locus-tag	class	description
HJD23_RS00075	COG1302	Protein conserved in bacteria
HJD23_RS00090	COG0484	heat shock protein binding
HJD23_RS00130	COG0318	PFAM AMP-dependent synthetase and ligase
HJD23_RS00220	COG2801	Transposase and inactivated derivatives
HJD23_RS00230	COG2801	Transposase and inactivated derivatives
HJD23_RS00235	COG3385	transposase activity
HJD23_RS00245	COG2801	Transposase and inactivated derivatives
HJD23_RS00255	COG2197	response regulator
HJD23_RS00270	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HJD23_RS00305	COG3962	Belongs to the TPP enzyme family
HJD23_RS00315	COG0579	oxidoreductase
HJD23_RS00320	COG1012	belongs to the aldehyde dehydrogenase family
HJD23_RS00345	COG1126	abc transporter atp-binding protein
HJD23_RS00365	COG2271	Major facilitator Superfamily
HJD23_RS00375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HJD23_RS00390	COG1902	pentaerythritol trinitrate reductase activity
HJD23_RS00390	COG0446	pyridine nucleotide-disulphide oxidoreductase
HJD23_RS00395	COG3938	Belongs to the proline racemase family
HJD23_RS00410	COG2267	carboxylic ester hydrolase activity
HJD23_RS00435	COG0583	DNA-binding transcription factor activity
HJD23_RS00440	COG4608	Belongs to the ABC transporter superfamily
HJD23_RS00450	COG0601	transmembrane transport
HJD23_RS00455	COG0747	negative chemotaxis
HJD23_RS00490	COG1131	(ABC) transporter
HJD23_RS00515	COG0745	RESPONSE REGULATOR receiver
HJD23_RS00520	COG5002	protein histidine kinase activity
HJD23_RS00545	COG2272	Belongs to the type-B carboxylesterase lipase family
HJD23_RS00560	COG0028	Belongs to the TPP enzyme family
HJD23_RS00585	COG3842	ATPase activity
HJD23_RS00605	COG2814	Major facilitator Superfamily
HJD23_RS00620	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HJD23_RS00625	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HJD23_RS00650	COG0765	amino acid transport
HJD23_RS00660	COG1802	Transcriptional regulator
HJD23_RS00670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HJD23_RS00675	COG4733	cellulase activity
HJD23_RS00680	COG4677	pectinesterase activity
HJD23_RS00685	COG3866	Pectate lyase
HJD23_RS00700	COG3866	Pectate lyase
HJD23_RS00725	COG0395	ABC-type sugar transport system, permease component
HJD23_RS00730	COG1175	transmembrane transport
HJD23_RS00740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HJD23_RS00745	COG1802	Transcriptional regulator
HJD23_RS00790	COG0673	inositol 2-dehydrogenase activity
HJD23_RS00805	COG3842	ATPase activity
HJD23_RS00815	COG1609	Transcriptional regulator
HJD23_RS00820	COG1609	Transcriptional regulator
HJD23_RS00825	COG2272	Belongs to the type-B carboxylesterase lipase family
HJD23_RS00845	COG3940	Belongs to the glycosyl hydrolase 43 family
HJD23_RS00865	COG0745	RESPONSE REGULATOR receiver
HJD23_RS00890	COG3851	Histidine kinase
HJD23_RS00925	COG3345	alpha-galactosidase
HJD23_RS00940	COG1309	transcriptional regulator
HJD23_RS00955	COG0477	Major facilitator Superfamily
HJD23_RS01005	COG2801	Transposase and inactivated derivatives
HJD23_RS01015	COG3409	Peptidoglycan-binding domain 1 protein
HJD23_RS01055	COG2132	Multicopper oxidase
HJD23_RS01090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HJD23_RS01110	COG0596	Alpha beta hydrolase
HJD23_RS01120	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS01135	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HJD23_RS01160	COG1834	amidinotransferase
HJD23_RS01185	COG0477	Major facilitator Superfamily
HJD23_RS01205	COG0583	DNA-binding transcription factor activity
HJD23_RS01215	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS01245	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HJD23_RS01265	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HJD23_RS01265	COG1024	Enoyl-CoA hydratase
HJD23_RS01275	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HJD23_RS01290	COG0409	Hydrogenase expression formation protein
HJD23_RS01335	COG1609	Transcriptional regulator
HJD23_RS01355	COG0697	spore germination
HJD23_RS01365	COG2801	Transposase and inactivated derivatives
HJD23_RS01365	COG3415	Transposase
HJD23_RS01370	COG0673	inositol 2-dehydrogenase activity
HJD23_RS01375	COG1653	transport
HJD23_RS01380	COG1175	transmembrane transport
HJD23_RS01385	COG0395	ABC-type sugar transport system, permease component
HJD23_RS01425	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HJD23_RS01430	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HJD23_RS01440	COG1295	ribonuclease BN
HJD23_RS01455	COG0473	3-isopropylmalate dehydrogenase activity
HJD23_RS01455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HJD23_RS01470	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HJD23_RS01510	COG4565	transcriptional regulatory protein
HJD23_RS01575	COG0477	Major facilitator Superfamily
HJD23_RS01600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HJD23_RS01605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HJD23_RS01625	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HJD23_RS01640	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HJD23_RS01655	COG1595	DNA-templated transcription, initiation
HJD23_RS01660	COG1764	response to oxidative stress
HJD23_RS01695	COG1595	DNA-templated transcription, initiation
HJD23_RS01700	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HJD23_RS01700	COG1672	PFAM Archaeal ATPase
HJD23_RS01720	COG1595	DNA-templated transcription, initiation
HJD23_RS01740	COG4221	oxidoreductase activity
HJD23_RS01745	COG1309	transcriptional regulator
HJD23_RS01760	COG1595	DNA-templated transcription, initiation
HJD23_RS01785	COG1902	pentaerythritol trinitrate reductase activity
HJD23_RS01790	COG3483	tryptophan 2,3-dioxygenase activity
HJD23_RS01805	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HJD23_RS01825	COG1595	DNA-templated transcription, initiation
HJD23_RS01835	COG1053	succinate dehydrogenase
HJD23_RS01880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HJD23_RS01880	COG4221	oxidoreductase activity
HJD23_RS01880	COG3321	synthase
HJD23_RS01880	COG0604	alcohol dehydrogenase
HJD23_RS01925	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS01955	COG1132	(ABC) transporter
HJD23_RS01985	COG2261	transglycosylase associated protein
HJD23_RS02020	COG3340	Belongs to the peptidase S51 family
HJD23_RS02025	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HJD23_RS02045	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HJD23_RS02100	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HJD23_RS02120	COG1940	carbohydrate kinase activity
HJD23_RS02120	COG1846	Transcriptional regulator
HJD23_RS02155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HJD23_RS02155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HJD23_RS02160	COG0730	response to heat
HJD23_RS02165	COG1937	Protein conserved in bacteria
HJD23_RS02175	COG1132	(ABC) transporter
HJD23_RS02185	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HJD23_RS02210	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HJD23_RS02230	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HJD23_RS02240	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HJD23_RS02245	COG0517	IMP dehydrogenase activity
HJD23_RS02285	COG0248	Ppx GppA phosphatase
HJD23_RS02295	COG0655	NAD(P)H dehydrogenase (quinone) activity
HJD23_RS02305	COG2890	protein-(glutamine-N5) methyltransferase activity
HJD23_RS02355	COG3250	beta-galactosidase activity
HJD23_RS02415	COG0435	Glutathione S-transferase
HJD23_RS02470	COG1012	belongs to the aldehyde dehydrogenase family
HJD23_RS02515	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS02520	COG1796	DNA polymerase
HJD23_RS02520	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HJD23_RS02525	COG0546	phosphoglycolate phosphatase activity
HJD23_RS02560	COG2706	6-phosphogluconolactonase activity
HJD23_RS02570	COG1357	PFAM Pentapeptide repeats (8 copies)
HJD23_RS02585	COG1609	Transcriptional regulator
HJD23_RS02610	COG1172	Belongs to the binding-protein-dependent transport system permease family
HJD23_RS02615	COG1129	ABC transporter
HJD23_RS02625	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS02625	COG3347	Dehydrogenase
HJD23_RS02630	COG1070	Carbohydrate kinase
HJD23_RS02635	COG0247	lactate metabolic process
HJD23_RS02640	COG1139	Iron-sulfur cluster binding protein
HJD23_RS02645	COG1556	Lactate utilization protein
HJD23_RS02650	COG0517	IMP dehydrogenase activity
HJD23_RS02650	COG1125	glycine betaine transport
HJD23_RS02665	COG1174	glycine betaine transport
HJD23_RS02675	COG0542	response to heat
HJD23_RS02690	COG3321	synthase
HJD23_RS02690	COG0604	alcohol dehydrogenase
HJD23_RS02710	COG2207	Transcriptional regulator
HJD23_RS02720	COG1881	PFAM PEBP family protein
HJD23_RS02760	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HJD23_RS02765	COG1278	Cold shock
HJD23_RS02770	COG0640	Transcriptional regulator
HJD23_RS02800	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS02805	COG0028	Belongs to the TPP enzyme family
HJD23_RS02865	COG0516	GMP reductase activity
HJD23_RS02865	COG0517	IMP dehydrogenase activity
HJD23_RS02885	COG0242	peptide deformylase activity
HJD23_RS02890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HJD23_RS02895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HJD23_RS02905	COG1609	Transcriptional regulator
HJD23_RS02920	COG1609	Transcriptional regulator
HJD23_RS02930	COG1175	transmembrane transport
HJD23_RS02935	COG0395	ABC-type sugar transport system, permease component
HJD23_RS02945	COG1501	Belongs to the glycosyl hydrolase 31 family
HJD23_RS02970	COG0589	response to stress
HJD23_RS02995	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HJD23_RS03005	COG1063	alcohol dehydrogenase
HJD23_RS03010	COG1366	Belongs to the anti-sigma-factor antagonist family
HJD23_RS03045	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HJD23_RS03050	COG0121	glutamine amidotransferase
HJD23_RS03055	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HJD23_RS03060	COG2182	Extracellular solute-binding protein
HJD23_RS03065	COG3360	Dodecin
HJD23_RS03075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HJD23_RS03080	COG2801	Transposase and inactivated derivatives
HJD23_RS03080	COG3415	Transposase
HJD23_RS03095	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HJD23_RS03100	COG1053	succinate dehydrogenase
HJD23_RS03110	COG0583	DNA-binding transcription factor activity
HJD23_RS03150	COG0726	polysaccharide deacetylase
HJD23_RS03155	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HJD23_RS03155	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HJD23_RS03165	COG0531	amino acid
HJD23_RS03205	COG2770	Histidine kinase
HJD23_RS03205	COG2208	phosphoserine phosphatase activity
HJD23_RS03210	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HJD23_RS03230	COG3618	amidohydrolase
HJD23_RS03245	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS03250	COG4948	Mandelate Racemase Muconate Lactonizing
HJD23_RS03255	COG2186	Transcriptional regulator
HJD23_RS03265	COG0154	amidase activity
HJD23_RS03300	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HJD23_RS03305	COG0297	glycogen (starch) synthase activity
HJD23_RS03325	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HJD23_RS03340	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HJD23_RS03420	COG3973	AAA domain
HJD23_RS03435	COG2124	cytochrome p450
HJD23_RS03470	COG1132	(ABC) transporter
HJD23_RS03480	COG1024	Enoyl-CoA hydratase
HJD23_RS03505	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HJD23_RS03520	COG0668	transmembrane transport
HJD23_RS03525	COG2838	Isocitrate dehydrogenase
HJD23_RS03535	COG2124	cytochrome p450
HJD23_RS03560	COG2197	response regulator
HJD23_RS03595	COG0745	RESPONSE REGULATOR receiver
HJD23_RS03600	COG2205	protein histidine kinase activity
HJD23_RS03610	COG0673	inositol 2-dehydrogenase activity
HJD23_RS03615	COG1609	Transcriptional regulator
HJD23_RS03625	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS03630	COG0673	inositol 2-dehydrogenase activity
HJD23_RS03635	COG0076	glutamate decarboxylase activity
HJD23_RS03670	COG2188	Transcriptional regulator
HJD23_RS03680	COG0494	nUDIX hydrolase
HJD23_RS03725	COG0183	Belongs to the thiolase family
HJD23_RS03730	COG2267	carboxylic ester hydrolase activity
HJD23_RS03760	COG1473	amidohydrolase
HJD23_RS03770	COG0515	serine threonine protein kinase
HJD23_RS03770	COG2815	serine threonine protein kinase
HJD23_RS03780	COG2268	Band 7 protein
HJD23_RS03785	COG1585	Membrane protein implicated in regulation of membrane protease activity
HJD23_RS03790	COG0561	phosphatase activity
HJD23_RS03935	COG0438	transferase activity, transferring glycosyl groups
HJD23_RS04255	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HJD23_RS04280	COG3959	Transketolase, thiamine diphosphate binding domain
HJD23_RS04285	COG3958	Transketolase
HJD23_RS04305	COG0583	DNA-binding transcription factor activity
HJD23_RS04310	COG0156	8-amino-7-oxononanoate synthase activity
HJD23_RS04315	COG1063	alcohol dehydrogenase
HJD23_RS04350	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HJD23_RS04360	COG2755	lipolytic protein G-D-S-L family
HJD23_RS04365	COG0739	heme binding
HJD23_RS04400	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HJD23_RS04415	COG1657	PFAM Prenyltransferase squalene oxidase
HJD23_RS04425	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HJD23_RS04435	COG1562	ergosterol biosynthetic process
HJD23_RS04440	COG1134	teichoic acid transport
HJD23_RS04485	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HJD23_RS04500	COG1024	Enoyl-CoA hydratase
HJD23_RS04510	COG4977	sequence-specific DNA binding
HJD23_RS04520	COG2183	response to ionizing radiation
HJD23_RS04530	COG0488	(ABC) transporter
HJD23_RS04545	COG2936	dipeptidyl-peptidase activity
HJD23_RS04555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HJD23_RS04565	COG1113	amino acid transport
HJD23_RS04575	COG1250	3-hydroxyacyl-CoA dehydrogenase
HJD23_RS04575	COG1024	Enoyl-CoA hydratase
HJD23_RS04580	COG0183	Belongs to the thiolase family
HJD23_RS04585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HJD23_RS04595	COG3268	Saccharopine dehydrogenase
HJD23_RS04605	COG1515	deoxyribonuclease V activity
HJD23_RS04620	COG0488	(ABC) transporter
HJD23_RS04625	COG1834	amidinotransferase
HJD23_RS04695	COG1793	dna ligase
HJD23_RS04705	COG1470	cell adhesion involved in biofilm formation
HJD23_RS04730	COG3485	protocatechuate 3,4-dioxygenase
HJD23_RS04735	COG3485	protocatechuate 3,4-dioxygenase
HJD23_RS04740	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HJD23_RS04745	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HJD23_RS04765	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HJD23_RS04790	COG3511	phospholipase C
HJD23_RS04800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HJD23_RS04805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HJD23_RS04810	COG1116	anion transmembrane transporter activity
HJD23_RS04865	COG1486	melibiose metabolic process
HJD23_RS04875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HJD23_RS04885	COG1175	transmembrane transport
HJD23_RS04895	COG3250	beta-galactosidase activity
HJD23_RS04900	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HJD23_RS04930	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS04940	COG0477	Major facilitator Superfamily
HJD23_RS04970	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HJD23_RS04985	COG0166	Belongs to the GPI family
HJD23_RS04990	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HJD23_RS04995	COG0588	phosphoglycerate mutase activity
HJD23_RS05010	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HJD23_RS05020	COG0477	Major facilitator Superfamily
HJD23_RS05035	COG0477	Major facilitator Superfamily
HJD23_RS05045	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HJD23_RS05065	COG3467	pyridoxamine 5'-phosphate
HJD23_RS05075	COG0477	Major facilitator Superfamily
HJD23_RS05105	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HJD23_RS05120	COG0297	glycogen (starch) synthase activity
HJD23_RS05160	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HJD23_RS05170	COG0584	glycerophosphoryl diester phosphodiesterase
HJD23_RS05190	COG1012	belongs to the aldehyde dehydrogenase family
HJD23_RS05200	COG0045	succinate-CoA ligase (ADP-forming) activity
HJD23_RS05210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HJD23_RS05220	COG2223	nitrite transmembrane transporter activity
HJD23_RS05240	COG0084	hydrolase, TatD family'
HJD23_RS05275	COG0673	inositol 2-dehydrogenase activity
HJD23_RS05285	COG1172	Belongs to the binding-protein-dependent transport system permease family
HJD23_RS05290	COG1129	ABC transporter
HJD23_RS05295	COG1940	carbohydrate kinase activity
HJD23_RS05310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HJD23_RS05320	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HJD23_RS05325	COG3383	formate dehydrogenase (NAD+) activity
HJD23_RS05330	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HJD23_RS05340	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HJD23_RS05370	COG0656	L-ascorbic acid biosynthetic process
HJD23_RS05375	COG4249	Peptidase C14 caspase catalytic subunit p20
HJD23_RS05375	COG2319	Wd-40 repeat
HJD23_RS05395	COG5297	Belongs to the glycosyl hydrolase family 6
HJD23_RS05405	COG4733	cellulase activity
HJD23_RS05405	COG5297	Belongs to the glycosyl hydrolase family 6
HJD23_RS05415	COG3401	FG-GAP repeat protein
HJD23_RS05430	COG2154	pterin-4-alpha-carbinolamine dehydratase
HJD23_RS05450	COG0443	Heat shock 70 kDa protein
HJD23_RS05510	COG0028	Belongs to the TPP enzyme family
HJD23_RS05525	COG0693	protein deglycase activity
HJD23_RS05545	COG0406	alpha-ribazole phosphatase activity
HJD23_RS05555	COG2226	methyltransferase
HJD23_RS05615	COG1793	dna ligase
HJD23_RS05615	COG3285	dna ligase
HJD23_RS05630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HJD23_RS05635	COG4221	oxidoreductase activity
HJD23_RS05655	COG1619	proteins homologs of microcin C7 resistance protein MccF
HJD23_RS05660	COG4946	Tricorn protease homolog
HJD23_RS05660	COG1506	peptidase
HJD23_RS05660	COG0823	Involved in the tonB-independent uptake of proteins
HJD23_RS05665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HJD23_RS05670	COG2362	D-Aminopeptidase
HJD23_RS05675	COG2226	methyltransferase
HJD23_RS05715	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HJD23_RS05750	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HJD23_RS05765	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HJD23_RS05785	COG0596	Alpha beta hydrolase
HJD23_RS05795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HJD23_RS05795	COG0456	acetyltransferase
HJD23_RS05805	COG1250	3-hydroxyacyl-CoA dehydrogenase
HJD23_RS05820	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HJD23_RS05820	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HJD23_RS05825	COG2301	Belongs to the HpcH HpaI aldolase family
HJD23_RS05835	COG1960	acyl-CoA dehydrogenase activity
HJD23_RS05840	COG0688	phosphatidylethanolamine metabolic process
HJD23_RS05850	COG1929	Belongs to the glycerate kinase type-1 family
HJD23_RS05870	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HJD23_RS05875	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HJD23_RS05890	COG0640	Transcriptional regulator
HJD23_RS05910	COG0517	IMP dehydrogenase activity
HJD23_RS05925	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HJD23_RS05935	COG0483	inositol monophosphate 1-phosphatase activity
HJD23_RS05950	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HJD23_RS05955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HJD23_RS05960	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HJD23_RS05975	COG1953	Uracil, thiamine, allantoin
HJD23_RS05985	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HJD23_RS06025	COG0542	response to heat
HJD23_RS06030	COG0405	Gamma-glutamyltransferase
HJD23_RS06040	COG2936	dipeptidyl-peptidase activity
HJD23_RS06060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HJD23_RS06065	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HJD23_RS06095	COG2801	Transposase and inactivated derivatives
HJD23_RS06100	COG2801	Transposase and inactivated derivatives
HJD23_RS06180	COG4326	sporulation control protein
HJD23_RS06215	COG1316	TRANSCRIPTIONal
HJD23_RS06235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HJD23_RS06260	COG2801	Transposase and inactivated derivatives
HJD23_RS06280	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HJD23_RS06305	COG1302	Protein conserved in bacteria
HJD23_RS06425	COG1294	oxidase, subunit
HJD23_RS06430	COG1271	oxidase subunit
HJD23_RS06550	COG2706	6-phosphogluconolactonase activity
HJD23_RS06565	COG0395	ABC-type sugar transport system, permease component
HJD23_RS06570	COG1175	transmembrane transport
HJD23_RS06580	COG1609	Transcriptional regulator
HJD23_RS06590	COG4948	Mandelate Racemase Muconate Lactonizing
HJD23_RS06645	COG2801	Transposase and inactivated derivatives
HJD23_RS06660	COG1446	asparaginase
HJD23_RS06680	COG0395	ABC-type sugar transport system, permease component
HJD23_RS06685	COG1175	transmembrane transport
HJD23_RS06695	COG1609	Transcriptional regulator
HJD23_RS06700	COG1621	beta-fructofuranosidase activity
HJD23_RS06730	COG1609	Transcriptional regulator
HJD23_RS06760	COG0523	cobalamin synthesis protein
HJD23_RS06775	COG0640	Transcriptional regulator
HJD23_RS06810	COG1169	isochorismate synthase
HJD23_RS06815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HJD23_RS06815	COG2226	methyltransferase
HJD23_RS06815	COG3433	isochorismatase activity
HJD23_RS06845	COG0667	Aldo Keto reductase
HJD23_RS06855	COG2124	cytochrome p450
HJD23_RS06860	COG0592	DNA-directed DNA polymerase activity
HJD23_RS06875	COG0321	lipoyl(octanoyl) transferase activity
HJD23_RS06885	COG2267	carboxylic ester hydrolase activity
HJD23_RS06895	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS06935	COG2264	protein methyltransferase activity
HJD23_RS06975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HJD23_RS07020	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS07030	COG2814	Major facilitator Superfamily
HJD23_RS07040	COG0367	asparagine synthase
HJD23_RS07055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HJD23_RS07065	COG1940	carbohydrate kinase activity
HJD23_RS07085	COG2188	Transcriptional regulator
HJD23_RS07090	COG0673	inositol 2-dehydrogenase activity
HJD23_RS07100	COG4941	Belongs to the sigma-70 factor family
HJD23_RS07115	COG2197	response regulator
HJD23_RS07120	COG4585	Histidine kinase
HJD23_RS07130	COG1609	Transcriptional regulator
HJD23_RS07150	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS07155	COG4266	Belongs to the allantoicase family
HJD23_RS07160	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HJD23_RS07165	COG1414	Transcriptional regulator
HJD23_RS07195	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HJD23_RS07200	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HJD23_RS07205	COG1733	regulation of RNA biosynthetic process
HJD23_RS07235	COG1846	Transcriptional regulator
HJD23_RS07245	COG2080	2 iron, 2 sulfur cluster binding
HJD23_RS07250	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HJD23_RS07255	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HJD23_RS07260	COG1309	transcriptional regulator
HJD23_RS07290	COG1733	regulation of RNA biosynthetic process
HJD23_RS07295	COG0436	Aminotransferase
HJD23_RS07300	COG0406	alpha-ribazole phosphatase activity
HJD23_RS07315	COG1733	regulation of RNA biosynthetic process
HJD23_RS07325	COG2233	PERMEase
HJD23_RS07340	COG2351	hydroxyisourate hydrolase activity
HJD23_RS07400	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HJD23_RS07430	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HJD23_RS07450	COG3622	Belongs to the hyi family
HJD23_RS07455	COG2084	Dehydrogenase
HJD23_RS07460	COG0753	catalase activity
HJD23_RS07475	COG3960	tartronate-semialdehyde synthase activity
HJD23_RS07485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HJD23_RS07520	COG1621	beta-fructofuranosidase activity
HJD23_RS07540	COG1175	transmembrane transport
HJD23_RS07560	COG0589	response to stress
HJD23_RS07585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HJD23_RS07605	COG0789	Transcriptional regulator
HJD23_RS07640	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HJD23_RS07665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HJD23_RS07680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HJD23_RS07690	COG2226	methyltransferase
HJD23_RS07700	COG1595	DNA-templated transcription, initiation
HJD23_RS07705	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HJD23_RS07735	COG1116	anion transmembrane transporter activity
HJD23_RS07760	COG3795	YCII-related domain
HJD23_RS07770	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HJD23_RS07775	COG1993	acr, cog1993
HJD23_RS07780	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HJD23_RS07790	COG1609	Transcriptional regulator
HJD23_RS07805	COG0673	inositol 2-dehydrogenase activity
HJD23_RS07810	COG1082	Xylose isomerase domain protein TIM barrel
HJD23_RS07860	COG2252	PERMEase
HJD23_RS07865	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HJD23_RS07880	COG3835	regulator
HJD23_RS07890	COG1802	Transcriptional regulator
HJD23_RS07930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HJD23_RS07940	COG1162	GTPase activity
HJD23_RS07945	COG4214	carbohydrate transport
HJD23_RS07950	COG1129	ABC transporter
HJD23_RS07955	COG4213	ABC transporter substrate-binding protein
HJD23_RS07965	COG4213	ABC transporter substrate-binding protein
HJD23_RS07970	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HJD23_RS07980	COG0277	FAD linked oxidase domain protein
HJD23_RS07995	COG1175	transmembrane transport
HJD23_RS08000	COG0395	ABC-type sugar transport system, permease component
HJD23_RS08010	COG1131	(ABC) transporter
HJD23_RS08050	COG3940	Belongs to the glycosyl hydrolase 43 family
HJD23_RS08055	COG3940	Belongs to the glycosyl hydrolase 43 family
HJD23_RS08080	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HJD23_RS08125	COG2040	homocysteine
HJD23_RS08130	COG1609	Transcriptional regulator
HJD23_RS08165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HJD23_RS08170	COG1609	Transcriptional regulator
HJD23_RS08180	COG1175	transmembrane transport
HJD23_RS08235	COG0745	RESPONSE REGULATOR receiver
HJD23_RS08240	COG2205	protein histidine kinase activity
HJD23_RS08245	COG2226	methyltransferase
HJD23_RS08275	COG1960	acyl-CoA dehydrogenase activity
HJD23_RS08305	COG0175	sulfate reduction
HJD23_RS08310	COG0529	Catalyzes the synthesis of activated sulfate
HJD23_RS08335	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HJD23_RS08340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HJD23_RS08350	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HJD23_RS08360	COG2409	Drug exporters of the RND superfamily
HJD23_RS08375	COG0583	DNA-binding transcription factor activity
HJD23_RS08465	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HJD23_RS08485	COG2801	Transposase and inactivated derivatives
HJD23_RS08490	COG2801	Transposase and inactivated derivatives
HJD23_RS08510	COG1309	transcriptional regulator
HJD23_RS08525	COG1404	Belongs to the peptidase S8 family
HJD23_RS08535	COG5002	protein histidine kinase activity
HJD23_RS08540	COG2018	Roadblock/LC7 domain
HJD23_RS08555	COG1174	glycine betaine transport
HJD23_RS08560	COG1174	glycine betaine transport
HJD23_RS08585	COG0745	RESPONSE REGULATOR receiver
HJD23_RS08590	COG2205	protein histidine kinase activity
HJD23_RS08595	COG5002	protein histidine kinase activity
HJD23_RS08600	COG0745	RESPONSE REGULATOR receiver
HJD23_RS08625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HJD23_RS08630	COG3938	Belongs to the proline racemase family
HJD23_RS08685	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HJD23_RS08690	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HJD23_RS08750	COG3220	belongs to the UPF0276 family
HJD23_RS08780	COG0446	pyridine nucleotide-disulphide oxidoreductase
HJD23_RS08795	COG2239	Acts as a magnesium transporter
HJD23_RS08800	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HJD23_RS08815	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HJD23_RS08825	COG1175	transmembrane transport
HJD23_RS08835	COG3250	beta-galactosidase activity
HJD23_RS08840	COG1609	Transcriptional regulator
HJD23_RS08845	COG0183	Belongs to the thiolase family
HJD23_RS08850	COG1250	3-hydroxyacyl-CoA dehydrogenase
HJD23_RS08850	COG1024	Enoyl-CoA hydratase
HJD23_RS08870	COG0438	transferase activity, transferring glycosyl groups
HJD23_RS08875	COG0438	transferase activity, transferring glycosyl groups
HJD23_RS08880	COG0438	transferase activity, transferring glycosyl groups
HJD23_RS08885	COG0438	transferase activity, transferring glycosyl groups
HJD23_RS08890	COG1316	TRANSCRIPTIONal
HJD23_RS08915	COG0531	amino acid
HJD23_RS08920	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HJD23_RS08925	COG4214	carbohydrate transport
HJD23_RS08935	COG4213	ABC transporter substrate-binding protein
HJD23_RS08940	COG1940	carbohydrate kinase activity
HJD23_RS08945	COG0395	ABC-type sugar transport system, permease component
HJD23_RS08950	COG1175	transmembrane transport
HJD23_RS08955	COG1653	transport
HJD23_RS08965	COG1595	DNA-templated transcription, initiation
HJD23_RS08980	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HJD23_RS08990	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HJD23_RS08995	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HJD23_RS09030	COG3483	tryptophan 2,3-dioxygenase activity
HJD23_RS09035	COG0822	iron-sulfur transferase activity
HJD23_RS09045	COG0745	RESPONSE REGULATOR receiver
HJD23_RS09055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HJD23_RS09065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HJD23_RS09115	COG0789	Transcriptional regulator
HJD23_RS09130	COG1132	(ABC) transporter
HJD23_RS09135	COG1132	(ABC) transporter
HJD23_RS09160	COG1120	ATPase activity
HJD23_RS09165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HJD23_RS09170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HJD23_RS09240	COG1024	Enoyl-CoA hydratase
HJD23_RS09250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HJD23_RS09255	COG2235	arginine
HJD23_RS09260	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HJD23_RS09305	COG1799	cell septum assembly
HJD23_RS09420	COG0673	inositol 2-dehydrogenase activity
HJD23_RS09430	COG0395	ABC-type sugar transport system, permease component
HJD23_RS09435	COG1175	transmembrane transport
HJD23_RS09440	COG1609	Transcriptional regulator
HJD23_RS09445	COG0366	Alpha amylase catalytic
HJD23_RS09460	COG1653	transport
HJD23_RS09465	COG1609	Transcriptional regulator
HJD23_RS09495	COG1609	Transcriptional regulator
HJD23_RS09500	COG1609	Transcriptional regulator
HJD23_RS09505	COG3693	PFAM glycoside hydrolase, family 10
HJD23_RS09520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HJD23_RS09525	COG0531	amino acid
HJD23_RS09530	COG0569	domain protein
HJD23_RS09565	COG0756	dUTP diphosphatase activity
HJD23_RS09590	COG2205	protein histidine kinase activity
HJD23_RS09595	COG0745	RESPONSE REGULATOR receiver
HJD23_RS09640	COG1435	thymidine kinase activity
HJD23_RS09660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HJD23_RS09665	COG1802	Transcriptional regulator
HJD23_RS09680	COG0612	Peptidase, M16
HJD23_RS09685	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HJD23_RS09695	COG0372	Belongs to the citrate synthase family
HJD23_RS09710	COG3290	protein histidine kinase activity
HJD23_RS09715	COG4565	transcriptional regulatory protein
HJD23_RS09720	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HJD23_RS09730	COG0187	DNA topoisomerase II activity
HJD23_RS09755	COG1802	Transcriptional regulator
HJD23_RS09785	COG1132	(ABC) transporter
HJD23_RS09790	COG2226	methyltransferase
HJD23_RS09820	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HJD23_RS09825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HJD23_RS09835	COG0515	serine threonine protein kinase
HJD23_RS09840	COG0318	PFAM AMP-dependent synthetase and ligase
HJD23_RS09845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HJD23_RS09855	COG0318	PFAM AMP-dependent synthetase and ligase
HJD23_RS09860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HJD23_RS09860	COG3321	synthase
HJD23_RS09880	COG2030	dehydratase
HJD23_RS09890	COG0514	ATP-dependent DNA helicase (RecQ)
HJD23_RS09905	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HJD23_RS09940	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HJD23_RS09945	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HJD23_RS09950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HJD23_RS09985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HJD23_RS09995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HJD23_RS10000	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HJD23_RS10010	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HJD23_RS10030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HJD23_RS10045	COG4335	DNA alkylation repair
HJD23_RS10085	COG2205	protein histidine kinase activity
HJD23_RS10090	COG0745	RESPONSE REGULATOR receiver
HJD23_RS10095	COG1126	abc transporter atp-binding protein
HJD23_RS10100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HJD23_RS10105	COG0765	amino acid transport
HJD23_RS10110	COG0765	amino acid transport
HJD23_RS10115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HJD23_RS10125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HJD23_RS10135	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HJD23_RS10145	COG0628	permease
HJD23_RS10170	COG1917	Cupin 2, conserved barrel domain protein
HJD23_RS10170	COG2207	Transcriptional regulator
HJD23_RS10175	COG1201	RNA secondary structure unwinding
HJD23_RS10180	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HJD23_RS10185	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS10190	COG0783	Belongs to the Dps family
HJD23_RS10195	COG1396	sequence-specific DNA binding
HJD23_RS10200	COG1546	Belongs to the CinA family
HJD23_RS10200	COG1058	Belongs to the CinA family
HJD23_RS10210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HJD23_RS10220	COG1674	ftsk spoiiie
HJD23_RS10230	COG3437	response regulator, receiver
HJD23_RS10230	COG2205	protein histidine kinase activity
HJD23_RS10230	COG3850	Histidine kinase
HJD23_RS10230	COG4999	Histidine kinase
HJD23_RS10235	COG2208	phosphoserine phosphatase activity
HJD23_RS10235	COG2770	Histidine kinase
HJD23_RS10265	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HJD23_RS10270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HJD23_RS10275	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HJD23_RS10295	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HJD23_RS10300	COG0612	Peptidase, M16
HJD23_RS10305	COG1185	polyribonucleotide nucleotidyltransferase activity
HJD23_RS10310	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HJD23_RS10330	COG1674	ftsk spoiiie
HJD23_RS10350	COG1404	Belongs to the peptidase S8 family
HJD23_RS10400	COG1404	Belongs to the peptidase S8 family
HJD23_RS10420	COG0455	bacterial-type flagellum organization
HJD23_RS10435	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HJD23_RS10440	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HJD23_RS10450	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HJD23_RS10465	COG0779	Required for maturation of 30S ribosomal subunits
HJD23_RS10490	COG0442	prolyl-tRNA aminoacylation
HJD23_RS10505	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HJD23_RS10510	COG0750	zinc metalloprotease
HJD23_RS10515	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HJD23_RS10535	COG3250	beta-galactosidase activity
HJD23_RS10545	COG1175	transmembrane transport
HJD23_RS10590	COG0395	ABC-type sugar transport system, permease component
HJD23_RS10595	COG4209	transmembrane transport
HJD23_RS10610	COG1012	belongs to the aldehyde dehydrogenase family
HJD23_RS10615	COG2508	Transcriptional regulator
HJD23_RS10645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HJD23_RS10650	COG1177	transmembrane transport
HJD23_RS10655	COG1176	ABC-type spermidine putrescine transport system, permease component I
HJD23_RS10660	COG3842	ATPase activity
HJD23_RS10685	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HJD23_RS10690	COG0584	glycerophosphoryl diester phosphodiesterase
HJD23_RS10700	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HJD23_RS10705	COG0590	tRNA wobble adenosine to inosine editing
HJD23_RS10710	COG1012	belongs to the aldehyde dehydrogenase family
HJD23_RS10720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HJD23_RS10725	COG1136	(ABC) transporter
HJD23_RS10750	COG3842	ATPase activity
HJD23_RS10755	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HJD23_RS10765	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HJD23_RS10770	COG0575	Belongs to the CDS family
HJD23_RS10775	COG0233	cytoplasmic translational termination
HJD23_RS10780	COG0528	UMP kinase activity
HJD23_RS10785	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HJD23_RS10790	COG0052	Belongs to the universal ribosomal protein uS2 family
HJD23_RS10795	COG4942	peptidase
HJD23_RS10805	COG1191	sigma factor activity
HJD23_RS10820	COG0792	nuclease activity
HJD23_RS10830	COG1051	belongs to the nudix hydrolase family
HJD23_RS10835	COG0681	Belongs to the peptidase S26 family
HJD23_RS10840	COG0681	Belongs to the peptidase S26 family
HJD23_RS10850	COG0681	Belongs to the peptidase S26 family
HJD23_RS10855	COG0335	large ribosomal subunit rRNA binding
HJD23_RS10860	COG0336	Belongs to the RNA methyltransferase TrmD family
HJD23_RS10865	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HJD23_RS10870	COG1837	Belongs to the UPF0109 family
HJD23_RS10875	COG0228	four-way junction DNA binding
HJD23_RS10890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HJD23_RS10905	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HJD23_RS10940	COG0477	Major facilitator Superfamily
HJD23_RS10945	COG1196	nuclear chromosome segregation
HJD23_RS10955	COG1254	Belongs to the acylphosphatase family
HJD23_RS10960	COG2340	Cysteine-rich secretory protein family
HJD23_RS10965	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HJD23_RS10970	COG0571	ribonuclease III activity
HJD23_RS10975	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HJD23_RS10990	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HJD23_RS10995	COG0742	ribosomal rna small subunit methyltransferase
HJD23_RS11005	COG0326	Molecular chaperone. Has ATPase activity
HJD23_RS11015	COG1461	Dihydroxyacetone kinase
HJD23_RS11020	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HJD23_RS11025	COG0351	phosphomethylpyrimidine kinase
HJD23_RS11045	COG1181	Belongs to the D-alanine--D-alanine ligase family
HJD23_RS11050	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HJD23_RS11060	COG1920	GTP binding
HJD23_RS11070	COG0776	regulation of translation
HJD23_RS11080	COG0066	3-isopropylmalate dehydratase activity
HJD23_RS11085	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HJD23_RS11090	COG1414	Transcriptional regulator
HJD23_RS11140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HJD23_RS11145	COG0179	Fumarylacetoacetate (FAA) hydrolase
HJD23_RS11160	COG2018	Roadblock/LC7 domain
HJD23_RS11180	COG2018	Roadblock/LC7 domain
HJD23_RS11200	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HJD23_RS11205	COG0300	oxidoreductase activity
HJD23_RS11210	COG1032	radical SAM domain protein
HJD23_RS11215	COG0697	spore germination
HJD23_RS11220	COG0438	transferase activity, transferring glycosyl groups
HJD23_RS11315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HJD23_RS11325	COG2957	Belongs to the agmatine deiminase family
HJD23_RS11330	COG0804	urea catabolic process
HJD23_RS11335	COG0832	Belongs to the urease beta subunit family
HJD23_RS11335	COG0831	urea catabolic process
HJD23_RS11345	COG3284	Transcriptional regulator
HJD23_RS11350	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HJD23_RS11355	COG0473	3-isopropylmalate dehydrogenase activity
HJD23_RS11365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HJD23_RS11370	COG2267	carboxylic ester hydrolase activity
HJD23_RS11375	COG1012	belongs to the aldehyde dehydrogenase family
HJD23_RS11380	COG0506	proline dehydrogenase activity
HJD23_RS11385	COG2508	Transcriptional regulator
HJD23_RS11390	COG4166	transmembrane transport
HJD23_RS11395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HJD23_RS11405	COG4608	Belongs to the ABC transporter superfamily
HJD23_RS11415	COG0477	Major facilitator Superfamily
HJD23_RS11420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HJD23_RS11425	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HJD23_RS11430	COG0440	acetolactate synthase activity
HJD23_RS11440	COG5001	Diguanylate cyclase
HJD23_RS11450	COG0667	Aldo Keto reductase
HJD23_RS11455	COG2133	pyrroloquinoline quinone binding
HJD23_RS11465	COG2197	response regulator
HJD23_RS11530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HJD23_RS11535	COG2409	Drug exporters of the RND superfamily
HJD23_RS11540	COG2226	methyltransferase
HJD23_RS11545	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HJD23_RS11555	COG0154	amidase activity
HJD23_RS11560	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HJD23_RS11570	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HJD23_RS11580	COG4221	oxidoreductase activity
HJD23_RS11585	COG1611	Belongs to the LOG family
HJD23_RS11595	COG0482	sulfurtransferase activity
HJD23_RS11600	COG3023	N-Acetylmuramoyl-L-alanine amidase
HJD23_RS11620	COG1309	transcriptional regulator
HJD23_RS11630	COG2860	membrane
HJD23_RS11635	COG4608	Belongs to the ABC transporter superfamily
HJD23_RS11640	COG0444	Belongs to the ABC transporter superfamily
HJD23_RS11655	COG4166	transmembrane transport
HJD23_RS11675	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HJD23_RS11680	COG0509	glycine decarboxylation via glycine cleavage system
HJD23_RS11685	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HJD23_RS11690	COG1760	l-serine dehydratase
HJD23_RS11695	COG3757	hydrolase, family 25
HJD23_RS11695	COG3409	Peptidoglycan-binding domain 1 protein
HJD23_RS11740	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HJD23_RS11775	COG3415	Transposase
HJD23_RS11775	COG2801	Transposase and inactivated derivatives
HJD23_RS11790	COG1376	ErfK ybiS ycfS ynhG family protein
HJD23_RS11805	COG1132	(ABC) transporter
HJD23_RS11810	COG1132	(ABC) transporter
HJD23_RS11815	COG1132	(ABC) transporter
HJD23_RS11820	COG1132	(ABC) transporter
HJD23_RS11870	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HJD23_RS11875	COG3281	Trehalose synthase
HJD23_RS11885	COG0366	Alpha amylase catalytic
HJD23_RS11895	COG0058	SHG alpha-glucan phosphorylase activity
HJD23_RS11920	COG3290	protein histidine kinase activity
HJD23_RS11925	COG4565	transcriptional regulatory protein
HJD23_RS11940	COG3903	Transcriptional regulator
HJD23_RS11940	COG3629	intracellular signal transduction
HJD23_RS11960	COG0205	6-phosphofructokinase activity
HJD23_RS11965	COG0280	phosphate acetyltransferase
HJD23_RS11965	COG0857	belongs to the CobB CobQ family
HJD23_RS11970	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HJD23_RS12005	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HJD23_RS12005	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HJD23_RS12085	COG0183	Belongs to the thiolase family
HJD23_RS12105	COG1131	(ABC) transporter
HJD23_RS12140	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HJD23_RS12155	COG1250	3-hydroxyacyl-CoA dehydrogenase
HJD23_RS12170	COG4585	Histidine kinase
HJD23_RS12175	COG2197	response regulator
HJD23_RS12190	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HJD23_RS12195	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HJD23_RS12200	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HJD23_RS12205	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HJD23_RS12210	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HJD23_RS12215	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HJD23_RS12220	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HJD23_RS12240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HJD23_RS12245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HJD23_RS12255	COG2890	protein-(glutamine-N5) methyltransferase activity
HJD23_RS12260	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HJD23_RS12265	COG0254	rRNA binding
HJD23_RS12280	COG0083	homoserine kinase activity
HJD23_RS12285	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HJD23_RS12290	COG0460	homoserine dehydrogenase
HJD23_RS12295	COG0019	diaminopimelate decarboxylase activity
HJD23_RS12300	COG0018	arginyl-trna synthetase
HJD23_RS12350	COG0783	Belongs to the Dps family
HJD23_RS12385	COG1335	isochorismatase
HJD23_RS12390	COG2259	Doxx family
HJD23_RS12395	COG3619	membrane
HJD23_RS12400	COG2814	Major facilitator Superfamily
HJD23_RS12455	COG1132	(ABC) transporter
HJD23_RS12460	COG2267	carboxylic ester hydrolase activity
HJD23_RS12475	COG0640	Transcriptional regulator
HJD23_RS12480	COG2239	Acts as a magnesium transporter
HJD23_RS12490	COG1116	anion transmembrane transporter activity
HJD23_RS12560	COG1309	transcriptional regulator
HJD23_RS12570	COG2226	methyltransferase
HJD23_RS12575	COG2132	Multicopper oxidase
HJD23_RS12595	COG2814	Major facilitator Superfamily
HJD23_RS12660	COG3263	regulation of cellular component size
HJD23_RS12675	COG1253	flavin adenine dinucleotide binding
HJD23_RS12695	COG0028	Belongs to the TPP enzyme family
HJD23_RS12700	COG1320	monovalent cation:proton antiporter activity
HJD23_RS12725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HJD23_RS12725	COG2111	Na H antiporter
HJD23_RS12730	COG3387	PFAM Glycoside hydrolase 15-related
HJD23_RS12735	COG2208	phosphoserine phosphatase activity
HJD23_RS12735	COG2770	Histidine kinase
HJD23_RS12755	COG0659	secondary active sulfate transmembrane transporter activity
HJD23_RS12775	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HJD23_RS12845	COG1120	ATPase activity
HJD23_RS12870	COG0515	serine threonine protein kinase
HJD23_RS12870	COG2815	serine threonine protein kinase
HJD23_RS12880	COG0310	cobalt ion transport
HJD23_RS12885	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
HJD23_RS12895	COG1122	ATPase activity
HJD23_RS12900	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HJD23_RS12905	COG1793	dna ligase
HJD23_RS12905	COG3285	dna ligase
HJD23_RS12930	COG2205	protein histidine kinase activity
HJD23_RS12975	COG0791	NLP P60 protein
HJD23_RS13000	COG5002	protein histidine kinase activity
HJD23_RS13020	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HJD23_RS13045	COG0745	RESPONSE REGULATOR receiver
HJD23_RS13050	COG2205	protein histidine kinase activity
HJD23_RS13055	COG0567	Dehydrogenase, E1 component
HJD23_RS13055	COG0508	dehydrogenase complex catalyzes the overall conversion of
HJD23_RS13080	COG2255	four-way junction helicase activity
HJD23_RS13120	COG0604	alcohol dehydrogenase
HJD23_RS13125	COG0281	malic enzyme
HJD23_RS13130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HJD23_RS13140	COG1126	abc transporter atp-binding protein
HJD23_RS13145	COG4106	trans-aconitate 2-methyltransferase activity
HJD23_RS13175	COG3415	Transposase
HJD23_RS13175	COG2801	Transposase and inactivated derivatives
HJD23_RS13180	COG4941	Belongs to the sigma-70 factor family
HJD23_RS13205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HJD23_RS13215	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HJD23_RS13245	COG1597	lipid kinase activity
HJD23_RS13265	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS13270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HJD23_RS13275	COG0363	glucosamine-6-phosphate deaminase activity
HJD23_RS13285	COG1472	Belongs to the glycosyl hydrolase 3 family
HJD23_RS13290	COG0395	ABC-type sugar transport system, permease component
HJD23_RS13295	COG1175	transmembrane transport
HJD23_RS13300	COG2182	Extracellular solute-binding protein
HJD23_RS13305	COG2188	Transcriptional regulator
HJD23_RS13340	COG2124	cytochrome p450
HJD23_RS13350	COG0242	peptide deformylase activity
HJD23_RS13365	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HJD23_RS13365	COG2199	diguanylate cyclase activity
HJD23_RS13370	COG5662	AntiSigma factor
HJD23_RS13375	COG1595	DNA-templated transcription, initiation
HJD23_RS13385	COG2135	peptidase activity
HJD23_RS13400	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HJD23_RS13405	COG1162	GTPase activity
HJD23_RS13420	COG0483	inositol monophosphate 1-phosphatase activity
HJD23_RS13430	COG0753	catalase activity
HJD23_RS13445	COG2801	Transposase and inactivated derivatives
HJD23_RS13445	COG3415	Transposase
HJD23_RS13460	COG1615	UPF0182 protein
HJD23_RS13470	COG3480	Lon protease (S16) C-terminal proteolytic domain
HJD23_RS13525	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HJD23_RS13560	COG2362	D-Aminopeptidase
HJD23_RS13570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HJD23_RS13575	COG0210	DNA helicase
HJD23_RS13665	COG0513	Belongs to the DEAD box helicase family
HJD23_RS13675	COG1432	Conserved Protein
HJD23_RS13685	COG2095	MarC family integral membrane protein
HJD23_RS13705	COG0598	Magnesium transport protein CorA
HJD23_RS13740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HJD23_RS13755	COG1595	DNA-templated transcription, initiation
HJD23_RS13770	COG1024	Enoyl-CoA hydratase
HJD23_RS13775	COG0519	Catalyzes the synthesis of GMP from XMP
HJD23_RS13785	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HJD23_RS13790	COG1611	Belongs to the LOG family
HJD23_RS13795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HJD23_RS13830	COG2197	response regulator
HJD23_RS13835	COG4585	Histidine kinase
HJD23_RS13845	COG1131	(ABC) transporter
HJD23_RS13860	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HJD23_RS13875	COG4608	Belongs to the ABC transporter superfamily
HJD23_RS13885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HJD23_RS13890	COG0601	transmembrane transport
HJD23_RS13905	COG2801	Transposase and inactivated derivatives
HJD23_RS13905	COG3415	Transposase
HJD23_RS13910	COG4608	Belongs to the ABC transporter superfamily
HJD23_RS13915	COG0444	Belongs to the ABC transporter superfamily
HJD23_RS13920	COG0601	transmembrane transport
HJD23_RS13925	COG0747	negative chemotaxis
HJD23_RS13955	COG1053	succinate dehydrogenase
HJD23_RS14085	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HJD23_RS14095	COG0012	GTP binding
HJD23_RS14110	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HJD23_RS14115	COG1570	exodeoxyribonuclease VII activity
HJD23_RS14120	COG1722	exodeoxyribonuclease VII activity
HJD23_RS14125	COG0778	Nitroreductase
HJD23_RS14150	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HJD23_RS14150	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HJD23_RS14155	COG0114	fumarate hydratase activity
HJD23_RS14170	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HJD23_RS14190	COG1136	(ABC) transporter
HJD23_RS14205	COG0450	alkyl hydroperoxide reductase
HJD23_RS14210	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HJD23_RS14225	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HJD23_RS14230	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HJD23_RS14245	COG2318	DinB family
HJD23_RS14320	COG2197	response regulator
HJD23_RS14355	COG2894	cell division
HJD23_RS14425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HJD23_RS14475	COG2610	gluconate transmembrane transporter activity
HJD23_RS14480	COG0251	oxidation-reduction process
HJD23_RS14485	COG1414	Transcriptional regulator
HJD23_RS14500	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HJD23_RS14515	COG0436	Aminotransferase
HJD23_RS14555	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HJD23_RS14565	COG1309	transcriptional regulator
HJD23_RS14595	COG1331	Highly conserved protein containing a thioredoxin domain
HJD23_RS14610	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HJD23_RS14620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HJD23_RS14635	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HJD23_RS14640	COG2255	four-way junction helicase activity
HJD23_RS14645	COG1595	DNA-templated transcription, initiation
HJD23_RS14665	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HJD23_RS14685	COG1064	alcohol dehydrogenase
HJD23_RS14710	COG1136	(ABC) transporter
HJD23_RS14740	COG2986	histidine ammonia-lyase
HJD23_RS14750	COG1024	Enoyl-CoA hydratase
HJD23_RS14760	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HJD23_RS14770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HJD23_RS14785	COG0424	maF-like protein
HJD23_RS14795	COG4770	biotin carboxylase activity
HJD23_RS14825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HJD23_RS14845	COG1012	belongs to the aldehyde dehydrogenase family
HJD23_RS14850	COG1012	belongs to the aldehyde dehydrogenase family
HJD23_RS14855	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HJD23_RS14895	COG3655	Transcriptional regulator
HJD23_RS14910	COG1595	DNA-templated transcription, initiation
HJD23_RS14915	COG0745	RESPONSE REGULATOR receiver
HJD23_RS14920	COG2205	protein histidine kinase activity
HJD23_RS14945	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HJD23_RS14955	COG0583	DNA-binding transcription factor activity
HJD23_RS14960	COG2814	Major facilitator Superfamily
HJD23_RS15015	COG1744	ABC transporter substrate-binding protein PnrA-like
HJD23_RS15020	COG1473	amidohydrolase
HJD23_RS15020	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HJD23_RS15025	COG2226	methyltransferase
HJD23_RS15035	COG2089	acid synthase
HJD23_RS15050	COG1216	Glycosyl transferase, family 2
HJD23_RS15065	COG0463	Glycosyl transferase, family 2
HJD23_RS15105	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HJD23_RS15130	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HJD23_RS15130	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HJD23_RS15145	COG1595	DNA-templated transcription, initiation
HJD23_RS15185	COG0501	Belongs to the peptidase M48B family
HJD23_RS15255	COG2009	succinate dehydrogenase
HJD23_RS15265	COG1053	succinate dehydrogenase
HJD23_RS15310	COG2409	Drug exporters of the RND superfamily
HJD23_RS15315	COG0745	RESPONSE REGULATOR receiver
HJD23_RS15320	COG2205	protein histidine kinase activity
HJD23_RS15330	COG1408	metallophosphoesterase
HJD23_RS15345	COG1295	ribonuclease BN
HJD23_RS15370	COG0180	Tryptophanyl-tRNA synthetase
HJD23_RS15390	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HJD23_RS15395	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HJD23_RS15400	COG0754	glutathionylspermidine amidase activity
HJD23_RS15410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HJD23_RS15415	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HJD23_RS15425	COG4176	ABC-type proline glycine betaine transport system permease component
HJD23_RS15430	COG4175	Glycine betaine
HJD23_RS15430	COG0517	IMP dehydrogenase activity
HJD23_RS15440	COG1012	belongs to the aldehyde dehydrogenase family
HJD23_RS15450	COG0039	L-malate dehydrogenase activity
HJD23_RS15465	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HJD23_RS15545	COG0138	bifunctional purine biosynthesis protein purh
HJD23_RS15575	COG0045	succinate-CoA ligase (ADP-forming) activity
HJD23_RS15585	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HJD23_RS15590	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HJD23_RS15595	COG0714	Associated with various cellular activities
HJD23_RS15610	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HJD23_RS15610	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HJD23_RS15645	COG2197	response regulator
HJD23_RS15685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HJD23_RS15685	COG0519	Catalyzes the synthesis of GMP from XMP
HJD23_RS15705	COG1012	belongs to the aldehyde dehydrogenase family
HJD23_RS15710	COG0515	serine threonine protein kinase
HJD23_RS15715	COG0515	serine threonine protein kinase
HJD23_RS15720	COG0515	serine threonine protein kinase
HJD23_RS15725	COG0515	serine threonine protein kinase
HJD23_RS15730	COG2815	serine threonine protein kinase
HJD23_RS15730	COG0515	serine threonine protein kinase
HJD23_RS15740	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HJD23_RS15750	COG0516	GMP reductase activity
HJD23_RS15760	COG1595	DNA-templated transcription, initiation
HJD23_RS15775	COG0583	DNA-binding transcription factor activity
HJD23_RS15785	COG2132	Multicopper oxidase
HJD23_RS15790	COG4221	oxidoreductase activity
HJD23_RS15800	COG0459	protein refolding
HJD23_RS15810	COG0726	polysaccharide deacetylase
HJD23_RS15815	COG0726	polysaccharide deacetylase
HJD23_RS15845	COG1653	transport
HJD23_RS15850	COG1175	transmembrane transport
HJD23_RS15865	COG0501	Belongs to the peptidase M48B family
HJD23_RS15880	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HJD23_RS15905	COG0802	atpase or kinase
HJD23_RS15915	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HJD23_RS15935	COG0736	holo-[acyl-carrier-protein] synthase activity
HJD23_RS16020	COG2801	Transposase and inactivated derivatives
HJD23_RS16025	COG2801	Transposase and inactivated derivatives
HJD23_RS16035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HJD23_RS16040	COG1072	(Pantothenic acid kinase))
HJD23_RS16045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HJD23_RS16050	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HJD23_RS16055	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HJD23_RS16070	COG0101	tRNA pseudouridine synthase activity
HJD23_RS16075	COG0203	ribosomal protein L17
HJD23_RS16080	COG0202	RNA polymerase activity
HJD23_RS16085	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HJD23_RS16090	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HJD23_RS16095	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HJD23_RS16100	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HJD23_RS16110	COG0563	adenylate kinase activity
HJD23_RS16120	COG0200	Binds to the 23S rRNA
HJD23_RS16125	COG1841	ribosomal large subunit assembly
HJD23_RS16130	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HJD23_RS16135	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HJD23_RS16140	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HJD23_RS16145	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HJD23_RS16150	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HJD23_RS16155	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HJD23_RS16160	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HJD23_RS16165	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HJD23_RS16170	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HJD23_RS16175	COG0255	Belongs to the universal ribosomal protein uL29 family
HJD23_RS16180	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HJD23_RS16185	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HJD23_RS16190	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HJD23_RS16195	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HJD23_RS16200	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HJD23_RS16205	COG0089	rRNA binding
HJD23_RS16210	COG0088	Forms part of the polypeptide exit tunnel
HJD23_RS16215	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HJD23_RS16220	COG0051	transcription antitermination factor activity, RNA binding
HJD23_RS16225	COG2409	Drug exporters of the RND superfamily
HJD23_RS16230	COG4585	Histidine kinase
HJD23_RS16285	COG2755	lipolytic protein G-D-S-L family
HJD23_RS16285	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HJD23_RS16295	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HJD23_RS16300	COG0049	tRNA binding
HJD23_RS16305	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HJD23_RS16315	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HJD23_RS16320	COG0085	RNA polymerase activity
HJD23_RS16340	COG0081	regulation of translation
HJD23_RS16345	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HJD23_RS16350	COG0250	Participates in transcription elongation, termination and antitermination
HJD23_RS16365	COG0436	Aminotransferase
HJD23_RS16370	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HJD23_RS16375	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HJD23_RS16385	COG2030	dehydratase
HJD23_RS16390	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HJD23_RS16410	COG0702	epimerase
HJD23_RS16425	COG1666	GTP binding
HJD23_RS16430	COG2261	transglycosylase associated protein
HJD23_RS16440	COG3304	Inner membrane component domain
HJD23_RS16450	COG0326	Molecular chaperone. Has ATPase activity
HJD23_RS16490	COG2186	Transcriptional regulator
HJD23_RS16525	COG0501	Belongs to the peptidase M48B family
HJD23_RS16530	COG1007	ATP synthesis coupled electron transport
HJD23_RS16540	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HJD23_RS16545	COG0713	ATP synthesis coupled electron transport
HJD23_RS16550	COG0839	Belongs to the complex I subunit 6 family
HJD23_RS16555	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HJD23_RS16560	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HJD23_RS16565	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HJD23_RS16570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HJD23_RS16575	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HJD23_RS16580	COG4585	Histidine kinase
HJD23_RS16595	COG0674	pyruvate-flavodoxin oxidoreductase activity
HJD23_RS16595	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HJD23_RS16600	COG1013	pyruvate-flavodoxin oxidoreductase activity
HJD23_RS16605	COG1733	regulation of RNA biosynthetic process
HJD23_RS16610	COG0702	epimerase
HJD23_RS16625	COG1733	regulation of RNA biosynthetic process
HJD23_RS16645	COG0655	NAD(P)H dehydrogenase (quinone) activity
HJD23_RS16685	COG0561	phosphatase activity
HJD23_RS16710	COG1007	ATP synthesis coupled electron transport
HJD23_RS16720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HJD23_RS16725	COG0713	ATP synthesis coupled electron transport
HJD23_RS16730	COG0839	Belongs to the complex I subunit 6 family
HJD23_RS16735	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HJD23_RS16740	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HJD23_RS16745	COG1034	ATP synthesis coupled electron transport
HJD23_RS16750	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HJD23_RS16760	COG0649	NAD binding
HJD23_RS16765	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HJD23_RS16770	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HJD23_RS16780	COG1388	LysM domain
HJD23_RS16780	COG0791	NLP P60 protein
HJD23_RS16780	COG3103	Sh3 type 3 domain protein
HJD23_RS16805	COG2226	methyltransferase
HJD23_RS16815	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HJD23_RS16825	COG0515	serine threonine protein kinase
HJD23_RS16825	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HJD23_RS16830	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HJD23_RS16840	COG2226	methyltransferase
HJD23_RS16855	COG1309	transcriptional regulator
HJD23_RS16860	COG1301	dicarboxylic acid transport
HJD23_RS16875	COG1573	uracil-dna glycosylase
HJD23_RS16880	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HJD23_RS16890	COG0163	prenyltransferase activity
HJD23_RS16900	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HJD23_RS16930	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HJD23_RS16935	COG1333	cytochrome c biogenesis protein
HJD23_RS16940	COG0785	Cytochrome C biogenesis protein
HJD23_RS16955	COG0406	alpha-ribazole phosphatase activity
HJD23_RS16960	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HJD23_RS16980	COG1968	undecaprenyl-diphosphatase activity
HJD23_RS17000	COG2205	protein histidine kinase activity
HJD23_RS17015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HJD23_RS17020	COG1742	UPF0060 membrane protein
HJD23_RS17030	COG1690	Belongs to the RtcB family
HJD23_RS17050	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HJD23_RS17055	COG0018	arginyl-trna synthetase
HJD23_RS17095	COG3152	Membrane
HJD23_RS17120	COG2971	BadF BadG BcrA BcrD
HJD23_RS17125	COG1940	carbohydrate kinase activity
HJD23_RS17135	COG1175	transmembrane transport
HJD23_RS17140	COG0395	ABC-type sugar transport system, permease component
HJD23_RS17155	COG0113	porphobilinogen synthase activity
HJD23_RS17160	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HJD23_RS17160	COG1648	precorrin-2 dehydrogenase activity
HJD23_RS17165	COG0181	hydroxymethylbilane synthase activity
HJD23_RS17170	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HJD23_RS17175	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HJD23_RS17225	COG0123	including yeast histone deacetylase and acetoin utilization protein
HJD23_RS17235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HJD23_RS17255	COG0180	Tryptophanyl-tRNA synthetase
HJD23_RS17260	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HJD23_RS17270	COG1129	ABC transporter
HJD23_RS17270	COG0842	Transport permease protein
HJD23_RS17285	COG4991	sh3 domain protein
HJD23_RS17290	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HJD23_RS17290	COG0515	serine threonine protein kinase
HJD23_RS17295	COG0129	dihydroxy-acid dehydratase activity
HJD23_RS17300	COG1309	transcriptional regulator
HJD23_RS17305	COG1082	Xylose isomerase domain protein TIM barrel
HJD23_RS17310	COG0248	Ppx GppA phosphatase
HJD23_RS17330	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HJD23_RS17340	COG1194	a g-specific adenine glycosylase
HJD23_RS17345	COG1595	DNA-templated transcription, initiation
HJD23_RS17355	COG0745	RESPONSE REGULATOR receiver
HJD23_RS17360	COG2205	protein histidine kinase activity
HJD23_RS17365	COG0346	lactoylglutathione lyase activity
HJD23_RS17385	COG0739	heme binding
HJD23_RS17415	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HJD23_RS17435	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HJD23_RS17445	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HJD23_RS17450	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HJD23_RS17470	COG1660	Displays ATPase and GTPase activities
HJD23_RS17475	COG2197	response regulator
HJD23_RS17490	COG0649	NAD binding
HJD23_RS17525	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HJD23_RS17545	COG0302	gtp cyclohydrolase
HJD23_RS17560	COG0037	tRNA processing
HJD23_RS17570	COG2027	D-alanyl-D-alanine carboxypeptidase
HJD23_RS17575	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HJD23_RS17590	COG0789	Transcriptional regulator
HJD23_RS17600	COG1012	belongs to the aldehyde dehydrogenase family
HJD23_RS17620	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HJD23_RS17630	COG0254	rRNA binding
HJD23_RS17635	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HJD23_RS17640	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HJD23_RS17645	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HJD23_RS17670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HJD23_RS17670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HJD23_RS17675	COG3903	Transcriptional regulator
HJD23_RS17675	COG3629	intracellular signal transduction
HJD23_RS17680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HJD23_RS17705	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HJD23_RS17710	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HJD23_RS17715	COG1754	DNA topoisomerase type I activity
HJD23_RS17715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HJD23_RS17730	COG2890	protein-(glutamine-N5) methyltransferase activity
HJD23_RS17740	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HJD23_RS17745	COG2172	sigma factor antagonist activity
HJD23_RS17750	COG1366	Belongs to the anti-sigma-factor antagonist family
HJD23_RS17755	COG1111	helicase
HJD23_RS17755	COG1205	dead DEAH box helicase
HJD23_RS17825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HJD23_RS17830	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HJD23_RS17840	COG0596	Alpha beta hydrolase
HJD23_RS17870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HJD23_RS17895	COG0003	Pfam Anion-transporting ATPase
HJD23_RS17905	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HJD23_RS17915	COG1408	metallophosphoesterase
HJD23_RS17940	COG3629	intracellular signal transduction
HJD23_RS17940	COG3903	Transcriptional regulator
HJD23_RS17960	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HJD23_RS18030	COG1201	RNA secondary structure unwinding
HJD23_RS18155	COG0515	serine threonine protein kinase
HJD23_RS18155	COG2815	serine threonine protein kinase
HJD23_RS18175	COG0596	Alpha beta hydrolase
HJD23_RS18195	COG0640	Transcriptional regulator
HJD23_RS18220	COG1733	regulation of RNA biosynthetic process
HJD23_RS18240	COG0644	oxidoreductase
HJD23_RS18265	COG2890	protein-(glutamine-N5) methyltransferase activity
HJD23_RS18290	COG0288	reversible hydration of carbon dioxide
HJD23_RS18310	COG2801	Transposase and inactivated derivatives
HJD23_RS18335	COG0463	Glycosyl transferase, family 2
HJD23_RS18345	COG4249	Peptidase C14 caspase catalytic subunit p20
HJD23_RS18345	COG2319	Wd-40 repeat
HJD23_RS18380	COG0701	Predicted permease
HJD23_RS18405	COG1595	DNA-templated transcription, initiation
HJD23_RS18425	COG2205	protein histidine kinase activity
HJD23_RS18435	COG0384	phenazine biosynthesis protein PhzF
HJD23_RS18445	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HJD23_RS18450	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HJD23_RS18465	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HJD23_RS18465	COG0515	serine threonine protein kinase
HJD23_RS18475	COG0693	protein deglycase activity
HJD23_RS18485	COG1802	Transcriptional regulator
HJD23_RS18515	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HJD23_RS18535	COG1131	(ABC) transporter
HJD23_RS18540	COG3559	Exporter of polyketide antibiotics
HJD23_RS18575	COG2197	response regulator
HJD23_RS18580	COG4585	Histidine kinase
HJD23_RS18585	COG2197	response regulator
HJD23_RS18615	COG3844	kynureninase activity
HJD23_RS18630	COG0477	Major facilitator Superfamily
HJD23_RS18635	COG0191	fructose-bisphosphate aldolase activity
HJD23_RS18640	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HJD23_RS18655	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HJD23_RS18685	COG0542	response to heat
HJD23_RS18705	COG4213	ABC transporter substrate-binding protein
HJD23_RS18710	COG0789	Transcriptional regulator
HJD23_RS18715	COG0484	heat shock protein binding
HJD23_RS18720	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HJD23_RS18725	COG0443	Heat shock 70 kDa protein
HJD23_RS18730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HJD23_RS18735	COG2181	nitrate reductase activity
HJD23_RS18735	COG0247	lactate metabolic process
HJD23_RS18740	COG1131	(ABC) transporter
HJD23_RS18750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HJD23_RS18755	COG1120	ATPase activity
HJD23_RS18760	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HJD23_RS18765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HJD23_RS18795	COG1595	DNA-templated transcription, initiation
HJD23_RS18805	COG1131	(ABC) transporter
HJD23_RS18835	COG0513	Belongs to the DEAD box helicase family
HJD23_RS18840	COG1278	Cold shock
HJD23_RS18860	COG2197	response regulator
HJD23_RS18895	COG4213	ABC transporter substrate-binding protein
HJD23_RS18925	COG0300	oxidoreductase activity
HJD23_RS18935	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HJD23_RS18945	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HJD23_RS18950	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HJD23_RS18955	COG2080	2 iron, 2 sulfur cluster binding
HJD23_RS18960	COG1404	Belongs to the peptidase S8 family
HJD23_RS18960	COG4412	M6 family metalloprotease domain protein
HJD23_RS18965	COG1846	Transcriptional regulator
HJD23_RS18980	COG1309	transcriptional regulator
HJD23_RS18985	COG0667	Aldo Keto reductase
HJD23_RS19060	COG0671	phosphoesterase, PA-phosphatase related
HJD23_RS19065	COG0671	phosphoesterase, PA-phosphatase related
HJD23_RS19100	COG1136	(ABC) transporter
HJD23_RS19110	COG2197	response regulator
HJD23_RS19150	COG3250	beta-galactosidase activity
HJD23_RS19160	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
HJD23_RS19180	COG1132	(ABC) transporter
HJD23_RS19190	COG4585	Histidine kinase
HJD23_RS19195	COG2197	response regulator
HJD23_RS19225	COG1231	oxidoreductase activity
HJD23_RS19230	COG2124	cytochrome p450
HJD23_RS19230	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HJD23_RS19245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HJD23_RS19260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HJD23_RS19285	COG1175	transmembrane transport
HJD23_RS19335	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HJD23_RS19355	COG0717	Belongs to the dCTP deaminase family
HJD23_RS19360	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HJD23_RS19450	COG0464	growth
HJD23_RS19490	COG1231	oxidoreductase activity
HJD23_RS19515	COG2367	Beta-lactamase
HJD23_RS19520	COG0768	penicillin binding
HJD23_RS19525	COG0583	DNA-binding transcription factor activity
HJD23_RS19545	COG3903	Transcriptional regulator
HJD23_RS19545	COG3629	intracellular signal transduction
HJD23_RS19580	COG0366	Alpha amylase catalytic
HJD23_RS19585	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HJD23_RS19600	COG1957	nucleoside hydrolase
HJD23_RS19605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HJD23_RS19625	COG1396	sequence-specific DNA binding
HJD23_RS19665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HJD23_RS19670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HJD23_RS19675	COG1289	transmembrane transporter activity
HJD23_RS19690	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HJD23_RS19705	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HJD23_RS19720	COG1741	Belongs to the pirin family
HJD23_RS19735	COG1960	acyl-CoA dehydrogenase activity
HJD23_RS19740	COG1362	aminopeptidase activity
HJD23_RS19785	COG2814	Major facilitator Superfamily
HJD23_RS19800	COG0508	dehydrogenase complex catalyzes the overall conversion of
HJD23_RS19805	COG0022	dehydrogenase e1 component
HJD23_RS19820	COG0515	serine threonine protein kinase
HJD23_RS19825	COG0515	serine threonine protein kinase
HJD23_RS19840	COG0604	alcohol dehydrogenase
HJD23_RS19840	COG3321	synthase
HJD23_RS19840	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS19865	COG0303	'Molybdopterin
HJD23_RS19890	COG1522	sequence-specific DNA binding
HJD23_RS19895	COG1309	transcriptional regulator
HJD23_RS19900	COG1250	3-hydroxyacyl-CoA dehydrogenase
HJD23_RS19925	COG3396	Phenylacetate-CoA oxygenase
HJD23_RS19930	COG3460	Phenylacetate-CoA oxygenase
HJD23_RS19935	COG3396	Phenylacetate-CoA oxygenase
HJD23_RS19940	COG2151	metal-sulfur cluster biosynthetic enzyme
HJD23_RS19945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HJD23_RS19985	COG0604	alcohol dehydrogenase
HJD23_RS19985	COG3321	synthase
HJD23_RS20000	COG0477	Major facilitator Superfamily
HJD23_RS20010	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HJD23_RS20025	COG1136	(ABC) transporter
HJD23_RS20025	COG0577	efflux transmembrane transporter activity
HJD23_RS20030	COG1136	(ABC) transporter
HJD23_RS20030	COG0577	efflux transmembrane transporter activity
HJD23_RS20040	COG0745	RESPONSE REGULATOR receiver
HJD23_RS20045	COG5002	protein histidine kinase activity
HJD23_RS20065	COG1136	(ABC) transporter
HJD23_RS20075	COG3629	intracellular signal transduction
HJD23_RS20075	COG3903	Transcriptional regulator
HJD23_RS20080	COG0596	Alpha beta hydrolase
HJD23_RS20125	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS20145	COG2267	carboxylic ester hydrolase activity
HJD23_RS20200	COG2197	response regulator
HJD23_RS20235	COG1716	ATPase activity
HJD23_RS20240	COG1716	ATPase activity
HJD23_RS20260	COG0515	serine threonine protein kinase
HJD23_RS20265	COG3764	Sortase (surface protein transpeptidase)
HJD23_RS20270	COG3764	Sortase (surface protein transpeptidase)
HJD23_RS20285	COG3764	Sortase (surface protein transpeptidase)
HJD23_RS20300	COG0705	Rhomboid family
HJD23_RS20355	COG0515	serine threonine protein kinase
HJD23_RS20405	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HJD23_RS20410	COG0187	DNA topoisomerase II activity
HJD23_RS20415	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HJD23_RS20420	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HJD23_RS20425	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HJD23_RS20430	COG0592	DNA-directed DNA polymerase activity
HJD23_RS20435	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HJD23_RS20440	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HJD23_RS20445	COG0594	ribonuclease P activity
HJD23_RS20450	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HJD23_RS20455	COG0706	membrane insertase activity
HJD23_RS20465	COG0357	Ribosomal RNA small subunit methyltransferase G
HJD23_RS20470	COG1192	Involved in chromosome partitioning
HJD23_RS20485	COG3118	belongs to the thioredoxin family
HJD23_RS20490	COG0492	ferredoxin-NADP+ reductase activity
HJD23_RS20500	COG1595	DNA-templated transcription, initiation
HJD23_RS20505	COG2815	serine threonine protein kinase
HJD23_RS20505	COG0515	serine threonine protein kinase
HJD23_RS20520	COG0617	tRNA 3'-terminal CCA addition
HJD23_RS20545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HJD23_RS20570	COG0360	Binds together with S18 to 16S ribosomal RNA
HJD23_RS20575	COG0629	single-stranded DNA binding
HJD23_RS20580	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HJD23_RS20585	COG0359	binds to the 23S rRNA
HJD23_RS20595	COG0305	Participates in initiation and elongation during chromosome replication
HJD23_RS20615	COG2814	Major facilitator Superfamily
HJD23_RS20645	COG0626	cystathionine gamma-synthase activity
HJD23_RS20650	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HJD23_RS20655	COG1950	PFAM Membrane protein of
HJD23_RS20660	COG0662	Cupin 2, conserved barrel domain protein
HJD23_RS20685	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HJD23_RS20695	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HJD23_RS20700	COG1609	Transcriptional regulator
HJD23_RS20705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HJD23_RS20715	COG1271	oxidase subunit
HJD23_RS20720	COG1294	oxidase, subunit
HJD23_RS20725	COG4988	ABC transporter
HJD23_RS20730	COG0739	heme binding
HJD23_RS20735	COG0561	phosphatase activity
HJD23_RS20755	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HJD23_RS20775	COG1131	(ABC) transporter
HJD23_RS20805	COG0561	phosphatase activity
HJD23_RS20810	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HJD23_RS20820	COG2837	iron assimilation
HJD23_RS20825	COG1276	copper resistance
HJD23_RS20835	COG1999	signal sequence binding
HJD23_RS20855	COG0006	proline dipeptidase activity
HJD23_RS20875	COG0653	protein targeting
HJD23_RS20890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HJD23_RS20960	COG2188	Transcriptional regulator
HJD23_RS20965	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HJD23_RS20995	COG1595	DNA-templated transcription, initiation
HJD23_RS21000	COG0318	PFAM AMP-dependent synthetase and ligase
HJD23_RS21005	COG2814	Major facilitator Superfamily
HJD23_RS21010	COG1309	transcriptional regulator
HJD23_RS21020	COG0784	Response regulator, receiver
HJD23_RS21050	COG0489	protein tyrosine kinase activity
HJD23_RS21055	COG0438	transferase activity, transferring glycosyl groups
HJD23_RS21095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HJD23_RS21100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HJD23_RS21115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HJD23_RS21120	COG2801	Transposase and inactivated derivatives
HJD23_RS21125	COG2963	transposase activity
HJD23_RS21155	COG0596	Alpha beta hydrolase
HJD23_RS21170	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HJD23_RS21200	COG0745	RESPONSE REGULATOR receiver
HJD23_RS21205	COG2205	protein histidine kinase activity
HJD23_RS21215	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HJD23_RS21220	COG0477	Major facilitator Superfamily
HJD23_RS21230	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HJD23_RS21235	COG3467	pyridoxamine 5'-phosphate
HJD23_RS21245	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HJD23_RS21250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HJD23_RS21285	COG2353	YceI-like domain
HJD23_RS21290	COG0477	Major facilitator Superfamily
HJD23_RS21310	COG1191	sigma factor activity
HJD23_RS21315	COG1191	sigma factor activity
HJD23_RS21350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HJD23_RS21365	COG0667	Aldo Keto reductase
HJD23_RS21375	COG1940	carbohydrate kinase activity
HJD23_RS21390	COG1082	Xylose isomerase domain protein TIM barrel
HJD23_RS21395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HJD23_RS21410	COG0022	dehydrogenase e1 component
HJD23_RS21415	COG0508	dehydrogenase complex catalyzes the overall conversion of
HJD23_RS21420	COG2814	Major facilitator Superfamily
HJD23_RS21455	COG0433	COG0433 Predicted ATPase
HJD23_RS21470	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HJD23_RS21540	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS21585	COG3409	Peptidoglycan-binding domain 1 protein
HJD23_RS21650	COG0395	ABC-type sugar transport system, permease component
HJD23_RS21655	COG3345	alpha-galactosidase
HJD23_RS21665	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HJD23_RS21680	COG0443	Heat shock 70 kDa protein
HJD23_RS21720	COG0515	serine threonine protein kinase
HJD23_RS21730	COG4977	sequence-specific DNA binding
HJD23_RS21750	COG2186	Transcriptional regulator
HJD23_RS21855	COG0151	Belongs to the GarS family
HJD23_RS21870	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HJD23_RS21880	COG2197	response regulator
HJD23_RS21915	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HJD23_RS21920	COG0047	phosphoribosylformylglycinamidine synthase activity
HJD23_RS21925	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HJD23_RS21945	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HJD23_RS21980	COG1643	Atp-dependent helicase
HJD23_RS22030	COG0513	Belongs to the DEAD box helicase family
HJD23_RS22050	COG1733	regulation of RNA biosynthetic process
HJD23_RS22105	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HJD23_RS22110	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HJD23_RS22130	COG3239	Fatty acid desaturase
HJD23_RS22175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HJD23_RS22180	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HJD23_RS22180	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HJD23_RS22190	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HJD23_RS22220	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HJD23_RS22225	COG0579	oxidoreductase
HJD23_RS22250	COG1252	NADH dehydrogenase
HJD23_RS22375	COG0675	Transposase, IS605 OrfB family
HJD23_RS22380	COG1196	nuclear chromosome segregation
HJD23_RS22380	COG0739	heme binding
HJD23_RS22380	COG0741	lytic transglycosylase activity
HJD23_RS22385	COG0671	phosphoesterase, PA-phosphatase related
HJD23_RS22390	COG0277	FAD linked oxidase domain protein
HJD23_RS22425	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HJD23_RS22430	COG0306	phosphate transporter
HJD23_RS22440	COG1937	Protein conserved in bacteria
HJD23_RS22465	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HJD23_RS22475	COG1131	(ABC) transporter
HJD23_RS22480	COG1725	Transcriptional regulator
HJD23_RS22485	COG0456	acetyltransferase
HJD23_RS22490	COG0737	Belongs to the 5'-nucleotidase family
HJD23_RS22535	COG3866	Pectate lyase
HJD23_RS22550	COG0745	RESPONSE REGULATOR receiver
HJD23_RS22565	COG1609	Transcriptional regulator
HJD23_RS22570	COG0745	RESPONSE REGULATOR receiver
HJD23_RS22595	COG2897	thiosulfate sulfurtransferase activity
HJD23_RS22620	COG3485	protocatechuate 3,4-dioxygenase
HJD23_RS22625	COG0735	belongs to the Fur family
HJD23_RS22630	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HJD23_RS22635	COG1490	D-aminoacyl-tRNA deacylase activity
HJD23_RS22645	COG4552	Acetyltransferase involved in intracellular survival and related
HJD23_RS22650	COG2188	Transcriptional regulator
HJD23_RS22660	COG2188	Transcriptional regulator
HJD23_RS22665	COG0546	phosphoglycolate phosphatase activity
HJD23_RS22700	COG1733	regulation of RNA biosynthetic process
HJD23_RS22710	COG2318	DinB family
HJD23_RS22715	COG2318	DinB family
HJD23_RS22725	COG2801	Transposase and inactivated derivatives
HJD23_RS22730	COG2801	Transposase and inactivated derivatives
HJD23_RS22770	COG0438	transferase activity, transferring glycosyl groups
HJD23_RS22780	COG2207	Transcriptional regulator
HJD23_RS22780	COG1917	Cupin 2, conserved barrel domain protein
HJD23_RS22795	COG0438	transferase activity, transferring glycosyl groups
HJD23_RS22800	COG0438	transferase activity, transferring glycosyl groups
HJD23_RS22805	COG0588	phosphoglycerate mutase activity
HJD23_RS22835	COG1725	Transcriptional regulator
HJD23_RS22860	COG5002	protein histidine kinase activity
HJD23_RS22875	COG1329	Transcriptional regulator
HJD23_RS22880	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HJD23_RS22885	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HJD23_RS22890	COG0215	cysteine-tRNA ligase activity
HJD23_RS22895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HJD23_RS22915	COG3842	ATPase activity
HJD23_RS22975	COG1595	DNA-templated transcription, initiation
HJD23_RS22985	COG3300	MHYT domain
HJD23_RS22985	COG5001	Diguanylate cyclase
HJD23_RS23025	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HJD23_RS23030	COG0463	Glycosyl transferase, family 2
HJD23_RS23050	COG0459	protein refolding
HJD23_RS23115	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HJD23_RS23120	COG1737	Transcriptional regulator
HJD23_RS23165	COG2319	Wd-40 repeat
HJD23_RS23165	COG4249	Peptidase C14 caspase catalytic subunit p20
HJD23_RS23175	COG3973	AAA domain
HJD23_RS23190	COG1061	Type III restriction enzyme res subunit
HJD23_RS23220	COG1278	Cold shock
HJD23_RS23225	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HJD23_RS23230	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HJD23_RS23240	COG2814	Major facilitator Superfamily
HJD23_RS23290	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HJD23_RS23300	COG2252	PERMEase
HJD23_RS23330	COG0667	Aldo Keto reductase
HJD23_RS23380	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HJD23_RS23390	COG1609	Transcriptional regulator
HJD23_RS23400	COG1175	transmembrane transport
HJD23_RS23405	COG0395	ABC-type sugar transport system, permease component
HJD23_RS23410	COG5006	permease, DMT superfamily
HJD23_RS23440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HJD23_RS23455	COG0318	PFAM AMP-dependent synthetase and ligase
HJD23_RS23470	COG0259	pyridoxamine-phosphate oxidase activity
HJD23_RS23490	COG4821	SIS domain
HJD23_RS23500	COG2945	thiolester hydrolase activity
HJD23_RS23500	COG0596	Alpha beta hydrolase
HJD23_RS23575	COG0318	PFAM AMP-dependent synthetase and ligase
HJD23_RS23585	COG1960	acyl-CoA dehydrogenase activity
HJD23_RS23590	COG1960	acyl-CoA dehydrogenase activity
HJD23_RS23605	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS23610	COG1960	acyl-CoA dehydrogenase activity
HJD23_RS23635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HJD23_RS23645	COG1024	Enoyl-CoA hydratase
HJD23_RS23655	COG2072	flavoprotein involved in K transport
HJD23_RS23680	COG0259	pyridoxamine-phosphate oxidase activity
HJD23_RS23725	COG1960	acyl-CoA dehydrogenase activity
HJD23_RS23735	COG1280	lysine exporter protein (LysE YggA)
HJD23_RS23740	COG1522	sequence-specific DNA binding
HJD23_RS23755	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HJD23_RS23755	COG0515	serine threonine protein kinase
HJD23_RS23760	COG1024	Enoyl-CoA hydratase
HJD23_RS23775	COG0318	PFAM AMP-dependent synthetase and ligase
HJD23_RS23810	COG0297	glycogen (starch) synthase activity
HJD23_RS23820	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HJD23_RS23835	COG2192	nodulation
HJD23_RS23840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HJD23_RS23850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HJD23_RS23900	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HJD23_RS23945	COG1051	belongs to the nudix hydrolase family
HJD23_RS23960	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HJD23_RS23980	COG1595	DNA-templated transcription, initiation
HJD23_RS24010	COG1686	Belongs to the peptidase S11 family
HJD23_RS24035	COG0386	Belongs to the glutathione peroxidase family
HJD23_RS24060	COG2198	Histidine kinase
HJD23_RS24060	COG0784	Response regulator, receiver
HJD23_RS24060	COG2205	protein histidine kinase activity
HJD23_RS24140	COG1335	isochorismatase
HJD23_RS24150	COG1335	isochorismatase
HJD23_RS24180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HJD23_RS24190	COG0477	Major facilitator Superfamily
HJD23_RS24235	COG2188	Transcriptional regulator
HJD23_RS24285	COG0582	viral genome integration into host DNA
HJD23_RS24330	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HJD23_RS24370	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HJD23_RS24410	COG4974	Belongs to the 'phage' integrase family
HJD23_RS24440	COG3345	alpha-galactosidase
HJD23_RS24450	COG1414	Transcriptional regulator
HJD23_RS24470	COG1846	Transcriptional regulator
HJD23_RS24475	COG3384	dioxygenase
HJD23_RS24480	COG1247	-acetyltransferase
HJD23_RS24500	COG0477	Major facilitator Superfamily
HJD23_RS24505	COG1349	DNA-binding transcription factor activity
HJD23_RS24515	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HJD23_RS24515	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HJD23_RS24515	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HJD23_RS24525	COG1376	ErfK ybiS ycfS ynhG family protein
HJD23_RS24545	COG1970	mechanosensitive ion channel activity
HJD23_RS24555	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HJD23_RS24565	COG0477	Major facilitator Superfamily
HJD23_RS24580	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HJD23_RS24585	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HJD23_RS24595	COG0315	cyclic pyranopterin monophosphate synthase activity
HJD23_RS24600	COG0521	Mo-molybdopterin cofactor biosynthetic process
HJD23_RS24600	COG0315	cyclic pyranopterin monophosphate synthase activity
HJD23_RS24605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HJD23_RS24625	COG0708	Exodeoxyribonuclease III
HJD23_RS24640	COG2072	flavoprotein involved in K transport
HJD23_RS24645	COG2267	carboxylic ester hydrolase activity
HJD23_RS24650	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS24660	COG0793	Belongs to the peptidase S41A family
HJD23_RS24660	COG4946	Tricorn protease homolog
HJD23_RS24670	COG2409	Drug exporters of the RND superfamily
HJD23_RS24690	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HJD23_RS24695	COG0442	prolyl-tRNA aminoacylation
HJD23_RS24745	COG0745	RESPONSE REGULATOR receiver
HJD23_RS24785	COG0475	glutathione-regulated potassium exporter activity
HJD23_RS24820	COG4770	biotin carboxylase activity
HJD23_RS24845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HJD23_RS24875	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS24875	COG0604	alcohol dehydrogenase
HJD23_RS24875	COG3321	synthase
HJD23_RS24880	COG0736	holo-[acyl-carrier-protein] synthase activity
HJD23_RS24885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HJD23_RS24910	COG1764	response to oxidative stress
HJD23_RS24915	COG1122	ATPase activity
HJD23_RS24925	COG0310	cobalt ion transport
HJD23_RS24960	COG0084	hydrolase, TatD family'
HJD23_RS24965	COG3584	3D domain protein
HJD23_RS24965	COG3583	domain protein
HJD23_RS24970	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HJD23_RS24975	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HJD23_RS24985	COG0488	(ABC) transporter
HJD23_RS25025	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HJD23_RS25035	COG2197	response regulator
HJD23_RS25045	COG4106	trans-aconitate 2-methyltransferase activity
HJD23_RS25055	COG1309	transcriptional regulator
HJD23_RS25065	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HJD23_RS25080	COG0193	aminoacyl-tRNA hydrolase activity
HJD23_RS25085	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HJD23_RS25090	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HJD23_RS25095	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HJD23_RS25105	COG4585	Histidine kinase
HJD23_RS25135	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HJD23_RS25145	COG0477	Major facilitator Superfamily
HJD23_RS25150	COG1136	(ABC) transporter
HJD23_RS25155	COG1136	(ABC) transporter
HJD23_RS25155	COG0577	efflux transmembrane transporter activity
HJD23_RS25165	COG1309	transcriptional regulator
HJD23_RS25240	COG0148	phosphopyruvate hydratase activity
HJD23_RS25260	COG1252	NADH dehydrogenase
HJD23_RS25275	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HJD23_RS25280	COG0577	efflux transmembrane transporter activity
HJD23_RS25285	COG1136	(ABC) transporter
HJD23_RS25300	COG1136	(ABC) transporter
HJD23_RS25300	COG0577	efflux transmembrane transporter activity
HJD23_RS25335	COG0183	Belongs to the thiolase family
HJD23_RS25340	COG2755	lipolytic protein G-D-S-L family
HJD23_RS25350	COG4591	ABC-type transport system involved in lipoprotein release permease component
HJD23_RS25350	COG1136	(ABC) transporter
HJD23_RS25355	COG1136	(ABC) transporter
HJD23_RS25375	COG2986	histidine ammonia-lyase
HJD23_RS25415	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HJD23_RS25420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HJD23_RS25430	COG1228	amidohydrolase
HJD23_RS25440	COG1191	sigma factor activity
HJD23_RS25445	COG1366	Belongs to the anti-sigma-factor antagonist family
HJD23_RS25475	COG3104	oligopeptide transport
HJD23_RS25480	COG0745	RESPONSE REGULATOR receiver
HJD23_RS25485	COG2205	protein histidine kinase activity
HJD23_RS25500	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HJD23_RS25530	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HJD23_RS25545	COG1316	TRANSCRIPTIONal
HJD23_RS25555	COG1316	TRANSCRIPTIONal
HJD23_RS25565	COG1316	TRANSCRIPTIONal
HJD23_RS25570	COG1316	TRANSCRIPTIONal
HJD23_RS25575	COG1316	TRANSCRIPTIONal
HJD23_RS25600	COG0778	Nitroreductase
HJD23_RS25600	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HJD23_RS25605	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HJD23_RS25645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HJD23_RS25650	COG2835	tetraacyldisaccharide 4'-kinase activity
HJD23_RS25660	COG1482	cell wall glycoprotein biosynthetic process
HJD23_RS25670	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HJD23_RS25710	COG0714	Associated with various cellular activities
HJD23_RS25735	COG0745	RESPONSE REGULATOR receiver
HJD23_RS25740	COG5002	protein histidine kinase activity
HJD23_RS25740	COG5000	phosphorelay sensor kinase activity
HJD23_RS25745	COG0823	Involved in the tonB-independent uptake of proteins
HJD23_RS25755	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HJD23_RS25760	COG2197	response regulator
HJD23_RS25765	COG3214	Protein conserved in bacteria
HJD23_RS25775	COG0653	protein targeting
HJD23_RS25800	COG2902	Dehydrogenase
HJD23_RS25805	COG1134	teichoic acid transport
HJD23_RS25835	COG1846	Transcriptional regulator
HJD23_RS25840	COG1764	response to oxidative stress
HJD23_RS25850	COG0395	ABC-type sugar transport system, permease component
HJD23_RS25865	COG1674	ftsk spoiiie
HJD23_RS25870	COG0515	serine threonine protein kinase
HJD23_RS25875	COG0515	serine threonine protein kinase
HJD23_RS25880	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HJD23_RS25895	COG2884	Cell division ATP-binding protein ftsE
HJD23_RS25905	COG0793	Belongs to the peptidase S41A family
HJD23_RS25910	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HJD23_RS25920	COG1609	Transcriptional regulator
HJD23_RS25925	COG1501	Belongs to the glycosyl hydrolase 31 family
HJD23_RS25945	COG2223	nitrite transmembrane transporter activity
HJD23_RS25970	COG3973	AAA domain
HJD23_RS25980	COG0776	regulation of translation
HJD23_RS25985	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HJD23_RS25990	COG1678	Uncharacterized ACR, COG1678
HJD23_RS26010	COG0395	ABC-type sugar transport system, permease component
HJD23_RS26015	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HJD23_RS26030	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HJD23_RS26070	COG1174	glycine betaine transport
HJD23_RS26085	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HJD23_RS26095	COG0277	FAD linked oxidase domain protein
HJD23_RS26130	COG1335	isochorismatase
HJD23_RS26140	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HJD23_RS26150	COG1113	amino acid transport
HJD23_RS26175	COG1234	tRNA 3'-trailer cleavage
HJD23_RS26180	COG1263	PTS System
HJD23_RS26190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HJD23_RS26195	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HJD23_RS26205	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HJD23_RS26235	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HJD23_RS26250	COG4555	ABC transporter
HJD23_RS26265	COG2733	membrane
HJD23_RS26350	COG0640	Transcriptional regulator
HJD23_RS26355	COG2249	NAD(P)H dehydrogenase (quinone) activity
HJD23_RS26370	COG0667	Aldo Keto reductase
HJD23_RS26380	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HJD23_RS26410	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HJD23_RS26445	COG0556	nucleotide-excision repair
HJD23_RS26480	COG3764	Sortase (surface protein transpeptidase)
HJD23_RS26490	COG0706	membrane insertase activity
HJD23_RS26490	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
HJD23_RS26525	COG4702	Belongs to the UPF0303 family
HJD23_RS26530	COG0673	inositol 2-dehydrogenase activity
HJD23_RS26535	COG1940	carbohydrate kinase activity
HJD23_RS26545	COG1595	DNA-templated transcription, initiation
HJD23_RS26555	COG1733	regulation of RNA biosynthetic process
HJD23_RS26620	COG2186	Transcriptional regulator
HJD23_RS26640	COG3397	chitin binding
HJD23_RS26655	COG1126	abc transporter atp-binding protein
HJD23_RS26660	COG0765	amino acid transport
HJD23_RS26665	COG0765	amino acid transport
HJD23_RS26670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HJD23_RS26700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HJD23_RS26755	COG0406	alpha-ribazole phosphatase activity
HJD23_RS26780	COG0745	RESPONSE REGULATOR receiver
HJD23_RS26790	COG3979	chitinase
HJD23_RS26805	COG0395	ABC-type sugar transport system, permease component
HJD23_RS26850	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HJD23_RS26855	COG4977	sequence-specific DNA binding
HJD23_RS26865	COG0589	response to stress
HJD23_RS26875	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HJD23_RS26905	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HJD23_RS26910	COG0076	glutamate decarboxylase activity
HJD23_RS26925	COG1960	acyl-CoA dehydrogenase activity
HJD23_RS26940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HJD23_RS26945	COG1309	transcriptional regulator
HJD23_RS26960	COG1946	Acyl-CoA thioesterase
HJD23_RS26975	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HJD23_RS26985	COG0028	Belongs to the TPP enzyme family
HJD23_RS27035	COG2356	endonuclease I
HJD23_RS27100	COG1472	Belongs to the glycosyl hydrolase 3 family
HJD23_RS27125	COG0456	acetyltransferase
HJD23_RS27125	COG1846	Transcriptional regulator
HJD23_RS27135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HJD23_RS27150	COG0535	radical SAM domain protein
HJD23_RS27185	COG0673	inositol 2-dehydrogenase activity
HJD23_RS27200	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HJD23_RS27205	COG1595	DNA-templated transcription, initiation
HJD23_RS27230	COG1869	D-ribose catabolic process
HJD23_RS27235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HJD23_RS27240	COG1879	ABC-type sugar transport system periplasmic component
HJD23_RS27245	COG1129	ABC transporter
HJD23_RS27300	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HJD23_RS27330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HJD23_RS27350	COG3718	enzyme involved in inositol metabolism
HJD23_RS27355	COG3962	Belongs to the TPP enzyme family
HJD23_RS27420	COG2801	Transposase and inactivated derivatives
HJD23_RS27440	COG2801	Transposase and inactivated derivatives
HJD23_RS27490	COG0728	peptidoglycan biosynthetic process
HJD23_RS27500	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HJD23_RS27515	COG2304	oxidoreductase activity
HJD23_RS27540	COG0629	single-stranded DNA binding
HJD23_RS27600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HJD23_RS27615	COG1486	melibiose metabolic process
HJD23_RS27620	COG0395	ABC-type sugar transport system, permease component
HJD23_RS27625	COG1175	transmembrane transport
HJD23_RS27630	COG1653	transport
HJD23_RS27645	COG0668	transmembrane transport
HJD23_RS27660	COG1136	(ABC) transporter
HJD23_RS27670	COG3291	Pkd domain containing protein
HJD23_RS27670	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HJD23_RS27695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HJD23_RS27805	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HJD23_RS27810	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HJD23_RS27815	COG1113	amino acid transport
HJD23_RS27820	COG1268	BioY protein
HJD23_RS27830	COG0515	serine threonine protein kinase
HJD23_RS27835	COG1113	amino acid transport
HJD23_RS27850	COG4552	Acetyltransferase involved in intracellular survival and related
HJD23_RS27920	COG1674	ftsk spoiiie
HJD23_RS27945	COG0544	peptidyl-prolyl cis-trans isomerase activity
HJD23_RS27950	COG0740	serine-type endopeptidase activity
HJD23_RS27955	COG0740	serine-type endopeptidase activity
HJD23_RS27960	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HJD23_RS27970	COG0525	valine-tRNA ligase activity
HJD23_RS27975	COG0285	dihydrofolate synthase activity
HJD23_RS27985	COG0105	UTP biosynthetic process
HJD23_RS27990	COG1077	Cell shape determining protein MreB Mrl
HJD23_RS28005	COG0768	penicillin binding
HJD23_RS28010	COG0772	Belongs to the SEDS family
HJD23_RS28045	COG2850	peptidyl-arginine hydroxylation
HJD23_RS28110	COG1530	ribonuclease E activity
HJD23_RS28115	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HJD23_RS28120	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HJD23_RS28125	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HJD23_RS28130	COG0438	transferase activity, transferring glycosyl groups
HJD23_RS28140	COG0438	transferase activity, transferring glycosyl groups
HJD23_RS28165	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HJD23_RS28175	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HJD23_RS28190	COG0501	Belongs to the peptidase M48B family
HJD23_RS28205	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HJD23_RS28215	COG0799	negative regulation of ribosome biogenesis
HJD23_RS28250	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HJD23_RS28260	COG0495	leucyl-tRNA aminoacylation
HJD23_RS28270	COG1307	EDD domain protein, DegV family
HJD23_RS28275	COG1555	photosystem II stabilization
HJD23_RS28275	COG1596	polysaccharide export
HJD23_RS28285	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HJD23_RS28305	COG0268	Binds directly to 16S ribosomal RNA
HJD23_RS28310	COG0481	GTPase activity
HJD23_RS28345	COG1420	regulation of RNA biosynthetic process
HJD23_RS28350	COG0484	heat shock protein binding
HJD23_RS28385	COG0793	Belongs to the peptidase S41A family
HJD23_RS28385	COG4946	Tricorn protease homolog
HJD23_RS28390	COG0537	adenosine 5'-monophosphoramidase activity
HJD23_RS28395	COG1234	tRNA 3'-trailer cleavage
HJD23_RS28400	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HJD23_RS28415	COG4948	Mandelate Racemase Muconate Lactonizing
HJD23_RS28425	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HJD23_RS28440	COG2315	Protein conserved in bacteria
HJD23_RS28450	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HJD23_RS28465	COG2723	6-phospho-beta-galactosidase activity
HJD23_RS28480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HJD23_RS28490	COG2409	Drug exporters of the RND superfamily
HJD23_RS28495	COG4585	Histidine kinase
HJD23_RS28500	COG2197	response regulator
HJD23_RS28510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HJD23_RS28515	COG4608	Belongs to the ABC transporter superfamily
HJD23_RS28520	COG0444	Belongs to the ABC transporter superfamily
HJD23_RS28530	COG0747	negative chemotaxis
HJD23_RS28540	COG1595	DNA-templated transcription, initiation
HJD23_RS28560	COG1381	Involved in DNA repair and RecF pathway recombination
HJD23_RS28565	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HJD23_RS28580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HJD23_RS28585	COG1121	(ABC) transporter
HJD23_RS28590	COG0803	Belongs to the bacterial solute-binding protein 9 family
HJD23_RS28590	COG3443	Belongs to the bacterial solute-binding protein 9 family
HJD23_RS28595	COG0423	glycine-tRNA ligase activity
HJD23_RS28605	COG0667	Aldo Keto reductase
HJD23_RS28620	COG0477	Major facilitator Superfamily
HJD23_RS28705	COG1940	carbohydrate kinase activity
HJD23_RS28705	COG1846	Transcriptional regulator
HJD23_RS28710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HJD23_RS28710	COG0574	Belongs to the PEP-utilizing enzyme family
HJD23_RS28715	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HJD23_RS28795	COG0642	Histidine kinase
HJD23_RS28800	COG0745	RESPONSE REGULATOR receiver
HJD23_RS28810	COG0659	secondary active sulfate transmembrane transporter activity
HJD23_RS28820	COG2146	nitrite reductase [NAD(P)H] activity
HJD23_RS28820	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HJD23_RS28825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HJD23_RS28850	COG0243	molybdopterin cofactor binding
HJD23_RS28855	COG2949	membrane
HJD23_RS28865	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HJD23_RS28875	COG0358	DNA primase activity
HJD23_RS28880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HJD23_RS28895	COG1070	Carbohydrate kinase
HJD23_RS28925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HJD23_RS28930	COG0569	domain protein
HJD23_RS28935	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HJD23_RS28955	COG1077	Cell shape determining protein MreB Mrl
HJD23_RS28960	COG0825	malonyl-CoA metabolic process
HJD23_RS28960	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HJD23_RS28965	COG0318	PFAM AMP-dependent synthetase and ligase
HJD23_RS29010	COG4981	capsule polysaccharide biosynthetic process
HJD23_RS29035	COG1234	tRNA 3'-trailer cleavage
HJD23_RS29045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HJD23_RS29050	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HJD23_RS29070	COG0529	Catalyzes the synthesis of activated sulfate
HJD23_RS29085	COG2409	Drug exporters of the RND superfamily
HJD23_RS29095	COG1309	transcriptional regulator
HJD23_RS29100	COG1414	Transcriptional regulator
HJD23_RS29105	COG3386	PFAM SMP-30 Gluconolaconase
HJD23_RS29135	COG1175	transmembrane transport
HJD23_RS29140	COG0395	ABC-type sugar transport system, permease component
HJD23_RS29165	COG3507	Belongs to the glycosyl hydrolase 43 family
HJD23_RS29170	COG3940	Belongs to the glycosyl hydrolase 43 family
HJD23_RS29205	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HJD23_RS29230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HJD23_RS29240	COG4214	carbohydrate transport
HJD23_RS29285	COG0438	transferase activity, transferring glycosyl groups
HJD23_RS29295	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HJD23_RS29320	COG2130	NADP-dependent
HJD23_RS29325	COG1764	response to oxidative stress
HJD23_RS29350	COG1309	transcriptional regulator
HJD23_RS29390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HJD23_RS29395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HJD23_RS29400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HJD23_RS29430	COG0789	Transcriptional regulator
HJD23_RS29435	COG0667	Aldo Keto reductase
HJD23_RS29450	COG1309	transcriptional regulator
HJD23_RS29455	COG0477	Major facilitator Superfamily
HJD23_RS29460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HJD23_RS29465	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HJD23_RS29510	COG1358	cellular component organization or biogenesis
HJD23_RS29560	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HJD23_RS29640	COG4122	O-methyltransferase activity
HJD23_RS29660	COG1819	glycosyl
HJD23_RS29675	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HJD23_RS29740	COG0183	Belongs to the thiolase family
HJD23_RS29745	COG2124	cytochrome p450
HJD23_RS29765	COG3845	ABC transporter
HJD23_RS29780	COG1657	PFAM Prenyltransferase squalene oxidase
HJD23_RS29785	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HJD23_RS29790	COG3290	protein histidine kinase activity
HJD23_RS29810	COG1309	transcriptional regulator
HJD23_RS29845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HJD23_RS29855	COG2247	cell wall binding repeat
HJD23_RS29855	COG0860	N-Acetylmuramoyl-L-alanine amidase
HJD23_RS29865	COG0477	Major facilitator Superfamily
HJD23_RS29885	COG2197	response regulator
HJD23_RS29890	COG2030	dehydratase
HJD23_RS29900	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS29915	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HJD23_RS29930	COG0800	Aldolase
HJD23_RS29935	COG3022	response to hydroperoxide
HJD23_RS30000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HJD23_RS30030	COG0252	asparaginase activity
HJD23_RS30080	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HJD23_RS30085	COG1011	Hydrolase
HJD23_RS30175	COG4106	trans-aconitate 2-methyltransferase activity
HJD23_RS30190	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HJD23_RS30245	COG1937	Protein conserved in bacteria
HJD23_RS30270	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HJD23_RS30345	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HJD23_RS30355	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HJD23_RS30370	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HJD23_RS30375	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HJD23_RS30380	COG1007	ATP synthesis coupled electron transport
HJD23_RS30390	COG0791	NLP P60 protein
HJD23_RS30430	COG2801	Transposase and inactivated derivatives
HJD23_RS30435	COG2801	Transposase and inactivated derivatives
HJD23_RS30500	COG4221	oxidoreductase activity
HJD23_RS30505	COG2080	2 iron, 2 sulfur cluster binding
HJD23_RS30510	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HJD23_RS30515	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HJD23_RS30590	COG0318	PFAM AMP-dependent synthetase and ligase
HJD23_RS30605	COG0514	ATP-dependent DNA helicase (RecQ)
HJD23_RS30625	COG0484	heat shock protein binding
HJD23_RS30640	COG1302	Protein conserved in bacteria
HJD23_RS30650	COG1131	(ABC) transporter
HJD23_RS30655	COG2353	YceI-like domain
HJD23_RS30665	COG2197	response regulator
HJD23_RS30670	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HJD23_RS30675	COG2814	Major facilitator Superfamily
HJD23_RS30685	COG3540	Alkaline phosphatase
HJD23_RS30695	COG0667	Aldo Keto reductase
HJD23_RS30705	COG2259	Doxx family
HJD23_RS30740	COG1120	ATPase activity
HJD23_RS30745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HJD23_RS30755	COG5398	heme oxygenase
HJD23_RS30795	COG1994	Peptidase M50
HJD23_RS30815	COG2318	DinB family
HJD23_RS30840	COG0174	glutamine synthetase
HJD23_RS30855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HJD23_RS30855	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HJD23_RS30860	COG2814	Major facilitator Superfamily
HJD23_RS30875	COG0477	Major facilitator Superfamily
HJD23_RS30880	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HJD23_RS30940	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HJD23_RS30950	COG1609	Transcriptional regulator
HJD23_RS30955	COG1653	transport
HJD23_RS30960	COG1175	transmembrane transport
HJD23_RS30965	COG3833	ABC-type maltose transport systems, permease component
HJD23_RS30970	COG0366	Alpha amylase catalytic
HJD23_RS31005	COG1309	transcriptional regulator
HJD23_RS31065	COG0501	Belongs to the peptidase M48B family
HJD23_RS31080	COG0174	glutamine synthetase
HJD23_RS31100	COG0662	Cupin 2, conserved barrel domain protein
HJD23_RS31110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HJD23_RS31115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HJD23_RS31150	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HJD23_RS31155	COG0321	lipoyl(octanoyl) transferase activity
HJD23_RS31170	COG1090	epimerase
HJD23_RS31175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HJD23_RS31200	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HJD23_RS31215	COG0508	dehydrogenase complex catalyzes the overall conversion of
HJD23_RS31220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HJD23_RS31225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HJD23_RS31235	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HJD23_RS31250	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HJD23_RS31270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HJD23_RS31275	COG2226	methyltransferase
HJD23_RS31295	COG4585	Histidine kinase
HJD23_RS31300	COG2197	response regulator
HJD23_RS31305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HJD23_RS31310	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HJD23_RS31330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HJD23_RS31340	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HJD23_RS31345	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HJD23_RS31355	COG1376	ErfK ybiS ycfS ynhG family protein
HJD23_RS31365	COG1845	cytochrome c oxidase, subunit III
HJD23_RS31370	COG2010	Cytochrome c
HJD23_RS31375	COG0723	plastoquinol--plastocyanin reductase activity
HJD23_RS31380	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HJD23_RS31385	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HJD23_RS31390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HJD23_RS31420	COG3103	Sh3 type 3 domain protein
HJD23_RS31420	COG0791	NLP P60 protein
HJD23_RS31420	COG1388	LysM domain
HJD23_RS31425	COG0791	NLP P60 protein
HJD23_RS31425	COG3883	PFAM NLP P60 protein
HJD23_RS31485	COG0003	Pfam Anion-transporting ATPase
HJD23_RS31495	COG1940	carbohydrate kinase activity
HJD23_RS31530	COG0205	6-phosphofructokinase activity
HJD23_RS31535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HJD23_RS31550	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HJD23_RS31560	COG2193	ferroxidase activity
HJD23_RS31565	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HJD23_RS31570	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HJD23_RS31575	COG0515	serine threonine protein kinase
HJD23_RS31575	COG2815	serine threonine protein kinase
HJD23_RS31580	COG2022	thiamine diphosphate biosynthetic process
HJD23_RS31590	COG2022	thiamine diphosphate biosynthetic process
HJD23_RS31590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HJD23_RS31610	COG0352	thiamine-phosphate diphosphorylase activity
HJD23_RS31625	COG1233	COG1233 Phytoene dehydrogenase and related
HJD23_RS31635	COG1309	transcriptional regulator
HJD23_RS31640	COG1511	domain protein
HJD23_RS31645	COG1121	(ABC) transporter
HJD23_RS31675	COG0714	Associated with various cellular activities
HJD23_RS31685	COG0275	rRNA processing
HJD23_RS31695	COG0768	penicillin binding
HJD23_RS31700	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HJD23_RS31705	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HJD23_RS31710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HJD23_RS31715	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HJD23_RS31725	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HJD23_RS31730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HJD23_RS31735	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HJD23_RS31750	COG1799	cell septum assembly
HJD23_RS31760	COG3599	regulation of cell shape
HJD23_RS31765	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HJD23_RS31775	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HJD23_RS31825	COG0587	DNA-directed DNA polymerase activity
HJD23_RS31835	COG1432	Conserved Protein
HJD23_RS31855	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HJD23_RS31860	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HJD23_RS31870	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HJD23_RS31875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HJD23_RS31880	COG0131	Imidazoleglycerol-phosphate dehydratase
HJD23_RS31890	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HJD23_RS31895	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HJD23_RS31900	COG0251	oxidation-reduction process
HJD23_RS31905	COG0107	imidazoleglycerol-phosphate synthase activity
HJD23_RS31915	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HJD23_RS31940	COG0134	indole-3-glycerol-phosphate synthase activity
HJD23_RS31945	COG0133	tryptophan synthase activity
HJD23_RS31950	COG0159	tryptophan synthase activity
HJD23_RS31960	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HJD23_RS31970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HJD23_RS31990	COG1397	ADP-ribosylglycohydrolase
HJD23_RS32000	COG0067	glutamate synthase
HJD23_RS32000	COG0070	glutamate synthase
HJD23_RS32000	COG0069	glutamate synthase activity
HJD23_RS32015	COG2304	oxidoreductase activity
HJD23_RS32020	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HJD23_RS32025	COG1960	acyl-CoA dehydrogenase activity
HJD23_RS32030	COG1960	acyl-CoA dehydrogenase activity
HJD23_RS32035	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS32040	COG1309	transcriptional regulator
HJD23_RS32065	COG1024	Enoyl-CoA hydratase
HJD23_RS32070	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS32075	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS32095	COG1605	Chorismate mutase
HJD23_RS32095	COG0287	Prephenate dehydrogenase
HJD23_RS32100	COG4566	intracellular signal transduction
HJD23_RS32120	COG0737	Belongs to the 5'-nucleotidase family
HJD23_RS32185	COG2050	protein possibly involved in aromatic compounds catabolism
HJD23_RS32220	COG1643	Atp-dependent helicase
HJD23_RS32225	COG2226	methyltransferase
HJD23_RS32240	COG0237	dephospho-CoA kinase activity
HJD23_RS32275	COG0675	Transposase, IS605 OrfB family
HJD23_RS32285	COG2267	carboxylic ester hydrolase activity
HJD23_RS32295	COG1802	Transcriptional regulator
HJD23_RS32300	COG1953	Uracil, thiamine, allantoin
HJD23_RS32350	COG0402	S-adenosylhomocysteine deaminase activity
HJD23_RS32365	COG1132	(ABC) transporter
HJD23_RS32395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HJD23_RS32400	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HJD23_RS32430	COG0598	Magnesium transport protein CorA
HJD23_RS32440	COG2313	pseudouridylate synthase activity
HJD23_RS32450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HJD23_RS32460	COG0556	nucleotide-excision repair
HJD23_RS32480	COG0477	Major facilitator Superfamily
HJD23_RS32485	COG1619	proteins homologs of microcin C7 resistance protein MccF
HJD23_RS32490	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HJD23_RS32505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HJD23_RS32525	COG0322	excinuclease ABC activity
HJD23_RS32530	COG1660	Displays ATPase and GTPase activities
HJD23_RS32535	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HJD23_RS32540	COG1481	regulation of sporulation
HJD23_RS32550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HJD23_RS32555	COG0126	phosphoglycerate kinase activity
HJD23_RS32560	COG0149	triose-phosphate isomerase activity
HJD23_RS32565	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HJD23_RS32575	COG0166	Belongs to the GPI family
HJD23_RS32590	COG1136	(ABC) transporter
HJD23_RS32595	COG1695	Transcriptional regulator
HJD23_RS32605	COG0366	Alpha amylase catalytic
HJD23_RS32615	COG1175	transmembrane transport
HJD23_RS32620	COG0395	ABC-type sugar transport system, permease component
HJD23_RS32630	COG0363	glucosamine-6-phosphate deaminase activity
HJD23_RS32645	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HJD23_RS32655	COG0109	protoheme IX farnesyltransferase activity
HJD23_RS32675	COG1612	heme a metabolic process
HJD23_RS32685	COG1131	(ABC) transporter
HJD23_RS32700	COG0719	Fe-S assembly protein
HJD23_RS32710	COG0396	ATPase activity
HJD23_RS32715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HJD23_RS32720	COG0822	iron-sulfur transferase activity
HJD23_RS32725	COG2151	metal-sulfur cluster biosynthetic enzyme
HJD23_RS32740	COG3226	Transcriptional regulator
HJD23_RS32745	COG2171	N-acyltransferase activity
HJD23_RS32755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HJD23_RS32815	COG1309	transcriptional regulator
HJD23_RS32825	COG1063	alcohol dehydrogenase
HJD23_RS32830	COG0395	ABC-type sugar transport system, permease component
HJD23_RS32850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HJD23_RS32855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HJD23_RS32880	COG1802	Transcriptional regulator
HJD23_RS32885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HJD23_RS32895	COG1175	transmembrane transport
HJD23_RS32900	COG0395	ABC-type sugar transport system, permease component
HJD23_RS32905	COG3866	Pectate lyase
HJD23_RS32920	COG3507	Belongs to the glycosyl hydrolase 43 family
HJD23_RS32925	COG3866	Pectate lyase
HJD23_RS32935	COG2755	lipolytic protein G-D-S-L family
HJD23_RS32940	COG3866	Pectate lyase
HJD23_RS32945	COG4677	pectinesterase activity
HJD23_RS32955	COG5297	Belongs to the glycosyl hydrolase family 6
HJD23_RS32965	COG1595	DNA-templated transcription, initiation
HJD23_RS32970	COG2252	PERMEase
HJD23_RS32975	COG0768	penicillin binding
HJD23_RS32980	COG1414	Transcriptional regulator
HJD23_RS33025	COG5285	phytanoyl-CoA dioxygenase
HJD23_RS33030	COG1917	Cupin 2, conserved barrel domain protein
HJD23_RS33035	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HJD23_RS33040	COG0456	acetyltransferase
HJD23_RS33045	COG2318	DinB family
HJD23_RS33050	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HJD23_RS33055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HJD23_RS33060	COG0765	amino acid transport
HJD23_RS33085	COG4209	transmembrane transport
HJD23_RS33090	COG0395	ABC-type sugar transport system, permease component
HJD23_RS33100	COG1609	Transcriptional regulator
HJD23_RS33115	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HJD23_RS33150	COG1797	cobyrinic acid a,c-diamide synthase activity
HJD23_RS33170	COG1492	cobalamin metabolic process
HJD23_RS33175	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HJD23_RS33195	COG0235	Class ii aldolase
HJD23_RS33225	COG0488	(ABC) transporter
HJD23_RS33235	COG1024	Enoyl-CoA hydratase
HJD23_RS33275	COG3387	PFAM Glycoside hydrolase 15-related
HJD23_RS33290	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HJD23_RS33325	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HJD23_RS33330	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HJD23_RS33350	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HJD23_RS33365	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS33380	COG2186	Transcriptional regulator
HJD23_RS33395	COG0588	phosphoglycerate mutase activity
HJD23_RS33400	COG0560	Phosphoserine phosphatase
HJD23_RS33400	COG3830	Belongs to the UPF0237 family
HJD23_RS33410	COG1716	ATPase activity
HJD23_RS33410	COG1131	(ABC) transporter
HJD23_RS33410	COG0842	Transport permease protein
HJD23_RS33420	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HJD23_RS33425	COG4221	oxidoreductase activity
HJD23_RS33430	COG4585	Histidine kinase
HJD23_RS33435	COG2197	response regulator
HJD23_RS33450	COG1119	ATPase activity
HJD23_RS33475	COG1881	PFAM PEBP family protein
HJD23_RS33485	COG2094	Belongs to the DNA glycosylase MPG family
HJD23_RS33515	COG0647	UMP catabolic process
HJD23_RS33520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HJD23_RS33525	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HJD23_RS33530	COG1120	ATPase activity
HJD23_RS33550	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HJD23_RS33555	COG0497	DNA recombination
HJD23_RS33580	COG3387	PFAM Glycoside hydrolase 15-related
HJD23_RS33585	COG0504	CTP synthase activity
HJD23_RS33590	COG0494	nUDIX hydrolase
HJD23_RS33600	COG0686	Belongs to the AlaDH PNT family
HJD23_RS33615	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HJD23_RS33620	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HJD23_RS33625	COG1187	pseudouridine synthase activity
HJD23_RS33650	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HJD23_RS33660	COG1160	GTP binding
HJD23_RS33690	COG0411	ABC transporter
HJD23_RS33710	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HJD23_RS33710	COG2755	lipolytic protein G-D-S-L family
HJD23_RS33720	COG0596	Alpha beta hydrolase
HJD23_RS33725	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HJD23_RS33735	COG0671	phosphoesterase, PA-phosphatase related
HJD23_RS33750	COG1960	acyl-CoA dehydrogenase activity
HJD23_RS33755	COG1799	cell septum assembly
HJD23_RS33785	COG0587	DNA-directed DNA polymerase activity
HJD23_RS33790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HJD23_RS33810	COG2226	methyltransferase
HJD23_RS33825	COG1725	Transcriptional regulator
HJD23_RS33855	COG1216	Glycosyl transferase, family 2
HJD23_RS33860	COG0463	Glycosyl transferase, family 2
HJD23_RS33875	COG2755	lipolytic protein G-D-S-L family
HJD23_RS33900	COG1595	DNA-templated transcription, initiation
HJD23_RS33915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HJD23_RS33925	COG2188	Transcriptional regulator
HJD23_RS33930	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HJD23_RS33940	COG1309	transcriptional regulator
HJD23_RS33945	COG0243	molybdopterin cofactor binding
HJD23_RS33950	COG2851	Citrate transporter
HJD23_RS34025	COG2226	methyltransferase
HJD23_RS34065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HJD23_RS34100	COG0477	Major facilitator Superfamily
HJD23_RS34110	COG0640	Transcriptional regulator
HJD23_RS34120	COG1960	acyl-CoA dehydrogenase activity
HJD23_RS34140	COG0789	Transcriptional regulator
HJD23_RS34160	COG3876	Protein conserved in bacteria
HJD23_RS34170	COG0318	PFAM AMP-dependent synthetase and ligase
HJD23_RS34200	COG2149	membrane
HJD23_RS34205	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HJD23_RS34230	COG1063	alcohol dehydrogenase
HJD23_RS34235	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS34245	COG3265	gluconokinase activity
HJD23_RS34250	COG2186	Transcriptional regulator
HJD23_RS34255	COG3012	SEC-C Motif Domain Protein
HJD23_RS34285	COG1222	aaa ATPase
HJD23_RS34365	COG0667	Aldo Keto reductase
HJD23_RS34375	COG0308	aminopeptidase N
HJD23_RS34390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HJD23_RS34420	COG0667	Aldo Keto reductase
HJD23_RS34425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HJD23_RS34435	COG0588	phosphoglycerate mutase activity
HJD23_RS34450	COG0215	cysteine-tRNA ligase activity
HJD23_RS34460	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HJD23_RS34465	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HJD23_RS34470	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HJD23_RS34475	COG1414	Transcriptional regulator
HJD23_RS34480	COG1410	methionine synthase
HJD23_RS34480	COG0646	methionine synthase
HJD23_RS34485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HJD23_RS34490	COG4166	transmembrane transport
HJD23_RS34500	COG2197	response regulator
HJD23_RS34510	COG1994	Peptidase M50
HJD23_RS34510	COG0517	IMP dehydrogenase activity
HJD23_RS34530	COG1222	aaa ATPase
HJD23_RS34535	COG4122	O-methyltransferase activity
HJD23_RS34550	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HJD23_RS34555	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HJD23_RS34560	COG1609	Transcriptional regulator
HJD23_RS34570	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HJD23_RS34575	COG0545	Peptidyl-prolyl cis-trans isomerase
HJD23_RS34605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HJD23_RS34610	COG0805	protein transport
HJD23_RS34660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HJD23_RS34675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HJD23_RS34690	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HJD23_RS34700	COG0174	glutamine synthetase
HJD23_RS34705	COG1012	belongs to the aldehyde dehydrogenase family
HJD23_RS34710	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS34750	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HJD23_RS34755	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HJD23_RS34760	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HJD23_RS34765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HJD23_RS34770	COG5002	protein histidine kinase activity
HJD23_RS34775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HJD23_RS34780	COG0072	phenylalanine-tRNA ligase activity
HJD23_RS34780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HJD23_RS34805	COG1649	PFAM Uncharacterised BCR, COG1649
HJD23_RS34815	COG0697	spore germination
HJD23_RS34845	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HJD23_RS34850	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HJD23_RS34855	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HJD23_RS34860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HJD23_RS34865	COG1438	arginine binding
HJD23_RS34870	COG0789	Transcriptional regulator
HJD23_RS34910	COG0137	argininosuccinate synthase activity
HJD23_RS34915	COG0165	Argininosuccinate lyase
HJD23_RS34930	COG0477	Major facilitator Superfamily
HJD23_RS34940	COG0714	Associated with various cellular activities
HJD23_RS34950	COG2205	protein histidine kinase activity
HJD23_RS34955	COG0318	PFAM AMP-dependent synthetase and ligase
HJD23_RS34955	COG0204	Acyl-transferase
HJD23_RS34960	COG0584	glycerophosphoryl diester phosphodiesterase
HJD23_RS34990	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HJD23_RS34995	COG2011	ABC-type metal ion transport system permease component
HJD23_RS35000	COG1464	Belongs to the NlpA lipoprotein family
HJD23_RS35015	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HJD23_RS35020	COG1648	precorrin-2 dehydrogenase activity
HJD23_RS35020	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HJD23_RS35135	COG1653	transport
HJD23_RS35140	COG1175	transmembrane transport
HJD23_RS35145	COG0395	ABC-type sugar transport system, permease component
HJD23_RS35185	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HJD23_RS35210	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HJD23_RS35215	COG1560	Kdo2-lipid A biosynthetic process
HJD23_RS35220	COG0438	transferase activity, transferring glycosyl groups
HJD23_RS35230	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HJD23_RS35235	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HJD23_RS35240	COG0217	transcriptional regulatory protein
HJD23_RS35245	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HJD23_RS35250	COG0632	four-way junction helicase activity
HJD23_RS35255	COG2255	four-way junction helicase activity
HJD23_RS35265	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HJD23_RS35270	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HJD23_RS35275	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HJD23_RS35280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HJD23_RS35285	COG1196	nuclear chromosome segregation
HJD23_RS35290	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HJD23_RS35300	COG0124	histidyl-tRNA synthetase
HJD23_RS35315	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HJD23_RS35330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HJD23_RS35335	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HJD23_RS35340	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HJD23_RS35345	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HJD23_RS35350	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HJD23_RS35355	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HJD23_RS35365	COG0006	proline dipeptidase activity
HJD23_RS35370	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HJD23_RS35375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HJD23_RS35385	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HJD23_RS35390	COG0540	Belongs to the ATCase OTCase family
HJD23_RS35395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HJD23_RS35405	COG0505	Belongs to the CarA family
HJD23_RS35410	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HJD23_RS35415	COG0167	dihydroorotate dehydrogenase activity
HJD23_RS35420	COG0284	orotidine-5'-phosphate decarboxylase activity
HJD23_RS35430	COG0194	GDP metabolic process
HJD23_RS35435	COG1758	RNA polymerase activity
HJD23_RS35445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HJD23_RS35460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HJD23_RS35470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HJD23_RS35475	COG2390	Transcriptional regulator
HJD23_RS35490	COG0531	amino acid
HJD23_RS35505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HJD23_RS35545	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HJD23_RS35545	COG0515	serine threonine protein kinase
HJD23_RS35560	COG0738	Major facilitator superfamily
HJD23_RS35565	COG1940	carbohydrate kinase activity
HJD23_RS35565	COG1846	Transcriptional regulator
HJD23_RS35570	COG1090	epimerase
HJD23_RS35585	COG3201	nicotinamide mononucleotide transporter
HJD23_RS35590	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HJD23_RS35590	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HJD23_RS35595	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HJD23_RS35600	COG0140	phosphoribosyl-ATP diphosphatase activity
HJD23_RS35605	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HJD23_RS35630	COG0572	uridine kinase
HJD23_RS35640	COG0582	viral genome integration into host DNA
HJD23_RS35730	COG1846	Transcriptional regulator
HJD23_RS35740	COG0305	Participates in initiation and elongation during chromosome replication
HJD23_RS36030	COG1388	LysM domain
HJD23_RS36030	COG4942	peptidase
HJD23_RS36065	COG4974	Belongs to the 'phage' integrase family
HJD23_RS36080	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HJD23_RS36140	COG1960	acyl-CoA dehydrogenase activity
HJD23_RS36170	COG0463	Glycosyl transferase, family 2
HJD23_RS36185	COG2270	Major facilitator Superfamily
HJD23_RS36230	COG0438	transferase activity, transferring glycosyl groups
HJD23_RS36240	COG1984	allophanate hydrolase subunit 2
HJD23_RS36250	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HJD23_RS36255	COG4336	lyase activity
HJD23_RS36260	COG2814	Major facilitator Superfamily
HJD23_RS36305	COG2018	Roadblock/LC7 domain
HJD23_RS36325	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HJD23_RS36340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HJD23_RS36360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HJD23_RS36370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HJD23_RS36400	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HJD23_RS36420	COG1716	ATPase activity
HJD23_RS36440	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HJD23_RS36450	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HJD23_RS36450	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HJD23_RS36485	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HJD23_RS36490	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HJD23_RS36495	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HJD23_RS36535	COG0384	phenazine biosynthesis protein PhzF
HJD23_RS36625	COG4166	transmembrane transport
HJD23_RS36630	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HJD23_RS36645	COG2318	DinB family
HJD23_RS36665	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HJD23_RS36680	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS36705	COG2801	Transposase and inactivated derivatives
HJD23_RS36710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HJD23_RS36715	COG0489	protein tyrosine kinase activity
HJD23_RS36730	COG0438	transferase activity, transferring glycosyl groups
HJD23_RS36740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HJD23_RS36750	COG0438	transferase activity, transferring glycosyl groups
HJD23_RS36760	COG0297	glycogen (starch) synthase activity
HJD23_RS36785	COG0438	transferase activity, transferring glycosyl groups
HJD23_RS36805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HJD23_RS36810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HJD23_RS36815	COG0438	transferase activity, transferring glycosyl groups
HJD23_RS36850	COG2801	Transposase and inactivated derivatives
HJD23_RS36895	COG2801	Transposase and inactivated derivatives
HJD23_RS36935	COG0596	Alpha beta hydrolase
HJD23_RS36945	COG1968	undecaprenyl-diphosphatase activity
HJD23_RS36970	COG0183	Belongs to the thiolase family
HJD23_RS36985	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HJD23_RS37030	COG0110	maltose O-acetyltransferase activity
HJD23_RS37055	COG0640	Transcriptional regulator
HJD23_RS37065	COG1832	CoA-binding protein
HJD23_RS37070	COG4585	Histidine kinase
HJD23_RS37120	COG1063	alcohol dehydrogenase
HJD23_RS37140	COG1739	Uncharacterized protein family UPF0029
HJD23_RS37145	COG0420	3'-5' exonuclease activity
HJD23_RS37150	COG0419	ATPase involved in DNA repair
HJD23_RS37165	COG3135	benzoate transporter
HJD23_RS37170	COG1522	sequence-specific DNA binding
HJD23_RS37195	COG0626	cystathionine gamma-synthase activity
HJD23_RS37220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HJD23_RS37230	COG1595	DNA-templated transcription, initiation
HJD23_RS37235	COG2188	Transcriptional regulator
HJD23_RS37240	COG1940	carbohydrate kinase activity
HJD23_RS37245	COG2197	response regulator
HJD23_RS37250	COG4585	Histidine kinase
HJD23_RS37275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HJD23_RS37500	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HJD23_RS37715	COG1191	sigma factor activity
HJD23_RS37720	COG0028	Belongs to the TPP enzyme family
HJD23_RS37725	COG4948	Mandelate Racemase Muconate Lactonizing
HJD23_RS37730	COG0277	FAD linked oxidase domain protein
HJD23_RS37730	COG0247	lactate metabolic process
HJD23_RS37735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HJD23_RS37785	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HJD23_RS37795	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HJD23_RS37805	COG0713	ATP synthesis coupled electron transport
HJD23_RS37810	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HJD23_RS37820	COG1007	ATP synthesis coupled electron transport
HJD23_RS37825	COG0577	efflux transmembrane transporter activity
HJD23_RS37825	COG1136	(ABC) transporter
HJD23_RS37830	COG1136	(ABC) transporter
HJD23_RS37830	COG0577	efflux transmembrane transporter activity
HJD23_RS37845	COG2226	methyltransferase
HJD23_RS37850	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HJD23_RS37855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HJD23_RS37860	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HJD23_RS37885	COG0583	DNA-binding transcription factor activity
HJD23_RS37890	COG1280	lysine exporter protein (LysE YggA)
HJD23_RS37915	COG1309	transcriptional regulator
HJD23_RS37920	COG0831	urea catabolic process
HJD23_RS37925	COG0832	Belongs to the urease beta subunit family
HJD23_RS37930	COG0804	urea catabolic process
HJD23_RS37940	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HJD23_RS37945	COG0829	nickel cation binding
HJD23_RS37990	COG0640	Transcriptional regulator
HJD23_RS38010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HJD23_RS38015	COG1834	amidinotransferase
HJD23_RS38020	COG1522	sequence-specific DNA binding
HJD23_RS38025	COG3279	Response regulator of the LytR AlgR family
HJD23_RS38035	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HJD23_RS38040	COG3275	phosphorelay sensor kinase activity
HJD23_RS38055	COG0205	6-phosphofructokinase activity
HJD23_RS38060	COG3442	glutamine amidotransferase
HJD23_RS38070	COG0242	peptide deformylase activity
HJD23_RS38080	COG1960	acyl-CoA dehydrogenase activity
HJD23_RS38090	COG2124	cytochrome p450
HJD23_RS38095	COG3424	synthase
HJD23_RS38105	COG1012	belongs to the aldehyde dehydrogenase family
HJD23_RS38115	COG1793	dna ligase
HJD23_RS38135	COG1960	acyl-CoA dehydrogenase activity
HJD23_RS38140	COG1960	acyl-CoA dehydrogenase activity
HJD23_RS38160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HJD23_RS38190	COG0859	PFAM glycosyl transferase family 9
HJD23_RS38195	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HJD23_RS38195	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HJD23_RS38200	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HJD23_RS38205	COG0438	transferase activity, transferring glycosyl groups
HJD23_RS38215	COG0859	PFAM glycosyl transferase family 9
HJD23_RS38220	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HJD23_RS38230	COG2192	nodulation
HJD23_RS38245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HJD23_RS38260	COG1846	Transcriptional regulator
HJD23_RS38260	COG1940	carbohydrate kinase activity
HJD23_RS38350	COG2018	Roadblock/LC7 domain
HJD23_RS38360	COG1946	Acyl-CoA thioesterase
HJD23_RS38375	COG0254	rRNA binding
HJD23_RS38385	COG1132	(ABC) transporter
HJD23_RS38390	COG1132	(ABC) transporter
HJD23_RS38400	COG1301	dicarboxylic acid transport
HJD23_RS38410	COG1132	(ABC) transporter
HJD23_RS38420	COG2072	flavoprotein involved in K transport
HJD23_RS38430	COG1609	Transcriptional regulator
HJD23_RS38430	COG2207	Transcriptional regulator
HJD23_RS38445	COG2755	lipolytic protein G-D-S-L family
HJD23_RS38460	COG4209	transmembrane transport
HJD23_RS38465	COG0395	ABC-type sugar transport system, permease component
HJD23_RS38480	COG3509	depolymerase
HJD23_RS38515	COG3507	Belongs to the glycosyl hydrolase 43 family
HJD23_RS38530	COG1472	Belongs to the glycosyl hydrolase 3 family
HJD23_RS38535	COG3458	cephalosporin-C deacetylase activity
HJD23_RS38545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HJD23_RS38595	COG2124	cytochrome p450
HJD23_RS38615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HJD23_RS38655	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HJD23_RS38665	COG0174	glutamine synthetase
HJD23_RS38680	COG4689	acetoacetate decarboxylase
HJD23_RS38685	COG1012	belongs to the aldehyde dehydrogenase family
HJD23_RS38695	COG0179	Fumarylacetoacetate (FAA) hydrolase
HJD23_RS38700	COG1309	transcriptional regulator
HJD23_RS38710	COG1012	belongs to the aldehyde dehydrogenase family
HJD23_RS38715	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HJD23_RS38720	COG1846	Transcriptional regulator
HJD23_RS38730	COG2197	response regulator
HJD23_RS38780	COG1131	(ABC) transporter
HJD23_RS38800	COG1960	acyl-CoA dehydrogenase activity
HJD23_RS38815	COG3509	depolymerase
HJD23_RS38825	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HJD23_RS38830	COG1902	pentaerythritol trinitrate reductase activity
HJD23_RS38835	COG0640	Transcriptional regulator
HJD23_RS38840	COG2233	PERMEase
HJD23_RS38865	COG1309	transcriptional regulator
HJD23_RS38870	COG0546	phosphoglycolate phosphatase activity
HJD23_RS38875	COG0671	phosphoesterase, PA-phosphatase related
HJD23_RS38895	COG0667	Aldo Keto reductase
HJD23_RS38920	COG0584	glycerophosphoryl diester phosphodiesterase
HJD23_RS38950	COG0204	Acyl-transferase
HJD23_RS38970	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HJD23_RS39010	COG1660	Displays ATPase and GTPase activities
HJD23_RS39020	COG0747	negative chemotaxis
HJD23_RS39025	COG0601	transmembrane transport
HJD23_RS39035	COG4608	Belongs to the ABC transporter superfamily
HJD23_RS39040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HJD23_RS39045	COG0445	tRNA wobble uridine modification
HJD23_RS39055	COG4585	Histidine kinase
HJD23_RS39060	COG2197	response regulator
HJD23_RS39105	COG3387	PFAM Glycoside hydrolase 15-related
HJD23_RS39125	COG2813	Specifically methylates the guanine in position
HJD23_RS39135	COG1940	carbohydrate kinase activity
HJD23_RS39165	COG1136	(ABC) transporter
HJD23_RS39170	COG0577	efflux transmembrane transporter activity
HJD23_RS39195	COG1349	DNA-binding transcription factor activity
HJD23_RS39215	COG0633	Ferredoxin
HJD23_RS39215	COG3217	Mosc domain protein beta barrel domain protein
HJD23_RS39230	COG1215	transferase activity, transferring glycosyl groups
HJD23_RS39235	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HJD23_RS39260	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS39275	COG0531	amino acid
HJD23_RS39295	COG4948	Mandelate Racemase Muconate Lactonizing
HJD23_RS39305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HJD23_RS39325	COG0251	oxidation-reduction process
HJD23_RS39335	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS39350	COG3842	ATPase activity
HJD23_RS39365	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HJD23_RS39370	COG3608	succinylglutamate desuccinylase aspartoacylase
HJD23_RS39375	COG1012	belongs to the aldehyde dehydrogenase family
HJD23_RS39380	COG0667	Aldo Keto reductase
HJD23_RS39390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HJD23_RS39390	COG0723	plastoquinol--plastocyanin reductase activity
HJD23_RS39400	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS39415	COG1120	ATPase activity
HJD23_RS39430	COG0803	Belongs to the bacterial solute-binding protein 9 family
HJD23_RS39470	COG4977	sequence-specific DNA binding
HJD23_RS39510	COG2130	NADP-dependent
HJD23_RS39515	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS39525	COG0596	Alpha beta hydrolase
HJD23_RS39530	COG0183	Belongs to the thiolase family
HJD23_RS39535	COG1011	Hydrolase
HJD23_RS39540	COG1309	transcriptional regulator
HJD23_RS39545	COG1028	Short-chain dehydrogenase reductase Sdr
HJD23_RS39550	COG1024	Enoyl-CoA hydratase
HJD23_RS39555	COG1960	acyl-CoA dehydrogenase activity
HJD23_RS39605	COG3842	ATPase activity
HJD23_RS39610	COG3842	ATPase activity
HJD23_RS39615	COG0395	ABC-type sugar transport system, permease component
HJD23_RS39635	COG3284	Transcriptional regulator
HJD23_RS39640	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HJD23_RS39705	COG0517	IMP dehydrogenase activity
HJD23_RS39715	COG4109	DRTGG domain
HJD23_RS39725	COG0517	IMP dehydrogenase activity
HJD23_RS39740	COG2259	Doxx family
HJD23_RS39745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HJD23_RS39750	COG3842	ATPase activity
HJD23_RS39770	COG2188	Transcriptional regulator
HJD23_RS39775	COG0330	HflC and HflK could
HJD23_RS39820	COG2255	four-way junction helicase activity
HJD23_RS39840	COG1115	amino acid carrier protein
HJD23_RS39875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HJD23_RS39880	COG1121	(ABC) transporter
HJD23_RS39890	COG0803	Belongs to the bacterial solute-binding protein 9 family
HJD23_RS39910	COG0148	phosphopyruvate hydratase activity
HJD23_RS39920	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HJD23_RS39925	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HJD23_RS39930	COG2326	polyphosphate kinase activity
HJD23_RS39985	COG1309	transcriptional regulator
HJD23_RS40015	COG2197	response regulator
HJD23_RS40020	COG4585	Histidine kinase
HJD23_RS40030	COG1695	Transcriptional regulator
HJD23_RS40050	COG0492	ferredoxin-NADP+ reductase activity
HJD23_RS40055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HJD23_RS40060	COG0640	Transcriptional regulator
HJD23_RS40070	COG2072	flavoprotein involved in K transport
HJD23_RS40075	COG0640	Transcriptional regulator
HJD23_RS40095	COG1191	sigma factor activity
HJD23_RS40100	COG1396	sequence-specific DNA binding
HJD23_RS40105	COG0740	serine-type endopeptidase activity
HJD23_RS40110	COG0740	serine-type endopeptidase activity
HJD23_RS40115	COG0596	Alpha beta hydrolase
HJD23_RS40145	COG0328	RNA-DNA hybrid ribonuclease activity
HJD23_RS40170	COG2304	oxidoreductase activity
HJD23_RS40180	COG0667	Aldo Keto reductase
HJD23_RS40190	COG3647	Membrane
HJD23_RS40200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HJD23_RS40205	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HJD23_RS40205	COG0515	serine threonine protein kinase
HJD23_RS40260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HJD23_RS40275	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HJD23_RS40285	COG1120	ATPase activity
HJD23_RS40290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HJD23_RS40295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HJD23_RS40310	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HJD23_RS40315	COG1132	(ABC) transporter
HJD23_RS40330	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HJD23_RS40340	COG0673	inositol 2-dehydrogenase activity
HJD23_RS40345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HJD23_RS40350	COG0577	efflux transmembrane transporter activity
HJD23_RS40350	COG1136	(ABC) transporter
HJD23_RS40365	COG0318	PFAM AMP-dependent synthetase and ligase
HJD23_RS40370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HJD23_RS40395	COG0444	Belongs to the ABC transporter superfamily
HJD23_RS40400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HJD23_RS40405	COG0601	transmembrane transport
HJD23_RS40450	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HJD23_RS40475	COG0395	ABC-type sugar transport system, permease component
HJD23_RS40480	COG1175	transmembrane transport
HJD23_RS40485	COG1653	transport
HJD23_RS40500	COG0640	Transcriptional regulator
HJD23_RS40510	COG2186	Transcriptional regulator
HJD23_RS40515	COG1113	amino acid transport
HJD23_RS40530	COG2066	Belongs to the glutaminase family
HJD23_RS40540	COG1686	Belongs to the peptidase S11 family
HJD23_RS40545	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HJD23_RS40560	COG2188	Transcriptional regulator
HJD23_RS40575	COG3458	cephalosporin-C deacetylase activity
HJD23_RS40585	COG2890	protein-(glutamine-N5) methyltransferase activity
HJD23_RS40605	COG0446	pyridine nucleotide-disulphide oxidoreductase
HJD23_RS40605	COG1902	pentaerythritol trinitrate reductase activity
HJD23_RS40645	COG1461	Dihydroxyacetone kinase
HJD23_RS40650	COG2376	Dihydroxyacetone kinase
HJD23_RS40660	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HJD23_RS40680	COG0247	lactate metabolic process
HJD23_RS40680	COG0277	FAD linked oxidase domain protein
HJD23_RS40720	COG0437	4 iron, 4 sulfur cluster binding
HJD23_RS40725	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HJD23_RS40740	COG0375	protein maturation
HJD23_RS40765	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HJD23_RS40800	COG1755	Isoprenylcysteine carboxyl methyltransferase
HJD23_RS40810	COG3250	beta-galactosidase activity
HJD23_RS40825	COG2182	Extracellular solute-binding protein
HJD23_RS40850	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HJD23_RS40920	COG3250	beta-galactosidase activity
HJD23_RS40920	COG5297	Belongs to the glycosyl hydrolase family 6
HJD23_RS40925	COG0569	domain protein
HJD23_RS40925	COG0475	glutathione-regulated potassium exporter activity
HJD23_RS40935	COG0667	Aldo Keto reductase
HJD23_RS40950	COG1609	Transcriptional regulator
HJD23_RS41000	COG1960	acyl-CoA dehydrogenase activity
HJD23_RS41030	COG0514	ATP-dependent DNA helicase (RecQ)
HJD23_RS41055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HJD23_RS41055	COG1042	CoA-binding domain protein
HJD23_RS41055	COG0045	succinate-CoA ligase (ADP-forming) activity
HJD23_RS41080	COG0574	Belongs to the PEP-utilizing enzyme family
HJD23_RS41080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HJD23_RS41095	COG0589	response to stress
HJD23_RS41105	COG4651	solute:proton antiporter activity
HJD23_RS41105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HJD23_RS41115	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HJD23_RS41125	COG3842	ATPase activity
HJD23_RS41130	COG1178	ABC-type Fe3 transport system permease component
HJD23_RS41145	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HJD23_RS41195	COG0508	dehydrogenase complex catalyzes the overall conversion of
HJD23_RS41200	COG0508	dehydrogenase complex catalyzes the overall conversion of
HJD23_RS41200	COG0022	dehydrogenase e1 component
HJD23_RS41205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HJD23_RS41210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HJD23_RS41215	COG1063	alcohol dehydrogenase
HJD23_RS41255	COG0589	response to stress
HJD23_RS41270	COG0071	Belongs to the small heat shock protein (HSP20) family
HJD23_RS41290	COG0516	GMP reductase activity
HJD23_RS41290	COG0517	IMP dehydrogenase activity
HJD23_RS41305	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HJD23_RS41320	COG1140	nitrate reductase beta subunit
HJD23_RS41335	COG3383	formate dehydrogenase (NAD+) activity
HJD23_RS41370	COG3328	transposase activity
HJD23_RS41385	COG0515	serine threonine protein kinase
HJD23_RS41400	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HJD23_RS41405	COG2070	2-Nitropropane dioxygenase
HJD23_RS41420	COG0318	PFAM AMP-dependent synthetase and ligase
HJD23_RS41505	COG0673	inositol 2-dehydrogenase activity
HJD23_RS41570	COG1846	Transcriptional regulator
HJD23_RS41575	COG1796	DNA polymerase
HJD23_RS41575	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HJD23_RS41600	COG2080	2 iron, 2 sulfur cluster binding
HJD23_RS41620	COG0346	lactoylglutathione lyase activity
HJD23_RS41625	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HJD23_RS41635	COG0583	DNA-binding transcription factor activity
HJD23_RS41640	COG0667	Aldo Keto reductase
HJD23_RS41675	COG0842	Transport permease protein
HJD23_RS41675	COG1716	ATPase activity
HJD23_RS41675	COG1131	(ABC) transporter
HJD23_RS41690	COG2340	Cysteine-rich secretory protein family
HJD23_RS41725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HJD23_RS41750	COG3189	MarR family transcriptional regulator
HJD23_RS41775	COG0477	Major facilitator Superfamily
HJD23_RS41830	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HJD23_RS41835	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HJD23_RS41840	COG3281	Trehalose synthase
HJD23_RS41850	COG0366	Alpha amylase catalytic
HJD23_RS41895	COG0181	hydroxymethylbilane synthase activity
HJD23_RS41905	COG1793	dna ligase
HJD23_RS41910	COG2197	response regulator
HJD23_RS41915	COG1846	Transcriptional regulator
HJD23_RS41940	COG1609	Transcriptional regulator
HJD23_RS41950	COG0395	ABC-type sugar transport system, permease component
HJD23_RS41955	COG1175	transmembrane transport
HJD23_RS41965	COG1621	beta-fructofuranosidase activity
HJD23_RS41985	COG0009	L-threonylcarbamoyladenylate synthase
HJD23_RS41995	COG2124	cytochrome p450
HJD23_RS42035	COG3290	protein histidine kinase activity
HJD23_RS42055	COG2813	Specifically methylates the guanine in position
HJD23_RS42060	COG0723	plastoquinol--plastocyanin reductase activity
HJD23_RS42060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HJD23_RS42215	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HJD23_RS42235	COG2234	aminopeptidase activity
HJD23_RS42235	COG4935	Belongs to the peptidase S8 family
HJD23_RS42265	COG2124	cytochrome p450
HJD23_RS42280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HJD23_RS42295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HJD23_RS42305	COG0326	Molecular chaperone. Has ATPase activity
HJD23_RS42315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HJD23_RS42320	COG3250	beta-galactosidase activity
HJD23_RS42330	COG2423	ornithine cyclodeaminase activity
HJD23_RS42335	COG1309	transcriptional regulator
HJD23_RS42355	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HJD23_RS42370	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HJD23_RS42375	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HJD23_RS42380	COG1012	belongs to the aldehyde dehydrogenase family
HJD23_RS42385	COG0517	IMP dehydrogenase activity
HJD23_RS42385	COG4175	Glycine betaine
HJD23_RS42390	COG4176	ABC-type proline glycine betaine transport system permease component
HJD23_RS42405	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HJD23_RS42425	COG0438	transferase activity, transferring glycosyl groups
HJD23_RS42430	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HJD23_RS42435	COG1760	l-serine dehydratase
HJD23_RS42440	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HJD23_RS42460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HJD23_RS42485	COG1175	transmembrane transport
HJD23_RS42495	COG0454	-acetyltransferase
HJD23_RS42495	COG0456	acetyltransferase
HJD23_RS42565	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HJD23_RS42570	COG1404	Belongs to the peptidase S8 family
HJD23_RS42660	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HJD23_RS42680	COG3547	Transposase (IS116 IS110 IS902 family)
HJD23_RS42690	COG2801	Transposase and inactivated derivatives
HJD23_RS42720	COG2801	Transposase and inactivated derivatives
HJD23_RS42755	COG3903	Transcriptional regulator
HJD23_RS42755	COG2197	response regulator
HJD23_RS42800	COG0789	Transcriptional regulator
HJD23_RS42805	COG4221	oxidoreductase activity
HJD23_RS42825	COG2801	Transposase and inactivated derivatives