locus-tag	class	description
C5L38_RS00025	COG0419	ATPase involved in DNA repair
C5L38_RS00030	COG0420	3'-5' exonuclease activity
C5L38_RS00055	COG4942	peptidase
C5L38_RS00275	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C5L38_RS00315	COG3209	COG3209 Rhs family protein
C5L38_RS00315	COG4104	PAAR repeat-containing protein
C5L38_RS00325	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C5L38_RS00410	COG1595	DNA-templated transcription, initiation
C5L38_RS00475	COG0367	asparagine synthase
C5L38_RS00585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5L38_RS00620	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C5L38_RS00755	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C5L38_RS00835	COG2197	response regulator
C5L38_RS00925	COG0640	Transcriptional regulator
C5L38_RS00930	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C5L38_RS00935	COG1215	transferase activity, transferring glycosyl groups
C5L38_RS01030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5L38_RS01080	COG0366	Alpha amylase catalytic
C5L38_RS01085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5L38_RS01155	COG0539	negative regulation of cytoplasmic translation
C5L38_RS01180	COG0673	inositol 2-dehydrogenase activity
C5L38_RS01205	COG1404	Belongs to the peptidase S8 family
C5L38_RS01230	COG1472	Belongs to the glycosyl hydrolase 3 family
C5L38_RS01260	COG2815	serine threonine protein kinase
C5L38_RS01260	COG0515	serine threonine protein kinase
C5L38_RS01270	COG2124	cytochrome p450
C5L38_RS01280	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C5L38_RS01290	COG4106	trans-aconitate 2-methyltransferase activity
C5L38_RS01340	COG1295	ribonuclease BN
C5L38_RS01345	COG1028	Short-chain dehydrogenase reductase Sdr
C5L38_RS01365	COG3795	YCII-related domain
C5L38_RS01370	COG4941	Belongs to the sigma-70 factor family
C5L38_RS01395	COG1028	Short-chain dehydrogenase reductase Sdr
C5L38_RS01410	COG0723	plastoquinol--plastocyanin reductase activity
C5L38_RS01410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5L38_RS01440	COG2124	cytochrome p450
C5L38_RS01450	COG1793	dna ligase
C5L38_RS01450	COG3285	dna ligase
C5L38_RS01460	COG0589	response to stress
C5L38_RS01465	COG1335	isochorismatase
C5L38_RS01505	COG0714	Associated with various cellular activities
C5L38_RS01535	COG1028	Short-chain dehydrogenase reductase Sdr
C5L38_RS01570	COG0693	protein deglycase activity
C5L38_RS01575	COG1191	sigma factor activity
C5L38_RS01630	COG4977	sequence-specific DNA binding
C5L38_RS01645	COG0596	Alpha beta hydrolase
C5L38_RS01665	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C5L38_RS01670	COG1349	DNA-binding transcription factor activity
C5L38_RS01695	COG0254	rRNA binding
C5L38_RS01700	COG0702	epimerase
C5L38_RS01720	COG1051	belongs to the nudix hydrolase family
C5L38_RS01745	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C5L38_RS01755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5L38_RS01760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5L38_RS01770	COG0477	Major facilitator Superfamily
C5L38_RS01785	COG1309	transcriptional regulator
C5L38_RS01790	COG1960	acyl-CoA dehydrogenase activity
C5L38_RS01800	COG1473	amidohydrolase
C5L38_RS01835	COG1959	2 iron, 2 sulfur cluster binding
C5L38_RS01840	COG1017	nitric oxide dioxygenase activity
C5L38_RS01840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5L38_RS01860	COG0726	polysaccharide deacetylase
C5L38_RS01875	COG2018	Roadblock/LC7 domain
C5L38_RS01925	COG1418	mRNA catabolic process
C5L38_RS01935	COG3239	Fatty acid desaturase
C5L38_RS01940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5L38_RS01955	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C5L38_RS01960	COG2124	cytochrome p450
C5L38_RS01970	COG2267	carboxylic ester hydrolase activity
C5L38_RS01975	COG0435	Glutathione S-transferase
C5L38_RS01985	COG2208	phosphoserine phosphatase activity
C5L38_RS01985	COG2770	Histidine kinase
C5L38_RS02005	COG0473	3-isopropylmalate dehydrogenase activity
C5L38_RS02015	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C5L38_RS02090	COG0385	Bile acid
C5L38_RS02100	COG2409	Drug exporters of the RND superfamily
C5L38_RS02110	COG0583	DNA-binding transcription factor activity
C5L38_RS02115	COG1012	belongs to the aldehyde dehydrogenase family
C5L38_RS02120	COG0531	amino acid
C5L38_RS02140	COG0318	PFAM AMP-dependent synthetase and ligase
C5L38_RS02145	COG1028	Short-chain dehydrogenase reductase Sdr
C5L38_RS02150	COG1960	acyl-CoA dehydrogenase activity
C5L38_RS02160	COG0477	Major facilitator Superfamily
C5L38_RS02175	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C5L38_RS02180	COG3268	Saccharopine dehydrogenase
C5L38_RS02185	COG1012	belongs to the aldehyde dehydrogenase family
C5L38_RS02205	COG1902	pentaerythritol trinitrate reductase activity
C5L38_RS02205	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5L38_RS02220	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5L38_RS02220	COG1902	pentaerythritol trinitrate reductase activity
C5L38_RS02225	COG1309	transcriptional regulator
C5L38_RS02250	COG1309	transcriptional regulator
C5L38_RS02290	COG1595	DNA-templated transcription, initiation
C5L38_RS02305	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C5L38_RS02310	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C5L38_RS02340	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
C5L38_RS02380	COG0180	Tryptophanyl-tRNA synthetase
C5L38_RS02390	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C5L38_RS02400	COG1802	Transcriptional regulator
C5L38_RS02405	COG0402	S-adenosylhomocysteine deaminase activity
C5L38_RS02450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5L38_RS02455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5L38_RS02460	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5L38_RS02510	COG0395	ABC-type sugar transport system, permease component
C5L38_RS02550	COG1982	Orn Lys Arg decarboxylase major
C5L38_RS02555	COG0367	asparagine synthase
C5L38_RS02565	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C5L38_RS02595	COG2188	Transcriptional regulator
C5L38_RS02605	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C5L38_RS02610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5L38_RS02615	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C5L38_RS02620	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C5L38_RS02640	COG0366	Alpha amylase catalytic
C5L38_RS02640	COG1874	Beta-galactosidase
C5L38_RS02655	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5L38_RS02655	COG0493	'glutamate synthase
C5L38_RS02680	COG1051	belongs to the nudix hydrolase family
C5L38_RS02700	COG0444	Belongs to the ABC transporter superfamily
C5L38_RS02705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5L38_RS02710	COG0601	transmembrane transport
C5L38_RS02720	COG1960	acyl-CoA dehydrogenase activity
C5L38_RS02725	COG1960	acyl-CoA dehydrogenase activity
C5L38_RS02740	COG3634	alkyl hydroperoxide reductase activity
C5L38_RS02750	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C5L38_RS02760	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C5L38_RS02775	COG1595	DNA-templated transcription, initiation
C5L38_RS02785	COG0765	amino acid transport
C5L38_RS02790	COG0765	amino acid transport
C5L38_RS02795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5L38_RS02800	COG1126	abc transporter atp-binding protein
C5L38_RS02810	COG0825	malonyl-CoA metabolic process
C5L38_RS02810	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C5L38_RS02825	COG1191	sigma factor activity
C5L38_RS02900	COG0326	Molecular chaperone. Has ATPase activity
C5L38_RS02925	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C5L38_RS02950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5L38_RS02955	COG0765	amino acid transport
C5L38_RS02960	COG0765	amino acid transport
C5L38_RS02965	COG1126	abc transporter atp-binding protein
C5L38_RS02970	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C5L38_RS02975	COG1115	amino acid carrier protein
C5L38_RS02980	COG1482	cell wall glycoprotein biosynthetic process
C5L38_RS02990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5L38_RS03000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5L38_RS03030	COG2175	clavaminate synthase activity
C5L38_RS03075	COG1129	ABC transporter
C5L38_RS03080	COG1079	Belongs to the binding-protein-dependent transport system permease family
C5L38_RS03095	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C5L38_RS03100	COG1073	alpha beta
C5L38_RS03110	COG1063	alcohol dehydrogenase
C5L38_RS03125	COG1012	belongs to the aldehyde dehydrogenase family
C5L38_RS03150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5L38_RS03165	COG0183	Belongs to the thiolase family
C5L38_RS03170	COG1129	ABC transporter
C5L38_RS03185	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5L38_RS03190	COG1063	alcohol dehydrogenase
C5L38_RS03215	COG1012	belongs to the aldehyde dehydrogenase family
C5L38_RS03220	COG0477	Major facilitator Superfamily
C5L38_RS03225	COG2301	Belongs to the HpcH HpaI aldolase family
C5L38_RS03235	COG1960	acyl-CoA dehydrogenase activity
C5L38_RS03240	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C5L38_RS03245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5L38_RS03260	COG2181	nitrate reductase activity
C5L38_RS03260	COG0247	lactate metabolic process
C5L38_RS03265	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C5L38_RS03290	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
C5L38_RS03295	COG2301	Belongs to the HpcH HpaI aldolase family
C5L38_RS03300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5L38_RS03305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5L38_RS03310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5L38_RS03320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5L38_RS03335	COG3284	Transcriptional regulator
C5L38_RS03400	COG1012	belongs to the aldehyde dehydrogenase family
C5L38_RS03405	COG1073	alpha beta
C5L38_RS03455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5L38_RS03460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5L38_RS03465	COG0183	Belongs to the thiolase family
C5L38_RS03475	COG0596	Alpha beta hydrolase
C5L38_RS03485	COG3572	ergothioneine biosynthetic process
C5L38_RS03490	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C5L38_RS03495	COG0121	glutamine amidotransferase
C5L38_RS03500	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
C5L38_RS03515	COG2182	Extracellular solute-binding protein
C5L38_RS03530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5L38_RS03555	COG0477	Major facilitator Superfamily
C5L38_RS03570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C5L38_RS03575	COG1053	succinate dehydrogenase
C5L38_RS03645	COG3275	phosphorelay sensor kinase activity
C5L38_RS03720	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C5L38_RS03755	COG2072	flavoprotein involved in K transport
C5L38_RS03760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C5L38_RS03775	COG1012	belongs to the aldehyde dehydrogenase family
C5L38_RS03785	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C5L38_RS03790	COG0318	PFAM AMP-dependent synthetase and ligase
C5L38_RS03800	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5L38_RS03820	COG2124	cytochrome p450
C5L38_RS03820	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C5L38_RS03865	COG0477	Major facilitator Superfamily
C5L38_RS03875	COG2124	cytochrome p450
C5L38_RS03930	COG0235	Class ii aldolase
C5L38_RS03935	COG3395	kinase activity
C5L38_RS03940	COG0473	3-isopropylmalate dehydrogenase activity
C5L38_RS03945	COG1082	Xylose isomerase domain protein TIM barrel
C5L38_RS03960	COG2851	Citrate transporter
C5L38_RS04005	COG0017	Asparaginyl-tRNA synthetase
C5L38_RS04025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5L38_RS04030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5L38_RS04050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5L38_RS04065	COG3629	intracellular signal transduction
C5L38_RS04065	COG3903	Transcriptional regulator
C5L38_RS04095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C5L38_RS04110	COG1231	oxidoreductase activity
C5L38_RS04130	COG0596	Alpha beta hydrolase
C5L38_RS04150	COG0456	acetyltransferase
C5L38_RS04195	COG1309	transcriptional regulator
C5L38_RS04215	COG2910	NAD(P)H-binding
C5L38_RS04320	COG1408	metallophosphoesterase
C5L38_RS04350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5L38_RS04390	COG2197	response regulator
C5L38_RS04395	COG4585	Histidine kinase
C5L38_RS04400	COG2409	Drug exporters of the RND superfamily
C5L38_RS04415	COG2160	L-arabinose isomerase activity
C5L38_RS04425	COG1609	Transcriptional regulator
C5L38_RS04435	COG1129	ABC transporter
C5L38_RS04440	COG4214	carbohydrate transport
C5L38_RS04450	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5L38_RS04465	COG1879	ABC-type sugar transport system periplasmic component
C5L38_RS04470	COG0432	Pfam Uncharacterised protein family UPF0047
C5L38_RS04480	COG1595	DNA-templated transcription, initiation
C5L38_RS04485	COG5297	Belongs to the glycosyl hydrolase family 6
C5L38_RS04490	COG5297	Belongs to the glycosyl hydrolase family 6
C5L38_RS04510	COG0395	ABC-type sugar transport system, permease component
C5L38_RS04530	COG0584	glycerophosphoryl diester phosphodiesterase
C5L38_RS04545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C5L38_RS04590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5L38_RS04625	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C5L38_RS04635	COG0254	rRNA binding
C5L38_RS04640	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C5L38_RS04645	COG2264	protein methyltransferase activity
C5L38_RS04650	COG0243	molybdopterin cofactor binding
C5L38_RS04665	COG3336	cytochrome c oxidase
C5L38_RS04685	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C5L38_RS04740	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C5L38_RS04745	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C5L38_RS04750	COG0384	phenazine biosynthesis protein PhzF
C5L38_RS04800	COG1595	DNA-templated transcription, initiation
C5L38_RS04815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5L38_RS04820	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C5L38_RS04840	COG2188	Transcriptional regulator
C5L38_RS04845	COG2255	four-way junction helicase activity
C5L38_RS04885	COG1132	(ABC) transporter
C5L38_RS04965	COG1404	Belongs to the peptidase S8 family
C5L38_RS04980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5L38_RS05005	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C5L38_RS05010	COG0542	response to heat
C5L38_RS05020	COG0514	ATP-dependent DNA helicase (RecQ)
C5L38_RS05025	COG1132	(ABC) transporter
C5L38_RS05045	COG3237	CsbD-like
C5L38_RS05065	COG0438	transferase activity, transferring glycosyl groups
C5L38_RS05075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5L38_RS05080	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C5L38_RS05105	COG2080	2 iron, 2 sulfur cluster binding
C5L38_RS05110	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C5L38_RS05115	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C5L38_RS05125	COG1960	acyl-CoA dehydrogenase activity
C5L38_RS05165	COG1309	transcriptional regulator
C5L38_RS05210	COG2755	lipolytic protein G-D-S-L family
C5L38_RS05220	COG2365	Tyrosine phosphatase family
C5L38_RS05245	COG1657	PFAM Prenyltransferase squalene oxidase
C5L38_RS05255	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C5L38_RS05270	COG1562	ergosterol biosynthetic process
C5L38_RS05275	COG1134	teichoic acid transport
C5L38_RS05275	COG1388	LysM domain
C5L38_RS05320	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C5L38_RS05330	COG1024	Enoyl-CoA hydratase
C5L38_RS05360	COG0488	(ABC) transporter
C5L38_RS05375	COG2936	dipeptidyl-peptidase activity
C5L38_RS05390	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C5L38_RS05415	COG1024	Enoyl-CoA hydratase
C5L38_RS05415	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5L38_RS05420	COG0183	Belongs to the thiolase family
C5L38_RS05425	COG1960	acyl-CoA dehydrogenase activity
C5L38_RS05430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5L38_RS05435	COG3268	Saccharopine dehydrogenase
C5L38_RS05445	COG1515	deoxyribonuclease V activity
C5L38_RS05460	COG0673	inositol 2-dehydrogenase activity
C5L38_RS05490	COG1028	Short-chain dehydrogenase reductase Sdr
C5L38_RS05495	COG0318	PFAM AMP-dependent synthetase and ligase
C5L38_RS05530	COG0702	epimerase
C5L38_RS05565	COG0488	(ABC) transporter
C5L38_RS05625	COG3012	SEC-C Motif Domain Protein
C5L38_RS05630	COG1486	melibiose metabolic process
C5L38_RS05675	COG0673	inositol 2-dehydrogenase activity
C5L38_RS05685	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5L38_RS05690	COG1129	ABC transporter
C5L38_RS05695	COG1940	carbohydrate kinase activity
C5L38_RS05695	COG1846	Transcriptional regulator
C5L38_RS05710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5L38_RS05730	COG0583	DNA-binding transcription factor activity
C5L38_RS05740	COG0656	L-ascorbic acid biosynthetic process
C5L38_RS05755	COG0702	epimerase
C5L38_RS05765	COG2154	pterin-4-alpha-carbinolamine dehydratase
C5L38_RS05780	COG2318	DinB family
C5L38_RS05825	COG2226	methyltransferase
C5L38_RS05845	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C5L38_RS05855	COG2226	methyltransferase
C5L38_RS05855	COG1073	alpha beta
C5L38_RS05860	COG1619	proteins homologs of microcin C7 resistance protein MccF
C5L38_RS05870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5L38_RS05875	COG2362	D-Aminopeptidase
C5L38_RS05900	COG0596	Alpha beta hydrolase
C5L38_RS05910	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5L38_RS05920	COG0604	alcohol dehydrogenase
C5L38_RS05925	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C5L38_RS05925	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C5L38_RS05940	COG1960	acyl-CoA dehydrogenase activity
C5L38_RS05945	COG0688	phosphatidylethanolamine metabolic process
C5L38_RS05955	COG0456	acetyltransferase
C5L38_RS05960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5L38_RS05975	COG0559	Belongs to the binding-protein-dependent transport system permease family
C5L38_RS05995	COG1929	Belongs to the glycerate kinase type-1 family
C5L38_RS06000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C5L38_RS06020	COG0009	L-threonylcarbamoyladenylate synthase
C5L38_RS06030	COG0483	inositol monophosphate 1-phosphatase activity
C5L38_RS06050	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C5L38_RS06100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5L38_RS06105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5L38_RS06115	COG0604	alcohol dehydrogenase
C5L38_RS06115	COG3321	synthase
C5L38_RS06145	COG0386	Belongs to the glutathione peroxidase family
C5L38_RS06150	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C5L38_RS06220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5L38_RS06230	COG0667	Aldo Keto reductase
C5L38_RS06250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C5L38_RS06285	COG0405	Gamma-glutamyltransferase
C5L38_RS06305	COG0765	amino acid transport
C5L38_RS06310	COG0765	amino acid transport
C5L38_RS06315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5L38_RS06320	COG1126	abc transporter atp-binding protein
C5L38_RS06335	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C5L38_RS06340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5L38_RS06360	COG1012	belongs to the aldehyde dehydrogenase family
C5L38_RS06385	COG3903	Transcriptional regulator
C5L38_RS06385	COG3629	intracellular signal transduction
C5L38_RS06395	COG1028	Short-chain dehydrogenase reductase Sdr
C5L38_RS06410	COG1940	carbohydrate kinase activity
C5L38_RS06415	COG1129	ABC transporter
C5L38_RS06430	COG0673	inositol 2-dehydrogenase activity
C5L38_RS06435	COG2197	response regulator
C5L38_RS06440	COG4585	Histidine kinase
C5L38_RS06460	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C5L38_RS06465	COG1028	Short-chain dehydrogenase reductase Sdr
C5L38_RS06470	COG4266	Belongs to the allantoicase family
C5L38_RS06475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C5L38_RS06480	COG1414	Transcriptional regulator
C5L38_RS06500	COG2197	response regulator
C5L38_RS06515	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C5L38_RS06530	COG4733	cellulase activity
C5L38_RS06530	COG5297	Belongs to the glycosyl hydrolase family 6
C5L38_RS06545	COG2233	PERMEase
C5L38_RS06555	COG2233	PERMEase
C5L38_RS06565	COG2351	hydroxyisourate hydrolase activity
C5L38_RS06585	COG3622	Belongs to the hyi family
C5L38_RS06590	COG2084	Dehydrogenase
C5L38_RS06595	COG0753	catalase activity
C5L38_RS06610	COG3960	tartronate-semialdehyde synthase activity
C5L38_RS06630	COG0318	PFAM AMP-dependent synthetase and ligase
C5L38_RS06635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5L38_RS06640	COG2197	response regulator
C5L38_RS06660	COG0346	lactoylglutathione lyase activity
C5L38_RS06665	COG0640	Transcriptional regulator
C5L38_RS06670	COG0583	DNA-binding transcription factor activity
C5L38_RS06675	COG0477	Major facilitator Superfamily
C5L38_RS06685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5L38_RS06695	COG0300	oxidoreductase activity
C5L38_RS06705	COG1960	acyl-CoA dehydrogenase activity
C5L38_RS06730	COG0475	glutathione-regulated potassium exporter activity
C5L38_RS06750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5L38_RS06765	COG1120	ATPase activity
C5L38_RS06770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5L38_RS06790	COG1028	Short-chain dehydrogenase reductase Sdr
C5L38_RS06795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5L38_RS06820	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C5L38_RS06840	COG2045	Belongs to the ComB family
C5L38_RS06845	COG2197	response regulator
C5L38_RS06855	COG1222	aaa ATPase
C5L38_RS06950	COG1960	acyl-CoA dehydrogenase activity
C5L38_RS06955	COG1309	transcriptional regulator
C5L38_RS06990	COG0789	Transcriptional regulator
C5L38_RS06995	COG0300	oxidoreductase activity
C5L38_RS07030	COG2252	PERMEase
C5L38_RS07035	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C5L38_RS07070	COG1802	Transcriptional regulator
C5L38_RS07090	COG0028	Belongs to the TPP enzyme family
C5L38_RS07100	COG1404	Belongs to the peptidase S8 family
C5L38_RS07125	COG1162	GTPase activity
C5L38_RS07155	COG1960	acyl-CoA dehydrogenase activity
C5L38_RS07180	COG0175	sulfate reduction
C5L38_RS07185	COG0529	Catalyzes the synthesis of activated sulfate
C5L38_RS07205	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C5L38_RS07210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5L38_RS07225	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
C5L38_RS07245	COG0142	geranyltranstransferase activity
C5L38_RS07270	COG0596	Alpha beta hydrolase
C5L38_RS07340	COG0346	lactoylglutathione lyase activity
C5L38_RS07350	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5L38_RS07400	COG2084	Dehydrogenase
C5L38_RS07405	COG1733	regulation of RNA biosynthetic process
C5L38_RS07410	COG1404	Belongs to the peptidase S8 family
C5L38_RS07425	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C5L38_RS07430	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C5L38_RS07460	COG2326	polyphosphate kinase activity
C5L38_RS07490	COG1116	anion transmembrane transporter activity
C5L38_RS07500	COG3220	belongs to the UPF0276 family
C5L38_RS07510	COG3253	May function as heme-dependent peroxidase
C5L38_RS07515	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C5L38_RS07525	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5L38_RS07530	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C5L38_RS07550	COG0183	Belongs to the thiolase family
C5L38_RS07555	COG1024	Enoyl-CoA hydratase
C5L38_RS07555	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5L38_RS07560	COG5434	Belongs to the glycosyl hydrolase 28 family
C5L38_RS07560	COG4632	Exopolysaccharide biosynthesis protein
C5L38_RS07570	COG2755	lipolytic protein G-D-S-L family
C5L38_RS07575	COG1215	transferase activity, transferring glycosyl groups
C5L38_RS07575	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C5L38_RS07590	COG1316	TRANSCRIPTIONal
C5L38_RS07600	COG0531	amino acid
C5L38_RS07605	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C5L38_RS07610	COG4214	carbohydrate transport
C5L38_RS07620	COG4213	ABC transporter substrate-binding protein
C5L38_RS07625	COG1940	carbohydrate kinase activity
C5L38_RS07630	COG0395	ABC-type sugar transport system, permease component
C5L38_RS07635	COG1175	transmembrane transport
C5L38_RS07640	COG1653	transport
C5L38_RS07650	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C5L38_RS07665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C5L38_RS07760	COG0318	PFAM AMP-dependent synthetase and ligase
C5L38_RS07785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5L38_RS07795	COG0673	inositol 2-dehydrogenase activity
C5L38_RS07815	COG0318	PFAM AMP-dependent synthetase and ligase
C5L38_RS07820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5L38_RS07825	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C5L38_RS07840	COG1024	Enoyl-CoA hydratase
C5L38_RS07845	COG0531	amino acid
C5L38_RS07850	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C5L38_RS07855	COG2235	arginine
C5L38_RS07865	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C5L38_RS07875	COG2040	homocysteine
C5L38_RS07900	COG1799	cell septum assembly
C5L38_RS07905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5L38_RS07910	COG1802	Transcriptional regulator
C5L38_RS07915	COG3938	Belongs to the proline racemase family
C5L38_RS07935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5L38_RS07970	COG2268	Band 7 protein
C5L38_RS07985	COG3851	Histidine kinase
C5L38_RS07990	COG2197	response regulator
C5L38_RS08040	COG0366	Alpha amylase catalytic
C5L38_RS08045	COG0395	ABC-type sugar transport system, permease component
C5L38_RS08050	COG1175	transmembrane transport
C5L38_RS08060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C5L38_RS08065	COG0531	amino acid
C5L38_RS08070	COG0569	domain protein
C5L38_RS08100	COG4591	ABC-type transport system involved in lipoprotein release permease component
C5L38_RS08100	COG1136	(ABC) transporter
C5L38_RS08110	COG0756	dUTP diphosphatase activity
C5L38_RS08135	COG2205	protein histidine kinase activity
C5L38_RS08140	COG0745	RESPONSE REGULATOR receiver
C5L38_RS08150	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C5L38_RS08180	COG3324	translation initiation factor activity
C5L38_RS08220	COG1435	thymidine kinase activity
C5L38_RS08235	COG1042	CoA-binding domain protein
C5L38_RS08235	COG0045	succinate-CoA ligase (ADP-forming) activity
C5L38_RS08235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5L38_RS08245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5L38_RS08250	COG1802	Transcriptional regulator
C5L38_RS08265	COG0612	Peptidase, M16
C5L38_RS08270	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C5L38_RS08280	COG3290	protein histidine kinase activity
C5L38_RS08285	COG4565	transcriptional regulatory protein
C5L38_RS08290	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5L38_RS08300	COG0187	DNA topoisomerase II activity
C5L38_RS08315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5L38_RS08320	COG1802	Transcriptional regulator
C5L38_RS08325	COG3842	ATPase activity
C5L38_RS08350	COG1793	dna ligase
C5L38_RS08355	COG0514	ATP-dependent DNA helicase (RecQ)
C5L38_RS08370	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C5L38_RS08395	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5L38_RS08400	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C5L38_RS08405	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C5L38_RS08450	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C5L38_RS08460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C5L38_RS08465	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C5L38_RS08475	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C5L38_RS08490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5L38_RS08500	COG0586	Pfam SNARE associated Golgi protein
C5L38_RS08505	COG4585	Histidine kinase
C5L38_RS08510	COG2197	response regulator
C5L38_RS08515	COG2358	TRAP transporter, solute receptor (TAXI family
C5L38_RS08520	COG2205	protein histidine kinase activity
C5L38_RS08525	COG0745	RESPONSE REGULATOR receiver
C5L38_RS08530	COG1126	abc transporter atp-binding protein
C5L38_RS08535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5L38_RS08540	COG0765	amino acid transport
C5L38_RS08545	COG0765	amino acid transport
C5L38_RS08550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5L38_RS08560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5L38_RS08570	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C5L38_RS08580	COG4585	Histidine kinase
C5L38_RS08585	COG2197	response regulator
C5L38_RS08590	COG1271	oxidase subunit
C5L38_RS08625	COG1917	Cupin 2, conserved barrel domain protein
C5L38_RS08625	COG2207	Transcriptional regulator
C5L38_RS08630	COG1201	RNA secondary structure unwinding
C5L38_RS08635	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C5L38_RS08645	COG0783	Belongs to the Dps family
C5L38_RS08650	COG1396	sequence-specific DNA binding
C5L38_RS08655	COG1546	Belongs to the CinA family
C5L38_RS08655	COG1058	Belongs to the CinA family
C5L38_RS08665	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5L38_RS08675	COG1674	ftsk spoiiie
C5L38_RS08685	COG4999	Histidine kinase
C5L38_RS08685	COG3850	Histidine kinase
C5L38_RS08685	COG3437	response regulator, receiver
C5L38_RS08685	COG2205	protein histidine kinase activity
C5L38_RS08690	COG2208	phosphoserine phosphatase activity
C5L38_RS08690	COG2770	Histidine kinase
C5L38_RS08720	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C5L38_RS08725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5L38_RS08730	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C5L38_RS08750	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C5L38_RS08755	COG0612	Peptidase, M16
C5L38_RS08760	COG1185	polyribonucleotide nucleotidyltransferase activity
C5L38_RS08765	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C5L38_RS08775	COG1674	ftsk spoiiie
C5L38_RS08820	COG1404	Belongs to the peptidase S8 family
C5L38_RS08840	COG1404	Belongs to the peptidase S8 family
C5L38_RS08845	COG3266	domain, Protein
C5L38_RS08865	COG0455	bacterial-type flagellum organization
C5L38_RS08870	COG4166	transmembrane transport
C5L38_RS08875	COG0601	transmembrane transport
C5L38_RS08885	COG0444	Belongs to the ABC transporter superfamily
C5L38_RS08890	COG4608	Belongs to the ABC transporter superfamily
C5L38_RS08905	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C5L38_RS08910	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C5L38_RS08920	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C5L38_RS08935	COG0779	Required for maturation of 30S ribosomal subunits
C5L38_RS08955	COG0330	HflC and HflK could
C5L38_RS08960	COG0442	prolyl-tRNA aminoacylation
C5L38_RS08975	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C5L38_RS08980	COG0750	zinc metalloprotease
C5L38_RS08985	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C5L38_RS08990	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C5L38_RS09000	COG1012	belongs to the aldehyde dehydrogenase family
C5L38_RS09005	COG0697	spore germination
C5L38_RS09015	COG2508	Transcriptional regulator
C5L38_RS09045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5L38_RS09055	COG1176	ABC-type spermidine putrescine transport system, permease component I
C5L38_RS09060	COG3842	ATPase activity
C5L38_RS09085	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C5L38_RS09090	COG0584	glycerophosphoryl diester phosphodiesterase
C5L38_RS09100	COG4585	Histidine kinase
C5L38_RS09105	COG2197	response regulator
C5L38_RS09130	COG1012	belongs to the aldehyde dehydrogenase family
C5L38_RS09140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C5L38_RS09145	COG1136	(ABC) transporter
C5L38_RS09165	COG3842	ATPase activity
C5L38_RS09170	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C5L38_RS09180	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C5L38_RS09185	COG0575	Belongs to the CDS family
C5L38_RS09190	COG0233	cytoplasmic translational termination
C5L38_RS09195	COG0528	UMP kinase activity
C5L38_RS09200	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C5L38_RS09205	COG0052	Belongs to the universal ribosomal protein uS2 family
C5L38_RS09225	COG1191	sigma factor activity
C5L38_RS09305	COG0792	nuclease activity
C5L38_RS09320	COG0681	Belongs to the peptidase S26 family
C5L38_RS09325	COG0681	Belongs to the peptidase S26 family
C5L38_RS09340	COG0335	large ribosomal subunit rRNA binding
C5L38_RS09345	COG0336	Belongs to the RNA methyltransferase TrmD family
C5L38_RS09350	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C5L38_RS09355	COG1837	Belongs to the UPF0109 family
C5L38_RS09360	COG0228	four-way junction DNA binding
C5L38_RS09375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C5L38_RS09385	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C5L38_RS09415	COG0477	Major facilitator Superfamily
C5L38_RS09420	COG1196	nuclear chromosome segregation
C5L38_RS09430	COG1254	Belongs to the acylphosphatase family
C5L38_RS09440	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C5L38_RS09445	COG0571	ribonuclease III activity
C5L38_RS09450	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C5L38_RS09465	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C5L38_RS09470	COG0742	ribosomal rna small subunit methyltransferase
C5L38_RS09475	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C5L38_RS09480	COG1461	Dihydroxyacetone kinase
C5L38_RS09485	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C5L38_RS09490	COG0351	phosphomethylpyrimidine kinase
C5L38_RS09510	COG1181	Belongs to the D-alanine--D-alanine ligase family
C5L38_RS09515	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C5L38_RS09525	COG1920	GTP binding
C5L38_RS09535	COG0776	regulation of translation
C5L38_RS09545	COG0066	3-isopropylmalate dehydratase activity
C5L38_RS09550	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C5L38_RS09555	COG1414	Transcriptional regulator
C5L38_RS09600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5L38_RS09605	COG0179	Fumarylacetoacetate (FAA) hydrolase
C5L38_RS09615	COG5002	protein histidine kinase activity
C5L38_RS09620	COG2018	Roadblock/LC7 domain
C5L38_RS09640	COG2018	Roadblock/LC7 domain
C5L38_RS09660	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5L38_RS09665	COG1470	cell adhesion involved in biofilm formation
C5L38_RS09665	COG0366	Alpha amylase catalytic
C5L38_RS09675	COG2353	YceI-like domain
C5L38_RS09685	COG0592	DNA-directed DNA polymerase activity
C5L38_RS09695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C5L38_RS09705	COG0477	Major facilitator Superfamily
C5L38_RS09720	COG2957	Belongs to the agmatine deiminase family
C5L38_RS09725	COG0804	urea catabolic process
C5L38_RS09730	COG0831	urea catabolic process
C5L38_RS09730	COG0832	Belongs to the urease beta subunit family
C5L38_RS09740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5L38_RS09745	COG0473	3-isopropylmalate dehydrogenase activity
C5L38_RS09750	COG1695	Transcriptional regulator
C5L38_RS09770	COG1012	belongs to the aldehyde dehydrogenase family
C5L38_RS09775	COG0506	proline dehydrogenase activity
C5L38_RS09780	COG3835	regulator
C5L38_RS09785	COG0667	Aldo Keto reductase
C5L38_RS09800	COG1116	anion transmembrane transporter activity
C5L38_RS09825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5L38_RS09830	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C5L38_RS09835	COG0440	acetolactate synthase activity
C5L38_RS09845	COG5001	Diguanylate cyclase
C5L38_RS09845	COG3300	MHYT domain
C5L38_RS09855	COG0667	Aldo Keto reductase
C5L38_RS09860	COG2133	pyrroloquinoline quinone binding
C5L38_RS09865	COG2197	response regulator
C5L38_RS09880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5L38_RS09885	COG2409	Drug exporters of the RND superfamily
C5L38_RS09900	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C5L38_RS09910	COG0154	amidase activity
C5L38_RS09915	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C5L38_RS09925	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C5L38_RS09935	COG4221	oxidoreductase activity
C5L38_RS09950	COG0482	sulfurtransferase activity
C5L38_RS09970	COG2860	membrane
C5L38_RS09975	COG4608	Belongs to the ABC transporter superfamily
C5L38_RS09980	COG0444	Belongs to the ABC transporter superfamily
C5L38_RS09985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5L38_RS09990	COG0601	transmembrane transport
C5L38_RS09995	COG0747	negative chemotaxis
C5L38_RS10015	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C5L38_RS10020	COG0509	glycine decarboxylation via glycine cleavage system
C5L38_RS10025	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C5L38_RS10030	COG1760	l-serine dehydratase
C5L38_RS10070	COG1376	ErfK ybiS ycfS ynhG family protein
C5L38_RS10085	COG2197	response regulator
C5L38_RS10090	COG4585	Histidine kinase
C5L38_RS10100	COG1131	(ABC) transporter
C5L38_RS10105	COG1132	(ABC) transporter
C5L38_RS10110	COG1132	(ABC) transporter
C5L38_RS10120	COG2197	response regulator
C5L38_RS10125	COG4585	Histidine kinase
C5L38_RS10155	COG0058	SHG alpha-glucan phosphorylase activity
C5L38_RS10160	COG0366	Alpha amylase catalytic
C5L38_RS10165	COG0366	Alpha amylase catalytic
C5L38_RS10175	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C5L38_RS10195	COG0789	Transcriptional regulator
C5L38_RS10200	COG1522	sequence-specific DNA binding
C5L38_RS10210	COG0667	Aldo Keto reductase
C5L38_RS10215	COG1301	dicarboxylic acid transport
C5L38_RS10225	COG4565	transcriptional regulatory protein
C5L38_RS10245	COG0205	6-phosphofructokinase activity
C5L38_RS10250	COG0857	belongs to the CobB CobQ family
C5L38_RS10250	COG0280	phosphate acetyltransferase
C5L38_RS10295	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C5L38_RS10295	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C5L38_RS10355	COG0183	Belongs to the thiolase family
C5L38_RS10410	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
C5L38_RS10425	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5L38_RS10440	COG4585	Histidine kinase
C5L38_RS10445	COG2197	response regulator
C5L38_RS10460	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C5L38_RS10465	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C5L38_RS10470	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C5L38_RS10475	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C5L38_RS10480	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C5L38_RS10485	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C5L38_RS10490	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C5L38_RS10510	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C5L38_RS10515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5L38_RS10525	COG2890	protein-(glutamine-N5) methyltransferase activity
C5L38_RS10530	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C5L38_RS10535	COG0254	rRNA binding
C5L38_RS10540	COG1316	TRANSCRIPTIONal
C5L38_RS10550	COG0083	homoserine kinase activity
C5L38_RS10555	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C5L38_RS10560	COG0460	homoserine dehydrogenase
C5L38_RS10565	COG0019	diaminopimelate decarboxylase activity
C5L38_RS10570	COG0018	arginyl-trna synthetase
C5L38_RS10570	COG0018	arginyl-trna synthetase
C5L38_RS10600	COG3467	pyridoxamine 5'-phosphate
C5L38_RS10615	COG2205	protein histidine kinase activity
C5L38_RS10620	COG0772	Belongs to the SEDS family
C5L38_RS10625	COG0768	penicillin binding
C5L38_RS10635	COG0789	Transcriptional regulator
C5L38_RS10715	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C5L38_RS10745	COG0745	RESPONSE REGULATOR receiver
C5L38_RS10750	COG2205	protein histidine kinase activity
C5L38_RS10755	COG0567	Dehydrogenase, E1 component
C5L38_RS10755	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5L38_RS10780	COG2255	four-way junction helicase activity
C5L38_RS10820	COG0604	alcohol dehydrogenase
C5L38_RS10835	COG0765	amino acid transport
C5L38_RS10840	COG1126	abc transporter atp-binding protein
C5L38_RS10845	COG4106	trans-aconitate 2-methyltransferase activity
C5L38_RS10880	COG5640	endopeptidase activity
C5L38_RS10900	COG0142	geranyltranstransferase activity
C5L38_RS10905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5L38_RS10915	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C5L38_RS10945	COG1597	lipid kinase activity
C5L38_RS10965	COG1028	Short-chain dehydrogenase reductase Sdr
C5L38_RS10970	COG0363	glucosamine-6-phosphate deaminase activity
C5L38_RS10975	COG1472	Belongs to the glycosyl hydrolase 3 family
C5L38_RS10980	COG0395	ABC-type sugar transport system, permease component
C5L38_RS10985	COG1175	transmembrane transport
C5L38_RS10990	COG2182	Extracellular solute-binding protein
C5L38_RS10995	COG2188	Transcriptional regulator
C5L38_RS11010	COG1215	transferase activity, transferring glycosyl groups
C5L38_RS11025	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5L38_RS11030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5L38_RS11035	COG1216	Glycosyl transferase, family 2
C5L38_RS11035	COG1442	glycosyl transferase family 8
C5L38_RS11050	COG0667	Aldo Keto reductase
C5L38_RS11080	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5L38_RS11090	COG0242	peptide deformylase activity
C5L38_RS11110	COG5662	AntiSigma factor
C5L38_RS11115	COG1595	DNA-templated transcription, initiation
C5L38_RS11125	COG2135	peptidase activity
C5L38_RS11135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C5L38_RS11145	COG2076	Multidrug Resistance protein
C5L38_RS11155	COG0483	inositol monophosphate 1-phosphatase activity
C5L38_RS11165	COG0753	catalase activity
C5L38_RS11190	COG1615	UPF0182 protein
C5L38_RS11200	COG3480	Lon protease (S16) C-terminal proteolytic domain
C5L38_RS11255	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C5L38_RS11295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5L38_RS11345	COG0477	Major facilitator Superfamily
C5L38_RS11350	COG2814	Major facilitator Superfamily
C5L38_RS11390	COG0601	transmembrane transport
C5L38_RS11395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5L38_RS11440	COG0513	Belongs to the DEAD box helicase family
C5L38_RS11445	COG0596	Alpha beta hydrolase
C5L38_RS11450	COG1432	Conserved Protein
C5L38_RS11460	COG2095	MarC family integral membrane protein
C5L38_RS11500	COG0598	Magnesium transport protein CorA
C5L38_RS11535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C5L38_RS11540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5L38_RS11550	COG1595	DNA-templated transcription, initiation
C5L38_RS11565	COG1024	Enoyl-CoA hydratase
C5L38_RS11570	COG0519	Catalyzes the synthesis of GMP from XMP
C5L38_RS11580	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C5L38_RS11585	COG1611	Belongs to the LOG family
C5L38_RS11590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5L38_RS11645	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C5L38_RS11670	COG0444	Belongs to the ABC transporter superfamily
C5L38_RS11675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5L38_RS11680	COG0601	transmembrane transport
C5L38_RS11690	COG4608	Belongs to the ABC transporter superfamily
C5L38_RS11700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5L38_RS11715	COG1217	gtp-binding protein TYPA
C5L38_RS11730	COG1842	Phage shock protein A
C5L38_RS11785	COG3903	Transcriptional regulator
C5L38_RS11785	COG3629	intracellular signal transduction
C5L38_RS11800	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C5L38_RS11825	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5L38_RS11840	COG0012	GTP binding
C5L38_RS11855	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C5L38_RS11865	COG1570	exodeoxyribonuclease VII activity
C5L38_RS11870	COG1722	exodeoxyribonuclease VII activity
C5L38_RS11875	COG0778	Nitroreductase
C5L38_RS11900	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C5L38_RS11900	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C5L38_RS11920	COG0346	lactoylglutathione lyase activity
C5L38_RS11940	COG0114	fumarate hydratase activity
C5L38_RS11955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5L38_RS11965	COG1136	(ABC) transporter
C5L38_RS11980	COG0450	alkyl hydroperoxide reductase
C5L38_RS11985	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5L38_RS12005	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C5L38_RS12010	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C5L38_RS12015	COG0667	Aldo Keto reductase
C5L38_RS12020	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C5L38_RS12055	COG3903	Transcriptional regulator
C5L38_RS12055	COG3629	intracellular signal transduction
C5L38_RS12060	COG2885	chlorophyll binding
C5L38_RS12105	COG2894	cell division
C5L38_RS12140	COG0251	oxidation-reduction process
C5L38_RS12145	COG1414	Transcriptional regulator
C5L38_RS12160	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C5L38_RS12200	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C5L38_RS12275	COG0438	transferase activity, transferring glycosyl groups
C5L38_RS12280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C5L38_RS12290	COG0728	peptidoglycan biosynthetic process
C5L38_RS12300	COG0438	transferase activity, transferring glycosyl groups
C5L38_RS12350	COG1331	Highly conserved protein containing a thioredoxin domain
C5L38_RS12365	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C5L38_RS12375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5L38_RS12380	COG0515	serine threonine protein kinase
C5L38_RS12380	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5L38_RS12385	COG0515	serine threonine protein kinase
C5L38_RS12385	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5L38_RS12400	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C5L38_RS12425	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C5L38_RS12440	COG1064	alcohol dehydrogenase
C5L38_RS12450	COG1376	ErfK ybiS ycfS ynhG family protein
C5L38_RS12465	COG2986	histidine ammonia-lyase
C5L38_RS12480	COG1024	Enoyl-CoA hydratase
C5L38_RS12495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5L38_RS12510	COG4249	Peptidase C14 caspase catalytic subunit p20
C5L38_RS12510	COG2319	Wd-40 repeat
C5L38_RS12515	COG0424	maF-like protein
C5L38_RS12525	COG4770	biotin carboxylase activity
C5L38_RS12535	COG1349	DNA-binding transcription factor activity
C5L38_RS12555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5L38_RS12585	COG1012	belongs to the aldehyde dehydrogenase family
C5L38_RS12590	COG1012	belongs to the aldehyde dehydrogenase family
C5L38_RS12605	COG1595	DNA-templated transcription, initiation
C5L38_RS12610	COG0745	RESPONSE REGULATOR receiver
C5L38_RS12615	COG2205	protein histidine kinase activity
C5L38_RS12640	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C5L38_RS12655	COG0583	DNA-binding transcription factor activity
C5L38_RS12660	COG2814	Major facilitator Superfamily
C5L38_RS12680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5L38_RS12700	COG1079	Belongs to the binding-protein-dependent transport system permease family
C5L38_RS12705	COG4603	Belongs to the binding-protein-dependent transport system permease family
C5L38_RS12710	COG3845	ABC transporter
C5L38_RS12715	COG1744	ABC transporter substrate-binding protein PnrA-like
C5L38_RS12720	COG1473	amidohydrolase
C5L38_RS12720	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C5L38_RS12730	COG2089	acid synthase
C5L38_RS12735	COG1083	cytidylyl-transferase
C5L38_RS12745	COG1216	Glycosyl transferase, family 2
C5L38_RS12775	COG1595	DNA-templated transcription, initiation
C5L38_RS12800	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C5L38_RS12810	COG2009	succinate dehydrogenase
C5L38_RS12820	COG1053	succinate dehydrogenase
C5L38_RS12825	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C5L38_RS12840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C5L38_RS12855	COG1309	transcriptional regulator
C5L38_RS12865	COG1408	metallophosphoesterase
C5L38_RS12940	COG1686	Belongs to the peptidase S11 family
C5L38_RS12945	COG1295	ribonuclease BN
C5L38_RS12965	COG0180	Tryptophanyl-tRNA synthetase
C5L38_RS12970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C5L38_RS12975	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5L38_RS12980	COG0726	polysaccharide deacetylase
C5L38_RS12985	COG0754	glutathionylspermidine amidase activity
C5L38_RS13055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5L38_RS13060	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5L38_RS13080	COG0039	L-malate dehydrogenase activity
C5L38_RS13095	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C5L38_RS13110	COG0138	bifunctional purine biosynthesis protein purh
C5L38_RS13140	COG0045	succinate-CoA ligase (ADP-forming) activity
C5L38_RS13150	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C5L38_RS13155	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C5L38_RS13160	COG0714	Associated with various cellular activities
C5L38_RS13180	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C5L38_RS13210	COG2197	response regulator
C5L38_RS13240	COG0519	Catalyzes the synthesis of GMP from XMP
C5L38_RS13240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C5L38_RS13255	COG1012	belongs to the aldehyde dehydrogenase family
C5L38_RS13260	COG0515	serine threonine protein kinase
C5L38_RS13275	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C5L38_RS13285	COG0516	GMP reductase activity
C5L38_RS13295	COG1595	DNA-templated transcription, initiation
C5L38_RS13300	COG2197	response regulator
C5L38_RS13310	COG0583	DNA-binding transcription factor activity
C5L38_RS13320	COG4221	oxidoreductase activity
C5L38_RS13340	COG1175	transmembrane transport
C5L38_RS13345	COG0395	ABC-type sugar transport system, permease component
C5L38_RS13350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5L38_RS13370	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C5L38_RS13375	COG0726	polysaccharide deacetylase
C5L38_RS13390	COG4941	Belongs to the sigma-70 factor family
C5L38_RS13400	COG0726	polysaccharide deacetylase
C5L38_RS13410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C5L38_RS13435	COG0802	atpase or kinase
C5L38_RS13445	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C5L38_RS13455	COG0736	holo-[acyl-carrier-protein] synthase activity
C5L38_RS13460	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C5L38_RS13470	COG1072	(Pantothenic acid kinase))
C5L38_RS13480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5L38_RS13485	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C5L38_RS13490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C5L38_RS13495	COG0488	(ABC) transporter
C5L38_RS13505	COG0101	tRNA pseudouridine synthase activity
C5L38_RS13510	COG0203	ribosomal protein L17
C5L38_RS13520	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C5L38_RS13525	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C5L38_RS13530	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C5L38_RS13535	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C5L38_RS13545	COG0563	adenylate kinase activity
C5L38_RS13555	COG0200	Binds to the 23S rRNA
C5L38_RS13560	COG1841	ribosomal large subunit assembly
C5L38_RS13565	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C5L38_RS13570	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C5L38_RS13575	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C5L38_RS13580	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C5L38_RS13590	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C5L38_RS13595	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C5L38_RS13600	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C5L38_RS13605	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C5L38_RS13610	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C5L38_RS13615	COG0255	Belongs to the universal ribosomal protein uL29 family
C5L38_RS13620	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C5L38_RS13625	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C5L38_RS13630	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C5L38_RS13635	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C5L38_RS13640	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C5L38_RS13645	COG0089	rRNA binding
C5L38_RS13650	COG0088	Forms part of the polypeptide exit tunnel
C5L38_RS13655	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C5L38_RS13660	COG0051	transcription antitermination factor activity, RNA binding
C5L38_RS13665	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C5L38_RS13675	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C5L38_RS13680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5L38_RS13685	COG0049	tRNA binding
C5L38_RS13690	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C5L38_RS13700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C5L38_RS13705	COG0085	RNA polymerase activity
C5L38_RS13715	COG0222	ribosome binding
C5L38_RS13720	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C5L38_RS13730	COG0081	regulation of translation
C5L38_RS13735	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C5L38_RS13745	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C5L38_RS13755	COG0436	Aminotransferase
C5L38_RS13760	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C5L38_RS13765	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C5L38_RS13775	COG2030	dehydratase
C5L38_RS13780	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C5L38_RS13800	COG0702	epimerase
C5L38_RS13810	COG1666	GTP binding
C5L38_RS13815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C5L38_RS13825	COG3304	Inner membrane component domain
C5L38_RS13830	COG0501	Belongs to the peptidase M48B family
C5L38_RS13835	COG1970	mechanosensitive ion channel activity
C5L38_RS13840	COG1007	ATP synthesis coupled electron transport
C5L38_RS13855	COG0713	ATP synthesis coupled electron transport
C5L38_RS13860	COG0839	Belongs to the complex I subunit 6 family
C5L38_RS13865	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5L38_RS13870	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C5L38_RS13875	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5L38_RS13880	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5L38_RS13885	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5L38_RS13905	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C5L38_RS13905	COG0674	pyruvate-flavodoxin oxidoreductase activity
C5L38_RS13910	COG1013	pyruvate-flavodoxin oxidoreductase activity
C5L38_RS13920	COG0515	serine threonine protein kinase
C5L38_RS13920	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5L38_RS13930	COG1733	regulation of RNA biosynthetic process
C5L38_RS13935	COG0702	epimerase
C5L38_RS13980	COG0142	geranyltranstransferase activity
C5L38_RS13995	COG0179	Fumarylacetoacetate (FAA) hydrolase
C5L38_RS14010	COG1007	ATP synthesis coupled electron transport
C5L38_RS14020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C5L38_RS14025	COG0713	ATP synthesis coupled electron transport
C5L38_RS14030	COG0839	Belongs to the complex I subunit 6 family
C5L38_RS14035	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5L38_RS14040	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C5L38_RS14045	COG1034	ATP synthesis coupled electron transport
C5L38_RS14050	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C5L38_RS14060	COG0649	NAD binding
C5L38_RS14065	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5L38_RS14070	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5L38_RS14095	COG2226	methyltransferase
C5L38_RS14105	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C5L38_RS14110	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C5L38_RS14120	COG1278	Cold shock
C5L38_RS14125	COG0739	heme binding
C5L38_RS14125	COG1196	nuclear chromosome segregation
C5L38_RS14125	COG0741	lytic transglycosylase activity
C5L38_RS14155	COG0546	phosphoglycolate phosphatase activity
C5L38_RS14165	COG1309	transcriptional regulator
C5L38_RS14170	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5L38_RS14170	COG0515	serine threonine protein kinase
C5L38_RS14175	COG2072	flavoprotein involved in K transport
C5L38_RS14190	COG1309	transcriptional regulator
C5L38_RS14260	COG1131	(ABC) transporter
C5L38_RS14320	COG2945	thiolester hydrolase activity
C5L38_RS14320	COG0596	Alpha beta hydrolase
C5L38_RS14335	COG4821	SIS domain
C5L38_RS14345	COG1733	regulation of RNA biosynthetic process
C5L38_RS14375	COG2197	response regulator
C5L38_RS14380	COG4585	Histidine kinase
C5L38_RS14395	COG0259	pyridoxamine-phosphate oxidase activity
C5L38_RS14420	COG0318	PFAM AMP-dependent synthetase and ligase
C5L38_RS14425	COG0789	Transcriptional regulator
C5L38_RS14430	COG0659	secondary active sulfate transmembrane transporter activity
C5L38_RS14455	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5L38_RS14510	COG0583	DNA-binding transcription factor activity
C5L38_RS14515	COG0277	FAD linked oxidase domain protein
C5L38_RS14520	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C5L38_RS14545	COG2267	carboxylic ester hydrolase activity
C5L38_RS14560	COG0667	Aldo Keto reductase
C5L38_RS14565	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C5L38_RS14595	COG2252	PERMEase
C5L38_RS14605	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C5L38_RS14650	COG2814	Major facilitator Superfamily
C5L38_RS14660	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C5L38_RS14665	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C5L38_RS14670	COG1278	Cold shock
C5L38_RS14700	COG1061	Type III restriction enzyme res subunit
C5L38_RS14715	COG3973	AAA domain
C5L38_RS14735	COG3142	Participates in the control of copper homeostasis
C5L38_RS14850	COG1737	Transcriptional regulator
C5L38_RS14855	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C5L38_RS14860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5L38_RS14860	COG1263	PTS System
C5L38_RS14900	COG0463	Glycosyl transferase, family 2
C5L38_RS14965	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C5L38_RS14995	COG2197	response regulator
C5L38_RS15040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5L38_RS15095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5L38_RS15145	COG4191	Histidine kinase
C5L38_RS15215	COG3842	ATPase activity
C5L38_RS15225	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C5L38_RS15235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5L38_RS15240	COG0215	cysteine-tRNA ligase activity
C5L38_RS15245	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C5L38_RS15250	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C5L38_RS15255	COG1329	Transcriptional regulator
C5L38_RS15275	COG5002	protein histidine kinase activity
C5L38_RS15290	COG2814	Major facilitator Superfamily
C5L38_RS15310	COG0588	phosphoglycerate mutase activity
C5L38_RS15320	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C5L38_RS15325	COG2207	Transcriptional regulator
C5L38_RS15335	COG0438	transferase activity, transferring glycosyl groups
C5L38_RS15370	COG2249	NAD(P)H dehydrogenase (quinone) activity
C5L38_RS15425	COG4552	Acetyltransferase involved in intracellular survival and related
C5L38_RS15435	COG1490	D-aminoacyl-tRNA deacylase activity
C5L38_RS15450	COG3485	protocatechuate 3,4-dioxygenase
C5L38_RS15480	COG2897	thiosulfate sulfurtransferase activity
C5L38_RS15500	COG0745	RESPONSE REGULATOR receiver
C5L38_RS15505	COG1609	Transcriptional regulator
C5L38_RS15510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5L38_RS15525	COG0823	Involved in the tonB-independent uptake of proteins
C5L38_RS15530	COG0737	Belongs to the 5'-nucleotidase family
C5L38_RS15535	COG0456	acetyltransferase
C5L38_RS15540	COG1725	Transcriptional regulator
C5L38_RS15545	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C5L38_RS15565	COG0494	nUDIX hydrolase
C5L38_RS15565	COG0406	alpha-ribazole phosphatase activity
C5L38_RS15575	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C5L38_RS15590	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C5L38_RS15595	COG0306	phosphate transporter
C5L38_RS15605	COG1937	Protein conserved in bacteria
C5L38_RS15620	COG0671	phosphoesterase, PA-phosphatase related
C5L38_RS15625	COG0741	lytic transglycosylase activity
C5L38_RS15625	COG1196	nuclear chromosome segregation
C5L38_RS15625	COG0739	heme binding
C5L38_RS15660	COG1846	Transcriptional regulator
C5L38_RS15695	COG1846	Transcriptional regulator
C5L38_RS15710	COG1252	NADH dehydrogenase
C5L38_RS15740	COG0579	oxidoreductase
C5L38_RS15745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C5L38_RS15755	COG0667	Aldo Keto reductase
C5L38_RS15770	COG0789	Transcriptional regulator
C5L38_RS15795	COG1597	lipid kinase activity
C5L38_RS15810	COG4585	Histidine kinase
C5L38_RS15815	COG2197	response regulator
C5L38_RS15825	COG0513	Belongs to the DEAD box helicase family
C5L38_RS15855	COG0785	Cytochrome C biogenesis protein
C5L38_RS15860	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C5L38_RS15860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C5L38_RS15870	COG1643	Atp-dependent helicase
C5L38_RS15895	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C5L38_RS15905	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C5L38_RS15935	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C5L38_RS15940	COG0047	phosphoribosylformylglycinamidine synthase activity
C5L38_RS15945	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C5L38_RS15980	COG2197	response regulator
C5L38_RS15990	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C5L38_RS16005	COG0151	Belongs to the GarS family
C5L38_RS16040	COG1136	(ABC) transporter
C5L38_RS16060	COG2095	MarC family integral membrane protein
C5L38_RS16075	COG1937	Protein conserved in bacteria
C5L38_RS16080	COG0655	NAD(P)H dehydrogenase (quinone) activity
C5L38_RS16095	COG2267	carboxylic ester hydrolase activity
C5L38_RS16115	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C5L38_RS16145	COG1191	sigma factor activity
C5L38_RS16150	COG1191	sigma factor activity
C5L38_RS16165	COG0477	Major facilitator Superfamily
C5L38_RS16175	COG0477	Major facilitator Superfamily
C5L38_RS16180	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C5L38_RS16190	COG2205	protein histidine kinase activity
C5L38_RS16195	COG0745	RESPONSE REGULATOR receiver
C5L38_RS16245	COG0784	Response regulator, receiver
C5L38_RS16250	COG0318	PFAM AMP-dependent synthetase and ligase
C5L38_RS16255	COG1595	DNA-templated transcription, initiation
C5L38_RS16265	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C5L38_RS16280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5L38_RS16295	COG0653	protein targeting
C5L38_RS16315	COG0006	proline dipeptidase activity
C5L38_RS16335	COG1999	signal sequence binding
C5L38_RS16350	COG2837	iron assimilation
C5L38_RS16360	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C5L38_RS16365	COG0561	phosphatase activity
C5L38_RS16375	COG2186	Transcriptional regulator
C5L38_RS16380	COG2807	transmembrane transport
C5L38_RS16400	COG1131	(ABC) transporter
C5L38_RS16415	COG0789	Transcriptional regulator
C5L38_RS16420	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
C5L38_RS16440	COG0561	phosphatase activity
C5L38_RS16450	COG4988	ABC transporter
C5L38_RS16455	COG1294	oxidase, subunit
C5L38_RS16460	COG1271	oxidase subunit
C5L38_RS16465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C5L38_RS16470	COG1609	Transcriptional regulator
C5L38_RS16475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C5L38_RS16485	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C5L38_RS16510	COG0662	Cupin 2, conserved barrel domain protein
C5L38_RS16515	COG1950	PFAM Membrane protein of
C5L38_RS16520	COG0626	cystathionine gamma-synthase activity
C5L38_RS16560	COG0305	Participates in initiation and elongation during chromosome replication
C5L38_RS16565	COG0534	Mate efflux family protein
C5L38_RS16570	COG0359	binds to the 23S rRNA
C5L38_RS16575	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C5L38_RS16580	COG0629	single-stranded DNA binding
C5L38_RS16585	COG0360	Binds together with S18 to 16S ribosomal RNA
C5L38_RS16610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5L38_RS16620	COG1260	myo-inositol-1-phosphate synthase
C5L38_RS16630	COG0617	tRNA 3'-terminal CCA addition
C5L38_RS16645	COG2815	serine threonine protein kinase
C5L38_RS16645	COG0515	serine threonine protein kinase
C5L38_RS16650	COG1595	DNA-templated transcription, initiation
C5L38_RS16660	COG0492	ferredoxin-NADP+ reductase activity
C5L38_RS16665	COG3118	belongs to the thioredoxin family
C5L38_RS16680	COG1192	Involved in chromosome partitioning
C5L38_RS16685	COG0357	Ribosomal RNA small subunit methyltransferase G
C5L38_RS16695	COG0706	membrane insertase activity
C5L38_RS16700	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C5L38_RS16725	COG0592	DNA-directed DNA polymerase activity
C5L38_RS16730	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C5L38_RS16735	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C5L38_RS16740	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C5L38_RS16750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C5L38_RS16775	COG0515	serine threonine protein kinase
C5L38_RS16810	COG0705	Rhomboid family
C5L38_RS16830	COG3764	Sortase (surface protein transpeptidase)
C5L38_RS16835	COG3764	Sortase (surface protein transpeptidase)
C5L38_RS16840	COG0515	serine threonine protein kinase
C5L38_RS16850	COG0768	penicillin binding
C5L38_RS16865	COG1716	ATPase activity
C5L38_RS16870	COG1716	ATPase activity
C5L38_RS16885	COG2197	response regulator
C5L38_RS16910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5L38_RS16915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5L38_RS16920	COG2151	metal-sulfur cluster biosynthetic enzyme
C5L38_RS16925	COG3396	Phenylacetate-CoA oxygenase
C5L38_RS16930	COG3460	Phenylacetate-CoA oxygenase
C5L38_RS16935	COG3396	Phenylacetate-CoA oxygenase
C5L38_RS16960	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5L38_RS16965	COG1309	transcriptional regulator
C5L38_RS16970	COG1522	sequence-specific DNA binding
C5L38_RS16985	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5L38_RS17000	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C5L38_RS17020	COG4591	ABC-type transport system involved in lipoprotein release permease component
C5L38_RS17020	COG1136	(ABC) transporter
C5L38_RS17040	COG0515	serine threonine protein kinase
C5L38_RS17045	COG0515	serine threonine protein kinase
C5L38_RS17070	COG0022	dehydrogenase e1 component
C5L38_RS17075	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5L38_RS17085	COG2271	Major facilitator Superfamily
C5L38_RS17100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5L38_RS17105	COG0626	cystathionine gamma-synthase activity
C5L38_RS17135	COG1362	aminopeptidase activity
C5L38_RS17140	COG1960	acyl-CoA dehydrogenase activity
C5L38_RS17150	COG1741	Belongs to the pirin family
C5L38_RS17165	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C5L38_RS17255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5L38_RS17260	COG0745	RESPONSE REGULATOR receiver
C5L38_RS17265	COG2205	protein histidine kinase activity
C5L38_RS17290	COG1289	transmembrane transporter activity
C5L38_RS17320	COG0596	Alpha beta hydrolase
C5L38_RS17355	COG0431	NADPH-dependent FMN reductase
C5L38_RS17360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5L38_RS17375	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
C5L38_RS17415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5L38_RS17450	COG0513	Belongs to the DEAD box helicase family
C5L38_RS17455	COG1278	Cold shock
C5L38_RS17460	COG2226	methyltransferase
C5L38_RS17465	COG0076	glutamate decarboxylase activity
C5L38_RS17515	COG0596	Alpha beta hydrolase
C5L38_RS17515	COG2945	thiolester hydrolase activity
C5L38_RS17635	COG1720	tRNA m6t6A37 methyltransferase activity
C5L38_RS17645	COG0717	Belongs to the dCTP deaminase family
C5L38_RS17660	COG2181	nitrate reductase activity
C5L38_RS17660	COG0247	lactate metabolic process
C5L38_RS17670	COG0443	Heat shock 70 kDa protein
C5L38_RS17675	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C5L38_RS17680	COG0484	heat shock protein binding
C5L38_RS17685	COG0789	Transcriptional regulator
C5L38_RS17715	COG0542	response to heat
C5L38_RS17745	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C5L38_RS17765	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C5L38_RS17770	COG0191	fructose-bisphosphate aldolase activity
C5L38_RS17775	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C5L38_RS17795	COG3844	kynureninase activity
C5L38_RS17805	COG4585	Histidine kinase
C5L38_RS17810	COG2197	response regulator
C5L38_RS17815	COG2124	cytochrome p450
C5L38_RS17825	COG0640	Transcriptional regulator
C5L38_RS17835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5L38_RS17840	COG1247	-acetyltransferase
C5L38_RS17850	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C5L38_RS17860	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C5L38_RS17865	COG0604	alcohol dehydrogenase
C5L38_RS17870	COG1660	Displays ATPase and GTPase activities
C5L38_RS17905	COG0693	protein deglycase activity
C5L38_RS17910	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C5L38_RS17915	COG1802	Transcriptional regulator
C5L38_RS17930	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C5L38_RS17935	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C5L38_RS17950	COG1595	DNA-templated transcription, initiation
C5L38_RS17990	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C5L38_RS18000	COG2815	serine threonine protein kinase
C5L38_RS18000	COG0515	serine threonine protein kinase
C5L38_RS18015	COG1408	metallophosphoesterase
C5L38_RS18025	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C5L38_RS18035	COG0003	Pfam Anion-transporting ATPase
C5L38_RS18055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5L38_RS18090	COG2267	carboxylic ester hydrolase activity
C5L38_RS18100	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C5L38_RS18105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5L38_RS18170	COG1205	dead DEAH box helicase
C5L38_RS18170	COG1111	helicase
C5L38_RS18175	COG1366	Belongs to the anti-sigma-factor antagonist family
C5L38_RS18185	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C5L38_RS18195	COG2890	protein-(glutamine-N5) methyltransferase activity
C5L38_RS18205	COG1754	DNA topoisomerase type I activity
C5L38_RS18205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C5L38_RS18210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C5L38_RS18215	COG0470	DNA polymerase III
C5L38_RS18305	COG0105	UTP biosynthetic process
C5L38_RS18335	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
C5L38_RS18340	COG0732	type I restriction modification DNA specificity domain
C5L38_RS18345	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C5L38_RS18355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5L38_RS18365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5L38_RS18370	COG2197	response regulator
C5L38_RS18385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5L38_RS18405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5L38_RS18415	COG3629	intracellular signal transduction
C5L38_RS18465	COG0252	asparaginase activity
C5L38_RS18490	COG0367	asparagine synthase
C5L38_RS18545	COG1595	DNA-templated transcription, initiation
C5L38_RS18555	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5L38_RS18555	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5L38_RS18570	COG1289	transmembrane transporter activity
C5L38_RS18590	COG1012	belongs to the aldehyde dehydrogenase family
C5L38_RS18595	COG2318	DinB family
C5L38_RS18620	COG0393	Putative heavy-metal-binding
C5L38_RS18625	COG0586	Pfam SNARE associated Golgi protein
C5L38_RS18635	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C5L38_RS18640	COG2027	D-alanyl-D-alanine carboxypeptidase
C5L38_RS18655	COG0037	tRNA processing
C5L38_RS18670	COG0302	gtp cyclohydrolase
C5L38_RS18680	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C5L38_RS18685	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C5L38_RS18700	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C5L38_RS18700	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C5L38_RS18715	COG1174	glycine betaine transport
C5L38_RS18725	COG1732	Glycine betaine
C5L38_RS18740	COG0649	NAD binding
C5L38_RS18760	COG2197	response regulator
C5L38_RS18775	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C5L38_RS18785	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C5L38_RS18790	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C5L38_RS18800	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C5L38_RS18820	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C5L38_RS18850	COG0739	heme binding
C5L38_RS18865	COG2205	protein histidine kinase activity
C5L38_RS18870	COG0745	RESPONSE REGULATOR receiver
C5L38_RS18880	COG1595	DNA-templated transcription, initiation
C5L38_RS18885	COG1194	a g-specific adenine glycosylase
C5L38_RS18900	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C5L38_RS18920	COG0248	Ppx GppA phosphatase
C5L38_RS18925	COG1082	Xylose isomerase domain protein TIM barrel
C5L38_RS18935	COG0129	dihydroxy-acid dehydratase activity
C5L38_RS18940	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5L38_RS18940	COG0515	serine threonine protein kinase
C5L38_RS18955	COG1131	(ABC) transporter
C5L38_RS18965	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C5L38_RS18970	COG1335	isochorismatase
C5L38_RS19000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5L38_RS19010	COG0123	including yeast histone deacetylase and acetoin utilization protein
C5L38_RS19060	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C5L38_RS19065	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C5L38_RS19070	COG0181	hydroxymethylbilane synthase activity
C5L38_RS19075	COG1648	precorrin-2 dehydrogenase activity
C5L38_RS19075	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C5L38_RS19080	COG0113	porphobilinogen synthase activity
C5L38_RS19100	COG0018	arginyl-trna synthetase
C5L38_RS19105	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
C5L38_RS19125	COG1690	Belongs to the RtcB family
C5L38_RS19170	COG0789	Transcriptional regulator
C5L38_RS19185	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C5L38_RS19190	COG0406	alpha-ribazole phosphatase activity
C5L38_RS19205	COG0785	Cytochrome C biogenesis protein
C5L38_RS19210	COG1333	cytochrome c biogenesis protein
C5L38_RS19215	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C5L38_RS19270	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C5L38_RS19280	COG0163	prenyltransferase activity
C5L38_RS19290	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C5L38_RS19295	COG3708	Transcriptional regulator
C5L38_RS19295	COG2207	Transcriptional regulator
C5L38_RS19310	COG1301	dicarboxylic acid transport
C5L38_RS19315	COG1309	transcriptional regulator
C5L38_RS19325	COG0259	pyridoxamine-phosphate oxidase activity
C5L38_RS19330	COG1309	transcriptional regulator
C5L38_RS19395	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C5L38_RS19420	COG1686	Belongs to the peptidase S11 family
C5L38_RS19460	COG1487	ribonuclease activity
C5L38_RS19495	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C5L38_RS19505	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C5L38_RS19530	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C5L38_RS19570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5L38_RS19585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5L38_RS19640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5L38_RS19670	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C5L38_RS19715	COG0367	asparagine synthase
C5L38_RS19720	COG4555	ABC transporter
C5L38_RS19760	COG1846	Transcriptional regulator
C5L38_RS19765	COG3384	dioxygenase
C5L38_RS19780	COG0477	Major facilitator Superfamily
C5L38_RS19790	COG3191	aminopeptidase activity
C5L38_RS19805	COG0243	molybdopterin cofactor binding
C5L38_RS19830	COG1970	mechanosensitive ion channel activity
C5L38_RS19850	COG3263	regulation of cellular component size
C5L38_RS19860	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C5L38_RS19865	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C5L38_RS19875	COG0315	cyclic pyranopterin monophosphate synthase activity
C5L38_RS19880	COG0521	Mo-molybdopterin cofactor biosynthetic process
C5L38_RS19885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5L38_RS19925	COG2072	flavoprotein involved in K transport
C5L38_RS19930	COG2267	carboxylic ester hydrolase activity
C5L38_RS19935	COG1028	Short-chain dehydrogenase reductase Sdr
C5L38_RS19950	COG0793	Belongs to the peptidase S41A family
C5L38_RS19950	COG4946	Tricorn protease homolog
C5L38_RS19960	COG2409	Drug exporters of the RND superfamily
C5L38_RS19970	COG0310	cobalt ion transport
C5L38_RS19980	COG1122	ATPase activity
C5L38_RS19995	COG1280	lysine exporter protein (LysE YggA)
C5L38_RS20020	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C5L38_RS20025	COG2188	Transcriptional regulator
C5L38_RS20035	COG0442	prolyl-tRNA aminoacylation
C5L38_RS20065	COG0084	hydrolase, TatD family'
C5L38_RS20075	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C5L38_RS20080	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C5L38_RS20105	COG0488	(ABC) transporter
C5L38_RS20135	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C5L38_RS20140	COG2197	response regulator
C5L38_RS20145	COG1846	Transcriptional regulator
C5L38_RS20150	COG4106	trans-aconitate 2-methyltransferase activity
C5L38_RS20170	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C5L38_RS20185	COG0193	aminoacyl-tRNA hydrolase activity
C5L38_RS20190	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C5L38_RS20195	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C5L38_RS20200	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C5L38_RS20215	COG4585	Histidine kinase
C5L38_RS20255	COG0477	Major facilitator Superfamily
C5L38_RS20260	COG1136	(ABC) transporter
C5L38_RS20265	COG0577	efflux transmembrane transporter activity
C5L38_RS20345	COG0545	Peptidyl-prolyl cis-trans isomerase
C5L38_RS20430	COG0148	phosphopyruvate hydratase activity
C5L38_RS20450	COG1252	NADH dehydrogenase
C5L38_RS20455	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C5L38_RS20460	COG1136	(ABC) transporter
C5L38_RS20460	COG0577	efflux transmembrane transporter activity
C5L38_RS20465	COG1136	(ABC) transporter
C5L38_RS20495	COG0183	Belongs to the thiolase family
C5L38_RS20500	COG2755	lipolytic protein G-D-S-L family
C5L38_RS20545	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C5L38_RS20560	COG1228	amidohydrolase
C5L38_RS20595	COG0463	Glycosyl transferase, family 2
C5L38_RS20595	COG1216	Glycosyl transferase, family 2
C5L38_RS20625	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5L38_RS20630	COG1191	sigma factor activity
C5L38_RS20635	COG1366	Belongs to the anti-sigma-factor antagonist family
C5L38_RS20645	COG3104	oligopeptide transport
C5L38_RS20650	COG0745	RESPONSE REGULATOR receiver
C5L38_RS20655	COG2205	protein histidine kinase activity
C5L38_RS20690	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C5L38_RS20700	COG1316	TRANSCRIPTIONal
C5L38_RS20705	COG1607	acyl-coa hydrolase
C5L38_RS20710	COG1316	TRANSCRIPTIONal
C5L38_RS20755	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
C5L38_RS20755	COG0778	Nitroreductase
C5L38_RS20760	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C5L38_RS20800	COG2835	tetraacyldisaccharide 4'-kinase activity
C5L38_RS20810	COG1482	cell wall glycoprotein biosynthetic process
C5L38_RS20820	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C5L38_RS20865	COG0714	Associated with various cellular activities
C5L38_RS20885	COG0745	RESPONSE REGULATOR receiver
C5L38_RS20890	COG5002	protein histidine kinase activity
C5L38_RS20890	COG5000	phosphorelay sensor kinase activity
C5L38_RS20895	COG0823	Involved in the tonB-independent uptake of proteins
C5L38_RS20905	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C5L38_RS20910	COG2197	response regulator
C5L38_RS20915	COG3214	Protein conserved in bacteria
C5L38_RS20925	COG0653	protein targeting
C5L38_RS20955	COG2902	Dehydrogenase
C5L38_RS20965	COG1388	LysM domain
C5L38_RS20965	COG1134	teichoic acid transport
C5L38_RS20975	COG1309	transcriptional regulator
C5L38_RS20980	COG0395	ABC-type sugar transport system, permease component
C5L38_RS20985	COG1175	transmembrane transport
C5L38_RS20990	COG1653	transport
C5L38_RS21000	COG0515	serine threonine protein kinase
C5L38_RS21005	COG0515	serine threonine protein kinase
C5L38_RS21010	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C5L38_RS21025	COG2884	Cell division ATP-binding protein ftsE
C5L38_RS21035	COG0793	Belongs to the peptidase S41A family
C5L38_RS21040	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C5L38_RS21055	COG0583	DNA-binding transcription factor activity
C5L38_RS21060	COG2223	nitrite transmembrane transporter activity
C5L38_RS21075	COG3973	AAA domain
C5L38_RS21075	COG3973	AAA domain
C5L38_RS21085	COG0776	regulation of translation
C5L38_RS21090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C5L38_RS21095	COG1678	Uncharacterized ACR, COG1678
C5L38_RS21115	COG1175	transmembrane transport
C5L38_RS21120	COG0395	ABC-type sugar transport system, permease component
C5L38_RS21125	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C5L38_RS21140	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C5L38_RS21285	COG3654	unkown
C5L38_RS21325	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C5L38_RS21335	COG0277	FAD linked oxidase domain protein
C5L38_RS21370	COG1335	isochorismatase
C5L38_RS21380	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C5L38_RS21390	COG1113	amino acid transport
C5L38_RS21400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5L38_RS21405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5L38_RS21410	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C5L38_RS21430	COG1234	tRNA 3'-trailer cleavage
C5L38_RS21435	COG1263	PTS System
C5L38_RS21440	COG1263	PTS System
C5L38_RS21445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5L38_RS21450	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C5L38_RS21460	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C5L38_RS21480	COG0477	Major facilitator Superfamily
C5L38_RS21505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5L38_RS21520	COG4555	ABC transporter
C5L38_RS21525	COG2733	membrane
C5L38_RS21590	COG0706	membrane insertase activity
C5L38_RS21595	COG0179	Fumarylacetoacetate (FAA) hydrolase
C5L38_RS21610	COG4702	Belongs to the UPF0303 family
C5L38_RS21615	COG0673	inositol 2-dehydrogenase activity
C5L38_RS21620	COG1940	carbohydrate kinase activity
C5L38_RS21630	COG2188	Transcriptional regulator
C5L38_RS21700	COG3397	chitin binding
C5L38_RS21715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5L38_RS21780	COG0406	alpha-ribazole phosphatase activity
C5L38_RS21805	COG0745	RESPONSE REGULATOR receiver
C5L38_RS21815	COG3469	chitinase activity
C5L38_RS21825	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C5L38_RS21830	COG4977	sequence-specific DNA binding
C5L38_RS21840	COG0589	response to stress
C5L38_RS21850	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C5L38_RS21880	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C5L38_RS21895	COG1960	acyl-CoA dehydrogenase activity
C5L38_RS21910	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5L38_RS21915	COG1309	transcriptional regulator
C5L38_RS21930	COG1946	Acyl-CoA thioesterase
C5L38_RS22010	COG1472	Belongs to the glycosyl hydrolase 3 family
C5L38_RS22015	COG0583	DNA-binding transcription factor activity
C5L38_RS22040	COG1335	isochorismatase
C5L38_RS22045	COG0309	Hydrogenase expression formation protein (HypE)
C5L38_RS22050	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C5L38_RS22065	COG0477	Major facilitator Superfamily
C5L38_RS22080	COG1181	Belongs to the D-alanine--D-alanine ligase family
C5L38_RS22090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5L38_RS22100	COG2197	response regulator
C5L38_RS22105	COG4585	Histidine kinase
C5L38_RS22120	COG1609	Transcriptional regulator
C5L38_RS22125	COG0673	inositol 2-dehydrogenase activity
C5L38_RS22145	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C5L38_RS22170	COG2409	Drug exporters of the RND superfamily
C5L38_RS22185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5L38_RS22190	COG3718	enzyme involved in inositol metabolism
C5L38_RS22195	COG3962	Belongs to the TPP enzyme family
C5L38_RS22205	COG0456	acetyltransferase
C5L38_RS22205	COG0454	-acetyltransferase
C5L38_RS22255	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C5L38_RS22260	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C5L38_RS22265	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C5L38_RS22290	COG0583	DNA-binding transcription factor activity
C5L38_RS22300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5L38_RS22325	COG0629	single-stranded DNA binding
C5L38_RS22350	COG1136	(ABC) transporter
C5L38_RS22350	COG0577	efflux transmembrane transporter activity
C5L38_RS22365	COG2346	COG2346, Truncated hemoglobins
C5L38_RS22395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5L38_RS22410	COG1486	melibiose metabolic process
C5L38_RS22415	COG0395	ABC-type sugar transport system, permease component
C5L38_RS22420	COG1175	transmembrane transport
C5L38_RS22425	COG1653	transport
C5L38_RS22435	COG0668	transmembrane transport
C5L38_RS22445	COG3291	Pkd domain containing protein
C5L38_RS22445	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C5L38_RS22465	COG1846	Transcriptional regulator
C5L38_RS22470	COG0697	spore germination
C5L38_RS22480	COG4266	Belongs to the allantoicase family
C5L38_RS22505	COG2514	catechol 2,3-dioxygenase activity
C5L38_RS22540	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C5L38_RS22545	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C5L38_RS22550	COG1113	amino acid transport
C5L38_RS22555	COG1113	amino acid transport
C5L38_RS22560	COG1268	BioY protein
C5L38_RS22580	COG4552	Acetyltransferase involved in intracellular survival and related
C5L38_RS22590	COG3594	Acyltransferase
C5L38_RS22610	COG0544	peptidyl-prolyl cis-trans isomerase activity
C5L38_RS22615	COG0740	serine-type endopeptidase activity
C5L38_RS22620	COG0740	serine-type endopeptidase activity
C5L38_RS22625	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C5L38_RS22635	COG0525	valine-tRNA ligase activity
C5L38_RS22645	COG0285	dihydrofolate synthase activity
C5L38_RS22655	COG0105	UTP biosynthetic process
C5L38_RS22660	COG1077	Cell shape determining protein MreB Mrl
C5L38_RS22675	COG0768	penicillin binding
C5L38_RS22680	COG0772	Belongs to the SEDS family
C5L38_RS22705	COG1530	ribonuclease E activity
C5L38_RS22710	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C5L38_RS22715	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C5L38_RS22720	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C5L38_RS22735	COG0438	transferase activity, transferring glycosyl groups
C5L38_RS22740	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C5L38_RS22750	COG0463	Glycosyl transferase, family 2
C5L38_RS22760	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C5L38_RS22770	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C5L38_RS22785	COG0501	Belongs to the peptidase M48B family
C5L38_RS22795	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C5L38_RS22805	COG0799	negative regulation of ribosome biogenesis
C5L38_RS22810	COG0588	phosphoglycerate mutase activity
C5L38_RS22840	COG0495	leucyl-tRNA aminoacylation
C5L38_RS22850	COG1307	EDD domain protein, DegV family
C5L38_RS22855	COG1555	photosystem II stabilization
C5L38_RS22855	COG1596	polysaccharide export
C5L38_RS22870	COG2353	YceI-like domain
C5L38_RS22885	COG0268	Binds directly to 16S ribosomal RNA
C5L38_RS22890	COG0481	GTPase activity
C5L38_RS22915	COG1420	regulation of RNA biosynthetic process
C5L38_RS22920	COG0484	heat shock protein binding
C5L38_RS22940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C5L38_RS22950	COG0537	adenosine 5'-monophosphoramidase activity
C5L38_RS22955	COG1234	tRNA 3'-trailer cleavage
C5L38_RS22960	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C5L38_RS22970	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C5L38_RS22970	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C5L38_RS22980	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C5L38_RS22990	COG2315	Protein conserved in bacteria
C5L38_RS23000	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C5L38_RS23015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C5L38_RS23060	COG1381	Involved in DNA repair and RecF pathway recombination
C5L38_RS23065	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C5L38_RS23080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5L38_RS23090	COG0803	Belongs to the bacterial solute-binding protein 9 family
C5L38_RS23090	COG3443	Belongs to the bacterial solute-binding protein 9 family
C5L38_RS23095	COG0423	glycine-tRNA ligase activity
C5L38_RS23105	COG0667	Aldo Keto reductase
C5L38_RS23120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5L38_RS23120	COG0574	Belongs to the PEP-utilizing enzyme family
C5L38_RS23150	COG1028	Short-chain dehydrogenase reductase Sdr
C5L38_RS23155	COG1309	transcriptional regulator
C5L38_RS23160	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5L38_RS23160	COG2146	nitrite reductase [NAD(P)H] activity
C5L38_RS23165	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5L38_RS23165	COG2146	nitrite reductase [NAD(P)H] activity
C5L38_RS23170	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5L38_RS23175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5L38_RS23175	COG1017	nitric oxide dioxygenase activity
C5L38_RS23215	COG0243	molybdopterin cofactor binding
C5L38_RS23220	COG2949	membrane
C5L38_RS23240	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C5L38_RS23250	COG0358	DNA primase activity
C5L38_RS23255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5L38_RS23275	COG1070	Carbohydrate kinase
C5L38_RS23345	COG0681	Belongs to the peptidase S26 family
C5L38_RS23365	COG1764	response to oxidative stress
C5L38_RS23370	COG1846	Transcriptional regulator
C5L38_RS23390	COG0477	Major facilitator Superfamily
C5L38_RS23395	COG0318	PFAM AMP-dependent synthetase and ligase
C5L38_RS23425	COG2130	NADP-dependent
C5L38_RS23430	COG1764	response to oxidative stress
C5L38_RS23460	COG1309	transcriptional regulator
C5L38_RS23480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5L38_RS23485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5L38_RS23490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5L38_RS23535	COG0745	RESPONSE REGULATOR receiver
C5L38_RS23540	COG2205	protein histidine kinase activity
C5L38_RS23555	COG0789	Transcriptional regulator
C5L38_RS23560	COG0667	Aldo Keto reductase
C5L38_RS23575	COG2197	response regulator
C5L38_RS23580	COG4585	Histidine kinase
C5L38_RS23595	COG1309	transcriptional regulator
C5L38_RS23600	COG0477	Major facilitator Superfamily
C5L38_RS23610	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C5L38_RS23655	COG1358	cellular component organization or biogenesis
C5L38_RS23710	COG1234	tRNA 3'-trailer cleavage
C5L38_RS23775	COG4122	O-methyltransferase activity
C5L38_RS23795	COG3845	ABC transporter
C5L38_RS23820	COG1309	transcriptional regulator
C5L38_RS23825	COG0438	transferase activity, transferring glycosyl groups
C5L38_RS23850	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5L38_RS23920	COG0596	Alpha beta hydrolase
C5L38_RS23925	COG2197	response regulator
C5L38_RS23935	COG2030	dehydratase
C5L38_RS23945	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C5L38_RS23965	COG0800	Aldolase
C5L38_RS23970	COG3022	response to hydroperoxide
C5L38_RS24015	COG3540	Alkaline phosphatase
C5L38_RS24025	COG2814	Major facilitator Superfamily
C5L38_RS24045	COG1834	amidinotransferase
C5L38_RS24065	COG0672	)-iron permease
C5L38_RS24115	COG1994	Peptidase M50
C5L38_RS24135	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C5L38_RS24145	COG2814	Major facilitator Superfamily
C5L38_RS24150	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C5L38_RS24150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5L38_RS24160	COG2267	carboxylic ester hydrolase activity
C5L38_RS24185	COG0174	glutamine synthetase
C5L38_RS24190	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C5L38_RS24260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5L38_RS24290	COG2188	Transcriptional regulator
C5L38_RS24330	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C5L38_RS24340	COG0531	amino acid
C5L38_RS24355	COG1609	Transcriptional regulator
C5L38_RS24360	COG2182	Extracellular solute-binding protein
C5L38_RS24370	COG0395	ABC-type sugar transport system, permease component
C5L38_RS24375	COG0366	Alpha amylase catalytic
C5L38_RS24395	COG1309	transcriptional regulator
C5L38_RS24415	COG2365	Tyrosine phosphatase family
C5L38_RS24440	COG0745	RESPONSE REGULATOR receiver
C5L38_RS24495	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C5L38_RS24500	COG0321	lipoyl(octanoyl) transferase activity
C5L38_RS24530	COG1028	Short-chain dehydrogenase reductase Sdr
C5L38_RS24540	COG1028	Short-chain dehydrogenase reductase Sdr
C5L38_RS24550	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C5L38_RS24560	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5L38_RS24565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5L38_RS24570	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C5L38_RS24605	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C5L38_RS24620	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C5L38_RS24620	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C5L38_RS24625	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C5L38_RS24640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5L38_RS24645	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C5L38_RS24665	COG4585	Histidine kinase
C5L38_RS24670	COG2197	response regulator
C5L38_RS24675	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C5L38_RS24700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5L38_RS24710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C5L38_RS24715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C5L38_RS24725	COG1376	ErfK ybiS ycfS ynhG family protein
C5L38_RS24735	COG1845	cytochrome c oxidase, subunit III
C5L38_RS24740	COG2010	Cytochrome c
C5L38_RS24745	COG0723	plastoquinol--plastocyanin reductase activity
C5L38_RS24750	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C5L38_RS24755	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C5L38_RS24760	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5L38_RS24770	COG0705	Rhomboid family
C5L38_RS24805	COG0438	transferase activity, transferring glycosyl groups
C5L38_RS24825	COG0003	Pfam Anion-transporting ATPase
C5L38_RS24835	COG1940	carbohydrate kinase activity
C5L38_RS24860	COG4585	Histidine kinase
C5L38_RS24865	COG2197	response regulator
C5L38_RS24870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5L38_RS24885	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C5L38_RS24890	COG0243	molybdopterin cofactor binding
C5L38_RS24895	COG2193	ferroxidase activity
C5L38_RS24900	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C5L38_RS24905	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C5L38_RS24910	COG2815	serine threonine protein kinase
C5L38_RS24910	COG0515	serine threonine protein kinase
C5L38_RS24915	COG2022	thiamine diphosphate biosynthetic process
C5L38_RS24925	COG2022	thiamine diphosphate biosynthetic process
C5L38_RS24925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5L38_RS24940	COG0352	thiamine-phosphate diphosphorylase activity
C5L38_RS24965	COG1309	transcriptional regulator
C5L38_RS24970	COG1511	domain protein
C5L38_RS24975	COG1131	(ABC) transporter
C5L38_RS24985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C5L38_RS25005	COG0714	Associated with various cellular activities
C5L38_RS25015	COG0275	rRNA processing
C5L38_RS25025	COG0768	penicillin binding
C5L38_RS25030	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C5L38_RS25040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C5L38_RS25045	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C5L38_RS25055	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C5L38_RS25060	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C5L38_RS25070	COG1496	oxidoreductase activity
C5L38_RS25080	COG1799	cell septum assembly
C5L38_RS25095	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C5L38_RS25105	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C5L38_RS25155	COG0587	DNA-directed DNA polymerase activity
C5L38_RS25160	COG1432	Conserved Protein
C5L38_RS25180	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C5L38_RS25200	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C5L38_RS25205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C5L38_RS25210	COG0131	Imidazoleglycerol-phosphate dehydratase
C5L38_RS25215	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C5L38_RS25220	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C5L38_RS25225	COG0251	oxidation-reduction process
C5L38_RS25230	COG0107	imidazoleglycerol-phosphate synthase activity
C5L38_RS25250	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C5L38_RS25275	COG0134	indole-3-glycerol-phosphate synthase activity
C5L38_RS25285	COG0133	tryptophan synthase activity
C5L38_RS25290	COG0159	tryptophan synthase activity
C5L38_RS25300	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C5L38_RS25310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5L38_RS25315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5L38_RS25335	COG1397	ADP-ribosylglycohydrolase
C5L38_RS25345	COG0067	glutamate synthase
C5L38_RS25345	COG0070	glutamate synthase
C5L38_RS25345	COG0069	glutamate synthase activity
C5L38_RS25385	COG1917	Cupin 2, conserved barrel domain protein
C5L38_RS25385	COG4977	sequence-specific DNA binding
C5L38_RS25390	COG0287	Prephenate dehydrogenase
C5L38_RS25390	COG1605	Chorismate mutase
C5L38_RS25410	COG0737	Belongs to the 5'-nucleotidase family
C5L38_RS25420	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C5L38_RS25470	COG2050	protein possibly involved in aromatic compounds catabolism
C5L38_RS25500	COG1643	Atp-dependent helicase
C5L38_RS25505	COG2226	methyltransferase
C5L38_RS25520	COG0237	dephospho-CoA kinase activity
C5L38_RS25540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5L38_RS25565	COG0436	Aminotransferase
C5L38_RS25570	COG1733	regulation of RNA biosynthetic process
C5L38_RS25595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5L38_RS25600	COG2313	pseudouridylate synthase activity
C5L38_RS25610	COG0477	Major facilitator Superfamily
C5L38_RS25625	COG0556	nucleotide-excision repair
C5L38_RS25645	COG0477	Major facilitator Superfamily
C5L38_RS25660	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C5L38_RS25690	COG1660	Displays ATPase and GTPase activities
C5L38_RS25695	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C5L38_RS25700	COG1481	regulation of sporulation
C5L38_RS25710	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C5L38_RS25715	COG0126	phosphoglycerate kinase activity
C5L38_RS25720	COG0149	triose-phosphate isomerase activity
C5L38_RS25725	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C5L38_RS25735	COG0166	Belongs to the GPI family
C5L38_RS25750	COG0363	glucosamine-6-phosphate deaminase activity
C5L38_RS25765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C5L38_RS25775	COG0109	protoheme IX farnesyltransferase activity
C5L38_RS25795	COG1131	(ABC) transporter
C5L38_RS25810	COG0719	Fe-S assembly protein
C5L38_RS25820	COG0396	ATPase activity
C5L38_RS25825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5L38_RS25830	COG0822	iron-sulfur transferase activity
C5L38_RS25835	COG2151	metal-sulfur cluster biosynthetic enzyme
C5L38_RS25850	COG2076	Multidrug Resistance protein
C5L38_RS25855	COG3226	Transcriptional regulator
C5L38_RS25860	COG2171	N-acyltransferase activity
C5L38_RS25875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5L38_RS25910	COG1028	Short-chain dehydrogenase reductase Sdr
C5L38_RS25920	COG3290	protein histidine kinase activity
C5L38_RS25935	COG0768	penicillin binding
C5L38_RS25945	COG2197	response regulator
C5L38_RS25950	COG4585	Histidine kinase
C5L38_RS25975	COG3973	AAA domain
C5L38_RS25995	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C5L38_RS26015	COG2375	cellular response to nickel ion
C5L38_RS26015	COG1132	(ABC) transporter
C5L38_RS26035	COG1797	cobyrinic acid a,c-diamide synthase activity
C5L38_RS26050	COG1492	cobalamin metabolic process
C5L38_RS26055	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C5L38_RS26090	COG0488	(ABC) transporter
C5L38_RS26100	COG1024	Enoyl-CoA hydratase
C5L38_RS26140	COG3387	PFAM Glycoside hydrolase 15-related
C5L38_RS26155	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C5L38_RS26180	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5L38_RS26195	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5L38_RS26200	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C5L38_RS26215	COG2261	transglycosylase associated protein
C5L38_RS26220	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C5L38_RS26235	COG1028	Short-chain dehydrogenase reductase Sdr
C5L38_RS26250	COG2186	Transcriptional regulator
C5L38_RS26270	COG3830	Belongs to the UPF0237 family
C5L38_RS26270	COG0560	Phosphoserine phosphatase
C5L38_RS26275	COG0842	Transport permease protein
C5L38_RS26275	COG1716	ATPase activity
C5L38_RS26275	COG1131	(ABC) transporter
C5L38_RS26285	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C5L38_RS26290	COG4221	oxidoreductase activity
C5L38_RS26300	COG2197	response regulator
C5L38_RS26315	COG1119	ATPase activity
C5L38_RS26340	COG1881	PFAM PEBP family protein
C5L38_RS26350	COG2094	Belongs to the DNA glycosylase MPG family
C5L38_RS26385	COG0647	UMP catabolic process
C5L38_RS26390	COG1120	ATPase activity
C5L38_RS26410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C5L38_RS26415	COG0497	DNA recombination
C5L38_RS26425	COG0297	glycogen (starch) synthase activity
C5L38_RS26440	COG2197	response regulator
C5L38_RS26450	COG1136	(ABC) transporter
C5L38_RS26450	COG0577	efflux transmembrane transporter activity
C5L38_RS26460	COG3387	PFAM Glycoside hydrolase 15-related
C5L38_RS26465	COG0504	CTP synthase activity
C5L38_RS26470	COG0494	nUDIX hydrolase
C5L38_RS26480	COG0686	Belongs to the AlaDH PNT family
C5L38_RS26495	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C5L38_RS26500	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C5L38_RS26505	COG1187	pseudouridine synthase activity
C5L38_RS26510	COG3201	nicotinamide mononucleotide transporter
C5L38_RS26550	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C5L38_RS26560	COG1160	GTP binding
C5L38_RS26575	COG3583	domain protein
C5L38_RS26580	COG0438	transferase activity, transferring glycosyl groups
C5L38_RS26595	COG0671	phosphoesterase, PA-phosphatase related
C5L38_RS26600	COG0477	Major facilitator Superfamily
C5L38_RS26605	COG1799	cell septum assembly
C5L38_RS26625	COG0765	amino acid transport
C5L38_RS26635	COG1126	abc transporter atp-binding protein
C5L38_RS26665	COG4565	transcriptional regulatory protein
C5L38_RS26700	COG1725	Transcriptional regulator
C5L38_RS26710	COG0726	polysaccharide deacetylase
C5L38_RS26725	COG2755	lipolytic protein G-D-S-L family
C5L38_RS26730	COG2815	serine threonine protein kinase
C5L38_RS26730	COG0515	serine threonine protein kinase
C5L38_RS26740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5L38_RS26750	COG2188	Transcriptional regulator
C5L38_RS26755	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C5L38_RS26775	COG1309	transcriptional regulator
C5L38_RS26785	COG2072	flavoprotein involved in K transport
C5L38_RS26790	COG0243	molybdopterin cofactor binding
C5L38_RS26795	COG2851	Citrate transporter
C5L38_RS26825	COG1309	transcriptional regulator
C5L38_RS26835	COG0747	negative chemotaxis
C5L38_RS26840	COG1404	Belongs to the peptidase S8 family
C5L38_RS26845	COG4566	intracellular signal transduction
C5L38_RS26875	COG1960	acyl-CoA dehydrogenase activity
C5L38_RS26920	COG3876	Protein conserved in bacteria
C5L38_RS26960	COG2149	membrane
C5L38_RS26965	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C5L38_RS26995	COG3265	gluconokinase activity
C5L38_RS27000	COG2186	Transcriptional regulator
C5L38_RS27005	COG1113	amino acid transport
C5L38_RS27020	COG0564	pseudouridine synthase activity
C5L38_RS27030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5L38_RS27060	COG0667	Aldo Keto reductase
C5L38_RS27065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5L38_RS27075	COG0598	Magnesium transport protein CorA
C5L38_RS27095	COG0215	cysteine-tRNA ligase activity
C5L38_RS27105	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C5L38_RS27110	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C5L38_RS27115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C5L38_RS27120	COG1414	Transcriptional regulator
C5L38_RS27125	COG1410	methionine synthase
C5L38_RS27125	COG0646	methionine synthase
C5L38_RS27135	COG0747	negative chemotaxis
C5L38_RS27145	COG2197	response regulator
C5L38_RS27155	COG1994	Peptidase M50
C5L38_RS27155	COG0517	IMP dehydrogenase activity
C5L38_RS27175	COG1222	aaa ATPase
C5L38_RS27180	COG4122	O-methyltransferase activity
C5L38_RS27190	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C5L38_RS27195	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C5L38_RS27200	COG1609	Transcriptional regulator
C5L38_RS27210	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C5L38_RS27225	COG2378	regulation of single-species biofilm formation
C5L38_RS27245	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C5L38_RS27250	COG0805	protein transport
C5L38_RS27265	COG2124	cytochrome p450
C5L38_RS27300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5L38_RS27350	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C5L38_RS27355	COG1113	amino acid transport
C5L38_RS27365	COG0174	glutamine synthetase
C5L38_RS27370	COG1012	belongs to the aldehyde dehydrogenase family
C5L38_RS27405	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C5L38_RS27410	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C5L38_RS27415	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C5L38_RS27420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5L38_RS27430	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C5L38_RS27435	COG0072	phenylalanine-tRNA ligase activity
C5L38_RS27435	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5L38_RS27465	COG1051	belongs to the nudix hydrolase family
C5L38_RS27475	COG1649	PFAM Uncharacterised BCR, COG1649
C5L38_RS27485	COG0697	spore germination
C5L38_RS27505	COG2813	Specifically methylates the guanine in position
C5L38_RS27510	COG0137	argininosuccinate synthase activity
C5L38_RS27520	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C5L38_RS27525	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C5L38_RS27530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C5L38_RS27535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5L38_RS27540	COG1438	arginine binding
C5L38_RS27555	COG0165	Argininosuccinate lyase
C5L38_RS27570	COG0477	Major facilitator Superfamily
C5L38_RS27575	COG0204	Acyl-transferase
C5L38_RS27575	COG0318	PFAM AMP-dependent synthetase and ligase
C5L38_RS27610	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C5L38_RS27615	COG2011	ABC-type metal ion transport system permease component
C5L38_RS27620	COG1464	Belongs to the NlpA lipoprotein family
C5L38_RS27635	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C5L38_RS27640	COG1648	precorrin-2 dehydrogenase activity
C5L38_RS27640	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C5L38_RS27690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C5L38_RS27695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5L38_RS27700	COG0456	acetyltransferase
C5L38_RS27700	COG0454	-acetyltransferase
C5L38_RS27755	COG5002	protein histidine kinase activity
C5L38_RS27755	COG2176	DNA-directed DNA polymerase activity
C5L38_RS27770	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C5L38_RS27795	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C5L38_RS27800	COG1560	Kdo2-lipid A biosynthetic process
C5L38_RS27805	COG0438	transferase activity, transferring glycosyl groups
C5L38_RS27815	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C5L38_RS27820	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C5L38_RS27825	COG0217	transcriptional regulatory protein
C5L38_RS27830	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C5L38_RS27835	COG0632	four-way junction helicase activity
C5L38_RS27840	COG2255	four-way junction helicase activity
C5L38_RS27850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5L38_RS27855	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5L38_RS27860	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C5L38_RS27865	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C5L38_RS27870	COG1196	nuclear chromosome segregation
C5L38_RS27885	COG0124	histidyl-tRNA synthetase
C5L38_RS27905	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C5L38_RS27925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C5L38_RS27930	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C5L38_RS27940	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C5L38_RS27945	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C5L38_RS27955	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C5L38_RS27960	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C5L38_RS27965	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C5L38_RS27970	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C5L38_RS27985	COG0006	proline dipeptidase activity
C5L38_RS27990	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C5L38_RS27995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C5L38_RS28005	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C5L38_RS28010	COG0540	Belongs to the ATCase OTCase family
C5L38_RS28015	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C5L38_RS28025	COG0505	Belongs to the CarA family
C5L38_RS28030	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C5L38_RS28035	COG0167	dihydroorotate dehydrogenase activity
C5L38_RS28040	COG0284	orotidine-5'-phosphate decarboxylase activity
C5L38_RS28050	COG0194	GDP metabolic process
C5L38_RS28065	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C5L38_RS28080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C5L38_RS28100	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C5L38_RS28105	COG2390	Transcriptional regulator
C5L38_RS28115	COG2732	(Barnase) inhibitor
C5L38_RS28135	COG0531	amino acid
C5L38_RS28150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5L38_RS28165	COG2233	PERMEase
C5L38_RS28175	COG1846	Transcriptional regulator
C5L38_RS28175	COG1940	carbohydrate kinase activity
C5L38_RS28195	COG3201	nicotinamide mononucleotide transporter
C5L38_RS28200	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5L38_RS28200	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5L38_RS28205	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C5L38_RS28210	COG0140	phosphoribosyl-ATP diphosphatase activity
C5L38_RS28215	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C5L38_RS28240	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C5L38_RS28240	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C5L38_RS28260	COG1960	acyl-CoA dehydrogenase activity
C5L38_RS28285	COG1216	Glycosyl transferase, family 2
C5L38_RS28300	COG2270	Major facilitator Superfamily
C5L38_RS28310	COG2364	Membrane
C5L38_RS28315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5L38_RS28345	COG0438	transferase activity, transferring glycosyl groups
C5L38_RS28355	COG1984	allophanate hydrolase subunit 2
C5L38_RS28360	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C5L38_RS28365	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C5L38_RS28405	COG2018	Roadblock/LC7 domain
C5L38_RS28420	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C5L38_RS28425	COG2816	NAD+ diphosphatase activity
C5L38_RS28435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5L38_RS28460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5L38_RS28495	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C5L38_RS28535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C5L38_RS28545	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C5L38_RS28545	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C5L38_RS28595	COG1695	Transcriptional regulator
C5L38_RS28630	COG0697	spore germination
C5L38_RS28635	COG0583	DNA-binding transcription factor activity
C5L38_RS28690	COG1595	DNA-templated transcription, initiation
C5L38_RS28695	COG2409	Drug exporters of the RND superfamily
C5L38_RS28700	COG1846	Transcriptional regulator
C5L38_RS28705	COG0702	epimerase
C5L38_RS28770	COG0604	alcohol dehydrogenase
C5L38_RS28770	COG3321	synthase
C5L38_RS28825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5L38_RS28835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5L38_RS28840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5L38_RS28865	COG0604	alcohol dehydrogenase
C5L38_RS28865	COG3321	synthase
C5L38_RS28890	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C5L38_RS28950	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C5L38_RS28965	COG2318	DinB family
C5L38_RS28985	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C5L38_RS28990	COG1968	undecaprenyl-diphosphatase activity
C5L38_RS29035	COG0110	maltose O-acetyltransferase activity
C5L38_RS29045	COG1832	CoA-binding protein
C5L38_RS29050	COG1739	Uncharacterized protein family UPF0029
C5L38_RS29055	COG0420	3'-5' exonuclease activity
C5L38_RS29060	COG0419	ATPase involved in DNA repair
C5L38_RS29065	COG1522	sequence-specific DNA binding
C5L38_RS29080	COG0626	cystathionine gamma-synthase activity
C5L38_RS29120	COG0523	cobalamin synthesis protein
C5L38_RS29125	COG1132	(ABC) transporter
C5L38_RS29155	COG1120	ATPase activity
C5L38_RS29160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5L38_RS29180	COG1121	(ABC) transporter
C5L38_RS29185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5L38_RS29195	COG0803	Belongs to the bacterial solute-binding protein 9 family
C5L38_RS29205	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C5L38_RS29210	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C5L38_RS29225	COG1595	DNA-templated transcription, initiation
C5L38_RS29235	COG2188	Transcriptional regulator
C5L38_RS29240	COG1940	carbohydrate kinase activity
C5L38_RS29245	COG3663	DNA glycosylase
C5L38_RS29250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C5L38_RS29280	COG2226	methyltransferase
C5L38_RS29285	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C5L38_RS29290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C5L38_RS29295	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C5L38_RS29320	COG0740	serine-type endopeptidase activity
C5L38_RS29330	COG0831	urea catabolic process
C5L38_RS29335	COG0832	Belongs to the urease beta subunit family
C5L38_RS29340	COG0804	urea catabolic process
C5L38_RS29345	COG0830	nickel cation binding
C5L38_RS29350	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C5L38_RS29355	COG0829	nickel cation binding
C5L38_RS29370	COG0204	Acyl-transferase
C5L38_RS29390	COG0205	6-phosphofructokinase activity
C5L38_RS29395	COG3442	glutamine amidotransferase
C5L38_RS29405	COG0242	peptide deformylase activity
C5L38_RS29415	COG1960	acyl-CoA dehydrogenase activity
C5L38_RS29460	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5L38_RS29515	COG2890	protein-(glutamine-N5) methyltransferase activity
C5L38_RS29520	COG0386	Belongs to the glutathione peroxidase family
C5L38_RS29535	COG1946	Acyl-CoA thioesterase
C5L38_RS29550	COG1132	(ABC) transporter
C5L38_RS29555	COG1132	(ABC) transporter
C5L38_RS29560	COG0673	inositol 2-dehydrogenase activity
C5L38_RS29565	COG0277	FAD linked oxidase domain protein
C5L38_RS29575	COG1132	(ABC) transporter
C5L38_RS29580	COG2072	flavoprotein involved in K transport
C5L38_RS29605	COG4044	May play a role in the intracellular transport of hydrophobic ligands
C5L38_RS29610	COG1505	serine-type exopeptidase activity
C5L38_RS29620	COG0006	proline dipeptidase activity
C5L38_RS29655	COG3585	molybdate ion transport
C5L38_RS29675	COG2706	6-phosphogluconolactonase activity
C5L38_RS29685	COG2971	BadF BadG BcrA BcrD
C5L38_RS29690	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C5L38_RS29700	COG1902	pentaerythritol trinitrate reductase activity
C5L38_RS29705	COG0640	Transcriptional regulator
C5L38_RS29725	COG0671	phosphoesterase, PA-phosphatase related
C5L38_RS29785	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C5L38_RS29810	COG1660	Displays ATPase and GTPase activities
C5L38_RS29815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5L38_RS29845	COG2223	nitrite transmembrane transporter activity
C5L38_RS29850	COG1940	carbohydrate kinase activity
C5L38_RS29890	COG1349	DNA-binding transcription factor activity
C5L38_RS29900	COG0464	growth
C5L38_RS29920	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C5L38_RS29945	COG1028	Short-chain dehydrogenase reductase Sdr
C5L38_RS29965	COG1404	Belongs to the peptidase S8 family
C5L38_RS29985	COG0583	DNA-binding transcription factor activity
C5L38_RS29990	COG0183	Belongs to the thiolase family
C5L38_RS30000	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C5L38_RS30005	COG1396	sequence-specific DNA binding
C5L38_RS30025	COG1454	alcohol dehydrogenase
C5L38_RS30030	COG3485	protocatechuate 3,4-dioxygenase
C5L38_RS30070	COG4935	Belongs to the peptidase S8 family
C5L38_RS30070	COG2234	aminopeptidase activity
C5L38_RS30130	COG4221	oxidoreductase activity
C5L38_RS30140	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C5L38_RS30155	COG2182	Extracellular solute-binding protein
C5L38_RS30160	COG1175	transmembrane transport
C5L38_RS30165	COG0395	ABC-type sugar transport system, permease component
C5L38_RS30170	COG2723	6-phospho-beta-galactosidase activity
C5L38_RS30240	COG2867	negative regulation of translational initiation
C5L38_RS30270	COG0477	Major facilitator Superfamily
C5L38_RS30330	COG2188	Transcriptional regulator
C5L38_RS30340	COG1175	transmembrane transport
C5L38_RS30345	COG0395	ABC-type sugar transport system, permease component
C5L38_RS30395	COG5002	protein histidine kinase activity
C5L38_RS30395	COG2205	protein histidine kinase activity
C5L38_RS30395	COG0784	Response regulator, receiver
C5L38_RS30405	COG1366	Belongs to the anti-sigma-factor antagonist family
C5L38_RS30430	COG1191	sigma factor activity
C5L38_RS30450	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C5L38_RS30460	COG0574	Belongs to the PEP-utilizing enzyme family
C5L38_RS30460	COG3848	Pyruvate phosphate dikinase
C5L38_RS30470	COG2340	Cysteine-rich secretory protein family
C5L38_RS30480	COG2271	Major facilitator Superfamily
C5L38_RS30485	COG1535	isochorismatase
C5L38_RS30485	COG3433	isochorismatase activity
C5L38_RS30490	COG1021	2,3-dihydroxybenzoate-AMP ligase
C5L38_RS30495	COG1169	isochorismate synthase
C5L38_RS30500	COG1028	Short-chain dehydrogenase reductase Sdr
C5L38_RS30505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5L38_RS30515	COG0477	Major facilitator Superfamily
C5L38_RS30520	COG1535	isochorismatase
C5L38_RS30520	COG3433	isochorismatase activity
C5L38_RS30535	COG4753	response regulator
C5L38_RS30535	COG2207	Transcriptional regulator
C5L38_RS30540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5L38_RS30545	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5L38_RS30550	COG1120	ATPase activity
C5L38_RS30570	COG0154	amidase activity
C5L38_RS30580	COG1120	ATPase activity
C5L38_RS30595	COG1846	Transcriptional regulator
C5L38_RS30605	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C5L38_RS30610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5L38_RS30615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5L38_RS30620	COG1132	(ABC) transporter
C5L38_RS30625	COG1132	(ABC) transporter
C5L38_RS30630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5L38_RS30635	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5L38_RS30640	COG1120	ATPase activity
C5L38_RS30655	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5L38_RS30660	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C5L38_RS30665	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C5L38_RS30670	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C5L38_RS30685	COG3655	Transcriptional regulator
C5L38_RS30710	COG2890	protein-(glutamine-N5) methyltransferase activity
C5L38_RS30720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5L38_RS30735	COG0243	molybdopterin cofactor binding
C5L38_RS30745	COG3835	regulator
C5L38_RS30760	COG3903	Transcriptional regulator
C5L38_RS30760	COG3629	intracellular signal transduction
C5L38_RS30775	COG0513	Belongs to the DEAD box helicase family
C5L38_RS30780	COG1278	Cold shock
C5L38_RS30785	COG3739	integral membrane protein
C5L38_RS30795	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5L38_RS30820	COG2838	Isocitrate dehydrogenase
C5L38_RS30870	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C5L38_RS30875	COG1686	Belongs to the peptidase S11 family
C5L38_RS30890	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C5L38_RS30890	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5L38_RS30935	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5L38_RS30935	COG1902	pentaerythritol trinitrate reductase activity
C5L38_RS30945	COG1461	Dihydroxyacetone kinase
C5L38_RS30950	COG2376	Dihydroxyacetone kinase
C5L38_RS30955	COG0789	Transcriptional regulator
C5L38_RS30960	COG1742	UPF0060 membrane protein
C5L38_RS30990	COG4981	capsule polysaccharide biosynthetic process
C5L38_RS31020	COG0318	PFAM AMP-dependent synthetase and ligase
C5L38_RS31050	COG0475	glutathione-regulated potassium exporter activity
C5L38_RS31050	COG0569	domain protein
C5L38_RS31060	COG2197	response regulator
C5L38_RS31110	COG2205	protein histidine kinase activity
C5L38_RS31110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5L38_RS31120	COG2172	sigma factor antagonist activity
C5L38_RS31125	COG1366	Belongs to the anti-sigma-factor antagonist family
C5L38_RS31130	COG1366	Belongs to the anti-sigma-factor antagonist family
C5L38_RS31165	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C5L38_RS31180	COG0516	GMP reductase activity
C5L38_RS31180	COG0517	IMP dehydrogenase activity
C5L38_RS31210	COG1960	acyl-CoA dehydrogenase activity
C5L38_RS31240	COG0842	Transport permease protein
C5L38_RS31240	COG1131	(ABC) transporter
C5L38_RS31240	COG1716	ATPase activity
C5L38_RS31245	COG1309	transcriptional regulator
C5L38_RS31295	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C5L38_RS31300	COG1937	Protein conserved in bacteria
C5L38_RS31310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5L38_RS31315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5L38_RS31315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5L38_RS31325	COG0517	IMP dehydrogenase activity
C5L38_RS31325	COG0516	GMP reductase activity
C5L38_RS31330	COG1063	alcohol dehydrogenase
C5L38_RS31335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5L38_RS31350	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C5L38_RS31380	COG0515	serine threonine protein kinase
C5L38_RS31390	COG1063	alcohol dehydrogenase
C5L38_RS31395	COG0156	8-amino-7-oxononanoate synthase activity
C5L38_RS31400	COG0583	DNA-binding transcription factor activity
C5L38_RS31405	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5L38_RS31415	COG0387	Pfam Sodium calcium exchanger
C5L38_RS31420	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
C5L38_RS31425	COG0318	PFAM AMP-dependent synthetase and ligase
C5L38_RS31435	COG1846	Transcriptional regulator
C5L38_RS31450	COG1357	PFAM Pentapeptide repeats (8 copies)
C5L38_RS31515	COG3152	Membrane
C5L38_RS31540	COG0747	negative chemotaxis
C5L38_RS31545	COG0601	transmembrane transport
C5L38_RS31550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5L38_RS31560	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C5L38_RS31635	COG0659	secondary active sulfate transmembrane transporter activity
C5L38_RS31650	COG1191	sigma factor activity
C5L38_RS31655	COG5285	phytanoyl-CoA dioxygenase
C5L38_RS31670	COG0456	acetyltransferase
C5L38_RS31675	COG2356	endonuclease I
C5L38_RS31685	COG0252	asparaginase activity
C5L38_RS31735	COG0328	RNA-DNA hybrid ribonuclease activity
C5L38_RS31745	COG1024	Enoyl-CoA hydratase
C5L38_RS31750	COG2066	Belongs to the glutaminase family
C5L38_RS31770	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5L38_RS31770	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5L38_RS31800	COG0784	Response regulator, receiver
C5L38_RS31805	COG4251	negative regulation of phosphorylation
C5L38_RS31810	COG0745	RESPONSE REGULATOR receiver
C5L38_RS31830	COG0546	phosphoglycolate phosphatase activity
C5L38_RS31850	COG2814	Major facilitator Superfamily
C5L38_RS31910	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C5L38_RS31915	COG0714	Associated with various cellular activities
C5L38_RS31945	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C5L38_RS31955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5L38_RS31965	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C5L38_RS32010	COG2814	Major facilitator Superfamily
C5L38_RS32060	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C5L38_RS32070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5L38_RS32085	COG0515	serine threonine protein kinase
C5L38_RS32105	COG3251	PFAM MbtH domain protein
C5L38_RS32110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5L38_RS32150	COG1028	Short-chain dehydrogenase reductase Sdr
C5L38_RS32155	COG0697	spore germination
C5L38_RS32160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C5L38_RS32170	COG2267	carboxylic ester hydrolase activity
C5L38_RS32195	COG0671	phosphoesterase, PA-phosphatase related
C5L38_RS32225	COG2326	polyphosphate kinase activity
C5L38_RS32240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5L38_RS32300	COG2197	response regulator
C5L38_RS32310	COG0586	Pfam SNARE associated Golgi protein
C5L38_RS32360	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5L38_RS32365	COG0488	(ABC) transporter
C5L38_RS32395	COG3864	Putative metallopeptidase domain
C5L38_RS32400	COG0714	Associated with various cellular activities
C5L38_RS32445	COG0667	Aldo Keto reductase
C5L38_RS32510	COG2249	NAD(P)H dehydrogenase (quinone) activity
C5L38_RS32515	COG3619	membrane
C5L38_RS32560	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C5L38_RS32615	COG0488	(ABC) transporter
C5L38_RS32620	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C5L38_RS32655	COG0736	holo-[acyl-carrier-protein] synthase activity
C5L38_RS32710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5L38_RS32725	COG0745	RESPONSE REGULATOR receiver
C5L38_RS32730	COG2205	protein histidine kinase activity
C5L38_RS32800	COG1309	transcriptional regulator
C5L38_RS32825	COG0604	alcohol dehydrogenase
C5L38_RS32845	COG1846	Transcriptional regulator
C5L38_RS32850	COG1295	ribonuclease BN
C5L38_RS32850	COG1959	2 iron, 2 sulfur cluster binding
C5L38_RS32860	COG0515	serine threonine protein kinase
C5L38_RS32860	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5L38_RS32870	COG0300	oxidoreductase activity
C5L38_RS32885	COG3629	intracellular signal transduction
C5L38_RS32885	COG3903	Transcriptional regulator
C5L38_RS32980	COG2197	response regulator
C5L38_RS32985	COG0577	efflux transmembrane transporter activity
C5L38_RS32985	COG1136	(ABC) transporter
C5L38_RS33010	COG0776	regulation of translation
C5L38_RS33015	COG1278	Cold shock
C5L38_RS33055	COG2208	phosphoserine phosphatase activity
C5L38_RS33140	COG1595	DNA-templated transcription, initiation
C5L38_RS33190	COG0515	serine threonine protein kinase
C5L38_RS33205	COG0477	Major facilitator Superfamily
C5L38_RS33210	COG1366	Belongs to the anti-sigma-factor antagonist family
C5L38_RS33240	COG2964	Protein conserved in bacteria
C5L38_RS33280	COG0300	oxidoreductase activity
C5L38_RS33335	COG0464	growth
C5L38_RS33400	COG1674	ftsk spoiiie
C5L38_RS33545	COG3328	transposase activity
C5L38_RS33965	COG0587	DNA-directed DNA polymerase activity
C5L38_RS34050	COG1518	maintenance of DNA repeat elements
C5L38_RS34065	COG1857	crispr-associated protein
C5L38_RS34280	COG0531	amino acid
C5L38_RS34355	COG1192	Involved in chromosome partitioning
C5L38_RS34405	COG0135	phosphoribosylanthranilate isomerase activity
C5L38_RS34465	COG4942	peptidase
C5L38_RS34560	COG1556	Lactate utilization protein
C5L38_RS34580	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C5L38_RS34635	COG1309	transcriptional regulator
C5L38_RS34670	COG1309	transcriptional regulator
C5L38_RS34675	COG1902	pentaerythritol trinitrate reductase activity
C5L38_RS34675	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5L38_RS34680	COG1012	belongs to the aldehyde dehydrogenase family
C5L38_RS34690	COG1902	pentaerythritol trinitrate reductase activity
C5L38_RS34690	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5L38_RS34715	COG1012	belongs to the aldehyde dehydrogenase family
C5L38_RS34720	COG3268	Saccharopine dehydrogenase
C5L38_RS34730	COG2801	Transposase and inactivated derivatives
C5L38_RS34740	COG1309	transcriptional regulator
C5L38_RS34745	COG2409	Drug exporters of the RND superfamily
C5L38_RS34755	COG0318	PFAM AMP-dependent synthetase and ligase
C5L38_RS34765	COG0753	catalase activity
C5L38_RS34775	COG0385	Bile acid
C5L38_RS34785	COG0477	Major facilitator Superfamily
C5L38_RS34790	COG2072	flavoprotein involved in K transport
C5L38_RS34795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C5L38_RS34795	COG2226	methyltransferase
C5L38_RS34795	COG0596	Alpha beta hydrolase
C5L38_RS34830	COG1012	belongs to the aldehyde dehydrogenase family
C5L38_RS34860	COG1278	Cold shock
C5L38_RS34935	COG3547	Transposase (IS116 IS110 IS902 family)
C5L38_RS34980	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C5L38_RS34990	COG4104	PAAR repeat-containing protein
C5L38_RS34990	COG3209	COG3209 Rhs family protein
C5L38_RS35085	COG0702	epimerase
C5L38_RS35200	COG3293	Transposase
C5L38_RS35240	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C5L38_RS35295	COG3328	transposase activity
C5L38_RS35345	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C5L38_RS35415	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C5L38_RS35435	COG1556	Lactate utilization protein