locus-tag	class	description
D1J60_RS00010	COG2188	Transcriptional regulator
D1J60_RS00145	COG1737	Transcriptional regulator
D1J60_RS00270	COG3629	intracellular signal transduction
D1J60_RS00270	COG3903	Transcriptional regulator
D1J60_RS00335	COG3291	Pkd domain containing protein
D1J60_RS00345	COG0151	Belongs to the GarS family
D1J60_RS00455	COG0515	serine threonine protein kinase
D1J60_RS00455	COG2815	serine threonine protein kinase
D1J60_RS00480	COG0789	Transcriptional regulator
D1J60_RS00485	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS00495	COG2409	Drug exporters of the RND superfamily
D1J60_RS00500	COG1846	Transcriptional regulator
D1J60_RS00525	COG0702	epimerase
D1J60_RS00530	COG3046	protein related to deoxyribodipyrimidine photolyase
D1J60_RS00555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D1J60_RS00600	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1J60_RS00610	COG2208	phosphoserine phosphatase activity
D1J60_RS00610	COG2770	Histidine kinase
D1J60_RS00650	COG2205	protein histidine kinase activity
D1J60_RS00655	COG0745	RESPONSE REGULATOR receiver
D1J60_RS00685	COG2340	Cysteine-rich secretory protein family
D1J60_RS00690	COG4221	oxidoreductase activity
D1J60_RS00695	COG0583	DNA-binding transcription factor activity
D1J60_RS00720	COG0009	L-threonylcarbamoyladenylate synthase
D1J60_RS00735	COG0477	Major facilitator Superfamily
D1J60_RS00750	COG2207	Transcriptional regulator
D1J60_RS00770	COG2890	protein-(glutamine-N5) methyltransferase activity
D1J60_RS00780	COG0148	phosphopyruvate hydratase activity
D1J60_RS00795	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D1J60_RS00835	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D1J60_RS00840	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS00915	COG1295	ribonuclease BN
D1J60_RS00935	COG2814	Major facilitator Superfamily
D1J60_RS00955	COG1191	sigma factor activity
D1J60_RS01015	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
D1J60_RS01030	COG1428	Deoxynucleoside kinase
D1J60_RS01045	COG1309	transcriptional regulator
D1J60_RS01050	COG0702	epimerase
D1J60_RS01055	COG3631	Ketosteroid isomerase-related protein
D1J60_RS01105	COG1834	amidinotransferase
D1J60_RS01110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1J60_RS01120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1J60_RS01140	COG0515	serine threonine protein kinase
D1J60_RS01200	COG0318	PFAM AMP-dependent synthetase and ligase
D1J60_RS01205	COG3291	Pkd domain containing protein
D1J60_RS01215	COG0235	Class ii aldolase
D1J60_RS01240	COG0477	Major facilitator Superfamily
D1J60_RS01275	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D1J60_RS01300	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS01320	COG4221	oxidoreductase activity
D1J60_RS01385	COG0456	acetyltransferase
D1J60_RS01390	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D1J60_RS01400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1J60_RS01405	COG1959	2 iron, 2 sulfur cluster binding
D1J60_RS01425	COG2205	protein histidine kinase activity
D1J60_RS01425	COG2972	Histidine kinase
D1J60_RS01480	COG0531	amino acid
D1J60_RS01485	COG1595	DNA-templated transcription, initiation
D1J60_RS01580	COG2340	Cysteine-rich secretory protein family
D1J60_RS01615	COG0346	lactoylglutathione lyase activity
D1J60_RS01625	COG0456	acetyltransferase
D1J60_RS01630	COG0667	Aldo Keto reductase
D1J60_RS01635	COG1309	transcriptional regulator
D1J60_RS01645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1J60_RS01690	COG0137	argininosuccinate synthase activity
D1J60_RS01715	COG3250	beta-galactosidase activity
D1J60_RS01720	COG0477	Major facilitator Superfamily
D1J60_RS01725	COG0745	RESPONSE REGULATOR receiver
D1J60_RS01730	COG2205	protein histidine kinase activity
D1J60_RS01755	COG0154	amidase activity
D1J60_RS01760	COG3226	Transcriptional regulator
D1J60_RS01790	COG4989	oxidoreductase activity
D1J60_RS01820	COG0456	acetyltransferase
D1J60_RS01820	COG0454	-acetyltransferase
D1J60_RS01825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1J60_RS01840	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS01850	COG5297	Belongs to the glycosyl hydrolase family 6
D1J60_RS01850	COG4733	cellulase activity
D1J60_RS01880	COG2124	cytochrome p450
D1J60_RS01910	COG0298	carbon dioxide binding
D1J60_RS01925	COG0375	protein maturation
D1J60_RS01965	COG1024	Enoyl-CoA hydratase
D1J60_RS01965	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D1J60_RS02000	COG0367	asparagine synthase
D1J60_RS02010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1J60_RS02020	COG2175	clavaminate synthase activity
D1J60_RS02035	COG1129	ABC transporter
D1J60_RS02040	COG1172	Belongs to the binding-protein-dependent transport system permease family
D1J60_RS02060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1J60_RS02105	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1J60_RS02110	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D1J60_RS02115	COG2080	2 iron, 2 sulfur cluster binding
D1J60_RS02140	COG1573	uracil-dna glycosylase
D1J60_RS02180	COG1024	Enoyl-CoA hydratase
D1J60_RS02185	COG0028	Belongs to the TPP enzyme family
D1J60_RS02225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1J60_RS02230	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D1J60_RS02235	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D1J60_RS02315	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1J60_RS02330	COG0402	S-adenosylhomocysteine deaminase activity
D1J60_RS02335	COG2233	PERMEase
D1J60_RS02340	COG0402	S-adenosylhomocysteine deaminase activity
D1J60_RS02375	COG1609	Transcriptional regulator
D1J60_RS02380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1J60_RS02395	COG2223	nitrite transmembrane transporter activity
D1J60_RS02415	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D1J60_RS02470	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D1J60_RS02485	COG4310	Domain of unknown function (DUF2172)
D1J60_RS02495	COG1215	transferase activity, transferring glycosyl groups
D1J60_RS02505	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
D1J60_RS02510	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D1J60_RS02520	COG0500	methyltransferase
D1J60_RS02525	COG2197	response regulator
D1J60_RS02530	COG4585	Histidine kinase
D1J60_RS02545	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D1J60_RS02575	COG0583	DNA-binding transcription factor activity
D1J60_RS02585	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D1J60_RS02590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1J60_RS02595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1J60_RS02600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1J60_RS02625	COG1796	DNA polymerase
D1J60_RS02625	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D1J60_RS02630	COG1982	Orn Lys Arg decarboxylase major
D1J60_RS02675	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D1J60_RS02700	COG0662	Cupin 2, conserved barrel domain protein
D1J60_RS02720	COG2197	response regulator
D1J60_RS02725	COG4585	Histidine kinase
D1J60_RS02730	COG3693	PFAM glycoside hydrolase, family 10
D1J60_RS02735	COG0395	ABC-type sugar transport system, permease component
D1J60_RS02755	COG1472	Belongs to the glycosyl hydrolase 3 family
D1J60_RS02760	COG3507	Belongs to the glycosyl hydrolase 43 family
D1J60_RS02785	COG1609	Transcriptional regulator
D1J60_RS02790	COG1172	Belongs to the binding-protein-dependent transport system permease family
D1J60_RS02795	COG1172	Belongs to the binding-protein-dependent transport system permease family
D1J60_RS02805	COG1879	ABC-type sugar transport system periplasmic component
D1J60_RS02815	COG2160	L-arabinose isomerase activity
D1J60_RS02820	COG5297	Belongs to the glycosyl hydrolase family 6
D1J60_RS02840	COG0395	ABC-type sugar transport system, permease component
D1J60_RS02855	COG1070	Carbohydrate kinase
D1J60_RS02875	COG4214	carbohydrate transport
D1J60_RS02890	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D1J60_RS02900	COG1113	amino acid transport
D1J60_RS02925	COG1595	DNA-templated transcription, initiation
D1J60_RS02950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1J60_RS02955	COG4521	taurine ABC transporter
D1J60_RS02960	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D1J60_RS02975	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D1J60_RS03010	COG0477	Major facilitator Superfamily
D1J60_RS03030	COG1725	Transcriptional regulator
D1J60_RS03040	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D1J60_RS03045	COG2011	ABC-type metal ion transport system permease component
D1J60_RS03065	COG1349	DNA-binding transcription factor activity
D1J60_RS03070	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D1J60_RS03080	COG2135	peptidase activity
D1J60_RS03110	COG1505	serine-type exopeptidase activity
D1J60_RS03115	COG0667	Aldo Keto reductase
D1J60_RS03130	COG0477	Major facilitator Superfamily
D1J60_RS03150	COG1131	(ABC) transporter
D1J60_RS03155	COG1725	Transcriptional regulator
D1J60_RS03160	COG1686	Belongs to the peptidase S11 family
D1J60_RS03270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1J60_RS03275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1J60_RS03310	COG2197	response regulator
D1J60_RS03325	COG1764	response to oxidative stress
D1J60_RS03330	COG1846	Transcriptional regulator
D1J60_RS03355	COG0714	Associated with various cellular activities
D1J60_RS03370	COG0667	Aldo Keto reductase
D1J60_RS03400	COG1404	Belongs to the peptidase S8 family
D1J60_RS03460	COG0189	ligase activity
D1J60_RS03485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1J60_RS03490	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D1J60_RS03510	COG2188	Transcriptional regulator
D1J60_RS03535	COG1136	(ABC) transporter
D1J60_RS03535	COG4591	ABC-type transport system involved in lipoprotein release permease component
D1J60_RS03550	COG0577	efflux transmembrane transporter activity
D1J60_RS03550	COG1136	(ABC) transporter
D1J60_RS03565	COG4941	Belongs to the sigma-70 factor family
D1J60_RS03585	COG2124	cytochrome p450
D1J60_RS03595	COG1278	Cold shock
D1J60_RS03605	COG1846	Transcriptional regulator
D1J60_RS03610	COG0513	Belongs to the DEAD box helicase family
D1J60_RS03635	COG2080	2 iron, 2 sulfur cluster binding
D1J60_RS03635	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1J60_RS03670	COG2130	NADP-dependent
D1J60_RS03775	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D1J60_RS03785	COG0531	amino acid
D1J60_RS03800	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D1J60_RS03835	COG0531	amino acid
D1J60_RS03850	COG2010	Cytochrome c
D1J60_RS03850	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1J60_RS03875	COG1053	succinate dehydrogenase
D1J60_RS03910	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D1J60_RS03910	COG1672	PFAM Archaeal ATPase
D1J60_RS03950	COG2267	carboxylic ester hydrolase activity
D1J60_RS03965	COG0387	Pfam Sodium calcium exchanger
D1J60_RS03975	COG2070	2-Nitropropane dioxygenase
D1J60_RS03980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1J60_RS04020	COG0515	serine threonine protein kinase
D1J60_RS04020	COG2815	serine threonine protein kinase
D1J60_RS04040	COG1113	amino acid transport
D1J60_RS04050	COG2304	oxidoreductase activity
D1J60_RS04090	COG1960	acyl-CoA dehydrogenase activity
D1J60_RS04100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1J60_RS04105	COG1349	DNA-binding transcription factor activity
D1J60_RS04125	COG3896	Chloramphenicol phosphotransferase-like protein
D1J60_RS04135	COG0156	8-amino-7-oxononanoate synthase activity
D1J60_RS04140	COG1063	alcohol dehydrogenase
D1J60_RS04165	COG3387	PFAM Glycoside hydrolase 15-related
D1J60_RS04170	COG2259	Doxx family
D1J60_RS04185	COG2376	Dihydroxyacetone kinase
D1J60_RS04190	COG1461	Dihydroxyacetone kinase
D1J60_RS04210	COG0725	ABC transporter, periplasmic molybdate-binding protein
D1J60_RS04250	COG1716	ATPase activity
D1J60_RS04250	COG1131	(ABC) transporter
D1J60_RS04250	COG0842	Transport permease protein
D1J60_RS04280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1J60_RS04310	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D1J60_RS04315	COG1215	transferase activity, transferring glycosyl groups
D1J60_RS04335	COG0464	growth
D1J60_RS04355	COG1940	carbohydrate kinase activity
D1J60_RS04385	COG0445	tRNA wobble uridine modification
D1J60_RS04425	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D1J60_RS04480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1J60_RS04490	COG0584	glycerophosphoryl diester phosphodiesterase
D1J60_RS04510	COG0671	phosphoesterase, PA-phosphatase related
D1J60_RS04515	COG1309	transcriptional regulator
D1J60_RS04530	COG0493	'glutamate synthase
D1J60_RS04535	COG0640	Transcriptional regulator
D1J60_RS04540	COG1902	pentaerythritol trinitrate reductase activity
D1J60_RS04550	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D1J60_RS04560	COG2706	6-phosphogluconolactonase activity
D1J60_RS04565	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
D1J60_RS04585	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1J60_RS04590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1J60_RS04595	COG0406	alpha-ribazole phosphatase activity
D1J60_RS04630	COG0477	Major facilitator Superfamily
D1J60_RS04650	COG2072	flavoprotein involved in K transport
D1J60_RS04665	COG1132	(ABC) transporter
D1J60_RS04680	COG1132	(ABC) transporter
D1J60_RS04685	COG1132	(ABC) transporter
D1J60_RS04700	COG1946	Acyl-CoA thioesterase
D1J60_RS04705	COG3012	SEC-C Motif Domain Protein
D1J60_RS04715	COG2018	Roadblock/LC7 domain
D1J60_RS04775	COG1012	belongs to the aldehyde dehydrogenase family
D1J60_RS04785	COG1737	Transcriptional regulator
D1J60_RS04790	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D1J60_RS04805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1J60_RS04935	COG1278	Cold shock
D1J60_RS04965	COG0659	secondary active sulfate transmembrane transporter activity
D1J60_RS04975	COG2824	Alkylphosphonate utilization operon protein PhnA
D1J60_RS04995	COG0617	tRNA 3'-terminal CCA addition
D1J60_RS04995	COG0517	IMP dehydrogenase activity
D1J60_RS04995	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D1J60_RS05020	COG0517	IMP dehydrogenase activity
D1J60_RS05020	COG0516	GMP reductase activity
D1J60_RS05035	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
D1J60_RS05070	COG0589	response to stress
D1J60_RS05085	COG1063	alcohol dehydrogenase
D1J60_RS05090	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D1J60_RS05100	COG0516	GMP reductase activity
D1J60_RS05100	COG0517	IMP dehydrogenase activity
D1J60_RS05110	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D1J60_RS05120	COG0254	rRNA binding
D1J60_RS05130	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D1J60_RS05135	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D1J60_RS05145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1J60_RS05150	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1J60_RS05180	COG2376	Dihydroxyacetone kinase
D1J60_RS05185	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D1J60_RS05190	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D1J60_RS05195	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D1J60_RS05225	COG3173	Aminoglycoside phosphotransferase
D1J60_RS05245	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1J60_RS05250	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D1J60_RS05255	COG0673	inositol 2-dehydrogenase activity
D1J60_RS05265	COG2175	clavaminate synthase activity
D1J60_RS05280	COG1509	lysine 2,3-aminomutase activity
D1J60_RS05305	COG1132	(ABC) transporter
D1J60_RS05310	COG1132	(ABC) transporter
D1J60_RS05350	COG1404	Belongs to the peptidase S8 family
D1J60_RS05400	COG1505	serine-type exopeptidase activity
D1J60_RS05425	COG2815	serine threonine protein kinase
D1J60_RS05425	COG0515	serine threonine protein kinase
D1J60_RS05435	COG2814	Major facilitator Superfamily
D1J60_RS05440	COG2208	phosphoserine phosphatase activity
D1J60_RS05440	COG2770	Histidine kinase
D1J60_RS05455	COG0154	amidase activity
D1J60_RS05465	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
D1J60_RS05485	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D1J60_RS05535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1J60_RS05540	COG0514	ATP-dependent DNA helicase (RecQ)
D1J60_RS05550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1J60_RS05560	COG2824	Alkylphosphonate utilization operon protein PhnA
D1J60_RS05640	COG4608	Belongs to the ABC transporter superfamily
D1J60_RS05650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1J60_RS05655	COG0601	transmembrane transport
D1J60_RS05690	COG1960	acyl-CoA dehydrogenase activity
D1J60_RS05700	COG0242	peptide deformylase activity
D1J60_RS05710	COG3442	glutamine amidotransferase
D1J60_RS05715	COG0205	6-phosphofructokinase activity
D1J60_RS05725	COG0204	Acyl-transferase
D1J60_RS05735	COG0829	nickel cation binding
D1J60_RS05740	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D1J60_RS05745	COG0830	nickel cation binding
D1J60_RS05750	COG0804	urea catabolic process
D1J60_RS05755	COG0832	Belongs to the urease beta subunit family
D1J60_RS05760	COG0831	urea catabolic process
D1J60_RS05780	COG0156	8-amino-7-oxononanoate synthase activity
D1J60_RS05785	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D1J60_RS05790	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1J60_RS05795	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D1J60_RS05805	COG2226	methyltransferase
D1J60_RS05810	COG2815	serine threonine protein kinase
D1J60_RS05810	COG0515	serine threonine protein kinase
D1J60_RS05815	COG0456	acetyltransferase
D1J60_RS05835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D1J60_RS05860	COG4585	Histidine kinase
D1J60_RS05865	COG2197	response regulator
D1J60_RS05870	COG1940	carbohydrate kinase activity
D1J60_RS05875	COG2188	Transcriptional regulator
D1J60_RS05880	COG2267	carboxylic ester hydrolase activity
D1J60_RS05905	COG1522	sequence-specific DNA binding
D1J60_RS05910	COG0419	ATPase involved in DNA repair
D1J60_RS05915	COG0420	3'-5' exonuclease activity
D1J60_RS05925	COG1739	Uncharacterized protein family UPF0029
D1J60_RS05930	COG1832	CoA-binding protein
D1J60_RS05945	COG0110	maltose O-acetyltransferase activity
D1J60_RS05985	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1J60_RS05995	COG1968	undecaprenyl-diphosphatase activity
D1J60_RS06010	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D1J60_RS06020	COG2318	DinB family
D1J60_RS06035	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D1J60_RS06095	COG0697	spore germination
D1J60_RS06110	COG1695	Transcriptional regulator
D1J60_RS06140	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1J60_RS06140	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1J60_RS06150	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D1J60_RS06170	COG1716	ATPase activity
D1J60_RS06190	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D1J60_RS06225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1J60_RS06235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1J60_RS06260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1J60_RS06275	COG2018	Roadblock/LC7 domain
D1J60_RS06310	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D1J60_RS06315	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D1J60_RS06320	COG1984	allophanate hydrolase subunit 2
D1J60_RS06345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1J60_RS06355	COG2270	Major facilitator Superfamily
D1J60_RS06370	COG0463	Glycosyl transferase, family 2
D1J60_RS06415	COG1960	acyl-CoA dehydrogenase activity
D1J60_RS06420	COG1309	transcriptional regulator
D1J60_RS06460	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D1J60_RS06460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1J60_RS06480	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D1J60_RS06485	COG0140	phosphoribosyl-ATP diphosphatase activity
D1J60_RS06490	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D1J60_RS06495	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1J60_RS06495	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1J60_RS06500	COG3201	nicotinamide mononucleotide transporter
D1J60_RS06510	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1J60_RS06510	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1J60_RS06525	COG1940	carbohydrate kinase activity
D1J60_RS06525	COG1846	Transcriptional regulator
D1J60_RS06530	COG0738	Major facilitator superfamily
D1J60_RS06535	COG2233	PERMEase
D1J60_RS06550	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1J60_RS06575	COG0531	amino acid
D1J60_RS06580	COG2755	lipolytic protein G-D-S-L family
D1J60_RS06600	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1J60_RS06605	COG3275	phosphorelay sensor kinase activity
D1J60_RS06630	COG3548	integral membrane protein
D1J60_RS06670	COG1012	belongs to the aldehyde dehydrogenase family
D1J60_RS06680	COG1663	tetraacyldisaccharide 4'-kinase activity
D1J60_RS06685	COG2770	Histidine kinase
D1J60_RS06685	COG2208	phosphoserine phosphatase activity
D1J60_RS06705	COG1366	Belongs to the anti-sigma-factor antagonist family
D1J60_RS06720	COG0693	protein deglycase activity
D1J60_RS06745	COG0028	Belongs to the TPP enzyme family
D1J60_RS06760	COG0492	ferredoxin-NADP+ reductase activity
D1J60_RS06775	COG2346	COG2346, Truncated hemoglobins
D1J60_RS06800	COG2390	Transcriptional regulator
D1J60_RS06805	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D1J60_RS06825	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D1J60_RS06840	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D1J60_RS06855	COG0194	GDP metabolic process
D1J60_RS06865	COG0284	orotidine-5'-phosphate decarboxylase activity
D1J60_RS06870	COG0167	dihydroorotate dehydrogenase activity
D1J60_RS06875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D1J60_RS06880	COG0505	Belongs to the CarA family
D1J60_RS06890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1J60_RS06895	COG0540	Belongs to the ATCase OTCase family
D1J60_RS06900	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D1J60_RS06910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D1J60_RS06915	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D1J60_RS06920	COG0006	proline dipeptidase activity
D1J60_RS06930	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D1J60_RS06935	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D1J60_RS06940	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D1J60_RS06945	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D1J60_RS06950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D1J60_RS06965	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D1J60_RS06970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D1J60_RS06985	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D1J60_RS07005	COG0124	histidyl-tRNA synthetase
D1J60_RS07015	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D1J60_RS07020	COG1196	nuclear chromosome segregation
D1J60_RS07030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1J60_RS07035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D1J60_RS07040	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1J60_RS07045	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1J60_RS07055	COG2255	four-way junction helicase activity
D1J60_RS07060	COG0632	four-way junction helicase activity
D1J60_RS07065	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D1J60_RS07070	COG0217	transcriptional regulatory protein
D1J60_RS07075	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D1J60_RS07080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D1J60_RS07090	COG0438	transferase activity, transferring glycosyl groups
D1J60_RS07095	COG1560	Kdo2-lipid A biosynthetic process
D1J60_RS07100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D1J60_RS07120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D1J60_RS07145	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D1J60_RS07210	COG0456	acetyltransferase
D1J60_RS07210	COG0454	-acetyltransferase
D1J60_RS07220	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1J60_RS07265	COG1648	precorrin-2 dehydrogenase activity
D1J60_RS07265	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1J60_RS07290	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D1J60_RS07305	COG1464	Belongs to the NlpA lipoprotein family
D1J60_RS07310	COG2011	ABC-type metal ion transport system permease component
D1J60_RS07315	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D1J60_RS07340	COG0584	glycerophosphoryl diester phosphodiesterase
D1J60_RS07345	COG0204	Acyl-transferase
D1J60_RS07345	COG0318	PFAM AMP-dependent synthetase and ligase
D1J60_RS07355	COG0477	Major facilitator Superfamily
D1J60_RS07375	COG0165	Argininosuccinate lyase
D1J60_RS07390	COG1438	arginine binding
D1J60_RS07395	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1J60_RS07400	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D1J60_RS07405	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D1J60_RS07410	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D1J60_RS07430	COG0697	spore germination
D1J60_RS07440	COG1649	PFAM Uncharacterised BCR, COG1649
D1J60_RS07460	COG0072	phenylalanine-tRNA ligase activity
D1J60_RS07460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1J60_RS07465	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D1J60_RS07470	COG5002	protein histidine kinase activity
D1J60_RS07475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1J60_RS07480	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D1J60_RS07485	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D1J60_RS07490	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D1J60_RS07530	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS07535	COG1012	belongs to the aldehyde dehydrogenase family
D1J60_RS07540	COG0174	glutamine synthetase
D1J60_RS07550	COG1113	amino acid transport
D1J60_RS07555	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D1J60_RS07600	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1J60_RS07620	COG1309	transcriptional regulator
D1J60_RS07635	COG0805	protein transport
D1J60_RS07640	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1J60_RS07675	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D1J60_RS07685	COG1609	Transcriptional regulator
D1J60_RS07690	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D1J60_RS07695	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D1J60_RS07710	COG4122	O-methyltransferase activity
D1J60_RS07715	COG1222	aaa ATPase
D1J60_RS07735	COG1994	Peptidase M50
D1J60_RS07735	COG0517	IMP dehydrogenase activity
D1J60_RS07745	COG2197	response regulator
D1J60_RS07755	COG4166	transmembrane transport
D1J60_RS07765	COG1410	methionine synthase
D1J60_RS07765	COG0646	methionine synthase
D1J60_RS07770	COG1414	Transcriptional regulator
D1J60_RS07775	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D1J60_RS07780	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D1J60_RS07785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D1J60_RS07795	COG0215	cysteine-tRNA ligase activity
D1J60_RS07815	COG0598	Magnesium transport protein CorA
D1J60_RS07825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1J60_RS07830	COG0667	Aldo Keto reductase
D1J60_RS07860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1J60_RS07875	COG1113	amino acid transport
D1J60_RS07900	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D1J60_RS07905	COG2149	membrane
D1J60_RS07930	COG1960	acyl-CoA dehydrogenase activity
D1J60_RS07940	COG1902	pentaerythritol trinitrate reductase activity
D1J60_RS07960	COG3876	Protein conserved in bacteria
D1J60_RS08000	COG1960	acyl-CoA dehydrogenase activity
D1J60_RS08020	COG2851	Citrate transporter
D1J60_RS08025	COG0243	molybdopterin cofactor binding
D1J60_RS08030	COG1309	transcriptional regulator
D1J60_RS08050	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D1J60_RS08055	COG2188	Transcriptional regulator
D1J60_RS08085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1J60_RS08095	COG0515	serine threonine protein kinase
D1J60_RS08095	COG2815	serine threonine protein kinase
D1J60_RS08100	COG2755	lipolytic protein G-D-S-L family
D1J60_RS08110	COG1725	Transcriptional regulator
D1J60_RS08135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D1J60_RS08140	COG0587	DNA-directed DNA polymerase activity
D1J60_RS08175	COG0641	radical SAM
D1J60_RS08220	COG1799	cell septum assembly
D1J60_RS08225	COG1960	acyl-CoA dehydrogenase activity
D1J60_RS08230	COG0477	Major facilitator Superfamily
D1J60_RS08240	COG0671	phosphoesterase, PA-phosphatase related
D1J60_RS08265	COG1160	GTP binding
D1J60_RS08275	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D1J60_RS08305	COG3541	Predicted nucleotidyltransferase
D1J60_RS08315	COG1051	belongs to the nudix hydrolase family
D1J60_RS08330	COG1187	pseudouridine synthase activity
D1J60_RS08335	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D1J60_RS08340	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D1J60_RS08355	COG0686	Belongs to the AlaDH PNT family
D1J60_RS08365	COG0494	nUDIX hydrolase
D1J60_RS08370	COG0504	CTP synthase activity
D1J60_RS08375	COG3387	PFAM Glycoside hydrolase 15-related
D1J60_RS08380	COG0277	FAD linked oxidase domain protein
D1J60_RS08420	COG0297	glycogen (starch) synthase activity
D1J60_RS08425	COG0497	DNA recombination
D1J60_RS08430	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D1J60_RS08450	COG1120	ATPase activity
D1J60_RS08455	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1J60_RS08460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1J60_RS08465	COG0647	UMP catabolic process
D1J60_RS08505	COG2094	Belongs to the DNA glycosylase MPG family
D1J60_RS08515	COG1881	PFAM PEBP family protein
D1J60_RS08540	COG1119	ATPase activity
D1J60_RS08555	COG2197	response regulator
D1J60_RS08560	COG4585	Histidine kinase
D1J60_RS08565	COG3953	SLT domain
D1J60_RS08565	COG5280	Phage tail tape measure protein TP901
D1J60_RS08570	COG1716	ATPase activity
D1J60_RS08570	COG1131	(ABC) transporter
D1J60_RS08570	COG0842	Transport permease protein
D1J60_RS08575	COG0560	Phosphoserine phosphatase
D1J60_RS08575	COG3830	Belongs to the UPF0237 family
D1J60_RS08595	COG2186	Transcriptional regulator
D1J60_RS08605	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D1J60_RS08610	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS08625	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D1J60_RS08645	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D1J60_RS08650	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1J60_RS08665	COG1063	alcohol dehydrogenase
D1J60_RS08730	COG1024	Enoyl-CoA hydratase
D1J60_RS08740	COG0488	(ABC) transporter
D1J60_RS08760	COG1073	alpha beta
D1J60_RS08775	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D1J60_RS08780	COG1492	cobalamin metabolic process
D1J60_RS08795	COG1797	cobyrinic acid a,c-diamide synthase activity
D1J60_RS08840	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D1J60_RS08845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1J60_RS08865	COG0768	penicillin binding
D1J60_RS08870	COG2197	response regulator
D1J60_RS08875	COG4585	Histidine kinase
D1J60_RS08930	COG2171	N-acyltransferase activity
D1J60_RS08945	COG3226	Transcriptional regulator
D1J60_RS08950	COG2076	Multidrug Resistance protein
D1J60_RS08965	COG2151	metal-sulfur cluster biosynthetic enzyme
D1J60_RS08970	COG0822	iron-sulfur transferase activity
D1J60_RS08975	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1J60_RS08980	COG0396	ATPase activity
D1J60_RS08990	COG0719	Fe-S assembly protein
D1J60_RS09005	COG1131	(ABC) transporter
D1J60_RS09020	COG1612	heme a metabolic process
D1J60_RS09035	COG0109	protoheme IX farnesyltransferase activity
D1J60_RS09045	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D1J60_RS09060	COG0363	glucosamine-6-phosphate deaminase activity
D1J60_RS09065	COG0166	Belongs to the GPI family
D1J60_RS09075	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D1J60_RS09080	COG0149	triose-phosphate isomerase activity
D1J60_RS09085	COG0126	phosphoglycerate kinase activity
D1J60_RS09090	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D1J60_RS09100	COG1481	regulation of sporulation
D1J60_RS09110	COG1660	Displays ATPase and GTPase activities
D1J60_RS09115	COG0322	excinuclease ABC activity
D1J60_RS09160	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1J60_RS09170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1J60_RS09185	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D1J60_RS09205	COG3387	PFAM Glycoside hydrolase 15-related
D1J60_RS09225	COG0477	Major facilitator Superfamily
D1J60_RS09245	COG0556	nucleotide-excision repair
D1J60_RS09250	COG0584	glycerophosphoryl diester phosphodiesterase
D1J60_RS09255	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D1J60_RS09260	COG2814	Major facilitator Superfamily
D1J60_RS09270	COG2226	methyltransferase
D1J60_RS09275	COG2313	pseudouridylate synthase activity
D1J60_RS09280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1J60_RS09320	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D1J60_RS09345	COG0237	dephospho-CoA kinase activity
D1J60_RS09360	COG2226	methyltransferase
D1J60_RS09365	COG1643	Atp-dependent helicase
D1J60_RS09405	COG2050	protein possibly involved in aromatic compounds catabolism
D1J60_RS09460	COG0789	Transcriptional regulator
D1J60_RS09480	COG0737	Belongs to the 5'-nucleotidase family
D1J60_RS09500	COG4977	sequence-specific DNA binding
D1J60_RS09510	COG0287	Prephenate dehydrogenase
D1J60_RS09510	COG1605	Chorismate mutase
D1J60_RS09545	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS09555	COG1024	Enoyl-CoA hydratase
D1J60_RS09580	COG1278	Cold shock
D1J60_RS09590	COG1309	transcriptional regulator
D1J60_RS09595	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS09600	COG1960	acyl-CoA dehydrogenase activity
D1J60_RS09605	COG1960	acyl-CoA dehydrogenase activity
D1J60_RS09625	COG0657	acetylesterase activity
D1J60_RS09670	COG0069	glutamate synthase activity
D1J60_RS09670	COG0067	glutamate synthase
D1J60_RS09670	COG0070	glutamate synthase
D1J60_RS09700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1J60_RS09705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1J60_RS09715	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D1J60_RS09725	COG0159	tryptophan synthase activity
D1J60_RS09730	COG0133	tryptophan synthase activity
D1J60_RS09740	COG0134	indole-3-glycerol-phosphate synthase activity
D1J60_RS09765	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D1J60_RS09775	COG0107	imidazoleglycerol-phosphate synthase activity
D1J60_RS09780	COG0251	oxidation-reduction process
D1J60_RS09785	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D1J60_RS09790	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D1J60_RS09800	COG0131	Imidazoleglycerol-phosphate dehydratase
D1J60_RS09805	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1J60_RS09810	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1J60_RS09825	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D1J60_RS09845	COG1432	Conserved Protein
D1J60_RS09850	COG0587	DNA-directed DNA polymerase activity
D1J60_RS09905	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D1J60_RS09920	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D1J60_RS09925	COG3599	regulation of cell shape
D1J60_RS09935	COG1799	cell septum assembly
D1J60_RS09955	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D1J60_RS09960	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D1J60_RS09970	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D1J60_RS09975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D1J60_RS09985	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D1J60_RS09990	COG0768	penicillin binding
D1J60_RS10000	COG0275	rRNA processing
D1J60_RS10010	COG0714	Associated with various cellular activities
D1J60_RS10025	COG1309	transcriptional regulator
D1J60_RS10045	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D1J60_RS10075	COG0352	thiamine-phosphate diphosphorylase activity
D1J60_RS10085	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1J60_RS10090	COG2022	thiamine diphosphate biosynthetic process
D1J60_RS10090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1J60_RS10100	COG2022	thiamine diphosphate biosynthetic process
D1J60_RS10110	COG2815	serine threonine protein kinase
D1J60_RS10110	COG0515	serine threonine protein kinase
D1J60_RS10115	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D1J60_RS10125	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D1J60_RS10130	COG2193	ferroxidase activity
D1J60_RS10140	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D1J60_RS10150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1J60_RS10155	COG0205	6-phosphofructokinase activity
D1J60_RS10160	COG2197	response regulator
D1J60_RS10165	COG4585	Histidine kinase
D1J60_RS10190	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D1J60_RS10210	COG1940	carbohydrate kinase activity
D1J60_RS10220	COG0003	Pfam Anion-transporting ATPase
D1J60_RS10245	COG0438	transferase activity, transferring glycosyl groups
D1J60_RS10260	COG0791	NLP P60 protein
D1J60_RS10285	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1J60_RS10290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D1J60_RS10295	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D1J60_RS10300	COG0723	plastoquinol--plastocyanin reductase activity
D1J60_RS10305	COG2010	Cytochrome c
D1J60_RS10310	COG1845	cytochrome c oxidase, subunit III
D1J60_RS10320	COG1376	ErfK ybiS ycfS ynhG family protein
D1J60_RS10330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D1J60_RS10335	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D1J60_RS10345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1J60_RS10365	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D1J60_RS10370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1J60_RS10375	COG2197	response regulator
D1J60_RS10380	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D1J60_RS10405	COG2226	methyltransferase
D1J60_RS10415	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
D1J60_RS10420	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D1J60_RS10425	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D1J60_RS10425	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D1J60_RS10435	COG4585	Histidine kinase
D1J60_RS10505	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D1J60_RS10510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1J60_RS10515	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1J60_RS10525	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D1J60_RS10535	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS10610	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D1J60_RS10615	COG0321	lipoyl(octanoyl) transferase activity
D1J60_RS10705	COG0745	RESPONSE REGULATOR receiver
D1J60_RS10725	COG2365	Tyrosine phosphatase family
D1J60_RS10790	COG0366	Alpha amylase catalytic
D1J60_RS10795	COG3833	ABC-type maltose transport systems, permease component
D1J60_RS10800	COG1175	transmembrane transport
D1J60_RS10810	COG0366	Alpha amylase catalytic
D1J60_RS10815	COG1609	Transcriptional regulator
D1J60_RS10830	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D1J60_RS10850	COG0174	glutamine synthetase
D1J60_RS10870	COG2267	carboxylic ester hydrolase activity
D1J60_RS10885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1J60_RS10885	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D1J60_RS10895	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D1J60_RS10915	COG1994	Peptidase M50
D1J60_RS10945	COG5398	heme oxygenase
D1J60_RS10965	COG2837	iron assimilation
D1J60_RS10970	COG0672	)-iron permease
D1J60_RS10975	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS10980	COG2814	Major facilitator Superfamily
D1J60_RS10990	COG1834	amidinotransferase
D1J60_RS11005	COG3022	response to hydroperoxide
D1J60_RS11050	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D1J60_RS11065	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS11075	COG2030	dehydratase
D1J60_RS11085	COG2124	cytochrome p450
D1J60_RS11095	COG0183	Belongs to the thiolase family
D1J60_RS11100	COG1960	acyl-CoA dehydrogenase activity
D1J60_RS11110	COG0515	serine threonine protein kinase
D1J60_RS11110	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1J60_RS11115	COG2378	regulation of single-species biofilm formation
D1J60_RS11135	COG0860	N-Acetylmuramoyl-L-alanine amidase
D1J60_RS11145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1J60_RS11175	COG0438	transferase activity, transferring glycosyl groups
D1J60_RS11180	COG1309	transcriptional regulator
D1J60_RS11210	COG1657	PFAM Prenyltransferase squalene oxidase
D1J60_RS11225	COG3845	ABC transporter
D1J60_RS11240	COG0183	Belongs to the thiolase family
D1J60_RS11245	COG2124	cytochrome p450
D1J60_RS11400	COG1358	cellular component organization or biogenesis
D1J60_RS11450	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D1J60_RS11455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1J60_RS11465	COG0477	Major facilitator Superfamily
D1J60_RS11470	COG1309	transcriptional regulator
D1J60_RS11485	COG0667	Aldo Keto reductase
D1J60_RS11490	COG0789	Transcriptional regulator
D1J60_RS11515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1J60_RS11520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1J60_RS11525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1J60_RS11545	COG1309	transcriptional regulator
D1J60_RS11565	COG1733	regulation of RNA biosynthetic process
D1J60_RS11580	COG1764	response to oxidative stress
D1J60_RS11585	COG2130	NADP-dependent
D1J60_RS11605	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D1J60_RS11610	COG1077	Cell shape determining protein MreB Mrl
D1J60_RS11630	COG0825	malonyl-CoA metabolic process
D1J60_RS11630	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D1J60_RS11650	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D1J60_RS11685	COG1070	Carbohydrate kinase
D1J60_RS11705	COG0243	molybdopterin cofactor binding
D1J60_RS11715	COG2949	membrane
D1J60_RS11725	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D1J60_RS11735	COG0358	DNA primase activity
D1J60_RS11760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1J60_RS11765	COG2146	nitrite reductase [NAD(P)H] activity
D1J60_RS11765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1J60_RS11790	COG0574	Belongs to the PEP-utilizing enzyme family
D1J60_RS11790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1J60_RS11805	COG0667	Aldo Keto reductase
D1J60_RS11810	COG1309	transcriptional regulator
D1J60_RS11820	COG0423	glycine-tRNA ligase activity
D1J60_RS11825	COG0803	Belongs to the bacterial solute-binding protein 9 family
D1J60_RS11825	COG3443	Belongs to the bacterial solute-binding protein 9 family
D1J60_RS11830	COG1121	(ABC) transporter
D1J60_RS11835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1J60_RS11850	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D1J60_RS11855	COG1381	Involved in DNA repair and RecF pathway recombination
D1J60_RS11860	COG2233	PERMEase
D1J60_RS11870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1J60_RS11890	COG2226	methyltransferase
D1J60_RS11895	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D1J60_RS11925	COG2315	Protein conserved in bacteria
D1J60_RS11935	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D1J60_RS11945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1J60_RS11950	COG1234	tRNA 3'-trailer cleavage
D1J60_RS11955	COG0537	adenosine 5'-monophosphoramidase activity
D1J60_RS11970	COG0484	heat shock protein binding
D1J60_RS11975	COG1420	regulation of RNA biosynthetic process
D1J60_RS12005	COG0481	GTPase activity
D1J60_RS12010	COG0268	Binds directly to 16S ribosomal RNA
D1J60_RS12025	COG2353	YceI-like domain
D1J60_RS12035	COG1596	polysaccharide export
D1J60_RS12035	COG1555	photosystem II stabilization
D1J60_RS12040	COG1307	EDD domain protein, DegV family
D1J60_RS12050	COG0495	leucyl-tRNA aminoacylation
D1J60_RS12070	COG0588	phosphoglycerate mutase activity
D1J60_RS12075	COG0799	negative regulation of ribosome biogenesis
D1J60_RS12085	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D1J60_RS12090	COG0501	Belongs to the peptidase M48B family
D1J60_RS12105	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D1J60_RS12115	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D1J60_RS12125	COG0463	Glycosyl transferase, family 2
D1J60_RS12130	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D1J60_RS12135	COG0438	transferase activity, transferring glycosyl groups
D1J60_RS12145	COG1215	transferase activity, transferring glycosyl groups
D1J60_RS12150	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D1J60_RS12155	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D1J60_RS12160	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D1J60_RS12165	COG1530	ribonuclease E activity
D1J60_RS12190	COG0772	Belongs to the SEDS family
D1J60_RS12195	COG0768	penicillin binding
D1J60_RS12210	COG1077	Cell shape determining protein MreB Mrl
D1J60_RS12215	COG0105	UTP biosynthetic process
D1J60_RS12225	COG0285	dihydrofolate synthase activity
D1J60_RS12230	COG1077	Cell shape determining protein MreB Mrl
D1J60_RS12235	COG4585	Histidine kinase
D1J60_RS12240	COG0525	valine-tRNA ligase activity
D1J60_RS12250	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D1J60_RS12255	COG0740	serine-type endopeptidase activity
D1J60_RS12260	COG0740	serine-type endopeptidase activity
D1J60_RS12265	COG0544	peptidyl-prolyl cis-trans isomerase activity
D1J60_RS12300	COG0577	efflux transmembrane transporter activity
D1J60_RS12300	COG1136	(ABC) transporter
D1J60_RS12305	COG2208	phosphoserine phosphatase activity
D1J60_RS12310	COG4552	Acetyltransferase involved in intracellular survival and related
D1J60_RS12320	COG0698	ribose 5-phosphate isomerase
D1J60_RS12325	COG1113	amino acid transport
D1J60_RS12335	COG1113	amino acid transport
D1J60_RS12340	COG1113	amino acid transport
D1J60_RS12345	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D1J60_RS12350	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D1J60_RS12370	COG0346	lactoylglutathione lyase activity
D1J60_RS12385	COG2234	aminopeptidase activity
D1J60_RS12425	COG0697	spore germination
D1J60_RS12430	COG1846	Transcriptional regulator
D1J60_RS12450	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D1J60_RS12450	COG3291	Pkd domain containing protein
D1J60_RS12465	COG0668	transmembrane transport
D1J60_RS12480	COG1175	transmembrane transport
D1J60_RS12485	COG0395	ABC-type sugar transport system, permease component
D1J60_RS12490	COG1486	melibiose metabolic process
D1J60_RS12505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1J60_RS12540	COG2346	COG2346, Truncated hemoglobins
D1J60_RS12580	COG0629	single-stranded DNA binding
D1J60_RS12585	COG1116	anion transmembrane transporter activity
D1J60_RS12655	COG3962	Belongs to the TPP enzyme family
D1J60_RS12660	COG3718	enzyme involved in inositol metabolism
D1J60_RS12665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1J60_RS12675	COG0673	inositol 2-dehydrogenase activity
D1J60_RS12700	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D1J60_RS12725	COG1472	Belongs to the glycosyl hydrolase 3 family
D1J60_RS12750	COG0028	Belongs to the TPP enzyme family
D1J60_RS12775	COG1946	Acyl-CoA thioesterase
D1J60_RS12800	COG1309	transcriptional regulator
D1J60_RS12805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1J60_RS12820	COG1960	acyl-CoA dehydrogenase activity
D1J60_RS12830	COG2375	cellular response to nickel ion
D1J60_RS12835	COG0076	glutamate decarboxylase activity
D1J60_RS12840	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D1J60_RS12890	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1J60_RS12900	COG0589	response to stress
D1J60_RS12910	COG4977	sequence-specific DNA binding
D1J60_RS12915	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D1J60_RS12945	COG0745	RESPONSE REGULATOR receiver
D1J60_RS12955	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D1J60_RS12970	COG0406	alpha-ribazole phosphatase activity
D1J60_RS13005	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D1J60_RS13040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1J60_RS13055	COG0318	PFAM AMP-dependent synthetase and ligase
D1J60_RS13060	COG3397	chitin binding
D1J60_RS13130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1J60_RS13135	COG2188	Transcriptional regulator
D1J60_RS13145	COG1940	carbohydrate kinase activity
D1J60_RS13150	COG0673	inositol 2-dehydrogenase activity
D1J60_RS13160	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1J60_RS13165	COG0706	membrane insertase activity
D1J60_RS13175	COG3764	Sortase (surface protein transpeptidase)
D1J60_RS13205	COG2733	membrane
D1J60_RS13215	COG4555	ABC transporter
D1J60_RS13230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1J60_RS13270	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D1J60_RS13280	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D1J60_RS13285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1J60_RS13290	COG1263	PTS System
D1J60_RS13295	COG1263	PTS System
D1J60_RS13300	COG1234	tRNA 3'-trailer cleavage
D1J60_RS13310	COG3189	MarR family transcriptional regulator
D1J60_RS13335	COG1113	amino acid transport
D1J60_RS13345	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D1J60_RS13355	COG1335	isochorismatase
D1J60_RS13390	COG0277	FAD linked oxidase domain protein
D1J60_RS13400	COG3185	4-Hydroxyphenylpyruvate dioxygenase
D1J60_RS13445	COG3654	unkown
D1J60_RS13510	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D1J60_RS13520	COG1678	Uncharacterized ACR, COG1678
D1J60_RS13525	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D1J60_RS13530	COG0776	regulation of translation
D1J60_RS13545	COG3973	AAA domain
D1J60_RS13560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1J60_RS13575	COG0583	DNA-binding transcription factor activity
D1J60_RS13605	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D1J60_RS13610	COG0793	Belongs to the peptidase S41A family
D1J60_RS13620	COG2884	Cell division ATP-binding protein ftsE
D1J60_RS13630	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D1J60_RS13640	COG0515	serine threonine protein kinase
D1J60_RS13645	COG0515	serine threonine protein kinase
D1J60_RS13655	COG1653	transport
D1J60_RS13660	COG1175	transmembrane transport
D1J60_RS13665	COG0395	ABC-type sugar transport system, permease component
D1J60_RS13670	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D1J60_RS13685	COG1134	teichoic acid transport
D1J60_RS13685	COG1388	LysM domain
D1J60_RS13720	COG0653	protein targeting
D1J60_RS13735	COG2197	response regulator
D1J60_RS13740	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D1J60_RS13750	COG0823	Involved in the tonB-independent uptake of proteins
D1J60_RS13755	COG5000	phosphorelay sensor kinase activity
D1J60_RS13755	COG5002	protein histidine kinase activity
D1J60_RS13760	COG0745	RESPONSE REGULATOR receiver
D1J60_RS13780	COG0714	Associated with various cellular activities
D1J60_RS13825	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D1J60_RS13840	COG1482	cell wall glycoprotein biosynthetic process
D1J60_RS13850	COG2835	tetraacyldisaccharide 4'-kinase activity
D1J60_RS13855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1J60_RS13890	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D1J60_RS13895	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
D1J60_RS13895	COG0778	Nitroreductase
D1J60_RS13925	COG1316	TRANSCRIPTIONal
D1J60_RS13930	COG1316	TRANSCRIPTIONal
D1J60_RS13935	COG1316	TRANSCRIPTIONal
D1J60_RS13960	COG1316	TRANSCRIPTIONal
D1J60_RS13965	COG1216	Glycosyl transferase, family 2
D1J60_RS13970	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D1J60_RS13980	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D1J60_RS14015	COG2205	protein histidine kinase activity
D1J60_RS14020	COG0745	RESPONSE REGULATOR receiver
D1J60_RS14025	COG3104	oligopeptide transport
D1J60_RS14050	COG1228	amidohydrolase
D1J60_RS14065	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D1J60_RS14070	COG0019	diaminopimelate decarboxylase activity
D1J60_RS14090	COG2755	lipolytic protein G-D-S-L family
D1J60_RS14095	COG0183	Belongs to the thiolase family
D1J60_RS14125	COG1136	(ABC) transporter
D1J60_RS14130	COG0577	efflux transmembrane transporter activity
D1J60_RS14135	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D1J60_RS14140	COG1252	NADH dehydrogenase
D1J60_RS14160	COG0148	phosphopyruvate hydratase activity
D1J60_RS14175	COG2124	cytochrome p450
D1J60_RS14180	COG0543	2 iron, 2 sulfur cluster binding
D1J60_RS14205	COG2815	serine threonine protein kinase
D1J60_RS14205	COG0515	serine threonine protein kinase
D1J60_RS14250	COG0577	efflux transmembrane transporter activity
D1J60_RS14255	COG1136	(ABC) transporter
D1J60_RS14260	COG2814	Major facilitator Superfamily
D1J60_RS14285	COG0596	Alpha beta hydrolase
D1J60_RS14325	COG4585	Histidine kinase
D1J60_RS14335	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D1J60_RS14340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D1J60_RS14345	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D1J60_RS14350	COG0193	aminoacyl-tRNA hydrolase activity
D1J60_RS14355	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D1J60_RS14375	COG4106	trans-aconitate 2-methyltransferase activity
D1J60_RS14380	COG1846	Transcriptional regulator
D1J60_RS14385	COG2197	response regulator
D1J60_RS14410	COG0488	(ABC) transporter
D1J60_RS14420	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D1J60_RS14425	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D1J60_RS14430	COG3583	domain protein
D1J60_RS14430	COG3584	3D domain protein
D1J60_RS14435	COG0084	hydrolase, TatD family'
D1J60_RS14455	COG0768	penicillin binding
D1J60_RS14460	COG0442	prolyl-tRNA aminoacylation
D1J60_RS14470	COG1122	ATPase activity
D1J60_RS14480	COG0310	cobalt ion transport
D1J60_RS14490	COG2409	Drug exporters of the RND superfamily
D1J60_RS14500	COG4946	Tricorn protease homolog
D1J60_RS14500	COG0793	Belongs to the peptidase S41A family
D1J60_RS14510	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS14515	COG2267	carboxylic ester hydrolase activity
D1J60_RS14520	COG2072	flavoprotein involved in K transport
D1J60_RS14540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1J60_RS14560	COG0315	cyclic pyranopterin monophosphate synthase activity
D1J60_RS14560	COG0521	Mo-molybdopterin cofactor biosynthetic process
D1J60_RS14565	COG0315	cyclic pyranopterin monophosphate synthase activity
D1J60_RS14575	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D1J60_RS14580	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D1J60_RS14605	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D1J60_RS14620	COG1970	mechanosensitive ion channel activity
D1J60_RS14630	COG2223	nitrite transmembrane transporter activity
D1J60_RS14645	COG0437	4 iron, 4 sulfur cluster binding
D1J60_RS14650	COG0243	molybdopterin cofactor binding
D1J60_RS14660	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D1J60_RS14670	COG2223	nitrite transmembrane transporter activity
D1J60_RS14740	COG0438	transferase activity, transferring glycosyl groups
D1J60_RS14750	COG0728	peptidoglycan biosynthetic process
D1J60_RS14760	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D1J60_RS14765	COG0438	transferase activity, transferring glycosyl groups
D1J60_RS14830	COG0477	Major facilitator Superfamily
D1J60_RS14850	COG3384	dioxygenase
D1J60_RS14900	COG1686	Belongs to the peptidase S11 family
D1J60_RS14925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1J60_RS14935	COG2207	Transcriptional regulator
D1J60_RS14985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1J60_RS15020	COG2815	serine threonine protein kinase
D1J60_RS15020	COG0515	serine threonine protein kinase
D1J60_RS15040	COG1301	dicarboxylic acid transport
D1J60_RS15055	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D1J60_RS15065	COG0163	prenyltransferase activity
D1J60_RS15070	COG0705	Rhomboid family
D1J60_RS15090	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D1J60_RS15105	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D1J60_RS15120	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1J60_RS15125	COG1333	cytochrome c biogenesis protein
D1J60_RS15130	COG0785	Cytochrome C biogenesis protein
D1J60_RS15145	COG0406	alpha-ribazole phosphatase activity
D1J60_RS15150	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D1J60_RS15165	COG1733	regulation of RNA biosynthetic process
D1J60_RS15180	COG1742	UPF0060 membrane protein
D1J60_RS15190	COG0726	polysaccharide deacetylase
D1J60_RS15205	COG1690	Belongs to the RtcB family
D1J60_RS15225	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
D1J60_RS15230	COG0018	arginyl-trna synthetase
D1J60_RS15255	COG4115	mRNA cleavage
D1J60_RS15265	COG3629	intracellular signal transduction
D1J60_RS15265	COG3903	Transcriptional regulator
D1J60_RS15330	COG0113	porphobilinogen synthase activity
D1J60_RS15340	COG0181	hydroxymethylbilane synthase activity
D1J60_RS15345	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D1J60_RS15350	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
D1J60_RS15410	COG0123	including yeast histone deacetylase and acetoin utilization protein
D1J60_RS15415	COG2223	nitrite transmembrane transporter activity
D1J60_RS15420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1J60_RS15445	COG0180	Tryptophanyl-tRNA synthetase
D1J60_RS15450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D1J60_RS15460	COG0842	Transport permease protein
D1J60_RS15460	COG1129	ABC transporter
D1J60_RS15470	COG4991	sh3 domain protein
D1J60_RS15475	COG0515	serine threonine protein kinase
D1J60_RS15475	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1J60_RS15480	COG0129	dihydroxy-acid dehydratase activity
D1J60_RS15490	COG1082	Xylose isomerase domain protein TIM barrel
D1J60_RS15495	COG0248	Ppx GppA phosphatase
D1J60_RS15515	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
D1J60_RS15530	COG1194	a g-specific adenine glycosylase
D1J60_RS15535	COG1595	DNA-templated transcription, initiation
D1J60_RS15545	COG0745	RESPONSE REGULATOR receiver
D1J60_RS15550	COG2205	protein histidine kinase activity
D1J60_RS15560	COG0739	heme binding
D1J60_RS15585	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D1J60_RS15610	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D1J60_RS15620	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D1J60_RS15625	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D1J60_RS15650	COG0640	Transcriptional regulator
D1J60_RS15670	COG2197	response regulator
D1J60_RS15680	COG1674	ftsk spoiiie
D1J60_RS15755	COG0649	NAD binding
D1J60_RS15780	COG1732	Glycine betaine
D1J60_RS15785	COG1174	glycine betaine transport
D1J60_RS15790	COG1174	glycine betaine transport
D1J60_RS15810	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D1J60_RS15820	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D1J60_RS15840	COG0302	gtp cyclohydrolase
D1J60_RS15850	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D1J60_RS15855	COG0037	tRNA processing
D1J60_RS15865	COG2027	D-alanyl-D-alanine carboxypeptidase
D1J60_RS15870	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D1J60_RS15880	COG0586	Pfam SNARE associated Golgi protein
D1J60_RS15885	COG0789	Transcriptional regulator
D1J60_RS15890	COG2318	DinB family
D1J60_RS15895	COG1012	belongs to the aldehyde dehydrogenase family
D1J60_RS15935	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1J60_RS15935	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1J60_RS16030	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D1J60_RS16045	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D1J60_RS16050	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D1J60_RS16055	COG1754	DNA topoisomerase type I activity
D1J60_RS16055	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D1J60_RS16065	COG2890	protein-(glutamine-N5) methyltransferase activity
D1J60_RS16075	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D1J60_RS16085	COG1366	Belongs to the anti-sigma-factor antagonist family
D1J60_RS16090	COG1111	helicase
D1J60_RS16090	COG1205	dead DEAH box helicase
D1J60_RS16155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1J60_RS16160	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D1J60_RS16170	COG2267	carboxylic ester hydrolase activity
D1J60_RS16205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1J60_RS16230	COG0003	Pfam Anion-transporting ATPase
D1J60_RS16245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1J60_RS16255	COG1408	metallophosphoesterase
D1J60_RS16285	COG1309	transcriptional regulator
D1J60_RS16295	COG0402	S-adenosylhomocysteine deaminase activity
D1J60_RS16315	COG1595	DNA-templated transcription, initiation
D1J60_RS16335	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D1J60_RS16340	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D1J60_RS16360	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D1J60_RS16365	COG0693	protein deglycase activity
D1J60_RS16405	COG4585	Histidine kinase
D1J60_RS16410	COG2197	response regulator
D1J60_RS16420	COG2197	response regulator
D1J60_RS16435	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D1J60_RS16450	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D1J60_RS16485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1J60_RS16510	COG0191	fructose-bisphosphate aldolase activity
D1J60_RS16515	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D1J60_RS16530	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D1J60_RS16560	COG0542	response to heat
D1J60_RS16580	COG0789	Transcriptional regulator
D1J60_RS16585	COG0484	heat shock protein binding
D1J60_RS16590	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D1J60_RS16595	COG0443	Heat shock 70 kDa protein
D1J60_RS16605	COG2181	nitrate reductase activity
D1J60_RS16605	COG0247	lactate metabolic process
D1J60_RS16620	COG0717	Belongs to the dCTP deaminase family
D1J60_RS16700	COG1278	Cold shock
D1J60_RS16710	COG0513	Belongs to the DEAD box helicase family
D1J60_RS16725	COG4585	Histidine kinase
D1J60_RS16765	COG1278	Cold shock
D1J60_RS16815	COG2945	thiolester hydrolase activity
D1J60_RS16815	COG0596	Alpha beta hydrolase
D1J60_RS16850	COG4977	sequence-specific DNA binding
D1J60_RS16855	COG0596	Alpha beta hydrolase
D1J60_RS16860	COG3226	Transcriptional regulator
D1J60_RS16865	COG0667	Aldo Keto reductase
D1J60_RS16885	COG1191	sigma factor activity
D1J60_RS16895	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D1J60_RS16955	COG1289	transmembrane transporter activity
D1J60_RS16965	COG2205	protein histidine kinase activity
D1J60_RS16980	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D1J60_RS17015	COG0640	Transcriptional regulator
D1J60_RS17025	COG1960	acyl-CoA dehydrogenase activity
D1J60_RS17035	COG1362	aminopeptidase activity
D1J60_RS17065	COG2271	Major facilitator Superfamily
D1J60_RS17110	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D1J60_RS17140	COG0477	Major facilitator Superfamily
D1J60_RS17145	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D1J60_RS17165	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1J60_RS17170	COG0022	dehydrogenase e1 component
D1J60_RS17190	COG0515	serine threonine protein kinase
D1J60_RS17195	COG0515	serine threonine protein kinase
D1J60_RS17210	COG4591	ABC-type transport system involved in lipoprotein release permease component
D1J60_RS17210	COG1136	(ABC) transporter
D1J60_RS17235	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1J60_RS17240	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS17240	COG0604	alcohol dehydrogenase
D1J60_RS17240	COG3321	synthase
D1J60_RS17260	COG1522	sequence-specific DNA binding
D1J60_RS17265	COG1309	transcriptional regulator
D1J60_RS17270	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1J60_RS17295	COG3396	Phenylacetate-CoA oxygenase
D1J60_RS17300	COG3460	Phenylacetate-CoA oxygenase
D1J60_RS17305	COG3396	Phenylacetate-CoA oxygenase
D1J60_RS17310	COG2151	metal-sulfur cluster biosynthetic enzyme
D1J60_RS17315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1J60_RS17340	COG2197	response regulator
D1J60_RS17345	COG4585	Histidine kinase
D1J60_RS17355	COG1716	ATPase activity
D1J60_RS17360	COG1716	ATPase activity
D1J60_RS17385	COG0515	serine threonine protein kinase
D1J60_RS17390	COG3764	Sortase (surface protein transpeptidase)
D1J60_RS17395	COG3764	Sortase (surface protein transpeptidase)
D1J60_RS17405	COG3764	Sortase (surface protein transpeptidase)
D1J60_RS17435	COG1652	LysM domain
D1J60_RS17480	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1J60_RS17490	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
D1J60_RS17495	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D1J60_RS17500	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D1J60_RS17505	COG0592	DNA-directed DNA polymerase activity
D1J60_RS17515	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D1J60_RS17520	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D1J60_RS17525	COG0594	ribonuclease P activity
D1J60_RS17530	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D1J60_RS17535	COG0706	membrane insertase activity
D1J60_RS17545	COG0357	Ribosomal RNA small subunit methyltransferase G
D1J60_RS17550	COG1192	Involved in chromosome partitioning
D1J60_RS17565	COG3118	belongs to the thioredoxin family
D1J60_RS17570	COG0492	ferredoxin-NADP+ reductase activity
D1J60_RS17580	COG1595	DNA-templated transcription, initiation
D1J60_RS17585	COG2815	serine threonine protein kinase
D1J60_RS17585	COG0515	serine threonine protein kinase
D1J60_RS17600	COG0617	tRNA 3'-terminal CCA addition
D1J60_RS17620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1J60_RS17645	COG0360	Binds together with S18 to 16S ribosomal RNA
D1J60_RS17650	COG0629	single-stranded DNA binding
D1J60_RS17655	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D1J60_RS17660	COG0359	binds to the 23S rRNA
D1J60_RS17670	COG0305	Participates in initiation and elongation during chromosome replication
D1J60_RS17685	COG0456	acetyltransferase
D1J60_RS17705	COG0494	nUDIX hydrolase
D1J60_RS17715	COG0626	cystathionine gamma-synthase activity
D1J60_RS17720	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D1J60_RS17725	COG1950	PFAM Membrane protein of
D1J60_RS17730	COG0662	Cupin 2, conserved barrel domain protein
D1J60_RS17755	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D1J60_RS17770	COG1609	Transcriptional regulator
D1J60_RS17775	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1J60_RS17785	COG1271	oxidase subunit
D1J60_RS17790	COG1294	oxidase, subunit
D1J60_RS17795	COG4988	ABC transporter
D1J60_RS17805	COG0561	phosphatase activity
D1J60_RS17820	COG0326	Molecular chaperone. Has ATPase activity
D1J60_RS17825	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
D1J60_RS17835	COG0789	Transcriptional regulator
D1J60_RS17875	COG0561	phosphatase activity
D1J60_RS17880	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D1J60_RS17890	COG2837	iron assimilation
D1J60_RS17895	COG2372	response to copper ion
D1J60_RS17925	COG0006	proline dipeptidase activity
D1J60_RS17945	COG0653	protein targeting
D1J60_RS17960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1J60_RS17965	COG0583	DNA-binding transcription factor activity
D1J60_RS17975	COG2855	membrane
D1J60_RS18000	COG1960	acyl-CoA dehydrogenase activity
D1J60_RS18010	COG1960	acyl-CoA dehydrogenase activity
D1J60_RS18025	COG1595	DNA-templated transcription, initiation
D1J60_RS18030	COG0318	PFAM AMP-dependent synthetase and ligase
D1J60_RS18090	COG0745	RESPONSE REGULATOR receiver
D1J60_RS18095	COG2205	protein histidine kinase activity
D1J60_RS18100	COG1215	transferase activity, transferring glycosyl groups
D1J60_RS18105	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D1J60_RS18105	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D1J60_RS18130	COG1191	sigma factor activity
D1J60_RS18170	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D1J60_RS18185	COG0433	COG0433 Predicted ATPase
D1J60_RS18250	COG0151	Belongs to the GarS family
D1J60_RS18265	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D1J60_RS18275	COG2197	response regulator
D1J60_RS18280	COG3850	Histidine kinase
D1J60_RS18290	COG1131	(ABC) transporter
D1J60_RS18310	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1J60_RS18315	COG0047	phosphoribosylformylglycinamidine synthase activity
D1J60_RS18320	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1J60_RS18335	COG3119	arylsulfatase activity
D1J60_RS18345	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D1J60_RS18375	COG1643	Atp-dependent helicase
D1J60_RS18390	COG0785	Cytochrome C biogenesis protein
D1J60_RS18415	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D1J60_RS18420	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D1J60_RS18430	COG0513	Belongs to the DEAD box helicase family
D1J60_RS18450	COG1196	nuclear chromosome segregation
D1J60_RS18450	COG0739	heme binding
D1J60_RS18450	COG0741	lytic transglycosylase activity
D1J60_RS18460	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D1J60_RS18470	COG0579	oxidoreductase
D1J60_RS18500	COG1252	NADH dehydrogenase
D1J60_RS18620	COG1357	PFAM Pentapeptide repeats (8 copies)
D1J60_RS18625	COG1280	lysine exporter protein (LysE YggA)
D1J60_RS18645	COG0671	phosphoesterase, PA-phosphatase related
D1J60_RS18665	COG1937	Protein conserved in bacteria
D1J60_RS18675	COG0306	phosphate transporter
D1J60_RS18680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D1J60_RS18705	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D1J60_RS18710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1J60_RS18725	COG0823	Involved in the tonB-independent uptake of proteins
D1J60_RS18730	COG1309	transcriptional regulator
D1J60_RS18735	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D1J60_RS18740	COG0737	Belongs to the 5'-nucleotidase family
D1J60_RS18745	COG0456	acetyltransferase
D1J60_RS18765	COG1609	Transcriptional regulator
D1J60_RS18770	COG0745	RESPONSE REGULATOR receiver
D1J60_RS18790	COG2897	thiosulfate sulfurtransferase activity
D1J60_RS18820	COG3485	protocatechuate 3,4-dioxygenase
D1J60_RS18835	COG1490	D-aminoacyl-tRNA deacylase activity
D1J60_RS18850	COG4552	Acetyltransferase involved in intracellular survival and related
D1J60_RS18855	COG2890	protein-(glutamine-N5) methyltransferase activity
D1J60_RS18875	COG1733	regulation of RNA biosynthetic process
D1J60_RS18905	COG0791	NLP P60 protein
D1J60_RS18915	COG0438	transferase activity, transferring glycosyl groups
D1J60_RS18930	COG0588	phosphoglycerate mutase activity
D1J60_RS18985	COG5002	protein histidine kinase activity
D1J60_RS19005	COG1329	Transcriptional regulator
D1J60_RS19010	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D1J60_RS19015	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D1J60_RS19020	COG0215	cysteine-tRNA ligase activity
D1J60_RS19035	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D1J60_RS19045	COG3842	ATPase activity
D1J60_RS19060	COG0456	acetyltransferase
D1J60_RS19070	COG0515	serine threonine protein kinase
D1J60_RS19070	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1J60_RS19145	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D1J60_RS19165	COG0561	phosphatase activity
D1J60_RS19165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1J60_RS19185	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
D1J60_RS19190	COG0463	Glycosyl transferase, family 2
D1J60_RS19225	COG0135	phosphoribosylanthranilate isomerase activity
D1J60_RS19245	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D1J60_RS19285	COG3973	AAA domain
D1J60_RS19295	COG1061	Type III restriction enzyme res subunit
D1J60_RS19350	COG1278	Cold shock
D1J60_RS19355	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
D1J60_RS19360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D1J60_RS19370	COG2814	Major facilitator Superfamily
D1J60_RS19380	COG1595	DNA-templated transcription, initiation
D1J60_RS19400	COG0667	Aldo Keto reductase
D1J60_RS19410	COG1834	amidinotransferase
D1J60_RS19435	COG2252	PERMEase
D1J60_RS19445	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D1J60_RS19465	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D1J60_RS19470	COG0277	FAD linked oxidase domain protein
D1J60_RS19470	COG0247	lactate metabolic process
D1J60_RS19475	COG5006	permease, DMT superfamily
D1J60_RS19490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D1J60_RS19515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1J60_RS19530	COG1024	Enoyl-CoA hydratase
D1J60_RS19535	COG1309	transcriptional regulator
D1J60_RS19545	COG0259	pyridoxamine-phosphate oxidase activity
D1J60_RS19555	COG4821	SIS domain
D1J60_RS19565	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D1J60_RS19605	COG1131	(ABC) transporter
D1J60_RS19670	COG0318	PFAM AMP-dependent synthetase and ligase
D1J60_RS19680	COG1960	acyl-CoA dehydrogenase activity
D1J60_RS19685	COG1960	acyl-CoA dehydrogenase activity
D1J60_RS19710	COG2124	cytochrome p450
D1J60_RS19720	COG1309	transcriptional regulator
D1J60_RS19800	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS19805	COG1960	acyl-CoA dehydrogenase activity
D1J60_RS19845	COG1024	Enoyl-CoA hydratase
D1J60_RS19860	COG2072	flavoprotein involved in K transport
D1J60_RS19905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1J60_RS19915	COG2226	methyltransferase
D1J60_RS19920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1J60_RS19935	COG1131	(ABC) transporter
D1J60_RS19950	COG0515	serine threonine protein kinase
D1J60_RS19970	COG0384	phenazine biosynthesis protein PhzF
D1J60_RS19995	COG0494	nUDIX hydrolase
D1J60_RS20005	COG0596	Alpha beta hydrolase
D1J60_RS20020	COG3467	pyridoxamine 5'-phosphate
D1J60_RS20025	COG0183	Belongs to the thiolase family
D1J60_RS20030	COG1960	acyl-CoA dehydrogenase activity
D1J60_RS20040	COG1309	transcriptional regulator
D1J60_RS20050	COG0515	serine threonine protein kinase
D1J60_RS20050	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1J60_RS20065	COG1024	Enoyl-CoA hydratase
D1J60_RS20090	COG4409	exo-alpha-(2->6)-sialidase activity
D1J60_RS20150	COG0583	DNA-binding transcription factor activity
D1J60_RS20155	COG5006	permease, DMT superfamily
D1J60_RS20165	COG0494	nUDIX hydrolase
D1J60_RS20235	COG0346	lactoylglutathione lyase activity
D1J60_RS20330	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D1J60_RS20360	COG1278	Cold shock
D1J60_RS20365	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
D1J60_RS20375	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D1J60_RS20390	COG2226	methyltransferase
D1J60_RS20395	COG2066	Belongs to the glutaminase family
D1J60_RS20410	COG0791	NLP P60 protein
D1J60_RS20420	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1J60_RS20425	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1J60_RS20430	COG0649	NAD binding
D1J60_RS20440	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D1J60_RS20445	COG1034	ATP synthesis coupled electron transport
D1J60_RS20450	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D1J60_RS20455	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1J60_RS20460	COG0839	Belongs to the complex I subunit 6 family
D1J60_RS20465	COG0713	ATP synthesis coupled electron transport
D1J60_RS20470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D1J60_RS20480	COG1007	ATP synthesis coupled electron transport
D1J60_RS20505	COG2936	dipeptidyl-peptidase activity
D1J60_RS20510	COG0142	geranyltranstransferase activity
D1J60_RS20545	COG0702	epimerase
D1J60_RS20550	COG1733	regulation of RNA biosynthetic process
D1J60_RS20555	COG1013	pyruvate-flavodoxin oxidoreductase activity
D1J60_RS20560	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D1J60_RS20560	COG0674	pyruvate-flavodoxin oxidoreductase activity
D1J60_RS20580	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1J60_RS20585	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1J60_RS20590	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1J60_RS20595	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D1J60_RS20600	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1J60_RS20605	COG0839	Belongs to the complex I subunit 6 family
D1J60_RS20610	COG0713	ATP synthesis coupled electron transport
D1J60_RS20625	COG1007	ATP synthesis coupled electron transport
D1J60_RS20630	COG0501	Belongs to the peptidase M48B family
D1J60_RS20635	COG3304	Inner membrane component domain
D1J60_RS20655	COG0659	secondary active sulfate transmembrane transporter activity
D1J60_RS20660	COG1666	GTP binding
D1J60_RS20680	COG0702	epimerase
D1J60_RS20700	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D1J60_RS20705	COG2030	dehydratase
D1J60_RS20720	COG0477	Major facilitator Superfamily
D1J60_RS20730	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D1J60_RS20740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1J60_RS20745	COG0436	Aminotransferase
D1J60_RS20755	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D1J60_RS20780	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D1J60_RS20785	COG0222	ribosome binding
D1J60_RS20795	COG0085	RNA polymerase activity
D1J60_RS20800	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D1J60_RS20835	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D1J60_RS20840	COG0049	tRNA binding
D1J60_RS20845	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1J60_RS20850	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1J60_RS20860	COG0051	transcription antitermination factor activity, RNA binding
D1J60_RS20865	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D1J60_RS20870	COG0088	Forms part of the polypeptide exit tunnel
D1J60_RS20875	COG0089	rRNA binding
D1J60_RS20880	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D1J60_RS20885	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D1J60_RS20890	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D1J60_RS20895	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D1J60_RS20900	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D1J60_RS20905	COG0255	Belongs to the universal ribosomal protein uL29 family
D1J60_RS20910	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D1J60_RS20915	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D1J60_RS20920	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D1J60_RS20925	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D1J60_RS20930	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D1J60_RS20940	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D1J60_RS20945	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D1J60_RS20950	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D1J60_RS20955	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D1J60_RS20960	COG1841	ribosomal large subunit assembly
D1J60_RS20965	COG0200	Binds to the 23S rRNA
D1J60_RS20970	COG0201	protein transport
D1J60_RS20975	COG0563	adenylate kinase activity
D1J60_RS20985	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D1J60_RS20990	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D1J60_RS20995	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D1J60_RS21000	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D1J60_RS21005	COG0202	RNA polymerase activity
D1J60_RS21010	COG0203	ribosomal protein L17
D1J60_RS21015	COG0101	tRNA pseudouridine synthase activity
D1J60_RS21020	COG0488	(ABC) transporter
D1J60_RS21030	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D1J60_RS21035	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D1J60_RS21040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1J60_RS21045	COG1072	(Pantothenic acid kinase))
D1J60_RS21060	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1J60_RS21065	COG0736	holo-[acyl-carrier-protein] synthase activity
D1J60_RS21080	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D1J60_RS21085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1J60_RS21090	COG0802	atpase or kinase
D1J60_RS21115	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D1J60_RS21135	COG0726	polysaccharide deacetylase
D1J60_RS21140	COG0726	polysaccharide deacetylase
D1J60_RS21145	COG1595	DNA-templated transcription, initiation
D1J60_RS21150	COG1252	NADH dehydrogenase
D1J60_RS21170	COG1316	TRANSCRIPTIONal
D1J60_RS21175	COG2205	protein histidine kinase activity
D1J60_RS21180	COG0745	RESPONSE REGULATOR receiver
D1J60_RS21185	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D1J60_RS21200	COG4221	oxidoreductase activity
D1J60_RS21205	COG0583	DNA-binding transcription factor activity
D1J60_RS21220	COG1595	DNA-templated transcription, initiation
D1J60_RS21230	COG0516	GMP reductase activity
D1J60_RS21260	COG0515	serine threonine protein kinase
D1J60_RS21265	COG1012	belongs to the aldehyde dehydrogenase family
D1J60_RS21285	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D1J60_RS21285	COG0519	Catalyzes the synthesis of GMP from XMP
D1J60_RS21320	COG2197	response regulator
D1J60_RS21325	COG2382	esterase
D1J60_RS21325	COG3693	PFAM glycoside hydrolase, family 10
D1J60_RS21355	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1J60_RS21355	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1J60_RS21370	COG0714	Associated with various cellular activities
D1J60_RS21380	COG3552	Protein containing von Willebrand factor type A (VWA) domain
D1J60_RS21385	COG0045	succinate-CoA ligase (ADP-forming) activity
D1J60_RS21425	COG0138	bifunctional purine biosynthesis protein purh
D1J60_RS21435	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D1J60_RS21455	COG0039	L-malate dehydrogenase activity
D1J60_RS21475	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1J60_RS21480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1J60_RS21515	COG0754	glutathionylspermidine amidase activity
D1J60_RS21525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1J60_RS21530	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1J60_RS21535	COG0180	Tryptophanyl-tRNA synthetase
D1J60_RS21545	COG1295	ribonuclease BN
D1J60_RS21550	COG1686	Belongs to the peptidase S11 family
D1J60_RS21560	COG1408	metallophosphoesterase
D1J60_RS21565	COG1846	Transcriptional regulator
D1J60_RS21575	COG1309	transcriptional regulator
D1J60_RS21585	COG1053	succinate dehydrogenase
D1J60_RS21595	COG2009	succinate dehydrogenase
D1J60_RS21605	COG1595	DNA-templated transcription, initiation
D1J60_RS21620	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1J60_RS21620	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1J60_RS21635	COG1216	Glycosyl transferase, family 2
D1J60_RS21655	COG2089	acid synthase
D1J60_RS21665	COG1473	amidohydrolase
D1J60_RS21665	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D1J60_RS21670	COG1744	ABC transporter substrate-binding protein PnrA-like
D1J60_RS21675	COG3845	ABC transporter
D1J60_RS21680	COG4603	Belongs to the binding-protein-dependent transport system permease family
D1J60_RS21685	COG1079	Belongs to the binding-protein-dependent transport system permease family
D1J60_RS21715	COG2814	Major facilitator Superfamily
D1J60_RS21720	COG0583	DNA-binding transcription factor activity
D1J60_RS21745	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1J60_RS21780	COG1012	belongs to the aldehyde dehydrogenase family
D1J60_RS21785	COG1012	belongs to the aldehyde dehydrogenase family
D1J60_RS21800	COG1595	DNA-templated transcription, initiation
D1J60_RS21805	COG0745	RESPONSE REGULATOR receiver
D1J60_RS21810	COG2205	protein histidine kinase activity
D1J60_RS21830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1J60_RS21855	COG4770	biotin carboxylase activity
D1J60_RS21865	COG0424	maF-like protein
D1J60_RS21875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1J60_RS21890	COG1024	Enoyl-CoA hydratase
D1J60_RS21900	COG2986	histidine ammonia-lyase
D1J60_RS21915	COG1376	ErfK ybiS ycfS ynhG family protein
D1J60_RS21930	COG1064	alcohol dehydrogenase
D1J60_RS21935	COG0789	Transcriptional regulator
D1J60_RS21945	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1J60_RS21975	COG1595	DNA-templated transcription, initiation
D1J60_RS21985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D1J60_RS21990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D1J60_RS22010	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D1J60_RS22035	COG1331	Highly conserved protein containing a thioredoxin domain
D1J60_RS22070	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
D1J60_RS22085	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1J60_RS22095	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D1J60_RS22100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1J60_RS22105	COG0736	holo-[acyl-carrier-protein] synthase activity
D1J60_RS22110	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS22115	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1J60_RS22120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1J60_RS22125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1J60_RS22130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1J60_RS22135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1J60_RS22140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1J60_RS22150	COG0667	Aldo Keto reductase
D1J60_RS22170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1J60_RS22180	COG2197	response regulator
D1J60_RS22185	COG1233	COG1233 Phytoene dehydrogenase and related
D1J60_RS22195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1J60_RS22200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1J60_RS22215	COG1011	Hydrolase
D1J60_RS22310	COG0436	Aminotransferase
D1J60_RS22355	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
D1J60_RS22390	COG2894	cell division
D1J60_RS22420	COG4585	Histidine kinase
D1J60_RS22445	COG2885	chlorophyll binding
D1J60_RS22515	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D1J60_RS22525	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D1J60_RS22540	COG0726	polysaccharide deacetylase
D1J60_RS22580	COG0667	Aldo Keto reductase
D1J60_RS22585	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D1J60_RS22590	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D1J60_RS22610	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1J60_RS22615	COG0450	alkyl hydroperoxide reductase
D1J60_RS22655	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D1J60_RS22665	COG3557	Belongs to the UPF0374 family
D1J60_RS22670	COG0114	fumarate hydratase activity
D1J60_RS22685	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D1J60_RS22685	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D1J60_RS22710	COG0778	Nitroreductase
D1J60_RS22715	COG1722	exodeoxyribonuclease VII activity
D1J60_RS22720	COG1570	exodeoxyribonuclease VII activity
D1J60_RS22725	COG1113	amino acid transport
D1J60_RS22730	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D1J60_RS22745	COG0012	GTP binding
D1J60_RS22765	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D1J60_RS22800	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
D1J60_RS22810	COG2226	methyltransferase
D1J60_RS22845	COG0515	serine threonine protein kinase
D1J60_RS22900	COG0277	FAD linked oxidase domain protein
D1J60_RS22900	COG0247	lactate metabolic process
D1J60_RS22905	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1J60_RS22920	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1J60_RS22950	COG0697	spore germination
D1J60_RS23000	COG1842	Phage shock protein A
D1J60_RS23010	COG2815	serine threonine protein kinase
D1J60_RS23010	COG0515	serine threonine protein kinase
D1J60_RS23020	COG1053	succinate dehydrogenase
D1J60_RS23040	COG1217	gtp-binding protein TYPA
D1J60_RS23050	COG0601	transmembrane transport
D1J60_RS23055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1J60_RS23060	COG0444	Belongs to the ABC transporter superfamily
D1J60_RS23065	COG4608	Belongs to the ABC transporter superfamily
D1J60_RS23075	COG4166	transmembrane transport
D1J60_RS23080	COG0601	transmembrane transport
D1J60_RS23085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1J60_RS23095	COG4608	Belongs to the ABC transporter superfamily
D1J60_RS23105	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D1J60_RS23125	COG1131	(ABC) transporter
D1J60_RS23135	COG4585	Histidine kinase
D1J60_RS23140	COG2197	response regulator
D1J60_RS23175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1J60_RS23180	COG1611	Belongs to the LOG family
D1J60_RS23195	COG0519	Catalyzes the synthesis of GMP from XMP
D1J60_RS23200	COG1024	Enoyl-CoA hydratase
D1J60_RS23215	COG1595	DNA-templated transcription, initiation
D1J60_RS23225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1J60_RS23230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1J60_RS23265	COG0598	Magnesium transport protein CorA
D1J60_RS23315	COG2095	MarC family integral membrane protein
D1J60_RS23375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1J60_RS23420	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D1J60_RS23425	COG0535	radical SAM domain protein
D1J60_RS23440	COG1140	nitrate reductase beta subunit
D1J60_RS23470	COG0210	DNA helicase
D1J60_RS23515	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D1J60_RS23570	COG3480	Lon protease (S16) C-terminal proteolytic domain
D1J60_RS23580	COG1615	UPF0182 protein
D1J60_RS23605	COG0753	catalase activity
D1J60_RS23615	COG0483	inositol monophosphate 1-phosphatase activity
D1J60_RS23625	COG2076	Multidrug Resistance protein
D1J60_RS23630	COG1162	GTPase activity
D1J60_RS23635	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D1J60_RS23645	COG2135	peptidase activity
D1J60_RS23655	COG1595	DNA-templated transcription, initiation
D1J60_RS23660	COG5662	AntiSigma factor
D1J60_RS23665	COG2199	diguanylate cyclase activity
D1J60_RS23665	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D1J60_RS23680	COG0242	peptide deformylase activity
D1J60_RS23690	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D1J60_RS23690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1J60_RS23710	COG1966	Carbon starvation protein
D1J60_RS23715	COG2188	Transcriptional regulator
D1J60_RS23720	COG2182	Extracellular solute-binding protein
D1J60_RS23725	COG1175	transmembrane transport
D1J60_RS23730	COG0395	ABC-type sugar transport system, permease component
D1J60_RS23735	COG1472	Belongs to the glycosyl hydrolase 3 family
D1J60_RS23740	COG0363	glucosamine-6-phosphate deaminase activity
D1J60_RS23745	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS23750	COG1309	transcriptional regulator
D1J60_RS23765	COG1597	lipid kinase activity
D1J60_RS23795	COG2515	1-aminocyclopropane-1-carboxylate deaminase
D1J60_RS23805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1J60_RS23805	COG1017	nitric oxide dioxygenase activity
D1J60_RS23810	COG1959	2 iron, 2 sulfur cluster binding
D1J60_RS23815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1J60_RS23820	COG0142	geranyltranstransferase activity
D1J60_RS23840	COG5640	endopeptidase activity
D1J60_RS23870	COG0604	alcohol dehydrogenase
D1J60_RS23885	COG0765	amino acid transport
D1J60_RS23890	COG1126	abc transporter atp-binding protein
D1J60_RS23895	COG4106	trans-aconitate 2-methyltransferase activity
D1J60_RS23955	COG0567	Dehydrogenase, E1 component
D1J60_RS23955	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1J60_RS23960	COG2205	protein histidine kinase activity
D1J60_RS23965	COG0745	RESPONSE REGULATOR receiver
D1J60_RS23985	COG2897	thiosulfate sulfurtransferase activity
D1J60_RS24000	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D1J60_RS24015	COG5002	protein histidine kinase activity
D1J60_RS24040	COG3883	PFAM NLP P60 protein
D1J60_RS24040	COG0791	NLP P60 protein
D1J60_RS24060	COG1247	-acetyltransferase
D1J60_RS24075	COG0772	Belongs to the SEDS family
D1J60_RS24080	COG0768	penicillin binding
D1J60_RS24095	COG1309	transcriptional regulator
D1J60_RS24105	COG2205	protein histidine kinase activity
D1J60_RS24125	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D1J60_RS24130	COG1793	dna ligase
D1J60_RS24130	COG3285	dna ligase
D1J60_RS24135	COG1793	dna ligase
D1J60_RS24135	COG3285	dna ligase
D1J60_RS24145	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D1J60_RS24145	COG3608	succinylglutamate desuccinylase aspartoacylase
D1J60_RS24160	COG0745	RESPONSE REGULATOR receiver
D1J60_RS24165	COG0018	arginyl-trna synthetase
D1J60_RS24165	COG0018	arginyl-trna synthetase
D1J60_RS24170	COG0019	diaminopimelate decarboxylase activity
D1J60_RS24175	COG0460	homoserine dehydrogenase
D1J60_RS24180	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D1J60_RS24185	COG0083	homoserine kinase activity
D1J60_RS24200	COG0254	rRNA binding
D1J60_RS24205	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D1J60_RS24210	COG2890	protein-(glutamine-N5) methyltransferase activity
D1J60_RS24220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D1J60_RS24225	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1J60_RS24245	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D1J60_RS24250	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D1J60_RS24255	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D1J60_RS24260	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D1J60_RS24265	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D1J60_RS24270	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D1J60_RS24275	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D1J60_RS24290	COG2197	response regulator
D1J60_RS24295	COG4585	Histidine kinase
D1J60_RS24310	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1J60_RS24330	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
D1J60_RS24385	COG0183	Belongs to the thiolase family
D1J60_RS24465	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1J60_RS24465	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1J60_RS24515	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D1J60_RS24520	COG0857	belongs to the CobB CobQ family
D1J60_RS24520	COG0280	phosphate acetyltransferase
D1J60_RS24525	COG0205	6-phosphofructokinase activity
D1J60_RS24535	COG0789	Transcriptional regulator
D1J60_RS24560	COG0366	Alpha amylase catalytic
D1J60_RS24570	COG0058	SHG alpha-glucan phosphorylase activity
D1J60_RS24595	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D1J60_RS24600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1J60_RS24605	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D1J60_RS24650	COG0739	heme binding
D1J60_RS24660	COG0489	protein tyrosine kinase activity
D1J60_RS24665	COG0297	glycogen (starch) synthase activity
D1J60_RS24730	COG1122	ATPase activity
D1J60_RS24740	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
D1J60_RS24745	COG0310	cobalt ion transport
D1J60_RS24765	COG1760	l-serine dehydratase
D1J60_RS24770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1J60_RS24775	COG0509	glycine decarboxylation via glycine cleavage system
D1J60_RS24780	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1J60_RS24800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1J60_RS24805	COG0747	negative chemotaxis
D1J60_RS24810	COG0601	transmembrane transport
D1J60_RS24815	COG0444	Belongs to the ABC transporter superfamily
D1J60_RS24820	COG4608	Belongs to the ABC transporter superfamily
D1J60_RS24825	COG2860	membrane
D1J60_RS24845	COG0482	sulfurtransferase activity
D1J60_RS24855	COG4977	sequence-specific DNA binding
D1J60_RS24875	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D1J60_RS24885	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1J60_RS24890	COG0154	amidase activity
D1J60_RS24900	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1J60_RS24915	COG2267	carboxylic ester hydrolase activity
D1J60_RS24930	COG1132	(ABC) transporter
D1J60_RS24930	COG2375	cellular response to nickel ion
D1J60_RS24935	COG2318	DinB family
D1J60_RS24950	COG2409	Drug exporters of the RND superfamily
D1J60_RS24955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1J60_RS24970	COG2197	response regulator
D1J60_RS24980	COG2133	pyrroloquinoline quinone binding
D1J60_RS24985	COG0667	Aldo Keto reductase
D1J60_RS25005	COG0440	acetolactate synthase activity
D1J60_RS25010	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D1J60_RS25015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1J60_RS25020	COG0477	Major facilitator Superfamily
D1J60_RS25035	COG0506	proline dehydrogenase activity
D1J60_RS25040	COG1012	belongs to the aldehyde dehydrogenase family
D1J60_RS25045	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
D1J60_RS25045	COG0778	Nitroreductase
D1J60_RS25060	COG3511	phospholipase C
D1J60_RS25070	COG0583	DNA-binding transcription factor activity
D1J60_RS25075	COG0473	3-isopropylmalate dehydrogenase activity
D1J60_RS25080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1J60_RS25090	COG0831	urea catabolic process
D1J60_RS25090	COG0832	Belongs to the urease beta subunit family
D1J60_RS25095	COG0804	urea catabolic process
D1J60_RS25100	COG2957	Belongs to the agmatine deiminase family
D1J60_RS25105	COG1309	transcriptional regulator
D1J60_RS25115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1J60_RS25130	COG2353	YceI-like domain
D1J60_RS25135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1J60_RS25155	COG2018	Roadblock/LC7 domain
D1J60_RS25175	COG2018	Roadblock/LC7 domain
D1J60_RS25180	COG5002	protein histidine kinase activity
D1J60_RS25190	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1J60_RS25195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1J60_RS25200	COG1011	Hydrolase
D1J60_RS25235	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D1J60_RS25240	COG0066	3-isopropylmalate dehydratase activity
D1J60_RS25250	COG0776	regulation of translation
D1J60_RS25255	COG1920	GTP binding
D1J60_RS25265	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D1J60_RS25270	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1J60_RS25290	COG0351	phosphomethylpyrimidine kinase
D1J60_RS25295	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D1J60_RS25300	COG1461	Dihydroxyacetone kinase
D1J60_RS25310	COG0742	ribosomal rna small subunit methyltransferase
D1J60_RS25315	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D1J60_RS25330	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D1J60_RS25335	COG0571	ribonuclease III activity
D1J60_RS25340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D1J60_RS25345	COG1733	regulation of RNA biosynthetic process
D1J60_RS25355	COG2340	Cysteine-rich secretory protein family
D1J60_RS25360	COG1254	Belongs to the acylphosphatase family
D1J60_RS25370	COG1196	nuclear chromosome segregation
D1J60_RS25375	COG0477	Major facilitator Superfamily
D1J60_RS25415	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D1J60_RS25425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1J60_RS25435	COG0442	prolyl-tRNA aminoacylation
D1J60_RS25445	COG0228	four-way junction DNA binding
D1J60_RS25450	COG1837	Belongs to the UPF0109 family
D1J60_RS25455	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D1J60_RS25460	COG0336	Belongs to the RNA methyltransferase TrmD family
D1J60_RS25465	COG0335	large ribosomal subunit rRNA binding
D1J60_RS25500	COG0792	nuclease activity
D1J60_RS25525	COG0535	radical SAM domain protein
D1J60_RS25775	COG2176	DNA-directed DNA polymerase activity
D1J60_RS25775	COG5002	protein histidine kinase activity
D1J60_RS25860	COG1191	sigma factor activity
D1J60_RS25875	COG0052	Belongs to the universal ribosomal protein uS2 family
D1J60_RS25880	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D1J60_RS25885	COG0528	UMP kinase activity
D1J60_RS25890	COG0233	cytoplasmic translational termination
D1J60_RS25895	COG0575	Belongs to the CDS family
D1J60_RS25900	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D1J60_RS25915	COG3842	ATPase activity
D1J60_RS25925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1J60_RS25960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1J60_RS25970	COG1012	belongs to the aldehyde dehydrogenase family
D1J60_RS25985	COG2197	response regulator
D1J60_RS25990	COG4585	Histidine kinase
D1J60_RS26000	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1J60_RS26025	COG1012	belongs to the aldehyde dehydrogenase family
D1J60_RS26030	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D1J60_RS26035	COG3842	ATPase activity
D1J60_RS26040	COG1176	ABC-type spermidine putrescine transport system, permease component I
D1J60_RS26045	COG1177	transmembrane transport
D1J60_RS26050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1J60_RS26080	COG1012	belongs to the aldehyde dehydrogenase family
D1J60_RS26095	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D1J60_RS26100	COG0750	zinc metalloprotease
D1J60_RS26105	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D1J60_RS26120	COG0442	prolyl-tRNA aminoacylation
D1J60_RS26125	COG0330	HflC and HflK could
D1J60_RS26145	COG0779	Required for maturation of 30S ribosomal subunits
D1J60_RS26160	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D1J60_RS26170	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D1J60_RS26175	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D1J60_RS26190	COG0455	bacterial-type flagellum organization
D1J60_RS26210	COG1404	Belongs to the peptidase S8 family
D1J60_RS26230	COG1674	ftsk spoiiie
D1J60_RS26240	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D1J60_RS26245	COG1185	polyribonucleotide nucleotidyltransferase activity
D1J60_RS26250	COG0612	Peptidase, M16
D1J60_RS26255	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D1J60_RS26275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1J60_RS26280	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D1J60_RS26310	COG2770	Histidine kinase
D1J60_RS26310	COG2208	phosphoserine phosphatase activity
D1J60_RS26315	COG3850	Histidine kinase
D1J60_RS26315	COG2205	protein histidine kinase activity
D1J60_RS26315	COG3437	response regulator, receiver
D1J60_RS26315	COG4999	Histidine kinase
D1J60_RS26325	COG1674	ftsk spoiiie
D1J60_RS26335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1J60_RS26345	COG1058	Belongs to the CinA family
D1J60_RS26345	COG1546	Belongs to the CinA family
D1J60_RS26350	COG1396	sequence-specific DNA binding
D1J60_RS26360	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS26365	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D1J60_RS26375	COG1201	RNA secondary structure unwinding
D1J60_RS26380	COG1917	Cupin 2, conserved barrel domain protein
D1J60_RS26380	COG2207	Transcriptional regulator
D1J60_RS26425	COG2197	response regulator
D1J60_RS26430	COG4585	Histidine kinase
D1J60_RS26455	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D1J60_RS26485	COG0765	amino acid transport
D1J60_RS26490	COG0765	amino acid transport
D1J60_RS26495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1J60_RS26500	COG1126	abc transporter atp-binding protein
D1J60_RS26510	COG2205	protein histidine kinase activity
D1J60_RS26535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1J60_RS26555	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D1J60_RS26565	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D1J60_RS26570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1J60_RS26580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D1J60_RS26620	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D1J60_RS26625	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D1J60_RS26630	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1J60_RS26665	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D1J60_RS26710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1J60_RS26735	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1J60_RS26740	COG4565	transcriptional regulatory protein
D1J60_RS26745	COG3290	protein histidine kinase activity
D1J60_RS26750	COG0372	Belongs to the citrate synthase family
D1J60_RS26755	COG0372	Belongs to the citrate synthase family
D1J60_RS26770	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1J60_RS26775	COG0612	Peptidase, M16
D1J60_RS26790	COG1802	Transcriptional regulator
D1J60_RS26795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1J60_RS26800	COG1042	CoA-binding domain protein
D1J60_RS26800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1J60_RS26800	COG0045	succinate-CoA ligase (ADP-forming) activity
D1J60_RS26815	COG1435	thymidine kinase activity
D1J60_RS26870	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D1J60_RS26880	COG0745	RESPONSE REGULATOR receiver
D1J60_RS26885	COG2205	protein histidine kinase activity
D1J60_RS26910	COG0756	dUTP diphosphatase activity
D1J60_RS26945	COG0569	domain protein
D1J60_RS26950	COG0531	amino acid
D1J60_RS26955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D1J60_RS26970	COG0395	ABC-type sugar transport system, permease component
D1J60_RS26975	COG1175	transmembrane transport
D1J60_RS26985	COG1609	Transcriptional regulator
D1J60_RS27000	COG2217	Heavy metal translocating P-type atpase
D1J60_RS27020	COG3903	Transcriptional regulator
D1J60_RS27020	COG3629	intracellular signal transduction
D1J60_RS27040	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D1J60_RS27050	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D1J60_RS27055	COG0475	glutathione-regulated potassium exporter activity
D1J60_RS27070	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D1J60_RS27075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1J60_RS27115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1J60_RS27125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D1J60_RS27175	COG2091	lysine biosynthetic process via aminoadipic acid
D1J60_RS27185	COG0577	efflux transmembrane transporter activity
D1J60_RS27185	COG1136	(ABC) transporter
D1J60_RS27195	COG2175	clavaminate synthase activity
D1J60_RS27200	COG2091	lysine biosynthetic process via aminoadipic acid
D1J60_RS27210	COG3903	Transcriptional regulator
D1J60_RS27210	COG3629	intracellular signal transduction
D1J60_RS27220	COG0252	asparaginase activity
D1J60_RS27250	COG0431	NADPH-dependent FMN reductase
D1J60_RS27270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1J60_RS27290	COG1799	cell septum assembly
D1J60_RS27330	COG2040	homocysteine
D1J60_RS27345	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D1J60_RS27360	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D1J60_RS27370	COG1024	Enoyl-CoA hydratase
D1J60_RS27395	COG1960	acyl-CoA dehydrogenase activity
D1J60_RS27430	COG3938	Belongs to the proline racemase family
D1J60_RS27455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1J60_RS27460	COG0601	transmembrane transport
D1J60_RS27465	COG0444	Belongs to the ABC transporter superfamily
D1J60_RS27470	COG4608	Belongs to the ABC transporter superfamily
D1J60_RS27525	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D1J60_RS27530	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D1J60_RS27535	COG1653	transport
D1J60_RS27540	COG1175	transmembrane transport
D1J60_RS27545	COG0395	ABC-type sugar transport system, permease component
D1J60_RS27560	COG1940	carbohydrate kinase activity
D1J60_RS27565	COG4213	ABC transporter substrate-binding protein
D1J60_RS27575	COG4214	carbohydrate transport
D1J60_RS27580	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D1J60_RS27585	COG0531	amino acid
D1J60_RS27590	COG1316	TRANSCRIPTIONal
D1J60_RS27605	COG2089	acid synthase
D1J60_RS27610	COG1083	cytidylyl-transferase
D1J60_RS27620	COG1215	transferase activity, transferring glycosyl groups
D1J60_RS27630	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1J60_RS27630	COG1024	Enoyl-CoA hydratase
D1J60_RS27635	COG0183	Belongs to the thiolase family
D1J60_RS27640	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D1J60_RS27655	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D1J60_RS27660	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1J60_RS27670	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D1J60_RS27675	COG3253	May function as heme-dependent peroxidase
D1J60_RS27680	COG0596	Alpha beta hydrolase
D1J60_RS27695	COG3220	belongs to the UPF0276 family
D1J60_RS27710	COG1116	anion transmembrane transporter activity
D1J60_RS27750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D1J60_RS27755	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1J60_RS27775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1J60_RS27780	COG0463	Glycosyl transferase, family 2
D1J60_RS27785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1J60_RS27810	COG3511	phospholipase C
D1J60_RS27820	COG1396	sequence-specific DNA binding
D1J60_RS27835	COG0504	CTP synthase activity
D1J60_RS27945	COG0667	Aldo Keto reductase
D1J60_RS27950	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D1J60_RS27960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1J60_RS27965	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D1J60_RS27985	COG0529	Catalyzes the synthesis of activated sulfate
D1J60_RS27990	COG0175	sulfate reduction
D1J60_RS28015	COG1960	acyl-CoA dehydrogenase activity
D1J60_RS28040	COG4585	Histidine kinase
D1J60_RS28045	COG2197	response regulator
D1J60_RS28050	COG1162	GTPase activity
D1J60_RS28065	COG0028	Belongs to the TPP enzyme family
D1J60_RS28085	COG1802	Transcriptional regulator
D1J60_RS28100	COG3835	regulator
D1J60_RS28120	COG2252	PERMEase
D1J60_RS28135	COG4552	Acetyltransferase involved in intracellular survival and related
D1J60_RS28250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1J60_RS28265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1J60_RS28275	COG4106	trans-aconitate 2-methyltransferase activity
D1J60_RS28295	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D1J60_RS28300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1J60_RS28305	COG1410	methionine synthase
D1J60_RS28305	COG0646	methionine synthase
D1J60_RS28325	COG0367	asparagine synthase
D1J60_RS28330	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1J60_RS28330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1J60_RS28335	COG0438	transferase activity, transferring glycosyl groups
D1J60_RS28370	COG1937	Protein conserved in bacteria
D1J60_RS28380	COG2608	mercury ion transmembrane transporter activity
D1J60_RS28390	COG1937	Protein conserved in bacteria
D1J60_RS28400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1J60_RS28415	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D1J60_RS28435	COG1595	DNA-templated transcription, initiation
D1J60_RS28465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1J60_RS28470	COG0386	Belongs to the glutathione peroxidase family
D1J60_RS28480	COG3960	tartronate-semialdehyde synthase activity
D1J60_RS28490	COG0753	catalase activity
D1J60_RS28495	COG2084	Dehydrogenase
D1J60_RS28500	COG3622	Belongs to the hyi family
D1J60_RS28520	COG2351	hydroxyisourate hydrolase activity
D1J60_RS28535	COG2233	PERMEase
D1J60_RS28575	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D1J60_RS28600	COG2197	response regulator
D1J60_RS28605	COG4585	Histidine kinase
D1J60_RS28615	COG1136	(ABC) transporter
D1J60_RS28615	COG0577	efflux transmembrane transporter activity
D1J60_RS28620	COG1414	Transcriptional regulator
D1J60_RS28625	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1J60_RS28630	COG4266	Belongs to the allantoicase family
D1J60_RS28635	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS28650	COG0673	inositol 2-dehydrogenase activity
D1J60_RS28665	COG1129	ABC transporter
D1J60_RS28670	COG1940	carbohydrate kinase activity
D1J60_RS28695	COG1126	abc transporter atp-binding protein
D1J60_RS28700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1J60_RS28705	COG0765	amino acid transport
D1J60_RS28710	COG0765	amino acid transport
D1J60_RS28720	COG1376	ErfK ybiS ycfS ynhG family protein
D1J60_RS28730	COG0745	RESPONSE REGULATOR receiver
D1J60_RS28735	COG2205	protein histidine kinase activity
D1J60_RS28755	COG0405	Gamma-glutamyltransferase
D1J60_RS28770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1J60_RS28775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1J60_RS28810	COG0464	growth
D1J60_RS28855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1J60_RS28860	COG0483	inositol monophosphate 1-phosphatase activity
D1J60_RS28870	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D1J60_RS28990	COG1335	isochorismatase
D1J60_RS28995	COG1929	Belongs to the glycerate kinase type-1 family
D1J60_RS29000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D1J60_RS29015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D1J60_RS29035	COG0688	phosphatidylethanolamine metabolic process
D1J60_RS29040	COG1960	acyl-CoA dehydrogenase activity
D1J60_RS29055	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1J60_RS29055	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1J60_RS29060	COG0604	alcohol dehydrogenase
D1J60_RS29070	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1J60_RS29105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1J60_RS29125	COG0010	Belongs to the arginase family
D1J60_RS29185	COG0531	amino acid
D1J60_RS29195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1J60_RS29205	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D1J60_RS29210	COG1902	pentaerythritol trinitrate reductase activity
D1J60_RS29210	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1J60_RS29240	COG2154	pterin-4-alpha-carbinolamine dehydratase
D1J60_RS29250	COG0656	L-ascorbic acid biosynthetic process
D1J60_RS29290	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D1J60_RS29295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1J60_RS29305	COG0515	serine threonine protein kinase
D1J60_RS29305	COG2815	serine threonine protein kinase
D1J60_RS29325	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1J60_RS29335	COG2197	response regulator
D1J60_RS29375	COG1486	melibiose metabolic process
D1J60_RS29385	COG0494	nUDIX hydrolase
D1J60_RS29390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1J60_RS29395	COG1793	dna ligase
D1J60_RS29425	COG0488	(ABC) transporter
D1J60_RS29445	COG1515	deoxyribonuclease V activity
D1J60_RS29455	COG3268	Saccharopine dehydrogenase
D1J60_RS29460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1J60_RS29465	COG1960	acyl-CoA dehydrogenase activity
D1J60_RS29470	COG0183	Belongs to the thiolase family
D1J60_RS29475	COG1024	Enoyl-CoA hydratase
D1J60_RS29475	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1J60_RS29485	COG0789	Transcriptional regulator
D1J60_RS29525	COG0300	oxidoreductase activity
D1J60_RS29535	COG0488	(ABC) transporter
D1J60_RS29545	COG4977	sequence-specific DNA binding
D1J60_RS29555	COG1024	Enoyl-CoA hydratase
D1J60_RS29570	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D1J60_RS29590	COG0371	Dehydrogenase
D1J60_RS29610	COG1134	teichoic acid transport
D1J60_RS29610	COG1388	LysM domain
D1J60_RS29615	COG1562	ergosterol biosynthetic process
D1J60_RS29625	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D1J60_RS29635	COG1657	PFAM Prenyltransferase squalene oxidase
D1J60_RS29655	COG2365	Tyrosine phosphatase family
D1J60_RS29665	COG2755	lipolytic protein G-D-S-L family
D1J60_RS29720	COG3958	Transketolase
D1J60_RS29725	COG3959	Transketolase, thiamine diphosphate binding domain
D1J60_RS29740	COG2326	polyphosphate kinase activity
D1J60_RS29745	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D1J60_RS29780	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1J60_RS29780	COG2080	2 iron, 2 sulfur cluster binding
D1J60_RS29795	COG3835	regulator
D1J60_RS29810	COG1595	DNA-templated transcription, initiation
D1J60_RS29820	COG1132	(ABC) transporter
D1J60_RS29850	COG1051	belongs to the nudix hydrolase family
D1J60_RS29865	COG0583	DNA-binding transcription factor activity
D1J60_RS29875	COG0598	Magnesium transport protein CorA
D1J60_RS29885	COG3152	Membrane
D1J60_RS29890	COG2838	Isocitrate dehydrogenase
D1J60_RS29910	COG0247	lactate metabolic process
D1J60_RS29915	COG1139	Iron-sulfur cluster binding protein
D1J60_RS29920	COG1556	Lactate utilization protein
D1J60_RS29925	COG0346	lactoylglutathione lyase activity
D1J60_RS29965	COG0318	PFAM AMP-dependent synthetase and ligase
D1J60_RS29980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1J60_RS29985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1J60_RS30010	COG2175	clavaminate synthase activity
D1J60_RS30020	COG2072	flavoprotein involved in K transport
D1J60_RS30025	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D1J60_RS30050	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D1J60_RS30090	COG0435	Glutathione S-transferase
D1J60_RS30135	COG1335	isochorismatase
D1J60_RS30140	COG1113	amino acid transport
D1J60_RS30155	COG1335	isochorismatase
D1J60_RS30165	COG1024	Enoyl-CoA hydratase
D1J60_RS30195	COG3345	alpha-galactosidase
D1J60_RS30235	COG0277	FAD linked oxidase domain protein
D1J60_RS30265	COG0395	ABC-type sugar transport system, permease component
D1J60_RS30280	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1J60_RS30280	COG1902	pentaerythritol trinitrate reductase activity
D1J60_RS30375	COG4172	Belongs to the ABC transporter superfamily
D1J60_RS30380	COG0444	Belongs to the ABC transporter superfamily
D1J60_RS30385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1J60_RS30395	COG0747	negative chemotaxis
D1J60_RS30400	COG1609	Transcriptional regulator
D1J60_RS30430	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS30440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1J60_RS30460	COG2159	amidohydrolase
D1J60_RS30485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D1J60_RS30490	COG0640	Transcriptional regulator
D1J60_RS30510	COG0640	Transcriptional regulator
D1J60_RS30520	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D1J60_RS30580	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D1J60_RS30610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D1J60_RS30610	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D1J60_RS30680	COG1053	succinate dehydrogenase
D1J60_RS30685	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D1J60_RS30700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1J60_RS30710	COG3360	Dodecin
D1J60_RS30715	COG2182	Extracellular solute-binding protein
D1J60_RS30730	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D1J60_RS30735	COG0121	glutamine amidotransferase
D1J60_RS30740	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D1J60_RS30745	COG3572	ergothioneine biosynthetic process
D1J60_RS30775	COG1609	Transcriptional regulator
D1J60_RS30780	COG0183	Belongs to the thiolase family
D1J60_RS30790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1J60_RS30795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1J60_RS30805	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D1J60_RS30835	COG2813	Specifically methylates the guanine in position
D1J60_RS30895	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D1J60_RS30900	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D1J60_RS30905	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D1J60_RS30920	COG0531	amino acid
D1J60_RS30925	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D1J60_RS30985	COG0142	geranyltranstransferase activity
D1J60_RS30995	COG1051	belongs to the nudix hydrolase family
D1J60_RS31020	COG3835	regulator
D1J60_RS31025	COG0443	Heat shock 70 kDa protein
D1J60_RS31030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D1J60_RS31045	COG0542	response to heat
D1J60_RS31095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D1J60_RS31105	COG5002	protein histidine kinase activity
D1J60_RS31110	COG0745	RESPONSE REGULATOR receiver
D1J60_RS31145	COG2124	cytochrome p450
D1J60_RS31150	COG2957	Belongs to the agmatine deiminase family
D1J60_RS31165	COG2957	Belongs to the agmatine deiminase family
D1J60_RS31175	COG0832	Belongs to the urease beta subunit family
D1J60_RS31175	COG0831	urea catabolic process
D1J60_RS31180	COG0804	urea catabolic process
D1J60_RS31185	COG2957	Belongs to the agmatine deiminase family
D1J60_RS31190	COG0747	negative chemotaxis
D1J60_RS31200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1J60_RS31205	COG0444	Belongs to the ABC transporter superfamily
D1J60_RS31210	COG4608	Belongs to the ABC transporter superfamily
D1J60_RS31240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1J60_RS31250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1J60_RS31275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D1J60_RS31295	COG2205	protein histidine kinase activity
D1J60_RS31300	COG0745	RESPONSE REGULATOR receiver
D1J60_RS31320	COG3835	regulator
D1J60_RS31325	COG0318	PFAM AMP-dependent synthetase and ligase
D1J60_RS31360	COG0393	Putative heavy-metal-binding
D1J60_RS31370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1J60_RS31400	COG2814	Major facilitator Superfamily
D1J60_RS31410	COG3064	Membrane
D1J60_RS31410	COG3583	domain protein
D1J60_RS31410	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D1J60_RS31415	COG2356	endonuclease I
D1J60_RS31420	COG0693	protein deglycase activity
D1J60_RS31425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1J60_RS31450	COG3864	Putative metallopeptidase domain
D1J60_RS31485	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D1J60_RS31495	COG0515	serine threonine protein kinase
D1J60_RS31495	COG2815	serine threonine protein kinase
D1J60_RS31505	COG4585	Histidine kinase
D1J60_RS31510	COG2197	response regulator
D1J60_RS31520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1J60_RS31545	COG1024	Enoyl-CoA hydratase
D1J60_RS31555	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS31570	COG1960	acyl-CoA dehydrogenase activity
D1J60_RS31575	COG1960	acyl-CoA dehydrogenase activity
D1J60_RS31585	COG2304	oxidoreductase activity
D1J60_RS31600	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D1J60_RS31605	COG3511	phospholipase C
D1J60_RS31625	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D1J60_RS31645	COG1301	dicarboxylic acid transport
D1J60_RS31650	COG3290	protein histidine kinase activity
D1J60_RS31655	COG4565	transcriptional regulatory protein
D1J60_RS31670	COG0076	glutamate decarboxylase activity
D1J60_RS31690	COG0800	Aldolase
D1J60_RS31755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D1J60_RS31760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1J60_RS31765	COG1120	ATPase activity
D1J60_RS31775	COG0667	Aldo Keto reductase
D1J60_RS31785	COG1131	(ABC) transporter
D1J60_RS31790	COG1793	dna ligase
D1J60_RS31805	COG0477	Major facilitator Superfamily
D1J60_RS31810	COG4412	M6 family metalloprotease domain protein
D1J60_RS31810	COG4412	M6 family metalloprotease domain protein
D1J60_RS31810	COG1404	Belongs to the peptidase S8 family
D1J60_RS31810	COG1404	Belongs to the peptidase S8 family
D1J60_RS31835	COG3265	gluconokinase activity
D1J60_RS31845	COG1132	(ABC) transporter
D1J60_RS31865	COG0436	Aminotransferase
D1J60_RS31895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D1J60_RS31900	COG2205	protein histidine kinase activity
D1J60_RS31905	COG0745	RESPONSE REGULATOR receiver
D1J60_RS31920	COG2197	response regulator
D1J60_RS31925	COG4585	Histidine kinase
D1J60_RS31950	COG3629	intracellular signal transduction
D1J60_RS31950	COG3903	Transcriptional regulator
D1J60_RS31970	COG2226	methyltransferase
D1J60_RS31975	COG4264	IucA IucC family
D1J60_RS31985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1J60_RS32000	COG1191	sigma factor activity
D1J60_RS32005	COG0517	IMP dehydrogenase activity
D1J60_RS32005	COG4175	Glycine betaine
D1J60_RS32015	COG2409	Drug exporters of the RND superfamily
D1J60_RS32020	COG4585	Histidine kinase
D1J60_RS32025	COG2197	response regulator
D1J60_RS32035	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D1J60_RS32080	COG2272	Belongs to the type-B carboxylesterase lipase family
D1J60_RS32090	COG1796	DNA polymerase
D1J60_RS32090	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D1J60_RS32115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1J60_RS32130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1J60_RS32135	COG1278	Cold shock
D1J60_RS32140	COG2304	oxidoreductase activity
D1J60_RS32185	COG0477	Major facilitator Superfamily
D1J60_RS32255	COG3629	intracellular signal transduction
D1J60_RS32255	COG3903	Transcriptional regulator
D1J60_RS32260	COG0009	L-threonylcarbamoyladenylate synthase
D1J60_RS32265	COG1376	ErfK ybiS ycfS ynhG family protein
D1J60_RS32270	COG0477	Major facilitator Superfamily
D1J60_RS32275	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D1J60_RS32285	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D1J60_RS32290	COG2197	response regulator
D1J60_RS32310	COG2132	Multicopper oxidase
D1J60_RS32350	COG1309	transcriptional regulator
D1J60_RS32355	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS32365	COG4044	May play a role in the intracellular transport of hydrophobic ligands
D1J60_RS32405	COG1846	Transcriptional regulator
D1J60_RS32415	COG0668	transmembrane transport
D1J60_RS32435	COG0431	NADPH-dependent FMN reductase
D1J60_RS32450	COG1957	nucleoside hydrolase
D1J60_RS32470	COG2223	nitrite transmembrane transporter activity
D1J60_RS32475	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D1J60_RS32480	COG0438	transferase activity, transferring glycosyl groups
D1J60_RS32485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1J60_RS32490	COG0765	amino acid transport
D1J60_RS32535	COG1045	serine acetyltransferase
D1J60_RS32560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D1J60_RS32575	COG2409	Drug exporters of the RND superfamily
D1J60_RS32600	COG0657	acetylesterase activity
D1J60_RS32610	COG1609	Transcriptional regulator
D1J60_RS32635	COG1021	2,3-dihydroxybenzoate-AMP ligase
D1J60_RS32640	COG1136	(ABC) transporter
D1J60_RS32640	COG0577	efflux transmembrane transporter activity
D1J60_RS32645	COG1136	(ABC) transporter
D1J60_RS32645	COG0577	efflux transmembrane transporter activity
D1J60_RS32650	COG2197	response regulator
D1J60_RS32655	COG4585	Histidine kinase
D1J60_RS32660	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D1J60_RS32675	COG3290	protein histidine kinase activity
D1J60_RS32695	COG3973	AAA domain
D1J60_RS32700	COG4585	Histidine kinase
D1J60_RS32755	COG0596	Alpha beta hydrolase
D1J60_RS32770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1J60_RS32775	COG1725	Transcriptional regulator
D1J60_RS32780	COG4133	protoheme IX ABC transporter activity
D1J60_RS32790	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS32800	COG3321	synthase
D1J60_RS32800	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS32800	COG0604	alcohol dehydrogenase
D1J60_RS32820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1J60_RS32850	COG3527	Alpha-acetolactate decarboxylase
D1J60_RS32865	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D1J60_RS32875	COG0791	NLP P60 protein
D1J60_RS32885	COG0432	Pfam Uncharacterised protein family UPF0047
D1J60_RS32895	COG0187	DNA topoisomerase II activity
D1J60_RS32905	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1J60_RS32920	COG0666	response to abiotic stimulus
D1J60_RS32940	COG1846	Transcriptional regulator
D1J60_RS32950	COG0583	DNA-binding transcription factor activity
D1J60_RS32955	COG2197	response regulator
D1J60_RS32960	COG1132	(ABC) transporter
D1J60_RS32965	COG1132	(ABC) transporter
D1J60_RS32975	COG0515	serine threonine protein kinase
D1J60_RS32985	COG1309	transcriptional regulator
D1J60_RS32990	COG0277	FAD linked oxidase domain protein
D1J60_RS32990	COG0277	FAD linked oxidase domain protein
D1J60_RS33035	COG0515	serine threonine protein kinase
D1J60_RS33035	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1J60_RS33075	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1J60_RS33095	COG2045	Belongs to the ComB family
D1J60_RS33110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1J60_RS33160	COG0110	maltose O-acetyltransferase activity
D1J60_RS33240	COG0697	spore germination
D1J60_RS33245	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1J60_RS33255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1J60_RS33265	COG0142	geranyltranstransferase activity
D1J60_RS33295	COG2326	polyphosphate kinase activity
D1J60_RS33335	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS33355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D1J60_RS33370	COG0784	Response regulator, receiver
D1J60_RS33375	COG4251	negative regulation of phosphorylation
D1J60_RS33395	COG1846	Transcriptional regulator
D1J60_RS33410	COG2208	phosphoserine phosphatase activity
D1J60_RS33410	COG2770	Histidine kinase
D1J60_RS33435	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D1J60_RS33450	COG0477	Major facilitator Superfamily
D1J60_RS33460	COG0456	acetyltransferase
D1J60_RS33465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1J60_RS33470	COG0765	amino acid transport
D1J60_RS33475	COG0765	amino acid transport
D1J60_RS33480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1J60_RS33485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1J60_RS33490	COG1126	abc transporter atp-binding protein
D1J60_RS33540	COG1595	DNA-templated transcription, initiation
D1J60_RS33550	COG0723	plastoquinol--plastocyanin reductase activity
D1J60_RS33550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1J60_RS33570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1J60_RS33575	COG0601	transmembrane transport
D1J60_RS33600	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D1J60_RS33600	COG0237	dephospho-CoA kinase activity
D1J60_RS33635	COG0701	Predicted permease
D1J60_RS33660	COG1733	regulation of RNA biosynthetic process
D1J60_RS33805	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1J60_RS33830	COG1714	RDD family
D1J60_RS33875	COG1595	DNA-templated transcription, initiation
D1J60_RS33950	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D1J60_RS34025	COG3629	intracellular signal transduction
D1J60_RS34025	COG3903	Transcriptional regulator
D1J60_RS34030	COG2197	response regulator
D1J60_RS34035	COG4585	Histidine kinase
D1J60_RS34040	COG1136	(ABC) transporter
D1J60_RS34040	COG0577	efflux transmembrane transporter activity
D1J60_RS34070	COG1335	isochorismatase
D1J60_RS34080	COG4172	Belongs to the ABC transporter superfamily
D1J60_RS34085	COG4171	peptide transport system, permease
D1J60_RS34090	COG0601	transmembrane transport
D1J60_RS34095	COG4166	transmembrane transport
D1J60_RS34110	COG0019	diaminopimelate decarboxylase activity
D1J60_RS34115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D1J60_RS34120	COG0534	Mate efflux family protein
D1J60_RS34135	COG0300	oxidoreductase activity
D1J60_RS34190	COG4977	sequence-specific DNA binding
D1J60_RS34205	COG4221	oxidoreductase activity
D1J60_RS34215	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D1J60_RS34255	COG2318	DinB family
D1J60_RS34270	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D1J60_RS34290	COG3119	arylsulfatase activity
D1J60_RS34295	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D1J60_RS34300	COG3119	arylsulfatase activity
D1J60_RS34310	COG3903	Transcriptional regulator
D1J60_RS34310	COG3629	intracellular signal transduction
D1J60_RS34355	COG4585	Histidine kinase
D1J60_RS34360	COG2197	response regulator
D1J60_RS34375	COG1733	regulation of RNA biosynthetic process
D1J60_RS34390	COG2124	cytochrome p450
D1J60_RS34415	COG2079	MmgE PrpD family protein
D1J60_RS34425	COG2301	Belongs to the HpcH HpaI aldolase family
D1J60_RS34430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1J60_RS34445	COG1335	isochorismatase
D1J60_RS34450	COG0604	alcohol dehydrogenase
D1J60_RS34460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1J60_RS34465	COG2301	Belongs to the HpcH HpaI aldolase family
D1J60_RS34475	COG1309	transcriptional regulator
D1J60_RS34525	COG0596	Alpha beta hydrolase
D1J60_RS34525	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1J60_RS34535	COG0667	Aldo Keto reductase
D1J60_RS34540	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS34545	COG1309	transcriptional regulator
D1J60_RS34565	COG2226	methyltransferase
D1J60_RS34585	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D1J60_RS34610	COG0574	Belongs to the PEP-utilizing enzyme family
D1J60_RS34610	COG3848	Pyruvate phosphate dikinase
D1J60_RS34615	COG4552	Acetyltransferase involved in intracellular survival and related
D1J60_RS34630	COG0671	phosphoesterase, PA-phosphatase related
D1J60_RS34665	COG3119	arylsulfatase activity
D1J60_RS34675	COG2267	carboxylic ester hydrolase activity
D1J60_RS34680	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS34700	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D1J60_RS34785	COG2197	response regulator
D1J60_RS34790	COG4585	Histidine kinase
D1J60_RS34800	COG0714	Associated with various cellular activities
D1J60_RS34805	COG3864	Putative metallopeptidase domain
D1J60_RS34810	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1J60_RS34865	COG2207	Transcriptional regulator
D1J60_RS34865	COG3708	Transcriptional regulator
D1J60_RS34880	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1J60_RS34885	COG0823	Involved in the tonB-independent uptake of proteins
D1J60_RS34895	COG2378	regulation of single-species biofilm formation
D1J60_RS34945	COG0583	DNA-binding transcription factor activity
D1J60_RS35010	COG1192	Involved in chromosome partitioning
D1J60_RS35050	COG2318	DinB family
D1J60_RS35100	COG4221	oxidoreductase activity
D1J60_RS35105	COG0789	Transcriptional regulator
D1J60_RS35155	COG1132	(ABC) transporter
D1J60_RS35230	COG0006	proline dipeptidase activity
D1J60_RS35240	COG0488	(ABC) transporter
D1J60_RS35250	COG2205	protein histidine kinase activity
D1J60_RS35260	COG1953	Uracil, thiamine, allantoin
D1J60_RS35340	COG5504	Zn-dependent protease
D1J60_RS35345	COG2815	serine threonine protein kinase
D1J60_RS35345	COG0515	serine threonine protein kinase
D1J60_RS35365	COG0789	Transcriptional regulator
D1J60_RS35450	COG4175	Glycine betaine
D1J60_RS35450	COG0517	IMP dehydrogenase activity
D1J60_RS35470	COG1335	isochorismatase
D1J60_RS35475	COG2259	Doxx family
D1J60_RS35480	COG2267	carboxylic ester hydrolase activity
D1J60_RS35485	COG1228	amidohydrolase
D1J60_RS35505	COG0222	ribosome binding
D1J60_RS35590	COG1295	ribonuclease BN
D1J60_RS35610	COG4221	oxidoreductase activity
D1J60_RS35620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1J60_RS35625	COG0626	cystathionine gamma-synthase activity
D1J60_RS35635	COG0456	acetyltransferase
D1J60_RS35640	COG1819	glycosyl
D1J60_RS35650	COG1132	(ABC) transporter
D1J60_RS35740	COG1028	Short-chain dehydrogenase reductase Sdr
D1J60_RS35755	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1J60_RS35825	COG1278	Cold shock
D1J60_RS35830	COG0513	Belongs to the DEAD box helicase family
D1J60_RS35855	COG0583	DNA-binding transcription factor activity
D1J60_RS35945	COG1733	regulation of RNA biosynthetic process
D1J60_RS35955	COG2910	NAD(P)H-binding
D1J60_RS36010	COG2801	Transposase and inactivated derivatives
D1J60_RS36010	COG3415	Transposase
D1J60_RS36015	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D1J60_RS36115	COG5492	domain, Protein
D1J60_RS36115	COG4932	domain protein
D1J60_RS36140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1J60_RS36250	COG1316	TRANSCRIPTIONal
D1J60_RS36270	COG0477	Major facilitator Superfamily
D1J60_RS36285	COG0477	Major facilitator Superfamily
D1J60_RS36290	COG0604	alcohol dehydrogenase
D1J60_RS36290	COG3321	synthase
D1J60_RS36305	COG3321	synthase
D1J60_RS36305	COG0604	alcohol dehydrogenase
D1J60_RS36315	COG1472	Belongs to the glycosyl hydrolase 3 family
D1J60_RS36320	COG0512	Glutamine amidotransferase of anthranilate synthase
D1J60_RS36320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1J60_RS36330	COG1819	glycosyl
D1J60_RS36340	COG2124	cytochrome p450
D1J60_RS36350	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D1J60_RS36360	COG0531	amino acid
D1J60_RS36385	COG3559	Exporter of polyketide antibiotics
D1J60_RS36390	COG1131	(ABC) transporter
D1J60_RS36430	COG0604	alcohol dehydrogenase
D1J60_RS36430	COG3321	synthase
D1J60_RS36445	COG0604	alcohol dehydrogenase
D1J60_RS36445	COG3321	synthase
D1J60_RS36450	COG3321	synthase
D1J60_RS36450	COG0604	alcohol dehydrogenase
D1J60_RS36460	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1J60_RS36470	COG1131	(ABC) transporter
D1J60_RS36475	COG0318	PFAM AMP-dependent synthetase and ligase
D1J60_RS36480	COG3903	Transcriptional regulator
D1J60_RS36480	COG3629	intracellular signal transduction
D1J60_RS36490	COG0318	PFAM AMP-dependent synthetase and ligase
D1J60_RS36495	COG1960	acyl-CoA dehydrogenase activity
D1J60_RS36510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1J60_RS36535	COG2197	response regulator
D1J60_RS36545	COG2211	Major facilitator Superfamily
D1J60_RS36550	COG0309	Hydrogenase expression formation protein (HypE)
D1J60_RS36560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1J60_RS36575	COG0435	Glutathione S-transferase
D1J60_RS36595	COG2154	pterin-4-alpha-carbinolamine dehydratase
D1J60_RS36625	COG0789	Transcriptional regulator
D1J60_RS36630	COG0596	Alpha beta hydrolase
D1J60_RS36645	COG0318	PFAM AMP-dependent synthetase and ligase
D1J60_RS36655	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D1J60_RS36665	COG2197	response regulator
D1J60_RS36670	COG4585	Histidine kinase
D1J60_RS36690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1J60_RS36695	COG3321	synthase
D1J60_RS36695	COG3321	synthase
D1J60_RS36695	COG0604	alcohol dehydrogenase
D1J60_RS36695	COG0604	alcohol dehydrogenase
D1J60_RS36700	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D1J60_RS36735	COG1960	acyl-CoA dehydrogenase activity
D1J60_RS36750	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1J60_RS36755	COG3629	intracellular signal transduction
D1J60_RS36770	COG0697	spore germination
D1J60_RS36815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1J60_RS36820	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D1J60_RS36865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1J60_RS36895	COG0745	RESPONSE REGULATOR receiver
D1J60_RS36900	COG1309	transcriptional regulator
D1J60_RS36905	COG2867	negative regulation of translational initiation
D1J60_RS36930	COG0702	epimerase
D1J60_RS36940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1J60_RS36955	COG0702	epimerase
D1J60_RS36975	COG2318	DinB family
D1J60_RS37005	COG0475	glutathione-regulated potassium exporter activity
D1J60_RS37025	COG1192	Involved in chromosome partitioning
D1J60_RS37030	COG1475	DNA binding
D1J60_RS37055	COG1063	alcohol dehydrogenase
D1J60_RS37060	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis