locus-tag	class	description
B1K54_RS00120	COG2197	response regulator
B1K54_RS00140	COG1185	polyribonucleotide nucleotidyltransferase activity
B1K54_RS00360	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B1K54_RS00370	COG1733	regulation of RNA biosynthetic process
B1K54_RS00380	COG2910	NAD(P)H-binding
B1K54_RS00385	COG2814	Major facilitator Superfamily
B1K54_RS00565	COG0640	Transcriptional regulator
B1K54_RS00615	COG1309	transcriptional regulator
B1K54_RS00655	COG0557	exoribonuclease II activity
B1K54_RS00685	COG4977	sequence-specific DNA binding
B1K54_RS00735	COG1733	regulation of RNA biosynthetic process
B1K54_RS00740	COG0702	epimerase
B1K54_RS00745	COG0187	DNA topoisomerase II activity
B1K54_RS00780	COG3655	Transcriptional regulator
B1K54_RS00840	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B1K54_RS00845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1K54_RS00850	COG1428	Deoxynucleoside kinase
B1K54_RS00925	COG0596	Alpha beta hydrolase
B1K54_RS00940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1K54_RS01060	COG1132	(ABC) transporter
B1K54_RS01080	COG0300	oxidoreductase activity
B1K54_RS01105	COG1051	belongs to the nudix hydrolase family
B1K54_RS01155	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B1K54_RS01200	COG0583	DNA-binding transcription factor activity
B1K54_RS01205	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B1K54_RS01215	COG1113	amino acid transport
B1K54_RS01230	COG0662	Cupin 2, conserved barrel domain protein
B1K54_RS01240	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B1K54_RS01250	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
B1K54_RS01295	COG3293	Transposase
B1K54_RS01315	COG0477	Major facilitator Superfamily
B1K54_RS01325	COG3903	Transcriptional regulator
B1K54_RS01325	COG3629	intracellular signal transduction
B1K54_RS01340	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
B1K54_RS01370	COG3708	Transcriptional regulator
B1K54_RS01370	COG2207	Transcriptional regulator
B1K54_RS01410	COG2770	Histidine kinase
B1K54_RS01410	COG2208	phosphoserine phosphatase activity
B1K54_RS01430	COG0671	phosphoesterase, PA-phosphatase related
B1K54_RS01455	COG4251	negative regulation of phosphorylation
B1K54_RS01460	COG0784	Response regulator, receiver
B1K54_RS01475	COG3387	PFAM Glycoside hydrolase 15-related
B1K54_RS01500	COG0515	serine threonine protein kinase
B1K54_RS01510	COG0668	transmembrane transport
B1K54_RS01535	COG3864	Putative metallopeptidase domain
B1K54_RS01575	COG4977	sequence-specific DNA binding
B1K54_RS01605	COG1309	transcriptional regulator
B1K54_RS01635	COG2197	response regulator
B1K54_RS01670	COG1725	Transcriptional regulator
B1K54_RS01690	COG3795	YCII-related domain
B1K54_RS01695	COG4941	Belongs to the sigma-70 factor family
B1K54_RS01705	COG0318	PFAM AMP-dependent synthetase and ligase
B1K54_RS01715	COG0477	Major facilitator Superfamily
B1K54_RS01755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B1K54_RS01790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B1K54_RS01815	COG1309	transcriptional regulator
B1K54_RS01820	COG1132	(ABC) transporter
B1K54_RS01850	COG1131	(ABC) transporter
B1K54_RS01860	COG1595	DNA-templated transcription, initiation
B1K54_RS01865	COG2124	cytochrome p450
B1K54_RS01920	COG1295	ribonuclease BN
B1K54_RS01935	COG2124	cytochrome p450
B1K54_RS01950	COG2197	response regulator
B1K54_RS01955	COG4585	Histidine kinase
B1K54_RS02050	COG1595	DNA-templated transcription, initiation
B1K54_RS02055	COG0288	reversible hydration of carbon dioxide
B1K54_RS02095	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B1K54_RS02105	COG0509	glycine decarboxylation via glycine cleavage system
B1K54_RS02210	COG2261	transglycosylase associated protein
B1K54_RS02220	COG1028	Short-chain dehydrogenase reductase Sdr
B1K54_RS02240	COG1028	Short-chain dehydrogenase reductase Sdr
B1K54_RS02245	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B1K54_RS02245	COG1796	DNA polymerase
B1K54_RS02250	COG1028	Short-chain dehydrogenase reductase Sdr
B1K54_RS02275	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B1K54_RS02280	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B1K54_RS02285	COG2080	2 iron, 2 sulfur cluster binding
B1K54_RS02295	COG2326	polyphosphate kinase activity
B1K54_RS02310	COG0367	asparagine synthase
B1K54_RS02330	COG1366	Belongs to the anti-sigma-factor antagonist family
B1K54_RS02355	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
B1K54_RS02360	COG2226	methyltransferase
B1K54_RS02370	COG0142	geranyltranstransferase activity
B1K54_RS02405	COG1295	ribonuclease BN
B1K54_RS02410	COG1335	isochorismatase
B1K54_RS02435	COG4974	Belongs to the 'phage' integrase family
B1K54_RS02440	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B1K54_RS02475	COG2226	methyltransferase
B1K54_RS02475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B1K54_RS02475	COG0596	Alpha beta hydrolase
B1K54_RS02485	COG2376	Dihydroxyacetone kinase
B1K54_RS02510	COG1136	(ABC) transporter
B1K54_RS02520	COG1653	transport
B1K54_RS02525	COG0366	Alpha amylase catalytic
B1K54_RS02530	COG1653	transport
B1K54_RS02535	COG1175	transmembrane transport
B1K54_RS02540	COG0395	ABC-type sugar transport system, permease component
B1K54_RS02550	COG2326	polyphosphate kinase activity
B1K54_RS02585	COG0702	epimerase
B1K54_RS02595	COG2249	NAD(P)H dehydrogenase (quinone) activity
B1K54_RS02600	COG3250	beta-galactosidase activity
B1K54_RS02640	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
B1K54_RS02660	COG3046	protein related to deoxyribodipyrimidine photolyase
B1K54_RS02675	COG1902	pentaerythritol trinitrate reductase activity
B1K54_RS02690	COG1316	TRANSCRIPTIONal
B1K54_RS02715	COG0137	argininosuccinate synthase activity
B1K54_RS02745	COG0784	Response regulator, receiver
B1K54_RS02745	COG2205	protein histidine kinase activity
B1K54_RS02745	COG5002	protein histidine kinase activity
B1K54_RS02760	COG1191	sigma factor activity
B1K54_RS02800	COG1959	2 iron, 2 sulfur cluster binding
B1K54_RS02800	COG1295	ribonuclease BN
B1K54_RS02815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B1K54_RS02820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B1K54_RS02860	COG0745	RESPONSE REGULATOR receiver
B1K54_RS02865	COG0642	Histidine kinase
B1K54_RS02880	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B1K54_RS02885	COG4044	May play a role in the intracellular transport of hydrophobic ligands
B1K54_RS02910	COG1476	TRANSCRIPTIONal
B1K54_RS02935	COG1595	DNA-templated transcription, initiation
B1K54_RS02955	COG2135	peptidase activity
B1K54_RS02980	COG3591	Belongs to the peptidase S1B family
B1K54_RS02980	COG1864	DNA RNA non-specific endonuclease
B1K54_RS03015	COG3467	pyridoxamine 5'-phosphate
B1K54_RS03145	COG0028	Belongs to the TPP enzyme family
B1K54_RS03155	COG2890	protein-(glutamine-N5) methyltransferase activity
B1K54_RS03195	COG1733	regulation of RNA biosynthetic process
B1K54_RS03240	COG0574	Belongs to the PEP-utilizing enzyme family
B1K54_RS03240	COG3848	Pyruvate phosphate dikinase
B1K54_RS03305	COG2207	Transcriptional regulator
B1K54_RS03310	COG1028	Short-chain dehydrogenase reductase Sdr
B1K54_RS03330	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B1K54_RS03365	COG1737	Transcriptional regulator
B1K54_RS03420	COG1574	metal-dependent hydrolase with the TIM-barrel fold
B1K54_RS03425	COG1335	isochorismatase
B1K54_RS03430	COG2259	Doxx family
B1K54_RS03445	COG2207	Transcriptional regulator
B1K54_RS03460	COG3896	Chloramphenicol phosphotransferase-like protein
B1K54_RS03495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B1K54_RS03500	COG2267	carboxylic ester hydrolase activity
B1K54_RS03510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B1K54_RS03525	COG0659	secondary active sulfate transmembrane transporter activity
B1K54_RS03540	COG2824	Alkylphosphonate utilization operon protein PhnA
B1K54_RS03575	COG1028	Short-chain dehydrogenase reductase Sdr
B1K54_RS03620	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B1K54_RS03625	COG1011	Hydrolase
B1K54_RS03630	COG1376	ErfK ybiS ycfS ynhG family protein
B1K54_RS03650	COG1505	serine-type exopeptidase activity
B1K54_RS03670	COG4989	oxidoreductase activity
B1K54_RS03695	COG0698	ribose 5-phosphate isomerase
B1K54_RS03705	COG2249	NAD(P)H dehydrogenase (quinone) activity
B1K54_RS03755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1K54_RS03760	COG1252	NADH dehydrogenase
B1K54_RS03800	COG1309	transcriptional regulator
B1K54_RS03815	COG2311	Membrane
B1K54_RS03825	COG4221	oxidoreductase activity
B1K54_RS03830	COG0789	Transcriptional regulator
B1K54_RS03865	COG0431	NADPH-dependent FMN reductase
B1K54_RS03880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B1K54_RS03885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B1K54_RS03920	COG0419	ATPase involved in DNA repair
B1K54_RS03925	COG0420	3'-5' exonuclease activity
B1K54_RS03945	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B1K54_RS03945	COG1796	DNA polymerase
B1K54_RS04000	COG0435	Glutathione S-transferase
B1K54_RS04020	COG3903	Transcriptional regulator
B1K54_RS04020	COG3629	intracellular signal transduction
B1K54_RS04030	COG1595	DNA-templated transcription, initiation
B1K54_RS04070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B1K54_RS04100	COG1404	Belongs to the peptidase S8 family
B1K54_RS04180	COG0583	DNA-binding transcription factor activity
B1K54_RS04185	COG2197	response regulator
B1K54_RS04190	COG4585	Histidine kinase
B1K54_RS04195	COG1136	(ABC) transporter
B1K54_RS04195	COG0577	efflux transmembrane transporter activity
B1K54_RS04210	COG4941	Belongs to the sigma-70 factor family
B1K54_RS04230	COG3118	belongs to the thioredoxin family
B1K54_RS04250	COG1278	Cold shock
B1K54_RS04260	COG1846	Transcriptional regulator
B1K54_RS04265	COG0513	Belongs to the DEAD box helicase family
B1K54_RS04320	COG0492	ferredoxin-NADP+ reductase activity
B1K54_RS04345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1K54_RS04345	COG0072	phenylalanine-tRNA ligase activity
B1K54_RS04350	COG1028	Short-chain dehydrogenase reductase Sdr
B1K54_RS04430	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B1K54_RS04440	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B1K54_RS04475	COG0531	amino acid
B1K54_RS04485	COG2080	2 iron, 2 sulfur cluster binding
B1K54_RS04490	COG2010	Cytochrome c
B1K54_RS04490	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B1K54_RS04510	COG1053	succinate dehydrogenase
B1K54_RS04520	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
B1K54_RS04520	COG1672	PFAM Archaeal ATPase
B1K54_RS04555	COG1024	Enoyl-CoA hydratase
B1K54_RS04565	COG2267	carboxylic ester hydrolase activity
B1K54_RS04620	COG0387	Pfam Sodium calcium exchanger
B1K54_RS04630	COG2070	2-Nitropropane dioxygenase
B1K54_RS04635	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B1K54_RS04670	COG0515	serine threonine protein kinase
B1K54_RS04670	COG2815	serine threonine protein kinase
B1K54_RS04685	COG4257	antibiotic catabolic process
B1K54_RS04690	COG0577	efflux transmembrane transporter activity
B1K54_RS04690	COG1136	(ABC) transporter
B1K54_RS04705	COG1136	(ABC) transporter
B1K54_RS04705	COG4591	ABC-type transport system involved in lipoprotein release permease component
B1K54_RS04710	COG1960	acyl-CoA dehydrogenase activity
B1K54_RS04725	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B1K54_RS04730	COG1349	DNA-binding transcription factor activity
B1K54_RS04745	COG0156	8-amino-7-oxononanoate synthase activity
B1K54_RS04750	COG1063	alcohol dehydrogenase
B1K54_RS04760	COG2226	methyltransferase
B1K54_RS04775	COG3387	PFAM Glycoside hydrolase 15-related
B1K54_RS04780	COG2259	Doxx family
B1K54_RS04815	COG0640	Transcriptional regulator
B1K54_RS04820	COG2814	Major facilitator Superfamily
B1K54_RS04830	COG0714	Associated with various cellular activities
B1K54_RS04845	COG4191	Histidine kinase
B1K54_RS04850	COG1461	Dihydroxyacetone kinase
B1K54_RS04870	COG0725	ABC transporter, periplasmic molybdate-binding protein
B1K54_RS04905	COG1716	ATPase activity
B1K54_RS04905	COG0842	Transport permease protein
B1K54_RS04905	COG1131	(ABC) transporter
B1K54_RS04935	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B1K54_RS04970	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B1K54_RS04985	COG0488	(ABC) transporter
B1K54_RS04990	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B1K54_RS04995	COG0463	Glycosyl transferase, family 2
B1K54_RS05005	COG0633	Ferredoxin
B1K54_RS05005	COG3217	Mosc domain protein beta barrel domain protein
B1K54_RS05015	COG0464	growth
B1K54_RS05045	COG1940	carbohydrate kinase activity
B1K54_RS05115	COG0494	nUDIX hydrolase
B1K54_RS05130	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B1K54_RS05185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1K54_RS05215	COG0671	phosphoesterase, PA-phosphatase related
B1K54_RS05235	COG0493	'glutamate synthase
B1K54_RS05240	COG0640	Transcriptional regulator
B1K54_RS05245	COG1902	pentaerythritol trinitrate reductase activity
B1K54_RS05260	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B1K54_RS05275	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
B1K54_RS05300	COG3903	Transcriptional regulator
B1K54_RS05300	COG3629	intracellular signal transduction
B1K54_RS05315	COG3433	isochorismatase activity
B1K54_RS05315	COG2226	methyltransferase
B1K54_RS05315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B1K54_RS05320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B1K54_RS05385	COG2124	cytochrome p450
B1K54_RS05390	COG3251	PFAM MbtH domain protein
B1K54_RS05425	COG0475	glutathione-regulated potassium exporter activity
B1K54_RS05445	COG0406	alpha-ribazole phosphatase activity
B1K54_RS05465	COG2124	cytochrome p450
B1K54_RS05470	COG0492	ferredoxin-NADP+ reductase activity
B1K54_RS05480	COG1132	(ABC) transporter
B1K54_RS05490	COG0277	FAD linked oxidase domain protein
B1K54_RS05495	COG1132	(ABC) transporter
B1K54_RS05500	COG1132	(ABC) transporter
B1K54_RS05520	COG1946	Acyl-CoA thioesterase
B1K54_RS05525	COG3012	SEC-C Motif Domain Protein
B1K54_RS05535	COG2018	Roadblock/LC7 domain
B1K54_RS05600	COG2814	Major facilitator Superfamily
B1K54_RS05625	COG1864	DNA RNA non-specific endonuclease
B1K54_RS05625	COG3591	Belongs to the peptidase S1B family
B1K54_RS05640	COG0596	Alpha beta hydrolase
B1K54_RS05645	COG2326	polyphosphate kinase activity
B1K54_RS05675	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B1K54_RS05690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B1K54_RS05700	COG3842	ATPase activity
B1K54_RS05720	COG2188	Transcriptional regulator
B1K54_RS05745	COG2957	Belongs to the agmatine deiminase family
B1K54_RS05755	COG2340	Cysteine-rich secretory protein family
B1K54_RS05780	COG0785	Cytochrome C biogenesis protein
B1K54_RS05790	COG0745	RESPONSE REGULATOR receiver
B1K54_RS05795	COG2205	protein histidine kinase activity
B1K54_RS05820	COG0693	protein deglycase activity
B1K54_RS05830	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B1K54_RS05855	COG1252	NADH dehydrogenase
B1K54_RS05865	COG2409	Drug exporters of the RND superfamily
B1K54_RS05870	COG3321	synthase
B1K54_RS05870	COG0604	alcohol dehydrogenase
B1K54_RS05890	COG2197	response regulator
B1K54_RS05890	COG3903	Transcriptional regulator
B1K54_RS05905	COG2409	Drug exporters of the RND superfamily
B1K54_RS05935	COG0702	epimerase
B1K54_RS05945	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B1K54_RS05970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1K54_RS06020	COG2814	Major facilitator Superfamily
B1K54_RS06025	COG1028	Short-chain dehydrogenase reductase Sdr
B1K54_RS06055	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B1K54_RS06070	COG1028	Short-chain dehydrogenase reductase Sdr
B1K54_RS06085	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B1K54_RS06090	COG1309	transcriptional regulator
B1K54_RS06100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1K54_RS06120	COG2824	Alkylphosphonate utilization operon protein PhnA
B1K54_RS06125	COG0318	PFAM AMP-dependent synthetase and ligase
B1K54_RS06150	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B1K54_RS06175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B1K54_RS06195	COG2319	Wd-40 repeat
B1K54_RS06195	COG4249	Peptidase C14 caspase catalytic subunit p20
B1K54_RS06205	COG2124	cytochrome p450
B1K54_RS06210	COG0156	8-amino-7-oxononanoate synthase activity
B1K54_RS06215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B1K54_RS06220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B1K54_RS06225	COG2814	Major facilitator Superfamily
B1K54_RS06230	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B1K54_RS06235	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B1K54_RS06235	COG0512	Glutamine amidotransferase of anthranilate synthase
B1K54_RS06250	COG1605	Chorismate mutase
B1K54_RS06260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1K54_RS06265	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B1K54_RS06275	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B1K54_RS06280	COG0473	3-isopropylmalate dehydrogenase activity
B1K54_RS06285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B1K54_RS06310	COG0318	PFAM AMP-dependent synthetase and ligase
B1K54_RS06315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B1K54_RS06320	COG0300	oxidoreductase activity
B1K54_RS06325	COG2814	Major facilitator Superfamily
B1K54_RS06345	COG1124	(ABC) transporter
B1K54_RS06350	COG0444	Belongs to the ABC transporter superfamily
B1K54_RS06355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1K54_RS06360	COG0601	transmembrane transport
B1K54_RS06370	COG5297	Belongs to the glycosyl hydrolase family 6
B1K54_RS06370	COG4733	cellulase activity
B1K54_RS06395	COG1960	acyl-CoA dehydrogenase activity
B1K54_RS06405	COG0242	peptide deformylase activity
B1K54_RS06415	COG3442	glutamine amidotransferase
B1K54_RS06420	COG0205	6-phosphofructokinase activity
B1K54_RS06430	COG0204	Acyl-transferase
B1K54_RS06440	COG0829	nickel cation binding
B1K54_RS06445	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B1K54_RS06455	COG0804	urea catabolic process
B1K54_RS06460	COG0832	Belongs to the urease beta subunit family
B1K54_RS06465	COG0831	urea catabolic process
B1K54_RS06485	COG0156	8-amino-7-oxononanoate synthase activity
B1K54_RS06490	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B1K54_RS06495	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B1K54_RS06500	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B1K54_RS06505	COG0456	acetyltransferase
B1K54_RS06525	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B1K54_RS06545	COG4974	Belongs to the 'phage' integrase family
B1K54_RS06575	COG4585	Histidine kinase
B1K54_RS06580	COG2197	response regulator
B1K54_RS06585	COG1940	carbohydrate kinase activity
B1K54_RS06590	COG2188	Transcriptional regulator
B1K54_RS06620	COG1522	sequence-specific DNA binding
B1K54_RS06625	COG0419	ATPase involved in DNA repair
B1K54_RS06630	COG0420	3'-5' exonuclease activity
B1K54_RS06635	COG1739	Uncharacterized protein family UPF0029
B1K54_RS06640	COG1832	CoA-binding protein
B1K54_RS06660	COG0110	maltose O-acetyltransferase activity
B1K54_RS06705	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B1K54_RS06720	COG1968	undecaprenyl-diphosphatase activity
B1K54_RS06740	COG2318	DinB family
B1K54_RS06755	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B1K54_RS06760	COG0747	negative chemotaxis
B1K54_RS06785	COG4974	Belongs to the 'phage' integrase family
B1K54_RS06800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B1K54_RS06845	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
B1K54_RS06855	COG1111	helicase
B1K54_RS06855	COG1205	dead DEAH box helicase
B1K54_RS06860	COG2815	serine threonine protein kinase
B1K54_RS06860	COG0515	serine threonine protein kinase
B1K54_RS06870	COG2815	serine threonine protein kinase
B1K54_RS06870	COG0515	serine threonine protein kinase
B1K54_RS06910	COG0477	Major facilitator Superfamily
B1K54_RS06965	COG0697	spore germination
B1K54_RS06980	COG1695	Transcriptional regulator
B1K54_RS07015	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B1K54_RS07015	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B1K54_RS07025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B1K54_RS07065	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B1K54_RS07100	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B1K54_RS07110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1K54_RS07125	COG1051	belongs to the nudix hydrolase family
B1K54_RS07130	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
B1K54_RS07145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B1K54_RS07160	COG2018	Roadblock/LC7 domain
B1K54_RS07190	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B1K54_RS07195	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B1K54_RS07200	COG1984	allophanate hydrolase subunit 2
B1K54_RS07245	COG2270	Major facilitator Superfamily
B1K54_RS07255	COG3030	protein affecting phage T7 exclusion by the F plasmid
B1K54_RS07260	COG0463	Glycosyl transferase, family 2
B1K54_RS07300	COG1960	acyl-CoA dehydrogenase activity
B1K54_RS07320	COG0572	uridine kinase
B1K54_RS07345	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B1K54_RS07350	COG0140	phosphoribosyl-ATP diphosphatase activity
B1K54_RS07355	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B1K54_RS07360	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B1K54_RS07360	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B1K54_RS07365	COG3201	nicotinamide mononucleotide transporter
B1K54_RS07385	COG1595	DNA-templated transcription, initiation
B1K54_RS07410	COG1940	carbohydrate kinase activity
B1K54_RS07410	COG1846	Transcriptional regulator
B1K54_RS07415	COG0738	Major facilitator superfamily
B1K54_RS07420	COG2233	PERMEase
B1K54_RS07440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1K54_RS07460	COG0531	amino acid
B1K54_RS07465	COG2755	lipolytic protein G-D-S-L family
B1K54_RS07485	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B1K54_RS07490	COG3275	phosphorelay sensor kinase activity
B1K54_RS07515	COG3548	integral membrane protein
B1K54_RS07555	COG1012	belongs to the aldehyde dehydrogenase family
B1K54_RS07570	COG2770	Histidine kinase
B1K54_RS07570	COG2208	phosphoserine phosphatase activity
B1K54_RS07590	COG1366	Belongs to the anti-sigma-factor antagonist family
B1K54_RS07630	COG0028	Belongs to the TPP enzyme family
B1K54_RS07645	COG0492	ferredoxin-NADP+ reductase activity
B1K54_RS07680	COG2390	Transcriptional regulator
B1K54_RS07685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B1K54_RS07710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B1K54_RS07725	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B1K54_RS07740	COG0194	GDP metabolic process
B1K54_RS07750	COG0284	orotidine-5'-phosphate decarboxylase activity
B1K54_RS07755	COG0167	dihydroorotate dehydrogenase activity
B1K54_RS07760	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B1K54_RS07765	COG0505	Belongs to the CarA family
B1K54_RS07775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B1K54_RS07780	COG0540	Belongs to the ATCase OTCase family
B1K54_RS07785	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B1K54_RS07795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B1K54_RS07800	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B1K54_RS07805	COG0006	proline dipeptidase activity
B1K54_RS07815	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B1K54_RS07820	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B1K54_RS07825	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B1K54_RS07830	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B1K54_RS07840	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B1K54_RS07855	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B1K54_RS07860	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B1K54_RS07880	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B1K54_RS07905	COG0124	histidyl-tRNA synthetase
B1K54_RS07915	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B1K54_RS07920	COG1196	nuclear chromosome segregation
B1K54_RS07925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B1K54_RS07930	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B1K54_RS07935	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1K54_RS07940	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1K54_RS07950	COG2255	four-way junction helicase activity
B1K54_RS07955	COG0632	four-way junction helicase activity
B1K54_RS07960	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B1K54_RS07965	COG0217	transcriptional regulatory protein
B1K54_RS07970	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B1K54_RS07975	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B1K54_RS07985	COG0438	transferase activity, transferring glycosyl groups
B1K54_RS07990	COG1560	Kdo2-lipid A biosynthetic process
B1K54_RS07995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B1K54_RS08020	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B1K54_RS08045	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B1K54_RS08100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B1K54_RS08105	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B1K54_RS08150	COG1648	precorrin-2 dehydrogenase activity
B1K54_RS08150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B1K54_RS08155	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B1K54_RS08170	COG1464	Belongs to the NlpA lipoprotein family
B1K54_RS08175	COG2011	ABC-type metal ion transport system permease component
B1K54_RS08180	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B1K54_RS08210	COG0318	PFAM AMP-dependent synthetase and ligase
B1K54_RS08210	COG0204	Acyl-transferase
B1K54_RS08225	COG0477	Major facilitator Superfamily
B1K54_RS08245	COG0165	Argininosuccinate lyase
B1K54_RS08250	COG0137	argininosuccinate synthase activity
B1K54_RS08275	COG1438	arginine binding
B1K54_RS08280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B1K54_RS08285	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B1K54_RS08290	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B1K54_RS08295	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B1K54_RS08310	COG0697	spore germination
B1K54_RS08320	COG1649	PFAM Uncharacterised BCR, COG1649
B1K54_RS08345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1K54_RS08345	COG0072	phenylalanine-tRNA ligase activity
B1K54_RS08350	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B1K54_RS08355	COG5002	protein histidine kinase activity
B1K54_RS08360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B1K54_RS08365	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B1K54_RS08370	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B1K54_RS08375	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B1K54_RS08410	COG1028	Short-chain dehydrogenase reductase Sdr
B1K54_RS08415	COG1012	belongs to the aldehyde dehydrogenase family
B1K54_RS08420	COG0174	glutamine synthetase
B1K54_RS08430	COG1113	amino acid transport
B1K54_RS08435	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B1K54_RS08465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B1K54_RS08475	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B1K54_RS08480	COG0564	pseudouridine synthase activity
B1K54_RS08490	COG0805	protein transport
B1K54_RS08495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1K54_RS08530	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B1K54_RS08540	COG1609	Transcriptional regulator
B1K54_RS08545	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B1K54_RS08550	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B1K54_RS08565	COG4122	O-methyltransferase activity
B1K54_RS08570	COG1222	aaa ATPase
B1K54_RS08590	COG1994	Peptidase M50
B1K54_RS08590	COG0517	IMP dehydrogenase activity
B1K54_RS08600	COG2197	response regulator
B1K54_RS08610	COG4166	transmembrane transport
B1K54_RS08620	COG1410	methionine synthase
B1K54_RS08620	COG0646	methionine synthase
B1K54_RS08625	COG1414	Transcriptional regulator
B1K54_RS08630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B1K54_RS08635	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B1K54_RS08640	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B1K54_RS08650	COG0215	cysteine-tRNA ligase activity
B1K54_RS08670	COG0598	Magnesium transport protein CorA
B1K54_RS08680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1K54_RS08685	COG0667	Aldo Keto reductase
B1K54_RS08715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B1K54_RS08730	COG1113	amino acid transport
B1K54_RS08755	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B1K54_RS08760	COG2149	membrane
B1K54_RS08785	COG1960	acyl-CoA dehydrogenase activity
B1K54_RS08795	COG0318	PFAM AMP-dependent synthetase and ligase
B1K54_RS08805	COG3876	Protein conserved in bacteria
B1K54_RS08825	COG0789	Transcriptional regulator
B1K54_RS08845	COG1960	acyl-CoA dehydrogenase activity
B1K54_RS08865	COG2851	Citrate transporter
B1K54_RS08870	COG0243	molybdopterin cofactor binding
B1K54_RS08875	COG1309	transcriptional regulator
B1K54_RS08895	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B1K54_RS08900	COG2188	Transcriptional regulator
B1K54_RS08925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1K54_RS08935	COG2815	serine threonine protein kinase
B1K54_RS08935	COG0515	serine threonine protein kinase
B1K54_RS08940	COG2755	lipolytic protein G-D-S-L family
B1K54_RS08950	COG1725	Transcriptional regulator
B1K54_RS08970	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B1K54_RS08975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B1K54_RS08980	COG0587	DNA-directed DNA polymerase activity
B1K54_RS09000	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B1K54_RS09015	COG0641	radical SAM
B1K54_RS09055	COG1799	cell septum assembly
B1K54_RS09060	COG1960	acyl-CoA dehydrogenase activity
B1K54_RS09070	COG0477	Major facilitator Superfamily
B1K54_RS09080	COG0671	phosphoesterase, PA-phosphatase related
B1K54_RS09090	COG3583	domain protein
B1K54_RS09105	COG1160	GTP binding
B1K54_RS09115	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B1K54_RS09140	COG1397	ADP-ribosylglycohydrolase
B1K54_RS09160	COG1187	pseudouridine synthase activity
B1K54_RS09165	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B1K54_RS09170	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B1K54_RS09185	COG0686	Belongs to the AlaDH PNT family
B1K54_RS09195	COG0494	nUDIX hydrolase
B1K54_RS09200	COG0504	CTP synthase activity
B1K54_RS09205	COG3387	PFAM Glycoside hydrolase 15-related
B1K54_RS09225	COG0497	DNA recombination
B1K54_RS09230	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B1K54_RS09250	COG1120	ATPase activity
B1K54_RS09255	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1K54_RS09260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1K54_RS09265	COG0647	UMP catabolic process
B1K54_RS09300	COG2094	Belongs to the DNA glycosylase MPG family
B1K54_RS09310	COG1881	PFAM PEBP family protein
B1K54_RS09335	COG1119	ATPase activity
B1K54_RS09360	COG2197	response regulator
B1K54_RS09365	COG4585	Histidine kinase
B1K54_RS09370	COG4221	oxidoreductase activity
B1K54_RS09375	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B1K54_RS09385	COG1716	ATPase activity
B1K54_RS09385	COG1131	(ABC) transporter
B1K54_RS09385	COG0842	Transport permease protein
B1K54_RS09395	COG0560	Phosphoserine phosphatase
B1K54_RS09395	COG3830	Belongs to the UPF0237 family
B1K54_RS09415	COG2186	Transcriptional regulator
B1K54_RS09425	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B1K54_RS09430	COG1028	Short-chain dehydrogenase reductase Sdr
B1K54_RS09445	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B1K54_RS09465	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B1K54_RS09470	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B1K54_RS09485	COG1063	alcohol dehydrogenase
B1K54_RS09525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B1K54_RS09570	COG1024	Enoyl-CoA hydratase
B1K54_RS09580	COG0488	(ABC) transporter
B1K54_RS09615	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B1K54_RS09620	COG1492	cobalamin metabolic process
B1K54_RS09640	COG1797	cobyrinic acid a,c-diamide synthase activity
B1K54_RS09670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B1K54_RS09685	COG0768	penicillin binding
B1K54_RS09690	COG2197	response regulator
B1K54_RS09695	COG4585	Histidine kinase
B1K54_RS09745	COG2171	N-acyltransferase activity
B1K54_RS09760	COG3226	Transcriptional regulator
B1K54_RS09765	COG2076	Multidrug Resistance protein
B1K54_RS09775	COG0822	iron-sulfur transferase activity
B1K54_RS09780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B1K54_RS09785	COG0396	ATPase activity
B1K54_RS09795	COG0719	Fe-S assembly protein
B1K54_RS09825	COG1612	heme a metabolic process
B1K54_RS09840	COG0109	protoheme IX farnesyltransferase activity
B1K54_RS09850	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B1K54_RS09865	COG0363	glucosamine-6-phosphate deaminase activity
B1K54_RS09870	COG0166	Belongs to the GPI family
B1K54_RS09880	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B1K54_RS09885	COG0149	triose-phosphate isomerase activity
B1K54_RS09890	COG0126	phosphoglycerate kinase activity
B1K54_RS09895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B1K54_RS09905	COG1481	regulation of sporulation
B1K54_RS09915	COG1660	Displays ATPase and GTPase activities
B1K54_RS09920	COG0322	excinuclease ABC activity
B1K54_RS09950	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B1K54_RS09960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1K54_RS09965	COG0477	Major facilitator Superfamily
B1K54_RS09985	COG0556	nucleotide-excision repair
B1K54_RS09990	COG0584	glycerophosphoryl diester phosphodiesterase
B1K54_RS09995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B1K54_RS10010	COG2226	methyltransferase
B1K54_RS10015	COG2313	pseudouridylate synthase activity
B1K54_RS10055	COG4279	zinc finger
B1K54_RS10060	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B1K54_RS10090	COG0237	dephospho-CoA kinase activity
B1K54_RS10105	COG2226	methyltransferase
B1K54_RS10110	COG1643	Atp-dependent helicase
B1K54_RS10140	COG2050	protein possibly involved in aromatic compounds catabolism
B1K54_RS10155	COG0559	Belongs to the binding-protein-dependent transport system permease family
B1K54_RS10210	COG0737	Belongs to the 5'-nucleotidase family
B1K54_RS10235	COG0287	Prephenate dehydrogenase
B1K54_RS10235	COG1605	Chorismate mutase
B1K54_RS10270	COG0277	FAD linked oxidase domain protein
B1K54_RS10280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B1K54_RS10290	COG1309	transcriptional regulator
B1K54_RS10300	COG1028	Short-chain dehydrogenase reductase Sdr
B1K54_RS10310	COG1113	amino acid transport
B1K54_RS10320	COG1028	Short-chain dehydrogenase reductase Sdr
B1K54_RS10330	COG1024	Enoyl-CoA hydratase
B1K54_RS10350	COG2365	Tyrosine phosphatase family
B1K54_RS10355	COG0513	Belongs to the DEAD box helicase family
B1K54_RS10360	COG1278	Cold shock
B1K54_RS10365	COG0183	Belongs to the thiolase family
B1K54_RS10370	COG1309	transcriptional regulator
B1K54_RS10380	COG1960	acyl-CoA dehydrogenase activity
B1K54_RS10385	COG1960	acyl-CoA dehydrogenase activity
B1K54_RS10450	COG0070	glutamate synthase
B1K54_RS10450	COG0069	glutamate synthase activity
B1K54_RS10450	COG0067	glutamate synthase
B1K54_RS10470	COG1397	ADP-ribosylglycohydrolase
B1K54_RS10480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B1K54_RS10485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1K54_RS10495	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B1K54_RS10505	COG0159	tryptophan synthase activity
B1K54_RS10510	COG0133	tryptophan synthase activity
B1K54_RS10520	COG0134	indole-3-glycerol-phosphate synthase activity
B1K54_RS10545	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B1K54_RS10555	COG0107	imidazoleglycerol-phosphate synthase activity
B1K54_RS10560	COG0251	oxidation-reduction process
B1K54_RS10565	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B1K54_RS10570	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B1K54_RS10575	COG0131	Imidazoleglycerol-phosphate dehydratase
B1K54_RS10580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B1K54_RS10585	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B1K54_RS10600	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B1K54_RS10620	COG1432	Conserved Protein
B1K54_RS10625	COG0587	DNA-directed DNA polymerase activity
B1K54_RS10680	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B1K54_RS10690	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B1K54_RS10705	COG1799	cell septum assembly
B1K54_RS10730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B1K54_RS10735	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B1K54_RS10745	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B1K54_RS10750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B1K54_RS10760	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B1K54_RS10775	COG0275	rRNA processing
B1K54_RS10785	COG0714	Associated with various cellular activities
B1K54_RS10805	COG1309	transcriptional regulator
B1K54_RS10815	COG1131	(ABC) transporter
B1K54_RS10840	COG1233	COG1233 Phytoene dehydrogenase and related
B1K54_RS10855	COG0352	thiamine-phosphate diphosphorylase activity
B1K54_RS10870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1K54_RS10870	COG2022	thiamine diphosphate biosynthetic process
B1K54_RS10875	COG2104	thiamine diphosphate biosynthetic process
B1K54_RS10880	COG2022	thiamine diphosphate biosynthetic process
B1K54_RS10885	COG0515	serine threonine protein kinase
B1K54_RS10885	COG2815	serine threonine protein kinase
B1K54_RS10890	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B1K54_RS10895	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B1K54_RS10900	COG2193	ferroxidase activity
B1K54_RS10910	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B1K54_RS10925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B1K54_RS10930	COG0205	6-phosphofructokinase activity
B1K54_RS10935	COG2197	response regulator
B1K54_RS10940	COG4585	Histidine kinase
B1K54_RS10965	COG1940	carbohydrate kinase activity
B1K54_RS10975	COG0003	Pfam Anion-transporting ATPase
B1K54_RS11000	COG0438	transferase activity, transferring glycosyl groups
B1K54_RS11040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B1K54_RS11045	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B1K54_RS11050	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B1K54_RS11055	COG0723	plastoquinol--plastocyanin reductase activity
B1K54_RS11060	COG2010	Cytochrome c
B1K54_RS11065	COG1845	cytochrome c oxidase, subunit III
B1K54_RS11075	COG1376	ErfK ybiS ycfS ynhG family protein
B1K54_RS11085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B1K54_RS11090	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B1K54_RS11095	COG1104	cysteine desulfurase activity
B1K54_RS11100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B1K54_RS11120	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B1K54_RS11125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B1K54_RS11130	COG2197	response regulator
B1K54_RS11135	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B1K54_RS11160	COG2226	methyltransferase
B1K54_RS11175	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B1K54_RS11180	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B1K54_RS11180	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B1K54_RS11210	COG0438	transferase activity, transferring glycosyl groups
B1K54_RS11220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B1K54_RS11225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B1K54_RS11230	COG0508	dehydrogenase complex catalyzes the overall conversion of
B1K54_RS11240	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B1K54_RS11245	COG2815	serine threonine protein kinase
B1K54_RS11245	COG0515	serine threonine protein kinase
B1K54_RS11255	COG1028	Short-chain dehydrogenase reductase Sdr
B1K54_RS11290	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B1K54_RS11295	COG0321	lipoyl(octanoyl) transferase activity
B1K54_RS11345	COG1846	Transcriptional regulator
B1K54_RS11355	COG0673	inositol 2-dehydrogenase activity
B1K54_RS11365	COG0745	RESPONSE REGULATOR receiver
B1K54_RS11385	COG2365	Tyrosine phosphatase family
B1K54_RS11445	COG0366	Alpha amylase catalytic
B1K54_RS11455	COG1175	transmembrane transport
B1K54_RS11465	COG0366	Alpha amylase catalytic
B1K54_RS11475	COG1609	Transcriptional regulator
B1K54_RS11490	COG3511	phospholipase C
B1K54_RS11525	COG2340	Cysteine-rich secretory protein family
B1K54_RS11550	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B1K54_RS11580	COG0174	glutamine synthetase
B1K54_RS11620	COG2132	Multicopper oxidase
B1K54_RS11630	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B1K54_RS11630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1K54_RS11640	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B1K54_RS11660	COG1994	Peptidase M50
B1K54_RS11695	COG5398	heme oxygenase
B1K54_RS11715	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B1K54_RS11720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1K54_RS11725	COG1120	ATPase activity
B1K54_RS11735	COG0384	phenazine biosynthesis protein PhzF
B1K54_RS11745	COG2814	Major facilitator Superfamily
B1K54_RS11755	COG1834	amidinotransferase
B1K54_RS11770	COG3022	response to hydroperoxide
B1K54_RS11800	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B1K54_RS11810	COG1028	Short-chain dehydrogenase reductase Sdr
B1K54_RS11820	COG2030	dehydratase
B1K54_RS11825	COG2197	response regulator
B1K54_RS11830	COG1595	DNA-templated transcription, initiation
B1K54_RS11850	COG0183	Belongs to the thiolase family
B1K54_RS11855	COG1960	acyl-CoA dehydrogenase activity
B1K54_RS11860	COG0515	serine threonine protein kinase
B1K54_RS11860	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B1K54_RS11875	COG0515	serine threonine protein kinase
B1K54_RS11875	COG2815	serine threonine protein kinase
B1K54_RS11885	COG0860	N-Acetylmuramoyl-L-alanine amidase
B1K54_RS11900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1K54_RS11935	COG0297	glycogen (starch) synthase activity
B1K54_RS11940	COG1309	transcriptional regulator
B1K54_RS11965	COG1960	acyl-CoA dehydrogenase activity
B1K54_RS11980	COG2175	clavaminate synthase activity
B1K54_RS12005	COG1657	PFAM Prenyltransferase squalene oxidase
B1K54_RS12020	COG3845	ABC transporter
B1K54_RS12035	COG0183	Belongs to the thiolase family
B1K54_RS12040	COG2124	cytochrome p450
B1K54_RS12080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B1K54_RS12085	COG2318	DinB family
B1K54_RS12125	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B1K54_RS12180	COG1358	cellular component organization or biogenesis
B1K54_RS12230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1K54_RS12240	COG1309	transcriptional regulator
B1K54_RS12255	COG0667	Aldo Keto reductase
B1K54_RS12260	COG0789	Transcriptional regulator
B1K54_RS12290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B1K54_RS12295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B1K54_RS12300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B1K54_RS12320	COG1309	transcriptional regulator
B1K54_RS12330	COG2084	Dehydrogenase
B1K54_RS12335	COG0583	DNA-binding transcription factor activity
B1K54_RS12355	COG1733	regulation of RNA biosynthetic process
B1K54_RS12370	COG1764	response to oxidative stress
B1K54_RS12375	COG2130	NADP-dependent
B1K54_RS12395	COG2205	protein histidine kinase activity
B1K54_RS12400	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B1K54_RS12405	COG1077	Cell shape determining protein MreB Mrl
B1K54_RS12415	COG1522	sequence-specific DNA binding
B1K54_RS12430	COG0825	malonyl-CoA metabolic process
B1K54_RS12430	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B1K54_RS12440	COG0662	Cupin 2, conserved barrel domain protein
B1K54_RS12445	COG0477	Major facilitator Superfamily
B1K54_RS12450	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B1K54_RS12520	COG1070	Carbohydrate kinase
B1K54_RS12555	COG0243	molybdopterin cofactor binding
B1K54_RS12565	COG2949	membrane
B1K54_RS12575	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B1K54_RS12585	COG0358	DNA primase activity
B1K54_RS12620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B1K54_RS12625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B1K54_RS12625	COG2146	nitrite reductase [NAD(P)H] activity
B1K54_RS12655	COG0574	Belongs to the PEP-utilizing enzyme family
B1K54_RS12655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B1K54_RS12665	COG0477	Major facilitator Superfamily
B1K54_RS12670	COG1846	Transcriptional regulator
B1K54_RS12680	COG0667	Aldo Keto reductase
B1K54_RS12685	COG1309	transcriptional regulator
B1K54_RS12690	COG0423	glycine-tRNA ligase activity
B1K54_RS12695	COG3443	Belongs to the bacterial solute-binding protein 9 family
B1K54_RS12695	COG0803	Belongs to the bacterial solute-binding protein 9 family
B1K54_RS12700	COG1121	(ABC) transporter
B1K54_RS12705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B1K54_RS12720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B1K54_RS12725	COG1381	Involved in DNA repair and RecF pathway recombination
B1K54_RS12730	COG2233	PERMEase
B1K54_RS12740	COG0300	oxidoreductase activity
B1K54_RS12745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1K54_RS12770	COG2813	Specifically methylates the guanine in position
B1K54_RS12775	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B1K54_RS12790	COG2315	Protein conserved in bacteria
B1K54_RS12800	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B1K54_RS12810	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B1K54_RS12810	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B1K54_RS12815	COG1234	tRNA 3'-trailer cleavage
B1K54_RS12820	COG0537	adenosine 5'-monophosphoramidase activity
B1K54_RS12835	COG0484	heat shock protein binding
B1K54_RS12840	COG1420	regulation of RNA biosynthetic process
B1K54_RS12865	COG0481	GTPase activity
B1K54_RS12870	COG0268	Binds directly to 16S ribosomal RNA
B1K54_RS12885	COG2353	YceI-like domain
B1K54_RS12895	COG1555	photosystem II stabilization
B1K54_RS12895	COG1596	polysaccharide export
B1K54_RS12900	COG1307	EDD domain protein, DegV family
B1K54_RS12910	COG0495	leucyl-tRNA aminoacylation
B1K54_RS12930	COG0588	phosphoglycerate mutase activity
B1K54_RS12935	COG0799	negative regulation of ribosome biogenesis
B1K54_RS12945	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B1K54_RS12950	COG0501	Belongs to the peptidase M48B family
B1K54_RS12965	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B1K54_RS12975	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B1K54_RS12985	COG0463	Glycosyl transferase, family 2
B1K54_RS12990	COG0463	Glycosyl transferase, family 2
B1K54_RS12990	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B1K54_RS12995	COG0438	transferase activity, transferring glycosyl groups
B1K54_RS13005	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B1K54_RS13005	COG1215	transferase activity, transferring glycosyl groups
B1K54_RS13010	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B1K54_RS13015	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B1K54_RS13020	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B1K54_RS13025	COG1530	ribonuclease E activity
B1K54_RS13055	COG0772	Belongs to the SEDS family
B1K54_RS13060	COG0768	penicillin binding
B1K54_RS13075	COG1077	Cell shape determining protein MreB Mrl
B1K54_RS13080	COG0105	UTP biosynthetic process
B1K54_RS13090	COG0285	dihydrofolate synthase activity
B1K54_RS13095	COG1077	Cell shape determining protein MreB Mrl
B1K54_RS13100	COG4585	Histidine kinase
B1K54_RS13105	COG0525	valine-tRNA ligase activity
B1K54_RS13115	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B1K54_RS13120	COG0740	serine-type endopeptidase activity
B1K54_RS13125	COG0740	serine-type endopeptidase activity
B1K54_RS13130	COG0544	peptidyl-prolyl cis-trans isomerase activity
B1K54_RS13190	COG2188	Transcriptional regulator
B1K54_RS13210	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B1K54_RS13220	COG2186	Transcriptional regulator
B1K54_RS13300	COG1113	amino acid transport
B1K54_RS13310	COG1113	amino acid transport
B1K54_RS13315	COG1113	amino acid transport
B1K54_RS13320	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B1K54_RS13325	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B1K54_RS13375	COG0583	DNA-binding transcription factor activity
B1K54_RS13385	COG0697	spore germination
B1K54_RS13410	COG3525	Glycosyl hydrolase, family 20, catalytic domain
B1K54_RS13410	COG3291	Pkd domain containing protein
B1K54_RS13420	COG0668	transmembrane transport
B1K54_RS13435	COG1175	transmembrane transport
B1K54_RS13440	COG0395	ABC-type sugar transport system, permease component
B1K54_RS13445	COG1486	melibiose metabolic process
B1K54_RS13460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1K54_RS13495	COG2346	COG2346, Truncated hemoglobins
B1K54_RS13535	COG0629	single-stranded DNA binding
B1K54_RS13540	COG1116	anion transmembrane transporter activity
B1K54_RS13560	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B1K54_RS13610	COG3962	Belongs to the TPP enzyme family
B1K54_RS13615	COG3718	enzyme involved in inositol metabolism
B1K54_RS13620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B1K54_RS13625	COG1082	Xylose isomerase domain protein TIM barrel
B1K54_RS13630	COG0673	inositol 2-dehydrogenase activity
B1K54_RS13655	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B1K54_RS13675	COG1472	Belongs to the glycosyl hydrolase 3 family
B1K54_RS13710	COG0028	Belongs to the TPP enzyme family
B1K54_RS13735	COG1946	Acyl-CoA thioesterase
B1K54_RS13740	COG0463	Glycosyl transferase, family 2
B1K54_RS13760	COG3209	COG3209 Rhs family protein
B1K54_RS13775	COG1309	transcriptional regulator
B1K54_RS13780	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B1K54_RS13795	COG1960	acyl-CoA dehydrogenase activity
B1K54_RS13810	COG0076	glutamate decarboxylase activity
B1K54_RS13815	COG3486	L-lysine 6-monooxygenase (NADPH) activity
B1K54_RS13825	COG4264	IucA IucC family
B1K54_RS13845	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B1K54_RS13855	COG0589	response to stress
B1K54_RS13865	COG4977	sequence-specific DNA binding
B1K54_RS13870	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B1K54_RS13895	COG0395	ABC-type sugar transport system, permease component
B1K54_RS13930	COG0745	RESPONSE REGULATOR receiver
B1K54_RS13960	COG0406	alpha-ribazole phosphatase activity
B1K54_RS14040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1K54_RS14055	COG0318	PFAM AMP-dependent synthetase and ligase
B1K54_RS14060	COG3397	chitin binding
B1K54_RS14130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1K54_RS14135	COG2188	Transcriptional regulator
B1K54_RS14150	COG0673	inositol 2-dehydrogenase activity
B1K54_RS14165	COG0706	membrane insertase activity
B1K54_RS14175	COG3764	Sortase (surface protein transpeptidase)
B1K54_RS14215	COG2733	membrane
B1K54_RS14225	COG4555	ABC transporter
B1K54_RS14240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B1K54_RS14280	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B1K54_RS14290	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B1K54_RS14295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B1K54_RS14300	COG1263	PTS System
B1K54_RS14305	COG1263	PTS System
B1K54_RS14310	COG1234	tRNA 3'-trailer cleavage
B1K54_RS14340	COG1113	amino acid transport
B1K54_RS14350	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B1K54_RS14360	COG1335	isochorismatase
B1K54_RS14395	COG0277	FAD linked oxidase domain protein
B1K54_RS14405	COG3185	4-Hydroxyphenylpyruvate dioxygenase
B1K54_RS14435	COG3654	unkown
B1K54_RS14465	COG1404	Belongs to the peptidase S8 family
B1K54_RS14485	COG2080	2 iron, 2 sulfur cluster binding
B1K54_RS14495	COG3525	Glycosyl hydrolase, family 20, catalytic domain
B1K54_RS14505	COG1678	Uncharacterized ACR, COG1678
B1K54_RS14510	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B1K54_RS14515	COG0776	regulation of translation
B1K54_RS14525	COG3973	AAA domain
B1K54_RS14545	COG2223	nitrite transmembrane transporter activity
B1K54_RS14550	COG0583	DNA-binding transcription factor activity
B1K54_RS14590	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B1K54_RS14595	COG0793	Belongs to the peptidase S41A family
B1K54_RS14605	COG2884	Cell division ATP-binding protein ftsE
B1K54_RS14615	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B1K54_RS14625	COG0515	serine threonine protein kinase
B1K54_RS14630	COG0515	serine threonine protein kinase
B1K54_RS14645	COG1175	transmembrane transport
B1K54_RS14650	COG0395	ABC-type sugar transport system, permease component
B1K54_RS14655	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B1K54_RS14670	COG1388	LysM domain
B1K54_RS14670	COG1134	teichoic acid transport
B1K54_RS14680	COG0546	phosphoglycolate phosphatase activity
B1K54_RS14695	COG0653	protein targeting
B1K54_RS14710	COG2197	response regulator
B1K54_RS14715	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B1K54_RS14725	COG0823	Involved in the tonB-independent uptake of proteins
B1K54_RS14730	COG5000	phosphorelay sensor kinase activity
B1K54_RS14730	COG5002	protein histidine kinase activity
B1K54_RS14735	COG0745	RESPONSE REGULATOR receiver
B1K54_RS14755	COG0714	Associated with various cellular activities
B1K54_RS14805	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B1K54_RS14820	COG1482	cell wall glycoprotein biosynthetic process
B1K54_RS14830	COG2835	tetraacyldisaccharide 4'-kinase activity
B1K54_RS14835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1K54_RS14875	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B1K54_RS14880	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
B1K54_RS14880	COG0778	Nitroreductase
B1K54_RS14900	COG1316	TRANSCRIPTIONal
B1K54_RS14905	COG1316	TRANSCRIPTIONal
B1K54_RS14925	COG1607	acyl-coa hydrolase
B1K54_RS14930	COG1316	TRANSCRIPTIONal
B1K54_RS14945	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B1K54_RS14975	COG2205	protein histidine kinase activity
B1K54_RS14980	COG0745	RESPONSE REGULATOR receiver
B1K54_RS14985	COG3104	oligopeptide transport
B1K54_RS15010	COG1228	amidohydrolase
B1K54_RS15025	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B1K54_RS15030	COG0019	diaminopimelate decarboxylase activity
B1K54_RS15060	COG2755	lipolytic protein G-D-S-L family
B1K54_RS15065	COG0183	Belongs to the thiolase family
B1K54_RS15095	COG1136	(ABC) transporter
B1K54_RS15100	COG0577	efflux transmembrane transporter activity
B1K54_RS15105	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B1K54_RS15110	COG1252	NADH dehydrogenase
B1K54_RS15130	COG0148	phosphopyruvate hydratase activity
B1K54_RS15145	COG2124	cytochrome p450
B1K54_RS15150	COG1017	nitric oxide dioxygenase activity
B1K54_RS15150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B1K54_RS15170	COG0515	serine threonine protein kinase
B1K54_RS15170	COG2815	serine threonine protein kinase
B1K54_RS15190	COG0577	efflux transmembrane transporter activity
B1K54_RS15195	COG1136	(ABC) transporter
B1K54_RS15200	COG2814	Major facilitator Superfamily
B1K54_RS15240	COG4585	Histidine kinase
B1K54_RS15255	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B1K54_RS15260	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B1K54_RS15265	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B1K54_RS15270	COG0193	aminoacyl-tRNA hydrolase activity
B1K54_RS15280	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B1K54_RS15290	COG1309	transcriptional regulator
B1K54_RS15300	COG4106	trans-aconitate 2-methyltransferase activity
B1K54_RS15305	COG1846	Transcriptional regulator
B1K54_RS15310	COG2197	response regulator
B1K54_RS15335	COG0488	(ABC) transporter
B1K54_RS15345	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B1K54_RS15350	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B1K54_RS15355	COG3584	3D domain protein
B1K54_RS15355	COG3583	domain protein
B1K54_RS15360	COG0084	hydrolase, TatD family'
B1K54_RS15395	COG0442	prolyl-tRNA aminoacylation
B1K54_RS15400	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B1K54_RS15405	COG1122	ATPase activity
B1K54_RS15415	COG0310	cobalt ion transport
B1K54_RS15425	COG2409	Drug exporters of the RND superfamily
B1K54_RS15435	COG0793	Belongs to the peptidase S41A family
B1K54_RS15435	COG4946	Tricorn protease homolog
B1K54_RS15445	COG2072	flavoprotein involved in K transport
B1K54_RS15455	COG0708	Exodeoxyribonuclease III
B1K54_RS15465	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1K54_RS15505	COG0521	Mo-molybdopterin cofactor biosynthetic process
B1K54_RS15505	COG0315	cyclic pyranopterin monophosphate synthase activity
B1K54_RS15510	COG0315	cyclic pyranopterin monophosphate synthase activity
B1K54_RS15520	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B1K54_RS15525	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B1K54_RS15535	COG3263	regulation of cellular component size
B1K54_RS15550	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B1K54_RS15565	COG1970	mechanosensitive ion channel activity
B1K54_RS15630	COG0492	ferredoxin-NADP+ reductase activity
B1K54_RS15655	COG0438	transferase activity, transferring glycosyl groups
B1K54_RS15675	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B1K54_RS15680	COG0438	transferase activity, transferring glycosyl groups
B1K54_RS15740	COG0477	Major facilitator Superfamily
B1K54_RS15755	COG3384	dioxygenase
B1K54_RS15780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B1K54_RS15820	COG2205	protein histidine kinase activity
B1K54_RS15835	COG1686	Belongs to the peptidase S11 family
B1K54_RS15875	COG1597	lipid kinase activity
B1K54_RS15885	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B1K54_RS15890	COG2365	Tyrosine phosphatase family
B1K54_RS15935	COG0346	lactoylglutathione lyase activity
B1K54_RS15950	COG1396	sequence-specific DNA binding
B1K54_RS15960	COG4335	DNA alkylation repair
B1K54_RS16000	COG0494	nUDIX hydrolase
B1K54_RS16080	COG1024	Enoyl-CoA hydratase
B1K54_RS16095	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B1K54_RS16095	COG0515	serine threonine protein kinase
B1K54_RS16105	COG1309	transcriptional regulator
B1K54_RS16115	COG1960	acyl-CoA dehydrogenase activity
B1K54_RS16135	COG0259	pyridoxamine-phosphate oxidase activity
B1K54_RS16150	COG2072	flavoprotein involved in K transport
B1K54_RS16165	COG1024	Enoyl-CoA hydratase
B1K54_RS16175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B1K54_RS16185	COG1960	acyl-CoA dehydrogenase activity
B1K54_RS16190	COG1028	Short-chain dehydrogenase reductase Sdr
B1K54_RS16210	COG1960	acyl-CoA dehydrogenase activity
B1K54_RS16215	COG1960	acyl-CoA dehydrogenase activity
B1K54_RS16225	COG0318	PFAM AMP-dependent synthetase and ligase
B1K54_RS16280	COG1131	(ABC) transporter
B1K54_RS16290	COG0596	Alpha beta hydrolase
B1K54_RS16290	COG2945	thiolester hydrolase activity
B1K54_RS16300	COG4821	SIS domain
B1K54_RS16310	COG0259	pyridoxamine-phosphate oxidase activity
B1K54_RS16340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B1K54_RS16365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B1K54_RS16390	COG3293	Transposase
B1K54_RS16420	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B1K54_RS16445	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B1K54_RS16455	COG2252	PERMEase
B1K54_RS16480	COG0739	heme binding
B1K54_RS16480	COG1196	nuclear chromosome segregation
B1K54_RS16480	COG0741	lytic transglycosylase activity
B1K54_RS16500	COG0667	Aldo Keto reductase
B1K54_RS16525	COG2814	Major facilitator Superfamily
B1K54_RS16535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B1K54_RS16540	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
B1K54_RS16545	COG1278	Cold shock
B1K54_RS16585	COG2197	response regulator
B1K54_RS16595	COG0515	serine threonine protein kinase
B1K54_RS16625	COG1454	alcohol dehydrogenase
B1K54_RS16630	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B1K54_RS16650	COG1215	transferase activity, transferring glycosyl groups
B1K54_RS16670	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
B1K54_RS16680	COG1061	Type III restriction enzyme res subunit
B1K54_RS16700	COG3973	AAA domain
B1K54_RS16775	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B1K54_RS16825	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B1K54_RS16825	COG0515	serine threonine protein kinase
B1K54_RS16835	COG0135	phosphoribosylanthranilate isomerase activity
B1K54_RS16850	COG0459	protein refolding
B1K54_RS16870	COG0463	Glycosyl transferase, family 2
B1K54_RS16875	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
B1K54_RS16880	COG0561	phosphatase activity
B1K54_RS16880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B1K54_RS16890	COG2182	Extracellular solute-binding protein
B1K54_RS16900	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B1K54_RS16925	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B1K54_RS16950	COG3290	protein histidine kinase activity
B1K54_RS16995	COG3842	ATPase activity
B1K54_RS17005	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B1K54_RS17020	COG0215	cysteine-tRNA ligase activity
B1K54_RS17025	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B1K54_RS17030	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B1K54_RS17035	COG1329	Transcriptional regulator
B1K54_RS17055	COG5002	protein histidine kinase activity
B1K54_RS17080	COG0588	phosphoglycerate mutase activity
B1K54_RS17100	COG0438	transferase activity, transferring glycosyl groups
B1K54_RS17135	COG2890	protein-(glutamine-N5) methyltransferase activity
B1K54_RS17140	COG4552	Acetyltransferase involved in intracellular survival and related
B1K54_RS17150	COG1490	D-aminoacyl-tRNA deacylase activity
B1K54_RS17165	COG3485	protocatechuate 3,4-dioxygenase
B1K54_RS17195	COG2897	thiosulfate sulfurtransferase activity
B1K54_RS17220	COG0745	RESPONSE REGULATOR receiver
B1K54_RS17225	COG1609	Transcriptional regulator
B1K54_RS17235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1K54_RS17240	COG0745	RESPONSE REGULATOR receiver
B1K54_RS17250	COG0823	Involved in the tonB-independent uptake of proteins
B1K54_RS17260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B1K54_RS17265	COG0737	Belongs to the 5'-nucleotidase family
B1K54_RS17270	COG0456	acetyltransferase
B1K54_RS17275	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B1K54_RS17305	COG0306	phosphate transporter
B1K54_RS17315	COG1937	Protein conserved in bacteria
B1K54_RS17340	COG0671	phosphoesterase, PA-phosphatase related
B1K54_RS17345	COG0739	heme binding
B1K54_RS17345	COG0741	lytic transglycosylase activity
B1K54_RS17345	COG1196	nuclear chromosome segregation
B1K54_RS17360	COG1280	lysine exporter protein (LysE YggA)
B1K54_RS17365	COG1357	PFAM Pentapeptide repeats (8 copies)
B1K54_RS17385	COG2945	thiolester hydrolase activity
B1K54_RS17385	COG0596	Alpha beta hydrolase
B1K54_RS17515	COG1252	NADH dehydrogenase
B1K54_RS17555	COG0579	oxidoreductase
B1K54_RS17560	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B1K54_RS17570	COG0739	heme binding
B1K54_RS17570	COG0741	lytic transglycosylase activity
B1K54_RS17570	COG1196	nuclear chromosome segregation
B1K54_RS17600	COG0513	Belongs to the DEAD box helicase family
B1K54_RS17610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B1K54_RS17615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B1K54_RS17640	COG0785	Cytochrome C biogenesis protein
B1K54_RS17655	COG1643	Atp-dependent helicase
B1K54_RS17685	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B1K54_RS17695	COG3119	arylsulfatase activity
B1K54_RS17715	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B1K54_RS17720	COG0047	phosphoribosylformylglycinamidine synthase activity
B1K54_RS17725	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B1K54_RS17745	COG1131	(ABC) transporter
B1K54_RS17755	COG3850	Histidine kinase
B1K54_RS17760	COG2197	response regulator
B1K54_RS17770	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B1K54_RS17785	COG0151	Belongs to the GarS family
B1K54_RS17865	COG0494	nUDIX hydrolase
B1K54_RS17875	COG0105	UTP biosynthetic process
B1K54_RS17955	COG0433	COG0433 Predicted ATPase
B1K54_RS17970	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B1K54_RS18010	COG1191	sigma factor activity
B1K54_RS18050	COG2205	protein histidine kinase activity
B1K54_RS18055	COG0745	RESPONSE REGULATOR receiver
B1K54_RS18115	COG0318	PFAM AMP-dependent synthetase and ligase
B1K54_RS18120	COG1595	DNA-templated transcription, initiation
B1K54_RS18135	COG1960	acyl-CoA dehydrogenase activity
B1K54_RS18145	COG1960	acyl-CoA dehydrogenase activity
B1K54_RS18175	COG2855	membrane
B1K54_RS18190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1K54_RS18205	COG0653	protein targeting
B1K54_RS18225	COG0006	proline dipeptidase activity
B1K54_RS18245	COG1999	signal sequence binding
B1K54_RS18255	COG2372	response to copper ion
B1K54_RS18260	COG2837	iron assimilation
B1K54_RS18270	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B1K54_RS18275	COG0561	phosphatase activity
B1K54_RS18300	COG1131	(ABC) transporter
B1K54_RS18315	COG0789	Transcriptional regulator
B1K54_RS18325	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
B1K54_RS18330	COG0326	Molecular chaperone. Has ATPase activity
B1K54_RS18345	COG0561	phosphatase activity
B1K54_RS18355	COG4988	ABC transporter
B1K54_RS18360	COG1294	oxidase, subunit
B1K54_RS18365	COG1271	oxidase subunit
B1K54_RS18375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B1K54_RS18380	COG1609	Transcriptional regulator
B1K54_RS18410	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B1K54_RS18435	COG0662	Cupin 2, conserved barrel domain protein
B1K54_RS18440	COG1950	PFAM Membrane protein of
B1K54_RS18445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B1K54_RS18450	COG0626	cystathionine gamma-synthase activity
B1K54_RS18480	COG0456	acetyltransferase
B1K54_RS18490	COG0305	Participates in initiation and elongation during chromosome replication
B1K54_RS18500	COG0359	binds to the 23S rRNA
B1K54_RS18505	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B1K54_RS18510	COG0629	single-stranded DNA binding
B1K54_RS18515	COG0360	Binds together with S18 to 16S ribosomal RNA
B1K54_RS18540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B1K54_RS18550	COG1260	myo-inositol-1-phosphate synthase
B1K54_RS18560	COG0617	tRNA 3'-terminal CCA addition
B1K54_RS18580	COG1595	DNA-templated transcription, initiation
B1K54_RS18590	COG0492	ferredoxin-NADP+ reductase activity
B1K54_RS18595	COG3118	belongs to the thioredoxin family
B1K54_RS18610	COG1192	Involved in chromosome partitioning
B1K54_RS18615	COG0357	Ribosomal RNA small subunit methyltransferase G
B1K54_RS18625	COG0706	membrane insertase activity
B1K54_RS18630	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B1K54_RS18635	COG0594	ribonuclease P activity
B1K54_RS18645	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B1K54_RS18655	COG0592	DNA-directed DNA polymerase activity
B1K54_RS18660	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B1K54_RS18665	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B1K54_RS18670	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
B1K54_RS18680	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B1K54_RS18705	COG0515	serine threonine protein kinase
B1K54_RS18735	COG0457	Tetratricopeptide repeat
B1K54_RS18735	COG0705	Rhomboid family
B1K54_RS18750	COG3764	Sortase (surface protein transpeptidase)
B1K54_RS18760	COG3764	Sortase (surface protein transpeptidase)
B1K54_RS18765	COG3764	Sortase (surface protein transpeptidase)
B1K54_RS18770	COG0515	serine threonine protein kinase
B1K54_RS18795	COG1716	ATPase activity
B1K54_RS18800	COG1716	ATPase activity
B1K54_RS18810	COG4585	Histidine kinase
B1K54_RS18815	COG2197	response regulator
B1K54_RS18840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B1K54_RS18845	COG2151	metal-sulfur cluster biosynthetic enzyme
B1K54_RS18850	COG3396	Phenylacetate-CoA oxygenase
B1K54_RS18855	COG3460	Phenylacetate-CoA oxygenase
B1K54_RS18860	COG3396	Phenylacetate-CoA oxygenase
B1K54_RS18890	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1K54_RS18895	COG1309	transcriptional regulator
B1K54_RS18900	COG1522	sequence-specific DNA binding
B1K54_RS18925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B1K54_RS18950	COG4591	ABC-type transport system involved in lipoprotein release permease component
B1K54_RS18950	COG1136	(ABC) transporter
B1K54_RS18965	COG0515	serine threonine protein kinase
B1K54_RS18970	COG0515	serine threonine protein kinase
B1K54_RS18985	COG0022	dehydrogenase e1 component
B1K54_RS18990	COG0508	dehydrogenase complex catalyzes the overall conversion of
B1K54_RS19075	COG1362	aminopeptidase activity
B1K54_RS19085	COG1960	acyl-CoA dehydrogenase activity
B1K54_RS19115	COG0640	Transcriptional regulator
B1K54_RS19135	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B1K54_RS19150	COG2205	protein histidine kinase activity
B1K54_RS19160	COG1289	transmembrane transporter activity
B1K54_RS19230	COG1278	Cold shock
B1K54_RS19285	COG1181	Belongs to the D-alanine--D-alanine ligase family
B1K54_RS19290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B1K54_RS19315	COG0017	Asparaginyl-tRNA synthetase
B1K54_RS19325	COG2124	cytochrome p450
B1K54_RS19330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B1K54_RS19335	COG1619	proteins homologs of microcin C7 resistance protein MccF
B1K54_RS19375	COG1120	ATPase activity
B1K54_RS19380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1K54_RS19405	COG1733	regulation of RNA biosynthetic process
B1K54_RS19410	COG0702	epimerase
B1K54_RS19415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1K54_RS19420	COG0596	Alpha beta hydrolase
B1K54_RS19425	COG3226	Transcriptional regulator
B1K54_RS19455	COG0717	Belongs to the dCTP deaminase family
B1K54_RS19475	COG2181	nitrate reductase activity
B1K54_RS19475	COG0247	lactate metabolic process
B1K54_RS19485	COG0443	Heat shock 70 kDa protein
B1K54_RS19490	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B1K54_RS19495	COG0484	heat shock protein binding
B1K54_RS19500	COG0789	Transcriptional regulator
B1K54_RS19525	COG0542	response to heat
B1K54_RS19590	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B1K54_RS19605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B1K54_RS19610	COG0191	fructose-bisphosphate aldolase activity
B1K54_RS19660	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B1K54_RS19675	COG2197	response regulator
B1K54_RS19680	COG4585	Histidine kinase
B1K54_RS19685	COG2197	response regulator
B1K54_RS19690	COG4585	Histidine kinase
B1K54_RS19725	COG0693	protein deglycase activity
B1K54_RS19730	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B1K54_RS19750	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B1K54_RS19755	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B1K54_RS19775	COG1595	DNA-templated transcription, initiation
B1K54_RS19795	COG0402	S-adenosylhomocysteine deaminase activity
B1K54_RS19920	COG1408	metallophosphoesterase
B1K54_RS19930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B1K54_RS19945	COG0003	Pfam Anion-transporting ATPase
B1K54_RS19965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1K54_RS20000	COG2267	carboxylic ester hydrolase activity
B1K54_RS20010	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B1K54_RS20015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1K54_RS20075	COG1205	dead DEAH box helicase
B1K54_RS20075	COG1111	helicase
B1K54_RS20080	COG1366	Belongs to the anti-sigma-factor antagonist family
B1K54_RS20090	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
B1K54_RS20100	COG2890	protein-(glutamine-N5) methyltransferase activity
B1K54_RS20105	COG1754	DNA topoisomerase type I activity
B1K54_RS20105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B1K54_RS20110	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B1K54_RS20185	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B1K54_RS20195	COG3486	L-lysine 6-monooxygenase (NADPH) activity
B1K54_RS20200	COG3903	Transcriptional regulator
B1K54_RS20200	COG3629	intracellular signal transduction
B1K54_RS20245	COG1674	ftsk spoiiie
B1K54_RS20285	COG1595	DNA-templated transcription, initiation
B1K54_RS20295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B1K54_RS20295	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B1K54_RS20320	COG1012	belongs to the aldehyde dehydrogenase family
B1K54_RS20325	COG0768	penicillin binding
B1K54_RS20330	COG2318	DinB family
B1K54_RS20335	COG0789	Transcriptional regulator
B1K54_RS20340	COG0586	Pfam SNARE associated Golgi protein
B1K54_RS20350	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B1K54_RS20355	COG2027	D-alanyl-D-alanine carboxypeptidase
B1K54_RS20365	COG0037	tRNA processing
B1K54_RS20370	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B1K54_RS20380	COG0302	gtp cyclohydrolase
B1K54_RS20390	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B1K54_RS20395	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B1K54_RS20410	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B1K54_RS20410	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B1K54_RS20425	COG1174	glycine betaine transport
B1K54_RS20435	COG1732	Glycine betaine
B1K54_RS20445	COG1309	transcriptional regulator
B1K54_RS20450	COG2084	Dehydrogenase
B1K54_RS20465	COG0649	NAD binding
B1K54_RS20480	COG2197	response regulator
B1K54_RS20515	COG2843	Capsule synthesis protein
B1K54_RS20530	COG0640	Transcriptional regulator
B1K54_RS20545	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B1K54_RS20555	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B1K54_RS20560	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B1K54_RS20570	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
B1K54_RS20590	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B1K54_RS20615	COG0739	heme binding
B1K54_RS20625	COG2205	protein histidine kinase activity
B1K54_RS20630	COG0745	RESPONSE REGULATOR receiver
B1K54_RS20640	COG1595	DNA-templated transcription, initiation
B1K54_RS20645	COG1194	a g-specific adenine glycosylase
B1K54_RS20650	COG0671	phosphoesterase, PA-phosphatase related
B1K54_RS20660	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
B1K54_RS20680	COG0248	Ppx GppA phosphatase
B1K54_RS20690	COG1082	Xylose isomerase domain protein TIM barrel
B1K54_RS20700	COG0129	dihydroxy-acid dehydratase activity
B1K54_RS20710	COG4991	sh3 domain protein
B1K54_RS20720	COG0842	Transport permease protein
B1K54_RS20720	COG1129	ABC transporter
B1K54_RS20730	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B1K54_RS20735	COG0180	Tryptophanyl-tRNA synthetase
B1K54_RS20770	COG0123	including yeast histone deacetylase and acetoin utilization protein
B1K54_RS20820	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
B1K54_RS20825	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B1K54_RS20830	COG0181	hydroxymethylbilane synthase activity
B1K54_RS20835	COG1648	precorrin-2 dehydrogenase activity
B1K54_RS20835	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B1K54_RS20860	COG0113	porphobilinogen synthase activity
B1K54_RS20985	COG0018	arginyl-trna synthetase
B1K54_RS20990	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
B1K54_RS21010	COG1690	Belongs to the RtcB family
B1K54_RS21030	COG1742	UPF0060 membrane protein
B1K54_RS21045	COG1733	regulation of RNA biosynthetic process
B1K54_RS21050	COG3321	synthase
B1K54_RS21050	COG4221	oxidoreductase activity
B1K54_RS21050	COG0604	alcohol dehydrogenase
B1K54_RS21050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B1K54_RS21065	COG1136	(ABC) transporter
B1K54_RS21065	COG0577	efflux transmembrane transporter activity
B1K54_RS21070	COG0577	efflux transmembrane transporter activity
B1K54_RS21070	COG1136	(ABC) transporter
B1K54_RS21140	COG0464	growth
B1K54_RS21150	COG4946	Tricorn protease homolog
B1K54_RS21150	COG0793	Belongs to the peptidase S41A family
B1K54_RS21155	COG2197	response regulator
B1K54_RS21170	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B1K54_RS21175	COG0406	alpha-ribazole phosphatase activity
B1K54_RS21190	COG0785	Cytochrome C biogenesis protein
B1K54_RS21195	COG1333	cytochrome c biogenesis protein
B1K54_RS21200	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B1K54_RS21225	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B1K54_RS21235	COG0109	protoheme IX farnesyltransferase activity
B1K54_RS21245	COG0705	Rhomboid family
B1K54_RS21250	COG0163	prenyltransferase activity
B1K54_RS21260	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B1K54_RS21275	COG1301	dicarboxylic acid transport
B1K54_RS21350	COG1278	Cold shock
B1K54_RS21355	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
B1K54_RS21365	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B1K54_RS21385	COG2226	methyltransferase
B1K54_RS21390	COG2066	Belongs to the glutaminase family
B1K54_RS21420	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1K54_RS21425	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1K54_RS21430	COG0649	NAD binding
B1K54_RS21440	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B1K54_RS21445	COG1034	ATP synthesis coupled electron transport
B1K54_RS21450	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B1K54_RS21455	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1K54_RS21460	COG0839	Belongs to the complex I subunit 6 family
B1K54_RS21465	COG0713	ATP synthesis coupled electron transport
B1K54_RS21470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B1K54_RS21480	COG1007	ATP synthesis coupled electron transport
B1K54_RS21505	COG2936	dipeptidyl-peptidase activity
B1K54_RS21510	COG0142	geranyltranstransferase activity
B1K54_RS21540	COG0702	epimerase
B1K54_RS21545	COG1013	pyruvate-flavodoxin oxidoreductase activity
B1K54_RS21550	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B1K54_RS21550	COG0674	pyruvate-flavodoxin oxidoreductase activity
B1K54_RS21570	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1K54_RS21575	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1K54_RS21580	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1K54_RS21585	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B1K54_RS21590	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1K54_RS21595	COG0839	Belongs to the complex I subunit 6 family
B1K54_RS21600	COG0713	ATP synthesis coupled electron transport
B1K54_RS21605	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B1K54_RS21615	COG1007	ATP synthesis coupled electron transport
B1K54_RS21620	COG0501	Belongs to the peptidase M48B family
B1K54_RS21625	COG3304	Inner membrane component domain
B1K54_RS21640	COG0659	secondary active sulfate transmembrane transporter activity
B1K54_RS21645	COG1666	GTP binding
B1K54_RS21680	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B1K54_RS21685	COG2030	dehydratase
B1K54_RS21710	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B1K54_RS21720	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B1K54_RS21725	COG0436	Aminotransferase
B1K54_RS21735	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B1K54_RS21745	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B1K54_RS21750	COG0081	regulation of translation
B1K54_RS21765	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B1K54_RS21770	COG0222	ribosome binding
B1K54_RS21780	COG0085	RNA polymerase activity
B1K54_RS21785	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B1K54_RS21795	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B1K54_RS21800	COG0049	tRNA binding
B1K54_RS21805	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B1K54_RS21810	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B1K54_RS21840	COG1215	transferase activity, transferring glycosyl groups
B1K54_RS21870	COG0051	transcription antitermination factor activity, RNA binding
B1K54_RS21875	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B1K54_RS21880	COG0088	Forms part of the polypeptide exit tunnel
B1K54_RS21885	COG0089	rRNA binding
B1K54_RS21890	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B1K54_RS21895	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B1K54_RS21900	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B1K54_RS21905	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B1K54_RS21910	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B1K54_RS21915	COG0255	Belongs to the universal ribosomal protein uL29 family
B1K54_RS21920	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B1K54_RS21925	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B1K54_RS21930	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B1K54_RS21935	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B1K54_RS21940	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B1K54_RS21950	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B1K54_RS21955	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B1K54_RS21960	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B1K54_RS21965	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B1K54_RS21970	COG1841	ribosomal large subunit assembly
B1K54_RS21975	COG0200	Binds to the 23S rRNA
B1K54_RS21980	COG0201	protein transport
B1K54_RS21985	COG0563	adenylate kinase activity
B1K54_RS21995	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B1K54_RS22000	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B1K54_RS22005	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B1K54_RS22010	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B1K54_RS22015	COG0202	RNA polymerase activity
B1K54_RS22020	COG0203	ribosomal protein L17
B1K54_RS22025	COG0101	tRNA pseudouridine synthase activity
B1K54_RS22030	COG0488	(ABC) transporter
B1K54_RS22040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B1K54_RS22045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B1K54_RS22050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1K54_RS22055	COG1072	(Pantothenic acid kinase))
B1K54_RS22065	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B1K54_RS22070	COG0736	holo-[acyl-carrier-protein] synthase activity
B1K54_RS22080	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B1K54_RS22090	COG0802	atpase or kinase
B1K54_RS22115	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B1K54_RS22130	COG0726	polysaccharide deacetylase
B1K54_RS22135	COG0726	polysaccharide deacetylase
B1K54_RS22155	COG2188	Transcriptional regulator
B1K54_RS22180	COG0772	Belongs to the SEDS family
B1K54_RS22185	COG1316	TRANSCRIPTIONal
B1K54_RS22190	COG2205	protein histidine kinase activity
B1K54_RS22195	COG0745	RESPONSE REGULATOR receiver
B1K54_RS22205	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B1K54_RS22210	COG0459	protein refolding
B1K54_RS22220	COG4221	oxidoreductase activity
B1K54_RS22230	COG0583	DNA-binding transcription factor activity
B1K54_RS22245	COG1595	DNA-templated transcription, initiation
B1K54_RS22255	COG0516	GMP reductase activity
B1K54_RS22265	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B1K54_RS22270	COG0515	serine threonine protein kinase
B1K54_RS22280	COG0515	serine threonine protein kinase
B1K54_RS22285	COG1012	belongs to the aldehyde dehydrogenase family
B1K54_RS22305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B1K54_RS22305	COG0519	Catalyzes the synthesis of GMP from XMP
B1K54_RS22340	COG2197	response regulator
B1K54_RS22360	COG0640	Transcriptional regulator
B1K54_RS22380	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1K54_RS22380	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1K54_RS22395	COG0714	Associated with various cellular activities
B1K54_RS22400	COG2425	protein containing a von Willebrand factor type A (vWA) domain
B1K54_RS22405	COG3552	Protein containing von Willebrand factor type A (VWA) domain
B1K54_RS22410	COG0045	succinate-CoA ligase (ADP-forming) activity
B1K54_RS22445	COG0138	bifunctional purine biosynthesis protein purh
B1K54_RS22455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B1K54_RS22465	COG0039	L-malate dehydrogenase activity
B1K54_RS22470	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B1K54_RS22475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B1K54_RS22490	COG0754	glutathionylspermidine amidase activity
B1K54_RS22495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B1K54_RS22500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B1K54_RS22505	COG0180	Tryptophanyl-tRNA synthetase
B1K54_RS22515	COG1295	ribonuclease BN
B1K54_RS22520	COG1686	Belongs to the peptidase S11 family
B1K54_RS22530	COG1408	metallophosphoesterase
B1K54_RS22540	COG1309	transcriptional regulator
B1K54_RS22560	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B1K54_RS22565	COG1053	succinate dehydrogenase
B1K54_RS22575	COG2009	succinate dehydrogenase
B1K54_RS22585	COG1595	DNA-templated transcription, initiation
B1K54_RS22600	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1K54_RS22600	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1K54_RS22615	COG1216	Glycosyl transferase, family 2
B1K54_RS22625	COG2089	acid synthase
B1K54_RS22635	COG1473	amidohydrolase
B1K54_RS22635	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B1K54_RS22640	COG1744	ABC transporter substrate-binding protein PnrA-like
B1K54_RS22645	COG3845	ABC transporter
B1K54_RS22655	COG1079	Belongs to the binding-protein-dependent transport system permease family
B1K54_RS22695	COG2814	Major facilitator Superfamily
B1K54_RS22700	COG0583	DNA-binding transcription factor activity
B1K54_RS22725	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B1K54_RS22765	COG1012	belongs to the aldehyde dehydrogenase family
B1K54_RS22770	COG1012	belongs to the aldehyde dehydrogenase family
B1K54_RS22785	COG1595	DNA-templated transcription, initiation
B1K54_RS22790	COG0745	RESPONSE REGULATOR receiver
B1K54_RS22795	COG2205	protein histidine kinase activity
B1K54_RS22805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1K54_RS22835	COG4770	biotin carboxylase activity
B1K54_RS22845	COG0424	maF-like protein
B1K54_RS22855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B1K54_RS22870	COG1024	Enoyl-CoA hydratase
B1K54_RS22880	COG2986	histidine ammonia-lyase
B1K54_RS22895	COG1376	ErfK ybiS ycfS ynhG family protein
B1K54_RS22910	COG1064	alcohol dehydrogenase
B1K54_RS22915	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1K54_RS22925	COG0501	Belongs to the peptidase M48B family
B1K54_RS22945	COG1595	DNA-templated transcription, initiation
B1K54_RS22955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B1K54_RS22960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B1K54_RS22970	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B1K54_RS23000	COG1331	Highly conserved protein containing a thioredoxin domain
B1K54_RS23015	COG0463	Glycosyl transferase, family 2
B1K54_RS23030	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
B1K54_RS23135	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
B1K54_RS23145	COG1414	Transcriptional regulator
B1K54_RS23175	COG2894	cell division
B1K54_RS23225	COG2885	chlorophyll binding
B1K54_RS23260	COG0596	Alpha beta hydrolase
B1K54_RS23275	COG0477	Major facilitator Superfamily
B1K54_RS23280	COG0726	polysaccharide deacetylase
B1K54_RS23320	COG0667	Aldo Keto reductase
B1K54_RS23325	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B1K54_RS23330	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B1K54_RS23355	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B1K54_RS23360	COG0450	alkyl hydroperoxide reductase
B1K54_RS23375	COG1136	(ABC) transporter
B1K54_RS23395	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B1K54_RS23410	COG0114	fumarate hydratase activity
B1K54_RS23430	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
B1K54_RS23430	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
B1K54_RS23460	COG0778	Nitroreductase
B1K54_RS23465	COG1722	exodeoxyribonuclease VII activity
B1K54_RS23470	COG1570	exodeoxyribonuclease VII activity
B1K54_RS23480	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B1K54_RS23495	COG0012	GTP binding
B1K54_RS23520	COG1695	Transcriptional regulator
B1K54_RS23565	COG0697	spore germination
B1K54_RS23615	COG1842	Phage shock protein A
B1K54_RS23630	COG1053	succinate dehydrogenase
B1K54_RS23650	COG1217	gtp-binding protein TYPA
B1K54_RS23655	COG4166	transmembrane transport
B1K54_RS23660	COG0601	transmembrane transport
B1K54_RS23665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1K54_RS23675	COG4608	Belongs to the ABC transporter superfamily
B1K54_RS23685	COG4166	transmembrane transport
B1K54_RS23690	COG0601	transmembrane transport
B1K54_RS23695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1K54_RS23705	COG4608	Belongs to the ABC transporter superfamily
B1K54_RS23715	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B1K54_RS23770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B1K54_RS23775	COG1611	Belongs to the LOG family
B1K54_RS23780	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B1K54_RS23790	COG0519	Catalyzes the synthesis of GMP from XMP
B1K54_RS23795	COG1024	Enoyl-CoA hydratase
B1K54_RS23815	COG1595	DNA-templated transcription, initiation
B1K54_RS23825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1K54_RS23830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1K54_RS23865	COG0598	Magnesium transport protein CorA
B1K54_RS23885	COG2095	MarC family integral membrane protein
B1K54_RS23890	COG2267	carboxylic ester hydrolase activity
B1K54_RS24005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B1K54_RS24045	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B1K54_RS24100	COG3480	Lon protease (S16) C-terminal proteolytic domain
B1K54_RS24110	COG1615	UPF0182 protein
B1K54_RS24135	COG0753	catalase activity
B1K54_RS24145	COG0483	inositol monophosphate 1-phosphatase activity
B1K54_RS24155	COG2076	Multidrug Resistance protein
B1K54_RS24165	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B1K54_RS24175	COG2135	peptidase activity
B1K54_RS24185	COG1595	DNA-templated transcription, initiation
B1K54_RS24190	COG5662	AntiSigma factor
B1K54_RS24195	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B1K54_RS24195	COG2199	diguanylate cyclase activity
B1K54_RS24210	COG0242	peptide deformylase activity
B1K54_RS24255	COG1966	Carbon starvation protein
B1K54_RS24260	COG2188	Transcriptional regulator
B1K54_RS24265	COG2182	Extracellular solute-binding protein
B1K54_RS24270	COG1175	transmembrane transport
B1K54_RS24275	COG0395	ABC-type sugar transport system, permease component
B1K54_RS24280	COG1472	Belongs to the glycosyl hydrolase 3 family
B1K54_RS24285	COG0363	glucosamine-6-phosphate deaminase activity
B1K54_RS24295	COG1028	Short-chain dehydrogenase reductase Sdr
B1K54_RS24300	COG1309	transcriptional regulator
B1K54_RS24370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B1K54_RS24370	COG1017	nitric oxide dioxygenase activity
B1K54_RS24375	COG1959	2 iron, 2 sulfur cluster binding
B1K54_RS24380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1K54_RS24385	COG0142	geranyltranstransferase activity
B1K54_RS24400	COG5640	endopeptidase activity
B1K54_RS24435	COG0604	alcohol dehydrogenase
B1K54_RS24455	COG0765	amino acid transport
B1K54_RS24460	COG1126	abc transporter atp-binding protein
B1K54_RS24465	COG4106	trans-aconitate 2-methyltransferase activity
B1K54_RS24535	COG0508	dehydrogenase complex catalyzes the overall conversion of
B1K54_RS24535	COG0567	Dehydrogenase, E1 component
B1K54_RS24540	COG2205	protein histidine kinase activity
B1K54_RS24545	COG0745	RESPONSE REGULATOR receiver
B1K54_RS24565	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B1K54_RS24580	COG5002	protein histidine kinase activity
B1K54_RS24630	COG0739	heme binding
B1K54_RS24645	COG1309	transcriptional regulator
B1K54_RS24655	COG2205	protein histidine kinase activity
B1K54_RS24675	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B1K54_RS24680	COG1793	dna ligase
B1K54_RS24680	COG3285	dna ligase
B1K54_RS24685	COG1793	dna ligase
B1K54_RS24695	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B1K54_RS24695	COG3608	succinylglutamate desuccinylase aspartoacylase
B1K54_RS24725	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
B1K54_RS24735	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
B1K54_RS24750	COG0018	arginyl-trna synthetase
B1K54_RS24755	COG0019	diaminopimelate decarboxylase activity
B1K54_RS24765	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B1K54_RS24770	COG0083	homoserine kinase activity
B1K54_RS24780	COG0254	rRNA binding
B1K54_RS24785	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B1K54_RS24790	COG2890	protein-(glutamine-N5) methyltransferase activity
B1K54_RS24800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B1K54_RS24805	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B1K54_RS24825	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B1K54_RS24830	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B1K54_RS24835	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B1K54_RS24840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B1K54_RS24845	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B1K54_RS24850	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B1K54_RS24855	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B1K54_RS24870	COG2197	response regulator
B1K54_RS24890	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1K54_RS24905	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
B1K54_RS24960	COG0183	Belongs to the thiolase family
B1K54_RS24965	COG1703	isobutyryl-CoA mutase activity
B1K54_RS25040	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1K54_RS25040	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1K54_RS25075	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B1K54_RS25080	COG0280	phosphate acetyltransferase
B1K54_RS25080	COG0857	belongs to the CobB CobQ family
B1K54_RS25085	COG0205	6-phosphofructokinase activity
B1K54_RS25115	COG0366	Alpha amylase catalytic
B1K54_RS25120	COG0058	SHG alpha-glucan phosphorylase activity
B1K54_RS25130	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B1K54_RS25135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1K54_RS25140	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
B1K54_RS25165	COG0110	maltose O-acetyltransferase activity
B1K54_RS25180	COG0489	protein tyrosine kinase activity
B1K54_RS25185	COG0297	glycogen (starch) synthase activity
B1K54_RS25275	COG1760	l-serine dehydratase
B1K54_RS25280	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B1K54_RS25285	COG0509	glycine decarboxylation via glycine cleavage system
B1K54_RS25290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B1K54_RS25315	COG0747	negative chemotaxis
B1K54_RS25325	COG0444	Belongs to the ABC transporter superfamily
B1K54_RS25330	COG4608	Belongs to the ABC transporter superfamily
B1K54_RS25335	COG2860	membrane
B1K54_RS25350	COG3023	N-Acetylmuramoyl-L-alanine amidase
B1K54_RS25355	COG0482	sulfurtransferase activity
B1K54_RS25365	COG4977	sequence-specific DNA binding
B1K54_RS25390	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B1K54_RS25400	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B1K54_RS25405	COG0154	amidase activity
B1K54_RS25415	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B1K54_RS25445	COG2375	cellular response to nickel ion
B1K54_RS25445	COG1132	(ABC) transporter
B1K54_RS25450	COG2318	DinB family
B1K54_RS25465	COG2409	Drug exporters of the RND superfamily
B1K54_RS25470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B1K54_RS25480	COG2133	pyrroloquinoline quinone binding
B1K54_RS25485	COG0667	Aldo Keto reductase
B1K54_RS25505	COG0440	acetolactate synthase activity
B1K54_RS25510	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B1K54_RS25530	COG0506	proline dehydrogenase activity
B1K54_RS25535	COG1012	belongs to the aldehyde dehydrogenase family
B1K54_RS25540	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
B1K54_RS25540	COG0778	Nitroreductase
B1K54_RS25555	COG3511	phospholipase C
B1K54_RS25565	COG0583	DNA-binding transcription factor activity
B1K54_RS25570	COG0473	3-isopropylmalate dehydrogenase activity
B1K54_RS25575	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B1K54_RS25585	COG0831	urea catabolic process
B1K54_RS25585	COG0832	Belongs to the urease beta subunit family
B1K54_RS25590	COG0804	urea catabolic process
B1K54_RS25595	COG2957	Belongs to the agmatine deiminase family
B1K54_RS25605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1K54_RS25615	COG2353	YceI-like domain
B1K54_RS25620	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B1K54_RS25640	COG2018	Roadblock/LC7 domain
B1K54_RS25660	COG2018	Roadblock/LC7 domain
B1K54_RS25665	COG5002	protein histidine kinase activity
B1K54_RS25675	COG0179	Fumarylacetoacetate (FAA) hydrolase
B1K54_RS25680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B1K54_RS25685	COG1011	Hydrolase
B1K54_RS25720	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B1K54_RS25725	COG0066	3-isopropylmalate dehydratase activity
B1K54_RS25735	COG0776	regulation of translation
B1K54_RS25740	COG1920	GTP binding
B1K54_RS25750	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B1K54_RS25755	COG1181	Belongs to the D-alanine--D-alanine ligase family
B1K54_RS25775	COG0351	phosphomethylpyrimidine kinase
B1K54_RS25780	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B1K54_RS25785	COG1461	Dihydroxyacetone kinase
B1K54_RS25790	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B1K54_RS25795	COG0742	ribosomal rna small subunit methyltransferase
B1K54_RS25800	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B1K54_RS25815	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B1K54_RS25820	COG0571	ribonuclease III activity
B1K54_RS25825	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B1K54_RS25830	COG1733	regulation of RNA biosynthetic process
B1K54_RS25840	COG2340	Cysteine-rich secretory protein family
B1K54_RS25845	COG1254	Belongs to the acylphosphatase family
B1K54_RS25855	COG1196	nuclear chromosome segregation
B1K54_RS25860	COG0477	Major facilitator Superfamily
B1K54_RS25900	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B1K54_RS25915	COG0442	prolyl-tRNA aminoacylation
B1K54_RS25925	COG0228	four-way junction DNA binding
B1K54_RS25930	COG1837	Belongs to the UPF0109 family
B1K54_RS25935	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B1K54_RS25940	COG0336	Belongs to the RNA methyltransferase TrmD family
B1K54_RS25945	COG0335	large ribosomal subunit rRNA binding
B1K54_RS25965	COG0681	Belongs to the peptidase S26 family
B1K54_RS25980	COG0792	nuclease activity
B1K54_RS25995	COG1191	sigma factor activity
B1K54_RS26010	COG0052	Belongs to the universal ribosomal protein uS2 family
B1K54_RS26015	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B1K54_RS26020	COG0528	UMP kinase activity
B1K54_RS26025	COG0233	cytoplasmic translational termination
B1K54_RS26035	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B1K54_RS26050	COG3842	ATPase activity
B1K54_RS26060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B1K54_RS26095	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B1K54_RS26105	COG1012	belongs to the aldehyde dehydrogenase family
B1K54_RS26115	COG0584	glycerophosphoryl diester phosphodiesterase
B1K54_RS26120	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B1K54_RS26145	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B1K54_RS26150	COG3842	ATPase activity
B1K54_RS26155	COG1176	ABC-type spermidine putrescine transport system, permease component I
B1K54_RS26160	COG1177	transmembrane transport
B1K54_RS26165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1K54_RS26195	COG2508	Transcriptional regulator
B1K54_RS26200	COG1012	belongs to the aldehyde dehydrogenase family
B1K54_RS26215	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B1K54_RS26220	COG0750	zinc metalloprotease
B1K54_RS26225	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B1K54_RS26240	COG0442	prolyl-tRNA aminoacylation
B1K54_RS26245	COG0330	HflC and HflK could
B1K54_RS26265	COG0779	Required for maturation of 30S ribosomal subunits
B1K54_RS26290	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B1K54_RS26295	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B1K54_RS26310	COG0455	bacterial-type flagellum organization
B1K54_RS26330	COG1404	Belongs to the peptidase S8 family
B1K54_RS26350	COG1674	ftsk spoiiie
B1K54_RS26360	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B1K54_RS26365	COG1185	polyribonucleotide nucleotidyltransferase activity
B1K54_RS26370	COG0612	Peptidase, M16
B1K54_RS26375	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B1K54_RS26395	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
B1K54_RS26400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B1K54_RS26405	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B1K54_RS26435	COG2318	DinB family
B1K54_RS26440	COG2208	phosphoserine phosphatase activity
B1K54_RS26440	COG2770	Histidine kinase
B1K54_RS26450	COG3437	response regulator, receiver
B1K54_RS26450	COG4999	Histidine kinase
B1K54_RS26450	COG2205	protein histidine kinase activity
B1K54_RS26450	COG3850	Histidine kinase
B1K54_RS26460	COG1674	ftsk spoiiie
B1K54_RS26470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B1K54_RS26480	COG1546	Belongs to the CinA family
B1K54_RS26480	COG1058	Belongs to the CinA family
B1K54_RS26485	COG1396	sequence-specific DNA binding
B1K54_RS26495	COG1028	Short-chain dehydrogenase reductase Sdr
B1K54_RS26500	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B1K54_RS26510	COG1201	RNA secondary structure unwinding
B1K54_RS26515	COG2207	Transcriptional regulator
B1K54_RS26515	COG1917	Cupin 2, conserved barrel domain protein
B1K54_RS26550	COG2226	methyltransferase
B1K54_RS26555	COG1619	proteins homologs of microcin C7 resistance protein MccF
B1K54_RS26565	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B1K54_RS26590	COG0765	amino acid transport
B1K54_RS26595	COG0765	amino acid transport
B1K54_RS26600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1K54_RS26605	COG1126	abc transporter atp-binding protein
B1K54_RS26615	COG2205	protein histidine kinase activity
B1K54_RS26635	COG1940	carbohydrate kinase activity
B1K54_RS26650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B1K54_RS26670	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B1K54_RS26680	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B1K54_RS26685	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B1K54_RS26695	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B1K54_RS26730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B1K54_RS26735	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B1K54_RS26740	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B1K54_RS26750	COG0406	alpha-ribazole phosphatase activity
B1K54_RS26765	COG0110	maltose O-acetyltransferase activity
B1K54_RS26780	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B1K54_RS26830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B1K54_RS26855	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B1K54_RS26860	COG4565	transcriptional regulatory protein
B1K54_RS26865	COG3290	protein histidine kinase activity
B1K54_RS26875	COG0372	Belongs to the citrate synthase family
B1K54_RS26900	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B1K54_RS26905	COG0612	Peptidase, M16
B1K54_RS26920	COG1802	Transcriptional regulator
B1K54_RS26925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B1K54_RS26945	COG1435	thymidine kinase activity
B1K54_RS26960	COG0671	phosphoesterase, PA-phosphatase related
B1K54_RS26965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B1K54_RS26990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B1K54_RS27000	COG0438	transferase activity, transferring glycosyl groups
B1K54_RS27045	COG1271	oxidase subunit
B1K54_RS27050	COG1028	Short-chain dehydrogenase reductase Sdr
B1K54_RS27125	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B1K54_RS27140	COG0745	RESPONSE REGULATOR receiver
B1K54_RS27145	COG2205	protein histidine kinase activity
B1K54_RS27170	COG0756	dUTP diphosphatase activity
B1K54_RS27205	COG0569	domain protein
B1K54_RS27210	COG0531	amino acid
B1K54_RS27215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B1K54_RS27235	COG0477	Major facilitator Superfamily
B1K54_RS27260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B1K54_RS27265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1K54_RS27285	COG0515	serine threonine protein kinase
B1K54_RS27315	COG2267	carboxylic ester hydrolase activity
B1K54_RS27320	COG3629	intracellular signal transduction
B1K54_RS27320	COG3903	Transcriptional regulator
B1K54_RS27355	COG1609	Transcriptional regulator
B1K54_RS27395	COG2259	Doxx family
B1K54_RS27425	COG2311	Membrane
B1K54_RS27430	COG0454	-acetyltransferase
B1K54_RS27430	COG0456	acetyltransferase
B1K54_RS27460	COG4326	sporulation control protein
B1K54_RS27510	COG0438	transferase activity, transferring glycosyl groups
B1K54_RS27515	COG2197	response regulator
B1K54_RS27525	COG1136	(ABC) transporter
B1K54_RS27535	COG2197	response regulator
B1K54_RS27555	COG3251	PFAM MbtH domain protein
B1K54_RS27565	COG2175	clavaminate synthase activity
B1K54_RS27580	COG0640	Transcriptional regulator
B1K54_RS27605	COG1834	amidinotransferase
B1K54_RS27645	COG2124	cytochrome p450
B1K54_RS27650	COG2124	cytochrome p450
B1K54_RS27655	COG0644	oxidoreductase
B1K54_RS27680	COG0604	alcohol dehydrogenase
B1K54_RS27680	COG3321	synthase
B1K54_RS27695	COG0436	Aminotransferase
B1K54_RS27720	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B1K54_RS27725	COG2409	Drug exporters of the RND superfamily
B1K54_RS27735	COG0252	asparaginase activity
B1K54_RS27770	COG0431	NADPH-dependent FMN reductase
B1K54_RS27790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1K54_RS27805	COG1799	cell septum assembly
B1K54_RS27835	COG2040	homocysteine
B1K54_RS27855	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B1K54_RS27870	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B1K54_RS27880	COG1024	Enoyl-CoA hydratase
B1K54_RS27895	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B1K54_RS27900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B1K54_RS27915	COG0515	serine threonine protein kinase
B1K54_RS27920	COG0318	PFAM AMP-dependent synthetase and ligase
B1K54_RS27925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B1K54_RS27935	COG0318	PFAM AMP-dependent synthetase and ligase
B1K54_RS27940	COG3321	synthase
B1K54_RS27940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B1K54_RS27950	COG1028	Short-chain dehydrogenase reductase Sdr
B1K54_RS27970	COG2030	dehydratase
B1K54_RS28025	COG0006	proline dipeptidase activity
B1K54_RS28035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1K54_RS28055	COG3938	Belongs to the proline racemase family
B1K54_RS28085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1K54_RS28100	COG4608	Belongs to the ABC transporter superfamily
B1K54_RS28150	COG3708	Transcriptional regulator
B1K54_RS28150	COG2207	Transcriptional regulator
B1K54_RS28160	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B1K54_RS28200	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B1K54_RS28205	COG1653	transport
B1K54_RS28210	COG1175	transmembrane transport
B1K54_RS28215	COG0395	ABC-type sugar transport system, permease component
B1K54_RS28230	COG1940	carbohydrate kinase activity
B1K54_RS28235	COG4213	ABC transporter substrate-binding protein
B1K54_RS28245	COG4214	carbohydrate transport
B1K54_RS28250	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B1K54_RS28255	COG0531	amino acid
B1K54_RS28260	COG1316	TRANSCRIPTIONal
B1K54_RS28265	COG1024	Enoyl-CoA hydratase
B1K54_RS28265	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1K54_RS28270	COG0183	Belongs to the thiolase family
B1K54_RS28280	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
B1K54_RS28295	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B1K54_RS28300	COG0446	pyridine nucleotide-disulphide oxidoreductase
B1K54_RS28310	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B1K54_RS28315	COG3253	May function as heme-dependent peroxidase
B1K54_RS28320	COG0596	Alpha beta hydrolase
B1K54_RS28330	COG3220	belongs to the UPF0276 family
B1K54_RS28380	COG2124	cytochrome p450
B1K54_RS28410	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B1K54_RS28415	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1K54_RS28455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1K54_RS28465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B1K54_RS28470	COG3511	phospholipase C
B1K54_RS28490	COG0504	CTP synthase activity
B1K54_RS28525	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B1K54_RS28530	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B1K54_RS28590	COG2409	Drug exporters of the RND superfamily
B1K54_RS28595	COG4585	Histidine kinase
B1K54_RS28600	COG2197	response regulator
B1K54_RS28635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B1K54_RS28640	COG1116	anion transmembrane transporter activity
B1K54_RS28660	COG0529	Catalyzes the synthesis of activated sulfate
B1K54_RS28665	COG0175	sulfate reduction
B1K54_RS28680	COG0456	acetyltransferase
B1K54_RS28690	COG1960	acyl-CoA dehydrogenase activity
B1K54_RS28710	COG1162	GTPase activity
B1K54_RS28740	COG0028	Belongs to the TPP enzyme family
B1K54_RS28760	COG1802	Transcriptional regulator
B1K54_RS28785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B1K54_RS28790	COG2252	PERMEase
B1K54_RS28805	COG4552	Acetyltransferase involved in intracellular survival and related
B1K54_RS28910	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B1K54_RS28915	COG0318	PFAM AMP-dependent synthetase and ligase
B1K54_RS28920	COG1960	acyl-CoA dehydrogenase activity
B1K54_RS28925	COG0318	PFAM AMP-dependent synthetase and ligase
B1K54_RS28925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B1K54_RS28925	COG1028	Short-chain dehydrogenase reductase Sdr
B1K54_RS28925	COG3321	synthase
B1K54_RS28925	COG0300	oxidoreductase activity
B1K54_RS28935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B1K54_RS28965	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B1K54_RS28970	COG2197	response regulator
B1K54_RS28970	COG3903	Transcriptional regulator
B1K54_RS28980	COG0318	PFAM AMP-dependent synthetase and ligase
B1K54_RS28985	COG2197	response regulator
B1K54_RS28985	COG3903	Transcriptional regulator
B1K54_RS29000	COG2211	Major facilitator Superfamily
B1K54_RS29020	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B1K54_RS29050	COG0463	Glycosyl transferase, family 2
B1K54_RS29055	COG1595	DNA-templated transcription, initiation
B1K54_RS29075	COG0463	Glycosyl transferase, family 2
B1K54_RS29100	COG1088	dTDP-glucose 4,6-dehydratase activity
B1K54_RS29130	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B1K54_RS29130	COG1024	Enoyl-CoA hydratase
B1K54_RS29170	COG0375	protein maturation
B1K54_RS29225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1K54_RS29230	COG0386	Belongs to the glutathione peroxidase family
B1K54_RS29240	COG3960	tartronate-semialdehyde synthase activity
B1K54_RS29250	COG0753	catalase activity
B1K54_RS29255	COG2084	Dehydrogenase
B1K54_RS29260	COG3622	Belongs to the hyi family
B1K54_RS29280	COG2351	hydroxyisourate hydrolase activity
B1K54_RS29295	COG2233	PERMEase
B1K54_RS29320	COG0515	serine threonine protein kinase
B1K54_RS29325	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B1K54_RS29335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B1K54_RS29340	COG2208	phosphoserine phosphatase activity
B1K54_RS29345	COG2197	response regulator
B1K54_RS29350	COG4585	Histidine kinase
B1K54_RS29360	COG1136	(ABC) transporter
B1K54_RS29365	COG1414	Transcriptional regulator
B1K54_RS29370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B1K54_RS29375	COG4266	Belongs to the allantoicase family
B1K54_RS29385	COG1028	Short-chain dehydrogenase reductase Sdr
B1K54_RS29430	COG0673	inositol 2-dehydrogenase activity
B1K54_RS29440	COG1172	Belongs to the binding-protein-dependent transport system permease family
B1K54_RS29445	COG1129	ABC transporter
B1K54_RS29450	COG1940	carbohydrate kinase activity
B1K54_RS29475	COG1126	abc transporter atp-binding protein
B1K54_RS29500	COG0745	RESPONSE REGULATOR receiver
B1K54_RS29505	COG2205	protein histidine kinase activity
B1K54_RS29525	COG0405	Gamma-glutamyltransferase
B1K54_RS29570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B1K54_RS29575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B1K54_RS29585	COG0483	inositol monophosphate 1-phosphatase activity
B1K54_RS29595	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B1K54_RS29610	COG1448	Aminotransferase
B1K54_RS29615	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B1K54_RS29620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1K54_RS29635	COG1929	Belongs to the glycerate kinase type-1 family
B1K54_RS29640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B1K54_RS29665	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B1K54_RS29680	COG0688	phosphatidylethanolamine metabolic process
B1K54_RS29685	COG1960	acyl-CoA dehydrogenase activity
B1K54_RS29700	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1K54_RS29700	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1K54_RS29705	COG0604	alcohol dehydrogenase
B1K54_RS29715	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1K54_RS29755	COG2362	D-Aminopeptidase
B1K54_RS29760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B1K54_RS29790	COG0457	Tetratricopeptide repeat
B1K54_RS29795	COG2226	methyltransferase
B1K54_RS29835	COG0531	amino acid
B1K54_RS29855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B1K54_RS29865	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B1K54_RS29900	COG2154	pterin-4-alpha-carbinolamine dehydratase
B1K54_RS29915	COG0656	L-ascorbic acid biosynthetic process
B1K54_RS29960	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B1K54_RS29965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B1K54_RS29995	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1K54_RS30030	COG1486	melibiose metabolic process
B1K54_RS30050	COG0494	nUDIX hydrolase
B1K54_RS30070	COG1793	dna ligase
B1K54_RS30120	COG0488	(ABC) transporter
B1K54_RS30140	COG1515	deoxyribonuclease V activity
B1K54_RS30145	COG3268	Saccharopine dehydrogenase
B1K54_RS30160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1K54_RS30165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1K54_RS30170	COG1960	acyl-CoA dehydrogenase activity
B1K54_RS30175	COG0183	Belongs to the thiolase family
B1K54_RS30180	COG1024	Enoyl-CoA hydratase
B1K54_RS30180	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1K54_RS30195	COG0789	Transcriptional regulator
B1K54_RS30285	COG0300	oxidoreductase activity
B1K54_RS30290	COG0488	(ABC) transporter
B1K54_RS30295	COG4977	sequence-specific DNA binding
B1K54_RS30305	COG1024	Enoyl-CoA hydratase
B1K54_RS30320	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B1K54_RS30340	COG0371	Dehydrogenase
B1K54_RS30360	COG1134	teichoic acid transport
B1K54_RS30365	COG1562	ergosterol biosynthetic process
B1K54_RS30380	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B1K54_RS30390	COG1657	PFAM Prenyltransferase squalene oxidase
B1K54_RS30415	COG0739	heme binding
B1K54_RS30420	COG2755	lipolytic protein G-D-S-L family
B1K54_RS30465	COG4172	Belongs to the ABC transporter superfamily
B1K54_RS30470	COG0444	Belongs to the ABC transporter superfamily
B1K54_RS30475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1K54_RS30485	COG0747	negative chemotaxis
B1K54_RS30490	COG1609	Transcriptional regulator
B1K54_RS30550	COG2159	amidohydrolase
B1K54_RS30595	COG2124	cytochrome p450
B1K54_RS30620	COG1172	Belongs to the binding-protein-dependent transport system permease family
B1K54_RS30630	COG2208	phosphoserine phosphatase activity
B1K54_RS30630	COG1366	Belongs to the anti-sigma-factor antagonist family
B1K54_RS30630	COG2172	sigma factor antagonist activity
B1K54_RS30670	COG0583	DNA-binding transcription factor activity
B1K54_RS30680	COG0598	Magnesium transport protein CorA
B1K54_RS30695	COG3152	Membrane
B1K54_RS30700	COG2838	Isocitrate dehydrogenase
B1K54_RS30715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B1K54_RS30725	COG0247	lactate metabolic process
B1K54_RS30730	COG1139	Iron-sulfur cluster binding protein
B1K54_RS30735	COG1556	Lactate utilization protein
B1K54_RS30740	COG0346	lactoylglutathione lyase activity
B1K54_RS30780	COG0297	glycogen (starch) synthase activity
B1K54_RS30790	COG2327	Polysaccharide pyruvyl transferase
B1K54_RS30795	COG0438	transferase activity, transferring glycosyl groups
B1K54_RS30830	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B1K54_RS30840	COG0446	pyridine nucleotide-disulphide oxidoreductase
B1K54_RS30840	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B1K54_RS30875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B1K54_RS30905	COG2124	cytochrome p450
B1K54_RS30910	COG1132	(ABC) transporter
B1K54_RS30920	COG1231	oxidoreductase activity
B1K54_RS30930	COG1335	isochorismatase
B1K54_RS30965	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B1K54_RS31000	COG0142	geranyltranstransferase activity
B1K54_RS31015	COG3345	alpha-galactosidase
B1K54_RS31055	COG1653	transport
B1K54_RS31060	COG1175	transmembrane transport
B1K54_RS31065	COG0395	ABC-type sugar transport system, permease component
B1K54_RS31075	COG1902	pentaerythritol trinitrate reductase activity
B1K54_RS31075	COG0446	pyridine nucleotide-disulphide oxidoreductase
B1K54_RS31105	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B1K54_RS31160	COG0318	PFAM AMP-dependent synthetase and ligase
B1K54_RS31210	COG0577	efflux transmembrane transporter activity
B1K54_RS31210	COG1136	(ABC) transporter
B1K54_RS31255	COG1957	nucleoside hydrolase
B1K54_RS31305	COG0596	Alpha beta hydrolase
B1K54_RS31310	COG2235	arginine
B1K54_RS31315	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B1K54_RS31320	COG0549	Belongs to the carbamate kinase family
B1K54_RS31325	COG1288	antiporter activity
B1K54_RS31340	COG1012	belongs to the aldehyde dehydrogenase family
B1K54_RS31340	COG1454	alcohol dehydrogenase
B1K54_RS31370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B1K54_RS31370	COG0574	Belongs to the PEP-utilizing enzyme family
B1K54_RS31390	COG1840	ABC-type Fe3 transport system, periplasmic component
B1K54_RS31400	COG3842	ATPase activity
B1K54_RS31405	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B1K54_RS31425	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B1K54_RS31475	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B1K54_RS31510	COG0726	polysaccharide deacetylase
B1K54_RS31555	COG0583	DNA-binding transcription factor activity
B1K54_RS31565	COG1053	succinate dehydrogenase
B1K54_RS31570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B1K54_RS31585	COG0598	Magnesium transport protein CorA
B1K54_RS31600	COG1366	Belongs to the anti-sigma-factor antagonist family
B1K54_RS31625	COG3360	Dodecin
B1K54_RS31630	COG2182	Extracellular solute-binding protein
B1K54_RS31645	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
B1K54_RS31650	COG0121	glutamine amidotransferase
B1K54_RS31655	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B1K54_RS31660	COG3572	ergothioneine biosynthetic process
B1K54_RS31745	COG1609	Transcriptional regulator
B1K54_RS31750	COG0183	Belongs to the thiolase family
B1K54_RS31760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B1K54_RS31765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B1K54_RS31785	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B1K54_RS31815	COG2813	Specifically methylates the guanine in position
B1K54_RS31830	COG3693	PFAM glycoside hydrolase, family 10
B1K54_RS31840	COG2160	L-arabinose isomerase activity
B1K54_RS31850	COG1609	Transcriptional regulator
B1K54_RS31855	COG1172	Belongs to the binding-protein-dependent transport system permease family
B1K54_RS31860	COG1172	Belongs to the binding-protein-dependent transport system permease family
B1K54_RS31870	COG1879	ABC-type sugar transport system periplasmic component
B1K54_RS31910	COG1309	transcriptional regulator
B1K54_RS31930	COG2255	four-way junction helicase activity
B1K54_RS32045	COG0517	IMP dehydrogenase activity
B1K54_RS32045	COG0516	GMP reductase activity
B1K54_RS32070	COG0589	response to stress
B1K54_RS32120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B1K54_RS32120	COG0574	Belongs to the PEP-utilizing enzyme family
B1K54_RS32135	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B1K54_RS32145	COG1131	(ABC) transporter
B1K54_RS32155	COG0516	GMP reductase activity
B1K54_RS32155	COG0517	IMP dehydrogenase activity
B1K54_RS32160	COG0517	IMP dehydrogenase activity
B1K54_RS32160	COG0516	GMP reductase activity
B1K54_RS32170	COG0516	GMP reductase activity
B1K54_RS32170	COG0517	IMP dehydrogenase activity
B1K54_RS32185	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B1K54_RS32205	COG0517	IMP dehydrogenase activity
B1K54_RS32230	COG0022	dehydrogenase e1 component
B1K54_RS32230	COG0508	dehydrogenase complex catalyzes the overall conversion of
B1K54_RS32235	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B1K54_RS32240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1K54_RS32245	COG0517	IMP dehydrogenase activity
B1K54_RS32245	COG0516	GMP reductase activity
B1K54_RS32260	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
B1K54_RS32265	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B1K54_RS32270	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B1K54_RS32280	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B1K54_RS32285	COG2217	Heavy metal translocating P-type atpase
B1K54_RS32295	COG1131	(ABC) transporter
B1K54_RS32315	COG0569	domain protein
B1K54_RS32320	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B1K54_RS32325	COG1115	amino acid carrier protein
B1K54_RS32330	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B1K54_RS32335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1K54_RS32350	COG1278	Cold shock
B1K54_RS32355	COG0513	Belongs to the DEAD box helicase family
B1K54_RS32385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B1K54_RS32400	COG1247	-acetyltransferase
B1K54_RS32405	COG0640	Transcriptional regulator
B1K54_RS32425	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B1K54_RS32440	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B1K54_RS32445	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B1K54_RS32450	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
B1K54_RS32455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1K54_RS32465	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B1K54_RS32470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B1K54_RS32475	COG0534	Mate efflux family protein
B1K54_RS32485	COG0019	diaminopimelate decarboxylase activity
B1K54_RS32550	COG3173	Aminoglycoside phosphotransferase
B1K54_RS32570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B1K54_RS32575	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B1K54_RS32580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1K54_RS32590	COG2175	clavaminate synthase activity
B1K54_RS32605	COG1509	lysine 2,3-aminomutase activity
B1K54_RS32630	COG1132	(ABC) transporter
B1K54_RS32635	COG1132	(ABC) transporter
B1K54_RS32640	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B1K54_RS32650	COG0254	rRNA binding
B1K54_RS32660	COG0523	cobalamin synthesis protein
B1K54_RS32715	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B1K54_RS32730	COG0514	ATP-dependent DNA helicase (RecQ)
B1K54_RS32740	COG2226	methyltransferase
B1K54_RS32745	COG2205	protein histidine kinase activity
B1K54_RS32770	COG2226	methyltransferase
B1K54_RS32780	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B1K54_RS32795	COG0667	Aldo Keto reductase
B1K54_RS32815	COG0745	RESPONSE REGULATOR receiver
B1K54_RS32820	COG5002	protein histidine kinase activity
B1K54_RS32830	COG1982	Orn Lys Arg decarboxylase major
B1K54_RS32885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1K54_RS32890	COG2226	methyltransferase
B1K54_RS32900	COG1573	uracil-dna glycosylase
B1K54_RS32960	COG3486	L-lysine 6-monooxygenase (NADPH) activity
B1K54_RS32965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1K54_RS32970	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1K54_RS32975	COG1120	ATPase activity
B1K54_RS32980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B1K54_RS32985	COG1132	(ABC) transporter
B1K54_RS32995	COG1132	(ABC) transporter
B1K54_RS33000	COG2382	esterase
B1K54_RS33030	COG1191	sigma factor activity
B1K54_RS33085	COG1595	DNA-templated transcription, initiation
B1K54_RS33120	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B1K54_RS33185	COG0277	FAD linked oxidase domain protein
B1K54_RS33190	COG1309	transcriptional regulator
B1K54_RS33195	COG0667	Aldo Keto reductase
B1K54_RS33200	COG1309	transcriptional regulator
B1K54_RS33205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1K54_RS33260	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B1K54_RS33265	COG0346	lactoylglutathione lyase activity
B1K54_RS33275	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B1K54_RS33315	COG2909	trisaccharide binding
B1K54_RS33355	COG5297	Belongs to the glycosyl hydrolase family 6
B1K54_RS33355	COG4733	cellulase activity
B1K54_RS33405	COG0702	epimerase
B1K54_RS33430	COG0393	Putative heavy-metal-binding
B1K54_RS33435	COG2226	methyltransferase
B1K54_RS33460	COG2814	Major facilitator Superfamily
B1K54_RS33475	COG2356	endonuclease I
B1K54_RS33485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1K54_RS33515	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B1K54_RS33525	COG2815	serine threonine protein kinase
B1K54_RS33525	COG0515	serine threonine protein kinase
B1K54_RS33535	COG3953	SLT domain
B1K54_RS33535	COG5280	Phage tail tape measure protein TP901
B1K54_RS33540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B1K54_RS33575	COG1024	Enoyl-CoA hydratase
B1K54_RS33580	COG1028	Short-chain dehydrogenase reductase Sdr
B1K54_RS33595	COG1960	acyl-CoA dehydrogenase activity
B1K54_RS33600	COG1960	acyl-CoA dehydrogenase activity
B1K54_RS33620	COG2304	oxidoreductase activity
B1K54_RS33640	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B1K54_RS33650	COG2267	carboxylic ester hydrolase activity
B1K54_RS33670	COG1301	dicarboxylic acid transport
B1K54_RS33675	COG3290	protein histidine kinase activity
B1K54_RS33680	COG4565	transcriptional regulatory protein
B1K54_RS33700	COG0789	Transcriptional regulator
B1K54_RS33715	COG0076	glutamate decarboxylase activity
B1K54_RS33735	COG1414	Transcriptional regulator
B1K54_RS33740	COG0800	Aldolase
B1K54_RS33775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1K54_RS33780	COG1120	ATPase activity
B1K54_RS33800	COG0667	Aldo Keto reductase
B1K54_RS33815	COG1131	(ABC) transporter
B1K54_RS33820	COG1793	dna ligase
B1K54_RS33860	COG4412	M6 family metalloprotease domain protein
B1K54_RS33860	COG4412	M6 family metalloprotease domain protein
B1K54_RS33860	COG1404	Belongs to the peptidase S8 family
B1K54_RS33860	COG1404	Belongs to the peptidase S8 family
B1K54_RS33870	COG2124	cytochrome p450
B1K54_RS33880	COG3265	gluconokinase activity
B1K54_RS33895	COG1132	(ABC) transporter
B1K54_RS33925	COG2197	response regulator
B1K54_RS33930	COG4585	Histidine kinase
B1K54_RS33975	COG2226	methyltransferase
B1K54_RS33980	COG4264	IucA IucC family
B1K54_RS33985	COG4264	IucA IucC family
B1K54_RS33990	COG2188	Transcriptional regulator
B1K54_RS33995	COG2409	Drug exporters of the RND superfamily
B1K54_RS34000	COG4585	Histidine kinase
B1K54_RS34005	COG2197	response regulator
B1K54_RS34020	COG2226	methyltransferase
B1K54_RS34035	COG3973	AAA domain
B1K54_RS34080	COG3293	Transposase
B1K54_RS34165	COG0714	Associated with various cellular activities
B1K54_RS34170	COG3552	Protein containing von Willebrand factor type A (VWA) domain
B1K54_RS34185	COG2272	Belongs to the type-B carboxylesterase lipase family
B1K54_RS34200	COG1755	Isoprenylcysteine carboxyl methyltransferase
B1K54_RS34230	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B1K54_RS34230	COG1796	DNA polymerase
B1K54_RS34235	COG1846	Transcriptional regulator
B1K54_RS34240	COG1764	response to oxidative stress
B1K54_RS34265	COG1686	Belongs to the peptidase S11 family
B1K54_RS34280	COG0456	acetyltransferase
B1K54_RS34305	COG0318	PFAM AMP-dependent synthetase and ligase
B1K54_RS34350	COG1595	DNA-templated transcription, initiation
B1K54_RS34360	COG1278	Cold shock
B1K54_RS34365	COG0328	RNA-DNA hybrid ribonuclease activity
B1K54_RS34385	COG0515	serine threonine protein kinase
B1K54_RS34385	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B1K54_RS34390	COG0009	L-threonylcarbamoyladenylate synthase
B1K54_RS34410	COG4106	trans-aconitate 2-methyltransferase activity
B1K54_RS34445	COG2205	protein histidine kinase activity
B1K54_RS34450	COG0745	RESPONSE REGULATOR receiver
B1K54_RS34455	COG0477	Major facilitator Superfamily
B1K54_RS34465	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B1K54_RS34485	COG1191	sigma factor activity
B1K54_RS34520	COG0308	aminopeptidase N
B1K54_RS34535	COG3290	protein histidine kinase activity
B1K54_RS34625	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B1K54_RS34640	COG1024	Enoyl-CoA hydratase
B1K54_RS34650	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B1K54_RS34675	COG0477	Major facilitator Superfamily
B1K54_RS34680	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B1K54_RS34705	COG4977	sequence-specific DNA binding
B1K54_RS34765	COG5343	regulation of RNA biosynthetic process
B1K54_RS34780	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B1K54_RS34795	COG2409	Drug exporters of the RND superfamily
B1K54_RS34805	COG0038	chloride channel
B1K54_RS34840	COG0300	oxidoreductase activity
B1K54_RS34845	COG1309	transcriptional regulator
B1K54_RS34940	COG3631	Ketosteroid isomerase-related protein
B1K54_RS34945	COG0702	epimerase
B1K54_RS34975	COG1012	belongs to the aldehyde dehydrogenase family
B1K54_RS34985	COG0517	IMP dehydrogenase activity
B1K54_RS34985	COG4175	Glycine betaine
B1K54_RS34990	COG4176	ABC-type proline glycine betaine transport system permease component
B1K54_RS35030	COG1473	amidohydrolase
B1K54_RS35105	COG2226	methyltransferase
B1K54_RS35120	COG2409	Drug exporters of the RND superfamily
B1K54_RS35125	COG1028	Short-chain dehydrogenase reductase Sdr
B1K54_RS35150	COG1725	Transcriptional regulator
B1K54_RS35170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1K54_RS35180	COG0730	response to heat
B1K54_RS35185	COG1937	Protein conserved in bacteria
B1K54_RS35200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B1K54_RS35310	COG1309	transcriptional regulator
B1K54_RS35405	COG0515	serine threonine protein kinase
B1K54_RS35405	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane