated transcription, initiation
EZV63_RS22340	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EZV63_RS22340	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EZV63_RS22365	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EZV63_RS22390	COG1216	Glycosyl transferase, family 2
EZV63_RS22405	COG2089	acid synthase
EZV63_RS22415	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EZV63_RS22415	COG1473	amidohydrolase
EZV63_RS22420	COG1744	ABC transporter substrate-binding protein PnrA-like
EZV63_RS22470	COG4948	Mandelate Racemase Muconate Lactonizing
EZV63_RS22500	COG2814	Major facilitator Superfamily
EZV63_RS22505	COG0583	DNA-binding transcription factor activity
EZV63_RS22525	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EZV63_RS22540	COG2205	protein histidine kinase activity
EZV63_RS22545	COG0745	RESPONSE REGULATOR receiver
EZV63_RS22550	COG1595	DNA-templated transcription, initiation
EZV63_RS22565	COG0515	serine threonine protein kinase
EZV63_RS22570	COG1012	belongs to the aldehyde dehydrogenase family
EZV63_RS22575	COG1012	belongs to the aldehyde dehydrogenase family
EZV63_RS22590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EZV63_RS22615	COG4770	biotin carboxylase activity
EZV63_RS22625	COG0424	maF-like protein
EZV63_RS22635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EZV63_RS22645	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EZV63_RS22655	COG1024	Enoyl-CoA hydratase
EZV63_RS22665	COG2986	histidine ammonia-lyase
EZV63_RS22685	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EZV63_RS22700	COG1064	alcohol dehydrogenase
EZV63_RS22705	COG0667	Aldo Keto reductase
EZV63_RS22725	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EZV63_RS22745	COG2255	four-way junction helicase activity
EZV63_RS22750	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EZV63_RS22765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EZV63_RS22775	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EZV63_RS22790	COG1331	Highly conserved protein containing a thioredoxin domain
EZV63_RS22805	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
EZV63_RS22815	COG0436	Aminotransferase
EZV63_RS22820	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EZV63_RS22835	COG1414	Transcriptional regulator
EZV63_RS22840	COG0251	oxidation-reduction process
EZV63_RS22845	COG2610	gluconate transmembrane transporter activity
EZV63_RS22905	COG2894	cell division
EZV63_RS22995	COG0789	Transcriptional regulator
EZV63_RS23020	COG2226	methyltransferase
EZV63_RS23025	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EZV63_RS23040	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EZV63_RS23045	COG0450	alkyl hydroperoxide reductase
EZV63_RS23060	COG1136	(ABC) transporter
EZV63_RS23080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EZV63_RS23095	COG0114	fumarate hydratase activity
EZV63_RS23100	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EZV63_RS23100	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EZV63_RS23125	COG0778	Nitroreductase
EZV63_RS23130	COG1722	exodeoxyribonuclease VII activity
EZV63_RS23135	COG1570	exodeoxyribonuclease VII activity
EZV63_RS23145	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EZV63_RS23160	COG0012	GTP binding
EZV63_RS23170	COG1733	regulation of RNA biosynthetic process
EZV63_RS23200	COG2318	DinB family
EZV63_RS23255	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EZV63_RS23290	COG4166	transmembrane transport
EZV63_RS23300	COG0444	Belongs to the ABC transporter superfamily
EZV63_RS23305	COG4608	Belongs to the ABC transporter superfamily
EZV63_RS23310	COG1960	acyl-CoA dehydrogenase activity
EZV63_RS23315	COG2207	Transcriptional regulator
EZV63_RS23325	COG0601	transmembrane transport
EZV63_RS23335	COG0444	Belongs to the ABC transporter superfamily
EZV63_RS23340	COG4608	Belongs to the ABC transporter superfamily
EZV63_RS23360	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
EZV63_RS23370	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EZV63_RS23400	COG0758	DNA mediated transformation
EZV63_RS23425	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EZV63_RS23470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EZV63_RS23480	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EZV63_RS23490	COG0519	Catalyzes the synthesis of GMP from XMP
EZV63_RS23495	COG1024	Enoyl-CoA hydratase
EZV63_RS23510	COG1595	DNA-templated transcription, initiation
EZV63_RS23520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EZV63_RS23525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EZV63_RS23560	COG0598	Magnesium transport protein CorA
EZV63_RS23570	COG2814	Major facilitator Superfamily
EZV63_RS23585	COG2095	MarC family integral membrane protein
EZV63_RS23595	COG1432	Conserved Protein
EZV63_RS23605	COG0513	Belongs to the DEAD box helicase family
EZV63_RS23675	COG0596	Alpha beta hydrolase
EZV63_RS23695	COG0210	DNA helicase
EZV63_RS23700	COG0210	DNA helicase
EZV63_RS23710	COG2816	NAD+ diphosphatase activity
EZV63_RS23740	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EZV63_RS23795	COG3480	Lon protease (S16) C-terminal proteolytic domain
EZV63_RS23805	COG1615	UPF0182 protein
EZV63_RS23830	COG0753	catalase activity
EZV63_RS23840	COG0318	PFAM AMP-dependent synthetase and ligase
EZV63_RS23845	COG1024	Enoyl-CoA hydratase
EZV63_RS23855	COG1024	Enoyl-CoA hydratase
EZV63_RS23860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EZV63_RS23870	COG2271	Major facilitator Superfamily
EZV63_RS23875	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EZV63_RS23885	COG0183	Belongs to the thiolase family
EZV63_RS23890	COG0583	DNA-binding transcription factor activity
EZV63_RS23900	COG0483	inositol monophosphate 1-phosphatase activity
EZV63_RS23910	COG2076	Multidrug Resistance protein
EZV63_RS23915	COG1162	GTPase activity
EZV63_RS23920	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EZV63_RS23930	COG2135	peptidase activity
EZV63_RS23940	COG1595	DNA-templated transcription, initiation
EZV63_RS23945	COG5662	AntiSigma factor
EZV63_RS23965	COG0242	peptide deformylase activity
EZV63_RS23975	COG2124	cytochrome p450
EZV63_RS24015	COG2188	Transcriptional regulator
EZV63_RS24020	COG2182	Extracellular solute-binding protein
EZV63_RS24025	COG1175	transmembrane transport
EZV63_RS24030	COG0395	ABC-type sugar transport system, permease component
EZV63_RS24035	COG1472	Belongs to the glycosyl hydrolase 3 family
EZV63_RS24040	COG0363	glucosamine-6-phosphate deaminase activity
EZV63_RS24055	COG1597	lipid kinase activity
EZV63_RS24085	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EZV63_RS24095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EZV63_RS24115	COG3842	ATPase activity
EZV63_RS24140	COG4106	trans-aconitate 2-methyltransferase activity
EZV63_RS24145	COG1126	abc transporter atp-binding protein
EZV63_RS24160	COG0281	malic enzyme
EZV63_RS24165	COG0604	alcohol dehydrogenase
EZV63_RS24240	COG0508	dehydrogenase complex catalyzes the overall conversion of
EZV63_RS24240	COG0567	Dehydrogenase, E1 component
EZV63_RS24245	COG2205	protein histidine kinase activity
EZV63_RS24250	COG0745	RESPONSE REGULATOR receiver
EZV63_RS24260	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EZV63_RS24305	COG3883	PFAM NLP P60 protein
EZV63_RS24305	COG0791	NLP P60 protein
EZV63_RS24340	COG2205	protein histidine kinase activity
EZV63_RS24360	COG3285	dna ligase
EZV63_RS24360	COG1793	dna ligase
EZV63_RS24365	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
EZV63_RS24380	COG3467	pyridoxamine 5'-phosphate
EZV63_RS24395	COG2867	negative regulation of translational initiation
EZV63_RS24400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EZV63_RS24405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EZV63_RS24410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EZV63_RS24415	COG0662	Cupin 2, conserved barrel domain protein
EZV63_RS24420	COG2329	Antibiotic biosynthesis monooxygenase
EZV63_RS24425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZV63_RS24435	COG2079	MmgE PrpD family protein
EZV63_RS24440	COG1960	acyl-CoA dehydrogenase activity
EZV63_RS24445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZV63_RS24455	COG2186	Transcriptional regulator
EZV63_RS24460	COG2814	Major facilitator Superfamily
EZV63_RS24460	COG0477	Major facilitator Superfamily
EZV63_RS24500	COG0456	acetyltransferase
EZV63_RS24550	COG0210	DNA helicase
EZV63_RS24585	COG0515	serine threonine protein kinase
EZV63_RS24585	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EZV63_RS24600	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EZV63_RS24620	COG0745	RESPONSE REGULATOR receiver
EZV63_RS24625	COG0018	arginyl-trna synthetase
EZV63_RS24630	COG0019	diaminopimelate decarboxylase activity
EZV63_RS24635	COG0460	homoserine dehydrogenase
EZV63_RS24640	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EZV63_RS24645	COG0083	homoserine kinase activity
EZV63_RS24655	COG1316	TRANSCRIPTIONal
EZV63_RS24660	COG0254	rRNA binding
EZV63_RS24665	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EZV63_RS24670	COG2890	protein-(glutamine-N5) methyltransferase activity
EZV63_RS24680	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EZV63_RS24685	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EZV63_RS24690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EZV63_RS24705	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EZV63_RS24710	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EZV63_RS24715	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EZV63_RS24720	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EZV63_RS24725	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EZV63_RS24730	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EZV63_RS24735	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EZV63_RS24750	COG2197	response regulator
EZV63_RS24755	COG4585	Histidine kinase
EZV63_RS24785	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZV63_RS24800	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
EZV63_RS24835	COG1131	(ABC) transporter
EZV63_RS24855	COG0183	Belongs to the thiolase family
EZV63_RS24870	COG0745	RESPONSE REGULATOR receiver
EZV63_RS24920	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EZV63_RS24920	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EZV63_RS24925	COG4977	sequence-specific DNA binding
EZV63_RS24965	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EZV63_RS24970	COG0857	belongs to the CobB CobQ family
EZV63_RS24970	COG0280	phosphate acetyltransferase
EZV63_RS24975	COG0205	6-phosphofructokinase activity
EZV63_RS24985	COG0395	ABC-type sugar transport system, permease component
EZV63_RS24995	COG1653	transport
EZV63_RS25000	COG4565	transcriptional regulatory protein
EZV63_RS25005	COG0745	RESPONSE REGULATOR receiver
EZV63_RS25005	COG4191	Histidine kinase
EZV63_RS25005	COG2205	protein histidine kinase activity
EZV63_RS25010	COG1301	dicarboxylic acid transport
EZV63_RS25030	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EZV63_RS25035	COG3281	Trehalose synthase
EZV63_RS25040	COG0366	Alpha amylase catalytic
EZV63_RS25055	COG0058	SHG alpha-glucan phosphorylase activity
EZV63_RS25075	COG1132	(ABC) transporter
EZV63_RS25080	COG1132	(ABC) transporter
EZV63_RS25100	COG1376	ErfK ybiS ycfS ynhG family protein
EZV63_RS25135	COG0477	Major facilitator Superfamily
EZV63_RS25140	COG2197	response regulator
EZV63_RS25145	COG4585	Histidine kinase
EZV63_RS25155	COG1760	l-serine dehydratase
EZV63_RS25160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EZV63_RS25165	COG0509	glycine decarboxylation via glycine cleavage system
EZV63_RS25170	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EZV63_RS25195	COG4166	transmembrane transport
EZV63_RS25205	COG0444	Belongs to the ABC transporter superfamily
EZV63_RS25210	COG4608	Belongs to the ABC transporter superfamily
EZV63_RS25230	COG0577	efflux transmembrane transporter activity
EZV63_RS25230	COG1136	(ABC) transporter
EZV63_RS25265	COG0789	Transcriptional regulator
EZV63_RS25275	COG1309	transcriptional regulator
EZV63_RS25300	COG0482	sulfurtransferase activity
EZV63_RS25310	COG1611	Belongs to the LOG family
EZV63_RS25315	COG4221	oxidoreductase activity
EZV63_RS25325	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EZV63_RS25335	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EZV63_RS25340	COG0154	amidase activity
EZV63_RS25350	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EZV63_RS25355	COG2409	Drug exporters of the RND superfamily
EZV63_RS25370	COG2197	response regulator
EZV63_RS25385	COG2133	pyrroloquinoline quinone binding
EZV63_RS25390	COG0667	Aldo Keto reductase
EZV63_RS25405	COG5001	Diguanylate cyclase
EZV63_RS25415	COG0440	acetolactate synthase activity
EZV63_RS25420	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EZV63_RS25425	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EZV63_RS25430	COG0477	Major facilitator Superfamily
EZV63_RS25445	COG0506	proline dehydrogenase activity
EZV63_RS25450	COG1012	belongs to the aldehyde dehydrogenase family
EZV63_RS25455	COG0473	3-isopropylmalate dehydrogenase activity
EZV63_RS25460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EZV63_RS25465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EZV63_RS25490	COG5492	domain, Protein
EZV63_RS25495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EZV63_RS25515	COG2018	Roadblock/LC7 domain
EZV63_RS25535	COG2018	Roadblock/LC7 domain
EZV63_RS25540	COG5002	protein histidine kinase activity
EZV63_RS25550	COG0179	Fumarylacetoacetate (FAA) hydrolase
EZV63_RS25555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EZV63_RS25565	COG4977	sequence-specific DNA binding
EZV63_RS25565	COG1917	Cupin 2, conserved barrel domain protein
EZV63_RS25600	COG1414	Transcriptional regulator
EZV63_RS25605	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EZV63_RS25610	COG0066	3-isopropylmalate dehydratase activity
EZV63_RS25620	COG0776	regulation of translation
EZV63_RS25630	COG1920	GTP binding
EZV63_RS25640	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EZV63_RS25645	COG1181	Belongs to the D-alanine--D-alanine ligase family
EZV63_RS25660	COG0351	phosphomethylpyrimidine kinase
EZV63_RS25665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EZV63_RS25670	COG1461	Dihydroxyacetone kinase
EZV63_RS25680	COG0742	ribosomal rna small subunit methyltransferase
EZV63_RS25685	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EZV63_RS25700	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EZV63_RS25705	COG0571	ribonuclease III activity
EZV63_RS25710	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EZV63_RS25715	COG1733	regulation of RNA biosynthetic process
EZV63_RS25725	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS25765	COG2340	Cysteine-rich secretory protein family
EZV63_RS25770	COG1254	Belongs to the acylphosphatase family
EZV63_RS25780	COG1196	nuclear chromosome segregation
EZV63_RS25785	COG0477	Major facilitator Superfamily
EZV63_RS25790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EZV63_RS25800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EZV63_RS25815	COG0596	Alpha beta hydrolase
EZV63_RS25820	COG0318	PFAM AMP-dependent synthetase and ligase
EZV63_RS25825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EZV63_RS25835	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EZV63_RS25870	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EZV63_RS25895	COG0228	four-way junction DNA binding
EZV63_RS25900	COG1837	Belongs to the UPF0109 family
EZV63_RS25905	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EZV63_RS25910	COG0336	Belongs to the RNA methyltransferase TrmD family
EZV63_RS25915	COG0335	large ribosomal subunit rRNA binding
EZV63_RS25920	COG0681	Belongs to the peptidase S26 family
EZV63_RS25930	COG0681	Belongs to the peptidase S26 family
EZV63_RS25950	COG0792	nuclease activity
EZV63_RS25965	COG1191	sigma factor activity
EZV63_RS25980	COG0052	Belongs to the universal ribosomal protein uS2 family
EZV63_RS25985	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EZV63_RS25990	COG0528	UMP kinase activity
EZV63_RS25995	COG0233	cytoplasmic translational termination
EZV63_RS26000	COG0575	Belongs to the CDS family
EZV63_RS26005	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EZV63_RS26015	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EZV63_RS26020	COG3842	ATPase activity
EZV63_RS26050	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EZV63_RS26060	COG1012	belongs to the aldehyde dehydrogenase family
EZV63_RS26070	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EZV63_RS26100	COG3842	ATPase activity
EZV63_RS26105	COG1176	ABC-type spermidine putrescine transport system, permease component I
EZV63_RS26110	COG1177	transmembrane transport
EZV63_RS26115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EZV63_RS26145	COG2508	Transcriptional regulator
EZV63_RS26150	COG1012	belongs to the aldehyde dehydrogenase family
EZV63_RS26170	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EZV63_RS26175	COG0750	zinc metalloprotease
EZV63_RS26180	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EZV63_RS26195	COG0442	prolyl-tRNA aminoacylation
EZV63_RS26215	COG0779	Required for maturation of 30S ribosomal subunits
EZV63_RS26230	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EZV63_RS26240	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EZV63_RS26245	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EZV63_RS26260	COG4608	Belongs to the ABC transporter superfamily
EZV63_RS26270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EZV63_RS26275	COG0601	transmembrane transport
EZV63_RS26280	COG0747	negative chemotaxis
EZV63_RS26285	COG0455	bacterial-type flagellum organization
EZV63_RS26295	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EZV63_RS26300	COG1185	polyribonucleotide nucleotidyltransferase activity
EZV63_RS26305	COG0612	Peptidase, M16
EZV63_RS26310	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EZV63_RS26330	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
EZV63_RS26335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZV63_RS26340	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EZV63_RS26370	COG2208	phosphoserine phosphatase activity
EZV63_RS26370	COG2770	Histidine kinase
EZV63_RS26380	COG0784	Response regulator, receiver
EZV63_RS26380	COG2205	protein histidine kinase activity
EZV63_RS26390	COG1674	ftsk spoiiie
EZV63_RS26400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EZV63_RS26410	COG1546	Belongs to the CinA family
EZV63_RS26410	COG1058	Belongs to the CinA family
EZV63_RS26415	COG1396	sequence-specific DNA binding
EZV63_RS26430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EZV63_RS26435	COG1201	RNA secondary structure unwinding
EZV63_RS26440	COG1917	Cupin 2, conserved barrel domain protein
EZV63_RS26440	COG2207	Transcriptional regulator
EZV63_RS26465	COG0628	permease
EZV63_RS26480	COG0246	Mannitol dehydrogenase
EZV63_RS26485	COG0477	Major facilitator Superfamily
EZV63_RS26490	COG1063	alcohol dehydrogenase
EZV63_RS26500	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EZV63_RS26510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EZV63_RS26525	COG0765	amino acid transport
EZV63_RS26530	COG0765	amino acid transport
EZV63_RS26535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZV63_RS26540	COG1126	abc transporter atp-binding protein
EZV63_RS26545	COG0745	RESPONSE REGULATOR receiver
EZV63_RS26550	COG2205	protein histidine kinase activity
EZV63_RS26570	COG3851	Histidine kinase
EZV63_RS26575	COG2197	response regulator
EZV63_RS26580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EZV63_RS26600	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EZV63_RS26610	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EZV63_RS26615	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EZV63_RS26625	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EZV63_RS26660	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EZV63_RS26665	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EZV63_RS26670	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EZV63_RS26685	COG0588	phosphoglycerate mutase activity
EZV63_RS26705	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EZV63_RS26740	COG2186	Transcriptional regulator
EZV63_RS26745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EZV63_RS26760	COG0187	DNA topoisomerase II activity
EZV63_RS26775	COG2197	response regulator
EZV63_RS26785	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EZV63_RS26790	COG4565	transcriptional regulatory protein
EZV63_RS26795	COG3290	protein histidine kinase activity
EZV63_RS26810	COG2249	NAD(P)H dehydrogenase (quinone) activity
EZV63_RS26815	COG0583	DNA-binding transcription factor activity
EZV63_RS26835	COG0456	acetyltransferase
EZV63_RS26835	COG0454	-acetyltransferase
EZV63_RS26840	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS26895	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EZV63_RS26900	COG0612	Peptidase, M16
EZV63_RS26915	COG1802	Transcriptional regulator
EZV63_RS26920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EZV63_RS26945	COG1435	thymidine kinase activity
EZV63_RS26995	COG0745	RESPONSE REGULATOR receiver
EZV63_RS27000	COG2205	protein histidine kinase activity
EZV63_RS27025	COG0756	dUTP diphosphatase activity
EZV63_RS27065	COG0569	domain protein
EZV63_RS27075	COG0531	amino acid
EZV63_RS27080	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EZV63_RS27090	COG3654	unkown
EZV63_RS27095	COG0586	Pfam SNARE associated Golgi protein
EZV63_RS27100	COG4585	Histidine kinase
EZV63_RS27110	COG2423	ornithine cyclodeaminase activity
EZV63_RS27135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EZV63_RS27145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EZV63_RS27165	COG0318	PFAM AMP-dependent synthetase and ligase
EZV63_RS27210	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EZV63_RS27240	COG2197	response regulator
EZV63_RS27280	COG2814	Major facilitator Superfamily
EZV63_RS27345	COG4948	Mandelate Racemase Muconate Lactonizing
EZV63_RS27350	COG0395	ABC-type sugar transport system, permease component
EZV63_RS27355	COG1175	transmembrane transport
EZV63_RS27365	COG2188	Transcriptional regulator
EZV63_RS27370	COG0477	Major facilitator Superfamily
EZV63_RS27395	COG1609	Transcriptional regulator
EZV63_RS27415	COG1175	transmembrane transport
EZV63_RS27420	COG0395	ABC-type sugar transport system, permease component
EZV63_RS27450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EZV63_RS27465	COG1063	alcohol dehydrogenase
EZV63_RS27520	COG0662	Cupin 2, conserved barrel domain protein
EZV63_RS27530	COG0583	DNA-binding transcription factor activity
EZV63_RS27565	COG2197	response regulator
EZV63_RS27570	COG4585	Histidine kinase
EZV63_RS27575	COG2409	Drug exporters of the RND superfamily
EZV63_RS27580	COG0531	amino acid
EZV63_RS27590	COG0477	Major facilitator Superfamily
EZV63_RS27595	COG1122	ATPase activity
EZV63_RS27605	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
EZV63_RS27610	COG0310	cobalt ion transport
EZV63_RS27615	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EZV63_RS27630	COG1799	cell septum assembly
EZV63_RS27655	COG0475	glutathione-regulated potassium exporter activity
EZV63_RS27660	COG2235	arginine
EZV63_RS27665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EZV63_RS27670	COG0531	amino acid
EZV63_RS27680	COG1024	Enoyl-CoA hydratase
EZV63_RS27760	COG2124	cytochrome p450
EZV63_RS27770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZV63_RS27795	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EZV63_RS27800	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EZV63_RS27810	COG1414	Transcriptional regulator
EZV63_RS27815	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EZV63_RS27825	COG2130	NADP-dependent
EZV63_RS27830	COG1233	COG1233 Phytoene dehydrogenase and related
EZV63_RS27875	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EZV63_RS27885	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EZV63_RS27910	COG1653	transport
EZV63_RS27915	COG1175	transmembrane transport
EZV63_RS27920	COG0395	ABC-type sugar transport system, permease component
EZV63_RS27925	COG1940	carbohydrate kinase activity
EZV63_RS27930	COG4213	ABC transporter substrate-binding protein
EZV63_RS27940	COG4214	carbohydrate transport
EZV63_RS27945	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EZV63_RS27950	COG0531	amino acid
EZV63_RS27965	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZV63_RS27965	COG1024	Enoyl-CoA hydratase
EZV63_RS27970	COG0183	Belongs to the thiolase family
EZV63_RS27975	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EZV63_RS27990	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EZV63_RS27995	COG1472	Belongs to the glycosyl hydrolase 3 family
EZV63_RS28070	COG0446	pyridine nucleotide-disulphide oxidoreductase
EZV63_RS28095	COG3220	belongs to the UPF0276 family
EZV63_RS28105	COG3842	ATPase activity
EZV63_RS28120	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS28120	COG0604	alcohol dehydrogenase
EZV63_RS28120	COG3321	synthase
EZV63_RS28125	COG1733	regulation of RNA biosynthetic process
EZV63_RS28130	COG0726	polysaccharide deacetylase
EZV63_RS28135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EZV63_RS28135	COG0723	plastoquinol--plastocyanin reductase activity
EZV63_RS28145	COG0659	secondary active sulfate transmembrane transporter activity
EZV63_RS28175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EZV63_RS28180	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EZV63_RS28200	COG3629	intracellular signal transduction
EZV63_RS28200	COG3903	Transcriptional regulator
EZV63_RS28215	COG3629	intracellular signal transduction
EZV63_RS28215	COG3903	Transcriptional regulator
EZV63_RS28220	COG2205	protein histidine kinase activity
EZV63_RS28225	COG0745	RESPONSE REGULATOR receiver
EZV63_RS28250	COG1174	glycine betaine transport
EZV63_RS28255	COG1174	glycine betaine transport
EZV63_RS28260	COG1732	Glycine betaine
EZV63_RS28305	COG1309	transcriptional regulator
EZV63_RS28330	COG3173	Aminoglycoside phosphotransferase
EZV63_RS28380	COG1175	transmembrane transport
EZV63_RS28395	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EZV63_RS28415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZV63_RS28420	COG1116	anion transmembrane transporter activity
EZV63_RS28445	COG0529	Catalyzes the synthesis of activated sulfate
EZV63_RS28450	COG0175	sulfate reduction
EZV63_RS28480	COG1960	acyl-CoA dehydrogenase activity
EZV63_RS28490	COG1846	Transcriptional regulator
EZV63_RS28490	COG1940	carbohydrate kinase activity
EZV63_RS28515	COG1846	Transcriptional regulator
EZV63_RS28515	COG1940	carbohydrate kinase activity
EZV63_RS28575	COG2027	D-alanyl-D-alanine carboxypeptidase
EZV63_RS28590	COG0714	Associated with various cellular activities
EZV63_RS28605	COG2040	homocysteine
EZV63_RS28620	COG2197	response regulator
EZV63_RS28630	COG0277	FAD linked oxidase domain protein
EZV63_RS28645	COG1162	GTPase activity
EZV63_RS28650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EZV63_RS28670	COG0028	Belongs to the TPP enzyme family
EZV63_RS28695	COG1802	Transcriptional regulator
EZV63_RS28700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EZV63_RS28710	COG2197	response regulator
EZV63_RS28745	COG3835	regulator
EZV63_RS28760	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EZV63_RS28765	COG2252	PERMEase
EZV63_RS28785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EZV63_RS28790	COG2192	nodulation
EZV63_RS28800	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EZV63_RS28805	COG0859	PFAM glycosyl transferase family 9
EZV63_RS28810	COG0438	transferase activity, transferring glycosyl groups
EZV63_RS28815	COG0438	transferase activity, transferring glycosyl groups
EZV63_RS28820	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EZV63_RS28825	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EZV63_RS28825	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EZV63_RS28860	COG2319	Wd-40 repeat
EZV63_RS28860	COG4249	Peptidase C14 caspase catalytic subunit p20
EZV63_RS28900	COG1295	ribonuclease BN
EZV63_RS28915	COG2197	response regulator
EZV63_RS28920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EZV63_RS28925	COG0318	PFAM AMP-dependent synthetase and ligase
EZV63_RS28960	COG3960	tartronate-semialdehyde synthase activity
EZV63_RS28975	COG0753	catalase activity
EZV63_RS28980	COG2084	Dehydrogenase
EZV63_RS28985	COG3622	Belongs to the hyi family
EZV63_RS29005	COG2351	hydroxyisourate hydrolase activity
EZV63_RS29020	COG2233	PERMEase
EZV63_RS29030	COG0406	alpha-ribazole phosphatase activity
EZV63_RS29035	COG0436	Aminotransferase
EZV63_RS29055	COG4264	IucA IucC family
EZV63_RS29080	COG1285	pathogenesis
EZV63_RS29090	COG3046	protein related to deoxyribodipyrimidine photolyase
EZV63_RS29115	COG1414	Transcriptional regulator
EZV63_RS29120	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EZV63_RS29125	COG4266	Belongs to the allantoicase family
EZV63_RS29130	COG2066	Belongs to the glutaminase family
EZV63_RS29145	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EZV63_RS29160	COG1335	isochorismatase
EZV63_RS29170	COG2188	Transcriptional regulator
EZV63_RS29190	COG1940	carbohydrate kinase activity
EZV63_RS29200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EZV63_RS29210	COG2197	response regulator
EZV63_RS29240	COG0444	Belongs to the ABC transporter superfamily
EZV63_RS29265	COG0523	cobalamin synthesis protein
EZV63_RS29340	COG3433	isochorismatase activity
EZV63_RS29340	COG1535	isochorismatase
EZV63_RS29345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EZV63_RS29355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZV63_RS29360	COG1120	ATPase activity
EZV63_RS29365	COG0596	Alpha beta hydrolase
EZV63_RS29380	COG1733	regulation of RNA biosynthetic process
EZV63_RS29405	COG1414	Transcriptional regulator
EZV63_RS29410	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EZV63_RS29415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EZV63_RS29420	COG1414	Transcriptional regulator
EZV63_RS29425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZV63_RS29435	COG1309	transcriptional regulator
EZV63_RS29465	COG3415	Transposase
EZV63_RS29465	COG2801	Transposase and inactivated derivatives
EZV63_RS29540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EZV63_RS29565	COG1024	Enoyl-CoA hydratase
EZV63_RS29570	COG0318	PFAM AMP-dependent synthetase and ligase
EZV63_RS29590	COG0659	secondary active sulfate transmembrane transporter activity
EZV63_RS29605	COG3547	Transposase (IS116 IS110 IS902 family)
EZV63_RS29620	COG4106	trans-aconitate 2-methyltransferase activity
EZV63_RS29630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EZV63_RS29645	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EZV63_RS29650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZV63_RS29655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EZV63_RS29660	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EZV63_RS29670	COG1181	Belongs to the D-alanine--D-alanine ligase family
EZV63_RS29675	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EZV63_RS29700	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EZV63_RS29705	COG0577	efflux transmembrane transporter activity
EZV63_RS29705	COG1136	(ABC) transporter
EZV63_RS29710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EZV63_RS29720	COG0318	PFAM AMP-dependent synthetase and ligase
EZV63_RS29725	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZV63_RS29800	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EZV63_RS29820	COG0673	inositol 2-dehydrogenase activity
EZV63_RS29835	COG0577	efflux transmembrane transporter activity
EZV63_RS29835	COG1136	(ABC) transporter
EZV63_RS29915	COG0515	serine threonine protein kinase
EZV63_RS29960	COG2267	carboxylic ester hydrolase activity
EZV63_RS30010	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
EZV63_RS30025	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EZV63_RS30095	COG3387	PFAM Glycoside hydrolase 15-related
EZV63_RS30150	COG0405	Gamma-glutamyltransferase
EZV63_RS30170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EZV63_RS30180	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EZV63_RS30185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZV63_RS30190	COG1953	Uracil, thiamine, allantoin
EZV63_RS30235	COG0765	amino acid transport
EZV63_RS30265	COG2207	Transcriptional regulator
EZV63_RS30265	COG0662	Cupin 2, conserved barrel domain protein
EZV63_RS30275	COG0483	inositol monophosphate 1-phosphatase activity
EZV63_RS30285	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
EZV63_RS30320	COG0477	Major facilitator Superfamily
EZV63_RS30330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZV63_RS30340	COG0583	DNA-binding transcription factor activity
EZV63_RS30345	COG2610	gluconate transmembrane transporter activity
EZV63_RS30355	COG3540	Alkaline phosphatase
EZV63_RS30365	COG0640	Transcriptional regulator
EZV63_RS30380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EZV63_RS30390	COG1929	Belongs to the glycerate kinase type-1 family
EZV63_RS30400	COG0688	phosphatidylethanolamine metabolic process
EZV63_RS30405	COG1960	acyl-CoA dehydrogenase activity
EZV63_RS30415	COG2301	Belongs to the HpcH HpaI aldolase family
EZV63_RS30420	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EZV63_RS30420	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EZV63_RS30435	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZV63_RS30485	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EZV63_RS30490	COG2362	D-Aminopeptidase
EZV63_RS30495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EZV63_RS30500	COG0823	Involved in the tonB-independent uptake of proteins
EZV63_RS30500	COG4946	Tricorn protease homolog
EZV63_RS30500	COG1506	peptidase
EZV63_RS30505	COG1619	proteins homologs of microcin C7 resistance protein MccF
EZV63_RS30530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZV63_RS30545	COG3285	dna ligase
EZV63_RS30545	COG1793	dna ligase
EZV63_RS30600	COG2226	methyltransferase
EZV63_RS30605	COG1597	lipid kinase activity
EZV63_RS30635	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EZV63_RS30715	COG2154	pterin-4-alpha-carbinolamine dehydratase
EZV63_RS30720	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EZV63_RS30720	COG4106	trans-aconitate 2-methyltransferase activity
EZV63_RS30725	COG5297	Belongs to the glycosyl hydrolase family 6
EZV63_RS30730	COG2226	methyltransferase
EZV63_RS30735	COG0656	L-ascorbic acid biosynthetic process
EZV63_RS30770	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EZV63_RS30780	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EZV63_RS30785	COG3383	formate dehydrogenase (NAD+) activity
EZV63_RS30790	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EZV63_RS30805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EZV63_RS30820	COG1129	ABC transporter
EZV63_RS30825	COG1172	Belongs to the binding-protein-dependent transport system permease family
EZV63_RS30835	COG0673	inositol 2-dehydrogenase activity
EZV63_RS30855	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EZV63_RS30930	COG2182	Extracellular solute-binding protein
EZV63_RS30935	COG1175	transmembrane transport
EZV63_RS30940	COG0395	ABC-type sugar transport system, permease component
EZV63_RS30945	COG2723	6-phospho-beta-galactosidase activity
EZV63_RS30970	COG1733	regulation of RNA biosynthetic process
EZV63_RS30995	COG0300	oxidoreductase activity
EZV63_RS31010	COG0765	amino acid transport
EZV63_RS31035	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS31050	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EZV63_RS31095	COG0300	oxidoreductase activity
EZV63_RS31120	COG0297	glycogen (starch) synthase activity
EZV63_RS31135	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EZV63_RS31145	COG0477	Major facilitator Superfamily
EZV63_RS31155	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EZV63_RS31170	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EZV63_RS31175	COG0166	Belongs to the GPI family
EZV63_RS31190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EZV63_RS31210	COG1486	melibiose metabolic process
EZV63_RS31260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZV63_RS31265	COG3938	Belongs to the proline racemase family
EZV63_RS31290	COG0667	Aldo Keto reductase
EZV63_RS31295	COG3511	phospholipase C
EZV63_RS31325	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EZV63_RS31330	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EZV63_RS31335	COG3485	protocatechuate 3,4-dioxygenase
EZV63_RS31340	COG3485	protocatechuate 3,4-dioxygenase
EZV63_RS31350	COG1470	cell adhesion involved in biofilm formation
EZV63_RS31360	COG1793	dna ligase
EZV63_RS31390	COG0656	L-ascorbic acid biosynthetic process
EZV63_RS31410	COG1834	amidinotransferase
EZV63_RS31415	COG0488	(ABC) transporter
EZV63_RS31435	COG1515	deoxyribonuclease V activity
EZV63_RS31450	COG3268	Saccharopine dehydrogenase
EZV63_RS31455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZV63_RS31460	COG0183	Belongs to the thiolase family
EZV63_RS31465	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZV63_RS31465	COG1024	Enoyl-CoA hydratase
EZV63_RS31470	COG0789	Transcriptional regulator
EZV63_RS31475	COG1113	amino acid transport
EZV63_RS31500	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EZV63_RS31510	COG0488	(ABC) transporter
EZV63_RS31515	COG2183	response to ionizing radiation
EZV63_RS31535	COG1024	Enoyl-CoA hydratase
EZV63_RS31545	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
EZV63_RS31585	COG1134	teichoic acid transport
EZV63_RS31590	COG1562	ergosterol biosynthetic process
EZV63_RS31600	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EZV63_RS31610	COG1657	PFAM Prenyltransferase squalene oxidase
EZV63_RS31625	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EZV63_RS31630	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EZV63_RS31690	COG1408	metallophosphoesterase
EZV63_RS31710	COG0601	transmembrane transport
EZV63_RS31725	COG1021	2,3-dihydroxybenzoate-AMP ligase
EZV63_RS31730	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
EZV63_RS31730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EZV63_RS31735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EZV63_RS31735	COG2226	methyltransferase
EZV63_RS31735	COG3433	isochorismatase activity
EZV63_RS31775	COG1169	isochorismate synthase
EZV63_RS31785	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EZV63_RS31790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EZV63_RS31825	COG1063	alcohol dehydrogenase
EZV63_RS31830	COG0156	8-amino-7-oxononanoate synthase activity
EZV63_RS31835	COG0583	DNA-binding transcription factor activity
EZV63_RS31860	COG0604	alcohol dehydrogenase
EZV63_RS31865	COG2111	Na H antiporter
EZV63_RS31865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EZV63_RS31935	COG2267	carboxylic ester hydrolase activity
EZV63_RS31940	COG0183	Belongs to the thiolase family
EZV63_RS31945	COG0318	PFAM AMP-dependent synthetase and ligase
EZV63_RS31970	COG0745	RESPONSE REGULATOR receiver
EZV63_RS31975	COG2205	protein histidine kinase activity
EZV63_RS31980	COG2986	histidine ammonia-lyase
EZV63_RS31985	COG0492	ferredoxin-NADP+ reductase activity
EZV63_RS32000	COG0475	glutathione-regulated potassium exporter activity
EZV63_RS32005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZV63_RS32035	COG2188	Transcriptional regulator
EZV63_RS32040	COG3962	Belongs to the TPP enzyme family
EZV63_RS32045	COG3718	enzyme involved in inositol metabolism
EZV63_RS32055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EZV63_RS32085	COG0673	inositol 2-dehydrogenase activity
EZV63_RS32090	COG0673	inositol 2-dehydrogenase activity
EZV63_RS32095	COG2186	Transcriptional regulator
EZV63_RS32100	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EZV63_RS32105	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EZV63_RS32120	COG2814	Major facilitator Superfamily
EZV63_RS32125	COG0385	Bile acid
EZV63_RS32135	COG1063	alcohol dehydrogenase
EZV63_RS32145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZV63_RS32150	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EZV63_RS32165	COG0546	phosphoglycolate phosphatase activity
EZV63_RS32200	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EZV63_RS32240	COG0778	Nitroreductase
EZV63_RS32260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZV63_RS32265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZV63_RS32270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZV63_RS32280	COG2197	response regulator
EZV63_RS32290	COG1404	Belongs to the peptidase S8 family
EZV63_RS32305	COG2124	cytochrome p450
EZV63_RS32315	COG2838	Isocitrate dehydrogenase
EZV63_RS32320	COG0668	transmembrane transport
EZV63_RS32335	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EZV63_RS32355	COG1132	(ABC) transporter
EZV63_RS32360	COG0366	Alpha amylase catalytic
EZV63_RS32365	COG0395	ABC-type sugar transport system, permease component
EZV63_RS32370	COG1175	transmembrane transport
EZV63_RS32375	COG1653	transport
EZV63_RS32410	COG1461	Dihydroxyacetone kinase
EZV63_RS32415	COG2376	Dihydroxyacetone kinase
EZV63_RS32420	COG0477	Major facilitator Superfamily
EZV63_RS32425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZV63_RS32445	COG2031	fatty acid transporter
EZV63_RS32450	COG2423	ornithine cyclodeaminase activity
EZV63_RS32455	COG1017	nitric oxide dioxygenase activity
EZV63_RS32455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EZV63_RS32460	COG1802	Transcriptional regulator
EZV63_RS32525	COG3550	peptidyl-serine autophosphorylation
EZV63_RS32535	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EZV63_RS32545	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EZV63_RS32550	COG1309	transcriptional regulator
EZV63_RS32555	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS32575	COG0297	glycogen (starch) synthase activity
EZV63_RS32580	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EZV63_RS32585	COG3537	Alpha-1,2-mannosidase
EZV63_RS32615	COG0154	amidase activity
EZV63_RS32620	COG1609	Transcriptional regulator
EZV63_RS32630	COG1175	transmembrane transport
EZV63_RS32635	COG0395	ABC-type sugar transport system, permease component
EZV63_RS32660	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EZV63_RS32680	COG2843	Capsule synthesis protein
EZV63_RS32695	COG0531	amino acid
EZV63_RS32705	COG0726	polysaccharide deacetylase
EZV63_RS32750	COG0583	DNA-binding transcription factor activity
EZV63_RS32760	COG0583	DNA-binding transcription factor activity
EZV63_RS32770	COG1053	succinate dehydrogenase
EZV63_RS32775	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EZV63_RS32800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZV63_RS32810	COG3360	Dodecin
EZV63_RS32815	COG2182	Extracellular solute-binding protein
EZV63_RS32820	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
EZV63_RS32825	COG0121	glutamine amidotransferase
EZV63_RS32830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EZV63_RS32835	COG3572	ergothioneine biosynthetic process
EZV63_RS32850	COG2084	Dehydrogenase
EZV63_RS32855	COG3467	pyridoxamine 5'-phosphate
EZV63_RS32880	COG0596	Alpha beta hydrolase
EZV63_RS32885	COG3903	Transcriptional regulator
EZV63_RS32885	COG3629	intracellular signal transduction
EZV63_RS32900	COG1053	succinate dehydrogenase
EZV63_RS32900	COG3976	FMN-binding domain protein
EZV63_RS32920	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS32930	COG0583	DNA-binding transcription factor activity
EZV63_RS32945	COG1609	Transcriptional regulator
EZV63_RS32950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EZV63_RS32960	COG0242	peptide deformylase activity
EZV63_RS33000	COG0439	Biotin carboxylase
EZV63_RS33010	COG1802	Transcriptional regulator
EZV63_RS33025	COG0659	secondary active sulfate transmembrane transporter activity
EZV63_RS33055	COG1725	Transcriptional regulator
EZV63_RS33060	COG1131	(ABC) transporter
EZV63_RS33075	COG1073	alpha beta
EZV63_RS33090	COG1309	transcriptional regulator
EZV63_RS33115	COG1695	Transcriptional regulator
EZV63_RS33135	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZV63_RS33140	COG3246	L-lysine catabolic process to acetate
EZV63_RS33150	COG1132	(ABC) transporter
EZV63_RS33160	COG0494	nUDIX hydrolase
EZV63_RS33170	COG0738	Major facilitator superfamily
EZV63_RS33175	COG3226	Transcriptional regulator
EZV63_RS33185	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EZV63_RS33200	COG1216	Glycosyl transferase, family 2
EZV63_RS33210	COG4310	Domain of unknown function (DUF2172)
EZV63_RS33225	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EZV63_RS33280	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EZV63_RS33320	COG4948	Mandelate Racemase Muconate Lactonizing
EZV63_RS33325	COG0800	Aldolase
EZV63_RS33375	COG0702	epimerase
EZV63_RS33380	COG1846	Transcriptional regulator
EZV63_RS33385	COG2409	Drug exporters of the RND superfamily
EZV63_RS33400	COG0668	transmembrane transport
EZV63_RS33440	COG3540	Alkaline phosphatase
EZV63_RS33460	COG1556	Lactate utilization protein
EZV63_RS33465	COG1139	Iron-sulfur cluster binding protein
EZV63_RS33470	COG0247	lactate metabolic process
EZV63_RS33475	COG1070	Carbohydrate kinase
EZV63_RS33480	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS33480	COG3347	Dehydrogenase
EZV63_RS33485	COG4952	isomerase
EZV63_RS33490	COG1129	ABC transporter
EZV63_RS33495	COG1172	Belongs to the binding-protein-dependent transport system permease family
EZV63_RS33515	COG1609	Transcriptional regulator
EZV63_RS33530	COG1357	PFAM Pentapeptide repeats (8 copies)
EZV63_RS33535	COG2124	cytochrome p450
EZV63_RS33535	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EZV63_RS33540	COG1309	transcriptional regulator
EZV63_RS33550	COG2706	6-phosphogluconolactonase activity
EZV63_RS33595	COG1796	DNA polymerase
EZV63_RS33595	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EZV63_RS33655	COG2124	cytochrome p450
EZV63_RS33670	COG0435	Glutathione S-transferase
EZV63_RS33685	COG2124	cytochrome p450
EZV63_RS33700	COG0667	Aldo Keto reductase
EZV63_RS33720	COG1304	FMN binding
EZV63_RS33735	COG2890	protein-(glutamine-N5) methyltransferase activity
EZV63_RS33750	COG0248	Ppx GppA phosphatase
EZV63_RS33805	COG1132	(ABC) transporter
EZV63_RS33820	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS33830	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS33860	COG1309	transcriptional regulator
EZV63_RS33930	COG0673	inositol 2-dehydrogenase activity
EZV63_RS33945	COG2508	Transcriptional regulator
EZV63_RS33955	COG0411	ABC transporter
EZV63_RS34040	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EZV63_RS34045	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EZV63_RS34050	COG2080	2 iron, 2 sulfur cluster binding
EZV63_RS34060	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS34090	COG0477	Major facilitator Superfamily
EZV63_RS34110	COG3290	protein histidine kinase activity
EZV63_RS34145	COG0277	FAD linked oxidase domain protein
EZV63_RS34170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EZV63_RS34175	COG0395	ABC-type sugar transport system, permease component
EZV63_RS34180	COG1175	transmembrane transport
EZV63_RS34200	COG2264	protein methyltransferase activity
EZV63_RS34205	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS34245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZV63_RS34250	COG1120	ATPase activity
EZV63_RS34260	COG0488	(ABC) transporter
EZV63_RS34280	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EZV63_RS34285	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EZV63_RS34300	COG1595	DNA-templated transcription, initiation
EZV63_RS34350	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
EZV63_RS34405	COG0505	Belongs to the CarA family
EZV63_RS34415	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
EZV63_RS34420	COG1191	sigma factor activity
EZV63_RS34430	COG0783	Belongs to the Dps family
EZV63_RS34435	COG0655	NAD(P)H dehydrogenase (quinone) activity
EZV63_RS34440	COG2226	methyltransferase
EZV63_RS34460	COG2018	Roadblock/LC7 domain
EZV63_RS34475	COG2124	cytochrome p450
EZV63_RS34490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZV63_RS34500	COG2186	Transcriptional regulator
EZV63_RS34510	COG2376	Dihydroxyacetone kinase
EZV63_RS34515	COG0698	ribose 5-phosphate isomerase
EZV63_RS34520	COG0149	triose-phosphate isomerase activity
EZV63_RS34525	COG1082	Xylose isomerase domain protein TIM barrel
EZV63_RS34530	COG2084	Dehydrogenase
EZV63_RS34535	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EZV63_RS34540	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EZV63_RS34575	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EZV63_RS34600	COG0745	RESPONSE REGULATOR receiver
EZV63_RS34605	COG2205	protein histidine kinase activity
EZV63_RS34610	COG2340	Cysteine-rich secretory protein family
EZV63_RS34615	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EZV63_RS34630	COG1196	nuclear chromosome segregation
EZV63_RS34630	COG0739	heme binding
EZV63_RS34630	COG0741	lytic transglycosylase activity
EZV63_RS34635	COG2208	phosphoserine phosphatase activity
EZV63_RS34640	COG1486	melibiose metabolic process
EZV63_RS34645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EZV63_RS34650	COG0395	ABC-type sugar transport system, permease component
EZV63_RS34690	COG1278	Cold shock
EZV63_RS34700	COG3415	Transposase
EZV63_RS34700	COG2801	Transposase and inactivated derivatives
EZV63_RS34715	COG3386	PFAM SMP-30 Gluconolaconase
EZV63_RS34720	COG4221	oxidoreductase activity
EZV63_RS34740	COG4221	oxidoreductase activity
EZV63_RS34755	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EZV63_RS34765	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EZV63_RS34795	COG3486	L-lysine 6-monooxygenase (NADPH) activity
EZV63_RS34800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZV63_RS34805	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZV63_RS34810	COG1120	ATPase activity
EZV63_RS34815	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EZV63_RS34830	COG1132	(ABC) transporter
EZV63_RS34835	COG2382	esterase
EZV63_RS34885	COG0789	Transcriptional regulator
EZV63_RS34895	COG0659	secondary active sulfate transmembrane transporter activity
EZV63_RS34900	COG0346	lactoylglutathione lyase activity
EZV63_RS34905	COG1120	ATPase activity
EZV63_RS34910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EZV63_RS34920	COG0803	Belongs to the bacterial solute-binding protein 9 family
EZV63_RS34940	COG4172	Belongs to the ABC transporter superfamily
EZV63_RS34945	COG0601	transmembrane transport
EZV63_RS34955	COG0747	negative chemotaxis
EZV63_RS34990	COG1472	Belongs to the glycosyl hydrolase 3 family
EZV63_RS35000	COG1609	Transcriptional regulator
EZV63_RS35005	COG0395	ABC-type sugar transport system, permease component
EZV63_RS35010	COG1175	transmembrane transport
EZV63_RS35020	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EZV63_RS35055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZV63_RS35065	COG0402	S-adenosylhomocysteine deaminase activity
EZV63_RS35070	COG0477	Major facilitator Superfamily
EZV63_RS35095	COG1984	allophanate hydrolase subunit 2
EZV63_RS35100	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EZV63_RS35105	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EZV63_RS35120	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EZV63_RS35130	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EZV63_RS35135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EZV63_RS35135	COG1263	PTS System
EZV63_RS35145	COG2188	Transcriptional regulator
EZV63_RS35150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZV63_RS35155	COG0028	Belongs to the TPP enzyme family
EZV63_RS35165	COG0477	Major facilitator Superfamily
EZV63_RS35200	COG0667	Aldo Keto reductase
EZV63_RS35235	COG1609	Transcriptional regulator
EZV63_RS35260	COG1175	transmembrane transport
EZV63_RS35265	COG0395	ABC-type sugar transport system, permease component
EZV63_RS35275	COG0460	homoserine dehydrogenase
EZV63_RS35290	COG1136	(ABC) transporter
EZV63_RS35300	COG0577	efflux transmembrane transporter activity
EZV63_RS35305	COG0745	RESPONSE REGULATOR receiver
EZV63_RS35310	COG2205	protein histidine kinase activity
EZV63_RS35335	COG1940	carbohydrate kinase activity
EZV63_RS35340	COG3345	alpha-galactosidase
EZV63_RS35350	COG0395	ABC-type sugar transport system, permease component
EZV63_RS35355	COG1175	transmembrane transport
EZV63_RS35365	COG1891	lyase activity
EZV63_RS35380	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EZV63_RS35400	COG0477	Major facilitator Superfamily
EZV63_RS35410	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS35415	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EZV63_RS35430	COG1609	Transcriptional regulator
EZV63_RS35435	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EZV63_RS35440	COG0583	DNA-binding transcription factor activity
EZV63_RS35445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EZV63_RS35450	COG0366	Alpha amylase catalytic
EZV63_RS35470	COG1609	Transcriptional regulator
EZV63_RS35490	COG2132	Multicopper oxidase
EZV63_RS35495	COG2409	Drug exporters of the RND superfamily
EZV63_RS35500	COG1309	transcriptional regulator
EZV63_RS35525	COG0515	serine threonine protein kinase
EZV63_RS35535	COG1902	pentaerythritol trinitrate reductase activity
EZV63_RS35545	COG0515	serine threonine protein kinase
EZV63_RS35555	COG1472	Belongs to the glycosyl hydrolase 3 family
EZV63_RS35570	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EZV63_RS35580	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EZV63_RS35590	COG0667	Aldo Keto reductase
EZV63_RS35600	COG0640	Transcriptional regulator
EZV63_RS35605	COG1902	pentaerythritol trinitrate reductase activity
EZV63_RS35655	COG2124	cytochrome p450
EZV63_RS35670	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS35695	COG1028	Short-chain dehydrogenase reductase Sdr
EZV63_RS35820	COG0583	DNA-binding transcription factor activity
EZV63_RS35825	COG0483	inositol monophosphate 1-phosphatase activity
EZV63_RS35935	COG0494	nUDIX hydrolase
EZV63_RS36340	COG3971	2-oxopent-4-enoate hydratase activity
EZV63_RS36345	COG4569	acetaldehyde dehydrogenase (acetylating) activity
EZV63_RS36355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EZV63_RS36365	COG2301	Belongs to the HpcH HpaI aldolase family
EZV63_RS36385	COG1793	dna ligase
EZV63_RS36400	COG0159	tryptophan synthase activity
EZV63_RS36545	COG5002	protein histidine kinase activity
EZV63_RS36545	COG2176	DNA-directed DNA polymerase activity