locus-tag	class	description
KME66_RS00100	COG4221	oxidoreductase activity
KME66_RS00460	COG4977	sequence-specific DNA binding
KME66_RS00550	COG1070	Carbohydrate kinase
KME66_RS00565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KME66_RS00580	COG1595	DNA-templated transcription, initiation
KME66_RS00590	COG2226	methyltransferase
KME66_RS00605	COG0586	Pfam SNARE associated Golgi protein
KME66_RS00650	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KME66_RS00665	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
KME66_RS00670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KME66_RS00695	COG3552	Protein containing von Willebrand factor type A (VWA) domain
KME66_RS00700	COG0714	Associated with various cellular activities
KME66_RS00710	COG1028	Short-chain dehydrogenase reductase Sdr
KME66_RS00715	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KME66_RS00730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KME66_RS00735	COG0395	ABC-type sugar transport system, permease component
KME66_RS00750	COG1609	Transcriptional regulator
KME66_RS00760	COG2318	DinB family
KME66_RS00800	COG0009	L-threonylcarbamoyladenylate synthase
KME66_RS00820	COG0488	(ABC) transporter
KME66_RS00855	COG2340	Cysteine-rich secretory protein family
KME66_RS00870	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KME66_RS00875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KME66_RS00895	COG1024	Enoyl-CoA hydratase
KME66_RS00925	COG2018	Roadblock/LC7 domain
KME66_RS00940	COG0789	Transcriptional regulator
KME66_RS00960	COG0640	Transcriptional regulator
KME66_RS00965	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KME66_RS00995	COG3547	Transposase (IS116 IS110 IS902 family)
KME66_RS01005	COG3239	Fatty acid desaturase
KME66_RS01010	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KME66_RS01030	COG1012	belongs to the aldehyde dehydrogenase family
KME66_RS01045	COG0672	)-iron permease
KME66_RS01050	COG2837	iron assimilation
KME66_RS01060	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KME66_RS01065	COG0589	response to stress
KME66_RS01070	COG0589	response to stress
KME66_RS01080	COG4651	solute:proton antiporter activity
KME66_RS01080	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KME66_RS01120	COG0667	Aldo Keto reductase
KME66_RS01135	COG1408	metallophosphoesterase
KME66_RS01145	COG1960	acyl-CoA dehydrogenase activity
KME66_RS01165	COG1349	DNA-binding transcription factor activity
KME66_RS01175	COG1175	transmembrane transport
KME66_RS01185	COG1063	alcohol dehydrogenase
KME66_RS01205	COG4044	May play a role in the intracellular transport of hydrophobic ligands
KME66_RS01215	COG2375	cellular response to nickel ion
KME66_RS01225	COG0309	Hydrogenase expression formation protein (HypE)
KME66_RS01230	COG0409	Hydrogenase expression formation protein
KME66_RS01235	COG0298	carbon dioxide binding
KME66_RS01240	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
KME66_RS01250	COG0375	protein maturation
KME66_RS01285	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
KME66_RS01295	COG0693	protein deglycase activity
KME66_RS01300	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
KME66_RS01310	COG1278	Cold shock
KME66_RS01415	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KME66_RS01415	COG1796	DNA polymerase
KME66_RS01515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KME66_RS01520	COG0601	transmembrane transport
KME66_RS01530	COG1960	acyl-CoA dehydrogenase activity
KME66_RS01535	COG1960	acyl-CoA dehydrogenase activity
KME66_RS01555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KME66_RS01580	COG0438	transferase activity, transferring glycosyl groups
KME66_RS01600	COG0726	polysaccharide deacetylase
KME66_RS01605	COG0438	transferase activity, transferring glycosyl groups
KME66_RS01625	COG2304	oxidoreductase activity
KME66_RS01685	COG1120	ATPase activity
KME66_RS01690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KME66_RS01695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KME66_RS01710	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KME66_RS01715	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KME66_RS01720	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KME66_RS01725	COG0254	rRNA binding
KME66_RS01735	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KME66_RS01740	COG0477	Major facilitator Superfamily
KME66_RS01750	COG1120	ATPase activity
KME66_RS01790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KME66_RS01795	COG4569	acetaldehyde dehydrogenase (acetylating) activity
KME66_RS01800	COG3971	2-oxopent-4-enoate hydratase activity
KME66_RS01805	COG1414	Transcriptional regulator
KME66_RS01810	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KME66_RS01850	COG0477	Major facilitator Superfamily
KME66_RS01855	COG0515	serine threonine protein kinase
KME66_RS01900	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KME66_RS01925	COG1228	amidohydrolase
KME66_RS01935	COG1834	amidinotransferase
KME66_RS01945	COG1357	PFAM Pentapeptide repeats (8 copies)
KME66_RS01965	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KME66_RS01975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KME66_RS01980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KME66_RS01990	COG1609	Transcriptional regulator
KME66_RS02010	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KME66_RS02015	COG0121	glutamine amidotransferase
KME66_RS02020	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
KME66_RS02035	COG2182	Extracellular solute-binding protein
KME66_RS02040	COG3360	Dodecin
KME66_RS02050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KME66_RS02070	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KME66_RS02075	COG1053	succinate dehydrogenase
KME66_RS02085	COG0583	DNA-binding transcription factor activity
KME66_RS02140	COG2843	Capsule synthesis protein
KME66_RS02160	COG3275	phosphorelay sensor kinase activity
KME66_RS02165	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KME66_RS02185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KME66_RS02225	COG1191	sigma factor activity
KME66_RS02230	COG2201	protein-glutamate methylesterase activity
KME66_RS02235	COG4251	negative regulation of phosphorylation
KME66_RS02240	COG0784	Response regulator, receiver
KME66_RS02255	COG1733	regulation of RNA biosynthetic process
KME66_RS02260	COG2208	phosphoserine phosphatase activity
KME66_RS02300	COG1940	carbohydrate kinase activity
KME66_RS02310	COG1175	transmembrane transport
KME66_RS02315	COG0395	ABC-type sugar transport system, permease component
KME66_RS02325	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KME66_RS02360	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KME66_RS02365	COG2837	iron assimilation
KME66_RS02375	COG0019	diaminopimelate decarboxylase activity
KME66_RS02380	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KME66_RS02390	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KME66_RS02425	COG0656	L-ascorbic acid biosynthetic process
KME66_RS02430	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KME66_RS02440	COG2208	phosphoserine phosphatase activity
KME66_RS02440	COG2770	Histidine kinase
KME66_RS02460	COG0659	secondary active sulfate transmembrane transporter activity
KME66_RS02465	COG0789	Transcriptional regulator
KME66_RS02470	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
KME66_RS02475	COG1937	Protein conserved in bacteria
KME66_RS02490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KME66_RS02490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KME66_RS02500	COG2124	cytochrome p450
KME66_RS02505	COG2130	NADP-dependent
KME66_RS02510	COG1233	COG1233 Phytoene dehydrogenase and related
KME66_RS02555	COG1846	Transcriptional regulator
KME66_RS02560	COG2409	Drug exporters of the RND superfamily
KME66_RS02570	COG0446	pyridine nucleotide-disulphide oxidoreductase
KME66_RS02570	COG1902	pentaerythritol trinitrate reductase activity
KME66_RS02595	COG1028	Short-chain dehydrogenase reductase Sdr
KME66_RS02605	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KME66_RS02635	COG1132	(ABC) transporter
KME66_RS02640	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KME66_RS02675	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KME66_RS02685	COG2197	response regulator
KME66_RS02690	COG1012	belongs to the aldehyde dehydrogenase family
KME66_RS02770	COG3511	phospholipase C
KME66_RS02775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KME66_RS02820	COG3959	Transketolase, thiamine diphosphate binding domain
KME66_RS02825	COG3958	Transketolase
KME66_RS02895	COG3467	pyridoxamine 5'-phosphate
KME66_RS02935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KME66_RS02945	COG2755	lipolytic protein G-D-S-L family
KME66_RS02985	COG1657	PFAM Prenyltransferase squalene oxidase
KME66_RS02995	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KME66_RS03005	COG1562	ergosterol biosynthetic process
KME66_RS03010	COG1388	LysM domain
KME66_RS03010	COG1134	teichoic acid transport
KME66_RS03030	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KME66_RS03060	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
KME66_RS03075	COG1024	Enoyl-CoA hydratase
KME66_RS03085	COG4977	sequence-specific DNA binding
KME66_RS03100	COG2226	methyltransferase
KME66_RS03105	COG0488	(ABC) transporter
KME66_RS03120	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KME66_RS03135	COG0789	Transcriptional regulator
KME66_RS03140	COG1250	3-hydroxyacyl-CoA dehydrogenase
KME66_RS03140	COG1024	Enoyl-CoA hydratase
KME66_RS03145	COG0183	Belongs to the thiolase family
KME66_RS03150	COG1960	acyl-CoA dehydrogenase activity
KME66_RS03155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KME66_RS03160	COG3268	Saccharopine dehydrogenase
KME66_RS03175	COG1515	deoxyribonuclease V activity
KME66_RS03200	COG0488	(ABC) transporter
KME66_RS03250	COG1793	dna ligase
KME66_RS03255	COG2326	polyphosphate kinase activity
KME66_RS03290	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KME66_RS03315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KME66_RS03360	COG1960	acyl-CoA dehydrogenase activity
KME66_RS03390	COG3012	SEC-C Motif Domain Protein
KME66_RS03420	COG1486	melibiose metabolic process
KME66_RS03450	COG1846	Transcriptional regulator
KME66_RS03475	COG1940	carbohydrate kinase activity
KME66_RS03515	COG4176	ABC-type proline glycine betaine transport system permease component
KME66_RS03520	COG4175	Glycine betaine
KME66_RS03520	COG0517	IMP dehydrogenase activity
KME66_RS03530	COG1012	belongs to the aldehyde dehydrogenase family
KME66_RS03555	COG0745	RESPONSE REGULATOR receiver
KME66_RS03560	COG5002	protein histidine kinase activity
KME66_RS03575	COG3568	Endonuclease Exonuclease Phosphatase
KME66_RS03585	COG1869	D-ribose catabolic process
KME66_RS03590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KME66_RS03600	COG1129	ABC transporter
KME66_RS03630	COG2264	protein methyltransferase activity
KME66_RS03705	COG0673	inositol 2-dehydrogenase activity
KME66_RS03710	COG1879	ABC-type sugar transport system periplasmic component
KME66_RS03715	COG1172	Belongs to the binding-protein-dependent transport system permease family
KME66_RS03720	COG1129	ABC transporter
KME66_RS03725	COG1940	carbohydrate kinase activity
KME66_RS03730	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KME66_RS03735	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KME66_RS03760	COG0656	L-ascorbic acid biosynthetic process
KME66_RS03770	COG4106	trans-aconitate 2-methyltransferase activity
KME66_RS03780	COG0702	epimerase
KME66_RS03790	COG2154	pterin-4-alpha-carbinolamine dehydratase
KME66_RS03800	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KME66_RS03800	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KME66_RS03810	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KME66_RS03870	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
KME66_RS03890	COG0142	geranyltranstransferase activity
KME66_RS03905	COG1619	proteins homologs of microcin C7 resistance protein MccF
KME66_RS03915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KME66_RS03920	COG2362	D-Aminopeptidase
KME66_RS03940	COG0667	Aldo Keto reductase
KME66_RS03945	COG0583	DNA-binding transcription factor activity
KME66_RS03965	COG1012	belongs to the aldehyde dehydrogenase family
KME66_RS03975	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KME66_RS03980	COG0596	Alpha beta hydrolase
KME66_RS03990	COG1250	3-hydroxyacyl-CoA dehydrogenase
KME66_RS04010	COG0604	alcohol dehydrogenase
KME66_RS04015	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KME66_RS04015	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KME66_RS04020	COG2301	Belongs to the HpcH HpaI aldolase family
KME66_RS04030	COG1960	acyl-CoA dehydrogenase activity
KME66_RS04035	COG0688	phosphatidylethanolamine metabolic process
KME66_RS04045	COG0488	(ABC) transporter
KME66_RS04055	COG0559	Belongs to the binding-protein-dependent transport system permease family
KME66_RS04060	COG0559	Belongs to the binding-protein-dependent transport system permease family
KME66_RS04080	COG1929	Belongs to the glycerate kinase type-1 family
KME66_RS04115	COG1028	Short-chain dehydrogenase reductase Sdr
KME66_RS04140	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KME66_RS04205	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KME66_RS04225	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KME66_RS04245	COG0095	Lipoate-protein ligase
KME66_RS04265	COG2838	Isocitrate dehydrogenase
KME66_RS04270	COG2205	protein histidine kinase activity
KME66_RS04280	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KME66_RS04305	COG1953	Uracil, thiamine, allantoin
KME66_RS04315	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KME66_RS04355	COG0405	Gamma-glutamyltransferase
KME66_RS04375	COG0765	amino acid transport
KME66_RS04380	COG0765	amino acid transport
KME66_RS04385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KME66_RS04390	COG1126	abc transporter atp-binding protein
KME66_RS04400	COG1028	Short-chain dehydrogenase reductase Sdr
KME66_RS04415	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KME66_RS04420	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KME66_RS04455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KME66_RS04465	COG1940	carbohydrate kinase activity
KME66_RS04470	COG1129	ABC transporter
KME66_RS04480	COG1879	ABC-type sugar transport system periplasmic component
KME66_RS04485	COG2188	Transcriptional regulator
KME66_RS04490	COG0673	inositol 2-dehydrogenase activity
KME66_RS04530	COG1028	Short-chain dehydrogenase reductase Sdr
KME66_RS04535	COG0656	L-ascorbic acid biosynthetic process
KME66_RS04540	COG4266	Belongs to the allantoicase family
KME66_RS04545	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KME66_RS04550	COG1414	Transcriptional regulator
KME66_RS04555	COG1136	(ABC) transporter
KME66_RS04570	COG2197	response regulator
KME66_RS04585	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KME66_RS04605	COG2233	PERMEase
KME66_RS04615	COG2233	PERMEase
KME66_RS04625	COG2351	hydroxyisourate hydrolase activity
KME66_RS04645	COG2188	Transcriptional regulator
KME66_RS04655	COG1175	transmembrane transport
KME66_RS04660	COG0395	ABC-type sugar transport system, permease component
KME66_RS04670	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KME66_RS04675	COG3622	Belongs to the hyi family
KME66_RS04680	COG2084	Dehydrogenase
KME66_RS04685	COG0753	catalase activity
KME66_RS04690	COG3960	tartronate-semialdehyde synthase activity
KME66_RS04710	COG0318	PFAM AMP-dependent synthetase and ligase
KME66_RS04715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KME66_RS04720	COG2197	response regulator
KME66_RS04735	COG0435	Glutathione S-transferase
KME66_RS04765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KME66_RS04795	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
KME66_RS04795	COG3608	succinylglutamate desuccinylase aspartoacylase
KME66_RS04800	COG2252	PERMEase
KME66_RS04805	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KME66_RS04830	COG1802	Transcriptional regulator
KME66_RS04855	COG0028	Belongs to the TPP enzyme family
KME66_RS04865	COG1404	Belongs to the peptidase S8 family
KME66_RS04885	COG1162	GTPase activity
KME66_RS04935	COG0183	Belongs to the thiolase family
KME66_RS04940	COG0583	DNA-binding transcription factor activity
KME66_RS04945	COG1250	3-hydroxyacyl-CoA dehydrogenase
KME66_RS04965	COG1960	acyl-CoA dehydrogenase activity
KME66_RS04990	COG0175	sulfate reduction
KME66_RS04995	COG0529	Catalyzes the synthesis of activated sulfate
KME66_RS05015	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
KME66_RS05020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KME66_RS05105	COG2723	6-phospho-beta-galactosidase activity
KME66_RS05120	COG1072	(Pantothenic acid kinase))
KME66_RS05125	COG0346	lactoylglutathione lyase activity
KME66_RS05135	COG0583	DNA-binding transcription factor activity
KME66_RS05140	COG0156	8-amino-7-oxononanoate synthase activity
KME66_RS05145	COG1063	alcohol dehydrogenase
KME66_RS05155	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KME66_RS05155	COG0515	serine threonine protein kinase
KME66_RS05250	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KME66_RS05255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KME66_RS05325	COG3253	May function as heme-dependent peroxidase
KME66_RS05330	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KME66_RS05340	COG0446	pyridine nucleotide-disulphide oxidoreductase
KME66_RS05345	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KME66_RS05365	COG0183	Belongs to the thiolase family
KME66_RS05370	COG1024	Enoyl-CoA hydratase
KME66_RS05370	COG1250	3-hydroxyacyl-CoA dehydrogenase
KME66_RS05380	COG2755	lipolytic protein G-D-S-L family
KME66_RS05385	COG1216	Glycosyl transferase, family 2
KME66_RS05445	COG1505	serine-type exopeptidase activity
KME66_RS05450	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KME66_RS05455	COG4214	carbohydrate transport
KME66_RS05465	COG4213	ABC transporter substrate-binding protein
KME66_RS05470	COG1940	carbohydrate kinase activity
KME66_RS05475	COG0395	ABC-type sugar transport system, permease component
KME66_RS05480	COG1175	transmembrane transport
KME66_RS05485	COG1653	transport
KME66_RS05495	COG0588	phosphoglycerate mutase activity
KME66_RS05515	COG0492	ferredoxin-NADP+ reductase activity
KME66_RS05520	COG1309	transcriptional regulator
KME66_RS05555	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KME66_RS05560	COG1742	UPF0060 membrane protein
KME66_RS05580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KME66_RS05610	COG2311	Membrane
KME66_RS05640	COG0438	transferase activity, transferring glycosyl groups
KME66_RS05650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KME66_RS05655	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KME66_RS05675	COG1012	belongs to the aldehyde dehydrogenase family
KME66_RS05685	COG1366	Belongs to the anti-sigma-factor antagonist family
KME66_RS05685	COG2172	sigma factor antagonist activity
KME66_RS05685	COG2208	phosphoserine phosphatase activity
KME66_RS05695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KME66_RS05700	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
KME66_RS05735	COG0489	protein tyrosine kinase activity
KME66_RS05740	COG0297	glycogen (starch) synthase activity
KME66_RS05755	COG1320	monovalent cation:proton antiporter activity
KME66_RS05770	COG0651	ATP synthesis coupled electron transport
KME66_RS05775	COG1006	Multisubunit Na H antiporter MnhC subunit
KME66_RS05780	COG2111	Na H antiporter
KME66_RS05780	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KME66_RS05830	COG1024	Enoyl-CoA hydratase
KME66_RS05840	COG0531	amino acid
KME66_RS05845	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KME66_RS05855	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KME66_RS05865	COG2040	homocysteine
KME66_RS05885	COG1799	cell septum assembly
KME66_RS05890	COG1349	DNA-binding transcription factor activity
KME66_RS05895	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KME66_RS05900	COG0586	Pfam SNARE associated Golgi protein
KME66_RS05910	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KME66_RS05915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KME66_RS05940	COG3046	protein related to deoxyribodipyrimidine photolyase
KME66_RS05945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KME66_RS05950	COG1280	lysine exporter protein (LysE YggA)
KME66_RS05960	COG3291	Pkd domain containing protein
KME66_RS05965	COG4608	Belongs to the ABC transporter superfamily
KME66_RS05975	COG0601	transmembrane transport
KME66_RS05980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KME66_RS05990	COG0006	proline dipeptidase activity
KME66_RS06020	COG0604	alcohol dehydrogenase
KME66_RS06020	COG3321	synthase
KME66_RS06020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KME66_RS06020	COG4221	oxidoreductase activity
KME66_RS06035	COG1802	Transcriptional regulator
KME66_RS06040	COG2423	ornithine cyclodeaminase activity
KME66_RS06050	COG3938	Belongs to the proline racemase family
KME66_RS06060	COG0446	pyridine nucleotide-disulphide oxidoreductase
KME66_RS06080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KME66_RS06085	COG0640	Transcriptional regulator
KME66_RS06120	COG1007	ATP synthesis coupled electron transport
KME66_RS06130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KME66_RS06135	COG0713	ATP synthesis coupled electron transport
KME66_RS06145	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KME66_RS06155	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KME66_RS06160	COG1309	transcriptional regulator
KME66_RS06175	COG4335	DNA alkylation repair
KME66_RS06200	COG1309	transcriptional regulator
KME66_RS06240	COG3547	Transposase (IS116 IS110 IS902 family)
KME66_RS06245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KME66_RS06250	COG0531	amino acid
KME66_RS06255	COG0569	domain protein
KME66_RS06285	COG4591	ABC-type transport system involved in lipoprotein release permease component
KME66_RS06285	COG1136	(ABC) transporter
KME66_RS06295	COG0756	dUTP diphosphatase activity
KME66_RS06320	COG2205	protein histidine kinase activity
KME66_RS06325	COG0745	RESPONSE REGULATOR receiver
KME66_RS06340	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KME66_RS06375	COG1278	Cold shock
KME66_RS06380	COG1435	thymidine kinase activity
KME66_RS06395	COG0045	succinate-CoA ligase (ADP-forming) activity
KME66_RS06395	COG1042	CoA-binding domain protein
KME66_RS06395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KME66_RS06400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KME66_RS06405	COG1802	Transcriptional regulator
KME66_RS06420	COG0612	Peptidase, M16
KME66_RS06425	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KME66_RS06435	COG0372	Belongs to the citrate synthase family
KME66_RS06440	COG0372	Belongs to the citrate synthase family
KME66_RS06450	COG3290	protein histidine kinase activity
KME66_RS06455	COG4565	transcriptional regulatory protein
KME66_RS06460	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KME66_RS06485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KME66_RS06490	COG2186	Transcriptional regulator
KME66_RS06495	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KME66_RS06525	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KME66_RS06565	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KME66_RS06570	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KME66_RS06575	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KME66_RS06610	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KME66_RS06620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KME66_RS06625	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KME66_RS06635	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KME66_RS06650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KME66_RS06660	COG2205	protein histidine kinase activity
KME66_RS06670	COG1126	abc transporter atp-binding protein
KME66_RS06675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KME66_RS06680	COG0765	amino acid transport
KME66_RS06685	COG0765	amino acid transport
KME66_RS06715	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KME66_RS06750	COG1917	Cupin 2, conserved barrel domain protein
KME66_RS06750	COG2207	Transcriptional regulator
KME66_RS06755	COG1201	RNA secondary structure unwinding
KME66_RS06760	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KME66_RS06765	COG1028	Short-chain dehydrogenase reductase Sdr
KME66_RS06775	COG0783	Belongs to the Dps family
KME66_RS06780	COG1396	sequence-specific DNA binding
KME66_RS06785	COG1058	Belongs to the CinA family
KME66_RS06785	COG1546	Belongs to the CinA family
KME66_RS06795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KME66_RS06805	COG1674	ftsk spoiiie
KME66_RS06815	COG2205	protein histidine kinase activity
KME66_RS06815	COG3850	Histidine kinase
KME66_RS06815	COG3437	response regulator, receiver
KME66_RS06815	COG4999	Histidine kinase
KME66_RS06845	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KME66_RS06850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KME66_RS06855	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
KME66_RS06875	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KME66_RS06880	COG0612	Peptidase, M16
KME66_RS06885	COG1185	polyribonucleotide nucleotidyltransferase activity
KME66_RS06890	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KME66_RS06900	COG1674	ftsk spoiiie
KME66_RS06915	COG1404	Belongs to the peptidase S8 family
KME66_RS06930	COG1404	Belongs to the peptidase S8 family
KME66_RS06935	COG3266	domain, Protein
KME66_RS06955	COG0455	bacterial-type flagellum organization
KME66_RS06960	COG0747	negative chemotaxis
KME66_RS06965	COG0601	transmembrane transport
KME66_RS06970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KME66_RS07000	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KME66_RS07005	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KME66_RS07030	COG0779	Required for maturation of 30S ribosomal subunits
KME66_RS07050	COG0442	prolyl-tRNA aminoacylation
KME66_RS07065	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KME66_RS07070	COG0750	zinc metalloprotease
KME66_RS07075	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KME66_RS07100	COG1012	belongs to the aldehyde dehydrogenase family
KME66_RS07105	COG2508	Transcriptional regulator
KME66_RS07135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KME66_RS07140	COG1177	transmembrane transport
KME66_RS07145	COG1176	ABC-type spermidine putrescine transport system, permease component I
KME66_RS07150	COG3842	ATPase activity
KME66_RS07155	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KME66_RS07175	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KME66_RS07195	COG1012	belongs to the aldehyde dehydrogenase family
KME66_RS07205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KME66_RS07210	COG4181	ATPase activity
KME66_RS07235	COG2197	response regulator
KME66_RS07240	COG3842	ATPase activity
KME66_RS07245	COG4208	sulfate ABC transporter
KME66_RS07255	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KME66_RS07260	COG2226	methyltransferase
KME66_RS07270	COG1051	belongs to the nudix hydrolase family
KME66_RS07350	COG0575	Belongs to the CDS family
KME66_RS07355	COG0233	cytoplasmic translational termination
KME66_RS07360	COG0528	UMP kinase activity
KME66_RS07365	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KME66_RS07370	COG0052	Belongs to the universal ribosomal protein uS2 family
KME66_RS07385	COG1191	sigma factor activity
KME66_RS07400	COG0792	nuclease activity
KME66_RS07420	COG0681	Belongs to the peptidase S26 family
KME66_RS07425	COG0681	Belongs to the peptidase S26 family
KME66_RS07430	COG0681	Belongs to the peptidase S26 family
KME66_RS07435	COG0335	large ribosomal subunit rRNA binding
KME66_RS07440	COG0336	Belongs to the RNA methyltransferase TrmD family
KME66_RS07445	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KME66_RS07450	COG1837	Belongs to the UPF0109 family
KME66_RS07455	COG0228	four-way junction DNA binding
KME66_RS07475	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
KME66_RS07510	COG0477	Major facilitator Superfamily
KME66_RS07525	COG1254	Belongs to the acylphosphatase family
KME66_RS07530	COG2340	Cysteine-rich secretory protein family
KME66_RS07535	COG1733	regulation of RNA biosynthetic process
KME66_RS07540	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KME66_RS07545	COG0571	ribonuclease III activity
KME66_RS07550	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KME66_RS07565	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KME66_RS07570	COG0742	ribosomal rna small subunit methyltransferase
KME66_RS07575	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KME66_RS07580	COG1461	Dihydroxyacetone kinase
KME66_RS07585	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KME66_RS07590	COG0351	phosphomethylpyrimidine kinase
KME66_RS07610	COG1181	Belongs to the D-alanine--D-alanine ligase family
KME66_RS07615	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KME66_RS07625	COG1920	GTP binding
KME66_RS07635	COG0776	regulation of translation
KME66_RS07645	COG0066	3-isopropylmalate dehydratase activity
KME66_RS07650	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KME66_RS07655	COG1414	Transcriptional regulator
KME66_RS07690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KME66_RS07695	COG0179	Fumarylacetoacetate (FAA) hydrolase
KME66_RS07710	COG2018	Roadblock/LC7 domain
KME66_RS07730	COG2018	Roadblock/LC7 domain
KME66_RS07750	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KME66_RS07755	COG1470	cell adhesion involved in biofilm formation
KME66_RS07755	COG0366	Alpha amylase catalytic
KME66_RS07775	COG4607	ABC-type enterochelin transport system periplasmic component
KME66_RS07780	COG1120	ATPase activity
KME66_RS07785	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KME66_RS07790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KME66_RS07840	COG0492	ferredoxin-NADP+ reductase activity
KME66_RS07855	COG3708	Transcriptional regulator
KME66_RS07855	COG2207	Transcriptional regulator
KME66_RS07870	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KME66_RS07885	COG1472	Belongs to the glycosyl hydrolase 3 family
KME66_RS07895	COG0444	Belongs to the ABC transporter superfamily
KME66_RS07900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KME66_RS07905	COG0601	transmembrane transport
KME66_RS07925	COG1609	Transcriptional regulator
KME66_RS07930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KME66_RS07940	COG2957	Belongs to the agmatine deiminase family
KME66_RS07945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KME66_RS07950	COG0473	3-isopropylmalate dehydrogenase activity
KME66_RS07965	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
KME66_RS07965	COG0778	Nitroreductase
KME66_RS07970	COG1012	belongs to the aldehyde dehydrogenase family
KME66_RS07975	COG0506	proline dehydrogenase activity
KME66_RS08000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KME66_RS08005	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KME66_RS08010	COG0440	acetolactate synthase activity
KME66_RS08020	COG3300	MHYT domain
KME66_RS08020	COG5001	Diguanylate cyclase
KME66_RS08030	COG0667	Aldo Keto reductase
KME66_RS08035	COG2133	pyrroloquinoline quinone binding
KME66_RS08045	COG2197	response regulator
KME66_RS08060	COG2409	Drug exporters of the RND superfamily
KME66_RS08070	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KME66_RS08075	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KME66_RS08085	COG0154	amidase activity
KME66_RS08090	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KME66_RS08100	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KME66_RS08110	COG4221	oxidoreductase activity
KME66_RS08130	COG0482	sulfurtransferase activity
KME66_RS08165	COG2860	membrane
KME66_RS08170	COG4608	Belongs to the ABC transporter superfamily
KME66_RS08180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KME66_RS08185	COG0601	transmembrane transport
KME66_RS08190	COG0747	negative chemotaxis
KME66_RS08210	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KME66_RS08215	COG0509	glycine decarboxylation via glycine cleavage system
KME66_RS08220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KME66_RS08225	COG1760	l-serine dehydratase
KME66_RS08275	COG2235	arginine
KME66_RS08280	COG0464	growth
KME66_RS08420	COG1132	(ABC) transporter
KME66_RS08425	COG1132	(ABC) transporter
KME66_RS08455	COG0058	SHG alpha-glucan phosphorylase activity
KME66_RS08460	COG0366	Alpha amylase catalytic
KME66_RS08465	COG0366	Alpha amylase catalytic
KME66_RS08470	COG3281	Trehalose synthase
KME66_RS08475	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KME66_RS08480	COG1301	dicarboxylic acid transport
KME66_RS08485	COG3290	protein histidine kinase activity
KME66_RS08490	COG4565	transcriptional regulatory protein
KME66_RS08500	COG0205	6-phosphofructokinase activity
KME66_RS08505	COG0280	phosphate acetyltransferase
KME66_RS08505	COG0857	belongs to the CobB CobQ family
KME66_RS08510	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KME66_RS08545	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KME66_RS08550	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KME66_RS08550	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KME66_RS08620	COG5000	phosphorelay sensor kinase activity
KME66_RS08620	COG5002	protein histidine kinase activity
KME66_RS08625	COG0745	RESPONSE REGULATOR receiver
KME66_RS08640	COG0183	Belongs to the thiolase family
KME66_RS08695	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
KME66_RS08710	COG1250	3-hydroxyacyl-CoA dehydrogenase
KME66_RS08740	COG4585	Histidine kinase
KME66_RS08745	COG2197	response regulator
KME66_RS08760	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KME66_RS08765	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KME66_RS08770	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KME66_RS08775	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KME66_RS08780	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KME66_RS08785	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KME66_RS08790	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KME66_RS08810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KME66_RS08815	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KME66_RS08820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KME66_RS08830	COG2890	protein-(glutamine-N5) methyltransferase activity
KME66_RS08835	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KME66_RS08840	COG0254	rRNA binding
KME66_RS08845	COG1316	TRANSCRIPTIONal
KME66_RS08860	COG0083	homoserine kinase activity
KME66_RS08865	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KME66_RS08870	COG0460	homoserine dehydrogenase
KME66_RS08875	COG0019	diaminopimelate decarboxylase activity
KME66_RS08880	COG0018	arginyl-trna synthetase
KME66_RS08885	COG0745	RESPONSE REGULATOR receiver
KME66_RS08910	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KME66_RS08915	COG2815	serine threonine protein kinase
KME66_RS08915	COG0515	serine threonine protein kinase
KME66_RS08920	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
KME66_RS08925	COG1793	dna ligase
KME66_RS08925	COG3285	dna ligase
KME66_RS08945	COG2205	protein histidine kinase activity
KME66_RS08960	COG0768	penicillin binding
KME66_RS09025	COG5002	protein histidine kinase activity
KME66_RS09040	COG0726	polysaccharide deacetylase
KME66_RS09045	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KME66_RS09050	COG1595	DNA-templated transcription, initiation
KME66_RS09085	COG0745	RESPONSE REGULATOR receiver
KME66_RS09090	COG2205	protein histidine kinase activity
KME66_RS09125	COG1874	Beta-galactosidase
KME66_RS09130	COG0604	alcohol dehydrogenase
KME66_RS09135	COG0281	malic enzyme
KME66_RS09140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KME66_RS09145	COG0765	amino acid transport
KME66_RS09150	COG1126	abc transporter atp-binding protein
KME66_RS09155	COG4106	trans-aconitate 2-methyltransferase activity
KME66_RS09200	COG4585	Histidine kinase
KME66_RS09205	COG2197	response regulator
KME66_RS09265	COG0142	geranyltranstransferase activity
KME66_RS09270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KME66_RS09275	COG1959	2 iron, 2 sulfur cluster binding
KME66_RS09285	COG2515	1-aminocyclopropane-1-carboxylate deaminase
KME66_RS09300	COG2172	sigma factor antagonist activity
KME66_RS09315	COG1597	lipid kinase activity
KME66_RS09330	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KME66_RS09335	COG0363	glucosamine-6-phosphate deaminase activity
KME66_RS09340	COG1472	Belongs to the glycosyl hydrolase 3 family
KME66_RS09345	COG0395	ABC-type sugar transport system, permease component
KME66_RS09350	COG1175	transmembrane transport
KME66_RS09355	COG2182	Extracellular solute-binding protein
KME66_RS09360	COG2188	Transcriptional regulator
KME66_RS09365	COG0667	Aldo Keto reductase
KME66_RS09385	COG1215	transferase activity, transferring glycosyl groups
KME66_RS09395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KME66_RS09400	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KME66_RS09410	COG1216	Glycosyl transferase, family 2
KME66_RS09410	COG1442	glycosyl transferase family 8
KME66_RS09425	COG1966	Carbon starvation protein
KME66_RS09470	COG0242	peptide deformylase activity
KME66_RS09490	COG5662	AntiSigma factor
KME66_RS09495	COG1595	DNA-templated transcription, initiation
KME66_RS09505	COG2135	peptidase activity
KME66_RS09515	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KME66_RS09520	COG1162	GTPase activity
KME66_RS09525	COG2076	Multidrug Resistance protein
KME66_RS09535	COG0483	inositol monophosphate 1-phosphatase activity
KME66_RS09545	COG0753	catalase activity
KME66_RS09570	COG1615	UPF0182 protein
KME66_RS09580	COG3480	Lon protease (S16) C-terminal proteolytic domain
KME66_RS09630	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KME66_RS09675	COG0210	DNA helicase
KME66_RS09770	COG1432	Conserved Protein
KME66_RS09780	COG2095	MarC family integral membrane protein
KME66_RS09795	COG2814	Major facilitator Superfamily
KME66_RS09805	COG0598	Magnesium transport protein CorA
KME66_RS09840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KME66_RS09855	COG1595	DNA-templated transcription, initiation
KME66_RS09870	COG1024	Enoyl-CoA hydratase
KME66_RS09875	COG0519	Catalyzes the synthesis of GMP from XMP
KME66_RS09885	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KME66_RS09890	COG1611	Belongs to the LOG family
KME66_RS09895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KME66_RS09925	COG2912	Transglutaminase-like superfamily
KME66_RS09930	COG2197	response regulator
KME66_RS09935	COG1132	(ABC) transporter
KME66_RS09940	COG1132	(ABC) transporter
KME66_RS09950	COG0515	serine threonine protein kinase
KME66_RS09970	COG0110	maltose O-acetyltransferase activity
KME66_RS09980	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KME66_RS09995	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KME66_RS10010	COG4608	Belongs to the ABC transporter superfamily
KME66_RS10015	COG0444	Belongs to the ABC transporter superfamily
KME66_RS10020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KME66_RS10025	COG0601	transmembrane transport
KME66_RS10035	COG4608	Belongs to the ABC transporter superfamily
KME66_RS10040	COG0444	Belongs to the ABC transporter superfamily
KME66_RS10045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KME66_RS10050	COG0601	transmembrane transport
KME66_RS10060	COG1217	gtp-binding protein TYPA
KME66_RS10070	COG1609	Transcriptional regulator
KME66_RS10085	COG1175	transmembrane transport
KME66_RS10090	COG0395	ABC-type sugar transport system, permease component
KME66_RS10165	COG1028	Short-chain dehydrogenase reductase Sdr
KME66_RS10170	COG1012	belongs to the aldehyde dehydrogenase family
KME66_RS10190	COG0463	Glycosyl transferase, family 2
KME66_RS10200	COG1842	Phage shock protein A
KME66_RS10290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KME66_RS10305	COG1917	Cupin 2, conserved barrel domain protein
KME66_RS10305	COG2169	Transcriptional regulator
KME66_RS10320	COG1131	(ABC) transporter
KME66_RS10325	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KME66_RS10345	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KME66_RS10380	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KME66_RS10425	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KME66_RS10435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KME66_RS10440	COG1028	Short-chain dehydrogenase reductase Sdr
KME66_RS10455	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KME66_RS10510	COG0154	amidase activity
KME66_RS10535	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KME66_RS10555	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KME66_RS10570	COG1132	(ABC) transporter
KME66_RS10575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KME66_RS10595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KME66_RS10600	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
KME66_RS10620	COG0529	Catalyzes the synthesis of activated sulfate
KME66_RS10630	COG2197	response regulator
KME66_RS10635	COG4585	Histidine kinase
KME66_RS10660	COG0736	holo-[acyl-carrier-protein] synthase activity
KME66_RS10680	COG0012	GTP binding
KME66_RS10695	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KME66_RS10705	COG1570	exodeoxyribonuclease VII activity
KME66_RS10710	COG1722	exodeoxyribonuclease VII activity
KME66_RS10715	COG0778	Nitroreductase
KME66_RS10740	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
KME66_RS10740	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
KME66_RS10755	COG0604	alcohol dehydrogenase
KME66_RS10755	COG3321	synthase
KME66_RS10765	COG1362	aminopeptidase activity
KME66_RS10780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KME66_RS10785	COG2755	lipolytic protein G-D-S-L family
KME66_RS10790	COG0114	fumarate hydratase activity
KME66_RS10805	COG4499	WXG100 protein secretion system (Wss), protein YukC
KME66_RS10805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KME66_RS10825	COG1136	(ABC) transporter
KME66_RS10840	COG0450	alkyl hydroperoxide reductase
KME66_RS10845	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KME66_RS10860	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KME66_RS10865	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KME66_RS10870	COG0667	Aldo Keto reductase
KME66_RS10880	COG2226	methyltransferase
KME66_RS10925	COG2885	chlorophyll binding
KME66_RS10945	COG2197	response regulator
KME66_RS10950	COG3920	Histidine kinase
KME66_RS10980	COG2894	cell division
KME66_RS11010	COG2610	gluconate transmembrane transporter activity
KME66_RS11015	COG0251	oxidation-reduction process
KME66_RS11020	COG1414	Transcriptional regulator
KME66_RS11035	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
KME66_RS11065	COG0436	Aminotransferase
KME66_RS11075	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
KME66_RS11085	COG1331	Highly conserved protein containing a thioredoxin domain
KME66_RS11100	COG1309	transcriptional regulator
KME66_RS11125	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KME66_RS11135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KME66_RS11150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KME66_RS11160	COG1366	Belongs to the anti-sigma-factor antagonist family
KME66_RS11165	COG1366	Belongs to the anti-sigma-factor antagonist family
KME66_RS11170	COG2172	sigma factor antagonist activity
KME66_RS11180	COG3850	Histidine kinase
KME66_RS11180	COG3437	response regulator, receiver
KME66_RS11180	COG4999	Histidine kinase
KME66_RS11180	COG2205	protein histidine kinase activity
KME66_RS11185	COG0745	RESPONSE REGULATOR receiver
KME66_RS11190	COG1595	DNA-templated transcription, initiation
KME66_RS11220	COG0583	DNA-binding transcription factor activity
KME66_RS11225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KME66_RS11255	COG1396	sequence-specific DNA binding
KME66_RS11260	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KME66_RS11275	COG1376	ErfK ybiS ycfS ynhG family protein
KME66_RS11300	COG1024	Enoyl-CoA hydratase
KME66_RS11315	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KME66_RS11325	COG0424	maF-like protein
KME66_RS11335	COG4770	biotin carboxylase activity
KME66_RS11365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KME66_RS11380	COG1012	belongs to the aldehyde dehydrogenase family
KME66_RS11385	COG1012	belongs to the aldehyde dehydrogenase family
KME66_RS11425	COG1595	DNA-templated transcription, initiation
KME66_RS11430	COG0745	RESPONSE REGULATOR receiver
KME66_RS11435	COG2205	protein histidine kinase activity
KME66_RS11460	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KME66_RS11470	COG0583	DNA-binding transcription factor activity
KME66_RS11475	COG2814	Major facilitator Superfamily
KME66_RS11495	COG1404	Belongs to the peptidase S8 family
KME66_RS11510	COG1079	Belongs to the binding-protein-dependent transport system permease family
KME66_RS11515	COG4603	Belongs to the binding-protein-dependent transport system permease family
KME66_RS11520	COG3845	ABC transporter
KME66_RS11525	COG1744	ABC transporter substrate-binding protein PnrA-like
KME66_RS11530	COG1473	amidohydrolase
KME66_RS11530	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
KME66_RS11540	COG2089	acid synthase
KME66_RS11545	COG1083	cytidylyl-transferase
KME66_RS11555	COG1216	Glycosyl transferase, family 2
KME66_RS11585	COG1216	Glycosyl transferase, family 2
KME66_RS11605	COG1595	DNA-templated transcription, initiation
KME66_RS11610	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KME66_RS11615	COG0733	neurotransmitter:sodium symporter activity
KME66_RS11630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KME66_RS11635	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
KME66_RS11640	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
KME66_RS11645	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KME66_RS11680	COG2009	succinate dehydrogenase
KME66_RS11695	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KME66_RS11720	COG1408	metallophosphoesterase
KME66_RS11725	COG1686	Belongs to the peptidase S11 family
KME66_RS11730	COG1295	ribonuclease BN
KME66_RS11750	COG0180	Tryptophanyl-tRNA synthetase
KME66_RS11755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KME66_RS11760	COG0754	glutathionylspermidine amidase activity
KME66_RS11770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KME66_RS11775	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KME66_RS11795	COG0039	L-malate dehydrogenase activity
KME66_RS11810	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KME66_RS11825	COG0138	bifunctional purine biosynthesis protein purh
KME66_RS11855	COG0045	succinate-CoA ligase (ADP-forming) activity
KME66_RS11870	COG3552	Protein containing von Willebrand factor type A (VWA) domain
KME66_RS11880	COG0714	Associated with various cellular activities
KME66_RS11910	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KME66_RS11920	COG0739	heme binding
KME66_RS11945	COG2197	response regulator
KME66_RS11985	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KME66_RS11995	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KME66_RS11995	COG0519	Catalyzes the synthesis of GMP from XMP
KME66_RS12015	COG1012	belongs to the aldehyde dehydrogenase family
KME66_RS12050	COG0516	GMP reductase activity
KME66_RS12060	COG1595	DNA-templated transcription, initiation
KME66_RS12075	COG0583	DNA-binding transcription factor activity
KME66_RS12085	COG0300	oxidoreductase activity
KME66_RS12095	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KME66_RS12100	COG0726	polysaccharide deacetylase
KME66_RS12125	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KME66_RS12150	COG0802	atpase or kinase
KME66_RS12160	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KME66_RS12165	COG3189	MarR family transcriptional regulator
KME66_RS12175	COG0736	holo-[acyl-carrier-protein] synthase activity
KME66_RS12180	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KME66_RS12220	COG4941	Belongs to the sigma-70 factor family
KME66_RS12225	COG3795	YCII-related domain
KME66_RS12230	COG0596	Alpha beta hydrolase
KME66_RS12260	COG0569	domain protein
KME66_RS12265	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KME66_RS12275	COG1072	(Pantothenic acid kinase))
KME66_RS12290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KME66_RS12295	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KME66_RS12300	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KME66_RS12305	COG0488	(ABC) transporter
KME66_RS12315	COG0101	tRNA pseudouridine synthase activity
KME66_RS12320	COG0203	ribosomal protein L17
KME66_RS12325	COG0202	RNA polymerase activity
KME66_RS12330	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KME66_RS12335	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KME66_RS12340	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KME66_RS12345	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KME66_RS12355	COG0563	adenylate kinase activity
KME66_RS12365	COG0200	Binds to the 23S rRNA
KME66_RS12370	COG1841	ribosomal large subunit assembly
KME66_RS12375	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KME66_RS12380	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KME66_RS12385	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KME66_RS12390	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KME66_RS12395	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KME66_RS12400	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KME66_RS12405	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KME66_RS12410	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KME66_RS12415	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KME66_RS12420	COG0255	Belongs to the universal ribosomal protein uL29 family
KME66_RS12425	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KME66_RS12430	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KME66_RS12435	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KME66_RS12440	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KME66_RS12445	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KME66_RS12450	COG0089	rRNA binding
KME66_RS12455	COG0088	Forms part of the polypeptide exit tunnel
KME66_RS12460	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KME66_RS12465	COG0051	transcription antitermination factor activity, RNA binding
KME66_RS12480	COG2197	response regulator
KME66_RS12500	COG4585	Histidine kinase
KME66_RS12505	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KME66_RS12510	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KME66_RS12515	COG0049	tRNA binding
KME66_RS12520	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KME66_RS12530	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KME66_RS12535	COG0085	RNA polymerase activity
KME66_RS12540	COG0222	ribosome binding
KME66_RS12545	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KME66_RS12555	COG0081	regulation of translation
KME66_RS12560	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KME66_RS12580	COG0436	Aminotransferase
KME66_RS12585	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KME66_RS12590	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KME66_RS12600	COG2030	dehydratase
KME66_RS12605	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KME66_RS12625	COG0702	epimerase
KME66_RS12635	COG1666	GTP binding
KME66_RS12640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KME66_RS12655	COG3304	Inner membrane component domain
KME66_RS12660	COG0501	Belongs to the peptidase M48B family
KME66_RS12665	COG1970	mechanosensitive ion channel activity
KME66_RS12670	COG1007	ATP synthesis coupled electron transport
KME66_RS12680	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KME66_RS12685	COG0713	ATP synthesis coupled electron transport
KME66_RS12690	COG0839	Belongs to the complex I subunit 6 family
KME66_RS12695	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KME66_RS12700	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KME66_RS12710	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KME66_RS12715	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KME66_RS12735	COG0674	pyruvate-flavodoxin oxidoreductase activity
KME66_RS12735	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KME66_RS12740	COG1013	pyruvate-flavodoxin oxidoreductase activity
KME66_RS12745	COG1733	regulation of RNA biosynthetic process
KME66_RS12750	COG0702	epimerase
KME66_RS12785	COG0702	epimerase
KME66_RS12790	COG1733	regulation of RNA biosynthetic process
KME66_RS12815	COG0561	phosphatase activity
KME66_RS12845	COG1131	(ABC) transporter
KME66_RS12855	COG0142	geranyltranstransferase activity
KME66_RS12870	COG0179	Fumarylacetoacetate (FAA) hydrolase
KME66_RS12890	COG1007	ATP synthesis coupled electron transport
KME66_RS12900	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KME66_RS12905	COG0713	ATP synthesis coupled electron transport
KME66_RS12910	COG0839	Belongs to the complex I subunit 6 family
KME66_RS12915	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KME66_RS12920	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KME66_RS12925	COG1034	ATP synthesis coupled electron transport
KME66_RS12930	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KME66_RS12940	COG0649	NAD binding
KME66_RS12945	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KME66_RS12950	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KME66_RS13000	COG2226	methyltransferase
KME66_RS13015	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
KME66_RS13025	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
KME66_RS13030	COG1278	Cold shock
KME66_RS13100	COG1309	transcriptional regulator
KME66_RS13110	COG1960	acyl-CoA dehydrogenase activity
KME66_RS13120	COG0259	pyridoxamine-phosphate oxidase activity
KME66_RS13125	COG0501	Belongs to the peptidase M48B family
KME66_RS13155	COG2072	flavoprotein involved in K transport
KME66_RS13175	COG0577	efflux transmembrane transporter activity
KME66_RS13175	COG1136	(ABC) transporter
KME66_RS13180	COG0577	efflux transmembrane transporter activity
KME66_RS13180	COG1136	(ABC) transporter
KME66_RS13190	COG0745	RESPONSE REGULATOR receiver
KME66_RS13195	COG2205	protein histidine kinase activity
KME66_RS13215	COG1024	Enoyl-CoA hydratase
KME66_RS13220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KME66_RS13225	COG3629	intracellular signal transduction
KME66_RS13225	COG3903	Transcriptional regulator
KME66_RS13245	COG2814	Major facilitator Superfamily
KME66_RS13275	COG1960	acyl-CoA dehydrogenase activity
KME66_RS13280	COG1028	Short-chain dehydrogenase reductase Sdr
KME66_RS13295	COG1960	acyl-CoA dehydrogenase activity
KME66_RS13300	COG1960	acyl-CoA dehydrogenase activity
KME66_RS13310	COG0318	PFAM AMP-dependent synthetase and ligase
KME66_RS13320	COG1366	Belongs to the anti-sigma-factor antagonist family
KME66_RS13395	COG1131	(ABC) transporter
KME66_RS13405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KME66_RS13415	COG4821	SIS domain
KME66_RS13430	COG0259	pyridoxamine-phosphate oxidase activity
KME66_RS13455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KME66_RS13495	COG1024	Enoyl-CoA hydratase
KME66_RS13500	COG0318	PFAM AMP-dependent synthetase and ligase
KME66_RS13515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KME66_RS13530	COG1051	belongs to the nudix hydrolase family
KME66_RS13540	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
KME66_RS13550	COG0583	DNA-binding transcription factor activity
KME66_RS13555	COG0277	FAD linked oxidase domain protein
KME66_RS13555	COG0247	lactate metabolic process
KME66_RS13560	COG2205	protein histidine kinase activity
KME66_RS13590	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KME66_RS13665	COG0697	spore germination
KME66_RS13675	COG1309	transcriptional regulator
KME66_RS13785	COG0583	DNA-binding transcription factor activity
KME66_RS13790	COG1028	Short-chain dehydrogenase reductase Sdr
KME66_RS13795	COG1028	Short-chain dehydrogenase reductase Sdr
KME66_RS13800	COG0515	serine threonine protein kinase
KME66_RS13810	COG2267	carboxylic ester hydrolase activity
KME66_RS13825	COG0667	Aldo Keto reductase
KME66_RS13850	COG2252	PERMEase
KME66_RS13860	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KME66_RS13880	COG2814	Major facilitator Superfamily
KME66_RS13890	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KME66_RS13895	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
KME66_RS13915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KME66_RS13920	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KME66_RS13925	COG1120	ATPase activity
KME66_RS13930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KME66_RS13975	COG1061	Type III restriction enzyme res subunit
KME66_RS13985	COG3973	AAA domain
KME66_RS14000	COG1984	allophanate hydrolase subunit 2
KME66_RS14010	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
KME66_RS14045	COG1737	Transcriptional regulator
KME66_RS14050	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KME66_RS14055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KME66_RS14055	COG1263	PTS System
KME66_RS14070	COG0784	Response regulator, receiver
KME66_RS14075	COG4251	negative regulation of phosphorylation
KME66_RS14100	COG1175	transmembrane transport
KME66_RS14105	COG0395	ABC-type sugar transport system, permease component
KME66_RS14120	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KME66_RS14165	COG1595	DNA-templated transcription, initiation
KME66_RS14175	COG1132	(ABC) transporter
KME66_RS14220	COG0463	Glycosyl transferase, family 2
KME66_RS14225	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
KME66_RS14235	COG0577	efflux transmembrane transporter activity
KME66_RS14240	COG0577	efflux transmembrane transporter activity
KME66_RS14240	COG1136	(ABC) transporter
KME66_RS14250	COG2197	response regulator
KME66_RS14255	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
KME66_RS14295	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KME66_RS14300	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KME66_RS14305	COG1754	DNA topoisomerase type I activity
KME66_RS14305	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KME66_RS14315	COG2890	protein-(glutamine-N5) methyltransferase activity
KME66_RS14325	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
KME66_RS14330	COG2172	sigma factor antagonist activity
KME66_RS14335	COG1366	Belongs to the anti-sigma-factor antagonist family
KME66_RS14340	COG1111	helicase
KME66_RS14340	COG1205	dead DEAH box helicase
KME66_RS14400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KME66_RS14435	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KME66_RS14440	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KME66_RS14770	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
KME66_RS14785	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KME66_RS14795	COG2267	carboxylic ester hydrolase activity
KME66_RS14820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KME66_RS14830	COG0251	oxidation-reduction process
KME66_RS14845	COG0003	Pfam Anion-transporting ATPase
KME66_RS14855	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KME66_RS14860	COG1610	YqeY-like protein
KME66_RS14865	COG1408	metallophosphoesterase
KME66_RS14965	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KME66_RS14980	COG0475	glutathione-regulated potassium exporter activity
KME66_RS14995	COG0583	DNA-binding transcription factor activity
KME66_RS15015	COG1846	Transcriptional regulator
KME66_RS15040	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KME66_RS15050	COG2226	methyltransferase
KME66_RS15055	COG0640	Transcriptional regulator
KME66_RS15060	COG0798	PFAM Bile acid sodium symporter
KME66_RS15065	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KME66_RS15080	COG2755	lipolytic protein G-D-S-L family
KME66_RS15090	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KME66_RS15110	COG1595	DNA-templated transcription, initiation
KME66_RS15140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KME66_RS15145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KME66_RS15165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KME66_RS15170	COG0693	protein deglycase activity
KME66_RS15180	COG0515	serine threonine protein kinase
KME66_RS15180	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KME66_RS15185	COG3226	Transcriptional regulator
KME66_RS15265	COG0592	DNA-directed DNA polymerase activity
KME66_RS15270	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KME66_RS15275	COG0667	Aldo Keto reductase
KME66_RS15300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KME66_RS15310	COG0662	Cupin 2, conserved barrel domain protein
KME66_RS15315	COG1960	acyl-CoA dehydrogenase activity
KME66_RS15365	COG2076	Multidrug Resistance protein
KME66_RS15370	COG0590	tRNA wobble adenosine to inosine editing
KME66_RS15380	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KME66_RS15385	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KME66_RS15410	COG2197	response regulator
KME66_RS15415	COG4585	Histidine kinase
KME66_RS15425	COG3844	kynureninase activity
KME66_RS15440	COG0477	Major facilitator Superfamily
KME66_RS15445	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KME66_RS15450	COG0191	fructose-bisphosphate aldolase activity
KME66_RS15455	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KME66_RS15470	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KME66_RS15505	COG0542	response to heat
KME66_RS15540	COG0789	Transcriptional regulator
KME66_RS15545	COG0484	heat shock protein binding
KME66_RS15550	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KME66_RS15555	COG0443	Heat shock 70 kDa protein
KME66_RS15560	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KME66_RS15565	COG0247	lactate metabolic process
KME66_RS15565	COG2181	nitrate reductase activity
KME66_RS15585	COG0717	Belongs to the dCTP deaminase family
KME66_RS15615	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KME66_RS15710	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KME66_RS15725	COG1073	alpha beta
KME66_RS15730	COG1073	alpha beta
KME66_RS15755	COG0277	FAD linked oxidase domain protein
KME66_RS15775	COG2897	thiosulfate sulfurtransferase activity
KME66_RS15840	COG1609	Transcriptional regulator
KME66_RS15865	COG2124	cytochrome p450
KME66_RS15870	COG1024	Enoyl-CoA hydratase
KME66_RS15885	COG3585	molybdate ion transport
KME66_RS15910	COG0531	amino acid
KME66_RS15920	COG0475	glutathione-regulated potassium exporter activity
KME66_RS15925	COG2409	Drug exporters of the RND superfamily
KME66_RS15930	COG3594	Acyltransferase
KME66_RS15935	COG0513	Belongs to the DEAD box helicase family
KME66_RS15940	COG1278	Cold shock
KME66_RS16000	COG2268	Band 7 protein
KME66_RS16025	COG4941	Belongs to the sigma-70 factor family
KME66_RS16050	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KME66_RS16105	COG1191	sigma factor activity
KME66_RS16110	COG1191	sigma factor activity
KME66_RS16125	COG1846	Transcriptional regulator
KME66_RS16135	COG2353	YceI-like domain
KME66_RS16140	COG3467	pyridoxamine 5'-phosphate
KME66_RS16155	COG0477	Major facilitator Superfamily
KME66_RS16170	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KME66_RS16180	COG2205	protein histidine kinase activity
KME66_RS16185	COG0745	RESPONSE REGULATOR receiver
KME66_RS16210	COG1595	DNA-templated transcription, initiation
KME66_RS16215	COG1252	NADH dehydrogenase
KME66_RS16255	COG0318	PFAM AMP-dependent synthetase and ligase
KME66_RS16260	COG1595	DNA-templated transcription, initiation
KME66_RS16290	COG1960	acyl-CoA dehydrogenase activity
KME66_RS16445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KME66_RS16460	COG0653	protein targeting
KME66_RS16475	COG0006	proline dipeptidase activity
KME66_RS16495	COG1999	signal sequence binding
KME66_RS16505	COG2372	response to copper ion
KME66_RS16510	COG2837	iron assimilation
KME66_RS16515	COG0077	Prephenate dehydratase
KME66_RS16520	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KME66_RS16525	COG0561	phosphatase activity
KME66_RS16550	COG1131	(ABC) transporter
KME66_RS16565	COG0789	Transcriptional regulator
KME66_RS16570	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
KME66_RS16585	COG0561	phosphatase activity
KME66_RS16595	COG4988	ABC transporter
KME66_RS16600	COG1294	oxidase, subunit
KME66_RS16605	COG1271	oxidase subunit
KME66_RS16610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KME66_RS16615	COG1609	Transcriptional regulator
KME66_RS16630	COG3152	Membrane
KME66_RS16635	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KME66_RS16660	COG0662	Cupin 2, conserved barrel domain protein
KME66_RS16665	COG1950	PFAM Membrane protein of
KME66_RS16670	COG0626	cystathionine gamma-synthase activity
KME66_RS16685	COG2814	Major facilitator Superfamily
KME66_RS16710	COG0305	Participates in initiation and elongation during chromosome replication
KME66_RS16720	COG0359	binds to the 23S rRNA
KME66_RS16725	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KME66_RS16730	COG0629	single-stranded DNA binding
KME66_RS16735	COG0360	Binds together with S18 to 16S ribosomal RNA
KME66_RS16760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KME66_RS16780	COG0617	tRNA 3'-terminal CCA addition
KME66_RS16795	COG2815	serine threonine protein kinase
KME66_RS16795	COG0515	serine threonine protein kinase
KME66_RS16800	COG1595	DNA-templated transcription, initiation
KME66_RS16810	COG0492	ferredoxin-NADP+ reductase activity
KME66_RS16815	COG3118	belongs to the thioredoxin family
KME66_RS16830	COG1192	Involved in chromosome partitioning
KME66_RS16835	COG0357	Ribosomal RNA small subunit methyltransferase G
KME66_RS16845	COG0706	membrane insertase activity
KME66_RS16850	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KME66_RS16855	COG0594	ribonuclease P activity
KME66_RS16860	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KME66_RS16870	COG0592	DNA-directed DNA polymerase activity
KME66_RS16875	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KME66_RS16880	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KME66_RS16885	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
KME66_RS16895	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KME66_RS16930	COG0515	serine threonine protein kinase
KME66_RS16960	COG0705	Rhomboid family
KME66_RS16975	COG3764	Sortase (surface protein transpeptidase)
KME66_RS16990	COG3764	Sortase (surface protein transpeptidase)
KME66_RS16995	COG3764	Sortase (surface protein transpeptidase)
KME66_RS17000	COG0515	serine threonine protein kinase
KME66_RS17005	COG0768	penicillin binding
KME66_RS17020	COG1716	ATPase activity
KME66_RS17025	COG1716	ATPase activity
KME66_RS17070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KME66_RS17075	COG2151	metal-sulfur cluster biosynthetic enzyme
KME66_RS17080	COG3396	Phenylacetate-CoA oxygenase
KME66_RS17085	COG3460	Phenylacetate-CoA oxygenase
KME66_RS17090	COG3396	Phenylacetate-CoA oxygenase
KME66_RS17115	COG1309	transcriptional regulator
KME66_RS17120	COG1522	sequence-specific DNA binding
KME66_RS17170	COG1136	(ABC) transporter
KME66_RS17170	COG4591	ABC-type transport system involved in lipoprotein release permease component
KME66_RS17185	COG0515	serine threonine protein kinase
KME66_RS17190	COG0515	serine threonine protein kinase
KME66_RS17215	COG0022	dehydrogenase e1 component
KME66_RS17220	COG0508	dehydrogenase complex catalyzes the overall conversion of
KME66_RS17230	COG1802	Transcriptional regulator
KME66_RS17235	COG2271	Major facilitator Superfamily
KME66_RS17270	COG1362	aminopeptidase activity
KME66_RS17280	COG1960	acyl-CoA dehydrogenase activity
KME66_RS17290	COG1741	Belongs to the pirin family
KME66_RS17305	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KME66_RS17315	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KME66_RS17320	COG0745	RESPONSE REGULATOR receiver
KME66_RS17325	COG2205	protein histidine kinase activity
KME66_RS17330	COG2304	oxidoreductase activity
KME66_RS17360	COG0431	NADPH-dependent FMN reductase
KME66_RS17380	COG1672	PFAM Archaeal ATPase
KME66_RS17380	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
KME66_RS17395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KME66_RS17400	COG0180	Tryptophanyl-tRNA synthetase
KME66_RS17410	COG2255	four-way junction helicase activity
KME66_RS17430	COG0475	glutathione-regulated potassium exporter activity
KME66_RS17435	COG0490	domain, Protein
KME66_RS17455	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
KME66_RS17540	COG3629	intracellular signal transduction
KME66_RS17540	COG3903	Transcriptional regulator
KME66_RS17560	COG1045	serine acetyltransferase
KME66_RS17585	COG0367	asparagine synthase
KME66_RS17630	COG3335	DDE superfamily endonuclease
KME66_RS17675	COG1051	belongs to the nudix hydrolase family
KME66_RS17700	COG0151	Belongs to the GarS family
KME66_RS17715	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KME66_RS17725	COG2197	response regulator
KME66_RS17760	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KME66_RS17765	COG0047	phosphoribosylformylglycinamidine synthase activity
KME66_RS17770	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KME66_RS17780	COG0739	heme binding
KME66_RS17800	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KME66_RS17835	COG1643	Atp-dependent helicase
KME66_RS17845	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KME66_RS17845	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KME66_RS17850	COG4232	protein-disulfide reductase activity
KME66_RS17885	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KME66_RS17890	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KME66_RS17900	COG0513	Belongs to the DEAD box helicase family
KME66_RS17930	COG0739	heme binding
KME66_RS17930	COG0741	lytic transglycosylase activity
KME66_RS17930	COG1196	nuclear chromosome segregation
KME66_RS17945	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KME66_RS17950	COG0579	oxidoreductase
KME66_RS17975	COG1252	NADH dehydrogenase
KME66_RS17990	COG1846	Transcriptional regulator
KME66_RS18010	COG2197	response regulator
KME66_RS18015	COG4585	Histidine kinase
KME66_RS18025	COG1131	(ABC) transporter
KME66_RS18090	COG0739	heme binding
KME66_RS18090	COG0741	lytic transglycosylase activity
KME66_RS18090	COG1196	nuclear chromosome segregation
KME66_RS18095	COG0671	phosphoesterase, PA-phosphatase related
KME66_RS18115	COG1937	Protein conserved in bacteria
KME66_RS18125	COG0306	phosphate transporter
KME66_RS18145	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KME66_RS18150	COG0494	nUDIX hydrolase
KME66_RS18150	COG0406	alpha-ribazole phosphatase activity
KME66_RS18170	COG3842	ATPase activity
KME66_RS18175	COG1725	Transcriptional regulator
KME66_RS18180	COG0456	acetyltransferase
KME66_RS18185	COG0737	Belongs to the 5'-nucleotidase family
KME66_RS18230	COG3311	Transcriptional regulator
KME66_RS18235	COG1569	PIN domain
KME66_RS18250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KME66_RS18255	COG1609	Transcriptional regulator
KME66_RS18260	COG0745	RESPONSE REGULATOR receiver
KME66_RS18285	COG2897	thiosulfate sulfurtransferase activity
KME66_RS18320	COG3485	protocatechuate 3,4-dioxygenase
KME66_RS18325	COG0735	belongs to the Fur family
KME66_RS18335	COG1490	D-aminoacyl-tRNA deacylase activity
KME66_RS18350	COG4552	Acetyltransferase involved in intracellular survival and related
KME66_RS18390	COG0789	Transcriptional regulator
KME66_RS18425	COG0438	transferase activity, transferring glycosyl groups
KME66_RS18460	COG0588	phosphoglycerate mutase activity
KME66_RS18475	COG5002	protein histidine kinase activity
KME66_RS18490	COG1329	Transcriptional regulator
KME66_RS18495	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KME66_RS18500	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KME66_RS18505	COG3467	pyridoxamine 5'-phosphate
KME66_RS18510	COG0215	cysteine-tRNA ligase activity
KME66_RS18515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KME66_RS18525	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KME66_RS18535	COG3842	ATPase activity
KME66_RS18575	COG2208	phosphoserine phosphatase activity
KME66_RS18575	COG2770	Histidine kinase
KME66_RS18610	COG2814	Major facilitator Superfamily
KME66_RS18620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KME66_RS18660	COG2197	response regulator
KME66_RS18665	COG4585	Histidine kinase
KME66_RS18695	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KME66_RS18720	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KME66_RS18755	COG1595	DNA-templated transcription, initiation
KME66_RS18800	COG1012	belongs to the aldehyde dehydrogenase family
KME66_RS18820	COG0076	glutamate decarboxylase activity
KME66_RS18825	COG0655	NAD(P)H dehydrogenase (quinone) activity
KME66_RS18845	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KME66_RS18850	COG2027	D-alanyl-D-alanine carboxypeptidase
KME66_RS18860	COG0037	tRNA processing
KME66_RS18875	COG0302	gtp cyclohydrolase
KME66_RS18885	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KME66_RS18890	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KME66_RS18905	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KME66_RS18905	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KME66_RS18915	COG0517	IMP dehydrogenase activity
KME66_RS18915	COG1125	glycine betaine transport
KME66_RS18920	COG1174	glycine betaine transport
KME66_RS18925	COG1174	glycine betaine transport
KME66_RS18940	COG0649	NAD binding
KME66_RS18955	COG2197	response regulator
KME66_RS18985	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KME66_RS18990	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KME66_RS19000	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KME66_RS19020	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KME66_RS19050	COG0739	heme binding
KME66_RS19055	COG2205	protein histidine kinase activity
KME66_RS19060	COG0745	RESPONSE REGULATOR receiver
KME66_RS19070	COG1595	DNA-templated transcription, initiation
KME66_RS19075	COG1194	a g-specific adenine glycosylase
KME66_RS19085	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
KME66_RS19105	COG0248	Ppx GppA phosphatase
KME66_RS19110	COG1082	Xylose isomerase domain protein TIM barrel
KME66_RS19120	COG0129	dihydroxy-acid dehydratase activity
KME66_RS19125	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KME66_RS19125	COG0515	serine threonine protein kinase
KME66_RS19130	COG4991	sh3 domain protein
KME66_RS19140	COG0842	Transport permease protein
KME66_RS19140	COG1129	ABC transporter
KME66_RS19150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KME66_RS19170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KME66_RS19175	COG2223	nitrite transmembrane transporter activity
KME66_RS19230	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KME66_RS19235	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KME66_RS19240	COG0181	hydroxymethylbilane synthase activity
KME66_RS19245	COG1648	precorrin-2 dehydrogenase activity
KME66_RS19245	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KME66_RS19250	COG0113	porphobilinogen synthase activity
KME66_RS19265	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KME66_RS19300	COG0018	arginyl-trna synthetase
KME66_RS19305	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
KME66_RS19330	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KME66_RS19340	COG2409	Drug exporters of the RND superfamily
KME66_RS19350	COG0142	geranyltranstransferase activity
KME66_RS19355	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KME66_RS19365	COG3903	Transcriptional regulator
KME66_RS19365	COG3629	intracellular signal transduction
KME66_RS19375	COG3903	Transcriptional regulator
KME66_RS19375	COG3629	intracellular signal transduction
KME66_RS19400	COG1690	Belongs to the RtcB family
KME66_RS19410	COG2188	Transcriptional regulator
KME66_RS19420	COG1178	ABC-type Fe3 transport system permease component
KME66_RS19430	COG3842	ATPase activity
KME66_RS19465	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KME66_RS19470	COG0406	alpha-ribazole phosphatase activity
KME66_RS19485	COG0785	Cytochrome C biogenesis protein
KME66_RS19490	COG1333	cytochrome c biogenesis protein
KME66_RS19495	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KME66_RS19505	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
KME66_RS19510	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KME66_RS19520	COG0163	prenyltransferase activity
KME66_RS19535	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
KME66_RS19550	COG1301	dicarboxylic acid transport
KME66_RS19605	COG1309	transcriptional regulator
KME66_RS19615	COG1028	Short-chain dehydrogenase reductase Sdr
KME66_RS19650	COG2353	YceI-like domain
KME66_RS19695	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
KME66_RS19735	COG0768	penicillin binding
KME66_RS19780	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
KME66_RS19850	COG1686	Belongs to the peptidase S11 family
KME66_RS19880	COG1011	Hydrolase
KME66_RS19925	COG0515	serine threonine protein kinase
KME66_RS19925	COG2815	serine threonine protein kinase
KME66_RS19955	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KME66_RS19975	COG1115	amino acid carrier protein
KME66_RS19980	COG0151	Belongs to the GarS family
KME66_RS20030	COG2814	Major facilitator Superfamily
KME66_RS20055	COG0506	proline dehydrogenase activity
KME66_RS20095	COG1846	Transcriptional regulator
KME66_RS20100	COG3384	dioxygenase
KME66_RS20115	COG0477	Major facilitator Superfamily
KME66_RS20125	COG3191	aminopeptidase activity
KME66_RS20135	COG1970	mechanosensitive ion channel activity
KME66_RS20150	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KME66_RS20175	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KME66_RS20180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KME66_RS20190	COG0315	cyclic pyranopterin monophosphate synthase activity
KME66_RS20195	COG0521	Mo-molybdopterin cofactor biosynthetic process
KME66_RS20200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KME66_RS20440	COG0629	single-stranded DNA binding
KME66_RS20530	COG0708	Exodeoxyribonuclease III
KME66_RS20540	COG2072	flavoprotein involved in K transport
KME66_RS20550	COG1028	Short-chain dehydrogenase reductase Sdr
KME66_RS20565	COG4946	Tricorn protease homolog
KME66_RS20565	COG0793	Belongs to the peptidase S41A family
KME66_RS20575	COG2409	Drug exporters of the RND superfamily
KME66_RS20585	COG0310	cobalt ion transport
KME66_RS20595	COG1122	ATPase activity
KME66_RS20600	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KME66_RS20615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KME66_RS20635	COG1115	amino acid carrier protein
KME66_RS20655	COG4585	Histidine kinase
KME66_RS20660	COG2197	response regulator
KME66_RS20690	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KME66_RS20720	COG0084	hydrolase, TatD family'
KME66_RS20725	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KME66_RS20730	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KME66_RS20765	COG2197	response regulator
KME66_RS20770	COG0488	(ABC) transporter
KME66_RS20800	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KME66_RS20815	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KME66_RS20825	COG2197	response regulator
KME66_RS20830	COG1846	Transcriptional regulator
KME66_RS20835	COG4106	trans-aconitate 2-methyltransferase activity
KME66_RS20850	COG1309	transcriptional regulator
KME66_RS20860	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
KME66_RS20870	COG0193	aminoacyl-tRNA hydrolase activity
KME66_RS20875	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KME66_RS20880	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KME66_RS20885	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KME66_RS20900	COG4585	Histidine kinase
KME66_RS20930	COG0667	Aldo Keto reductase
KME66_RS20940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KME66_RS20945	COG2124	cytochrome p450
KME66_RS20995	COG0346	lactoylglutathione lyase activity
KME66_RS21005	COG0477	Major facilitator Superfamily
KME66_RS21010	COG1136	(ABC) transporter
KME66_RS21015	COG0577	efflux transmembrane transporter activity
KME66_RS21025	COG3903	Transcriptional regulator
KME66_RS21025	COG3629	intracellular signal transduction
KME66_RS21085	COG1473	amidohydrolase
KME66_RS21195	COG0148	phosphopyruvate hydratase activity
KME66_RS21215	COG1252	NADH dehydrogenase
KME66_RS21220	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KME66_RS21225	COG0577	efflux transmembrane transporter activity
KME66_RS21225	COG1136	(ABC) transporter
KME66_RS21230	COG1136	(ABC) transporter
KME66_RS21255	COG0183	Belongs to the thiolase family
KME66_RS21260	COG2755	lipolytic protein G-D-S-L family
KME66_RS21300	COG0531	amino acid
KME66_RS21305	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KME66_RS21320	COG1228	amidohydrolase
KME66_RS21325	COG1191	sigma factor activity
KME66_RS21330	COG1366	Belongs to the anti-sigma-factor antagonist family
KME66_RS21365	COG3104	oligopeptide transport
KME66_RS21370	COG0745	RESPONSE REGULATOR receiver
KME66_RS21375	COG2205	protein histidine kinase activity
KME66_RS21425	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KME66_RS21470	COG1316	TRANSCRIPTIONal
KME66_RS21480	COG1316	TRANSCRIPTIONal
KME66_RS21495	COG1316	TRANSCRIPTIONal
KME66_RS21500	COG1316	TRANSCRIPTIONal
KME66_RS21515	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KME66_RS21525	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
KME66_RS21525	COG0778	Nitroreductase
KME66_RS21530	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KME66_RS21565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KME66_RS21570	COG2835	tetraacyldisaccharide 4'-kinase activity
KME66_RS21590	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KME66_RS21630	COG0714	Associated with various cellular activities
KME66_RS21650	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KME66_RS21655	COG0745	RESPONSE REGULATOR receiver
KME66_RS21660	COG5000	phosphorelay sensor kinase activity
KME66_RS21660	COG5002	protein histidine kinase activity
KME66_RS21665	COG0823	Involved in the tonB-independent uptake of proteins
KME66_RS21675	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KME66_RS21680	COG2197	response regulator
KME66_RS21695	COG0653	protein targeting
KME66_RS21720	COG2902	Dehydrogenase
KME66_RS21725	COG1134	teichoic acid transport
KME66_RS21725	COG1388	LysM domain
KME66_RS21745	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KME66_RS21750	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KME66_RS21755	COG4122	O-methyltransferase activity
KME66_RS21760	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KME66_RS21765	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KME66_RS21770	COG0438	transferase activity, transferring glycosyl groups
KME66_RS21780	COG0395	ABC-type sugar transport system, permease component
KME66_RS21785	COG1175	transmembrane transport
KME66_RS21790	COG1653	transport
KME66_RS21800	COG0515	serine threonine protein kinase
KME66_RS21805	COG0515	serine threonine protein kinase
KME66_RS21810	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KME66_RS21825	COG2884	Cell division ATP-binding protein ftsE
KME66_RS21830	COG2177	Part of the ABC transporter FtsEX involved in
KME66_RS21835	COG0793	Belongs to the peptidase S41A family
KME66_RS21840	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KME66_RS21855	COG0583	DNA-binding transcription factor activity
KME66_RS21875	COG2223	nitrite transmembrane transporter activity
KME66_RS21910	COG3973	AAA domain
KME66_RS21910	COG3973	AAA domain
KME66_RS21920	COG0776	regulation of translation
KME66_RS21935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KME66_RS21940	COG1678	Uncharacterized ACR, COG1678
KME66_RS21960	COG0395	ABC-type sugar transport system, permease component
KME66_RS21965	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KME66_RS22015	COG2814	Major facilitator Superfamily
KME66_RS22055	COG3480	Lon protease (S16) C-terminal proteolytic domain
KME66_RS22080	COG1174	glycine betaine transport
KME66_RS22090	COG1174	glycine betaine transport
KME66_RS22100	COG3185	4-Hydroxyphenylpyruvate dioxygenase
KME66_RS22110	COG0277	FAD linked oxidase domain protein
KME66_RS22145	COG1335	isochorismatase
KME66_RS22155	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KME66_RS22165	COG1113	amino acid transport
KME66_RS22180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KME66_RS22210	COG1263	PTS System
KME66_RS22215	COG1263	PTS System
KME66_RS22220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KME66_RS22225	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KME66_RS22235	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KME66_RS22245	COG0477	Major facilitator Superfamily
KME66_RS22270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KME66_RS22285	COG4555	ABC transporter
KME66_RS22300	COG2733	membrane
KME66_RS22305	COG2267	carboxylic ester hydrolase activity
KME66_RS22310	COG2175	clavaminate synthase activity
KME66_RS22325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KME66_RS22330	COG3135	benzoate transporter
KME66_RS22370	COG3655	Transcriptional regulator
KME66_RS22405	COG3764	Sortase (surface protein transpeptidase)
KME66_RS22415	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
KME66_RS22415	COG0706	membrane insertase activity
KME66_RS22425	COG4702	Belongs to the UPF0303 family
KME66_RS22430	COG0673	inositol 2-dehydrogenase activity
KME66_RS22435	COG1940	carbohydrate kinase activity
KME66_RS22445	COG2188	Transcriptional regulator
KME66_RS22450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KME66_RS22530	COG3397	chitin binding
KME66_RS22535	COG0318	PFAM AMP-dependent synthetase and ligase
KME66_RS22570	COG1126	abc transporter atp-binding protein
KME66_RS22575	COG0765	amino acid transport
KME66_RS22580	COG0765	amino acid transport
KME66_RS22585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KME66_RS22605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KME66_RS22655	COG0588	phosphoglycerate mutase activity
KME66_RS22695	COG2985	domain, Protein
KME66_RS22700	COG2985	domain, Protein
KME66_RS22715	COG0395	ABC-type sugar transport system, permease component
KME66_RS22740	COG4977	sequence-specific DNA binding
KME66_RS22745	COG0589	response to stress
KME66_RS22750	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KME66_RS22775	COG3486	L-lysine 6-monooxygenase (NADPH) activity
KME66_RS22780	COG0076	glutamate decarboxylase activity
KME66_RS22785	COG1960	acyl-CoA dehydrogenase activity
KME66_RS22800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KME66_RS22805	COG1309	transcriptional regulator
KME66_RS22815	COG1278	Cold shock
KME66_RS22840	COG1946	Acyl-CoA thioesterase
KME66_RS22845	COG1960	acyl-CoA dehydrogenase activity
KME66_RS22860	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KME66_RS22925	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KME66_RS22935	COG0028	Belongs to the TPP enzyme family
KME66_RS22960	COG1472	Belongs to the glycosyl hydrolase 3 family
KME66_RS22965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KME66_RS22970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KME66_RS22980	COG1028	Short-chain dehydrogenase reductase Sdr
KME66_RS22985	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KME66_RS23020	COG1404	Belongs to the peptidase S8 family
KME66_RS23055	COG0515	serine threonine protein kinase
KME66_RS23080	COG1609	Transcriptional regulator
KME66_RS23085	COG0673	inositol 2-dehydrogenase activity
KME66_RS23135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KME66_RS23140	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KME66_RS23170	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KME66_RS23175	COG2255	four-way junction helicase activity
KME66_RS23220	COG0596	Alpha beta hydrolase
KME66_RS23240	COG2197	response regulator
KME66_RS23245	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KME66_RS23270	COG2409	Drug exporters of the RND superfamily
KME66_RS23285	COG2318	DinB family
KME66_RS23295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KME66_RS23305	COG3718	enzyme involved in inositol metabolism
KME66_RS23310	COG3962	Belongs to the TPP enzyme family
KME66_RS23330	COG1131	(ABC) transporter
KME66_RS23360	COG4585	Histidine kinase
KME66_RS23365	COG2197	response regulator
KME66_RS23395	COG0629	single-stranded DNA binding
KME66_RS23425	COG1136	(ABC) transporter
KME66_RS23425	COG0577	efflux transmembrane transporter activity
KME66_RS23440	COG2346	COG2346, Truncated hemoglobins
KME66_RS23475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KME66_RS23490	COG1486	melibiose metabolic process
KME66_RS23495	COG0395	ABC-type sugar transport system, permease component
KME66_RS23500	COG1175	transmembrane transport
KME66_RS23510	COG1940	carbohydrate kinase activity
KME66_RS23515	COG0668	transmembrane transport
KME66_RS23525	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KME66_RS23525	COG3291	Pkd domain containing protein
KME66_RS23550	COG4266	Belongs to the allantoicase family
KME66_RS23595	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KME66_RS23605	COG2252	PERMEase
KME66_RS23640	COG0110	maltose O-acetyltransferase activity
KME66_RS23650	COG0640	Transcriptional regulator
KME66_RS23655	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KME66_RS23660	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KME66_RS23665	COG0584	glycerophosphoryl diester phosphodiesterase
KME66_RS23670	COG1113	amino acid transport
KME66_RS23675	COG1113	amino acid transport
KME66_RS23680	COG1268	BioY protein
KME66_RS23685	COG1113	amino acid transport
KME66_RS23705	COG0475	glutathione-regulated potassium exporter activity
KME66_RS23715	COG3594	Acyltransferase
KME66_RS23735	COG0544	peptidyl-prolyl cis-trans isomerase activity
KME66_RS23740	COG0740	serine-type endopeptidase activity
KME66_RS23745	COG0740	serine-type endopeptidase activity
KME66_RS23750	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KME66_RS23760	COG0525	valine-tRNA ligase activity
KME66_RS23765	COG0285	dihydrofolate synthase activity
KME66_RS23775	COG0105	UTP biosynthetic process
KME66_RS23780	COG1077	Cell shape determining protein MreB Mrl
KME66_RS23795	COG0768	penicillin binding
KME66_RS23800	COG0772	Belongs to the SEDS family
KME66_RS23830	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KME66_RS23835	COG0673	inositol 2-dehydrogenase activity
KME66_RS23855	COG0438	transferase activity, transferring glycosyl groups
KME66_RS23870	COG0438	transferase activity, transferring glycosyl groups
KME66_RS23890	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KME66_RS23895	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KME66_RS23900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KME66_RS23920	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KME66_RS23925	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KME66_RS23935	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KME66_RS23950	COG0501	Belongs to the peptidase M48B family
KME66_RS23965	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KME66_RS23975	COG0799	negative regulation of ribosome biogenesis
KME66_RS23980	COG0588	phosphoglycerate mutase activity
KME66_RS24000	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KME66_RS24010	COG0495	leucyl-tRNA aminoacylation
KME66_RS24020	COG1307	EDD domain protein, DegV family
KME66_RS24025	COG1555	photosystem II stabilization
KME66_RS24150	COG0268	Binds directly to 16S ribosomal RNA
KME66_RS24155	COG0481	GTPase activity
KME66_RS24165	COG0738	Major facilitator superfamily
KME66_RS24200	COG1420	regulation of RNA biosynthetic process
KME66_RS24205	COG0484	heat shock protein binding
KME66_RS24210	COG2070	2-Nitropropane dioxygenase
KME66_RS24220	COG0537	adenosine 5'-monophosphoramidase activity
KME66_RS24225	COG1234	tRNA 3'-trailer cleavage
KME66_RS24230	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KME66_RS24240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KME66_RS24250	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KME66_RS24260	COG2315	Protein conserved in bacteria
KME66_RS24265	COG0604	alcohol dehydrogenase
KME66_RS24265	COG3321	synthase
KME66_RS24265	COG1028	Short-chain dehydrogenase reductase Sdr
KME66_RS24275	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KME66_RS24290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KME66_RS24300	COG1381	Involved in DNA repair and RecF pathway recombination
KME66_RS24305	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KME66_RS24315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KME66_RS24320	COG1121	(ABC) transporter
KME66_RS24330	COG0423	glycine-tRNA ligase activity
KME66_RS24400	COG0574	Belongs to the PEP-utilizing enzyme family
KME66_RS24400	COG3848	Pyruvate phosphate dikinase
KME66_RS24415	COG2066	Belongs to the glutaminase family
KME66_RS24470	COG0477	Major facilitator Superfamily
KME66_RS24485	COG2188	Transcriptional regulator
KME66_RS24505	COG3842	ATPase activity
KME66_RS24515	COG0574	Belongs to the PEP-utilizing enzyme family
KME66_RS24515	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KME66_RS24540	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KME66_RS24540	COG2146	nitrite reductase [NAD(P)H] activity
KME66_RS24595	COG0232	Belongs to the dGTPase family. Type 2 subfamily
KME66_RS24605	COG0358	DNA primase activity
KME66_RS24610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KME66_RS24625	COG1070	Carbohydrate kinase
KME66_RS24710	COG0477	Major facilitator Superfamily
KME66_RS24715	COG0825	malonyl-CoA metabolic process
KME66_RS24715	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KME66_RS24720	COG0318	PFAM AMP-dependent synthetase and ligase
KME66_RS24735	COG1522	sequence-specific DNA binding
KME66_RS24760	COG2130	NADP-dependent
KME66_RS24765	COG1764	response to oxidative stress
KME66_RS24785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KME66_RS24790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KME66_RS24795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KME66_RS24810	COG1741	Belongs to the pirin family
KME66_RS24845	COG1929	Belongs to the glycerate kinase type-1 family
KME66_RS24855	COG0745	RESPONSE REGULATOR receiver
KME66_RS24860	COG2205	protein histidine kinase activity
KME66_RS24870	COG0789	Transcriptional regulator
KME66_RS24875	COG0667	Aldo Keto reductase
KME66_RS24890	COG2197	response regulator
KME66_RS24895	COG4585	Histidine kinase
KME66_RS24910	COG1309	transcriptional regulator
KME66_RS24915	COG0477	Major facilitator Superfamily
KME66_RS24925	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
KME66_RS24970	COG1358	cellular component organization or biogenesis
KME66_RS25065	COG2259	Doxx family
KME66_RS25110	COG2124	cytochrome p450
KME66_RS25115	COG0183	Belongs to the thiolase family
KME66_RS25145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KME66_RS25205	COG1309	transcriptional regulator
KME66_RS25210	COG0438	transferase activity, transferring glycosyl groups
KME66_RS25235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KME66_RS25245	COG0860	N-Acetylmuramoyl-L-alanine amidase
KME66_RS25260	COG0183	Belongs to the thiolase family
KME66_RS25270	COG2030	dehydratase
KME66_RS25280	COG1028	Short-chain dehydrogenase reductase Sdr
KME66_RS25285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KME66_RS25290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KME66_RS25300	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KME66_RS25315	COG0800	Aldolase
KME66_RS25320	COG3022	response to hydroperoxide
KME66_RS25370	COG0384	phenazine biosynthesis protein PhzF
KME66_RS25375	COG1028	Short-chain dehydrogenase reductase Sdr
KME66_RS25380	COG3540	Alkaline phosphatase
KME66_RS25390	COG2814	Major facilitator Superfamily
KME66_RS25410	COG1834	amidinotransferase
KME66_RS25430	COG1120	ATPase activity
KME66_RS25435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KME66_RS25500	COG1994	Peptidase M50
KME66_RS25520	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KME66_RS25525	COG0477	Major facilitator Superfamily
KME66_RS25540	COG2814	Major facilitator Superfamily
KME66_RS25545	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KME66_RS25545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KME66_RS25550	COG2132	Multicopper oxidase
KME66_RS25570	COG0174	glutamine synthetase
KME66_RS25595	COG2890	protein-(glutamine-N5) methyltransferase activity
KME66_RS25600	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KME66_RS25625	COG1609	Transcriptional regulator
KME66_RS25640	COG0395	ABC-type sugar transport system, permease component
KME66_RS25645	COG0366	Alpha amylase catalytic
KME66_RS25690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KME66_RS25715	COG2197	response regulator
KME66_RS25720	COG4585	Histidine kinase
KME66_RS25725	COG0745	RESPONSE REGULATOR receiver
KME66_RS25750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KME66_RS25755	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KME66_RS25805	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KME66_RS25810	COG0321	lipoyl(octanoyl) transferase activity
KME66_RS25850	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
KME66_RS25865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KME66_RS25870	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KME66_RS25875	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
KME66_RS25890	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KME66_RS25915	COG1028	Short-chain dehydrogenase reductase Sdr
KME66_RS25930	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KME66_RS25940	COG1410	methionine synthase
KME66_RS25940	COG0646	methionine synthase
KME66_RS25945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KME66_RS25955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KME66_RS25960	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KME66_RS25970	COG1131	(ABC) transporter
KME66_RS25990	COG5002	protein histidine kinase activity
KME66_RS25995	COG0745	RESPONSE REGULATOR receiver
KME66_RS26000	COG4585	Histidine kinase
KME66_RS26020	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
KME66_RS26020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KME66_RS26020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KME66_RS26020	COG3321	synthase
KME66_RS26030	COG3321	synthase
KME66_RS26030	COG0300	oxidoreductase activity
KME66_RS26030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KME66_RS26030	COG4221	oxidoreductase activity
KME66_RS26035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KME66_RS26035	COG3321	synthase
KME66_RS26035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KME66_RS26035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KME66_RS26035	COG1028	Short-chain dehydrogenase reductase Sdr
KME66_RS26045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KME66_RS26045	COG0300	oxidoreductase activity
KME66_RS26045	COG3321	synthase
KME66_RS26045	COG4221	oxidoreductase activity
KME66_RS26055	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KME66_RS26055	COG2070	2-Nitropropane dioxygenase
KME66_RS26075	COG1510	regulation of RNA biosynthetic process
KME66_RS26095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KME66_RS26120	COG4585	Histidine kinase
KME66_RS26125	COG2197	response regulator
KME66_RS26130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KME66_RS26140	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KME66_RS26160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KME66_RS26165	COG1104	cysteine desulfurase activity
KME66_RS26170	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KME66_RS26175	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KME66_RS26185	COG1376	ErfK ybiS ycfS ynhG family protein
KME66_RS26195	COG1845	cytochrome c oxidase, subunit III
KME66_RS26200	COG2010	Cytochrome c
KME66_RS26205	COG0723	plastoquinol--plastocyanin reductase activity
KME66_RS26210	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KME66_RS26215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KME66_RS26220	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KME66_RS26265	COG0438	transferase activity, transferring glycosyl groups
KME66_RS26285	COG0003	Pfam Anion-transporting ATPase
KME66_RS26295	COG1940	carbohydrate kinase activity
KME66_RS26330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KME66_RS26345	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
KME66_RS26355	COG2193	ferroxidase activity
KME66_RS26360	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KME66_RS26365	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KME66_RS26370	COG2815	serine threonine protein kinase
KME66_RS26370	COG0515	serine threonine protein kinase
KME66_RS26375	COG2022	thiamine diphosphate biosynthetic process
KME66_RS26385	COG2022	thiamine diphosphate biosynthetic process
KME66_RS26385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KME66_RS26405	COG0352	thiamine-phosphate diphosphorylase activity
KME66_RS26420	COG1233	COG1233 Phytoene dehydrogenase and related
KME66_RS26430	COG1309	transcriptional regulator
KME66_RS26440	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
KME66_RS26450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KME66_RS26470	COG0714	Associated with various cellular activities
KME66_RS26480	COG0275	rRNA processing
KME66_RS26490	COG0768	penicillin binding
KME66_RS26495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KME66_RS26505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KME66_RS26510	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KME66_RS26520	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KME66_RS26540	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KME66_RS26545	COG1799	cell septum assembly
KME66_RS26555	COG3599	regulation of cell shape
KME66_RS26560	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KME66_RS26570	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KME66_RS26620	COG0587	DNA-directed DNA polymerase activity
KME66_RS26630	COG1432	Conserved Protein
KME66_RS26670	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KME66_RS26675	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KME66_RS26680	COG0131	Imidazoleglycerol-phosphate dehydratase
KME66_RS26690	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KME66_RS26695	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KME66_RS26700	COG0251	oxidation-reduction process
KME66_RS26705	COG0107	imidazoleglycerol-phosphate synthase activity
KME66_RS26720	COG2508	Transcriptional regulator
KME66_RS26730	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KME66_RS26735	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KME66_RS26755	COG0134	indole-3-glycerol-phosphate synthase activity
KME66_RS26765	COG0133	tryptophan synthase activity
KME66_RS26770	COG0159	tryptophan synthase activity
KME66_RS26780	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KME66_RS26810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KME66_RS26820	COG0070	glutamate synthase
KME66_RS26820	COG0069	glutamate synthase activity
KME66_RS26820	COG0067	glutamate synthase
KME66_RS26830	COG0705	Rhomboid family
KME66_RS26835	COG2304	oxidoreductase activity
KME66_RS26855	COG1960	acyl-CoA dehydrogenase activity
KME66_RS26860	COG1960	acyl-CoA dehydrogenase activity
KME66_RS26865	COG1028	Short-chain dehydrogenase reductase Sdr
KME66_RS26870	COG1309	transcriptional regulator
KME66_RS26875	COG0183	Belongs to the thiolase family
KME66_RS26880	COG1278	Cold shock
KME66_RS26905	COG1024	Enoyl-CoA hydratase
KME66_RS26910	COG1028	Short-chain dehydrogenase reductase Sdr
KME66_RS26940	COG1605	Chorismate mutase
KME66_RS26940	COG0287	Prephenate dehydrogenase
KME66_RS26970	COG0737	Belongs to the 5'-nucleotidase family
KME66_RS27025	COG2050	protein possibly involved in aromatic compounds catabolism
KME66_RS27080	COG1643	Atp-dependent helicase
KME66_RS27085	COG2226	methyltransferase
KME66_RS27105	COG0237	dephospho-CoA kinase activity
KME66_RS27135	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KME66_RS27145	COG0436	Aminotransferase
KME66_RS27165	COG2313	pseudouridylate synthase activity
KME66_RS27185	COG0584	glycerophosphoryl diester phosphodiesterase
KME66_RS27195	COG0556	nucleotide-excision repair
KME66_RS27225	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KME66_RS27250	COG0322	excinuclease ABC activity
KME66_RS27255	COG1660	Displays ATPase and GTPase activities
KME66_RS27260	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KME66_RS27265	COG1481	regulation of sporulation
KME66_RS27270	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KME66_RS27275	COG0126	phosphoglycerate kinase activity
KME66_RS27280	COG0149	triose-phosphate isomerase activity
KME66_RS27285	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KME66_RS27295	COG0166	Belongs to the GPI family
KME66_RS27310	COG4195	phage-related replication protein
KME66_RS27335	COG0363	glucosamine-6-phosphate deaminase activity
KME66_RS27350	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KME66_RS27360	COG0109	protoheme IX farnesyltransferase activity
KME66_RS27400	COG0719	Fe-S assembly protein
KME66_RS27410	COG0396	ATPase activity
KME66_RS27415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KME66_RS27420	COG0822	iron-sulfur transferase activity
KME66_RS27425	COG2151	metal-sulfur cluster biosynthetic enzyme
KME66_RS27440	COG3226	Transcriptional regulator
KME66_RS27455	COG2171	N-acyltransferase activity
KME66_RS27460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KME66_RS27500	COG0768	penicillin binding
KME66_RS27515	COG1414	Transcriptional regulator
KME66_RS27545	COG1902	pentaerythritol trinitrate reductase activity
KME66_RS27575	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KME66_RS27600	COG1797	cobyrinic acid a,c-diamide synthase activity
KME66_RS27615	COG1492	cobalamin metabolic process
KME66_RS27620	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
KME66_RS27635	COG0235	Class ii aldolase
KME66_RS27655	COG0488	(ABC) transporter
KME66_RS27665	COG1024	Enoyl-CoA hydratase
KME66_RS27705	COG3387	PFAM Glycoside hydrolase 15-related
KME66_RS27720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KME66_RS27720	COG1199	ATP-dependent helicase activity
KME66_RS27745	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KME66_RS27750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KME66_RS27765	COG2261	transglycosylase associated protein
KME66_RS27770	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KME66_RS27785	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
KME66_RS27795	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KME66_RS27800	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KME66_RS27810	COG1028	Short-chain dehydrogenase reductase Sdr
KME66_RS27815	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KME66_RS27825	COG2186	Transcriptional regulator
KME66_RS27845	COG0560	Phosphoserine phosphatase
KME66_RS27845	COG3830	Belongs to the UPF0237 family
KME66_RS27850	COG0842	Transport permease protein
KME66_RS27850	COG1131	(ABC) transporter
KME66_RS27850	COG1716	ATPase activity
KME66_RS27860	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KME66_RS27865	COG1028	Short-chain dehydrogenase reductase Sdr
KME66_RS27875	COG2197	response regulator
KME66_RS27890	COG1119	ATPase activity
KME66_RS27915	COG1881	PFAM PEBP family protein
KME66_RS27925	COG2094	Belongs to the DNA glycosylase MPG family
KME66_RS27960	COG0647	UMP catabolic process
KME66_RS27965	COG1120	ATPase activity
KME66_RS27985	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KME66_RS27990	COG0497	DNA recombination
KME66_RS28005	COG3387	PFAM Glycoside hydrolase 15-related
KME66_RS28010	COG0504	CTP synthase activity
KME66_RS28015	COG0494	nUDIX hydrolase
KME66_RS28025	COG0686	Belongs to the AlaDH PNT family
KME66_RS28040	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KME66_RS28045	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KME66_RS28095	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KME66_RS28105	COG1160	GTP binding
KME66_RS28120	COG0438	transferase activity, transferring glycosyl groups
KME66_RS28135	COG0671	phosphoesterase, PA-phosphatase related
KME66_RS28140	COG0477	Major facilitator Superfamily
KME66_RS28145	COG1960	acyl-CoA dehydrogenase activity
KME66_RS28150	COG1799	cell septum assembly
KME66_RS28230	COG0346	lactoylglutathione lyase activity
KME66_RS28245	COG1725	Transcriptional regulator
KME66_RS28255	COG2755	lipolytic protein G-D-S-L family
KME66_RS28265	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KME66_RS28275	COG2188	Transcriptional regulator
KME66_RS28280	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
KME66_RS28285	COG1309	transcriptional regulator
KME66_RS28290	COG0243	molybdopterin cofactor binding
KME66_RS28295	COG2851	Citrate transporter
KME66_RS28300	COG2318	DinB family
KME66_RS28315	COG2326	polyphosphate kinase activity
KME66_RS28330	COG1960	acyl-CoA dehydrogenase activity
KME66_RS28350	COG0789	Transcriptional regulator
KME66_RS28365	COG3876	Protein conserved in bacteria
KME66_RS28375	COG0318	PFAM AMP-dependent synthetase and ligase
KME66_RS28385	COG4935	Belongs to the peptidase S8 family
KME66_RS28385	COG2234	aminopeptidase activity
KME66_RS28390	COG1960	acyl-CoA dehydrogenase activity
KME66_RS28410	COG2149	membrane
KME66_RS28415	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
KME66_RS28420	COG3573	Dehydrogenase
KME66_RS28445	COG3265	gluconokinase activity
KME66_RS28450	COG2186	Transcriptional regulator
KME66_RS28460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KME66_RS28465	COG0564	pseudouridine synthase activity
KME66_RS28475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KME66_RS28505	COG0667	Aldo Keto reductase
KME66_RS28510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KME66_RS28520	COG0598	Magnesium transport protein CorA
KME66_RS28540	COG0215	cysteine-tRNA ligase activity
KME66_RS28555	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KME66_RS28560	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KME66_RS28565	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KME66_RS28570	COG1414	Transcriptional regulator
KME66_RS28575	COG1410	methionine synthase
KME66_RS28575	COG0646	methionine synthase
KME66_RS28580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KME66_RS28585	COG0747	negative chemotaxis
KME66_RS28590	COG2197	response regulator
KME66_RS28600	COG1994	Peptidase M50
KME66_RS28600	COG0517	IMP dehydrogenase activity
KME66_RS28620	COG1222	aaa ATPase
KME66_RS28625	COG4122	O-methyltransferase activity
KME66_RS28635	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
KME66_RS28640	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
KME66_RS28645	COG1609	Transcriptional regulator
KME66_RS28655	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
KME66_RS28660	COG0545	Peptidyl-prolyl cis-trans isomerase
KME66_RS28670	COG2378	regulation of single-species biofilm formation
KME66_RS28690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KME66_RS28695	COG0805	protein transport
KME66_RS28715	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
KME66_RS28730	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KME66_RS28735	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KME66_RS28780	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KME66_RS28785	COG4175	Glycine betaine
KME66_RS28785	COG0517	IMP dehydrogenase activity
KME66_RS28825	COG1404	Belongs to the peptidase S8 family
KME66_RS28835	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KME66_RS28845	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KME66_RS28850	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KME66_RS28855	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KME66_RS28860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KME66_RS28865	COG5002	protein histidine kinase activity
KME66_RS28870	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KME66_RS28875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KME66_RS28875	COG0072	phenylalanine-tRNA ligase activity
KME66_RS28885	COG0494	nUDIX hydrolase
KME66_RS28895	COG1649	PFAM Uncharacterised BCR, COG1649
KME66_RS28905	COG0697	spore germination
KME66_RS28920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KME66_RS28975	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KME66_RS28980	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KME66_RS28985	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KME66_RS28990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KME66_RS28995	COG1438	arginine binding
KME66_RS29010	COG0137	argininosuccinate synthase activity
KME66_RS29015	COG0165	Argininosuccinate lyase
KME66_RS29030	COG0477	Major facilitator Superfamily
KME66_RS29070	COG2011	ABC-type metal ion transport system permease component
KME66_RS29075	COG1464	Belongs to the NlpA lipoprotein family
KME66_RS29095	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KME66_RS29095	COG1648	precorrin-2 dehydrogenase activity
KME66_RS29150	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KME66_RS29160	COG0454	-acetyltransferase
KME66_RS29160	COG0456	acetyltransferase
KME66_RS29210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KME66_RS29225	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KME66_RS29250	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KME66_RS29255	COG1560	Kdo2-lipid A biosynthetic process
KME66_RS29260	COG0438	transferase activity, transferring glycosyl groups
KME66_RS29270	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
KME66_RS29275	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
KME66_RS29280	COG0217	transcriptional regulatory protein
KME66_RS29285	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KME66_RS29290	COG0632	four-way junction helicase activity
KME66_RS29295	COG2255	four-way junction helicase activity
KME66_RS29305	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KME66_RS29310	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KME66_RS29315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KME66_RS29325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KME66_RS29330	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KME66_RS29340	COG1196	nuclear chromosome segregation
KME66_RS29355	COG0124	histidyl-tRNA synthetase
KME66_RS29360	COG2197	response regulator
KME66_RS29395	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KME66_RS29415	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KME66_RS29420	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KME66_RS29430	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KME66_RS29435	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KME66_RS29440	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KME66_RS29445	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KME66_RS29455	COG0006	proline dipeptidase activity
KME66_RS29460	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KME66_RS29465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KME66_RS29475	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KME66_RS29480	COG0540	Belongs to the ATCase OTCase family
KME66_RS29485	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KME66_RS29495	COG0505	Belongs to the CarA family
KME66_RS29500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KME66_RS29505	COG0167	dihydroorotate dehydrogenase activity
KME66_RS29510	COG0284	orotidine-5'-phosphate decarboxylase activity
KME66_RS29525	COG1758	RNA polymerase activity
KME66_RS29535	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KME66_RS29540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KME66_RS29550	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KME66_RS29560	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KME66_RS29565	COG2390	Transcriptional regulator
KME66_RS29580	COG1012	belongs to the aldehyde dehydrogenase family
KME66_RS29590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KME66_RS29610	COG2233	PERMEase
KME66_RS29615	COG0738	Major facilitator superfamily
KME66_RS29640	COG3201	nicotinamide mononucleotide transporter
KME66_RS29645	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KME66_RS29645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KME66_RS29650	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KME66_RS29655	COG0140	phosphoribosyl-ATP diphosphatase activity
KME66_RS29660	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KME66_RS29715	COG1131	(ABC) transporter
KME66_RS29735	COG1960	acyl-CoA dehydrogenase activity
KME66_RS29755	COG1216	Glycosyl transferase, family 2
KME66_RS29760	COG3030	protein affecting phage T7 exclusion by the F plasmid
KME66_RS29770	COG2270	Major facilitator Superfamily
KME66_RS29780	COG2364	Membrane
KME66_RS29840	COG2018	Roadblock/LC7 domain
KME66_RS29870	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
KME66_RS29885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KME66_RS29895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KME66_RS29925	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KME66_RS29945	COG1716	ATPase activity
KME66_RS29965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KME66_RS29975	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KME66_RS29975	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KME66_RS30010	COG0384	phenazine biosynthesis protein PhzF
KME66_RS30030	COG1695	Transcriptional regulator
KME66_RS30070	COG0697	spore germination
KME66_RS30075	COG0583	DNA-binding transcription factor activity
KME66_RS30135	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KME66_RS30210	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KME66_RS30215	COG2226	methyltransferase
KME66_RS30220	COG0243	molybdopterin cofactor binding
KME66_RS30285	COG1968	undecaprenyl-diphosphatase activity
KME66_RS30320	COG1968	undecaprenyl-diphosphatase activity
KME66_RS30335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KME66_RS30380	COG1832	CoA-binding protein
KME66_RS30385	COG1739	Uncharacterized protein family UPF0029
KME66_RS30390	COG0420	3'-5' exonuclease activity
KME66_RS30395	COG0419	ATPase involved in DNA repair
KME66_RS30400	COG1522	sequence-specific DNA binding
KME66_RS30420	COG0626	cystathionine gamma-synthase activity
KME66_RS30435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KME66_RS30450	COG1595	DNA-templated transcription, initiation
KME66_RS30455	COG2188	Transcriptional regulator
KME66_RS30460	COG1940	carbohydrate kinase activity
KME66_RS30470	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KME66_RS30490	COG0456	acetyltransferase
KME66_RS30510	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KME66_RS30515	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KME66_RS30520	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KME66_RS30525	COG0156	8-amino-7-oxononanoate synthase activity
KME66_RS30545	COG0583	DNA-binding transcription factor activity
KME66_RS30550	COG1280	lysine exporter protein (LysE YggA)
KME66_RS30565	COG0740	serine-type endopeptidase activity
KME66_RS30580	COG1309	transcriptional regulator
KME66_RS30585	COG0831	urea catabolic process
KME66_RS30590	COG0832	Belongs to the urease beta subunit family
KME66_RS30595	COG0804	urea catabolic process
KME66_RS30605	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KME66_RS30610	COG0829	nickel cation binding
KME66_RS30625	COG0204	Acyl-transferase
KME66_RS30640	COG0205	6-phosphofructokinase activity
KME66_RS30645	COG3442	glutamine amidotransferase
KME66_RS30655	COG0242	peptide deformylase activity
KME66_RS30665	COG1960	acyl-CoA dehydrogenase activity
KME66_RS30670	COG0386	Belongs to the glutathione peroxidase family
KME66_RS30695	COG1946	Acyl-CoA thioesterase
KME66_RS30710	COG1793	dna ligase
KME66_RS30715	COG1252	NADH dehydrogenase
KME66_RS30725	COG1132	(ABC) transporter
KME66_RS30730	COG1132	(ABC) transporter
KME66_RS30740	COG0277	FAD linked oxidase domain protein
KME66_RS30745	COG1846	Transcriptional regulator
KME66_RS30750	COG1132	(ABC) transporter
KME66_RS30755	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KME66_RS30770	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KME66_RS30790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KME66_RS30850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KME66_RS30870	COG0464	growth
KME66_RS30875	COG1404	Belongs to the peptidase S8 family
KME66_RS30880	COG1674	ftsk spoiiie
KME66_RS30900	COG4842	Belongs to the WXG100 family
KME66_RS30970	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KME66_RS30975	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
KME66_RS31025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KME66_RS31045	COG2080	2 iron, 2 sulfur cluster binding
KME66_RS31050	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
KME66_RS31055	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KME66_RS31075	COG2890	protein-(glutamine-N5) methyltransferase activity
KME66_RS31130	COG0542	response to heat
KME66_RS31155	COG3547	Transposase (IS116 IS110 IS902 family)
KME66_RS31215	COG0402	S-adenosylhomocysteine deaminase activity
KME66_RS31230	COG2835	tetraacyldisaccharide 4'-kinase activity
KME66_RS31250	COG4981	capsule polysaccharide biosynthetic process
KME66_RS31285	COG1012	belongs to the aldehyde dehydrogenase family
KME66_RS31290	COG0174	glutamine synthetase
KME66_RS31300	COG0531	amino acid
KME66_RS31305	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KME66_RS31340	COG1253	flavin adenine dinucleotide binding
KME66_RS31360	COG0667	Aldo Keto reductase
KME66_RS31365	COG0515	serine threonine protein kinase
KME66_RS31365	COG2815	serine threonine protein kinase
KME66_RS31400	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KME66_RS31435	COG4221	oxidoreductase activity
KME66_RS31490	COG2706	6-phosphogluconolactonase activity
KME66_RS31505	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KME66_RS31525	COG0493	'glutamate synthase
KME66_RS31550	COG0671	phosphoesterase, PA-phosphatase related
KME66_RS31570	COG0584	glycerophosphoryl diester phosphodiesterase
KME66_RS31615	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KME66_RS31640	COG1940	carbohydrate kinase activity
KME66_RS31650	COG1660	Displays ATPase and GTPase activities
KME66_RS31665	COG0445	tRNA wobble uridine modification
KME66_RS31685	COG1940	carbohydrate kinase activity
KME66_RS31710	COG0702	epimerase
KME66_RS31725	COG1349	DNA-binding transcription factor activity
KME66_RS31735	COG0464	growth
KME66_RS31765	COG5000	phosphorelay sensor kinase activity
KME66_RS31765	COG5002	protein histidine kinase activity
KME66_RS31850	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KME66_RS31860	COG1132	(ABC) transporter
KME66_RS31865	COG0328	RNA-DNA hybrid ribonuclease activity
KME66_RS31905	COG0515	serine threonine protein kinase
KME66_RS31905	COG2815	serine threonine protein kinase
KME66_RS31915	COG1131	(ABC) transporter
KME66_RS31915	COG0842	Transport permease protein
KME66_RS31915	COG1716	ATPase activity
KME66_RS31925	COG3250	beta-galactosidase activity
KME66_RS31940	COG1879	ABC-type sugar transport system periplasmic component
KME66_RS31945	COG1129	ABC transporter
KME66_RS31955	COG1172	Belongs to the binding-protein-dependent transport system permease family
KME66_RS31960	COG1609	Transcriptional regulator
KME66_RS31975	COG2837	iron assimilation
KME66_RS32010	COG1959	2 iron, 2 sulfur cluster binding
KME66_RS32010	COG1295	ribonuclease BN
KME66_RS32055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KME66_RS32090	COG1250	3-hydroxyacyl-CoA dehydrogenase
KME66_RS32095	COG3246	L-lysine catabolic process to acetate
KME66_RS32100	COG1309	transcriptional regulator
KME66_RS32105	COG1191	sigma factor activity
KME66_RS32145	COG1461	Dihydroxyacetone kinase
KME66_RS32150	COG2376	Dihydroxyacetone kinase
KME66_RS32165	COG0640	Transcriptional regulator
KME66_RS32180	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KME66_RS32210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KME66_RS32230	COG2015	COG2015, Alkyl sulfatase and related hydrolases
KME66_RS32290	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KME66_RS32360	COG0698	ribose 5-phosphate isomerase
KME66_RS32365	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KME66_RS32370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KME66_RS32655	COG3540	Alkaline phosphatase
KME66_RS32705	COG1028	Short-chain dehydrogenase reductase Sdr
KME66_RS32710	COG1302	Protein conserved in bacteria
KME66_RS32715	COG0587	DNA-directed DNA polymerase activity
KME66_RS32720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KME66_RS32730	COG1131	(ABC) transporter
KME66_RS32735	COG3559	Exporter of polyketide antibiotics
KME66_RS32765	COG0745	RESPONSE REGULATOR receiver
KME66_RS32770	COG5002	protein histidine kinase activity
KME66_RS32785	COG3486	L-lysine 6-monooxygenase (NADPH) activity
KME66_RS32790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KME66_RS32795	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KME66_RS32800	COG1120	ATPase activity
KME66_RS32805	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KME66_RS32820	COG1132	(ABC) transporter
KME66_RS32825	COG2382	esterase
KME66_RS32835	COG0148	phosphopyruvate hydratase activity
KME66_RS32890	COG2365	Tyrosine phosphatase family
KME66_RS32945	COG2080	2 iron, 2 sulfur cluster binding
KME66_RS32950	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
KME66_RS32955	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KME66_RS32965	COG1012	belongs to the aldehyde dehydrogenase family
KME66_RS32970	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
KME66_RS32975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KME66_RS32995	COG2066	Belongs to the glutaminase family
KME66_RS32995	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
KME66_RS33000	COG2356	endonuclease I
KME66_RS33015	COG2813	Specifically methylates the guanine in position
KME66_RS33020	COG1960	acyl-CoA dehydrogenase activity
KME66_RS33035	COG0515	serine threonine protein kinase
KME66_RS33050	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KME66_RS33055	COG2070	2-Nitropropane dioxygenase
KME66_RS33075	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KME66_RS33080	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KME66_RS33085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KME66_RS33105	COG0318	PFAM AMP-dependent synthetase and ligase
KME66_RS33125	COG1024	Enoyl-CoA hydratase
KME66_RS33175	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KME66_RS33180	COG0254	rRNA binding
KME66_RS33210	COG2318	DinB family
KME66_RS33240	COG0596	Alpha beta hydrolase
KME66_RS33255	COG0681	Belongs to the peptidase S26 family
KME66_RS33300	COG1653	transport
KME66_RS33305	COG1175	transmembrane transport
KME66_RS33310	COG0395	ABC-type sugar transport system, permease component
KME66_RS33315	COG0366	Alpha amylase catalytic
KME66_RS33340	COG0583	DNA-binding transcription factor activity
KME66_RS33370	COG0702	epimerase
KME66_RS33380	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KME66_RS33390	COG1064	alcohol dehydrogenase
KME66_RS33440	COG1764	response to oxidative stress
KME66_RS33445	COG1846	Transcriptional regulator
KME66_RS33460	COG4941	Belongs to the sigma-70 factor family
KME66_RS33465	COG3795	YCII-related domain
KME66_RS33525	COG1595	DNA-templated transcription, initiation
KME66_RS33530	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KME66_RS33585	COG4977	sequence-specific DNA binding
KME66_RS34005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KME66_RS34180	COG0745	RESPONSE REGULATOR receiver
KME66_RS34190	COG1028	Short-chain dehydrogenase reductase Sdr
KME66_RS34190	COG0300	oxidoreductase activity
KME66_RS34190	COG0318	PFAM AMP-dependent synthetase and ligase
KME66_RS34190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KME66_RS34190	COG3321	synthase