locus-tag	class	description
C4B68_RS00155	COG1028	Short-chain dehydrogenase reductase Sdr
C4B68_RS00180	COG2801	Transposase and inactivated derivatives
C4B68_RS00185	COG2801	Transposase and inactivated derivatives
C4B68_RS00235	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4B68_RS00245	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4B68_RS00255	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C4B68_RS00260	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4B68_RS00270	COG0285	dihydrofolate synthase activity
C4B68_RS00280	COG1469	GTP cyclohydrolase I activity
C4B68_RS00295	COG2318	DinB family
C4B68_RS00305	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C4B68_RS00310	COG2259	Doxx family
C4B68_RS00375	COG1132	(ABC) transporter
C4B68_RS00405	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4B68_RS00425	COG2175	clavaminate synthase activity
C4B68_RS00445	COG1324	tolerance protein
C4B68_RS00490	COG4221	oxidoreductase activity
C4B68_RS00540	COG1857	crispr-associated protein
C4B68_RS00560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4B68_RS00575	COG0431	NADPH-dependent FMN reductase
C4B68_RS00580	COG3415	Transposase
C4B68_RS00580	COG2801	Transposase and inactivated derivatives
C4B68_RS00625	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C4B68_RS00640	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C4B68_RS00650	COG0535	radical SAM domain protein
C4B68_RS00695	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C4B68_RS00730	COG3547	Transposase (IS116 IS110 IS902 family)
C4B68_RS00870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4B68_RS00980	COG1278	Cold shock
C4B68_RS01080	COG4221	oxidoreductase activity
C4B68_RS01100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4B68_RS01130	COG0704	Plays a role in the regulation of phosphate uptake
C4B68_RS01165	COG1024	Enoyl-CoA hydratase
C4B68_RS01170	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4B68_RS01190	COG2197	response regulator
C4B68_RS01205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4B68_RS01210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4B68_RS01260	COG2175	clavaminate synthase activity
C4B68_RS01290	COG2124	cytochrome p450
C4B68_RS01330	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4B68_RS01375	COG3328	transposase activity
C4B68_RS01455	COG1028	Short-chain dehydrogenase reductase Sdr
C4B68_RS01525	COG0596	Alpha beta hydrolase
C4B68_RS01535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4B68_RS01585	COG0515	serine threonine protein kinase
C4B68_RS01585	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4B68_RS01600	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C4B68_RS01605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C4B68_RS01630	COG1063	alcohol dehydrogenase
C4B68_RS01675	COG1404	Belongs to the peptidase S8 family
C4B68_RS01725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4B68_RS01730	COG0473	3-isopropylmalate dehydrogenase activity
C4B68_RS01730	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4B68_RS01735	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C4B68_RS01755	COG0215	cysteine-tRNA ligase activity
C4B68_RS01770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4B68_RS01775	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C4B68_RS01780	COG0492	ferredoxin-NADP+ reductase activity
C4B68_RS01785	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4B68_RS01795	COG1959	2 iron, 2 sulfur cluster binding
C4B68_RS01820	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4B68_RS01855	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4B68_RS01865	COG1073	alpha beta
C4B68_RS01870	COG1024	Enoyl-CoA hydratase
C4B68_RS01885	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C4B68_RS01890	COG3473	Maleate cis-trans isomerase
C4B68_RS02070	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C4B68_RS02075	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4B68_RS02105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4B68_RS02120	COG1846	Transcriptional regulator
C4B68_RS02175	COG1819	glycosyl
C4B68_RS02190	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4B68_RS02220	COG1136	(ABC) transporter
C4B68_RS02220	COG0577	efflux transmembrane transporter activity
C4B68_RS02225	COG1136	(ABC) transporter
C4B68_RS02245	COG0745	RESPONSE REGULATOR receiver
C4B68_RS02250	COG2205	protein histidine kinase activity
C4B68_RS02260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4B68_RS02315	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4B68_RS02380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4B68_RS02390	COG1660	Displays ATPase and GTPase activities
C4B68_RS02455	COG1720	tRNA m6t6A37 methyltransferase activity
C4B68_RS02495	COG3387	PFAM Glycoside hydrolase 15-related
C4B68_RS02500	COG2409	Drug exporters of the RND superfamily
C4B68_RS02550	COG1271	oxidase subunit
C4B68_RS02555	COG1294	oxidase, subunit
C4B68_RS02565	COG2259	Doxx family
C4B68_RS02580	COG0542	response to heat
C4B68_RS02585	COG0071	Belongs to the small heat shock protein (HSP20) family
C4B68_RS02615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4B68_RS02640	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4B68_RS02665	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C4B68_RS02670	COG0583	DNA-binding transcription factor activity
C4B68_RS02680	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C4B68_RS02690	COG0310	cobalt ion transport
C4B68_RS02695	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
C4B68_RS02700	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C4B68_RS02705	COG1122	ATPase activity
C4B68_RS02740	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C4B68_RS02745	COG0714	Associated with various cellular activities
C4B68_RS02765	COG2132	Multicopper oxidase
C4B68_RS02825	COG3852	Histidine kinase
C4B68_RS02875	COG3647	Membrane
C4B68_RS02880	COG0667	Aldo Keto reductase
C4B68_RS02905	COG2340	Cysteine-rich secretory protein family
C4B68_RS02980	COG2837	iron assimilation
C4B68_RS03005	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4B68_RS03020	COG1132	(ABC) transporter
C4B68_RS03080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4B68_RS03090	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4B68_RS03090	COG3608	succinylglutamate desuccinylase aspartoacylase
C4B68_RS03150	COG0671	phosphoesterase, PA-phosphatase related
C4B68_RS03155	COG0248	Ppx GppA phosphatase
C4B68_RS03170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4B68_RS03195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4B68_RS03235	COG0640	Transcriptional regulator
C4B68_RS03245	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C4B68_RS03265	COG2267	carboxylic ester hydrolase activity
C4B68_RS03290	COG2124	cytochrome p450
C4B68_RS03315	COG2124	cytochrome p450
C4B68_RS03345	COG2124	cytochrome p450
C4B68_RS03350	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
C4B68_RS03360	COG2223	nitrite transmembrane transporter activity
C4B68_RS03365	COG1028	Short-chain dehydrogenase reductase Sdr
C4B68_RS03370	COG0277	FAD linked oxidase domain protein
C4B68_RS03375	COG1070	Carbohydrate kinase
C4B68_RS03380	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4B68_RS03405	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4B68_RS03445	COG1796	DNA polymerase
C4B68_RS03445	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C4B68_RS03465	COG2182	Extracellular solute-binding protein
C4B68_RS03470	COG1175	transmembrane transport
C4B68_RS03475	COG0395	ABC-type sugar transport system, permease component
C4B68_RS03480	COG2723	6-phospho-beta-galactosidase activity
C4B68_RS03510	COG2706	6-phosphogluconolactonase activity
C4B68_RS03520	COG1309	transcriptional regulator
C4B68_RS03530	COG1357	PFAM Pentapeptide repeats (8 copies)
C4B68_RS03535	COG0789	Transcriptional regulator
C4B68_RS03540	COG1595	DNA-templated transcription, initiation
C4B68_RS03555	COG1609	Transcriptional regulator
C4B68_RS03570	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4B68_RS03580	COG3347	Dehydrogenase
C4B68_RS03580	COG1028	Short-chain dehydrogenase reductase Sdr
C4B68_RS03585	COG1070	Carbohydrate kinase
C4B68_RS03590	COG0247	lactate metabolic process
C4B68_RS03595	COG1139	Iron-sulfur cluster binding protein
C4B68_RS03600	COG1556	Lactate utilization protein
C4B68_RS03605	COG3408	Glycogen debranching enzyme
C4B68_RS03605	COG3408	Glycogen debranching enzyme
C4B68_RS03625	COG1174	glycine betaine transport
C4B68_RS03650	COG1404	Belongs to the peptidase S8 family
C4B68_RS03660	COG1793	dna ligase
C4B68_RS03695	COG0242	peptide deformylase activity
C4B68_RS03705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4B68_RS03715	COG1609	Transcriptional regulator
C4B68_RS03730	COG2268	Band 7 protein
C4B68_RS03750	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C4B68_RS03755	COG0121	glutamine amidotransferase
C4B68_RS03760	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
C4B68_RS03765	COG2182	Extracellular solute-binding protein
C4B68_RS03795	COG0667	Aldo Keto reductase
C4B68_RS03815	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C4B68_RS03820	COG1053	succinate dehydrogenase
C4B68_RS03830	COG0583	DNA-binding transcription factor activity
C4B68_RS03835	COG1028	Short-chain dehydrogenase reductase Sdr
C4B68_RS03875	COG0726	polysaccharide deacetylase
C4B68_RS03895	COG3507	Belongs to the glycosyl hydrolase 43 family
C4B68_RS03920	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C4B68_RS03965	COG3537	Alpha-1,2-mannosidase
C4B68_RS03980	COG1609	Transcriptional regulator
C4B68_RS03985	COG1879	ABC-type sugar transport system periplasmic component
C4B68_RS03990	COG1129	ABC transporter
C4B68_RS03995	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4B68_RS04000	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4B68_RS04005	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C4B68_RS04010	COG0297	glycogen (starch) synthase activity
C4B68_RS04035	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C4B68_RS04065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4B68_RS04065	COG1024	Enoyl-CoA hydratase
C4B68_RS04080	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C4B68_RS04085	COG0298	carbon dioxide binding
C4B68_RS04100	COG0375	protein maturation
C4B68_RS04120	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C4B68_RS04145	COG2084	Dehydrogenase
C4B68_RS04180	COG0006	proline dipeptidase activity
C4B68_RS04205	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C4B68_RS04210	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C4B68_RS04230	COG2814	Major facilitator Superfamily
C4B68_RS04240	COG1802	Transcriptional regulator
C4B68_RS04250	COG0022	dehydrogenase e1 component
C4B68_RS04255	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4B68_RS04265	COG1132	(ABC) transporter
C4B68_RS04275	COG1024	Enoyl-CoA hydratase
C4B68_RS04280	COG0668	transmembrane transport
C4B68_RS04285	COG2838	Isocitrate dehydrogenase
C4B68_RS04305	COG2867	negative regulation of translational initiation
C4B68_RS04340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4B68_RS04345	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4B68_RS04355	COG3387	PFAM Glycoside hydrolase 15-related
C4B68_RS04460	COG3239	Fatty acid desaturase
C4B68_RS04480	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C4B68_RS04485	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4B68_RS04505	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C4B68_RS04510	COG1132	(ABC) transporter
C4B68_RS04525	COG1028	Short-chain dehydrogenase reductase Sdr
C4B68_RS04530	COG1169	isochorismate synthase
C4B68_RS04535	COG1021	2,3-dihydroxybenzoate-AMP ligase
C4B68_RS04540	COG1535	isochorismatase
C4B68_RS04540	COG3433	isochorismatase activity
C4B68_RS04545	COG3433	isochorismatase activity
C4B68_RS04545	COG1535	isochorismatase
C4B68_RS04550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4B68_RS04550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4B68_RS04580	COG3345	alpha-galactosidase
C4B68_RS04585	COG0395	ABC-type sugar transport system, permease component
C4B68_RS04590	COG1175	transmembrane transport
C4B68_RS04600	COG1940	carbohydrate kinase activity
C4B68_RS04665	COG3959	Transketolase, thiamine diphosphate binding domain
C4B68_RS04670	COG3958	Transketolase
C4B68_RS04680	COG0583	DNA-binding transcription factor activity
C4B68_RS04685	COG0156	8-amino-7-oxononanoate synthase activity
C4B68_RS04690	COG1063	alcohol dehydrogenase
C4B68_RS04750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C4B68_RS04765	COG2755	lipolytic protein G-D-S-L family
C4B68_RS04770	COG2365	Tyrosine phosphatase family
C4B68_RS04790	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4B68_RS04795	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C4B68_RS04810	COG1657	PFAM Prenyltransferase squalene oxidase
C4B68_RS04820	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C4B68_RS04830	COG1562	ergosterol biosynthetic process
C4B68_RS04835	COG1134	teichoic acid transport
C4B68_RS04835	COG1388	LysM domain
C4B68_RS04880	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C4B68_RS04895	COG1024	Enoyl-CoA hydratase
C4B68_RS04905	COG4977	sequence-specific DNA binding
C4B68_RS04915	COG2183	response to ionizing radiation
C4B68_RS04920	COG0488	(ABC) transporter
C4B68_RS04940	COG2936	dipeptidyl-peptidase activity
C4B68_RS04950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4B68_RS04960	COG0789	Transcriptional regulator
C4B68_RS04965	COG1024	Enoyl-CoA hydratase
C4B68_RS04965	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4B68_RS04970	COG0183	Belongs to the thiolase family
C4B68_RS04975	COG1960	acyl-CoA dehydrogenase activity
C4B68_RS04985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4B68_RS04995	COG3268	Saccharopine dehydrogenase
C4B68_RS05000	COG1515	deoxyribonuclease V activity
C4B68_RS05030	COG0488	(ABC) transporter
C4B68_RS05035	COG1834	amidinotransferase
C4B68_RS05125	COG1793	dna ligase
C4B68_RS05135	COG1846	Transcriptional regulator
C4B68_RS05145	COG3485	protocatechuate 3,4-dioxygenase
C4B68_RS05150	COG3485	protocatechuate 3,4-dioxygenase
C4B68_RS05160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4B68_RS05195	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4B68_RS05210	COG0410	ABC transporter
C4B68_RS05220	COG0318	PFAM AMP-dependent synthetase and ligase
C4B68_RS05255	COG3485	protocatechuate 3,4-dioxygenase
C4B68_RS05275	COG0366	Alpha amylase catalytic
C4B68_RS05280	COG0395	ABC-type sugar transport system, permease component
C4B68_RS05290	COG1175	transmembrane transport
C4B68_RS05340	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4B68_RS05350	COG3469	chitinase activity
C4B68_RS05360	COG1486	melibiose metabolic process
C4B68_RS05395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4B68_RS05410	COG0166	Belongs to the GPI family
C4B68_RS05415	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C4B68_RS05420	COG0406	alpha-ribazole phosphatase activity
C4B68_RS05435	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
C4B68_RS05435	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
C4B68_RS05440	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
C4B68_RS05470	COG2226	methyltransferase
C4B68_RS05480	COG0438	transferase activity, transferring glycosyl groups
C4B68_RS05500	COG3467	pyridoxamine 5'-phosphate
C4B68_RS05520	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4B68_RS05540	COG0438	transferase activity, transferring glycosyl groups
C4B68_RS05570	COG1174	glycine betaine transport
C4B68_RS05590	COG2018	Roadblock/LC7 domain
C4B68_RS05630	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4B68_RS05635	COG0028	Belongs to the TPP enzyme family
C4B68_RS05640	COG0318	PFAM AMP-dependent synthetase and ligase
C4B68_RS05645	COG0583	DNA-binding transcription factor activity
C4B68_RS05660	COG3383	formate dehydrogenase (NAD+) activity
C4B68_RS05675	COG1802	Transcriptional regulator
C4B68_RS05690	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4B68_RS05720	COG1404	Belongs to the peptidase S8 family
C4B68_RS05745	COG0210	DNA helicase
C4B68_RS05750	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C4B68_RS05750	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C4B68_RS05820	COG0515	serine threonine protein kinase
C4B68_RS05825	COG0515	serine threonine protein kinase
C4B68_RS05845	COG3284	Transcriptional regulator
C4B68_RS05850	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C4B68_RS05870	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4B68_RS05885	COG0535	radical SAM domain protein
C4B68_RS05890	COG1971	Probably functions as a manganese efflux pump
C4B68_RS05915	COG4989	oxidoreductase activity
C4B68_RS05925	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4B68_RS05930	COG1454	alcohol dehydrogenase
C4B68_RS05940	COG1802	Transcriptional regulator
C4B68_RS05950	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4B68_RS05955	COG1129	ABC transporter
C4B68_RS05975	COG2072	flavoprotein involved in K transport
C4B68_RS05985	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C4B68_RS05995	COG0183	Belongs to the thiolase family
C4B68_RS06000	COG0583	DNA-binding transcription factor activity
C4B68_RS06025	COG3547	Transposase (IS116 IS110 IS902 family)
C4B68_RS06035	COG3012	SEC-C Motif Domain Protein
C4B68_RS06065	COG1012	belongs to the aldehyde dehydrogenase family
C4B68_RS06075	COG0045	succinate-CoA ligase (ADP-forming) activity
C4B68_RS06080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4B68_RS06090	COG2223	nitrite transmembrane transporter activity
C4B68_RS06130	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C4B68_RS06145	COG3507	Belongs to the glycosyl hydrolase 43 family
C4B68_RS06155	COG0673	inositol 2-dehydrogenase activity
C4B68_RS06160	COG1879	ABC-type sugar transport system periplasmic component
C4B68_RS06165	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4B68_RS06170	COG1129	ABC transporter
C4B68_RS06175	COG1940	carbohydrate kinase activity
C4B68_RS06185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4B68_RS06195	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4B68_RS06205	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C4B68_RS06245	COG0656	L-ascorbic acid biosynthetic process
C4B68_RS06250	COG4221	oxidoreductase activity
C4B68_RS06265	COG2226	methyltransferase
C4B68_RS06270	COG2154	pterin-4-alpha-carbinolamine dehydratase
C4B68_RS06290	COG0443	Heat shock 70 kDa protein
C4B68_RS06350	COG0693	protein deglycase activity
C4B68_RS06365	COG0488	(ABC) transporter
C4B68_RS06370	COG2226	methyltransferase
C4B68_RS06375	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C4B68_RS06385	COG0457	Tetratricopeptide repeat
C4B68_RS06395	COG1619	proteins homologs of microcin C7 resistance protein MccF
C4B68_RS06405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4B68_RS06410	COG2362	D-Aminopeptidase
C4B68_RS06425	COG2084	Dehydrogenase
C4B68_RS06440	COG2172	sigma factor antagonist activity
C4B68_RS06440	COG2208	phosphoserine phosphatase activity
C4B68_RS06440	COG1366	Belongs to the anti-sigma-factor antagonist family
C4B68_RS06480	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4B68_RS06490	COG0604	alcohol dehydrogenase
C4B68_RS06505	COG2301	Belongs to the HpcH HpaI aldolase family
C4B68_RS06515	COG1960	acyl-CoA dehydrogenase activity
C4B68_RS06520	COG0688	phosphatidylethanolamine metabolic process
C4B68_RS06540	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4B68_RS06560	COG1929	Belongs to the glycerate kinase type-1 family
C4B68_RS06575	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C4B68_RS06600	COG0640	Transcriptional regulator
C4B68_RS06630	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C4B68_RS06640	COG0483	inositol monophosphate 1-phosphatase activity
C4B68_RS06650	COG0765	amino acid transport
C4B68_RS06655	COG0765	amino acid transport
C4B68_RS06660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4B68_RS06665	COG1126	abc transporter atp-binding protein
C4B68_RS06695	COG2197	response regulator
C4B68_RS06705	COG1953	Uracil, thiamine, allantoin
C4B68_RS06715	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4B68_RS06740	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4B68_RS06765	COG0405	Gamma-glutamyltransferase
C4B68_RS06775	COG1376	ErfK ybiS ycfS ynhG family protein
C4B68_RS06820	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4B68_RS06830	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4B68_RS06865	COG0181	hydroxymethylbilane synthase activity
C4B68_RS06875	COG0494	nUDIX hydrolase
C4B68_RS06935	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4B68_RS06965	COG0242	peptide deformylase activity
C4B68_RS07005	COG2771	luxR family
C4B68_RS07010	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4B68_RS07040	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4B68_RS07070	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4B68_RS07140	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C4B68_RS07230	COG0494	nUDIX hydrolase
C4B68_RS07260	COG0494	nUDIX hydrolase
C4B68_RS07285	COG0154	amidase activity
C4B68_RS07440	COG0587	DNA-directed DNA polymerase activity
C4B68_RS07485	COG0641	radical SAM
C4B68_RS07520	COG2223	nitrite transmembrane transporter activity
C4B68_RS07525	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4B68_RS07895	COG1733	regulation of RNA biosynthetic process
C4B68_RS07945	COG1201	RNA secondary structure unwinding
C4B68_RS07970	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4B68_RS08020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4B68_RS08035	COG2326	polyphosphate kinase activity
C4B68_RS08050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4B68_RS08060	COG1940	carbohydrate kinase activity
C4B68_RS08080	COG2188	Transcriptional regulator
C4B68_RS08085	COG0673	inositol 2-dehydrogenase activity
C4B68_RS08100	COG4266	Belongs to the allantoicase family
C4B68_RS08110	COG1414	Transcriptional regulator
C4B68_RS08120	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4B68_RS08125	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C4B68_RS08205	COG4264	IucA IucC family
C4B68_RS08230	COG0436	Aminotransferase
C4B68_RS08250	COG0406	alpha-ribazole phosphatase activity
C4B68_RS08280	COG2351	hydroxyisourate hydrolase activity
C4B68_RS08315	COG3622	Belongs to the hyi family
C4B68_RS08320	COG2084	Dehydrogenase
C4B68_RS08330	COG3960	tartronate-semialdehyde synthase activity
C4B68_RS08340	COG0318	PFAM AMP-dependent synthetase and ligase
C4B68_RS08345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4B68_RS08350	COG2197	response regulator
C4B68_RS08390	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4B68_RS08430	COG3510	cephalosporin hydroxylase
C4B68_RS08435	COG2124	cytochrome p450
C4B68_RS08440	COG0318	PFAM AMP-dependent synthetase and ligase
C4B68_RS08445	COG1960	acyl-CoA dehydrogenase activity
C4B68_RS08460	COG0604	alcohol dehydrogenase
C4B68_RS08460	COG3321	synthase
C4B68_RS08470	COG4221	oxidoreductase activity
C4B68_RS08475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4B68_RS08485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4B68_RS08490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4B68_RS08505	COG1028	Short-chain dehydrogenase reductase Sdr
C4B68_RS08520	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4B68_RS08520	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4B68_RS08525	COG1846	Transcriptional regulator
C4B68_RS08550	COG2409	Drug exporters of the RND superfamily
C4B68_RS08565	COG3629	intracellular signal transduction
C4B68_RS08565	COG3903	Transcriptional regulator
C4B68_RS08575	COG2084	Dehydrogenase
C4B68_RS08580	COG3395	kinase activity
C4B68_RS08585	COG0235	Class ii aldolase
C4B68_RS08590	COG2271	Major facilitator Superfamily
C4B68_RS08595	COG3622	Belongs to the hyi family
C4B68_RS08600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4B68_RS08605	COG2186	Transcriptional regulator
C4B68_RS08620	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4B68_RS08635	COG3835	regulator
C4B68_RS08675	COG1802	Transcriptional regulator
C4B68_RS08740	COG1162	GTPase activity
C4B68_RS08755	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C4B68_RS08770	COG1404	Belongs to the peptidase S8 family
C4B68_RS08795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4B68_RS08815	COG0277	FAD linked oxidase domain protein
C4B68_RS08885	COG2264	protein methyltransferase activity
C4B68_RS08890	COG2040	homocysteine
C4B68_RS08935	COG1960	acyl-CoA dehydrogenase activity
C4B68_RS08995	COG0175	sulfate reduction
C4B68_RS09000	COG0529	Catalyzes the synthesis of activated sulfate
C4B68_RS09025	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4B68_RS09030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4B68_RS09040	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C4B68_RS09055	COG2409	Drug exporters of the RND superfamily
C4B68_RS09140	COG3173	Aminoglycoside phosphotransferase
C4B68_RS09150	COG1280	lysine exporter protein (LysE YggA)
C4B68_RS09155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4B68_RS09190	COG1674	ftsk spoiiie
C4B68_RS09215	COG0673	inositol 2-dehydrogenase activity
C4B68_RS09240	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4B68_RS09245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4B68_RS09300	COG3220	belongs to the UPF0276 family
C4B68_RS09315	COG3253	May function as heme-dependent peroxidase
C4B68_RS09320	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C4B68_RS09330	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4B68_RS09345	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C4B68_RS09360	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C4B68_RS09365	COG0183	Belongs to the thiolase family
C4B68_RS09370	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4B68_RS09370	COG1024	Enoyl-CoA hydratase
C4B68_RS09390	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4B68_RS09415	COG0531	amino acid
C4B68_RS09420	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4B68_RS09425	COG4214	carbohydrate transport
C4B68_RS09435	COG4213	ABC transporter substrate-binding protein
C4B68_RS09440	COG1940	carbohydrate kinase activity
C4B68_RS09445	COG0395	ABC-type sugar transport system, permease component
C4B68_RS09450	COG1175	transmembrane transport
C4B68_RS09455	COG1653	transport
C4B68_RS09465	COG3290	protein histidine kinase activity
C4B68_RS09470	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4B68_RS09475	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C4B68_RS09480	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4B68_RS09540	COG1201	RNA secondary structure unwinding
C4B68_RS09555	COG0745	RESPONSE REGULATOR receiver
C4B68_RS09560	COG1902	pentaerythritol trinitrate reductase activity
C4B68_RS09600	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4B68_RS09620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4B68_RS09695	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4B68_RS09735	COG1024	Enoyl-CoA hydratase
C4B68_RS09750	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4B68_RS09755	COG2235	arginine
C4B68_RS09775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4B68_RS09795	COG1799	cell septum assembly
C4B68_RS09830	COG1960	acyl-CoA dehydrogenase activity
C4B68_RS09845	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4B68_RS09880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4B68_RS09885	COG0531	amino acid
C4B68_RS09890	COG0569	domain protein
C4B68_RS09925	COG0756	dUTP diphosphatase activity
C4B68_RS09950	COG2205	protein histidine kinase activity
C4B68_RS09955	COG0745	RESPONSE REGULATOR receiver
C4B68_RS09960	COG0483	inositol monophosphate 1-phosphatase activity
C4B68_RS09965	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C4B68_RS10005	COG1435	thymidine kinase activity
C4B68_RS10010	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4B68_RS10025	COG1435	thymidine kinase activity
C4B68_RS10040	COG0045	succinate-CoA ligase (ADP-forming) activity
C4B68_RS10040	COG1042	CoA-binding domain protein
C4B68_RS10040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4B68_RS10050	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4B68_RS10055	COG1802	Transcriptional regulator
C4B68_RS10060	COG0739	heme binding
C4B68_RS10070	COG0612	Peptidase, M16
C4B68_RS10075	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C4B68_RS10100	COG3290	protein histidine kinase activity
C4B68_RS10105	COG4565	transcriptional regulatory protein
C4B68_RS10110	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4B68_RS10120	COG0187	DNA topoisomerase II activity
C4B68_RS10135	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4B68_RS10140	COG2186	Transcriptional regulator
C4B68_RS10180	COG1362	aminopeptidase activity
C4B68_RS10190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4B68_RS10200	COG0514	ATP-dependent DNA helicase (RecQ)
C4B68_RS10215	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4B68_RS10260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4B68_RS10265	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4B68_RS10270	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4B68_RS10305	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4B68_RS10315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4B68_RS10320	COG1012	belongs to the aldehyde dehydrogenase family
C4B68_RS10330	COG1028	Short-chain dehydrogenase reductase Sdr
C4B68_RS10345	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4B68_RS10355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4B68_RS10360	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4B68_RS10370	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4B68_RS10395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4B68_RS10405	COG2358	TRAP transporter, solute receptor (TAXI family
C4B68_RS10410	COG2205	protein histidine kinase activity
C4B68_RS10415	COG0745	RESPONSE REGULATOR receiver
C4B68_RS10420	COG1126	abc transporter atp-binding protein
C4B68_RS10425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4B68_RS10430	COG0765	amino acid transport
C4B68_RS10435	COG0765	amino acid transport
C4B68_RS10440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4B68_RS10460	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4B68_RS10470	COG0628	permease
C4B68_RS10500	COG1201	RNA secondary structure unwinding
C4B68_RS10505	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C4B68_RS10510	COG1028	Short-chain dehydrogenase reductase Sdr
C4B68_RS10520	COG0783	Belongs to the Dps family
C4B68_RS10525	COG1396	sequence-specific DNA binding
C4B68_RS10530	COG1058	Belongs to the CinA family
C4B68_RS10530	COG1546	Belongs to the CinA family
C4B68_RS10540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4B68_RS10550	COG1674	ftsk spoiiie
C4B68_RS10560	COG2205	protein histidine kinase activity
C4B68_RS10560	COG3850	Histidine kinase
C4B68_RS10560	COG3437	response regulator, receiver
C4B68_RS10560	COG4999	Histidine kinase
C4B68_RS10570	COG2770	Histidine kinase
C4B68_RS10570	COG2208	phosphoserine phosphatase activity
C4B68_RS10580	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4B68_RS10605	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C4B68_RS10610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4B68_RS10615	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C4B68_RS10635	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C4B68_RS10640	COG0612	Peptidase, M16
C4B68_RS10645	COG1185	polyribonucleotide nucleotidyltransferase activity
C4B68_RS10650	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C4B68_RS10665	COG1674	ftsk spoiiie
C4B68_RS10730	COG1404	Belongs to the peptidase S8 family
C4B68_RS10770	COG0455	bacterial-type flagellum organization
C4B68_RS10780	COG0601	transmembrane transport
C4B68_RS10785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4B68_RS10810	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C4B68_RS10815	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C4B68_RS10825	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4B68_RS10840	COG0779	Required for maturation of 30S ribosomal subunits
C4B68_RS10860	COG0442	prolyl-tRNA aminoacylation
C4B68_RS10875	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C4B68_RS10880	COG0750	zinc metalloprotease
C4B68_RS10885	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C4B68_RS10890	COG0653	protein targeting
C4B68_RS10910	COG1012	belongs to the aldehyde dehydrogenase family
C4B68_RS10920	COG2508	Transcriptional regulator
C4B68_RS10920	COG2508	Transcriptional regulator
C4B68_RS10965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4B68_RS10970	COG1177	transmembrane transport
C4B68_RS10975	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4B68_RS10980	COG3842	ATPase activity
C4B68_RS11005	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4B68_RS11010	COG0584	glycerophosphoryl diester phosphodiesterase
C4B68_RS11020	COG1733	regulation of RNA biosynthetic process
C4B68_RS11030	COG1012	belongs to the aldehyde dehydrogenase family
C4B68_RS11040	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C4B68_RS11045	COG1136	(ABC) transporter
C4B68_RS11075	COG3842	ATPase activity
C4B68_RS11080	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C4B68_RS11090	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4B68_RS11095	COG0575	Belongs to the CDS family
C4B68_RS11100	COG0233	cytoplasmic translational termination
C4B68_RS11105	COG0528	UMP kinase activity
C4B68_RS11110	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C4B68_RS11115	COG0052	Belongs to the universal ribosomal protein uS2 family
C4B68_RS11130	COG1191	sigma factor activity
C4B68_RS11145	COG0792	nuclease activity
C4B68_RS11155	COG0789	Transcriptional regulator
C4B68_RS11190	COG0681	Belongs to the peptidase S26 family
C4B68_RS11205	COG0335	large ribosomal subunit rRNA binding
C4B68_RS11210	COG0336	Belongs to the RNA methyltransferase TrmD family
C4B68_RS11215	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C4B68_RS11220	COG1837	Belongs to the UPF0109 family
C4B68_RS11225	COG0228	four-way junction DNA binding
C4B68_RS11235	COG0442	prolyl-tRNA aminoacylation
C4B68_RS11245	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4B68_RS11255	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C4B68_RS11300	COG1196	nuclear chromosome segregation
C4B68_RS11315	COG1254	Belongs to the acylphosphatase family
C4B68_RS11320	COG2340	Cysteine-rich secretory protein family
C4B68_RS11325	COG1733	regulation of RNA biosynthetic process
C4B68_RS11330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C4B68_RS11335	COG0571	ribonuclease III activity
C4B68_RS11340	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C4B68_RS11355	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C4B68_RS11360	COG0742	ribosomal rna small subunit methyltransferase
C4B68_RS11370	COG0326	Molecular chaperone. Has ATPase activity
C4B68_RS11385	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4B68_RS11390	COG0351	phosphomethylpyrimidine kinase
C4B68_RS11410	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4B68_RS11415	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4B68_RS11425	COG1920	GTP binding
C4B68_RS11440	COG0776	regulation of translation
C4B68_RS11450	COG0066	3-isopropylmalate dehydratase activity
C4B68_RS11455	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4B68_RS11460	COG1414	Transcriptional regulator
C4B68_RS11505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4B68_RS11510	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4B68_RS11520	COG5002	protein histidine kinase activity
C4B68_RS11525	COG2018	Roadblock/LC7 domain
C4B68_RS11550	COG2018	Roadblock/LC7 domain
C4B68_RS11570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4B68_RS11580	COG2353	YceI-like domain
C4B68_RS11610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4B68_RS11615	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4B68_RS11620	COG0473	3-isopropylmalate dehydrogenase activity
C4B68_RS11640	COG1012	belongs to the aldehyde dehydrogenase family
C4B68_RS11645	COG0506	proline dehydrogenase activity
C4B68_RS11660	COG2197	response regulator
C4B68_RS11670	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C4B68_RS11675	COG0440	acetolactate synthase activity
C4B68_RS11685	COG5001	Diguanylate cyclase
C4B68_RS11695	COG0667	Aldo Keto reductase
C4B68_RS11700	COG2133	pyrroloquinoline quinone binding
C4B68_RS11710	COG1672	PFAM Archaeal ATPase
C4B68_RS11710	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C4B68_RS11725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4B68_RS11730	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4B68_RS11740	COG0154	amidase activity
C4B68_RS11745	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4B68_RS11755	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4B68_RS11765	COG4221	oxidoreductase activity
C4B68_RS11770	COG1611	Belongs to the LOG family
C4B68_RS11780	COG0482	sulfurtransferase activity
C4B68_RS11820	COG2860	membrane
C4B68_RS11825	COG4608	Belongs to the ABC transporter superfamily
C4B68_RS11830	COG0444	Belongs to the ABC transporter superfamily
C4B68_RS11835	COG0601	transmembrane transport
C4B68_RS11840	COG0747	negative chemotaxis
C4B68_RS11845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4B68_RS11865	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4B68_RS11870	COG0509	glycine decarboxylation via glycine cleavage system
C4B68_RS11875	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4B68_RS11880	COG1760	l-serine dehydratase
C4B68_RS11890	COG0277	FAD linked oxidase domain protein
C4B68_RS11895	COG0318	PFAM AMP-dependent synthetase and ligase
C4B68_RS11895	COG0204	Acyl-transferase
C4B68_RS11900	COG4221	oxidoreductase activity
C4B68_RS11930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4B68_RS11940	COG0789	Transcriptional regulator
C4B68_RS11980	COG1376	ErfK ybiS ycfS ynhG family protein
C4B68_RS11995	COG1132	(ABC) transporter
C4B68_RS12000	COG1132	(ABC) transporter
C4B68_RS12035	COG2154	pterin-4-alpha-carbinolamine dehydratase
C4B68_RS12090	COG0058	SHG alpha-glucan phosphorylase activity
C4B68_RS12100	COG0366	Alpha amylase catalytic
C4B68_RS12110	COG3281	Trehalose synthase
C4B68_RS12115	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4B68_RS12125	COG3118	belongs to the thioredoxin family
C4B68_RS12140	COG0477	Major facilitator Superfamily
C4B68_RS12150	COG1301	dicarboxylic acid transport
C4B68_RS12155	COG3290	protein histidine kinase activity
C4B68_RS12170	COG1175	transmembrane transport
C4B68_RS12175	COG0395	ABC-type sugar transport system, permease component
C4B68_RS12185	COG0205	6-phosphofructokinase activity
C4B68_RS12190	COG0857	belongs to the CobB CobQ family
C4B68_RS12190	COG0280	phosphate acetyltransferase
C4B68_RS12195	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C4B68_RS12240	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4B68_RS12240	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4B68_RS12300	COG0183	Belongs to the thiolase family
C4B68_RS12320	COG1131	(ABC) transporter
C4B68_RS12365	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
C4B68_RS12380	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4B68_RS12430	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C4B68_RS12435	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C4B68_RS12440	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C4B68_RS12445	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C4B68_RS12450	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4B68_RS12455	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C4B68_RS12460	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4B68_RS12475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4B68_RS12480	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4B68_RS12485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4B68_RS12495	COG2890	protein-(glutamine-N5) methyltransferase activity
C4B68_RS12500	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4B68_RS12505	COG0254	rRNA binding
C4B68_RS12525	COG0083	homoserine kinase activity
C4B68_RS12530	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C4B68_RS12535	COG0460	homoserine dehydrogenase
C4B68_RS12540	COG0019	diaminopimelate decarboxylase activity
C4B68_RS12545	COG0018	arginyl-trna synthetase
C4B68_RS12575	COG0251	oxidation-reduction process
C4B68_RS12590	COG2188	Transcriptional regulator
C4B68_RS12675	COG2072	flavoprotein involved in K transport
C4B68_RS12685	COG0640	Transcriptional regulator
C4B68_RS12705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4B68_RS12720	COG0202	RNA polymerase activity
C4B68_RS12760	COG0583	DNA-binding transcription factor activity
C4B68_RS12830	COG1881	PFAM PEBP family protein
C4B68_RS12835	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C4B68_RS12835	COG1796	DNA polymerase
C4B68_RS12840	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C4B68_RS12845	COG3285	dna ligase
C4B68_RS12845	COG1793	dna ligase
C4B68_RS12865	COG0772	Belongs to the SEDS family
C4B68_RS12870	COG0768	penicillin binding
C4B68_RS12895	COG0791	NLP P60 protein
C4B68_RS12895	COG3883	PFAM NLP P60 protein
C4B68_RS12920	COG5002	protein histidine kinase activity
C4B68_RS12940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4B68_RS12955	COG0745	RESPONSE REGULATOR receiver
C4B68_RS12960	COG2205	protein histidine kinase activity
C4B68_RS12965	COG0567	Dehydrogenase, E1 component
C4B68_RS12965	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4B68_RS12980	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
C4B68_RS12980	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
C4B68_RS13065	COG0604	alcohol dehydrogenase
C4B68_RS13070	COG0281	malic enzyme
C4B68_RS13085	COG0765	amino acid transport
C4B68_RS13090	COG1126	abc transporter atp-binding protein
C4B68_RS13105	COG4106	trans-aconitate 2-methyltransferase activity
C4B68_RS13125	COG0582	viral genome integration into host DNA
C4B68_RS13205	COG0137	argininosuccinate synthase activity
C4B68_RS13230	COG4941	Belongs to the sigma-70 factor family
C4B68_RS13260	COG0142	geranyltranstransferase activity
C4B68_RS13265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4B68_RS13315	COG1597	lipid kinase activity
C4B68_RS13330	COG0363	glucosamine-6-phosphate deaminase activity
C4B68_RS13335	COG1472	Belongs to the glycosyl hydrolase 3 family
C4B68_RS13340	COG0395	ABC-type sugar transport system, permease component
C4B68_RS13345	COG1175	transmembrane transport
C4B68_RS13350	COG2182	Extracellular solute-binding protein
C4B68_RS13355	COG2188	Transcriptional regulator
C4B68_RS13360	COG1966	Carbon starvation protein
C4B68_RS13380	COG2337	Toxic component of a toxin-antitoxin (TA) module
C4B68_RS13405	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4B68_RS13425	COG2124	cytochrome p450
C4B68_RS13435	COG0242	peptide deformylase activity
C4B68_RS13450	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C4B68_RS13450	COG2199	diguanylate cyclase activity
C4B68_RS13455	COG5662	AntiSigma factor
C4B68_RS13460	COG1595	DNA-templated transcription, initiation
C4B68_RS13470	COG2135	peptidase activity
C4B68_RS13480	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4B68_RS13485	COG1162	GTPase activity
C4B68_RS13490	COG2076	Multidrug Resistance protein
C4B68_RS13505	COG0483	inositol monophosphate 1-phosphatase activity
C4B68_RS13515	COG0753	catalase activity
C4B68_RS13540	COG1615	UPF0182 protein
C4B68_RS13550	COG3480	Lon protease (S16) C-terminal proteolytic domain
C4B68_RS13605	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4B68_RS13660	COG0210	DNA helicase
C4B68_RS13680	COG0596	Alpha beta hydrolase
C4B68_RS13685	COG0596	Alpha beta hydrolase
C4B68_RS13770	COG1432	Conserved Protein
C4B68_RS13775	COG2095	MarC family integral membrane protein
C4B68_RS13795	COG0598	Magnesium transport protein CorA
C4B68_RS13830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4B68_RS13835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4B68_RS13845	COG1595	DNA-templated transcription, initiation
C4B68_RS13860	COG1024	Enoyl-CoA hydratase
C4B68_RS13865	COG2818	Glycosylase
C4B68_RS13875	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C4B68_RS13885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4B68_RS13935	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C4B68_RS13965	COG2319	Wd-40 repeat
C4B68_RS13965	COG4249	Peptidase C14 caspase catalytic subunit p20
C4B68_RS13985	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C4B68_RS13995	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
C4B68_RS14010	COG4608	Belongs to the ABC transporter superfamily
C4B68_RS14015	COG0444	Belongs to the ABC transporter superfamily
C4B68_RS14020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4B68_RS14025	COG0601	transmembrane transport
C4B68_RS14035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4B68_RS14040	COG0747	negative chemotaxis
C4B68_RS14045	COG0601	transmembrane transport
C4B68_RS14050	COG0444	Belongs to the ABC transporter superfamily
C4B68_RS14055	COG4608	Belongs to the ABC transporter superfamily
C4B68_RS14085	COG2318	DinB family
C4B68_RS14090	COG2226	methyltransferase
C4B68_RS14095	COG4608	Belongs to the ABC transporter superfamily
C4B68_RS14100	COG0444	Belongs to the ABC transporter superfamily
C4B68_RS14110	COG4166	transmembrane transport
C4B68_RS14115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4B68_RS14120	COG1217	gtp-binding protein TYPA
C4B68_RS14140	COG1053	succinate dehydrogenase
C4B68_RS14145	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C4B68_RS14240	COG0012	GTP binding
C4B68_RS14255	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4B68_RS14260	COG1570	exodeoxyribonuclease VII activity
C4B68_RS14265	COG1722	exodeoxyribonuclease VII activity
C4B68_RS14270	COG0778	Nitroreductase
C4B68_RS14295	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C4B68_RS14295	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C4B68_RS14300	COG0114	fumarate hydratase activity
C4B68_RS14305	COG3557	Belongs to the UPF0374 family
C4B68_RS14315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4B68_RS14315	COG4499	WXG100 protein secretion system (Wss), protein YukC
C4B68_RS14325	COG1136	(ABC) transporter
C4B68_RS14340	COG0450	alkyl hydroperoxide reductase
C4B68_RS14345	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4B68_RS14360	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C4B68_RS14365	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4B68_RS14370	COG0667	Aldo Keto reductase
C4B68_RS14375	COG2318	DinB family
C4B68_RS14385	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C4B68_RS14395	COG4115	mRNA cleavage
C4B68_RS14400	COG2885	chlorophyll binding
C4B68_RS14420	COG2197	response regulator
C4B68_RS14450	COG2894	cell division
C4B68_RS14500	COG0251	oxidation-reduction process
C4B68_RS14520	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C4B68_RS14535	COG0436	Aminotransferase
C4B68_RS14590	COG0463	Glycosyl transferase, family 2
C4B68_RS14650	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C4B68_RS14660	COG1309	transcriptional regulator
C4B68_RS14690	COG1331	Highly conserved protein containing a thioredoxin domain
C4B68_RS14705	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C4B68_RS14715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4B68_RS14730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4B68_RS14735	COG2255	four-way junction helicase activity
C4B68_RS14740	COG1595	DNA-templated transcription, initiation
C4B68_RS14760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4B68_RS14770	COG1064	alcohol dehydrogenase
C4B68_RS14780	COG1404	Belongs to the peptidase S8 family
C4B68_RS14785	COG1136	(ABC) transporter
C4B68_RS14795	COG1376	ErfK ybiS ycfS ynhG family protein
C4B68_RS14820	COG1278	Cold shock
C4B68_RS14825	COG2986	histidine ammonia-lyase
C4B68_RS14835	COG1024	Enoyl-CoA hydratase
C4B68_RS14845	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C4B68_RS14855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4B68_RS14875	COG0424	maF-like protein
C4B68_RS14885	COG4770	biotin carboxylase activity
C4B68_RS14920	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4B68_RS14940	COG1012	belongs to the aldehyde dehydrogenase family
C4B68_RS14945	COG1012	belongs to the aldehyde dehydrogenase family
C4B68_RS14965	COG1595	DNA-templated transcription, initiation
C4B68_RS14970	COG0745	RESPONSE REGULATOR receiver
C4B68_RS14975	COG2205	protein histidine kinase activity
C4B68_RS15000	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4B68_RS15010	COG0583	DNA-binding transcription factor activity
C4B68_RS15015	COG2814	Major facilitator Superfamily
C4B68_RS15040	COG1079	Belongs to the binding-protein-dependent transport system permease family
C4B68_RS15050	COG3845	ABC transporter
C4B68_RS15055	COG1744	ABC transporter substrate-binding protein PnrA-like
C4B68_RS15060	COG1744	ABC transporter substrate-binding protein PnrA-like
C4B68_RS15065	COG1473	amidohydrolase
C4B68_RS15065	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C4B68_RS15075	COG2089	acid synthase
C4B68_RS15090	COG1216	Glycosyl transferase, family 2
C4B68_RS15100	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4B68_RS15120	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4B68_RS15120	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4B68_RS15135	COG1595	DNA-templated transcription, initiation
C4B68_RS15145	COG1595	DNA-templated transcription, initiation
C4B68_RS15245	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C4B68_RS15255	COG2009	succinate dehydrogenase
C4B68_RS15265	COG1053	succinate dehydrogenase
C4B68_RS15345	COG1309	transcriptional regulator
C4B68_RS15355	COG2409	Drug exporters of the RND superfamily
C4B68_RS15360	COG0745	RESPONSE REGULATOR receiver
C4B68_RS15365	COG2205	protein histidine kinase activity
C4B68_RS15375	COG1408	metallophosphoesterase
C4B68_RS15385	COG1686	Belongs to the peptidase S11 family
C4B68_RS15390	COG1295	ribonuclease BN
C4B68_RS15425	COG0180	Tryptophanyl-tRNA synthetase
C4B68_RS15450	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4B68_RS15455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4B68_RS15460	COG0754	glutathionylspermidine amidase activity
C4B68_RS15470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4B68_RS15475	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4B68_RS15485	COG4176	ABC-type proline glycine betaine transport system permease component
C4B68_RS15490	COG0517	IMP dehydrogenase activity
C4B68_RS15490	COG4175	Glycine betaine
C4B68_RS15500	COG1012	belongs to the aldehyde dehydrogenase family
C4B68_RS15520	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C4B68_RS15520	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C4B68_RS15530	COG0039	L-malate dehydrogenase activity
C4B68_RS15545	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4B68_RS15555	COG0138	bifunctional purine biosynthesis protein purh
C4B68_RS15585	COG0045	succinate-CoA ligase (ADP-forming) activity
C4B68_RS15600	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C4B68_RS15605	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C4B68_RS15610	COG0714	Associated with various cellular activities
C4B68_RS15625	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4B68_RS15625	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4B68_RS15635	COG0739	heme binding
C4B68_RS15665	COG0791	NLP P60 protein
C4B68_RS15675	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C4B68_RS15715	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C4B68_RS15730	COG2197	response regulator
C4B68_RS15775	COG0519	Catalyzes the synthesis of GMP from XMP
C4B68_RS15775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4B68_RS15800	COG1012	belongs to the aldehyde dehydrogenase family
C4B68_RS15840	COG0515	serine threonine protein kinase
C4B68_RS15845	COG0515	serine threonine protein kinase
C4B68_RS15845	COG2815	serine threonine protein kinase
C4B68_RS15850	COG0515	serine threonine protein kinase
C4B68_RS15870	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C4B68_RS15885	COG0516	GMP reductase activity
C4B68_RS15895	COG1595	DNA-templated transcription, initiation
C4B68_RS15920	COG4221	oxidoreductase activity
C4B68_RS15930	COG0459	protein refolding
C4B68_RS15935	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C4B68_RS15940	COG0726	polysaccharide deacetylase
C4B68_RS15945	COG0726	polysaccharide deacetylase
C4B68_RS15955	COG4941	Belongs to the sigma-70 factor family
C4B68_RS15975	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C4B68_RS15995	COG0802	atpase or kinase
C4B68_RS16005	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4B68_RS16015	COG0736	holo-[acyl-carrier-protein] synthase activity
C4B68_RS16025	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4B68_RS16030	COG1072	(Pantothenic acid kinase))
C4B68_RS16040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4B68_RS16045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C4B68_RS16050	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C4B68_RS16085	COG0101	tRNA pseudouridine synthase activity
C4B68_RS16090	COG0203	ribosomal protein L17
C4B68_RS16095	COG0202	RNA polymerase activity
C4B68_RS16100	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4B68_RS16105	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4B68_RS16110	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C4B68_RS16115	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4B68_RS16125	COG0563	adenylate kinase activity
C4B68_RS16135	COG0200	Binds to the 23S rRNA
C4B68_RS16140	COG1841	ribosomal large subunit assembly
C4B68_RS16145	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4B68_RS16150	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C4B68_RS16155	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C4B68_RS16160	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C4B68_RS16170	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4B68_RS16175	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4B68_RS16180	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C4B68_RS16185	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C4B68_RS16190	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C4B68_RS16195	COG0255	Belongs to the universal ribosomal protein uL29 family
C4B68_RS16200	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C4B68_RS16205	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C4B68_RS16210	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C4B68_RS16215	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4B68_RS16220	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4B68_RS16225	COG0089	rRNA binding
C4B68_RS16230	COG0088	Forms part of the polypeptide exit tunnel
C4B68_RS16235	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C4B68_RS16240	COG0051	transcription antitermination factor activity, RNA binding
C4B68_RS16280	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4B68_RS16285	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4B68_RS16290	COG0049	tRNA binding
C4B68_RS16295	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C4B68_RS16300	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C4B68_RS16305	COG0085	RNA polymerase activity
C4B68_RS16315	COG0222	ribosome binding
C4B68_RS16320	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C4B68_RS16330	COG0081	regulation of translation
C4B68_RS16355	COG0436	Aminotransferase
C4B68_RS16360	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4B68_RS16375	COG0702	epimerase
C4B68_RS16380	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4B68_RS16390	COG2030	dehydratase
C4B68_RS16395	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4B68_RS16410	COG0402	S-adenosylhomocysteine deaminase activity
C4B68_RS16420	COG0702	epimerase
C4B68_RS16435	COG1666	GTP binding
C4B68_RS16440	COG2261	transglycosylase associated protein
C4B68_RS16460	COG3304	Inner membrane component domain
C4B68_RS16465	COG0501	Belongs to the peptidase M48B family
C4B68_RS16470	COG1007	ATP synthesis coupled electron transport
C4B68_RS16480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4B68_RS16485	COG0713	ATP synthesis coupled electron transport
C4B68_RS16490	COG0839	Belongs to the complex I subunit 6 family
C4B68_RS16495	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4B68_RS16500	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C4B68_RS16505	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4B68_RS16510	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4B68_RS16515	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4B68_RS16535	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C4B68_RS16535	COG0674	pyruvate-flavodoxin oxidoreductase activity
C4B68_RS16540	COG1013	pyruvate-flavodoxin oxidoreductase activity
C4B68_RS16545	COG1733	regulation of RNA biosynthetic process
C4B68_RS16550	COG0702	epimerase
C4B68_RS16565	COG1733	regulation of RNA biosynthetic process
C4B68_RS16595	COG0741	lytic transglycosylase activity
C4B68_RS16595	COG0739	heme binding
C4B68_RS16595	COG1196	nuclear chromosome segregation
C4B68_RS16650	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4B68_RS16670	COG1131	(ABC) transporter
C4B68_RS16685	COG0142	geranyltranstransferase activity
C4B68_RS16700	COG0561	phosphatase activity
C4B68_RS16720	COG0514	ATP-dependent DNA helicase (RecQ)
C4B68_RS16725	COG1007	ATP synthesis coupled electron transport
C4B68_RS16735	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4B68_RS16740	COG0713	ATP synthesis coupled electron transport
C4B68_RS16750	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4B68_RS16755	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C4B68_RS16760	COG1034	ATP synthesis coupled electron transport
C4B68_RS16765	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C4B68_RS16775	COG0649	NAD binding
C4B68_RS16780	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4B68_RS16785	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4B68_RS16795	COG3103	Sh3 type 3 domain protein
C4B68_RS16795	COG1388	LysM domain
C4B68_RS16795	COG0791	NLP P60 protein
C4B68_RS16800	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
C4B68_RS16800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4B68_RS16805	COG0242	peptide deformylase activity
C4B68_RS16825	COG2226	methyltransferase
C4B68_RS16835	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C4B68_RS16845	COG0584	glycerophosphoryl diester phosphodiesterase
C4B68_RS16900	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
C4B68_RS16940	COG0431	NADPH-dependent FMN reductase
C4B68_RS16990	COG1674	ftsk spoiiie
C4B68_RS17000	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C4B68_RS17005	COG1278	Cold shock
C4B68_RS17015	COG2124	cytochrome p450
C4B68_RS17050	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C4B68_RS17060	COG0163	prenyltransferase activity
C4B68_RS17065	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C4B68_RS17070	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C4B68_RS17120	COG0640	Transcriptional regulator
C4B68_RS17125	COG0346	lactoylglutathione lyase activity
C4B68_RS17155	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C4B68_RS17160	COG1333	cytochrome c biogenesis protein
C4B68_RS17165	COG0785	Cytochrome C biogenesis protein
C4B68_RS17170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4B68_RS17180	COG0406	alpha-ribazole phosphatase activity
C4B68_RS17185	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4B68_RS17230	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C4B68_RS17235	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C4B68_RS17240	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C4B68_RS17265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4B68_RS17280	COG1846	Transcriptional regulator
C4B68_RS17290	COG1742	UPF0060 membrane protein
C4B68_RS17300	COG1690	Belongs to the RtcB family
C4B68_RS17320	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
C4B68_RS17325	COG0018	arginyl-trna synthetase
C4B68_RS17335	COG0113	porphobilinogen synthase activity
C4B68_RS17350	COG0583	DNA-binding transcription factor activity
C4B68_RS17370	COG1309	transcriptional regulator
C4B68_RS17385	COG0475	glutathione-regulated potassium exporter activity
C4B68_RS17385	COG0569	domain protein
C4B68_RS17395	COG1648	precorrin-2 dehydrogenase activity
C4B68_RS17395	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4B68_RS17400	COG0181	hydroxymethylbilane synthase activity
C4B68_RS17405	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C4B68_RS17410	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C4B68_RS17465	COG0123	including yeast histone deacetylase and acetoin utilization protein
C4B68_RS17475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4B68_RS17500	COG0180	Tryptophanyl-tRNA synthetase
C4B68_RS17505	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C4B68_RS17515	COG1129	ABC transporter
C4B68_RS17515	COG0842	Transport permease protein
C4B68_RS17535	COG4991	sh3 domain protein
C4B68_RS17540	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4B68_RS17540	COG0515	serine threonine protein kinase
C4B68_RS17545	COG0129	dihydroxy-acid dehydratase activity
C4B68_RS17550	COG1309	transcriptional regulator
C4B68_RS17555	COG1082	Xylose isomerase domain protein TIM barrel
C4B68_RS17560	COG0248	Ppx GppA phosphatase
C4B68_RS17585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C4B68_RS17600	COG1595	DNA-templated transcription, initiation
C4B68_RS17610	COG0745	RESPONSE REGULATOR receiver
C4B68_RS17615	COG2205	protein histidine kinase activity
C4B68_RS17620	COG0346	lactoylglutathione lyase activity
C4B68_RS17640	COG0739	heme binding
C4B68_RS17670	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C4B68_RS17690	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C4B68_RS17700	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C4B68_RS17705	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C4B68_RS17715	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C4B68_RS17735	COG1660	Displays ATPase and GTPase activities
C4B68_RS17740	COG2197	response regulator
C4B68_RS17755	COG0649	NAD binding
C4B68_RS17775	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C4B68_RS17775	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4B68_RS17790	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4B68_RS17805	COG0302	gtp cyclohydrolase
C4B68_RS17820	COG0037	tRNA processing
C4B68_RS17830	COG2027	D-alanyl-D-alanine carboxypeptidase
C4B68_RS17835	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C4B68_RS17850	COG0789	Transcriptional regulator
C4B68_RS17860	COG0076	glutamate decarboxylase activity
C4B68_RS17880	COG1012	belongs to the aldehyde dehydrogenase family
C4B68_RS17915	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4B68_RS17920	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4B68_RS17950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4B68_RS17950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4B68_RS18000	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4B68_RS18005	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4B68_RS18010	COG1754	DNA topoisomerase type I activity
C4B68_RS18010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4B68_RS18035	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C4B68_RS18045	COG1366	Belongs to the anti-sigma-factor antagonist family
C4B68_RS18050	COG1111	helicase
C4B68_RS18050	COG1205	dead DEAH box helicase
C4B68_RS18110	COG0659	secondary active sulfate transmembrane transporter activity
C4B68_RS18115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4B68_RS18120	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4B68_RS18130	COG2267	carboxylic ester hydrolase activity
C4B68_RS18165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4B68_RS18195	COG0003	Pfam Anion-transporting ATPase
C4B68_RS18210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4B68_RS18220	COG1408	metallophosphoesterase
C4B68_RS18270	COG4974	Belongs to the 'phage' integrase family
C4B68_RS18310	COG1846	Transcriptional regulator
C4B68_RS18315	COG0596	Alpha beta hydrolase
C4B68_RS18345	COG1335	isochorismatase
C4B68_RS18350	COG3619	membrane
C4B68_RS18355	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C4B68_RS18370	COG0515	serine threonine protein kinase
C4B68_RS18370	COG2815	serine threonine protein kinase
C4B68_RS18425	COG1609	Transcriptional regulator
C4B68_RS18440	COG0395	ABC-type sugar transport system, permease component
C4B68_RS18480	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C4B68_RS18485	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C4B68_RS18495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C4B68_RS18505	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4B68_RS18510	COG1802	Transcriptional regulator
C4B68_RS18520	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4B68_RS18535	COG1131	(ABC) transporter
C4B68_RS18555	COG2197	response regulator
C4B68_RS18575	COG3844	kynureninase activity
C4B68_RS18580	COG3483	tryptophan 2,3-dioxygenase activity
C4B68_RS18590	COG0477	Major facilitator Superfamily
C4B68_RS18595	COG0191	fructose-bisphosphate aldolase activity
C4B68_RS18600	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C4B68_RS18615	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C4B68_RS18650	COG0542	response to heat
C4B68_RS18680	COG4213	ABC transporter substrate-binding protein
C4B68_RS18720	COG0789	Transcriptional regulator
C4B68_RS18725	COG0484	heat shock protein binding
C4B68_RS18730	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4B68_RS18735	COG0443	Heat shock 70 kDa protein
C4B68_RS18740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4B68_RS18745	COG0247	lactate metabolic process
C4B68_RS18745	COG2181	nitrate reductase activity
C4B68_RS18815	COG0717	Belongs to the dCTP deaminase family
C4B68_RS19110	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
C4B68_RS19170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4B68_RS19175	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4B68_RS19180	COG1120	ATPase activity
C4B68_RS19185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C4B68_RS19205	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4B68_RS19210	COG2124	cytochrome p450
C4B68_RS19240	COG5002	protein histidine kinase activity
C4B68_RS19245	COG0745	RESPONSE REGULATOR receiver
C4B68_RS19300	COG0725	ABC transporter, periplasmic molybdate-binding protein
C4B68_RS19325	COG1278	Cold shock
C4B68_RS19345	COG1595	DNA-templated transcription, initiation
C4B68_RS19360	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C4B68_RS19405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4B68_RS19410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4B68_RS19420	COG1289	transmembrane transporter activity
C4B68_RS19435	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4B68_RS19465	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C4B68_RS19480	COG1741	Belongs to the pirin family
C4B68_RS19490	COG1960	acyl-CoA dehydrogenase activity
C4B68_RS19495	COG1362	aminopeptidase activity
C4B68_RS19525	COG2271	Major facilitator Superfamily
C4B68_RS19540	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4B68_RS19545	COG0022	dehydrogenase e1 component
C4B68_RS19565	COG0515	serine threonine protein kinase
C4B68_RS19570	COG0515	serine threonine protein kinase
C4B68_RS19585	COG1028	Short-chain dehydrogenase reductase Sdr
C4B68_RS19585	COG0604	alcohol dehydrogenase
C4B68_RS19585	COG3321	synthase
C4B68_RS19630	COG1522	sequence-specific DNA binding
C4B68_RS19635	COG1309	transcriptional regulator
C4B68_RS19640	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4B68_RS19665	COG3396	Phenylacetate-CoA oxygenase
C4B68_RS19670	COG3460	Phenylacetate-CoA oxygenase
C4B68_RS19675	COG3396	Phenylacetate-CoA oxygenase
C4B68_RS19680	COG2151	metal-sulfur cluster biosynthetic enzyme
C4B68_RS19685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4B68_RS19710	COG1733	regulation of RNA biosynthetic process
C4B68_RS19715	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4B68_RS19745	COG2267	carboxylic ester hydrolase activity
C4B68_RS19750	COG0778	Nitroreductase
C4B68_RS19755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4B68_RS19785	COG2124	cytochrome p450
C4B68_RS19785	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C4B68_RS19810	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4B68_RS19845	COG1716	ATPase activity
C4B68_RS19850	COG1716	ATPase activity
C4B68_RS19865	COG0768	penicillin binding
C4B68_RS19875	COG0515	serine threonine protein kinase
C4B68_RS19885	COG3764	Sortase (surface protein transpeptidase)
C4B68_RS19890	COG3764	Sortase (surface protein transpeptidase)
C4B68_RS19905	COG3764	Sortase (surface protein transpeptidase)
C4B68_RS19920	COG0705	Rhomboid family
C4B68_RS19945	COG0515	serine threonine protein kinase
C4B68_RS19975	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C4B68_RS19980	COG0187	DNA topoisomerase II activity
C4B68_RS19985	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C4B68_RS19990	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4B68_RS19995	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C4B68_RS20000	COG0592	DNA-directed DNA polymerase activity
C4B68_RS20010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4B68_RS20015	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C4B68_RS20020	COG0594	ribonuclease P activity
C4B68_RS20025	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C4B68_RS20030	COG0706	membrane insertase activity
C4B68_RS20040	COG0357	Ribosomal RNA small subunit methyltransferase G
C4B68_RS20045	COG1192	Involved in chromosome partitioning
C4B68_RS20060	COG3118	belongs to the thioredoxin family
C4B68_RS20065	COG0492	ferredoxin-NADP+ reductase activity
C4B68_RS20075	COG1595	DNA-templated transcription, initiation
C4B68_RS20080	COG0515	serine threonine protein kinase
C4B68_RS20080	COG2815	serine threonine protein kinase
C4B68_RS20095	COG0617	tRNA 3'-terminal CCA addition
C4B68_RS20120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4B68_RS20145	COG0360	Binds together with S18 to 16S ribosomal RNA
C4B68_RS20150	COG0629	single-stranded DNA binding
C4B68_RS20155	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4B68_RS20160	COG0359	binds to the 23S rRNA
C4B68_RS20170	COG0305	Participates in initiation and elongation during chromosome replication
C4B68_RS20200	COG2814	Major facilitator Superfamily
C4B68_RS20235	COG0626	cystathionine gamma-synthase activity
C4B68_RS20240	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4B68_RS20245	COG1950	PFAM Membrane protein of
C4B68_RS20250	COG0662	Cupin 2, conserved barrel domain protein
C4B68_RS20275	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C4B68_RS20295	COG1609	Transcriptional regulator
C4B68_RS20300	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4B68_RS20305	COG1271	oxidase subunit
C4B68_RS20310	COG1294	oxidase, subunit
C4B68_RS20315	COG4988	ABC transporter
C4B68_RS20325	COG0561	phosphatase activity
C4B68_RS20335	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
C4B68_RS20340	COG0789	Transcriptional regulator
C4B68_RS20385	COG0561	phosphatase activity
C4B68_RS20390	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4B68_RS20400	COG2837	iron assimilation
C4B68_RS20415	COG1999	signal sequence binding
C4B68_RS20440	COG0006	proline dipeptidase activity
C4B68_RS20460	COG0653	protein targeting
C4B68_RS20475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4B68_RS20535	COG1595	DNA-templated transcription, initiation
C4B68_RS20540	COG0318	PFAM AMP-dependent synthetase and ligase
C4B68_RS20550	COG1309	transcriptional regulator
C4B68_RS20780	COG2329	Antibiotic biosynthesis monooxygenase
C4B68_RS20790	COG0745	RESPONSE REGULATOR receiver
C4B68_RS20825	COG3467	pyridoxamine 5'-phosphate
C4B68_RS20835	COG0477	Major facilitator Superfamily
C4B68_RS20855	COG1191	sigma factor activity
C4B68_RS20860	COG1191	sigma factor activity
C4B68_RS20875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4B68_RS20905	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4B68_RS20920	COG0433	COG0433 Predicted ATPase
C4B68_RS20970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4B68_RS20980	COG2770	Histidine kinase
C4B68_RS20980	COG2208	phosphoserine phosphatase activity
C4B68_RS21000	COG0151	Belongs to the GarS family
C4B68_RS21015	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C4B68_RS21050	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4B68_RS21055	COG0047	phosphoribosylformylglycinamidine synthase activity
C4B68_RS21060	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4B68_RS21090	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C4B68_RS21100	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C4B68_RS21125	COG1643	Atp-dependent helicase
C4B68_RS21165	COG0513	Belongs to the DEAD box helicase family
C4B68_RS21215	COG1061	Type III restriction enzyme res subunit
C4B68_RS21420	COG0596	Alpha beta hydrolase
C4B68_RS21430	COG0805	protein transport
C4B68_RS21435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4B68_RS21445	COG1309	transcriptional regulator
C4B68_RS21465	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4B68_RS21465	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4B68_RS21490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4B68_RS21495	COG0579	oxidoreductase
C4B68_RS21520	COG1252	NADH dehydrogenase
C4B68_RS21635	COG0739	heme binding
C4B68_RS21635	COG1196	nuclear chromosome segregation
C4B68_RS21635	COG0741	lytic transglycosylase activity
C4B68_RS21640	COG0671	phosphoesterase, PA-phosphatase related
C4B68_RS21645	COG0277	FAD linked oxidase domain protein
C4B68_RS21660	COG1937	Protein conserved in bacteria
C4B68_RS21670	COG0306	phosphate transporter
C4B68_RS21675	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4B68_RS21705	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C4B68_RS21710	COG0456	acetyltransferase
C4B68_RS21720	COG0737	Belongs to the 5'-nucleotidase family
C4B68_RS21730	COG0745	RESPONSE REGULATOR receiver
C4B68_RS21740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4B68_RS21750	COG1609	Transcriptional regulator
C4B68_RS21755	COG0745	RESPONSE REGULATOR receiver
C4B68_RS21780	COG2897	thiosulfate sulfurtransferase activity
C4B68_RS21825	COG3485	protocatechuate 3,4-dioxygenase
C4B68_RS21835	COG0354	folic acid binding
C4B68_RS21840	COG1490	D-aminoacyl-tRNA deacylase activity
C4B68_RS21850	COG4552	Acetyltransferase involved in intracellular survival and related
C4B68_RS21860	COG2188	Transcriptional regulator
C4B68_RS21865	COG2188	Transcriptional regulator
C4B68_RS21880	COG2188	Transcriptional regulator
C4B68_RS21905	COG1028	Short-chain dehydrogenase reductase Sdr
C4B68_RS21930	COG1595	DNA-templated transcription, initiation
C4B68_RS21970	COG0438	transferase activity, transferring glycosyl groups
C4B68_RS21995	COG0588	phosphoglycerate mutase activity
C4B68_RS22015	COG5002	protein histidine kinase activity
C4B68_RS22035	COG1329	Transcriptional regulator
C4B68_RS22040	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C4B68_RS22045	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C4B68_RS22050	COG0215	cysteine-tRNA ligase activity
C4B68_RS22055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4B68_RS22075	COG3842	ATPase activity
C4B68_RS22100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4B68_RS22100	COG0723	plastoquinol--plastocyanin reductase activity
C4B68_RS22110	COG1233	COG1233 Phytoene dehydrogenase and related
C4B68_RS22125	COG2018	Roadblock/LC7 domain
C4B68_RS22155	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4B68_RS22180	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C4B68_RS22210	COG0463	Glycosyl transferase, family 2
C4B68_RS22225	COG1278	Cold shock
C4B68_RS22230	COG0459	protein refolding
C4B68_RS22265	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C4B68_RS22270	COG1737	Transcriptional regulator
C4B68_RS22300	COG3142	Participates in the control of copper homeostasis
C4B68_RS22305	COG3973	AAA domain
C4B68_RS22320	COG1061	Type III restriction enzyme res subunit
C4B68_RS22345	COG1278	Cold shock
C4B68_RS22350	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C4B68_RS22355	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4B68_RS22365	COG2814	Major facilitator Superfamily
C4B68_RS22390	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4B68_RS22400	COG2252	PERMEase
C4B68_RS22410	COG1846	Transcriptional regulator
C4B68_RS22425	COG0667	Aldo Keto reductase
C4B68_RS22495	COG1595	DNA-templated transcription, initiation
C4B68_RS22515	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C4B68_RS22520	COG2124	cytochrome p450
C4B68_RS22540	COG0247	lactate metabolic process
C4B68_RS22540	COG0277	FAD linked oxidase domain protein
C4B68_RS22565	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C4B68_RS22570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4B68_RS22585	COG0318	PFAM AMP-dependent synthetase and ligase
C4B68_RS22590	COG1024	Enoyl-CoA hydratase
C4B68_RS22600	COG0259	pyridoxamine-phosphate oxidase activity
C4B68_RS22620	COG4821	SIS domain
C4B68_RS22630	COG0596	Alpha beta hydrolase
C4B68_RS22630	COG2945	thiolester hydrolase activity
C4B68_RS22680	COG1595	DNA-templated transcription, initiation
C4B68_RS22695	COG0318	PFAM AMP-dependent synthetase and ligase
C4B68_RS22705	COG1960	acyl-CoA dehydrogenase activity
C4B68_RS22710	COG1960	acyl-CoA dehydrogenase activity
C4B68_RS22730	COG1028	Short-chain dehydrogenase reductase Sdr
C4B68_RS22735	COG1960	acyl-CoA dehydrogenase activity
C4B68_RS22740	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C4B68_RS22765	COG1024	Enoyl-CoA hydratase
C4B68_RS22775	COG2072	flavoprotein involved in K transport
C4B68_RS22795	COG0259	pyridoxamine-phosphate oxidase activity
C4B68_RS22810	COG1960	acyl-CoA dehydrogenase activity
C4B68_RS22820	COG1309	transcriptional regulator
C4B68_RS22835	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4B68_RS22835	COG0515	serine threonine protein kinase
C4B68_RS22845	COG1024	Enoyl-CoA hydratase
C4B68_RS22880	COG3903	Transcriptional regulator
C4B68_RS22880	COG3629	intracellular signal transduction
C4B68_RS22895	COG1028	Short-chain dehydrogenase reductase Sdr
C4B68_RS22905	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C4B68_RS22925	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C4B68_RS22970	COG1686	Belongs to the peptidase S11 family
C4B68_RS22985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4B68_RS22995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4B68_RS23010	COG0386	Belongs to the glutathione peroxidase family
C4B68_RS23090	COG1414	Transcriptional regulator
C4B68_RS23110	COG1846	Transcriptional regulator
C4B68_RS23115	COG3384	dioxygenase
C4B68_RS23120	COG1247	-acetyltransferase
C4B68_RS23140	COG0477	Major facilitator Superfamily
C4B68_RS23145	COG1349	DNA-binding transcription factor activity
C4B68_RS23155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4B68_RS23155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4B68_RS23155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4B68_RS23180	COG1970	mechanosensitive ion channel activity
C4B68_RS23190	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C4B68_RS23210	COG3263	regulation of cellular component size
C4B68_RS23215	COG2366	antibiotic biosynthetic process
C4B68_RS23220	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4B68_RS23225	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C4B68_RS23235	COG0315	cyclic pyranopterin monophosphate synthase activity
C4B68_RS23240	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4B68_RS23240	COG0315	cyclic pyranopterin monophosphate synthase activity
C4B68_RS23245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4B68_RS23265	COG0708	Exodeoxyribonuclease III
C4B68_RS23275	COG2072	flavoprotein involved in K transport
C4B68_RS23280	COG2267	carboxylic ester hydrolase activity
C4B68_RS23285	COG1028	Short-chain dehydrogenase reductase Sdr
C4B68_RS23295	COG0793	Belongs to the peptidase S41A family
C4B68_RS23295	COG4946	Tricorn protease homolog
C4B68_RS23305	COG2409	Drug exporters of the RND superfamily
C4B68_RS23315	COG0310	cobalt ion transport
C4B68_RS23325	COG1122	ATPase activity
C4B68_RS23330	COG1846	Transcriptional regulator
C4B68_RS23335	COG1764	response to oxidative stress
C4B68_RS23375	COG0084	hydrolase, TatD family'
C4B68_RS23385	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4B68_RS23390	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C4B68_RS23395	COG0488	(ABC) transporter
C4B68_RS23440	COG0582	viral genome integration into host DNA
C4B68_RS23490	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C4B68_RS23500	COG2197	response regulator
C4B68_RS23510	COG4106	trans-aconitate 2-methyltransferase activity
C4B68_RS23515	COG1309	transcriptional regulator
C4B68_RS23525	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C4B68_RS23550	COG0193	aminoacyl-tRNA hydrolase activity
C4B68_RS23555	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C4B68_RS23560	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4B68_RS23565	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4B68_RS23580	COG4585	Histidine kinase
C4B68_RS23610	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4B68_RS23625	COG0477	Major facilitator Superfamily
C4B68_RS23630	COG1136	(ABC) transporter
C4B68_RS23635	COG0577	efflux transmembrane transporter activity
C4B68_RS23710	COG2124	cytochrome p450
C4B68_RS23725	COG0148	phosphopyruvate hydratase activity
C4B68_RS23745	COG1252	NADH dehydrogenase
C4B68_RS23750	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4B68_RS23755	COG0577	efflux transmembrane transporter activity
C4B68_RS23760	COG1136	(ABC) transporter
C4B68_RS23790	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4B68_RS23795	COG1993	acr, cog1993
C4B68_RS23800	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4B68_RS23840	COG0183	Belongs to the thiolase family
C4B68_RS23845	COG2755	lipolytic protein G-D-S-L family
C4B68_RS23875	COG1174	glycine betaine transport
C4B68_RS23885	COG2986	histidine ammonia-lyase
C4B68_RS23905	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C4B68_RS23920	COG1228	amidohydrolase
C4B68_RS23930	COG1191	sigma factor activity
C4B68_RS23935	COG1366	Belongs to the anti-sigma-factor antagonist family
C4B68_RS23970	COG3104	oligopeptide transport
C4B68_RS23975	COG0745	RESPONSE REGULATOR receiver
C4B68_RS23980	COG2205	protein histidine kinase activity
C4B68_RS24020	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C4B68_RS24030	COG1316	TRANSCRIPTIONal
C4B68_RS24050	COG1316	TRANSCRIPTIONal
C4B68_RS24055	COG1316	TRANSCRIPTIONal
C4B68_RS24085	COG0778	Nitroreductase
C4B68_RS24085	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
C4B68_RS24090	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C4B68_RS24130	COG1620	l-lactate permease
C4B68_RS24135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4B68_RS24140	COG2835	tetraacyldisaccharide 4'-kinase activity
C4B68_RS24150	COG1482	cell wall glycoprotein biosynthetic process
C4B68_RS24160	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C4B68_RS24205	COG0714	Associated with various cellular activities
C4B68_RS24225	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C4B68_RS24230	COG0745	RESPONSE REGULATOR receiver
C4B68_RS24235	COG5002	protein histidine kinase activity
C4B68_RS24235	COG5000	phosphorelay sensor kinase activity
C4B68_RS24240	COG0823	Involved in the tonB-independent uptake of proteins
C4B68_RS24255	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C4B68_RS24260	COG2197	response regulator
C4B68_RS24265	COG3214	Protein conserved in bacteria
C4B68_RS24275	COG0653	protein targeting
C4B68_RS24340	COG4195	phage-related replication protein
C4B68_RS24495	COG0629	single-stranded DNA binding
C4B68_RS24580	COG2902	Dehydrogenase
C4B68_RS24590	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C4B68_RS24590	COG0463	Glycosyl transferase, family 2
C4B68_RS24595	COG0438	transferase activity, transferring glycosyl groups
C4B68_RS24600	COG1134	teichoic acid transport
C4B68_RS24635	COG1846	Transcriptional regulator
C4B68_RS24640	COG1764	response to oxidative stress
C4B68_RS24660	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C4B68_RS24665	COG0463	Glycosyl transferase, family 2
C4B68_RS24665	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C4B68_RS24670	COG0395	ABC-type sugar transport system, permease component
C4B68_RS24675	COG1175	transmembrane transport
C4B68_RS24690	COG1674	ftsk spoiiie
C4B68_RS24695	COG0515	serine threonine protein kinase
C4B68_RS24700	COG0515	serine threonine protein kinase
C4B68_RS24705	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C4B68_RS24720	COG2884	Cell division ATP-binding protein ftsE
C4B68_RS24730	COG0793	Belongs to the peptidase S41A family
C4B68_RS24735	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C4B68_RS24750	COG0583	DNA-binding transcription factor activity
C4B68_RS24845	COG2223	nitrite transmembrane transporter activity
C4B68_RS24870	COG3973	AAA domain
C4B68_RS24880	COG0776	regulation of translation
C4B68_RS24885	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4B68_RS24890	COG1678	Uncharacterized ACR, COG1678
C4B68_RS24915	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C4B68_RS24950	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4B68_RS25010	COG3480	Lon protease (S16) C-terminal proteolytic domain
C4B68_RS25020	COG1174	glycine betaine transport
C4B68_RS25025	COG0517	IMP dehydrogenase activity
C4B68_RS25025	COG1125	glycine betaine transport
C4B68_RS25030	COG1174	glycine betaine transport
C4B68_RS25040	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C4B68_RS25050	COG0277	FAD linked oxidase domain protein
C4B68_RS25085	COG1335	isochorismatase
C4B68_RS25095	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C4B68_RS25110	COG1113	amino acid transport
C4B68_RS25140	COG1234	tRNA 3'-trailer cleavage
C4B68_RS25145	COG1263	PTS System
C4B68_RS25150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4B68_RS25155	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C4B68_RS25165	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C4B68_RS25195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4B68_RS25210	COG4555	ABC transporter
C4B68_RS25225	COG2733	membrane
C4B68_RS25230	COG2814	Major facilitator Superfamily
C4B68_RS25295	COG1403	HNH endonuclease
C4B68_RS25325	COG3764	Sortase (surface protein transpeptidase)
C4B68_RS25355	COG4702	Belongs to the UPF0303 family
C4B68_RS25360	COG0673	inositol 2-dehydrogenase activity
C4B68_RS25365	COG1940	carbohydrate kinase activity
C4B68_RS25380	COG2188	Transcriptional regulator
C4B68_RS25385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4B68_RS25455	COG3397	chitin binding
C4B68_RS25470	COG1126	abc transporter atp-binding protein
C4B68_RS25475	COG0765	amino acid transport
C4B68_RS25480	COG0765	amino acid transport
C4B68_RS25485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4B68_RS25495	COG0154	amidase activity
C4B68_RS25500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4B68_RS25515	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4B68_RS25520	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C4B68_RS25525	COG2080	2 iron, 2 sulfur cluster binding
C4B68_RS25530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4B68_RS25580	COG0406	alpha-ribazole phosphatase activity
C4B68_RS25610	COG0745	RESPONSE REGULATOR receiver
C4B68_RS25620	COG3979	chitinase
C4B68_RS25635	COG2409	Drug exporters of the RND superfamily
C4B68_RS25675	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C4B68_RS25680	COG4977	sequence-specific DNA binding
C4B68_RS25690	COG0589	response to stress
C4B68_RS25700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4B68_RS25735	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C4B68_RS25745	COG2375	cellular response to nickel ion
C4B68_RS25755	COG0768	penicillin binding
C4B68_RS25760	COG1960	acyl-CoA dehydrogenase activity
C4B68_RS25775	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4B68_RS25780	COG1309	transcriptional regulator
C4B68_RS25790	COG1946	Acyl-CoA thioesterase
C4B68_RS25805	COG0028	Belongs to the TPP enzyme family
C4B68_RS25815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4B68_RS25825	COG2356	endonuclease I
C4B68_RS25855	COG1472	Belongs to the glycosyl hydrolase 3 family
C4B68_RS25865	COG0318	PFAM AMP-dependent synthetase and ligase
C4B68_RS25885	COG0456	acetyltransferase
C4B68_RS25885	COG1846	Transcriptional regulator
C4B68_RS25890	COG1609	Transcriptional regulator
C4B68_RS25895	COG0673	inositol 2-dehydrogenase activity
C4B68_RS25920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4B68_RS25955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4B68_RS25965	COG3718	enzyme involved in inositol metabolism
C4B68_RS25970	COG3962	Belongs to the TPP enzyme family
C4B68_RS25995	COG1022	Amp-dependent synthetase and ligase
C4B68_RS26050	COG0629	single-stranded DNA binding
C4B68_RS26070	COG2186	Transcriptional regulator
C4B68_RS26260	COG0438	transferase activity, transferring glycosyl groups
C4B68_RS26265	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C4B68_RS26270	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4B68_RS26290	COG0489	protein tyrosine kinase activity
C4B68_RS26360	COG2346	COG2346, Truncated hemoglobins
C4B68_RS26365	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4B68_RS26395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4B68_RS26405	COG3973	AAA domain
C4B68_RS26410	COG0668	transmembrane transport
C4B68_RS26425	COG1136	(ABC) transporter
C4B68_RS26435	COG3291	Pkd domain containing protein
C4B68_RS26435	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C4B68_RS26495	COG2337	Toxic component of a toxin-antitoxin (TA) module
C4B68_RS26545	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C4B68_RS26580	COG1113	amino acid transport
C4B68_RS26595	COG0515	serine threonine protein kinase
C4B68_RS26600	COG1113	amino acid transport
C4B68_RS26615	COG4552	Acetyltransferase involved in intracellular survival and related
C4B68_RS26630	COG3594	Acyltransferase
C4B68_RS26650	COG0544	peptidyl-prolyl cis-trans isomerase activity
C4B68_RS26655	COG0740	serine-type endopeptidase activity
C4B68_RS26660	COG0740	serine-type endopeptidase activity
C4B68_RS26665	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C4B68_RS26675	COG0525	valine-tRNA ligase activity
C4B68_RS26680	COG0285	dihydrofolate synthase activity
C4B68_RS26690	COG0105	UTP biosynthetic process
C4B68_RS26695	COG1077	Cell shape determining protein MreB Mrl
C4B68_RS26715	COG0772	Belongs to the SEDS family
C4B68_RS26755	COG2186	Transcriptional regulator
C4B68_RS26800	COG1530	ribonuclease E activity
C4B68_RS26805	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C4B68_RS26810	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C4B68_RS26815	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4B68_RS26820	COG3540	Alkaline phosphatase
C4B68_RS26840	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C4B68_RS26850	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C4B68_RS26870	COG0501	Belongs to the peptidase M48B family
C4B68_RS26875	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4B68_RS26885	COG0799	negative regulation of ribosome biogenesis
C4B68_RS26890	COG0588	phosphoglycerate mutase activity
C4B68_RS26930	COG0495	leucyl-tRNA aminoacylation
C4B68_RS26940	COG1307	EDD domain protein, DegV family
C4B68_RS26945	COG1555	photosystem II stabilization
C4B68_RS26945	COG1596	polysaccharide export
C4B68_RS26970	COG0268	Binds directly to 16S ribosomal RNA
C4B68_RS26980	COG0481	GTPase activity
C4B68_RS27020	COG1420	regulation of RNA biosynthetic process
C4B68_RS27025	COG0484	heat shock protein binding
C4B68_RS27055	COG0793	Belongs to the peptidase S41A family
C4B68_RS27055	COG4946	Tricorn protease homolog
C4B68_RS27060	COG0537	adenosine 5'-monophosphoramidase activity
C4B68_RS27065	COG1234	tRNA 3'-trailer cleavage
C4B68_RS27070	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4B68_RS27100	COG0004	ammonium transporteR
C4B68_RS27105	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4B68_RS27110	COG2197	response regulator
C4B68_RS27125	COG2315	Protein conserved in bacteria
C4B68_RS27135	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4B68_RS27155	COG2723	6-phospho-beta-galactosidase activity
C4B68_RS27175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4B68_RS27185	COG2409	Drug exporters of the RND superfamily
C4B68_RS27190	COG4585	Histidine kinase
C4B68_RS27205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4B68_RS27210	COG4608	Belongs to the ABC transporter superfamily
C4B68_RS27215	COG0444	Belongs to the ABC transporter superfamily
C4B68_RS27225	COG0747	negative chemotaxis
C4B68_RS27230	COG2186	Transcriptional regulator
C4B68_RS27240	COG1381	Involved in DNA repair and RecF pathway recombination
C4B68_RS27245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4B68_RS27255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4B68_RS27260	COG1121	(ABC) transporter
C4B68_RS27265	COG3443	Belongs to the bacterial solute-binding protein 9 family
C4B68_RS27265	COG0803	Belongs to the bacterial solute-binding protein 9 family
C4B68_RS27270	COG0423	glycine-tRNA ligase activity
C4B68_RS27285	COG0667	Aldo Keto reductase
C4B68_RS27330	COG1846	Transcriptional regulator
C4B68_RS27330	COG1940	carbohydrate kinase activity
C4B68_RS27335	COG0574	Belongs to the PEP-utilizing enzyme family
C4B68_RS27335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4B68_RS27365	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C4B68_RS27375	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4B68_RS27375	COG2146	nitrite reductase [NAD(P)H] activity
C4B68_RS27380	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4B68_RS27390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4B68_RS27445	COG0243	molybdopterin cofactor binding
C4B68_RS27460	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C4B68_RS27470	COG0358	DNA primase activity
C4B68_RS27475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4B68_RS27490	COG1070	Carbohydrate kinase
C4B68_RS27530	COG3629	intracellular signal transduction
C4B68_RS27530	COG3903	Transcriptional regulator
C4B68_RS27560	COG1077	Cell shape determining protein MreB Mrl
C4B68_RS27565	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C4B68_RS27565	COG0825	malonyl-CoA metabolic process
C4B68_RS27570	COG0318	PFAM AMP-dependent synthetase and ligase
C4B68_RS27625	COG4981	capsule polysaccharide biosynthetic process
C4B68_RS27630	COG0500	methyltransferase
C4B68_RS27650	COG1414	Transcriptional regulator
C4B68_RS27655	COG3386	PFAM SMP-30 Gluconolaconase
C4B68_RS27665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4B68_RS27670	COG4214	carbohydrate transport
C4B68_RS27680	COG4213	ABC transporter substrate-binding protein
C4B68_RS27695	COG4948	Mandelate Racemase Muconate Lactonizing
C4B68_RS27725	COG2130	NADP-dependent
C4B68_RS27760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4B68_RS27765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4B68_RS27770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4B68_RS27785	COG1741	Belongs to the pirin family
C4B68_RS27800	COG0789	Transcriptional regulator
C4B68_RS27820	COG1309	transcriptional regulator
C4B68_RS27825	COG0477	Major facilitator Superfamily
C4B68_RS27830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4B68_RS27835	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C4B68_RS27885	COG1358	cellular component organization or biogenesis
C4B68_RS27900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4B68_RS27970	COG1595	DNA-templated transcription, initiation
C4B68_RS27990	COG1309	transcriptional regulator
C4B68_RS28005	COG2226	methyltransferase
C4B68_RS28065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4B68_RS28070	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4B68_RS28090	COG2132	Multicopper oxidase
C4B68_RS28115	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4B68_RS28180	COG4122	O-methyltransferase activity
C4B68_RS28195	COG2124	cytochrome p450
C4B68_RS28200	COG0183	Belongs to the thiolase family
C4B68_RS28220	COG3619	membrane
C4B68_RS28235	COG3845	ABC transporter
C4B68_RS28250	COG1657	PFAM Prenyltransferase squalene oxidase
C4B68_RS28270	COG1309	transcriptional regulator
C4B68_RS28310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4B68_RS28340	COG2197	response regulator
C4B68_RS28345	COG4585	Histidine kinase
C4B68_RS28350	COG2030	dehydratase
C4B68_RS28360	COG1028	Short-chain dehydrogenase reductase Sdr
C4B68_RS28375	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C4B68_RS28390	COG0800	Aldolase
C4B68_RS28395	COG3022	response to hydroperoxide
C4B68_RS28400	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C4B68_RS28435	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4B68_RS28445	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4B68_RS28450	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4B68_RS28455	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C4B68_RS28505	COG1201	RNA secondary structure unwinding
C4B68_RS28535	COG0210	DNA helicase
C4B68_RS28645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4B68_RS28645	COG0574	Belongs to the PEP-utilizing enzyme family
C4B68_RS28655	COG1078	dGTPase activity
C4B68_RS28680	COG3345	alpha-galactosidase
C4B68_RS28690	COG1960	acyl-CoA dehydrogenase activity
C4B68_RS28710	COG2018	Roadblock/LC7 domain
C4B68_RS28720	COG1404	Belongs to the peptidase S8 family
C4B68_RS28745	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C4B68_RS28775	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4B68_RS28845	COG2814	Major facilitator Superfamily
C4B68_RS28850	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C4B68_RS28880	COG0672	)-iron permease
C4B68_RS28885	COG2837	iron assimilation
C4B68_RS28935	COG1994	Peptidase M50
C4B68_RS28955	COG2814	Major facilitator Superfamily
C4B68_RS28970	COG0477	Major facilitator Superfamily
C4B68_RS28975	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4B68_RS28980	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4B68_RS28980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4B68_RS28995	COG1959	2 iron, 2 sulfur cluster binding
C4B68_RS29000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4B68_RS29000	COG1017	nitric oxide dioxygenase activity
C4B68_RS29005	COG0174	glutamine synthetase
C4B68_RS29035	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C4B68_RS29055	COG1609	Transcriptional regulator
C4B68_RS29065	COG1175	transmembrane transport
C4B68_RS29070	COG3833	ABC-type maltose transport systems, permease component
C4B68_RS29075	COG0366	Alpha amylase catalytic
C4B68_RS29100	COG1309	transcriptional regulator
C4B68_RS29130	COG0745	RESPONSE REGULATOR receiver
C4B68_RS29190	COG0501	Belongs to the peptidase M48B family
C4B68_RS29200	COG0174	glutamine synthetase
C4B68_RS29220	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C4B68_RS29225	COG0321	lipoyl(octanoyl) transferase activity
C4B68_RS29250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4B68_RS29270	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C4B68_RS29280	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4B68_RS29285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4B68_RS29290	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C4B68_RS29300	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C4B68_RS29310	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C4B68_RS29330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4B68_RS29335	COG2226	methyltransferase
C4B68_RS29355	COG4585	Histidine kinase
C4B68_RS29360	COG2197	response regulator
C4B68_RS29365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4B68_RS29375	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C4B68_RS29395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4B68_RS29400	COG1104	cysteine desulfurase activity
C4B68_RS29405	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4B68_RS29410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4B68_RS29420	COG1376	ErfK ybiS ycfS ynhG family protein
C4B68_RS29430	COG1845	cytochrome c oxidase, subunit III
C4B68_RS29435	COG2010	Cytochrome c
C4B68_RS29440	COG0723	plastoquinol--plastocyanin reductase activity
C4B68_RS29445	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C4B68_RS29450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4B68_RS29455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4B68_RS29520	COG0003	Pfam Anion-transporting ATPase
C4B68_RS29530	COG1940	carbohydrate kinase activity
C4B68_RS29555	COG4585	Histidine kinase
C4B68_RS29560	COG2197	response regulator
C4B68_RS29565	COG0205	6-phosphofructokinase activity
C4B68_RS29580	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C4B68_RS29585	COG0243	molybdopterin cofactor binding
C4B68_RS29590	COG2193	ferroxidase activity
C4B68_RS29595	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C4B68_RS29600	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C4B68_RS29605	COG2815	serine threonine protein kinase
C4B68_RS29605	COG0515	serine threonine protein kinase
C4B68_RS29610	COG2022	thiamine diphosphate biosynthetic process
C4B68_RS29620	COG2022	thiamine diphosphate biosynthetic process
C4B68_RS29620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4B68_RS29640	COG0352	thiamine-phosphate diphosphorylase activity
C4B68_RS29655	COG1233	COG1233 Phytoene dehydrogenase and related
C4B68_RS29660	COG1309	transcriptional regulator
C4B68_RS29670	COG1121	(ABC) transporter
C4B68_RS29680	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4B68_RS29700	COG0714	Associated with various cellular activities
C4B68_RS29710	COG0275	rRNA processing
C4B68_RS29720	COG0768	penicillin binding
C4B68_RS29725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4B68_RS29735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4B68_RS29740	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4B68_RS29750	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4B68_RS29755	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C4B68_RS29760	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C4B68_RS29765	COG1496	oxidoreductase activity
C4B68_RS29775	COG1799	cell septum assembly
C4B68_RS29785	COG3599	regulation of cell shape
C4B68_RS29790	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4B68_RS29800	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C4B68_RS29810	COG2153	protein acetylation
C4B68_RS29860	COG0587	DNA-directed DNA polymerase activity
C4B68_RS29870	COG1432	Conserved Protein
C4B68_RS29895	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4B68_RS29915	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C4B68_RS29920	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4B68_RS29925	COG0131	Imidazoleglycerol-phosphate dehydratase
C4B68_RS29930	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4B68_RS29935	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C4B68_RS29940	COG0251	oxidation-reduction process
C4B68_RS29945	COG0107	imidazoleglycerol-phosphate synthase activity
C4B68_RS29985	COG0134	indole-3-glycerol-phosphate synthase activity
C4B68_RS29995	COG0133	tryptophan synthase activity
C4B68_RS30000	COG0159	tryptophan synthase activity
C4B68_RS30010	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C4B68_RS30015	COG2301	Belongs to the HpcH HpaI aldolase family
C4B68_RS30020	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4B68_RS30025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4B68_RS30060	COG0067	glutamate synthase
C4B68_RS30060	COG0069	glutamate synthase activity
C4B68_RS30060	COG0070	glutamate synthase
C4B68_RS30095	COG1960	acyl-CoA dehydrogenase activity
C4B68_RS30100	COG1960	acyl-CoA dehydrogenase activity
C4B68_RS30110	COG1309	transcriptional regulator
C4B68_RS30115	COG0183	Belongs to the thiolase family
C4B68_RS30140	COG1024	Enoyl-CoA hydratase
C4B68_RS30150	COG1028	Short-chain dehydrogenase reductase Sdr
C4B68_RS30165	COG1605	Chorismate mutase
C4B68_RS30165	COG0287	Prephenate dehydrogenase
C4B68_RS30245	COG2050	protein possibly involved in aromatic compounds catabolism
C4B68_RS30285	COG1643	Atp-dependent helicase
C4B68_RS30290	COG2226	methyltransferase
C4B68_RS30295	COG0539	negative regulation of cytoplasmic translation
C4B68_RS30310	COG0237	dephospho-CoA kinase activity
C4B68_RS30335	COG2226	methyltransferase
C4B68_RS30355	COG2267	carboxylic ester hydrolase activity
C4B68_RS30475	COG0598	Magnesium transport protein CorA
C4B68_RS30480	COG2226	methyltransferase
C4B68_RS30490	COG2313	pseudouridylate synthase activity
C4B68_RS30500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4B68_RS30505	COG0584	glycerophosphoryl diester phosphodiesterase
C4B68_RS30515	COG0556	nucleotide-excision repair
C4B68_RS30540	COG0477	Major facilitator Superfamily
C4B68_RS30545	COG1619	proteins homologs of microcin C7 resistance protein MccF
C4B68_RS30550	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4B68_RS30560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4B68_RS30570	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4B68_RS30590	COG1609	Transcriptional regulator
C4B68_RS30605	COG0322	excinuclease ABC activity
C4B68_RS30610	COG1660	Displays ATPase and GTPase activities
C4B68_RS30615	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C4B68_RS30620	COG1481	regulation of sporulation
C4B68_RS30635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C4B68_RS30640	COG0126	phosphoglycerate kinase activity
C4B68_RS30645	COG0149	triose-phosphate isomerase activity
C4B68_RS30650	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C4B68_RS30665	COG0166	Belongs to the GPI family
C4B68_RS30680	COG1136	(ABC) transporter
C4B68_RS30685	COG1695	Transcriptional regulator
C4B68_RS30690	COG1653	transport
C4B68_RS30695	COG0366	Alpha amylase catalytic
C4B68_RS30705	COG1175	transmembrane transport
C4B68_RS30710	COG0395	ABC-type sugar transport system, permease component
C4B68_RS30715	COG0363	glucosamine-6-phosphate deaminase activity
C4B68_RS30730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4B68_RS30745	COG0109	protoheme IX farnesyltransferase activity
C4B68_RS30775	COG1131	(ABC) transporter
C4B68_RS30780	COG2746	aminoglycoside 3-N-acetyltransferase activity
C4B68_RS30795	COG0719	Fe-S assembly protein
C4B68_RS30805	COG0396	ATPase activity
C4B68_RS30810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4B68_RS30815	COG0822	iron-sulfur transferase activity
C4B68_RS30820	COG2151	metal-sulfur cluster biosynthetic enzyme
C4B68_RS30825	COG2076	Multidrug Resistance protein
C4B68_RS30830	COG3226	Transcriptional regulator
C4B68_RS30835	COG2171	N-acyltransferase activity
C4B68_RS30855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4B68_RS30900	COG1063	alcohol dehydrogenase
C4B68_RS30905	COG0395	ABC-type sugar transport system, permease component
C4B68_RS30925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4B68_RS30935	COG2252	PERMEase
C4B68_RS30940	COG0768	penicillin binding
C4B68_RS30945	COG1414	Transcriptional regulator
C4B68_RS30965	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4B68_RS30970	COG1595	DNA-templated transcription, initiation
C4B68_RS30980	COG5285	phytanoyl-CoA dioxygenase
C4B68_RS30985	COG1917	Cupin 2, conserved barrel domain protein
C4B68_RS30990	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4B68_RS30995	COG0456	acetyltransferase
C4B68_RS31005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4B68_RS31010	COG0765	amino acid transport
C4B68_RS31035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C4B68_RS31050	COG0667	Aldo Keto reductase
C4B68_RS31115	COG1797	cobyrinic acid a,c-diamide synthase activity
C4B68_RS31120	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C4B68_RS31135	COG1492	cobalamin metabolic process
C4B68_RS31140	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C4B68_RS31160	COG0235	Class ii aldolase
C4B68_RS31190	COG0488	(ABC) transporter
C4B68_RS31240	COG3387	PFAM Glycoside hydrolase 15-related
C4B68_RS31255	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4B68_RS31275	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4B68_RS31290	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4B68_RS31295	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4B68_RS31320	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C4B68_RS31330	COG0312	modulator of DNA gyrase
C4B68_RS31335	COG1028	Short-chain dehydrogenase reductase Sdr
C4B68_RS31350	COG2186	Transcriptional regulator
C4B68_RS31370	COG0588	phosphoglycerate mutase activity
C4B68_RS31375	COG0560	Phosphoserine phosphatase
C4B68_RS31375	COG3830	Belongs to the UPF0237 family
C4B68_RS31385	COG1716	ATPase activity
C4B68_RS31385	COG1131	(ABC) transporter
C4B68_RS31385	COG0842	Transport permease protein
C4B68_RS31395	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4B68_RS31400	COG4221	oxidoreductase activity
C4B68_RS31410	COG2197	response regulator
C4B68_RS31430	COG1119	ATPase activity
C4B68_RS31450	COG1881	PFAM PEBP family protein
C4B68_RS31460	COG2094	Belongs to the DNA glycosylase MPG family
C4B68_RS31510	COG0647	UMP catabolic process
C4B68_RS31515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4B68_RS31520	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4B68_RS31525	COG1120	ATPase activity
C4B68_RS31545	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4B68_RS31550	COG0497	DNA recombination
C4B68_RS31555	COG0297	glycogen (starch) synthase activity
C4B68_RS31605	COG3387	PFAM Glycoside hydrolase 15-related
C4B68_RS31610	COG0504	CTP synthase activity
C4B68_RS31615	COG0494	nUDIX hydrolase
C4B68_RS31625	COG0686	Belongs to the AlaDH PNT family
C4B68_RS31640	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C4B68_RS31645	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C4B68_RS31650	COG1187	pseudouridine synthase activity
C4B68_RS31705	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C4B68_RS31715	COG1160	GTP binding
C4B68_RS31745	COG1129	ABC transporter
C4B68_RS31765	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4B68_RS31775	COG0671	phosphoesterase, PA-phosphatase related
C4B68_RS31785	COG0477	Major facilitator Superfamily
C4B68_RS31790	COG1960	acyl-CoA dehydrogenase activity
C4B68_RS31795	COG1799	cell septum assembly
C4B68_RS31815	COG0330	HflC and HflK could
C4B68_RS31850	COG0587	DNA-directed DNA polymerase activity
C4B68_RS31855	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4B68_RS31855	COG0662	Cupin 2, conserved barrel domain protein
C4B68_RS31895	COG1725	Transcriptional regulator
C4B68_RS31920	COG0726	polysaccharide deacetylase
C4B68_RS31945	COG2755	lipolytic protein G-D-S-L family
C4B68_RS31970	COG1595	DNA-templated transcription, initiation
C4B68_RS31995	COG2188	Transcriptional regulator
C4B68_RS32000	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C4B68_RS32005	COG1309	transcriptional regulator
C4B68_RS32010	COG0243	molybdopterin cofactor binding
C4B68_RS32015	COG2851	Citrate transporter
C4B68_RS32045	COG0640	Transcriptional regulator
C4B68_RS32055	COG1960	acyl-CoA dehydrogenase activity
C4B68_RS32075	COG0789	Transcriptional regulator
C4B68_RS32105	COG3876	Protein conserved in bacteria
C4B68_RS32115	COG0318	PFAM AMP-dependent synthetase and ligase
C4B68_RS32140	COG2149	membrane
C4B68_RS32145	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C4B68_RS32155	COG3573	Dehydrogenase
C4B68_RS32190	COG3265	gluconokinase activity
C4B68_RS32195	COG2186	Transcriptional regulator
C4B68_RS32200	COG3012	SEC-C Motif Domain Protein
C4B68_RS32205	COG0308	aminopeptidase N
C4B68_RS32280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4B68_RS32310	COG0667	Aldo Keto reductase
C4B68_RS32315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4B68_RS32325	COG0598	Magnesium transport protein CorA
C4B68_RS32345	COG0215	cysteine-tRNA ligase activity
C4B68_RS32370	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C4B68_RS32375	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4B68_RS32380	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4B68_RS32385	COG1414	Transcriptional regulator
C4B68_RS32390	COG1410	methionine synthase
C4B68_RS32390	COG0646	methionine synthase
C4B68_RS32395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4B68_RS32410	COG4166	transmembrane transport
C4B68_RS32415	COG2197	response regulator
C4B68_RS32425	COG0517	IMP dehydrogenase activity
C4B68_RS32425	COG1994	Peptidase M50
C4B68_RS32450	COG1222	aaa ATPase
C4B68_RS32455	COG4122	O-methyltransferase activity
C4B68_RS32470	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C4B68_RS32475	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C4B68_RS32490	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C4B68_RS32505	COG2378	regulation of single-species biofilm formation
C4B68_RS32525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4B68_RS32530	COG0805	protein transport
C4B68_RS32565	COG1309	transcriptional regulator
C4B68_RS32595	COG0564	pseudouridine synthase activity
C4B68_RS32740	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4B68_RS32745	COG4175	Glycine betaine
C4B68_RS32745	COG3448	diguanylate cyclase activity
C4B68_RS32750	COG4176	ABC-type proline glycine betaine transport system permease component
C4B68_RS32790	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4B68_RS32800	COG0174	glutamine synthetase
C4B68_RS32805	COG1012	belongs to the aldehyde dehydrogenase family
C4B68_RS32860	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C4B68_RS32865	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C4B68_RS32870	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4B68_RS32875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4B68_RS32880	COG5002	protein histidine kinase activity
C4B68_RS32885	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4B68_RS32890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4B68_RS32890	COG0072	phenylalanine-tRNA ligase activity
C4B68_RS32925	COG0697	spore germination
C4B68_RS32965	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C4B68_RS32970	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C4B68_RS32975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4B68_RS32980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4B68_RS32985	COG1438	arginine binding
C4B68_RS33010	COG0137	argininosuccinate synthase activity
C4B68_RS33015	COG0165	Argininosuccinate lyase
C4B68_RS33030	COG0477	Major facilitator Superfamily
C4B68_RS33035	COG0318	PFAM AMP-dependent synthetase and ligase
C4B68_RS33035	COG0204	Acyl-transferase
C4B68_RS33040	COG0584	glycerophosphoryl diester phosphodiesterase
C4B68_RS33070	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4B68_RS33075	COG2011	ABC-type metal ion transport system permease component
C4B68_RS33080	COG1464	Belongs to the NlpA lipoprotein family
C4B68_RS33100	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C4B68_RS33105	COG1648	precorrin-2 dehydrogenase activity
C4B68_RS33105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4B68_RS33230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4B68_RS33245	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4B68_RS33250	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4B68_RS33275	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4B68_RS33280	COG1560	Kdo2-lipid A biosynthetic process
C4B68_RS33285	COG0438	transferase activity, transferring glycosyl groups
C4B68_RS33295	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C4B68_RS33300	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C4B68_RS33305	COG0217	transcriptional regulatory protein
C4B68_RS33310	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C4B68_RS33315	COG0632	four-way junction helicase activity
C4B68_RS33320	COG2255	four-way junction helicase activity
C4B68_RS33330	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C4B68_RS33335	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C4B68_RS33340	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4B68_RS33345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4B68_RS33350	COG1196	nuclear chromosome segregation
C4B68_RS33355	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C4B68_RS33365	COG0124	histidyl-tRNA synthetase
C4B68_RS33380	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C4B68_RS33395	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4B68_RS33400	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C4B68_RS33415	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4B68_RS33430	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C4B68_RS33435	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4B68_RS33445	COG0006	proline dipeptidase activity
C4B68_RS33450	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C4B68_RS33455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4B68_RS33465	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C4B68_RS33470	COG0540	Belongs to the ATCase OTCase family
C4B68_RS33475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4B68_RS33485	COG0505	Belongs to the CarA family
C4B68_RS33490	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4B68_RS33495	COG0167	dihydroorotate dehydrogenase activity
C4B68_RS33500	COG0284	orotidine-5'-phosphate decarboxylase activity
C4B68_RS33510	COG0194	GDP metabolic process
C4B68_RS33525	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4B68_RS33540	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4B68_RS33550	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4B68_RS33555	COG2390	Transcriptional regulator
C4B68_RS33585	COG2018	Roadblock/LC7 domain
C4B68_RS33595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4B68_RS33620	COG2233	PERMEase
C4B68_RS33625	COG2223	nitrite transmembrane transporter activity
C4B68_RS33630	COG1940	carbohydrate kinase activity
C4B68_RS33630	COG1846	Transcriptional regulator
C4B68_RS33645	COG3201	nicotinamide mononucleotide transporter
C4B68_RS33650	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4B68_RS33650	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4B68_RS33655	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4B68_RS33660	COG0140	phosphoribosyl-ATP diphosphatase activity
C4B68_RS33665	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C4B68_RS33765	COG0863	Belongs to the N(4) N(6)-methyltransferase family
C4B68_RS33915	COG2189	Belongs to the N(4) N(6)-methyltransferase family
C4B68_RS34020	COG2186	Transcriptional regulator
C4B68_RS34275	COG0438	transferase activity, transferring glycosyl groups
C4B68_RS34390	COG1309	transcriptional regulator
C4B68_RS34400	COG1960	acyl-CoA dehydrogenase activity
C4B68_RS34425	COG0463	Glycosyl transferase, family 2
C4B68_RS34440	COG2270	Major facilitator Superfamily
C4B68_RS34485	COG0438	transferase activity, transferring glycosyl groups
C4B68_RS34490	COG0438	transferase activity, transferring glycosyl groups
C4B68_RS34495	COG2755	lipolytic protein G-D-S-L family
C4B68_RS34560	COG2018	Roadblock/LC7 domain
C4B68_RS34580	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4B68_RS34585	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4B68_RS34595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4B68_RS34615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4B68_RS34635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4B68_RS34670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4B68_RS34710	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4B68_RS34720	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4B68_RS34720	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4B68_RS34745	COG0384	phenazine biosynthesis protein PhzF
C4B68_RS34755	COG1695	Transcriptional regulator
C4B68_RS34790	COG0697	spore germination
C4B68_RS34795	COG0583	DNA-binding transcription factor activity
C4B68_RS34840	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4B68_RS34860	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C4B68_RS34895	COG1028	Short-chain dehydrogenase reductase Sdr
C4B68_RS34905	COG1968	undecaprenyl-diphosphatase activity
C4B68_RS34930	COG0183	Belongs to the thiolase family
C4B68_RS34945	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4B68_RS34985	COG0110	maltose O-acetyltransferase activity
C4B68_RS35015	COG0640	Transcriptional regulator
C4B68_RS35020	COG2326	polyphosphate kinase activity
C4B68_RS35030	COG1832	CoA-binding protein
C4B68_RS35055	COG1739	Uncharacterized protein family UPF0029
C4B68_RS35065	COG3237	CsbD-like
C4B68_RS35070	COG0420	3'-5' exonuclease activity
C4B68_RS35075	COG0419	ATPase involved in DNA repair
C4B68_RS35080	COG1522	sequence-specific DNA binding
C4B68_RS35105	COG0626	cystathionine gamma-synthase activity
C4B68_RS35130	COG2188	Transcriptional regulator
C4B68_RS35135	COG1940	carbohydrate kinase activity
C4B68_RS35140	COG2197	response regulator
C4B68_RS35145	COG4585	Histidine kinase
C4B68_RS35160	COG3663	DNA glycosylase
C4B68_RS35165	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C4B68_RS35175	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4B68_RS35210	COG0456	acetyltransferase
C4B68_RS35220	COG0577	efflux transmembrane transporter activity
C4B68_RS35220	COG1136	(ABC) transporter
C4B68_RS35225	COG1136	(ABC) transporter
C4B68_RS35225	COG0577	efflux transmembrane transporter activity
C4B68_RS35250	COG1175	transmembrane transport
C4B68_RS35255	COG0395	ABC-type sugar transport system, permease component
C4B68_RS35265	COG0673	inositol 2-dehydrogenase activity
C4B68_RS35270	COG0366	Alpha amylase catalytic
C4B68_RS35275	COG2226	methyltransferase
C4B68_RS35280	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C4B68_RS35285	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C4B68_RS35290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4B68_RS35330	COG0740	serine-type endopeptidase activity
C4B68_RS35350	COG0831	urea catabolic process
C4B68_RS35355	COG0832	Belongs to the urease beta subunit family
C4B68_RS35360	COG0804	urea catabolic process
C4B68_RS35365	COG0830	nickel cation binding
C4B68_RS35370	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C4B68_RS35375	COG0829	nickel cation binding
C4B68_RS35380	COG3979	chitinase
C4B68_RS35400	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4B68_RS35405	COG1834	amidinotransferase
C4B68_RS35415	COG3279	Response regulator of the LytR AlgR family
C4B68_RS35425	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4B68_RS35430	COG3275	phosphorelay sensor kinase activity
C4B68_RS35455	COG0205	6-phosphofructokinase activity
C4B68_RS35460	COG3442	glutamine amidotransferase
C4B68_RS35470	COG0242	peptide deformylase activity
C4B68_RS35480	COG1960	acyl-CoA dehydrogenase activity
C4B68_RS35490	COG2124	cytochrome p450
C4B68_RS35495	COG3424	synthase
C4B68_RS35510	COG1012	belongs to the aldehyde dehydrogenase family
C4B68_RS35520	COG1793	dna ligase
C4B68_RS35525	COG3118	belongs to the thioredoxin family
C4B68_RS35525	COG0492	ferredoxin-NADP+ reductase activity
C4B68_RS35540	COG1960	acyl-CoA dehydrogenase activity
C4B68_RS35545	COG1960	acyl-CoA dehydrogenase activity
C4B68_RS35590	COG1414	Transcriptional regulator
C4B68_RS35595	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4B68_RS35615	COG1940	carbohydrate kinase activity
C4B68_RS35615	COG1846	Transcriptional regulator
C4B68_RS35625	COG2115	Belongs to the xylose isomerase family
C4B68_RS35640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4B68_RS35645	COG3239	Fatty acid desaturase
C4B68_RS35700	COG2018	Roadblock/LC7 domain
C4B68_RS35715	COG1946	Acyl-CoA thioesterase
C4B68_RS35730	COG0254	rRNA binding
C4B68_RS35740	COG1132	(ABC) transporter
C4B68_RS35765	COG1132	(ABC) transporter
C4B68_RS35775	COG2072	flavoprotein involved in K transport
C4B68_RS35790	COG0432	Pfam Uncharacterised protein family UPF0047
C4B68_RS35800	COG1278	Cold shock
C4B68_RS35805	COG0513	Belongs to the DEAD box helicase family
C4B68_RS35810	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C4B68_RS35835	COG2080	2 iron, 2 sulfur cluster binding
C4B68_RS35840	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C4B68_RS35845	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4B68_RS35850	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4B68_RS35850	COG3608	succinylglutamate desuccinylase aspartoacylase
C4B68_RS35875	COG2208	phosphoserine phosphatase activity
C4B68_RS35875	COG2770	Histidine kinase
C4B68_RS35890	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
C4B68_RS35895	COG2706	6-phosphogluconolactonase activity
C4B68_RS35910	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4B68_RS35950	COG0640	Transcriptional regulator
C4B68_RS35975	COG1309	transcriptional regulator
C4B68_RS35990	COG0671	phosphoesterase, PA-phosphatase related
C4B68_RS36035	COG0584	glycerophosphoryl diester phosphodiesterase
C4B68_RS36040	COG0657	acetylesterase activity
C4B68_RS36070	COG0204	Acyl-transferase
C4B68_RS36095	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4B68_RS36130	COG0494	nUDIX hydrolase
C4B68_RS36140	COG0445	tRNA wobble uridine modification
C4B68_RS36155	COG4585	Histidine kinase
C4B68_RS36160	COG2197	response regulator
C4B68_RS36200	COG1349	DNA-binding transcription factor activity
C4B68_RS36205	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4B68_RS36210	COG0191	fructose-bisphosphate aldolase activity
C4B68_RS36215	COG2813	Specifically methylates the guanine in position
C4B68_RS36225	COG1940	carbohydrate kinase activity
C4B68_RS36250	COG1136	(ABC) transporter
C4B68_RS36255	COG1136	(ABC) transporter
C4B68_RS36255	COG0577	efflux transmembrane transporter activity
C4B68_RS36280	COG1349	DNA-binding transcription factor activity
C4B68_RS36315	COG1215	transferase activity, transferring glycosyl groups
C4B68_RS36320	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4B68_RS36340	COG1051	belongs to the nudix hydrolase family
C4B68_RS36345	COG1028	Short-chain dehydrogenase reductase Sdr
C4B68_RS36380	COG2770	Histidine kinase
C4B68_RS36380	COG2208	phosphoserine phosphatase activity
C4B68_RS36400	COG1309	transcriptional regulator
C4B68_RS36415	COG2080	2 iron, 2 sulfur cluster binding
C4B68_RS36420	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C4B68_RS36425	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4B68_RS36480	COG1960	acyl-CoA dehydrogenase activity
C4B68_RS36505	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4B68_RS36505	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4B68_RS36525	COG2423	ornithine cyclodeaminase activity
C4B68_RS36550	COG0701	Predicted permease
C4B68_RS36565	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4B68_RS36585	COG1968	undecaprenyl-diphosphatase activity
C4B68_RS36600	COG1027	Aspartate ammonia-lyase
C4B68_RS36620	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C4B68_RS36635	COG0366	Alpha amylase catalytic
C4B68_RS36640	COG2226	methyltransferase
C4B68_RS36660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C4B68_RS36685	COG3458	cephalosporin-C deacetylase activity
C4B68_RS36705	COG2890	protein-(glutamine-N5) methyltransferase activity
C4B68_RS36710	COG1902	pentaerythritol trinitrate reductase activity
C4B68_RS36710	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4B68_RS36735	COG1461	Dihydroxyacetone kinase
C4B68_RS36740	COG2376	Dihydroxyacetone kinase
C4B68_RS36765	COG2824	Alkylphosphonate utilization operon protein PhnA
C4B68_RS36775	COG0659	secondary active sulfate transmembrane transporter activity
C4B68_RS36855	COG0673	inositol 2-dehydrogenase activity
C4B68_RS36865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4B68_RS36870	COG0019	diaminopimelate decarboxylase activity
C4B68_RS36885	COG0747	negative chemotaxis
C4B68_RS36895	COG4171	peptide transport system, permease
C4B68_RS36915	COG1960	acyl-CoA dehydrogenase activity
C4B68_RS36945	COG0515	serine threonine protein kinase
C4B68_RS36990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C4B68_RS36995	COG2070	2-Nitropropane dioxygenase
C4B68_RS37005	COG2366	antibiotic biosynthetic process
C4B68_RS37010	COG0318	PFAM AMP-dependent synthetase and ligase
C4B68_RS37080	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C4B68_RS37080	COG0515	serine threonine protein kinase
C4B68_RS37085	COG0297	glycogen (starch) synthase activity
C4B68_RS37095	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C4B68_RS37095	COG1672	PFAM Archaeal ATPase
C4B68_RS37145	COG0673	inositol 2-dehydrogenase activity
C4B68_RS37160	COG2235	arginine
C4B68_RS37190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4B68_RS37195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4B68_RS37280	COG0667	Aldo Keto reductase
C4B68_RS37285	COG0412	Dienelactone hydrolase
C4B68_RS37290	COG0346	lactoylglutathione lyase activity
C4B68_RS37295	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4B68_RS37305	COG0583	DNA-binding transcription factor activity
C4B68_RS37310	COG0667	Aldo Keto reductase
C4B68_RS37345	COG2318	DinB family
C4B68_RS37390	COG1937	Protein conserved in bacteria
C4B68_RS37440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4B68_RS37445	COG4569	acetaldehyde dehydrogenase (acetylating) activity
C4B68_RS37455	COG1414	Transcriptional regulator
C4B68_RS37465	COG2132	Multicopper oxidase
C4B68_RS37485	COG0596	Alpha beta hydrolase
C4B68_RS37515	COG0328	RNA-DNA hybrid ribonuclease activity
C4B68_RS37600	COG0494	nUDIX hydrolase
C4B68_RS37635	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4B68_RS37640	COG3281	Trehalose synthase
C4B68_RS37650	COG0366	Alpha amylase catalytic
C4B68_RS37765	COG3290	protein histidine kinase activity
C4B68_RS37775	COG0009	L-threonylcarbamoyladenylate synthase
C4B68_RS37785	COG2226	methyltransferase
C4B68_RS37790	COG0789	Transcriptional regulator
C4B68_RS37800	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4B68_RS37935	COG1595	DNA-templated transcription, initiation
C4B68_RS37940	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4B68_RS37960	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4B68_RS37965	COG4106	trans-aconitate 2-methyltransferase activity
C4B68_RS37970	COG1653	transport
C4B68_RS38000	COG0596	Alpha beta hydrolase
C4B68_RS38015	COG0673	inositol 2-dehydrogenase activity
C4B68_RS38025	COG0395	ABC-type sugar transport system, permease component
C4B68_RS38030	COG1175	transmembrane transport
C4B68_RS38065	COG1764	response to oxidative stress
C4B68_RS38070	COG1595	DNA-templated transcription, initiation
C4B68_RS38080	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C4B68_RS38105	COG0318	PFAM AMP-dependent synthetase and ligase
C4B68_RS38125	COG1653	transport
C4B68_RS38130	COG1175	transmembrane transport
C4B68_RS38135	COG0395	ABC-type sugar transport system, permease component
C4B68_RS38150	COG2186	Transcriptional regulator
C4B68_RS38155	COG4948	Mandelate Racemase Muconate Lactonizing
C4B68_RS38165	COG0800	Aldolase
C4B68_RS38200	COG1846	Transcriptional regulator
C4B68_RS38220	COG1595	DNA-templated transcription, initiation
C4B68_RS38260	COG1053	succinate dehydrogenase
C4B68_RS38290	COG1960	acyl-CoA dehydrogenase activity
C4B68_RS38320	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4B68_RS38330	COG1028	Short-chain dehydrogenase reductase Sdr
C4B68_RS38340	COG1024	Enoyl-CoA hydratase
C4B68_RS38345	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4B68_RS38355	COG0477	Major facilitator Superfamily
C4B68_RS38360	COG1396	sequence-specific DNA binding
C4B68_RS38365	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4B68_RS38365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4B68_RS38370	COG1028	Short-chain dehydrogenase reductase Sdr
C4B68_RS38420	COG0494	nUDIX hydrolase
C4B68_RS38480	COG2197	response regulator
C4B68_RS38485	COG4585	Histidine kinase
C4B68_RS38515	COG2259	Doxx family
C4B68_RS38525	COG2318	DinB family
C4B68_RS38560	COG2986	histidine ammonia-lyase
C4B68_RS38565	COG0318	PFAM AMP-dependent synthetase and ligase
C4B68_RS38575	COG2124	cytochrome p450
C4B68_RS38620	COG3629	intracellular signal transduction
C4B68_RS38620	COG3903	Transcriptional regulator
C4B68_RS38645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4B68_RS38650	COG0395	ABC-type sugar transport system, permease component
C4B68_RS38675	COG2755	lipolytic protein G-D-S-L family
C4B68_RS38730	COG0745	RESPONSE REGULATOR receiver
C4B68_RS38755	COG1595	DNA-templated transcription, initiation
C4B68_RS38760	COG2197	response regulator
C4B68_RS38775	COG1024	Enoyl-CoA hydratase
C4B68_RS38785	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4B68_RS38790	COG1960	acyl-CoA dehydrogenase activity
C4B68_RS38800	COG1335	isochorismatase
C4B68_RS38805	COG2197	response regulator
C4B68_RS38810	COG1028	Short-chain dehydrogenase reductase Sdr
C4B68_RS38815	COG0583	DNA-binding transcription factor activity
C4B68_RS38825	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
C4B68_RS38850	COG0395	ABC-type sugar transport system, permease component
C4B68_RS38865	COG1063	alcohol dehydrogenase
C4B68_RS38870	COG1082	Xylose isomerase domain protein TIM barrel
C4B68_RS38875	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C4B68_RS38930	COG1609	Transcriptional regulator
C4B68_RS38935	COG1653	transport
C4B68_RS38940	COG1175	transmembrane transport
C4B68_RS38945	COG0395	ABC-type sugar transport system, permease component
C4B68_RS38955	COG1501	Belongs to the glycosyl hydrolase 31 family
C4B68_RS39015	COG1404	Belongs to the peptidase S8 family
C4B68_RS39055	COG3251	PFAM MbtH domain protein
C4B68_RS39070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4B68_RS39090	COG3483	tryptophan 2,3-dioxygenase activity
C4B68_RS39145	COG3547	Transposase (IS116 IS110 IS902 family)
C4B68_RS39150	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4B68_RS39175	COG1024	Enoyl-CoA hydratase
C4B68_RS39205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4B68_RS39210	COG0805	protein transport
C4B68_RS39220	COG0596	Alpha beta hydrolase
C4B68_RS39250	COG2801	Transposase and inactivated derivatives
C4B68_RS39300	COG3655	Transcriptional regulator
C4B68_RS39370	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C4B68_RS39415	COG2226	methyltransferase
C4B68_RS39515	COG1902	pentaerythritol trinitrate reductase activity
C4B68_RS39545	COG0515	serine threonine protein kinase
C4B68_RS39550	COG2255	four-way junction helicase activity
C4B68_RS39565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4B68_RS39585	COG0252	asparaginase activity
C4B68_RS39615	COG2084	Dehydrogenase
C4B68_RS39620	COG1137	ATPase activity
C4B68_RS39645	COG1609	Transcriptional regulator
C4B68_RS39665	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C4B68_RS39730	COG4974	Belongs to the 'phage' integrase family
C4B68_RS39790	COG0251	oxidation-reduction process
C4B68_RS39815	COG0653	protein targeting
C4B68_RS39975	COG0546	phosphoglycolate phosphatase activity
C4B68_RS39980	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C4B68_RS40005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4B68_RS40010	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4B68_RS40110	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C4B68_RS40400	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C4B68_RS40545	COG1793	dna ligase
C4B68_RS40655	COG1475	DNA binding
C4B68_RS40670	COG1660	Displays ATPase and GTPase activities
C4B68_RS40680	COG0592	DNA-directed DNA polymerase activity
C4B68_RS40870	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C4B68_RS40875	COG0515	serine threonine protein kinase
C4B68_RS40875	COG2815	serine threonine protein kinase