locus-tag class description HKX69_RS00110 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HKX69_RS00130 ENOG4105MWK D-amino acid dehydrogenase, small subunit HKX69_RS00135 ENOG4105ETE Transcriptional regulator (LacI family HKX69_RS00145 ENOG4105DRP amino acid AbC transporter HKX69_RS00150 ENOG4105E89 ABC transporter HKX69_RS00190 ENOG4105C26 Dehydrogenase HKX69_RS00225 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HKX69_RS00280 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HKX69_RS00295 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HKX69_RS00305 ENOG4105E2A Dehydrogenase HKX69_RS00325 ENOG4108YV4 Universal stress protein HKX69_RS00340 ENOG41080XP Cbs domain HKX69_RS00370 ENOG4107SHJ sulfite reductase subunit b HKX69_RS00380 ENOG4105E2A Dehydrogenase HKX69_RS00390 ENOG4105C2X Arabinose 5-phosphate isomerase HKX69_RS00400 ENOG4108KQ5 Integrase catalytic subunit HKX69_RS00425 ENOG4105CIR epoxide hydrolase HKX69_RS00450 ENOG4105RNG membrane HKX69_RS00455 ENOG4105K6V RNA polymerase HKX69_RS00470 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HKX69_RS00480 ENOG4105CXN decarboxylase HKX69_RS00490 ENOG4105CUB amino acid HKX69_RS00520 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HKX69_RS00525 ENOG4107MMM Anti-sigma-factor antagonist HKX69_RS00535 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HKX69_RS00545 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HKX69_RS00570 ENOG4105WN5 stage II sporulation protein HKX69_RS00580 ENOG41082AN stage II sporulation protein HKX69_RS00590 ENOG4105EC3 peptidase S51, dipeptidase E HKX69_RS00625 ENOG4105DJI Methylaspartate mutase, E subunit HKX69_RS00630 ENOG4105C5S asparaginyl-tRNA synthetase HKX69_RS00635 ENOG4105CBC glutamate synthase HKX69_RS00645 ENOG4105CIF Ornithine Cyclodeaminase HKX69_RS00685 ENOG4105GTG Isochorismatase HKX69_RS00695 ENOG4105M4P Tetr family transcriptional regulator HKX69_RS00700 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HKX69_RS00710 ENOG41060BG Tetr family transcriptional regulator HKX69_RS00715 ENOG4107QN2 dihydrolipoyl dehydrogenase HKX69_RS00720 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HKX69_RS00735 ENOG4105CS1 NAD(P)H quinone oxidoreductase HKX69_RS00740 ENOG4106NZI LysR family Transcriptional regulator HKX69_RS00745 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HKX69_RS00765 ENOG4105CWX Alpha-1,2-mannosidase HKX69_RS00780 ENOG4105EMU Dehydrogenase HKX69_RS00815 ENOG4108KEZ Dehydrogenase HKX69_RS00820 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HKX69_RS00825 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HKX69_RS00865 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein HKX69_RS00870 ENOG4108XDN Transcriptional regulator HKX69_RS00890 ENOG4106UW1 Major Facilitator superfamily HKX69_RS00895 ENOG4105E98 transcriptional regulator DeoR family HKX69_RS00915 ENOG4105VEQ Cold shock protein HKX69_RS00920 ENOG4105CIR epoxide hydrolase HKX69_RS00930 ENOG4105CBP Major Facilitator HKX69_RS00935 ENOG4105CPC Aldo Keto reductase HKX69_RS00940 ENOG4105CHR reductase HKX69_RS00965 ENOG4105VDT -acetyltransferase HKX69_RS01030 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HKX69_RS01035 ENOG4105WH1 Two component transcriptional regulator luxr family HKX69_RS01040 ENOG4105BZU Histidine kinase HKX69_RS01050 ENOG4105SCY DNAK suppressor HKX69_RS01085 ENOG4105CVN desaturase HKX69_RS01110 ENOG4105I1F Resistance protein HKX69_RS01125 ENOG41068WN HKX69_RS01130 ENOG4108Z6Z Transcriptional regulator HKX69_RS01150 ENOG4107RCH Diaminopropionate ammonia-lyase HKX69_RS01160 ENOG4105ETE Transcriptional regulator (LacI family HKX69_RS01175 ENOG4105DRS transport system, permease HKX69_RS01220 ENOG4105CAY ferredoxin--nadp reductase HKX69_RS01225 ENOG4105CEY Amp-dependent synthetase and ligase HKX69_RS01230 ENOG4108UW5 maltose o-acetyltransferase HKX69_RS01245 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HKX69_RS01250 ENOG4108UHU Aldolase HKX69_RS01260 ENOG4105CXK mandelate racemase muconate lactonizing HKX69_RS01265 ENOG4105JXH GntR family transcriptional regulator HKX69_RS01280 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HKX69_RS01285 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HKX69_RS01295 ENOG4105EX0 alpha-galactosidase HKX69_RS01305 ENOG4108KXM LysR family Transcriptional regulator HKX69_RS01310 ENOG4105S7M extracellular small neutral protease HKX69_RS01320 ENOG4107SVN transposase HKX69_RS01325 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HKX69_RS01330 ENOG4105EHG Permease protein HKX69_RS01390 ENOG4107RSM transcriptional regulator HKX69_RS01415 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HKX69_RS01450 ENOG4105CGS Alpha-glucosidase HKX69_RS01470 ENOG410880H cysteine synthase HKX69_RS01490 ENOG4105CPN adenine deaminase HKX69_RS01495 ENOG4105CHJ isochorismatase hydrolase HKX69_RS01500 ENOG4108VGI doxx family HKX69_RS01505 ENOG4105XPP Protein of unknown function (DUF1275) HKX69_RS01515 ENOG4107SFI Major Facilitator superfamily HKX69_RS01520 ENOG4105C7K acetolactate synthase HKX69_RS01525 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HKX69_RS01555 ENOG4105KF0 sporulation and cell division protein, SsgA HKX69_RS01590 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HKX69_RS01640 ENOG4105EYF MMPL domain protein HKX69_RS01650 ENOG41064MX Tetr family transcriptional regulator HKX69_RS01655 ENOG4105F27 Major Facilitator HKX69_RS01670 ENOG4108TM9 integral membrane protein HKX69_RS01675 ENOG4107TB5 TRANSCRIPTIONal HKX69_RS01680 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HKX69_RS01700 ENOG4107TE5 Lipid kinase HKX69_RS01705 ENOG4107R3A FAD linked oxidase domain protein HKX69_RS01725 ENOG4105CHR reductase HKX69_RS01745 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HKX69_RS01760 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HKX69_RS01765 ENOG4107TYH extracellular solute-binding protein family 1 HKX69_RS01770 ENOG4105D81 ABC transporter, permease HKX69_RS01775 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HKX69_RS01800 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HKX69_RS01815 ENOG4107SVN transposase HKX69_RS01820 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HKX69_RS01830 ENOG4108VQR secreted hydrolase HKX69_RS01880 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HKX69_RS01895 ENOG4105CUB amino acid HKX69_RS01920 ENOG4108KB2 LysR family Transcriptional regulator HKX69_RS01930 ENOG4105WH1 Two component transcriptional regulator luxr family HKX69_RS01935 ENOG4105ENE Histidine kinase HKX69_RS01980 ENOG4107MMM Anti-sigma-factor antagonist HKX69_RS01985 ENOG4105FUA antagonist HKX69_RS01990 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HKX69_RS02010 ENOG4105CXN decarboxylase HKX69_RS02030 ENOG4105EGE secreted protein HKX69_RS02065 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HKX69_RS02095 ENOG4106A3M Cytochrome p-450 HKX69_RS02105 ENOG4107SET aldo keto reductase HKX69_RS02185 ENOG4108ZBR Gcn5-related n-acetyltransferase HKX69_RS02235 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HKX69_RS02250 ENOG4105BZP glycoside hydrolase 15-related HKX69_RS02340 ENOG4105CAQ asparagine synthetase HKX69_RS02360 ENOG41067SE Tetr family transcriptional regulator HKX69_RS02390 ENOG4105E2R ROK family HKX69_RS02415 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HKX69_RS02440 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HKX69_RS02455 ENOG4105BZ9 Cytochrome C oxidase, subunit I HKX69_RS02485 ENOG4105XRQ Xanthine dehydrogenase accessory factor HKX69_RS02500 ENOG4108W6C Dehydrogenase HKX69_RS02510 ENOG41080V3 Major Facilitator superfamily HKX69_RS02550 ENOG41085A6 mbth domain-containing protein HKX69_RS02570 ENOG4106A3M Cytochrome p-450 HKX69_RS02600 ENOG4108JJA ABC, transporter HKX69_RS02620 ENOG4108ZJ4 polysaccharide deacetylase HKX69_RS02630 ENOG4105EMU Dehydrogenase HKX69_RS02650 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HKX69_RS02670 ENOG4105DMF Dehydrogenase HKX69_RS02690 ENOG4105CNT hydrolase family 2 HKX69_RS02700 ENOG4105DU6 RNA polymerase HKX69_RS02705 ENOG4108V5V Serine Threonine protein kinase HKX69_RS02735 ENOG4105CPC Aldo Keto reductase HKX69_RS02750 ENOG4106YKD Cytochrome p-450 HKX69_RS02770 ENOG4105CHF Glutathione S-transferase HKX69_RS02795 ENOG4105ECQ AraC Family Transcriptional Regulator HKX69_RS02805 ENOG4105WN5 stage II sporulation protein HKX69_RS02815 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HKX69_RS02820 ENOG4105MKQ Monovalent cation H antiporter subunit C HKX69_RS02865 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HKX69_RS02870 ENOG4105DCG PHP domain protein HKX69_RS02875 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HKX69_RS02890 ENOG4105E2R ROK family HKX69_RS02920 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HKX69_RS02940 ENOG4108R86 Transcriptional regulator HKX69_RS02945 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HKX69_RS02950 ENOG4105DDN Pentapeptide repeat-containing protein HKX69_RS02965 ENOG4105ETE Transcriptional regulator (LacI family HKX69_RS02975 ENOG4105D4B ABC, transporter HKX69_RS02980 ENOG4105F5R ABC transporter HKX69_RS02985 ENOG4105CNN ABC, transporter HKX69_RS02990 ENOG4105C2J ABC transporter HKX69_RS02995 ENOG4105C9F isomerase HKX69_RS03005 ENOG4105DET Rhamnulokinase HKX69_RS03010 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HKX69_RS03020 ENOG41080R8 Conserved Protein HKX69_RS03025 ENOG4108IJ8 ABC transporter HKX69_RS03040 ENOG4105E90 ABC transporter HKX69_RS03050 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HKX69_RS03100 ENOG4105G6Z alkaline phosphatase HKX69_RS03120 ENOG4105WH1 Two component transcriptional regulator luxr family HKX69_RS03180 ENOG4105CJQ hydrolase, family 31 HKX69_RS03185 ENOG4108JE9 extracellular solute-binding protein family 1 HKX69_RS03195 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HKX69_RS03210 ENOG4105BZU Histidine kinase HKX69_RS03215 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HKX69_RS03250 ENOG4105CH6 catalase HKX69_RS03295 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HKX69_RS03305 ENOG41080RH Thioredoxin HKX69_RS03310 ENOG4105ETE Transcriptional regulator (LacI family HKX69_RS03320 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HKX69_RS03350 ENOG4105DZ6 Band 7 protein HKX69_RS03385 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process HKX69_RS03390 ENOG4108V75 Glutamine amidotransferase HKX69_RS03395 ENOG41067HS methyltransferase HKX69_RS03405 ENOG4105WKW Pfam:DUF1458 HKX69_RS03415 ENOG4105DEN Luciferase family HKX69_RS03445 ENOG4105E33 succinate dehydrogenase HKX69_RS03460 ENOG4105C5Q Transcriptional regulator HKX69_RS03470 ENOG4107RSM transcriptional regulator HKX69_RS03475 ENOG4105BZU Histidine kinase HKX69_RS03510 ENOG4108ZJ4 polysaccharide deacetylase HKX69_RS03520 ENOG4105CUB amino acid HKX69_RS03585 ENOG4105DIA mandelate racemase muconate lactonizing HKX69_RS03595 ENOG4105C2J ABC transporter HKX69_RS03600 ENOG4105DFW ABC transporter HKX69_RS03615 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HKX69_RS03640 ENOG4105CWX Alpha-1,2-mannosidase HKX69_RS03645 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HKX69_RS03650 ENOG4107QPH glycogen) synthase HKX69_RS03670 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HKX69_RS03680 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HKX69_RS03690 ENOG4105VN1 Heat shock protein HKX69_RS03715 ENOG4105C02 permease HKX69_RS03740 ENOG4107RN3 metallophosphoesterase HKX69_RS03760 ENOG4108VHC Short-chain dehydrogenase reductase Sdr HKX69_RS03765 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HKX69_RS03780 ENOG4108NEV two component transcriptional regulator, LytTR family HKX69_RS03795 ENOG4105C7W Xanthine dehydrogenase HKX69_RS03800 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HKX69_RS03805 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HKX69_RS03810 ENOG4105EGE secreted protein HKX69_RS03815 ENOG4105BZ1 (ABC) transporter HKX69_RS03825 ENOG4105E39 Enoyl-CoA hydratase HKX69_RS03835 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein HKX69_RS03840 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HKX69_RS03850 ENOG4105CUB amino acid HKX69_RS03855 ENOG4105D64 Mechanosensitive ion channel HKX69_RS03860 ENOG4105M0C cytoplasmic protein HKX69_RS03865 ENOG4105E9K Isocitrate dehydrogenase HKX69_RS03900 ENOG4105E2A Dehydrogenase HKX69_RS03915 ENOG4106S2D Transcriptional regulator HKX69_RS03930 ENOG4105DEN Luciferase family HKX69_RS03945 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HKX69_RS03950 ENOG4105EAB amino acid AbC transporter HKX69_RS03955 ENOG4105CDA abc transporter atp-binding protein HKX69_RS03970 ENOG4105MWK D-amino acid dehydrogenase, small subunit HKX69_RS03980 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein HKX69_RS03985 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HKX69_RS03990 ENOG4105CTU Proline racemase HKX69_RS04000 ENOG4105D5Q Arginine ornithine antiporter HKX69_RS04005 ENOG4108HRK Histidine kinase HKX69_RS04020 ENOG4108NEV two component transcriptional regulator, LytTR family HKX69_RS04030 ENOG4105CMR udp-glucose 4-epimerase HKX69_RS04040 ENOG4105C0R drug resistance transporter emrb qaca subfamily HKX69_RS04060 ENOG4105ETE Transcriptional regulator (LacI family HKX69_RS04065 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HKX69_RS04070 ENOG4105ETE Transcriptional regulator (LacI family HKX69_RS04080 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HKX69_RS04100 ENOG4105C2J ABC transporter HKX69_RS04105 ENOG4105CNN ABC, transporter HKX69_RS04115 ENOG4105FDP GntR family transcriptional regulator HKX69_RS04120 ENOG4105EPJ extracellular solute-binding protein family 1 HKX69_RS04170 ENOG4105ETE Transcriptional regulator (LacI family HKX69_RS04180 ENOG4107T94 Endo-14-beta-xylanase HKX69_RS04185 ENOG4107T94 Endo-14-beta-xylanase HKX69_RS04230 ENOG4105CEY Amp-dependent synthetase and ligase HKX69_RS04240 ENOG4105E5G Alpha beta hydrolase fold HKX69_RS04265 ENOG4108HCJ Hydrolase HKX69_RS04330 ENOG4106NZI LysR family Transcriptional regulator HKX69_RS04335 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HKX69_RS04340 ENOG4105CPQ Dehydrogenase HKX69_RS04375 ENOG4105D82 Glutamate dehydrogenase HKX69_RS04385 ENOG41090WU lipolytic protein G-D-S-L family HKX69_RS04425 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HKX69_RS04440 ENOG4105EWU Squalene--hopene cyclase HKX69_RS04460 ENOG4105FBD synthase HKX69_RS04465 ENOG4105EY8 ABC transporter HKX69_RS04485 ENOG4108MDK Dehydrogenase HKX69_RS04510 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HKX69_RS04520 ENOG41060WC Enoyl-CoA hydratase HKX69_RS04535 ENOG4105BZM domain protein HKX69_RS04560 ENOG4108U3T pfkb domain protein HKX69_RS04575 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HKX69_RS04580 ENOG4105CHU acetyl-coa acetyltransferase HKX69_RS04585 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HKX69_RS04590 ENOG4105EG6 Saccharopine dehydrogenase HKX69_RS04595 ENOG4108KQ5 Integrase catalytic subunit HKX69_RS04600 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HKX69_RS04625 ENOG4105C5H ABC transporter HKX69_RS04630 ENOG4106V2I dimethylaminohydrolase HKX69_RS04640 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HKX69_RS04650 ENOG4105ETE Transcriptional regulator (LacI family HKX69_RS04655 ENOG4105DQE DNA ligase HKX69_RS04675 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HKX69_RS04680 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HKX69_RS04685 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HKX69_RS04695 ENOG4107SM8 Adenylate Guanylate cyclase HKX69_RS04735 ENOG4105CG3 alpha amylase, catalytic region HKX69_RS04745 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HKX69_RS04795 ENOG4106UDK Cellulose-binding, family II HKX69_RS04815 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HKX69_RS04830 ENOG4107QP8 phosphohexose isomerase HKX69_RS04835 ENOG4108J5G 6-phosphogluconate dehydrogenase HKX69_RS04840 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HKX69_RS04865 ENOG410905P Pyridoxamine 5-phosphate HKX69_RS04900 ENOG4107QJN gtp cyclohydrolase ii HKX69_RS04920 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HKX69_RS04995 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HKX69_RS05020 ENOG4105C26 Dehydrogenase HKX69_RS05030 ENOG4105CMV Succinyl-CoA synthetase subunit beta HKX69_RS05050 ENOG4105FCD Major Facilitator HKX69_RS05065 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HKX69_RS05075 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HKX69_RS05080 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HKX69_RS05085 ENOG4107QIZ NADH dehydrogenase HKX69_RS05095 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HKX69_RS05100 ENOG4105D3W isochorismatase HKX69_RS05105 ENOG4108VHT MarR family transcriptional regulator HKX69_RS05115 ENOG4108478 ec 3.2.1.18 HKX69_RS05120 ENOG4105DHU Bile acid HKX69_RS05125 ENOG4105DUM transcriptional regulator, lysR family HKX69_RS05135 ENOG4105CV8 reductase HKX69_RS05150 ENOG4105EMU Dehydrogenase HKX69_RS05155 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HKX69_RS05165 ENOG41065HY 1,4-beta-cellobiosidase HKX69_RS05175 ENOG4105CYP glycoside hydrolase, family HKX69_RS05200 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HKX69_RS05205 ENOG410842T Pterin carbinolamine dehydratase HKX69_RS05240 ENOG4105E8R UPF0173 metal-dependent hydrolase HKX69_RS05280 ENOG4108Z0Z intracellular protease Pfpi family HKX69_RS05295 ENOG4105C5H ABC transporter HKX69_RS05315 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) HKX69_RS05325 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) HKX69_RS05350 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth HKX69_RS05360 ENOG4105DQE DNA ligase HKX69_RS05395 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HKX69_RS05405 ENOG4108KQ5 Integrase catalytic subunit HKX69_RS05410 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HKX69_RS05415 ENOG4108ME1 Peptidase M55 D-aminopeptidase HKX69_RS05420 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HKX69_RS05425 ENOG4108Q50 Histidine kinase HKX69_RS05445 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HKX69_RS05455 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HKX69_RS05475 ENOG4105CI0 Citrate lyase HKX69_RS05485 ENOG4105C1G acyl-Coa dehydrogenase HKX69_RS05490 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme HKX69_RS05500 ENOG4105BZW Glycerate kinase HKX69_RS05515 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HKX69_RS05530 ENOG4105DAE Methylenetetrahydrofolate reductase HKX69_RS05600 ENOG4107V6K Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) HKX69_RS05610 ENOG4107VC8 ATP cone domain protein HKX69_RS05765 ENOG4108FKH Transglycosylase SLT domain HKX69_RS05975 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) HKX69_RS05985 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HKX69_RS05995 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) HKX69_RS06010 ENOG4105C8Y Acetylornithine aminotransferase HKX69_RS06030 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HKX69_RS06035 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HKX69_RS06065 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HKX69_RS06095 ENOG4105VBF alkaline shock protein HKX69_RS06135 ENOG4105EPW hflc protein HKX69_RS06140 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HKX69_RS06240 ENOG4105CH2 amidohydrolase HKX69_RS06255 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HKX69_RS06260 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HKX69_RS06265 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HKX69_RS06340 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HKX69_RS06370 ENOG4105ERH Fumarylacetoacetate hydrolase HKX69_RS06375 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase HKX69_RS06380 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HKX69_RS06390 ENOG4105CN5 Metallo-Beta-Lactamase HKX69_RS06435 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HKX69_RS06445 ENOG4105CIS alcohol dehydrogenase HKX69_RS06450 ENOG4108KPJ rna polymerase sigma factor HKX69_RS06470 ENOG4105C9U ATP-dependent DNA helicase RecQ HKX69_RS06480 ENOG4105F27 Major Facilitator HKX69_RS06495 ENOG4105C0D helicase HKX69_RS06505 ENOG4105DKQ ROK family HKX69_RS06510 ENOG4105C2J ABC transporter HKX69_RS06530 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HKX69_RS06540 ENOG4105WH1 Two component transcriptional regulator luxr family HKX69_RS06580 ENOG4107HP6 Transcriptional regulator HKX69_RS06600 ENOG4107R9S Malate synthase HKX69_RS06645 ENOG4105CHM Aminotransferase HKX69_RS06660 ENOG4108ZM9 phosphoglycerate mutase HKX69_RS06695 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HKX69_RS06700 ENOG4105C2W permease HKX69_RS06710 ENOG4105VT2 5-hydroxyisourate hydrolase HKX69_RS06730 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HKX69_RS06735 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HKX69_RS06740 ENOG4105CH6 catalase HKX69_RS06755 ENOG41060W2 glyoxylate carboligase HKX69_RS06765 ENOG4105CEY Amp-dependent synthetase and ligase HKX69_RS06770 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HKX69_RS06785 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HKX69_RS06800 ENOG4108ZJ4 polysaccharide deacetylase HKX69_RS06815 ENOG410829K Lysine exporter protein (Lyse ygga) HKX69_RS06825 ENOG4105C7N Xanthine uracil vitamin C permease HKX69_RS06830 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HKX69_RS06855 ENOG4105DRR Transcriptional regulator, GntR family HKX69_RS06875 ENOG4105C7K acetolactate synthase HKX69_RS06895 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HKX69_RS06905 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HKX69_RS06910 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HKX69_RS06955 ENOG4108J5H Homocysteine s-methyltransferase HKX69_RS06960 ENOG4105EBR Carboxylesterase HKX69_RS06970 ENOG4105CR4 methylisocitrate lyase HKX69_RS07000 ENOG4105CSU acyl-Coa dehydrogenase HKX69_RS07005 ENOG4107RR1 TRANSCRIPTIONal HKX69_RS07030 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HKX69_RS07060 ENOG4105D7T ABC transporter HKX69_RS07065 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HKX69_RS07080 ENOG4105GSW HKX69_RS07120 ENOG4105MC2 DSBA oxidoreductase HKX69_RS07125 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HKX69_RS07130 ENOG4107R13 MMPL domain protein HKX69_RS07150 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HKX69_RS07170 ENOG4105F11 amine oxidase HKX69_RS07190 ENOG4105DND Transcriptional regulator HKX69_RS07240 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein HKX69_RS07260 ENOG41064MX Tetr family transcriptional regulator HKX69_RS07295 ENOG41082SX arsR family transcriptional regulator HKX69_RS07305 ENOG4105C84 Histidine ammonia-lyase HKX69_RS07310 ENOG4108HQR Glycine betaine HKX69_RS07320 ENOG4105GWZ Roadblock lc7 family protein HKX69_RS07335 ENOG4105E90 ABC transporter HKX69_RS07340 ENOG4105E90 ABC transporter HKX69_RS07345 ENOG4108IJ8 ABC transporter HKX69_RS07350 ENOG4105E0X reductase HKX69_RS07355 ENOG4105DFU Cell wall formation (By similarity) HKX69_RS07375 ENOG4108KQ5 Integrase catalytic subunit HKX69_RS07385 ENOG4107B2H carbonic anhydrase HKX69_RS07400 ENOG4105CSR polyphosphate kinase 2 HKX69_RS07425 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HKX69_RS07435 ENOG4105E18 UPF0276 protein HKX69_RS07455 ENOG4107JTW chlorite dismutase HKX69_RS07460 ENOG4105C1Q protoporphyrinogen oxidase HKX69_RS07470 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HKX69_RS07485 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HKX69_RS07500 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HKX69_RS07505 ENOG4105CHU acetyl-coa acetyltransferase HKX69_RS07510 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HKX69_RS07535 ENOG4105CUB amino acid HKX69_RS07540 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HKX69_RS07545 ENOG4108HWW ABC transporter HKX69_RS07550 ENOG4105C2J ABC transporter HKX69_RS07555 ENOG4105DFW ABC transporter HKX69_RS07560 ENOG4105E2R ROK family HKX69_RS07590 ENOG4105CWX Alpha-1,2-mannosidase HKX69_RS07595 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HKX69_RS07600 ENOG4105CFG Acts as a chaperone (By similarity) HKX69_RS07605 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HKX69_RS07610 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HKX69_RS07615 ENOG4107QM5 aconitate hydratase HKX69_RS07620 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HKX69_RS07625 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) HKX69_RS07690 ENOG4105D17 glycoside hydrolase, family 3 domain protein HKX69_RS07710 ENOG4105FDP GntR family transcriptional regulator HKX69_RS07740 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HKX69_RS07745 ENOG4105CGU Enoyl-CoA hydratase HKX69_RS07755 ENOG4105CUB amino acid HKX69_RS07760 ENOG4105DBV ornithine carbamoyltransferase HKX69_RS07765 ENOG4105CEU Arginine dihydrolase HKX69_RS07810 ENOG4107S1Q Phosphatase HKX69_RS07870 ENOG4108YYC ycei family HKX69_RS07895 ENOG4105D3Q Sugar transferase HKX69_RS07900 ENOG4105C6Y Udp-glucose 6-dehydrogenase HKX69_RS07920 ENOG4105CAQ asparagine synthetase HKX69_RS07925 ENOG4107RRD Dehydrogenase HKX69_RS07945 ENOG4105CPK Glycosyl transferase (Group 1 HKX69_RS07955 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HKX69_RS07970 ENOG4105EQQ protein containing aminopeptidase domain HKX69_RS07980 ENOG4105K64 Glycosyl transferase, family 2 HKX69_RS07990 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HKX69_RS07995 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HKX69_RS08040 ENOG4105CIK Amidinotransferase HKX69_RS08075 ENOG4105CEY Amp-dependent synthetase and ligase HKX69_RS08085 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HKX69_RS08115 ENOG4105CEY Amp-dependent synthetase and ligase HKX69_RS08120 ENOG4105CPQ Dehydrogenase HKX69_RS08125 ENOG4105EV8 ectoine hydroxylase HKX69_RS08140 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HKX69_RS08185 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HKX69_RS08190 ENOG4105C0X amino acid HKX69_RS08200 ENOG4107VEG TrkA-N domain protein HKX69_RS08230 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HKX69_RS08240 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HKX69_RS08265 ENOG4106F60 Histidine kinase HKX69_RS08270 ENOG4105F44 Two component transcriptional regulator, winged helix family HKX69_RS08285 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HKX69_RS08320 ENOG4107W53 thymidine kinase HKX69_RS08340 ENOG410849S phosphocarrier protein (HPr) HKX69_RS08345 ENOG4105DRR Transcriptional regulator, GntR family HKX69_RS08365 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HKX69_RS08370 ENOG4105CKI cobalamin synthesis protein HKX69_RS08375 ENOG4105BZN citrate synthase HKX69_RS08380 ENOG4105BZN citrate synthase HKX69_RS08395 ENOG4108V9W transcriptional regulatory protein HKX69_RS08405 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component HKX69_RS08415 ENOG4108MRH transcriptional regulatory protein HKX69_RS08420 ENOG4107QN1 sodium solute HKX69_RS08430 ENOG4105WH1 Two component transcriptional regulator luxr family HKX69_RS08445 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HKX69_RS08460 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HKX69_RS08465 ENOG4105DRR Transcriptional regulator, GntR family HKX69_RS08490 ENOG4105C9U ATP-dependent DNA helicase RecQ HKX69_RS08505 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HKX69_RS08525 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HKX69_RS08540 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HKX69_RS08545 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HKX69_RS08550 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HKX69_RS08580 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HKX69_RS08590 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HKX69_RS08595 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HKX69_RS08605 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HKX69_RS08625 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HKX69_RS08645 ENOG4106UDK Cellulose-binding, family II HKX69_RS08665 ENOG4105H1G trap transporter solute receptor taxi family HKX69_RS08670 ENOG4105EB3 Histidine kinase HKX69_RS08675 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HKX69_RS08680 ENOG4105CDA abc transporter atp-binding protein HKX69_RS08685 ENOG4107UBR Extracellular solute-binding protein family 3 HKX69_RS08690 ENOG4108Q1T ABC transporter HKX69_RS08695 ENOG4105DRP amino acid AbC transporter HKX69_RS08700 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase HKX69_RS08725 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HKX69_RS08740 ENOG4105DSF transport protein HKX69_RS08760 ENOG4107QRT dEAD DEAH box helicase HKX69_RS08765 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HKX69_RS08775 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HKX69_RS08780 ENOG4105WBV Transcriptional regulator HKX69_RS08785 ENOG4105CEV competence damage-inducible protein HKX69_RS08795 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HKX69_RS08810 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HKX69_RS08815 ENOG4105BZU Histidine kinase HKX69_RS08850 ENOG4105CN5 Metallo-Beta-Lactamase HKX69_RS08855 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HKX69_RS08860 ENOG4107V6K Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) HKX69_RS08880 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HKX69_RS08885 ENOG4105C1V Peptidase, M16 HKX69_RS08890 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HKX69_RS08895 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HKX69_RS08910 ENOG4105EC2 ftsk spoIIIe HKX69_RS08960 ENOG4108PZM peptidase S8 and S53, subtilisin, kexin, sedolisin HKX69_RS08965 ENOG4108T50 Protein of unknown function (DUF690) HKX69_RS09000 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HKX69_RS09005 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HKX69_RS09015 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HKX69_RS09030 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) HKX69_RS09045 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase HKX69_RS09050 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HKX69_RS09055 ENOG4108Z7F N-acetyltransferase HKX69_RS09065 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HKX69_RS09070 ENOG4105DZP Membrane-associated zinc metalloprotease HKX69_RS09075 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HKX69_RS09090 ENOG4105ETE Transcriptional regulator (LacI family HKX69_RS09100 ENOG4105C26 Dehydrogenase HKX69_RS09140 ENOG4108KQ5 Integrase catalytic subunit HKX69_RS09145 ENOG4105CJP fad dependent oxidoreductase HKX69_RS09150 ENOG4105D38 putrescine abc transporter HKX69_RS09155 ENOG4105F38 ABC transporter, permease HKX69_RS09160 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HKX69_RS09185 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HKX69_RS09190 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HKX69_RS09210 ENOG4107HP6 Transcriptional regulator HKX69_RS09230 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HKX69_RS09240 ENOG4105C26 Dehydrogenase HKX69_RS09250 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HKX69_RS09255 ENOG4108I0Y (ABC) transporter HKX69_RS09285 ENOG4108UCS ABC, transporter HKX69_RS09290 ENOG4105ECW sulfate abc transporter HKX69_RS09300 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HKX69_RS09310 ENOG4106A3M Cytochrome p-450 HKX69_RS09315 ENOG4105KNE Phosphatidate cytidylyltransferase HKX69_RS09320 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HKX69_RS09325 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HKX69_RS09330 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HKX69_RS09335 ENOG4105CE9 30S ribosomal protein S2 HKX69_RS09350 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HKX69_RS09385 ENOG41080R2 UPF0102 protein HKX69_RS09395 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HKX69_RS09405 ENOG4107QYR Signal peptidase i HKX69_RS09420 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HKX69_RS09425 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HKX69_RS09430 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HKX69_RS09435 ENOG41082KU UPF0109 protein HKX69_RS09440 ENOG4105K5M 30s ribosomal protein S16 HKX69_RS09460 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HKX69_RS09470 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HKX69_RS09515 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HKX69_RS09525 ENOG4108375 Acylphosphatase (EC 3.6.1.7) HKX69_RS09535 ENOG4105CS1 NAD(P)H quinone oxidoreductase HKX69_RS09540 ENOG4105KVH Transcriptional regulator HKX69_RS09545 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HKX69_RS09550 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HKX69_RS09555 ENOG41084BZ 50S ribosomal protein L32 HKX69_RS09570 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HKX69_RS09575 ENOG4106H78 methyltransferase HKX69_RS09595 ENOG4105DP4 dak2 domain fusion protein ylov HKX69_RS09600 ENOG4105VB9 50S ribosomal protein l28 HKX69_RS09605 ENOG4105DWF phosphomethylpyrimidine kinase HKX69_RS09625 ENOG4105CPF Cell wall formation (By similarity) HKX69_RS09630 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HKX69_RS09650 ENOG4105K70 DNA-binding protein HKX69_RS09660 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HKX69_RS09665 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HKX69_RS09670 ENOG41069M3 Transcriptional regulator HKX69_RS09730 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HKX69_RS09735 ENOG4105ERH Fumarylacetoacetate hydrolase HKX69_RS09750 ENOG4105GWZ Roadblock lc7 family protein HKX69_RS09770 ENOG4105GWZ Roadblock lc7 family protein HKX69_RS09785 ENOG4105F9F transposase HKX69_RS09795 ENOG4105D8K carboxyl transferase HKX69_RS09800 ENOG4106AM8 polysaccharide lyase family 8 HKX69_RS09810 ENOG4108YYC ycei family HKX69_RS09835 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HKX69_RS09860 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HKX69_RS09865 ENOG4105CSH Transporter HKX69_RS09875 ENOG4105DWY Agmatine deiminase HKX69_RS09880 ENOG4105CQM Urea amidohydrolase subunit alpha HKX69_RS09890 ENOG4105CM2 brancheD-chain amino acid aminotransferase HKX69_RS09895 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HKX69_RS09910 ENOG4105C26 Dehydrogenase HKX69_RS09930 ENOG4105C57 major facilitator superfamily HKX69_RS09935 ENOG4108JQ1 Dehydrogenase HKX69_RS09940 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HKX69_RS09945 ENOG4108ZP8 Acetolactate synthase small subunit HKX69_RS09965 ENOG4105CPC Aldo Keto reductase HKX69_RS09980 ENOG4105WH1 Two component transcriptional regulator luxr family HKX69_RS09995 ENOG4105D9U N-acetyltransferase HKX69_RS10005 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HKX69_RS10015 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HKX69_RS10020 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HKX69_RS10040 ENOG4105BZU Histidine kinase HKX69_RS10045 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HKX69_RS10055 ENOG4105EMU Dehydrogenase HKX69_RS10060 ENOG4108URH decarboxylase HKX69_RS10075 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HKX69_RS10105 ENOG4105D29 Helix-turn-helix type 11 domain protein HKX69_RS10125 ENOG4105EN6 Membrane HKX69_RS10135 ENOG4108JQ7 (ABC) transporter HKX69_RS10155 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HKX69_RS10175 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HKX69_RS10180 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HKX69_RS10185 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HKX69_RS10190 ENOG4105EJQ L-serine dehydratase HKX69_RS10205 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) HKX69_RS10210 ENOG4105DKW ABC transporter HKX69_RS10250 ENOG4105S7A ErfK ybiS ycfS ynhG family protein HKX69_RS10255 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HKX69_RS10290 ENOG4105BZ1 (ABC) transporter HKX69_RS10295 ENOG4105BZ1 (ABC) transporter HKX69_RS10300 ENOG4105BZ1 (ABC) transporter HKX69_RS10305 ENOG4105BZ1 (ABC) transporter HKX69_RS10345 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HKX69_RS10360 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HKX69_RS10370 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) HKX69_RS10375 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HKX69_RS10395 ENOG4105C57 major facilitator superfamily HKX69_RS10405 ENOG4107QJT sodium dicarboxylate symporter HKX69_RS10410 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HKX69_RS10415 ENOG4108V9W transcriptional regulatory protein HKX69_RS10430 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HKX69_RS10460 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HKX69_RS10475 ENOG4105CTQ phosphohexokinase HKX69_RS10480 ENOG4105C6K Malic enzyme HKX69_RS10485 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HKX69_RS10590 ENOG4105CHU acetyl-coa acetyltransferase HKX69_RS10610 ENOG4105CJ1 ABC, transporter HKX69_RS10645 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) HKX69_RS10660 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HKX69_RS10690 ENOG4105BZU Histidine kinase HKX69_RS10695 ENOG4105WH1 Two component transcriptional regulator luxr family HKX69_RS10710 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HKX69_RS10715 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HKX69_RS10720 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HKX69_RS10725 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HKX69_RS10730 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HKX69_RS10735 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) HKX69_RS10740 ENOG4105ZA1 atp synthase HKX69_RS10750 ENOG4105Z3P ATP synthase HKX69_RS10755 ENOG4105ESV Glycosyl transferase, family 4 HKX69_RS10760 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HKX69_RS10765 ENOG4107ZF2 Phosphatase HKX69_RS10775 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HKX69_RS10780 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HKX69_RS10785 ENOG4105VFB Binds the 23S rRNA (By similarity) HKX69_RS10800 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HKX69_RS10805 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HKX69_RS10810 ENOG4105D6E homoserine dehydrogenase HKX69_RS10815 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HKX69_RS10820 ENOG4105C75 arginyL-tRNA synthetase HKX69_RS10940 ENOG4105FDF Could be involved in DNA repair (By similarity) HKX69_RS10945 ENOG4105DQE DNA ligase HKX69_RS10965 ENOG4108FKE two-component system sensor kinase HKX69_RS10970 ENOG4107QHZ cell cycle protein HKX69_RS10975 ENOG4105CJN penicillin-binding protein HKX69_RS11055 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HKX69_RS11070 ENOG4108PYU two-component system response regulator HKX69_RS11075 ENOG4105EB3 Histidine kinase HKX69_RS11080 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HKX69_RS11105 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HKX69_RS11145 ENOG4105CB2 alcohol dehydrogenase HKX69_RS11150 ENOG4105C6K Malic enzyme HKX69_RS11165 ENOG4105CDA abc transporter atp-binding protein HKX69_RS11170 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HKX69_RS11185 ENOG4108VEQ Superoxide dismutase HKX69_RS11215 ENOG4105ESN nucleotide-binding protein HKX69_RS11240 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HKX69_RS11255 ENOG4105CBD Diacylglycerol kinase HKX69_RS11275 ENOG4105CHR reductase HKX69_RS11280 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HKX69_RS11285 ENOG4105FDP GntR family transcriptional regulator HKX69_RS11310 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HKX69_RS11315 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HKX69_RS11330 ENOG41068W2 Cytochrome p-450 HKX69_RS11340 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HKX69_RS11355 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HKX69_RS11360 ENOG4105WMN AntiSigma factor HKX69_RS11365 ENOG4105EMN RNA polymerase sigma factor HKX69_RS11375 ENOG4108RAV Conserved protein HKX69_RS11385 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HKX69_RS11395 ENOG4105KPY Small multidrug resistance protein HKX69_RS11405 ENOG4107TK4 histidinol-phosphate phosphatase HKX69_RS11440 ENOG4105DJZ UPF0182 protein HKX69_RS11450 ENOG41063PX domain protein HKX69_RS11520 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HKX69_RS11540 ENOG4105E09 nadh pyrophosphatase HKX69_RS11545 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HKX69_RS11575 ENOG4106JDR secreted HKX69_RS11615 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HKX69_RS11620 ENOG4105DEF Extracellular solute-binding protein, family 5 HKX69_RS11660 ENOG4105C1J atp-dependent rna helicase HKX69_RS11680 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HKX69_RS11695 ENOG4105DXB Major Facilitator superfamily HKX69_RS11705 ENOG4105D7N magnesium and cobalt transport protein CorA HKX69_RS11750 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HKX69_RS11755 ENOG4105C0H protease HKX69_RS11765 ENOG4105DU6 RNA polymerase HKX69_RS11780 ENOG4105CGU Enoyl-CoA hydratase HKX69_RS11785 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HKX69_RS11795 ENOG4105EEI dihydropteroate synthase HKX69_RS11800 ENOG4108URH decarboxylase HKX69_RS11805 ENOG4107R4C succinyl-diaminopimelate desuccinylase HKX69_RS11825 ENOG4108Z4U Ferredoxin HKX69_RS11840 ENOG4108S01 response regulator HKX69_RS11845 ENOG4105BZU Histidine kinase HKX69_RS11855 ENOG4108M15 ABC transporter HKX69_RS11885 ENOG4108JQ7 (ABC) transporter HKX69_RS11890 ENOG4105C3U ABC transporter HKX69_RS11895 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HKX69_RS11900 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HKX69_RS11910 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HKX69_RS11915 ENOG4105DEF Extracellular solute-binding protein, family 5 HKX69_RS11930 ENOG4108JQ7 (ABC) transporter HKX69_RS11940 ENOG4108JQ7 (ABC) transporter HKX69_RS11955 ENOG4108J59 Extracellular solute-binding protein, family 5 HKX69_RS11960 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HKX69_RS11965 ENOG4105CI3 gtp-binding protein typa HKX69_RS11985 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HKX69_RS11990 ENOG4105E33 succinate dehydrogenase HKX69_RS12065 ENOG4105C3G gtp-binding protein HKX69_RS12080 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HKX69_RS12090 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HKX69_RS12095 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HKX69_RS12100 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HKX69_RS12125 ENOG4107GFK fumarate HKX69_RS12140 ENOG4105C9Q fumarate hydratase class II HKX69_RS12155 ENOG4105BZ4 penicillin-binding protein HKX69_RS12175 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HKX69_RS12190 ENOG4105D3R alkyl hydroperoxide reductase HKX69_RS12195 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HKX69_RS12205 ENOG4106770 Is able to cleave peptidoglycan (By similarity) HKX69_RS12210 ENOG4108IAB Phoh family HKX69_RS12215 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HKX69_RS12220 ENOG4105F2W methyltransferase HKX69_RS12260 ENOG4105RAK Histidine kinase HKX69_RS12290 ENOG4107QMS site-determining protein HKX69_RS12340 ENOG4105C6Z Gluconate HKX69_RS12345 ENOG4105KME endoribonuclease L-psp HKX69_RS12350 ENOG4108FUF Transcriptional regulator, IclR family HKX69_RS12380 ENOG4105CHM Aminotransferase HKX69_RS12410 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) HKX69_RS12435 ENOG4105C7Z Conserved Protein HKX69_RS12450 ENOG4105T1M mycothiol conjugate amidase mca HKX69_RS12460 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HKX69_RS12475 ENOG4105C7B Threonine dehydratase HKX69_RS12480 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HKX69_RS12485 ENOG4105NAF rna polymerase sigma factor HKX69_RS12505 ENOG4105D0M Protease HtpX homolog HKX69_RS12515 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HKX69_RS12535 ENOG4105DQ4 alcohol dehydrogenase HKX69_RS12550 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HKX69_RS12580 ENOG4105C84 Histidine ammonia-lyase HKX69_RS12585 ENOG4105KDM Diguanylate cyclase with gaf sensor HKX69_RS12590 ENOG4105E39 Enoyl-CoA hydratase HKX69_RS12600 ENOG4108QER Adenylate cyclase HKX69_RS12610 ENOG4105D8K carboxyl transferase HKX69_RS12620 ENOG4107WR6 Maf-like protein HKX69_RS12630 ENOG4108JIK carboxylase HKX69_RS12655 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain HKX69_RS12670 ENOG4105C26 Dehydrogenase HKX69_RS12675 ENOG4105C26 Dehydrogenase HKX69_RS12690 ENOG4105NAF rna polymerase sigma factor HKX69_RS12695 ENOG4108KXV response regulator HKX69_RS12700 ENOG41065SU Two-component system sensor kinase HKX69_RS12725 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HKX69_RS12735 ENOG4107RSM transcriptional regulator HKX69_RS12740 ENOG4105D94 Major Facilitator Superfamily HKX69_RS12775 ENOG4105UIB (ABC) transporter HKX69_RS12780 ENOG4108JQ9 ABC transporter HKX69_RS12785 ENOG4105DIH basic membrane HKX69_RS12790 ENOG4107RM1 amidohydrolase HKX69_RS12825 ENOG4105D2T synthase HKX69_RS12830 ENOG4105F0R Cytidylyltransferase HKX69_RS12840 ENOG4105K64 Glycosyl transferase, family 2 HKX69_RS12855 ENOG4105K64 Glycosyl transferase, family 2 HKX69_RS12865 ENOG4108NIW Leucine export protein LeuE HKX69_RS12870 ENOG4105D5P Methylmalonyl-coA mutase HKX69_RS12885 ENOG4108MMM RNA Polymerase HKX69_RS12915 ENOG4105E2D ec 3.2.1.52 HKX69_RS12935 ENOG4108J01 L-aspartate oxidase HKX69_RS12955 ENOG4105U5Y Transcriptional regulator HKX69_RS12970 ENOG4107RN3 metallophosphoesterase HKX69_RS12985 ENOG4107H3J ribonuclease HKX69_RS13000 ENOG4105C31 Tryptophanyl-tRNA synthetase HKX69_RS13005 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HKX69_RS13010 ENOG4105C8Y Acetylornithine aminotransferase HKX69_RS13025 ENOG4106032 Glutathionylspermidine synthase HKX69_RS13040 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HKX69_RS13045 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HKX69_RS13060 ENOG4108HQS Glycine betaine HKX69_RS13065 ENOG4108IJ7 Glycine betaine HKX69_RS13085 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HKX69_RS13095 ENOG4105WH1 Two component transcriptional regulator luxr family HKX69_RS13100 ENOG4105BZU Histidine kinase HKX69_RS13110 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HKX69_RS13145 ENOG4105CHR reductase HKX69_RS13155 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HKX69_RS13175 ENOG4105WQT MbtH domain protein HKX69_RS13180 ENOG4105CEY Amp-dependent synthetase and ligase HKX69_RS13195 ENOG4105CEY Amp-dependent synthetase and ligase HKX69_RS13235 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) HKX69_RS13250 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HKX69_RS13255 ENOG4105DC1 bifunctional purine biosynthesis protein purh HKX69_RS13285 ENOG4105CMV Succinyl-CoA synthetase subunit beta HKX69_RS13290 ENOG4105DEG Vwa containing coxe family protein HKX69_RS13300 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HKX69_RS13325 ENOG4105DR5 peptidase HKX69_RS13350 ENOG4105WH1 Two component transcriptional regulator luxr family HKX69_RS13390 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HKX69_RS13405 ENOG4105C26 Dehydrogenase HKX69_RS13410 ENOG4108UGD Serine Threonine protein kinase HKX69_RS13415 ENOG4105D9P serine threonine protein kinase HKX69_RS13420 ENOG4107TPY serine threonine protein kinase HKX69_RS13425 ENOG4105D9P serine threonine protein kinase HKX69_RS13435 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HKX69_RS13440 ENOG4107QQG Dehydrogenase HKX69_RS13445 ENOG4107QVP Dehydrogenase HKX69_RS13455 ENOG4108MMM RNA Polymerase HKX69_RS13465 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HKX69_RS13470 ENOG4105DND Transcriptional regulator HKX69_RS13480 ENOG4105EMU Dehydrogenase HKX69_RS13500 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HKX69_RS13525 ENOG4105CHP RNA polymerase HKX69_RS13540 ENOG4105ETE Transcriptional regulator (LacI family HKX69_RS13550 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HKX69_RS13575 ENOG4108097 ATP-binding protein HKX69_RS13580 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HKX69_RS13585 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HKX69_RS13600 ENOG4105CHR reductase HKX69_RS13605 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HKX69_RS13610 ENOG4105CS9 pantothenic acid kinase HKX69_RS13620 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HKX69_RS13625 ENOG4108UJD 30S ribosomal protein S9 HKX69_RS13630 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HKX69_RS13645 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HKX69_RS13650 ENOG4108ZT0 50S ribosomal protein l17 HKX69_RS13655 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HKX69_RS13660 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HKX69_RS13665 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HKX69_RS13670 ENOG41067V7 50S ribosomal protein L36 HKX69_RS13675 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HKX69_RS13685 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HKX69_RS13695 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HKX69_RS13700 ENOG410849U 50S ribosomal protein L30 HKX69_RS13705 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HKX69_RS13710 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HKX69_RS13715 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HKX69_RS13720 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HKX69_RS13725 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HKX69_RS13730 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HKX69_RS13735 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HKX69_RS13740 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HKX69_RS13745 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HKX69_RS13750 ENOG41082SA 50s ribosomal protein l29 HKX69_RS13755 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HKX69_RS13760 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HKX69_RS13765 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HKX69_RS13770 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HKX69_RS13775 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HKX69_RS13780 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HKX69_RS13785 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HKX69_RS13790 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HKX69_RS13795 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HKX69_RS13815 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HKX69_RS13820 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HKX69_RS13825 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HKX69_RS13830 ENOG4105VP2 Transcriptional regulator, Crp Fnr family HKX69_RS13860 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HKX69_RS13865 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HKX69_RS13885 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HKX69_RS13895 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HKX69_RS13915 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HKX69_RS13930 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HKX69_RS13935 ENOG4107R4N Cell wall formation (By similarity) HKX69_RS13955 ENOG410900P UPF0336 protein HKX69_RS13960 ENOG4105WDJ 50S ribosomal protein L33 HKX69_RS14005 ENOG4108VPT UPF0234 protein HKX69_RS14025 ENOG4105D0M Protease HtpX homolog HKX69_RS14030 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HKX69_RS14040 ENOG4105D65 subunit l HKX69_RS14045 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HKX69_RS14050 ENOG4107YX3 NADH dehydrogenase subunit j HKX69_RS14055 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HKX69_RS14060 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HKX69_RS14065 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HKX69_RS14070 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HKX69_RS14075 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HKX69_RS14095 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HKX69_RS14100 ENOG4105DQU oxidoreductase, subunit beta HKX69_RS14105 ENOG4105KVH Transcriptional regulator HKX69_RS14110 ENOG4105ECR NmrA family HKX69_RS14140 ENOG4105CJ1 ABC, transporter HKX69_RS14155 ENOG4108FKH Transglycosylase SLT domain HKX69_RS14160 ENOG410667J hydrolase HKX69_RS14175 ENOG4105C9U ATP-dependent DNA helicase RecQ HKX69_RS14185 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HKX69_RS14195 ENOG4105D65 subunit l HKX69_RS14200 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HKX69_RS14205 ENOG4105DF2 NADH dehydrogenase subunit j HKX69_RS14210 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HKX69_RS14215 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HKX69_RS14220 ENOG4108IEH NADH dehydrogenase subunit g HKX69_RS14225 ENOG4107QIZ NADH dehydrogenase HKX69_RS14235 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HKX69_RS14240 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HKX69_RS14245 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HKX69_RS14260 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HKX69_RS14270 ENOG4105KNA -acetyltransferase HKX69_RS14280 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HKX69_RS14290 ENOG4107QJZ Glycosyl transferase, family 2 HKX69_RS14300 ENOG4108NNZ chitinase HKX69_RS14310 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HKX69_RS14320 ENOG4105EV6 Pfam:DUF178 HKX69_RS14325 ENOG4105VEQ Cold shock protein HKX69_RS14345 ENOG4108762 serine threonine protein kinase HKX69_RS14350 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HKX69_RS14385 ENOG4108R86 Transcriptional regulator HKX69_RS14405 ENOG4105DVY radical SAM domain protein HKX69_RS14410 ENOG4105EW9 transcriptional regulator AsnC family HKX69_RS14415 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HKX69_RS14425 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HKX69_RS14445 ENOG4105CRE cytochrome C HKX69_RS14450 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) HKX69_RS14455 ENOG4107QIV Cytochrome c biogenesis protein HKX69_RS14470 ENOG4108RH7 phosphoglycerate mutase HKX69_RS14475 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HKX69_RS14505 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HKX69_RS14520 ENOG4107S9R deoxycytidine triphosphate deaminase HKX69_RS14525 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HKX69_RS14530 ENOG4107S1E Beta-lactamase HKX69_RS14580 ENOG4108ME1 Peptidase M55 D-aminopeptidase HKX69_RS14595 ENOG41062D9 Histidine kinase HKX69_RS14605 ENOG4108UZX fmn reductase HKX69_RS14610 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HKX69_RS14615 ENOG4105KK4 UPF0060 membrane protein HKX69_RS14640 ENOG4105E0Y RtcB Protein HKX69_RS14660 ENOG4105DK7 lysyl-tRNA synthetase HKX69_RS14665 ENOG4105C75 arginyL-tRNA synthetase HKX69_RS14695 ENOG4105D52 delta-aminolevulinic acid dehydratase HKX69_RS14705 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HKX69_RS14710 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HKX69_RS14715 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HKX69_RS14720 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HKX69_RS14765 ENOG4108XFF HKX69_RS14770 ENOG4105DGU Histone deacetylase HKX69_RS14775 ENOG4106UW1 Major Facilitator superfamily HKX69_RS14785 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HKX69_RS14805 ENOG4105C31 Tryptophanyl-tRNA synthetase HKX69_RS14810 ENOG4105II7 pyrroline-5-carboxylate reductase HKX69_RS14820 ENOG4105CJ1 ABC, transporter HKX69_RS14835 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein HKX69_RS14840 ENOG4108762 serine threonine protein kinase HKX69_RS14845 ENOG4105C01 Dihydroxy-acid dehydratase HKX69_RS14855 ENOG4105EY0 Xylose isomerase domain protein TIM barrel HKX69_RS14860 ENOG4107R33 ppx gppa phosphatase HKX69_RS14865 ENOG4108JWX HKX69_RS14880 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HKX69_RS14895 ENOG4105NAF rna polymerase sigma factor HKX69_RS14900 ENOG41075QH Lipoprotein CseA HKX69_RS14905 ENOG4108PYU two-component system response regulator HKX69_RS14910 ENOG4108FKE two-component system sensor kinase HKX69_RS14930 ENOG4108IG5 Transcriptional regulator HKX69_RS14935 ENOG4105DR5 peptidase HKX69_RS14980 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HKX69_RS14990 ENOG4108IYU L-aspartate oxidase HKX69_RS14995 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HKX69_RS15020 ENOG4105WH1 Two component transcriptional regulator luxr family HKX69_RS15035 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HKX69_RS15060 ENOG4105CRK lysyL-tRNA synthetase HKX69_RS15080 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HKX69_RS15090 ENOG4105EUJ GTP cyclohydrolase i HKX69_RS15100 ENOG4108UGV hypoxanthine phosphoribosyltransferase HKX69_RS15105 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HKX69_RS15120 ENOG4105F0N pyrophosphate phospho-hydrolase HKX69_RS15135 ENOG4107TXC Transcriptional regulator HKX69_RS15140 ENOG4105VCT ion-transport protein YfeO HKX69_RS15145 ENOG4105CVK Glutamate decarboxylase HKX69_RS15170 ENOG4105C26 Dehydrogenase HKX69_RS15225 ENOG4105C2M dna polymerase I HKX69_RS15260 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HKX69_RS15265 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HKX69_RS15285 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for HKX69_RS15290 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HKX69_RS15295 ENOG4105WN5 stage II sporulation protein HKX69_RS15300 ENOG4108I5C dEAD DEAH box helicase HKX69_RS15360 ENOG4107B2H carbonic anhydrase HKX69_RS15365 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HKX69_RS15380 ENOG4105D74 hydrolase HKX69_RS15390 ENOG4105P8F nudix hydrolase HKX69_RS15410 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HKX69_RS15445 ENOG4105BZ4 penicillin-binding protein HKX69_RS15450 ENOG4105KTH gatB Yqey HKX69_RS15475 ENOG4105ETE Transcriptional regulator (LacI family HKX69_RS15570 ENOG4105C31 Tryptophanyl-tRNA synthetase HKX69_RS15575 ENOG4105CIH Imidazole acetol-phosphate transaminase HKX69_RS15600 ENOG4105M6F mutator MutT protein HKX69_RS15625 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HKX69_RS15630 ENOG4105DZR Type I site-specific deoxyribonuclease HKX69_RS15640 ENOG4105CVR type I restriction-modification system HKX69_RS15680 ENOG4108KQ5 Integrase catalytic subunit HKX69_RS15715 ENOG41082YX Transcriptional regulator, arsr family HKX69_RS15755 ENOG4108PJD permease HKX69_RS15795 ENOG4105CFH Aspartokinase HKX69_RS15805 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HKX69_RS15810 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HKX69_RS15825 ENOG4108JPW Aminotransferase HKX69_RS15830 ENOG4108WYP Transcriptional regulator HKX69_RS15865 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HKX69_RS15880 ENOG4105WH1 Two component transcriptional regulator luxr family HKX69_RS15885 ENOG4105BZU Histidine kinase HKX69_RS15895 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HKX69_RS15900 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) HKX69_RS15925 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HKX69_RS15940 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HKX69_RS15970 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HKX69_RS16000 ENOG4105DFW ABC transporter HKX69_RS16005 ENOG4105KNI merR family transcriptional Regulator HKX69_RS16010 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HKX69_RS16015 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HKX69_RS16020 ENOG4105CFG Acts as a chaperone (By similarity) HKX69_RS16030 ENOG4105DF6 Fe-S oxidoreductase HKX69_RS16060 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HKX69_RS16065 ENOG4105DHP deoxycytidine triphosphate deaminase HKX69_RS16075 ENOG4108KQ5 Integrase catalytic subunit HKX69_RS16090 ENOG4106CY5 excisionase HKX69_RS16120 ENOG4108KQ5 Integrase catalytic subunit HKX69_RS16240 ENOG4105VEQ Cold shock protein HKX69_RS16255 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth HKX69_RS16340 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HKX69_RS16350 ENOG4105CUB amino acid HKX69_RS16355 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) HKX69_RS16360 ENOG4105KPV Transcriptional regulator HKX69_RS16370 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HKX69_RS16380 ENOG41080XP Cbs domain HKX69_RS16390 ENOG4105VEQ Cold shock protein HKX69_RS16395 ENOG4105C1J atp-dependent rna helicase HKX69_RS16405 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase HKX69_RS16410 ENOG4108KPJ rna polymerase sigma factor HKX69_RS16420 ENOG4105BZ9 Cytochrome C oxidase, subunit I HKX69_RS16440 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HKX69_RS16460 ENOG4105CG3 alpha amylase, catalytic region HKX69_RS16465 ENOG41066UM arsR family transcriptional regulator HKX69_RS16470 ENOG4105D9G High-affinity HKX69_RS16475 ENOG4105DU0 nucleoside hydrolase HKX69_RS16530 ENOG4105EM2 membrane HKX69_RS16540 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HKX69_RS16565 ENOG4105C9M aspartyl-trna synthetase HKX69_RS16580 ENOG4105EUB pirin domain protein HKX69_RS16590 ENOG4105CSU acyl-Coa dehydrogenase HKX69_RS16595 ENOG4105DFM M18 family aminopeptidase HKX69_RS16645 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 HKX69_RS16650 ENOG4105CPP Dehydrogenase, E1 component HKX69_RS16670 ENOG4107QPV Serine Threonine protein kinase HKX69_RS16675 ENOG4108VC7 Protein of unknown function (DUF2587) HKX69_RS16690 ENOG4107SVH Potassium channel protein HKX69_RS16705 ENOG4107QSN dihydrolipoamide acetyltransferase HKX69_RS16730 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HKX69_RS16755 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HKX69_RS16760 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HKX69_RS16765 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HKX69_RS16770 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HKX69_RS16775 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HKX69_RS16795 ENOG4107SCK Monooxygenase HKX69_RS16810 ENOG4105C0W non-ribosomal peptide synthetase HKX69_RS16830 ENOG4105E8R UPF0173 metal-dependent hydrolase HKX69_RS16850 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HKX69_RS16860 ENOG4105CHR reductase HKX69_RS16865 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HKX69_RS16870 ENOG4105CHR reductase HKX69_RS16885 ENOG4105CPC Aldo Keto reductase HKX69_RS16910 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HKX69_RS16930 ENOG4105CPC Aldo Keto reductase HKX69_RS16940 ENOG4105TV9 FHA Domain-Containing protein HKX69_RS16945 ENOG4105HZM Fha domain containing protein HKX69_RS16960 ENOG4105CJN penicillin-binding protein HKX69_RS16970 ENOG4108RN7 integral membrane protein HKX69_RS16975 ENOG4108U4N (sortase) family HKX69_RS16995 ENOG4105ZJT Cell division protein CrgA HKX69_RS17025 ENOG4108UGD Serine Threonine protein kinase HKX69_RS17055 ENOG4108HMN Caspase domain HKX69_RS17055 ENOG4108HMN Caspase domain HKX69_RS17070 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HKX69_RS17075 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HKX69_RS17080 ENOG4105K7N UPF0232 protein HKX69_RS17085 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HKX69_RS17090 ENOG4108J5G 6-phosphogluconate dehydrogenase HKX69_RS17095 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HKX69_RS17100 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HKX69_RS17105 ENOG41084CH 50S ribosomal protein l34 HKX69_RS17110 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HKX69_RS17115 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HKX69_RS17120 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HKX69_RS17130 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HKX69_RS17135 ENOG4107QJE Chromosome Partitioning Protein HKX69_RS17150 ENOG4105K63 Thioredoxin HKX69_RS17155 ENOG4105C3M thioredoxin reductase HKX69_RS17170 ENOG4105D9P serine threonine protein kinase HKX69_RS17185 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HKX69_RS17205 ENOG4108JQC penicillin-binding protein 1A HKX69_RS17230 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) HKX69_RS17235 ENOG4107YH6 single-stranded DNA-binding protein HKX69_RS17240 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HKX69_RS17245 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HKX69_RS17255 ENOG4105CDU Replicative dna helicase HKX69_RS17275 ENOG4105F27 Major Facilitator HKX69_RS17300 ENOG4105C28 cystathionine HKX69_RS17305 ENOG4105KJF protein tyrosine phosphatase HKX69_RS17310 ENOG41082T9 Membrane HKX69_RS17315 ENOG4106048 Cupin 2, conserved barrel domain protein HKX69_RS17340 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HKX69_RS17350 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HKX69_RS17355 ENOG4107P2S Transcriptional regulator HKX69_RS17360 ENOG4105CIH Imidazole acetol-phosphate transaminase HKX69_RS17365 ENOG4105C4M (Ubiquinol oxidase) subunit I HKX69_RS17370 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HKX69_RS17375 ENOG4108JJ9 ABC, transporter HKX69_RS17380 ENOG4108K4B hydrolase HKX69_RS17390 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) HKX69_RS17430 ENOG410667J hydrolase HKX69_RS17435 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HKX69_RS17440 ENOG4105CQC Prephenate dehydratase HKX69_RS17445 ENOG4105DBE peroxidase HKX69_RS17480 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HKX69_RS17485 ENOG4107T6F Xaa-Pro aminopeptidase HKX69_RS17505 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HKX69_RS17520 ENOG4105C0H protease HKX69_RS17540 ENOG4105NAF rna polymerase sigma factor HKX69_RS17545 ENOG4105CEY Amp-dependent synthetase and ligase HKX69_RS17550 ENOG4108UXN response regulator HKX69_RS17625 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HKX69_RS17630 ENOG4105BZU Histidine kinase HKX69_RS17640 ENOG4105EDW glycosyl transferase, family 39 HKX69_RS17645 ENOG4105C57 major facilitator superfamily HKX69_RS17660 ENOG410905P Pyridoxamine 5-phosphate HKX69_RS17665 ENOG4108YYC ycei family HKX69_RS17670 ENOG4105C0R drug resistance transporter emrb qaca subfamily HKX69_RS17675 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HKX69_RS17685 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HKX69_RS17690 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HKX69_RS17695 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein HKX69_RS17710 ENOG4108Z6B deaminase HKX69_RS17725 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HKX69_RS17740 ENOG4105D7A ATP-binding protein HKX69_RS17775 ENOG4108T5E Copper resistance protein HKX69_RS17790 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HKX69_RS17820 ENOG4105C12 Phosphoribosylglycinamide synthetase HKX69_RS17835 ENOG4105C8V SAICAR synthetase HKX69_RS17880 ENOG410839H phosphoribosylformylglycinamidine synthase HKX69_RS17885 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HKX69_RS17890 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HKX69_RS17915 ENOG4105CXB phosphoribosylaminoimidazole synthetase HKX69_RS17930 ENOG4108TAC HKX69_RS17950 ENOG4105CQ7 ATP-dependent helicase HKX69_RS17995 ENOG4105C1J atp-dependent rna helicase HKX69_RS18020 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HKX69_RS18050 ENOG4105CPC Aldo Keto reductase HKX69_RS18060 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HKX69_RS18065 ENOG4105D5U fad dependent oxidoreductase HKX69_RS18170 ENOG4105K4H Nlp p60 protein HKX69_RS18175 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HKX69_RS18180 ENOG4105DNP FAD linked oxidase domain protein HKX69_RS18200 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HKX69_RS18205 ENOG4105CJ3 phosphate transporter HKX69_RS18215 ENOG4105VPX protein, conserved in bacteria HKX69_RS18245 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HKX69_RS18255 ENOG4105DA5 (ABC) transporter HKX69_RS18260 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HKX69_RS18265 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HKX69_RS18270 ENOG4105CGH 5'-nucleotidase HKX69_RS18290 ENOG4105ETX regulatoR HKX69_RS18305 ENOG4105ETE Transcriptional regulator (LacI family HKX69_RS18310 ENOG4107NHD transcriptional regulator HKX69_RS18330 ENOG4105FQP Beta-lactamase HKX69_RS18335 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HKX69_RS18340 ENOG41090R7 Ferric uptake HKX69_RS18350 ENOG4105CVR type I restriction-modification system HKX69_RS18360 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands HKX69_RS18380 ENOG4105KHC sulfurtransferase HKX69_RS18385 ENOG4105PKJ carbohydrate binding HKX69_RS18410 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HKX69_RS18420 ENOG4105FDP GntR family transcriptional regulator HKX69_RS18430 ENOG4107YCY Transcriptional regulator HKX69_RS18435 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HKX69_RS18450 ENOG4105YIP Tetr family transcriptional regulator HKX69_RS18455 ENOG4105EEM helicase HKX69_RS18465 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HKX69_RS18500 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HKX69_RS18505 ENOG4108YZJ Pfam:DUF2596 HKX69_RS18545 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HKX69_RS18570 ENOG4105BZU Histidine kinase HKX69_RS18585 ENOG4108VJ1 Transcriptional regulator (CarD family HKX69_RS18590 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HKX69_RS18595 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HKX69_RS18605 ENOG4105C8N cysteinyl-tRNA synthetase HKX69_RS18610 ENOG4105C2N RNA methyltransferase TrmH family group 3 HKX69_RS18615 ENOG4108KQ5 Integrase catalytic subunit HKX69_RS18625 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HKX69_RS18695 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HKX69_RS18715 ENOG4105BZU Histidine kinase HKX69_RS18725 ENOG4105DE4 1-phosphofructokinase HKX69_RS18730 ENOG4105CE4 GlcNAc 6-P deacetylase HKX69_RS18735 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) HKX69_RS18740 ENOG4105XN3 extracellular solute-binding protein family 1 HKX69_RS18760 ENOG4105C3Q Glycosyl transferase, family 2 HKX69_RS18775 ENOG4105VEQ Cold shock protein HKX69_RS18780 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HKX69_RS18795 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HKX69_RS18800 ENOG4105QEK Transcriptional regulator HKX69_RS18830 ENOG4106N3A copper homeostasis protein cutc HKX69_RS18835 ENOG4105EEM helicase HKX69_RS18860 ENOG4105CFI type iii restriction protein res subunit HKX69_RS18895 ENOG4105VEQ Cold shock protein HKX69_RS18900 ENOG4105E63 Pfam:DUF178 HKX69_RS18905 ENOG4108UIH futalosine nucleosidase HKX69_RS18915 ENOG4108N0W Major Facilitator superfamily HKX69_RS18945 ENOG4105CSR polyphosphate kinase 2 HKX69_RS18975 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HKX69_RS18985 ENOG4105C7N Xanthine uracil vitamin C permease HKX69_RS18995 ENOG4105XMC MarR family Transcriptional regulator HKX69_RS19015 ENOG4105CPC Aldo Keto reductase HKX69_RS19035 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HKX69_RS19060 ENOG4107AQZ Membrane HKX69_RS19080 ENOG4107QX3 carboxylase HKX69_RS19095 ENOG4105CEY Amp-dependent synthetase and ligase HKX69_RS19105 ENOG4108IG5 Transcriptional regulator HKX69_RS19120 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HKX69_RS19135 ENOG4108SU4 UPF0309 protein HKX69_RS19145 ENOG4108XEP Alpha Beta Hydrolase Fold protein HKX69_RS19190 ENOG4105WN5 stage II sporulation protein HKX69_RS19195 ENOG4107EG8 signal transduction protein with EFhand domain HKX69_RS19215 ENOG4105D2S major facilitator superfamily HKX69_RS19220 ENOG4105H3G oxidoreductase HKX69_RS19225 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HKX69_RS19230 ENOG4105N14 lysine exporter protein LysE YggA HKX69_RS19235 ENOG4108ZRZ Transcriptional regulator (AsnC family) HKX69_RS19240 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HKX69_RS19250 ENOG4108762 serine threonine protein kinase HKX69_RS19320 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HKX69_RS19370 ENOG4108V06 Glutathione peroxidase HKX69_RS19415 ENOG4107HP6 Transcriptional regulator HKX69_RS19440 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HKX69_RS19445 ENOG4108Z7F N-acetyltransferase HKX69_RS19470 ENOG410804X Transcriptional regulator HKX69_RS19475 ENOG4105DE4 1-phosphofructokinase HKX69_RS19480 ENOG4105DM4 PTS System HKX69_RS19500 ENOG4105KXX peptidase s58 dmpa HKX69_RS19515 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HKX69_RS19525 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) HKX69_RS19535 ENOG4105C0R drug resistance transporter emrb qaca subfamily HKX69_RS19540 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) HKX69_RS19550 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase HKX69_RS19555 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HKX69_RS19565 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HKX69_RS19570 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HKX69_RS19575 ENOG4105D9U N-acetyltransferase HKX69_RS19595 ENOG4105CGK Exodeoxyribonuclease III HKX69_RS19600 ENOG4107SWG transcriptional regulator MERR family HKX69_RS19605 ENOG4105F95 Monooxygenase HKX69_RS19610 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HKX69_RS19615 ENOG4108R85 Short chain dehydrogenase HKX69_RS19635 ENOG4105EYF MMPL domain protein HKX69_RS19640 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HKX69_RS19660 ENOG4108JJB ABC transporter HKX69_RS19670 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HKX69_RS19705 ENOG4105F8V Hydrolase, tatD family HKX69_RS19710 ENOG41069ER domain protein HKX69_RS19715 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HKX69_RS19720 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HKX69_RS19730 ENOG4105C5H ABC transporter HKX69_RS19770 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HKX69_RS19785 ENOG4105WH1 Two component transcriptional regulator luxr family HKX69_RS19790 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HKX69_RS19795 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HKX69_RS19800 ENOG41067SE Tetr family transcriptional regulator HKX69_RS19810 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HKX69_RS19820 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HKX69_RS19825 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HKX69_RS19830 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HKX69_RS19835 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HKX69_RS19880 ENOG4107QN1 sodium solute HKX69_RS19890 ENOG4105C0R drug resistance transporter emrb qaca subfamily HKX69_RS19895 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HKX69_RS19900 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HKX69_RS19975 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HKX69_RS20005 ENOG4105CEP NADH dehydrogenase HKX69_RS20010 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HKX69_RS20015 ENOG4107RBB ABC transporter, permease HKX69_RS20020 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HKX69_RS20030 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) HKX69_RS20120 ENOG4105CHU acetyl-coa acetyltransferase HKX69_RS20140 ENOG4105EMU Dehydrogenase HKX69_RS20185 ENOG4105CGP Urocanate hydratase HKX69_RS20200 ENOG4105CI2 imidazolone-5-propionate hydrolase HKX69_RS20220 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HKX69_RS20225 ENOG41082AN stage II sporulation protein HKX69_RS20240 ENOG4105DUX Transporter HKX69_RS20245 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HKX69_RS20250 ENOG41065SU Two-component system sensor kinase HKX69_RS20265 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HKX69_RS20290 ENOG4105C6Y Udp-glucose 6-dehydrogenase HKX69_RS20305 ENOG4108KGH TRANSCRIPTIONal HKX69_RS20325 ENOG4105F9F transposase HKX69_RS20330 ENOG4108KGH TRANSCRIPTIONal HKX69_RS20340 ENOG4108KGH TRANSCRIPTIONal HKX69_RS20355 ENOG4107V9E glucose-1-phosphate thymidylyltransferase HKX69_RS20365 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) HKX69_RS20380 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HKX69_RS20385 ENOG4107RGC Glycosyl transferase, family 2 HKX69_RS20410 ENOG4105W49 UPF0434 protein HKX69_RS20420 ENOG4105EIP mannose-6-phosphate isomerase HKX69_RS20430 ENOG4107QYR Signal peptidase i HKX69_RS20435 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HKX69_RS20475 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HKX69_RS20480 ENOG4108WQ6 secreted protein HKX69_RS20495 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HKX69_RS20500 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HKX69_RS20505 ENOG4105BZU Histidine kinase HKX69_RS20510 ENOG4105G3P Lipoprotein lpqB HKX69_RS20520 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea HKX69_RS20525 ENOG4105WH1 Two component transcriptional regulator luxr family HKX69_RS20530 ENOG4105T0Z Conserved Protein HKX69_RS20540 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HKX69_RS20565 ENOG4105C7I Dehydrogenase HKX69_RS20580 ENOG4107SJB teichoic acid biosynthesis HKX69_RS20585 ENOG4105EY8 ABC transporter HKX69_RS20615 ENOG4105K56 Transcriptional regulator HKX69_RS20620 ENOG4108ZHJ Organic hydroperoxide resistance protein HKX69_RS20625 ENOG4107SJB teichoic acid biosynthesis HKX69_RS20630 ENOG4107SJB teichoic acid biosynthesis HKX69_RS20635 ENOG4107SJB teichoic acid biosynthesis HKX69_RS20640 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HKX69_RS20660 ENOG4108UGD Serine Threonine protein kinase HKX69_RS20665 ENOG4108QVN serine threonine protein kinase HKX69_RS20670 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HKX69_RS20685 ENOG4105CAK Cell division ATP-binding protein ftsE HKX69_RS20690 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) HKX69_RS20695 ENOG4105CN1 protease HKX69_RS20700 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HKX69_RS20715 ENOG4105F04 LysR family Transcriptional regulator HKX69_RS20755 ENOG4105DQQ Major facilitator superfamily MFS_1 HKX69_RS20775 ENOG4105EEM helicase HKX69_RS20785 ENOG4108426 dNA-binding protein HKX69_RS20790 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HKX69_RS20795 ENOG4108UJU UPF0301 protein HKX69_RS20805 ENOG4105E2D ec 3.2.1.52 HKX69_RS20820 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HKX69_RS20880 ENOG4107R4C succinyl-diaminopimelate desuccinylase HKX69_RS20895 ENOG4105DTQ mandelate racemase muconate lactonizing HKX69_RS20910 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HKX69_RS20920 ENOG4105CQB FAD linked oxidase domain protein HKX69_RS20925 ENOG4105KF0 sporulation and cell division protein, SsgA HKX69_RS20955 ENOG4108RWI nicotinamidase HKX69_RS20965 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HKX69_RS20975 ENOG4105C85 amino acid HKX69_RS21025 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HKX69_RS21040 ENOG4108IUW ABC transporter HKX69_RS21055 ENOG4105BZ4 penicillin-binding protein HKX69_RS21060 ENOG4105KPY Small multidrug resistance protein HKX69_RS21085 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HKX69_RS21095 ENOG4106BRA Membrane HKX69_RS21100 ENOG4105C54 Major Facilitator superfamily HKX69_RS21120 ENOG41087EV Hsp20/alpha crystallin family HKX69_RS21180 ENOG4108PJD permease HKX69_RS21220 ENOG41090KN UPF0303 protein HKX69_RS21225 ENOG4105D9R oxidoreductase HKX69_RS21230 ENOG4105E2R ROK family HKX69_RS21255 ENOG4105JXH GntR family transcriptional regulator HKX69_RS21275 ENOG4108M1A Chitin-binding protein HKX69_RS21315 ENOG4105C5I Dehydrogenase HKX69_RS21345 ENOG4105BZU Histidine kinase HKX69_RS21350 ENOG4105DEN Luciferase family HKX69_RS21375 ENOG4108ZM9 phosphoglycerate mutase HKX69_RS21400 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HKX69_RS21405 ENOG4105BZU Histidine kinase HKX69_RS21410 ENOG4108NNZ chitinase HKX69_RS21420 ENOG4105ETE Transcriptional regulator (LacI family HKX69_RS21435 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HKX69_RS21445 ENOG4105ETE Transcriptional regulator (LacI family HKX69_RS21455 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HKX69_RS21460 ENOG4105ECQ AraC Family Transcriptional Regulator HKX69_RS21480 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HKX69_RS21500 ENOG4105E2D ec 3.2.1.52 HKX69_RS21505 ENOG4105DUU IucA IucC family protein HKX69_RS21515 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HKX69_RS21535 ENOG4105C1G acyl-Coa dehydrogenase HKX69_RS21540 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HKX69_RS21550 ENOG4107QX3 carboxylase HKX69_RS21570 ENOG4105C29 acyl-CoA thioesterase HKX69_RS21580 ENOG4108XFF HKX69_RS21590 ENOG4105CK7 Sodium proline symporter HKX69_RS21600 ENOG4105C7K acetolactate synthase HKX69_RS21620 ENOG4105BZ1 (ABC) transporter HKX69_RS21645 ENOG4108KQ5 Integrase catalytic subunit HKX69_RS21650 ENOG4105D17 glycoside hydrolase, family 3 domain protein HKX69_RS21675 ENOG410645S MarR family Transcriptional regulator HKX69_RS21685 ENOG4105ETE Transcriptional regulator (LacI family HKX69_RS21705 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HKX69_RS21710 ENOG4108RVA ribokinase HKX69_RS21715 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HKX69_RS21720 ENOG4105C2J ABC transporter HKX69_RS21725 ENOG4105ETE Transcriptional regulator (LacI family HKX69_RS21745 ENOG4105C7H Helicase, RecD TraA family HKX69_RS21820 ENOG4105CPQ Dehydrogenase HKX69_RS21830 ENOG4105EDK PfkB domain protein HKX69_RS21840 ENOG4105DH8 myo-inositol catabolism HKX69_RS21845 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HKX69_RS21850 ENOG4105C26 Dehydrogenase HKX69_RS21865 ENOG4105CJ1 ABC, transporter HKX69_RS21915 ENOG4105JNK Glycosyl transferase (Group 1 HKX69_RS21935 ENOG4105D3Q Sugar transferase HKX69_RS21995 ENOG4105C5I Dehydrogenase HKX69_RS22010 ENOG4105ECR NmrA family HKX69_RS22160 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HKX69_RS22165 ENOG4105VHU single-stranded DNA-binding protein HKX69_RS22200 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HKX69_RS22220 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HKX69_RS22250 ENOG4105CT1 (ABC) transporter HKX69_RS22260 ENOG4105ETS cytosine purines uracil thiamine allantoin HKX69_RS22270 ENOG4105F8D glycoside hydrolase family 4 HKX69_RS22275 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HKX69_RS22280 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HKX69_RS22290 ENOG4105E2R ROK family HKX69_RS22310 ENOG4105D8X mechanosensitive ion channel HKX69_RS22330 ENOG4105CJ1 ABC, transporter HKX69_RS22370 ENOG4108ZT1 Transcriptional regulator HKX69_RS22375 ENOG4108KTG Membrane protein, drug metabolite transporter HKX69_RS22430 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HKX69_RS22440 ENOG4108UYE Lactoylglutathione lyase HKX69_RS22470 ENOG4108TCJ secreted hydrolase HKX69_RS22485 ENOG4105MC2 DSBA oxidoreductase HKX69_RS22490 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HKX69_RS22495 ENOG4105C85 amino acid HKX69_RS22510 ENOG4105E2Y ABC, transporter HKX69_RS22515 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HKX69_RS22525 ENOG4105E2R ROK family HKX69_RS22535 ENOG4105C85 amino acid HKX69_RS22565 ENOG4108TGC Acyltransferase HKX69_RS22585 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HKX69_RS22590 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HKX69_RS22595 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HKX69_RS22600 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HKX69_RS22610 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HKX69_RS22615 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HKX69_RS22625 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HKX69_RS22630 ENOG4105DFF Rod shape-determining protein mreb HKX69_RS22645 ENOG4105CJN penicillin-binding protein HKX69_RS22650 ENOG4105CNI cell division protein FtsW HKX69_RS22680 ENOG4105C03 ribonuclease HKX69_RS22690 ENOG4108MDK Dehydrogenase HKX69_RS22695 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HKX69_RS22700 ENOG4105K46 50S ribosomal protein l27 HKX69_RS22705 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HKX69_RS22715 ENOG4107SJB teichoic acid biosynthesis HKX69_RS22720 ENOG4105K64 Glycosyl transferase, family 2 HKX69_RS22735 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HKX69_RS22745 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HKX69_RS22760 ENOG4105D0M Protease HtpX homolog HKX69_RS22775 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HKX69_RS22790 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HKX69_RS22820 ENOG4108U8T Mannosyltransferase HKX69_RS22830 ENOG4107QIZ NADH dehydrogenase HKX69_RS22840 ENOG4105C8T Leucyl-tRNA synthetase HKX69_RS22850 ENOG4105EPR degv family HKX69_RS22855 ENOG4105KQC Competence protein HKX69_RS22890 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HKX69_RS22905 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HKX69_RS22910 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HKX69_RS22940 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HKX69_RS22945 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HKX69_RS22950 ENOG4105EA8 2-Nitropropane dioxygenase HKX69_RS22970 ENOG4107RE3 peptidase, S41 HKX69_RS22975 ENOG4107YU2 histidine triad (hIT) protein HKX69_RS22980 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HKX69_RS22995 ENOG4105EQX glucarate dehydratase HKX69_RS23000 ENOG4107UEK pfkb domain protein HKX69_RS23010 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HKX69_RS23020 ENOG4105MSB protein, conserved in bacteria HKX69_RS23040 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HKX69_RS23065 ENOG4105D4Y metalloprotease HKX69_RS23070 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HKX69_RS23085 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HKX69_RS23090 ENOG4108JQ7 (ABC) transporter HKX69_RS23095 ENOG4105C3U ABC transporter HKX69_RS23105 ENOG4105DEF Extracellular solute-binding protein, family 5 HKX69_RS23110 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HKX69_RS23115 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HKX69_RS23135 ENOG4105FDK ABC transporter HKX69_RS23145 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HKX69_RS23155 ENOG4108FN7 Aldo keto reductase HKX69_RS23215 ENOG4105E2R ROK family HKX69_RS23220 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HKX69_RS23225 ENOG4107FKK extracellular solute-binding protein family 1 HKX69_RS23230 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HKX69_RS23235 ENOG4105DRS transport system, permease HKX69_RS23240 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HKX69_RS23245 ENOG4105YA8 Transcriptional regulator HKX69_RS23250 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HKX69_RS23260 ENOG4107QZF nitrite reductase NADPH large subunit HKX69_RS23275 ENOG4105KVH Transcriptional regulator HKX69_RS23305 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HKX69_RS23310 ENOG4108UB4 uncharacterized protein ygjQ HKX69_RS23320 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HKX69_RS23330 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HKX69_RS23335 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HKX69_RS23375 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HKX69_RS23385 ENOG4105FDP GntR family transcriptional regulator HKX69_RS23450 ENOG4105D8K carboxyl transferase HKX69_RS23455 ENOG4105CEY Amp-dependent synthetase and ligase HKX69_RS23480 ENOG4105J4Q Transcriptional regulator HKX69_RS23485 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HKX69_RS23520 ENOG4105CIH Imidazole acetol-phosphate transaminase HKX69_RS23525 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HKX69_RS23530 ENOG4108HWW ABC transporter HKX69_RS23555 ENOG4105CXK mandelate racemase muconate lactonizing HKX69_RS23570 ENOG4108ZHJ Organic hydroperoxide resistance protein HKX69_RS23575 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HKX69_RS23590 ENOG4105NGS secreted protein HKX69_RS23595 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HKX69_RS23620 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HKX69_RS23625 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HKX69_RS23655 ENOG4105VUF Transcriptional regulator HKX69_RS23685 ENOG4105EYW Ion transport protein HKX69_RS23690 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HKX69_RS23735 ENOG4105DAX Pfam:DUF2983 HKX69_RS23750 ENOG4105BZ4 penicillin-binding protein HKX69_RS23820 ENOG4107VXZ Hydrolase HKX69_RS23865 ENOG4105CSH Transporter HKX69_RS23875 ENOG4105XPP Protein of unknown function (DUF1275) HKX69_RS23895 ENOG4108JJB ABC transporter HKX69_RS23950 ENOG4108SGK Tetr family transcriptional regulator HKX69_RS23955 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HKX69_RS23960 ENOG4107QVI Methyltransferase, type 11 HKX69_RS23985 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HKX69_RS24010 ENOG4108S01 response regulator HKX69_RS24025 ENOG4105BZU Histidine kinase HKX69_RS24045 ENOG4105EGD dinuclear metal center protein, YbgI family HKX69_RS24060 ENOG4108UHU Aldolase HKX69_RS24065 ENOG4107XFJ UPF0246 protein HKX69_RS24070 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HKX69_RS24075 ENOG4105E7U AraC family transcriptional regulator HKX69_RS24090 ENOG4108VGI doxx family HKX69_RS24095 ENOG4105CPC Aldo Keto reductase HKX69_RS24110 ENOG4105D9R oxidoreductase HKX69_RS24115 ENOG4105C2C drug resistance transporter, Bcr CflA HKX69_RS24120 ENOG4107S1E Beta-lactamase HKX69_RS24140 ENOG4106A0S HKX69_RS24150 ENOG4105DBE peroxidase HKX69_RS24155 ENOG410650H (LipO)protein HKX69_RS24190 ENOG4108478 ec 3.2.1.18 HKX69_RS24205 ENOG4107XZ0 Peptidase M50 HKX69_RS24230 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HKX69_RS24235 ENOG4105C57 major facilitator superfamily HKX69_RS24250 ENOG4105F27 Major Facilitator HKX69_RS24295 ENOG41081JD Transcriptional regulator HKX69_RS24305 ENOG4105C5F glutamine synthetase HKX69_RS24315 ENOG4105CXN decarboxylase HKX69_RS24330 ENOG4105FBN Acid phosphatase HKX69_RS24340 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HKX69_RS24350 ENOG4105ETE Transcriptional regulator (LacI family HKX69_RS24360 ENOG4105D56 permease protein HKX69_RS24365 ENOG4105EG2 ABC transporter, permease HKX69_RS24370 ENOG4105CG3 alpha amylase, catalytic region HKX69_RS24410 ENOG41060BG Tetr family transcriptional regulator HKX69_RS24435 ENOG4105WH1 Two component transcriptional regulator luxr family HKX69_RS24450 ENOG4107NHD transcriptional regulator HKX69_RS24455 ENOG4107R5B glutamine synthetase HKX69_RS24465 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HKX69_RS24470 ENOG4106SPC secreted protein HKX69_RS24475 ENOG4108222 arsenate reductase HKX69_RS24500 ENOG4105D0M Protease HtpX homolog HKX69_RS24515 ENOG4105C5F glutamine synthetase HKX69_RS24535 ENOG4105GCH Cupin 2 Conserved Barrel Domain Protein HKX69_RS24545 ENOG4108PDG Beta-ketoacyl synthase HKX69_RS24550 ENOG41079R3 acyl carrier protein HKX69_RS24555 ENOG4108Y5I Cyclase dehydrase HKX69_RS24560 ENOG4105KTE polyketide synthesis cyclase HKX69_RS24585 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HKX69_RS24590 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HKX69_RS24630 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HKX69_RS24650 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HKX69_RS24655 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HKX69_RS24670 ENOG4105CRK lysyL-tRNA synthetase HKX69_RS24675 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HKX69_RS24685 ENOG4108YZT Adenosylcobinamide kinase HKX69_RS24695 ENOG4105C0H protease HKX69_RS24725 ENOG4105WH1 Two component transcriptional regulator luxr family HKX69_RS24735 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HKX69_RS24755 ENOG4107T4Z adenosine kinase HKX69_RS24765 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HKX69_RS24770 ENOG4105BZ9 Cytochrome C oxidase, subunit I HKX69_RS24775 ENOG4105MCD Part of cytochrome c oxidase, its function is HKX69_RS24780 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HKX69_RS24790 ENOG4105CCU oxidase (Subunit III) HKX69_RS24795 ENOG4107UDY cytochrome C HKX69_RS24800 ENOG4107EUI c reductase, iron-sulfur HKX69_RS24805 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HKX69_RS24810 ENOG4108I0Q anthranilate phosphoribosyltransferase HKX69_RS24815 ENOG4105C9B Cysteine desulfurase HKX69_RS24885 ENOG4105D0U Arsenite-activated ATPase (ArsA) HKX69_RS24895 ENOG4105DKQ ROK family HKX69_RS24920 ENOG4105ENE Histidine kinase HKX69_RS24930 ENOG4105CTQ phosphohexokinase HKX69_RS24945 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HKX69_RS24955 ENOG4108UQY Iron-storage protein HKX69_RS24970 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HKX69_RS24980 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HKX69_RS25010 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HKX69_RS25035 ENOG4107Z3H Transcriptional regulator, TetR family HKX69_RS25040 ENOG4105ECB domain protein HKX69_RS25045 ENOG4105FDK ABC transporter HKX69_RS25055 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HKX69_RS25075 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HKX69_RS25085 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HKX69_RS25095 ENOG4105CJN penicillin-binding protein HKX69_RS25100 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HKX69_RS25110 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HKX69_RS25115 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HKX69_RS25125 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HKX69_RS25135 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HKX69_RS25140 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HKX69_RS25145 ENOG4105DFA alanine racemase domain protein HKX69_RS25150 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HKX69_RS25160 ENOG4107VQS DivIVA family HKX69_RS25165 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HKX69_RS25175 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HKX69_RS25230 ENOG4105C0B DNA polymerase III (alpha subunit) HKX69_RS25260 ENOG4108Z66 YbaK ebsC protein HKX69_RS25280 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HKX69_RS25285 ENOG4105CIH Imidazole acetol-phosphate transaminase HKX69_RS25290 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HKX69_RS25300 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HKX69_RS25305 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HKX69_RS25310 ENOG4108176 endoribonuclease L-psp HKX69_RS25315 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HKX69_RS25330 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase HKX69_RS25340 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HKX69_RS25365 ENOG4105DK0 Indole-3-glycerol phosphate synthase HKX69_RS25375 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HKX69_RS25380 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HKX69_RS25390 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HKX69_RS25395 ENOG4105CI0 Citrate lyase HKX69_RS25400 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HKX69_RS25405 ENOG4108RVA ribokinase HKX69_RS25425 ENOG41065RQ ADP-ribosylation crystallin J1 HKX69_RS25435 ENOG4105CBC glutamate synthase HKX69_RS25445 ENOG4105MUA Resistance protein HKX69_RS25465 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HKX69_RS25485 ENOG4105CGH 5'-nucleotidase HKX69_RS25510 ENOG4108IV0 ABC, transporter HKX69_RS25515 ENOG4105C0Z ABC transporter HKX69_RS25520 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HKX69_RS25525 ENOG4105C32 Amino acid ABC transporter (Permease) HKX69_RS25545 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HKX69_RS25575 ENOG4105CQ7 ATP-dependent helicase HKX69_RS25580 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HKX69_RS25585 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HKX69_RS25600 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HKX69_RS25620 ENOG4108D32 Methyltransferase HKX69_RS25640 ENOG4105K5X acetyltransferase HKX69_RS25670 ENOG4105BZ1 (ABC) transporter HKX69_RS25700 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HKX69_RS25705 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HKX69_RS25725 ENOG4108RYK Nad-dependent epimerase dehydratase HKX69_RS25740 ENOG4105D7N magnesium and cobalt transport protein CorA HKX69_RS25745 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HKX69_RS25755 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HKX69_RS25765 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HKX69_RS25770 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HKX69_RS25775 ENOG4105BZU Histidine kinase HKX69_RS25780 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HKX69_RS25805 ENOG4105CSH Transporter HKX69_RS25810 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HKX69_RS25820 ENOG4105E5Q amino acid AbC transporter HKX69_RS25825 ENOG4107R0W ABC transporter HKX69_RS25840 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HKX69_RS25850 ENOG4105ETE Transcriptional regulator (LacI family HKX69_RS25865 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HKX69_RS25870 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HKX69_RS25875 ENOG4105CHW UPF0052 protein HKX69_RS25880 ENOG4105CIE May be required for sporulation (By similarity) HKX69_RS25890 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HKX69_RS25895 ENOG4105BZA Phosphoglycerate kinase HKX69_RS25900 ENOG4105CP7 Triose-phosphate isomerase HKX69_RS25920 ENOG4107QP8 phosphohexose isomerase HKX69_RS25935 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HKX69_RS25940 ENOG4105U3E Transcriptional regulator HKX69_RS25945 ENOG4107T3P ABC, transporter HKX69_RS25950 ENOG4105CG3 alpha amylase, catalytic region HKX69_RS25960 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component HKX69_RS25965 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HKX69_RS25975 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) HKX69_RS25990 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HKX69_RS26000 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HKX69_RS26020 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) HKX69_RS26030 ENOG4105CJ1 ABC, transporter HKX69_RS26035 ENOG4108AQF aminoglycoside N(3)-acetyltransferase HKX69_RS26050 ENOG4105JRK feS assembly protein SufD HKX69_RS26060 ENOG4105C3K feS assembly ATPase SufC HKX69_RS26065 ENOG4105C9B Cysteine desulfurase HKX69_RS26070 ENOG4108UNV SUF system FeS assembly protein, NifU family HKX69_RS26075 ENOG4105VG1 fes assembly suf system protein HKX69_RS26085 ENOG410814C multidrug resistance protein HKX69_RS26090 ENOG4108RFG Tetr family transcriptional regulator HKX69_RS26095 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) HKX69_RS26115 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HKX69_RS26155 ENOG4105XEA Tetr family transcriptional regulator HKX69_RS26165 ENOG4105CPQ Dehydrogenase HKX69_RS26185 ENOG4105E98 transcriptional regulator DeoR family HKX69_RS26190 ENOG4105E9Z Nad-dependent epimerase dehydratase HKX69_RS26230 ENOG4105G3Z GntR family transcriptional regulator HKX69_RS26235 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HKX69_RS26260 ENOG4105C7N Xanthine uracil vitamin C permease HKX69_RS26275 ENOG4107HP6 Transcriptional regulator HKX69_RS26300 ENOG4105EV8 ectoine hydroxylase HKX69_RS26305 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) HKX69_RS26310 ENOG4108JPW Aminotransferase HKX69_RS26315 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase HKX69_RS26320 ENOG4105C5R Aminotransferase HKX69_RS26325 ENOG4105CT1 (ABC) transporter HKX69_RS26330 ENOG4105EAD ABC transporter HKX69_RS26360 ENOG41081F0 Precorrin-8x methylmutase HKX69_RS26365 ENOG4105E4R Precorrin-3B C17-methyltransferase HKX69_RS26375 ENOG4105CIA precorrin-4 C(11)-methyltransferase HKX69_RS26390 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HKX69_RS26395 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HKX69_RS26405 ENOG4105CTK cobaltochelatase, cobn subunit HKX69_RS26410 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HKX69_RS26435 ENOG4107W7X Aldolase HKX69_RS26460 ENOG4105C5H ABC transporter HKX69_RS26480 ENOG4105VBF alkaline shock protein HKX69_RS26510 ENOG4105BZP glycoside hydrolase 15-related HKX69_RS26525 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HKX69_RS26540 ENOG4105E2A Dehydrogenase HKX69_RS26545 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F HKX69_RS26565 ENOG4107QN1 sodium solute HKX69_RS26570 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HKX69_RS26590 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HKX69_RS26615 ENOG4105CHR reductase HKX69_RS26630 ENOG4107YCY Transcriptional regulator HKX69_RS26650 ENOG4105EAC phosphoserine phosphatase HKX69_RS26655 ENOG4105IDI abc transporter atp-binding protein HKX69_RS26675 ENOG4105BZU Histidine kinase HKX69_RS26680 ENOG4105WH1 Two component transcriptional regulator luxr family HKX69_RS26695 ENOG4105DKW ABC transporter HKX69_RS26715 ENOG4108V1U phospholipid-binding protein HKX69_RS26725 ENOG4108VX5 3-methyladenine DNA glycosylase HKX69_RS26755 ENOG4105DSU hydrolase HKX69_RS26760 ENOG4105DQ5 transport system permease protein HKX69_RS26765 ENOG4105TVJ transport system, permease HKX69_RS26770 ENOG4105E0A ABC, transporter HKX69_RS26790 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HKX69_RS26795 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HKX69_RS26800 ENOG4107QPH glycogen) synthase HKX69_RS26815 ENOG4105BZP glycoside hydrolase 15-related HKX69_RS26820 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HKX69_RS26835 ENOG4105DCF alanine dehydrogenase HKX69_RS26850 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HKX69_RS26855 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HKX69_RS26860 ENOG4105FE9 pseudouridine synthase HKX69_RS26865 ENOG41065RQ ADP-ribosylation crystallin J1 HKX69_RS26870 ENOG410756H nucleotidyltransferase HKX69_RS26895 ENOG4105CAT Cytidine monophosphate kinase HKX69_RS26905 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HKX69_RS26920 ENOG4106839 domain protein HKX69_RS26930 ENOG4105BZ9 Cytochrome C oxidase, subunit I HKX69_RS26940 ENOG410841Q phosphoesterase PA-phosphatase related protein HKX69_RS26950 ENOG4105C57 major facilitator superfamily HKX69_RS26955 ENOG4105C1G acyl-Coa dehydrogenase HKX69_RS26960 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HKX69_RS27005 ENOG4105CDA abc transporter atp-binding protein HKX69_RS27015 ENOG4106NMR serine protease HKX69_RS27020 ENOG4105C0B DNA polymerase III (alpha subunit) HKX69_RS27035 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HKX69_RS27050 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HKX69_RS27065 ENOG4108TCJ secreted hydrolase HKX69_RS27070 ENOG41061MD high-affinity nickel-transporter HKX69_RS27085 ENOG4105K6V RNA polymerase HKX69_RS27090 ENOG4105RNG membrane HKX69_RS27100 ENOG4105IYB L-carnitine dehydratase bile acid-inducible protein F HKX69_RS27120 ENOG4105F1J Homogentisate 1,2-dioxygenase HKX69_RS27130 ENOG4108SGK Tetr family transcriptional regulator HKX69_RS27135 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HKX69_RS27140 ENOG4105D4T Citrate transporter HKX69_RS27180 ENOG4105C1G acyl-Coa dehydrogenase HKX69_RS27200 ENOG4108Z4X TRANSCRIPTIONal HKX69_RS27245 ENOG4105EHZ conserved protein UCP016719 HKX69_RS27255 ENOG4105CEY Amp-dependent synthetase and ligase HKX69_RS27260 ENOG4108IG5 Transcriptional regulator HKX69_RS27285 ENOG4105VG5 Membrane HKX69_RS27290 ENOG4105PTV Nudix Hydrolase HKX69_RS27315 ENOG4105CPQ Dehydrogenase HKX69_RS27320 ENOG4105CHR reductase HKX69_RS27325 ENOG4105C6Z Gluconate HKX69_RS27330 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HKX69_RS27335 ENOG4105C6F GntR Family Transcriptional Regulator HKX69_RS27340 ENOG4105K5B UPF0225 protein HKX69_RS27360 ENOG4105DCG PHP domain protein HKX69_RS27370 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HKX69_RS27380 ENOG4105S2J secreted protein HKX69_RS27400 ENOG4105CPC Aldo Keto reductase HKX69_RS27405 ENOG4105DYW oxidoreductase HKX69_RS27415 ENOG4105D7N magnesium and cobalt transport protein CorA HKX69_RS27435 ENOG4105C8N cysteinyl-tRNA synthetase HKX69_RS27445 ENOG4105JXH GntR family transcriptional regulator HKX69_RS27450 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HKX69_RS27455 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HKX69_RS27460 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HKX69_RS27465 ENOG4108K8U Glycerol operon regulatory protein HKX69_RS27470 ENOG4105C3R Methionine synthase HKX69_RS27475 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HKX69_RS27480 ENOG4108J59 Extracellular solute-binding protein, family 5 HKX69_RS27485 ENOG4105WH1 Two component transcriptional regulator luxr family HKX69_RS27515 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) HKX69_RS27520 ENOG4105E5F proteasome HKX69_RS27525 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) HKX69_RS27535 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HKX69_RS27540 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HKX69_RS27545 ENOG4105ETE Transcriptional regulator (LacI family HKX69_RS27555 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) HKX69_RS27590 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HKX69_RS27595 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HKX69_RS27630 ENOG4105D3G Pseudouridine synthase HKX69_RS27645 ENOG4105HFS 5'-3' exonuclease HKX69_RS27670 ENOG4108Z86 Glutamine amidotransferase HKX69_RS27675 ENOG41073TP transcriptional regulator HKX69_RS27680 ENOG4105C5F glutamine synthetase HKX69_RS27685 ENOG4105C26 Dehydrogenase HKX69_RS27725 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HKX69_RS27730 ENOG41084BS 50S ribosomal protein L35 HKX69_RS27735 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HKX69_RS27740 ENOG4108RWN rrna methyltransferase HKX69_RS27745 ENOG4105BZU Histidine kinase HKX69_RS27750 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HKX69_RS27755 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HKX69_RS27785 ENOG4105F32 YngK protein HKX69_RS27795 ENOG4105T38 integral membrane protein HKX69_RS27835 ENOG4105CKK Glycosyl transferase, family 2 HKX69_RS27845 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HKX69_RS27850 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HKX69_RS27855 ENOG4105CAS nag kinase HKX69_RS27860 ENOG4105C8Y Acetylornithine aminotransferase HKX69_RS27865 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HKX69_RS27900 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HKX69_RS27905 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HKX69_RS27910 ENOG4105BZU Histidine kinase HKX69_RS27930 ENOG4105CDH Citrulline--aspartate ligase HKX69_RS27935 ENOG4105CH7 arginosuccinase HKX69_RS27945 ENOG4105RJZ Transcriptional regulator HKX69_RS27950 ENOG4105C57 major facilitator superfamily HKX69_RS27955 ENOG4107R16 Multicopper oxidase HKX69_RS27960 ENOG4105CEY Amp-dependent synthetase and ligase HKX69_RS27990 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HKX69_RS27995 ENOG4108UMI ABC transporter, permease HKX69_RS28020 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HKX69_RS28025 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HKX69_RS28080 ENOG4105CRQ synthase (Component I) HKX69_RS28115 ENOG4105KF0 sporulation and cell division protein, SsgA HKX69_RS28145 ENOG4108JDX DNA polymerase iii, epsilon subunit HKX69_RS28160 ENOG4105C22 threonyL-tRNA synthetase HKX69_RS28185 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase HKX69_RS28190 ENOG4105E2K Glycosyl transferase (Group 1 HKX69_RS28200 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HKX69_RS28205 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HKX69_RS28210 ENOG4105CDY transcriptional regulatory protein HKX69_RS28215 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HKX69_RS28220 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HKX69_RS28225 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HKX69_RS28235 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HKX69_RS28240 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HKX69_RS28245 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HKX69_RS28250 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HKX69_RS28255 ENOG4105C99 atpase involved in dna repair HKX69_RS28260 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) HKX69_RS28270 ENOG4105CUT histidyl-tRNA synthetase HKX69_RS28285 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HKX69_RS28305 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HKX69_RS28310 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HKX69_RS28320 ENOG4105E2X shikimate dehydrogenase HKX69_RS28325 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HKX69_RS28330 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HKX69_RS28335 ENOG4105D49 3-dehydroquinate synthase HKX69_RS28345 ENOG4105DC7 peptidase M24 HKX69_RS28350 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HKX69_RS28355 ENOG410803B Involved in the transcription termination process (By similarity) HKX69_RS28365 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HKX69_RS28370 ENOG4105CXT aspartate transcarbamylase HKX69_RS28375 ENOG4105CD3 dihydroorotase HKX69_RS28385 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HKX69_RS28390 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HKX69_RS28395 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HKX69_RS28400 ENOG4105SKN orotidine 5''-phosphate decarboxylase HKX69_RS28410 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HKX69_RS28425 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HKX69_RS28440 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HKX69_RS28450 ENOG4105DJV ribulose-phosphate 3-epimerase HKX69_RS28455 ENOG4105DKT Transcriptional regulator HKX69_RS28475 ENOG4105CUB amino acid HKX69_RS28500 ENOG4105C2W permease HKX69_RS28520 ENOG4105E2R ROK family HKX69_RS28540 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HKX69_RS28545 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HKX69_RS28550 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase HKX69_RS28555 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HKX69_RS28615 ENOG4105C1G acyl-Coa dehydrogenase HKX69_RS28625 ENOG4105EW9 transcriptional regulator AsnC family HKX69_RS28635 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HKX69_RS28645 ENOG4105Q70 HKX69_RS28650 ENOG4105DEU major facilitator superfamily HKX69_RS28660 ENOG4108VW9 Membrane HKX69_RS28665 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HKX69_RS28680 ENOG4105JXB ankyrin repeat-containing protein HKX69_RS28695 ENOG4108MJN Glycosyl Transferase HKX69_RS28700 ENOG41090WU lipolytic protein G-D-S-L family HKX69_RS28710 ENOG4105P4J Allophanate hydrolase, subunit 1 HKX69_RS28715 ENOG4105E7W lamb ycsf family protein HKX69_RS28720 ENOG4105CFM UPF0317 protein HKX69_RS28760 ENOG4105GWZ Roadblock lc7 family protein HKX69_RS28780 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HKX69_RS28785 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HKX69_RS28790 ENOG4105BZU Histidine kinase HKX69_RS28805 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HKX69_RS28815 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HKX69_RS28865 ENOG4108UW8 fha domain-containing protein HKX69_RS28885 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HKX69_RS28895 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HKX69_RS28915 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HKX69_RS28940 ENOG4105DSG hydrolase family 43 HKX69_RS28965 ENOG4105JAB phenazine biosynthesis protein, phzf family HKX69_RS28995 ENOG4105CSW GntR family transcriptional regulator HKX69_RS29000 ENOG4108Q5Y Membrane HKX69_RS29030 ENOG41086KC Transcriptional regulator HKX69_RS29075 ENOG4105CHR reductase HKX69_RS29080 ENOG4105DEF Extracellular solute-binding protein, family 5 HKX69_RS29085 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HKX69_RS29095 ENOG4105EP9 oxidoreductase HKX69_RS29100 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HKX69_RS29120 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HKX69_RS29130 ENOG4105CHU acetyl-coa acetyltransferase HKX69_RS29145 ENOG4105E2A Dehydrogenase HKX69_RS29150 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HKX69_RS29195 ENOG4108Z0R Transferase HKX69_RS29200 ENOG4108UW5 maltose o-acetyltransferase HKX69_RS29225 ENOG41082SX arsR family transcriptional regulator HKX69_RS29235 ENOG4107QTZ amino acid HKX69_RS29240 ENOG4105K4P CoA-binding domain protein HKX69_RS29255 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HKX69_RS29265 ENOG4105EYH Exonuclease HKX69_RS29295 ENOG4105WH1 Two component transcriptional regulator luxr family HKX69_RS29300 ENOG4105BZU Histidine kinase HKX69_RS29315 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase HKX69_RS29330 ENOG4108PSK reductase HKX69_RS29360 ENOG4106HB6 Alpha beta hydrolase HKX69_RS29370 ENOG4108KPJ rna polymerase sigma factor HKX69_RS29375 ENOG4105FDP GntR family transcriptional regulator HKX69_RS29380 ENOG4105DKQ ROK family HKX69_RS29385 ENOG4105WH1 Two component transcriptional regulator luxr family HKX69_RS29390 ENOG4105BZU Histidine kinase HKX69_RS29410 ENOG4108VCA G U mismatch-specific DNA glycosylase HKX69_RS29415 ENOG4105C83 adenylosuccinate lyase HKX69_RS29620 ENOG4108R6G acetyltransferase HKX69_RS29635 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HKX69_RS29640 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HKX69_RS29645 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HKX69_RS29650 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HKX69_RS29655 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HKX69_RS29695 ENOG4108YZ9 Urea amidohydrolase subunit gamma HKX69_RS29700 ENOG4105KI2 Urea amidohydrolase subunit beta HKX69_RS29705 ENOG4105CQM Urea amidohydrolase subunit alpha HKX69_RS29735 ENOG4105F6E Acyl-transferase HKX69_RS29755 ENOG4105C8Y Acetylornithine aminotransferase HKX69_RS29760 ENOG4105CIK Amidinotransferase HKX69_RS29780 ENOG4105CTQ phosphohexokinase HKX69_RS29785 ENOG4105F1K Glutamine amidotransferase HKX69_RS29795 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HKX69_RS29805 ENOG4105C1G acyl-Coa dehydrogenase HKX69_RS29815 ENOG4106A3M Cytochrome p-450 HKX69_RS29820 ENOG41065KQ synthase HKX69_RS29840 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) HKX69_RS29845 ENOG4105C3M thioredoxin reductase HKX69_RS29855 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HKX69_RS29860 ENOG4105D2B acyl-CoA dehydrogenase HKX69_RS29865 ENOG4105D2B acyl-CoA dehydrogenase HKX69_RS29895 ENOG4106W5V Membrane HKX69_RS29905 ENOG4105F44 Two component transcriptional regulator, winged helix family HKX69_RS29910 ENOG4106F60 Histidine kinase HKX69_RS29920 ENOG4105DDW LysR family Transcriptional regulator HKX69_RS29930 ENOG4105C26 Dehydrogenase HKX69_RS29935 ENOG4107RR1 TRANSCRIPTIONal HKX69_RS29945 ENOG4107SCA Formamidase (EC 3.5.1.49) HKX69_RS29950 ENOG4105C85 amino acid HKX69_RS29955 ENOG4105E2R ROK family HKX69_RS29980 ENOG4105C0D helicase HKX69_RS30025 ENOG4105BZU Histidine kinase HKX69_RS30055 ENOG4105GWZ Roadblock lc7 family protein HKX69_RS30065 ENOG4105C29 acyl-CoA thioesterase HKX69_RS30090 ENOG4105BZ1 (ABC) transporter HKX69_RS30120 ENOG4105BZ1 (ABC) transporter HKX69_RS30125 ENOG4105HHA aminodeoxychorismate lyase HKX69_RS30130 ENOG4105F95 Monooxygenase HKX69_RS30135 ENOG4107ZED Uncharacterised protein family UPF0047 HKX69_RS30160 ENOG4107VXZ Hydrolase HKX69_RS30185 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HKX69_RS30205 ENOG4105CSU acyl-Coa dehydrogenase HKX69_RS30225 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HKX69_RS30230 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HKX69_RS30235 ENOG4105YVS arsR family transcriptional regulator HKX69_RS30240 ENOG4105C2W permease HKX69_RS30270 ENOG410841Q phosphoesterase PA-phosphatase related protein HKX69_RS30310 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HKX69_RS30355 ENOG4105C10 Electron transfer flavoprotein HKX69_RS30365 ENOG41060NJ transcriptional regulator HKX69_RS30375 ENOG4105EX0 alpha-galactosidase HKX69_RS30385 ENOG4105I1F Resistance protein HKX69_RS30395 ENOG4107PP3 Acetylornithine deacetylase HKX69_RS30400 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HKX69_RS30415 ENOG4105BZU Histidine kinase HKX69_RS30420 ENOG4105WH1 Two component transcriptional regulator luxr family HKX69_RS30440 ENOG4105CTZ aminopeptidase c HKX69_RS30450 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) HKX69_RS30460 ENOG4105DKQ ROK family HKX69_RS30520 ENOG4106A3M Cytochrome p-450 HKX69_RS30525 ENOG4106A3M Cytochrome p-450 HKX69_RS30530 ENOG4105E39 Enoyl-CoA hydratase HKX69_RS30540 ENOG4105MVE transcriptional regulator HKX69_RS30550 ENOG4106F1P AAA ATPase, central domain protein HKX69_RS30575 ENOG4107R8N Glycosyl transferase, family 2 HKX69_RS30620 ENOG4105D5G Transposase HKX69_RS30625 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HKX69_RS30630 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) HKX69_RS30635 ENOG4105BZU Histidine kinase HKX69_RS30640 ENOG4105WH1 Two component transcriptional regulator luxr family HKX69_RS30655 ENOG4105WH1 Two component transcriptional regulator luxr family HKX69_RS30660 ENOG4105BZU Histidine kinase HKX69_RS30675 ENOG410841Q phosphoesterase PA-phosphatase related protein HKX69_RS30680 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HKX69_RS30685 ENOG4105DQR SNARE associated Golgi HKX69_RS30710 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HKX69_RS30720 ENOG410667J hydrolase HKX69_RS30745 ENOG4105EQ0 Major Facilitator superfamily HKX69_RS30765 ENOG4108YIQ Alpha beta hydrolase HKX69_RS30770 ENOG4108YIQ Alpha beta hydrolase HKX69_RS30785 ENOG4105D2S major facilitator superfamily HKX69_RS30795 ENOG4105FP9 thiamine pyrophosphate HKX69_RS30805 ENOG4106A3M Cytochrome p-450 HKX69_RS30850 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HKX69_RS30865 ENOG4108SGR YheO domain-containing protein HKX69_RS30880 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HKX69_RS30895 ENOG4105KVH Transcriptional regulator HKX69_RS30900 ENOG4105K4I Scp-like extracellular HKX69_RS30940 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) HKX69_RS30950 ENOG4108UYE Lactoylglutathione lyase HKX69_RS30960 ENOG4105WH1 Two component transcriptional regulator luxr family HKX69_RS30970 ENOG4105ETE Transcriptional regulator (LacI family HKX69_RS30980 ENOG4105D56 permease protein HKX69_RS31010 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HKX69_RS31015 ENOG41073TP transcriptional regulator HKX69_RS31030 ENOG4108IJ0 Aspartate ammonia-lyase HKX69_RS31040 ENOG41090CE integral membrane protein HKX69_RS31045 ENOG4105DZ1 carboxypeptidase HKX69_RS31080 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HKX69_RS31085 ENOG4105FDP GntR family transcriptional regulator HKX69_RS31095 ENOG4105I82 acetyl xylan esterase HKX69_RS31130 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HKX69_RS31150 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HKX69_RS31165 ENOG4106R7G Glycoside hydrolase family 5 HKX69_RS31175 ENOG4105VDH Dihydroxyacetone kinase HKX69_RS31180 ENOG4108UTZ Dihydroxyacetone kinase HKX69_RS31185 ENOG4105CMT Dihydroxyacetone kinase HKX69_RS31190 ENOG4105C71 hydrolase family 65, central catalytic HKX69_RS31200 ENOG4106A3M Cytochrome p-450 HKX69_RS31225 ENOG4108IAJ Nad-dependent epimerase dehydratase HKX69_RS31240 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HKX69_RS31250 ENOG4105CPK Glycosyl transferase (Group 1 HKX69_RS31255 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HKX69_RS31260 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HKX69_RS31265 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HKX69_RS31295 ENOG4108YZG isomerase HKX69_RS31320 ENOG4107S1E Beta-lactamase HKX69_RS31325 ENOG4105CEY Amp-dependent synthetase and ligase HKX69_RS31335 ENOG4108KQ5 Integrase catalytic subunit HKX69_RS31340 ENOG4105WAB arsR family transcriptional regulator HKX69_RS31350 ENOG4108J2P Alpha beta hydrolase fold HKX69_RS31400 ENOG4105KF0 sporulation and cell division protein, SsgA HKX69_RS31405 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HKX69_RS31415 ENOG4105CAQ asparagine synthetase HKX69_RS31475 ENOG4105DKQ ROK family HKX69_RS31480 ENOG4107QTZ amino acid HKX69_RS31490 ENOG4105MHT Transcriptional regulator, ARSR family HKX69_RS31500 ENOG4105CVP deoxyribo-dipyrimidine photolyase HKX69_RS31505 ENOG4105CGD Nad-dependent epimerase dehydratase HKX69_RS31520 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HKX69_RS31535 ENOG4107S5I aldo keto reductase HKX69_RS31550 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase HKX69_RS31555 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HKX69_RS31565 ENOG4108M0I Transcriptional regulator HKX69_RS31570 ENOG4105CPC Aldo Keto reductase HKX69_RS31590 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HKX69_RS31595 ENOG4105WBV Transcriptional regulator HKX69_RS31615 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HKX69_RS31635 ENOG4105C0R drug resistance transporter emrb qaca subfamily HKX69_RS31655 ENOG4108R5S membrane HKX69_RS31665 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HKX69_RS31670 ENOG4107QPV Serine Threonine protein kinase HKX69_RS31705 ENOG4105D4Y metalloprotease HKX69_RS31725 ENOG4108YV4 Universal stress protein HKX69_RS31735 ENOG4105C5X domain protein HKX69_RS31775 ENOG4105BZU Histidine kinase HKX69_RS31835 ENOG4105CEP NADH dehydrogenase HKX69_RS31855 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) HKX69_RS31860 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HKX69_RS31865 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) HKX69_RS31875 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HKX69_RS31930 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HKX69_RS31950 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HKX69_RS31955 ENOG4108K8U Glycerol operon regulatory protein HKX69_RS31995 ENOG4105DQE DNA ligase HKX69_RS32000 ENOG4107S5I aldo keto reductase HKX69_RS32010 ENOG4105CV8 reductase HKX69_RS32025 ENOG4105DRS transport system, permease HKX69_RS32030 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HKX69_RS32040 ENOG4108HKT sucrose-6-phosphate hydrolase HKX69_RS32085 ENOG4107RTD sua5 ycio yrdc ywlc family protein HKX69_RS32180 ENOG4108KXM LysR family Transcriptional regulator HKX69_RS32185 ENOG4107MM9 BNR Asp-box repeat-containing protein HKX69_RS32210 ENOG4107S9D Alpha beta hydrolase HKX69_RS32230 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) HKX69_RS32245 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HKX69_RS32260 ENOG4105BZ9 Cytochrome C oxidase, subunit I HKX69_RS32285 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HKX69_RS32290 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HKX69_RS32305 ENOG4105BZU Histidine kinase HKX69_RS32325 ENOG4107T5V SNARE associated Golgi HKX69_RS32345 ENOG4105CPC Aldo Keto reductase HKX69_RS32350 ENOG4105CSH Transporter HKX69_RS32360 ENOG4107SVN transposase HKX69_RS32420 ENOG41066UM arsR family transcriptional regulator HKX69_RS32460 ENOG4105C02 permease HKX69_RS32495 ENOG4105F71 Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HKX69_RS32500 ENOG4108USZ hydrogenase HKX69_RS32505 ENOG4107RSS Hydrogenase accessory protein HypB HKX69_RS32520 ENOG4105CQS hydrogenase expression formation protein HypD HKX69_RS32525 ENOG4105C45 hydrogenase expression formation protein (HypE) HKX69_RS32530 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HKX69_RS32555 ENOG4105DPX Hydrogenase, large subunit HKX69_RS32575 ENOG4105CN8 Transcriptional regulator HKX69_RS32590 ENOG4105DG6 mannose-6-phosphate isomerase HKX69_RS32605 ENOG4108PJD permease HKX69_RS32615 ENOG4108KQ5 Integrase catalytic subunit HKX69_RS32630 ENOG4107U9T Pfam:Ribonuclease_BN HKX69_RS32635 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HKX69_RS32660 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HKX69_RS32705 ENOG4108JA1 polyketide synthase HKX69_RS32715 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HKX69_RS32730 ENOG4105WH1 Two component transcriptional regulator luxr family HKX69_RS32740 ENOG4105DTD Dehydrogenase HKX69_RS32750 ENOG4106YKD Cytochrome p-450 HKX69_RS32795 ENOG4105DJI Methylaspartate mutase, E subunit HKX69_RS32820 ENOG4105EEM helicase HKX69_RS32840 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) HKX69_RS32845 ENOG4105ETE Transcriptional regulator (LacI family HKX69_RS32915 ENOG4107YHD transcriptional regulator HKX69_RS32935 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HKX69_RS32985 ENOG4105CD5 CoA-binding domain protein HKX69_RS33000 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HKX69_RS33020 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HKX69_RS33035 ENOG4105E2A Dehydrogenase HKX69_RS33065 ENOG4108YV4 Universal stress protein HKX69_RS33115 ENOG4108JIQ Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) HKX69_RS33120 ENOG4108JIP Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) HKX69_RS33160 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HKX69_RS33165 ENOG4107VEG TrkA-N domain protein HKX69_RS33175 ENOG4108YV4 Universal stress protein HKX69_RS33235 ENOG4105CPP Dehydrogenase, E1 component HKX69_RS33250 ENOG4105E2A Dehydrogenase HKX69_RS33280 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HKX69_RS33305 ENOG4105D5G Transposase HKX69_RS33315 ENOG4105D5G Transposase HKX69_RS33330 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HKX69_RS33340 ENOG4108W5M transcriptional regulator HKX69_RS33380 ENOG4105ECQ AraC Family Transcriptional Regulator HKX69_RS33385 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) HKX69_RS33390 ENOG4105CS1 NAD(P)H quinone oxidoreductase HKX69_RS33420 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HKX69_RS33445 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HKX69_RS33455 ENOG4105ECQ AraC Family Transcriptional Regulator HKX69_RS33465 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HKX69_RS33475 ENOG4107QRI Phosphoketolase HKX69_RS33510 ENOG4105EX0 alpha-galactosidase HKX69_RS33515 ENOG4105E2R ROK family HKX69_RS33560 ENOG4108YYH Nadph-dependent fmn reductase HKX69_RS33580 ENOG4105CZS beta-ketoacyl synthase HKX69_RS33600 ENOG4107SCK Monooxygenase HKX69_RS33615 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HKX69_RS33645 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HKX69_RS33650 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HKX69_RS33655 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HKX69_RS33665 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HKX69_RS33675 ENOG4105KHC sulfurtransferase HKX69_RS33680 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HKX69_RS33700 ENOG4107SCK Monooxygenase HKX69_RS33720 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HKX69_RS33735 ENOG4107R6F Alpha Beta Hydrolase Fold protein HKX69_RS33750 ENOG4107QNJ CoA-transferase subunit B HKX69_RS33760 ENOG4105CHU acetyl-coa acetyltransferase HKX69_RS33765 ENOG4107RSM transcriptional regulator HKX69_RS33770 ENOG4108KPW sugar kinase HKX69_RS33780 ENOG4105D38 putrescine abc transporter HKX69_RS33785 ENOG4105F38 ABC transporter, permease HKX69_RS33795 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HKX69_RS33800 ENOG4105ETE Transcriptional regulator (LacI family HKX69_RS33825 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HKX69_RS33830 ENOG4105K56 Transcriptional regulator HKX69_RS33855 ENOG4105JSC dimethylmenaquinone methyltransferase HKX69_RS33860 ENOG4107HP6 Transcriptional regulator HKX69_RS33865 ENOG4108JQ1 Dehydrogenase HKX69_RS33880 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HKX69_RS33900 ENOG4105FDF Could be involved in DNA repair (By similarity) HKX69_RS33955 ENOG4106NZI LysR family Transcriptional regulator HKX69_RS33990 ENOG4105CHR reductase HKX69_RS34045 ENOG4106F60 Histidine kinase HKX69_RS34135 ENOG4105CMD Transcriptional regulator, GntR family HKX69_RS34140 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of HKX69_RS34145 ENOG4105E70 isomerase HKX69_RS34160 ENOG4105D2N Aldolase HKX69_RS34170 ENOG4105E2D ec 3.2.1.52 HKX69_RS34190 ENOG4105FDP GntR family transcriptional regulator HKX69_RS34200 ENOG4108I0C methyltransferase HKX69_RS34260 ENOG4105CHR reductase HKX69_RS34300 ENOG4106A3M Cytochrome p-450 HKX69_RS34370 ENOG4108Z6Z Transcriptional regulator HKX69_RS34395 ENOG410905P Pyridoxamine 5-phosphate HKX69_RS34400 ENOG4105C7K acetolactate synthase HKX69_RS34405 ENOG4105CBC glutamate synthase HKX69_RS34425 ENOG4105D4Y metalloprotease HKX69_RS34440 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HKX69_RS34450 ENOG4105CPC Aldo Keto reductase HKX69_RS34455 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HKX69_RS34485 ENOG4105F1J Homogentisate 1,2-dioxygenase