locus-tag	class	description
DLM49_RS00075	COG3593	DNA synthesis involved in DNA repair
DLM49_RS00080	COG1074	ATP-dependent DNA helicase activity
DLM49_RS00140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DLM49_RS00245	COG2226	methyltransferase
DLM49_RS00255	COG3896	Chloramphenicol phosphotransferase-like protein
DLM49_RS00275	COG0154	amidase activity
DLM49_RS00285	COG3153	acetyltransferase
DLM49_RS00285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DLM49_RS00320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DLM49_RS00325	COG1940	carbohydrate kinase activity
DLM49_RS00330	COG1105	Belongs to the carbohydrate kinase PfkB family
DLM49_RS00340	COG1486	melibiose metabolic process
DLM49_RS00345	COG0395	ABC-type sugar transport system, permease component
DLM49_RS00365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DLM49_RS00375	COG1012	belongs to the aldehyde dehydrogenase family
DLM49_RS00445	COG1522	sequence-specific DNA binding
DLM49_RS00465	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS00485	COG3842	ATPase activity
DLM49_RS00495	COG1176	ABC-type spermidine putrescine transport system, permease component I
DLM49_RS00510	COG3246	L-lysine catabolic process to acetate
DLM49_RS00525	COG1454	alcohol dehydrogenase
DLM49_RS00545	COG3483	tryptophan 2,3-dioxygenase activity
DLM49_RS00550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DLM49_RS00555	COG1113	amino acid transport
DLM49_RS00580	COG1946	Acyl-CoA thioesterase
DLM49_RS00595	COG0251	oxidation-reduction process
DLM49_RS00620	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
DLM49_RS00635	COG4221	oxidoreductase activity
DLM49_RS00650	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS00655	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS00660	COG1309	transcriptional regulator
DLM49_RS00665	COG4221	oxidoreductase activity
DLM49_RS00680	COG3708	Transcriptional regulator
DLM49_RS00680	COG2207	Transcriptional regulator
DLM49_RS00695	COG0584	glycerophosphoryl diester phosphodiesterase
DLM49_RS00715	COG4977	sequence-specific DNA binding
DLM49_RS00730	COG0515	serine threonine protein kinase
DLM49_RS00745	COG0745	RESPONSE REGULATOR receiver
DLM49_RS00750	COG2205	protein histidine kinase activity
DLM49_RS00755	COG1686	Belongs to the peptidase S11 family
DLM49_RS00770	COG1136	(ABC) transporter
DLM49_RS00780	COG0577	efflux transmembrane transporter activity
DLM49_RS00785	COG1136	(ABC) transporter
DLM49_RS00790	COG0577	efflux transmembrane transporter activity
DLM49_RS00795	COG0745	RESPONSE REGULATOR receiver
DLM49_RS00800	COG2205	protein histidine kinase activity
DLM49_RS00805	COG0583	DNA-binding transcription factor activity
DLM49_RS00810	COG2080	2 iron, 2 sulfur cluster binding
DLM49_RS00815	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DLM49_RS00820	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DLM49_RS00830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DLM49_RS00875	COG0477	Major facilitator Superfamily
DLM49_RS00925	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DLM49_RS00930	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DLM49_RS00970	COG4585	Histidine kinase
DLM49_RS00990	COG0596	Alpha beta hydrolase
DLM49_RS01005	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DLM49_RS01020	COG1733	regulation of RNA biosynthetic process
DLM49_RS01055	COG0395	ABC-type sugar transport system, permease component
DLM49_RS01075	COG1819	glycosyl
DLM49_RS01105	COG0640	Transcriptional regulator
DLM49_RS01110	COG0346	lactoylglutathione lyase activity
DLM49_RS01160	COG2188	Transcriptional regulator
DLM49_RS01170	COG3537	Alpha-1,2-mannosidase
DLM49_RS01185	COG2326	polyphosphate kinase activity
DLM49_RS01190	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS01205	COG0513	Belongs to the DEAD box helicase family
DLM49_RS01225	COG0714	Associated with various cellular activities
DLM49_RS01240	COG0395	ABC-type sugar transport system, permease component
DLM49_RS01245	COG1609	Transcriptional regulator
DLM49_RS01270	COG1120	ATPase activity
DLM49_RS01290	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DLM49_RS01295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DLM49_RS01305	COG3290	protein histidine kinase activity
DLM49_RS01320	COG0367	asparagine synthase
DLM49_RS01325	COG2308	Evidence 4 Homologs of previously reported genes of
DLM49_RS01325	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DLM49_RS01340	COG0326	Molecular chaperone. Has ATPase activity
DLM49_RS01375	COG0667	Aldo Keto reductase
DLM49_RS01395	COG0559	Belongs to the binding-protein-dependent transport system permease family
DLM49_RS01410	COG2508	Transcriptional regulator
DLM49_RS01445	COG0243	molybdopterin cofactor binding
DLM49_RS01495	COG1017	nitric oxide dioxygenase activity
DLM49_RS01495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DLM49_RS01565	COG0656	L-ascorbic acid biosynthetic process
DLM49_RS01575	COG0673	inositol 2-dehydrogenase activity
DLM49_RS01670	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DLM49_RS01690	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS01695	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS01710	COG1132	(ABC) transporter
DLM49_RS01730	COG1760	l-serine dehydratase
DLM49_RS01735	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DLM49_RS01760	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DLM49_RS01780	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DLM49_RS01795	COG4176	ABC-type proline glycine betaine transport system permease component
DLM49_RS01800	COG4175	Glycine betaine
DLM49_RS01800	COG0517	IMP dehydrogenase activity
DLM49_RS01805	COG1012	belongs to the aldehyde dehydrogenase family
DLM49_RS01815	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DLM49_RS01825	COG2146	nitrite reductase [NAD(P)H] activity
DLM49_RS01840	COG0045	succinate-CoA ligase (ADP-forming) activity
DLM49_RS01840	COG1042	CoA-binding domain protein
DLM49_RS01840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DLM49_RS01845	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS01855	COG0583	DNA-binding transcription factor activity
DLM49_RS01865	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DLM49_RS01880	COG1175	transmembrane transport
DLM49_RS01885	COG0395	ABC-type sugar transport system, permease component
DLM49_RS01920	COG0517	IMP dehydrogenase activity
DLM49_RS01925	COG2208	phosphoserine phosphatase activity
DLM49_RS01925	COG2770	Histidine kinase
DLM49_RS01950	COG2274	protein secretion by the type I secretion system
DLM49_RS01970	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DLM49_RS01975	COG1879	ABC-type sugar transport system periplasmic component
DLM49_RS01980	COG1172	Belongs to the binding-protein-dependent transport system permease family
DLM49_RS01985	COG1129	ABC transporter
DLM49_RS01995	COG0698	ribose 5-phosphate isomerase
DLM49_RS02000	COG1070	Carbohydrate kinase
DLM49_RS02005	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DLM49_RS02010	COG1349	DNA-binding transcription factor activity
DLM49_RS02030	COG0248	Ppx GppA phosphatase
DLM49_RS02045	COG2890	protein-(glutamine-N5) methyltransferase activity
DLM49_RS02090	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DLM49_RS02110	COG0667	Aldo Keto reductase
DLM49_RS02135	COG0435	Glutathione S-transferase
DLM49_RS02170	COG2319	Wd-40 repeat
DLM49_RS02185	COG1796	DNA polymerase
DLM49_RS02185	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DLM49_RS02225	COG2706	6-phosphogluconolactonase activity
DLM49_RS02235	COG1309	transcriptional regulator
DLM49_RS02245	COG1595	DNA-templated transcription, initiation
DLM49_RS02260	COG1609	Transcriptional regulator
DLM49_RS02285	COG1172	Belongs to the binding-protein-dependent transport system permease family
DLM49_RS02290	COG1129	ABC transporter
DLM49_RS02295	COG4952	isomerase
DLM49_RS02300	COG3347	Dehydrogenase
DLM49_RS02300	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS02305	COG1070	Carbohydrate kinase
DLM49_RS02310	COG0247	lactate metabolic process
DLM49_RS02315	COG1139	Iron-sulfur cluster binding protein
DLM49_RS02320	COG1556	Lactate utilization protein
DLM49_RS02375	COG0242	peptide deformylase activity
DLM49_RS02385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DLM49_RS02395	COG1609	Transcriptional regulator
DLM49_RS02415	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DLM49_RS02420	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DLM49_RS02425	COG2080	2 iron, 2 sulfur cluster binding
DLM49_RS02430	COG1309	transcriptional regulator
DLM49_RS02435	COG0583	DNA-binding transcription factor activity
DLM49_RS02445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DLM49_RS02475	COG1335	isochorismatase
DLM49_RS02505	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DLM49_RS02510	COG0121	glutamine amidotransferase
DLM49_RS02515	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
DLM49_RS02520	COG2182	Extracellular solute-binding protein
DLM49_RS02525	COG3360	Dodecin
DLM49_RS02600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DLM49_RS02605	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
DLM49_RS02610	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DLM49_RS02615	COG1053	succinate dehydrogenase
DLM49_RS02625	COG0583	DNA-binding transcription factor activity
DLM49_RS02665	COG0726	polysaccharide deacetylase
DLM49_RS02685	COG2843	Capsule synthesis protein
DLM49_RS02705	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DLM49_RS02765	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DLM49_RS02770	COG0297	glycogen (starch) synthase activity
DLM49_RS02790	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DLM49_RS02825	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DLM49_RS02840	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS02855	COG2205	protein histidine kinase activity
DLM49_RS02860	COG0745	RESPONSE REGULATOR receiver
DLM49_RS02870	COG1309	transcriptional regulator
DLM49_RS02885	COG2226	methyltransferase
DLM49_RS02890	COG1657	PFAM Prenyltransferase squalene oxidase
DLM49_RS02900	COG0142	geranyltranstransferase activity
DLM49_RS02915	COG3424	synthase
DLM49_RS02920	COG0300	oxidoreductase activity
DLM49_RS02935	COG0500	methyltransferase
DLM49_RS02955	COG1132	(ABC) transporter
DLM49_RS02960	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DLM49_RS02975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DLM49_RS02980	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DLM49_RS02985	COG1120	ATPase activity
DLM49_RS02990	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DLM49_RS02995	COG3486	L-lysine 6-monooxygenase (NADPH) activity
DLM49_RS03000	COG1132	(ABC) transporter
DLM49_RS03005	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DLM49_RS03005	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DLM49_RS03025	COG1472	Belongs to the glycosyl hydrolase 3 family
DLM49_RS03035	COG1175	transmembrane transport
DLM49_RS03040	COG1653	transport
DLM49_RS03095	COG4585	Histidine kinase
DLM49_RS03100	COG2197	response regulator
DLM49_RS03110	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DLM49_RS03110	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DLM49_RS03115	COG1132	(ABC) transporter
DLM49_RS03125	COG1024	Enoyl-CoA hydratase
DLM49_RS03130	COG0668	transmembrane transport
DLM49_RS03135	COG2838	Isocitrate dehydrogenase
DLM49_RS03165	COG2197	response regulator
DLM49_RS03200	COG0673	inositol 2-dehydrogenase activity
DLM49_RS03210	COG1609	Transcriptional regulator
DLM49_RS03220	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS03225	COG0673	inositol 2-dehydrogenase activity
DLM49_RS03230	COG0673	inositol 2-dehydrogenase activity
DLM49_RS03235	COG0673	inositol 2-dehydrogenase activity
DLM49_RS03240	COG1312	Catalyzes the dehydration of D-mannonate
DLM49_RS03260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DLM49_RS03270	COG3718	enzyme involved in inositol metabolism
DLM49_RS03275	COG3962	Belongs to the TPP enzyme family
DLM49_RS03280	COG2188	Transcriptional regulator
DLM49_RS03295	COG0494	nUDIX hydrolase
DLM49_RS03330	COG0183	Belongs to the thiolase family
DLM49_RS03380	COG2197	response regulator
DLM49_RS03385	COG4585	Histidine kinase
DLM49_RS03395	COG3959	Transketolase, thiamine diphosphate binding domain
DLM49_RS03400	COG3958	Transketolase
DLM49_RS03410	COG0583	DNA-binding transcription factor activity
DLM49_RS03415	COG0156	8-amino-7-oxononanoate synthase activity
DLM49_RS03420	COG1063	alcohol dehydrogenase
DLM49_RS03450	COG0443	Heat shock 70 kDa protein
DLM49_RS03455	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DLM49_RS03460	COG0301	tRNA thio-modification
DLM49_RS03465	COG1796	DNA polymerase
DLM49_RS03465	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DLM49_RS03475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DLM49_RS03495	COG2175	clavaminate synthase activity
DLM49_RS03505	COG2755	lipolytic protein G-D-S-L family
DLM49_RS03510	COG0739	heme binding
DLM49_RS03515	COG2365	Tyrosine phosphatase family
DLM49_RS03535	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DLM49_RS03540	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DLM49_RS03555	COG1657	PFAM Prenyltransferase squalene oxidase
DLM49_RS03565	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DLM49_RS03575	COG1562	ergosterol biosynthetic process
DLM49_RS03580	COG1134	teichoic acid transport
DLM49_RS03625	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DLM49_RS03640	COG1024	Enoyl-CoA hydratase
DLM49_RS03650	COG4977	sequence-specific DNA binding
DLM49_RS03675	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DLM49_RS03680	COG2936	dipeptidyl-peptidase activity
DLM49_RS03695	COG1250	3-hydroxyacyl-CoA dehydrogenase
DLM49_RS03695	COG1024	Enoyl-CoA hydratase
DLM49_RS03700	COG0183	Belongs to the thiolase family
DLM49_RS03705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DLM49_RS03710	COG3268	Saccharopine dehydrogenase
DLM49_RS03725	COG1515	deoxyribonuclease V activity
DLM49_RS03750	COG0488	(ABC) transporter
DLM49_RS03755	COG1834	amidinotransferase
DLM49_RS03800	COG1793	dna ligase
DLM49_RS03810	COG1470	cell adhesion involved in biofilm formation
DLM49_RS03830	COG3485	protocatechuate 3,4-dioxygenase
DLM49_RS03835	COG3485	protocatechuate 3,4-dioxygenase
DLM49_RS03840	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DLM49_RS03845	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DLM49_RS03850	COG1672	PFAM Archaeal ATPase
DLM49_RS03850	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DLM49_RS03875	COG4552	Acetyltransferase involved in intracellular survival and related
DLM49_RS03880	COG1595	DNA-templated transcription, initiation
DLM49_RS03910	COG2188	Transcriptional regulator
DLM49_RS03935	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DLM49_RS03940	COG0745	RESPONSE REGULATOR receiver
DLM49_RS03990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DLM49_RS03995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DLM49_RS04010	COG0366	Alpha amylase catalytic
DLM49_RS04015	COG0395	ABC-type sugar transport system, permease component
DLM49_RS04020	COG1175	transmembrane transport
DLM49_RS04060	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DLM49_RS04070	COG1486	melibiose metabolic process
DLM49_RS04085	COG4585	Histidine kinase
DLM49_RS04090	COG2197	response regulator
DLM49_RS04095	COG2409	Drug exporters of the RND superfamily
DLM49_RS04105	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DLM49_RS04120	COG0166	Belongs to the GPI family
DLM49_RS04125	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DLM49_RS04130	COG0406	alpha-ribazole phosphatase activity
DLM49_RS04135	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DLM49_RS04140	COG3467	pyridoxamine 5'-phosphate
DLM49_RS04150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DLM49_RS04170	COG0297	glycogen (starch) synthase activity
DLM49_RS04205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DLM49_RS04215	COG1012	belongs to the aldehyde dehydrogenase family
DLM49_RS04255	COG1201	RNA secondary structure unwinding
DLM49_RS04355	COG0657	acetylesterase activity
DLM49_RS04370	COG0300	oxidoreductase activity
DLM49_RS04390	COG0789	Transcriptional regulator
DLM49_RS04420	COG4245	von Willebrand factor, type A
DLM49_RS04490	COG3552	Protein containing von Willebrand factor type A (VWA) domain
DLM49_RS04495	COG0714	Associated with various cellular activities
DLM49_RS04520	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS04530	COG2723	6-phospho-beta-galactosidase activity
DLM49_RS04535	COG0395	ABC-type sugar transport system, permease component
DLM49_RS04540	COG1175	transmembrane transport
DLM49_RS04545	COG2182	Extracellular solute-binding protein
DLM49_RS04555	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DLM49_RS04635	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DLM49_RS04655	COG0673	inositol 2-dehydrogenase activity
DLM49_RS04660	COG1879	ABC-type sugar transport system periplasmic component
DLM49_RS04665	COG1172	Belongs to the binding-protein-dependent transport system permease family
DLM49_RS04670	COG1129	ABC transporter
DLM49_RS04675	COG1940	carbohydrate kinase activity
DLM49_RS04695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DLM49_RS04705	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DLM49_RS04735	COG0656	L-ascorbic acid biosynthetic process
DLM49_RS04745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DLM49_RS04750	COG5297	Belongs to the glycosyl hydrolase family 6
DLM49_RS04755	COG4733	cellulase activity
DLM49_RS04755	COG5297	Belongs to the glycosyl hydrolase family 6
DLM49_RS04760	COG3340	Belongs to the peptidase S51 family
DLM49_RS04770	COG2154	pterin-4-alpha-carbinolamine dehydratase
DLM49_RS04790	COG0443	Heat shock 70 kDa protein
DLM49_RS04865	COG0517	IMP dehydrogenase activity
DLM49_RS04870	COG0693	protein deglycase activity
DLM49_RS04885	COG0488	(ABC) transporter
DLM49_RS04890	COG2226	methyltransferase
DLM49_RS04920	COG3547	Transposase (IS116 IS110 IS902 family)
DLM49_RS04960	COG1793	dna ligase
DLM49_RS04960	COG3285	dna ligase
DLM49_RS04975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DLM49_RS05000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DLM49_RS05005	COG1619	proteins homologs of microcin C7 resistance protein MccF
DLM49_RS05015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DLM49_RS05020	COG2362	D-Aminopeptidase
DLM49_RS05025	COG2226	methyltransferase
DLM49_RS05030	COG2172	sigma factor antagonist activity
DLM49_RS05030	COG1366	Belongs to the anti-sigma-factor antagonist family
DLM49_RS05030	COG2208	phosphoserine phosphatase activity
DLM49_RS05070	COG0596	Alpha beta hydrolase
DLM49_RS05085	COG1250	3-hydroxyacyl-CoA dehydrogenase
DLM49_RS05095	COG0604	alcohol dehydrogenase
DLM49_RS05100	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DLM49_RS05100	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DLM49_RS05105	COG2301	Belongs to the HpcH HpaI aldolase family
DLM49_RS05115	COG1960	acyl-CoA dehydrogenase activity
DLM49_RS05120	COG0688	phosphatidylethanolamine metabolic process
DLM49_RS05130	COG1929	Belongs to the glycerate kinase type-1 family
DLM49_RS05150	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DLM49_RS05200	COG0745	RESPONSE REGULATOR receiver
DLM49_RS05205	COG2205	protein histidine kinase activity
DLM49_RS05210	COG2986	histidine ammonia-lyase
DLM49_RS05215	COG0492	ferredoxin-NADP+ reductase activity
DLM49_RS05230	COG0475	glutathione-regulated potassium exporter activity
DLM49_RS05240	COG0318	PFAM AMP-dependent synthetase and ligase
DLM49_RS05245	COG0431	NADPH-dependent FMN reductase
DLM49_RS05265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DLM49_RS05275	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DLM49_RS05285	COG0483	inositol monophosphate 1-phosphatase activity
DLM49_RS05300	COG2813	Specifically methylates the guanine in position
DLM49_RS05305	COG0604	alcohol dehydrogenase
DLM49_RS05355	COG1953	Uracil, thiamine, allantoin
DLM49_RS05365	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DLM49_RS05380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DLM49_RS05410	COG0405	Gamma-glutamyltransferase
DLM49_RS05430	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DLM49_RS05435	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DLM49_RS05495	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DLM49_RS05510	COG1122	ATPase activity
DLM49_RS05515	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DLM49_RS05520	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DLM49_RS05530	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DLM49_RS05560	COG1181	Belongs to the D-alanine--D-alanine ligase family
DLM49_RS05570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DLM49_RS05575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DLM49_RS05580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DLM49_RS05585	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DLM49_RS05635	COG2814	Major facilitator Superfamily
DLM49_RS05645	COG0071	Belongs to the small heat shock protein (HSP20) family
DLM49_RS05665	COG0542	response to heat
DLM49_RS05680	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DLM49_RS05685	COG0443	Heat shock 70 kDa protein
DLM49_RS05695	COG3835	regulator
DLM49_RS05710	COG1024	Enoyl-CoA hydratase
DLM49_RS05735	COG2080	2 iron, 2 sulfur cluster binding
DLM49_RS05760	COG4221	oxidoreductase activity
DLM49_RS05780	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DLM49_RS05790	COG1918	ferrous iron import across plasma membrane
DLM49_RS05790	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DLM49_RS05795	COG1045	serine acetyltransferase
DLM49_RS05835	COG1609	Transcriptional regulator
DLM49_RS05845	COG1175	transmembrane transport
DLM49_RS05880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DLM49_RS05890	COG1940	carbohydrate kinase activity
DLM49_RS05895	COG2188	Transcriptional regulator
DLM49_RS05910	COG2197	response regulator
DLM49_RS05940	COG4266	Belongs to the allantoicase family
DLM49_RS05945	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DLM49_RS05950	COG1414	Transcriptional regulator
DLM49_RS05960	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DLM49_RS05965	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DLM49_RS05980	COG0745	RESPONSE REGULATOR receiver
DLM49_RS05985	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DLM49_RS06010	COG4221	oxidoreductase activity
DLM49_RS06020	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS06025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DLM49_RS06030	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DLM49_RS06050	COG0527	aspartate kinase activity
DLM49_RS06065	COG2132	Multicopper oxidase
DLM49_RS06075	COG2197	response regulator
DLM49_RS06080	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DLM49_RS06100	COG2409	Drug exporters of the RND superfamily
DLM49_RS06105	COG4585	Histidine kinase
DLM49_RS06125	COG3425	synthase
DLM49_RS06155	COG0142	geranyltranstransferase activity
DLM49_RS06195	COG1733	regulation of RNA biosynthetic process
DLM49_RS06200	COG0436	Aminotransferase
DLM49_RS06220	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS06255	COG2233	PERMEase
DLM49_RS06270	COG2351	hydroxyisourate hydrolase activity
DLM49_RS06330	COG3622	Belongs to the hyi family
DLM49_RS06335	COG2084	Dehydrogenase
DLM49_RS06345	COG3960	tartronate-semialdehyde synthase activity
DLM49_RS06360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DLM49_RS06365	COG2197	response regulator
DLM49_RS06405	COG0859	PFAM glycosyl transferase family 9
DLM49_RS06435	COG2252	PERMEase
DLM49_RS06440	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DLM49_RS06455	COG3835	regulator
DLM49_RS06495	COG0028	Belongs to the TPP enzyme family
DLM49_RS06510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DLM49_RS06520	COG1162	GTPase activity
DLM49_RS06525	COG5297	Belongs to the glycosyl hydrolase family 6
DLM49_RS06535	COG0277	FAD linked oxidase domain protein
DLM49_RS06540	COG1940	carbohydrate kinase activity
DLM49_RS06550	COG1175	transmembrane transport
DLM49_RS06555	COG0395	ABC-type sugar transport system, permease component
DLM49_RS06585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DLM49_RS06595	COG2040	homocysteine
DLM49_RS06615	COG2197	response regulator
DLM49_RS06630	COG1136	(ABC) transporter
DLM49_RS06635	COG0702	epimerase
DLM49_RS06645	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS06675	COG2318	DinB family
DLM49_RS06690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DLM49_RS06700	COG0583	DNA-binding transcription factor activity
DLM49_RS06705	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS06710	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS06725	COG1917	Cupin 2, conserved barrel domain protein
DLM49_RS06725	COG4977	sequence-specific DNA binding
DLM49_RS06740	COG1960	acyl-CoA dehydrogenase activity
DLM49_RS06770	COG0175	sulfate reduction
DLM49_RS06775	COG0529	Catalyzes the synthesis of activated sulfate
DLM49_RS06795	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DLM49_RS06795	COG1116	anion transmembrane transporter activity
DLM49_RS06800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DLM49_RS06810	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DLM49_RS06895	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DLM49_RS06950	COG1732	Glycine betaine
DLM49_RS06955	COG1174	glycine betaine transport
DLM49_RS06960	COG1174	glycine betaine transport
DLM49_RS06990	COG0745	RESPONSE REGULATOR receiver
DLM49_RS06995	COG2205	protein histidine kinase activity
DLM49_RS07010	COG5002	protein histidine kinase activity
DLM49_RS07015	COG0745	RESPONSE REGULATOR receiver
DLM49_RS07065	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DLM49_RS07070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DLM49_RS07090	COG3321	synthase
DLM49_RS07090	COG0604	alcohol dehydrogenase
DLM49_RS07095	COG1733	regulation of RNA biosynthetic process
DLM49_RS07100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DLM49_RS07105	COG1917	Cupin 2, conserved barrel domain protein
DLM49_RS07105	COG4977	sequence-specific DNA binding
DLM49_RS07130	COG0723	plastoquinol--plastocyanin reductase activity
DLM49_RS07130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DLM49_RS07170	COG3220	belongs to the UPF0276 family
DLM49_RS07180	COG0596	Alpha beta hydrolase
DLM49_RS07185	COG3253	May function as heme-dependent peroxidase
DLM49_RS07190	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DLM49_RS07200	COG0446	pyridine nucleotide-disulphide oxidoreductase
DLM49_RS07220	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DLM49_RS07235	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DLM49_RS07250	COG0183	Belongs to the thiolase family
DLM49_RS07255	COG1024	Enoyl-CoA hydratase
DLM49_RS07255	COG1250	3-hydroxyacyl-CoA dehydrogenase
DLM49_RS07270	COG0531	amino acid
DLM49_RS07275	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DLM49_RS07280	COG4214	carbohydrate transport
DLM49_RS07290	COG4213	ABC transporter substrate-binding protein
DLM49_RS07295	COG1940	carbohydrate kinase activity
DLM49_RS07300	COG0395	ABC-type sugar transport system, permease component
DLM49_RS07305	COG1175	transmembrane transport
DLM49_RS07310	COG1653	transport
DLM49_RS07340	COG0395	ABC-type sugar transport system, permease component
DLM49_RS07345	COG4209	transmembrane transport
DLM49_RS07350	COG3458	cephalosporin-C deacetylase activity
DLM49_RS07355	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DLM49_RS07365	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DLM49_RS07380	COG4124	Belongs to the glycosyl hydrolase 26 family
DLM49_RS07390	COG1482	cell wall glycoprotein biosynthetic process
DLM49_RS07410	COG3833	ABC-type maltose transport systems, permease component
DLM49_RS07415	COG1175	transmembrane transport
DLM49_RS07420	COG2182	Extracellular solute-binding protein
DLM49_RS07425	COG1940	carbohydrate kinase activity
DLM49_RS07435	COG1609	Transcriptional regulator
DLM49_RS07445	COG1175	transmembrane transport
DLM49_RS07450	COG0395	ABC-type sugar transport system, permease component
DLM49_RS07455	COG1621	beta-fructofuranosidase activity
DLM49_RS07465	COG1595	DNA-templated transcription, initiation
DLM49_RS07485	COG0384	phenazine biosynthesis protein PhzF
DLM49_RS07495	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DLM49_RS07495	COG1672	PFAM Archaeal ATPase
DLM49_RS07550	COG2319	Wd-40 repeat
DLM49_RS07550	COG4249	Peptidase C14 caspase catalytic subunit p20
DLM49_RS07600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DLM49_RS07605	COG0601	transmembrane transport
DLM49_RS07615	COG0310	cobalt ion transport
DLM49_RS07625	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DLM49_RS07630	COG1122	ATPase activity
DLM49_RS07640	COG0431	NADPH-dependent FMN reductase
DLM49_RS07650	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DLM49_RS07655	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DLM49_RS07660	COG2828	Protein conserved in bacteria
DLM49_RS07670	COG0235	Class ii aldolase
DLM49_RS07680	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DLM49_RS07685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DLM49_RS07690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DLM49_RS07700	COG2814	Major facilitator Superfamily
DLM49_RS07705	COG2814	Major facilitator Superfamily
DLM49_RS07710	COG2255	four-way junction helicase activity
DLM49_RS07740	COG2267	carboxylic ester hydrolase activity
DLM49_RS07775	COG1024	Enoyl-CoA hydratase
DLM49_RS07785	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DLM49_RS07790	COG2235	arginine
DLM49_RS07795	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DLM49_RS07830	COG1799	cell septum assembly
DLM49_RS07840	COG1472	Belongs to the glycosyl hydrolase 3 family
DLM49_RS07845	COG0395	ABC-type sugar transport system, permease component
DLM49_RS07850	COG1175	transmembrane transport
DLM49_RS07855	COG2182	Extracellular solute-binding protein
DLM49_RS07860	COG2188	Transcriptional regulator
DLM49_RS07865	COG0667	Aldo Keto reductase
DLM49_RS07875	COG1442	glycosyl transferase family 8
DLM49_RS07875	COG1216	Glycosyl transferase, family 2
DLM49_RS07885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DLM49_RS07890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DLM49_RS07895	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DLM49_RS07900	COG1216	Glycosyl transferase, family 2
DLM49_RS07915	COG1472	Belongs to the glycosyl hydrolase 3 family
DLM49_RS07950	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DLM49_RS07955	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DLM49_RS07975	COG0367	asparagine synthase
DLM49_RS08015	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DLM49_RS08030	COG4310	Domain of unknown function (DUF2172)
DLM49_RS08040	COG1216	Glycosyl transferase, family 2
DLM49_RS08055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DLM49_RS08070	COG0110	maltose O-acetyltransferase activity
DLM49_RS08095	COG0501	Belongs to the peptidase M48B family
DLM49_RS08110	COG3693	PFAM glycoside hydrolase, family 10
DLM49_RS08125	COG0154	amidase activity
DLM49_RS08180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DLM49_RS08190	COG1846	Transcriptional regulator
DLM49_RS08190	COG1940	carbohydrate kinase activity
DLM49_RS08195	COG0028	Belongs to the TPP enzyme family
DLM49_RS08200	COG0726	polysaccharide deacetylase
DLM49_RS08205	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DLM49_RS08210	COG2080	2 iron, 2 sulfur cluster binding
DLM49_RS08215	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DLM49_RS08240	COG0701	Predicted permease
DLM49_RS08250	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DLM49_RS08255	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DLM49_RS08260	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DLM49_RS08265	COG0254	rRNA binding
DLM49_RS08275	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DLM49_RS08315	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DLM49_RS08320	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DLM49_RS08325	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DLM49_RS08330	COG0254	rRNA binding
DLM49_RS08345	COG1169	isochorismate synthase
DLM49_RS08350	COG1132	(ABC) transporter
DLM49_RS08355	COG1132	(ABC) transporter
DLM49_RS08355	COG2375	cellular response to nickel ion
DLM49_RS08365	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DLM49_RS08370	COG2124	cytochrome p450
DLM49_RS08385	COG2226	methyltransferase
DLM49_RS08385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DLM49_RS08385	COG3433	isochorismatase activity
DLM49_RS08390	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DLM49_RS08390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DLM49_RS08395	COG1021	2,3-dihydroxybenzoate-AMP ligase
DLM49_RS08405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DLM49_RS08410	COG0601	transmembrane transport
DLM49_RS08480	COG1609	Transcriptional regulator
DLM49_RS08485	COG4166	transmembrane transport
DLM49_RS08490	COG0601	transmembrane transport
DLM49_RS08495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DLM49_RS08500	COG0444	Belongs to the ABC transporter superfamily
DLM49_RS08505	COG4608	Belongs to the ABC transporter superfamily
DLM49_RS08520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DLM49_RS08525	COG0531	amino acid
DLM49_RS08530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DLM49_RS08535	COG0569	domain protein
DLM49_RS08560	COG4591	ABC-type transport system involved in lipoprotein release permease component
DLM49_RS08560	COG1136	(ABC) transporter
DLM49_RS08570	COG0756	dUTP diphosphatase activity
DLM49_RS08600	COG2205	protein histidine kinase activity
DLM49_RS08605	COG0745	RESPONSE REGULATOR receiver
DLM49_RS08615	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DLM49_RS08655	COG5002	protein histidine kinase activity
DLM49_RS08660	COG0745	RESPONSE REGULATOR receiver
DLM49_RS08675	COG0577	efflux transmembrane transporter activity
DLM49_RS08675	COG1136	(ABC) transporter
DLM49_RS08680	COG1136	(ABC) transporter
DLM49_RS08680	COG0577	efflux transmembrane transporter activity
DLM49_RS08685	COG1435	thymidine kinase activity
DLM49_RS08710	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DLM49_RS08715	COG1802	Transcriptional regulator
DLM49_RS08730	COG0612	Peptidase, M16
DLM49_RS08740	COG0523	cobalamin synthesis protein
DLM49_RS08755	COG0372	Belongs to the citrate synthase family
DLM49_RS08770	COG3290	protein histidine kinase activity
DLM49_RS08775	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DLM49_RS08785	COG0187	DNA topoisomerase II activity
DLM49_RS08800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DLM49_RS08805	COG2186	Transcriptional regulator
DLM49_RS08845	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DLM49_RS08880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DLM49_RS08885	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DLM49_RS08890	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DLM49_RS08925	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DLM49_RS08935	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DLM49_RS08940	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DLM49_RS08950	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DLM49_RS08970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DLM49_RS08985	COG2358	TRAP transporter, solute receptor (TAXI family
DLM49_RS08990	COG2205	protein histidine kinase activity
DLM49_RS08995	COG0745	RESPONSE REGULATOR receiver
DLM49_RS09000	COG1126	abc transporter atp-binding protein
DLM49_RS09005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DLM49_RS09010	COG0765	amino acid transport
DLM49_RS09015	COG0765	amino acid transport
DLM49_RS09030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DLM49_RS09045	COG0628	permease
DLM49_RS09075	COG1201	RNA secondary structure unwinding
DLM49_RS09085	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DLM49_RS09095	COG0783	Belongs to the Dps family
DLM49_RS09100	COG1396	sequence-specific DNA binding
DLM49_RS09105	COG1058	Belongs to the CinA family
DLM49_RS09105	COG1546	Belongs to the CinA family
DLM49_RS09115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DLM49_RS09125	COG1674	ftsk spoiiie
DLM49_RS09135	COG2205	protein histidine kinase activity
DLM49_RS09135	COG3850	Histidine kinase
DLM49_RS09135	COG4999	Histidine kinase
DLM49_RS09135	COG3437	response regulator, receiver
DLM49_RS09145	COG2770	Histidine kinase
DLM49_RS09145	COG2208	phosphoserine phosphatase activity
DLM49_RS09180	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DLM49_RS09185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DLM49_RS09190	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DLM49_RS09205	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DLM49_RS09210	COG0612	Peptidase, M16
DLM49_RS09215	COG1185	polyribonucleotide nucleotidyltransferase activity
DLM49_RS09220	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DLM49_RS09235	COG1674	ftsk spoiiie
DLM49_RS09290	COG1404	Belongs to the peptidase S8 family
DLM49_RS09305	COG1404	Belongs to the peptidase S8 family
DLM49_RS09325	COG0455	bacterial-type flagellum organization
DLM49_RS09330	COG0747	negative chemotaxis
DLM49_RS09335	COG0601	transmembrane transport
DLM49_RS09370	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DLM49_RS09375	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DLM49_RS09385	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DLM49_RS09400	COG0779	Required for maturation of 30S ribosomal subunits
DLM49_RS09430	COG1595	DNA-templated transcription, initiation
DLM49_RS09445	COG0442	prolyl-tRNA aminoacylation
DLM49_RS09460	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DLM49_RS09465	COG0750	zinc metalloprotease
DLM49_RS09470	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DLM49_RS09480	COG1012	belongs to the aldehyde dehydrogenase family
DLM49_RS09490	COG2508	Transcriptional regulator
DLM49_RS09520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DLM49_RS09525	COG1177	transmembrane transport
DLM49_RS09535	COG3842	ATPase activity
DLM49_RS09565	COG0584	glycerophosphoryl diester phosphodiesterase
DLM49_RS09570	COG0596	Alpha beta hydrolase
DLM49_RS09575	COG3629	intracellular signal transduction
DLM49_RS09575	COG3903	Transcriptional regulator
DLM49_RS09580	COG1012	belongs to the aldehyde dehydrogenase family
DLM49_RS09590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DLM49_RS09625	COG3842	ATPase activity
DLM49_RS09630	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DLM49_RS09640	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DLM49_RS09645	COG0575	Belongs to the CDS family
DLM49_RS09650	COG0233	cytoplasmic translational termination
DLM49_RS09655	COG0528	UMP kinase activity
DLM49_RS09660	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DLM49_RS09665	COG0052	Belongs to the universal ribosomal protein uS2 family
DLM49_RS09680	COG1191	sigma factor activity
DLM49_RS09695	COG0792	nuclease activity
DLM49_RS09715	COG0681	Belongs to the peptidase S26 family
DLM49_RS09725	COG0681	Belongs to the peptidase S26 family
DLM49_RS09730	COG0335	large ribosomal subunit rRNA binding
DLM49_RS09735	COG0336	Belongs to the RNA methyltransferase TrmD family
DLM49_RS09740	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DLM49_RS09745	COG1837	Belongs to the UPF0109 family
DLM49_RS09750	COG0228	four-way junction DNA binding
DLM49_RS09770	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DLM49_RS09800	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
DLM49_RS09810	COG0477	Major facilitator Superfamily
DLM49_RS09835	COG1254	Belongs to the acylphosphatase family
DLM49_RS09845	COG1733	regulation of RNA biosynthetic process
DLM49_RS09850	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DLM49_RS09855	COG0571	ribonuclease III activity
DLM49_RS09860	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DLM49_RS09875	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DLM49_RS09880	COG0742	ribosomal rna small subunit methyltransferase
DLM49_RS09890	COG1461	Dihydroxyacetone kinase
DLM49_RS09895	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DLM49_RS09900	COG0351	phosphomethylpyrimidine kinase
DLM49_RS09915	COG1181	Belongs to the D-alanine--D-alanine ligase family
DLM49_RS09920	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DLM49_RS09930	COG1920	GTP binding
DLM49_RS09940	COG0776	regulation of translation
DLM49_RS09950	COG0066	3-isopropylmalate dehydratase activity
DLM49_RS09955	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DLM49_RS09960	COG1414	Transcriptional regulator
DLM49_RS09970	COG0789	Transcriptional regulator
DLM49_RS10005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DLM49_RS10010	COG0179	Fumarylacetoacetate (FAA) hydrolase
DLM49_RS10020	COG5002	protein histidine kinase activity
DLM49_RS10025	COG2018	Roadblock/LC7 domain
DLM49_RS10045	COG2018	Roadblock/LC7 domain
DLM49_RS10065	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DLM49_RS10070	COG0300	oxidoreductase activity
DLM49_RS10075	COG1032	radical SAM domain protein
DLM49_RS10080	COG2353	YceI-like domain
DLM49_RS10090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DLM49_RS10105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DLM49_RS10110	COG0473	3-isopropylmalate dehydrogenase activity
DLM49_RS10120	COG1012	belongs to the aldehyde dehydrogenase family
DLM49_RS10125	COG0506	proline dehydrogenase activity
DLM49_RS10130	COG3835	regulator
DLM49_RS10140	COG0477	Major facilitator Superfamily
DLM49_RS10145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DLM49_RS10150	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DLM49_RS10155	COG0440	acetolactate synthase activity
DLM49_RS10180	COG0667	Aldo Keto reductase
DLM49_RS10185	COG2133	pyrroloquinoline quinone binding
DLM49_RS10195	COG1672	PFAM Archaeal ATPase
DLM49_RS10195	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DLM49_RS10215	COG2409	Drug exporters of the RND superfamily
DLM49_RS10225	COG2226	methyltransferase
DLM49_RS10230	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DLM49_RS10240	COG0154	amidase activity
DLM49_RS10245	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DLM49_RS10255	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DLM49_RS10265	COG4221	oxidoreductase activity
DLM49_RS10270	COG1611	Belongs to the LOG family
DLM49_RS10290	COG0482	sulfurtransferase activity
DLM49_RS10325	COG2860	membrane
DLM49_RS10330	COG4608	Belongs to the ABC transporter superfamily
DLM49_RS10335	COG0444	Belongs to the ABC transporter superfamily
DLM49_RS10340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DLM49_RS10345	COG0601	transmembrane transport
DLM49_RS10370	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DLM49_RS10375	COG0509	glycine decarboxylation via glycine cleavage system
DLM49_RS10380	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DLM49_RS10385	COG1760	l-serine dehydratase
DLM49_RS10390	COG3757	hydrolase, family 25
DLM49_RS10390	COG3409	Peptidoglycan-binding domain 1 protein
DLM49_RS10435	COG1132	(ABC) transporter
DLM49_RS10440	COG1132	(ABC) transporter
DLM49_RS10445	COG1132	(ABC) transporter
DLM49_RS10450	COG1132	(ABC) transporter
DLM49_RS10460	COG2205	protein histidine kinase activity
DLM49_RS10465	COG0745	RESPONSE REGULATOR receiver
DLM49_RS10475	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DLM49_RS10475	COG2755	lipolytic protein G-D-S-L family
DLM49_RS10495	COG0583	DNA-binding transcription factor activity
DLM49_RS10500	COG0058	SHG alpha-glucan phosphorylase activity
DLM49_RS10510	COG0366	Alpha amylase catalytic
DLM49_RS10520	COG3281	Trehalose synthase
DLM49_RS10525	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DLM49_RS10535	COG3118	belongs to the thioredoxin family
DLM49_RS10545	COG1301	dicarboxylic acid transport
DLM49_RS10550	COG3290	protein histidine kinase activity
DLM49_RS10565	COG0604	alcohol dehydrogenase
DLM49_RS10585	COG0205	6-phosphofructokinase activity
DLM49_RS10590	COG0280	phosphate acetyltransferase
DLM49_RS10590	COG0857	belongs to the CobB CobQ family
DLM49_RS10595	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DLM49_RS10640	COG0583	DNA-binding transcription factor activity
DLM49_RS10650	COG2855	membrane
DLM49_RS10655	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DLM49_RS10655	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DLM49_RS10705	COG4106	trans-aconitate 2-methyltransferase activity
DLM49_RS10730	COG0745	RESPONSE REGULATOR receiver
DLM49_RS10770	COG0183	Belongs to the thiolase family
DLM49_RS10825	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
DLM49_RS10840	COG1250	3-hydroxyacyl-CoA dehydrogenase
DLM49_RS10855	COG4585	Histidine kinase
DLM49_RS10860	COG2197	response regulator
DLM49_RS10880	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DLM49_RS10885	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DLM49_RS10890	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DLM49_RS10895	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DLM49_RS10900	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DLM49_RS10905	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DLM49_RS10910	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DLM49_RS10925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DLM49_RS10930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DLM49_RS10935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DLM49_RS10945	COG2890	protein-(glutamine-N5) methyltransferase activity
DLM49_RS10950	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DLM49_RS10955	COG0254	rRNA binding
DLM49_RS10970	COG0083	homoserine kinase activity
DLM49_RS10975	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DLM49_RS10980	COG0460	homoserine dehydrogenase
DLM49_RS10985	COG0019	diaminopimelate decarboxylase activity
DLM49_RS10990	COG0018	arginyl-trna synthetase
DLM49_RS10995	COG0745	RESPONSE REGULATOR receiver
DLM49_RS11050	COG4106	trans-aconitate 2-methyltransferase activity
DLM49_RS11055	COG1653	transport
DLM49_RS11060	COG4209	transmembrane transport
DLM49_RS11065	COG0395	ABC-type sugar transport system, permease component
DLM49_RS11080	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DLM49_RS11085	COG0142	geranyltranstransferase activity
DLM49_RS11105	COG2175	clavaminate synthase activity
DLM49_RS11115	COG4585	Histidine kinase
DLM49_RS11120	COG2197	response regulator
DLM49_RS11130	COG1595	DNA-templated transcription, initiation
DLM49_RS11140	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DLM49_RS11145	COG1793	dna ligase
DLM49_RS11145	COG3285	dna ligase
DLM49_RS11245	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DLM49_RS11255	COG0745	RESPONSE REGULATOR receiver
DLM49_RS11260	COG2205	protein histidine kinase activity
DLM49_RS11270	COG0508	dehydrogenase complex catalyzes the overall conversion of
DLM49_RS11270	COG0567	Dehydrogenase, E1 component
DLM49_RS11300	COG0604	alcohol dehydrogenase
DLM49_RS11305	COG0281	malic enzyme
DLM49_RS11315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DLM49_RS11320	COG0765	amino acid transport
DLM49_RS11325	COG1126	abc transporter atp-binding protein
DLM49_RS11330	COG4106	trans-aconitate 2-methyltransferase activity
DLM49_RS11390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DLM49_RS11400	COG0456	acetyltransferase
DLM49_RS11405	COG0142	geranyltranstransferase activity
DLM49_RS11410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DLM49_RS11440	COG1191	sigma factor activity
DLM49_RS11450	COG1597	lipid kinase activity
DLM49_RS11465	COG0363	glucosamine-6-phosphate deaminase activity
DLM49_RS11470	COG2188	Transcriptional regulator
DLM49_RS11510	COG2124	cytochrome p450
DLM49_RS11520	COG0242	peptide deformylase activity
DLM49_RS11535	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DLM49_RS11535	COG2199	diguanylate cyclase activity
DLM49_RS11540	COG5662	AntiSigma factor
DLM49_RS11545	COG1595	DNA-templated transcription, initiation
DLM49_RS11555	COG2135	peptidase activity
DLM49_RS11570	COG0300	oxidoreductase activity
DLM49_RS11590	COG3547	Transposase (IS116 IS110 IS902 family)
DLM49_RS11600	COG0515	serine threonine protein kinase
DLM49_RS11600	COG2815	serine threonine protein kinase
DLM49_RS11645	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DLM49_RS11650	COG1162	GTPase activity
DLM49_RS11655	COG2076	Multidrug Resistance protein
DLM49_RS11665	COG0483	inositol monophosphate 1-phosphatase activity
DLM49_RS11675	COG0753	catalase activity
DLM49_RS11700	COG1615	UPF0182 protein
DLM49_RS11710	COG3480	Lon protease (S16) C-terminal proteolytic domain
DLM49_RS11760	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DLM49_RS11800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DLM49_RS11805	COG0210	DNA helicase
DLM49_RS11830	COG0596	Alpha beta hydrolase
DLM49_RS11905	COG1432	Conserved Protein
DLM49_RS11915	COG2095	MarC family integral membrane protein
DLM49_RS11920	COG0613	PHP domain protein
DLM49_RS11935	COG0598	Magnesium transport protein CorA
DLM49_RS11970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DLM49_RS11975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DLM49_RS11990	COG1595	DNA-templated transcription, initiation
DLM49_RS12005	COG1024	Enoyl-CoA hydratase
DLM49_RS12010	COG0519	Catalyzes the synthesis of GMP from XMP
DLM49_RS12020	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DLM49_RS12030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DLM49_RS12075	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DLM49_RS12135	COG1695	Transcriptional regulator
DLM49_RS12155	COG0154	amidase activity
DLM49_RS12170	COG4608	Belongs to the ABC transporter superfamily
DLM49_RS12180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DLM49_RS12185	COG0601	transmembrane transport
DLM49_RS12195	COG4608	Belongs to the ABC transporter superfamily
DLM49_RS12200	COG0444	Belongs to the ABC transporter superfamily
DLM49_RS12210	COG4166	transmembrane transport
DLM49_RS12215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DLM49_RS12220	COG1217	gtp-binding protein TYPA
DLM49_RS12240	COG1053	succinate dehydrogenase
DLM49_RS12295	COG0583	DNA-binding transcription factor activity
DLM49_RS12310	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DLM49_RS12335	COG1136	(ABC) transporter
DLM49_RS12335	COG0577	efflux transmembrane transporter activity
DLM49_RS12340	COG1136	(ABC) transporter
DLM49_RS12340	COG0577	efflux transmembrane transporter activity
DLM49_RS12350	COG2205	protein histidine kinase activity
DLM49_RS12355	COG0745	RESPONSE REGULATOR receiver
DLM49_RS12360	COG1309	transcriptional regulator
DLM49_RS12375	COG0012	GTP binding
DLM49_RS12390	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DLM49_RS12395	COG1570	exodeoxyribonuclease VII activity
DLM49_RS12400	COG1722	exodeoxyribonuclease VII activity
DLM49_RS12430	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DLM49_RS12430	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DLM49_RS12435	COG1051	belongs to the nudix hydrolase family
DLM49_RS12445	COG0114	fumarate hydratase activity
DLM49_RS12460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DLM49_RS12480	COG1136	(ABC) transporter
DLM49_RS12495	COG0450	alkyl hydroperoxide reductase
DLM49_RS12500	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DLM49_RS12515	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DLM49_RS12520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DLM49_RS12555	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS12610	COG2197	response regulator
DLM49_RS12615	COG3920	Histidine kinase
DLM49_RS12645	COG2894	cell division
DLM49_RS12680	COG2610	gluconate transmembrane transporter activity
DLM49_RS12685	COG0251	oxidation-reduction process
DLM49_RS12690	COG1414	Transcriptional regulator
DLM49_RS12705	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DLM49_RS12715	COG0436	Aminotransferase
DLM49_RS12820	COG1960	acyl-CoA dehydrogenase activity
DLM49_RS12830	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DLM49_RS12840	COG0477	Major facilitator Superfamily
DLM49_RS12845	COG1309	transcriptional regulator
DLM49_RS12875	COG1331	Highly conserved protein containing a thioredoxin domain
DLM49_RS12905	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DLM49_RS12915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DLM49_RS12930	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DLM49_RS12935	COG2255	four-way junction helicase activity
DLM49_RS12960	COG1090	epimerase
DLM49_RS12965	COG1064	alcohol dehydrogenase
DLM49_RS12995	COG2986	histidine ammonia-lyase
DLM49_RS13005	COG1024	Enoyl-CoA hydratase
DLM49_RS13015	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DLM49_RS13025	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DLM49_RS13040	COG0424	maF-like protein
DLM49_RS13050	COG4770	biotin carboxylase activity
DLM49_RS13075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DLM49_RS13090	COG1012	belongs to the aldehyde dehydrogenase family
DLM49_RS13095	COG1012	belongs to the aldehyde dehydrogenase family
DLM49_RS13110	COG1595	DNA-templated transcription, initiation
DLM49_RS13115	COG0745	RESPONSE REGULATOR receiver
DLM49_RS13120	COG2205	protein histidine kinase activity
DLM49_RS13145	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DLM49_RS13155	COG0583	DNA-binding transcription factor activity
DLM49_RS13160	COG2814	Major facilitator Superfamily
DLM49_RS13185	COG1079	Belongs to the binding-protein-dependent transport system permease family
DLM49_RS13195	COG3845	ABC transporter
DLM49_RS13200	COG1744	ABC transporter substrate-binding protein PnrA-like
DLM49_RS13205	COG1744	ABC transporter substrate-binding protein PnrA-like
DLM49_RS13210	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DLM49_RS13210	COG1473	amidohydrolase
DLM49_RS13220	COG2089	acid synthase
DLM49_RS13235	COG1216	Glycosyl transferase, family 2
DLM49_RS13245	COG1216	Glycosyl transferase, family 2
DLM49_RS13275	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DLM49_RS13275	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DLM49_RS13340	COG2009	succinate dehydrogenase
DLM49_RS13350	COG1053	succinate dehydrogenase
DLM49_RS13370	COG1309	transcriptional regulator
DLM49_RS13375	COG2409	Drug exporters of the RND superfamily
DLM49_RS13380	COG0745	RESPONSE REGULATOR receiver
DLM49_RS13385	COG2205	protein histidine kinase activity
DLM49_RS13390	COG1408	metallophosphoesterase
DLM49_RS13400	COG1686	Belongs to the peptidase S11 family
DLM49_RS13405	COG1295	ribonuclease BN
DLM49_RS13420	COG0671	phosphoesterase, PA-phosphatase related
DLM49_RS13440	COG0180	Tryptophanyl-tRNA synthetase
DLM49_RS13460	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DLM49_RS13470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DLM49_RS13475	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DLM49_RS13485	COG4176	ABC-type proline glycine betaine transport system permease component
DLM49_RS13490	COG0517	IMP dehydrogenase activity
DLM49_RS13490	COG4175	Glycine betaine
DLM49_RS13500	COG1012	belongs to the aldehyde dehydrogenase family
DLM49_RS13505	COG0039	L-malate dehydrogenase activity
DLM49_RS13520	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DLM49_RS13540	COG0515	serine threonine protein kinase
DLM49_RS13545	COG3409	Peptidoglycan-binding domain 1 protein
DLM49_RS13555	COG0138	bifunctional purine biosynthesis protein purh
DLM49_RS13585	COG0045	succinate-CoA ligase (ADP-forming) activity
DLM49_RS13605	COG3552	Protein containing von Willebrand factor type A (VWA) domain
DLM49_RS13615	COG0714	Associated with various cellular activities
DLM49_RS13630	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DLM49_RS13630	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DLM49_RS13640	COG0739	heme binding
DLM49_RS13665	COG2197	response regulator
DLM49_RS13705	COG0519	Catalyzes the synthesis of GMP from XMP
DLM49_RS13705	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DLM49_RS13730	COG1012	belongs to the aldehyde dehydrogenase family
DLM49_RS13735	COG0515	serine threonine protein kinase
DLM49_RS13740	COG0515	serine threonine protein kinase
DLM49_RS13745	COG0515	serine threonine protein kinase
DLM49_RS13775	COG0516	GMP reductase activity
DLM49_RS13785	COG1595	DNA-templated transcription, initiation
DLM49_RS13800	COG0583	DNA-binding transcription factor activity
DLM49_RS13880	COG0657	acetylesterase activity
DLM49_RS13890	COG0459	protein refolding
DLM49_RS13895	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DLM49_RS13900	COG0726	polysaccharide deacetylase
DLM49_RS13905	COG0726	polysaccharide deacetylase
DLM49_RS13915	COG4941	Belongs to the sigma-70 factor family
DLM49_RS13940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DLM49_RS13960	COG0802	atpase or kinase
DLM49_RS13970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DLM49_RS13980	COG1191	sigma factor activity
DLM49_RS13985	COG0736	holo-[acyl-carrier-protein] synthase activity
DLM49_RS13995	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DLM49_RS14005	COG1072	(Pantothenic acid kinase))
DLM49_RS14015	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DLM49_RS14020	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DLM49_RS14055	COG2843	Capsule synthesis protein
DLM49_RS14065	COG0101	tRNA pseudouridine synthase activity
DLM49_RS14070	COG0203	ribosomal protein L17
DLM49_RS14075	COG0202	RNA polymerase activity
DLM49_RS14080	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DLM49_RS14085	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DLM49_RS14090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DLM49_RS14095	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DLM49_RS14105	COG0563	adenylate kinase activity
DLM49_RS14110	COG0201	protein transport
DLM49_RS14115	COG0200	Binds to the 23S rRNA
DLM49_RS14120	COG1841	ribosomal large subunit assembly
DLM49_RS14125	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DLM49_RS14130	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DLM49_RS14135	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DLM49_RS14140	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DLM49_RS14150	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DLM49_RS14155	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DLM49_RS14160	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DLM49_RS14165	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DLM49_RS14170	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DLM49_RS14175	COG0255	Belongs to the universal ribosomal protein uL29 family
DLM49_RS14180	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DLM49_RS14185	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DLM49_RS14190	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DLM49_RS14195	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DLM49_RS14200	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DLM49_RS14205	COG0089	rRNA binding
DLM49_RS14210	COG0088	Forms part of the polypeptide exit tunnel
DLM49_RS14215	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DLM49_RS14220	COG0051	transcription antitermination factor activity, RNA binding
DLM49_RS14235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DLM49_RS14290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DLM49_RS14295	COG0667	Aldo Keto reductase
DLM49_RS14315	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DLM49_RS14320	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DLM49_RS14325	COG0049	tRNA binding
DLM49_RS14330	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DLM49_RS14370	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DLM49_RS14375	COG0085	RNA polymerase activity
DLM49_RS14385	COG0222	ribosome binding
DLM49_RS14390	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DLM49_RS14400	COG0081	regulation of translation
DLM49_RS14405	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DLM49_RS14410	COG0250	Participates in transcription elongation, termination and antitermination
DLM49_RS14425	COG0436	Aminotransferase
DLM49_RS14430	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DLM49_RS14435	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DLM49_RS14445	COG2030	dehydratase
DLM49_RS14450	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DLM49_RS14465	COG0402	S-adenosylhomocysteine deaminase activity
DLM49_RS14470	COG0702	epimerase
DLM49_RS14485	COG1666	GTP binding
DLM49_RS14490	COG2261	transglycosylase associated protein
DLM49_RS14500	COG3304	Inner membrane component domain
DLM49_RS14505	COG0501	Belongs to the peptidase M48B family
DLM49_RS14510	COG1007	ATP synthesis coupled electron transport
DLM49_RS14525	COG0713	ATP synthesis coupled electron transport
DLM49_RS14530	COG0839	Belongs to the complex I subunit 6 family
DLM49_RS14535	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DLM49_RS14540	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DLM49_RS14545	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DLM49_RS14550	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DLM49_RS14555	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DLM49_RS14575	COG0674	pyruvate-flavodoxin oxidoreductase activity
DLM49_RS14575	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DLM49_RS14580	COG1013	pyruvate-flavodoxin oxidoreductase activity
DLM49_RS14585	COG1733	regulation of RNA biosynthetic process
DLM49_RS14590	COG0702	epimerase
DLM49_RS14620	COG0655	NAD(P)H dehydrogenase (quinone) activity
DLM49_RS14630	COG1131	(ABC) transporter
DLM49_RS14640	COG0142	geranyltranstransferase activity
DLM49_RS14705	COG0514	ATP-dependent DNA helicase (RecQ)
DLM49_RS14710	COG1007	ATP synthesis coupled electron transport
DLM49_RS14720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DLM49_RS14725	COG0713	ATP synthesis coupled electron transport
DLM49_RS14730	COG0839	Belongs to the complex I subunit 6 family
DLM49_RS14735	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DLM49_RS14740	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DLM49_RS14745	COG1034	ATP synthesis coupled electron transport
DLM49_RS14750	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DLM49_RS14760	COG0649	NAD binding
DLM49_RS14765	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DLM49_RS14770	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DLM49_RS14805	COG2226	methyltransferase
DLM49_RS14815	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DLM49_RS14835	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DLM49_RS14840	COG1278	Cold shock
DLM49_RS14845	COG2226	methyltransferase
DLM49_RS14855	COG0183	Belongs to the thiolase family
DLM49_RS14860	COG3547	Transposase (IS116 IS110 IS902 family)
DLM49_RS14880	COG1309	transcriptional regulator
DLM49_RS14895	COG1301	dicarboxylic acid transport
DLM49_RS14910	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DLM49_RS14920	COG0163	prenyltransferase activity
DLM49_RS14940	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DLM49_RS14965	COG1309	transcriptional regulator
DLM49_RS14980	COG0492	ferredoxin-NADP+ reductase activity
DLM49_RS14985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DLM49_RS14995	COG0798	PFAM Bile acid sodium symporter
DLM49_RS15000	COG2072	flavoprotein involved in K transport
DLM49_RS15010	COG2072	flavoprotein involved in K transport
DLM49_RS15015	COG0640	Transcriptional regulator
DLM49_RS15020	COG0640	Transcriptional regulator
DLM49_RS15120	COG0582	viral genome integration into host DNA
DLM49_RS15135	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DLM49_RS15140	COG0406	alpha-ribazole phosphatase activity
DLM49_RS15150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DLM49_RS15155	COG0785	Cytochrome C biogenesis protein
DLM49_RS15160	COG1333	cytochrome c biogenesis protein
DLM49_RS15165	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DLM49_RS15190	COG0702	epimerase
DLM49_RS15195	COG3631	Ketosteroid isomerase-related protein
DLM49_RS15225	COG0640	Transcriptional regulator
DLM49_RS15255	COG0659	secondary active sulfate transmembrane transporter activity
DLM49_RS15265	COG2340	Cysteine-rich secretory protein family
DLM49_RS15300	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DLM49_RS15335	COG0693	protein deglycase activity
DLM49_RS15345	COG1366	Belongs to the anti-sigma-factor antagonist family
DLM49_RS15365	COG2770	Histidine kinase
DLM49_RS15365	COG2208	phosphoserine phosphatase activity
DLM49_RS15370	COG0489	protein tyrosine kinase activity
DLM49_RS15375	COG0366	Alpha amylase catalytic
DLM49_RS15405	COG4221	oxidoreductase activity
DLM49_RS15415	COG2814	Major facilitator Superfamily
DLM49_RS15445	COG0297	glycogen (starch) synthase activity
DLM49_RS15450	COG2205	protein histidine kinase activity
DLM49_RS15455	COG0745	RESPONSE REGULATOR receiver
DLM49_RS15465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DLM49_RS15475	COG1846	Transcriptional regulator
DLM49_RS15480	COG1742	UPF0060 membrane protein
DLM49_RS15490	COG1690	Belongs to the RtcB family
DLM49_RS15510	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DLM49_RS15515	COG0018	arginyl-trna synthetase
DLM49_RS15560	COG0113	porphobilinogen synthase activity
DLM49_RS15570	COG1280	lysine exporter protein (LysE YggA)
DLM49_RS15580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DLM49_RS15625	COG1648	precorrin-2 dehydrogenase activity
DLM49_RS15625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DLM49_RS15630	COG0181	hydroxymethylbilane synthase activity
DLM49_RS15635	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DLM49_RS15640	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DLM49_RS15695	COG0123	including yeast histone deacetylase and acetoin utilization protein
DLM49_RS15700	COG0738	Major facilitator superfamily
DLM49_RS15705	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DLM49_RS15730	COG0180	Tryptophanyl-tRNA synthetase
DLM49_RS15745	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DLM49_RS15755	COG1129	ABC transporter
DLM49_RS15755	COG0842	Transport permease protein
DLM49_RS15775	COG4991	sh3 domain protein
DLM49_RS15780	COG0515	serine threonine protein kinase
DLM49_RS15780	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DLM49_RS15785	COG0129	dihydroxy-acid dehydratase activity
DLM49_RS15790	COG1309	transcriptional regulator
DLM49_RS15795	COG1082	Xylose isomerase domain protein TIM barrel
DLM49_RS15800	COG0248	Ppx GppA phosphatase
DLM49_RS15820	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DLM49_RS15835	COG1194	a g-specific adenine glycosylase
DLM49_RS15840	COG1595	DNA-templated transcription, initiation
DLM49_RS15850	COG0745	RESPONSE REGULATOR receiver
DLM49_RS15855	COG2205	protein histidine kinase activity
DLM49_RS15860	COG0346	lactoylglutathione lyase activity
DLM49_RS15910	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DLM49_RS15930	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DLM49_RS15940	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DLM49_RS15945	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DLM49_RS15960	COG1660	Displays ATPase and GTPase activities
DLM49_RS15965	COG2197	response regulator
DLM49_RS15980	COG0649	NAD binding
DLM49_RS16000	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DLM49_RS16000	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DLM49_RS16015	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DLM49_RS16030	COG0302	gtp cyclohydrolase
DLM49_RS16045	COG0037	tRNA processing
DLM49_RS16055	COG2027	D-alanyl-D-alanine carboxypeptidase
DLM49_RS16060	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DLM49_RS16070	COG0586	Pfam SNARE associated Golgi protein
DLM49_RS16075	COG0789	Transcriptional regulator
DLM49_RS16085	COG0076	glutamate decarboxylase activity
DLM49_RS16110	COG1012	belongs to the aldehyde dehydrogenase family
DLM49_RS16145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DLM49_RS16145	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DLM49_RS16150	COG3629	intracellular signal transduction
DLM49_RS16150	COG3903	Transcriptional regulator
DLM49_RS16170	COG1960	acyl-CoA dehydrogenase activity
DLM49_RS16175	COG3321	synthase
DLM49_RS16180	COG3629	intracellular signal transduction
DLM49_RS16200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DLM49_RS16205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DLM49_RS16210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DLM49_RS16215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DLM49_RS16220	COG0156	8-amino-7-oxononanoate synthase activity
DLM49_RS16225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DLM49_RS16235	COG1091	dTDP-4-dehydrorhamnose reductase activity
DLM49_RS16245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DLM49_RS16255	COG4638	Rieske (2fe-2S)
DLM49_RS16270	COG1136	(ABC) transporter
DLM49_RS16270	COG0577	efflux transmembrane transporter activity
DLM49_RS16275	COG1309	transcriptional regulator
DLM49_RS16305	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DLM49_RS16310	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DLM49_RS16310	COG1754	DNA topoisomerase type I activity
DLM49_RS16320	COG2264	protein methyltransferase activity
DLM49_RS16330	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DLM49_RS16335	COG2172	sigma factor antagonist activity
DLM49_RS16340	COG1366	Belongs to the anti-sigma-factor antagonist family
DLM49_RS16410	COG0659	secondary active sulfate transmembrane transporter activity
DLM49_RS16415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DLM49_RS16420	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DLM49_RS16430	COG0596	Alpha beta hydrolase
DLM49_RS16465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DLM49_RS16490	COG0003	Pfam Anion-transporting ATPase
DLM49_RS16545	COG1408	metallophosphoesterase
DLM49_RS16580	COG0297	glycogen (starch) synthase activity
DLM49_RS16590	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DLM49_RS16605	COG2192	nodulation
DLM49_RS16610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DLM49_RS16620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DLM49_RS16625	COG0017	Asparaginyl-tRNA synthetase
DLM49_RS16635	COG0270	DNA (cytosine-5-)-methyltransferase activity
DLM49_RS16650	COG1674	ftsk spoiiie
DLM49_RS16695	COG1404	Belongs to the peptidase S8 family
DLM49_RS16700	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DLM49_RS16715	COG0475	glutathione-regulated potassium exporter activity
DLM49_RS16720	COG3263	regulation of cellular component size
DLM49_RS16735	COG3321	synthase
DLM49_RS16735	COG0604	alcohol dehydrogenase
DLM49_RS16735	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS16765	COG0701	Predicted permease
DLM49_RS16780	COG0477	Major facilitator Superfamily
DLM49_RS16800	COG1595	DNA-templated transcription, initiation
DLM49_RS16820	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DLM49_RS16825	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DLM49_RS16840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DLM49_RS16845	COG1802	Transcriptional regulator
DLM49_RS16855	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DLM49_RS16875	COG1131	(ABC) transporter
DLM49_RS16880	COG3559	Exporter of polyketide antibiotics
DLM49_RS16895	COG2197	response regulator
DLM49_RS16900	COG4585	Histidine kinase
DLM49_RS16905	COG2197	response regulator
DLM49_RS16910	COG4585	Histidine kinase
DLM49_RS16935	COG3844	kynureninase activity
DLM49_RS16955	COG0191	fructose-bisphosphate aldolase activity
DLM49_RS16960	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DLM49_RS16975	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DLM49_RS17005	COG0542	response to heat
DLM49_RS17040	COG4213	ABC transporter substrate-binding protein
DLM49_RS17045	COG0789	Transcriptional regulator
DLM49_RS17050	COG0484	heat shock protein binding
DLM49_RS17055	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DLM49_RS17060	COG0443	Heat shock 70 kDa protein
DLM49_RS17065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DLM49_RS17070	COG2181	nitrate reductase activity
DLM49_RS17070	COG0247	lactate metabolic process
DLM49_RS17080	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DLM49_RS17085	COG0717	Belongs to the dCTP deaminase family
DLM49_RS17260	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DLM49_RS17285	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS17300	COG1309	transcriptional regulator
DLM49_RS17305	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS17315	COG3835	regulator
DLM49_RS17330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DLM49_RS17330	COG0723	plastoquinol--plastocyanin reductase activity
DLM49_RS17340	COG0667	Aldo Keto reductase
DLM49_RS17345	COG1012	belongs to the aldehyde dehydrogenase family
DLM49_RS17350	COG3608	succinylglutamate desuccinylase aspartoacylase
DLM49_RS17355	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DLM49_RS17360	COG1177	transmembrane transport
DLM49_RS17370	COG3842	ATPase activity
DLM49_RS17385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DLM49_RS17415	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DLM49_RS17435	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DLM49_RS17435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DLM49_RS17440	COG1461	Dihydroxyacetone kinase
DLM49_RS17445	COG2376	Dihydroxyacetone kinase
DLM49_RS17450	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DLM49_RS17460	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DLM49_RS17475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DLM49_RS17495	COG0586	Pfam SNARE associated Golgi protein
DLM49_RS17500	COG4585	Histidine kinase
DLM49_RS17510	COG1366	Belongs to the anti-sigma-factor antagonist family
DLM49_RS17510	COG2172	sigma factor antagonist activity
DLM49_RS17510	COG2208	phosphoserine phosphatase activity
DLM49_RS17520	COG1595	DNA-templated transcription, initiation
DLM49_RS17530	COG4213	ABC transporter substrate-binding protein
DLM49_RS17545	COG2367	Beta-lactamase
DLM49_RS17555	COG0583	DNA-binding transcription factor activity
DLM49_RS17565	COG1278	Cold shock
DLM49_RS17595	COG2409	Drug exporters of the RND superfamily
DLM49_RS17610	COG0366	Alpha amylase catalytic
DLM49_RS17620	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DLM49_RS17640	COG1396	sequence-specific DNA binding
DLM49_RS17690	COG0583	DNA-binding transcription factor activity
DLM49_RS17705	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DLM49_RS17755	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DLM49_RS17765	COG1741	Belongs to the pirin family
DLM49_RS17775	COG1960	acyl-CoA dehydrogenase activity
DLM49_RS17785	COG1362	aminopeptidase activity
DLM49_RS17835	COG0508	dehydrogenase complex catalyzes the overall conversion of
DLM49_RS17840	COG0022	dehydrogenase e1 component
DLM49_RS17850	COG0515	serine threonine protein kinase
DLM49_RS17855	COG0515	serine threonine protein kinase
DLM49_RS17870	COG0604	alcohol dehydrogenase
DLM49_RS17890	COG0303	'Molybdopterin
DLM49_RS17915	COG1522	sequence-specific DNA binding
DLM49_RS17920	COG1309	transcriptional regulator
DLM49_RS17925	COG1250	3-hydroxyacyl-CoA dehydrogenase
DLM49_RS17950	COG3396	Phenylacetate-CoA oxygenase
DLM49_RS17955	COG3460	Phenylacetate-CoA oxygenase
DLM49_RS17960	COG3396	Phenylacetate-CoA oxygenase
DLM49_RS17965	COG2151	metal-sulfur cluster biosynthetic enzyme
DLM49_RS17970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DLM49_RS18010	COG1716	ATPase activity
DLM49_RS18015	COG1716	ATPase activity
DLM49_RS18030	COG0768	penicillin binding
DLM49_RS18040	COG0515	serine threonine protein kinase
DLM49_RS18045	COG3764	Sortase (surface protein transpeptidase)
DLM49_RS18050	COG3764	Sortase (surface protein transpeptidase)
DLM49_RS18075	COG0705	Rhomboid family
DLM49_RS18100	COG0515	serine threonine protein kinase
DLM49_RS18135	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DLM49_RS18140	COG0187	DNA topoisomerase II activity
DLM49_RS18145	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
DLM49_RS18150	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DLM49_RS18155	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DLM49_RS18160	COG0592	DNA-directed DNA polymerase activity
DLM49_RS18170	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DLM49_RS18180	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DLM49_RS18185	COG0594	ribonuclease P activity
DLM49_RS18190	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DLM49_RS18195	COG0706	membrane insertase activity
DLM49_RS18205	COG0357	Ribosomal RNA small subunit methyltransferase G
DLM49_RS18210	COG1192	Involved in chromosome partitioning
DLM49_RS18225	COG3118	belongs to the thioredoxin family
DLM49_RS18230	COG0492	ferredoxin-NADP+ reductase activity
DLM49_RS18240	COG1595	DNA-templated transcription, initiation
DLM49_RS18260	COG0617	tRNA 3'-terminal CCA addition
DLM49_RS18275	COG1260	myo-inositol-1-phosphate synthase
DLM49_RS18285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DLM49_RS18310	COG0360	Binds together with S18 to 16S ribosomal RNA
DLM49_RS18315	COG0629	single-stranded DNA binding
DLM49_RS18320	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DLM49_RS18325	COG0359	binds to the 23S rRNA
DLM49_RS18335	COG0305	Participates in initiation and elongation during chromosome replication
DLM49_RS18380	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DLM49_RS18385	COG1181	Belongs to the D-alanine--D-alanine ligase family
DLM49_RS18395	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DLM49_RS18405	COG0745	RESPONSE REGULATOR receiver
DLM49_RS18410	COG2205	protein histidine kinase activity
DLM49_RS18440	COG2814	Major facilitator Superfamily
DLM49_RS18465	COG0626	cystathionine gamma-synthase activity
DLM49_RS18470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DLM49_RS18475	COG1950	PFAM Membrane protein of
DLM49_RS18480	COG0662	Cupin 2, conserved barrel domain protein
DLM49_RS18505	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DLM49_RS18525	COG1609	Transcriptional regulator
DLM49_RS18530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DLM49_RS18535	COG1271	oxidase subunit
DLM49_RS18540	COG1294	oxidase, subunit
DLM49_RS18545	COG4988	ABC transporter
DLM49_RS18555	COG0561	phosphatase activity
DLM49_RS18575	COG0305	Participates in initiation and elongation during chromosome replication
DLM49_RS18605	COG0242	peptide deformylase activity
DLM49_RS18645	COG0494	nUDIX hydrolase
DLM49_RS18675	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DLM49_RS18700	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
DLM49_RS18735	COG0561	phosphatase activity
DLM49_RS18740	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DLM49_RS18745	COG0077	Prephenate dehydratase
DLM49_RS18750	COG2837	iron assimilation
DLM49_RS18765	COG1999	signal sequence binding
DLM49_RS18785	COG0006	proline dipeptidase activity
DLM49_RS18805	COG0653	protein targeting
DLM49_RS18840	COG0784	Response regulator, receiver
DLM49_RS18845	COG0318	PFAM AMP-dependent synthetase and ligase
DLM49_RS18850	COG1595	DNA-templated transcription, initiation
DLM49_RS18870	COG1902	pentaerythritol trinitrate reductase activity
DLM49_RS18870	COG0446	pyridine nucleotide-disulphide oxidoreductase
DLM49_RS18890	COG0277	FAD linked oxidase domain protein
DLM49_RS18895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DLM49_RS18915	COG0745	RESPONSE REGULATOR receiver
DLM49_RS18920	COG0477	Major facilitator Superfamily
DLM49_RS18930	COG3467	pyridoxamine 5'-phosphate
DLM49_RS18950	COG1191	sigma factor activity
DLM49_RS18955	COG1191	sigma factor activity
DLM49_RS18990	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DLM49_RS19035	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS19045	COG0438	transferase activity, transferring glycosyl groups
DLM49_RS19050	COG0438	transferase activity, transferring glycosyl groups
DLM49_RS19080	COG0151	Belongs to the GarS family
DLM49_RS19100	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DLM49_RS19110	COG2197	response regulator
DLM49_RS19145	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DLM49_RS19150	COG0047	phosphoribosylformylglycinamidine synthase activity
DLM49_RS19155	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DLM49_RS19165	COG0741	lytic transglycosylase activity
DLM49_RS19165	COG1196	nuclear chromosome segregation
DLM49_RS19165	COG0739	heme binding
DLM49_RS19185	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DLM49_RS19195	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DLM49_RS19220	COG1643	Atp-dependent helicase
DLM49_RS19255	COG0513	Belongs to the DEAD box helicase family
DLM49_RS19280	COG3851	Histidine kinase
DLM49_RS19285	COG2197	response regulator
DLM49_RS19290	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DLM49_RS19290	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DLM49_RS19305	COG1196	nuclear chromosome segregation
DLM49_RS19305	COG0741	lytic transglycosylase activity
DLM49_RS19305	COG0739	heme binding
DLM49_RS19315	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DLM49_RS19320	COG0579	oxidoreductase
DLM49_RS19340	COG1252	NADH dehydrogenase
DLM49_RS19375	COG2197	response regulator
DLM49_RS19380	COG4585	Histidine kinase
DLM49_RS19390	COG2267	carboxylic ester hydrolase activity
DLM49_RS19445	COG1136	(ABC) transporter
DLM49_RS19450	COG0577	efflux transmembrane transporter activity
DLM49_RS19450	COG1136	(ABC) transporter
DLM49_RS19455	COG0741	lytic transglycosylase activity
DLM49_RS19455	COG0739	heme binding
DLM49_RS19455	COG1196	nuclear chromosome segregation
DLM49_RS19460	COG0671	phosphoesterase, PA-phosphatase related
DLM49_RS19465	COG0277	FAD linked oxidase domain protein
DLM49_RS19480	COG0300	oxidoreductase activity
DLM49_RS19485	COG1937	Protein conserved in bacteria
DLM49_RS19495	COG0306	phosphate transporter
DLM49_RS19500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DLM49_RS19520	COG0406	alpha-ribazole phosphatase activity
DLM49_RS19520	COG0494	nUDIX hydrolase
DLM49_RS19535	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DLM49_RS19565	COG0456	acetyltransferase
DLM49_RS19635	COG1674	ftsk spoiiie
DLM49_RS19650	COG0745	RESPONSE REGULATOR receiver
DLM49_RS19655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DLM49_RS19660	COG1609	Transcriptional regulator
DLM49_RS19665	COG0745	RESPONSE REGULATOR receiver
DLM49_RS19690	COG2897	thiosulfate sulfurtransferase activity
DLM49_RS19735	COG3485	protocatechuate 3,4-dioxygenase
DLM49_RS19745	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DLM49_RS19750	COG1490	D-aminoacyl-tRNA deacylase activity
DLM49_RS19760	COG4552	Acetyltransferase involved in intracellular survival and related
DLM49_RS19780	COG2188	Transcriptional regulator
DLM49_RS19800	COG2186	Transcriptional regulator
DLM49_RS19805	COG0156	8-amino-7-oxononanoate synthase activity
DLM49_RS19815	COG1175	transmembrane transport
DLM49_RS19820	COG0395	ABC-type sugar transport system, permease component
DLM49_RS19825	COG2318	DinB family
DLM49_RS19865	COG0438	transferase activity, transferring glycosyl groups
DLM49_RS19895	COG2226	methyltransferase
DLM49_RS19935	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DLM49_RS19940	COG0300	oxidoreductase activity
DLM49_RS19955	COG0588	phosphoglycerate mutase activity
DLM49_RS19970	COG5002	protein histidine kinase activity
DLM49_RS19990	COG1329	Transcriptional regulator
DLM49_RS20000	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DLM49_RS20005	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DLM49_RS20010	COG0215	cysteine-tRNA ligase activity
DLM49_RS20040	COG3842	ATPase activity
DLM49_RS20045	COG2378	regulation of single-species biofilm formation
DLM49_RS20085	COG0583	DNA-binding transcription factor activity
DLM49_RS20110	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DLM49_RS20130	COG1105	Belongs to the carbohydrate kinase PfkB family
DLM49_RS20145	COG2182	Extracellular solute-binding protein
DLM49_RS20170	COG0463	Glycosyl transferase, family 2
DLM49_RS20175	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DLM49_RS20185	COG1278	Cold shock
DLM49_RS20190	COG0459	protein refolding
DLM49_RS20200	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DLM49_RS20205	COG1737	Transcriptional regulator
DLM49_RS20240	COG3973	AAA domain
DLM49_RS20250	COG0667	Aldo Keto reductase
DLM49_RS20275	COG0464	growth
DLM49_RS20350	COG1061	Type III restriction enzyme res subunit
DLM49_RS20375	COG1278	Cold shock
DLM49_RS20380	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DLM49_RS20385	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DLM49_RS20395	COG2814	Major facilitator Superfamily
DLM49_RS20435	COG0739	heme binding
DLM49_RS20440	COG2267	carboxylic ester hydrolase activity
DLM49_RS20455	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DLM49_RS20455	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DLM49_RS20460	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DLM49_RS20470	COG2252	PERMEase
DLM49_RS20495	COG0667	Aldo Keto reductase
DLM49_RS20555	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DLM49_RS20590	COG0277	FAD linked oxidase domain protein
DLM49_RS20590	COG0247	lactate metabolic process
DLM49_RS20595	COG0739	heme binding
DLM49_RS20610	COG2188	Transcriptional regulator
DLM49_RS20615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DLM49_RS20630	COG5006	permease, DMT superfamily
DLM49_RS20655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DLM49_RS20670	COG0318	PFAM AMP-dependent synthetase and ligase
DLM49_RS20685	COG0259	pyridoxamine-phosphate oxidase activity
DLM49_RS20695	COG2945	thiolester hydrolase activity
DLM49_RS20695	COG0596	Alpha beta hydrolase
DLM49_RS20705	COG4821	SIS domain
DLM49_RS20790	COG2271	Major facilitator Superfamily
DLM49_RS20795	COG2072	flavoprotein involved in K transport
DLM49_RS20800	COG0259	pyridoxamine-phosphate oxidase activity
DLM49_RS20810	COG1309	transcriptional regulator
DLM49_RS20835	COG3629	intracellular signal transduction
DLM49_RS20835	COG3903	Transcriptional regulator
DLM49_RS20855	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DLM49_RS20890	COG1686	Belongs to the peptidase S11 family
DLM49_RS20915	COG0386	Belongs to the glutathione peroxidase family
DLM49_RS20970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DLM49_RS20975	COG0569	domain protein
DLM49_RS20990	COG0515	serine threonine protein kinase
DLM49_RS21005	COG2188	Transcriptional regulator
DLM49_RS21045	COG2188	Transcriptional regulator
DLM49_RS21055	COG2188	Transcriptional regulator
DLM49_RS21120	COG1309	transcriptional regulator
DLM49_RS21170	COG1846	Transcriptional regulator
DLM49_RS21175	COG3384	dioxygenase
DLM49_RS21180	COG1247	-acetyltransferase
DLM49_RS21195	COG0477	Major facilitator Superfamily
DLM49_RS21200	COG1349	DNA-binding transcription factor activity
DLM49_RS21210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DLM49_RS21210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DLM49_RS21210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DLM49_RS21225	COG3191	aminopeptidase activity
DLM49_RS21235	COG1970	mechanosensitive ion channel activity
DLM49_RS21245	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DLM49_RS21260	COG3263	regulation of cellular component size
DLM49_RS21270	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DLM49_RS21275	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DLM49_RS21285	COG0315	cyclic pyranopterin monophosphate synthase activity
DLM49_RS21290	COG0315	cyclic pyranopterin monophosphate synthase activity
DLM49_RS21290	COG0521	Mo-molybdopterin cofactor biosynthetic process
DLM49_RS21295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DLM49_RS21345	COG0454	-acetyltransferase
DLM49_RS21350	COG0708	Exodeoxyribonuclease III
DLM49_RS21360	COG2072	flavoprotein involved in K transport
DLM49_RS21365	COG2267	carboxylic ester hydrolase activity
DLM49_RS21395	COG2409	Drug exporters of the RND superfamily
DLM49_RS21400	COG0442	prolyl-tRNA aminoacylation
DLM49_RS21415	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DLM49_RS21420	COG1122	ATPase activity
DLM49_RS21430	COG0310	cobalt ion transport
DLM49_RS21475	COG0084	hydrolase, TatD family'
DLM49_RS21485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DLM49_RS21490	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DLM49_RS21500	COG0488	(ABC) transporter
DLM49_RS21540	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DLM49_RS21550	COG2197	response regulator
DLM49_RS21560	COG4106	trans-aconitate 2-methyltransferase activity
DLM49_RS21575	COG1309	transcriptional regulator
DLM49_RS21585	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DLM49_RS21595	COG0193	aminoacyl-tRNA hydrolase activity
DLM49_RS21600	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DLM49_RS21605	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DLM49_RS21610	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DLM49_RS21625	COG4585	Histidine kinase
DLM49_RS21655	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DLM49_RS21665	COG1136	(ABC) transporter
DLM49_RS21670	COG0577	efflux transmembrane transporter activity
DLM49_RS21715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DLM49_RS21725	COG2124	cytochrome p450
DLM49_RS21740	COG0148	phosphopyruvate hydratase activity
DLM49_RS21760	COG1252	NADH dehydrogenase
DLM49_RS21765	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DLM49_RS21770	COG0577	efflux transmembrane transporter activity
DLM49_RS21775	COG1136	(ABC) transporter
DLM49_RS21775	COG0577	efflux transmembrane transporter activity
DLM49_RS21815	COG0183	Belongs to the thiolase family
DLM49_RS21820	COG2755	lipolytic protein G-D-S-L family
DLM49_RS21850	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DLM49_RS21865	COG1228	amidohydrolase
DLM49_RS21870	COG1191	sigma factor activity
DLM49_RS21875	COG1366	Belongs to the anti-sigma-factor antagonist family
DLM49_RS21885	COG3104	oligopeptide transport
DLM49_RS21890	COG0745	RESPONSE REGULATOR receiver
DLM49_RS21895	COG2205	protein histidine kinase activity
DLM49_RS21910	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DLM49_RS21940	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DLM49_RS21950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DLM49_RS21960	COG1316	TRANSCRIPTIONal
DLM49_RS21995	COG1316	TRANSCRIPTIONal
DLM49_RS22000	COG1316	TRANSCRIPTIONal
DLM49_RS22005	COG1316	TRANSCRIPTIONal
DLM49_RS22030	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
DLM49_RS22030	COG0778	Nitroreductase
DLM49_RS22035	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DLM49_RS22075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DLM49_RS22085	COG2835	tetraacyldisaccharide 4'-kinase activity
DLM49_RS22095	COG1482	cell wall glycoprotein biosynthetic process
DLM49_RS22105	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DLM49_RS22150	COG0714	Associated with various cellular activities
DLM49_RS22170	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DLM49_RS22175	COG0745	RESPONSE REGULATOR receiver
DLM49_RS22180	COG5002	protein histidine kinase activity
DLM49_RS22180	COG5000	phosphorelay sensor kinase activity
DLM49_RS22185	COG0823	Involved in the tonB-independent uptake of proteins
DLM49_RS22195	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DLM49_RS22200	COG2197	response regulator
DLM49_RS22205	COG3214	Protein conserved in bacteria
DLM49_RS22215	COG0653	protein targeting
DLM49_RS22235	COG2902	Dehydrogenase
DLM49_RS22245	COG1215	transferase activity, transferring glycosyl groups
DLM49_RS22250	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DLM49_RS22255	COG1134	teichoic acid transport
DLM49_RS22275	COG1846	Transcriptional regulator
DLM49_RS22280	COG1764	response to oxidative stress
DLM49_RS22295	COG1216	Glycosyl transferase, family 2
DLM49_RS22300	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DLM49_RS22305	COG1216	Glycosyl transferase, family 2
DLM49_RS22310	COG0395	ABC-type sugar transport system, permease component
DLM49_RS22315	COG1175	transmembrane transport
DLM49_RS22335	COG0515	serine threonine protein kinase
DLM49_RS22340	COG0515	serine threonine protein kinase
DLM49_RS22345	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DLM49_RS22360	COG2884	Cell division ATP-binding protein ftsE
DLM49_RS22370	COG0793	Belongs to the peptidase S41A family
DLM49_RS22375	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DLM49_RS22410	COG2223	nitrite transmembrane transporter activity
DLM49_RS22435	COG3973	AAA domain
DLM49_RS22445	COG0776	regulation of translation
DLM49_RS22450	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DLM49_RS22455	COG1678	Uncharacterized ACR, COG1678
DLM49_RS22470	COG1175	transmembrane transport
DLM49_RS22475	COG0395	ABC-type sugar transport system, permease component
DLM49_RS22480	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DLM49_RS22485	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DLM49_RS22500	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DLM49_RS22520	COG3654	unkown
DLM49_RS22535	COG3480	Lon protease (S16) C-terminal proteolytic domain
DLM49_RS22555	COG1174	glycine betaine transport
DLM49_RS22565	COG1174	glycine betaine transport
DLM49_RS22575	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DLM49_RS22595	COG1476	TRANSCRIPTIONal
DLM49_RS22615	COG1674	ftsk spoiiie
DLM49_RS22655	COG4974	Belongs to the 'phage' integrase family
DLM49_RS22680	COG0583	DNA-binding transcription factor activity
DLM49_RS22690	COG0300	oxidoreductase activity
DLM49_RS22695	COG0745	RESPONSE REGULATOR receiver
DLM49_RS22700	COG2205	protein histidine kinase activity
DLM49_RS22705	COG2409	Drug exporters of the RND superfamily
DLM49_RS22720	COG0277	FAD linked oxidase domain protein
DLM49_RS22750	COG1335	isochorismatase
DLM49_RS22760	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DLM49_RS22770	COG1115	amino acid carrier protein
DLM49_RS22795	COG1234	tRNA 3'-trailer cleavage
DLM49_RS22800	COG1263	PTS System
DLM49_RS22805	COG1263	PTS System
DLM49_RS22810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DLM49_RS22820	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DLM49_RS22830	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DLM49_RS22860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DLM49_RS22875	COG4555	ABC transporter
DLM49_RS22900	COG2733	membrane
DLM49_RS22905	COG2814	Major facilitator Superfamily
DLM49_RS22940	COG0110	maltose O-acetyltransferase activity
DLM49_RS22945	COG3226	Transcriptional regulator
DLM49_RS22950	COG3795	YCII-related domain
DLM49_RS22955	COG4941	Belongs to the sigma-70 factor family
DLM49_RS22980	COG3619	membrane
DLM49_RS22985	COG0405	Gamma-glutamyltransferase
DLM49_RS23005	COG0436	Aminotransferase
DLM49_RS23010	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DLM49_RS23035	COG0640	Transcriptional regulator
DLM49_RS23040	COG2249	NAD(P)H dehydrogenase (quinone) activity
DLM49_RS23060	COG0596	Alpha beta hydrolase
DLM49_RS23145	COG0604	alcohol dehydrogenase
DLM49_RS23145	COG3321	synthase
DLM49_RS23165	COG0179	Fumarylacetoacetate (FAA) hydrolase
DLM49_RS23170	COG4702	Belongs to the UPF0303 family
DLM49_RS23175	COG0673	inositol 2-dehydrogenase activity
DLM49_RS23180	COG1940	carbohydrate kinase activity
DLM49_RS23185	COG0515	serine threonine protein kinase
DLM49_RS23240	COG3397	chitin binding
DLM49_RS23255	COG1126	abc transporter atp-binding protein
DLM49_RS23260	COG0765	amino acid transport
DLM49_RS23265	COG0765	amino acid transport
DLM49_RS23270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DLM49_RS23325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DLM49_RS23330	COG1132	(ABC) transporter
DLM49_RS23355	COG2197	response regulator
DLM49_RS23360	COG4585	Histidine kinase
DLM49_RS23390	COG4974	Belongs to the 'phage' integrase family
DLM49_RS23415	COG2188	Transcriptional regulator
DLM49_RS23470	COG3328	transposase activity
DLM49_RS23505	COG0406	alpha-ribazole phosphatase activity
DLM49_RS23520	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DLM49_RS23530	COG0745	RESPONSE REGULATOR receiver
DLM49_RS23540	COG3979	chitinase
DLM49_RS23550	COG0395	ABC-type sugar transport system, permease component
DLM49_RS23585	COG0166	Belongs to the GPI family
DLM49_RS23590	COG0515	serine threonine protein kinase
DLM49_RS23590	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DLM49_RS23605	COG0438	transferase activity, transferring glycosyl groups
DLM49_RS23610	COG3903	Transcriptional regulator
DLM49_RS23610	COG2197	response regulator
DLM49_RS23630	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DLM49_RS23635	COG4977	sequence-specific DNA binding
DLM49_RS23645	COG0589	response to stress
DLM49_RS23650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DLM49_RS23685	COG3486	L-lysine 6-monooxygenase (NADPH) activity
DLM49_RS23705	COG1960	acyl-CoA dehydrogenase activity
DLM49_RS23720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DLM49_RS23725	COG1309	transcriptional regulator
DLM49_RS23735	COG1946	Acyl-CoA thioesterase
DLM49_RS23765	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DLM49_RS23775	COG0028	Belongs to the TPP enzyme family
DLM49_RS23780	COG2356	endonuclease I
DLM49_RS23815	COG1733	regulation of RNA biosynthetic process
DLM49_RS23825	COG1472	Belongs to the glycosyl hydrolase 3 family
DLM49_RS23835	COG0697	spore germination
DLM49_RS23855	COG1609	Transcriptional regulator
DLM49_RS23860	COG0673	inositol 2-dehydrogenase activity
DLM49_RS23875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DLM49_RS23885	COG0596	Alpha beta hydrolase
DLM49_RS23890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DLM49_RS23900	COG1846	Transcriptional regulator
DLM49_RS23950	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DLM49_RS23975	COG2409	Drug exporters of the RND superfamily
DLM49_RS24010	COG2197	response regulator
DLM49_RS24015	COG4585	Histidine kinase
DLM49_RS24020	COG2409	Drug exporters of the RND superfamily
DLM49_RS24055	COG0492	ferredoxin-NADP+ reductase activity
DLM49_RS24070	COG0438	transferase activity, transferring glycosyl groups
DLM49_RS24080	COG0728	peptidoglycan biosynthetic process
DLM49_RS24095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DLM49_RS24185	COG0318	PFAM AMP-dependent synthetase and ligase
DLM49_RS24190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DLM49_RS24195	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DLM49_RS24195	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DLM49_RS24200	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DLM49_RS24200	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DLM49_RS24220	COG3321	synthase
DLM49_RS24220	COG0604	alcohol dehydrogenase
DLM49_RS24225	COG0604	alcohol dehydrogenase
DLM49_RS24225	COG3321	synthase
DLM49_RS24245	COG2197	response regulator
DLM49_RS24250	COG0318	PFAM AMP-dependent synthetase and ligase
DLM49_RS24270	COG0604	alcohol dehydrogenase
DLM49_RS24325	COG0629	single-stranded DNA binding
DLM49_RS24360	COG1136	(ABC) transporter
DLM49_RS24430	COG1486	melibiose metabolic process
DLM49_RS24445	COG0668	transmembrane transport
DLM49_RS24470	COG0179	Fumarylacetoacetate (FAA) hydrolase
DLM49_RS24485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DLM49_RS24530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DLM49_RS24560	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS24565	COG0583	DNA-binding transcription factor activity
DLM49_RS24570	COG2353	YceI-like domain
DLM49_RS24595	COG2337	Toxic component of a toxin-antitoxin (TA) module
DLM49_RS24640	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DLM49_RS24645	COG1113	amino acid transport
DLM49_RS24650	COG1268	BioY protein
DLM49_RS24675	COG4552	Acetyltransferase involved in intracellular survival and related
DLM49_RS24690	COG3594	Acyltransferase
DLM49_RS24710	COG0544	peptidyl-prolyl cis-trans isomerase activity
DLM49_RS24715	COG0740	serine-type endopeptidase activity
DLM49_RS24720	COG0740	serine-type endopeptidase activity
DLM49_RS24725	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DLM49_RS24740	COG0525	valine-tRNA ligase activity
DLM49_RS24750	COG0285	dihydrofolate synthase activity
DLM49_RS24760	COG0105	UTP biosynthetic process
DLM49_RS24765	COG1077	Cell shape determining protein MreB Mrl
DLM49_RS24785	COG0772	Belongs to the SEDS family
DLM49_RS24810	COG3328	transposase activity
DLM49_RS24850	COG0702	epimerase
DLM49_RS24865	COG1530	ribonuclease E activity
DLM49_RS24875	COG0371	Dehydrogenase
DLM49_RS24880	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DLM49_RS24885	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DLM49_RS24890	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DLM49_RS24905	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DLM49_RS24910	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DLM49_RS24920	COG1309	transcriptional regulator
DLM49_RS24925	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS24940	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DLM49_RS24950	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DLM49_RS24965	COG0501	Belongs to the peptidase M48B family
DLM49_RS24970	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DLM49_RS24980	COG0799	negative regulation of ribosome biogenesis
DLM49_RS24985	COG0588	phosphoglycerate mutase activity
DLM49_RS25010	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DLM49_RS25020	COG0495	leucyl-tRNA aminoacylation
DLM49_RS25030	COG1307	EDD domain protein, DegV family
DLM49_RS25040	COG1234	tRNA 3'-trailer cleavage
DLM49_RS25065	COG0268	Binds directly to 16S ribosomal RNA
DLM49_RS25070	COG0481	GTPase activity
DLM49_RS25120	COG1420	regulation of RNA biosynthetic process
DLM49_RS25125	COG0484	heat shock protein binding
DLM49_RS25145	COG4946	Tricorn protease homolog
DLM49_RS25145	COG0793	Belongs to the peptidase S41A family
DLM49_RS25150	COG0537	adenosine 5'-monophosphoramidase activity
DLM49_RS25155	COG1234	tRNA 3'-trailer cleavage
DLM49_RS25165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DLM49_RS25170	COG4948	Mandelate Racemase Muconate Lactonizing
DLM49_RS25175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DLM49_RS25185	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DLM49_RS25195	COG2315	Protein conserved in bacteria
DLM49_RS25210	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DLM49_RS25240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DLM49_RS25260	COG1309	transcriptional regulator
DLM49_RS25265	COG2409	Drug exporters of the RND superfamily
DLM49_RS25270	COG4585	Histidine kinase
DLM49_RS25315	COG1381	Involved in DNA repair and RecF pathway recombination
DLM49_RS25320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DLM49_RS25335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DLM49_RS25340	COG1121	(ABC) transporter
DLM49_RS25345	COG3443	Belongs to the bacterial solute-binding protein 9 family
DLM49_RS25345	COG0803	Belongs to the bacterial solute-binding protein 9 family
DLM49_RS25350	COG0423	glycine-tRNA ligase activity
DLM49_RS25355	COG0667	Aldo Keto reductase
DLM49_RS25395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DLM49_RS25395	COG0574	Belongs to the PEP-utilizing enzyme family
DLM49_RS25405	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS25410	COG1309	transcriptional regulator
DLM49_RS25420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DLM49_RS25420	COG2146	nitrite reductase [NAD(P)H] activity
DLM49_RS25465	COG0243	molybdopterin cofactor binding
DLM49_RS25470	COG2949	membrane
DLM49_RS25480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DLM49_RS25485	COG0358	DNA primase activity
DLM49_RS25495	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DLM49_RS25500	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS25505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DLM49_RS25525	COG1070	Carbohydrate kinase
DLM49_RS25565	COG1077	Cell shape determining protein MreB Mrl
DLM49_RS25590	COG0825	malonyl-CoA metabolic process
DLM49_RS25590	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DLM49_RS25595	COG0318	PFAM AMP-dependent synthetase and ligase
DLM49_RS25605	COG2186	Transcriptional regulator
DLM49_RS25650	COG2205	protein histidine kinase activity
DLM49_RS25655	COG0745	RESPONSE REGULATOR receiver
DLM49_RS25680	COG1414	Transcriptional regulator
DLM49_RS25685	COG3386	PFAM SMP-30 Gluconolaconase
DLM49_RS25690	COG1819	glycosyl
DLM49_RS25735	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DLM49_RS25745	COG4214	carbohydrate transport
DLM49_RS25755	COG4213	ABC transporter substrate-binding protein
DLM49_RS25790	COG2130	NADP-dependent
DLM49_RS25820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DLM49_RS25825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DLM49_RS25830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DLM49_RS25845	COG1741	Belongs to the pirin family
DLM49_RS25885	COG0789	Transcriptional regulator
DLM49_RS25890	COG0667	Aldo Keto reductase
DLM49_RS25905	COG1309	transcriptional regulator
DLM49_RS25910	COG0477	Major facilitator Superfamily
DLM49_RS25920	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DLM49_RS25965	COG1358	cellular component organization or biogenesis
DLM49_RS26040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DLM49_RS26095	COG4122	O-methyltransferase activity
DLM49_RS26150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DLM49_RS26185	COG0477	Major facilitator Superfamily
DLM49_RS26195	COG2205	protein histidine kinase activity
DLM49_RS26200	COG0745	RESPONSE REGULATOR receiver
DLM49_RS26205	COG2409	Drug exporters of the RND superfamily
DLM49_RS26215	COG0473	3-isopropylmalate dehydrogenase activity
DLM49_RS26255	COG3845	ABC transporter
DLM49_RS26275	COG1657	PFAM Prenyltransferase squalene oxidase
DLM49_RS26285	COG1309	transcriptional regulator
DLM49_RS26290	COG0438	transferase activity, transferring glycosyl groups
DLM49_RS26355	COG0860	N-Acetylmuramoyl-L-alanine amidase
DLM49_RS26355	COG2247	cell wall binding repeat
DLM49_RS26375	COG2197	response regulator
DLM49_RS26380	COG4585	Histidine kinase
DLM49_RS26385	COG2030	dehydratase
DLM49_RS26395	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DLM49_RS26420	COG0800	Aldolase
DLM49_RS26425	COG3022	response to hydroperoxide
DLM49_RS26440	COG0789	Transcriptional regulator
DLM49_RS26505	COG2255	four-way junction helicase activity
DLM49_RS26530	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS26535	COG3540	Alkaline phosphatase
DLM49_RS26545	COG2814	Major facilitator Superfamily
DLM49_RS26550	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DLM49_RS26590	COG1120	ATPase activity
DLM49_RS26595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DLM49_RS26600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DLM49_RS26635	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DLM49_RS26675	COG1994	Peptidase M50
DLM49_RS26695	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DLM49_RS26700	COG0477	Major facilitator Superfamily
DLM49_RS26715	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DLM49_RS26715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DLM49_RS26730	COG1959	2 iron, 2 sulfur cluster binding
DLM49_RS26735	COG0174	glutamine synthetase
DLM49_RS26740	COG2318	DinB family
DLM49_RS26760	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DLM49_RS26770	COG1609	Transcriptional regulator
DLM49_RS26775	COG2182	Extracellular solute-binding protein
DLM49_RS26780	COG1175	transmembrane transport
DLM49_RS26785	COG3833	ABC-type maltose transport systems, permease component
DLM49_RS26790	COG0366	Alpha amylase catalytic
DLM49_RS26815	COG1309	transcriptional regulator
DLM49_RS26860	COG4585	Histidine kinase
DLM49_RS26865	COG2197	response regulator
DLM49_RS26875	COG0577	efflux transmembrane transporter activity
DLM49_RS26875	COG1136	(ABC) transporter
DLM49_RS26890	COG0174	glutamine synthetase
DLM49_RS26910	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DLM49_RS26915	COG0321	lipoyl(octanoyl) transferase activity
DLM49_RS26930	COG1090	epimerase
DLM49_RS26960	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DLM49_RS26975	COG0508	dehydrogenase complex catalyzes the overall conversion of
DLM49_RS26980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DLM49_RS26985	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DLM49_RS27000	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DLM49_RS27010	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DLM49_RS27030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DLM49_RS27055	COG2197	response regulator
DLM49_RS27060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DLM49_RS27065	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DLM49_RS27090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DLM49_RS27100	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DLM49_RS27105	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DLM49_RS27115	COG1376	ErfK ybiS ycfS ynhG family protein
DLM49_RS27125	COG1845	cytochrome c oxidase, subunit III
DLM49_RS27130	COG2010	Cytochrome c
DLM49_RS27135	COG0723	plastoquinol--plastocyanin reductase activity
DLM49_RS27140	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DLM49_RS27145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DLM49_RS27150	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DLM49_RS27225	COG1940	carbohydrate kinase activity
DLM49_RS27285	COG4585	Histidine kinase
DLM49_RS27290	COG2197	response regulator
DLM49_RS27295	COG0205	6-phosphofructokinase activity
DLM49_RS27315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DLM49_RS27330	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DLM49_RS27340	COG2193	ferroxidase activity
DLM49_RS27345	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DLM49_RS27350	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DLM49_RS27355	COG0515	serine threonine protein kinase
DLM49_RS27355	COG2815	serine threonine protein kinase
DLM49_RS27365	COG2022	thiamine diphosphate biosynthetic process
DLM49_RS27375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DLM49_RS27375	COG2022	thiamine diphosphate biosynthetic process
DLM49_RS27395	COG0352	thiamine-phosphate diphosphorylase activity
DLM49_RS27410	COG1233	COG1233 Phytoene dehydrogenase and related
DLM49_RS27415	COG1309	transcriptional regulator
DLM49_RS27420	COG1511	domain protein
DLM49_RS27425	COG4133	protoheme IX ABC transporter activity
DLM49_RS27455	COG0714	Associated with various cellular activities
DLM49_RS27465	COG0275	rRNA processing
DLM49_RS27480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DLM49_RS27490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DLM49_RS27495	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DLM49_RS27505	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DLM49_RS27510	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DLM49_RS27515	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DLM49_RS27520	COG1496	oxidoreductase activity
DLM49_RS27530	COG1799	cell septum assembly
DLM49_RS27540	COG3599	regulation of cell shape
DLM49_RS27545	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DLM49_RS27560	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DLM49_RS27615	COG0587	DNA-directed DNA polymerase activity
DLM49_RS27620	COG1432	Conserved Protein
DLM49_RS27625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DLM49_RS27630	COG1309	transcriptional regulator
DLM49_RS27670	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DLM49_RS27675	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DLM49_RS27680	COG0131	Imidazoleglycerol-phosphate dehydratase
DLM49_RS27685	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DLM49_RS27690	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DLM49_RS27695	COG0251	oxidation-reduction process
DLM49_RS27700	COG0107	imidazoleglycerol-phosphate synthase activity
DLM49_RS27715	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DLM49_RS27720	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DLM49_RS27740	COG0134	indole-3-glycerol-phosphate synthase activity
DLM49_RS27750	COG0133	tryptophan synthase activity
DLM49_RS27755	COG0159	tryptophan synthase activity
DLM49_RS27765	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DLM49_RS27775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DLM49_RS27795	COG1397	ADP-ribosylglycohydrolase
DLM49_RS27805	COG0067	glutamate synthase
DLM49_RS27805	COG0070	glutamate synthase
DLM49_RS27805	COG0069	glutamate synthase activity
DLM49_RS27830	COG2304	oxidoreductase activity
DLM49_RS27840	COG0287	Prephenate dehydrogenase
DLM49_RS27840	COG1605	Chorismate mutase
DLM49_RS27845	COG0745	RESPONSE REGULATOR receiver
DLM49_RS27865	COG0737	Belongs to the 5'-nucleotidase family
DLM49_RS27920	COG2050	protein possibly involved in aromatic compounds catabolism
DLM49_RS27965	COG1643	Atp-dependent helicase
DLM49_RS27975	COG0539	negative regulation of cytoplasmic translation
DLM49_RS27985	COG0237	dephospho-CoA kinase activity
DLM49_RS28000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DLM49_RS28010	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DLM49_RS28020	COG2267	carboxylic ester hydrolase activity
DLM49_RS28045	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DLM49_RS28065	COG0402	S-adenosylhomocysteine deaminase activity
DLM49_RS28130	COG0598	Magnesium transport protein CorA
DLM49_RS28135	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DLM49_RS28135	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DLM49_RS28140	COG2313	pseudouridylate synthase activity
DLM49_RS28150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DLM49_RS28155	COG0584	glycerophosphoryl diester phosphodiesterase
DLM49_RS28165	COG0556	nucleotide-excision repair
DLM49_RS28185	COG0387	Pfam Sodium calcium exchanger
DLM49_RS28190	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DLM49_RS28205	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DLM49_RS28215	COG1609	Transcriptional regulator
DLM49_RS28220	COG0723	plastoquinol--plastocyanin reductase activity
DLM49_RS28230	COG0322	excinuclease ABC activity
DLM49_RS28235	COG1660	Displays ATPase and GTPase activities
DLM49_RS28240	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DLM49_RS28245	COG1481	regulation of sporulation
DLM49_RS28255	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DLM49_RS28260	COG0126	phosphoglycerate kinase activity
DLM49_RS28265	COG0149	triose-phosphate isomerase activity
DLM49_RS28270	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DLM49_RS28280	COG0166	Belongs to the GPI family
DLM49_RS28290	COG0577	efflux transmembrane transporter activity
DLM49_RS28290	COG1136	(ABC) transporter
DLM49_RS28295	COG1695	Transcriptional regulator
DLM49_RS28305	COG0366	Alpha amylase catalytic
DLM49_RS28315	COG1175	transmembrane transport
DLM49_RS28320	COG0395	ABC-type sugar transport system, permease component
DLM49_RS28325	COG0363	glucosamine-6-phosphate deaminase activity
DLM49_RS28340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DLM49_RS28355	COG0109	protoheme IX farnesyltransferase activity
DLM49_RS28385	COG1131	(ABC) transporter
DLM49_RS28400	COG0719	Fe-S assembly protein
DLM49_RS28410	COG0396	ATPase activity
DLM49_RS28415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DLM49_RS28420	COG0822	iron-sulfur transferase activity
DLM49_RS28425	COG2151	metal-sulfur cluster biosynthetic enzyme
DLM49_RS28430	COG2076	Multidrug Resistance protein
DLM49_RS28435	COG3226	Transcriptional regulator
DLM49_RS28440	COG2171	N-acyltransferase activity
DLM49_RS28450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DLM49_RS28490	COG0667	Aldo Keto reductase
DLM49_RS28495	COG1063	alcohol dehydrogenase
DLM49_RS28500	COG0395	ABC-type sugar transport system, permease component
DLM49_RS28510	COG2182	Extracellular solute-binding protein
DLM49_RS28520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DLM49_RS28525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DLM49_RS28550	COG1802	Transcriptional regulator
DLM49_RS28555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DLM49_RS28565	COG2252	PERMEase
DLM49_RS28570	COG0768	penicillin binding
DLM49_RS28585	COG1414	Transcriptional regulator
DLM49_RS28595	COG2197	response regulator
DLM49_RS28600	COG4585	Histidine kinase
DLM49_RS28620	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DLM49_RS28625	COG5285	phytanoyl-CoA dioxygenase
DLM49_RS28630	COG1917	Cupin 2, conserved barrel domain protein
DLM49_RS28635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DLM49_RS28640	COG0456	acetyltransferase
DLM49_RS28645	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DLM49_RS28650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DLM49_RS28655	COG0765	amino acid transport
DLM49_RS28750	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DLM49_RS28765	COG0235	Class ii aldolase
DLM49_RS28785	COG0488	(ABC) transporter
DLM49_RS28795	COG1024	Enoyl-CoA hydratase
DLM49_RS28835	COG3387	PFAM Glycoside hydrolase 15-related
DLM49_RS28865	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DLM49_RS28875	COG1404	Belongs to the peptidase S8 family
DLM49_RS28890	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DLM49_RS28895	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DLM49_RS28915	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DLM49_RS28930	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS28940	COG2186	Transcriptional regulator
DLM49_RS28960	COG0588	phosphoglycerate mutase activity
DLM49_RS28965	COG3830	Belongs to the UPF0237 family
DLM49_RS28965	COG0560	Phosphoserine phosphatase
DLM49_RS28975	COG1131	(ABC) transporter
DLM49_RS28975	COG0842	Transport permease protein
DLM49_RS28975	COG1716	ATPase activity
DLM49_RS28995	COG2197	response regulator
DLM49_RS29010	COG1119	ATPase activity
DLM49_RS29030	COG1881	PFAM PEBP family protein
DLM49_RS29040	COG2094	Belongs to the DNA glycosylase MPG family
DLM49_RS29075	COG0647	UMP catabolic process
DLM49_RS29080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DLM49_RS29085	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DLM49_RS29090	COG1120	ATPase activity
DLM49_RS29110	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DLM49_RS29115	COG0497	DNA recombination
DLM49_RS29135	COG3387	PFAM Glycoside hydrolase 15-related
DLM49_RS29145	COG0504	CTP synthase activity
DLM49_RS29150	COG0494	nUDIX hydrolase
DLM49_RS29160	COG0686	Belongs to the AlaDH PNT family
DLM49_RS29175	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DLM49_RS29180	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DLM49_RS29185	COG1187	pseudouridine synthase activity
DLM49_RS29190	COG1051	belongs to the nudix hydrolase family
DLM49_RS29190	COG1056	cytidyltransferase-related domain
DLM49_RS29200	COG3541	Predicted nucleotidyltransferase
DLM49_RS29210	COG0723	plastoquinol--plastocyanin reductase activity
DLM49_RS29225	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DLM49_RS29235	COG1160	GTP binding
DLM49_RS29250	COG1652	LysM domain
DLM49_RS29295	COG0671	phosphoesterase, PA-phosphatase related
DLM49_RS29305	COG0477	Major facilitator Superfamily
DLM49_RS29310	COG1960	acyl-CoA dehydrogenase activity
DLM49_RS29315	COG1799	cell septum assembly
DLM49_RS29330	COG0330	HflC and HflK could
DLM49_RS29345	COG0587	DNA-directed DNA polymerase activity
DLM49_RS29400	COG1725	Transcriptional regulator
DLM49_RS29415	COG0726	polysaccharide deacetylase
DLM49_RS29420	COG1216	Glycosyl transferase, family 2
DLM49_RS29430	COG2755	lipolytic protein G-D-S-L family
DLM49_RS29455	COG1595	DNA-templated transcription, initiation
DLM49_RS29490	COG2188	Transcriptional regulator
DLM49_RS29495	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DLM49_RS29505	COG1309	transcriptional regulator
DLM49_RS29510	COG0243	molybdopterin cofactor binding
DLM49_RS29535	COG0640	Transcriptional regulator
DLM49_RS29545	COG1960	acyl-CoA dehydrogenase activity
DLM49_RS29565	COG0789	Transcriptional regulator
DLM49_RS29580	COG3876	Protein conserved in bacteria
DLM49_RS29620	COG2149	membrane
DLM49_RS29625	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DLM49_RS29655	COG3265	gluconokinase activity
DLM49_RS29660	COG2186	Transcriptional regulator
DLM49_RS29665	COG3012	SEC-C Motif Domain Protein
DLM49_RS29675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DLM49_RS29705	COG0667	Aldo Keto reductase
DLM49_RS29710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DLM49_RS29720	COG0598	Magnesium transport protein CorA
DLM49_RS29740	COG0215	cysteine-tRNA ligase activity
DLM49_RS29750	COG0456	acetyltransferase
DLM49_RS29755	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DLM49_RS29760	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DLM49_RS29765	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DLM49_RS29770	COG1414	Transcriptional regulator
DLM49_RS29775	COG0646	methionine synthase
DLM49_RS29775	COG1410	methionine synthase
DLM49_RS29780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DLM49_RS29785	COG4166	transmembrane transport
DLM49_RS29790	COG4166	transmembrane transport
DLM49_RS29795	COG2197	response regulator
DLM49_RS29805	COG1994	Peptidase M50
DLM49_RS29805	COG0517	IMP dehydrogenase activity
DLM49_RS29830	COG1222	aaa ATPase
DLM49_RS29835	COG4122	O-methyltransferase activity
DLM49_RS29850	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DLM49_RS29855	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DLM49_RS29860	COG1609	Transcriptional regulator
DLM49_RS29870	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DLM49_RS29875	COG0545	Peptidyl-prolyl cis-trans isomerase
DLM49_RS29885	COG2378	regulation of single-species biofilm formation
DLM49_RS29905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DLM49_RS29910	COG0805	protein transport
DLM49_RS29950	COG0564	pseudouridine synthase activity
DLM49_RS29965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DLM49_RS29970	COG0517	IMP dehydrogenase activity
DLM49_RS29970	COG4175	Glycine betaine
DLM49_RS29975	COG4176	ABC-type proline glycine betaine transport system permease component
DLM49_RS29995	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DLM49_RS30000	COG0531	amino acid
DLM49_RS30010	COG0174	glutamine synthetase
DLM49_RS30015	COG1012	belongs to the aldehyde dehydrogenase family
DLM49_RS30060	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DLM49_RS30065	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DLM49_RS30070	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DLM49_RS30075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DLM49_RS30080	COG5002	protein histidine kinase activity
DLM49_RS30085	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DLM49_RS30090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DLM49_RS30090	COG0072	phenylalanine-tRNA ligase activity
DLM49_RS30115	COG1649	PFAM Uncharacterised BCR, COG1649
DLM49_RS30130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DLM49_RS30130	COG0574	Belongs to the PEP-utilizing enzyme family
DLM49_RS30145	COG0697	spore germination
DLM49_RS30170	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DLM49_RS30175	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DLM49_RS30180	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DLM49_RS30185	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DLM49_RS30190	COG1438	arginine binding
DLM49_RS30215	COG0137	argininosuccinate synthase activity
DLM49_RS30220	COG0165	Argininosuccinate lyase
DLM49_RS30230	COG0318	PFAM AMP-dependent synthetase and ligase
DLM49_RS30230	COG0204	Acyl-transferase
DLM49_RS30235	COG0584	glycerophosphoryl diester phosphodiesterase
DLM49_RS30260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DLM49_RS30265	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DLM49_RS30270	COG2011	ABC-type metal ion transport system permease component
DLM49_RS30275	COG1464	Belongs to the NlpA lipoprotein family
DLM49_RS30290	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DLM49_RS30295	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DLM49_RS30295	COG1648	precorrin-2 dehydrogenase activity
DLM49_RS30355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DLM49_RS30415	COG2176	DNA-directed DNA polymerase activity
DLM49_RS30415	COG5002	protein histidine kinase activity
DLM49_RS30430	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DLM49_RS30450	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DLM49_RS30455	COG1560	Kdo2-lipid A biosynthetic process
DLM49_RS30460	COG0438	transferase activity, transferring glycosyl groups
DLM49_RS30470	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DLM49_RS30475	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DLM49_RS30480	COG0217	transcriptional regulatory protein
DLM49_RS30485	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DLM49_RS30490	COG0632	four-way junction helicase activity
DLM49_RS30495	COG2255	four-way junction helicase activity
DLM49_RS30505	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DLM49_RS30510	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DLM49_RS30515	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DLM49_RS30525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DLM49_RS30530	COG1196	nuclear chromosome segregation
DLM49_RS30535	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DLM49_RS30545	COG0124	histidyl-tRNA synthetase
DLM49_RS30560	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DLM49_RS30575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DLM49_RS30580	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DLM49_RS30595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DLM49_RS30605	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DLM49_RS30610	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DLM49_RS30615	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DLM49_RS30625	COG0006	proline dipeptidase activity
DLM49_RS30630	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DLM49_RS30635	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DLM49_RS30645	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DLM49_RS30650	COG0540	Belongs to the ATCase OTCase family
DLM49_RS30655	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DLM49_RS30665	COG0505	Belongs to the CarA family
DLM49_RS30670	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DLM49_RS30675	COG0167	dihydroorotate dehydrogenase activity
DLM49_RS30680	COG0284	orotidine-5'-phosphate decarboxylase activity
DLM49_RS30690	COG0194	GDP metabolic process
DLM49_RS30695	COG1758	RNA polymerase activity
DLM49_RS30705	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DLM49_RS30720	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DLM49_RS30730	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DLM49_RS30735	COG2390	Transcriptional regulator
DLM49_RS30745	COG0531	amino acid
DLM49_RS30760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DLM49_RS30785	COG2233	PERMEase
DLM49_RS30800	COG1846	Transcriptional regulator
DLM49_RS30800	COG1940	carbohydrate kinase activity
DLM49_RS30805	COG1090	epimerase
DLM49_RS30820	COG3201	nicotinamide mononucleotide transporter
DLM49_RS30825	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DLM49_RS30825	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DLM49_RS30830	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DLM49_RS30835	COG0140	phosphoribosyl-ATP diphosphatase activity
DLM49_RS30840	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DLM49_RS30890	COG1960	acyl-CoA dehydrogenase activity
DLM49_RS30915	COG1216	Glycosyl transferase, family 2
DLM49_RS30920	COG3030	protein affecting phage T7 exclusion by the F plasmid
DLM49_RS30930	COG2270	Major facilitator Superfamily
DLM49_RS30940	COG2364	Membrane
DLM49_RS30970	COG1984	allophanate hydrolase subunit 2
DLM49_RS30975	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DLM49_RS30980	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DLM49_RS30985	COG4336	lyase activity
DLM49_RS30990	COG2814	Major facilitator Superfamily
DLM49_RS31025	COG2018	Roadblock/LC7 domain
DLM49_RS31045	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DLM49_RS31050	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DLM49_RS31055	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DLM49_RS31070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DLM49_RS31080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DLM49_RS31110	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DLM49_RS31130	COG1716	ATPase activity
DLM49_RS31150	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DLM49_RS31160	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DLM49_RS31160	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DLM49_RS31185	COG1609	Transcriptional regulator
DLM49_RS31210	COG0384	phenazine biosynthesis protein PhzF
DLM49_RS31250	COG0697	spore germination
DLM49_RS31300	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DLM49_RS31325	COG2318	DinB family
DLM49_RS31335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DLM49_RS31345	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DLM49_RS31370	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS31395	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DLM49_RS31415	COG0477	Major facilitator Superfamily
DLM49_RS31420	COG0129	dihydroxy-acid dehydratase activity
DLM49_RS31425	COG3976	FMN-binding domain protein
DLM49_RS31425	COG1053	succinate dehydrogenase
DLM49_RS31470	COG1968	undecaprenyl-diphosphatase activity
DLM49_RS31485	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DLM49_RS31520	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
DLM49_RS31535	COG0110	maltose O-acetyltransferase activity
DLM49_RS31560	COG0640	Transcriptional regulator
DLM49_RS31570	COG1832	CoA-binding protein
DLM49_RS31575	COG0215	cysteine-tRNA ligase activity
DLM49_RS31585	COG1739	Uncharacterized protein family UPF0029
DLM49_RS31635	COG1960	acyl-CoA dehydrogenase activity
DLM49_RS31655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DLM49_RS31665	COG0318	PFAM AMP-dependent synthetase and ligase
DLM49_RS31675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DLM49_RS31685	COG0420	3'-5' exonuclease activity
DLM49_RS31690	COG0419	ATPase involved in DNA repair
DLM49_RS31695	COG1522	sequence-specific DNA binding
DLM49_RS31710	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS31725	COG0626	cystathionine gamma-synthase activity
DLM49_RS31745	COG1595	DNA-templated transcription, initiation
DLM49_RS31750	COG2188	Transcriptional regulator
DLM49_RS31760	COG1940	carbohydrate kinase activity
DLM49_RS31765	COG2197	response regulator
DLM49_RS31770	COG4585	Histidine kinase
DLM49_RS31795	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DLM49_RS31815	COG0456	acetyltransferase
DLM49_RS31820	COG0577	efflux transmembrane transporter activity
DLM49_RS31840	COG2226	methyltransferase
DLM49_RS31845	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DLM49_RS31850	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DLM49_RS31855	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DLM49_RS31860	COG0156	8-amino-7-oxononanoate synthase activity
DLM49_RS31890	COG0740	serine-type endopeptidase activity
DLM49_RS31905	COG1309	transcriptional regulator
DLM49_RS31910	COG0831	urea catabolic process
DLM49_RS31915	COG0832	Belongs to the urease beta subunit family
DLM49_RS31920	COG0804	urea catabolic process
DLM49_RS31930	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DLM49_RS31935	COG0829	nickel cation binding
DLM49_RS31940	COG0204	Acyl-transferase
DLM49_RS31945	COG0698	ribose 5-phosphate isomerase
DLM49_RS31955	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DLM49_RS31960	COG1834	amidinotransferase
DLM49_RS31965	COG1522	sequence-specific DNA binding
DLM49_RS31980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DLM49_RS31985	COG3275	phosphorelay sensor kinase activity
DLM49_RS32000	COG0205	6-phosphofructokinase activity
DLM49_RS32005	COG3442	glutamine amidotransferase
DLM49_RS32010	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DLM49_RS32015	COG0242	peptide deformylase activity
DLM49_RS32025	COG1960	acyl-CoA dehydrogenase activity
DLM49_RS32040	COG1012	belongs to the aldehyde dehydrogenase family
DLM49_RS32045	COG0494	nUDIX hydrolase
DLM49_RS32050	COG1793	dna ligase
DLM49_RS32070	COG1960	acyl-CoA dehydrogenase activity
DLM49_RS32075	COG1960	acyl-CoA dehydrogenase activity
DLM49_RS32115	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DLM49_RS32180	COG2018	Roadblock/LC7 domain
DLM49_RS32190	COG1946	Acyl-CoA thioesterase
DLM49_RS32205	COG0254	rRNA binding
DLM49_RS32215	COG1132	(ABC) transporter
DLM49_RS32220	COG1132	(ABC) transporter
DLM49_RS32230	COG1132	(ABC) transporter
DLM49_RS32240	COG2072	flavoprotein involved in K transport
DLM49_RS32245	COG0432	Pfam Uncharacterised protein family UPF0047
DLM49_RS32250	COG0589	response to stress
DLM49_RS32295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DLM49_RS32310	COG2706	6-phosphogluconolactonase activity
DLM49_RS32330	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DLM49_RS32360	COG1250	3-hydroxyacyl-CoA dehydrogenase
DLM49_RS32445	COG1960	acyl-CoA dehydrogenase activity
DLM49_RS32455	COG1902	pentaerythritol trinitrate reductase activity
DLM49_RS32460	COG0640	Transcriptional regulator
DLM49_RS32480	COG1309	transcriptional regulator
DLM49_RS32485	COG0671	phosphoesterase, PA-phosphatase related
DLM49_RS32520	COG0584	glycerophosphoryl diester phosphodiesterase
DLM49_RS32570	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DLM49_RS32590	COG3655	Transcriptional regulator
DLM49_RS32595	COG0515	serine threonine protein kinase
DLM49_RS32595	COG2815	serine threonine protein kinase
DLM49_RS32615	COG1660	Displays ATPase and GTPase activities
DLM49_RS32640	COG4585	Histidine kinase
DLM49_RS32645	COG2197	response regulator
DLM49_RS32660	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS32665	COG2223	nitrite transmembrane transporter activity
DLM49_RS32695	COG4565	transcriptional regulatory protein
DLM49_RS32715	COG3387	PFAM Glycoside hydrolase 15-related
DLM49_RS32720	COG1349	DNA-binding transcription factor activity
DLM49_RS32725	COG2813	Specifically methylates the guanine in position
DLM49_RS32735	COG1940	carbohydrate kinase activity
DLM49_RS32765	COG1136	(ABC) transporter
DLM49_RS32770	COG0577	efflux transmembrane transporter activity
DLM49_RS32795	COG1349	DNA-binding transcription factor activity
DLM49_RS32815	COG0633	Ferredoxin
DLM49_RS32815	COG3217	Mosc domain protein beta barrel domain protein
DLM49_RS32830	COG0463	Glycosyl transferase, family 2
DLM49_RS32835	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DLM49_RS32860	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS32885	COG1278	Cold shock
DLM49_RS32895	COG3424	synthase
DLM49_RS32900	COG1024	Enoyl-CoA hydratase
DLM49_RS32905	COG1024	Enoyl-CoA hydratase
DLM49_RS32935	COG1132	(ABC) transporter
DLM49_RS32965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DLM49_RS32990	COG1136	(ABC) transporter
DLM49_RS33010	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DLM49_RS33020	COG3119	arylsulfatase activity
DLM49_RS33070	COG4221	oxidoreductase activity
DLM49_RS33095	COG2409	Drug exporters of the RND superfamily
DLM49_RS33100	COG1846	Transcriptional regulator
DLM49_RS33110	COG1012	belongs to the aldehyde dehydrogenase family
DLM49_RS33145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DLM49_RS33200	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DLM49_RS33205	COG1993	acr, cog1993
DLM49_RS33210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DLM49_RS33220	COG2186	Transcriptional regulator
DLM49_RS33230	COG2066	Belongs to the glutaminase family
DLM49_RS33235	COG1686	Belongs to the peptidase S11 family
DLM49_RS33240	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DLM49_RS33250	COG2188	Transcriptional regulator
DLM49_RS33255	COG3458	cephalosporin-C deacetylase activity
DLM49_RS33265	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DLM49_RS33270	COG2890	protein-(glutamine-N5) methyltransferase activity
DLM49_RS33285	COG0446	pyridine nucleotide-disulphide oxidoreductase
DLM49_RS33285	COG1902	pentaerythritol trinitrate reductase activity
DLM49_RS33315	COG1461	Dihydroxyacetone kinase
DLM49_RS33320	COG2376	Dihydroxyacetone kinase
DLM49_RS33340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DLM49_RS33375	COG0709	Synthesizes selenophosphate from selenide and ATP
DLM49_RS33380	COG3383	formate dehydrogenase (NAD+) activity
DLM49_RS33380	COG0243	molybdopterin cofactor binding
DLM49_RS33385	COG0243	molybdopterin cofactor binding
DLM49_RS33385	COG3383	formate dehydrogenase (NAD+) activity
DLM49_RS33395	COG0437	4 iron, 4 sulfur cluster binding
DLM49_RS33425	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DLM49_RS33545	COG0346	lactoylglutathione lyase activity
DLM49_RS33550	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DLM49_RS33560	COG0583	DNA-binding transcription factor activity
DLM49_RS33565	COG0667	Aldo Keto reductase
DLM49_RS33595	COG1191	sigma factor activity
DLM49_RS33605	COG0740	serine-type endopeptidase activity
DLM49_RS33610	COG0740	serine-type endopeptidase activity
DLM49_RS33615	COG3547	Transposase (IS116 IS110 IS902 family)
DLM49_RS33645	COG0328	RNA-DNA hybrid ribonuclease activity
DLM49_RS33650	COG2304	oxidoreductase activity
DLM49_RS33660	COG0667	Aldo Keto reductase
DLM49_RS33680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DLM49_RS33690	COG0515	serine threonine protein kinase
DLM49_RS33690	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DLM49_RS33695	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DLM49_RS33705	COG2340	Cysteine-rich secretory protein family
DLM49_RS33740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DLM49_RS33790	COG1819	glycosyl
DLM49_RS33800	COG1982	Orn Lys Arg decarboxylase major
DLM49_RS33835	COG1252	NADH dehydrogenase
DLM49_RS33855	COG1366	Belongs to the anti-sigma-factor antagonist family
DLM49_RS33860	COG1366	Belongs to the anti-sigma-factor antagonist family
DLM49_RS33890	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DLM49_RS33895	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DLM49_RS33900	COG3281	Trehalose synthase
DLM49_RS33910	COG0366	Alpha amylase catalytic
DLM49_RS33950	COG0181	hydroxymethylbilane synthase activity
DLM49_RS33960	COG3285	dna ligase
DLM49_RS33960	COG1793	dna ligase
DLM49_RS33965	COG0583	DNA-binding transcription factor activity
DLM49_RS33970	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS34010	COG0640	Transcriptional regulator
DLM49_RS34015	COG2226	methyltransferase
DLM49_RS34030	COG3285	dna ligase
DLM49_RS34030	COG1793	dna ligase
DLM49_RS34035	COG0656	L-ascorbic acid biosynthetic process
DLM49_RS34045	COG0009	L-threonylcarbamoyladenylate synthase
DLM49_RS34065	COG0753	catalase activity
DLM49_RS34120	COG3540	Alkaline phosphatase
DLM49_RS34160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DLM49_RS34165	COG1120	ATPase activity
DLM49_RS34195	COG1132	(ABC) transporter
DLM49_RS34200	COG1063	alcohol dehydrogenase
DLM49_RS34210	COG0659	secondary active sulfate transmembrane transporter activity
DLM49_RS34225	COG2264	protein methyltransferase activity
DLM49_RS34235	COG1295	ribonuclease BN
DLM49_RS34240	COG0456	acetyltransferase
DLM49_RS34245	COG3397	chitin binding
DLM49_RS34255	COG2409	Drug exporters of the RND superfamily
DLM49_RS34315	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS34345	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DLM49_RS34395	COG0596	Alpha beta hydrolase
DLM49_RS34405	COG0438	transferase activity, transferring glycosyl groups
DLM49_RS34440	COG2182	Extracellular solute-binding protein
DLM49_RS34445	COG1175	transmembrane transport
DLM49_RS34450	COG0395	ABC-type sugar transport system, permease component
DLM49_RS34465	COG3507	Belongs to the glycosyl hydrolase 43 family
DLM49_RS34495	COG0277	FAD linked oxidase domain protein
DLM49_RS34500	COG1597	lipid kinase activity
DLM49_RS34535	COG3250	beta-galactosidase activity
DLM49_RS34545	COG0667	Aldo Keto reductase
DLM49_RS34550	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS34555	COG1309	transcriptional regulator
DLM49_RS34605	COG0309	Hydrogenase expression formation protein (HypE)
DLM49_RS34610	COG0409	Hydrogenase expression formation protein
DLM49_RS34625	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DLM49_RS34630	COG0375	protein maturation
DLM49_RS34670	COG1024	Enoyl-CoA hydratase
DLM49_RS34670	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DLM49_RS34705	COG1357	PFAM Pentapeptide repeats (8 copies)
DLM49_RS34730	COG2124	cytochrome p450
DLM49_RS34740	COG0142	geranyltranstransferase activity
DLM49_RS34780	COG0535	radical SAM domain protein
DLM49_RS34810	COG1140	nitrate reductase beta subunit
DLM49_RS34830	COG1017	nitric oxide dioxygenase activity
DLM49_RS34830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DLM49_RS34835	COG0494	nUDIX hydrolase
DLM49_RS34855	COG1053	succinate dehydrogenase
DLM49_RS34860	COG1595	DNA-templated transcription, initiation
DLM49_RS34890	COG3119	arylsulfatase activity
DLM49_RS34895	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DLM49_RS34900	COG0577	efflux transmembrane transporter activity
DLM49_RS34900	COG1136	(ABC) transporter
DLM49_RS34910	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DLM49_RS34915	COG1733	regulation of RNA biosynthetic process
DLM49_RS34930	COG2259	Doxx family
DLM49_RS34945	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DLM49_RS34980	COG0702	epimerase
DLM49_RS35005	COG1172	Belongs to the binding-protein-dependent transport system permease family
DLM49_RS35010	COG1172	Belongs to the binding-protein-dependent transport system permease family
DLM49_RS35015	COG1129	ABC transporter
DLM49_RS35020	COG1879	ABC-type sugar transport system periplasmic component
DLM49_RS35025	COG1609	Transcriptional regulator
DLM49_RS35065	COG1733	regulation of RNA biosynthetic process
DLM49_RS35080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DLM49_RS35080	COG0574	Belongs to the PEP-utilizing enzyme family
DLM49_RS35090	COG1063	alcohol dehydrogenase
DLM49_RS35115	COG0300	oxidoreductase activity
DLM49_RS35125	COG2181	nitrate reductase activity
DLM49_RS35135	COG1140	nitrate reductase beta subunit
DLM49_RS35145	COG2132	Multicopper oxidase
DLM49_RS35150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DLM49_RS35165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DLM49_RS35170	COG3938	Belongs to the proline racemase family
DLM49_RS35200	COG0667	Aldo Keto reductase
DLM49_RS35220	COG0714	Associated with various cellular activities
DLM49_RS35235	COG0488	(ABC) transporter
DLM49_RS35245	COG0644	oxidoreductase
DLM49_RS35255	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DLM49_RS35270	COG2264	protein methyltransferase activity
DLM49_RS35350	COG2259	Doxx family
DLM49_RS35360	COG2318	DinB family
DLM49_RS35395	COG0702	epimerase
DLM49_RS35420	COG3940	Belongs to the glycosyl hydrolase 43 family
DLM49_RS35430	COG0667	Aldo Keto reductase
DLM49_RS35435	COG1309	transcriptional regulator
DLM49_RS35455	COG2045	Belongs to the ComB family
DLM49_RS35505	COG4977	sequence-specific DNA binding
DLM49_RS35510	COG0745	RESPONSE REGULATOR receiver
DLM49_RS35515	COG2205	protein histidine kinase activity
DLM49_RS35580	COG2770	Histidine kinase
DLM49_RS35580	COG2208	phosphoserine phosphatase activity
DLM49_RS35595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DLM49_RS35605	COG1595	DNA-templated transcription, initiation
DLM49_RS35610	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DLM49_RS35640	COG1472	Belongs to the glycosyl hydrolase 3 family
DLM49_RS35645	COG1302	Protein conserved in bacteria
DLM49_RS35695	COG0783	Belongs to the Dps family
DLM49_RS35700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DLM49_RS35710	COG2319	Wd-40 repeat
DLM49_RS35710	COG4249	Peptidase C14 caspase catalytic subunit p20
DLM49_RS35785	COG2197	response regulator
DLM49_RS35790	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DLM49_RS35810	COG1733	regulation of RNA biosynthetic process
DLM49_RS35820	COG2378	regulation of single-species biofilm formation
DLM49_RS35840	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS35845	COG1959	2 iron, 2 sulfur cluster binding
DLM49_RS35850	COG1609	Transcriptional regulator
DLM49_RS35860	COG1175	transmembrane transport
DLM49_RS35870	COG1472	Belongs to the glycosyl hydrolase 3 family
DLM49_RS35880	COG0129	dihydroxy-acid dehydratase activity
DLM49_RS35900	COG2188	Transcriptional regulator
DLM49_RS35920	COG2318	DinB family
DLM49_RS35930	COG0741	lytic transglycosylase activity
DLM49_RS35930	COG0739	heme binding
DLM49_RS35930	COG1196	nuclear chromosome segregation
DLM49_RS35950	COG0730	response to heat
DLM49_RS35955	COG1937	Protein conserved in bacteria
DLM49_RS35960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DLM49_RS35965	COG1309	transcriptional regulator
DLM49_RS35985	COG0596	Alpha beta hydrolase
DLM49_RS35990	COG1335	isochorismatase
DLM49_RS36015	COG0477	Major facilitator Superfamily
DLM49_RS36025	COG2309	aminopeptidase activity
DLM49_RS36035	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DLM49_RS36040	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS36045	COG1902	pentaerythritol trinitrate reductase activity
DLM49_RS36050	COG1846	Transcriptional regulator
DLM49_RS36075	COG0442	prolyl-tRNA aminoacylation
DLM49_RS36080	COG3321	synthase
DLM49_RS36080	COG0604	alcohol dehydrogenase
DLM49_RS36080	COG1028	Short-chain dehydrogenase reductase Sdr
DLM49_RS36120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DLM49_RS36245	COG2188	Transcriptional regulator
DLM49_RS36365	COG1660	Displays ATPase and GTPase activities
DLM49_RS36395	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DLM49_RS36495	COG2188	Transcriptional regulator