locus-tag	class	description
FH965_RS00020	COG0583	DNA-binding transcription factor activity
FH965_RS00025	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FH965_RS00030	COG3655	Transcriptional regulator
FH965_RS00060	COG1733	regulation of RNA biosynthetic process
FH965_RS00065	COG0604	alcohol dehydrogenase
FH965_RS00095	COG0148	phosphopyruvate hydratase activity
FH965_RS00110	COG0590	tRNA wobble adenosine to inosine editing
FH965_RS00125	COG0583	DNA-binding transcription factor activity
FH965_RS00150	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FH965_RS00195	COG0438	transferase activity, transferring glycosyl groups
FH965_RS00205	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FH965_RS00220	COG4310	Domain of unknown function (DUF2172)
FH965_RS00230	COG1216	Glycosyl transferase, family 2
FH965_RS00240	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FH965_RS00245	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FH965_RS00265	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FH965_RS00285	COG0318	PFAM AMP-dependent synthetase and ligase
FH965_RS00305	COG2223	nitrite transmembrane transporter activity
FH965_RS00320	COG3397	chitin binding
FH965_RS00345	COG3251	PFAM MbtH domain protein
FH965_RS00360	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FH965_RS00400	COG2945	thiolester hydrolase activity
FH965_RS00400	COG0596	Alpha beta hydrolase
FH965_RS00410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FH965_RS00425	COG2814	Major facilitator Superfamily
FH965_RS00495	COG2197	response regulator
FH965_RS00500	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FH965_RS00505	COG0667	Aldo Keto reductase
FH965_RS00515	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FH965_RS00570	COG0583	DNA-binding transcription factor activity
FH965_RS00580	COG0604	alcohol dehydrogenase
FH965_RS00655	COG1252	NADH dehydrogenase
FH965_RS00685	COG2318	DinB family
FH965_RS00705	COG0393	Putative heavy-metal-binding
FH965_RS00710	COG0494	nUDIX hydrolase
FH965_RS00745	COG2271	Major facilitator Superfamily
FH965_RS00770	COG2197	response regulator
FH965_RS00820	COG4552	Acetyltransferase involved in intracellular survival and related
FH965_RS00860	COG4977	sequence-specific DNA binding
FH965_RS00870	COG2508	Transcriptional regulator
FH965_RS00875	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FH965_RS00875	COG1672	PFAM Archaeal ATPase
FH965_RS00900	COG0395	ABC-type sugar transport system, permease component
FH965_RS00905	COG1175	transmembrane transport
FH965_RS00910	COG1653	transport
FH965_RS00930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FH965_RS00935	COG0783	Belongs to the Dps family
FH965_RS00940	COG2259	Doxx family
FH965_RS00945	COG1335	isochorismatase
FH965_RS00960	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FH965_RS01035	COG1056	cytidyltransferase-related domain
FH965_RS01035	COG1051	belongs to the nudix hydrolase family
FH965_RS01050	COG2084	Dehydrogenase
FH965_RS01055	COG1733	regulation of RNA biosynthetic process
FH965_RS01065	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FH965_RS01125	COG4221	oxidoreductase activity
FH965_RS01135	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FH965_RS01140	COG0640	Transcriptional regulator
FH965_RS01170	COG1253	flavin adenine dinucleotide binding
FH965_RS01250	COG2197	response regulator
FH965_RS01255	COG0009	L-threonylcarbamoyladenylate synthase
FH965_RS01265	COG1012	belongs to the aldehyde dehydrogenase family
FH965_RS01290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FH965_RS01295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FH965_RS01300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FH965_RS01330	COG1819	glycosyl
FH965_RS01335	COG0477	Major facilitator Superfamily
FH965_RS01350	COG4585	Histidine kinase
FH965_RS01355	COG2197	response regulator
FH965_RS01415	COG2124	cytochrome p450
FH965_RS01445	COG3409	Peptidoglycan-binding domain 1 protein
FH965_RS01445	COG0793	Belongs to the peptidase S41A family
FH965_RS01450	COG1522	sequence-specific DNA binding
FH965_RS01470	COG3979	chitinase
FH965_RS01585	COG0739	heme binding
FH965_RS01690	COG2197	response regulator
FH965_RS01695	COG4585	Histidine kinase
FH965_RS01710	COG0516	GMP reductase activity
FH965_RS01710	COG0517	IMP dehydrogenase activity
FH965_RS01730	COG0045	succinate-CoA ligase (ADP-forming) activity
FH965_RS01730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FH965_RS01730	COG1042	CoA-binding domain protein
FH965_RS01770	COG0574	Belongs to the PEP-utilizing enzyme family
FH965_RS01770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FH965_RS01775	COG1012	belongs to the aldehyde dehydrogenase family
FH965_RS01775	COG1454	alcohol dehydrogenase
FH965_RS01785	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FH965_RS01795	COG2824	Alkylphosphonate utilization operon protein PhnA
FH965_RS01805	COG0659	secondary active sulfate transmembrane transporter activity
FH965_RS01870	COG1652	LysM domain
FH965_RS01900	COG0589	response to stress
FH965_RS01940	COG0142	geranyltranstransferase activity
FH965_RS01945	COG2124	cytochrome p450
FH965_RS01950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FH965_RS01965	COG0494	nUDIX hydrolase
FH965_RS01970	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FH965_RS02040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FH965_RS02045	COG1937	Protein conserved in bacteria
FH965_RS02055	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FH965_RS02055	COG1796	DNA polymerase
FH965_RS02060	COG1012	belongs to the aldehyde dehydrogenase family
FH965_RS02065	COG2197	response regulator
FH965_RS02070	COG4585	Histidine kinase
FH965_RS02085	COG0515	serine threonine protein kinase
FH965_RS02110	COG1136	(ABC) transporter
FH965_RS02175	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS02185	COG2267	carboxylic ester hydrolase activity
FH965_RS02225	COG1733	regulation of RNA biosynthetic process
FH965_RS02230	COG0702	epimerase
FH965_RS02245	COG2813	Specifically methylates the guanine in position
FH965_RS02250	COG2318	DinB family
FH965_RS02265	COG0515	serine threonine protein kinase
FH965_RS02280	COG0583	DNA-binding transcription factor activity
FH965_RS02285	COG0473	3-isopropylmalate dehydrogenase activity
FH965_RS02290	COG1301	dicarboxylic acid transport
FH965_RS02295	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FH965_RS02340	COG1960	acyl-CoA dehydrogenase activity
FH965_RS02385	COG1376	ErfK ybiS ycfS ynhG family protein
FH965_RS02405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FH965_RS02415	COG0076	glutamate decarboxylase activity
FH965_RS02460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FH965_RS02500	COG1733	regulation of RNA biosynthetic process
FH965_RS02605	COG1349	DNA-binding transcription factor activity
FH965_RS02610	COG0640	Transcriptional regulator
FH965_RS02620	COG0640	Transcriptional regulator
FH965_RS02665	COG1132	(ABC) transporter
FH965_RS02670	COG1132	(ABC) transporter
FH965_RS02810	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FH965_RS02835	COG2326	polyphosphate kinase activity
FH965_RS02840	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
FH965_RS02860	COG2197	response regulator
FH965_RS02865	COG4585	Histidine kinase
FH965_RS02865	COG2203	Gaf domain
FH965_RS02875	COG3408	Glycogen debranching enzyme
FH965_RS02875	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
FH965_RS02880	COG2124	cytochrome p450
FH965_RS02935	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FH965_RS02960	COG0395	ABC-type sugar transport system, permease component
FH965_RS02990	COG2376	Dihydroxyacetone kinase
FH965_RS03015	COG1162	GTPase activity
FH965_RS03025	COG1597	lipid kinase activity
FH965_RS03035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FH965_RS03040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FH965_RS03050	COG3239	Fatty acid desaturase
FH965_RS03085	COG1012	belongs to the aldehyde dehydrogenase family
FH965_RS03095	COG3629	intracellular signal transduction
FH965_RS03115	COG0477	Major facilitator Superfamily
FH965_RS03125	COG2124	cytochrome p450
FH965_RS03165	COG2353	YceI-like domain
FH965_RS03195	COG3622	Belongs to the hyi family
FH965_RS03205	COG3395	kinase activity
FH965_RS03255	COG0501	Belongs to the peptidase M48B family
FH965_RS03265	COG0604	alcohol dehydrogenase
FH965_RS03265	COG3321	synthase
FH965_RS03280	COG1309	transcriptional regulator
FH965_RS03285	COG0778	Nitroreductase
FH965_RS03290	COG0515	serine threonine protein kinase
FH965_RS03290	COG2815	serine threonine protein kinase
FH965_RS03305	COG1357	PFAM Pentapeptide repeats (8 copies)
FH965_RS03310	COG2124	cytochrome p450
FH965_RS03315	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FH965_RS03320	COG2070	2-Nitropropane dioxygenase
FH965_RS03320	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FH965_RS03325	COG3425	synthase
FH965_RS03330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FH965_RS03335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FH965_RS03350	COG4221	oxidoreductase activity
FH965_RS03350	COG3321	synthase
FH965_RS03350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FH965_RS03350	COG0300	oxidoreductase activity
FH965_RS03355	COG3321	synthase
FH965_RS03355	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS03355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FH965_RS03355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FH965_RS03355	COG3321	synthase
FH965_RS03355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FH965_RS03355	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS03355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FH965_RS03355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FH965_RS03355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FH965_RS03360	COG3321	synthase
FH965_RS03360	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS03360	COG0318	PFAM AMP-dependent synthetase and ligase
FH965_RS03360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FH965_RS03360	COG0300	oxidoreductase activity
FH965_RS03375	COG1819	glycosyl
FH965_RS03385	COG3433	isochorismatase activity
FH965_RS03385	COG1535	isochorismatase
FH965_RS03390	COG1021	2,3-dihydroxybenzoate-AMP ligase
FH965_RS03395	COG1169	isochorismate synthase
FH965_RS03400	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS03415	COG0583	DNA-binding transcription factor activity
FH965_RS03480	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS03505	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FH965_RS03510	COG0596	Alpha beta hydrolase
FH965_RS03515	COG1309	transcriptional regulator
FH965_RS03540	COG1063	alcohol dehydrogenase
FH965_RS03615	COG0577	efflux transmembrane transporter activity
FH965_RS03615	COG1136	(ABC) transporter
FH965_RS03620	COG1136	(ABC) transporter
FH965_RS03620	COG0577	efflux transmembrane transporter activity
FH965_RS03625	COG2205	protein histidine kinase activity
FH965_RS03630	COG0745	RESPONSE REGULATOR receiver
FH965_RS03635	COG1595	DNA-templated transcription, initiation
FH965_RS03645	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FH965_RS03755	COG1309	transcriptional regulator
FH965_RS03805	COG2249	NAD(P)H dehydrogenase (quinone) activity
FH965_RS03835	COG4941	Belongs to the sigma-70 factor family
FH965_RS03840	COG3795	YCII-related domain
FH965_RS03860	COG0783	Belongs to the Dps family
FH965_RS03905	COG1309	transcriptional regulator
FH965_RS03920	COG1902	pentaerythritol trinitrate reductase activity
FH965_RS03955	COG0789	Transcriptional regulator
FH965_RS03960	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FH965_RS04025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FH965_RS04030	COG2197	response regulator
FH965_RS04040	COG0604	alcohol dehydrogenase
FH965_RS04040	COG3321	synthase
FH965_RS04055	COG3321	synthase
FH965_RS04055	COG0604	alcohol dehydrogenase
FH965_RS04070	COG1846	Transcriptional regulator
FH965_RS04075	COG0697	spore germination
FH965_RS04095	COG1511	domain protein
FH965_RS04100	COG0488	(ABC) transporter
FH965_RS04160	COG0697	spore germination
FH965_RS04165	COG0583	DNA-binding transcription factor activity
FH965_RS04185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH965_RS04210	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS04225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FH965_RS04255	COG2084	Dehydrogenase
FH965_RS04265	COG1280	lysine exporter protein (LysE YggA)
FH965_RS04280	COG2124	cytochrome p450
FH965_RS04330	COG0395	ABC-type sugar transport system, permease component
FH965_RS04335	COG1175	transmembrane transport
FH965_RS04365	COG0300	oxidoreductase activity
FH965_RS04365	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS04365	COG3321	synthase
FH965_RS04365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FH965_RS04365	COG0318	PFAM AMP-dependent synthetase and ligase
FH965_RS04375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FH965_RS04400	COG1473	amidohydrolase
FH965_RS04405	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FH965_RS04415	COG1396	sequence-specific DNA binding
FH965_RS04420	COG0740	serine-type endopeptidase activity
FH965_RS04425	COG0740	serine-type endopeptidase activity
FH965_RS04480	COG1250	3-hydroxyacyl-CoA dehydrogenase
FH965_RS04485	COG1404	Belongs to the peptidase S8 family
FH965_RS04490	COG0583	DNA-binding transcription factor activity
FH965_RS04530	COG3540	Alkaline phosphatase
FH965_RS04550	COG1595	DNA-templated transcription, initiation
FH965_RS04570	COG2197	response regulator
FH965_RS04595	COG4585	Histidine kinase
FH965_RS04605	COG0789	Transcriptional regulator
FH965_RS04610	COG0667	Aldo Keto reductase
FH965_RS04615	COG2226	methyltransferase
FH965_RS04695	COG0006	proline dipeptidase activity
FH965_RS04720	COG3938	Belongs to the proline racemase family
FH965_RS04725	COG1012	belongs to the aldehyde dehydrogenase family
FH965_RS04730	COG1802	Transcriptional regulator
FH965_RS04750	COG2824	Alkylphosphonate utilization operon protein PhnA
FH965_RS04765	COG0745	RESPONSE REGULATOR receiver
FH965_RS04770	COG2205	protein histidine kinase activity
FH965_RS04775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FH965_RS04780	COG1309	transcriptional regulator
FH965_RS04795	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FH965_RS04805	COG0640	Transcriptional regulator
FH965_RS04825	COG3594	Acyltransferase
FH965_RS04855	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FH965_RS04855	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FH965_RS04880	COG2197	response regulator
FH965_RS04885	COG4585	Histidine kinase
FH965_RS04890	COG2409	Drug exporters of the RND superfamily
FH965_RS04950	COG1113	amino acid transport
FH965_RS04970	COG2186	Transcriptional regulator
FH965_RS04975	COG2807	transmembrane transport
FH965_RS05015	COG0789	Transcriptional regulator
FH965_RS05090	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FH965_RS05100	COG0247	lactate metabolic process
FH965_RS05100	COG0277	FAD linked oxidase domain protein
FH965_RS05105	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FH965_RS05120	COG0477	Major facilitator Superfamily
FH965_RS05135	COG0494	nUDIX hydrolase
FH965_RS05150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH965_RS05160	COG1126	abc transporter atp-binding protein
FH965_RS05165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH965_RS05175	COG1609	Transcriptional regulator
FH965_RS05205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FH965_RS05235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FH965_RS05240	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FH965_RS05275	COG0596	Alpha beta hydrolase
FH965_RS05300	COG0574	Belongs to the PEP-utilizing enzyme family
FH965_RS05300	COG3848	Pyruvate phosphate dikinase
FH965_RS05305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FH965_RS05315	COG2409	Drug exporters of the RND superfamily
FH965_RS05330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FH965_RS05335	COG0492	ferredoxin-NADP+ reductase activity
FH965_RS05405	COG1414	Transcriptional regulator
FH965_RS05435	COG4214	carbohydrate transport
FH965_RS05455	COG1309	transcriptional regulator
FH965_RS05460	COG2072	flavoprotein involved in K transport
FH965_RS05470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FH965_RS05490	COG0366	Alpha amylase catalytic
FH965_RS05495	COG3833	ABC-type maltose transport systems, permease component
FH965_RS05500	COG1175	transmembrane transport
FH965_RS05505	COG2182	Extracellular solute-binding protein
FH965_RS05510	COG1609	Transcriptional regulator
FH965_RS05520	COG2910	NAD(P)H-binding
FH965_RS05525	COG3467	pyridoxamine 5'-phosphate
FH965_RS05530	COG1136	(ABC) transporter
FH965_RS05530	COG0577	efflux transmembrane transporter activity
FH965_RS05535	COG0577	efflux transmembrane transporter activity
FH965_RS05535	COG1136	(ABC) transporter
FH965_RS05575	COG1809	phosphosulfolactate synthase activity
FH965_RS05580	COG0318	PFAM AMP-dependent synthetase and ligase
FH965_RS05600	COG2124	cytochrome p450
FH965_RS05610	COG0475	glutathione-regulated potassium exporter activity
FH965_RS05620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FH965_RS05635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FH965_RS05640	COG1132	(ABC) transporter
FH965_RS05650	COG2205	protein histidine kinase activity
FH965_RS05655	COG0745	RESPONSE REGULATOR receiver
FH965_RS05660	COG2197	response regulator
FH965_RS05675	COG0697	spore germination
FH965_RS05685	COG1116	anion transmembrane transporter activity
FH965_RS05695	COG1285	pathogenesis
FH965_RS05705	COG3384	dioxygenase
FH965_RS05725	COG2124	cytochrome p450
FH965_RS05740	COG0438	transferase activity, transferring glycosyl groups
FH965_RS05750	COG2197	response regulator
FH965_RS05760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FH965_RS05785	COG1733	regulation of RNA biosynthetic process
FH965_RS05790	COG2226	methyltransferase
FH965_RS05800	COG0330	HflC and HflK could
FH965_RS05805	COG5492	domain, Protein
FH965_RS05825	COG2084	Dehydrogenase
FH965_RS05855	COG2409	Drug exporters of the RND superfamily
FH965_RS05895	COG0515	serine threonine protein kinase
FH965_RS05900	COG3896	Chloramphenicol phosphotransferase-like protein
FH965_RS05925	COG0367	asparagine synthase
FH965_RS05935	COG0673	inositol 2-dehydrogenase activity
FH965_RS05955	COG2860	membrane
FH965_RS05965	COG1335	isochorismatase
FH965_RS05980	COG1960	acyl-CoA dehydrogenase activity
FH965_RS05990	COG0242	peptide deformylase activity
FH965_RS06000	COG3442	glutamine amidotransferase
FH965_RS06005	COG0205	6-phosphofructokinase activity
FH965_RS06025	COG0204	Acyl-transferase
FH965_RS06035	COG0829	nickel cation binding
FH965_RS06040	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FH965_RS06050	COG0804	urea catabolic process
FH965_RS06055	COG0832	Belongs to the urease beta subunit family
FH965_RS06060	COG0831	urea catabolic process
FH965_RS06070	COG0740	serine-type endopeptidase activity
FH965_RS06105	COG0156	8-amino-7-oxononanoate synthase activity
FH965_RS06110	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FH965_RS06115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FH965_RS06120	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FH965_RS06125	COG2226	methyltransferase
FH965_RS06150	COG1136	(ABC) transporter
FH965_RS06150	COG0577	efflux transmembrane transporter activity
FH965_RS06180	COG0583	DNA-binding transcription factor activity
FH965_RS06195	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FH965_RS06200	COG0586	Pfam SNARE associated Golgi protein
FH965_RS06205	COG4585	Histidine kinase
FH965_RS06210	COG2201	protein-glutamate methylesterase activity
FH965_RS06230	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FH965_RS06260	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FH965_RS06275	COG1131	(ABC) transporter
FH965_RS06280	COG4585	Histidine kinase
FH965_RS06285	COG2197	response regulator
FH965_RS06290	COG1940	carbohydrate kinase activity
FH965_RS06295	COG2188	Transcriptional regulator
FH965_RS06300	COG1595	DNA-templated transcription, initiation
FH965_RS06320	COG2084	Dehydrogenase
FH965_RS06340	COG1522	sequence-specific DNA binding
FH965_RS06345	COG0419	ATPase involved in DNA repair
FH965_RS06350	COG0420	3'-5' exonuclease activity
FH965_RS06355	COG1739	Uncharacterized protein family UPF0029
FH965_RS06365	COG3629	intracellular signal transduction
FH965_RS06365	COG3903	Transcriptional regulator
FH965_RS06370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FH965_RS06390	COG1136	(ABC) transporter
FH965_RS06400	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FH965_RS06415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FH965_RS06425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FH965_RS06485	COG1832	CoA-binding protein
FH965_RS06515	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FH965_RS06590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FH965_RS06605	COG0183	Belongs to the thiolase family
FH965_RS06615	COG1968	undecaprenyl-diphosphatase activity
FH965_RS06675	COG0492	ferredoxin-NADP+ reductase activity
FH965_RS06700	COG1309	transcriptional regulator
FH965_RS06725	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FH965_RS06735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FH965_RS06755	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FH965_RS06805	COG0697	spore germination
FH965_RS06840	COG2890	protein-(glutamine-N5) methyltransferase activity
FH965_RS06855	COG2015	COG2015, Alkyl sulfatase and related hydrolases
FH965_RS06885	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FH965_RS06885	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FH965_RS06895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FH965_RS06935	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FH965_RS06970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FH965_RS06980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FH965_RS06995	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
FH965_RS07010	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FH965_RS07015	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FH965_RS07055	COG2146	nitrite reductase [NAD(P)H] activity
FH965_RS07060	COG1414	Transcriptional regulator
FH965_RS07075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FH965_RS07080	COG4638	Rieske (2fe-2S)
FH965_RS07105	COG2814	Major facilitator Superfamily
FH965_RS07110	COG4336	lyase activity
FH965_RS07115	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FH965_RS07120	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FH965_RS07125	COG1984	allophanate hydrolase subunit 2
FH965_RS07135	COG0438	transferase activity, transferring glycosyl groups
FH965_RS07140	COG0438	transferase activity, transferring glycosyl groups
FH965_RS07175	COG2364	Membrane
FH965_RS07195	COG0463	Glycosyl transferase, family 2
FH965_RS07230	COG1960	acyl-CoA dehydrogenase activity
FH965_RS07240	COG1309	transcriptional regulator
FH965_RS07285	COG4585	Histidine kinase
FH965_RS07290	COG2197	response regulator
FH965_RS07310	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FH965_RS07315	COG0140	phosphoribosyl-ATP diphosphatase activity
FH965_RS07320	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FH965_RS07325	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FH965_RS07325	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FH965_RS07330	COG3201	nicotinamide mononucleotide transporter
FH965_RS07350	COG1940	carbohydrate kinase activity
FH965_RS07350	COG1846	Transcriptional regulator
FH965_RS07355	COG0738	Major facilitator superfamily
FH965_RS07365	COG2233	PERMEase
FH965_RS07390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FH965_RS07405	COG0531	amino acid
FH965_RS07435	COG2390	Transcriptional regulator
FH965_RS07440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FH965_RS07445	COG2409	Drug exporters of the RND superfamily
FH965_RS07455	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FH965_RS07505	COG0194	GDP metabolic process
FH965_RS07515	COG0284	orotidine-5'-phosphate decarboxylase activity
FH965_RS07520	COG0167	dihydroorotate dehydrogenase activity
FH965_RS07525	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FH965_RS07530	COG0505	Belongs to the CarA family
FH965_RS07540	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FH965_RS07545	COG0540	Belongs to the ATCase OTCase family
FH965_RS07550	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FH965_RS07560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FH965_RS07565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FH965_RS07570	COG0006	proline dipeptidase activity
FH965_RS07580	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FH965_RS07585	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FH965_RS07590	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FH965_RS07595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FH965_RS07600	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FH965_RS07605	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FH965_RS07610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FH965_RS07630	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FH965_RS07645	COG0124	histidyl-tRNA synthetase
FH965_RS07655	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FH965_RS07660	COG1196	nuclear chromosome segregation
FH965_RS07665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FH965_RS07670	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FH965_RS07675	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FH965_RS07680	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FH965_RS07690	COG2255	four-way junction helicase activity
FH965_RS07695	COG0632	four-way junction helicase activity
FH965_RS07700	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FH965_RS07705	COG0217	transcriptional regulatory protein
FH965_RS07710	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FH965_RS07715	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FH965_RS07725	COG0438	transferase activity, transferring glycosyl groups
FH965_RS07730	COG1560	Kdo2-lipid A biosynthetic process
FH965_RS07735	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FH965_RS07755	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FH965_RS07770	COG5002	protein histidine kinase activity
FH965_RS07770	COG2176	DNA-directed DNA polymerase activity
FH965_RS07825	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FH965_RS07825	COG0512	Glutamine amidotransferase of anthranilate synthase
FH965_RS07885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FH965_RS07885	COG1648	precorrin-2 dehydrogenase activity
FH965_RS07890	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FH965_RS07905	COG1464	Belongs to the NlpA lipoprotein family
FH965_RS07910	COG1464	Belongs to the NlpA lipoprotein family
FH965_RS07915	COG2011	ABC-type metal ion transport system permease component
FH965_RS07920	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FH965_RS07950	COG0584	glycerophosphoryl diester phosphodiesterase
FH965_RS07955	COG0318	PFAM AMP-dependent synthetase and ligase
FH965_RS07955	COG0204	Acyl-transferase
FH965_RS07960	COG0477	Major facilitator Superfamily
FH965_RS07975	COG0165	Argininosuccinate lyase
FH965_RS07980	COG0137	argininosuccinate synthase activity
FH965_RS07985	COG0385	Bile acid
FH965_RS07990	COG1438	arginine binding
FH965_RS07995	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FH965_RS08000	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FH965_RS08005	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FH965_RS08010	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FH965_RS08015	COG2838	Isocitrate dehydrogenase
FH965_RS08020	COG0789	Transcriptional regulator
FH965_RS08030	COG0596	Alpha beta hydrolase
FH965_RS08035	COG0667	Aldo Keto reductase
FH965_RS08050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FH965_RS08055	COG0697	spore germination
FH965_RS08065	COG1649	PFAM Uncharacterised BCR, COG1649
FH965_RS08095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FH965_RS08095	COG0072	phenylalanine-tRNA ligase activity
FH965_RS08100	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FH965_RS08105	COG5002	protein histidine kinase activity
FH965_RS08110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FH965_RS08115	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FH965_RS08120	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FH965_RS08125	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FH965_RS08175	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS08180	COG1012	belongs to the aldehyde dehydrogenase family
FH965_RS08185	COG0174	glutamine synthetase
FH965_RS08190	COG2186	Transcriptional regulator
FH965_RS08195	COG0531	amino acid
FH965_RS08200	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FH965_RS08225	COG4176	ABC-type proline glycine betaine transport system permease component
FH965_RS08230	COG0517	IMP dehydrogenase activity
FH965_RS08230	COG4175	Glycine betaine
FH965_RS08235	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FH965_RS08250	COG0564	pseudouridine synthase activity
FH965_RS08290	COG0805	protein transport
FH965_RS08295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FH965_RS08330	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FH965_RS08340	COG1609	Transcriptional regulator
FH965_RS08345	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FH965_RS08350	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FH965_RS08365	COG4122	O-methyltransferase activity
FH965_RS08370	COG1222	aaa ATPase
FH965_RS08395	COG0517	IMP dehydrogenase activity
FH965_RS08395	COG1994	Peptidase M50
FH965_RS08405	COG2197	response regulator
FH965_RS08410	COG4166	transmembrane transport
FH965_RS08425	COG1410	methionine synthase
FH965_RS08425	COG0646	methionine synthase
FH965_RS08430	COG1414	Transcriptional regulator
FH965_RS08435	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FH965_RS08440	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FH965_RS08445	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FH965_RS08450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH965_RS08455	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
FH965_RS08460	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
FH965_RS08465	COG0235	Class ii aldolase
FH965_RS08470	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FH965_RS08470	COG0235	Class ii aldolase
FH965_RS08480	COG0402	S-adenosylhomocysteine deaminase activity
FH965_RS08485	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FH965_RS08495	COG2186	Transcriptional regulator
FH965_RS08505	COG4935	Belongs to the peptidase S8 family
FH965_RS08505	COG1404	Belongs to the peptidase S8 family
FH965_RS08515	COG0215	cysteine-tRNA ligase activity
FH965_RS08530	COG0406	alpha-ribazole phosphatase activity
FH965_RS08535	COG0598	Magnesium transport protein CorA
FH965_RS08545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH965_RS08550	COG0667	Aldo Keto reductase
FH965_RS08580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FH965_RS08590	COG0028	Belongs to the TPP enzyme family
FH965_RS08600	COG3012	SEC-C Motif Domain Protein
FH965_RS08605	COG2186	Transcriptional regulator
FH965_RS08610	COG3265	gluconokinase activity
FH965_RS08640	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FH965_RS08645	COG2149	membrane
FH965_RS08660	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FH965_RS08735	COG1960	acyl-CoA dehydrogenase activity
FH965_RS08755	COG2851	Citrate transporter
FH965_RS08765	COG0243	molybdopterin cofactor binding
FH965_RS08770	COG1309	transcriptional regulator
FH965_RS08775	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FH965_RS08780	COG2188	Transcriptional regulator
FH965_RS08790	COG0477	Major facilitator Superfamily
FH965_RS08820	COG1595	DNA-templated transcription, initiation
FH965_RS08845	COG2755	lipolytic protein G-D-S-L family
FH965_RS08860	COG0463	Glycosyl transferase, family 2
FH965_RS08890	COG1725	Transcriptional regulator
FH965_RS08935	COG4565	transcriptional regulatory protein
FH965_RS08950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FH965_RS08955	COG0587	DNA-directed DNA polymerase activity
FH965_RS08965	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FH965_RS08980	COG3227	Zinc metalloprotease (Elastase)
FH965_RS08995	COG0747	negative chemotaxis
FH965_RS09000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FH965_RS09010	COG0330	HflC and HflK could
FH965_RS09030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH965_RS09040	COG0765	amino acid transport
FH965_RS09045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH965_RS09055	COG1799	cell septum assembly
FH965_RS09060	COG1960	acyl-CoA dehydrogenase activity
FH965_RS09065	COG0477	Major facilitator Superfamily
FH965_RS09075	COG0671	phosphoesterase, PA-phosphatase related
FH965_RS09085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FH965_RS09100	COG0438	transferase activity, transferring glycosyl groups
FH965_RS09120	COG1137	ATPase activity
FH965_RS09130	COG3583	domain protein
FH965_RS09150	COG1160	GTP binding
FH965_RS09160	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FH965_RS09170	COG3753	Protein conserved in bacteria
FH965_RS09195	COG3541	Predicted nucleotidyltransferase
FH965_RS09200	COG1187	pseudouridine synthase activity
FH965_RS09205	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FH965_RS09210	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FH965_RS09225	COG0686	Belongs to the AlaDH PNT family
FH965_RS09235	COG0494	nUDIX hydrolase
FH965_RS09240	COG0504	CTP synthase activity
FH965_RS09245	COG3387	PFAM Glycoside hydrolase 15-related
FH965_RS09255	COG0297	glycogen (starch) synthase activity
FH965_RS09260	COG0497	DNA recombination
FH965_RS09270	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FH965_RS09290	COG1120	ATPase activity
FH965_RS09295	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH965_RS09300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH965_RS09310	COG0647	UMP catabolic process
FH965_RS09340	COG2094	Belongs to the DNA glycosylase MPG family
FH965_RS09350	COG1881	PFAM PEBP family protein
FH965_RS09370	COG1119	ATPase activity
FH965_RS09395	COG2197	response regulator
FH965_RS09400	COG4585	Histidine kinase
FH965_RS09405	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS09410	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FH965_RS09420	COG1716	ATPase activity
FH965_RS09420	COG1131	(ABC) transporter
FH965_RS09420	COG0842	Transport permease protein
FH965_RS09430	COG0560	Phosphoserine phosphatase
FH965_RS09430	COG3830	Belongs to the UPF0237 family
FH965_RS09455	COG2186	Transcriptional regulator
FH965_RS09465	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FH965_RS09470	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS09485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FH965_RS09505	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FH965_RS09510	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FH965_RS09535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FH965_RS09570	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS09585	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FH965_RS09600	COG3387	PFAM Glycoside hydrolase 15-related
FH965_RS09605	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS09650	COG0488	(ABC) transporter
FH965_RS09670	COG0235	Class ii aldolase
FH965_RS09690	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FH965_RS09695	COG1492	cobalamin metabolic process
FH965_RS09705	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FH965_RS09710	COG1797	cobyrinic acid a,c-diamide synthase activity
FH965_RS09735	COG1104	cysteine desulfurase activity
FH965_RS09740	COG0456	acetyltransferase
FH965_RS09745	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FH965_RS09750	COG1917	Cupin 2, conserved barrel domain protein
FH965_RS09755	COG5285	phytanoyl-CoA dioxygenase
FH965_RS09760	COG1902	pentaerythritol trinitrate reductase activity
FH965_RS09765	COG1846	Transcriptional regulator
FH965_RS09780	COG1733	regulation of RNA biosynthetic process
FH965_RS09785	COG0673	inositol 2-dehydrogenase activity
FH965_RS09800	COG1414	Transcriptional regulator
FH965_RS09810	COG4585	Histidine kinase
FH965_RS09815	COG2197	response regulator
FH965_RS09820	COG0768	penicillin binding
FH965_RS09830	COG1695	Transcriptional regulator
FH965_RS09855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FH965_RS09860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FH965_RS09870	COG1349	DNA-binding transcription factor activity
FH965_RS09885	COG0395	ABC-type sugar transport system, permease component
FH965_RS09890	COG1063	alcohol dehydrogenase
FH965_RS09955	COG1595	DNA-templated transcription, initiation
FH965_RS09970	COG2171	N-acyltransferase activity
FH965_RS09975	COG2814	Major facilitator Superfamily
FH965_RS09985	COG3226	Transcriptional regulator
FH965_RS09990	COG2076	Multidrug Resistance protein
FH965_RS10000	COG0822	iron-sulfur transferase activity
FH965_RS10005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FH965_RS10010	COG0396	ATPase activity
FH965_RS10020	COG0719	Fe-S assembly protein
FH965_RS10035	COG2746	aminoglycoside 3-N-acetyltransferase activity
FH965_RS10040	COG1131	(ABC) transporter
FH965_RS10050	COG1612	heme a metabolic process
FH965_RS10070	COG0109	protoheme IX farnesyltransferase activity
FH965_RS10085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FH965_RS10100	COG0363	glucosamine-6-phosphate deaminase activity
FH965_RS10110	COG0166	Belongs to the GPI family
FH965_RS10125	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FH965_RS10130	COG0149	triose-phosphate isomerase activity
FH965_RS10135	COG0126	phosphoglycerate kinase activity
FH965_RS10140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FH965_RS10145	COG1481	regulation of sporulation
FH965_RS10150	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FH965_RS10155	COG1660	Displays ATPase and GTPase activities
FH965_RS10195	COG2353	YceI-like domain
FH965_RS10200	COG1024	Enoyl-CoA hydratase
FH965_RS10205	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FH965_RS10220	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FH965_RS10225	COG1619	proteins homologs of microcin C7 resistance protein MccF
FH965_RS10230	COG0477	Major facilitator Superfamily
FH965_RS10235	COG0387	Pfam Sodium calcium exchanger
FH965_RS10255	COG0556	nucleotide-excision repair
FH965_RS10265	COG0584	glycerophosphoryl diester phosphodiesterase
FH965_RS10270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FH965_RS10285	COG2313	pseudouridylate synthase activity
FH965_RS10290	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FH965_RS10290	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FH965_RS10295	COG0598	Magnesium transport protein CorA
FH965_RS10360	COG2124	cytochrome p450
FH965_RS10365	COG0402	S-adenosylhomocysteine deaminase activity
FH965_RS10405	COG0251	oxidation-reduction process
FH965_RS10420	COG1288	antiporter activity
FH965_RS10455	COG0237	dephospho-CoA kinase activity
FH965_RS10470	COG0539	negative regulation of cytoplasmic translation
FH965_RS10480	COG1643	Atp-dependent helicase
FH965_RS10510	COG2050	protein possibly involved in aromatic compounds catabolism
FH965_RS10520	COG0559	Belongs to the binding-protein-dependent transport system permease family
FH965_RS10565	COG0737	Belongs to the 5'-nucleotidase family
FH965_RS10595	COG1605	Chorismate mutase
FH965_RS10595	COG0287	Prephenate dehydrogenase
FH965_RS10610	COG0366	Alpha amylase catalytic
FH965_RS10610	COG1470	cell adhesion involved in biofilm formation
FH965_RS10615	COG4585	Histidine kinase
FH965_RS10620	COG2197	response regulator
FH965_RS10635	COG0477	Major facilitator Superfamily
FH965_RS10640	COG1846	Transcriptional regulator
FH965_RS10645	COG2365	Tyrosine phosphatase family
FH965_RS10650	COG2304	oxidoreductase activity
FH965_RS10655	COG2267	carboxylic ester hydrolase activity
FH965_RS10675	COG0395	ABC-type sugar transport system, permease component
FH965_RS10680	COG1175	transmembrane transport
FH965_RS10700	COG0067	glutamate synthase
FH965_RS10700	COG0070	glutamate synthase
FH965_RS10700	COG0069	glutamate synthase activity
FH965_RS10730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FH965_RS10735	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FH965_RS10745	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FH965_RS10755	COG0159	tryptophan synthase activity
FH965_RS10760	COG0133	tryptophan synthase activity
FH965_RS10770	COG0134	indole-3-glycerol-phosphate synthase activity
FH965_RS10790	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FH965_RS10795	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FH965_RS10805	COG0107	imidazoleglycerol-phosphate synthase activity
FH965_RS10810	COG0251	oxidation-reduction process
FH965_RS10815	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FH965_RS10820	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FH965_RS10825	COG0131	Imidazoleglycerol-phosphate dehydratase
FH965_RS10830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FH965_RS10835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FH965_RS10855	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FH965_RS10875	COG1432	Conserved Protein
FH965_RS10880	COG0587	DNA-directed DNA polymerase activity
FH965_RS10920	COG2153	protein acetylation
FH965_RS10930	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FH965_RS10945	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FH965_RS10960	COG1799	cell septum assembly
FH965_RS10965	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FH965_RS10970	COG1496	oxidoreductase activity
FH965_RS10975	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FH965_RS10985	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FH965_RS10990	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FH965_RS11000	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FH965_RS11005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FH965_RS11015	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FH965_RS11020	COG0768	penicillin binding
FH965_RS11030	COG0275	rRNA processing
FH965_RS11040	COG0714	Associated with various cellular activities
FH965_RS11060	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FH965_RS11080	COG1309	transcriptional regulator
FH965_RS11105	COG0352	thiamine-phosphate diphosphorylase activity
FH965_RS11120	COG2022	thiamine diphosphate biosynthetic process
FH965_RS11120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FH965_RS11130	COG2022	thiamine diphosphate biosynthetic process
FH965_RS11135	COG0515	serine threonine protein kinase
FH965_RS11135	COG2815	serine threonine protein kinase
FH965_RS11140	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FH965_RS11145	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FH965_RS11150	COG2193	ferroxidase activity
FH965_RS11155	COG0243	molybdopterin cofactor binding
FH965_RS11160	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FH965_RS11180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FH965_RS11185	COG0205	6-phosphofructokinase activity
FH965_RS11190	COG2197	response regulator
FH965_RS11195	COG4585	Histidine kinase
FH965_RS11220	COG1940	carbohydrate kinase activity
FH965_RS11230	COG0003	Pfam Anion-transporting ATPase
FH965_RS11250	COG0438	transferase activity, transferring glycosyl groups
FH965_RS11300	COG2205	protein histidine kinase activity
FH965_RS11305	COG0745	RESPONSE REGULATOR receiver
FH965_RS11315	COG1929	Belongs to the glycerate kinase type-1 family
FH965_RS11320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FH965_RS11325	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FH965_RS11330	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FH965_RS11335	COG0723	plastoquinol--plastocyanin reductase activity
FH965_RS11340	COG2010	Cytochrome c
FH965_RS11345	COG1845	cytochrome c oxidase, subunit III
FH965_RS11355	COG1376	ErfK ybiS ycfS ynhG family protein
FH965_RS11365	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FH965_RS11370	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FH965_RS11380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FH965_RS11400	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FH965_RS11405	COG2197	response regulator
FH965_RS11410	COG4585	Histidine kinase
FH965_RS11435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FH965_RS11455	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FH965_RS11460	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FH965_RS11460	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FH965_RS11475	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FH965_RS11480	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FH965_RS11485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FH965_RS11490	COG0508	dehydrogenase complex catalyzes the overall conversion of
FH965_RS11500	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FH965_RS11545	COG0321	lipoyl(octanoyl) transferase activity
FH965_RS11550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FH965_RS11600	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FH965_RS11605	COG2205	protein histidine kinase activity
FH965_RS11610	COG0745	RESPONSE REGULATOR receiver
FH965_RS11620	COG1686	Belongs to the peptidase S11 family
FH965_RS11625	COG0583	DNA-binding transcription factor activity
FH965_RS11635	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FH965_RS11660	COG2814	Major facilitator Superfamily
FH965_RS11665	COG1959	2 iron, 2 sulfur cluster binding
FH965_RS11670	COG1120	ATPase activity
FH965_RS11675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH965_RS11700	COG0252	asparaginase activity
FH965_RS11740	COG0745	RESPONSE REGULATOR receiver
FH965_RS11750	COG2409	Drug exporters of the RND superfamily
FH965_RS11755	COG4585	Histidine kinase
FH965_RS11760	COG2197	response regulator
FH965_RS11800	COG1309	transcriptional regulator
FH965_RS11810	COG0366	Alpha amylase catalytic
FH965_RS11815	COG1609	Transcriptional regulator
FH965_RS11825	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FH965_RS11855	COG0174	glutamine synthetase
FH965_RS11860	COG1017	nitric oxide dioxygenase activity
FH965_RS11860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FH965_RS11865	COG1959	2 iron, 2 sulfur cluster binding
FH965_RS11885	COG2267	carboxylic ester hydrolase activity
FH965_RS11895	COG0531	amino acid
FH965_RS11905	COG2132	Multicopper oxidase
FH965_RS11910	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FH965_RS11910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FH965_RS11930	COG2814	Major facilitator Superfamily
FH965_RS11945	COG0477	Major facilitator Superfamily
FH965_RS11950	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FH965_RS11970	COG1994	Peptidase M50
FH965_RS12030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FH965_RS12035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH965_RS12040	COG1120	ATPase activity
FH965_RS12050	COG2837	iron assimilation
FH965_RS12055	COG0672	)-iron permease
FH965_RS12085	COG1834	amidinotransferase
FH965_RS12100	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FH965_RS12105	COG2814	Major facilitator Superfamily
FH965_RS12120	COG0384	phenazine biosynthesis protein PhzF
FH965_RS12135	COG3540	Alkaline phosphatase
FH965_RS12170	COG2197	response regulator
FH965_RS12190	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FH965_RS12235	COG0515	serine threonine protein kinase
FH965_RS12235	COG2815	serine threonine protein kinase
FH965_RS12285	COG3022	response to hydroperoxide
FH965_RS12290	COG0800	Aldolase
FH965_RS12305	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FH965_RS12310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FH965_RS12320	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS12330	COG2030	dehydratase
FH965_RS12335	COG4585	Histidine kinase
FH965_RS12345	COG2197	response regulator
FH965_RS12355	COG0183	Belongs to the thiolase family
FH965_RS12370	COG0860	N-Acetylmuramoyl-L-alanine amidase
FH965_RS12380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH965_RS12420	COG0438	transferase activity, transferring glycosyl groups
FH965_RS12425	COG1309	transcriptional regulator
FH965_RS12450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FH965_RS12455	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS12460	COG1657	PFAM Prenyltransferase squalene oxidase
FH965_RS12475	COG3845	ABC transporter
FH965_RS12495	COG0183	Belongs to the thiolase family
FH965_RS12500	COG2124	cytochrome p450
FH965_RS12520	COG4122	O-methyltransferase activity
FH965_RS12680	COG0800	Aldolase
FH965_RS12685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FH965_RS12700	COG1358	cellular component organization or biogenesis
FH965_RS12750	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FH965_RS12755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FH965_RS12765	COG0477	Major facilitator Superfamily
FH965_RS12770	COG1309	transcriptional regulator
FH965_RS12785	COG0789	Transcriptional regulator
FH965_RS12795	COG1741	Belongs to the pirin family
FH965_RS12810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FH965_RS12815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FH965_RS12820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FH965_RS12850	COG0583	DNA-binding transcription factor activity
FH965_RS12875	COG1764	response to oxidative stress
FH965_RS12880	COG2130	NADP-dependent
FH965_RS12905	COG0438	transferase activity, transferring glycosyl groups
FH965_RS12950	COG0318	PFAM AMP-dependent synthetase and ligase
FH965_RS12965	COG0477	Major facilitator Superfamily
FH965_RS12970	COG1077	Cell shape determining protein MreB Mrl
FH965_RS12990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH965_RS12995	COG1120	ATPase activity
FH965_RS13015	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FH965_RS13030	COG0515	serine threonine protein kinase
FH965_RS13035	COG1120	ATPase activity
FH965_RS13040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH965_RS13050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FH965_RS13060	COG2508	Transcriptional regulator
FH965_RS13085	COG1960	acyl-CoA dehydrogenase activity
FH965_RS13100	COG0604	alcohol dehydrogenase
FH965_RS13100	COG3321	synthase
FH965_RS13110	COG3903	Transcriptional regulator
FH965_RS13110	COG3629	intracellular signal transduction
FH965_RS13135	COG1250	3-hydroxyacyl-CoA dehydrogenase
FH965_RS13165	COG3629	intracellular signal transduction
FH965_RS13165	COG3903	Transcriptional regulator
FH965_RS13190	COG1070	Carbohydrate kinase
FH965_RS13210	COG0358	DNA primase activity
FH965_RS13220	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FH965_RS13230	COG0243	molybdopterin cofactor binding
FH965_RS13250	COG2205	protein histidine kinase activity
FH965_RS13280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FH965_RS13285	COG2146	nitrite reductase [NAD(P)H] activity
FH965_RS13285	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FH965_RS13295	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS13310	COG0531	amino acid
FH965_RS13320	COG3629	intracellular signal transduction
FH965_RS13320	COG3903	Transcriptional regulator
FH965_RS13330	COG0395	ABC-type sugar transport system, permease component
FH965_RS13355	COG0574	Belongs to the PEP-utilizing enzyme family
FH965_RS13355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FH965_RS13365	COG1940	carbohydrate kinase activity
FH965_RS13365	COG1846	Transcriptional regulator
FH965_RS13370	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
FH965_RS13390	COG0477	Major facilitator Superfamily
FH965_RS13410	COG2124	cytochrome p450
FH965_RS13425	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FH965_RS13435	COG0667	Aldo Keto reductase
FH965_RS13455	COG0423	glycine-tRNA ligase activity
FH965_RS13460	COG3443	Belongs to the bacterial solute-binding protein 9 family
FH965_RS13460	COG0803	Belongs to the bacterial solute-binding protein 9 family
FH965_RS13465	COG1121	(ABC) transporter
FH965_RS13470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FH965_RS13480	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FH965_RS13485	COG1381	Involved in DNA repair and RecF pathway recombination
FH965_RS13515	COG2226	methyltransferase
FH965_RS13530	COG3631	Ketosteroid isomerase-related protein
FH965_RS13535	COG0702	epimerase
FH965_RS13545	COG0747	negative chemotaxis
FH965_RS13560	COG4608	Belongs to the ABC transporter superfamily
FH965_RS13565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FH965_RS13570	COG2197	response regulator
FH965_RS13575	COG4585	Histidine kinase
FH965_RS13580	COG2409	Drug exporters of the RND superfamily
FH965_RS13590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FH965_RS13605	COG2723	6-phospho-beta-galactosidase activity
FH965_RS13610	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FH965_RS13630	COG2315	Protein conserved in bacteria
FH965_RS13640	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FH965_RS13650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FH965_RS13655	COG4948	Mandelate Racemase Muconate Lactonizing
FH965_RS13680	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FH965_RS13685	COG1234	tRNA 3'-trailer cleavage
FH965_RS13690	COG0537	adenosine 5'-monophosphoramidase activity
FH965_RS13695	COG4946	Tricorn protease homolog
FH965_RS13695	COG0793	Belongs to the peptidase S41A family
FH965_RS13715	COG0484	heat shock protein binding
FH965_RS13720	COG1420	regulation of RNA biosynthetic process
FH965_RS13745	COG2205	protein histidine kinase activity
FH965_RS13745	COG3437	response regulator, receiver
FH965_RS13745	COG3850	Histidine kinase
FH965_RS13745	COG4999	Histidine kinase
FH965_RS13760	COG0481	GTPase activity
FH965_RS13765	COG0268	Binds directly to 16S ribosomal RNA
FH965_RS13780	COG2353	YceI-like domain
FH965_RS13785	COG1234	tRNA 3'-trailer cleavage
FH965_RS13790	COG1555	photosystem II stabilization
FH965_RS13795	COG1307	EDD domain protein, DegV family
FH965_RS13805	COG0495	leucyl-tRNA aminoacylation
FH965_RS13835	COG0477	Major facilitator Superfamily
FH965_RS13850	COG0588	phosphoglycerate mutase activity
FH965_RS13855	COG0799	negative regulation of ribosome biogenesis
FH965_RS13865	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FH965_RS13875	COG0501	Belongs to the peptidase M48B family
FH965_RS13890	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FH965_RS13900	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FH965_RS13910	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FH965_RS13915	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FH965_RS13920	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FH965_RS13930	COG1530	ribonuclease E activity
FH965_RS13955	COG0772	Belongs to the SEDS family
FH965_RS13960	COG0768	penicillin binding
FH965_RS13975	COG1077	Cell shape determining protein MreB Mrl
FH965_RS13980	COG0105	UTP biosynthetic process
FH965_RS13990	COG0285	dihydrofolate synthase activity
FH965_RS13995	COG1077	Cell shape determining protein MreB Mrl
FH965_RS14000	COG4585	Histidine kinase
FH965_RS14030	COG0525	valine-tRNA ligase activity
FH965_RS14045	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FH965_RS14050	COG0740	serine-type endopeptidase activity
FH965_RS14055	COG0740	serine-type endopeptidase activity
FH965_RS14060	COG0544	peptidyl-prolyl cis-trans isomerase activity
FH965_RS14075	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FH965_RS14075	COG0515	serine threonine protein kinase
FH965_RS14085	COG3594	Acyltransferase
FH965_RS14095	COG1136	(ABC) transporter
FH965_RS14105	COG4552	Acetyltransferase involved in intracellular survival and related
FH965_RS14120	COG1113	amino acid transport
FH965_RS14130	COG1268	BioY protein
FH965_RS14135	COG1113	amino acid transport
FH965_RS14140	COG1113	amino acid transport
FH965_RS14145	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FH965_RS14155	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FH965_RS14245	COG0583	DNA-binding transcription factor activity
FH965_RS14250	COG2814	Major facilitator Superfamily
FH965_RS14285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FH965_RS14300	COG0583	DNA-binding transcription factor activity
FH965_RS14315	COG0697	spore germination
FH965_RS14320	COG1846	Transcriptional regulator
FH965_RS14340	COG3291	Pkd domain containing protein
FH965_RS14340	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FH965_RS14350	COG0668	transmembrane transport
FH965_RS14355	COG1846	Transcriptional regulator
FH965_RS14355	COG1940	carbohydrate kinase activity
FH965_RS14365	COG1175	transmembrane transport
FH965_RS14370	COG0395	ABC-type sugar transport system, permease component
FH965_RS14375	COG1486	melibiose metabolic process
FH965_RS14390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH965_RS14450	COG0629	single-stranded DNA binding
FH965_RS14455	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FH965_RS14480	COG1846	Transcriptional regulator
FH965_RS14490	COG1309	transcriptional regulator
FH965_RS14500	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FH965_RS14510	COG1131	(ABC) transporter
FH965_RS14515	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FH965_RS14530	COG3962	Belongs to the TPP enzyme family
FH965_RS14535	COG3718	enzyme involved in inositol metabolism
FH965_RS14545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FH965_RS14575	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FH965_RS14585	COG1129	ABC transporter
FH965_RS14595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FH965_RS14600	COG1869	D-ribose catabolic process
FH965_RS14620	COG0673	inositol 2-dehydrogenase activity
FH965_RS14635	COG0456	acetyltransferase
FH965_RS14635	COG1846	Transcriptional regulator
FH965_RS14660	COG1472	Belongs to the glycosyl hydrolase 3 family
FH965_RS14695	COG2186	Transcriptional regulator
FH965_RS14700	COG0028	Belongs to the TPP enzyme family
FH965_RS14710	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FH965_RS14730	COG1946	Acyl-CoA thioesterase
FH965_RS14740	COG1309	transcriptional regulator
FH965_RS14745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FH965_RS14760	COG1960	acyl-CoA dehydrogenase activity
FH965_RS14795	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FH965_RS14805	COG0589	response to stress
FH965_RS14820	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FH965_RS14855	COG5002	protein histidine kinase activity
FH965_RS14885	COG0406	alpha-ribazole phosphatase activity
FH965_RS14935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH965_RS14965	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FH965_RS14980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH965_RS14985	COG0765	amino acid transport
FH965_RS14990	COG0765	amino acid transport
FH965_RS14995	COG1126	abc transporter atp-binding protein
FH965_RS15020	COG4585	Histidine kinase
FH965_RS15030	COG2409	Drug exporters of the RND superfamily
FH965_RS15040	COG2197	response regulator
FH965_RS15055	COG3397	chitin binding
FH965_RS15080	COG2186	Transcriptional regulator
FH965_RS15160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FH965_RS15165	COG2188	Transcriptional regulator
FH965_RS15180	COG0673	inositol 2-dehydrogenase activity
FH965_RS15185	COG4702	Belongs to the UPF0303 family
FH965_RS15200	COG0706	membrane insertase activity
FH965_RS15220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FH965_RS15230	COG3764	Sortase (surface protein transpeptidase)
FH965_RS15310	COG2733	membrane
FH965_RS15320	COG1278	Cold shock
FH965_RS15325	COG0513	Belongs to the DEAD box helicase family
FH965_RS15370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FH965_RS15405	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FH965_RS15415	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FH965_RS15420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FH965_RS15425	COG1263	PTS System
FH965_RS15430	COG1263	PTS System
FH965_RS15435	COG1234	tRNA 3'-trailer cleavage
FH965_RS15460	COG1120	ATPase activity
FH965_RS15465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH965_RS15480	COG1113	amino acid transport
FH965_RS15490	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FH965_RS15500	COG1335	isochorismatase
FH965_RS15520	COG1714	RDD family
FH965_RS15535	COG0277	FAD linked oxidase domain protein
FH965_RS15545	COG3185	4-Hydroxyphenylpyruvate dioxygenase
FH965_RS15555	COG1174	glycine betaine transport
FH965_RS15565	COG1174	glycine betaine transport
FH965_RS15645	COG1376	ErfK ybiS ycfS ynhG family protein
FH965_RS15680	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FH965_RS15690	COG2814	Major facilitator Superfamily
FH965_RS15695	COG0583	DNA-binding transcription factor activity
FH965_RS15700	COG1678	Uncharacterized ACR, COG1678
FH965_RS15705	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FH965_RS15710	COG0776	regulation of translation
FH965_RS15720	COG3973	AAA domain
FH965_RS15750	COG2223	nitrite transmembrane transporter activity
FH965_RS15780	COG0583	DNA-binding transcription factor activity
FH965_RS15790	COG2027	D-alanyl-D-alanine carboxypeptidase
FH965_RS15800	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FH965_RS15805	COG0793	Belongs to the peptidase S41A family
FH965_RS15810	COG2177	Part of the ABC transporter FtsEX involved in
FH965_RS15815	COG2884	Cell division ATP-binding protein ftsE
FH965_RS15830	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FH965_RS15835	COG0515	serine threonine protein kinase
FH965_RS15840	COG0515	serine threonine protein kinase
FH965_RS15855	COG1175	transmembrane transport
FH965_RS15860	COG0395	ABC-type sugar transport system, permease component
FH965_RS15865	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FH965_RS15865	COG0463	Glycosyl transferase, family 2
FH965_RS15880	COG0438	transferase activity, transferring glycosyl groups
FH965_RS15910	COG1131	(ABC) transporter
FH965_RS15915	COG1131	(ABC) transporter
FH965_RS15925	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FH965_RS15930	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FH965_RS15975	COG1309	transcriptional regulator
FH965_RS15985	COG1134	teichoic acid transport
FH965_RS15985	COG1388	LysM domain
FH965_RS15990	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FH965_RS15995	COG1215	transferase activity, transferring glycosyl groups
FH965_RS16010	COG1216	Glycosyl transferase, family 2
FH965_RS16015	COG2902	Dehydrogenase
FH965_RS16040	COG0653	protein targeting
FH965_RS16050	COG3214	Protein conserved in bacteria
FH965_RS16055	COG2197	response regulator
FH965_RS16060	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FH965_RS16070	COG0823	Involved in the tonB-independent uptake of proteins
FH965_RS16075	COG5002	protein histidine kinase activity
FH965_RS16080	COG0745	RESPONSE REGULATOR receiver
FH965_RS16085	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FH965_RS16105	COG0714	Associated with various cellular activities
FH965_RS16155	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FH965_RS16160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FH965_RS16160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH965_RS16160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FH965_RS16170	COG1482	cell wall glycoprotein biosynthetic process
FH965_RS16180	COG2835	tetraacyldisaccharide 4'-kinase activity
FH965_RS16185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FH965_RS16190	COG1620	l-lactate permease
FH965_RS16225	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FH965_RS16230	COG0778	Nitroreductase
FH965_RS16230	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
FH965_RS16260	COG1316	TRANSCRIPTIONal
FH965_RS16290	COG1316	TRANSCRIPTIONal
FH965_RS16300	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FH965_RS16335	COG2205	protein histidine kinase activity
FH965_RS16340	COG0745	RESPONSE REGULATOR receiver
FH965_RS16345	COG3104	oligopeptide transport
FH965_RS16380	COG1366	Belongs to the anti-sigma-factor antagonist family
FH965_RS16385	COG1191	sigma factor activity
FH965_RS16400	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FH965_RS16405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FH965_RS16415	COG1228	amidohydrolase
FH965_RS16425	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FH965_RS16440	COG2755	lipolytic protein G-D-S-L family
FH965_RS16445	COG0183	Belongs to the thiolase family
FH965_RS16480	COG1136	(ABC) transporter
FH965_RS16485	COG0577	efflux transmembrane transporter activity
FH965_RS16490	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FH965_RS16495	COG1252	NADH dehydrogenase
FH965_RS16515	COG0148	phosphopyruvate hydratase activity
FH965_RS16530	COG2124	cytochrome p450
FH965_RS16600	COG0577	efflux transmembrane transporter activity
FH965_RS16605	COG1136	(ABC) transporter
FH965_RS16620	COG1316	TRANSCRIPTIONal
FH965_RS16645	COG4585	Histidine kinase
FH965_RS16660	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FH965_RS16665	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FH965_RS16670	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FH965_RS16675	COG0193	aminoacyl-tRNA hydrolase activity
FH965_RS16685	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FH965_RS16695	COG1309	transcriptional regulator
FH965_RS16705	COG4106	trans-aconitate 2-methyltransferase activity
FH965_RS16710	COG1846	Transcriptional regulator
FH965_RS16715	COG2197	response regulator
FH965_RS16725	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FH965_RS16765	COG0488	(ABC) transporter
FH965_RS16770	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FH965_RS16775	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FH965_RS16780	COG3584	3D domain protein
FH965_RS16780	COG3583	domain protein
FH965_RS16785	COG0084	hydrolase, TatD family'
FH965_RS16825	COG0442	prolyl-tRNA aminoacylation
FH965_RS16835	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FH965_RS16840	COG1122	ATPase activity
FH965_RS16850	COG0310	cobalt ion transport
FH965_RS16860	COG2409	Drug exporters of the RND superfamily
FH965_RS16870	COG0793	Belongs to the peptidase S41A family
FH965_RS16870	COG4946	Tricorn protease homolog
FH965_RS16880	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS16885	COG0596	Alpha beta hydrolase
FH965_RS16890	COG2072	flavoprotein involved in K transport
FH965_RS16905	COG0708	Exodeoxyribonuclease III
FH965_RS16915	COG2205	protein histidine kinase activity
FH965_RS16925	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FH965_RS16945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FH965_RS16950	COG0521	Mo-molybdopterin cofactor biosynthetic process
FH965_RS16950	COG0315	cyclic pyranopterin monophosphate synthase activity
FH965_RS16955	COG0315	cyclic pyranopterin monophosphate synthase activity
FH965_RS16965	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FH965_RS16970	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FH965_RS16975	COG2366	antibiotic biosynthetic process
FH965_RS16980	COG3263	regulation of cellular component size
FH965_RS16995	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FH965_RS17005	COG1970	mechanosensitive ion channel activity
FH965_RS17020	COG3191	aminopeptidase activity
FH965_RS17055	COG1349	DNA-binding transcription factor activity
FH965_RS17060	COG0477	Major facilitator Superfamily
FH965_RS17075	COG1247	-acetyltransferase
FH965_RS17085	COG1846	Transcriptional regulator
FH965_RS17105	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FH965_RS17120	COG1012	belongs to the aldehyde dehydrogenase family
FH965_RS17135	COG0583	DNA-binding transcription factor activity
FH965_RS17175	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FH965_RS17190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FH965_RS17205	COG1686	Belongs to the peptidase S11 family
FH965_RS17240	COG4977	sequence-specific DNA binding
FH965_RS17315	COG0702	epimerase
FH965_RS17335	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FH965_RS17345	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FH965_RS17350	COG1012	belongs to the aldehyde dehydrogenase family
FH965_RS17355	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FH965_RS17360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH965_RS17385	COG3903	Transcriptional regulator
FH965_RS17385	COG3629	intracellular signal transduction
FH965_RS17420	COG1024	Enoyl-CoA hydratase
FH965_RS17425	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FH965_RS17425	COG0515	serine threonine protein kinase
FH965_RS17435	COG1309	transcriptional regulator
FH965_RS17445	COG1960	acyl-CoA dehydrogenase activity
FH965_RS17475	COG2072	flavoprotein involved in K transport
FH965_RS17480	COG1042	CoA-binding domain protein
FH965_RS17480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FH965_RS17480	COG0045	succinate-CoA ligase (ADP-forming) activity
FH965_RS17515	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FH965_RS17525	COG1024	Enoyl-CoA hydratase
FH965_RS17535	COG1960	acyl-CoA dehydrogenase activity
FH965_RS17540	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS17560	COG1960	acyl-CoA dehydrogenase activity
FH965_RS17565	COG1960	acyl-CoA dehydrogenase activity
FH965_RS17570	COG0318	PFAM AMP-dependent synthetase and ligase
FH965_RS17580	COG1366	Belongs to the anti-sigma-factor antagonist family
FH965_RS17625	COG1131	(ABC) transporter
FH965_RS17640	COG4821	SIS domain
FH965_RS17650	COG2945	thiolester hydrolase activity
FH965_RS17650	COG0596	Alpha beta hydrolase
FH965_RS17655	COG0259	pyridoxamine-phosphate oxidase activity
FH965_RS17680	COG0439	Biotin carboxylase
FH965_RS17685	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FH965_RS17705	COG0247	lactate metabolic process
FH965_RS17705	COG0277	FAD linked oxidase domain protein
FH965_RS17710	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FH965_RS17750	COG3903	Transcriptional regulator
FH965_RS17750	COG3629	intracellular signal transduction
FH965_RS17755	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FH965_RS17770	COG1846	Transcriptional regulator
FH965_RS17780	COG2252	PERMEase
FH965_RS17790	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FH965_RS17820	COG2814	Major facilitator Superfamily
FH965_RS17830	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FH965_RS17835	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
FH965_RS17840	COG1278	Cold shock
FH965_RS17855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH965_RS17860	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH965_RS17865	COG1120	ATPase activity
FH965_RS17870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FH965_RS17890	COG1061	Type III restriction enzyme res subunit
FH965_RS17910	COG3973	AAA domain
FH965_RS17955	COG1737	Transcriptional regulator
FH965_RS17960	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FH965_RS18010	COG0463	Glycosyl transferase, family 2
FH965_RS18035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FH965_RS18045	COG0402	S-adenosylhomocysteine deaminase activity
FH965_RS18050	COG1105	Belongs to the carbohydrate kinase PfkB family
FH965_RS18075	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FH965_RS18105	COG2197	response regulator
FH965_RS18125	COG4552	Acetyltransferase involved in intracellular survival and related
FH965_RS18150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FH965_RS18160	COG3842	ATPase activity
FH965_RS18170	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FH965_RS18185	COG0215	cysteine-tRNA ligase activity
FH965_RS18190	COG3467	pyridoxamine 5'-phosphate
FH965_RS18195	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FH965_RS18200	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FH965_RS18205	COG1329	Transcriptional regulator
FH965_RS18225	COG5002	protein histidine kinase activity
FH965_RS18250	COG2814	Major facilitator Superfamily
FH965_RS18255	COG0588	phosphoglycerate mutase activity
FH965_RS18270	COG0438	transferase activity, transferring glycosyl groups
FH965_RS18305	COG2364	Membrane
FH965_RS18345	COG0583	DNA-binding transcription factor activity
FH965_RS18380	COG0546	phosphoglycolate phosphatase activity
FH965_RS18395	COG2188	Transcriptional regulator
FH965_RS18410	COG1490	D-aminoacyl-tRNA deacylase activity
FH965_RS18415	COG0354	folic acid binding
FH965_RS18425	COG3485	protocatechuate 3,4-dioxygenase
FH965_RS18445	COG2897	thiosulfate sulfurtransferase activity
FH965_RS18470	COG0745	RESPONSE REGULATOR receiver
FH965_RS18475	COG1609	Transcriptional regulator
FH965_RS18495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FH965_RS18500	COG0745	RESPONSE REGULATOR receiver
FH965_RS18510	COG0488	(ABC) transporter
FH965_RS18520	COG0737	Belongs to the 5'-nucleotidase family
FH965_RS18525	COG0456	acetyltransferase
FH965_RS18530	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FH965_RS18560	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FH965_RS18565	COG0306	phosphate transporter
FH965_RS18575	COG1937	Protein conserved in bacteria
FH965_RS18590	COG0277	FAD linked oxidase domain protein
FH965_RS18595	COG0671	phosphoesterase, PA-phosphatase related
FH965_RS18605	COG0456	acetyltransferase
FH965_RS18655	COG1131	(ABC) transporter
FH965_RS18665	COG4585	Histidine kinase
FH965_RS18670	COG2197	response regulator
FH965_RS18710	COG1252	NADH dehydrogenase
FH965_RS18740	COG0579	oxidoreductase
FH965_RS18745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FH965_RS18755	COG0667	Aldo Keto reductase
FH965_RS18780	COG1595	DNA-templated transcription, initiation
FH965_RS18800	COG1309	transcriptional regulator
FH965_RS18830	COG0513	Belongs to the DEAD box helicase family
FH965_RS18890	COG4232	protein-disulfide reductase activity
FH965_RS18895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FH965_RS18895	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FH965_RS18905	COG1643	Atp-dependent helicase
FH965_RS18940	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FH965_RS18950	COG3119	arylsulfatase activity
FH965_RS18980	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FH965_RS18985	COG0047	phosphoribosylformylglycinamidine synthase activity
FH965_RS18990	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FH965_RS19010	COG1131	(ABC) transporter
FH965_RS19035	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FH965_RS19055	COG0151	Belongs to the GarS family
FH965_RS19075	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS19080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FH965_RS19090	COG0697	spore germination
FH965_RS19095	COG0583	DNA-binding transcription factor activity
FH965_RS19105	COG0433	COG0433 Predicted ATPase
FH965_RS19120	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FH965_RS19150	COG1191	sigma factor activity
FH965_RS19155	COG1191	sigma factor activity
FH965_RS19190	COG0477	Major facilitator Superfamily
FH965_RS19195	COG0745	RESPONSE REGULATOR receiver
FH965_RS19240	COG0784	Response regulator, receiver
FH965_RS19245	COG0318	PFAM AMP-dependent synthetase and ligase
FH965_RS19250	COG1595	DNA-templated transcription, initiation
FH965_RS19290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FH965_RS19305	COG0653	protein targeting
FH965_RS19325	COG0006	proline dipeptidase activity
FH965_RS19335	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FH965_RS19355	COG2188	Transcriptional regulator
FH965_RS19390	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FH965_RS19390	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FH965_RS19420	COG0270	DNA (cytosine-5-)-methyltransferase activity
FH965_RS19570	COG0667	Aldo Keto reductase
FH965_RS19580	COG1733	regulation of RNA biosynthetic process
FH965_RS19605	COG1999	signal sequence binding
FH965_RS19620	COG2837	iron assimilation
FH965_RS19630	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FH965_RS19635	COG0561	phosphatase activity
FH965_RS19660	COG1131	(ABC) transporter
FH965_RS19680	COG0789	Transcriptional regulator
FH965_RS19685	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
FH965_RS19700	COG0561	phosphatase activity
FH965_RS19715	COG4988	ABC transporter
FH965_RS19720	COG1294	oxidase, subunit
FH965_RS19725	COG1271	oxidase subunit
FH965_RS19730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FH965_RS19735	COG1609	Transcriptional regulator
FH965_RS19750	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FH965_RS19775	COG0662	Cupin 2, conserved barrel domain protein
FH965_RS19780	COG1950	PFAM Membrane protein of
FH965_RS19785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FH965_RS19790	COG0626	cystathionine gamma-synthase activity
FH965_RS19830	COG2814	Major facilitator Superfamily
FH965_RS19850	COG1252	NADH dehydrogenase
FH965_RS19855	COG0305	Participates in initiation and elongation during chromosome replication
FH965_RS19865	COG0359	binds to the 23S rRNA
FH965_RS19870	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FH965_RS19875	COG0629	single-stranded DNA binding
FH965_RS19880	COG0360	Binds together with S18 to 16S ribosomal RNA
FH965_RS19905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FH965_RS19930	COG0617	tRNA 3'-terminal CCA addition
FH965_RS19950	COG1595	DNA-templated transcription, initiation
FH965_RS19960	COG0492	ferredoxin-NADP+ reductase activity
FH965_RS19965	COG3118	belongs to the thioredoxin family
FH965_RS19980	COG1192	Involved in chromosome partitioning
FH965_RS19985	COG0357	Ribosomal RNA small subunit methyltransferase G
FH965_RS19995	COG0706	membrane insertase activity
FH965_RS20000	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FH965_RS20005	COG0594	ribonuclease P activity
FH965_RS20010	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FH965_RS20015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FH965_RS20025	COG0592	DNA-directed DNA polymerase activity
FH965_RS20030	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FH965_RS20035	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FH965_RS20040	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
FH965_RS20050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FH965_RS20090	COG0515	serine threonine protein kinase
FH965_RS20175	COG0438	transferase activity, transferring glycosyl groups
FH965_RS20195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FH965_RS20200	COG0297	glycogen (starch) synthase activity
FH965_RS20295	COG0457	Tetratricopeptide repeat
FH965_RS20295	COG0705	Rhomboid family
FH965_RS20310	COG3764	Sortase (surface protein transpeptidase)
FH965_RS20325	COG3764	Sortase (surface protein transpeptidase)
FH965_RS20330	COG3764	Sortase (surface protein transpeptidase)
FH965_RS20335	COG0515	serine threonine protein kinase
FH965_RS20340	COG0768	penicillin binding
FH965_RS20355	COG1716	ATPase activity
FH965_RS20360	COG1716	ATPase activity
FH965_RS20390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FH965_RS20395	COG2151	metal-sulfur cluster biosynthetic enzyme
FH965_RS20400	COG3396	Phenylacetate-CoA oxygenase
FH965_RS20405	COG3460	Phenylacetate-CoA oxygenase
FH965_RS20410	COG3396	Phenylacetate-CoA oxygenase
FH965_RS20435	COG1250	3-hydroxyacyl-CoA dehydrogenase
FH965_RS20440	COG1309	transcriptional regulator
FH965_RS20445	COG1522	sequence-specific DNA binding
FH965_RS20475	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FH965_RS20500	COG0515	serine threonine protein kinase
FH965_RS20505	COG0515	serine threonine protein kinase
FH965_RS20525	COG0022	dehydrogenase e1 component
FH965_RS20530	COG0508	dehydrogenase complex catalyzes the overall conversion of
FH965_RS20540	COG1802	Transcriptional regulator
FH965_RS20545	COG2271	Major facilitator Superfamily
FH965_RS20565	COG1362	aminopeptidase activity
FH965_RS20570	COG1960	acyl-CoA dehydrogenase activity
FH965_RS20590	COG1741	Belongs to the pirin family
FH965_RS20605	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FH965_RS20625	COG1309	transcriptional regulator
FH965_RS20630	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FH965_RS20635	COG2304	oxidoreductase activity
FH965_RS20650	COG0583	DNA-binding transcription factor activity
FH965_RS20660	COG1289	transmembrane transporter activity
FH965_RS20695	COG0583	DNA-binding transcription factor activity
FH965_RS20710	COG0477	Major facilitator Superfamily
FH965_RS20720	COG1051	belongs to the nudix hydrolase family
FH965_RS20750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH965_RS20760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FH965_RS20810	COG1982	Orn Lys Arg decarboxylase major
FH965_RS20815	COG1136	(ABC) transporter
FH965_RS20815	COG0577	efflux transmembrane transporter activity
FH965_RS20820	COG1136	(ABC) transporter
FH965_RS20820	COG0577	efflux transmembrane transporter activity
FH965_RS20830	COG0745	RESPONSE REGULATOR receiver
FH965_RS20835	COG2205	protein histidine kinase activity
FH965_RS20885	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS20910	COG0513	Belongs to the DEAD box helicase family
FH965_RS20915	COG1278	Cold shock
FH965_RS20925	COG0717	Belongs to the dCTP deaminase family
FH965_RS20985	COG0247	lactate metabolic process
FH965_RS20985	COG2181	nitrate reductase activity
FH965_RS20990	COG0443	Heat shock 70 kDa protein
FH965_RS20995	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FH965_RS21000	COG0484	heat shock protein binding
FH965_RS21005	COG0789	Transcriptional regulator
FH965_RS21060	COG0542	response to heat
FH965_RS21090	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FH965_RS21105	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FH965_RS21110	COG0191	fructose-bisphosphate aldolase activity
FH965_RS21115	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FH965_RS21125	COG3844	kynureninase activity
FH965_RS21150	COG2124	cytochrome p450
FH965_RS21155	COG2197	response regulator
FH965_RS21160	COG4585	Histidine kinase
FH965_RS21170	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FH965_RS21175	COG4249	Peptidase C14 caspase catalytic subunit p20
FH965_RS21175	COG2319	Wd-40 repeat
FH965_RS21180	COG0515	serine threonine protein kinase
FH965_RS21180	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FH965_RS21220	COG0693	protein deglycase activity
FH965_RS21240	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FH965_RS21245	COG1802	Transcriptional regulator
FH965_RS21250	COG0463	Glycosyl transferase, family 2
FH965_RS21265	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FH965_RS21270	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FH965_RS21300	COG1595	DNA-templated transcription, initiation
FH965_RS21355	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
FH965_RS21375	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FH965_RS21415	COG4249	Peptidase C14 caspase catalytic subunit p20
FH965_RS21415	COG2319	Wd-40 repeat
FH965_RS21435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FH965_RS21440	COG0151	Belongs to the GarS family
FH965_RS21450	COG1113	amino acid transport
FH965_RS21500	COG1408	metallophosphoesterase
FH965_RS21525	COG0003	Pfam Anion-transporting ATPase
FH965_RS21550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FH965_RS21585	COG0596	Alpha beta hydrolase
FH965_RS21595	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FH965_RS21600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FH965_RS21665	COG1205	dead DEAH box helicase
FH965_RS21665	COG1111	helicase
FH965_RS21670	COG1366	Belongs to the anti-sigma-factor antagonist family
FH965_RS21680	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FH965_RS21700	COG2890	protein-(glutamine-N5) methyltransferase activity
FH965_RS21715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FH965_RS21715	COG1754	DNA topoisomerase type I activity
FH965_RS21720	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FH965_RS21725	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FH965_RS21775	COG2197	response regulator
FH965_RS21785	COG0596	Alpha beta hydrolase
FH965_RS21790	COG3629	intracellular signal transduction
FH965_RS21790	COG3903	Transcriptional regulator
FH965_RS21800	COG0745	RESPONSE REGULATOR receiver
FH965_RS21805	COG2205	protein histidine kinase activity
FH965_RS21810	COG3903	Transcriptional regulator
FH965_RS21810	COG3629	intracellular signal transduction
FH965_RS21815	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FH965_RS21815	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FH965_RS21820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FH965_RS21820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FH965_RS21835	COG0789	Transcriptional regulator
FH965_RS21850	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FH965_RS21855	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FH965_RS21860	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FH965_RS21865	COG0254	rRNA binding
FH965_RS21875	COG0640	Transcriptional regulator
FH965_RS21895	COG1012	belongs to the aldehyde dehydrogenase family
FH965_RS21900	COG2318	DinB family
FH965_RS21920	COG0076	glutamate decarboxylase activity
FH965_RS21925	COG0789	Transcriptional regulator
FH965_RS21930	COG0586	Pfam SNARE associated Golgi protein
FH965_RS21940	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FH965_RS21945	COG2027	D-alanyl-D-alanine carboxypeptidase
FH965_RS21955	COG0037	tRNA processing
FH965_RS21970	COG0302	gtp cyclohydrolase
FH965_RS21985	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FH965_RS22005	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FH965_RS22005	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FH965_RS22020	COG1174	glycine betaine transport
FH965_RS22025	COG1174	glycine betaine transport
FH965_RS22050	COG0649	NAD binding
FH965_RS22065	COG2197	response regulator
FH965_RS22090	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FH965_RS22095	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FH965_RS22105	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FH965_RS22130	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FH965_RS22170	COG0739	heme binding
FH965_RS22180	COG0477	Major facilitator Superfamily
FH965_RS22190	COG0346	lactoylglutathione lyase activity
FH965_RS22195	COG2205	protein histidine kinase activity
FH965_RS22200	COG0745	RESPONSE REGULATOR receiver
FH965_RS22210	COG1595	DNA-templated transcription, initiation
FH965_RS22215	COG1194	a g-specific adenine glycosylase
FH965_RS22220	COG4585	Histidine kinase
FH965_RS22240	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
FH965_RS22260	COG0248	Ppx GppA phosphatase
FH965_RS22265	COG1082	Xylose isomerase domain protein TIM barrel
FH965_RS22275	COG0129	dihydroxy-acid dehydratase activity
FH965_RS22280	COG4991	sh3 domain protein
FH965_RS22295	COG1129	ABC transporter
FH965_RS22295	COG0842	Transport permease protein
FH965_RS22305	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FH965_RS22320	COG0180	Tryptophanyl-tRNA synthetase
FH965_RS22345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FH965_RS22355	COG0123	including yeast histone deacetylase and acetoin utilization protein
FH965_RS22405	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FH965_RS22410	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FH965_RS22415	COG0181	hydroxymethylbilane synthase activity
FH965_RS22420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FH965_RS22420	COG1648	precorrin-2 dehydrogenase activity
FH965_RS22425	COG0113	porphobilinogen synthase activity
FH965_RS22430	COG0604	alcohol dehydrogenase
FH965_RS22430	COG3321	synthase
FH965_RS22455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FH965_RS22460	COG0018	arginyl-trna synthetase
FH965_RS22465	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
FH965_RS22490	COG1690	Belongs to the RtcB family
FH965_RS22510	COG1742	UPF0060 membrane protein
FH965_RS22560	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FH965_RS22565	COG0406	alpha-ribazole phosphatase activity
FH965_RS22575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FH965_RS22580	COG0785	Cytochrome C biogenesis protein
FH965_RS22585	COG1333	cytochrome c biogenesis protein
FH965_RS22590	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FH965_RS22620	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FH965_RS22625	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FH965_RS22630	COG0163	prenyltransferase activity
FH965_RS22640	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FH965_RS22650	COG1301	dicarboxylic acid transport
FH965_RS22655	COG1309	transcriptional regulator
FH965_RS22740	COG0747	negative chemotaxis
FH965_RS22750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FH965_RS22760	COG4608	Belongs to the ABC transporter superfamily
FH965_RS22765	COG1278	Cold shock
FH965_RS22770	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
FH965_RS22780	COG0515	serine threonine protein kinase
FH965_RS22780	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FH965_RS22785	COG1674	ftsk spoiiie
FH965_RS22850	COG1660	Displays ATPase and GTPase activities
FH965_RS22855	COG2318	DinB family
FH965_RS22925	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FH965_RS22935	COG2226	methyltransferase
FH965_RS22970	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FH965_RS22975	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FH965_RS22980	COG0649	NAD binding
FH965_RS22990	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FH965_RS22995	COG1034	ATP synthesis coupled electron transport
FH965_RS23000	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FH965_RS23005	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FH965_RS23010	COG0839	Belongs to the complex I subunit 6 family
FH965_RS23015	COG0713	ATP synthesis coupled electron transport
FH965_RS23020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FH965_RS23030	COG1007	ATP synthesis coupled electron transport
FH965_RS23065	COG0561	phosphatase activity
FH965_RS23070	COG0142	geranyltranstransferase activity
FH965_RS23125	COG0662	Cupin 2, conserved barrel domain protein
FH965_RS23135	COG1733	regulation of RNA biosynthetic process
FH965_RS23150	COG0702	epimerase
FH965_RS23160	COG0702	epimerase
FH965_RS23165	COG1733	regulation of RNA biosynthetic process
FH965_RS23170	COG1013	pyruvate-flavodoxin oxidoreductase activity
FH965_RS23175	COG0674	pyruvate-flavodoxin oxidoreductase activity
FH965_RS23175	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FH965_RS23195	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FH965_RS23200	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FH965_RS23205	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FH965_RS23210	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FH965_RS23215	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FH965_RS23220	COG0839	Belongs to the complex I subunit 6 family
FH965_RS23225	COG0713	ATP synthesis coupled electron transport
FH965_RS23230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FH965_RS23240	COG1007	ATP synthesis coupled electron transport
FH965_RS23245	COG0501	Belongs to the peptidase M48B family
FH965_RS23250	COG3304	Inner membrane component domain
FH965_RS23260	COG2261	transglycosylase associated protein
FH965_RS23330	COG1666	GTP binding
FH965_RS23350	COG0702	epimerase
FH965_RS23370	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FH965_RS23375	COG2030	dehydratase
FH965_RS23390	COG0477	Major facilitator Superfamily
FH965_RS23395	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FH965_RS23410	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FH965_RS23415	COG0436	Aminotransferase
FH965_RS23425	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FH965_RS23430	COG0250	Participates in transcription elongation, termination and antitermination
FH965_RS23440	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FH965_RS23445	COG0081	regulation of translation
FH965_RS23460	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FH965_RS23465	COG0222	ribosome binding
FH965_RS23475	COG0085	RNA polymerase activity
FH965_RS23480	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FH965_RS23490	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FH965_RS23495	COG0049	tRNA binding
FH965_RS23500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FH965_RS23505	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FH965_RS23510	COG0051	transcription antitermination factor activity, RNA binding
FH965_RS23515	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FH965_RS23520	COG0088	Forms part of the polypeptide exit tunnel
FH965_RS23525	COG0089	rRNA binding
FH965_RS23530	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FH965_RS23535	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FH965_RS23540	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FH965_RS23545	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FH965_RS23550	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FH965_RS23555	COG0255	Belongs to the universal ribosomal protein uL29 family
FH965_RS23560	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FH965_RS23565	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FH965_RS23570	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FH965_RS23575	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FH965_RS23580	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FH965_RS23590	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FH965_RS23595	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FH965_RS23600	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FH965_RS23605	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FH965_RS23610	COG1841	ribosomal large subunit assembly
FH965_RS23615	COG0200	Binds to the 23S rRNA
FH965_RS23625	COG0563	adenylate kinase activity
FH965_RS23635	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FH965_RS23640	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FH965_RS23645	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FH965_RS23650	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FH965_RS23655	COG0202	RNA polymerase activity
FH965_RS23660	COG0203	ribosomal protein L17
FH965_RS23665	COG0101	tRNA pseudouridine synthase activity
FH965_RS23680	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FH965_RS23685	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FH965_RS23690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FH965_RS23700	COG1072	(Pantothenic acid kinase))
FH965_RS23705	COG0736	holo-[acyl-carrier-protein] synthase activity
FH965_RS23715	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FH965_RS23725	COG0802	atpase or kinase
FH965_RS23750	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FH965_RS23775	COG0726	polysaccharide deacetylase
FH965_RS23785	COG0459	protein refolding
FH965_RS23790	COG4221	oxidoreductase activity
FH965_RS23800	COG0583	DNA-binding transcription factor activity
FH965_RS23815	COG1595	DNA-templated transcription, initiation
FH965_RS23825	COG0516	GMP reductase activity
FH965_RS23840	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FH965_RS23855	COG0515	serine threonine protein kinase
FH965_RS23860	COG0515	serine threonine protein kinase
FH965_RS23865	COG0515	serine threonine protein kinase
FH965_RS23870	COG0515	serine threonine protein kinase
FH965_RS23875	COG1012	belongs to the aldehyde dehydrogenase family
FH965_RS23905	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FH965_RS23905	COG0519	Catalyzes the synthesis of GMP from XMP
FH965_RS23945	COG2197	response regulator
FH965_RS23980	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FH965_RS23995	COG0714	Associated with various cellular activities
FH965_RS24005	COG3552	Protein containing von Willebrand factor type A (VWA) domain
FH965_RS24010	COG0045	succinate-CoA ligase (ADP-forming) activity
FH965_RS24035	COG0138	bifunctional purine biosynthesis protein purh
FH965_RS24040	COG1714	RDD family
FH965_RS24045	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FH965_RS24055	COG4585	Histidine kinase
FH965_RS24060	COG2197	response regulator
FH965_RS24095	COG0039	L-malate dehydrogenase activity
FH965_RS24115	COG0477	Major facilitator Superfamily
FH965_RS24135	COG1476	TRANSCRIPTIONal
FH965_RS24150	COG1012	belongs to the aldehyde dehydrogenase family
FH965_RS24160	COG0517	IMP dehydrogenase activity
FH965_RS24160	COG4175	Glycine betaine
FH965_RS24165	COG4176	ABC-type proline glycine betaine transport system permease component
FH965_RS24180	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FH965_RS24185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FH965_RS24195	COG1959	2 iron, 2 sulfur cluster binding
FH965_RS24285	COG2249	NAD(P)H dehydrogenase (quinone) activity
FH965_RS24290	COG2130	NADP-dependent
FH965_RS24300	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FH965_RS24305	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FH965_RS24320	COG1595	DNA-templated transcription, initiation
FH965_RS24325	COG0180	Tryptophanyl-tRNA synthetase
FH965_RS24360	COG1295	ribonuclease BN
FH965_RS24365	COG1686	Belongs to the peptidase S11 family
FH965_RS24375	COG1408	metallophosphoesterase
FH965_RS24380	COG2205	protein histidine kinase activity
FH965_RS24385	COG0745	RESPONSE REGULATOR receiver
FH965_RS24420	COG1053	succinate dehydrogenase
FH965_RS24430	COG2009	succinate dehydrogenase
FH965_RS24465	COG1595	DNA-templated transcription, initiation
FH965_RS24500	COG1216	Glycosyl transferase, family 2
FH965_RS24515	COG2089	acid synthase
FH965_RS24525	COG1473	amidohydrolase
FH965_RS24525	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FH965_RS24530	COG1744	ABC transporter substrate-binding protein PnrA-like
FH965_RS24535	COG1744	ABC transporter substrate-binding protein PnrA-like
FH965_RS24540	COG3845	ABC transporter
FH965_RS24545	COG4603	Belongs to the binding-protein-dependent transport system permease family
FH965_RS24550	COG1079	Belongs to the binding-protein-dependent transport system permease family
FH965_RS24575	COG2814	Major facilitator Superfamily
FH965_RS24580	COG0583	DNA-binding transcription factor activity
FH965_RS24595	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FH965_RS24620	COG2205	protein histidine kinase activity
FH965_RS24625	COG0745	RESPONSE REGULATOR receiver
FH965_RS24630	COG1595	DNA-templated transcription, initiation
FH965_RS24645	COG1012	belongs to the aldehyde dehydrogenase family
FH965_RS24650	COG1012	belongs to the aldehyde dehydrogenase family
FH965_RS24675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FH965_RS24705	COG4770	biotin carboxylase activity
FH965_RS24715	COG0424	maF-like protein
FH965_RS24730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FH965_RS24740	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FH965_RS24745	COG1024	Enoyl-CoA hydratase
FH965_RS24755	COG2986	histidine ammonia-lyase
FH965_RS24760	COG0531	amino acid
FH965_RS24780	COG1404	Belongs to the peptidase S8 family
FH965_RS24805	COG1064	alcohol dehydrogenase
FH965_RS24820	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FH965_RS24840	COG1595	DNA-templated transcription, initiation
FH965_RS24845	COG2255	four-way junction helicase activity
FH965_RS24850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FH965_RS24865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FH965_RS24875	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FH965_RS24905	COG1331	Highly conserved protein containing a thioredoxin domain
FH965_RS24920	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
FH965_RS24940	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FH965_RS24960	COG1414	Transcriptional regulator
FH965_RS24965	COG0251	oxidation-reduction process
FH965_RS24970	COG2610	gluconate transmembrane transporter activity
FH965_RS25025	COG2894	cell division
FH965_RS25065	COG2885	chlorophyll binding
FH965_RS25120	COG1674	ftsk spoiiie
FH965_RS25135	COG1733	regulation of RNA biosynthetic process
FH965_RS25145	COG0667	Aldo Keto reductase
FH965_RS25150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FH965_RS25155	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FH965_RS25170	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FH965_RS25175	COG0450	alkyl hydroperoxide reductase
FH965_RS25190	COG1136	(ABC) transporter
FH965_RS25200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FH965_RS25215	COG2226	methyltransferase
FH965_RS25225	COG0114	fumarate hydratase activity
FH965_RS25235	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FH965_RS25235	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FH965_RS25260	COG0778	Nitroreductase
FH965_RS25265	COG1722	exodeoxyribonuclease VII activity
FH965_RS25270	COG1570	exodeoxyribonuclease VII activity
FH965_RS25280	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FH965_RS25295	COG0012	GTP binding
FH965_RS25320	COG0778	Nitroreductase
FH965_RS25370	COG1842	Phage shock protein A
FH965_RS25410	COG1217	gtp-binding protein TYPA
FH965_RS25415	COG0747	negative chemotaxis
FH965_RS25420	COG0601	transmembrane transport
FH965_RS25425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FH965_RS25435	COG4608	Belongs to the ABC transporter superfamily
FH965_RS25450	COG0601	transmembrane transport
FH965_RS25455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FH965_RS25460	COG0444	Belongs to the ABC transporter superfamily
FH965_RS25465	COG4608	Belongs to the ABC transporter superfamily
FH965_RS25480	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FH965_RS25500	COG1131	(ABC) transporter
FH965_RS25510	COG4585	Histidine kinase
FH965_RS25515	COG2197	response regulator
FH965_RS25555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FH965_RS25560	COG1611	Belongs to the LOG family
FH965_RS25565	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FH965_RS25575	COG0519	Catalyzes the synthesis of GMP from XMP
FH965_RS25580	COG1024	Enoyl-CoA hydratase
FH965_RS25595	COG1595	DNA-templated transcription, initiation
FH965_RS25605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FH965_RS25610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FH965_RS25645	COG0598	Magnesium transport protein CorA
FH965_RS25670	COG2095	MarC family integral membrane protein
FH965_RS25675	COG1432	Conserved Protein
FH965_RS25680	COG0596	Alpha beta hydrolase
FH965_RS25730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FH965_RS25735	COG0601	transmembrane transport
FH965_RS25805	COG0210	DNA helicase
FH965_RS25810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FH965_RS25850	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FH965_RS25905	COG3480	Lon protease (S16) C-terminal proteolytic domain
FH965_RS25915	COG1615	UPF0182 protein
FH965_RS25940	COG0753	catalase activity
FH965_RS25950	COG0483	inositol monophosphate 1-phosphatase activity
FH965_RS25960	COG2076	Multidrug Resistance protein
FH965_RS25970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FH965_RS25980	COG2135	peptidase activity
FH965_RS25990	COG1595	DNA-templated transcription, initiation
FH965_RS25995	COG5662	AntiSigma factor
FH965_RS26000	COG2199	diguanylate cyclase activity
FH965_RS26000	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FH965_RS26015	COG0242	peptide deformylase activity
FH965_RS26025	COG2124	cytochrome p450
FH965_RS26030	COG4977	sequence-specific DNA binding
FH965_RS26075	COG1966	Carbon starvation protein
FH965_RS26080	COG2188	Transcriptional regulator
FH965_RS26085	COG2182	Extracellular solute-binding protein
FH965_RS26090	COG1175	transmembrane transport
FH965_RS26095	COG0395	ABC-type sugar transport system, permease component
FH965_RS26100	COG1472	Belongs to the glycosyl hydrolase 3 family
FH965_RS26105	COG0363	glucosamine-6-phosphate deaminase activity
FH965_RS26110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FH965_RS26115	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS26120	COG1309	transcriptional regulator
FH965_RS26135	COG1597	lipid kinase activity
FH965_RS26150	COG2172	sigma factor antagonist activity
FH965_RS26180	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FH965_RS26185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FH965_RS26190	COG0142	geranyltranstransferase activity
FH965_RS26220	COG5006	permease, DMT superfamily
FH965_RS26225	COG1011	Hydrolase
FH965_RS26230	COG1595	DNA-templated transcription, initiation
FH965_RS26255	COG4106	trans-aconitate 2-methyltransferase activity
FH965_RS26260	COG1126	abc transporter atp-binding protein
FH965_RS26280	COG0604	alcohol dehydrogenase
FH965_RS26335	COG0508	dehydrogenase complex catalyzes the overall conversion of
FH965_RS26335	COG0567	Dehydrogenase, E1 component
FH965_RS26340	COG2205	protein histidine kinase activity
FH965_RS26345	COG0745	RESPONSE REGULATOR receiver
FH965_RS26375	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FH965_RS26450	COG0768	penicillin binding
FH965_RS26465	COG2205	protein histidine kinase activity
FH965_RS26490	COG3285	dna ligase
FH965_RS26490	COG1793	dna ligase
FH965_RS26495	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FH965_RS26500	COG2267	carboxylic ester hydrolase activity
FH965_RS26520	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FH965_RS26530	COG2272	Belongs to the type-B carboxylesterase lipase family
FH965_RS26550	COG0745	RESPONSE REGULATOR receiver
FH965_RS26555	COG0018	arginyl-trna synthetase
FH965_RS26560	COG0019	diaminopimelate decarboxylase activity
FH965_RS26565	COG0460	homoserine dehydrogenase
FH965_RS26570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FH965_RS26575	COG0083	homoserine kinase activity
FH965_RS26590	COG0254	rRNA binding
FH965_RS26595	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FH965_RS26600	COG2890	protein-(glutamine-N5) methyltransferase activity
FH965_RS26610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FH965_RS26615	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FH965_RS26635	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FH965_RS26640	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FH965_RS26645	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FH965_RS26650	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FH965_RS26655	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FH965_RS26660	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FH965_RS26665	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FH965_RS26675	COG2197	response regulator
FH965_RS26680	COG4585	Histidine kinase
FH965_RS26685	COG2409	Drug exporters of the RND superfamily
FH965_RS26695	COG2197	response regulator
FH965_RS26700	COG4585	Histidine kinase
FH965_RS26730	COG1250	3-hydroxyacyl-CoA dehydrogenase
FH965_RS26745	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
FH965_RS26800	COG0183	Belongs to the thiolase family
FH965_RS26815	COG0745	RESPONSE REGULATOR receiver
FH965_RS26820	COG2205	protein histidine kinase activity
FH965_RS26865	COG1309	transcriptional regulator
FH965_RS26870	COG3629	intracellular signal transduction
FH965_RS26870	COG3903	Transcriptional regulator
FH965_RS26920	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FH965_RS26920	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FH965_RS26930	COG0745	RESPONSE REGULATOR receiver
FH965_RS26935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FH965_RS26940	COG1088	dTDP-glucose 4,6-dehydratase activity
FH965_RS26975	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FH965_RS26980	COG0280	phosphate acetyltransferase
FH965_RS26980	COG0857	belongs to the CobB CobQ family
FH965_RS26985	COG0205	6-phosphofructokinase activity
FH965_RS26995	COG0395	ABC-type sugar transport system, permease component
FH965_RS27000	COG1175	transmembrane transport
FH965_RS27010	COG4565	transcriptional regulatory protein
FH965_RS27015	COG3290	protein histidine kinase activity
FH965_RS27020	COG1301	dicarboxylic acid transport
FH965_RS27045	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FH965_RS27055	COG0477	Major facilitator Superfamily
FH965_RS27070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FH965_RS27110	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FH965_RS27115	COG3281	Trehalose synthase
FH965_RS27125	COG0366	Alpha amylase catalytic
FH965_RS27150	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FH965_RS27150	COG0515	serine threonine protein kinase
FH965_RS27160	COG0058	SHG alpha-glucan phosphorylase activity
FH965_RS27175	COG1132	(ABC) transporter
FH965_RS27180	COG1132	(ABC) transporter
FH965_RS27195	COG0583	DNA-binding transcription factor activity
FH965_RS27205	COG1376	ErfK ybiS ycfS ynhG family protein
FH965_RS27245	COG1902	pentaerythritol trinitrate reductase activity
FH965_RS27255	COG0583	DNA-binding transcription factor activity
FH965_RS27280	COG1760	l-serine dehydratase
FH965_RS27285	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FH965_RS27290	COG0509	glycine decarboxylation via glycine cleavage system
FH965_RS27295	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FH965_RS27315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FH965_RS27320	COG0747	negative chemotaxis
FH965_RS27325	COG0601	transmembrane transport
FH965_RS27330	COG0444	Belongs to the ABC transporter superfamily
FH965_RS27335	COG4608	Belongs to the ABC transporter superfamily
FH965_RS27340	COG2860	membrane
FH965_RS27350	COG2855	membrane
FH965_RS27360	COG0583	DNA-binding transcription factor activity
FH965_RS27365	COG2378	regulation of single-species biofilm formation
FH965_RS27375	COG1309	transcriptional regulator
FH965_RS27395	COG0482	sulfurtransferase activity
FH965_RS27415	COG4977	sequence-specific DNA binding
FH965_RS27430	COG4221	oxidoreductase activity
FH965_RS27440	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FH965_RS27460	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FH965_RS27465	COG0154	amidase activity
FH965_RS27475	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FH965_RS27485	COG2409	Drug exporters of the RND superfamily
FH965_RS27490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FH965_RS27505	COG2197	response regulator
FH965_RS27515	COG2133	pyrroloquinoline quinone binding
FH965_RS27520	COG0667	Aldo Keto reductase
FH965_RS27550	COG0440	acetolactate synthase activity
FH965_RS27555	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FH965_RS27560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FH965_RS27565	COG0477	Major facilitator Superfamily
FH965_RS27580	COG0506	proline dehydrogenase activity
FH965_RS27585	COG1012	belongs to the aldehyde dehydrogenase family
FH965_RS27595	COG1902	pentaerythritol trinitrate reductase activity
FH965_RS27610	COG0575	Belongs to the CDS family
FH965_RS27625	COG2130	NADP-dependent
FH965_RS27630	COG0583	DNA-binding transcription factor activity
FH965_RS27640	COG0473	3-isopropylmalate dehydrogenase activity
FH965_RS27645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FH965_RS27650	COG1309	transcriptional regulator
FH965_RS27655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FH965_RS27665	COG0832	Belongs to the urease beta subunit family
FH965_RS27665	COG0831	urea catabolic process
FH965_RS27670	COG0804	urea catabolic process
FH965_RS27675	COG2957	Belongs to the agmatine deiminase family
FH965_RS27705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FH965_RS27715	COG2353	YceI-like domain
FH965_RS27730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FH965_RS27750	COG2018	Roadblock/LC7 domain
FH965_RS27770	COG2018	Roadblock/LC7 domain
FH965_RS27775	COG5002	protein histidine kinase activity
FH965_RS27780	COG0179	Fumarylacetoacetate (FAA) hydrolase
FH965_RS27785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FH965_RS27830	COG1414	Transcriptional regulator
FH965_RS27835	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FH965_RS27840	COG0066	3-isopropylmalate dehydratase activity
FH965_RS27850	COG0776	regulation of translation
FH965_RS27860	COG1920	GTP binding
FH965_RS27870	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FH965_RS27875	COG1181	Belongs to the D-alanine--D-alanine ligase family
FH965_RS27895	COG0351	phosphomethylpyrimidine kinase
FH965_RS27910	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FH965_RS27915	COG1461	Dihydroxyacetone kinase
FH965_RS27925	COG0742	ribosomal rna small subunit methyltransferase
FH965_RS27930	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FH965_RS27945	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FH965_RS27950	COG0571	ribonuclease III activity
FH965_RS27955	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FH965_RS27960	COG1733	regulation of RNA biosynthetic process
FH965_RS27970	COG2340	Cysteine-rich secretory protein family
FH965_RS27975	COG1254	Belongs to the acylphosphatase family
FH965_RS27990	COG1196	nuclear chromosome segregation
FH965_RS27995	COG0477	Major facilitator Superfamily
FH965_RS28005	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FH965_RS28035	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FH965_RS28045	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FH965_RS28055	COG0442	prolyl-tRNA aminoacylation
FH965_RS28065	COG0228	four-way junction DNA binding
FH965_RS28070	COG1837	Belongs to the UPF0109 family
FH965_RS28075	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FH965_RS28080	COG0336	Belongs to the RNA methyltransferase TrmD family
FH965_RS28085	COG0335	large ribosomal subunit rRNA binding
FH965_RS28095	COG0681	Belongs to the peptidase S26 family
FH965_RS28100	COG0681	Belongs to the peptidase S26 family
FH965_RS28120	COG0792	nuclease activity
FH965_RS28135	COG1191	sigma factor activity
FH965_RS28150	COG0052	Belongs to the universal ribosomal protein uS2 family
FH965_RS28155	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FH965_RS28160	COG0528	UMP kinase activity
FH965_RS28165	COG0233	cytoplasmic translational termination
FH965_RS28170	COG0575	Belongs to the CDS family
FH965_RS28175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FH965_RS28190	COG3842	ATPase activity
FH965_RS28215	COG1136	(ABC) transporter
FH965_RS28220	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FH965_RS28230	COG1012	belongs to the aldehyde dehydrogenase family
FH965_RS28240	COG1309	transcriptional regulator
FH965_RS28245	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS28250	COG1733	regulation of RNA biosynthetic process
FH965_RS28270	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FH965_RS28280	COG1012	belongs to the aldehyde dehydrogenase family
FH965_RS28290	COG3842	ATPase activity
FH965_RS28295	COG1176	ABC-type spermidine putrescine transport system, permease component I
FH965_RS28305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FH965_RS28340	COG1012	belongs to the aldehyde dehydrogenase family
FH965_RS28350	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FH965_RS28355	COG0750	zinc metalloprotease
FH965_RS28360	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FH965_RS28380	COG0442	prolyl-tRNA aminoacylation
FH965_RS28400	COG0779	Required for maturation of 30S ribosomal subunits
FH965_RS28415	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FH965_RS28425	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FH965_RS28430	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FH965_RS28455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FH965_RS28460	COG0601	transmembrane transport
FH965_RS28465	COG0747	negative chemotaxis
FH965_RS28470	COG0455	bacterial-type flagellum organization
FH965_RS28490	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FH965_RS28495	COG1185	polyribonucleotide nucleotidyltransferase activity
FH965_RS28500	COG0612	Peptidase, M16
FH965_RS28505	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FH965_RS28525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FH965_RS28530	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FH965_RS28570	COG2208	phosphoserine phosphatase activity
FH965_RS28570	COG2770	Histidine kinase
FH965_RS28580	COG2205	protein histidine kinase activity
FH965_RS28580	COG3437	response regulator, receiver
FH965_RS28580	COG3850	Histidine kinase
FH965_RS28580	COG4999	Histidine kinase
FH965_RS28590	COG1674	ftsk spoiiie
FH965_RS28600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FH965_RS28610	COG1058	Belongs to the CinA family
FH965_RS28610	COG1546	Belongs to the CinA family
FH965_RS28615	COG1396	sequence-specific DNA binding
FH965_RS28620	COG0783	Belongs to the Dps family
FH965_RS28630	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS28635	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FH965_RS28640	COG1201	RNA secondary structure unwinding
FH965_RS28670	COG0628	permease
FH965_RS28675	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FH965_RS28710	COG0765	amino acid transport
FH965_RS28715	COG0765	amino acid transport
FH965_RS28720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH965_RS28725	COG1126	abc transporter atp-binding protein
FH965_RS28730	COG0745	RESPONSE REGULATOR receiver
FH965_RS28735	COG2205	protein histidine kinase activity
FH965_RS28760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FH965_RS28780	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FH965_RS28790	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FH965_RS28795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FH965_RS28805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FH965_RS28850	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FH965_RS28855	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FH965_RS28860	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FH965_RS28885	COG0488	(ABC) transporter
FH965_RS28890	COG0588	phosphoglycerate mutase activity
FH965_RS28910	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FH965_RS28945	COG1126	abc transporter atp-binding protein
FH965_RS28950	COG1802	Transcriptional regulator
FH965_RS28955	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FH965_RS28970	COG0187	DNA topoisomerase II activity
FH965_RS28980	COG4585	Histidine kinase
FH965_RS28985	COG2197	response regulator
FH965_RS28995	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FH965_RS29000	COG4565	transcriptional regulatory protein
FH965_RS29005	COG3290	protein histidine kinase activity
FH965_RS29020	COG0372	Belongs to the citrate synthase family
FH965_RS29050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FH965_RS29055	COG0612	Peptidase, M16
FH965_RS29070	COG1802	Transcriptional regulator
FH965_RS29075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH965_RS29100	COG1435	thymidine kinase activity
FH965_RS29140	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FH965_RS29150	COG0745	RESPONSE REGULATOR receiver
FH965_RS29155	COG2205	protein histidine kinase activity
FH965_RS29180	COG0756	dUTP diphosphatase activity
FH965_RS29195	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FH965_RS29200	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FH965_RS29205	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FH965_RS29235	COG0569	domain protein
FH965_RS29255	COG0531	amino acid
FH965_RS29260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FH965_RS29295	COG1136	(ABC) transporter
FH965_RS29360	COG4974	Belongs to the 'phage' integrase family
FH965_RS29370	COG2197	response regulator
FH965_RS29375	COG4585	Histidine kinase
FH965_RS29405	COG1960	acyl-CoA dehydrogenase activity
FH965_RS29410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FH965_RS29415	COG0318	PFAM AMP-dependent synthetase and ligase
FH965_RS29430	COG0577	efflux transmembrane transporter activity
FH965_RS29430	COG1136	(ABC) transporter
FH965_RS29450	COG1799	cell septum assembly
FH965_RS29480	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FH965_RS29485	COG1595	DNA-templated transcription, initiation
FH965_RS29500	COG0745	RESPONSE REGULATOR receiver
FH965_RS29505	COG2205	protein histidine kinase activity
FH965_RS29515	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FH965_RS29525	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FH965_RS29535	COG1024	Enoyl-CoA hydratase
FH965_RS29575	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FH965_RS29580	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FH965_RS29590	COG0789	Transcriptional regulator
FH965_RS29690	COG1595	DNA-templated transcription, initiation
FH965_RS29710	COG4585	Histidine kinase
FH965_RS29715	COG2197	response regulator
FH965_RS29725	COG1175	transmembrane transport
FH965_RS29730	COG0395	ABC-type sugar transport system, permease component
FH965_RS29735	COG1940	carbohydrate kinase activity
FH965_RS29740	COG4213	ABC transporter substrate-binding protein
FH965_RS29750	COG4214	carbohydrate transport
FH965_RS29755	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FH965_RS29760	COG0531	amino acid
FH965_RS29770	COG2843	Capsule synthesis protein
FH965_RS29805	COG1250	3-hydroxyacyl-CoA dehydrogenase
FH965_RS29805	COG1024	Enoyl-CoA hydratase
FH965_RS29810	COG0183	Belongs to the thiolase family
FH965_RS29815	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FH965_RS29830	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FH965_RS29845	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FH965_RS29850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FH965_RS29860	COG0438	transferase activity, transferring glycosyl groups
FH965_RS29870	COG0446	pyridine nucleotide-disulphide oxidoreductase
FH965_RS29880	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FH965_RS29885	COG3253	May function as heme-dependent peroxidase
FH965_RS29910	COG3220	belongs to the UPF0276 family
FH965_RS29940	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FH965_RS29945	COG2326	polyphosphate kinase activity
FH965_RS29970	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FH965_RS29975	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FH965_RS30035	COG0443	Heat shock 70 kDa protein
FH965_RS30040	COG0443	Heat shock 70 kDa protein
FH965_RS30375	COG0504	CTP synthase activity
FH965_RS30380	COG0583	DNA-binding transcription factor activity
FH965_RS30400	COG0667	Aldo Keto reductase
FH965_RS30520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FH965_RS30525	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FH965_RS30545	COG0529	Catalyzes the synthesis of activated sulfate
FH965_RS30550	COG0175	sulfate reduction
FH965_RS30575	COG1960	acyl-CoA dehydrogenase activity
FH965_RS30590	COG1917	Cupin 2, conserved barrel domain protein
FH965_RS30590	COG4977	sequence-specific DNA binding
FH965_RS30610	COG3903	Transcriptional regulator
FH965_RS30610	COG3629	intracellular signal transduction
FH965_RS30615	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FH965_RS30645	COG1162	GTPase activity
FH965_RS30680	COG0028	Belongs to the TPP enzyme family
FH965_RS30705	COG1802	Transcriptional regulator
FH965_RS30735	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FH965_RS30740	COG2252	PERMEase
FH965_RS30750	COG2124	cytochrome p450
FH965_RS30795	COG0475	glutathione-regulated potassium exporter activity
FH965_RS30800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FH965_RS30820	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS30835	COG3321	synthase
FH965_RS30835	COG0318	PFAM AMP-dependent synthetase and ligase
FH965_RS30835	COG0300	oxidoreductase activity
FH965_RS30835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FH965_RS30835	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS30845	COG2124	cytochrome p450
FH965_RS30885	COG0514	ATP-dependent DNA helicase (RecQ)
FH965_RS30930	COG0583	DNA-binding transcription factor activity
FH965_RS30940	COG2197	response regulator
FH965_RS30945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FH965_RS30950	COG0318	PFAM AMP-dependent synthetase and ligase
FH965_RS30960	COG3960	tartronate-semialdehyde synthase activity
FH965_RS30965	COG0477	Major facilitator Superfamily
FH965_RS30980	COG0753	catalase activity
FH965_RS30985	COG2084	Dehydrogenase
FH965_RS30990	COG3622	Belongs to the hyi family
FH965_RS31010	COG2351	hydroxyisourate hydrolase activity
FH965_RS31020	COG2233	PERMEase
FH965_RS31030	COG2233	PERMEase
FH965_RS31055	COG5183	chlorophyll binding
FH965_RS31055	COG2133	pyrroloquinoline quinone binding
FH965_RS31105	COG0667	Aldo Keto reductase
FH965_RS31130	COG0406	alpha-ribazole phosphatase activity
FH965_RS31135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FH965_RS31145	COG0436	Aminotransferase
FH965_RS31160	COG2304	oxidoreductase activity
FH965_RS31170	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FH965_RS31195	COG1414	Transcriptional regulator
FH965_RS31200	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FH965_RS31205	COG4266	Belongs to the allantoicase family
FH965_RS31210	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS31245	COG2197	response regulator
FH965_RS31260	COG0673	inositol 2-dehydrogenase activity
FH965_RS31265	COG2188	Transcriptional regulator
FH965_RS31290	COG1940	carbohydrate kinase activity
FH965_RS31305	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FH965_RS31310	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FH965_RS31335	COG1126	abc transporter atp-binding protein
FH965_RS31340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH965_RS31345	COG0765	amino acid transport
FH965_RS31350	COG0765	amino acid transport
FH965_RS31360	COG1376	ErfK ybiS ycfS ynhG family protein
FH965_RS31370	COG0405	Gamma-glutamyltransferase
FH965_RS31400	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FH965_RS31405	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FH965_RS31415	COG1953	Uracil, thiamine, allantoin
FH965_RS31435	COG0483	inositol monophosphate 1-phosphatase activity
FH965_RS31445	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FH965_RS31475	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FH965_RS31480	COG1929	Belongs to the glycerate kinase type-1 family
FH965_RS31490	COG0688	phosphatidylethanolamine metabolic process
FH965_RS31495	COG1960	acyl-CoA dehydrogenase activity
FH965_RS31505	COG2301	Belongs to the HpcH HpaI aldolase family
FH965_RS31510	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FH965_RS31510	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FH965_RS31515	COG0604	alcohol dehydrogenase
FH965_RS31525	COG1250	3-hydroxyacyl-CoA dehydrogenase
FH965_RS31560	COG2172	sigma factor antagonist activity
FH965_RS31560	COG2208	phosphoserine phosphatase activity
FH965_RS31560	COG1366	Belongs to the anti-sigma-factor antagonist family
FH965_RS31565	COG2226	methyltransferase
FH965_RS31600	COG4974	Belongs to the 'phage' integrase family
FH965_RS31675	COG2362	D-Aminopeptidase
FH965_RS31680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FH965_RS31685	COG4946	Tricorn protease homolog
FH965_RS31685	COG0823	Involved in the tonB-independent uptake of proteins
FH965_RS31685	COG1506	peptidase
FH965_RS31690	COG1619	proteins homologs of microcin C7 resistance protein MccF
FH965_RS31705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FH965_RS31735	COG1252	NADH dehydrogenase
FH965_RS31800	COG2226	methyltransferase
FH965_RS31810	COG0488	(ABC) transporter
FH965_RS31825	COG0517	IMP dehydrogenase activity
FH965_RS31880	COG0531	amino acid
FH965_RS31895	COG0443	Heat shock 70 kDa protein
FH965_RS31910	COG2154	pterin-4-alpha-carbinolamine dehydratase
FH965_RS31915	COG2226	methyltransferase
FH965_RS31940	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FH965_RS31945	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
FH965_RS31980	COG0477	Major facilitator Superfamily
FH965_RS32010	COG0604	alcohol dehydrogenase
FH965_RS32015	COG1846	Transcriptional regulator
FH965_RS32020	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FH965_RS32035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FH965_RS32045	COG1940	carbohydrate kinase activity
FH965_RS32050	COG1129	ABC transporter
FH965_RS32055	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH965_RS32060	COG1879	ABC-type sugar transport system periplasmic component
FH965_RS32065	COG0673	inositol 2-dehydrogenase activity
FH965_RS32090	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FH965_RS32105	COG0084	hydrolase, TatD family'
FH965_RS32125	COG2223	nitrite transmembrane transporter activity
FH965_RS32140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FH965_RS32150	COG0045	succinate-CoA ligase (ADP-forming) activity
FH965_RS32210	COG1472	Belongs to the glycosyl hydrolase 3 family
FH965_RS32215	COG1063	alcohol dehydrogenase
FH965_RS32240	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FH965_RS32265	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FH965_RS32270	COG2197	response regulator
FH965_RS32280	COG4948	Mandelate Racemase Muconate Lactonizing
FH965_RS32285	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FH965_RS32300	COG1486	melibiose metabolic process
FH965_RS32315	COG0604	alcohol dehydrogenase
FH965_RS32315	COG3321	synthase
FH965_RS32320	COG3511	phospholipase C
FH965_RS32325	COG0525	valine-tRNA ligase activity
FH965_RS32355	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FH965_RS32360	COG1960	acyl-CoA dehydrogenase activity
FH965_RS32365	COG1960	acyl-CoA dehydrogenase activity
FH965_RS32375	COG1309	transcriptional regulator
FH965_RS32380	COG0183	Belongs to the thiolase family
FH965_RS32385	COG1672	PFAM Archaeal ATPase
FH965_RS32385	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FH965_RS32405	COG1024	Enoyl-CoA hydratase
FH965_RS32415	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS32420	COG3485	protocatechuate 3,4-dioxygenase
FH965_RS32425	COG3485	protocatechuate 3,4-dioxygenase
FH965_RS32440	COG1846	Transcriptional regulator
FH965_RS32450	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
FH965_RS32455	COG1793	dna ligase
FH965_RS32490	COG1090	epimerase
FH965_RS32525	COG3835	regulator
FH965_RS32535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FH965_RS32540	COG0488	(ABC) transporter
FH965_RS32565	COG3629	intracellular signal transduction
FH965_RS32565	COG3903	Transcriptional regulator
FH965_RS32570	COG3629	intracellular signal transduction
FH965_RS32570	COG3903	Transcriptional regulator
FH965_RS32585	COG3903	Transcriptional regulator
FH965_RS32585	COG3629	intracellular signal transduction
FH965_RS32595	COG1515	deoxyribonuclease V activity
FH965_RS32600	COG3268	Saccharopine dehydrogenase
FH965_RS32605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FH965_RS32610	COG1960	acyl-CoA dehydrogenase activity
FH965_RS32615	COG0183	Belongs to the thiolase family
FH965_RS32620	COG1024	Enoyl-CoA hydratase
FH965_RS32620	COG1250	3-hydroxyacyl-CoA dehydrogenase
FH965_RS32625	COG0789	Transcriptional regulator
FH965_RS32635	COG1113	amino acid transport
FH965_RS32645	COG2936	dipeptidyl-peptidase activity
FH965_RS32655	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FH965_RS32670	COG0488	(ABC) transporter
FH965_RS32675	COG2183	response to ionizing radiation
FH965_RS32695	COG1024	Enoyl-CoA hydratase
FH965_RS32710	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FH965_RS32755	COG1388	LysM domain
FH965_RS32755	COG1134	teichoic acid transport
FH965_RS32760	COG1562	ergosterol biosynthetic process
FH965_RS32770	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FH965_RS32780	COG1657	PFAM Prenyltransferase squalene oxidase
FH965_RS32795	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FH965_RS32800	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FH965_RS32820	COG2365	Tyrosine phosphatase family
FH965_RS32830	COG2755	lipolytic protein G-D-S-L family
FH965_RS32885	COG0673	inositol 2-dehydrogenase activity
FH965_RS32890	COG1063	alcohol dehydrogenase
FH965_RS32895	COG0156	8-amino-7-oxononanoate synthase activity
FH965_RS32900	COG0583	DNA-binding transcription factor activity
FH965_RS32915	COG3958	Transketolase
FH965_RS32920	COG3959	Transketolase, thiamine diphosphate binding domain
FH965_RS32965	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FH965_RS32970	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FH965_RS32975	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FH965_RS32985	COG2124	cytochrome p450
FH965_RS33000	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FH965_RS33005	COG0248	Ppx GppA phosphatase
FH965_RS33020	COG2226	methyltransferase
FH965_RS33035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FH965_RS33040	COG0156	8-amino-7-oxononanoate synthase activity
FH965_RS33045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FH965_RS33050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FH965_RS33055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FH965_RS33060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FH965_RS33095	COG1960	acyl-CoA dehydrogenase activity
FH965_RS33100	COG3321	synthase
FH965_RS33105	COG3629	intracellular signal transduction
FH965_RS33115	COG0842	Transport permease protein
FH965_RS33115	COG1129	ABC transporter
FH965_RS33125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FH965_RS33130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FH965_RS33135	COG0668	transmembrane transport
FH965_RS33155	COG1846	Transcriptional regulator
FH965_RS33155	COG1940	carbohydrate kinase activity
FH965_RS33165	COG1175	transmembrane transport
FH965_RS33170	COG0395	ABC-type sugar transport system, permease component
FH965_RS33185	COG2340	Cysteine-rich secretory protein family
FH965_RS33200	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS33235	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FH965_RS33255	COG0318	PFAM AMP-dependent synthetase and ligase
FH965_RS33265	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FH965_RS33285	COG2124	cytochrome p450
FH965_RS33290	COG0604	alcohol dehydrogenase
FH965_RS33290	COG3321	synthase
FH965_RS33295	COG0604	alcohol dehydrogenase
FH965_RS33295	COG3321	synthase
FH965_RS33310	COG0183	Belongs to the thiolase family
FH965_RS33350	COG1175	transmembrane transport
FH965_RS33355	COG0395	ABC-type sugar transport system, permease component
FH965_RS33360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FH965_RS33370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FH965_RS33390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FH965_RS33405	COG3629	intracellular signal transduction
FH965_RS33405	COG3903	Transcriptional regulator
FH965_RS33420	COG4044	May play a role in the intracellular transport of hydrophobic ligands
FH965_RS33445	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS33480	COG1132	(ABC) transporter
FH965_RS33495	COG2977	Belongs to the P-Pant transferase superfamily
FH965_RS33525	COG1131	(ABC) transporter
FH965_RS33550	COG0604	alcohol dehydrogenase
FH965_RS33550	COG3321	synthase
FH965_RS33605	COG0318	PFAM AMP-dependent synthetase and ligase
FH965_RS33615	COG2124	cytochrome p450
FH965_RS33635	COG4585	Histidine kinase
FH965_RS33640	COG2197	response regulator
FH965_RS33645	COG4585	Histidine kinase
FH965_RS33660	COG2409	Drug exporters of the RND superfamily
FH965_RS33680	COG1278	Cold shock
FH965_RS33710	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FH965_RS33730	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FH965_RS33735	COG3458	cephalosporin-C deacetylase activity
FH965_RS33755	COG0297	glycogen (starch) synthase activity
FH965_RS33760	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FH965_RS33765	COG0745	RESPONSE REGULATOR receiver
FH965_RS33780	COG0326	Molecular chaperone. Has ATPase activity
FH965_RS33815	COG1609	Transcriptional regulator
FH965_RS33820	COG1653	transport
FH965_RS33825	COG1175	transmembrane transport
FH965_RS33830	COG0395	ABC-type sugar transport system, permease component
FH965_RS33855	COG2186	Transcriptional regulator
FH965_RS33865	COG1129	ABC transporter
FH965_RS33875	COG4948	Mandelate Racemase Muconate Lactonizing
FH965_RS33925	COG2197	response regulator
FH965_RS33930	COG4585	Histidine kinase
FH965_RS33955	COG1595	DNA-templated transcription, initiation
FH965_RS33960	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FH965_RS33985	COG0531	amino acid
FH965_RS33995	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FH965_RS33995	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FH965_RS34025	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FH965_RS34035	COG0583	DNA-binding transcription factor activity
FH965_RS34045	COG0667	Aldo Keto reductase
FH965_RS34090	COG1053	succinate dehydrogenase
FH965_RS34095	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FH965_RS34100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FH965_RS34120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH965_RS34135	COG2182	Extracellular solute-binding protein
FH965_RS34140	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
FH965_RS34150	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FH965_RS34155	COG3572	ergothioneine biosynthetic process
FH965_RS34170	COG1609	Transcriptional regulator
FH965_RS34175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FH965_RS34200	COG0438	transferase activity, transferring glycosyl groups
FH965_RS34205	COG0745	RESPONSE REGULATOR receiver
FH965_RS34245	COG0028	Belongs to the TPP enzyme family
FH965_RS34260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FH965_RS34270	COG0531	amino acid
FH965_RS34275	COG0460	homoserine dehydrogenase
FH965_RS34315	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FH965_RS34325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FH965_RS34375	COG2197	response regulator
FH965_RS34380	COG4585	Histidine kinase
FH965_RS34390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FH965_RS34400	COG0789	Transcriptional regulator
FH965_RS34425	COG3629	intracellular signal transduction
FH965_RS34425	COG3903	Transcriptional regulator
FH965_RS34470	COG0346	lactoylglutathione lyase activity
FH965_RS34475	COG1191	sigma factor activity
FH965_RS34480	COG1366	Belongs to the anti-sigma-factor antagonist family
FH965_RS34485	COG1366	Belongs to the anti-sigma-factor antagonist family
FH965_RS34490	COG2172	sigma factor antagonist activity
FH965_RS34500	COG2770	Histidine kinase
FH965_RS34500	COG2208	phosphoserine phosphatase activity
FH965_RS34535	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FH965_RS34545	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS34565	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FH965_RS34565	COG1672	PFAM Archaeal ATPase
FH965_RS34570	COG3467	pyridoxamine 5'-phosphate
FH965_RS34595	COG2192	nodulation
FH965_RS34600	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FH965_RS34620	COG0583	DNA-binding transcription factor activity
FH965_RS34655	COG2223	nitrite transmembrane transporter activity
FH965_RS34665	COG0019	diaminopimelate decarboxylase activity
FH965_RS34680	COG1472	Belongs to the glycosyl hydrolase 3 family
FH965_RS34690	COG1174	glycine betaine transport
FH965_RS34695	COG1174	glycine betaine transport
FH965_RS34705	COG4106	trans-aconitate 2-methyltransferase activity
FH965_RS34710	COG1125	glycine betaine transport
FH965_RS34710	COG0517	IMP dehydrogenase activity
FH965_RS34715	COG1556	Lactate utilization protein
FH965_RS34720	COG1139	Iron-sulfur cluster binding protein
FH965_RS34725	COG0247	lactate metabolic process
FH965_RS34750	COG1960	acyl-CoA dehydrogenase activity
FH965_RS34755	COG1960	acyl-CoA dehydrogenase activity
FH965_RS34765	COG0601	transmembrane transport
FH965_RS34770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FH965_RS34775	COG0444	Belongs to the ABC transporter superfamily
FH965_RS34790	COG0725	ABC transporter, periplasmic molybdate-binding protein
FH965_RS34795	COG3585	molybdate ion transport
FH965_RS34810	COG2814	Major facilitator Superfamily
FH965_RS34815	COG1070	Carbohydrate kinase
FH965_RS34820	COG1070	Carbohydrate kinase
FH965_RS34825	COG0588	phosphoglycerate mutase activity
FH965_RS34830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FH965_RS34875	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FH965_RS34880	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FH965_RS34900	COG3845	ABC transporter
FH965_RS34935	COG0673	inositol 2-dehydrogenase activity
FH965_RS34940	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FH965_RS34945	COG0463	Glycosyl transferase, family 2
FH965_RS34950	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FH965_RS34970	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FH965_RS34975	COG0673	inositol 2-dehydrogenase activity
FH965_RS35000	COG2175	clavaminate synthase activity
FH965_RS35045	COG1121	(ABC) transporter
FH965_RS35050	COG0142	geranyltranstransferase activity
FH965_RS35110	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
FH965_RS35125	COG2226	methyltransferase
FH965_RS35140	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FH965_RS35155	COG2368	4-hydroxyphenylacetate
FH965_RS35160	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FH965_RS35180	COG0076	glutamate decarboxylase activity
FH965_RS35185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FH965_RS35200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FH965_RS35235	COG2162	N-hydroxyarylamine O-acetyltransferase activity
FH965_RS35250	COG1597	lipid kinase activity
FH965_RS35265	COG0488	(ABC) transporter
FH965_RS35270	COG0488	(ABC) transporter
FH965_RS35325	COG0367	asparagine synthase
FH965_RS35330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FH965_RS35335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FH965_RS35470	COG1012	belongs to the aldehyde dehydrogenase family
FH965_RS35490	COG1940	carbohydrate kinase activity
FH965_RS35495	COG1070	Carbohydrate kinase
FH965_RS35500	COG2115	Belongs to the xylose isomerase family
FH965_RS35525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FH965_RS35585	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FH965_RS35615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FH965_RS35665	COG2018	Roadblock/LC7 domain
FH965_RS35680	COG1946	Acyl-CoA thioesterase
FH965_RS35695	COG0477	Major facilitator Superfamily
FH965_RS35700	COG1132	(ABC) transporter
FH965_RS35705	COG1132	(ABC) transporter
FH965_RS35725	COG1846	Transcriptional regulator
FH965_RS35730	COG1132	(ABC) transporter
FH965_RS35760	COG0477	Major facilitator Superfamily
FH965_RS35770	COG2072	flavoprotein involved in K transport
FH965_RS35780	COG4948	Mandelate Racemase Muconate Lactonizing
FH965_RS35795	COG1116	anion transmembrane transporter activity
FH965_RS35800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FH965_RS35805	COG0432	Pfam Uncharacterised protein family UPF0047
FH965_RS35815	COG2080	2 iron, 2 sulfur cluster binding
FH965_RS35820	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FH965_RS35825	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FH965_RS35835	COG2814	Major facilitator Superfamily
FH965_RS35870	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FH965_RS35880	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FH965_RS35890	COG1960	acyl-CoA dehydrogenase activity
FH965_RS35895	COG1024	Enoyl-CoA hydratase
FH965_RS35910	COG0546	phosphoglycolate phosphatase activity
FH965_RS35920	COG0531	amino acid
FH965_RS35940	COG2706	6-phosphogluconolactonase activity
FH965_RS35955	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FH965_RS35970	COG2040	homocysteine
FH965_RS35980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FH965_RS35990	COG0747	negative chemotaxis
FH965_RS36050	COG1228	amidohydrolase
FH965_RS36060	COG1902	pentaerythritol trinitrate reductase activity
FH965_RS36065	COG0640	Transcriptional regulator
FH965_RS36110	COG0671	phosphoesterase, PA-phosphatase related
FH965_RS36130	COG1846	Transcriptional regulator
FH965_RS36145	COG0584	glycerophosphoryl diester phosphodiesterase
FH965_RS36185	COG0204	Acyl-transferase
FH965_RS36205	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FH965_RS36230	COG3345	alpha-galactosidase
FH965_RS36240	COG1175	transmembrane transport
FH965_RS36245	COG0395	ABC-type sugar transport system, permease component
FH965_RS36265	COG3237	CsbD-like
FH965_RS36270	COG2910	NAD(P)H-binding
FH965_RS36305	COG1660	Displays ATPase and GTPase activities
FH965_RS36325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FH965_RS36330	COG2197	response regulator
FH965_RS36340	COG0445	tRNA wobble uridine modification
FH965_RS36345	COG0745	RESPONSE REGULATOR receiver
FH965_RS36350	COG4585	Histidine kinase
FH965_RS36355	COG2197	response regulator
FH965_RS36385	COG2223	nitrite transmembrane transporter activity
FH965_RS36390	COG1940	carbohydrate kinase activity
FH965_RS36435	COG0577	efflux transmembrane transporter activity
FH965_RS36460	COG1349	DNA-binding transcription factor activity
FH965_RS36495	COG1215	transferase activity, transferring glycosyl groups
FH965_RS36500	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FH965_RS36535	COG2205	protein histidine kinase activity
FH965_RS36540	COG0745	RESPONSE REGULATOR receiver
FH965_RS36550	COG2755	lipolytic protein G-D-S-L family
FH965_RS36550	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FH965_RS36560	COG2813	Specifically methylates the guanine in position
FH965_RS36565	COG3145	DNA-N1-methyladenine dioxygenase activity
FH965_RS36570	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FH965_RS36595	COG1902	pentaerythritol trinitrate reductase activity
FH965_RS36595	COG0446	pyridine nucleotide-disulphide oxidoreductase
FH965_RS36610	COG0673	inositol 2-dehydrogenase activity
FH965_RS36640	COG1012	belongs to the aldehyde dehydrogenase family
FH965_RS36655	COG0154	amidase activity
FH965_RS36670	COG0346	lactoylglutathione lyase activity
FH965_RS36690	COG0657	acetylesterase activity
FH965_RS36695	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS36715	COG0456	acetyltransferase
FH965_RS36740	COG1940	carbohydrate kinase activity
FH965_RS36750	COG1461	Dihydroxyacetone kinase
FH965_RS36755	COG2376	Dihydroxyacetone kinase
FH965_RS36825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FH965_RS36830	COG1181	Belongs to the D-alanine--D-alanine ligase family
FH965_RS36895	COG0583	DNA-binding transcription factor activity
FH965_RS36915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FH965_RS36925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FH965_RS36930	COG2409	Drug exporters of the RND superfamily
FH965_RS36940	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FH965_RS36945	COG2205	protein histidine kinase activity
FH965_RS36985	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FH965_RS37010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FH965_RS37025	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
FH965_RS37055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FH965_RS37065	COG3964	amidohydrolase
FH965_RS37075	COG1960	acyl-CoA dehydrogenase activity
FH965_RS37085	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FH965_RS37090	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FH965_RS37105	COG0166	Belongs to the GPI family
FH965_RS37110	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FH965_RS37125	COG0640	Transcriptional regulator
FH965_RS37135	COG0515	serine threonine protein kinase
FH965_RS37160	COG3433	isochorismatase activity
FH965_RS37160	COG1535	isochorismatase
FH965_RS37170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FH965_RS37175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH965_RS37180	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH965_RS37185	COG1120	ATPase activity
FH965_RS37235	COG0443	Heat shock 70 kDa protein
FH965_RS37280	COG2226	methyltransferase
FH965_RS37295	COG3693	PFAM glycoside hydrolase, family 10
FH965_RS37340	COG1295	ribonuclease BN
FH965_RS37350	COG2070	2-Nitropropane dioxygenase
FH965_RS37360	COG1366	Belongs to the anti-sigma-factor antagonist family
FH965_RS37410	COG0330	HflC and HflK could
FH965_RS37560	COG2197	response regulator
FH965_RS37575	COG0318	PFAM AMP-dependent synthetase and ligase
FH965_RS37615	COG3920	Histidine kinase
FH965_RS37705	COG3629	intracellular signal transduction
FH965_RS37705	COG3903	Transcriptional regulator
FH965_RS37730	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FH965_RS37735	COG1132	(ABC) transporter
FH965_RS37770	COG1605	Chorismate mutase
FH965_RS37780	COG1335	isochorismatase
FH965_RS37790	COG1595	DNA-templated transcription, initiation
FH965_RS37805	COG1024	Enoyl-CoA hydratase
FH965_RS37850	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FH965_RS37850	COG0515	serine threonine protein kinase
FH965_RS37855	COG2409	Drug exporters of the RND superfamily
FH965_RS37885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH965_RS37890	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH965_RS37895	COG1120	ATPase activity
FH965_RS37900	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FH965_RS37905	COG1132	(ABC) transporter
FH965_RS37915	COG1132	(ABC) transporter
FH965_RS37920	COG2382	esterase
FH965_RS37935	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FH965_RS37940	COG3486	L-lysine 6-monooxygenase (NADPH) activity
FH965_RS38000	COG0596	Alpha beta hydrolase
FH965_RS38070	COG2197	response regulator
FH965_RS38075	COG4585	Histidine kinase
FH965_RS38095	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FH965_RS38100	COG1595	DNA-templated transcription, initiation
FH965_RS38105	COG0181	hydroxymethylbilane synthase activity
FH965_RS38110	COG0477	Major facilitator Superfamily
FH965_RS38170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FH965_RS38200	COG1793	dna ligase
FH965_RS38205	COG0825	malonyl-CoA metabolic process
FH965_RS38205	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FH965_RS38225	COG0673	inositol 2-dehydrogenase activity
FH965_RS38230	COG1686	Belongs to the peptidase S11 family
FH965_RS38240	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FH965_RS38245	COG2223	nitrite transmembrane transporter activity
FH965_RS38250	COG2207	Transcriptional regulator
FH965_RS38275	COG3708	Transcriptional regulator
FH965_RS38275	COG2207	Transcriptional regulator
FH965_RS38285	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FH965_RS38290	COG2318	DinB family
FH965_RS38295	COG0386	Belongs to the glutathione peroxidase family
FH965_RS38330	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FH965_RS38335	COG2706	6-phosphogluconolactonase activity
FH965_RS38390	COG0789	Transcriptional regulator
FH965_RS38395	COG1819	glycosyl
FH965_RS38400	COG0435	Glutathione S-transferase
FH965_RS38415	COG1309	transcriptional regulator
FH965_RS38460	COG0667	Aldo Keto reductase
FH965_RS38465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FH965_RS38475	COG1132	(ABC) transporter
FH965_RS38495	COG0252	asparaginase activity
FH965_RS38555	COG0477	Major facilitator Superfamily
FH965_RS38570	COG0456	acetyltransferase
FH965_RS38575	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FH965_RS38590	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FH965_RS38590	COG2124	cytochrome p450
FH965_RS38670	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FH965_RS38685	COG2124	cytochrome p450
FH965_RS38710	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FH965_RS38725	COG1609	Transcriptional regulator
FH965_RS38730	COG1957	nucleoside hydrolase
FH965_RS38735	COG0477	Major facilitator Superfamily
FH965_RS38745	COG2197	response regulator
FH965_RS38765	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FH965_RS38770	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FH965_RS38775	COG2080	2 iron, 2 sulfur cluster binding
FH965_RS38810	COG2340	Cysteine-rich secretory protein family
FH965_RS38815	COG0793	Belongs to the peptidase S41A family
FH965_RS38830	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FH965_RS38880	COG1960	acyl-CoA dehydrogenase activity
FH965_RS38890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FH965_RS38910	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FH965_RS38925	COG2066	Belongs to the glutaminase family
FH965_RS38935	COG1140	nitrate reductase beta subunit
FH965_RS38940	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
FH965_RS38955	COG1846	Transcriptional regulator
FH965_RS38980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FH965_RS39010	COG0642	Histidine kinase
FH965_RS39010	COG3850	Histidine kinase
FH965_RS39020	COG0318	PFAM AMP-dependent synthetase and ligase
FH965_RS39035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FH965_RS39095	COG4977	sequence-specific DNA binding
FH965_RS39115	COG2197	response regulator
FH965_RS39140	COG0494	nUDIX hydrolase
FH965_RS39160	COG1733	regulation of RNA biosynthetic process
FH965_RS39165	COG0251	oxidation-reduction process
FH965_RS39225	COG0456	acetyltransferase
FH965_RS39280	COG0702	epimerase
FH965_RS39285	COG1595	DNA-templated transcription, initiation
FH965_RS39320	COG2124	cytochrome p450
FH965_RS39340	COG3251	PFAM MbtH domain protein
FH965_RS39360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FH965_RS39390	COG0596	Alpha beta hydrolase
FH965_RS39415	COG2264	protein methyltransferase activity
FH965_RS39440	COG1404	Belongs to the peptidase S8 family
FH965_RS39445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FH965_RS39470	COG0154	amidase activity
FH965_RS39490	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS39495	COG4989	oxidoreductase activity
FH965_RS39530	COG0596	Alpha beta hydrolase
FH965_RS39555	COG1819	glycosyl
FH965_RS39615	COG0789	Transcriptional regulator
FH965_RS39735	COG1309	transcriptional regulator
FH965_RS39750	COG1051	belongs to the nudix hydrolase family
FH965_RS39755	COG0494	nUDIX hydrolase
FH965_RS39760	COG1132	(ABC) transporter
FH965_RS39770	COG1595	DNA-templated transcription, initiation
FH965_RS39780	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FH965_RS39785	COG0640	Transcriptional regulator
FH965_RS39865	COG0583	DNA-binding transcription factor activity
FH965_RS39920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FH965_RS39935	COG2319	Wd-40 repeat
FH965_RS39935	COG4249	Peptidase C14 caspase catalytic subunit p20
FH965_RS39960	COG0142	geranyltranstransferase activity
FH965_RS40075	COG0702	epimerase
FH965_RS40095	COG0477	Major facilitator Superfamily
FH965_RS40110	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FH965_RS40130	COG0693	protein deglycase activity
FH965_RS40140	COG0028	Belongs to the TPP enzyme family
FH965_RS40160	COG0366	Alpha amylase catalytic
FH965_RS40180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FH965_RS40190	COG1595	DNA-templated transcription, initiation
FH965_RS40195	COG2814	Major facilitator Superfamily
FH965_RS40205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FH965_RS40225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH965_RS40260	COG0318	PFAM AMP-dependent synthetase and ligase
FH965_RS40260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FH965_RS40265	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FH965_RS40265	COG0512	Glutamine amidotransferase of anthranilate synthase
FH965_RS40270	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FH965_RS40290	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FH965_RS40300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FH965_RS40305	COG0667	Aldo Keto reductase
FH965_RS40310	COG0277	FAD linked oxidase domain protein
FH965_RS40315	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FH965_RS40320	COG1028	Short-chain dehydrogenase reductase Sdr
FH965_RS40355	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FH965_RS40355	COG2010	Cytochrome c
FH965_RS40360	COG0640	Transcriptional regulator
FH965_RS40370	COG0789	Transcriptional regulator
FH965_RS40375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH965_RS40410	COG1012	belongs to the aldehyde dehydrogenase family