locus-tag	class	description
HKX69_RS00110	COG0154	amidase activity
HKX69_RS00120	COG0446	pyridine nucleotide-disulphide oxidoreductase
HKX69_RS00120	COG1902	pentaerythritol trinitrate reductase activity
HKX69_RS00130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKX69_RS00135	COG1609	Transcriptional regulator
HKX69_RS00145	COG0765	amino acid transport
HKX69_RS00190	COG1012	belongs to the aldehyde dehydrogenase family
HKX69_RS00195	COG3903	Transcriptional regulator
HKX69_RS00195	COG3629	intracellular signal transduction
HKX69_RS00225	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HKX69_RS00280	COG0516	GMP reductase activity
HKX69_RS00280	COG0517	IMP dehydrogenase activity
HKX69_RS00295	COG0574	Belongs to the PEP-utilizing enzyme family
HKX69_RS00295	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HKX69_RS00305	COG1063	alcohol dehydrogenase
HKX69_RS00325	COG0589	response to stress
HKX69_RS00330	COG0617	tRNA 3'-terminal CCA addition
HKX69_RS00330	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HKX69_RS00330	COG0517	IMP dehydrogenase activity
HKX69_RS00340	COG0517	IMP dehydrogenase activity
HKX69_RS00380	COG1063	alcohol dehydrogenase
HKX69_RS00400	COG2801	Transposase and inactivated derivatives
HKX69_RS00400	COG3415	Transposase
HKX69_RS00425	COG0596	Alpha beta hydrolase
HKX69_RS00435	COG0515	serine threonine protein kinase
HKX69_RS00455	COG1595	DNA-templated transcription, initiation
HKX69_RS00470	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS00480	COG1982	Orn Lys Arg decarboxylase major
HKX69_RS00490	COG0531	amino acid
HKX69_RS00520	COG2172	sigma factor antagonist activity
HKX69_RS00525	COG1366	Belongs to the anti-sigma-factor antagonist family
HKX69_RS00545	COG1191	sigma factor activity
HKX69_RS00570	COG1366	Belongs to the anti-sigma-factor antagonist family
HKX69_RS00590	COG3340	Belongs to the peptidase S51 family
HKX69_RS00625	COG4865	methylaspartate mutase activity
HKX69_RS00630	COG0017	Asparaginyl-tRNA synthetase
HKX69_RS00635	COG0069	glutamate synthase activity
HKX69_RS00640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HKX69_RS00645	COG2423	ornithine cyclodeaminase activity
HKX69_RS00685	COG1335	isochorismatase
HKX69_RS00695	COG1309	transcriptional regulator
HKX69_RS00710	COG1309	transcriptional regulator
HKX69_RS00720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HKX69_RS00735	COG0655	NAD(P)H dehydrogenase (quinone) activity
HKX69_RS00740	COG0583	DNA-binding transcription factor activity
HKX69_RS00745	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS00765	COG3537	Alpha-1,2-mannosidase
HKX69_RS00780	COG4221	oxidoreductase activity
HKX69_RS00815	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS00820	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HKX69_RS00820	COG1017	nitric oxide dioxygenase activity
HKX69_RS00825	COG0584	glycerophosphoryl diester phosphodiesterase
HKX69_RS00865	COG3046	protein related to deoxyribodipyrimidine photolyase
HKX69_RS00870	COG0789	Transcriptional regulator
HKX69_RS00880	COG2409	Drug exporters of the RND superfamily
HKX69_RS00885	COG1846	Transcriptional regulator
HKX69_RS00890	COG2223	nitrite transmembrane transporter activity
HKX69_RS00915	COG1278	Cold shock
HKX69_RS00920	COG0596	Alpha beta hydrolase
HKX69_RS00930	COG0477	Major facilitator Superfamily
HKX69_RS00935	COG0667	Aldo Keto reductase
HKX69_RS00940	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS01030	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HKX69_RS01035	COG2197	response regulator
HKX69_RS01040	COG3851	Histidine kinase
HKX69_RS01050	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HKX69_RS01085	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HKX69_RS01110	COG1660	Displays ATPase and GTPase activities
HKX69_RS01125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HKX69_RS01160	COG1609	Transcriptional regulator
HKX69_RS01175	COG0395	ABC-type sugar transport system, permease component
HKX69_RS01205	COG0475	glutathione-regulated potassium exporter activity
HKX69_RS01220	COG0492	ferredoxin-NADP+ reductase activity
HKX69_RS01225	COG0318	PFAM AMP-dependent synthetase and ligase
HKX69_RS01230	COG0110	maltose O-acetyltransferase activity
HKX69_RS01245	COG3386	PFAM SMP-30 Gluconolaconase
HKX69_RS01250	COG0800	Aldolase
HKX69_RS01260	COG4948	Mandelate Racemase Muconate Lactonizing
HKX69_RS01265	COG2186	Transcriptional regulator
HKX69_RS01280	COG0395	ABC-type sugar transport system, permease component
HKX69_RS01285	COG1175	transmembrane transport
HKX69_RS01295	COG3345	alpha-galactosidase
HKX69_RS01305	COG0583	DNA-binding transcription factor activity
HKX69_RS01310	COG5640	endopeptidase activity
HKX69_RS01325	COG1120	ATPase activity
HKX69_RS01330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKX69_RS01390	COG0583	DNA-binding transcription factor activity
HKX69_RS01415	COG0326	Molecular chaperone. Has ATPase activity
HKX69_RS01435	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HKX69_RS01450	COG1082	Xylose isomerase domain protein TIM barrel
HKX69_RS01455	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HKX69_RS01470	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HKX69_RS01490	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HKX69_RS01495	COG1335	isochorismatase
HKX69_RS01500	COG2259	Doxx family
HKX69_RS01505	COG3619	membrane
HKX69_RS01515	COG2814	Major facilitator Superfamily
HKX69_RS01520	COG0028	Belongs to the TPP enzyme family
HKX69_RS01525	COG3608	succinylglutamate desuccinylase aspartoacylase
HKX69_RS01525	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HKX69_RS01560	COG0783	Belongs to the Dps family
HKX69_RS01590	COG1175	transmembrane transport
HKX69_RS01640	COG2409	Drug exporters of the RND superfamily
HKX69_RS01655	COG2814	Major facilitator Superfamily
HKX69_RS01675	COG1316	TRANSCRIPTIONal
HKX69_RS01680	COG4106	trans-aconitate 2-methyltransferase activity
HKX69_RS01690	COG0542	response to heat
HKX69_RS01705	COG0277	FAD linked oxidase domain protein
HKX69_RS01740	COG1733	regulation of RNA biosynthetic process
HKX69_RS01745	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HKX69_RS01760	COG3842	ATPase activity
HKX69_RS01765	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HKX69_RS01770	COG1176	ABC-type spermidine putrescine transport system, permease component I
HKX69_RS01775	COG1177	transmembrane transport
HKX69_RS01800	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HKX69_RS01820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HKX69_RS01830	COG2755	lipolytic protein G-D-S-L family
HKX69_RS01850	COG1175	transmembrane transport
HKX69_RS01855	COG0395	ABC-type sugar transport system, permease component
HKX69_RS01880	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS01895	COG0531	amino acid
HKX69_RS01920	COG0583	DNA-binding transcription factor activity
HKX69_RS01930	COG2197	response regulator
HKX69_RS01935	COG4585	Histidine kinase
HKX69_RS01980	COG1366	Belongs to the anti-sigma-factor antagonist family
HKX69_RS01985	COG1366	Belongs to the anti-sigma-factor antagonist family
HKX69_RS01990	COG2172	sigma factor antagonist activity
HKX69_RS02010	COG1982	Orn Lys Arg decarboxylase major
HKX69_RS02040	COG0248	Ppx GppA phosphatase
HKX69_RS02065	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HKX69_RS02095	COG2124	cytochrome p450
HKX69_RS02105	COG0667	Aldo Keto reductase
HKX69_RS02185	COG0456	acetyltransferase
HKX69_RS02235	COG3290	protein histidine kinase activity
HKX69_RS02250	COG3387	PFAM Glycoside hydrolase 15-related
HKX69_RS02265	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HKX69_RS02340	COG0367	asparagine synthase
HKX69_RS02360	COG1309	transcriptional regulator
HKX69_RS02390	COG1846	Transcriptional regulator
HKX69_RS02390	COG1940	carbohydrate kinase activity
HKX69_RS02410	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS02415	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS02440	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HKX69_RS02455	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HKX69_RS02485	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HKX69_RS02500	COG0300	oxidoreductase activity
HKX69_RS02510	COG0477	Major facilitator Superfamily
HKX69_RS02550	COG3251	PFAM MbtH domain protein
HKX69_RS02570	COG2124	cytochrome p450
HKX69_RS02620	COG0726	polysaccharide deacetylase
HKX69_RS02630	COG4221	oxidoreductase activity
HKX69_RS02650	COG2890	protein-(glutamine-N5) methyltransferase activity
HKX69_RS02690	COG3250	beta-galactosidase activity
HKX69_RS02700	COG1595	DNA-templated transcription, initiation
HKX69_RS02735	COG0667	Aldo Keto reductase
HKX69_RS02750	COG2124	cytochrome p450
HKX69_RS02770	COG0435	Glutathione S-transferase
HKX69_RS02805	COG1366	Belongs to the anti-sigma-factor antagonist family
HKX69_RS02815	COG1007	ATP synthesis coupled electron transport
HKX69_RS02820	COG1006	Multisubunit Na H antiporter MnhC subunit
HKX69_RS02865	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS02870	COG1796	DNA polymerase
HKX69_RS02870	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HKX69_RS02875	COG0546	phosphoglycolate phosphatase activity
HKX69_RS02890	COG1940	carbohydrate kinase activity
HKX69_RS02890	COG1846	Transcriptional regulator
HKX69_RS02920	COG2706	6-phosphogluconolactonase activity
HKX69_RS02940	COG1309	transcriptional regulator
HKX69_RS02950	COG1357	PFAM Pentapeptide repeats (8 copies)
HKX69_RS02965	COG1609	Transcriptional regulator
HKX69_RS02985	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKX69_RS02990	COG1129	ABC transporter
HKX69_RS02995	COG4952	isomerase
HKX69_RS03000	COG3347	Dehydrogenase
HKX69_RS03000	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS03005	COG1070	Carbohydrate kinase
HKX69_RS03010	COG0247	lactate metabolic process
HKX69_RS03015	COG1139	Iron-sulfur cluster binding protein
HKX69_RS03020	COG1556	Lactate utilization protein
HKX69_RS03040	COG1174	glycine betaine transport
HKX69_RS03050	COG0542	response to heat
HKX69_RS03100	COG1785	Belongs to the alkaline phosphatase family
HKX69_RS03120	COG2197	response regulator
HKX69_RS03125	COG4585	Histidine kinase
HKX69_RS03180	COG1501	Belongs to the glycosyl hydrolase 31 family
HKX69_RS03185	COG1653	transport
HKX69_RS03190	COG1175	transmembrane transport
HKX69_RS03195	COG0395	ABC-type sugar transport system, permease component
HKX69_RS03210	COG5002	protein histidine kinase activity
HKX69_RS03215	COG0745	RESPONSE REGULATOR receiver
HKX69_RS03250	COG0753	catalase activity
HKX69_RS03295	COG0242	peptide deformylase activity
HKX69_RS03305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HKX69_RS03310	COG1609	Transcriptional regulator
HKX69_RS03350	COG2268	Band 7 protein
HKX69_RS03385	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HKX69_RS03390	COG0121	glutamine amidotransferase
HKX69_RS03395	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HKX69_RS03400	COG2182	Extracellular solute-binding protein
HKX69_RS03405	COG3360	Dodecin
HKX69_RS03415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKX69_RS03445	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HKX69_RS03450	COG1053	succinate dehydrogenase
HKX69_RS03460	COG0583	DNA-binding transcription factor activity
HKX69_RS03470	COG0583	DNA-binding transcription factor activity
HKX69_RS03510	COG0726	polysaccharide deacetylase
HKX69_RS03520	COG0531	amino acid
HKX69_RS03545	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HKX69_RS03585	COG4948	Mandelate Racemase Muconate Lactonizing
HKX69_RS03595	COG1129	ABC transporter
HKX69_RS03600	COG4213	ABC transporter substrate-binding protein
HKX69_RS03615	COG0154	amidase activity
HKX69_RS03640	COG3537	Alpha-1,2-mannosidase
HKX69_RS03645	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HKX69_RS03650	COG0297	glycogen (starch) synthase activity
HKX69_RS03670	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HKX69_RS03680	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HKX69_RS03690	COG0071	Belongs to the small heat shock protein (HSP20) family
HKX69_RS03715	COG0628	permease
HKX69_RS03720	COG1597	lipid kinase activity
HKX69_RS03740	COG1408	metallophosphoesterase
HKX69_RS03760	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HKX69_RS03765	COG1335	isochorismatase
HKX69_RS03795	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HKX69_RS03800	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HKX69_RS03805	COG2080	2 iron, 2 sulfur cluster binding
HKX69_RS03815	COG1132	(ABC) transporter
HKX69_RS03825	COG1024	Enoyl-CoA hydratase
HKX69_RS03840	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HKX69_RS03850	COG0531	amino acid
HKX69_RS03855	COG0668	transmembrane transport
HKX69_RS03865	COG2838	Isocitrate dehydrogenase
HKX69_RS03900	COG1063	alcohol dehydrogenase
HKX69_RS03915	COG2197	response regulator
HKX69_RS03930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKX69_RS03935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKX69_RS03940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKX69_RS03945	COG0456	acetyltransferase
HKX69_RS03970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKX69_RS03985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKX69_RS03990	COG3938	Belongs to the proline racemase family
HKX69_RS04000	COG0531	amino acid
HKX69_RS04005	COG3275	phosphorelay sensor kinase activity
HKX69_RS04010	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HKX69_RS04030	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HKX69_RS04040	COG0477	Major facilitator Superfamily
HKX69_RS04060	COG1609	Transcriptional regulator
HKX69_RS04065	COG0673	inositol 2-dehydrogenase activity
HKX69_RS04070	COG1609	Transcriptional regulator
HKX69_RS04080	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS04085	COG0673	inositol 2-dehydrogenase activity
HKX69_RS04115	COG2188	Transcriptional regulator
HKX69_RS04120	COG1653	transport
HKX69_RS04130	COG0395	ABC-type sugar transport system, permease component
HKX69_RS04150	COG1472	Belongs to the glycosyl hydrolase 3 family
HKX69_RS04160	COG1175	transmembrane transport
HKX69_RS04180	COG0726	polysaccharide deacetylase
HKX69_RS04220	COG1011	Hydrolase
HKX69_RS04230	COG0318	PFAM AMP-dependent synthetase and ligase
HKX69_RS04235	COG0183	Belongs to the thiolase family
HKX69_RS04240	COG2267	carboxylic ester hydrolase activity
HKX69_RS04265	COG0561	phosphatase activity
HKX69_RS04300	COG3959	Transketolase, thiamine diphosphate binding domain
HKX69_RS04305	COG3958	Transketolase
HKX69_RS04330	COG0583	DNA-binding transcription factor activity
HKX69_RS04335	COG0156	8-amino-7-oxononanoate synthase activity
HKX69_RS04340	COG1063	alcohol dehydrogenase
HKX69_RS04375	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HKX69_RS04385	COG2755	lipolytic protein G-D-S-L family
HKX69_RS04425	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HKX69_RS04440	COG1657	PFAM Prenyltransferase squalene oxidase
HKX69_RS04450	COG1233	COG1233 Phytoene dehydrogenase and related
HKX69_RS04460	COG1562	ergosterol biosynthetic process
HKX69_RS04465	COG1134	teichoic acid transport
HKX69_RS04510	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HKX69_RS04520	COG1024	Enoyl-CoA hydratase
HKX69_RS04530	COG4977	sequence-specific DNA binding
HKX69_RS04535	COG2183	response to ionizing radiation
HKX69_RS04540	COG0488	(ABC) transporter
HKX69_RS04550	COG2936	dipeptidyl-peptidase activity
HKX69_RS04560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKX69_RS04565	COG1113	amino acid transport
HKX69_RS04575	COG1250	3-hydroxyacyl-CoA dehydrogenase
HKX69_RS04575	COG1024	Enoyl-CoA hydratase
HKX69_RS04580	COG0183	Belongs to the thiolase family
HKX69_RS04585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HKX69_RS04590	COG3268	Saccharopine dehydrogenase
HKX69_RS04595	COG2801	Transposase and inactivated derivatives
HKX69_RS04595	COG3415	Transposase
HKX69_RS04600	COG1515	deoxyribonuclease V activity
HKX69_RS04625	COG0488	(ABC) transporter
HKX69_RS04630	COG1834	amidinotransferase
HKX69_RS04660	COG1793	dna ligase
HKX69_RS04670	COG3485	protocatechuate 3,4-dioxygenase
HKX69_RS04675	COG3485	protocatechuate 3,4-dioxygenase
HKX69_RS04685	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HKX69_RS04695	COG1672	PFAM Archaeal ATPase
HKX69_RS04695	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HKX69_RS04725	COG3511	phospholipase C
HKX69_RS04735	COG0366	Alpha amylase catalytic
HKX69_RS04740	COG0395	ABC-type sugar transport system, permease component
HKX69_RS04745	COG1175	transmembrane transport
HKX69_RS04795	COG3469	chitinase activity
HKX69_RS04815	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HKX69_RS04830	COG0166	Belongs to the GPI family
HKX69_RS04835	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HKX69_RS04840	COG0588	phosphoglycerate mutase activity
HKX69_RS04860	COG2084	Dehydrogenase
HKX69_RS04865	COG3467	pyridoxamine 5'-phosphate
HKX69_RS04900	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HKX69_RS04920	COG0297	glycogen (starch) synthase activity
HKX69_RS04990	COG2723	6-phospho-beta-galactosidase activity
HKX69_RS04995	COG0395	ABC-type sugar transport system, permease component
HKX69_RS05000	COG1175	transmembrane transport
HKX69_RS05005	COG2182	Extracellular solute-binding protein
HKX69_RS05020	COG1012	belongs to the aldehyde dehydrogenase family
HKX69_RS05030	COG0045	succinate-CoA ligase (ADP-forming) activity
HKX69_RS05040	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HKX69_RS05050	COG2223	nitrite transmembrane transporter activity
HKX69_RS05065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HKX69_RS05075	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HKX69_RS05080	COG3383	formate dehydrogenase (NAD+) activity
HKX69_RS05085	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HKX69_RS05095	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HKX69_RS05100	COG1335	isochorismatase
HKX69_RS05105	COG1846	Transcriptional regulator
HKX69_RS05135	COG0656	L-ascorbic acid biosynthetic process
HKX69_RS05150	COG4221	oxidoreductase activity
HKX69_RS05155	COG4106	trans-aconitate 2-methyltransferase activity
HKX69_RS05165	COG5297	Belongs to the glycosyl hydrolase family 6
HKX69_RS05175	COG5297	Belongs to the glycosyl hydrolase family 6
HKX69_RS05175	COG4733	cellulase activity
HKX69_RS05200	COG2226	methyltransferase
HKX69_RS05205	COG2154	pterin-4-alpha-carbinolamine dehydratase
HKX69_RS05240	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HKX69_RS05265	COG0028	Belongs to the TPP enzyme family
HKX69_RS05280	COG0693	protein deglycase activity
HKX69_RS05295	COG0488	(ABC) transporter
HKX69_RS05360	COG1793	dna ligase
HKX69_RS05360	COG3285	dna ligase
HKX69_RS05375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKX69_RS05395	COG1619	proteins homologs of microcin C7 resistance protein MccF
HKX69_RS05405	COG3415	Transposase
HKX69_RS05405	COG2801	Transposase and inactivated derivatives
HKX69_RS05410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HKX69_RS05415	COG2362	D-Aminopeptidase
HKX69_RS05420	COG4106	trans-aconitate 2-methyltransferase activity
HKX69_RS05445	COG0456	acetyltransferase
HKX69_RS05455	COG1250	3-hydroxyacyl-CoA dehydrogenase
HKX69_RS05470	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HKX69_RS05470	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HKX69_RS05475	COG2301	Belongs to the HpcH HpaI aldolase family
HKX69_RS05485	COG1960	acyl-CoA dehydrogenase activity
HKX69_RS05490	COG0688	phosphatidylethanolamine metabolic process
HKX69_RS05500	COG1929	Belongs to the glycerate kinase type-1 family
HKX69_RS05515	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HKX69_RS05530	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HKX69_RS05590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HKX69_RS05590	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HKX69_RS05600	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HKX69_RS05610	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKX69_RS05765	COG5280	Phage tail tape measure protein TP901
HKX69_RS05765	COG3953	SLT domain
HKX69_RS05975	COG0095	Lipoate-protein ligase
HKX69_RS05985	COG1953	Uracil, thiamine, allantoin
HKX69_RS05995	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HKX69_RS06010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HKX69_RS06030	COG0542	response to heat
HKX69_RS06035	COG0405	Gamma-glutamyltransferase
HKX69_RS06065	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HKX69_RS06095	COG1302	Protein conserved in bacteria
HKX69_RS06135	COG0330	HflC and HflK could
HKX69_RS06140	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HKX69_RS06240	COG1473	amidohydrolase
HKX69_RS06255	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HKX69_RS06260	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HKX69_RS06265	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HKX69_RS06280	COG0025	NhaP-type Na H and K H
HKX69_RS06340	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HKX69_RS06340	COG2124	cytochrome p450
HKX69_RS06370	COG0179	Fumarylacetoacetate (FAA) hydrolase
HKX69_RS06375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HKX69_RS06380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HKX69_RS06390	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HKX69_RS06445	COG0604	alcohol dehydrogenase
HKX69_RS06450	COG1595	DNA-templated transcription, initiation
HKX69_RS06480	COG2814	Major facilitator Superfamily
HKX69_RS06495	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HKX69_RS06505	COG1940	carbohydrate kinase activity
HKX69_RS06525	COG2188	Transcriptional regulator
HKX69_RS06530	COG0673	inositol 2-dehydrogenase activity
HKX69_RS06540	COG2197	response regulator
HKX69_RS06570	COG4266	Belongs to the allantoicase family
HKX69_RS06575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HKX69_RS06580	COG1414	Transcriptional regulator
HKX69_RS06615	COG4264	IucA IucC family
HKX69_RS06640	COG1733	regulation of RNA biosynthetic process
HKX69_RS06645	COG0436	Aminotransferase
HKX69_RS06660	COG0406	alpha-ribazole phosphatase activity
HKX69_RS06690	COG2233	PERMEase
HKX69_RS06700	COG2233	PERMEase
HKX69_RS06710	COG2351	hydroxyisourate hydrolase activity
HKX69_RS06730	COG3622	Belongs to the hyi family
HKX69_RS06735	COG2084	Dehydrogenase
HKX69_RS06740	COG0753	catalase activity
HKX69_RS06755	COG3960	tartronate-semialdehyde synthase activity
HKX69_RS06765	COG0318	PFAM AMP-dependent synthetase and ligase
HKX69_RS06770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HKX69_RS06775	COG2197	response regulator
HKX69_RS06800	COG0726	polysaccharide deacetylase
HKX69_RS06805	COG5634	Uncharacterized conserved protein (DUF2278)
HKX69_RS06825	COG2252	PERMEase
HKX69_RS06830	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HKX69_RS06845	COG3835	regulator
HKX69_RS06855	COG1802	Transcriptional regulator
HKX69_RS06875	COG0028	Belongs to the TPP enzyme family
HKX69_RS06895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HKX69_RS06905	COG1162	GTPase activity
HKX69_RS06955	COG2040	homocysteine
HKX69_RS06970	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HKX69_RS07000	COG1960	acyl-CoA dehydrogenase activity
HKX69_RS07030	COG0175	sulfate reduction
HKX69_RS07035	COG0529	Catalyzes the synthesis of activated sulfate
HKX69_RS07060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKX69_RS07060	COG1116	anion transmembrane transporter activity
HKX69_RS07065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKX69_RS07080	COG1100	Small GTP-binding protein
HKX69_RS07120	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HKX69_RS07125	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HKX69_RS07130	COG2409	Drug exporters of the RND superfamily
HKX69_RS07150	COG1175	transmembrane transport
HKX69_RS07190	COG0583	DNA-binding transcription factor activity
HKX69_RS07195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKX69_RS07295	COG0640	Transcriptional regulator
HKX69_RS07305	COG2986	histidine ammonia-lyase
HKX69_RS07310	COG1732	Glycine betaine
HKX69_RS07320	COG2018	Roadblock/LC7 domain
HKX69_RS07335	COG1174	glycine betaine transport
HKX69_RS07340	COG1174	glycine betaine transport
HKX69_RS07350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HKX69_RS07355	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HKX69_RS07375	COG2801	Transposase and inactivated derivatives
HKX69_RS07375	COG3415	Transposase
HKX69_RS07395	COG0330	HflC and HflK could
HKX69_RS07400	COG2326	polyphosphate kinase activity
HKX69_RS07405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKX69_RS07405	COG0723	plastoquinol--plastocyanin reductase activity
HKX69_RS07425	COG3842	ATPase activity
HKX69_RS07435	COG3220	belongs to the UPF0276 family
HKX69_RS07470	COG0446	pyridine nucleotide-disulphide oxidoreductase
HKX69_RS07485	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HKX69_RS07500	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HKX69_RS07505	COG0183	Belongs to the thiolase family
HKX69_RS07510	COG1250	3-hydroxyacyl-CoA dehydrogenase
HKX69_RS07510	COG1024	Enoyl-CoA hydratase
HKX69_RS07535	COG0531	amino acid
HKX69_RS07540	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HKX69_RS07545	COG4214	carbohydrate transport
HKX69_RS07555	COG4213	ABC transporter substrate-binding protein
HKX69_RS07560	COG1940	carbohydrate kinase activity
HKX69_RS07565	COG0395	ABC-type sugar transport system, permease component
HKX69_RS07570	COG1175	transmembrane transport
HKX69_RS07575	COG1653	transport
HKX69_RS07590	COG3537	Alpha-1,2-mannosidase
HKX69_RS07595	COG0484	heat shock protein binding
HKX69_RS07600	COG0443	Heat shock 70 kDa protein
HKX69_RS07605	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HKX69_RS07610	COG3290	protein histidine kinase activity
HKX69_RS07615	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HKX69_RS07620	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HKX69_RS07625	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HKX69_RS07645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKX69_RS07660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HKX69_RS07690	COG1472	Belongs to the glycosyl hydrolase 3 family
HKX69_RS07695	COG0395	ABC-type sugar transport system, permease component
HKX69_RS07700	COG1175	transmembrane transport
HKX69_RS07705	COG2182	Extracellular solute-binding protein
HKX69_RS07710	COG2188	Transcriptional regulator
HKX69_RS07740	COG1902	pentaerythritol trinitrate reductase activity
HKX69_RS07745	COG1024	Enoyl-CoA hydratase
HKX69_RS07755	COG0531	amino acid
HKX69_RS07760	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HKX69_RS07810	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HKX69_RS07860	COG1799	cell septum assembly
HKX69_RS07900	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HKX69_RS07920	COG0367	asparagine synthase
HKX69_RS07945	COG0438	transferase activity, transferring glycosyl groups
HKX69_RS07955	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HKX69_RS07970	COG4310	Domain of unknown function (DUF2172)
HKX69_RS07980	COG0463	Glycosyl transferase, family 2
HKX69_RS07990	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HKX69_RS07995	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HKX69_RS08015	COG3693	PFAM glycoside hydrolase, family 10
HKX69_RS08040	COG1834	amidinotransferase
HKX69_RS08075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKX69_RS08085	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HKX69_RS08115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKX69_RS08120	COG1063	alcohol dehydrogenase
HKX69_RS08125	COG5285	phytanoyl-CoA dioxygenase
HKX69_RS08185	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HKX69_RS08190	COG0531	amino acid
HKX69_RS08200	COG0569	domain protein
HKX69_RS08230	COG1136	(ABC) transporter
HKX69_RS08240	COG0756	dUTP diphosphatase activity
HKX69_RS08265	COG2205	protein histidine kinase activity
HKX69_RS08270	COG0745	RESPONSE REGULATOR receiver
HKX69_RS08280	COG0483	inositol monophosphate 1-phosphatase activity
HKX69_RS08320	COG1435	thymidine kinase activity
HKX69_RS08340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKX69_RS08345	COG1802	Transcriptional regulator
HKX69_RS08360	COG0612	Peptidase, M16
HKX69_RS08365	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HKX69_RS08370	COG0523	cobalamin synthesis protein
HKX69_RS08375	COG0372	Belongs to the citrate synthase family
HKX69_RS08390	COG3290	protein histidine kinase activity
HKX69_RS08395	COG4565	transcriptional regulatory protein
HKX69_RS08405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKX69_RS08420	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HKX69_RS08430	COG2197	response regulator
HKX69_RS08445	COG0187	DNA topoisomerase II activity
HKX69_RS08455	COG5640	endopeptidase activity
HKX69_RS08460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HKX69_RS08465	COG1802	Transcriptional regulator
HKX69_RS08505	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HKX69_RS08540	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKX69_RS08545	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HKX69_RS08550	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HKX69_RS08580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HKX69_RS08590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HKX69_RS08595	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HKX69_RS08605	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HKX69_RS08625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HKX69_RS08645	COG3469	chitinase activity
HKX69_RS08665	COG2358	TRAP transporter, solute receptor (TAXI family
HKX69_RS08670	COG2205	protein histidine kinase activity
HKX69_RS08675	COG0745	RESPONSE REGULATOR receiver
HKX69_RS08680	COG1126	abc transporter atp-binding protein
HKX69_RS08685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKX69_RS08690	COG0765	amino acid transport
HKX69_RS08695	COG0765	amino acid transport
HKX69_RS08725	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HKX69_RS08740	COG0628	permease
HKX69_RS08760	COG1201	RNA secondary structure unwinding
HKX69_RS08765	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HKX69_RS08775	COG0783	Belongs to the Dps family
HKX69_RS08780	COG1396	sequence-specific DNA binding
HKX69_RS08785	COG1058	Belongs to the CinA family
HKX69_RS08785	COG1546	Belongs to the CinA family
HKX69_RS08795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HKX69_RS08805	COG1674	ftsk spoiiie
HKX69_RS08820	COG2208	phosphoserine phosphatase activity
HKX69_RS08820	COG2770	Histidine kinase
HKX69_RS08850	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HKX69_RS08855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKX69_RS08860	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HKX69_RS08880	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HKX69_RS08885	COG0612	Peptidase, M16
HKX69_RS08890	COG1185	polyribonucleotide nucleotidyltransferase activity
HKX69_RS08895	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HKX69_RS08910	COG1674	ftsk spoiiie
HKX69_RS08940	COG1404	Belongs to the peptidase S8 family
HKX69_RS08960	COG1404	Belongs to the peptidase S8 family
HKX69_RS08965	COG3266	domain, Protein
HKX69_RS08980	COG0455	bacterial-type flagellum organization
HKX69_RS09000	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HKX69_RS09005	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HKX69_RS09015	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HKX69_RS09030	COG0779	Required for maturation of 30S ribosomal subunits
HKX69_RS09050	COG0442	prolyl-tRNA aminoacylation
HKX69_RS09055	COG1247	-acetyltransferase
HKX69_RS09065	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HKX69_RS09070	COG0750	zinc metalloprotease
HKX69_RS09075	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HKX69_RS09090	COG1609	Transcriptional regulator
HKX69_RS09100	COG1012	belongs to the aldehyde dehydrogenase family
HKX69_RS09140	COG3415	Transposase
HKX69_RS09140	COG2801	Transposase and inactivated derivatives
HKX69_RS09145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKX69_RS09150	COG1177	transmembrane transport
HKX69_RS09155	COG1176	ABC-type spermidine putrescine transport system, permease component I
HKX69_RS09160	COG3842	ATPase activity
HKX69_RS09185	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HKX69_RS09190	COG0584	glycerophosphoryl diester phosphodiesterase
HKX69_RS09210	COG1414	Transcriptional regulator
HKX69_RS09230	COG0395	ABC-type sugar transport system, permease component
HKX69_RS09240	COG1012	belongs to the aldehyde dehydrogenase family
HKX69_RS09250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HKX69_RS09255	COG4181	ATPase activity
HKX69_RS09285	COG3842	ATPase activity
HKX69_RS09290	COG4208	sulfate ABC transporter
HKX69_RS09300	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HKX69_RS09310	COG2124	cytochrome p450
HKX69_RS09315	COG0575	Belongs to the CDS family
HKX69_RS09320	COG0233	cytoplasmic translational termination
HKX69_RS09325	COG0528	UMP kinase activity
HKX69_RS09330	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HKX69_RS09335	COG0052	Belongs to the universal ribosomal protein uS2 family
HKX69_RS09350	COG1191	sigma factor activity
HKX69_RS09385	COG0792	nuclease activity
HKX69_RS09395	COG1051	belongs to the nudix hydrolase family
HKX69_RS09405	COG0681	Belongs to the peptidase S26 family
HKX69_RS09420	COG0335	large ribosomal subunit rRNA binding
HKX69_RS09425	COG0336	Belongs to the RNA methyltransferase TrmD family
HKX69_RS09430	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HKX69_RS09435	COG1837	Belongs to the UPF0109 family
HKX69_RS09440	COG0228	four-way junction DNA binding
HKX69_RS09460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HKX69_RS09470	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HKX69_RS09510	COG0477	Major facilitator Superfamily
HKX69_RS09515	COG1196	nuclear chromosome segregation
HKX69_RS09525	COG1254	Belongs to the acylphosphatase family
HKX69_RS09535	COG0655	NAD(P)H dehydrogenase (quinone) activity
HKX69_RS09540	COG1733	regulation of RNA biosynthetic process
HKX69_RS09545	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HKX69_RS09550	COG0571	ribonuclease III activity
HKX69_RS09555	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HKX69_RS09570	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HKX69_RS09575	COG0742	ribosomal rna small subunit methyltransferase
HKX69_RS09585	COG0326	Molecular chaperone. Has ATPase activity
HKX69_RS09595	COG1461	Dihydroxyacetone kinase
HKX69_RS09600	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HKX69_RS09605	COG0351	phosphomethylpyrimidine kinase
HKX69_RS09625	COG1181	Belongs to the D-alanine--D-alanine ligase family
HKX69_RS09630	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HKX69_RS09640	COG1920	GTP binding
HKX69_RS09650	COG0776	regulation of translation
HKX69_RS09660	COG0066	3-isopropylmalate dehydratase activity
HKX69_RS09665	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HKX69_RS09670	COG1414	Transcriptional regulator
HKX69_RS09730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HKX69_RS09735	COG0179	Fumarylacetoacetate (FAA) hydrolase
HKX69_RS09745	COG5002	protein histidine kinase activity
HKX69_RS09750	COG2018	Roadblock/LC7 domain
HKX69_RS09770	COG2018	Roadblock/LC7 domain
HKX69_RS09785	COG2826	transposase and inactivated derivatives, IS30 family
HKX69_RS09795	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HKX69_RS09800	COG5492	domain, Protein
HKX69_RS09810	COG2353	YceI-like domain
HKX69_RS09860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HKX69_RS09865	COG0477	Major facilitator Superfamily
HKX69_RS09875	COG2957	Belongs to the agmatine deiminase family
HKX69_RS09880	COG0804	urea catabolic process
HKX69_RS09885	COG0832	Belongs to the urease beta subunit family
HKX69_RS09885	COG0831	urea catabolic process
HKX69_RS09890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HKX69_RS09895	COG0473	3-isopropylmalate dehydrogenase activity
HKX69_RS09910	COG1012	belongs to the aldehyde dehydrogenase family
HKX69_RS09915	COG0506	proline dehydrogenase activity
HKX69_RS09930	COG0477	Major facilitator Superfamily
HKX69_RS09935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HKX69_RS09940	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HKX69_RS09945	COG0440	acetolactate synthase activity
HKX69_RS09955	COG5001	Diguanylate cyclase
HKX69_RS09965	COG0667	Aldo Keto reductase
HKX69_RS09970	COG2133	pyrroloquinoline quinone binding
HKX69_RS09980	COG2197	response regulator
HKX69_RS09995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HKX69_RS10005	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HKX69_RS10015	COG0154	amidase activity
HKX69_RS10020	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HKX69_RS10045	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HKX69_RS10055	COG4221	oxidoreductase activity
HKX69_RS10060	COG1611	Belongs to the LOG family
HKX69_RS10075	COG0482	sulfurtransferase activity
HKX69_RS10105	COG2378	regulation of single-species biofilm formation
HKX69_RS10125	COG2860	membrane
HKX69_RS10135	COG4608	Belongs to the ABC transporter superfamily
HKX69_RS10140	COG0444	Belongs to the ABC transporter superfamily
HKX69_RS10150	COG0747	negative chemotaxis
HKX69_RS10155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HKX69_RS10175	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HKX69_RS10180	COG0509	glycine decarboxylation via glycine cleavage system
HKX69_RS10185	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HKX69_RS10190	COG1760	l-serine dehydratase
HKX69_RS10205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HKX69_RS10210	COG1119	ATPase activity
HKX69_RS10250	COG1376	ErfK ybiS ycfS ynhG family protein
HKX69_RS10255	COG1376	ErfK ybiS ycfS ynhG family protein
HKX69_RS10290	COG1132	(ABC) transporter
HKX69_RS10295	COG1132	(ABC) transporter
HKX69_RS10300	COG1132	(ABC) transporter
HKX69_RS10305	COG1132	(ABC) transporter
HKX69_RS10345	COG0058	SHG alpha-glucan phosphorylase activity
HKX69_RS10360	COG0366	Alpha amylase catalytic
HKX69_RS10370	COG3281	Trehalose synthase
HKX69_RS10375	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HKX69_RS10395	COG0477	Major facilitator Superfamily
HKX69_RS10405	COG1301	dicarboxylic acid transport
HKX69_RS10410	COG3290	protein histidine kinase activity
HKX69_RS10415	COG4565	transcriptional regulatory protein
HKX69_RS10420	COG3629	intracellular signal transduction
HKX69_RS10420	COG3903	Transcriptional regulator
HKX69_RS10430	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HKX69_RS10460	COG1175	transmembrane transport
HKX69_RS10465	COG0395	ABC-type sugar transport system, permease component
HKX69_RS10475	COG0205	6-phosphofructokinase activity
HKX69_RS10480	COG0280	phosphate acetyltransferase
HKX69_RS10480	COG0857	belongs to the CobB CobQ family
HKX69_RS10485	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HKX69_RS10520	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HKX69_RS10520	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HKX69_RS10590	COG0183	Belongs to the thiolase family
HKX69_RS10610	COG1131	(ABC) transporter
HKX69_RS10645	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HKX69_RS10660	COG1250	3-hydroxyacyl-CoA dehydrogenase
HKX69_RS10680	COG2318	DinB family
HKX69_RS10690	COG4585	Histidine kinase
HKX69_RS10695	COG2197	response regulator
HKX69_RS10710	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HKX69_RS10715	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HKX69_RS10720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HKX69_RS10725	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HKX69_RS10730	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HKX69_RS10735	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HKX69_RS10740	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HKX69_RS10755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HKX69_RS10760	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HKX69_RS10765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HKX69_RS10775	COG2890	protein-(glutamine-N5) methyltransferase activity
HKX69_RS10780	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HKX69_RS10785	COG0254	rRNA binding
HKX69_RS10800	COG0083	homoserine kinase activity
HKX69_RS10805	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HKX69_RS10810	COG0460	homoserine dehydrogenase
HKX69_RS10815	COG0019	diaminopimelate decarboxylase activity
HKX69_RS10820	COG0018	arginyl-trna synthetase
HKX69_RS10940	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HKX69_RS10945	COG3285	dna ligase
HKX69_RS10945	COG1793	dna ligase
HKX69_RS10965	COG2205	protein histidine kinase activity
HKX69_RS10970	COG0772	Belongs to the SEDS family
HKX69_RS10975	COG0768	penicillin binding
HKX69_RS11055	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HKX69_RS11070	COG0745	RESPONSE REGULATOR receiver
HKX69_RS11075	COG2205	protein histidine kinase activity
HKX69_RS11080	COG0567	Dehydrogenase, E1 component
HKX69_RS11080	COG0508	dehydrogenase complex catalyzes the overall conversion of
HKX69_RS11105	COG2255	four-way junction helicase activity
HKX69_RS11145	COG0604	alcohol dehydrogenase
HKX69_RS11150	COG0281	malic enzyme
HKX69_RS11165	COG1126	abc transporter atp-binding protein
HKX69_RS11170	COG4106	trans-aconitate 2-methyltransferase activity
HKX69_RS11215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HKX69_RS11240	COG2172	sigma factor antagonist activity
HKX69_RS11255	COG1597	lipid kinase activity
HKX69_RS11275	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS11280	COG0363	glucosamine-6-phosphate deaminase activity
HKX69_RS11285	COG2188	Transcriptional regulator
HKX69_RS11315	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKX69_RS11330	COG2124	cytochrome p450
HKX69_RS11340	COG0242	peptide deformylase activity
HKX69_RS11360	COG5662	AntiSigma factor
HKX69_RS11365	COG1595	DNA-templated transcription, initiation
HKX69_RS11375	COG2135	peptidase activity
HKX69_RS11385	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HKX69_RS11395	COG2076	Multidrug Resistance protein
HKX69_RS11405	COG0483	inositol monophosphate 1-phosphatase activity
HKX69_RS11415	COG0753	catalase activity
HKX69_RS11440	COG1615	UPF0182 protein
HKX69_RS11450	COG3480	Lon protease (S16) C-terminal proteolytic domain
HKX69_RS11505	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HKX69_RS11540	COG2816	NAD+ diphosphatase activity
HKX69_RS11545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HKX69_RS11575	COG0596	Alpha beta hydrolase
HKX69_RS11615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HKX69_RS11620	COG0747	negative chemotaxis
HKX69_RS11660	COG0513	Belongs to the DEAD box helicase family
HKX69_RS11670	COG1432	Conserved Protein
HKX69_RS11680	COG2095	MarC family integral membrane protein
HKX69_RS11695	COG2814	Major facilitator Superfamily
HKX69_RS11705	COG0598	Magnesium transport protein CorA
HKX69_RS11750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HKX69_RS11755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HKX69_RS11765	COG1595	DNA-templated transcription, initiation
HKX69_RS11780	COG1024	Enoyl-CoA hydratase
HKX69_RS11785	COG0519	Catalyzes the synthesis of GMP from XMP
HKX69_RS11795	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HKX69_RS11800	COG1611	Belongs to the LOG family
HKX69_RS11805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HKX69_RS11840	COG2197	response regulator
HKX69_RS11845	COG4585	Histidine kinase
HKX69_RS11855	COG1131	(ABC) transporter
HKX69_RS11870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HKX69_RS11885	COG4608	Belongs to the ABC transporter superfamily
HKX69_RS11890	COG0444	Belongs to the ABC transporter superfamily
HKX69_RS11900	COG0601	transmembrane transport
HKX69_RS11915	COG0747	negative chemotaxis
HKX69_RS11920	COG0601	transmembrane transport
HKX69_RS11925	COG0444	Belongs to the ABC transporter superfamily
HKX69_RS11930	COG4608	Belongs to the ABC transporter superfamily
HKX69_RS11940	COG4608	Belongs to the ABC transporter superfamily
HKX69_RS11945	COG0444	Belongs to the ABC transporter superfamily
HKX69_RS11950	COG0601	transmembrane transport
HKX69_RS11955	COG4166	transmembrane transport
HKX69_RS11985	COG1053	succinate dehydrogenase
HKX69_RS11990	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HKX69_RS12040	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HKX69_RS12065	COG0012	GTP binding
HKX69_RS12080	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HKX69_RS12090	COG1570	exodeoxyribonuclease VII activity
HKX69_RS12095	COG1722	exodeoxyribonuclease VII activity
HKX69_RS12100	COG0778	Nitroreductase
HKX69_RS12125	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HKX69_RS12125	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HKX69_RS12140	COG0114	fumarate hydratase activity
HKX69_RS12155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HKX69_RS12175	COG1136	(ABC) transporter
HKX69_RS12190	COG0450	alkyl hydroperoxide reductase
HKX69_RS12195	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HKX69_RS12205	COG0741	lytic transglycosylase activity
HKX69_RS12210	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HKX69_RS12215	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HKX69_RS12220	COG2226	methyltransferase
HKX69_RS12260	COG3920	Histidine kinase
HKX69_RS12290	COG2894	cell division
HKX69_RS12340	COG2610	gluconate transmembrane transporter activity
HKX69_RS12345	COG0251	oxidation-reduction process
HKX69_RS12350	COG1414	Transcriptional regulator
HKX69_RS12365	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HKX69_RS12380	COG0436	Aminotransferase
HKX69_RS12410	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HKX69_RS12420	COG1309	transcriptional regulator
HKX69_RS12435	COG1331	Highly conserved protein containing a thioredoxin domain
HKX69_RS12450	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HKX69_RS12460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HKX69_RS12475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HKX69_RS12480	COG2255	four-way junction helicase activity
HKX69_RS12485	COG1595	DNA-templated transcription, initiation
HKX69_RS12505	COG0501	Belongs to the peptidase M48B family
HKX69_RS12515	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HKX69_RS12535	COG1064	alcohol dehydrogenase
HKX69_RS12545	COG1404	Belongs to the peptidase S8 family
HKX69_RS12550	COG1136	(ABC) transporter
HKX69_RS12580	COG2986	histidine ammonia-lyase
HKX69_RS12590	COG1024	Enoyl-CoA hydratase
HKX69_RS12600	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HKX69_RS12610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HKX69_RS12620	COG0424	maF-like protein
HKX69_RS12630	COG4770	biotin carboxylase activity
HKX69_RS12655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKX69_RS12670	COG1012	belongs to the aldehyde dehydrogenase family
HKX69_RS12675	COG1012	belongs to the aldehyde dehydrogenase family
HKX69_RS12690	COG1595	DNA-templated transcription, initiation
HKX69_RS12695	COG0745	RESPONSE REGULATOR receiver
HKX69_RS12700	COG2205	protein histidine kinase activity
HKX69_RS12725	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HKX69_RS12735	COG0583	DNA-binding transcription factor activity
HKX69_RS12740	COG2814	Major facilitator Superfamily
HKX69_RS12790	COG1473	amidohydrolase
HKX69_RS12790	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HKX69_RS12825	COG2089	acid synthase
HKX69_RS12840	COG1216	Glycosyl transferase, family 2
HKX69_RS12855	COG1216	Glycosyl transferase, family 2
HKX69_RS12870	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HKX69_RS12870	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HKX69_RS12885	COG1595	DNA-templated transcription, initiation
HKX69_RS12915	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HKX69_RS12925	COG2009	succinate dehydrogenase
HKX69_RS12935	COG1053	succinate dehydrogenase
HKX69_RS12955	COG1309	transcriptional regulator
HKX69_RS12970	COG1408	metallophosphoesterase
HKX69_RS12985	COG1295	ribonuclease BN
HKX69_RS13000	COG0180	Tryptophanyl-tRNA synthetase
HKX69_RS13005	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HKX69_RS13010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HKX69_RS13025	COG0754	glutathionylspermidine amidase activity
HKX69_RS13040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKX69_RS13045	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HKX69_RS13060	COG4176	ABC-type proline glycine betaine transport system permease component
HKX69_RS13065	COG4175	Glycine betaine
HKX69_RS13065	COG0517	IMP dehydrogenase activity
HKX69_RS13075	COG1012	belongs to the aldehyde dehydrogenase family
HKX69_RS13085	COG0039	L-malate dehydrogenase activity
HKX69_RS13095	COG2197	response regulator
HKX69_RS13100	COG4585	Histidine kinase
HKX69_RS13110	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HKX69_RS13155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HKX69_RS13175	COG3251	PFAM MbtH domain protein
HKX69_RS13180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKX69_RS13190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HKX69_RS13195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKX69_RS13200	COG3903	Transcriptional regulator
HKX69_RS13200	COG3629	intracellular signal transduction
HKX69_RS13235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKX69_RS13250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HKX69_RS13255	COG0138	bifunctional purine biosynthesis protein purh
HKX69_RS13285	COG0045	succinate-CoA ligase (ADP-forming) activity
HKX69_RS13290	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HKX69_RS13300	COG0714	Associated with various cellular activities
HKX69_RS13315	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HKX69_RS13315	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HKX69_RS13325	COG0739	heme binding
HKX69_RS13350	COG2197	response regulator
HKX69_RS13390	COG0519	Catalyzes the synthesis of GMP from XMP
HKX69_RS13390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HKX69_RS13405	COG1012	belongs to the aldehyde dehydrogenase family
HKX69_RS13410	COG0515	serine threonine protein kinase
HKX69_RS13415	COG0515	serine threonine protein kinase
HKX69_RS13415	COG2815	serine threonine protein kinase
HKX69_RS13420	COG0515	serine threonine protein kinase
HKX69_RS13425	COG0515	serine threonine protein kinase
HKX69_RS13425	COG2815	serine threonine protein kinase
HKX69_RS13435	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HKX69_RS13445	COG0516	GMP reductase activity
HKX69_RS13455	COG1595	DNA-templated transcription, initiation
HKX69_RS13470	COG0583	DNA-binding transcription factor activity
HKX69_RS13480	COG4221	oxidoreductase activity
HKX69_RS13500	COG0459	protein refolding
HKX69_RS13510	COG0726	polysaccharide deacetylase
HKX69_RS13515	COG0726	polysaccharide deacetylase
HKX69_RS13525	COG4941	Belongs to the sigma-70 factor family
HKX69_RS13540	COG1609	Transcriptional regulator
HKX69_RS13550	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HKX69_RS13575	COG0802	atpase or kinase
HKX69_RS13585	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HKX69_RS13595	COG0736	holo-[acyl-carrier-protein] synthase activity
HKX69_RS13605	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HKX69_RS13610	COG1072	(Pantothenic acid kinase))
HKX69_RS13620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKX69_RS13625	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HKX69_RS13630	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HKX69_RS13645	COG0101	tRNA pseudouridine synthase activity
HKX69_RS13650	COG0203	ribosomal protein L17
HKX69_RS13655	COG0202	RNA polymerase activity
HKX69_RS13660	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HKX69_RS13665	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HKX69_RS13670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HKX69_RS13675	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HKX69_RS13685	COG0563	adenylate kinase activity
HKX69_RS13695	COG0200	Binds to the 23S rRNA
HKX69_RS13700	COG1841	ribosomal large subunit assembly
HKX69_RS13705	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HKX69_RS13710	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HKX69_RS13715	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HKX69_RS13720	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HKX69_RS13725	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HKX69_RS13730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HKX69_RS13735	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HKX69_RS13740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HKX69_RS13745	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HKX69_RS13750	COG0255	Belongs to the universal ribosomal protein uL29 family
HKX69_RS13755	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HKX69_RS13760	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HKX69_RS13765	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HKX69_RS13770	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HKX69_RS13775	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HKX69_RS13780	COG0089	rRNA binding
HKX69_RS13785	COG0088	Forms part of the polypeptide exit tunnel
HKX69_RS13790	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HKX69_RS13795	COG0051	transcription antitermination factor activity, RNA binding
HKX69_RS13815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HKX69_RS13820	COG0049	tRNA binding
HKX69_RS13825	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HKX69_RS13830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HKX69_RS13860	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HKX69_RS13865	COG0085	RNA polymerase activity
HKX69_RS13870	COG0222	ribosome binding
HKX69_RS13885	COG0081	regulation of translation
HKX69_RS13895	COG0250	Participates in transcription elongation, termination and antitermination
HKX69_RS13910	COG0436	Aminotransferase
HKX69_RS13915	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HKX69_RS13930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HKX69_RS13935	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HKX69_RS13940	COG0477	Major facilitator Superfamily
HKX69_RS13955	COG2030	dehydratase
HKX69_RS13960	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HKX69_RS13980	COG0702	epimerase
HKX69_RS14005	COG1666	GTP binding
HKX69_RS14025	COG0501	Belongs to the peptidase M48B family
HKX69_RS14030	COG1007	ATP synthesis coupled electron transport
HKX69_RS14035	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HKX69_RS14040	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HKX69_RS14045	COG0713	ATP synthesis coupled electron transport
HKX69_RS14050	COG0839	Belongs to the complex I subunit 6 family
HKX69_RS14055	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HKX69_RS14060	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HKX69_RS14065	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HKX69_RS14070	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HKX69_RS14075	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HKX69_RS14095	COG0674	pyruvate-flavodoxin oxidoreductase activity
HKX69_RS14095	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HKX69_RS14100	COG1013	pyruvate-flavodoxin oxidoreductase activity
HKX69_RS14105	COG1733	regulation of RNA biosynthetic process
HKX69_RS14110	COG0702	epimerase
HKX69_RS14140	COG1131	(ABC) transporter
HKX69_RS14155	COG3953	SLT domain
HKX69_RS14155	COG5280	Phage tail tape measure protein TP901
HKX69_RS14160	COG0561	phosphatase activity
HKX69_RS14175	COG0514	ATP-dependent DNA helicase (RecQ)
HKX69_RS14185	COG1007	ATP synthesis coupled electron transport
HKX69_RS14195	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HKX69_RS14200	COG0713	ATP synthesis coupled electron transport
HKX69_RS14210	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HKX69_RS14215	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HKX69_RS14220	COG1034	ATP synthesis coupled electron transport
HKX69_RS14225	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HKX69_RS14235	COG0649	NAD binding
HKX69_RS14240	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HKX69_RS14245	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HKX69_RS14260	COG0242	peptide deformylase activity
HKX69_RS14280	COG2226	methyltransferase
HKX69_RS14300	COG3979	chitinase
HKX69_RS14310	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HKX69_RS14320	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HKX69_RS14345	COG0515	serine threonine protein kinase
HKX69_RS14345	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HKX69_RS14350	COG2226	methyltransferase
HKX69_RS14370	COG0583	DNA-binding transcription factor activity
HKX69_RS14385	COG1309	transcriptional regulator
HKX69_RS14405	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HKX69_RS14415	COG0163	prenyltransferase activity
HKX69_RS14425	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HKX69_RS14445	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HKX69_RS14450	COG1333	cytochrome c biogenesis protein
HKX69_RS14455	COG0785	Cytochrome C biogenesis protein
HKX69_RS14470	COG0406	alpha-ribazole phosphatase activity
HKX69_RS14475	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HKX69_RS14505	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HKX69_RS14520	COG0717	Belongs to the dCTP deaminase family
HKX69_RS14525	COG0297	glycogen (starch) synthase activity
HKX69_RS14530	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HKX69_RS14580	COG2362	D-Aminopeptidase
HKX69_RS14595	COG2205	protein histidine kinase activity
HKX69_RS14605	COG0431	NADPH-dependent FMN reductase
HKX69_RS14610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKX69_RS14615	COG1742	UPF0060 membrane protein
HKX69_RS14640	COG1690	Belongs to the RtcB family
HKX69_RS14660	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HKX69_RS14665	COG0018	arginyl-trna synthetase
HKX69_RS14695	COG0113	porphobilinogen synthase activity
HKX69_RS14705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HKX69_RS14705	COG1648	precorrin-2 dehydrogenase activity
HKX69_RS14710	COG0181	hydroxymethylbilane synthase activity
HKX69_RS14715	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HKX69_RS14720	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HKX69_RS14770	COG0123	including yeast histone deacetylase and acetoin utilization protein
HKX69_RS14775	COG2223	nitrite transmembrane transporter activity
HKX69_RS14785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HKX69_RS14805	COG0180	Tryptophanyl-tRNA synthetase
HKX69_RS14810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HKX69_RS14820	COG1129	ABC transporter
HKX69_RS14820	COG0842	Transport permease protein
HKX69_RS14835	COG4991	sh3 domain protein
HKX69_RS14840	COG0515	serine threonine protein kinase
HKX69_RS14840	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HKX69_RS14845	COG0129	dihydroxy-acid dehydratase activity
HKX69_RS14855	COG1082	Xylose isomerase domain protein TIM barrel
HKX69_RS14860	COG0248	Ppx GppA phosphatase
HKX69_RS14880	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HKX69_RS14895	COG1595	DNA-templated transcription, initiation
HKX69_RS14905	COG0745	RESPONSE REGULATOR receiver
HKX69_RS14910	COG2205	protein histidine kinase activity
HKX69_RS14935	COG0739	heme binding
HKX69_RS14960	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HKX69_RS14980	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HKX69_RS14990	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HKX69_RS14995	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HKX69_RS15020	COG2197	response regulator
HKX69_RS15035	COG0649	NAD binding
HKX69_RS15060	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HKX69_RS15060	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HKX69_RS15075	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HKX69_RS15080	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HKX69_RS15090	COG0302	gtp cyclohydrolase
HKX69_RS15105	COG0037	tRNA processing
HKX69_RS15115	COG2027	D-alanyl-D-alanine carboxypeptidase
HKX69_RS15120	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HKX69_RS15135	COG0789	Transcriptional regulator
HKX69_RS15145	COG0076	glutamate decarboxylase activity
HKX69_RS15165	COG2318	DinB family
HKX69_RS15170	COG1012	belongs to the aldehyde dehydrogenase family
HKX69_RS15225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HKX69_RS15225	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HKX69_RS15230	COG3629	intracellular signal transduction
HKX69_RS15230	COG3903	Transcriptional regulator
HKX69_RS15260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HKX69_RS15265	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HKX69_RS15265	COG1754	DNA topoisomerase type I activity
HKX69_RS15285	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HKX69_RS15290	COG2172	sigma factor antagonist activity
HKX69_RS15295	COG1366	Belongs to the anti-sigma-factor antagonist family
HKX69_RS15300	COG1111	helicase
HKX69_RS15300	COG1205	dead DEAH box helicase
HKX69_RS15365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HKX69_RS15380	COG2267	carboxylic ester hydrolase activity
HKX69_RS15410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HKX69_RS15435	COG0003	Pfam Anion-transporting ATPase
HKX69_RS15445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HKX69_RS15450	COG1610	YqeY-like protein
HKX69_RS15455	COG1408	metallophosphoesterase
HKX69_RS15475	COG1609	Transcriptional regulator
HKX69_RS15570	COG0180	Tryptophanyl-tRNA synthetase
HKX69_RS15575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HKX69_RS15600	COG0494	nUDIX hydrolase
HKX69_RS15625	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HKX69_RS15630	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HKX69_RS15640	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HKX69_RS15680	COG3415	Transposase
HKX69_RS15680	COG2801	Transposase and inactivated derivatives
HKX69_RS15705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HKX69_RS15710	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HKX69_RS15715	COG0640	Transcriptional regulator
HKX69_RS15755	COG0701	Predicted permease
HKX69_RS15805	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HKX69_RS15810	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HKX69_RS15830	COG1802	Transcriptional regulator
HKX69_RS15865	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HKX69_RS15880	COG2197	response regulator
HKX69_RS15885	COG4585	Histidine kinase
HKX69_RS15895	COG3844	kynureninase activity
HKX69_RS15900	COG3483	tryptophan 2,3-dioxygenase activity
HKX69_RS15915	COG0477	Major facilitator Superfamily
HKX69_RS15925	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HKX69_RS15940	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HKX69_RS15970	COG0542	response to heat
HKX69_RS16000	COG4213	ABC transporter substrate-binding protein
HKX69_RS16005	COG0789	Transcriptional regulator
HKX69_RS16010	COG0484	heat shock protein binding
HKX69_RS16015	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HKX69_RS16020	COG0443	Heat shock 70 kDa protein
HKX69_RS16025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HKX69_RS16030	COG0247	lactate metabolic process
HKX69_RS16030	COG2181	nitrate reductase activity
HKX69_RS16060	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HKX69_RS16065	COG0717	Belongs to the dCTP deaminase family
HKX69_RS16075	COG3415	Transposase
HKX69_RS16075	COG2801	Transposase and inactivated derivatives
HKX69_RS16120	COG2801	Transposase and inactivated derivatives
HKX69_RS16120	COG3415	Transposase
HKX69_RS16240	COG1278	Cold shock
HKX69_RS16340	COG1191	sigma factor activity
HKX69_RS16350	COG0531	amino acid
HKX69_RS16355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HKX69_RS16360	COG1959	2 iron, 2 sulfur cluster binding
HKX69_RS16370	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS16380	COG0517	IMP dehydrogenase activity
HKX69_RS16390	COG1278	Cold shock
HKX69_RS16395	COG0513	Belongs to the DEAD box helicase family
HKX69_RS16410	COG1595	DNA-templated transcription, initiation
HKX69_RS16420	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HKX69_RS16440	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HKX69_RS16460	COG0366	Alpha amylase catalytic
HKX69_RS16465	COG0640	Transcriptional regulator
HKX69_RS16470	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HKX69_RS16475	COG1957	nucleoside hydrolase
HKX69_RS16530	COG1289	transmembrane transporter activity
HKX69_RS16540	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HKX69_RS16565	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HKX69_RS16580	COG1741	Belongs to the pirin family
HKX69_RS16590	COG1960	acyl-CoA dehydrogenase activity
HKX69_RS16595	COG1362	aminopeptidase activity
HKX69_RS16645	COG0508	dehydrogenase complex catalyzes the overall conversion of
HKX69_RS16650	COG0022	dehydrogenase e1 component
HKX69_RS16665	COG0515	serine threonine protein kinase
HKX69_RS16670	COG0515	serine threonine protein kinase
HKX69_RS16685	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS16685	COG3321	synthase
HKX69_RS16685	COG0604	alcohol dehydrogenase
HKX69_RS16690	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HKX69_RS16720	COG1522	sequence-specific DNA binding
HKX69_RS16730	COG1250	3-hydroxyacyl-CoA dehydrogenase
HKX69_RS16755	COG3396	Phenylacetate-CoA oxygenase
HKX69_RS16760	COG3460	Phenylacetate-CoA oxygenase
HKX69_RS16765	COG3396	Phenylacetate-CoA oxygenase
HKX69_RS16770	COG2151	metal-sulfur cluster biosynthetic enzyme
HKX69_RS16775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HKX69_RS16795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HKX69_RS16810	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS16810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKX69_RS16810	COG0318	PFAM AMP-dependent synthetase and ligase
HKX69_RS16810	COG0300	oxidoreductase activity
HKX69_RS16810	COG3321	synthase
HKX69_RS16815	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HKX69_RS16815	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HKX69_RS16820	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HKX69_RS16820	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HKX69_RS16830	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HKX69_RS16850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKX69_RS16855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HKX69_RS16860	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS16865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HKX69_RS16885	COG0667	Aldo Keto reductase
HKX69_RS16910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HKX69_RS16930	COG0667	Aldo Keto reductase
HKX69_RS16940	COG1716	ATPase activity
HKX69_RS16945	COG1716	ATPase activity
HKX69_RS16960	COG0768	penicillin binding
HKX69_RS16965	COG0515	serine threonine protein kinase
HKX69_RS16970	COG3764	Sortase (surface protein transpeptidase)
HKX69_RS16975	COG3764	Sortase (surface protein transpeptidase)
HKX69_RS17000	COG0705	Rhomboid family
HKX69_RS17025	COG0515	serine threonine protein kinase
HKX69_RS17055	COG2319	Wd-40 repeat
HKX69_RS17055	COG4249	Peptidase C14 caspase catalytic subunit p20
HKX69_RS17055	COG2319	Wd-40 repeat
HKX69_RS17055	COG4249	Peptidase C14 caspase catalytic subunit p20
HKX69_RS17070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HKX69_RS17075	COG0187	DNA topoisomerase II activity
HKX69_RS17080	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HKX69_RS17085	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HKX69_RS17090	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HKX69_RS17095	COG0592	DNA-directed DNA polymerase activity
HKX69_RS17100	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HKX69_RS17105	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HKX69_RS17110	COG0594	ribonuclease P activity
HKX69_RS17115	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HKX69_RS17120	COG0706	membrane insertase activity
HKX69_RS17130	COG0357	Ribosomal RNA small subunit methyltransferase G
HKX69_RS17135	COG1192	Involved in chromosome partitioning
HKX69_RS17150	COG3118	belongs to the thioredoxin family
HKX69_RS17155	COG0492	ferredoxin-NADP+ reductase activity
HKX69_RS17165	COG1595	DNA-templated transcription, initiation
HKX69_RS17170	COG0515	serine threonine protein kinase
HKX69_RS17170	COG2815	serine threonine protein kinase
HKX69_RS17185	COG0617	tRNA 3'-terminal CCA addition
HKX69_RS17205	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HKX69_RS17230	COG0360	Binds together with S18 to 16S ribosomal RNA
HKX69_RS17235	COG0629	single-stranded DNA binding
HKX69_RS17240	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HKX69_RS17245	COG0359	binds to the 23S rRNA
HKX69_RS17255	COG0305	Participates in initiation and elongation during chromosome replication
HKX69_RS17275	COG2814	Major facilitator Superfamily
HKX69_RS17300	COG0626	cystathionine gamma-synthase activity
HKX69_RS17305	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HKX69_RS17310	COG1950	PFAM Membrane protein of
HKX69_RS17315	COG0662	Cupin 2, conserved barrel domain protein
HKX69_RS17340	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HKX69_RS17355	COG1609	Transcriptional regulator
HKX69_RS17360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HKX69_RS17365	COG1271	oxidase subunit
HKX69_RS17370	COG1294	oxidase, subunit
HKX69_RS17375	COG4988	ABC transporter
HKX69_RS17380	COG0561	phosphatase activity
HKX69_RS17390	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HKX69_RS17430	COG0561	phosphatase activity
HKX69_RS17435	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HKX69_RS17440	COG0077	Prephenate dehydratase
HKX69_RS17445	COG2837	iron assimilation
HKX69_RS17480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKX69_RS17485	COG0006	proline dipeptidase activity
HKX69_RS17505	COG0653	protein targeting
HKX69_RS17520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HKX69_RS17540	COG1595	DNA-templated transcription, initiation
HKX69_RS17545	COG0318	PFAM AMP-dependent synthetase and ligase
HKX69_RS17550	COG0784	Response regulator, receiver
HKX69_RS17595	COG1537	nuclear-transcribed mRNA catabolic process, no-go decay
HKX69_RS17625	COG0745	RESPONSE REGULATOR receiver
HKX69_RS17630	COG2205	protein histidine kinase activity
HKX69_RS17640	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HKX69_RS17645	COG0477	Major facilitator Superfamily
HKX69_RS17660	COG3467	pyridoxamine 5'-phosphate
HKX69_RS17665	COG2353	YceI-like domain
HKX69_RS17670	COG0477	Major facilitator Superfamily
HKX69_RS17685	COG1191	sigma factor activity
HKX69_RS17690	COG1191	sigma factor activity
HKX69_RS17725	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HKX69_RS17740	COG0433	COG0433 Predicted ATPase
HKX69_RS17775	COG2372	response to copper ion
HKX69_RS17775	COG1276	copper resistance
HKX69_RS17790	COG1902	pentaerythritol trinitrate reductase activity
HKX69_RS17820	COG0151	Belongs to the GarS family
HKX69_RS17835	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HKX69_RS17845	COG2197	response regulator
HKX69_RS17880	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HKX69_RS17885	COG0047	phosphoribosylformylglycinamidine synthase activity
HKX69_RS17890	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HKX69_RS17915	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HKX69_RS17950	COG1643	Atp-dependent helicase
HKX69_RS17995	COG0513	Belongs to the DEAD box helicase family
HKX69_RS18020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HKX69_RS18030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HKX69_RS18030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HKX69_RS18050	COG0667	Aldo Keto reductase
HKX69_RS18060	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HKX69_RS18065	COG0579	oxidoreductase
HKX69_RS18095	COG1252	NADH dehydrogenase
HKX69_RS18175	COG0671	phosphoesterase, PA-phosphatase related
HKX69_RS18180	COG0277	FAD linked oxidase domain protein
HKX69_RS18200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HKX69_RS18205	COG0306	phosphate transporter
HKX69_RS18215	COG1937	Protein conserved in bacteria
HKX69_RS18245	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HKX69_RS18255	COG1131	(ABC) transporter
HKX69_RS18260	COG1725	Transcriptional regulator
HKX69_RS18265	COG0456	acetyltransferase
HKX69_RS18270	COG0737	Belongs to the 5'-nucleotidase family
HKX69_RS18280	COG1846	Transcriptional regulator
HKX69_RS18290	COG0745	RESPONSE REGULATOR receiver
HKX69_RS18300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HKX69_RS18305	COG1609	Transcriptional regulator
HKX69_RS18310	COG0745	RESPONSE REGULATOR receiver
HKX69_RS18335	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HKX69_RS18350	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HKX69_RS18360	COG3485	protocatechuate 3,4-dioxygenase
HKX69_RS18380	COG2897	thiosulfate sulfurtransferase activity
HKX69_RS18410	COG1490	D-aminoacyl-tRNA deacylase activity
HKX69_RS18420	COG2188	Transcriptional regulator
HKX69_RS18430	COG2186	Transcriptional regulator
HKX69_RS18435	COG0546	phosphoglycolate phosphatase activity
HKX69_RS18440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKX69_RS18450	COG1309	transcriptional regulator
HKX69_RS18455	COG3973	AAA domain
HKX69_RS18465	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HKX69_RS18500	COG0438	transferase activity, transferring glycosyl groups
HKX69_RS18545	COG0588	phosphoglycerate mutase activity
HKX69_RS18570	COG5002	protein histidine kinase activity
HKX69_RS18585	COG1329	Transcriptional regulator
HKX69_RS18590	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HKX69_RS18595	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HKX69_RS18605	COG0215	cysteine-tRNA ligase activity
HKX69_RS18615	COG3415	Transposase
HKX69_RS18615	COG2801	Transposase and inactivated derivatives
HKX69_RS18625	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HKX69_RS18635	COG3842	ATPase activity
HKX69_RS18695	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HKX69_RS18715	COG3300	MHYT domain
HKX69_RS18715	COG5001	Diguanylate cyclase
HKX69_RS18725	COG1105	Belongs to the carbohydrate kinase PfkB family
HKX69_RS18740	COG1653	transport
HKX69_RS18760	COG0463	Glycosyl transferase, family 2
HKX69_RS18775	COG1278	Cold shock
HKX69_RS18780	COG0459	protein refolding
HKX69_RS18795	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HKX69_RS18800	COG1737	Transcriptional regulator
HKX69_RS18815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HKX69_RS18835	COG3973	AAA domain
HKX69_RS18855	COG1231	oxidoreductase activity
HKX69_RS18860	COG1061	Type III restriction enzyme res subunit
HKX69_RS18895	COG1278	Cold shock
HKX69_RS18900	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HKX69_RS18905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HKX69_RS18915	COG2814	Major facilitator Superfamily
HKX69_RS18945	COG2326	polyphosphate kinase activity
HKX69_RS18975	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HKX69_RS18985	COG2252	PERMEase
HKX69_RS18995	COG1846	Transcriptional regulator
HKX69_RS19015	COG0667	Aldo Keto reductase
HKX69_RS19035	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HKX69_RS19060	COG5006	permease, DMT superfamily
HKX69_RS19080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HKX69_RS19095	COG0318	PFAM AMP-dependent synthetase and ligase
HKX69_RS19105	COG1309	transcriptional regulator
HKX69_RS19120	COG0259	pyridoxamine-phosphate oxidase activity
HKX69_RS19135	COG4821	SIS domain
HKX69_RS19145	COG0596	Alpha beta hydrolase
HKX69_RS19145	COG2945	thiolester hydrolase activity
HKX69_RS19190	COG1366	Belongs to the anti-sigma-factor antagonist family
HKX69_RS19220	COG2072	flavoprotein involved in K transport
HKX69_RS19225	COG0259	pyridoxamine-phosphate oxidase activity
HKX69_RS19230	COG1280	lysine exporter protein (LysE YggA)
HKX69_RS19235	COG1522	sequence-specific DNA binding
HKX69_RS19240	COG1309	transcriptional regulator
HKX69_RS19250	COG0515	serine threonine protein kinase
HKX69_RS19250	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HKX69_RS19300	COG3629	intracellular signal transduction
HKX69_RS19300	COG3903	Transcriptional regulator
HKX69_RS19320	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HKX69_RS19350	COG1686	Belongs to the peptidase S11 family
HKX69_RS19370	COG0386	Belongs to the glutathione peroxidase family
HKX69_RS19415	COG1414	Transcriptional regulator
HKX69_RS19435	COG1846	Transcriptional regulator
HKX69_RS19440	COG3384	dioxygenase
HKX69_RS19445	COG1247	-acetyltransferase
HKX69_RS19465	COG0477	Major facilitator Superfamily
HKX69_RS19470	COG1349	DNA-binding transcription factor activity
HKX69_RS19475	COG1105	Belongs to the carbohydrate kinase PfkB family
HKX69_RS19480	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKX69_RS19480	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKX69_RS19480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKX69_RS19500	COG3191	aminopeptidase activity
HKX69_RS19515	COG1970	mechanosensitive ion channel activity
HKX69_RS19525	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HKX69_RS19535	COG0477	Major facilitator Superfamily
HKX69_RS19550	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HKX69_RS19555	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HKX69_RS19565	COG0315	cyclic pyranopterin monophosphate synthase activity
HKX69_RS19570	COG0521	Mo-molybdopterin cofactor biosynthetic process
HKX69_RS19570	COG0315	cyclic pyranopterin monophosphate synthase activity
HKX69_RS19575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HKX69_RS19595	COG0708	Exodeoxyribonuclease III
HKX69_RS19600	COG0789	Transcriptional regulator
HKX69_RS19605	COG2072	flavoprotein involved in K transport
HKX69_RS19610	COG2267	carboxylic ester hydrolase activity
HKX69_RS19615	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS19625	COG0793	Belongs to the peptidase S41A family
HKX69_RS19625	COG4946	Tricorn protease homolog
HKX69_RS19635	COG2409	Drug exporters of the RND superfamily
HKX69_RS19640	COG0442	prolyl-tRNA aminoacylation
HKX69_RS19660	COG1122	ATPase activity
HKX69_RS19670	COG0310	cobalt ion transport
HKX69_RS19705	COG0084	hydrolase, TatD family'
HKX69_RS19710	COG3584	3D domain protein
HKX69_RS19710	COG3583	domain protein
HKX69_RS19715	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HKX69_RS19720	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HKX69_RS19730	COG0488	(ABC) transporter
HKX69_RS19770	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HKX69_RS19785	COG2197	response regulator
HKX69_RS19795	COG4106	trans-aconitate 2-methyltransferase activity
HKX69_RS19800	COG1309	transcriptional regulator
HKX69_RS19810	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HKX69_RS19820	COG0193	aminoacyl-tRNA hydrolase activity
HKX69_RS19825	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HKX69_RS19830	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HKX69_RS19835	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HKX69_RS19880	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HKX69_RS19890	COG0477	Major facilitator Superfamily
HKX69_RS19895	COG1136	(ABC) transporter
HKX69_RS19900	COG1136	(ABC) transporter
HKX69_RS19900	COG0577	efflux transmembrane transporter activity
HKX69_RS19975	COG0148	phosphopyruvate hydratase activity
HKX69_RS20005	COG1252	NADH dehydrogenase
HKX69_RS20010	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HKX69_RS20015	COG0577	efflux transmembrane transporter activity
HKX69_RS20020	COG1136	(ABC) transporter
HKX69_RS20020	COG0577	efflux transmembrane transporter activity
HKX69_RS20030	COG0582	viral genome integration into host DNA
HKX69_RS20120	COG0183	Belongs to the thiolase family
HKX69_RS20125	COG2755	lipolytic protein G-D-S-L family
HKX69_RS20140	COG4221	oxidoreductase activity
HKX69_RS20185	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HKX69_RS20200	COG1228	amidohydrolase
HKX69_RS20220	COG1191	sigma factor activity
HKX69_RS20225	COG1366	Belongs to the anti-sigma-factor antagonist family
HKX69_RS20240	COG3104	oligopeptide transport
HKX69_RS20245	COG0745	RESPONSE REGULATOR receiver
HKX69_RS20250	COG2205	protein histidine kinase activity
HKX69_RS20265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HKX69_RS20290	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HKX69_RS20305	COG1316	TRANSCRIPTIONal
HKX69_RS20315	COG1316	TRANSCRIPTIONal
HKX69_RS20325	COG2826	transposase and inactivated derivatives, IS30 family
HKX69_RS20330	COG1316	TRANSCRIPTIONal
HKX69_RS20365	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HKX69_RS20365	COG0778	Nitroreductase
HKX69_RS20370	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HKX69_RS20410	COG2835	tetraacyldisaccharide 4'-kinase activity
HKX69_RS20420	COG1482	cell wall glycoprotein biosynthetic process
HKX69_RS20430	COG0681	Belongs to the peptidase S26 family
HKX69_RS20435	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HKX69_RS20475	COG0714	Associated with various cellular activities
HKX69_RS20495	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HKX69_RS20500	COG0745	RESPONSE REGULATOR receiver
HKX69_RS20505	COG5000	phosphorelay sensor kinase activity
HKX69_RS20505	COG5002	protein histidine kinase activity
HKX69_RS20510	COG0823	Involved in the tonB-independent uptake of proteins
HKX69_RS20520	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HKX69_RS20525	COG2197	response regulator
HKX69_RS20530	COG3214	Protein conserved in bacteria
HKX69_RS20540	COG0653	protein targeting
HKX69_RS20565	COG2902	Dehydrogenase
HKX69_RS20575	COG1215	transferase activity, transferring glycosyl groups
HKX69_RS20580	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HKX69_RS20585	COG1134	teichoic acid transport
HKX69_RS20600	COG1215	transferase activity, transferring glycosyl groups
HKX69_RS20615	COG1846	Transcriptional regulator
HKX69_RS20620	COG1764	response to oxidative stress
HKX69_RS20625	COG0463	Glycosyl transferase, family 2
HKX69_RS20625	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HKX69_RS20630	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HKX69_RS20635	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HKX69_RS20640	COG0395	ABC-type sugar transport system, permease component
HKX69_RS20660	COG0515	serine threonine protein kinase
HKX69_RS20665	COG0515	serine threonine protein kinase
HKX69_RS20670	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HKX69_RS20685	COG2884	Cell division ATP-binding protein ftsE
HKX69_RS20690	COG2177	Part of the ABC transporter FtsEX involved in
HKX69_RS20695	COG0793	Belongs to the peptidase S41A family
HKX69_RS20700	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HKX69_RS20715	COG0583	DNA-binding transcription factor activity
HKX69_RS20755	COG2223	nitrite transmembrane transporter activity
HKX69_RS20775	COG3973	AAA domain
HKX69_RS20785	COG0776	regulation of translation
HKX69_RS20790	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HKX69_RS20795	COG1678	Uncharacterized ACR, COG1678
HKX69_RS20805	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HKX69_RS20820	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HKX69_RS20880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HKX69_RS20895	COG4948	Mandelate Racemase Muconate Lactonizing
HKX69_RS20910	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HKX69_RS20920	COG0277	FAD linked oxidase domain protein
HKX69_RS20955	COG1335	isochorismatase
HKX69_RS20965	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HKX69_RS20975	COG1113	amino acid transport
HKX69_RS21010	COG1263	PTS System
HKX69_RS21015	COG1263	PTS System
HKX69_RS21020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKX69_RS21025	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HKX69_RS21040	COG4555	ABC transporter
HKX69_RS21055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HKX69_RS21060	COG2076	Multidrug Resistance protein
HKX69_RS21085	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HKX69_RS21095	COG2733	membrane
HKX69_RS21100	COG2271	Major facilitator Superfamily
HKX69_RS21120	COG0071	Belongs to the small heat shock protein (HSP20) family
HKX69_RS21180	COG0701	Predicted permease
HKX69_RS21220	COG4702	Belongs to the UPF0303 family
HKX69_RS21225	COG0673	inositol 2-dehydrogenase activity
HKX69_RS21230	COG1940	carbohydrate kinase activity
HKX69_RS21255	COG2186	Transcriptional regulator
HKX69_RS21275	COG3397	chitin binding
HKX69_RS21295	COG1126	abc transporter atp-binding protein
HKX69_RS21300	COG0765	amino acid transport
HKX69_RS21305	COG0765	amino acid transport
HKX69_RS21310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKX69_RS21315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKX69_RS21350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKX69_RS21375	COG0406	alpha-ribazole phosphatase activity
HKX69_RS21400	COG0745	RESPONSE REGULATOR receiver
HKX69_RS21410	COG3979	chitinase
HKX69_RS21435	COG0395	ABC-type sugar transport system, permease component
HKX69_RS21455	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HKX69_RS21460	COG4977	sequence-specific DNA binding
HKX69_RS21470	COG0589	response to stress
HKX69_RS21480	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HKX69_RS21515	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HKX69_RS21535	COG1960	acyl-CoA dehydrogenase activity
HKX69_RS21550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HKX69_RS21555	COG1309	transcriptional regulator
HKX69_RS21570	COG1946	Acyl-CoA thioesterase
HKX69_RS21590	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HKX69_RS21600	COG0028	Belongs to the TPP enzyme family
HKX69_RS21620	COG1132	(ABC) transporter
HKX69_RS21645	COG3415	Transposase
HKX69_RS21645	COG2801	Transposase and inactivated derivatives
HKX69_RS21650	COG1472	Belongs to the glycosyl hydrolase 3 family
HKX69_RS21675	COG1846	Transcriptional regulator
HKX69_RS21675	COG0456	acetyltransferase
HKX69_RS21685	COG1609	Transcriptional regulator
HKX69_RS21690	COG0673	inositol 2-dehydrogenase activity
HKX69_RS21705	COG1869	D-ribose catabolic process
HKX69_RS21710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKX69_RS21720	COG1129	ABC transporter
HKX69_RS21745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HKX69_RS21820	COG1063	alcohol dehydrogenase
HKX69_RS21830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKX69_RS21840	COG3718	enzyme involved in inositol metabolism
HKX69_RS21845	COG3962	Belongs to the TPP enzyme family
HKX69_RS21865	COG1131	(ABC) transporter
HKX69_RS21915	COG0438	transferase activity, transferring glycosyl groups
HKX69_RS21935	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HKX69_RS21980	COG2304	oxidoreductase activity
HKX69_RS21995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKX69_RS22010	COG0702	epimerase
HKX69_RS22015	COG1733	regulation of RNA biosynthetic process
HKX69_RS22160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HKX69_RS22165	COG0629	single-stranded DNA binding
HKX69_RS22200	COG1136	(ABC) transporter
HKX69_RS22220	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HKX69_RS22250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKX69_RS22260	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HKX69_RS22270	COG1486	melibiose metabolic process
HKX69_RS22275	COG0395	ABC-type sugar transport system, permease component
HKX69_RS22280	COG1175	transmembrane transport
HKX69_RS22285	COG1653	transport
HKX69_RS22290	COG1940	carbohydrate kinase activity
HKX69_RS22310	COG0668	transmembrane transport
HKX69_RS22330	COG1131	(ABC) transporter
HKX69_RS22340	COG1595	DNA-templated transcription, initiation
HKX69_RS22370	COG1846	Transcriptional regulator
HKX69_RS22375	COG0697	spore germination
HKX69_RS22470	COG2755	lipolytic protein G-D-S-L family
HKX69_RS22485	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HKX69_RS22490	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HKX69_RS22495	COG1113	amino acid transport
HKX69_RS22505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKX69_RS22510	COG1116	anion transmembrane transporter activity
HKX69_RS22515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKX69_RS22525	COG1940	carbohydrate kinase activity
HKX69_RS22535	COG1113	amino acid transport
HKX69_RS22550	COG4552	Acetyltransferase involved in intracellular survival and related
HKX69_RS22565	COG3594	Acyltransferase
HKX69_RS22585	COG0544	peptidyl-prolyl cis-trans isomerase activity
HKX69_RS22590	COG0740	serine-type endopeptidase activity
HKX69_RS22595	COG0740	serine-type endopeptidase activity
HKX69_RS22600	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HKX69_RS22610	COG0525	valine-tRNA ligase activity
HKX69_RS22615	COG0285	dihydrofolate synthase activity
HKX69_RS22625	COG0105	UTP biosynthetic process
HKX69_RS22630	COG1077	Cell shape determining protein MreB Mrl
HKX69_RS22645	COG0768	penicillin binding
HKX69_RS22650	COG0772	Belongs to the SEDS family
HKX69_RS22680	COG1530	ribonuclease E activity
HKX69_RS22690	COG0371	Dehydrogenase
HKX69_RS22695	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HKX69_RS22700	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HKX69_RS22705	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HKX69_RS22715	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HKX69_RS22720	COG1216	Glycosyl transferase, family 2
HKX69_RS22735	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HKX69_RS22745	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HKX69_RS22760	COG0501	Belongs to the peptidase M48B family
HKX69_RS22775	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HKX69_RS22790	COG0588	phosphoglycerate mutase activity
HKX69_RS22805	COG0477	Major facilitator Superfamily
HKX69_RS22820	COG1051	belongs to the nudix hydrolase family
HKX69_RS22830	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HKX69_RS22840	COG0495	leucyl-tRNA aminoacylation
HKX69_RS22850	COG1307	EDD domain protein, DegV family
HKX69_RS22855	COG1596	polysaccharide export
HKX69_RS22855	COG1555	photosystem II stabilization
HKX69_RS22905	COG0268	Binds directly to 16S ribosomal RNA
HKX69_RS22910	COG0481	GTPase activity
HKX69_RS22940	COG1420	regulation of RNA biosynthetic process
HKX69_RS22945	COG0484	heat shock protein binding
HKX69_RS22950	COG2070	2-Nitropropane dioxygenase
HKX69_RS22970	COG4946	Tricorn protease homolog
HKX69_RS22970	COG0793	Belongs to the peptidase S41A family
HKX69_RS22975	COG0537	adenosine 5'-monophosphoramidase activity
HKX69_RS22980	COG1234	tRNA 3'-trailer cleavage
HKX69_RS22985	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HKX69_RS22995	COG4948	Mandelate Racemase Muconate Lactonizing
HKX69_RS23000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKX69_RS23010	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HKX69_RS23020	COG2315	Protein conserved in bacteria
HKX69_RS23040	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HKX69_RS23070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HKX69_RS23085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKX69_RS23090	COG4608	Belongs to the ABC transporter superfamily
HKX69_RS23095	COG0444	Belongs to the ABC transporter superfamily
HKX69_RS23105	COG0747	negative chemotaxis
HKX69_RS23110	COG1381	Involved in DNA repair and RecF pathway recombination
HKX69_RS23115	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HKX69_RS23130	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HKX69_RS23135	COG1121	(ABC) transporter
HKX69_RS23145	COG0423	glycine-tRNA ligase activity
HKX69_RS23155	COG0667	Aldo Keto reductase
HKX69_RS23165	COG0477	Major facilitator Superfamily
HKX69_RS23215	COG1940	carbohydrate kinase activity
HKX69_RS23215	COG1846	Transcriptional regulator
HKX69_RS23220	COG0574	Belongs to the PEP-utilizing enzyme family
HKX69_RS23220	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HKX69_RS23225	COG2182	Extracellular solute-binding protein
HKX69_RS23230	COG1175	transmembrane transport
HKX69_RS23235	COG0395	ABC-type sugar transport system, permease component
HKX69_RS23240	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS23245	COG1309	transcriptional regulator
HKX69_RS23250	COG2130	NADP-dependent
HKX69_RS23260	COG2146	nitrite reductase [NAD(P)H] activity
HKX69_RS23260	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HKX69_RS23265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HKX69_RS23305	COG0243	molybdopterin cofactor binding
HKX69_RS23310	COG2949	membrane
HKX69_RS23320	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HKX69_RS23330	COG0358	DNA primase activity
HKX69_RS23335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HKX69_RS23350	COG1070	Carbohydrate kinase
HKX69_RS23375	COG2226	methyltransferase
HKX69_RS23385	COG2188	Transcriptional regulator
HKX69_RS23420	COG1077	Cell shape determining protein MreB Mrl
HKX69_RS23445	COG1404	Belongs to the peptidase S8 family
HKX69_RS23450	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HKX69_RS23450	COG0825	malonyl-CoA metabolic process
HKX69_RS23455	COG0318	PFAM AMP-dependent synthetase and ligase
HKX69_RS23480	COG1414	Transcriptional regulator
HKX69_RS23485	COG3386	PFAM SMP-30 Gluconolaconase
HKX69_RS23520	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HKX69_RS23530	COG4214	carbohydrate transport
HKX69_RS23570	COG1764	response to oxidative stress
HKX69_RS23575	COG2130	NADP-dependent
HKX69_RS23615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HKX69_RS23620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKX69_RS23625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HKX69_RS23640	COG1741	Belongs to the pirin family
HKX69_RS23655	COG0789	Transcriptional regulator
HKX69_RS23670	COG1309	transcriptional regulator
HKX69_RS23675	COG0477	Major facilitator Superfamily
HKX69_RS23685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HKX69_RS23690	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HKX69_RS23735	COG1358	cellular component organization or biogenesis
HKX69_RS23750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HKX69_RS23820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HKX69_RS23860	COG4122	O-methyltransferase activity
HKX69_RS23865	COG0477	Major facilitator Superfamily
HKX69_RS23875	COG3619	membrane
HKX69_RS23895	COG3845	ABC transporter
HKX69_RS23910	COG1657	PFAM Prenyltransferase squalene oxidase
HKX69_RS23950	COG1309	transcriptional regulator
HKX69_RS23955	COG0438	transferase activity, transferring glycosyl groups
HKX69_RS23985	COG2247	cell wall binding repeat
HKX69_RS23985	COG0860	N-Acetylmuramoyl-L-alanine amidase
HKX69_RS23995	COG0477	Major facilitator Superfamily
HKX69_RS24010	COG2197	response regulator
HKX69_RS24025	COG4585	Histidine kinase
HKX69_RS24030	COG2030	dehydratase
HKX69_RS24045	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HKX69_RS24060	COG0800	Aldolase
HKX69_RS24065	COG3022	response to hydroperoxide
HKX69_RS24070	COG0557	exoribonuclease II activity
HKX69_RS24090	COG2259	Doxx family
HKX69_RS24095	COG0667	Aldo Keto reductase
HKX69_RS24110	COG0673	inositol 2-dehydrogenase activity
HKX69_RS24115	COG2814	Major facilitator Superfamily
HKX69_RS24120	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HKX69_RS24145	COG0672	)-iron permease
HKX69_RS24150	COG2837	iron assimilation
HKX69_RS24205	COG1994	Peptidase M50
HKX69_RS24230	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HKX69_RS24235	COG0477	Major facilitator Superfamily
HKX69_RS24250	COG2814	Major facilitator Superfamily
HKX69_RS24295	COG1959	2 iron, 2 sulfur cluster binding
HKX69_RS24305	COG0174	glutamine synthetase
HKX69_RS24315	COG1982	Orn Lys Arg decarboxylase major
HKX69_RS24330	COG3511	phospholipase C
HKX69_RS24340	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HKX69_RS24350	COG1609	Transcriptional regulator
HKX69_RS24360	COG1175	transmembrane transport
HKX69_RS24365	COG3833	ABC-type maltose transport systems, permease component
HKX69_RS24370	COG0366	Alpha amylase catalytic
HKX69_RS24410	COG1309	transcriptional regulator
HKX69_RS24435	COG2197	response regulator
HKX69_RS24450	COG0745	RESPONSE REGULATOR receiver
HKX69_RS24465	COG2267	carboxylic ester hydrolase activity
HKX69_RS24500	COG0501	Belongs to the peptidase M48B family
HKX69_RS24515	COG0174	glutamine synthetase
HKX69_RS24535	COG0662	Cupin 2, conserved barrel domain protein
HKX69_RS24545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HKX69_RS24550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKX69_RS24555	COG2867	negative regulation of translational initiation
HKX69_RS24585	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HKX69_RS24590	COG0321	lipoyl(octanoyl) transferase activity
HKX69_RS24630	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HKX69_RS24640	COG0508	dehydrogenase complex catalyzes the overall conversion of
HKX69_RS24645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKX69_RS24650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HKX69_RS24655	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HKX69_RS24670	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HKX69_RS24670	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HKX69_RS24675	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HKX69_RS24695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HKX69_RS24725	COG2197	response regulator
HKX69_RS24730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKX69_RS24735	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HKX69_RS24755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKX69_RS24765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HKX69_RS24770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HKX69_RS24780	COG1376	ErfK ybiS ycfS ynhG family protein
HKX69_RS24790	COG1845	cytochrome c oxidase, subunit III
HKX69_RS24795	COG2010	Cytochrome c
HKX69_RS24800	COG0723	plastoquinol--plastocyanin reductase activity
HKX69_RS24805	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HKX69_RS24810	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HKX69_RS24815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HKX69_RS24885	COG0003	Pfam Anion-transporting ATPase
HKX69_RS24895	COG1940	carbohydrate kinase activity
HKX69_RS24920	COG4585	Histidine kinase
HKX69_RS24930	COG0205	6-phosphofructokinase activity
HKX69_RS24945	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HKX69_RS24955	COG2193	ferroxidase activity
HKX69_RS24960	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HKX69_RS24970	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HKX69_RS24975	COG2815	serine threonine protein kinase
HKX69_RS24975	COG0515	serine threonine protein kinase
HKX69_RS24980	COG2022	thiamine diphosphate biosynthetic process
HKX69_RS24990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKX69_RS24990	COG2022	thiamine diphosphate biosynthetic process
HKX69_RS25010	COG0352	thiamine-phosphate diphosphorylase activity
HKX69_RS25035	COG1309	transcriptional regulator
HKX69_RS25040	COG1511	domain protein
HKX69_RS25045	COG1121	(ABC) transporter
HKX69_RS25055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HKX69_RS25075	COG0714	Associated with various cellular activities
HKX69_RS25085	COG0275	rRNA processing
HKX69_RS25095	COG0768	penicillin binding
HKX69_RS25100	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HKX69_RS25110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HKX69_RS25115	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HKX69_RS25125	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HKX69_RS25135	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HKX69_RS25150	COG1799	cell septum assembly
HKX69_RS25160	COG3599	regulation of cell shape
HKX69_RS25165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HKX69_RS25175	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HKX69_RS25230	COG0587	DNA-directed DNA polymerase activity
HKX69_RS25240	COG1432	Conserved Protein
HKX69_RS25260	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HKX69_RS25280	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HKX69_RS25285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HKX69_RS25290	COG0131	Imidazoleglycerol-phosphate dehydratase
HKX69_RS25300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HKX69_RS25305	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HKX69_RS25310	COG0251	oxidation-reduction process
HKX69_RS25315	COG0107	imidazoleglycerol-phosphate synthase activity
HKX69_RS25330	COG0346	lactoylglutathione lyase activity
HKX69_RS25340	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HKX69_RS25365	COG0134	indole-3-glycerol-phosphate synthase activity
HKX69_RS25375	COG0133	tryptophan synthase activity
HKX69_RS25380	COG0159	tryptophan synthase activity
HKX69_RS25390	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HKX69_RS25395	COG2301	Belongs to the HpcH HpaI aldolase family
HKX69_RS25400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HKX69_RS25405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKX69_RS25425	COG1397	ADP-ribosylglycohydrolase
HKX69_RS25435	COG0069	glutamate synthase activity
HKX69_RS25435	COG0067	glutamate synthase
HKX69_RS25435	COG0070	glutamate synthase
HKX69_RS25445	COG2304	oxidoreductase activity
HKX69_RS25455	COG0477	Major facilitator Superfamily
HKX69_RS25465	COG0287	Prephenate dehydrogenase
HKX69_RS25465	COG1605	Chorismate mutase
HKX69_RS25485	COG0737	Belongs to the 5'-nucleotidase family
HKX69_RS25515	COG0411	ABC transporter
HKX69_RS25545	COG2050	protein possibly involved in aromatic compounds catabolism
HKX69_RS25575	COG1643	Atp-dependent helicase
HKX69_RS25580	COG2226	methyltransferase
HKX69_RS25585	COG0539	negative regulation of cytoplasmic translation
HKX69_RS25600	COG0237	dephospho-CoA kinase activity
HKX69_RS25620	COG2226	methyltransferase
HKX69_RS25670	COG1132	(ABC) transporter
HKX69_RS25700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKX69_RS25705	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HKX69_RS25725	COG2910	NAD(P)H-binding
HKX69_RS25740	COG0598	Magnesium transport protein CorA
HKX69_RS25745	COG2226	methyltransferase
HKX69_RS25755	COG2313	pseudouridylate synthase activity
HKX69_RS25765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HKX69_RS25770	COG0584	glycerophosphoryl diester phosphodiesterase
HKX69_RS25780	COG0556	nucleotide-excision repair
HKX69_RS25800	COG0387	Pfam Sodium calcium exchanger
HKX69_RS25805	COG0477	Major facilitator Superfamily
HKX69_RS25810	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HKX69_RS25820	COG0765	amino acid transport
HKX69_RS25825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKX69_RS25840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HKX69_RS25865	COG0322	excinuclease ABC activity
HKX69_RS25870	COG1660	Displays ATPase and GTPase activities
HKX69_RS25875	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HKX69_RS25880	COG1481	regulation of sporulation
HKX69_RS25890	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HKX69_RS25895	COG0126	phosphoglycerate kinase activity
HKX69_RS25900	COG0149	triose-phosphate isomerase activity
HKX69_RS25905	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HKX69_RS25920	COG0166	Belongs to the GPI family
HKX69_RS25935	COG1136	(ABC) transporter
HKX69_RS25940	COG1695	Transcriptional regulator
HKX69_RS25945	COG1653	transport
HKX69_RS25950	COG0366	Alpha amylase catalytic
HKX69_RS25960	COG1175	transmembrane transport
HKX69_RS25965	COG0395	ABC-type sugar transport system, permease component
HKX69_RS25975	COG0363	glucosamine-6-phosphate deaminase activity
HKX69_RS25990	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HKX69_RS26000	COG0109	protoheme IX farnesyltransferase activity
HKX69_RS26020	COG1612	heme a metabolic process
HKX69_RS26030	COG1131	(ABC) transporter
HKX69_RS26035	COG2746	aminoglycoside 3-N-acetyltransferase activity
HKX69_RS26050	COG0719	Fe-S assembly protein
HKX69_RS26060	COG0396	ATPase activity
HKX69_RS26065	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HKX69_RS26070	COG0822	iron-sulfur transferase activity
HKX69_RS26075	COG2151	metal-sulfur cluster biosynthetic enzyme
HKX69_RS26085	COG2076	Multidrug Resistance protein
HKX69_RS26090	COG3226	Transcriptional regulator
HKX69_RS26095	COG2171	N-acyltransferase activity
HKX69_RS26115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKX69_RS26155	COG1309	transcriptional regulator
HKX69_RS26165	COG1063	alcohol dehydrogenase
HKX69_RS26170	COG0395	ABC-type sugar transport system, permease component
HKX69_RS26185	COG1349	DNA-binding transcription factor activity
HKX69_RS26190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HKX69_RS26195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKX69_RS26230	COG1802	Transcriptional regulator
HKX69_RS26235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKX69_RS26260	COG2252	PERMEase
HKX69_RS26275	COG1414	Transcriptional regulator
HKX69_RS26300	COG5285	phytanoyl-CoA dioxygenase
HKX69_RS26305	COG1917	Cupin 2, conserved barrel domain protein
HKX69_RS26310	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HKX69_RS26315	COG0456	acetyltransferase
HKX69_RS26320	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HKX69_RS26325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKX69_RS26330	COG0765	amino acid transport
HKX69_RS26355	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HKX69_RS26390	COG1797	cobyrinic acid a,c-diamide synthase activity
HKX69_RS26410	COG1492	cobalamin metabolic process
HKX69_RS26435	COG0235	Class ii aldolase
HKX69_RS26460	COG0488	(ABC) transporter
HKX69_RS26510	COG3387	PFAM Glycoside hydrolase 15-related
HKX69_RS26525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HKX69_RS26540	COG1063	alcohol dehydrogenase
HKX69_RS26545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HKX69_RS26550	COG1404	Belongs to the peptidase S8 family
HKX69_RS26565	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HKX69_RS26570	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HKX69_RS26590	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HKX69_RS26615	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS26630	COG2186	Transcriptional regulator
HKX69_RS26650	COG0560	Phosphoserine phosphatase
HKX69_RS26650	COG3830	Belongs to the UPF0237 family
HKX69_RS26655	COG1716	ATPase activity
HKX69_RS26655	COG0842	Transport permease protein
HKX69_RS26655	COG1131	(ABC) transporter
HKX69_RS26675	COG3850	Histidine kinase
HKX69_RS26680	COG2197	response regulator
HKX69_RS26695	COG1119	ATPase activity
HKX69_RS26715	COG1881	PFAM PEBP family protein
HKX69_RS26725	COG2094	Belongs to the DNA glycosylase MPG family
HKX69_RS26755	COG0647	UMP catabolic process
HKX69_RS26760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKX69_RS26765	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKX69_RS26770	COG1120	ATPase activity
HKX69_RS26790	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HKX69_RS26795	COG0497	DNA recombination
HKX69_RS26800	COG0297	glycogen (starch) synthase activity
HKX69_RS26815	COG3387	PFAM Glycoside hydrolase 15-related
HKX69_RS26820	COG0504	CTP synthase activity
HKX69_RS26835	COG0686	Belongs to the AlaDH PNT family
HKX69_RS26850	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HKX69_RS26855	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HKX69_RS26860	COG1187	pseudouridine synthase activity
HKX69_RS26865	COG1397	ADP-ribosylglycohydrolase
HKX69_RS26870	COG3541	Predicted nucleotidyltransferase
HKX69_RS26895	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HKX69_RS26905	COG1160	GTP binding
HKX69_RS26920	COG3583	domain protein
HKX69_RS26930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HKX69_RS26940	COG0671	phosphoesterase, PA-phosphatase related
HKX69_RS26950	COG0477	Major facilitator Superfamily
HKX69_RS26955	COG1960	acyl-CoA dehydrogenase activity
HKX69_RS26960	COG1799	cell septum assembly
HKX69_RS26995	COG0765	amino acid transport
HKX69_RS27005	COG1126	abc transporter atp-binding protein
HKX69_RS27020	COG0587	DNA-directed DNA polymerase activity
HKX69_RS27035	COG2264	protein methyltransferase activity
HKX69_RS27050	COG1725	Transcriptional regulator
HKX69_RS27065	COG2755	lipolytic protein G-D-S-L family
HKX69_RS27085	COG1595	DNA-templated transcription, initiation
HKX69_RS27100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HKX69_RS27115	COG2188	Transcriptional regulator
HKX69_RS27120	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HKX69_RS27130	COG1309	transcriptional regulator
HKX69_RS27135	COG0243	molybdopterin cofactor binding
HKX69_RS27140	COG2851	Citrate transporter
HKX69_RS27180	COG1960	acyl-CoA dehydrogenase activity
HKX69_RS27200	COG0789	Transcriptional regulator
HKX69_RS27245	COG3876	Protein conserved in bacteria
HKX69_RS27255	COG0318	PFAM AMP-dependent synthetase and ligase
HKX69_RS27285	COG2149	membrane
HKX69_RS27290	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HKX69_RS27315	COG1063	alcohol dehydrogenase
HKX69_RS27320	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS27330	COG3265	gluconokinase activity
HKX69_RS27335	COG2186	Transcriptional regulator
HKX69_RS27340	COG3012	SEC-C Motif Domain Protein
HKX69_RS27360	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HKX69_RS27360	COG1796	DNA polymerase
HKX69_RS27370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HKX69_RS27400	COG0667	Aldo Keto reductase
HKX69_RS27405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKX69_RS27415	COG0598	Magnesium transport protein CorA
HKX69_RS27435	COG0215	cysteine-tRNA ligase activity
HKX69_RS27445	COG2186	Transcriptional regulator
HKX69_RS27450	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HKX69_RS27455	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HKX69_RS27460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HKX69_RS27465	COG1414	Transcriptional regulator
HKX69_RS27470	COG1410	methionine synthase
HKX69_RS27470	COG0646	methionine synthase
HKX69_RS27480	COG4166	transmembrane transport
HKX69_RS27485	COG2197	response regulator
HKX69_RS27495	COG0517	IMP dehydrogenase activity
HKX69_RS27495	COG1994	Peptidase M50
HKX69_RS27515	COG1222	aaa ATPase
HKX69_RS27520	COG4122	O-methyltransferase activity
HKX69_RS27535	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HKX69_RS27540	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HKX69_RS27545	COG1609	Transcriptional regulator
HKX69_RS27555	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HKX69_RS27590	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HKX69_RS27595	COG0805	protein transport
HKX69_RS27630	COG0564	pseudouridine synthase activity
HKX69_RS27645	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HKX69_RS27670	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HKX69_RS27675	COG2186	Transcriptional regulator
HKX69_RS27680	COG0174	glutamine synthetase
HKX69_RS27685	COG1012	belongs to the aldehyde dehydrogenase family
HKX69_RS27725	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HKX69_RS27730	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HKX69_RS27735	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HKX69_RS27740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HKX69_RS27745	COG5002	protein histidine kinase activity
HKX69_RS27750	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HKX69_RS27755	COG0072	phenylalanine-tRNA ligase activity
HKX69_RS27755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HKX69_RS27785	COG1649	PFAM Uncharacterised BCR, COG1649
HKX69_RS27795	COG0697	spore germination
HKX69_RS27835	COG0463	Glycosyl transferase, family 2
HKX69_RS27845	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HKX69_RS27850	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HKX69_RS27855	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HKX69_RS27860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HKX69_RS27865	COG1438	arginine binding
HKX69_RS27900	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HKX69_RS27900	COG1017	nitric oxide dioxygenase activity
HKX69_RS27905	COG0745	RESPONSE REGULATOR receiver
HKX69_RS27910	COG2205	protein histidine kinase activity
HKX69_RS27930	COG0137	argininosuccinate synthase activity
HKX69_RS27935	COG0165	Argininosuccinate lyase
HKX69_RS27950	COG0477	Major facilitator Superfamily
HKX69_RS27955	COG2132	Multicopper oxidase
HKX69_RS27960	COG0318	PFAM AMP-dependent synthetase and ligase
HKX69_RS27960	COG0204	Acyl-transferase
HKX69_RS27990	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HKX69_RS27995	COG2011	ABC-type metal ion transport system permease component
HKX69_RS28020	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HKX69_RS28025	COG1648	precorrin-2 dehydrogenase activity
HKX69_RS28025	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HKX69_RS28080	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HKX69_RS28130	COG0596	Alpha beta hydrolase
HKX69_RS28145	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HKX69_RS28160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HKX69_RS28180	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HKX69_RS28185	COG1560	Kdo2-lipid A biosynthetic process
HKX69_RS28190	COG0438	transferase activity, transferring glycosyl groups
HKX69_RS28200	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HKX69_RS28205	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HKX69_RS28210	COG0217	transcriptional regulatory protein
HKX69_RS28215	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HKX69_RS28220	COG0632	four-way junction helicase activity
HKX69_RS28225	COG2255	four-way junction helicase activity
HKX69_RS28235	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HKX69_RS28240	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HKX69_RS28245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HKX69_RS28250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HKX69_RS28255	COG1196	nuclear chromosome segregation
HKX69_RS28260	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HKX69_RS28270	COG0124	histidyl-tRNA synthetase
HKX69_RS28285	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HKX69_RS28305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HKX69_RS28310	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HKX69_RS28320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HKX69_RS28325	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HKX69_RS28330	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HKX69_RS28335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HKX69_RS28345	COG0006	proline dipeptidase activity
HKX69_RS28350	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HKX69_RS28355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HKX69_RS28365	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HKX69_RS28370	COG0540	Belongs to the ATCase OTCase family
HKX69_RS28375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HKX69_RS28385	COG0505	Belongs to the CarA family
HKX69_RS28390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HKX69_RS28395	COG0167	dihydroorotate dehydrogenase activity
HKX69_RS28400	COG0284	orotidine-5'-phosphate decarboxylase activity
HKX69_RS28410	COG0194	GDP metabolic process
HKX69_RS28425	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HKX69_RS28440	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HKX69_RS28450	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HKX69_RS28455	COG2390	Transcriptional regulator
HKX69_RS28475	COG0531	amino acid
HKX69_RS28485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HKX69_RS28500	COG2233	PERMEase
HKX69_RS28515	COG0738	Major facilitator superfamily
HKX69_RS28520	COG1940	carbohydrate kinase activity
HKX69_RS28520	COG1846	Transcriptional regulator
HKX69_RS28535	COG3201	nicotinamide mononucleotide transporter
HKX69_RS28540	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HKX69_RS28540	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HKX69_RS28545	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HKX69_RS28550	COG0140	phosphoribosyl-ATP diphosphatase activity
HKX69_RS28555	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HKX69_RS28615	COG1960	acyl-CoA dehydrogenase activity
HKX69_RS28635	COG0463	Glycosyl transferase, family 2
HKX69_RS28650	COG2270	Major facilitator Superfamily
HKX69_RS28660	COG2364	Membrane
HKX69_RS28665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKX69_RS28695	COG0438	transferase activity, transferring glycosyl groups
HKX69_RS28700	COG2755	lipolytic protein G-D-S-L family
HKX69_RS28705	COG1984	allophanate hydrolase subunit 2
HKX69_RS28710	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HKX69_RS28715	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HKX69_RS28720	COG4336	lyase activity
HKX69_RS28725	COG2814	Major facilitator Superfamily
HKX69_RS28760	COG2018	Roadblock/LC7 domain
HKX69_RS28780	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HKX69_RS28785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HKX69_RS28805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HKX69_RS28815	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HKX69_RS28845	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HKX69_RS28865	COG1716	ATPase activity
HKX69_RS28885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HKX69_RS28895	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HKX69_RS28895	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HKX69_RS28915	COG0725	ABC transporter, periplasmic molybdate-binding protein
HKX69_RS28940	COG3507	Belongs to the glycosyl hydrolase 43 family
HKX69_RS29000	COG0697	spore germination
HKX69_RS29040	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HKX69_RS29080	COG0747	negative chemotaxis
HKX69_RS29085	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HKX69_RS29100	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HKX69_RS29120	COG1968	undecaprenyl-diphosphatase activity
HKX69_RS29130	COG0183	Belongs to the thiolase family
HKX69_RS29150	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HKX69_RS29200	COG0110	maltose O-acetyltransferase activity
HKX69_RS29225	COG0640	Transcriptional regulator
HKX69_RS29235	COG0531	amino acid
HKX69_RS29240	COG1832	CoA-binding protein
HKX69_RS29255	COG1739	Uncharacterized protein family UPF0029
HKX69_RS29260	COG0420	3'-5' exonuclease activity
HKX69_RS29265	COG0419	ATPase involved in DNA repair
HKX69_RS29275	COG1522	sequence-specific DNA binding
HKX69_RS29295	COG2197	response regulator
HKX69_RS29300	COG4585	Histidine kinase
HKX69_RS29330	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS29345	COG0626	cystathionine gamma-synthase activity
HKX69_RS29360	COG0596	Alpha beta hydrolase
HKX69_RS29370	COG1595	DNA-templated transcription, initiation
HKX69_RS29375	COG2188	Transcriptional regulator
HKX69_RS29380	COG1940	carbohydrate kinase activity
HKX69_RS29385	COG2197	response regulator
HKX69_RS29390	COG4585	Histidine kinase
HKX69_RS29410	COG3663	DNA glycosylase
HKX69_RS29415	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HKX69_RS29620	COG0456	acetyltransferase
HKX69_RS29635	COG2226	methyltransferase
HKX69_RS29640	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HKX69_RS29645	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HKX69_RS29650	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HKX69_RS29655	COG0156	8-amino-7-oxononanoate synthase activity
HKX69_RS29685	COG0740	serine-type endopeptidase activity
HKX69_RS29695	COG0831	urea catabolic process
HKX69_RS29700	COG0832	Belongs to the urease beta subunit family
HKX69_RS29705	COG0804	urea catabolic process
HKX69_RS29710	COG0830	nickel cation binding
HKX69_RS29715	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HKX69_RS29720	COG0829	nickel cation binding
HKX69_RS29735	COG0204	Acyl-transferase
HKX69_RS29755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HKX69_RS29760	COG1834	amidinotransferase
HKX69_RS29765	COG1522	sequence-specific DNA binding
HKX69_RS29780	COG0205	6-phosphofructokinase activity
HKX69_RS29785	COG3442	glutamine amidotransferase
HKX69_RS29795	COG0242	peptide deformylase activity
HKX69_RS29805	COG1960	acyl-CoA dehydrogenase activity
HKX69_RS29815	COG2124	cytochrome p450
HKX69_RS29820	COG3424	synthase
HKX69_RS29840	COG1793	dna ligase
HKX69_RS29845	COG0492	ferredoxin-NADP+ reductase activity
HKX69_RS29860	COG1960	acyl-CoA dehydrogenase activity
HKX69_RS29865	COG1960	acyl-CoA dehydrogenase activity
HKX69_RS29895	COG0586	Pfam SNARE associated Golgi protein
HKX69_RS29905	COG0745	RESPONSE REGULATOR receiver
HKX69_RS29910	COG2205	protein histidine kinase activity
HKX69_RS29920	COG0583	DNA-binding transcription factor activity
HKX69_RS29930	COG1012	belongs to the aldehyde dehydrogenase family
HKX69_RS29950	COG1113	amino acid transport
HKX69_RS29955	COG1940	carbohydrate kinase activity
HKX69_RS29955	COG1846	Transcriptional regulator
HKX69_RS29980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HKX69_RS30055	COG2018	Roadblock/LC7 domain
HKX69_RS30065	COG1946	Acyl-CoA thioesterase
HKX69_RS30080	COG0254	rRNA binding
HKX69_RS30090	COG1132	(ABC) transporter
HKX69_RS30120	COG1132	(ABC) transporter
HKX69_RS30125	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HKX69_RS30130	COG2072	flavoprotein involved in K transport
HKX69_RS30135	COG0432	Pfam Uncharacterised protein family UPF0047
HKX69_RS30155	COG0477	Major facilitator Superfamily
HKX69_RS30160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HKX69_RS30185	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HKX69_RS30205	COG1960	acyl-CoA dehydrogenase activity
HKX69_RS30225	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HKX69_RS30230	COG1902	pentaerythritol trinitrate reductase activity
HKX69_RS30235	COG0640	Transcriptional regulator
HKX69_RS30240	COG2233	PERMEase
HKX69_RS30270	COG0671	phosphoesterase, PA-phosphatase related
HKX69_RS30310	COG0584	glycerophosphoryl diester phosphodiesterase
HKX69_RS30355	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HKX69_RS30375	COG3345	alpha-galactosidase
HKX69_RS30385	COG1660	Displays ATPase and GTPase activities
HKX69_RS30395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HKX69_RS30400	COG0445	tRNA wobble uridine modification
HKX69_RS30415	COG4585	Histidine kinase
HKX69_RS30420	COG2197	response regulator
HKX69_RS30440	COG3579	cysteine-type endopeptidase activity
HKX69_RS30450	COG2813	Specifically methylates the guanine in position
HKX69_RS30460	COG1940	carbohydrate kinase activity
HKX69_RS30520	COG2124	cytochrome p450
HKX69_RS30525	COG2124	cytochrome p450
HKX69_RS30530	COG1024	Enoyl-CoA hydratase
HKX69_RS30540	COG1349	DNA-binding transcription factor activity
HKX69_RS30575	COG1215	transferase activity, transferring glycosyl groups
HKX69_RS30605	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS30620	COG3328	transposase activity
HKX69_RS30625	COG0577	efflux transmembrane transporter activity
HKX69_RS30625	COG1136	(ABC) transporter
HKX69_RS30630	COG0577	efflux transmembrane transporter activity
HKX69_RS30635	COG4585	Histidine kinase
HKX69_RS30640	COG2197	response regulator
HKX69_RS30655	COG2197	response regulator
HKX69_RS30660	COG4585	Histidine kinase
HKX69_RS30675	COG0671	phosphoesterase, PA-phosphatase related
HKX69_RS30680	COG0671	phosphoesterase, PA-phosphatase related
HKX69_RS30685	COG0586	Pfam SNARE associated Golgi protein
HKX69_RS30710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKX69_RS30720	COG0561	phosphatase activity
HKX69_RS30730	COG3903	Transcriptional regulator
HKX69_RS30730	COG3629	intracellular signal transduction
HKX69_RS30745	COG2814	Major facilitator Superfamily
HKX69_RS30765	COG0596	Alpha beta hydrolase
HKX69_RS30770	COG0596	Alpha beta hydrolase
HKX69_RS30780	COG3548	integral membrane protein
HKX69_RS30785	COG2814	Major facilitator Superfamily
HKX69_RS30805	COG2124	cytochrome p450
HKX69_RS30850	COG1051	belongs to the nudix hydrolase family
HKX69_RS30880	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HKX69_RS30895	COG1733	regulation of RNA biosynthetic process
HKX69_RS30900	COG2340	Cysteine-rich secretory protein family
HKX69_RS30940	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HKX69_RS30950	COG0346	lactoylglutathione lyase activity
HKX69_RS30960	COG2197	response regulator
HKX69_RS30975	COG0395	ABC-type sugar transport system, permease component
HKX69_RS30980	COG1175	transmembrane transport
HKX69_RS31010	COG1968	undecaprenyl-diphosphatase activity
HKX69_RS31015	COG2186	Transcriptional regulator
HKX69_RS31020	COG1113	amino acid transport
HKX69_RS31035	COG2066	Belongs to the glutaminase family
HKX69_RS31045	COG1686	Belongs to the peptidase S11 family
HKX69_RS31050	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HKX69_RS31080	COG2226	methyltransferase
HKX69_RS31085	COG2188	Transcriptional regulator
HKX69_RS31095	COG3458	cephalosporin-C deacetylase activity
HKX69_RS31110	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HKX69_RS31130	COG2890	protein-(glutamine-N5) methyltransferase activity
HKX69_RS31150	COG0446	pyridine nucleotide-disulphide oxidoreductase
HKX69_RS31150	COG1902	pentaerythritol trinitrate reductase activity
HKX69_RS31175	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HKX69_RS31180	COG1461	Dihydroxyacetone kinase
HKX69_RS31185	COG2376	Dihydroxyacetone kinase
HKX69_RS31190	COG1554	hydrolase, family 65, central catalytic
HKX69_RS31200	COG2124	cytochrome p450
HKX69_RS31225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HKX69_RS31250	COG0438	transferase activity, transferring glycosyl groups
HKX69_RS31255	COG0297	glycogen (starch) synthase activity
HKX69_RS31260	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HKX69_RS31265	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HKX69_RS31265	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HKX69_RS31320	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HKX69_RS31325	COG0318	PFAM AMP-dependent synthetase and ligase
HKX69_RS31335	COG3415	Transposase
HKX69_RS31335	COG2801	Transposase and inactivated derivatives
HKX69_RS31340	COG0640	Transcriptional regulator
HKX69_RS31350	COG0596	Alpha beta hydrolase
HKX69_RS31385	COG0510	thiamine kinase activity
HKX69_RS31405	COG0673	inositol 2-dehydrogenase activity
HKX69_RS31415	COG0367	asparagine synthase
HKX69_RS31470	COG3250	beta-galactosidase activity
HKX69_RS31475	COG1940	carbohydrate kinase activity
HKX69_RS31480	COG0531	amino acid
HKX69_RS31490	COG0640	Transcriptional regulator
HKX69_RS31505	COG0702	epimerase
HKX69_RS31515	COG0431	NADPH-dependent FMN reductase
HKX69_RS31535	COG0667	Aldo Keto reductase
HKX69_RS31550	COG0346	lactoylglutathione lyase activity
HKX69_RS31555	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HKX69_RS31565	COG0583	DNA-binding transcription factor activity
HKX69_RS31570	COG0667	Aldo Keto reductase
HKX69_RS31590	COG1191	sigma factor activity
HKX69_RS31595	COG1396	sequence-specific DNA binding
HKX69_RS31615	COG0328	RNA-DNA hybrid ribonuclease activity
HKX69_RS31620	COG2304	oxidoreductase activity
HKX69_RS31655	COG3647	Membrane
HKX69_RS31665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKX69_RS31670	COG0515	serine threonine protein kinase
HKX69_RS31670	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HKX69_RS31705	COG3227	Zinc metalloprotease (Elastase)
HKX69_RS31725	COG0589	response to stress
HKX69_RS31735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HKX69_RS31775	COG5002	protein histidine kinase activity
HKX69_RS31835	COG1252	NADH dehydrogenase
HKX69_RS31855	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HKX69_RS31860	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HKX69_RS31865	COG3281	Trehalose synthase
HKX69_RS31875	COG0366	Alpha amylase catalytic
HKX69_RS31910	COG1846	Transcriptional regulator
HKX69_RS31920	COG0842	Transport permease protein
HKX69_RS31930	COG0181	hydroxymethylbilane synthase activity
HKX69_RS31940	COG0477	Major facilitator Superfamily
HKX69_RS31950	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HKX69_RS31955	COG1414	Transcriptional regulator
HKX69_RS32000	COG0667	Aldo Keto reductase
HKX69_RS32010	COG0656	L-ascorbic acid biosynthetic process
HKX69_RS32015	COG1609	Transcriptional regulator
HKX69_RS32020	COG1621	beta-fructofuranosidase activity
HKX69_RS32025	COG0395	ABC-type sugar transport system, permease component
HKX69_RS32030	COG1175	transmembrane transport
HKX69_RS32040	COG1621	beta-fructofuranosidase activity
HKX69_RS32085	COG0009	L-threonylcarbamoyladenylate synthase
HKX69_RS32095	COG0477	Major facilitator Superfamily
HKX69_RS32130	COG0673	inositol 2-dehydrogenase activity
HKX69_RS32180	COG0583	DNA-binding transcription factor activity
HKX69_RS32185	COG3291	Pkd domain containing protein
HKX69_RS32210	COG2267	carboxylic ester hydrolase activity
HKX69_RS32245	COG0709	Synthesizes selenophosphate from selenide and ATP
HKX69_RS32260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HKX69_RS32285	COG0437	4 iron, 4 sulfur cluster binding
HKX69_RS32290	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HKX69_RS32325	COG0586	Pfam SNARE associated Golgi protein
HKX69_RS32345	COG0667	Aldo Keto reductase
HKX69_RS32420	COG0640	Transcriptional regulator
HKX69_RS32460	COG0628	permease
HKX69_RS32495	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HKX69_RS32495	COG1024	Enoyl-CoA hydratase
HKX69_RS32500	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HKX69_RS32510	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HKX69_RS32515	COG0298	carbon dioxide binding
HKX69_RS32530	COG0375	protein maturation
HKX69_RS32555	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HKX69_RS32575	COG0583	DNA-binding transcription factor activity
HKX69_RS32590	COG1482	cell wall glycoprotein biosynthetic process
HKX69_RS32605	COG0701	Predicted permease
HKX69_RS32615	COG2801	Transposase and inactivated derivatives
HKX69_RS32615	COG3415	Transposase
HKX69_RS32630	COG1295	ribonuclease BN
HKX69_RS32635	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS32650	COG3896	Chloramphenicol phosphotransferase-like protein
HKX69_RS32655	COG3903	Transcriptional regulator
HKX69_RS32655	COG3629	intracellular signal transduction
HKX69_RS32705	COG0604	alcohol dehydrogenase
HKX69_RS32705	COG3321	synthase
HKX69_RS32715	COG0577	efflux transmembrane transporter activity
HKX69_RS32715	COG1136	(ABC) transporter
HKX69_RS32730	COG2197	response regulator
HKX69_RS32740	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS32750	COG2124	cytochrome p450
HKX69_RS32760	COG2267	carboxylic ester hydrolase activity
HKX69_RS32775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKX69_RS32795	COG4865	methylaspartate mutase activity
HKX69_RS32820	COG3973	AAA domain
HKX69_RS32900	COG0515	serine threonine protein kinase
HKX69_RS32915	COG2508	Transcriptional regulator
HKX69_RS32920	COG2267	carboxylic ester hydrolase activity
HKX69_RS32985	COG1042	CoA-binding domain protein
HKX69_RS32985	COG0045	succinate-CoA ligase (ADP-forming) activity
HKX69_RS32985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HKX69_RS33000	COG0516	GMP reductase activity
HKX69_RS33000	COG0517	IMP dehydrogenase activity
HKX69_RS33020	COG0574	Belongs to the PEP-utilizing enzyme family
HKX69_RS33020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HKX69_RS33035	COG1063	alcohol dehydrogenase
HKX69_RS33065	COG0589	response to stress
HKX69_RS33115	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HKX69_RS33120	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HKX69_RS33160	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HKX69_RS33165	COG0569	domain protein
HKX69_RS33175	COG0589	response to stress
HKX69_RS33225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HKX69_RS33230	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HKX69_RS33235	COG0022	dehydrogenase e1 component
HKX69_RS33235	COG0508	dehydrogenase complex catalyzes the overall conversion of
HKX69_RS33240	COG0508	dehydrogenase complex catalyzes the overall conversion of
HKX69_RS33250	COG1063	alcohol dehydrogenase
HKX69_RS33280	COG0517	IMP dehydrogenase activity
HKX69_RS33280	COG0516	GMP reductase activity
HKX69_RS33305	COG3328	transposase activity
HKX69_RS33315	COG3328	transposase activity
HKX69_RS33330	COG0714	Associated with various cellular activities
HKX69_RS33340	COG0583	DNA-binding transcription factor activity
HKX69_RS33350	COG3250	beta-galactosidase activity
HKX69_RS33360	COG1404	Belongs to the peptidase S8 family
HKX69_RS33375	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HKX69_RS33385	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HKX69_RS33390	COG0655	NAD(P)H dehydrogenase (quinone) activity
HKX69_RS33420	COG2226	methyltransferase
HKX69_RS33440	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HKX69_RS33455	COG4977	sequence-specific DNA binding
HKX69_RS33465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HKX69_RS33475	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HKX69_RS33510	COG3345	alpha-galactosidase
HKX69_RS33515	COG1846	Transcriptional regulator
HKX69_RS33515	COG1940	carbohydrate kinase activity
HKX69_RS33560	COG0431	NADPH-dependent FMN reductase
HKX69_RS33580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HKX69_RS33600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HKX69_RS33615	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HKX69_RS33645	COG0747	negative chemotaxis
HKX69_RS33650	COG0601	transmembrane transport
HKX69_RS33655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HKX69_RS33665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKX69_RS33680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKX69_RS33695	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS33700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HKX69_RS33730	COG0604	alcohol dehydrogenase
HKX69_RS33735	COG0596	Alpha beta hydrolase
HKX69_RS33740	COG2208	phosphoserine phosphatase activity
HKX69_RS33740	COG2770	Histidine kinase
HKX69_RS33750	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HKX69_RS33760	COG0183	Belongs to the thiolase family
HKX69_RS33765	COG0583	DNA-binding transcription factor activity
HKX69_RS33770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKX69_RS33780	COG1177	transmembrane transport
HKX69_RS33785	COG1176	ABC-type spermidine putrescine transport system, permease component I
HKX69_RS33795	COG3842	ATPase activity
HKX69_RS33825	COG1902	pentaerythritol trinitrate reductase activity
HKX69_RS33830	COG1846	Transcriptional regulator
HKX69_RS33855	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HKX69_RS33860	COG1414	Transcriptional regulator
HKX69_RS33865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKX69_RS33880	COG3842	ATPase activity
HKX69_RS33900	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HKX69_RS33910	COG0673	inositol 2-dehydrogenase activity
HKX69_RS33945	COG2814	Major facilitator Superfamily
HKX69_RS33955	COG0583	DNA-binding transcription factor activity
HKX69_RS33990	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS34045	COG2205	protein histidine kinase activity
HKX69_RS34050	COG0745	RESPONSE REGULATOR receiver
HKX69_RS34135	COG1609	Transcriptional regulator
HKX69_RS34145	COG2222	sugar isomerase
HKX69_RS34160	COG0191	fructose-bisphosphate aldolase activity
HKX69_RS34175	COG0395	ABC-type sugar transport system, permease component
HKX69_RS34180	COG1175	transmembrane transport
HKX69_RS34185	COG2182	Extracellular solute-binding protein
HKX69_RS34190	COG2188	Transcriptional regulator
HKX69_RS34200	COG2226	methyltransferase
HKX69_RS34260	COG1028	Short-chain dehydrogenase reductase Sdr
HKX69_RS34300	COG2124	cytochrome p450
HKX69_RS34370	COG0789	Transcriptional regulator
HKX69_RS34385	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HKX69_RS34385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HKX69_RS34395	COG3467	pyridoxamine 5'-phosphate
HKX69_RS34400	COG0028	Belongs to the TPP enzyme family
HKX69_RS34405	COG0069	glutamate synthase activity
HKX69_RS34425	COG3227	Zinc metalloprotease (Elastase)
HKX69_RS34440	COG0596	Alpha beta hydrolase
HKX69_RS34450	COG0667	Aldo Keto reductase
HKX69_RS34455	COG2084	Dehydrogenase
HKX69_RS34485	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HKX69_RS34495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases