locus-tag	class	description
DN051_RS00010	COG0419	ATPase involved in DNA repair
DN051_RS00040	COG4942	peptidase
DN051_RS00160	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DN051_RS00510	COG3971	2-oxopent-4-enoate hydratase activity
DN051_RS00515	COG4569	acetaldehyde dehydrogenase (acetylating) activity
DN051_RS00650	COG0582	viral genome integration into host DNA
DN051_RS00710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DN051_RS00750	COG0667	Aldo Keto reductase
DN051_RS00755	COG2207	Transcriptional regulator
DN051_RS00760	COG2318	DinB family
DN051_RS00790	COG2801	Transposase and inactivated derivatives
DN051_RS00840	COG1404	Belongs to the peptidase S8 family
DN051_RS00860	COG0745	RESPONSE REGULATOR receiver
DN051_RS00865	COG2205	protein histidine kinase activity
DN051_RS00880	COG1136	(ABC) transporter
DN051_RS00880	COG0577	efflux transmembrane transporter activity
DN051_RS00885	COG0577	efflux transmembrane transporter activity
DN051_RS00895	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DN051_RS00905	COG1404	Belongs to the peptidase S8 family
DN051_RS00920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DN051_RS00940	COG2226	methyltransferase
DN051_RS00995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DN051_RS01035	COG4974	Belongs to the 'phage' integrase family
DN051_RS01045	COG4974	Belongs to the 'phage' integrase family
DN051_RS01085	COG0667	Aldo Keto reductase
DN051_RS01095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DN051_RS01200	COG0492	ferredoxin-NADP+ reductase activity
DN051_RS01210	COG4585	Histidine kinase
DN051_RS01215	COG2197	response regulator
DN051_RS01265	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DN051_RS01270	COG0366	Alpha amylase catalytic
DN051_RS01275	COG3119	arylsulfatase activity
DN051_RS01290	COG0395	ABC-type sugar transport system, permease component
DN051_RS01295	COG1175	transmembrane transport
DN051_RS01315	COG1132	(ABC) transporter
DN051_RS01320	COG1132	(ABC) transporter
DN051_RS01445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DN051_RS01515	COG0714	Associated with various cellular activities
DN051_RS01545	COG4249	Peptidase C14 caspase catalytic subunit p20
DN051_RS01545	COG2319	Wd-40 repeat
DN051_RS01650	COG0148	phosphopyruvate hydratase activity
DN051_RS01665	COG3265	gluconokinase activity
DN051_RS01670	COG3547	Transposase (IS116 IS110 IS902 family)
DN051_RS01680	COG3795	YCII-related domain
DN051_RS01685	COG4941	Belongs to the sigma-70 factor family
DN051_RS01725	COG0179	Fumarylacetoacetate (FAA) hydrolase
DN051_RS01750	COG0657	acetylesterase activity
DN051_RS01765	COG2072	flavoprotein involved in K transport
DN051_RS01775	COG0183	Belongs to the thiolase family
DN051_RS01780	COG1024	Enoyl-CoA hydratase
DN051_RS01785	COG1960	acyl-CoA dehydrogenase activity
DN051_RS01790	COG1960	acyl-CoA dehydrogenase activity
DN051_RS01830	COG2259	Doxx family
DN051_RS01870	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DN051_RS01895	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DN051_RS01910	COG0179	Fumarylacetoacetate (FAA) hydrolase
DN051_RS01935	COG1733	regulation of RNA biosynthetic process
DN051_RS01945	COG0477	Major facilitator Superfamily
DN051_RS01950	COG3344	reverse transcriptase
DN051_RS01975	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DN051_RS01985	COG2267	carboxylic ester hydrolase activity
DN051_RS01990	COG0584	glycerophosphoryl diester phosphodiesterase
DN051_RS02000	COG1316	TRANSCRIPTIONal
DN051_RS02010	COG1278	Cold shock
DN051_RS02040	COG1278	Cold shock
DN051_RS02050	COG0747	negative chemotaxis
DN051_RS02060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DN051_RS02080	COG1733	regulation of RNA biosynthetic process
DN051_RS02125	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DN051_RS02135	COG0747	negative chemotaxis
DN051_RS02140	COG0601	transmembrane transport
DN051_RS02145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DN051_RS02150	COG0444	Belongs to the ABC transporter superfamily
DN051_RS02155	COG4608	Belongs to the ABC transporter superfamily
DN051_RS02190	COG3424	synthase
DN051_RS02245	COG2135	peptidase activity
DN051_RS02265	COG0604	alcohol dehydrogenase
DN051_RS02275	COG0583	DNA-binding transcription factor activity
DN051_RS02280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DN051_RS02295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DN051_RS02305	COG2376	Dihydroxyacetone kinase
DN051_RS02310	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DN051_RS02345	COG0402	S-adenosylhomocysteine deaminase activity
DN051_RS02350	COG0583	DNA-binding transcription factor activity
DN051_RS02375	COG3265	gluconokinase activity
DN051_RS02380	COG1404	Belongs to the peptidase S8 family
DN051_RS02405	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DN051_RS02435	COG1191	sigma factor activity
DN051_RS02470	COG2197	response regulator
DN051_RS02475	COG4585	Histidine kinase
DN051_RS02490	COG2409	Drug exporters of the RND superfamily
DN051_RS02520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DN051_RS02555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DN051_RS02565	COG1595	DNA-templated transcription, initiation
DN051_RS02600	COG0667	Aldo Keto reductase
DN051_RS02605	COG2226	methyltransferase
DN051_RS02645	COG1175	transmembrane transport
DN051_RS02650	COG0395	ABC-type sugar transport system, permease component
DN051_RS02655	COG3250	beta-galactosidase activity
DN051_RS02660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DN051_RS02675	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DN051_RS02695	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DN051_RS02755	COG1120	ATPase activity
DN051_RS02760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN051_RS02765	COG4558	Periplasmic binding protein
DN051_RS02770	COG5398	heme oxygenase
DN051_RS02795	COG0569	domain protein
DN051_RS02795	COG0475	glutathione-regulated potassium exporter activity
DN051_RS02855	COG1191	sigma factor activity
DN051_RS02895	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DN051_RS02915	COG2197	response regulator
DN051_RS02925	COG1136	(ABC) transporter
DN051_RS02950	COG2409	Drug exporters of the RND superfamily
DN051_RS02970	COG0667	Aldo Keto reductase
DN051_RS03025	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DN051_RS03030	COG0494	nUDIX hydrolase
DN051_RS03050	COG0640	Transcriptional regulator
DN051_RS03105	COG1819	glycosyl
DN051_RS03125	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
DN051_RS03130	COG1082	Xylose isomerase domain protein TIM barrel
DN051_RS03135	COG1063	alcohol dehydrogenase
DN051_RS03150	COG0395	ABC-type sugar transport system, permease component
DN051_RS03165	COG0667	Aldo Keto reductase
DN051_RS03190	COG0745	RESPONSE REGULATOR receiver
DN051_RS03195	COG2205	protein histidine kinase activity
DN051_RS03220	COG0395	ABC-type sugar transport system, permease component
DN051_RS03225	COG1175	transmembrane transport
DN051_RS03245	COG1216	Glycosyl transferase, family 2
DN051_RS03250	COG0242	peptide deformylase activity
DN051_RS03275	COG2826	transposase and inactivated derivatives, IS30 family
DN051_RS03285	COG1172	Belongs to the binding-protein-dependent transport system permease family
DN051_RS03290	COG1172	Belongs to the binding-protein-dependent transport system permease family
DN051_RS03295	COG1129	ABC transporter
DN051_RS03300	COG1879	ABC-type sugar transport system periplasmic component
DN051_RS03305	COG1609	Transcriptional regulator
DN051_RS03355	COG2770	Histidine kinase
DN051_RS03355	COG2208	phosphoserine phosphatase activity
DN051_RS03375	COG1302	Protein conserved in bacteria
DN051_RS03395	COG0655	NAD(P)H dehydrogenase (quinone) activity
DN051_RS03400	COG1404	Belongs to the peptidase S8 family
DN051_RS03415	COG1649	PFAM Uncharacterised BCR, COG1649
DN051_RS03440	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DN051_RS03445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DN051_RS03495	COG0464	growth
DN051_RS03500	COG1404	Belongs to the peptidase S8 family
DN051_RS03505	COG1674	ftsk spoiiie
DN051_RS03525	COG4842	Belongs to the WXG100 family
DN051_RS03560	COG2084	Dehydrogenase
DN051_RS03595	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DN051_RS03600	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DN051_RS03610	COG2814	Major facilitator Superfamily
DN051_RS03620	COG1802	Transcriptional regulator
DN051_RS03630	COG0022	dehydrogenase e1 component
DN051_RS03635	COG0508	dehydrogenase complex catalyzes the overall conversion of
DN051_RS03640	COG3620	sequence-specific DNA binding
DN051_RS03650	COG0006	proline dipeptidase activity
DN051_RS03655	COG1335	isochorismatase
DN051_RS03700	COG3629	intracellular signal transduction
DN051_RS03700	COG3903	Transcriptional regulator
DN051_RS03795	COG1222	aaa ATPase
DN051_RS03805	COG2197	response regulator
DN051_RS03835	COG1012	belongs to the aldehyde dehydrogenase family
DN051_RS03845	COG1309	transcriptional regulator
DN051_RS03860	COG1070	Carbohydrate kinase
DN051_RS03870	COG1404	Belongs to the peptidase S8 family
DN051_RS03875	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS03880	COG1725	Transcriptional regulator
DN051_RS03905	COG1404	Belongs to the peptidase S8 family
DN051_RS03920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DN051_RS03925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DN051_RS03940	COG2175	clavaminate synthase activity
DN051_RS03950	COG0640	Transcriptional regulator
DN051_RS03960	COG0596	Alpha beta hydrolase
DN051_RS03970	COG1271	oxidase subunit
DN051_RS03980	COG0326	Molecular chaperone. Has ATPase activity
DN051_RS04015	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DN051_RS04020	COG0402	S-adenosylhomocysteine deaminase activity
DN051_RS04025	COG2814	Major facilitator Superfamily
DN051_RS04030	COG1414	Transcriptional regulator
DN051_RS04035	COG2255	four-way junction helicase activity
DN051_RS04055	COG0475	glutathione-regulated potassium exporter activity
DN051_RS04060	COG3537	Alpha-1,2-mannosidase
DN051_RS04070	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DN051_RS04080	COG1737	Transcriptional regulator
DN051_RS04085	COG0768	penicillin binding
DN051_RS04095	COG1309	transcriptional regulator
DN051_RS04110	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS04135	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DN051_RS04140	COG3250	beta-galactosidase activity
DN051_RS04170	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS04180	COG0300	oxidoreductase activity
DN051_RS04190	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DN051_RS04210	COG1819	glycosyl
DN051_RS04220	COG1609	Transcriptional regulator
DN051_RS04230	COG1175	transmembrane transport
DN051_RS04235	COG0395	ABC-type sugar transport system, permease component
DN051_RS04240	COG2723	6-phospho-beta-galactosidase activity
DN051_RS04245	COG1501	Belongs to the glycosyl hydrolase 31 family
DN051_RS04250	COG0477	Major facilitator Superfamily
DN051_RS04285	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
DN051_RS04325	COG0477	Major facilitator Superfamily
DN051_RS04345	COG1309	transcriptional regulator
DN051_RS04360	COG1846	Transcriptional regulator
DN051_RS04430	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DN051_RS04455	COG1846	Transcriptional regulator
DN051_RS04490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DN051_RS04500	COG2319	Wd-40 repeat
DN051_RS04500	COG3903	Transcriptional regulator
DN051_RS04510	COG1063	alcohol dehydrogenase
DN051_RS04515	COG0535	radical SAM domain protein
DN051_RS04525	COG1902	pentaerythritol trinitrate reductase activity
DN051_RS04530	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS04540	COG2326	polyphosphate kinase activity
DN051_RS04550	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DN051_RS04565	COG2197	response regulator
DN051_RS04570	COG4585	Histidine kinase
DN051_RS04595	COG0596	Alpha beta hydrolase
DN051_RS04605	COG1017	nitric oxide dioxygenase activity
DN051_RS04605	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DN051_RS04615	COG0702	epimerase
DN051_RS04620	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DN051_RS04625	COG0473	3-isopropylmalate dehydrogenase activity
DN051_RS04625	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DN051_RS04630	COG0492	ferredoxin-NADP+ reductase activity
DN051_RS04635	COG1595	DNA-templated transcription, initiation
DN051_RS04640	COG0604	alcohol dehydrogenase
DN051_RS04645	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DN051_RS04665	COG1024	Enoyl-CoA hydratase
DN051_RS04670	COG1819	glycosyl
DN051_RS04675	COG3973	AAA domain
DN051_RS04685	COG1609	Transcriptional regulator
DN051_RS04700	COG0395	ABC-type sugar transport system, permease component
DN051_RS04720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DN051_RS04740	COG2267	carboxylic ester hydrolase activity
DN051_RS04750	COG0583	DNA-binding transcription factor activity
DN051_RS04780	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DN051_RS04810	COG0596	Alpha beta hydrolase
DN051_RS04825	COG0395	ABC-type sugar transport system, permease component
DN051_RS04830	COG1175	transmembrane transport
DN051_RS04835	COG1653	transport
DN051_RS04840	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DN051_RS04845	COG2186	Transcriptional regulator
DN051_RS04870	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS04875	COG0583	DNA-binding transcription factor activity
DN051_RS04880	COG1309	transcriptional regulator
DN051_RS04890	COG0657	acetylesterase activity
DN051_RS04920	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS04940	COG0596	Alpha beta hydrolase
DN051_RS04960	COG0702	epimerase
DN051_RS04970	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS05005	COG0745	RESPONSE REGULATOR receiver
DN051_RS05060	COG2223	nitrite transmembrane transporter activity
DN051_RS05110	COG1012	belongs to the aldehyde dehydrogenase family
DN051_RS05115	COG1408	metallophosphoesterase
DN051_RS05190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DN051_RS05200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DN051_RS05205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DN051_RS05210	COG3739	integral membrane protein
DN051_RS05225	COG0702	epimerase
DN051_RS05235	COG4213	ABC transporter substrate-binding protein
DN051_RS05240	COG2208	phosphoserine phosphatase activity
DN051_RS05240	COG2770	Histidine kinase
DN051_RS05245	COG4213	ABC transporter substrate-binding protein
DN051_RS05255	COG4214	carbohydrate transport
DN051_RS05335	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DN051_RS05340	COG2124	cytochrome p450
DN051_RS05360	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DN051_RS05370	COG4935	Belongs to the peptidase S8 family
DN051_RS05370	COG2234	aminopeptidase activity
DN051_RS05380	COG1024	Enoyl-CoA hydratase
DN051_RS05380	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DN051_RS05390	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
DN051_RS05425	COG0375	protein maturation
DN051_RS05430	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DN051_RS05465	COG1929	Belongs to the glycerate kinase type-1 family
DN051_RS05475	COG0745	RESPONSE REGULATOR receiver
DN051_RS05480	COG2205	protein histidine kinase activity
DN051_RS05515	COG0784	Response regulator, receiver
DN051_RS05520	COG4251	negative regulation of phosphorylation
DN051_RS05550	COG3290	protein histidine kinase activity
DN051_RS05555	COG4565	transcriptional regulatory protein
DN051_RS05635	COG1132	(ABC) transporter
DN051_RS05660	COG0667	Aldo Keto reductase
DN051_RS05675	COG0559	Belongs to the binding-protein-dependent transport system permease family
DN051_RS05680	COG0411	ABC transporter
DN051_RS05685	COG0410	ABC transporter
DN051_RS05690	COG2508	Transcriptional regulator
DN051_RS05725	COG3340	Belongs to the peptidase S51 family
DN051_RS05795	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DN051_RS05800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DN051_RS05800	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DN051_RS05830	COG1846	Transcriptional regulator
DN051_RS05830	COG1940	carbohydrate kinase activity
DN051_RS05835	COG1175	transmembrane transport
DN051_RS05880	COG1937	Protein conserved in bacteria
DN051_RS05890	COG1132	(ABC) transporter
DN051_RS05905	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DN051_RS06005	COG0248	Ppx GppA phosphatase
DN051_RS06025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DN051_RS06045	COG3250	beta-galactosidase activity
DN051_RS06050	COG2208	phosphoserine phosphatase activity
DN051_RS06050	COG1366	Belongs to the anti-sigma-factor antagonist family
DN051_RS06050	COG2172	sigma factor antagonist activity
DN051_RS06075	COG0667	Aldo Keto reductase
DN051_RS06105	COG0435	Glutathione S-transferase
DN051_RS06120	COG2124	cytochrome p450
DN051_RS06185	COG1796	DNA polymerase
DN051_RS06185	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DN051_RS06210	COG2706	6-phosphogluconolactonase activity
DN051_RS06230	COG1609	Transcriptional regulator
DN051_RS06250	COG1172	Belongs to the binding-protein-dependent transport system permease family
DN051_RS06255	COG1129	ABC transporter
DN051_RS06265	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS06265	COG3347	Dehydrogenase
DN051_RS06270	COG1070	Carbohydrate kinase
DN051_RS06275	COG0247	lactate metabolic process
DN051_RS06280	COG1139	Iron-sulfur cluster binding protein
DN051_RS06285	COG1556	Lactate utilization protein
DN051_RS06290	COG1125	glycine betaine transport
DN051_RS06290	COG0517	IMP dehydrogenase activity
DN051_RS06305	COG1174	glycine betaine transport
DN051_RS06310	COG0577	efflux transmembrane transporter activity
DN051_RS06310	COG1136	(ABC) transporter
DN051_RS06325	COG0542	response to heat
DN051_RS06340	COG0604	alcohol dehydrogenase
DN051_RS06360	COG3486	L-lysine 6-monooxygenase (NADPH) activity
DN051_RS06370	COG1120	ATPase activity
DN051_RS06375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN051_RS06380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN051_RS06385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DN051_RS06395	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DN051_RS06400	COG1132	(ABC) transporter
DN051_RS06405	COG1132	(ABC) transporter
DN051_RS06415	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DN051_RS06445	COG0242	peptide deformylase activity
DN051_RS06455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DN051_RS06460	COG1609	Transcriptional regulator
DN051_RS06480	COG3629	intracellular signal transduction
DN051_RS06480	COG3903	Transcriptional regulator
DN051_RS06515	COG1131	(ABC) transporter
DN051_RS06565	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DN051_RS06570	COG0121	glutamine amidotransferase
DN051_RS06580	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
DN051_RS06790	COG2182	Extracellular solute-binding protein
DN051_RS06795	COG3360	Dodecin
DN051_RS06805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DN051_RS06825	COG0542	response to heat
DN051_RS06845	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DN051_RS06850	COG1053	succinate dehydrogenase
DN051_RS06860	COG0583	DNA-binding transcription factor activity
DN051_RS06900	COG0726	polysaccharide deacetylase
DN051_RS06910	COG0531	amino acid
DN051_RS06935	COG2770	Histidine kinase
DN051_RS06935	COG2208	phosphoserine phosphatase activity
DN051_RS06940	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DN051_RS06970	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS06975	COG4948	Mandelate Racemase Muconate Lactonizing
DN051_RS06980	COG1172	Belongs to the binding-protein-dependent transport system permease family
DN051_RS06985	COG1129	ABC transporter
DN051_RS06990	COG1879	ABC-type sugar transport system periplasmic component
DN051_RS06995	COG2186	Transcriptional regulator
DN051_RS07015	COG0395	ABC-type sugar transport system, permease component
DN051_RS07020	COG1175	transmembrane transport
DN051_RS07025	COG1653	transport
DN051_RS07030	COG1609	Transcriptional regulator
DN051_RS07065	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DN051_RS07070	COG0297	glycogen (starch) synthase activity
DN051_RS07090	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DN051_RS07105	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DN051_RS07120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DN051_RS07130	COG1205	dead DEAH box helicase
DN051_RS07130	COG1111	helicase
DN051_RS07135	COG0210	DNA helicase
DN051_RS07155	COG1324	tolerance protein
DN051_RS07185	COG3387	PFAM Glycoside hydrolase 15-related
DN051_RS07275	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DN051_RS07305	COG0494	nUDIX hydrolase
DN051_RS07330	COG0154	amidase activity
DN051_RS07470	COG1181	Belongs to the D-alanine--D-alanine ligase family
DN051_RS07755	COG0582	viral genome integration into host DNA
DN051_RS07780	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DN051_RS07815	COG0582	viral genome integration into host DNA
DN051_RS07835	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DN051_RS07840	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DN051_RS07855	COG1522	sequence-specific DNA binding
DN051_RS07860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DN051_RS07875	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DN051_RS07910	COG1819	glycosyl
DN051_RS07930	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DN051_RS07940	COG1595	DNA-templated transcription, initiation
DN051_RS07945	COG1764	response to oxidative stress
DN051_RS07955	COG1053	succinate dehydrogenase
DN051_RS07965	COG0657	acetylesterase activity
DN051_RS07970	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DN051_RS07980	COG1595	DNA-templated transcription, initiation
DN051_RS08005	COG1132	(ABC) transporter
DN051_RS08015	COG1024	Enoyl-CoA hydratase
DN051_RS08025	COG0668	transmembrane transport
DN051_RS08030	COG2838	Isocitrate dehydrogenase
DN051_RS08105	COG0673	inositol 2-dehydrogenase activity
DN051_RS08110	COG3548	integral membrane protein
DN051_RS08115	COG1609	Transcriptional regulator
DN051_RS08120	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS08125	COG0673	inositol 2-dehydrogenase activity
DN051_RS08130	COG0076	glutamate decarboxylase activity
DN051_RS08140	COG3903	Transcriptional regulator
DN051_RS08140	COG3629	intracellular signal transduction
DN051_RS08150	COG1309	transcriptional regulator
DN051_RS08160	COG0318	PFAM AMP-dependent synthetase and ligase
DN051_RS08170	COG3321	synthase
DN051_RS08170	COG0604	alcohol dehydrogenase
DN051_RS08175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DN051_RS08205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DN051_RS08210	COG0183	Belongs to the thiolase family
DN051_RS08250	COG2188	Transcriptional regulator
DN051_RS08255	COG0494	nUDIX hydrolase
DN051_RS08295	COG0183	Belongs to the thiolase family
DN051_RS08315	COG0515	serine threonine protein kinase
DN051_RS08315	COG2815	serine threonine protein kinase
DN051_RS08320	COG0561	phosphatase activity
DN051_RS08330	COG0174	glutamine synthetase
DN051_RS08400	COG0583	DNA-binding transcription factor activity
DN051_RS08405	COG0156	8-amino-7-oxononanoate synthase activity
DN051_RS08410	COG1063	alcohol dehydrogenase
DN051_RS08445	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DN051_RS08455	COG2755	lipolytic protein G-D-S-L family
DN051_RS08470	COG2365	Tyrosine phosphatase family
DN051_RS08490	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DN051_RS08495	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DN051_RS08510	COG1657	PFAM Prenyltransferase squalene oxidase
DN051_RS08520	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DN051_RS08530	COG1562	ergosterol biosynthetic process
DN051_RS08535	COG1388	LysM domain
DN051_RS08535	COG1134	teichoic acid transport
DN051_RS08580	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DN051_RS08590	COG1024	Enoyl-CoA hydratase
DN051_RS08595	COG2183	response to ionizing radiation
DN051_RS08620	COG2936	dipeptidyl-peptidase activity
DN051_RS08635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DN051_RS08650	COG1250	3-hydroxyacyl-CoA dehydrogenase
DN051_RS08650	COG1024	Enoyl-CoA hydratase
DN051_RS08655	COG0183	Belongs to the thiolase family
DN051_RS08660	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DN051_RS08670	COG3268	Saccharopine dehydrogenase
DN051_RS08675	COG1515	deoxyribonuclease V activity
DN051_RS08695	COG0488	(ABC) transporter
DN051_RS08705	COG1834	amidinotransferase
DN051_RS08750	COG1793	dna ligase
DN051_RS08760	COG1470	cell adhesion involved in biofilm formation
DN051_RS08785	COG3485	protocatechuate 3,4-dioxygenase
DN051_RS08790	COG3485	protocatechuate 3,4-dioxygenase
DN051_RS08795	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DN051_RS08800	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DN051_RS08815	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DN051_RS08840	COG3511	phospholipase C
DN051_RS08875	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DN051_RS08895	COG1486	melibiose metabolic process
DN051_RS08900	COG1349	DNA-binding transcription factor activity
DN051_RS08905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DN051_RS08915	COG1175	transmembrane transport
DN051_RS08920	COG0395	ABC-type sugar transport system, permease component
DN051_RS08925	COG3250	beta-galactosidase activity
DN051_RS08945	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DN051_RS08960	COG0166	Belongs to the GPI family
DN051_RS08965	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DN051_RS08970	COG0406	alpha-ribazole phosphatase activity
DN051_RS08980	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DN051_RS08980	COG1082	Xylose isomerase domain protein TIM barrel
DN051_RS08985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DN051_RS08995	COG0477	Major facilitator Superfamily
DN051_RS09020	COG0438	transferase activity, transferring glycosyl groups
DN051_RS09040	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DN051_RS09060	COG0438	transferase activity, transferring glycosyl groups
DN051_RS09075	COG1183	phosphatidylcholine synthase activity
DN051_RS09100	COG2723	6-phospho-beta-galactosidase activity
DN051_RS09105	COG0395	ABC-type sugar transport system, permease component
DN051_RS09110	COG1175	transmembrane transport
DN051_RS09115	COG2182	Extracellular solute-binding protein
DN051_RS09120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DN051_RS09135	COG0584	glycerophosphoryl diester phosphodiesterase
DN051_RS09145	COG1012	belongs to the aldehyde dehydrogenase family
DN051_RS09155	COG0045	succinate-CoA ligase (ADP-forming) activity
DN051_RS09165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DN051_RS09175	COG2223	nitrite transmembrane transporter activity
DN051_RS09195	COG0084	hydrolase, TatD family'
DN051_RS09230	COG0673	inositol 2-dehydrogenase activity
DN051_RS09240	COG1172	Belongs to the binding-protein-dependent transport system permease family
DN051_RS09245	COG1129	ABC transporter
DN051_RS09250	COG1940	carbohydrate kinase activity
DN051_RS09270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DN051_RS09290	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DN051_RS09295	COG3383	formate dehydrogenase (NAD+) activity
DN051_RS09300	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DN051_RS09310	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DN051_RS09345	COG0656	L-ascorbic acid biosynthetic process
DN051_RS09355	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DN051_RS09360	COG2154	pterin-4-alpha-carbinolamine dehydratase
DN051_RS09390	COG0443	Heat shock 70 kDa protein
DN051_RS09445	COG0517	IMP dehydrogenase activity
DN051_RS09445	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DN051_RS09455	COG0488	(ABC) transporter
DN051_RS09465	COG2226	methyltransferase
DN051_RS09505	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DN051_RS09540	COG1619	proteins homologs of microcin C7 resistance protein MccF
DN051_RS09550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DN051_RS09555	COG2362	D-Aminopeptidase
DN051_RS09565	COG1366	Belongs to the anti-sigma-factor antagonist family
DN051_RS09565	COG2172	sigma factor antagonist activity
DN051_RS09565	COG2208	phosphoserine phosphatase activity
DN051_RS09585	COG0596	Alpha beta hydrolase
DN051_RS09590	COG0456	acetyltransferase
DN051_RS09600	COG1250	3-hydroxyacyl-CoA dehydrogenase
DN051_RS09610	COG0604	alcohol dehydrogenase
DN051_RS09615	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DN051_RS09615	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DN051_RS09620	COG2301	Belongs to the HpcH HpaI aldolase family
DN051_RS09630	COG1960	acyl-CoA dehydrogenase activity
DN051_RS09635	COG0688	phosphatidylethanolamine metabolic process
DN051_RS09650	COG0667	Aldo Keto reductase
DN051_RS09655	COG1929	Belongs to the glycerate kinase type-1 family
DN051_RS09670	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DN051_RS09690	COG0640	Transcriptional regulator
DN051_RS09720	COG0483	inositol monophosphate 1-phosphatase activity
DN051_RS09730	COG0583	DNA-binding transcription factor activity
DN051_RS09735	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DN051_RS09780	COG1953	Uracil, thiamine, allantoin
DN051_RS09790	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DN051_RS09805	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DN051_RS09830	COG0542	response to heat
DN051_RS09835	COG0405	Gamma-glutamyltransferase
DN051_RS09850	COG1126	abc transporter atp-binding protein
DN051_RS09870	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DN051_RS09875	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DN051_RS09885	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DN051_RS09895	COG1940	carbohydrate kinase activity
DN051_RS09900	COG1129	ABC transporter
DN051_RS09915	COG2188	Transcriptional regulator
DN051_RS09920	COG0673	inositol 2-dehydrogenase activity
DN051_RS09930	COG2197	response regulator
DN051_RS09960	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS09965	COG4266	Belongs to the allantoicase family
DN051_RS09970	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DN051_RS09975	COG1414	Transcriptional regulator
DN051_RS09985	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DN051_RS09990	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DN051_RS10010	COG4264	IucA IucC family
DN051_RS10030	COG0436	Aminotransferase
DN051_RS10035	COG0406	alpha-ribazole phosphatase activity
DN051_RS10070	COG2351	hydroxyisourate hydrolase activity
DN051_RS10090	COG3622	Belongs to the hyi family
DN051_RS10095	COG2084	Dehydrogenase
DN051_RS10105	COG3960	tartronate-semialdehyde synthase activity
DN051_RS10115	COG0318	PFAM AMP-dependent synthetase and ligase
DN051_RS10135	COG0598	Magnesium transport protein CorA
DN051_RS10140	COG1404	Belongs to the peptidase S8 family
DN051_RS10180	COG2252	PERMEase
DN051_RS10185	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DN051_RS10200	COG3835	regulator
DN051_RS10210	COG1802	Transcriptional regulator
DN051_RS10240	COG0028	Belongs to the TPP enzyme family
DN051_RS10255	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DN051_RS10265	COG1162	GTPase activity
DN051_RS10280	COG0277	FAD linked oxidase domain protein
DN051_RS10325	COG2040	homocysteine
DN051_RS10360	COG1917	Cupin 2, conserved barrel domain protein
DN051_RS10360	COG4977	sequence-specific DNA binding
DN051_RS10375	COG1960	acyl-CoA dehydrogenase activity
DN051_RS10405	COG0175	sulfate reduction
DN051_RS10410	COG0529	Catalyzes the synthesis of activated sulfate
DN051_RS10430	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DN051_RS10435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DN051_RS10455	COG2409	Drug exporters of the RND superfamily
DN051_RS10475	COG1175	transmembrane transport
DN051_RS10565	COG1309	transcriptional regulator
DN051_RS10580	COG3321	synthase
DN051_RS10580	COG4221	oxidoreductase activity
DN051_RS10580	COG0604	alcohol dehydrogenase
DN051_RS10580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DN051_RS10585	COG1404	Belongs to the peptidase S8 family
DN051_RS10600	COG2018	Roadblock/LC7 domain
DN051_RS10615	COG1174	glycine betaine transport
DN051_RS10620	COG1174	glycine betaine transport
DN051_RS10645	COG0745	RESPONSE REGULATOR receiver
DN051_RS10650	COG2205	protein histidine kinase activity
DN051_RS10660	COG1968	undecaprenyl-diphosphatase activity
DN051_RS10665	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DN051_RS10670	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DN051_RS10730	COG3220	belongs to the UPF0276 family
DN051_RS10745	COG3253	May function as heme-dependent peroxidase
DN051_RS10760	COG0446	pyridine nucleotide-disulphide oxidoreductase
DN051_RS10775	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DN051_RS10790	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DN051_RS10795	COG0183	Belongs to the thiolase family
DN051_RS10800	COG1250	3-hydroxyacyl-CoA dehydrogenase
DN051_RS10800	COG1024	Enoyl-CoA hydratase
DN051_RS10840	COG0531	amino acid
DN051_RS10845	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DN051_RS10850	COG4214	carbohydrate transport
DN051_RS10860	COG4213	ABC transporter substrate-binding protein
DN051_RS10865	COG1940	carbohydrate kinase activity
DN051_RS10870	COG0395	ABC-type sugar transport system, permease component
DN051_RS10875	COG1175	transmembrane transport
DN051_RS10880	COG1653	transport
DN051_RS10890	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DN051_RS10905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DN051_RS10920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DN051_RS10925	COG0431	NADPH-dependent FMN reductase
DN051_RS10940	COG0745	RESPONSE REGULATOR receiver
DN051_RS10960	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DN051_RS10965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DN051_RS10980	COG1012	belongs to the aldehyde dehydrogenase family
DN051_RS11020	COG1024	Enoyl-CoA hydratase
DN051_RS11030	COG0531	amino acid
DN051_RS11035	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DN051_RS11040	COG2235	arginine
DN051_RS11045	COG0475	glutathione-regulated potassium exporter activity
DN051_RS11050	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DN051_RS11055	COG2890	protein-(glutamine-N5) methyltransferase activity
DN051_RS11095	COG1799	cell septum assembly
DN051_RS11120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DN051_RS11130	COG2764	glyoxalase bleomycin resistance protein dioxygenase
DN051_RS11135	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DN051_RS11150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DN051_RS11155	COG0531	amino acid
DN051_RS11160	COG0569	domain protein
DN051_RS11190	COG1136	(ABC) transporter
DN051_RS11200	COG0756	dUTP diphosphatase activity
DN051_RS11225	COG2205	protein histidine kinase activity
DN051_RS11230	COG0745	RESPONSE REGULATOR receiver
DN051_RS11240	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DN051_RS11275	COG1435	thymidine kinase activity
DN051_RS11300	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DN051_RS11305	COG1802	Transcriptional regulator
DN051_RS11320	COG0612	Peptidase, M16
DN051_RS11325	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DN051_RS11345	COG0372	Belongs to the citrate synthase family
DN051_RS11360	COG3290	protein histidine kinase activity
DN051_RS11365	COG4565	transcriptional regulatory protein
DN051_RS11370	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DN051_RS11380	COG0187	DNA topoisomerase II activity
DN051_RS11395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DN051_RS11400	COG1802	Transcriptional regulator
DN051_RS11440	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DN051_RS11460	COG0588	phosphoglycerate mutase activity
DN051_RS11475	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DN051_RS11480	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DN051_RS11485	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DN051_RS11510	COG0366	Alpha amylase catalytic
DN051_RS11515	COG0395	ABC-type sugar transport system, permease component
DN051_RS11520	COG1175	transmembrane transport
DN051_RS11550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DN051_RS11560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DN051_RS11565	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DN051_RS11575	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DN051_RS11595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DN051_RS11600	COG2197	response regulator
DN051_RS11630	COG2205	protein histidine kinase activity
DN051_RS11635	COG0745	RESPONSE REGULATOR receiver
DN051_RS11640	COG1126	abc transporter atp-binding protein
DN051_RS11645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DN051_RS11650	COG0765	amino acid transport
DN051_RS11655	COG0765	amino acid transport
DN051_RS11660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DN051_RS11670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DN051_RS11685	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DN051_RS11690	COG0628	permease
DN051_RS11715	COG2207	Transcriptional regulator
DN051_RS11715	COG1917	Cupin 2, conserved barrel domain protein
DN051_RS11720	COG1201	RNA secondary structure unwinding
DN051_RS11725	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DN051_RS11730	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS11740	COG0783	Belongs to the Dps family
DN051_RS11745	COG1396	sequence-specific DNA binding
DN051_RS11750	COG1546	Belongs to the CinA family
DN051_RS11750	COG1058	Belongs to the CinA family
DN051_RS11760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DN051_RS11770	COG1674	ftsk spoiiie
DN051_RS11780	COG3437	response regulator, receiver
DN051_RS11780	COG2205	protein histidine kinase activity
DN051_RS11780	COG3850	Histidine kinase
DN051_RS11780	COG4999	Histidine kinase
DN051_RS11790	COG2208	phosphoserine phosphatase activity
DN051_RS11790	COG2770	Histidine kinase
DN051_RS11825	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DN051_RS11830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DN051_RS11850	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DN051_RS11855	COG0612	Peptidase, M16
DN051_RS11860	COG1185	polyribonucleotide nucleotidyltransferase activity
DN051_RS11865	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DN051_RS11875	COG0455	bacterial-type flagellum organization
DN051_RS11890	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DN051_RS11895	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DN051_RS11905	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DN051_RS11920	COG0779	Required for maturation of 30S ribosomal subunits
DN051_RS11940	COG0442	prolyl-tRNA aminoacylation
DN051_RS11955	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DN051_RS11960	COG0750	zinc metalloprotease
DN051_RS11965	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DN051_RS11980	COG1012	belongs to the aldehyde dehydrogenase family
DN051_RS12015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DN051_RS12020	COG1177	transmembrane transport
DN051_RS12025	COG1176	ABC-type spermidine putrescine transport system, permease component I
DN051_RS12030	COG3842	ATPase activity
DN051_RS12055	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DN051_RS12060	COG0584	glycerophosphoryl diester phosphodiesterase
DN051_RS12075	COG1012	belongs to the aldehyde dehydrogenase family
DN051_RS12085	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DN051_RS12120	COG3842	ATPase activity
DN051_RS12125	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DN051_RS12135	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DN051_RS12160	COG0575	Belongs to the CDS family
DN051_RS12165	COG0233	cytoplasmic translational termination
DN051_RS12170	COG0528	UMP kinase activity
DN051_RS12175	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DN051_RS12180	COG0052	Belongs to the universal ribosomal protein uS2 family
DN051_RS12185	COG4942	peptidase
DN051_RS12195	COG1191	sigma factor activity
DN051_RS12210	COG0792	nuclease activity
DN051_RS12225	COG0681	Belongs to the peptidase S26 family
DN051_RS12230	COG0681	Belongs to the peptidase S26 family
DN051_RS12245	COG0335	large ribosomal subunit rRNA binding
DN051_RS12250	COG0336	Belongs to the RNA methyltransferase TrmD family
DN051_RS12255	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DN051_RS12260	COG1837	Belongs to the UPF0109 family
DN051_RS12265	COG0228	four-way junction DNA binding
DN051_RS12275	COG0442	prolyl-tRNA aminoacylation
DN051_RS12285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DN051_RS12295	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DN051_RS12330	COG0477	Major facilitator Superfamily
DN051_RS12335	COG1196	nuclear chromosome segregation
DN051_RS12345	COG1254	Belongs to the acylphosphatase family
DN051_RS12350	COG2340	Cysteine-rich secretory protein family
DN051_RS12355	COG1733	regulation of RNA biosynthetic process
DN051_RS12360	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DN051_RS12365	COG0571	ribonuclease III activity
DN051_RS12370	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DN051_RS12385	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DN051_RS12390	COG0742	ribosomal rna small subunit methyltransferase
DN051_RS12400	COG0326	Molecular chaperone. Has ATPase activity
DN051_RS12410	COG1461	Dihydroxyacetone kinase
DN051_RS12415	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DN051_RS12420	COG0351	phosphomethylpyrimidine kinase
DN051_RS12440	COG1181	Belongs to the D-alanine--D-alanine ligase family
DN051_RS12445	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DN051_RS12455	COG1920	GTP binding
DN051_RS12465	COG0776	regulation of translation
DN051_RS12475	COG0066	3-isopropylmalate dehydratase activity
DN051_RS12480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DN051_RS12485	COG1414	Transcriptional regulator
DN051_RS12525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DN051_RS12530	COG0179	Fumarylacetoacetate (FAA) hydrolase
DN051_RS12545	COG2018	Roadblock/LC7 domain
DN051_RS12565	COG2018	Roadblock/LC7 domain
DN051_RS12585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DN051_RS12590	COG0300	oxidoreductase activity
DN051_RS12595	COG1032	radical SAM domain protein
DN051_RS12600	COG0697	spore germination
DN051_RS12605	COG0438	transferase activity, transferring glycosyl groups
DN051_RS12625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DN051_RS12640	COG2957	Belongs to the agmatine deiminase family
DN051_RS12645	COG0804	urea catabolic process
DN051_RS12650	COG0831	urea catabolic process
DN051_RS12650	COG0832	Belongs to the urease beta subunit family
DN051_RS12655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DN051_RS12660	COG0473	3-isopropylmalate dehydrogenase activity
DN051_RS12680	COG1012	belongs to the aldehyde dehydrogenase family
DN051_RS12685	COG0506	proline dehydrogenase activity
DN051_RS12690	COG2508	Transcriptional regulator
DN051_RS12700	COG0477	Major facilitator Superfamily
DN051_RS12705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DN051_RS12710	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DN051_RS12715	COG0440	acetolactate synthase activity
DN051_RS12725	COG3300	MHYT domain
DN051_RS12725	COG5001	Diguanylate cyclase
DN051_RS12740	COG0667	Aldo Keto reductase
DN051_RS12745	COG2133	pyrroloquinoline quinone binding
DN051_RS12755	COG1672	PFAM Archaeal ATPase
DN051_RS12755	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DN051_RS12770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN051_RS12775	COG2409	Drug exporters of the RND superfamily
DN051_RS12785	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DN051_RS12795	COG0154	amidase activity
DN051_RS12800	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DN051_RS12810	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DN051_RS12820	COG4221	oxidoreductase activity
DN051_RS12825	COG1611	Belongs to the LOG family
DN051_RS12835	COG0482	sulfurtransferase activity
DN051_RS12840	COG3023	N-Acetylmuramoyl-L-alanine amidase
DN051_RS12865	COG2860	membrane
DN051_RS12870	COG4608	Belongs to the ABC transporter superfamily
DN051_RS12875	COG0444	Belongs to the ABC transporter superfamily
DN051_RS12890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DN051_RS12910	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DN051_RS12915	COG0509	glycine decarboxylation via glycine cleavage system
DN051_RS12920	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DN051_RS12925	COG1760	l-serine dehydratase
DN051_RS12930	COG3409	Peptidoglycan-binding domain 1 protein
DN051_RS12930	COG3757	hydrolase, family 25
DN051_RS12935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DN051_RS12970	COG1376	ErfK ybiS ycfS ynhG family protein
DN051_RS12980	COG1132	(ABC) transporter
DN051_RS12985	COG1132	(ABC) transporter
DN051_RS12990	COG1132	(ABC) transporter
DN051_RS12995	COG1132	(ABC) transporter
DN051_RS13010	COG0058	SHG alpha-glucan phosphorylase activity
DN051_RS13030	COG0366	Alpha amylase catalytic
DN051_RS13040	COG3281	Trehalose synthase
DN051_RS13045	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DN051_RS13070	COG3290	protein histidine kinase activity
DN051_RS13075	COG4565	transcriptional regulatory protein
DN051_RS13085	COG1175	transmembrane transport
DN051_RS13090	COG0395	ABC-type sugar transport system, permease component
DN051_RS13100	COG0205	6-phosphofructokinase activity
DN051_RS13105	COG0857	belongs to the CobB CobQ family
DN051_RS13105	COG0280	phosphate acetyltransferase
DN051_RS13110	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DN051_RS13150	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DN051_RS13150	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DN051_RS13165	COG1309	transcriptional regulator
DN051_RS13210	COG2205	protein histidine kinase activity
DN051_RS13230	COG0183	Belongs to the thiolase family
DN051_RS13250	COG1131	(ABC) transporter
DN051_RS13285	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
DN051_RS13300	COG1250	3-hydroxyacyl-CoA dehydrogenase
DN051_RS13315	COG4585	Histidine kinase
DN051_RS13320	COG2197	response regulator
DN051_RS13340	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DN051_RS13345	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DN051_RS13350	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DN051_RS13355	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DN051_RS13360	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DN051_RS13365	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DN051_RS13370	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DN051_RS13385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DN051_RS13390	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DN051_RS13395	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DN051_RS13405	COG2890	protein-(glutamine-N5) methyltransferase activity
DN051_RS13410	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DN051_RS13415	COG0254	rRNA binding
DN051_RS13430	COG0083	homoserine kinase activity
DN051_RS13435	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DN051_RS13440	COG0460	homoserine dehydrogenase
DN051_RS13445	COG0019	diaminopimelate decarboxylase activity
DN051_RS13450	COG0018	arginyl-trna synthetase
DN051_RS13515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DN051_RS13540	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DN051_RS13545	COG0602	queuosine metabolic process
DN051_RS13550	COG0720	synthase
DN051_RS13570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DN051_RS13595	COG0655	NAD(P)H dehydrogenase (quinone) activity
DN051_RS13630	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS13715	COG1695	Transcriptional regulator
DN051_RS13725	COG0475	glutathione-regulated potassium exporter activity
DN051_RS13780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DN051_RS13815	COG0367	asparagine synthase
DN051_RS13830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN051_RS13870	COG0310	cobalt ion transport
DN051_RS13875	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
DN051_RS13880	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DN051_RS13885	COG1122	ATPase activity
DN051_RS13895	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DN051_RS13900	COG3285	dna ligase
DN051_RS13900	COG1793	dna ligase
DN051_RS13920	COG2205	protein histidine kinase activity
DN051_RS13925	COG0772	Belongs to the SEDS family
DN051_RS13930	COG0768	penicillin binding
DN051_RS13955	COG0791	NLP P60 protein
DN051_RS13955	COG3883	PFAM NLP P60 protein
DN051_RS13995	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DN051_RS14005	COG0745	RESPONSE REGULATOR receiver
DN051_RS14010	COG2205	protein histidine kinase activity
DN051_RS14020	COG0508	dehydrogenase complex catalyzes the overall conversion of
DN051_RS14020	COG0567	Dehydrogenase, E1 component
DN051_RS14055	COG0604	alcohol dehydrogenase
DN051_RS14060	COG0281	malic enzyme
DN051_RS14080	COG1126	abc transporter atp-binding protein
DN051_RS14085	COG4106	trans-aconitate 2-methyltransferase activity
DN051_RS14110	COG4941	Belongs to the sigma-70 factor family
DN051_RS14135	COG0142	geranyltranstransferase activity
DN051_RS14140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DN051_RS14175	COG1597	lipid kinase activity
DN051_RS14195	COG0363	glucosamine-6-phosphate deaminase activity
DN051_RS14200	COG1472	Belongs to the glycosyl hydrolase 3 family
DN051_RS14205	COG0395	ABC-type sugar transport system, permease component
DN051_RS14210	COG1175	transmembrane transport
DN051_RS14215	COG2182	Extracellular solute-binding protein
DN051_RS14220	COG2188	Transcriptional regulator
DN051_RS14225	COG1966	Carbon starvation protein
DN051_RS14250	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DN051_RS14250	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DN051_RS14255	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DN051_RS14270	COG2124	cytochrome p450
DN051_RS14280	COG0242	peptide deformylase activity
DN051_RS14295	COG2199	diguanylate cyclase activity
DN051_RS14295	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DN051_RS14300	COG5662	AntiSigma factor
DN051_RS14305	COG1595	DNA-templated transcription, initiation
DN051_RS14315	COG2135	peptidase activity
DN051_RS14325	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DN051_RS14330	COG1162	GTPase activity
DN051_RS14345	COG0483	inositol monophosphate 1-phosphatase activity
DN051_RS14355	COG0753	catalase activity
DN051_RS14380	COG1615	UPF0182 protein
DN051_RS14390	COG3480	Lon protease (S16) C-terminal proteolytic domain
DN051_RS14440	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DN051_RS14480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DN051_RS14485	COG0210	DNA helicase
DN051_RS14580	COG0513	Belongs to the DEAD box helicase family
DN051_RS14590	COG1432	Conserved Protein
DN051_RS14600	COG2095	MarC family integral membrane protein
DN051_RS14620	COG0598	Magnesium transport protein CorA
DN051_RS14655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DN051_RS14660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DN051_RS14675	COG1595	DNA-templated transcription, initiation
DN051_RS14690	COG1024	Enoyl-CoA hydratase
DN051_RS14695	COG0519	Catalyzes the synthesis of GMP from XMP
DN051_RS14705	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DN051_RS14715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DN051_RS14765	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DN051_RS14780	COG4608	Belongs to the ABC transporter superfamily
DN051_RS14785	COG0444	Belongs to the ABC transporter superfamily
DN051_RS14790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DN051_RS14795	COG0601	transmembrane transport
DN051_RS14810	COG4608	Belongs to the ABC transporter superfamily
DN051_RS14815	COG0444	Belongs to the ABC transporter superfamily
DN051_RS14820	COG0601	transmembrane transport
DN051_RS14825	COG4166	transmembrane transport
DN051_RS14830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DN051_RS14835	COG1217	gtp-binding protein TYPA
DN051_RS14855	COG1053	succinate dehydrogenase
DN051_RS14860	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DN051_RS14915	COG1309	transcriptional regulator
DN051_RS14925	COG2124	cytochrome p450
DN051_RS14960	COG0012	GTP binding
DN051_RS14975	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DN051_RS14985	COG1570	exodeoxyribonuclease VII activity
DN051_RS14990	COG1722	exodeoxyribonuclease VII activity
DN051_RS14995	COG0778	Nitroreductase
DN051_RS15020	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DN051_RS15020	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DN051_RS15025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DN051_RS15040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DN051_RS15045	COG3938	Belongs to the proline racemase family
DN051_RS15055	COG0114	fumarate hydratase activity
DN051_RS15075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DN051_RS15095	COG1136	(ABC) transporter
DN051_RS15110	COG0450	alkyl hydroperoxide reductase
DN051_RS15115	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DN051_RS15130	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DN051_RS15135	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DN051_RS15160	COG1132	(ABC) transporter
DN051_RS15165	COG1309	transcriptional regulator
DN051_RS15220	COG2197	response regulator
DN051_RS15225	COG3920	Histidine kinase
DN051_RS15255	COG2894	cell division
DN051_RS15275	COG2814	Major facilitator Superfamily
DN051_RS15310	COG2610	gluconate transmembrane transporter activity
DN051_RS15320	COG1414	Transcriptional regulator
DN051_RS15335	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DN051_RS15340	COG0436	Aminotransferase
DN051_RS15370	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DN051_RS15380	COG1309	transcriptional regulator
DN051_RS15410	COG1331	Highly conserved protein containing a thioredoxin domain
DN051_RS15425	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DN051_RS15435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DN051_RS15450	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DN051_RS15455	COG2255	four-way junction helicase activity
DN051_RS15480	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DN051_RS15560	COG2186	Transcriptional regulator
DN051_RS15585	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DN051_RS15645	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DN051_RS15665	COG2197	response regulator
DN051_RS15670	COG0596	Alpha beta hydrolase
DN051_RS15700	COG1064	alcohol dehydrogenase
DN051_RS15720	COG1136	(ABC) transporter
DN051_RS15750	COG2986	histidine ammonia-lyase
DN051_RS15760	COG1024	Enoyl-CoA hydratase
DN051_RS15770	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DN051_RS15775	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DN051_RS15775	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DN051_RS15780	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DN051_RS15800	COG0424	maF-like protein
DN051_RS15810	COG4770	biotin carboxylase activity
DN051_RS15835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DN051_RS15850	COG1012	belongs to the aldehyde dehydrogenase family
DN051_RS15855	COG1012	belongs to the aldehyde dehydrogenase family
DN051_RS15870	COG1595	DNA-templated transcription, initiation
DN051_RS15875	COG0745	RESPONSE REGULATOR receiver
DN051_RS15880	COG2205	protein histidine kinase activity
DN051_RS15905	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DN051_RS15915	COG0583	DNA-binding transcription factor activity
DN051_RS15920	COG2814	Major facilitator Superfamily
DN051_RS15950	COG1079	Belongs to the binding-protein-dependent transport system permease family
DN051_RS15960	COG3845	ABC transporter
DN051_RS15965	COG1744	ABC transporter substrate-binding protein PnrA-like
DN051_RS15970	COG1744	ABC transporter substrate-binding protein PnrA-like
DN051_RS15975	COG1473	amidohydrolase
DN051_RS15975	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DN051_RS15990	COG2089	acid synthase
DN051_RS16005	COG1216	Glycosyl transferase, family 2
DN051_RS16030	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DN051_RS16045	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DN051_RS16045	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DN051_RS16105	COG2009	succinate dehydrogenase
DN051_RS16115	COG1053	succinate dehydrogenase
DN051_RS16145	COG2409	Drug exporters of the RND superfamily
DN051_RS16150	COG0745	RESPONSE REGULATOR receiver
DN051_RS16155	COG2205	protein histidine kinase activity
DN051_RS16165	COG1408	metallophosphoesterase
DN051_RS16170	COG1686	Belongs to the peptidase S11 family
DN051_RS16175	COG1295	ribonuclease BN
DN051_RS16190	COG0180	Tryptophanyl-tRNA synthetase
DN051_RS16210	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DN051_RS16215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DN051_RS16220	COG0754	glutathionylspermidine amidase activity
DN051_RS16240	COG4176	ABC-type proline glycine betaine transport system permease component
DN051_RS16245	COG4175	Glycine betaine
DN051_RS16245	COG0517	IMP dehydrogenase activity
DN051_RS16255	COG1012	belongs to the aldehyde dehydrogenase family
DN051_RS16285	COG0039	L-malate dehydrogenase activity
DN051_RS16300	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DN051_RS16315	COG0515	serine threonine protein kinase
DN051_RS16320	COG0138	bifunctional purine biosynthesis protein purh
DN051_RS16350	COG0045	succinate-CoA ligase (ADP-forming) activity
DN051_RS16360	COG3552	Protein containing von Willebrand factor type A (VWA) domain
DN051_RS16365	COG2425	protein containing a von Willebrand factor type A (vWA) domain
DN051_RS16370	COG0714	Associated with various cellular activities
DN051_RS16385	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DN051_RS16385	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DN051_RS16420	COG0791	NLP P60 protein
DN051_RS16425	COG2197	response regulator
DN051_RS16465	COG1129	ABC transporter
DN051_RS16470	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DN051_RS16470	COG0519	Catalyzes the synthesis of GMP from XMP
DN051_RS16490	COG1012	belongs to the aldehyde dehydrogenase family
DN051_RS16495	COG2815	serine threonine protein kinase
DN051_RS16495	COG0515	serine threonine protein kinase
DN051_RS16505	COG0515	serine threonine protein kinase
DN051_RS16510	COG0515	serine threonine protein kinase
DN051_RS16525	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DN051_RS16535	COG0516	GMP reductase activity
DN051_RS16545	COG1595	DNA-templated transcription, initiation
DN051_RS16565	COG0583	DNA-binding transcription factor activity
DN051_RS16575	COG4221	oxidoreductase activity
DN051_RS16585	COG0459	protein refolding
DN051_RS16590	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DN051_RS16595	COG0726	polysaccharide deacetylase
DN051_RS16600	COG0726	polysaccharide deacetylase
DN051_RS16610	COG4941	Belongs to the sigma-70 factor family
DN051_RS16625	COG1609	Transcriptional regulator
DN051_RS16630	COG1653	transport
DN051_RS16635	COG1175	transmembrane transport
DN051_RS16655	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DN051_RS16675	COG0802	atpase or kinase
DN051_RS16680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DN051_RS16685	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DN051_RS16695	COG0736	holo-[acyl-carrier-protein] synthase activity
DN051_RS16700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DN051_RS16705	COG1072	(Pantothenic acid kinase))
DN051_RS16715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DN051_RS16720	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DN051_RS16725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DN051_RS16740	COG0101	tRNA pseudouridine synthase activity
DN051_RS16745	COG0203	ribosomal protein L17
DN051_RS16750	COG0202	RNA polymerase activity
DN051_RS16755	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DN051_RS16760	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DN051_RS16765	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DN051_RS16770	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DN051_RS16780	COG0563	adenylate kinase activity
DN051_RS16790	COG0200	Binds to the 23S rRNA
DN051_RS16795	COG1841	ribosomal large subunit assembly
DN051_RS16800	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DN051_RS16805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DN051_RS16810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DN051_RS16815	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DN051_RS16825	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DN051_RS16830	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DN051_RS16835	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DN051_RS16840	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DN051_RS16845	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DN051_RS16850	COG0255	Belongs to the universal ribosomal protein uL29 family
DN051_RS16855	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DN051_RS16860	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DN051_RS16865	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DN051_RS16870	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DN051_RS16875	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DN051_RS16880	COG0089	rRNA binding
DN051_RS16885	COG0088	Forms part of the polypeptide exit tunnel
DN051_RS16890	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DN051_RS16895	COG0051	transcription antitermination factor activity, RNA binding
DN051_RS16900	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DN051_RS16900	COG2755	lipolytic protein G-D-S-L family
DN051_RS16905	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DN051_RS16910	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DN051_RS16915	COG0049	tRNA binding
DN051_RS16920	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DN051_RS16965	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DN051_RS16970	COG0085	RNA polymerase activity
DN051_RS16980	COG0222	ribosome binding
DN051_RS16995	COG0081	regulation of translation
DN051_RS17000	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DN051_RS17010	COG0250	Participates in transcription elongation, termination and antitermination
DN051_RS17025	COG0436	Aminotransferase
DN051_RS17030	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DN051_RS17035	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DN051_RS17045	COG2030	dehydratase
DN051_RS17050	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DN051_RS17070	COG0702	epimerase
DN051_RS17095	COG1666	GTP binding
DN051_RS17100	COG2261	transglycosylase associated protein
DN051_RS17115	COG0501	Belongs to the peptidase M48B family
DN051_RS17120	COG1007	ATP synthesis coupled electron transport
DN051_RS17130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DN051_RS17135	COG0713	ATP synthesis coupled electron transport
DN051_RS17140	COG0839	Belongs to the complex I subunit 6 family
DN051_RS17145	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DN051_RS17150	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DN051_RS17155	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DN051_RS17160	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DN051_RS17165	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DN051_RS17170	COG4585	Histidine kinase
DN051_RS17185	COG0674	pyruvate-flavodoxin oxidoreductase activity
DN051_RS17185	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DN051_RS17190	COG1013	pyruvate-flavodoxin oxidoreductase activity
DN051_RS17195	COG1733	regulation of RNA biosynthetic process
DN051_RS17200	COG0702	epimerase
DN051_RS17240	COG1131	(ABC) transporter
DN051_RS17255	COG0142	geranyltranstransferase activity
DN051_RS17265	COG0561	phosphatase activity
DN051_RS17285	COG0514	ATP-dependent DNA helicase (RecQ)
DN051_RS17290	COG1007	ATP synthesis coupled electron transport
DN051_RS17300	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DN051_RS17305	COG0713	ATP synthesis coupled electron transport
DN051_RS17310	COG0839	Belongs to the complex I subunit 6 family
DN051_RS17315	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DN051_RS17320	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DN051_RS17325	COG1034	ATP synthesis coupled electron transport
DN051_RS17330	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DN051_RS17340	COG0649	NAD binding
DN051_RS17345	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DN051_RS17350	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DN051_RS17380	COG2226	methyltransferase
DN051_RS17390	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DN051_RS17470	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
DN051_RS17525	COG1674	ftsk spoiiie
DN051_RS17535	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DN051_RS17540	COG1278	Cold shock
DN051_RS17560	COG1309	transcriptional regulator
DN051_RS17580	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DN051_RS17590	COG0163	prenyltransferase activity
DN051_RS17600	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DN051_RS17615	COG0745	RESPONSE REGULATOR receiver
DN051_RS17645	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DN051_RS17650	COG1333	cytochrome c biogenesis protein
DN051_RS17655	COG0785	Cytochrome C biogenesis protein
DN051_RS17660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DN051_RS17670	COG0406	alpha-ribazole phosphatase activity
DN051_RS17675	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DN051_RS17695	COG0745	RESPONSE REGULATOR receiver
DN051_RS17705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DN051_RS17715	COG1742	UPF0060 membrane protein
DN051_RS17725	COG1690	Belongs to the RtcB family
DN051_RS17745	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DN051_RS17750	COG0018	arginyl-trna synthetase
DN051_RS17780	COG0113	porphobilinogen synthase activity
DN051_RS17785	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DN051_RS17785	COG1648	precorrin-2 dehydrogenase activity
DN051_RS17790	COG0181	hydroxymethylbilane synthase activity
DN051_RS17795	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DN051_RS17800	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DN051_RS17850	COG0123	including yeast histone deacetylase and acetoin utilization protein
DN051_RS17885	COG0180	Tryptophanyl-tRNA synthetase
DN051_RS17890	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DN051_RS17900	COG0842	Transport permease protein
DN051_RS17900	COG1129	ABC transporter
DN051_RS17915	COG4991	sh3 domain protein
DN051_RS17920	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DN051_RS17920	COG0515	serine threonine protein kinase
DN051_RS17925	COG0129	dihydroxy-acid dehydratase activity
DN051_RS17935	COG1082	Xylose isomerase domain protein TIM barrel
DN051_RS17940	COG0248	Ppx GppA phosphatase
DN051_RS17960	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DN051_RS17970	COG1194	a g-specific adenine glycosylase
DN051_RS17975	COG1595	DNA-templated transcription, initiation
DN051_RS17985	COG0745	RESPONSE REGULATOR receiver
DN051_RS17990	COG2205	protein histidine kinase activity
DN051_RS18005	COG0739	heme binding
DN051_RS18040	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DN051_RS18060	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DN051_RS18070	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DN051_RS18075	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DN051_RS18095	COG1660	Displays ATPase and GTPase activities
DN051_RS18100	COG2197	response regulator
DN051_RS18115	COG0649	NAD binding
DN051_RS18150	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DN051_RS18165	COG0302	gtp cyclohydrolase
DN051_RS18180	COG0037	tRNA processing
DN051_RS18190	COG2027	D-alanyl-D-alanine carboxypeptidase
DN051_RS18195	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DN051_RS18220	COG0789	Transcriptional regulator
DN051_RS18245	COG2318	DinB family
DN051_RS18250	COG1012	belongs to the aldehyde dehydrogenase family
DN051_RS18275	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DN051_RS18285	COG0254	rRNA binding
DN051_RS18290	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DN051_RS18295	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DN051_RS18300	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DN051_RS18325	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DN051_RS18325	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DN051_RS18330	COG3903	Transcriptional regulator
DN051_RS18330	COG3629	intracellular signal transduction
DN051_RS18335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DN051_RS18350	COG1136	(ABC) transporter
DN051_RS18350	COG0577	efflux transmembrane transporter activity
DN051_RS18355	COG0577	efflux transmembrane transporter activity
DN051_RS18360	COG1595	DNA-templated transcription, initiation
DN051_RS18390	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DN051_RS18395	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DN051_RS18400	COG1754	DNA topoisomerase type I activity
DN051_RS18400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DN051_RS18425	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DN051_RS18430	COG2172	sigma factor antagonist activity
DN051_RS18435	COG1366	Belongs to the anti-sigma-factor antagonist family
DN051_RS18440	COG1205	dead DEAH box helicase
DN051_RS18440	COG1111	helicase
DN051_RS18545	COG0659	secondary active sulfate transmembrane transporter activity
DN051_RS18550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DN051_RS18555	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DN051_RS18565	COG0596	Alpha beta hydrolase
DN051_RS18600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN051_RS18625	COG0003	Pfam Anion-transporting ATPase
DN051_RS18640	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DN051_RS18650	COG1408	metallophosphoesterase
DN051_RS18685	COG0492	ferredoxin-NADP+ reductase activity
DN051_RS18735	COG0701	Predicted permease
DN051_RS18740	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DN051_RS18740	COG4651	solute:proton antiporter activity
DN051_RS18765	COG1595	DNA-templated transcription, initiation
DN051_RS18795	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DN051_RS18800	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DN051_RS18810	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DN051_RS18825	COG0693	protein deglycase activity
DN051_RS18830	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DN051_RS18845	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DN051_RS18860	COG1131	(ABC) transporter
DN051_RS18865	COG3559	Exporter of polyketide antibiotics
DN051_RS18870	COG2124	cytochrome p450
DN051_RS18875	COG2197	response regulator
DN051_RS18880	COG4585	Histidine kinase
DN051_RS18885	COG2197	response regulator
DN051_RS18890	COG4585	Histidine kinase
DN051_RS18915	COG3844	kynureninase activity
DN051_RS18930	COG0477	Major facilitator Superfamily
DN051_RS18935	COG0191	fructose-bisphosphate aldolase activity
DN051_RS18940	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DN051_RS18955	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DN051_RS18980	COG0542	response to heat
DN051_RS19010	COG4213	ABC transporter substrate-binding protein
DN051_RS19020	COG0789	Transcriptional regulator
DN051_RS19025	COG0484	heat shock protein binding
DN051_RS19030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DN051_RS19035	COG0443	Heat shock 70 kDa protein
DN051_RS19040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DN051_RS19045	COG0247	lactate metabolic process
DN051_RS19045	COG2181	nitrate reductase activity
DN051_RS19075	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DN051_RS19080	COG0717	Belongs to the dCTP deaminase family
DN051_RS19090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN051_RS19120	COG1252	NADH dehydrogenase
DN051_RS19125	COG1595	DNA-templated transcription, initiation
DN051_RS19130	COG2132	Multicopper oxidase
DN051_RS19135	COG4335	DNA alkylation repair
DN051_RS19155	COG0601	transmembrane transport
DN051_RS19160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DN051_RS19165	COG0444	Belongs to the ABC transporter superfamily
DN051_RS19225	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DN051_RS19230	COG0366	Alpha amylase catalytic
DN051_RS19235	COG1957	nucleoside hydrolase
DN051_RS19240	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DN051_RS19305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN051_RS19315	COG1289	transmembrane transporter activity
DN051_RS19330	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DN051_RS19365	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DN051_RS19380	COG1741	Belongs to the pirin family
DN051_RS19395	COG1960	acyl-CoA dehydrogenase activity
DN051_RS19400	COG1362	aminopeptidase activity
DN051_RS19450	COG0508	dehydrogenase complex catalyzes the overall conversion of
DN051_RS19455	COG0022	dehydrogenase e1 component
DN051_RS19470	COG0515	serine threonine protein kinase
DN051_RS19475	COG0515	serine threonine protein kinase
DN051_RS19490	COG3321	synthase
DN051_RS19490	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS19490	COG0604	alcohol dehydrogenase
DN051_RS19510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DN051_RS19540	COG1522	sequence-specific DNA binding
DN051_RS19545	COG1309	transcriptional regulator
DN051_RS19550	COG1250	3-hydroxyacyl-CoA dehydrogenase
DN051_RS19575	COG3396	Phenylacetate-CoA oxygenase
DN051_RS19580	COG3460	Phenylacetate-CoA oxygenase
DN051_RS19585	COG3396	Phenylacetate-CoA oxygenase
DN051_RS19590	COG2151	metal-sulfur cluster biosynthetic enzyme
DN051_RS19595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DN051_RS19625	COG1716	ATPase activity
DN051_RS19630	COG1716	ATPase activity
DN051_RS19645	COG0768	penicillin binding
DN051_RS19655	COG0515	serine threonine protein kinase
DN051_RS19660	COG3764	Sortase (surface protein transpeptidase)
DN051_RS19665	COG3764	Sortase (surface protein transpeptidase)
DN051_RS19680	COG3764	Sortase (surface protein transpeptidase)
DN051_RS19695	COG0705	Rhomboid family
DN051_RS19720	COG0515	serine threonine protein kinase
DN051_RS19750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DN051_RS19755	COG0187	DNA topoisomerase II activity
DN051_RS19760	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
DN051_RS19765	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DN051_RS19770	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DN051_RS19775	COG0592	DNA-directed DNA polymerase activity
DN051_RS19785	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DN051_RS19790	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DN051_RS19795	COG0594	ribonuclease P activity
DN051_RS19800	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DN051_RS19805	COG0706	membrane insertase activity
DN051_RS19815	COG0357	Ribosomal RNA small subunit methyltransferase G
DN051_RS19820	COG1192	Involved in chromosome partitioning
DN051_RS19835	COG3118	belongs to the thioredoxin family
DN051_RS19840	COG0492	ferredoxin-NADP+ reductase activity
DN051_RS19850	COG1595	DNA-templated transcription, initiation
DN051_RS19855	COG0515	serine threonine protein kinase
DN051_RS19855	COG2815	serine threonine protein kinase
DN051_RS19870	COG0617	tRNA 3'-terminal CCA addition
DN051_RS19895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DN051_RS19920	COG0360	Binds together with S18 to 16S ribosomal RNA
DN051_RS19925	COG0629	single-stranded DNA binding
DN051_RS19930	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DN051_RS19935	COG0359	binds to the 23S rRNA
DN051_RS19945	COG0305	Participates in initiation and elongation during chromosome replication
DN051_RS19965	COG2814	Major facilitator Superfamily
DN051_RS19995	COG0626	cystathionine gamma-synthase activity
DN051_RS20000	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DN051_RS20005	COG1950	PFAM Membrane protein of
DN051_RS20010	COG0662	Cupin 2, conserved barrel domain protein
DN051_RS20035	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DN051_RS20055	COG1609	Transcriptional regulator
DN051_RS20060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DN051_RS20065	COG1271	oxidase subunit
DN051_RS20070	COG1294	oxidase, subunit
DN051_RS20075	COG4988	ABC transporter
DN051_RS20080	COG0739	heme binding
DN051_RS20080	COG0741	lytic transglycosylase activity
DN051_RS20080	COG1196	nuclear chromosome segregation
DN051_RS20085	COG0561	phosphatase activity
DN051_RS20100	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
DN051_RS20105	COG0789	Transcriptional regulator
DN051_RS20150	COG0561	phosphatase activity
DN051_RS20155	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DN051_RS20165	COG2837	iron assimilation
DN051_RS20180	COG1999	signal sequence binding
DN051_RS20200	COG0006	proline dipeptidase activity
DN051_RS20220	COG0653	protein targeting
DN051_RS20235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DN051_RS20250	COG2188	Transcriptional regulator
DN051_RS20310	COG1595	DNA-templated transcription, initiation
DN051_RS20315	COG0318	PFAM AMP-dependent synthetase and ligase
DN051_RS20320	COG0784	Response regulator, receiver
DN051_RS20355	COG0745	RESPONSE REGULATOR receiver
DN051_RS20360	COG3467	pyridoxamine 5'-phosphate
DN051_RS20380	COG2353	YceI-like domain
DN051_RS20385	COG0477	Major facilitator Superfamily
DN051_RS20405	COG1191	sigma factor activity
DN051_RS20410	COG1191	sigma factor activity
DN051_RS20445	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DN051_RS20510	COG1653	transport
DN051_RS20515	COG1175	transmembrane transport
DN051_RS20520	COG0395	ABC-type sugar transport system, permease component
DN051_RS20525	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DN051_RS20525	COG0515	serine threonine protein kinase
DN051_RS20575	COG2188	Transcriptional regulator
DN051_RS20720	COG0151	Belongs to the GarS family
DN051_RS20735	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DN051_RS20745	COG2197	response regulator
DN051_RS20750	COG3851	Histidine kinase
DN051_RS20780	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DN051_RS20785	COG0047	phosphoribosylformylglycinamidine synthase activity
DN051_RS20790	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DN051_RS20820	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DN051_RS20855	COG1643	Atp-dependent helicase
DN051_RS20890	COG0513	Belongs to the DEAD box helicase family
DN051_RS20905	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DN051_RS20905	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DN051_RS20915	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DN051_RS20940	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DN051_RS20945	COG0579	oxidoreductase
DN051_RS20970	COG1252	NADH dehydrogenase
DN051_RS21055	COG1196	nuclear chromosome segregation
DN051_RS21055	COG0739	heme binding
DN051_RS21055	COG0741	lytic transglycosylase activity
DN051_RS21060	COG0671	phosphoesterase, PA-phosphatase related
DN051_RS21065	COG0277	FAD linked oxidase domain protein
DN051_RS21085	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DN051_RS21090	COG0306	phosphate transporter
DN051_RS21100	COG1937	Protein conserved in bacteria
DN051_RS21115	COG0494	nUDIX hydrolase
DN051_RS21115	COG0406	alpha-ribazole phosphatase activity
DN051_RS21125	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DN051_RS21155	COG0456	acetyltransferase
DN051_RS21160	COG0737	Belongs to the 5'-nucleotidase family
DN051_RS21170	COG2205	protein histidine kinase activity
DN051_RS21175	COG0745	RESPONSE REGULATOR receiver
DN051_RS21180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DN051_RS21185	COG1609	Transcriptional regulator
DN051_RS21190	COG0745	RESPONSE REGULATOR receiver
DN051_RS21215	COG2897	thiosulfate sulfurtransferase activity
DN051_RS21260	COG3485	protocatechuate 3,4-dioxygenase
DN051_RS21265	COG0735	belongs to the Fur family
DN051_RS21270	COG0354	folic acid binding
DN051_RS21275	COG1490	D-aminoacyl-tRNA deacylase activity
DN051_RS21285	COG4552	Acetyltransferase involved in intracellular survival and related
DN051_RS21295	COG2188	Transcriptional regulator
DN051_RS21305	COG2188	Transcriptional regulator
DN051_RS21325	COG0546	phosphoglycolate phosphatase activity
DN051_RS21355	COG1733	regulation of RNA biosynthetic process
DN051_RS21395	COG0438	transferase activity, transferring glycosyl groups
DN051_RS21425	COG0588	phosphoglycerate mutase activity
DN051_RS21460	COG5002	protein histidine kinase activity
DN051_RS21480	COG1329	Transcriptional regulator
DN051_RS21490	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DN051_RS21495	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DN051_RS21500	COG0215	cysteine-tRNA ligase activity
DN051_RS21505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DN051_RS21525	COG3842	ATPase activity
DN051_RS21540	COG3629	intracellular signal transduction
DN051_RS21540	COG3903	Transcriptional regulator
DN051_RS21575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DN051_RS21575	COG0723	plastoquinol--plastocyanin reductase activity
DN051_RS21635	COG5001	Diguanylate cyclase
DN051_RS21635	COG3300	MHYT domain
DN051_RS21680	COG0463	Glycosyl transferase, family 2
DN051_RS21695	COG1278	Cold shock
DN051_RS21700	COG0459	protein refolding
DN051_RS21710	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS21735	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DN051_RS21740	COG1737	Transcriptional regulator
DN051_RS21775	COG3973	AAA domain
DN051_RS21785	COG1061	Type III restriction enzyme res subunit
DN051_RS21825	COG1278	Cold shock
DN051_RS21830	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DN051_RS21835	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DN051_RS21845	COG2814	Major facilitator Superfamily
DN051_RS21880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DN051_RS21890	COG2252	PERMEase
DN051_RS21915	COG0667	Aldo Keto reductase
DN051_RS21945	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DN051_RS21950	COG0247	lactate metabolic process
DN051_RS21950	COG0277	FAD linked oxidase domain protein
DN051_RS21990	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DN051_RS22005	COG0318	PFAM AMP-dependent synthetase and ligase
DN051_RS22015	COG1309	transcriptional regulator
DN051_RS22020	COG0259	pyridoxamine-phosphate oxidase activity
DN051_RS22040	COG4821	SIS domain
DN051_RS22050	COG2945	thiolester hydrolase activity
DN051_RS22050	COG0596	Alpha beta hydrolase
DN051_RS22105	COG1366	Belongs to the anti-sigma-factor antagonist family
DN051_RS22115	COG0318	PFAM AMP-dependent synthetase and ligase
DN051_RS22125	COG1960	acyl-CoA dehydrogenase activity
DN051_RS22130	COG1960	acyl-CoA dehydrogenase activity
DN051_RS22150	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS22155	COG1960	acyl-CoA dehydrogenase activity
DN051_RS22175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DN051_RS22180	COG1024	Enoyl-CoA hydratase
DN051_RS22190	COG2072	flavoprotein involved in K transport
DN051_RS22210	COG0259	pyridoxamine-phosphate oxidase activity
DN051_RS22225	COG1960	acyl-CoA dehydrogenase activity
DN051_RS22235	COG1280	lysine exporter protein (LysE YggA)
DN051_RS22245	COG1309	transcriptional regulator
DN051_RS22255	COG0515	serine threonine protein kinase
DN051_RS22255	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DN051_RS22260	COG1024	Enoyl-CoA hydratase
DN051_RS22275	COG0318	PFAM AMP-dependent synthetase and ligase
DN051_RS22315	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DN051_RS22320	COG1012	belongs to the aldehyde dehydrogenase family
DN051_RS22345	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DN051_RS22385	COG1686	Belongs to the peptidase S11 family
DN051_RS22410	COG0386	Belongs to the glutathione peroxidase family
DN051_RS22425	COG0475	glutathione-regulated potassium exporter activity
DN051_RS22430	COG2197	response regulator
DN051_RS22490	COG1136	(ABC) transporter
DN051_RS22515	COG0745	RESPONSE REGULATOR receiver
DN051_RS22520	COG2205	protein histidine kinase activity
DN051_RS22530	COG1414	Transcriptional regulator
DN051_RS22555	COG3384	dioxygenase
DN051_RS22560	COG1247	-acetyltransferase
DN051_RS22580	COG1349	DNA-binding transcription factor activity
DN051_RS22590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DN051_RS22590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DN051_RS22590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DN051_RS22600	COG1376	ErfK ybiS ycfS ynhG family protein
DN051_RS22605	COG3191	aminopeptidase activity
DN051_RS22620	COG1970	mechanosensitive ion channel activity
DN051_RS22630	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DN051_RS22660	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DN051_RS22665	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DN051_RS22675	COG0315	cyclic pyranopterin monophosphate synthase activity
DN051_RS22680	COG0315	cyclic pyranopterin monophosphate synthase activity
DN051_RS22680	COG0521	Mo-molybdopterin cofactor biosynthetic process
DN051_RS22685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN051_RS22705	COG0708	Exodeoxyribonuclease III
DN051_RS22715	COG2072	flavoprotein involved in K transport
DN051_RS22720	COG2267	carboxylic ester hydrolase activity
DN051_RS22725	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS22750	COG2409	Drug exporters of the RND superfamily
DN051_RS22755	COG0442	prolyl-tRNA aminoacylation
DN051_RS22775	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DN051_RS22780	COG1122	ATPase activity
DN051_RS22790	COG0310	cobalt ion transport
DN051_RS22825	COG0084	hydrolase, TatD family'
DN051_RS22835	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DN051_RS22840	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DN051_RS22845	COG0488	(ABC) transporter
DN051_RS22885	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DN051_RS22895	COG2197	response regulator
DN051_RS22905	COG4106	trans-aconitate 2-methyltransferase activity
DN051_RS22910	COG1309	transcriptional regulator
DN051_RS22920	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DN051_RS22930	COG0193	aminoacyl-tRNA hydrolase activity
DN051_RS22935	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DN051_RS22940	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DN051_RS22945	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DN051_RS22960	COG4585	Histidine kinase
DN051_RS22990	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DN051_RS23000	COG2814	Major facilitator Superfamily
DN051_RS23005	COG1136	(ABC) transporter
DN051_RS23010	COG0577	efflux transmembrane transporter activity
DN051_RS23090	COG2124	cytochrome p450
DN051_RS23105	COG0148	phosphopyruvate hydratase activity
DN051_RS23125	COG1252	NADH dehydrogenase
DN051_RS23130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DN051_RS23135	COG0577	efflux transmembrane transporter activity
DN051_RS23170	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DN051_RS23175	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DN051_RS23215	COG0183	Belongs to the thiolase family
DN051_RS23220	COG2755	lipolytic protein G-D-S-L family
DN051_RS23235	COG2986	histidine ammonia-lyase
DN051_RS23275	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DN051_RS23290	COG1228	amidohydrolase
DN051_RS23300	COG1191	sigma factor activity
DN051_RS23305	COG1366	Belongs to the anti-sigma-factor antagonist family
DN051_RS23335	COG3104	oligopeptide transport
DN051_RS23340	COG0745	RESPONSE REGULATOR receiver
DN051_RS23345	COG2205	protein histidine kinase activity
DN051_RS23360	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DN051_RS23385	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DN051_RS23405	COG1316	TRANSCRIPTIONal
DN051_RS23415	COG1316	TRANSCRIPTIONal
DN051_RS23420	COG0463	Glycosyl transferase, family 2
DN051_RS23430	COG1316	TRANSCRIPTIONal
DN051_RS23435	COG1316	TRANSCRIPTIONal
DN051_RS23440	COG1316	TRANSCRIPTIONal
DN051_RS23465	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
DN051_RS23465	COG0778	Nitroreductase
DN051_RS23470	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DN051_RS23505	COG1620	l-lactate permease
DN051_RS23510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DN051_RS23515	COG2835	tetraacyldisaccharide 4'-kinase activity
DN051_RS23525	COG1482	cell wall glycoprotein biosynthetic process
DN051_RS23535	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DN051_RS23580	COG0714	Associated with various cellular activities
DN051_RS23605	COG0745	RESPONSE REGULATOR receiver
DN051_RS23610	COG5002	protein histidine kinase activity
DN051_RS23610	COG5000	phosphorelay sensor kinase activity
DN051_RS23615	COG0823	Involved in the tonB-independent uptake of proteins
DN051_RS23625	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DN051_RS23630	COG2197	response regulator
DN051_RS23635	COG3214	Protein conserved in bacteria
DN051_RS23645	COG0653	protein targeting
DN051_RS23670	COG2902	Dehydrogenase
DN051_RS23675	COG1134	teichoic acid transport
DN051_RS23695	COG1846	Transcriptional regulator
DN051_RS23700	COG1764	response to oxidative stress
DN051_RS23705	COG1215	transferase activity, transferring glycosyl groups
DN051_RS23710	COG0395	ABC-type sugar transport system, permease component
DN051_RS23715	COG1175	transmembrane transport
DN051_RS23735	COG0515	serine threonine protein kinase
DN051_RS23740	COG0515	serine threonine protein kinase
DN051_RS23745	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DN051_RS23760	COG2884	Cell division ATP-binding protein ftsE
DN051_RS23770	COG0793	Belongs to the peptidase S41A family
DN051_RS23775	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DN051_RS23870	COG2223	nitrite transmembrane transporter activity
DN051_RS23895	COG3973	AAA domain
DN051_RS23905	COG0776	regulation of translation
DN051_RS23910	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DN051_RS23915	COG1678	Uncharacterized ACR, COG1678
DN051_RS23935	COG0395	ABC-type sugar transport system, permease component
DN051_RS23940	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DN051_RS23955	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DN051_RS23985	COG3480	Lon protease (S16) C-terminal proteolytic domain
DN051_RS24015	COG1174	glycine betaine transport
DN051_RS24025	COG1174	glycine betaine transport
DN051_RS24035	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DN051_RS24045	COG0277	FAD linked oxidase domain protein
DN051_RS24060	COG1714	RDD family
DN051_RS24080	COG1335	isochorismatase
DN051_RS24090	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DN051_RS24100	COG1113	amino acid transport
DN051_RS24130	COG1234	tRNA 3'-trailer cleavage
DN051_RS24135	COG1263	PTS System
DN051_RS24140	COG1263	PTS System
DN051_RS24145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DN051_RS24150	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DN051_RS24160	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DN051_RS24190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DN051_RS24205	COG4555	ABC transporter
DN051_RS24220	COG2733	membrane
DN051_RS24225	COG2814	Major facilitator Superfamily
DN051_RS24280	COG3764	Sortase (surface protein transpeptidase)
DN051_RS24300	COG0706	membrane insertase activity
DN051_RS24320	COG4702	Belongs to the UPF0303 family
DN051_RS24325	COG0673	inositol 2-dehydrogenase activity
DN051_RS24330	COG1940	carbohydrate kinase activity
DN051_RS24400	COG3397	chitin binding
DN051_RS24405	COG0318	PFAM AMP-dependent synthetase and ligase
DN051_RS24420	COG1126	abc transporter atp-binding protein
DN051_RS24425	COG0765	amino acid transport
DN051_RS24430	COG0765	amino acid transport
DN051_RS24435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DN051_RS24450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DN051_RS24465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DN051_RS24515	COG0406	alpha-ribazole phosphatase activity
DN051_RS24540	COG0745	RESPONSE REGULATOR receiver
DN051_RS24555	COG0395	ABC-type sugar transport system, permease component
DN051_RS24585	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DN051_RS24590	COG4977	sequence-specific DNA binding
DN051_RS24600	COG0589	response to stress
DN051_RS24610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DN051_RS24640	COG3486	L-lysine 6-monooxygenase (NADPH) activity
DN051_RS24670	COG3409	Peptidoglycan-binding domain 1 protein
DN051_RS24675	COG1960	acyl-CoA dehydrogenase activity
DN051_RS24690	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DN051_RS24695	COG1309	transcriptional regulator
DN051_RS24705	COG1946	Acyl-CoA thioesterase
DN051_RS24720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DN051_RS24730	COG0028	Belongs to the TPP enzyme family
DN051_RS24760	COG1472	Belongs to the glycosyl hydrolase 3 family
DN051_RS24795	COG0673	inositol 2-dehydrogenase activity
DN051_RS24810	COG1869	D-ribose catabolic process
DN051_RS24815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DN051_RS24820	COG1879	ABC-type sugar transport system periplasmic component
DN051_RS24825	COG1129	ABC transporter
DN051_RS24830	COG1609	Transcriptional regulator
DN051_RS24840	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DN051_RS24865	COG2409	Drug exporters of the RND superfamily
DN051_RS24875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN051_RS24885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DN051_RS24895	COG3718	enzyme involved in inositol metabolism
DN051_RS24900	COG3962	Belongs to the TPP enzyme family
DN051_RS24915	COG1131	(ABC) transporter
DN051_RS24930	COG0492	ferredoxin-NADP+ reductase activity
DN051_RS24950	COG0438	transferase activity, transferring glycosyl groups
DN051_RS24970	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DN051_RS24975	COG0438	transferase activity, transferring glycosyl groups
DN051_RS25000	COG2304	oxidoreductase activity
DN051_RS25045	COG0629	single-stranded DNA binding
DN051_RS25075	COG1136	(ABC) transporter
DN051_RS25075	COG0577	efflux transmembrane transporter activity
DN051_RS25090	COG2346	COG2346, Truncated hemoglobins
DN051_RS25095	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DN051_RS25125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DN051_RS25140	COG1486	melibiose metabolic process
DN051_RS25145	COG0395	ABC-type sugar transport system, permease component
DN051_RS25150	COG1175	transmembrane transport
DN051_RS25155	COG1653	transport
DN051_RS25165	COG0668	transmembrane transport
DN051_RS25180	COG1136	(ABC) transporter
DN051_RS25260	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DN051_RS25270	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DN051_RS25275	COG1113	amino acid transport
DN051_RS25280	COG1268	BioY protein
DN051_RS25290	COG0515	serine threonine protein kinase
DN051_RS25295	COG1113	amino acid transport
DN051_RS25310	COG4552	Acetyltransferase involved in intracellular survival and related
DN051_RS25325	COG3594	Acyltransferase
DN051_RS25345	COG0544	peptidyl-prolyl cis-trans isomerase activity
DN051_RS25350	COG0740	serine-type endopeptidase activity
DN051_RS25355	COG0740	serine-type endopeptidase activity
DN051_RS25360	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DN051_RS25370	COG0525	valine-tRNA ligase activity
DN051_RS25375	COG0285	dihydrofolate synthase activity
DN051_RS25385	COG0105	UTP biosynthetic process
DN051_RS25390	COG1077	Cell shape determining protein MreB Mrl
DN051_RS25405	COG0768	penicillin binding
DN051_RS25410	COG0772	Belongs to the SEDS family
DN051_RS25495	COG1530	ribonuclease E activity
DN051_RS25500	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DN051_RS25505	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DN051_RS25510	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DN051_RS25520	COG3540	Alkaline phosphatase
DN051_RS25540	COG0463	Glycosyl transferase, family 2
DN051_RS25550	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DN051_RS25560	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DN051_RS25580	COG0501	Belongs to the peptidase M48B family
DN051_RS25590	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DN051_RS25600	COG0799	negative regulation of ribosome biogenesis
DN051_RS25605	COG0588	phosphoglycerate mutase activity
DN051_RS25635	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DN051_RS25650	COG0495	leucyl-tRNA aminoacylation
DN051_RS25660	COG1307	EDD domain protein, DegV family
DN051_RS25665	COG1596	polysaccharide export
DN051_RS25665	COG1555	photosystem II stabilization
DN051_RS25675	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DN051_RS25690	COG0268	Binds directly to 16S ribosomal RNA
DN051_RS25700	COG0481	GTPase activity
DN051_RS25720	COG1160	GTP binding
DN051_RS25740	COG1420	regulation of RNA biosynthetic process
DN051_RS25745	COG0484	heat shock protein binding
DN051_RS25775	COG0793	Belongs to the peptidase S41A family
DN051_RS25775	COG4946	Tricorn protease homolog
DN051_RS25780	COG0537	adenosine 5'-monophosphoramidase activity
DN051_RS25785	COG1234	tRNA 3'-trailer cleavage
DN051_RS25790	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DN051_RS25805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DN051_RS25810	COG4948	Mandelate Racemase Muconate Lactonizing
DN051_RS25825	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DN051_RS25850	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DN051_RS25855	COG2723	6-phospho-beta-galactosidase activity
DN051_RS25875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DN051_RS25890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DN051_RS25895	COG4608	Belongs to the ABC transporter superfamily
DN051_RS25900	COG0444	Belongs to the ABC transporter superfamily
DN051_RS25910	COG0747	negative chemotaxis
DN051_RS25925	COG1595	DNA-templated transcription, initiation
DN051_RS25950	COG1381	Involved in DNA repair and RecF pathway recombination
DN051_RS25955	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DN051_RS25965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DN051_RS25970	COG1121	(ABC) transporter
DN051_RS25975	COG3443	Belongs to the bacterial solute-binding protein 9 family
DN051_RS25975	COG0803	Belongs to the bacterial solute-binding protein 9 family
DN051_RS25980	COG0423	glycine-tRNA ligase activity
DN051_RS25990	COG0667	Aldo Keto reductase
DN051_RS26025	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
DN051_RS26030	COG1846	Transcriptional regulator
DN051_RS26030	COG1940	carbohydrate kinase activity
DN051_RS26035	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DN051_RS26035	COG0574	Belongs to the PEP-utilizing enzyme family
DN051_RS26070	COG2146	nitrite reductase [NAD(P)H] activity
DN051_RS26070	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DN051_RS26075	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DN051_RS26110	COG0243	molybdopterin cofactor binding
DN051_RS26115	COG2949	membrane
DN051_RS26125	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DN051_RS26135	COG0358	DNA primase activity
DN051_RS26140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DN051_RS26155	COG1070	Carbohydrate kinase
DN051_RS26185	COG2909	trisaccharide binding
DN051_RS26220	COG1077	Cell shape determining protein MreB Mrl
DN051_RS26225	COG0825	malonyl-CoA metabolic process
DN051_RS26225	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DN051_RS26230	COG0318	PFAM AMP-dependent synthetase and ligase
DN051_RS26240	COG2186	Transcriptional regulator
DN051_RS26285	COG4981	capsule polysaccharide biosynthetic process
DN051_RS26305	COG1414	Transcriptional regulator
DN051_RS26310	COG3386	PFAM SMP-30 Gluconolaconase
DN051_RS26350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DN051_RS26360	COG4214	carbohydrate transport
DN051_RS26385	COG4948	Mandelate Racemase Muconate Lactonizing
DN051_RS26410	COG1120	ATPase activity
DN051_RS26420	COG2130	NADP-dependent
DN051_RS26425	COG1764	response to oxidative stress
DN051_RS26470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DN051_RS26475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DN051_RS26480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DN051_RS26495	COG1741	Belongs to the pirin family
DN051_RS26505	COG0789	Transcriptional regulator
DN051_RS26510	COG0667	Aldo Keto reductase
DN051_RS26525	COG1309	transcriptional regulator
DN051_RS26530	COG0477	Major facilitator Superfamily
DN051_RS26535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DN051_RS26540	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DN051_RS26585	COG1358	cellular component organization or biogenesis
DN051_RS26595	COG0586	Pfam SNARE associated Golgi protein
DN051_RS26625	COG0076	glutamate decarboxylase activity
DN051_RS26650	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DN051_RS26720	COG4122	O-methyltransferase activity
DN051_RS26750	COG0183	Belongs to the thiolase family
DN051_RS26755	COG2124	cytochrome p450
DN051_RS26760	COG1388	LysM domain
DN051_RS26770	COG3845	ABC transporter
DN051_RS26790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN051_RS26805	COG1309	transcriptional regulator
DN051_RS26810	COG0438	transferase activity, transferring glycosyl groups
DN051_RS26830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DN051_RS26840	COG0860	N-Acetylmuramoyl-L-alanine amidase
DN051_RS26840	COG2247	cell wall binding repeat
DN051_RS26850	COG0477	Major facilitator Superfamily
DN051_RS26860	COG2030	dehydratase
DN051_RS26880	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DN051_RS26895	COG0800	Aldolase
DN051_RS26900	COG3022	response to hydroperoxide
DN051_RS26980	COG2259	Doxx family
DN051_RS26990	COG0667	Aldo Keto reductase
DN051_RS26995	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS27000	COG3540	Alkaline phosphatase
DN051_RS27005	COG0673	inositol 2-dehydrogenase activity
DN051_RS27010	COG2814	Major facilitator Superfamily
DN051_RS27015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DN051_RS27095	COG1994	Peptidase M50
DN051_RS27115	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DN051_RS27120	COG0477	Major facilitator Superfamily
DN051_RS27135	COG2814	Major facilitator Superfamily
DN051_RS27140	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DN051_RS27140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DN051_RS27155	COG0174	glutamine synthetase
DN051_RS27175	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DN051_RS27185	COG1609	Transcriptional regulator
DN051_RS27190	COG1653	transport
DN051_RS27195	COG1175	transmembrane transport
DN051_RS27200	COG3833	ABC-type maltose transport systems, permease component
DN051_RS27205	COG0366	Alpha amylase catalytic
DN051_RS27245	COG2197	response regulator
DN051_RS27260	COG0745	RESPONSE REGULATOR receiver
DN051_RS27305	COG0501	Belongs to the peptidase M48B family
DN051_RS27330	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DN051_RS27335	COG2188	Transcriptional regulator
DN051_RS27395	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DN051_RS27400	COG0174	glutamine synthetase
DN051_RS27420	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DN051_RS27425	COG0321	lipoyl(octanoyl) transferase activity
DN051_RS27470	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DN051_RS27480	COG0508	dehydrogenase complex catalyzes the overall conversion of
DN051_RS27485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DN051_RS27490	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DN051_RS27520	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DN051_RS27530	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DN051_RS27550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DN051_RS27555	COG2226	methyltransferase
DN051_RS27575	COG4585	Histidine kinase
DN051_RS27580	COG2197	response regulator
DN051_RS27585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DN051_RS27590	COG0515	serine threonine protein kinase
DN051_RS27590	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DN051_RS27595	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DN051_RS27615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DN051_RS27620	COG1104	cysteine desulfurase activity
DN051_RS27625	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DN051_RS27630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DN051_RS27640	COG1376	ErfK ybiS ycfS ynhG family protein
DN051_RS27650	COG1845	cytochrome c oxidase, subunit III
DN051_RS27655	COG2010	Cytochrome c
DN051_RS27660	COG0723	plastoquinol--plastocyanin reductase activity
DN051_RS27665	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DN051_RS27670	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DN051_RS27675	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DN051_RS27705	COG0791	NLP P60 protein
DN051_RS27705	COG3883	PFAM NLP P60 protein
DN051_RS27720	COG0438	transferase activity, transferring glycosyl groups
DN051_RS27740	COG0003	Pfam Anion-transporting ATPase
DN051_RS27750	COG1940	carbohydrate kinase activity
DN051_RS27780	COG2197	response regulator
DN051_RS27785	COG0205	6-phosphofructokinase activity
DN051_RS27790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DN051_RS27805	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DN051_RS27815	COG2193	ferroxidase activity
DN051_RS27820	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DN051_RS27830	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DN051_RS27835	COG2815	serine threonine protein kinase
DN051_RS27835	COG0515	serine threonine protein kinase
DN051_RS27840	COG2022	thiamine diphosphate biosynthetic process
DN051_RS27850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DN051_RS27850	COG2022	thiamine diphosphate biosynthetic process
DN051_RS27870	COG0352	thiamine-phosphate diphosphorylase activity
DN051_RS27895	COG1309	transcriptional regulator
DN051_RS27905	COG1129	ABC transporter
DN051_RS27915	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DN051_RS27935	COG0714	Associated with various cellular activities
DN051_RS27945	COG0275	rRNA processing
DN051_RS27955	COG0768	penicillin binding
DN051_RS27960	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DN051_RS27970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DN051_RS27975	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DN051_RS27985	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DN051_RS27990	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DN051_RS27995	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DN051_RS28000	COG1496	oxidoreductase activity
DN051_RS28010	COG1799	cell septum assembly
DN051_RS28020	COG3599	regulation of cell shape
DN051_RS28025	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DN051_RS28040	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DN051_RS28090	COG0587	DNA-directed DNA polymerase activity
DN051_RS28095	COG1432	Conserved Protein
DN051_RS28130	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DN051_RS28135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DN051_RS28140	COG0131	Imidazoleglycerol-phosphate dehydratase
DN051_RS28145	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DN051_RS28150	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DN051_RS28155	COG0251	oxidation-reduction process
DN051_RS28160	COG0107	imidazoleglycerol-phosphate synthase activity
DN051_RS28175	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DN051_RS28200	COG0134	indole-3-glycerol-phosphate synthase activity
DN051_RS28210	COG0133	tryptophan synthase activity
DN051_RS28215	COG0159	tryptophan synthase activity
DN051_RS28225	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DN051_RS28235	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DN051_RS28240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DN051_RS28270	COG0067	glutamate synthase
DN051_RS28270	COG0069	glutamate synthase activity
DN051_RS28270	COG0070	glutamate synthase
DN051_RS28285	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DN051_RS28290	COG1960	acyl-CoA dehydrogenase activity
DN051_RS28295	COG1960	acyl-CoA dehydrogenase activity
DN051_RS28300	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS28305	COG1309	transcriptional regulator
DN051_RS28330	COG1024	Enoyl-CoA hydratase
DN051_RS28345	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS28355	COG5640	endopeptidase activity
DN051_RS28365	COG0287	Prephenate dehydrogenase
DN051_RS28365	COG1605	Chorismate mutase
DN051_RS28370	COG0745	RESPONSE REGULATOR receiver
DN051_RS28390	COG0737	Belongs to the 5'-nucleotidase family
DN051_RS28425	COG0411	ABC transporter
DN051_RS28455	COG2050	protein possibly involved in aromatic compounds catabolism
DN051_RS28495	COG1643	Atp-dependent helicase
DN051_RS28515	COG0237	dephospho-CoA kinase activity
DN051_RS28530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DN051_RS28565	COG0402	S-adenosylhomocysteine deaminase activity
DN051_RS28600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN051_RS28605	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DN051_RS28640	COG0598	Magnesium transport protein CorA
DN051_RS28645	COG2226	methyltransferase
DN051_RS28655	COG2313	pseudouridylate synthase activity
DN051_RS28675	COG0556	nucleotide-excision repair
DN051_RS28695	COG0387	Pfam Sodium calcium exchanger
DN051_RS28700	COG0477	Major facilitator Superfamily
DN051_RS28705	COG1619	proteins homologs of microcin C7 resistance protein MccF
DN051_RS28710	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DN051_RS28715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN051_RS28725	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DN051_RS28750	COG0723	plastoquinol--plastocyanin reductase activity
DN051_RS28760	COG0322	excinuclease ABC activity
DN051_RS28765	COG1660	Displays ATPase and GTPase activities
DN051_RS28770	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DN051_RS28775	COG1481	regulation of sporulation
DN051_RS28785	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DN051_RS28790	COG0126	phosphoglycerate kinase activity
DN051_RS28795	COG0149	triose-phosphate isomerase activity
DN051_RS28800	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DN051_RS28810	COG0166	Belongs to the GPI family
DN051_RS28820	COG1136	(ABC) transporter
DN051_RS28820	COG0577	efflux transmembrane transporter activity
DN051_RS28825	COG1695	Transcriptional regulator
DN051_RS28835	COG0366	Alpha amylase catalytic
DN051_RS28840	COG1653	transport
DN051_RS28845	COG1175	transmembrane transport
DN051_RS28850	COG0395	ABC-type sugar transport system, permease component
DN051_RS28855	COG0363	glucosamine-6-phosphate deaminase activity
DN051_RS28870	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DN051_RS28885	COG0109	protoheme IX farnesyltransferase activity
DN051_RS28905	COG1612	heme a metabolic process
DN051_RS28915	COG1131	(ABC) transporter
DN051_RS28920	COG2746	aminoglycoside 3-N-acetyltransferase activity
DN051_RS28935	COG0719	Fe-S assembly protein
DN051_RS28945	COG0396	ATPase activity
DN051_RS28950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DN051_RS28955	COG0822	iron-sulfur transferase activity
DN051_RS28960	COG2151	metal-sulfur cluster biosynthetic enzyme
DN051_RS28970	COG3226	Transcriptional regulator
DN051_RS28975	COG2171	N-acyltransferase activity
DN051_RS28985	COG1595	DNA-templated transcription, initiation
DN051_RS28995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DN051_RS29045	COG1063	alcohol dehydrogenase
DN051_RS29050	COG0395	ABC-type sugar transport system, permease component
DN051_RS29065	COG1349	DNA-binding transcription factor activity
DN051_RS29070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DN051_RS29075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DN051_RS29090	COG1802	Transcriptional regulator
DN051_RS29095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DN051_RS29105	COG1175	transmembrane transport
DN051_RS29110	COG0395	ABC-type sugar transport system, permease component
DN051_RS29140	COG2252	PERMEase
DN051_RS29145	COG1414	Transcriptional regulator
DN051_RS29180	COG5285	phytanoyl-CoA dioxygenase
DN051_RS29185	COG1917	Cupin 2, conserved barrel domain protein
DN051_RS29190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DN051_RS29195	COG0456	acetyltransferase
DN051_RS29200	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DN051_RS29210	COG0765	amino acid transport
DN051_RS29275	COG1797	cobyrinic acid a,c-diamide synthase activity
DN051_RS29280	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DN051_RS29295	COG1492	cobalamin metabolic process
DN051_RS29320	COG0235	Class ii aldolase
DN051_RS29345	COG0488	(ABC) transporter
DN051_RS29355	COG1024	Enoyl-CoA hydratase
DN051_RS29395	COG3387	PFAM Glycoside hydrolase 15-related
DN051_RS29410	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DN051_RS29450	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DN051_RS29455	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DN051_RS29475	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DN051_RS29490	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS29505	COG2186	Transcriptional regulator
DN051_RS29530	COG3830	Belongs to the UPF0237 family
DN051_RS29530	COG0560	Phosphoserine phosphatase
DN051_RS29540	COG0842	Transport permease protein
DN051_RS29540	COG1131	(ABC) transporter
DN051_RS29540	COG1716	ATPase activity
DN051_RS29550	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DN051_RS29555	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS29560	COG4585	Histidine kinase
DN051_RS29565	COG2197	response regulator
DN051_RS29580	COG1119	ATPase activity
DN051_RS29600	COG1881	PFAM PEBP family protein
DN051_RS29610	COG2094	Belongs to the DNA glycosylase MPG family
DN051_RS29645	COG0647	UMP catabolic process
DN051_RS29650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN051_RS29655	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN051_RS29660	COG1120	ATPase activity
DN051_RS29680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DN051_RS29685	COG0497	DNA recombination
DN051_RS29720	COG3387	PFAM Glycoside hydrolase 15-related
DN051_RS29725	COG0504	CTP synthase activity
DN051_RS29730	COG0494	nUDIX hydrolase
DN051_RS29740	COG0686	Belongs to the AlaDH PNT family
DN051_RS29755	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DN051_RS29760	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DN051_RS29765	COG1187	pseudouridine synthase activity
DN051_RS29795	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DN051_RS29805	COG1160	GTP binding
DN051_RS29830	COG0411	ABC transporter
DN051_RS29860	COG0671	phosphoesterase, PA-phosphatase related
DN051_RS29870	COG0477	Major facilitator Superfamily
DN051_RS29875	COG1960	acyl-CoA dehydrogenase activity
DN051_RS29880	COG1799	cell septum assembly
DN051_RS29895	COG0330	HflC and HflK could
DN051_RS29910	COG0587	DNA-directed DNA polymerase activity
DN051_RS29945	COG1725	Transcriptional regulator
DN051_RS29995	COG2755	lipolytic protein G-D-S-L family
DN051_RS30000	COG2815	serine threonine protein kinase
DN051_RS30000	COG0515	serine threonine protein kinase
DN051_RS30020	COG1595	DNA-templated transcription, initiation
DN051_RS30045	COG2188	Transcriptional regulator
DN051_RS30050	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DN051_RS30060	COG1309	transcriptional regulator
DN051_RS30065	COG0243	molybdopterin cofactor binding
DN051_RS30070	COG2851	Citrate transporter
DN051_RS30100	COG0640	Transcriptional regulator
DN051_RS30110	COG1960	acyl-CoA dehydrogenase activity
DN051_RS30130	COG0789	Transcriptional regulator
DN051_RS30135	COG0072	phenylalanine-tRNA ligase activity
DN051_RS30135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DN051_RS30150	COG3876	Protein conserved in bacteria
DN051_RS30155	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS30160	COG0318	PFAM AMP-dependent synthetase and ligase
DN051_RS30170	COG1960	acyl-CoA dehydrogenase activity
DN051_RS30190	COG2149	membrane
DN051_RS30195	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DN051_RS30225	COG3265	gluconokinase activity
DN051_RS30230	COG2186	Transcriptional regulator
DN051_RS30235	COG3012	SEC-C Motif Domain Protein
DN051_RS30240	COG0308	aminopeptidase N
DN051_RS30255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DN051_RS30285	COG0667	Aldo Keto reductase
DN051_RS30290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DN051_RS30300	COG0598	Magnesium transport protein CorA
DN051_RS30305	COG0588	phosphoglycerate mutase activity
DN051_RS30320	COG0215	cysteine-tRNA ligase activity
DN051_RS30330	COG2186	Transcriptional regulator
DN051_RS30335	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DN051_RS30340	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DN051_RS30345	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DN051_RS30350	COG1414	Transcriptional regulator
DN051_RS30355	COG0646	methionine synthase
DN051_RS30355	COG1410	methionine synthase
DN051_RS30360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DN051_RS30365	COG0747	negative chemotaxis
DN051_RS30370	COG4166	transmembrane transport
DN051_RS30375	COG2197	response regulator
DN051_RS30385	COG1994	Peptidase M50
DN051_RS30385	COG0517	IMP dehydrogenase activity
DN051_RS30410	COG1222	aaa ATPase
DN051_RS30415	COG4122	O-methyltransferase activity
DN051_RS30430	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DN051_RS30435	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DN051_RS30440	COG1609	Transcriptional regulator
DN051_RS30450	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DN051_RS30455	COG0545	Peptidyl-prolyl cis-trans isomerase
DN051_RS30485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DN051_RS30490	COG0805	protein transport
DN051_RS30540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DN051_RS30545	COG4175	Glycine betaine
DN051_RS30545	COG0517	IMP dehydrogenase activity
DN051_RS30550	COG4176	ABC-type proline glycine betaine transport system permease component
DN051_RS30560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DN051_RS30575	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DN051_RS30585	COG0174	glutamine synthetase
DN051_RS30590	COG1012	belongs to the aldehyde dehydrogenase family
DN051_RS30635	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DN051_RS30640	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DN051_RS30645	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DN051_RS30650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DN051_RS30655	COG5002	protein histidine kinase activity
DN051_RS30660	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DN051_RS30665	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DN051_RS30665	COG0072	phenylalanine-tRNA ligase activity
DN051_RS30700	COG1649	PFAM Uncharacterised BCR, COG1649
DN051_RS30710	COG0697	spore germination
DN051_RS30740	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DN051_RS30745	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DN051_RS30750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DN051_RS30755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DN051_RS30760	COG1438	arginine binding
DN051_RS30765	COG2226	methyltransferase
DN051_RS30800	COG0137	argininosuccinate synthase activity
DN051_RS30810	COG0165	Argininosuccinate lyase
DN051_RS30825	COG0477	Major facilitator Superfamily
DN051_RS30830	COG0745	RESPONSE REGULATOR receiver
DN051_RS30835	COG2205	protein histidine kinase activity
DN051_RS30840	COG0318	PFAM AMP-dependent synthetase and ligase
DN051_RS30840	COG0204	Acyl-transferase
DN051_RS30845	COG0584	glycerophosphoryl diester phosphodiesterase
DN051_RS30875	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DN051_RS30880	COG2011	ABC-type metal ion transport system permease component
DN051_RS30885	COG1464	Belongs to the NlpA lipoprotein family
DN051_RS30890	COG1464	Belongs to the NlpA lipoprotein family
DN051_RS30905	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DN051_RS30910	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DN051_RS30910	COG1648	precorrin-2 dehydrogenase activity
DN051_RS30965	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DN051_RS31010	COG1653	transport
DN051_RS31015	COG1175	transmembrane transport
DN051_RS31020	COG0395	ABC-type sugar transport system, permease component
DN051_RS31040	COG5002	protein histidine kinase activity
DN051_RS31040	COG2176	DNA-directed DNA polymerase activity
DN051_RS31055	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DN051_RS31060	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DN051_RS31085	COG1560	Kdo2-lipid A biosynthetic process
DN051_RS31090	COG0438	transferase activity, transferring glycosyl groups
DN051_RS31110	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DN051_RS31115	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DN051_RS31120	COG0217	transcriptional regulatory protein
DN051_RS31125	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DN051_RS31130	COG0632	four-way junction helicase activity
DN051_RS31135	COG2255	four-way junction helicase activity
DN051_RS31145	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DN051_RS31150	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DN051_RS31155	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DN051_RS31160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DN051_RS31165	COG1196	nuclear chromosome segregation
DN051_RS31170	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DN051_RS31180	COG0124	histidyl-tRNA synthetase
DN051_RS31195	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DN051_RS31210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DN051_RS31215	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DN051_RS31220	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DN051_RS31225	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DN051_RS31230	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DN051_RS31235	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DN051_RS31240	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DN051_RS31250	COG0006	proline dipeptidase activity
DN051_RS31255	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DN051_RS31260	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DN051_RS31270	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DN051_RS31275	COG0540	Belongs to the ATCase OTCase family
DN051_RS31280	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DN051_RS31290	COG0505	Belongs to the CarA family
DN051_RS31295	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DN051_RS31300	COG0167	dihydroorotate dehydrogenase activity
DN051_RS31305	COG0284	orotidine-5'-phosphate decarboxylase activity
DN051_RS31315	COG0194	GDP metabolic process
DN051_RS31320	COG1758	RNA polymerase activity
DN051_RS31330	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DN051_RS31345	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DN051_RS31355	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DN051_RS31360	COG2390	Transcriptional regulator
DN051_RS31400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DN051_RS31420	COG2233	PERMEase
DN051_RS31425	COG0738	Major facilitator superfamily
DN051_RS31430	COG1940	carbohydrate kinase activity
DN051_RS31430	COG1846	Transcriptional regulator
DN051_RS31445	COG3201	nicotinamide mononucleotide transporter
DN051_RS31450	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DN051_RS31450	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DN051_RS31455	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DN051_RS31460	COG0140	phosphoribosyl-ATP diphosphatase activity
DN051_RS31465	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DN051_RS31490	COG0237	dephospho-CoA kinase activity
DN051_RS31515	COG1960	acyl-CoA dehydrogenase activity
DN051_RS31550	COG0463	Glycosyl transferase, family 2
DN051_RS31565	COG2270	Major facilitator Superfamily
DN051_RS31575	COG2364	Membrane
DN051_RS31615	COG0438	transferase activity, transferring glycosyl groups
DN051_RS31620	COG2755	lipolytic protein G-D-S-L family
DN051_RS31625	COG1984	allophanate hydrolase subunit 2
DN051_RS31630	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DN051_RS31635	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DN051_RS31640	COG4336	lyase activity
DN051_RS31645	COG2814	Major facilitator Superfamily
DN051_RS31680	COG1012	belongs to the aldehyde dehydrogenase family
DN051_RS31690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DN051_RS31705	COG1414	Transcriptional regulator
DN051_RS31710	COG2146	nitrite reductase [NAD(P)H] activity
DN051_RS31715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DN051_RS31735	COG2018	Roadblock/LC7 domain
DN051_RS31755	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DN051_RS31760	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DN051_RS31775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DN051_RS31785	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DN051_RS31800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DN051_RS31810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DN051_RS31845	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DN051_RS31865	COG1716	ATPase activity
DN051_RS31885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DN051_RS31895	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DN051_RS31895	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DN051_RS31910	COG0725	ABC transporter, periplasmic molybdate-binding protein
DN051_RS31950	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DN051_RS31955	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DN051_RS31960	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DN051_RS31995	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DN051_RS32000	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DN051_RS32005	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DN051_RS32030	COG0384	phenazine biosynthesis protein PhzF
DN051_RS32070	COG0697	spore germination
DN051_RS32120	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DN051_RS32135	COG2318	DinB family
DN051_RS32155	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DN051_RS32165	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS32170	COG3896	Chloramphenicol phosphotransferase-like protein
DN051_RS32180	COG1968	undecaprenyl-diphosphatase activity
DN051_RS32200	COG0183	Belongs to the thiolase family
DN051_RS32290	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DN051_RS32470	COG0110	maltose O-acetyltransferase activity
DN051_RS32490	COG0640	Transcriptional regulator
DN051_RS32500	COG1832	CoA-binding protein
DN051_RS32505	COG0215	cysteine-tRNA ligase activity
DN051_RS32515	COG1739	Uncharacterized protein family UPF0029
DN051_RS32555	COG0420	3'-5' exonuclease activity
DN051_RS32560	COG0419	ATPase involved in DNA repair
DN051_RS32565	COG1522	sequence-specific DNA binding
DN051_RS32575	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS32590	COG0626	cystathionine gamma-synthase activity
DN051_RS32650	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DN051_RS32650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DN051_RS32660	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DN051_RS32665	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DN051_RS32695	COG1595	DNA-templated transcription, initiation
DN051_RS32705	COG1940	carbohydrate kinase activity
DN051_RS32720	COG3663	DNA glycosylase
DN051_RS32725	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DN051_RS32750	COG0577	efflux transmembrane transporter activity
DN051_RS32750	COG1136	(ABC) transporter
DN051_RS32755	COG0577	efflux transmembrane transporter activity
DN051_RS32755	COG1136	(ABC) transporter
DN051_RS32770	COG2226	methyltransferase
DN051_RS32775	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DN051_RS32780	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DN051_RS32785	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DN051_RS32825	COG1309	transcriptional regulator
DN051_RS32830	COG0831	urea catabolic process
DN051_RS32835	COG0832	Belongs to the urease beta subunit family
DN051_RS32840	COG0804	urea catabolic process
DN051_RS32850	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DN051_RS32855	COG0829	nickel cation binding
DN051_RS32870	COG0204	Acyl-transferase
DN051_RS32915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DN051_RS32920	COG1834	amidinotransferase
DN051_RS32925	COG1522	sequence-specific DNA binding
DN051_RS32930	COG3279	Response regulator of the LytR AlgR family
DN051_RS32940	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DN051_RS32945	COG3275	phosphorelay sensor kinase activity
DN051_RS32965	COG0205	6-phosphofructokinase activity
DN051_RS32970	COG3442	glutamine amidotransferase
DN051_RS32980	COG0242	peptide deformylase activity
DN051_RS32990	COG1960	acyl-CoA dehydrogenase activity
DN051_RS33000	COG1012	belongs to the aldehyde dehydrogenase family
DN051_RS33010	COG1793	dna ligase
DN051_RS33015	COG0492	ferredoxin-NADP+ reductase activity
DN051_RS33020	COG3800	Transcriptional regulator
DN051_RS33020	COG1396	sequence-specific DNA binding
DN051_RS33030	COG1960	acyl-CoA dehydrogenase activity
DN051_RS33035	COG1960	acyl-CoA dehydrogenase activity
DN051_RS33065	COG1940	carbohydrate kinase activity
DN051_RS33090	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DN051_RS33150	COG2018	Roadblock/LC7 domain
DN051_RS33160	COG1946	Acyl-CoA thioesterase
DN051_RS33175	COG0254	rRNA binding
DN051_RS33185	COG1132	(ABC) transporter
DN051_RS33190	COG1132	(ABC) transporter
DN051_RS33200	COG1132	(ABC) transporter
DN051_RS33205	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DN051_RS33210	COG2072	flavoprotein involved in K transport
DN051_RS33220	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DN051_RS33225	COG1116	anion transmembrane transporter activity
DN051_RS33230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DN051_RS33240	COG3290	protein histidine kinase activity
DN051_RS33255	COG2814	Major facilitator Superfamily
DN051_RS33275	COG0583	DNA-binding transcription factor activity
DN051_RS33305	COG0475	glutathione-regulated potassium exporter activity
DN051_RS33320	COG2124	cytochrome p450
DN051_RS33350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DN051_RS33365	COG2706	6-phosphogluconolactonase activity
DN051_RS33385	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DN051_RS33405	COG1136	(ABC) transporter
DN051_RS33410	COG1136	(ABC) transporter
DN051_RS33410	COG0577	efflux transmembrane transporter activity
DN051_RS33415	COG3409	Peptidoglycan-binding domain 1 protein
DN051_RS33435	COG1960	acyl-CoA dehydrogenase activity
DN051_RS33465	COG1309	transcriptional regulator
DN051_RS33480	COG0671	phosphoesterase, PA-phosphatase related
DN051_RS33495	COG1846	Transcriptional regulator
DN051_RS33515	COG0584	glycerophosphoryl diester phosphodiesterase
DN051_RS33550	COG0204	Acyl-transferase
DN051_RS33570	COG2086	electron transfer activity
DN051_RS33575	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DN051_RS33605	COG1660	Displays ATPase and GTPase activities
DN051_RS33615	COG0445	tRNA wobble uridine modification
DN051_RS33630	COG4585	Histidine kinase
DN051_RS33635	COG2197	response regulator
DN051_RS33680	COG0402	S-adenosylhomocysteine deaminase activity
DN051_RS33685	COG3387	PFAM Glycoside hydrolase 15-related
DN051_RS33695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DN051_RS33700	COG0191	fructose-bisphosphate aldolase activity
DN051_RS33705	COG2813	Specifically methylates the guanine in position
DN051_RS33715	COG1940	carbohydrate kinase activity
DN051_RS33745	COG1349	DNA-binding transcription factor activity
DN051_RS33765	COG0633	Ferredoxin
DN051_RS33765	COG3217	Mosc domain protein beta barrel domain protein
DN051_RS33780	COG1215	transferase activity, transferring glycosyl groups
DN051_RS33785	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DN051_RS33810	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS33830	COG2814	Major facilitator Superfamily
DN051_RS33845	COG4770	biotin carboxylase activity
DN051_RS33850	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DN051_RS33875	COG2326	polyphosphate kinase activity
DN051_RS33880	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DN051_RS33900	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS33905	COG1535	isochorismatase
DN051_RS33905	COG3433	isochorismatase activity
DN051_RS33920	COG0318	PFAM AMP-dependent synthetase and ligase
DN051_RS33945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DN051_RS33950	COG0574	Belongs to the PEP-utilizing enzyme family
DN051_RS33950	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DN051_RS33965	COG2072	flavoprotein involved in K transport
DN051_RS33970	COG2264	protein methyltransferase activity
DN051_RS33975	COG0318	PFAM AMP-dependent synthetase and ligase
DN051_RS33995	COG2409	Drug exporters of the RND superfamily
DN051_RS34000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DN051_RS34015	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DN051_RS34040	COG0640	Transcriptional regulator
DN051_RS34050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DN051_RS34055	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DN051_RS34060	COG2186	Transcriptional regulator
DN051_RS34070	COG2066	Belongs to the glutaminase family
DN051_RS34080	COG5650	phosphatidylinositol metabolic process
DN051_RS34085	COG1686	Belongs to the peptidase S11 family
DN051_RS34090	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DN051_RS34095	COG2226	methyltransferase
DN051_RS34100	COG2188	Transcriptional regulator
DN051_RS34105	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DN051_RS34110	COG3458	cephalosporin-C deacetylase activity
DN051_RS34125	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DN051_RS34135	COG2890	protein-(glutamine-N5) methyltransferase activity
DN051_RS34155	COG1902	pentaerythritol trinitrate reductase activity
DN051_RS34155	COG0446	pyridine nucleotide-disulphide oxidoreductase
DN051_RS34180	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DN051_RS34185	COG1461	Dihydroxyacetone kinase
DN051_RS34190	COG2376	Dihydroxyacetone kinase
DN051_RS34215	COG0667	Aldo Keto reductase
DN051_RS34245	COG0698	ribose 5-phosphate isomerase
DN051_RS34260	COG1960	acyl-CoA dehydrogenase activity
DN051_RS34270	COG0515	serine threonine protein kinase
DN051_RS34275	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DN051_RS34280	COG2070	2-Nitropropane dioxygenase
DN051_RS34295	COG2366	antibiotic biosynthetic process
DN051_RS34320	COG2267	carboxylic ester hydrolase activity
DN051_RS34390	COG0673	inositol 2-dehydrogenase activity
DN051_RS34420	COG0640	Transcriptional regulator
DN051_RS34470	COG1796	DNA polymerase
DN051_RS34470	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DN051_RS34490	COG0346	lactoylglutathione lyase activity
DN051_RS34495	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DN051_RS34505	COG0583	DNA-binding transcription factor activity
DN051_RS34510	COG0667	Aldo Keto reductase
DN051_RS34525	COG0842	Transport permease protein
DN051_RS34525	COG1716	ATPase activity
DN051_RS34525	COG1131	(ABC) transporter
DN051_RS34540	COG1191	sigma factor activity
DN051_RS34545	COG1396	sequence-specific DNA binding
DN051_RS34550	COG0740	serine-type endopeptidase activity
DN051_RS34555	COG0740	serine-type endopeptidase activity
DN051_RS34560	COG0596	Alpha beta hydrolase
DN051_RS34580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DN051_RS34590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DN051_RS34605	COG0328	RNA-DNA hybrid ribonuclease activity
DN051_RS34610	COG2304	oxidoreductase activity
DN051_RS34620	COG0667	Aldo Keto reductase
DN051_RS34635	COG0515	serine threonine protein kinase
DN051_RS34635	COG2815	serine threonine protein kinase
DN051_RS34640	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DN051_RS34650	COG2340	Cysteine-rich secretory protein family
DN051_RS34655	COG1940	carbohydrate kinase activity
DN051_RS34655	COG1846	Transcriptional regulator
DN051_RS34660	COG3345	alpha-galactosidase
DN051_RS34680	COG3852	Histidine kinase
DN051_RS34685	COG0492	ferredoxin-NADP+ reductase activity
DN051_RS34700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN051_RS34785	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DN051_RS34790	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DN051_RS34795	COG3281	Trehalose synthase
DN051_RS34805	COG0366	Alpha amylase catalytic
DN051_RS34850	COG0842	Transport permease protein
DN051_RS34860	COG0181	hydroxymethylbilane synthase activity
DN051_RS34870	COG1793	dna ligase
DN051_RS34870	COG3285	dna ligase
DN051_RS34875	COG2197	response regulator
DN051_RS34885	COG1846	Transcriptional regulator
DN051_RS34920	COG0009	L-threonylcarbamoyladenylate synthase
DN051_RS34935	COG3290	protein histidine kinase activity
DN051_RS34945	COG0596	Alpha beta hydrolase
DN051_RS35020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DN051_RS35025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DN051_RS35095	COG3594	Acyltransferase
DN051_RS35145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DN051_RS35145	COG0519	Catalyzes the synthesis of GMP from XMP
DN051_RS35150	COG3290	protein histidine kinase activity
DN051_RS35250	COG2208	phosphoserine phosphatase activity
DN051_RS35250	COG2770	Histidine kinase
DN051_RS35260	COG1414	Transcriptional regulator
DN051_RS35265	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DN051_RS35315	COG2353	YceI-like domain
DN051_RS35325	COG3485	protocatechuate 3,4-dioxygenase
DN051_RS35335	COG3284	Transcriptional regulator
DN051_RS35365	COG1289	transmembrane transporter activity
DN051_RS35370	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DN051_RS35380	COG1454	alcohol dehydrogenase
DN051_RS35425	COG1271	oxidase subunit
DN051_RS35430	COG1294	oxidase, subunit
DN051_RS35435	COG0025	NhaP-type Na H and K H
DN051_RS35440	COG3387	PFAM Glycoside hydrolase 15-related
DN051_RS35450	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DN051_RS35485	COG1175	transmembrane transport
DN051_RS35490	COG0395	ABC-type sugar transport system, permease component
DN051_RS35505	COG2186	Transcriptional regulator
DN051_RS35510	COG4948	Mandelate Racemase Muconate Lactonizing
DN051_RS35520	COG0800	Aldolase
DN051_RS35525	COG3386	PFAM SMP-30 Gluconolaconase
DN051_RS35535	COG3469	chitinase activity
DN051_RS35565	COG1309	transcriptional regulator
DN051_RS35580	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS35590	COG2080	2 iron, 2 sulfur cluster binding
DN051_RS35595	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DN051_RS35600	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DN051_RS35615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DN051_RS35620	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DN051_RS35625	COG1024	Enoyl-CoA hydratase
DN051_RS35675	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS35680	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DN051_RS35685	COG0277	FAD linked oxidase domain protein
DN051_RS35690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DN051_RS35695	COG1733	regulation of RNA biosynthetic process
DN051_RS35705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DN051_RS35720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DN051_RS35805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DN051_RS35830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DN051_RS35835	COG1024	Enoyl-CoA hydratase
DN051_RS35850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN051_RS35855	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DN051_RS35870	COG3250	beta-galactosidase activity
DN051_RS35875	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DN051_RS35885	COG1404	Belongs to the peptidase S8 family
DN051_RS35890	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS35920	COG0277	FAD linked oxidase domain protein
DN051_RS35925	COG1597	lipid kinase activity
DN051_RS35935	COG1309	transcriptional regulator
DN051_RS35940	COG4221	oxidoreductase activity
DN051_RS35975	COG4106	trans-aconitate 2-methyltransferase activity
DN051_RS35980	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DN051_RS36000	COG1175	transmembrane transport
DN051_RS36005	COG0395	ABC-type sugar transport system, permease component
DN051_RS36015	COG0673	inositol 2-dehydrogenase activity
DN051_RS36020	COG0366	Alpha amylase catalytic
DN051_RS36060	COG2226	methyltransferase
DN051_RS36065	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DN051_RS36085	COG0142	geranyltranstransferase activity
DN051_RS36090	COG3046	protein related to deoxyribodipyrimidine photolyase
DN051_RS36095	COG2409	Drug exporters of the RND superfamily
DN051_RS36100	COG1846	Transcriptional regulator
DN051_RS36145	COG3903	Transcriptional regulator
DN051_RS36145	COG3629	intracellular signal transduction
DN051_RS36180	COG2267	carboxylic ester hydrolase activity
DN051_RS36185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DN051_RS36205	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DN051_RS36205	COG2755	lipolytic protein G-D-S-L family
DN051_RS36225	COG3408	Glycogen debranching enzyme
DN051_RS36245	COG1017	nitric oxide dioxygenase activity
DN051_RS36245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DN051_RS36250	COG1959	2 iron, 2 sulfur cluster binding
DN051_RS36260	COG0509	glycine decarboxylation via glycine cleavage system
DN051_RS36265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DN051_RS36275	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DN051_RS36290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DN051_RS36295	COG3842	ATPase activity
DN051_RS36305	COG1176	ABC-type spermidine putrescine transport system, permease component I
DN051_RS36320	COG0789	Transcriptional regulator
DN051_RS36335	COG1295	ribonuclease BN
DN051_RS36340	COG0477	Major facilitator Superfamily
DN051_RS36345	COG0583	DNA-binding transcription factor activity
DN051_RS36350	COG1309	transcriptional regulator
DN051_RS36385	COG1175	transmembrane transport
DN051_RS36390	COG0395	ABC-type sugar transport system, permease component
DN051_RS36430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DN051_RS36435	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DN051_RS36440	COG0640	Transcriptional regulator
DN051_RS36445	COG2226	methyltransferase
DN051_RS36465	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DN051_RS36465	COG1672	PFAM Archaeal ATPase
DN051_RS36480	COG4221	oxidoreductase activity
DN051_RS36490	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DN051_RS36505	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DN051_RS36520	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS36540	COG0473	3-isopropylmalate dehydrogenase activity
DN051_RS36540	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DN051_RS36600	COG2124	cytochrome p450
DN051_RS36625	COG0395	ABC-type sugar transport system, permease component
DN051_RS36670	COG2124	cytochrome p450
DN051_RS36675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DN051_RS36680	COG1120	ATPase activity
DN051_RS36685	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN051_RS36690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN051_RS36700	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DN051_RS36705	COG0513	Belongs to the DEAD box helicase family
DN051_RS36710	COG1278	Cold shock
DN051_RS36740	COG1404	Belongs to the peptidase S8 family
DN051_RS36775	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DN051_RS36780	COG1741	Belongs to the pirin family
DN051_RS36785	COG0697	spore germination
DN051_RS36790	COG1846	Transcriptional regulator
DN051_RS36795	COG1090	epimerase
DN051_RS36805	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DN051_RS36810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN051_RS36815	COG2197	response regulator
DN051_RS36825	COG1136	(ABC) transporter
DN051_RS36825	COG0577	efflux transmembrane transporter activity
DN051_RS36830	COG0577	efflux transmembrane transporter activity
DN051_RS36830	COG1136	(ABC) transporter
DN051_RS36835	COG1051	belongs to the nudix hydrolase family
DN051_RS36940	COG1414	Transcriptional regulator
DN051_RS36950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DN051_RS36975	COG0477	Major facilitator Superfamily
DN051_RS36990	COG0583	DNA-binding transcription factor activity
DN051_RS36995	COG0473	3-isopropylmalate dehydrogenase activity
DN051_RS37000	COG2211	Major facilitator Superfamily
DN051_RS37005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DN051_RS37030	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DN051_RS37030	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DN051_RS37050	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DN051_RS37060	COG1404	Belongs to the peptidase S8 family
DN051_RS37090	COG2072	flavoprotein involved in K transport
DN051_RS37145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DN051_RS37185	COG0584	glycerophosphoryl diester phosphodiesterase
DN051_RS37250	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DN051_RS37275	COG0514	ATP-dependent DNA helicase (RecQ)
DN051_RS37320	COG0477	Major facilitator Superfamily
DN051_RS37325	COG1309	transcriptional regulator
DN051_RS37335	COG1595	DNA-templated transcription, initiation
DN051_RS37340	COG2226	methyltransferase
DN051_RS37350	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DN051_RS37355	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS37375	COG2855	membrane
DN051_RS37385	COG0583	DNA-binding transcription factor activity
DN051_RS37410	COG0477	Major facilitator Superfamily
DN051_RS37415	COG0667	Aldo Keto reductase
DN051_RS37455	COG3345	alpha-galactosidase
DN051_RS37460	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS37490	COG0789	Transcriptional regulator
DN051_RS37510	COG0477	Major facilitator Superfamily
DN051_RS37515	COG1902	pentaerythritol trinitrate reductase activity
DN051_RS37530	COG0667	Aldo Keto reductase
DN051_RS37535	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DN051_RS37555	COG0640	Transcriptional regulator
DN051_RS37560	COG0346	lactoylglutathione lyase activity
DN051_RS37585	COG1653	transport
DN051_RS37625	COG3547	Transposase (IS116 IS110 IS902 family)
DN051_RS37630	COG3547	Transposase (IS116 IS110 IS902 family)
DN051_RS37635	COG3409	Peptidoglycan-binding domain 1 protein
DN051_RS37640	COG1733	regulation of RNA biosynthetic process
DN051_RS37650	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DN051_RS37735	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DN051_RS37740	COG0395	ABC-type sugar transport system, permease component
DN051_RS37745	COG1175	transmembrane transport
DN051_RS37755	COG2188	Transcriptional regulator
DN051_RS37770	COG2154	pterin-4-alpha-carbinolamine dehydratase
DN051_RS37795	COG1053	succinate dehydrogenase
DN051_RS37835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DN051_RS37850	COG1121	(ABC) transporter
DN051_RS37855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DN051_RS37885	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DN051_RS37900	COG1397	ADP-ribosylglycohydrolase
DN051_RS37905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN051_RS37970	COG3540	Alkaline phosphatase
DN051_RS38015	COG2205	protein histidine kinase activity
DN051_RS38065	COG1404	Belongs to the peptidase S8 family
DN051_RS38095	COG3344	reverse transcriptase
DN051_RS38160	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DN051_RS38235	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS38255	COG1522	sequence-specific DNA binding
DN051_RS38270	COG1846	Transcriptional regulator
DN051_RS38275	COG1404	Belongs to the peptidase S8 family
DN051_RS38295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DN051_RS38310	COG0477	Major facilitator Superfamily
DN051_RS38325	COG3708	Transcriptional regulator
DN051_RS38325	COG2207	Transcriptional regulator
DN051_RS38340	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DN051_RS38345	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DN051_RS38380	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DN051_RS38400	COG1404	Belongs to the peptidase S8 family
DN051_RS38425	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DN051_RS38450	COG2356	endonuclease I
DN051_RS38455	COG1252	NADH dehydrogenase
DN051_RS38475	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS38480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DN051_RS38500	COG1609	Transcriptional regulator
DN051_RS38540	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS38570	COG3618	amidohydrolase
DN051_RS38580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DN051_RS38585	COG4948	Mandelate Racemase Muconate Lactonizing
DN051_RS38590	COG0179	Fumarylacetoacetate (FAA) hydrolase
DN051_RS38595	COG1414	Transcriptional regulator
DN051_RS38600	COG1802	Transcriptional regulator
DN051_RS38670	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DN051_RS38675	COG0187	DNA topoisomerase II activity
DN051_RS38695	COG3864	Putative metallopeptidase domain
DN051_RS38730	COG4608	Belongs to the ABC transporter superfamily
DN051_RS38735	COG0444	Belongs to the ABC transporter superfamily
DN051_RS38740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DN051_RS38745	COG0601	transmembrane transport
DN051_RS38750	COG0747	negative chemotaxis
DN051_RS38755	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DN051_RS38760	COG4948	Mandelate Racemase Muconate Lactonizing
DN051_RS38765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DN051_RS38770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DN051_RS38845	COG0494	nUDIX hydrolase
DN051_RS38850	COG0791	NLP P60 protein
DN051_RS38850	COG3883	PFAM NLP P60 protein
DN051_RS38890	COG5640	endopeptidase activity
DN051_RS38955	COG3384	dioxygenase
DN051_RS38965	COG1309	transcriptional regulator
DN051_RS39010	COG1846	Transcriptional regulator
DN051_RS39020	COG0596	Alpha beta hydrolase
DN051_RS39035	COG3344	reverse transcriptase
DN051_RS39055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN051_RS39060	COG1595	DNA-templated transcription, initiation
DN051_RS39115	COG0577	efflux transmembrane transporter activity
DN051_RS39115	COG1136	(ABC) transporter
DN051_RS39120	COG1136	(ABC) transporter
DN051_RS39125	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DN051_RS39125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DN051_RS39130	COG2197	response regulator
DN051_RS39135	COG4585	Histidine kinase
DN051_RS39285	COG2226	methyltransferase
DN051_RS39400	COG0494	nUDIX hydrolase
DN051_RS39455	COG3547	Transposase (IS116 IS110 IS902 family)
DN051_RS39515	COG0596	Alpha beta hydrolase
DN051_RS39720	COG0596	Alpha beta hydrolase
DN051_RS39760	COG0662	Cupin 2, conserved barrel domain protein
DN051_RS39800	COG2910	NAD(P)H-binding
DN051_RS39815	COG2409	Drug exporters of the RND superfamily
DN051_RS39885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DN051_RS39900	COG1404	Belongs to the peptidase S8 family
DN051_RS39910	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DN051_RS39925	COG0577	efflux transmembrane transporter activity
DN051_RS39930	COG0577	efflux transmembrane transporter activity
DN051_RS39930	COG1136	(ABC) transporter
DN051_RS39945	COG2205	protein histidine kinase activity
DN051_RS39950	COG0745	RESPONSE REGULATOR receiver
DN051_RS39970	COG1404	Belongs to the peptidase S8 family
DN051_RS40020	COG2801	Transposase and inactivated derivatives
DN051_RS40050	COG2318	DinB family
DN051_RS40055	COG2207	Transcriptional regulator
DN051_RS40060	COG0667	Aldo Keto reductase
DN051_RS40100	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DN051_RS40160	COG0582	viral genome integration into host DNA
DN051_RS40295	COG4569	acetaldehyde dehydrogenase (acetylating) activity
DN051_RS40300	COG3971	2-oxopent-4-enoate hydratase activity
DN051_RS40650	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DN051_RS40770	COG4942	peptidase
DN051_RS40800	COG0419	ATPase involved in DNA repair
DN051_RS41005	COG0596	Alpha beta hydrolase
DN051_RS41020	COG0596	Alpha beta hydrolase
DN051_RS41030	COG1073	alpha beta
DN051_RS41055	COG3467	pyridoxamine 5'-phosphate
DN051_RS41080	COG1595	DNA-templated transcription, initiation
DN051_RS41125	COG1846	Transcriptional regulator
DN051_RS41135	COG3655	Transcriptional regulator
DN051_RS41150	COG1316	TRANSCRIPTIONal
DN051_RS41155	COG1611	Belongs to the LOG family
DN051_RS41165	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DN051_RS41185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN051_RS41215	COG2197	response regulator
DN051_RS41220	COG4585	Histidine kinase
DN051_RS41250	COG0583	DNA-binding transcription factor activity
DN051_RS41285	COG0477	Major facilitator Superfamily
DN051_RS41300	COG1522	sequence-specific DNA binding
DN051_RS41320	COG1126	abc transporter atp-binding protein
DN051_RS41325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DN051_RS41340	COG1012	belongs to the aldehyde dehydrogenase family
DN051_RS41340	COG2030	dehydratase
DN051_RS41345	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS41355	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
DN051_RS41365	COG2205	protein histidine kinase activity
DN051_RS41370	COG0745	RESPONSE REGULATOR receiver
DN051_RS41375	COG0577	efflux transmembrane transporter activity
DN051_RS41375	COG1136	(ABC) transporter
DN051_RS41380	COG1136	(ABC) transporter
DN051_RS41380	COG0577	efflux transmembrane transporter activity
DN051_RS41410	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DN051_RS41410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DN051_RS41500	COG1192	Involved in chromosome partitioning
DN051_RS41555	COG0745	RESPONSE REGULATOR receiver
DN051_RS41560	COG2205	protein histidine kinase activity
DN051_RS41605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN051_RS41615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DN051_RS41620	COG0601	transmembrane transport
DN051_RS41625	COG0444	Belongs to the ABC transporter superfamily
DN051_RS41790	COG2197	response regulator
DN051_RS41805	COG1228	amidohydrolase
DN051_RS41810	COG1349	DNA-binding transcription factor activity
DN051_RS41825	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DN051_RS41830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DN051_RS41840	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS41850	COG1960	acyl-CoA dehydrogenase activity
DN051_RS41865	COG0395	ABC-type sugar transport system, permease component
DN051_RS41885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DN051_RS41915	COG2205	protein histidine kinase activity
DN051_RS41920	COG0745	RESPONSE REGULATOR receiver
DN051_RS41935	COG1136	(ABC) transporter
DN051_RS41935	COG0577	efflux transmembrane transporter activity
DN051_RS41940	COG1136	(ABC) transporter
DN051_RS41940	COG0577	efflux transmembrane transporter activity
DN051_RS41995	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DN051_RS42000	COG0675	Transposase, IS605 OrfB family
DN051_RS42010	COG4989	oxidoreductase activity
DN051_RS42025	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DN051_RS42045	COG2197	response regulator
DN051_RS42060	COG1136	(ABC) transporter
DN051_RS42060	COG0577	efflux transmembrane transporter activity
DN051_RS42065	COG0577	efflux transmembrane transporter activity
DN051_RS42065	COG1136	(ABC) transporter
DN051_RS42070	COG0745	RESPONSE REGULATOR receiver
DN051_RS42080	COG2205	protein histidine kinase activity
DN051_RS42105	COG3552	Protein containing von Willebrand factor type A (VWA) domain
DN051_RS42110	COG0714	Associated with various cellular activities
DN051_RS42130	COG0277	FAD linked oxidase domain protein
DN051_RS42200	COG0515	serine threonine protein kinase
DN051_RS42200	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DN051_RS42205	COG0515	serine threonine protein kinase
DN051_RS42205	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DN051_RS42220	COG1902	pentaerythritol trinitrate reductase activity
DN051_RS42230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DN051_RS42260	COG0477	Major facilitator Superfamily
DN051_RS42265	COG3387	PFAM Glycoside hydrolase 15-related
DN051_RS42285	COG0673	inositol 2-dehydrogenase activity
DN051_RS42290	COG1349	DNA-binding transcription factor activity
DN051_RS42345	COG2124	cytochrome p450
DN051_RS42350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DN051_RS42355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DN051_RS42360	COG0367	asparagine synthase
DN051_RS42365	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DN051_RS42370	COG0673	inositol 2-dehydrogenase activity
DN051_RS42390	COG4555	ABC transporter
DN051_RS42400	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DN051_RS42440	COG2801	Transposase and inactivated derivatives
DN051_RS42450	COG3344	reverse transcriptase
DN051_RS42495	COG3547	Transposase (IS116 IS110 IS902 family)
DN051_RS42530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DN051_RS42575	COG1595	DNA-templated transcription, initiation
DN051_RS42600	COG1309	transcriptional regulator
DN051_RS42610	COG0488	(ABC) transporter
DN051_RS42615	COG2197	response regulator
DN051_RS42745	COG2205	protein histidine kinase activity
DN051_RS42750	COG0745	RESPONSE REGULATOR receiver
DN051_RS42755	COG1376	ErfK ybiS ycfS ynhG family protein
DN051_RS42770	COG2197	response regulator
DN051_RS42775	COG4585	Histidine kinase
DN051_RS42780	COG1136	(ABC) transporter
DN051_RS42805	COG0805	protein transport
DN051_RS42815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DN051_RS42915	COG0655	NAD(P)H dehydrogenase (quinone) activity
DN051_RS42965	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DN051_RS42975	COG3246	L-lysine catabolic process to acetate
DN051_RS42990	COG3119	arylsulfatase activity
DN051_RS42995	COG0583	DNA-binding transcription factor activity
DN051_RS43025	COG2197	response regulator
DN051_RS43075	COG1404	Belongs to the peptidase S8 family
DN051_RS43100	COG1960	acyl-CoA dehydrogenase activity
DN051_RS43105	COG2070	2-Nitropropane dioxygenase
DN051_RS43110	COG0583	DNA-binding transcription factor activity
DN051_RS43135	COG1404	Belongs to the peptidase S8 family
DN051_RS43150	COG2197	response regulator
DN051_RS43155	COG2197	response regulator
DN051_RS43165	COG1404	Belongs to the peptidase S8 family
DN051_RS43170	COG1674	ftsk spoiiie
DN051_RS43220	COG1404	Belongs to the peptidase S8 family
DN051_RS43265	COG4221	oxidoreductase activity
DN051_RS43275	COG2364	Membrane
DN051_RS43280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN051_RS43290	COG4552	Acetyltransferase involved in intracellular survival and related
DN051_RS43310	COG2205	protein histidine kinase activity
DN051_RS43400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DN051_RS43405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DN051_RS43415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DN051_RS43425	COG1595	DNA-templated transcription, initiation
DN051_RS43435	COG5002	protein histidine kinase activity
DN051_RS43440	COG0745	RESPONSE REGULATOR receiver
DN051_RS43450	COG1584	GPR1 FUN34 yaaH family protein
DN051_RS43460	COG1404	Belongs to the peptidase S8 family
DN051_RS43465	COG1404	Belongs to the peptidase S8 family
DN051_RS43475	COG0515	serine threonine protein kinase
DN051_RS43495	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DN051_RS43560	COG1404	Belongs to the peptidase S8 family
DN051_RS43580	COG1309	transcriptional regulator
DN051_RS43585	COG1428	Deoxynucleoside kinase
DN051_RS43615	COG0477	Major facilitator Superfamily
DN051_RS43635	COG1404	Belongs to the peptidase S8 family
DN051_RS43655	COG1819	glycosyl
DN051_RS43665	COG1404	Belongs to the peptidase S8 family
DN051_RS43675	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DN051_RS43680	COG1764	response to oxidative stress
DN051_RS43725	COG4133	protoheme IX ABC transporter activity
DN051_RS43825	COG1404	Belongs to the peptidase S8 family
DN051_RS43830	COG2814	Major facilitator Superfamily
DN051_RS43875	COG1609	Transcriptional regulator
DN051_RS43885	COG1176	ABC-type spermidine putrescine transport system, permease component I
DN051_RS43890	COG1177	transmembrane transport
DN051_RS43895	COG3842	ATPase activity
DN051_RS43900	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS44050	COG2801	Transposase and inactivated derivatives
DN051_RS44100	COG0577	efflux transmembrane transporter activity
DN051_RS44100	COG1136	(ABC) transporter
DN051_RS44105	COG0577	efflux transmembrane transporter activity
DN051_RS44110	COG1404	Belongs to the peptidase S8 family
DN051_RS44175	COG1073	alpha beta
DN051_RS44180	COG1073	alpha beta
DN051_RS44185	COG0702	epimerase
DN051_RS44190	COG0667	Aldo Keto reductase
DN051_RS44215	COG3321	synthase
DN051_RS44215	COG1028	Short-chain dehydrogenase reductase Sdr
DN051_RS44215	COG0604	alcohol dehydrogenase
DN051_RS44240	COG2801	Transposase and inactivated derivatives
DN051_RS44265	COG3903	Transcriptional regulator
DN051_RS44265	COG3629	intracellular signal transduction
DN051_RS44300	COG2801	Transposase and inactivated derivatives
DN051_RS44350	COG4221	oxidoreductase activity
DN051_RS44440	COG4552	Acetyltransferase involved in intracellular survival and related
DN051_RS44445	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DN051_RS44500	COG0758	DNA mediated transformation
DN051_RS44570	COG2801	Transposase and inactivated derivatives
DN051_RS44595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease