locus-tag	class	description
F3L20_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F3L20_RS00015	COG0592	DNA-directed DNA polymerase activity
F3L20_RS00020	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
F3L20_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F3L20_RS00030	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
F3L20_RS00035	COG0187	DNA topoisomerase II activity
F3L20_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F3L20_RS00045	COG3266	domain, Protein
F3L20_RS00075	COG0515	serine threonine protein kinase
F3L20_RS00100	COG0705	Rhomboid family
F3L20_RS00125	COG3764	Sortase (surface protein transpeptidase)
F3L20_RS00130	COG3764	Sortase (surface protein transpeptidase)
F3L20_RS00135	COG0515	serine threonine protein kinase
F3L20_RS00140	COG0768	penicillin binding
F3L20_RS00155	COG1716	ATPase activity
F3L20_RS00160	COG1716	ATPase activity
F3L20_RS00180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F3L20_RS00185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F3L20_RS00190	COG2151	metal-sulfur cluster biosynthetic enzyme
F3L20_RS00195	COG3396	Phenylacetate-CoA oxygenase
F3L20_RS00200	COG3460	Phenylacetate-CoA oxygenase
F3L20_RS00205	COG3396	Phenylacetate-CoA oxygenase
F3L20_RS00230	COG1250	3-hydroxyacyl-CoA dehydrogenase
F3L20_RS00235	COG1309	transcriptional regulator
F3L20_RS00240	COG1522	sequence-specific DNA binding
F3L20_RS00265	COG0303	'Molybdopterin
F3L20_RS00285	COG0604	alcohol dehydrogenase
F3L20_RS00285	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS00285	COG3321	synthase
F3L20_RS00300	COG0515	serine threonine protein kinase
F3L20_RS00305	COG0515	serine threonine protein kinase
F3L20_RS00315	COG0022	dehydrogenase e1 component
F3L20_RS00320	COG0508	dehydrogenase complex catalyzes the overall conversion of
F3L20_RS00365	COG1362	aminopeptidase activity
F3L20_RS00370	COG1960	acyl-CoA dehydrogenase activity
F3L20_RS00380	COG1741	Belongs to the pirin family
F3L20_RS00390	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F3L20_RS00410	COG0326	Molecular chaperone. Has ATPase activity
F3L20_RS00420	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F3L20_RS00435	COG0583	DNA-binding transcription factor activity
F3L20_RS00480	COG1653	transport
F3L20_RS00505	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F3L20_RS00515	COG0366	Alpha amylase catalytic
F3L20_RS00530	COG2409	Drug exporters of the RND superfamily
F3L20_RS00555	COG1278	Cold shock
F3L20_RS00565	COG0583	DNA-binding transcription factor activity
F3L20_RS00590	COG4213	ABC transporter substrate-binding protein
F3L20_RS00600	COG1595	DNA-templated transcription, initiation
F3L20_RS00615	COG2197	response regulator
F3L20_RS00625	COG2172	sigma factor antagonist activity
F3L20_RS00625	COG1366	Belongs to the anti-sigma-factor antagonist family
F3L20_RS00625	COG2208	phosphoserine phosphatase activity
F3L20_RS00685	COG0745	RESPONSE REGULATOR receiver
F3L20_RS00690	COG2205	protein histidine kinase activity
F3L20_RS00705	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
F3L20_RS00725	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F3L20_RS00870	COG0717	Belongs to the dCTP deaminase family
F3L20_RS00875	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
F3L20_RS00965	COG0464	growth
F3L20_RS00985	COG2181	nitrate reductase activity
F3L20_RS00985	COG0247	lactate metabolic process
F3L20_RS00990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F3L20_RS00995	COG0443	Heat shock 70 kDa protein
F3L20_RS01000	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F3L20_RS01005	COG0484	heat shock protein binding
F3L20_RS01010	COG0789	Transcriptional regulator
F3L20_RS01015	COG4213	ABC transporter substrate-binding protein
F3L20_RS01050	COG0542	response to heat
F3L20_RS01095	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
F3L20_RS01110	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F3L20_RS01115	COG0191	fructose-bisphosphate aldolase activity
F3L20_RS01120	COG0477	Major facilitator Superfamily
F3L20_RS01130	COG3483	tryptophan 2,3-dioxygenase activity
F3L20_RS01135	COG3844	kynureninase activity
F3L20_RS01155	COG4585	Histidine kinase
F3L20_RS01160	COG2197	response regulator
F3L20_RS01165	COG4585	Histidine kinase
F3L20_RS01170	COG2197	response regulator
F3L20_RS01185	COG3559	Exporter of polyketide antibiotics
F3L20_RS01190	COG1131	(ABC) transporter
F3L20_RS01205	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F3L20_RS01220	COG1802	Transcriptional regulator
F3L20_RS01225	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F3L20_RS01230	COG0693	protein deglycase activity
F3L20_RS01255	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F3L20_RS01260	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F3L20_RS01290	COG1595	DNA-templated transcription, initiation
F3L20_RS01325	COG0475	glutathione-regulated potassium exporter activity
F3L20_RS01375	COG1408	metallophosphoesterase
F3L20_RS01385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F3L20_RS01400	COG0003	Pfam Anion-transporting ATPase
F3L20_RS01460	COG2267	carboxylic ester hydrolase activity
F3L20_RS01470	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F3L20_RS01475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F3L20_RS01480	COG0659	secondary active sulfate transmembrane transporter activity
F3L20_RS01540	COG1111	helicase
F3L20_RS01540	COG1205	dead DEAH box helicase
F3L20_RS01545	COG1366	Belongs to the anti-sigma-factor antagonist family
F3L20_RS01550	COG2172	sigma factor antagonist activity
F3L20_RS01555	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
F3L20_RS01565	COG2264	protein methyltransferase activity
F3L20_RS01575	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F3L20_RS01575	COG1754	DNA topoisomerase type I activity
F3L20_RS01580	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F3L20_RS01700	COG3629	intracellular signal transduction
F3L20_RS01700	COG3903	Transcriptional regulator
F3L20_RS01705	COG3629	intracellular signal transduction
F3L20_RS01705	COG3903	Transcriptional regulator
F3L20_RS01710	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F3L20_RS01710	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F3L20_RS01750	COG1012	belongs to the aldehyde dehydrogenase family
F3L20_RS01770	COG0076	glutamate decarboxylase activity
F3L20_RS01780	COG0789	Transcriptional regulator
F3L20_RS01785	COG0586	Pfam SNARE associated Golgi protein
F3L20_RS01795	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F3L20_RS01800	COG2027	D-alanyl-D-alanine carboxypeptidase
F3L20_RS01810	COG0037	tRNA processing
F3L20_RS01825	COG0302	gtp cyclohydrolase
F3L20_RS01840	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F3L20_RS01870	COG0649	NAD binding
F3L20_RS01885	COG2197	response regulator
F3L20_RS01890	COG1660	Displays ATPase and GTPase activities
F3L20_RS01915	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F3L20_RS01920	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F3L20_RS01930	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
F3L20_RS01950	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
F3L20_RS01980	COG0739	heme binding
F3L20_RS02000	COG2205	protein histidine kinase activity
F3L20_RS02005	COG0745	RESPONSE REGULATOR receiver
F3L20_RS02015	COG1595	DNA-templated transcription, initiation
F3L20_RS02020	COG1194	a g-specific adenine glycosylase
F3L20_RS02045	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
F3L20_RS02065	COG0248	Ppx GppA phosphatase
F3L20_RS02070	COG1082	Xylose isomerase domain protein TIM barrel
F3L20_RS02075	COG1309	transcriptional regulator
F3L20_RS02080	COG0129	dihydroxy-acid dehydratase activity
F3L20_RS02085	COG0515	serine threonine protein kinase
F3L20_RS02085	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F3L20_RS02090	COG4991	sh3 domain protein
F3L20_RS02105	COG1129	ABC transporter
F3L20_RS02105	COG0842	Transport permease protein
F3L20_RS02115	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F3L20_RS02120	COG1335	isochorismatase
F3L20_RS02130	COG0180	Tryptophanyl-tRNA synthetase
F3L20_RS02155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F3L20_RS02165	COG0123	including yeast histone deacetylase and acetoin utilization protein
F3L20_RS02215	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
F3L20_RS02220	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F3L20_RS02225	COG0181	hydroxymethylbilane synthase activity
F3L20_RS02230	COG1648	precorrin-2 dehydrogenase activity
F3L20_RS02230	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F3L20_RS02250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F3L20_RS02260	COG1280	lysine exporter protein (LysE YggA)
F3L20_RS02265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F3L20_RS02275	COG0113	porphobilinogen synthase activity
F3L20_RS02290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F3L20_RS02300	COG3409	Peptidoglycan-binding domain 1 protein
F3L20_RS02300	COG5632	N-Acetylmuramoyl-L-alanine amidase
F3L20_RS02310	COG0018	arginyl-trna synthetase
F3L20_RS02315	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
F3L20_RS02335	COG1690	Belongs to the RtcB family
F3L20_RS02340	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F3L20_RS02350	COG1742	UPF0060 membrane protein
F3L20_RS02355	COG1846	Transcriptional regulator
F3L20_RS02360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3L20_RS02380	COG2205	protein histidine kinase activity
F3L20_RS02385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F3L20_RS02390	COG1116	anion transmembrane transporter activity
F3L20_RS02410	COG0596	Alpha beta hydrolase
F3L20_RS02460	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS02465	COG0640	Transcriptional regulator
F3L20_RS02480	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F3L20_RS02485	COG0406	alpha-ribazole phosphatase activity
F3L20_RS02500	COG0785	Cytochrome C biogenesis protein
F3L20_RS02505	COG1333	cytochrome c biogenesis protein
F3L20_RS02510	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F3L20_RS02535	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F3L20_RS02540	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F3L20_RS02550	COG0163	prenyltransferase activity
F3L20_RS02560	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F3L20_RS02565	COG1573	uracil-dna glycosylase
F3L20_RS02580	COG1301	dicarboxylic acid transport
F3L20_RS02600	COG1309	transcriptional regulator
F3L20_RS02610	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS02615	COG0183	Belongs to the thiolase family
F3L20_RS02645	COG1278	Cold shock
F3L20_RS02655	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
F3L20_RS02805	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F3L20_RS02815	COG3979	chitinase
F3L20_RS02820	COG2226	methyltransferase
F3L20_RS02855	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F3L20_RS02860	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F3L20_RS02865	COG0649	NAD binding
F3L20_RS02875	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F3L20_RS02880	COG1034	ATP synthesis coupled electron transport
F3L20_RS02885	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F3L20_RS02890	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F3L20_RS02895	COG0839	Belongs to the complex I subunit 6 family
F3L20_RS02900	COG0713	ATP synthesis coupled electron transport
F3L20_RS02905	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F3L20_RS02915	COG1007	ATP synthesis coupled electron transport
F3L20_RS02920	COG0514	ATP-dependent DNA helicase (RecQ)
F3L20_RS02935	COG0561	phosphatase activity
F3L20_RS02945	COG0142	geranyltranstransferase activity
F3L20_RS02955	COG1131	(ABC) transporter
F3L20_RS03005	COG0702	epimerase
F3L20_RS03015	COG1013	pyruvate-flavodoxin oxidoreductase activity
F3L20_RS03020	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
F3L20_RS03020	COG0674	pyruvate-flavodoxin oxidoreductase activity
F3L20_RS03040	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F3L20_RS03045	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F3L20_RS03050	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F3L20_RS03055	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F3L20_RS03060	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F3L20_RS03070	COG0713	ATP synthesis coupled electron transport
F3L20_RS03075	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F3L20_RS03085	COG1007	ATP synthesis coupled electron transport
F3L20_RS03090	COG0501	Belongs to the peptidase M48B family
F3L20_RS03095	COG3304	Inner membrane component domain
F3L20_RS03105	COG2261	transglycosylase associated protein
F3L20_RS03110	COG1666	GTP binding
F3L20_RS03130	COG0702	epimerase
F3L20_RS03150	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F3L20_RS03155	COG2030	dehydratase
F3L20_RS03165	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F3L20_RS03175	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F3L20_RS03180	COG0436	Aminotransferase
F3L20_RS03195	COG0250	Participates in transcription elongation, termination and antitermination
F3L20_RS03200	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F3L20_RS03205	COG0081	regulation of translation
F3L20_RS03220	COG0222	ribosome binding
F3L20_RS03230	COG0085	RNA polymerase activity
F3L20_RS03235	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F3L20_RS03245	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F3L20_RS03250	COG0049	tRNA binding
F3L20_RS03255	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F3L20_RS03260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F3L20_RS03270	COG0667	Aldo Keto reductase
F3L20_RS03300	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F3L20_RS03340	COG0051	transcription antitermination factor activity, RNA binding
F3L20_RS03345	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F3L20_RS03350	COG0088	Forms part of the polypeptide exit tunnel
F3L20_RS03355	COG0089	rRNA binding
F3L20_RS03360	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F3L20_RS03365	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F3L20_RS03370	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F3L20_RS03375	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F3L20_RS03380	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F3L20_RS03385	COG0255	Belongs to the universal ribosomal protein uL29 family
F3L20_RS03390	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F3L20_RS03395	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F3L20_RS03400	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F3L20_RS03405	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F3L20_RS03410	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F3L20_RS03420	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F3L20_RS03425	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F3L20_RS03430	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F3L20_RS03435	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F3L20_RS03440	COG1841	ribosomal large subunit assembly
F3L20_RS03445	COG0200	Binds to the 23S rRNA
F3L20_RS03455	COG0563	adenylate kinase activity
F3L20_RS03465	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F3L20_RS03470	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F3L20_RS03475	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F3L20_RS03480	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F3L20_RS03485	COG0202	RNA polymerase activity
F3L20_RS03490	COG0203	ribosomal protein L17
F3L20_RS03495	COG0101	tRNA pseudouridine synthase activity
F3L20_RS03510	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F3L20_RS03515	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F3L20_RS03520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F3L20_RS03530	COG1072	(Pantothenic acid kinase))
F3L20_RS03540	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F3L20_RS03545	COG0736	holo-[acyl-carrier-protein] synthase activity
F3L20_RS03550	COG1191	sigma factor activity
F3L20_RS03560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F3L20_RS03570	COG0802	atpase or kinase
F3L20_RS03580	COG0456	acetyltransferase
F3L20_RS03580	COG1214	PFAM Peptidase M22, glycoprotease
F3L20_RS03590	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F3L20_RS03615	COG4941	Belongs to the sigma-70 factor family
F3L20_RS03625	COG0726	polysaccharide deacetylase
F3L20_RS03630	COG0726	polysaccharide deacetylase
F3L20_RS03640	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F3L20_RS03645	COG0459	protein refolding
F3L20_RS03665	COG4221	oxidoreductase activity
F3L20_RS03675	COG0583	DNA-binding transcription factor activity
F3L20_RS03690	COG1595	DNA-templated transcription, initiation
F3L20_RS03700	COG0516	GMP reductase activity
F3L20_RS03710	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F3L20_RS03725	COG0515	serine threonine protein kinase
F3L20_RS03730	COG0515	serine threonine protein kinase
F3L20_RS03735	COG0515	serine threonine protein kinase
F3L20_RS03740	COG1012	belongs to the aldehyde dehydrogenase family
F3L20_RS03760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F3L20_RS03760	COG0519	Catalyzes the synthesis of GMP from XMP
F3L20_RS03805	COG2197	response regulator
F3L20_RS03810	COG0791	NLP P60 protein
F3L20_RS03835	COG0739	heme binding
F3L20_RS03845	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F3L20_RS03845	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F3L20_RS03860	COG0714	Associated with various cellular activities
F3L20_RS03870	COG3552	Protein containing von Willebrand factor type A (VWA) domain
F3L20_RS03880	COG0045	succinate-CoA ligase (ADP-forming) activity
F3L20_RS03910	COG0138	bifunctional purine biosynthesis protein purh
F3L20_RS03920	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F3L20_RS03935	COG0039	L-malate dehydrogenase activity
F3L20_RS03955	COG1012	belongs to the aldehyde dehydrogenase family
F3L20_RS03970	COG4176	ABC-type proline glycine betaine transport system permease component
F3L20_RS03980	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F3L20_RS03985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F3L20_RS03995	COG0754	glutathionylspermidine amidase activity
F3L20_RS04000	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F3L20_RS04020	COG0180	Tryptophanyl-tRNA synthetase
F3L20_RS04040	COG0671	phosphoesterase, PA-phosphatase related
F3L20_RS04060	COG1686	Belongs to the peptidase S11 family
F3L20_RS04070	COG1408	metallophosphoesterase
F3L20_RS04075	COG2205	protein histidine kinase activity
F3L20_RS04080	COG0745	RESPONSE REGULATOR receiver
F3L20_RS04085	COG2409	Drug exporters of the RND superfamily
F3L20_RS04115	COG2197	response regulator
F3L20_RS04130	COG1053	succinate dehydrogenase
F3L20_RS04140	COG2009	succinate dehydrogenase
F3L20_RS04150	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F3L20_RS04200	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F3L20_RS04200	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F3L20_RS04225	COG1216	Glycosyl transferase, family 2
F3L20_RS04240	COG1216	Glycosyl transferase, family 2
F3L20_RS04255	COG2089	acid synthase
F3L20_RS04265	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F3L20_RS04265	COG1473	amidohydrolase
F3L20_RS04270	COG1744	ABC transporter substrate-binding protein PnrA-like
F3L20_RS04275	COG1744	ABC transporter substrate-binding protein PnrA-like
F3L20_RS04280	COG3845	ABC transporter
F3L20_RS04285	COG4603	Belongs to the binding-protein-dependent transport system permease family
F3L20_RS04290	COG1079	Belongs to the binding-protein-dependent transport system permease family
F3L20_RS04320	COG2814	Major facilitator Superfamily
F3L20_RS04325	COG0583	DNA-binding transcription factor activity
F3L20_RS04335	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F3L20_RS04360	COG2205	protein histidine kinase activity
F3L20_RS04365	COG0745	RESPONSE REGULATOR receiver
F3L20_RS04370	COG1595	DNA-templated transcription, initiation
F3L20_RS04390	COG1012	belongs to the aldehyde dehydrogenase family
F3L20_RS04395	COG1012	belongs to the aldehyde dehydrogenase family
F3L20_RS04410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F3L20_RS04435	COG4770	biotin carboxylase activity
F3L20_RS04445	COG0424	maF-like protein
F3L20_RS04455	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F3L20_RS04465	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
F3L20_RS04470	COG1024	Enoyl-CoA hydratase
F3L20_RS04480	COG2986	histidine ammonia-lyase
F3L20_RS04500	COG1404	Belongs to the peptidase S8 family
F3L20_RS04510	COG1064	alcohol dehydrogenase
F3L20_RS04520	COG0515	serine threonine protein kinase
F3L20_RS04520	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F3L20_RS04545	COG2255	four-way junction helicase activity
F3L20_RS04550	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F3L20_RS04565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F3L20_RS04575	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F3L20_RS04590	COG1331	Highly conserved protein containing a thioredoxin domain
F3L20_RS04600	COG1309	transcriptional regulator
F3L20_RS04610	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
F3L20_RS04620	COG2267	carboxylic ester hydrolase activity
F3L20_RS04635	COG0436	Aminotransferase
F3L20_RS04650	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
F3L20_RS04665	COG1414	Transcriptional regulator
F3L20_RS04670	COG0251	oxidation-reduction process
F3L20_RS04675	COG2610	gluconate transmembrane transporter activity
F3L20_RS04720	COG2894	cell division
F3L20_RS04750	COG3920	Histidine kinase
F3L20_RS04755	COG2197	response regulator
F3L20_RS04810	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F3L20_RS04815	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
F3L20_RS04835	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F3L20_RS04840	COG0450	alkyl hydroperoxide reductase
F3L20_RS04855	COG1136	(ABC) transporter
F3L20_RS04875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F3L20_RS04890	COG0114	fumarate hydratase activity
F3L20_RS04900	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
F3L20_RS04900	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
F3L20_RS04925	COG0778	Nitroreductase
F3L20_RS04930	COG1722	exodeoxyribonuclease VII activity
F3L20_RS04945	COG1940	carbohydrate kinase activity
F3L20_RS04955	COG0012	GTP binding
F3L20_RS04960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F3L20_RS05015	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F3L20_RS05020	COG1053	succinate dehydrogenase
F3L20_RS05035	COG0747	negative chemotaxis
F3L20_RS05040	COG1217	gtp-binding protein TYPA
F3L20_RS05045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3L20_RS05050	COG0747	negative chemotaxis
F3L20_RS05060	COG0444	Belongs to the ABC transporter superfamily
F3L20_RS05065	COG4608	Belongs to the ABC transporter superfamily
F3L20_RS05075	COG0601	transmembrane transport
F3L20_RS05080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3L20_RS05085	COG0444	Belongs to the ABC transporter superfamily
F3L20_RS05090	COG4608	Belongs to the ABC transporter superfamily
F3L20_RS05105	COG0154	amidase activity
F3L20_RS05135	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F3L20_RS05155	COG1131	(ABC) transporter
F3L20_RS05165	COG4585	Histidine kinase
F3L20_RS05170	COG2197	response regulator
F3L20_RS05205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F3L20_RS05225	COG0519	Catalyzes the synthesis of GMP from XMP
F3L20_RS05230	COG1024	Enoyl-CoA hydratase
F3L20_RS05245	COG1595	DNA-templated transcription, initiation
F3L20_RS05255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F3L20_RS05260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F3L20_RS05295	COG0598	Magnesium transport protein CorA
F3L20_RS05305	COG2814	Major facilitator Superfamily
F3L20_RS05320	COG2095	MarC family integral membrane protein
F3L20_RS05325	COG1432	Conserved Protein
F3L20_RS05340	COG0513	Belongs to the DEAD box helicase family
F3L20_RS05410	COG0596	Alpha beta hydrolase
F3L20_RS05415	COG0596	Alpha beta hydrolase
F3L20_RS05435	COG0210	DNA helicase
F3L20_RS05445	COG2816	NAD+ diphosphatase activity
F3L20_RS05480	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F3L20_RS05530	COG3480	Lon protease (S16) C-terminal proteolytic domain
F3L20_RS05540	COG1615	UPF0182 protein
F3L20_RS05565	COG0753	catalase activity
F3L20_RS05575	COG0483	inositol monophosphate 1-phosphatase activity
F3L20_RS05585	COG2076	Multidrug Resistance protein
F3L20_RS05595	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F3L20_RS05605	COG2135	peptidase activity
F3L20_RS05615	COG1595	DNA-templated transcription, initiation
F3L20_RS05620	COG5662	AntiSigma factor
F3L20_RS05640	COG0242	peptide deformylase activity
F3L20_RS05650	COG2124	cytochrome p450
F3L20_RS05690	COG2188	Transcriptional regulator
F3L20_RS05695	COG0363	glucosamine-6-phosphate deaminase activity
F3L20_RS05710	COG1597	lipid kinase activity
F3L20_RS05750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F3L20_RS05755	COG0142	geranyltranstransferase activity
F3L20_RS05760	COG0456	acetyltransferase
F3L20_RS05790	COG4106	trans-aconitate 2-methyltransferase activity
F3L20_RS05795	COG1126	abc transporter atp-binding protein
F3L20_RS05800	COG0765	amino acid transport
F3L20_RS05815	COG0281	malic enzyme
F3L20_RS05820	COG0604	alcohol dehydrogenase
F3L20_RS05850	COG0508	dehydrogenase complex catalyzes the overall conversion of
F3L20_RS05850	COG0567	Dehydrogenase, E1 component
F3L20_RS05860	COG2205	protein histidine kinase activity
F3L20_RS05865	COG0745	RESPONSE REGULATOR receiver
F3L20_RS05875	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F3L20_RS05920	COG3883	PFAM NLP P60 protein
F3L20_RS05920	COG0791	NLP P60 protein
F3L20_RS05940	COG0768	penicillin binding
F3L20_RS05965	COG3285	dna ligase
F3L20_RS05965	COG1793	dna ligase
F3L20_RS05970	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
F3L20_RS05975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F3L20_RS05990	COG2197	response regulator
F3L20_RS05995	COG4585	Histidine kinase
F3L20_RS06005	COG0395	ABC-type sugar transport system, permease component
F3L20_RS06010	COG4209	transmembrane transport
F3L20_RS06015	COG1653	transport
F3L20_RS06020	COG4106	trans-aconitate 2-methyltransferase activity
F3L20_RS06050	COG0745	RESPONSE REGULATOR receiver
F3L20_RS06055	COG0018	arginyl-trna synthetase
F3L20_RS06060	COG0019	diaminopimelate decarboxylase activity
F3L20_RS06065	COG0460	homoserine dehydrogenase
F3L20_RS06070	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F3L20_RS06090	COG0254	rRNA binding
F3L20_RS06095	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F3L20_RS06100	COG2890	protein-(glutamine-N5) methyltransferase activity
F3L20_RS06110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F3L20_RS06120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F3L20_RS06135	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F3L20_RS06140	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F3L20_RS06145	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F3L20_RS06150	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F3L20_RS06155	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F3L20_RS06160	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F3L20_RS06165	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F3L20_RS06180	COG2197	response regulator
F3L20_RS06185	COG4585	Histidine kinase
F3L20_RS06195	COG4221	oxidoreductase activity
F3L20_RS06220	COG1250	3-hydroxyacyl-CoA dehydrogenase
F3L20_RS06235	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
F3L20_RS06290	COG0183	Belongs to the thiolase family
F3L20_RS06310	COG2205	protein histidine kinase activity
F3L20_RS06355	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F3L20_RS06355	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F3L20_RS06395	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F3L20_RS06400	COG0857	belongs to the CobB CobQ family
F3L20_RS06400	COG0280	phosphate acetyltransferase
F3L20_RS06405	COG0205	6-phosphofructokinase activity
F3L20_RS06415	COG4565	transcriptional regulatory protein
F3L20_RS06420	COG3290	protein histidine kinase activity
F3L20_RS06425	COG1301	dicarboxylic acid transport
F3L20_RS06445	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F3L20_RS06450	COG3281	Trehalose synthase
F3L20_RS06465	COG0058	SHG alpha-glucan phosphorylase activity
F3L20_RS06485	COG1132	(ABC) transporter
F3L20_RS06500	COG1132	(ABC) transporter
F3L20_RS06505	COG1132	(ABC) transporter
F3L20_RS06510	COG1131	(ABC) transporter
F3L20_RS06520	COG4585	Histidine kinase
F3L20_RS06525	COG2197	response regulator
F3L20_RS06560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F3L20_RS06565	COG3409	Peptidoglycan-binding domain 1 protein
F3L20_RS06565	COG3757	hydrolase, family 25
F3L20_RS06575	COG1760	l-serine dehydratase
F3L20_RS06580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F3L20_RS06585	COG0509	glycine decarboxylation via glycine cleavage system
F3L20_RS06590	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F3L20_RS06615	COG4166	transmembrane transport
F3L20_RS06625	COG0444	Belongs to the ABC transporter superfamily
F3L20_RS06635	COG2860	membrane
F3L20_RS06670	COG0482	sulfurtransferase activity
F3L20_RS06690	COG4221	oxidoreductase activity
F3L20_RS06700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F3L20_RS06710	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F3L20_RS06715	COG0154	amidase activity
F3L20_RS06725	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F3L20_RS06730	COG2226	methyltransferase
F3L20_RS06740	COG2409	Drug exporters of the RND superfamily
F3L20_RS06745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F3L20_RS06760	COG2197	response regulator
F3L20_RS06770	COG2133	pyrroloquinoline quinone binding
F3L20_RS06775	COG0667	Aldo Keto reductase
F3L20_RS06795	COG0440	acetolactate synthase activity
F3L20_RS06800	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F3L20_RS06805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F3L20_RS06810	COG0477	Major facilitator Superfamily
F3L20_RS06820	COG3835	regulator
F3L20_RS06825	COG0506	proline dehydrogenase activity
F3L20_RS06830	COG1012	belongs to the aldehyde dehydrogenase family
F3L20_RS06840	COG0473	3-isopropylmalate dehydrogenase activity
F3L20_RS06845	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F3L20_RS06855	COG0831	urea catabolic process
F3L20_RS06855	COG0832	Belongs to the urease beta subunit family
F3L20_RS06860	COG0804	urea catabolic process
F3L20_RS06865	COG2957	Belongs to the agmatine deiminase family
F3L20_RS06880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F3L20_RS06895	COG1032	radical SAM domain protein
F3L20_RS06900	COG0300	oxidoreductase activity
F3L20_RS06905	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F3L20_RS06925	COG2018	Roadblock/LC7 domain
F3L20_RS06945	COG2018	Roadblock/LC7 domain
F3L20_RS06950	COG5002	protein histidine kinase activity
F3L20_RS06960	COG0179	Fumarylacetoacetate (FAA) hydrolase
F3L20_RS06965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F3L20_RS07000	COG0789	Transcriptional regulator
F3L20_RS07005	COG1414	Transcriptional regulator
F3L20_RS07010	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F3L20_RS07015	COG0066	3-isopropylmalate dehydratase activity
F3L20_RS07025	COG0776	regulation of translation
F3L20_RS07035	COG1920	GTP binding
F3L20_RS07045	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F3L20_RS07050	COG1181	Belongs to the D-alanine--D-alanine ligase family
F3L20_RS07070	COG0351	phosphomethylpyrimidine kinase
F3L20_RS07075	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F3L20_RS07080	COG1461	Dihydroxyacetone kinase
F3L20_RS07090	COG0742	ribosomal rna small subunit methyltransferase
F3L20_RS07095	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F3L20_RS07110	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F3L20_RS07115	COG0571	ribonuclease III activity
F3L20_RS07120	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F3L20_RS07125	COG1733	regulation of RNA biosynthetic process
F3L20_RS07130	COG2340	Cysteine-rich secretory protein family
F3L20_RS07135	COG1254	Belongs to the acylphosphatase family
F3L20_RS07145	COG1196	nuclear chromosome segregation
F3L20_RS07150	COG0477	Major facilitator Superfamily
F3L20_RS07180	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
F3L20_RS07200	COG0228	four-way junction DNA binding
F3L20_RS07205	COG1837	Belongs to the UPF0109 family
F3L20_RS07210	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F3L20_RS07215	COG0336	Belongs to the RNA methyltransferase TrmD family
F3L20_RS07220	COG0335	large ribosomal subunit rRNA binding
F3L20_RS07235	COG0681	Belongs to the peptidase S26 family
F3L20_RS07255	COG0792	nuclease activity
F3L20_RS07285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F3L20_RS07300	COG1396	sequence-specific DNA binding
F3L20_RS07300	COG3800	Transcriptional regulator
F3L20_RS07350	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
F3L20_RS07355	COG1191	sigma factor activity
F3L20_RS07365	COG4942	peptidase
F3L20_RS07370	COG0052	Belongs to the universal ribosomal protein uS2 family
F3L20_RS07375	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F3L20_RS07380	COG0528	UMP kinase activity
F3L20_RS07385	COG0233	cytoplasmic translational termination
F3L20_RS07390	COG0575	Belongs to the CDS family
F3L20_RS07400	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F3L20_RS07410	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
F3L20_RS07415	COG3842	ATPase activity
F3L20_RS07440	COG1136	(ABC) transporter
F3L20_RS07445	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F3L20_RS07455	COG1012	belongs to the aldehyde dehydrogenase family
F3L20_RS07470	COG0584	glycerophosphoryl diester phosphodiesterase
F3L20_RS07475	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F3L20_RS07500	COG3842	ATPase activity
F3L20_RS07505	COG1176	ABC-type spermidine putrescine transport system, permease component I
F3L20_RS07510	COG1177	transmembrane transport
F3L20_RS07515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3L20_RS07540	COG2508	Transcriptional regulator
F3L20_RS07545	COG1012	belongs to the aldehyde dehydrogenase family
F3L20_RS07560	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F3L20_RS07565	COG0750	zinc metalloprotease
F3L20_RS07570	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F3L20_RS07585	COG0442	prolyl-tRNA aminoacylation
F3L20_RS07615	COG0779	Required for maturation of 30S ribosomal subunits
F3L20_RS07630	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F3L20_RS07640	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F3L20_RS07645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F3L20_RS07670	COG0444	Belongs to the ABC transporter superfamily
F3L20_RS07680	COG0601	transmembrane transport
F3L20_RS07685	COG0747	negative chemotaxis
F3L20_RS07690	COG0455	bacterial-type flagellum organization
F3L20_RS07705	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F3L20_RS07710	COG1185	polyribonucleotide nucleotidyltransferase activity
F3L20_RS07715	COG0612	Peptidase, M16
F3L20_RS07720	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F3L20_RS07740	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
F3L20_RS07745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F3L20_RS07750	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
F3L20_RS07795	COG4999	Histidine kinase
F3L20_RS07795	COG3437	response regulator, receiver
F3L20_RS07795	COG2205	protein histidine kinase activity
F3L20_RS07795	COG3850	Histidine kinase
F3L20_RS07805	COG1674	ftsk spoiiie
F3L20_RS07815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F3L20_RS07825	COG1546	Belongs to the CinA family
F3L20_RS07825	COG1058	Belongs to the CinA family
F3L20_RS07830	COG1396	sequence-specific DNA binding
F3L20_RS07835	COG0783	Belongs to the Dps family
F3L20_RS07845	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F3L20_RS07850	COG1201	RNA secondary structure unwinding
F3L20_RS07855	COG1917	Cupin 2, conserved barrel domain protein
F3L20_RS07855	COG2207	Transcriptional regulator
F3L20_RS07880	COG0628	permease
F3L20_RS07890	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F3L20_RS07900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F3L20_RS07915	COG0765	amino acid transport
F3L20_RS07920	COG0765	amino acid transport
F3L20_RS07925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3L20_RS07930	COG1126	abc transporter atp-binding protein
F3L20_RS07935	COG0745	RESPONSE REGULATOR receiver
F3L20_RS07940	COG2205	protein histidine kinase activity
F3L20_RS07945	COG2358	TRAP transporter, solute receptor (TAXI family
F3L20_RS07960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F3L20_RS07980	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F3L20_RS07990	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F3L20_RS07995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F3L20_RS08005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F3L20_RS08020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F3L20_RS08025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F3L20_RS08030	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F3L20_RS08050	COG0588	phosphoglycerate mutase activity
F3L20_RS08070	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F3L20_RS08105	COG1802	Transcriptional regulator
F3L20_RS08110	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F3L20_RS08125	COG0187	DNA topoisomerase II activity
F3L20_RS08135	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F3L20_RS08140	COG4565	transcriptional regulatory protein
F3L20_RS08145	COG3290	protein histidine kinase activity
F3L20_RS08170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F3L20_RS08175	COG0612	Peptidase, M16
F3L20_RS08190	COG1802	Transcriptional regulator
F3L20_RS08195	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F3L20_RS08220	COG1435	thymidine kinase activity
F3L20_RS08230	COG1733	regulation of RNA biosynthetic process
F3L20_RS08275	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F3L20_RS08295	COG1349	DNA-binding transcription factor activity
F3L20_RS08300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F3L20_RS08305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F3L20_RS08325	COG1802	Transcriptional regulator
F3L20_RS08340	COG1175	transmembrane transport
F3L20_RS08345	COG0395	ABC-type sugar transport system, permease component
F3L20_RS08370	COG3866	Pectate lyase
F3L20_RS08375	COG4677	pectinesterase activity
F3L20_RS08385	COG2252	PERMEase
F3L20_RS08390	COG0702	epimerase
F3L20_RS08400	COG0768	penicillin binding
F3L20_RS08410	COG1414	Transcriptional regulator
F3L20_RS08420	COG2197	response regulator
F3L20_RS08425	COG4585	Histidine kinase
F3L20_RS08445	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F3L20_RS08450	COG5285	phytanoyl-CoA dioxygenase
F3L20_RS08455	COG1917	Cupin 2, conserved barrel domain protein
F3L20_RS08460	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F3L20_RS08465	COG0456	acetyltransferase
F3L20_RS08470	COG2318	DinB family
F3L20_RS08475	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F3L20_RS08485	COG0765	amino acid transport
F3L20_RS08490	COG1126	abc transporter atp-binding protein
F3L20_RS08565	COG1492	cobalamin metabolic process
F3L20_RS08570	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
F3L20_RS08585	COG0235	Class ii aldolase
F3L20_RS08605	COG0488	(ABC) transporter
F3L20_RS08655	COG3387	PFAM Glycoside hydrolase 15-related
F3L20_RS08685	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F3L20_RS08695	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F3L20_RS08700	COG1404	Belongs to the peptidase S8 family
F3L20_RS08715	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F3L20_RS08720	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F3L20_RS08740	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F3L20_RS08755	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS08770	COG2186	Transcriptional regulator
F3L20_RS08790	COG0588	phosphoglycerate mutase activity
F3L20_RS08795	COG3830	Belongs to the UPF0237 family
F3L20_RS08795	COG0560	Phosphoserine phosphatase
F3L20_RS08805	COG1716	ATPase activity
F3L20_RS08805	COG1131	(ABC) transporter
F3L20_RS08805	COG0842	Transport permease protein
F3L20_RS08815	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F3L20_RS08825	COG4585	Histidine kinase
F3L20_RS08830	COG2197	response regulator
F3L20_RS08845	COG1119	ATPase activity
F3L20_RS08865	COG1881	PFAM PEBP family protein
F3L20_RS08875	COG2094	Belongs to the DNA glycosylase MPG family
F3L20_RS08910	COG0647	UMP catabolic process
F3L20_RS08915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F3L20_RS08920	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F3L20_RS08925	COG1120	ATPase activity
F3L20_RS08945	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F3L20_RS08950	COG0497	DNA recombination
F3L20_RS08955	COG0297	glycogen (starch) synthase activity
F3L20_RS08965	COG3387	PFAM Glycoside hydrolase 15-related
F3L20_RS08970	COG0504	CTP synthase activity
F3L20_RS08975	COG0494	nUDIX hydrolase
F3L20_RS08985	COG0686	Belongs to the AlaDH PNT family
F3L20_RS09000	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F3L20_RS09005	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F3L20_RS09010	COG1187	pseudouridine synthase activity
F3L20_RS09015	COG1056	cytidyltransferase-related domain
F3L20_RS09015	COG1051	belongs to the nudix hydrolase family
F3L20_RS09025	COG3541	Predicted nucleotidyltransferase
F3L20_RS09035	COG0723	plastoquinol--plastocyanin reductase activity
F3L20_RS09050	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F3L20_RS09060	COG1160	GTP binding
F3L20_RS09080	COG0671	phosphoesterase, PA-phosphatase related
F3L20_RS09090	COG0477	Major facilitator Superfamily
F3L20_RS09095	COG1960	acyl-CoA dehydrogenase activity
F3L20_RS09100	COG1799	cell septum assembly
F3L20_RS09125	COG0587	DNA-directed DNA polymerase activity
F3L20_RS09180	COG1725	Transcriptional regulator
F3L20_RS09195	COG2755	lipolytic protein G-D-S-L family
F3L20_RS09200	COG2815	serine threonine protein kinase
F3L20_RS09200	COG0515	serine threonine protein kinase
F3L20_RS09220	COG1595	DNA-templated transcription, initiation
F3L20_RS09260	COG2188	Transcriptional regulator
F3L20_RS09265	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
F3L20_RS09275	COG1309	transcriptional regulator
F3L20_RS09280	COG0243	molybdopterin cofactor binding
F3L20_RS09285	COG2851	Citrate transporter
F3L20_RS09330	COG0640	Transcriptional regulator
F3L20_RS09340	COG1960	acyl-CoA dehydrogenase activity
F3L20_RS09360	COG0789	Transcriptional regulator
F3L20_RS09375	COG3876	Protein conserved in bacteria
F3L20_RS09410	COG2149	membrane
F3L20_RS09415	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
F3L20_RS09450	COG2186	Transcriptional regulator
F3L20_RS09455	COG3012	SEC-C Motif Domain Protein
F3L20_RS09465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F3L20_RS09495	COG0667	Aldo Keto reductase
F3L20_RS09500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3L20_RS09510	COG0598	Magnesium transport protein CorA
F3L20_RS09530	COG0215	cysteine-tRNA ligase activity
F3L20_RS09540	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F3L20_RS09545	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F3L20_RS09550	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F3L20_RS09560	COG1410	methionine synthase
F3L20_RS09560	COG0646	methionine synthase
F3L20_RS09565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F3L20_RS09570	COG4166	transmembrane transport
F3L20_RS09575	COG4166	transmembrane transport
F3L20_RS09580	COG2197	response regulator
F3L20_RS09590	COG1994	Peptidase M50
F3L20_RS09590	COG0517	IMP dehydrogenase activity
F3L20_RS09615	COG1222	aaa ATPase
F3L20_RS09620	COG4122	O-methyltransferase activity
F3L20_RS09635	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F3L20_RS09640	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F3L20_RS09655	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F3L20_RS09660	COG0545	Peptidyl-prolyl cis-trans isomerase
F3L20_RS09690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F3L20_RS09695	COG0805	protein transport
F3L20_RS09745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F3L20_RS09750	COG4175	Glycine betaine
F3L20_RS09750	COG3448	diguanylate cyclase activity
F3L20_RS09755	COG4176	ABC-type proline glycine betaine transport system permease component
F3L20_RS09775	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F3L20_RS09780	COG0531	amino acid
F3L20_RS09845	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F3L20_RS09850	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F3L20_RS09855	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F3L20_RS09860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F3L20_RS09865	COG5002	protein histidine kinase activity
F3L20_RS09870	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F3L20_RS09875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F3L20_RS09875	COG0072	phenylalanine-tRNA ligase activity
F3L20_RS09900	COG1649	PFAM Uncharacterised BCR, COG1649
F3L20_RS09940	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F3L20_RS09945	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F3L20_RS09950	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F3L20_RS09955	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F3L20_RS09960	COG1438	arginine binding
F3L20_RS09995	COG0137	argininosuccinate synthase activity
F3L20_RS10000	COG0165	Argininosuccinate lyase
F3L20_RS10015	COG0477	Major facilitator Superfamily
F3L20_RS10020	COG0318	PFAM AMP-dependent synthetase and ligase
F3L20_RS10020	COG0204	Acyl-transferase
F3L20_RS10025	COG0584	glycerophosphoryl diester phosphodiesterase
F3L20_RS10055	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F3L20_RS10060	COG2011	ABC-type metal ion transport system permease component
F3L20_RS10065	COG1464	Belongs to the NlpA lipoprotein family
F3L20_RS10085	COG1648	precorrin-2 dehydrogenase activity
F3L20_RS10085	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F3L20_RS10145	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F3L20_RS10145	COG0512	Glutamine amidotransferase of anthranilate synthase
F3L20_RS10205	COG2176	DNA-directed DNA polymerase activity
F3L20_RS10205	COG5002	protein histidine kinase activity
F3L20_RS10220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F3L20_RS10240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F3L20_RS10245	COG1560	Kdo2-lipid A biosynthetic process
F3L20_RS10250	COG0438	transferase activity, transferring glycosyl groups
F3L20_RS10260	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
F3L20_RS10265	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
F3L20_RS10270	COG0217	transcriptional regulatory protein
F3L20_RS10275	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F3L20_RS10280	COG0632	four-way junction helicase activity
F3L20_RS10285	COG2255	four-way junction helicase activity
F3L20_RS10295	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F3L20_RS10300	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F3L20_RS10305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F3L20_RS10315	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F3L20_RS10320	COG1196	nuclear chromosome segregation
F3L20_RS10325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F3L20_RS10335	COG0124	histidyl-tRNA synthetase
F3L20_RS10350	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F3L20_RS10365	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F3L20_RS10370	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F3L20_RS10385	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F3L20_RS10395	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F3L20_RS10400	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F3L20_RS10405	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F3L20_RS10415	COG0006	proline dipeptidase activity
F3L20_RS10420	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F3L20_RS10425	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F3L20_RS10435	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
F3L20_RS10440	COG0540	Belongs to the ATCase OTCase family
F3L20_RS10445	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F3L20_RS10455	COG0505	Belongs to the CarA family
F3L20_RS10465	COG0167	dihydroorotate dehydrogenase activity
F3L20_RS10470	COG0284	orotidine-5'-phosphate decarboxylase activity
F3L20_RS10480	COG0194	GDP metabolic process
F3L20_RS10485	COG1758	RNA polymerase activity
F3L20_RS10495	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F3L20_RS10510	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F3L20_RS10520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F3L20_RS10525	COG2390	Transcriptional regulator
F3L20_RS10545	COG0531	amino acid
F3L20_RS10560	COG0726	polysaccharide deacetylase
F3L20_RS10570	COG1733	regulation of RNA biosynthetic process
F3L20_RS10580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F3L20_RS10600	COG2233	PERMEase
F3L20_RS10610	COG2223	nitrite transmembrane transporter activity
F3L20_RS10615	COG1846	Transcriptional regulator
F3L20_RS10615	COG1940	carbohydrate kinase activity
F3L20_RS10635	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F3L20_RS10635	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F3L20_RS10640	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F3L20_RS10645	COG0140	phosphoribosyl-ATP diphosphatase activity
F3L20_RS10650	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F3L20_RS10700	COG1960	acyl-CoA dehydrogenase activity
F3L20_RS10725	COG1216	Glycosyl transferase, family 2
F3L20_RS10730	COG3030	protein affecting phage T7 exclusion by the F plasmid
F3L20_RS10740	COG2270	Major facilitator Superfamily
F3L20_RS10750	COG2364	Membrane
F3L20_RS10755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F3L20_RS10780	COG1984	allophanate hydrolase subunit 2
F3L20_RS10785	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F3L20_RS10790	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F3L20_RS10795	COG4336	lyase activity
F3L20_RS10800	COG2814	Major facilitator Superfamily
F3L20_RS10825	COG1414	Transcriptional regulator
F3L20_RS10840	COG2018	Roadblock/LC7 domain
F3L20_RS10860	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F3L20_RS10865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F3L20_RS10870	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
F3L20_RS10885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F3L20_RS10895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F3L20_RS10930	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F3L20_RS10950	COG1716	ATPase activity
F3L20_RS10970	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F3L20_RS10980	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F3L20_RS10980	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F3L20_RS11000	COG3585	molybdate ion transport
F3L20_RS11065	COG0697	spore germination
F3L20_RS11110	COG4166	transmembrane transport
F3L20_RS11115	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F3L20_RS11130	COG2318	DinB family
F3L20_RS11155	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F3L20_RS11165	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS11175	COG1968	undecaprenyl-diphosphatase activity
F3L20_RS11185	COG0183	Belongs to the thiolase family
F3L20_RS11200	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F3L20_RS11235	COG0110	maltose O-acetyltransferase activity
F3L20_RS11255	COG1832	CoA-binding protein
F3L20_RS11270	COG1739	Uncharacterized protein family UPF0029
F3L20_RS11275	COG0420	3'-5' exonuclease activity
F3L20_RS11280	COG0419	ATPase involved in DNA repair
F3L20_RS11285	COG1522	sequence-specific DNA binding
F3L20_RS11300	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS11315	COG0626	cystathionine gamma-synthase activity
F3L20_RS11350	COG0596	Alpha beta hydrolase
F3L20_RS11355	COG1595	DNA-templated transcription, initiation
F3L20_RS11360	COG2188	Transcriptional regulator
F3L20_RS11365	COG1940	carbohydrate kinase activity
F3L20_RS11390	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F3L20_RS11415	COG0577	efflux transmembrane transporter activity
F3L20_RS11415	COG1136	(ABC) transporter
F3L20_RS11435	COG2226	methyltransferase
F3L20_RS11440	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F3L20_RS11445	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F3L20_RS11450	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F3L20_RS11485	COG0740	serine-type endopeptidase activity
F3L20_RS11500	COG1309	transcriptional regulator
F3L20_RS11505	COG0831	urea catabolic process
F3L20_RS11510	COG0832	Belongs to the urease beta subunit family
F3L20_RS11515	COG0804	urea catabolic process
F3L20_RS11525	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F3L20_RS11530	COG0829	nickel cation binding
F3L20_RS11540	COG0204	Acyl-transferase
F3L20_RS11560	COG0745	RESPONSE REGULATOR receiver
F3L20_RS11565	COG2205	protein histidine kinase activity
F3L20_RS11590	COG0756	dUTP diphosphatase activity
F3L20_RS11610	COG1136	(ABC) transporter
F3L20_RS11640	COG0569	domain protein
F3L20_RS11645	COG0531	amino acid
F3L20_RS11650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F3L20_RS11745	COG0028	Belongs to the TPP enzyme family
F3L20_RS11750	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS11775	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F3L20_RS11790	COG1215	transferase activity, transferring glycosyl groups
F3L20_RS11850	COG0367	asparagine synthase
F3L20_RS11870	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F3L20_RS11880	COG2318	DinB family
F3L20_RS11885	COG3340	Belongs to the peptidase S51 family
F3L20_RS11890	COG2188	Transcriptional regulator
F3L20_RS11895	COG2182	Extracellular solute-binding protein
F3L20_RS11900	COG1175	transmembrane transport
F3L20_RS11905	COG0395	ABC-type sugar transport system, permease component
F3L20_RS11910	COG1472	Belongs to the glycosyl hydrolase 3 family
F3L20_RS11920	COG1799	cell septum assembly
F3L20_RS11955	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F3L20_RS11960	COG2235	arginine
F3L20_RS11965	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F3L20_RS11975	COG1024	Enoyl-CoA hydratase
F3L20_RS12035	COG2255	four-way junction helicase activity
F3L20_RS12040	COG2755	lipolytic protein G-D-S-L family
F3L20_RS12050	COG0583	DNA-binding transcription factor activity
F3L20_RS12060	COG0738	Major facilitator superfamily
F3L20_RS12065	COG3226	Transcriptional regulator
F3L20_RS12070	COG1122	ATPase activity
F3L20_RS12080	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
F3L20_RS12085	COG0310	cobalt ion transport
F3L20_RS12095	COG0601	transmembrane transport
F3L20_RS12100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3L20_RS12110	COG0444	Belongs to the ABC transporter superfamily
F3L20_RS12115	COG1124	(ABC) transporter
F3L20_RS12135	COG2311	Membrane
F3L20_RS12165	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F3L20_RS12180	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F3L20_RS12190	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F3L20_RS12215	COG1653	transport
F3L20_RS12220	COG1175	transmembrane transport
F3L20_RS12225	COG0395	ABC-type sugar transport system, permease component
F3L20_RS12230	COG1940	carbohydrate kinase activity
F3L20_RS12235	COG4213	ABC transporter substrate-binding protein
F3L20_RS12245	COG4214	carbohydrate transport
F3L20_RS12250	COG1280	lysine exporter protein (LysE YggA)
F3L20_RS12255	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F3L20_RS12260	COG0531	amino acid
F3L20_RS12275	COG1316	TRANSCRIPTIONal
F3L20_RS12285	COG0438	transferase activity, transferring glycosyl groups
F3L20_RS12295	COG0438	transferase activity, transferring glycosyl groups
F3L20_RS12305	COG1250	3-hydroxyacyl-CoA dehydrogenase
F3L20_RS12305	COG1024	Enoyl-CoA hydratase
F3L20_RS12310	COG0183	Belongs to the thiolase family
F3L20_RS12325	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
F3L20_RS12340	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F3L20_RS12345	COG2182	Extracellular solute-binding protein
F3L20_RS12350	COG1175	transmembrane transport
F3L20_RS12355	COG0395	ABC-type sugar transport system, permease component
F3L20_RS12370	COG3507	Belongs to the glycosyl hydrolase 43 family
F3L20_RS12385	COG0446	pyridine nucleotide-disulphide oxidoreductase
F3L20_RS12395	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
F3L20_RS12400	COG3253	May function as heme-dependent peroxidase
F3L20_RS12420	COG3220	belongs to the UPF0276 family
F3L20_RS12455	COG0723	plastoquinol--plastocyanin reductase activity
F3L20_RS12455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3L20_RS12485	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F3L20_RS12490	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F3L20_RS12530	COG0745	RESPONSE REGULATOR receiver
F3L20_RS12535	COG5002	protein histidine kinase activity
F3L20_RS12545	COG2205	protein histidine kinase activity
F3L20_RS12550	COG0745	RESPONSE REGULATOR receiver
F3L20_RS12560	COG1174	glycine betaine transport
F3L20_RS12565	COG1174	glycine betaine transport
F3L20_RS12620	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F3L20_RS12715	COG1116	anion transmembrane transporter activity
F3L20_RS12735	COG0529	Catalyzes the synthesis of activated sulfate
F3L20_RS12740	COG0175	sulfate reduction
F3L20_RS12770	COG1960	acyl-CoA dehydrogenase activity
F3L20_RS12785	COG4977	sequence-specific DNA binding
F3L20_RS12785	COG1917	Cupin 2, conserved barrel domain protein
F3L20_RS12815	COG0583	DNA-binding transcription factor activity
F3L20_RS12855	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F3L20_RS12860	COG2040	homocysteine
F3L20_RS12895	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F3L20_RS12920	COG0277	FAD linked oxidase domain protein
F3L20_RS12945	COG1162	GTPase activity
F3L20_RS12965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F3L20_RS12980	COG0028	Belongs to the TPP enzyme family
F3L20_RS13040	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F3L20_RS13045	COG2252	PERMEase
F3L20_RS13080	COG0859	PFAM glycosyl transferase family 9
F3L20_RS13125	COG2197	response regulator
F3L20_RS13130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F3L20_RS13135	COG0318	PFAM AMP-dependent synthetase and ligase
F3L20_RS13140	COG0583	DNA-binding transcription factor activity
F3L20_RS13145	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS13165	COG3960	tartronate-semialdehyde synthase activity
F3L20_RS13180	COG2084	Dehydrogenase
F3L20_RS13185	COG3622	Belongs to the hyi family
F3L20_RS13205	COG2351	hydroxyisourate hydrolase activity
F3L20_RS13220	COG2233	PERMEase
F3L20_RS13295	COG0436	Aminotransferase
F3L20_RS13300	COG1733	regulation of RNA biosynthetic process
F3L20_RS13350	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F3L20_RS13365	COG1414	Transcriptional regulator
F3L20_RS13370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F3L20_RS13375	COG4266	Belongs to the allantoicase family
F3L20_RS13400	COG2197	response regulator
F3L20_RS13415	COG2188	Transcriptional regulator
F3L20_RS13420	COG1940	carbohydrate kinase activity
F3L20_RS13430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F3L20_RS13465	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F3L20_RS13470	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F3L20_RS13475	COG0708	Exodeoxyribonuclease III
F3L20_RS13490	COG0405	Gamma-glutamyltransferase
F3L20_RS13520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F3L20_RS13535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F3L20_RS13540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3L20_RS13545	COG1953	Uracil, thiamine, allantoin
F3L20_RS13570	COG0444	Belongs to the ABC transporter superfamily
F3L20_RS13580	COG0747	negative chemotaxis
F3L20_RS13590	COG3458	cephalosporin-C deacetylase activity
F3L20_RS13600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F3L20_RS13610	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
F3L20_RS13615	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F3L20_RS13615	COG3291	Pkd domain containing protein
F3L20_RS13625	COG0483	inositol monophosphate 1-phosphatase activity
F3L20_RS13635	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
F3L20_RS13660	COG3263	regulation of cellular component size
F3L20_RS13685	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F3L20_RS13710	COG0688	phosphatidylethanolamine metabolic process
F3L20_RS13730	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F3L20_RS13730	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F3L20_RS13735	COG0604	alcohol dehydrogenase
F3L20_RS13745	COG1250	3-hydroxyacyl-CoA dehydrogenase
F3L20_RS13820	COG2362	D-Aminopeptidase
F3L20_RS13825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F3L20_RS13835	COG1619	proteins homologs of microcin C7 resistance protein MccF
F3L20_RS13860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3L20_RS13870	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F3L20_RS13875	COG3285	dna ligase
F3L20_RS13875	COG1793	dna ligase
F3L20_RS13935	COG0488	(ABC) transporter
F3L20_RS13950	COG0693	protein deglycase activity
F3L20_RS14030	COG0443	Heat shock 70 kDa protein
F3L20_RS14050	COG2154	pterin-4-alpha-carbinolamine dehydratase
F3L20_RS14060	COG4733	cellulase activity
F3L20_RS14060	COG5297	Belongs to the glycosyl hydrolase family 6
F3L20_RS14065	COG5297	Belongs to the glycosyl hydrolase family 6
F3L20_RS14080	COG0656	L-ascorbic acid biosynthetic process
F3L20_RS14090	COG0583	DNA-binding transcription factor activity
F3L20_RS14100	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F3L20_RS14115	COG3383	formate dehydrogenase (NAD+) activity
F3L20_RS14120	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F3L20_RS14130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F3L20_RS14145	COG1129	ABC transporter
F3L20_RS14150	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3L20_RS14215	COG2223	nitrite transmembrane transporter activity
F3L20_RS14225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F3L20_RS14235	COG0045	succinate-CoA ligase (ADP-forming) activity
F3L20_RS14245	COG1012	belongs to the aldehyde dehydrogenase family
F3L20_RS14305	COG0477	Major facilitator Superfamily
F3L20_RS14310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F3L20_RS14315	COG2182	Extracellular solute-binding protein
F3L20_RS14320	COG1175	transmembrane transport
F3L20_RS14325	COG0395	ABC-type sugar transport system, permease component
F3L20_RS14330	COG2723	6-phospho-beta-galactosidase activity
F3L20_RS14340	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS14355	COG0714	Associated with various cellular activities
F3L20_RS14360	COG3552	Protein containing von Willebrand factor type A (VWA) domain
F3L20_RS14375	COG5434	Belongs to the glycosyl hydrolase 28 family
F3L20_RS14375	COG4632	Exopolysaccharide biosynthesis protein
F3L20_RS14450	COG1846	Transcriptional regulator
F3L20_RS14475	COG1012	belongs to the aldehyde dehydrogenase family
F3L20_RS14485	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F3L20_RS14515	COG0297	glycogen (starch) synthase activity
F3L20_RS14535	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F3L20_RS14545	COG3467	pyridoxamine 5'-phosphate
F3L20_RS14550	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F3L20_RS14555	COG0406	alpha-ribazole phosphatase activity
F3L20_RS14560	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
F3L20_RS14580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F3L20_RS14600	COG1486	melibiose metabolic process
F3L20_RS14640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3L20_RS14660	COG3938	Belongs to the proline racemase family
F3L20_RS14680	COG1175	transmembrane transport
F3L20_RS14685	COG0395	ABC-type sugar transport system, permease component
F3L20_RS14690	COG0366	Alpha amylase catalytic
F3L20_RS14700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F3L20_RS14730	COG0745	RESPONSE REGULATOR receiver
F3L20_RS14740	COG0435	Glutathione S-transferase
F3L20_RS14765	COG1672	PFAM Archaeal ATPase
F3L20_RS14765	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
F3L20_RS14770	COG1470	cell adhesion involved in biofilm formation
F3L20_RS14780	COG1793	dna ligase
F3L20_RS14825	COG1834	amidinotransferase
F3L20_RS14830	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F3L20_RS14835	COG0488	(ABC) transporter
F3L20_RS14860	COG1515	deoxyribonuclease V activity
F3L20_RS14870	COG3268	Saccharopine dehydrogenase
F3L20_RS14880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F3L20_RS14885	COG0183	Belongs to the thiolase family
F3L20_RS14890	COG1250	3-hydroxyacyl-CoA dehydrogenase
F3L20_RS14890	COG1024	Enoyl-CoA hydratase
F3L20_RS14900	COG1113	amino acid transport
F3L20_RS14910	COG2936	dipeptidyl-peptidase activity
F3L20_RS14920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F3L20_RS14935	COG0488	(ABC) transporter
F3L20_RS14945	COG1024	Enoyl-CoA hydratase
F3L20_RS14960	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
F3L20_RS15005	COG1134	teichoic acid transport
F3L20_RS15005	COG1388	LysM domain
F3L20_RS15010	COG1562	ergosterol biosynthetic process
F3L20_RS15020	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
F3L20_RS15030	COG1657	PFAM Prenyltransferase squalene oxidase
F3L20_RS15050	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F3L20_RS15070	COG2365	Tyrosine phosphatase family
F3L20_RS15080	COG2755	lipolytic protein G-D-S-L family
F3L20_RS15095	COG1278	Cold shock
F3L20_RS15100	COG0513	Belongs to the DEAD box helicase family
F3L20_RS15115	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
F3L20_RS15120	COG2814	Major facilitator Superfamily
F3L20_RS15120	COG0477	Major facilitator Superfamily
F3L20_RS15135	COG2159	amidohydrolase
F3L20_RS15175	COG1063	alcohol dehydrogenase
F3L20_RS15180	COG0156	8-amino-7-oxononanoate synthase activity
F3L20_RS15185	COG0583	DNA-binding transcription factor activity
F3L20_RS15190	COG1309	transcriptional regulator
F3L20_RS15220	COG3959	Transketolase, thiamine diphosphate binding domain
F3L20_RS15280	COG0183	Belongs to the thiolase family
F3L20_RS15320	COG2188	Transcriptional regulator
F3L20_RS15325	COG3962	Belongs to the TPP enzyme family
F3L20_RS15330	COG3718	enzyme involved in inositol metabolism
F3L20_RS15340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F3L20_RS15360	COG1312	Catalyzes the dehydration of D-mannonate
F3L20_RS15365	COG0673	inositol 2-dehydrogenase activity
F3L20_RS15395	COG0673	inositol 2-dehydrogenase activity
F3L20_RS15400	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS15415	COG3548	integral membrane protein
F3L20_RS15420	COG0673	inositol 2-dehydrogenase activity
F3L20_RS15430	COG3467	pyridoxamine 5'-phosphate
F3L20_RS15470	COG2838	Isocitrate dehydrogenase
F3L20_RS15475	COG0668	transmembrane transport
F3L20_RS15480	COG1024	Enoyl-CoA hydratase
F3L20_RS15490	COG1132	(ABC) transporter
F3L20_RS15495	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F3L20_RS15495	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F3L20_RS15505	COG2197	response regulator
F3L20_RS15510	COG3851	Histidine kinase
F3L20_RS15560	COG1653	transport
F3L20_RS15565	COG1175	transmembrane transport
F3L20_RS15575	COG1472	Belongs to the glycosyl hydrolase 3 family
F3L20_RS15620	COG0513	Belongs to the DEAD box helicase family
F3L20_RS15640	COG1595	DNA-templated transcription, initiation
F3L20_RS15655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F3L20_RS15665	COG0431	NADPH-dependent FMN reductase
F3L20_RS15670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3L20_RS15700	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS15705	COG1309	transcriptional regulator
F3L20_RS15725	COG3971	2-oxopent-4-enoate hydratase activity
F3L20_RS15745	COG0577	efflux transmembrane transporter activity
F3L20_RS15750	COG1136	(ABC) transporter
F3L20_RS15760	COG3693	PFAM glycoside hydrolase, family 10
F3L20_RS15770	COG1472	Belongs to the glycosyl hydrolase 3 family
F3L20_RS15780	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
F3L20_RS15785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F3L20_RS15790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F3L20_RS15800	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F3L20_RS15815	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F3L20_RS15835	COG0297	glycogen (starch) synthase activity
F3L20_RS15840	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F3L20_RS15875	COG0300	oxidoreductase activity
F3L20_RS15895	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F3L20_RS15900	COG3320	Male sterility
F3L20_RS15900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F3L20_RS15910	COG1132	(ABC) transporter
F3L20_RS15915	COG2375	cellular response to nickel ion
F3L20_RS15915	COG1132	(ABC) transporter
F3L20_RS15920	COG2409	Drug exporters of the RND superfamily
F3L20_RS15970	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
F3L20_RS15980	COG1535	isochorismatase
F3L20_RS15980	COG3433	isochorismatase activity
F3L20_RS15985	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS15990	COG1228	amidohydrolase
F3L20_RS16000	COG1021	2,3-dihydroxybenzoate-AMP ligase
F3L20_RS16025	COG0477	Major facilitator Superfamily
F3L20_RS16070	COG1960	acyl-CoA dehydrogenase activity
F3L20_RS16085	COG3903	Transcriptional regulator
F3L20_RS16085	COG3629	intracellular signal transduction
F3L20_RS16120	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F3L20_RS16165	COG0531	amino acid
F3L20_RS16175	COG0726	polysaccharide deacetylase
F3L20_RS16225	COG0583	DNA-binding transcription factor activity
F3L20_RS16235	COG1053	succinate dehydrogenase
F3L20_RS16240	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F3L20_RS16250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3L20_RS16260	COG3360	Dodecin
F3L20_RS16270	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
F3L20_RS16275	COG0121	glutamine amidotransferase
F3L20_RS16280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F3L20_RS16305	COG1335	isochorismatase
F3L20_RS16315	COG1309	transcriptional regulator
F3L20_RS16320	COG4221	oxidoreductase activity
F3L20_RS16335	COG0517	IMP dehydrogenase activity
F3L20_RS16350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F3L20_RS16360	COG0583	DNA-binding transcription factor activity
F3L20_RS16370	COG2080	2 iron, 2 sulfur cluster binding
F3L20_RS16375	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
F3L20_RS16380	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F3L20_RS16400	COG1609	Transcriptional regulator
F3L20_RS16410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F3L20_RS16455	COG0542	response to heat
F3L20_RS16465	COG1136	(ABC) transporter
F3L20_RS16465	COG0577	efflux transmembrane transporter activity
F3L20_RS16470	COG1556	Lactate utilization protein
F3L20_RS16475	COG1139	Iron-sulfur cluster binding protein
F3L20_RS16480	COG0247	lactate metabolic process
F3L20_RS16485	COG1070	Carbohydrate kinase
F3L20_RS16490	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS16490	COG3347	Dehydrogenase
F3L20_RS16500	COG1129	ABC transporter
F3L20_RS16525	COG1609	Transcriptional regulator
F3L20_RS16540	COG1595	DNA-templated transcription, initiation
F3L20_RS16560	COG1309	transcriptional regulator
F3L20_RS16570	COG2706	6-phosphogluconolactonase activity
F3L20_RS16610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F3L20_RS16615	COG1796	DNA polymerase
F3L20_RS16615	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F3L20_RS16620	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS16655	COG0435	Glutathione S-transferase
F3L20_RS16685	COG0667	Aldo Keto reductase
F3L20_RS16745	COG0248	Ppx GppA phosphatase
F3L20_RS16760	COG2274	protein secretion by the type I secretion system
F3L20_RS16765	COG2274	protein secretion by the type I secretion system
F3L20_RS16795	COG0517	IMP dehydrogenase activity
F3L20_RS16820	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
F3L20_RS16850	COG4221	oxidoreductase activity
F3L20_RS16860	COG0583	DNA-binding transcription factor activity
F3L20_RS16870	COG1132	(ABC) transporter
F3L20_RS16885	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS16915	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
F3L20_RS16920	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
F3L20_RS16940	COG0745	RESPONSE REGULATOR receiver
F3L20_RS16945	COG2205	protein histidine kinase activity
F3L20_RS16950	COG1686	Belongs to the peptidase S11 family
F3L20_RS17010	COG1554	hydrolase, family 65, central catalytic
F3L20_RS17035	COG0673	inositol 2-dehydrogenase activity
F3L20_RS17040	COG2764	glyoxalase bleomycin resistance protein dioxygenase
F3L20_RS17045	COG0667	Aldo Keto reductase
F3L20_RS17050	COG1132	(ABC) transporter
F3L20_RS17195	COG2508	Transcriptional regulator
F3L20_RS17200	COG0410	ABC transporter
F3L20_RS17210	COG0559	Belongs to the binding-protein-dependent transport system permease family
F3L20_RS17230	COG0667	Aldo Keto reductase
F3L20_RS17270	COG0326	Molecular chaperone. Has ATPase activity
F3L20_RS17280	COG2084	Dehydrogenase
F3L20_RS17285	COG0596	Alpha beta hydrolase
F3L20_RS17300	COG2308	Evidence 4 Homologs of previously reported genes of
F3L20_RS17300	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F3L20_RS17325	COG1846	Transcriptional regulator
F3L20_RS17325	COG1940	carbohydrate kinase activity
F3L20_RS17335	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F3L20_RS17365	COG1120	ATPase activity
F3L20_RS17410	COG0395	ABC-type sugar transport system, permease component
F3L20_RS17415	COG4209	transmembrane transport
F3L20_RS17420	COG1609	Transcriptional regulator
F3L20_RS17445	COG0513	Belongs to the DEAD box helicase family
F3L20_RS17465	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS17470	COG2326	polyphosphate kinase activity
F3L20_RS17475	COG1501	Belongs to the glycosyl hydrolase 31 family
F3L20_RS17490	COG0395	ABC-type sugar transport system, permease component
F3L20_RS17495	COG2723	6-phospho-beta-galactosidase activity
F3L20_RS17510	COG3537	Alpha-1,2-mannosidase
F3L20_RS17515	COG5297	Belongs to the glycosyl hydrolase family 6
F3L20_RS17515	COG4447	cellulose binding
F3L20_RS17520	COG2188	Transcriptional regulator
F3L20_RS17600	COG0346	lactoylglutathione lyase activity
F3L20_RS17605	COG0640	Transcriptional regulator
F3L20_RS17610	COG2259	Doxx family
F3L20_RS17620	COG0488	(ABC) transporter
F3L20_RS17695	COG4978	Transcriptional regulator
F3L20_RS17695	COG0789	Transcriptional regulator
F3L20_RS17725	COG0395	ABC-type sugar transport system, permease component
F3L20_RS17750	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F3L20_RS17790	COG1733	regulation of RNA biosynthetic process
F3L20_RS17805	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F3L20_RS17830	COG2318	DinB family
F3L20_RS17840	COG1396	sequence-specific DNA binding
F3L20_RS17860	COG4941	Belongs to the sigma-70 factor family
F3L20_RS17865	COG3795	YCII-related domain
F3L20_RS17870	COG0475	glutathione-regulated potassium exporter activity
F3L20_RS17875	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F3L20_RS17900	COG0596	Alpha beta hydrolase
F3L20_RS17930	COG0531	amino acid
F3L20_RS17980	COG0110	maltose O-acetyltransferase activity
F3L20_RS17990	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F3L20_RS18025	COG1733	regulation of RNA biosynthetic process
F3L20_RS18040	COG2226	methyltransferase
F3L20_RS18060	COG2045	Belongs to the ComB family
F3L20_RS18100	COG1846	Transcriptional regulator
F3L20_RS18105	COG2409	Drug exporters of the RND superfamily
F3L20_RS18120	COG2814	Major facilitator Superfamily
F3L20_RS18135	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F3L20_RS18140	COG0395	ABC-type sugar transport system, permease component
F3L20_RS18155	COG1349	DNA-binding transcription factor activity
F3L20_RS18170	COG2814	Major facilitator Superfamily
F3L20_RS18180	COG1619	proteins homologs of microcin C7 resistance protein MccF
F3L20_RS18210	COG3708	Transcriptional regulator
F3L20_RS18210	COG2207	Transcriptional regulator
F3L20_RS18220	COG1309	transcriptional regulator
F3L20_RS18270	COG0789	Transcriptional regulator
F3L20_RS18275	COG0739	heme binding
F3L20_RS18285	COG0584	glycerophosphoryl diester phosphodiesterase
F3L20_RS18295	COG1595	DNA-templated transcription, initiation
F3L20_RS18305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F3L20_RS18320	COG1309	transcriptional regulator
F3L20_RS18325	COG0488	(ABC) transporter
F3L20_RS18360	COG2197	response regulator
F3L20_RS18365	COG4585	Histidine kinase
F3L20_RS18390	COG1349	DNA-binding transcription factor activity
F3L20_RS18395	COG2223	nitrite transmembrane transporter activity
F3L20_RS18400	COG1595	DNA-templated transcription, initiation
F3L20_RS18490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F3L20_RS18500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F3L20_RS18505	COG1937	Protein conserved in bacteria
F3L20_RS18530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F3L20_RS18555	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F3L20_RS18560	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
F3L20_RS18565	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
F3L20_RS18580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F3L20_RS18585	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F3L20_RS18590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F3L20_RS18595	COG0640	Transcriptional regulator
F3L20_RS18610	COG1120	ATPase activity
F3L20_RS18615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F3L20_RS18650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F3L20_RS18655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F3L20_RS18660	COG1120	ATPase activity
F3L20_RS18685	COG1132	(ABC) transporter
F3L20_RS18690	COG1132	(ABC) transporter
F3L20_RS18700	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F3L20_RS18705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F3L20_RS18715	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F3L20_RS18725	COG0254	rRNA binding
F3L20_RS18730	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F3L20_RS18735	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F3L20_RS18740	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F3L20_RS18745	COG0789	Transcriptional regulator
F3L20_RS18755	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS18770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F3L20_RS18785	COG0604	alcohol dehydrogenase
F3L20_RS18810	COG3396	Phenylacetate-CoA oxygenase
F3L20_RS18820	COG3396	Phenylacetate-CoA oxygenase
F3L20_RS18825	COG2151	metal-sulfur cluster biosynthetic enzyme
F3L20_RS18830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F3L20_RS18840	COG3483	tryptophan 2,3-dioxygenase activity
F3L20_RS18850	COG3844	kynureninase activity
F3L20_RS18870	COG0501	Belongs to the peptidase M48B family
F3L20_RS18880	COG0488	(ABC) transporter
F3L20_RS18905	COG0442	prolyl-tRNA aminoacylation
F3L20_RS18935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F3L20_RS18945	COG0798	PFAM Bile acid sodium symporter
F3L20_RS18950	COG2072	flavoprotein involved in K transport
F3L20_RS18955	COG0640	Transcriptional regulator
F3L20_RS18975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F3L20_RS19090	COG2197	response regulator
F3L20_RS19110	COG0515	serine threonine protein kinase
F3L20_RS19125	COG0583	DNA-binding transcription factor activity
F3L20_RS19140	COG3511	phospholipase C
F3L20_RS19160	COG3647	Membrane
F3L20_RS19175	COG1309	transcriptional regulator
F3L20_RS19180	COG1064	alcohol dehydrogenase
F3L20_RS19215	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F3L20_RS19280	COG0584	glycerophosphoryl diester phosphodiesterase
F3L20_RS19305	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F3L20_RS19310	COG1993	acr, cog1993
F3L20_RS19315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F3L20_RS19325	COG0659	secondary active sulfate transmembrane transporter activity
F3L20_RS19330	COG0583	DNA-binding transcription factor activity
F3L20_RS19375	COG4977	sequence-specific DNA binding
F3L20_RS19385	COG0514	ATP-dependent DNA helicase (RecQ)
F3L20_RS19425	COG0726	polysaccharide deacetylase
F3L20_RS19440	COG2197	response regulator
F3L20_RS19460	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
F3L20_RS19490	COG0488	(ABC) transporter
F3L20_RS19500	COG3250	beta-galactosidase activity
F3L20_RS19520	COG3250	beta-galactosidase activity
F3L20_RS19525	COG1940	carbohydrate kinase activity
F3L20_RS19525	COG1846	Transcriptional regulator
F3L20_RS19535	COG1175	transmembrane transport
F3L20_RS19545	COG3345	alpha-galactosidase
F3L20_RS19575	COG1309	transcriptional regulator
F3L20_RS19580	COG2755	lipolytic protein G-D-S-L family
F3L20_RS19590	COG0277	FAD linked oxidase domain protein
F3L20_RS19615	COG4608	Belongs to the ABC transporter superfamily
F3L20_RS19620	COG0444	Belongs to the ABC transporter superfamily
F3L20_RS19625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3L20_RS19630	COG0601	transmembrane transport
F3L20_RS19635	COG0747	negative chemotaxis
F3L20_RS19645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F3L20_RS19650	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS19660	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F3L20_RS19690	COG3386	PFAM SMP-30 Gluconolaconase
F3L20_RS19705	COG4948	Mandelate Racemase Muconate Lactonizing
F3L20_RS19710	COG2186	Transcriptional regulator
F3L20_RS19725	COG0395	ABC-type sugar transport system, permease component
F3L20_RS19730	COG1175	transmembrane transport
F3L20_RS19740	COG3345	alpha-galactosidase
F3L20_RS19750	COG0789	Transcriptional regulator
F3L20_RS19765	COG4585	Histidine kinase
F3L20_RS19770	COG0586	Pfam SNARE associated Golgi protein
F3L20_RS19815	COG2258	MOSC domain
F3L20_RS19820	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS19825	COG2318	DinB family
F3L20_RS19875	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS19880	COG1309	transcriptional regulator
F3L20_RS19990	COG1309	transcriptional regulator
F3L20_RS20010	COG0702	epimerase
F3L20_RS20015	COG0142	geranyltranstransferase activity
F3L20_RS20020	COG0783	Belongs to the Dps family
F3L20_RS20055	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F3L20_RS20070	COG1366	Belongs to the anti-sigma-factor antagonist family
F3L20_RS20095	COG2267	carboxylic ester hydrolase activity
F3L20_RS20110	COG1755	Isoprenylcysteine carboxyl methyltransferase
F3L20_RS20125	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F3L20_RS20140	COG4221	oxidoreductase activity
F3L20_RS20150	COG0726	polysaccharide deacetylase
F3L20_RS20185	COG0395	ABC-type sugar transport system, permease component
F3L20_RS20190	COG1175	transmembrane transport
F3L20_RS20225	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F3L20_RS20230	COG0254	rRNA binding
F3L20_RS20235	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F3L20_RS20300	COG0667	Aldo Keto reductase
F3L20_RS20325	COG0657	acetylesterase activity
F3L20_RS20345	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
F3L20_RS20355	COG2186	Transcriptional regulator
F3L20_RS20360	COG0129	dihydroxy-acid dehydratase activity
F3L20_RS20370	COG1472	Belongs to the glycosyl hydrolase 3 family
F3L20_RS20380	COG1175	transmembrane transport
F3L20_RS20390	COG1609	Transcriptional regulator
F3L20_RS20395	COG2205	protein histidine kinase activity
F3L20_RS20400	COG0745	RESPONSE REGULATOR receiver
F3L20_RS20415	COG0829	nickel cation binding
F3L20_RS20420	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F3L20_RS20430	COG0804	urea catabolic process
F3L20_RS20435	COG0832	Belongs to the urease beta subunit family
F3L20_RS20435	COG0831	urea catabolic process
F3L20_RS20455	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F3L20_RS20460	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F3L20_RS20490	COG0395	ABC-type sugar transport system, permease component
F3L20_RS20495	COG1175	transmembrane transport
F3L20_RS20515	COG1609	Transcriptional regulator
F3L20_RS20520	COG1879	ABC-type sugar transport system periplasmic component
F3L20_RS20525	COG1129	ABC transporter
F3L20_RS20530	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3L20_RS20535	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3L20_RS20560	COG2274	protein secretion by the type I secretion system
F3L20_RS20590	COG0640	Transcriptional regulator
F3L20_RS20620	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
F3L20_RS20645	COG2259	Doxx family
F3L20_RS20655	COG1733	regulation of RNA biosynthetic process
F3L20_RS20660	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F3L20_RS20665	COG2197	response regulator
F3L20_RS20680	COG1136	(ABC) transporter
F3L20_RS20680	COG0577	efflux transmembrane transporter activity
F3L20_RS20690	COG3021	interspecies interaction between organisms
F3L20_RS20705	COG1819	glycosyl
F3L20_RS20715	COG1595	DNA-templated transcription, initiation
F3L20_RS20725	COG1053	succinate dehydrogenase
F3L20_RS20760	COG1595	DNA-templated transcription, initiation
F3L20_RS20765	COG1263	PTS System
F3L20_RS20765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F3L20_RS20770	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F3L20_RS20780	COG0494	nUDIX hydrolase
F3L20_RS20825	COG2124	cytochrome p450
F3L20_RS20835	COG1024	Enoyl-CoA hydratase
F3L20_RS20840	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS20850	COG1357	PFAM Pentapeptide repeats (8 copies)
F3L20_RS20895	COG3766	membrane
F3L20_RS20925	COG1597	lipid kinase activity
F3L20_RS20930	COG0277	FAD linked oxidase domain protein
F3L20_RS20950	COG1082	Xylose isomerase domain protein TIM barrel
F3L20_RS20995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F3L20_RS21000	COG0395	ABC-type sugar transport system, permease component
F3L20_RS21005	COG1175	transmembrane transport
F3L20_RS21025	COG0596	Alpha beta hydrolase
F3L20_RS21065	COG2208	phosphoserine phosphatase activity
F3L20_RS21075	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
F3L20_RS21105	COG0358	DNA primase activity
F3L20_RS21110	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS21195	COG2226	methyltransferase
F3L20_RS21210	COG1063	alcohol dehydrogenase
F3L20_RS21215	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F3L20_RS21240	COG3540	Alkaline phosphatase
F3L20_RS21275	COG2124	cytochrome p450
F3L20_RS21290	COG0753	catalase activity
F3L20_RS21300	COG0009	L-threonylcarbamoyladenylate synthase
F3L20_RS21320	COG0656	L-ascorbic acid biosynthetic process
F3L20_RS21325	COG3285	dna ligase
F3L20_RS21325	COG1793	dna ligase
F3L20_RS21350	COG3285	dna ligase
F3L20_RS21350	COG1793	dna ligase
F3L20_RS21360	COG0181	hydroxymethylbilane synthase activity
F3L20_RS21420	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F3L20_RS21425	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F3L20_RS21450	COG2205	protein histidine kinase activity
F3L20_RS21450	COG5002	protein histidine kinase activity
F3L20_RS21450	COG0784	Response regulator, receiver
F3L20_RS21465	COG1366	Belongs to the anti-sigma-factor antagonist family
F3L20_RS21470	COG1366	Belongs to the anti-sigma-factor antagonist family
F3L20_RS21475	COG2172	sigma factor antagonist activity
F3L20_RS21490	COG1252	NADH dehydrogenase
F3L20_RS21535	COG0477	Major facilitator Superfamily
F3L20_RS21545	COG0583	DNA-binding transcription factor activity
F3L20_RS21595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F3L20_RS21625	COG2340	Cysteine-rich secretory protein family
F3L20_RS21635	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F3L20_RS21640	COG0515	serine threonine protein kinase
F3L20_RS21640	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F3L20_RS21650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3L20_RS21670	COG0667	Aldo Keto reductase
F3L20_RS21675	COG0328	RNA-DNA hybrid ribonuclease activity
F3L20_RS21695	COG0740	serine-type endopeptidase activity
F3L20_RS21700	COG0740	serine-type endopeptidase activity
F3L20_RS21705	COG1396	sequence-specific DNA binding
F3L20_RS21710	COG1191	sigma factor activity
F3L20_RS21745	COG0667	Aldo Keto reductase
F3L20_RS21750	COG0583	DNA-binding transcription factor activity
F3L20_RS21760	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F3L20_RS21765	COG0346	lactoylglutathione lyase activity
F3L20_RS21870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F3L20_RS21895	COG0494	nUDIX hydrolase
F3L20_RS21935	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
F3L20_RS21945	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F3L20_RS21960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F3L20_RS21965	COG1937	Protein conserved in bacteria
F3L20_RS21985	COG0745	RESPONSE REGULATOR receiver
F3L20_RS21995	COG2376	Dihydroxyacetone kinase
F3L20_RS22000	COG1461	Dihydroxyacetone kinase
F3L20_RS22030	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS22040	COG1902	pentaerythritol trinitrate reductase activity
F3L20_RS22040	COG0446	pyridine nucleotide-disulphide oxidoreductase
F3L20_RS22060	COG2890	protein-(glutamine-N5) methyltransferase activity
F3L20_RS22070	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F3L20_RS22080	COG3458	cephalosporin-C deacetylase activity
F3L20_RS22095	COG2226	methyltransferase
F3L20_RS22110	COG2186	Transcriptional regulator
F3L20_RS22215	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS22230	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS22240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F3L20_RS22265	COG0028	Belongs to the TPP enzyme family
F3L20_RS22285	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS22310	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F3L20_RS22315	COG1215	transferase activity, transferring glycosyl groups
F3L20_RS22350	COG1349	DNA-binding transcription factor activity
F3L20_RS22385	COG3467	pyridoxamine 5'-phosphate
F3L20_RS22395	COG1940	carbohydrate kinase activity
F3L20_RS22400	COG2813	Specifically methylates the guanine in position
F3L20_RS22405	COG3387	PFAM Glycoside hydrolase 15-related
F3L20_RS22425	COG4565	transcriptional regulatory protein
F3L20_RS22460	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS22475	COG2197	response regulator
F3L20_RS22480	COG4585	Histidine kinase
F3L20_RS22540	COG3655	Transcriptional regulator
F3L20_RS22555	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F3L20_RS22610	COG0584	glycerophosphoryl diester phosphodiesterase
F3L20_RS22645	COG0671	phosphoesterase, PA-phosphatase related
F3L20_RS22650	COG1309	transcriptional regulator
F3L20_RS22680	COG0640	Transcriptional regulator
F3L20_RS22685	COG1902	pentaerythritol trinitrate reductase activity
F3L20_RS22690	COG5297	Belongs to the glycosyl hydrolase family 6
F3L20_RS22700	COG1960	acyl-CoA dehydrogenase activity
F3L20_RS22710	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F3L20_RS22735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F3L20_RS22795	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F3L20_RS22800	COG1132	(ABC) transporter
F3L20_RS22815	COG1132	(ABC) transporter
F3L20_RS22825	COG0254	rRNA binding
F3L20_RS22840	COG1946	Acyl-CoA thioesterase
F3L20_RS22850	COG2018	Roadblock/LC7 domain
F3L20_RS22930	COG1960	acyl-CoA dehydrogenase activity
F3L20_RS22935	COG1960	acyl-CoA dehydrogenase activity
F3L20_RS22945	COG1476	TRANSCRIPTIONal
F3L20_RS22955	COG1793	dna ligase
F3L20_RS22965	COG1012	belongs to the aldehyde dehydrogenase family
F3L20_RS22975	COG1960	acyl-CoA dehydrogenase activity
F3L20_RS22985	COG0242	peptide deformylase activity
F3L20_RS22990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F3L20_RS22995	COG3442	glutamine amidotransferase
F3L20_RS23000	COG0205	6-phosphofructokinase activity
F3L20_RS23015	COG3275	phosphorelay sensor kinase activity
F3L20_RS23020	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F3L20_RS23030	COG3279	Response regulator of the LytR AlgR family
F3L20_RS23035	COG1522	sequence-specific DNA binding
F3L20_RS23040	COG1834	amidinotransferase
F3L20_RS23045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F3L20_RS23055	COG0395	ABC-type sugar transport system, permease component
F3L20_RS23060	COG1063	alcohol dehydrogenase
F3L20_RS23100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F3L20_RS23110	COG2171	N-acyltransferase activity
F3L20_RS23115	COG3226	Transcriptional regulator
F3L20_RS23125	COG2151	metal-sulfur cluster biosynthetic enzyme
F3L20_RS23130	COG0822	iron-sulfur transferase activity
F3L20_RS23135	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F3L20_RS23140	COG0396	ATPase activity
F3L20_RS23150	COG0719	Fe-S assembly protein
F3L20_RS23165	COG1131	(ABC) transporter
F3L20_RS23175	COG1612	heme a metabolic process
F3L20_RS23195	COG0109	protoheme IX farnesyltransferase activity
F3L20_RS23210	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F3L20_RS23225	COG0363	glucosamine-6-phosphate deaminase activity
F3L20_RS23230	COG0395	ABC-type sugar transport system, permease component
F3L20_RS23235	COG1175	transmembrane transport
F3L20_RS23245	COG0366	Alpha amylase catalytic
F3L20_RS23260	COG1136	(ABC) transporter
F3L20_RS23280	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F3L20_RS23285	COG0149	triose-phosphate isomerase activity
F3L20_RS23290	COG0126	phosphoglycerate kinase activity
F3L20_RS23295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F3L20_RS23305	COG1481	regulation of sporulation
F3L20_RS23310	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F3L20_RS23315	COG1660	Displays ATPase and GTPase activities
F3L20_RS23320	COG0322	excinuclease ABC activity
F3L20_RS23335	COG1609	Transcriptional regulator
F3L20_RS23345	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F3L20_RS23355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F3L20_RS23360	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F3L20_RS23365	COG0387	Pfam Sodium calcium exchanger
F3L20_RS23385	COG0556	nucleotide-excision repair
F3L20_RS23395	COG0584	glycerophosphoryl diester phosphodiesterase
F3L20_RS23400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F3L20_RS23410	COG2313	pseudouridylate synthase activity
F3L20_RS23420	COG0598	Magnesium transport protein CorA
F3L20_RS23480	COG0402	S-adenosylhomocysteine deaminase activity
F3L20_RS23500	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F3L20_RS23515	COG2267	carboxylic ester hydrolase activity
F3L20_RS23525	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F3L20_RS23530	COG2226	methyltransferase
F3L20_RS23545	COG0237	dephospho-CoA kinase activity
F3L20_RS23555	COG0539	negative regulation of cytoplasmic translation
F3L20_RS23565	COG1643	Atp-dependent helicase
F3L20_RS23595	COG2050	protein possibly involved in aromatic compounds catabolism
F3L20_RS23655	COG0737	Belongs to the 5'-nucleotidase family
F3L20_RS23665	COG0745	RESPONSE REGULATOR receiver
F3L20_RS23670	COG0287	Prephenate dehydrogenase
F3L20_RS23670	COG1605	Chorismate mutase
F3L20_RS23695	COG0067	glutamate synthase
F3L20_RS23695	COG0069	glutamate synthase activity
F3L20_RS23695	COG0070	glutamate synthase
F3L20_RS23705	COG1397	ADP-ribosylglycohydrolase
F3L20_RS23725	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F3L20_RS23730	COG2301	Belongs to the HpcH HpaI aldolase family
F3L20_RS23735	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F3L20_RS23745	COG0159	tryptophan synthase activity
F3L20_RS23750	COG0133	tryptophan synthase activity
F3L20_RS23760	COG0134	indole-3-glycerol-phosphate synthase activity
F3L20_RS23785	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F3L20_RS23795	COG0346	lactoylglutathione lyase activity
F3L20_RS23800	COG0107	imidazoleglycerol-phosphate synthase activity
F3L20_RS23805	COG0251	oxidation-reduction process
F3L20_RS23810	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F3L20_RS23815	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F3L20_RS23820	COG0131	Imidazoleglycerol-phosphate dehydratase
F3L20_RS23825	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F3L20_RS23830	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F3L20_RS23875	COG1432	Conserved Protein
F3L20_RS23880	COG0587	DNA-directed DNA polymerase activity
F3L20_RS23935	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F3L20_RS23945	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F3L20_RS23950	COG3599	regulation of cell shape
F3L20_RS23960	COG1799	cell septum assembly
F3L20_RS23970	COG1496	oxidoreductase activity
F3L20_RS23975	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F3L20_RS23980	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F3L20_RS23985	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F3L20_RS23995	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F3L20_RS24000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F3L20_RS24010	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F3L20_RS24025	COG0275	rRNA processing
F3L20_RS24035	COG0714	Associated with various cellular activities
F3L20_RS24055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F3L20_RS24065	COG1129	ABC transporter
F3L20_RS24075	COG1309	transcriptional regulator
F3L20_RS24110	COG2022	thiamine diphosphate biosynthetic process
F3L20_RS24110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3L20_RS24120	COG2022	thiamine diphosphate biosynthetic process
F3L20_RS24125	COG2815	serine threonine protein kinase
F3L20_RS24125	COG0515	serine threonine protein kinase
F3L20_RS24130	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
F3L20_RS24135	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F3L20_RS24140	COG2193	ferroxidase activity
F3L20_RS24150	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
F3L20_RS24170	COG0205	6-phosphofructokinase activity
F3L20_RS24180	COG4585	Histidine kinase
F3L20_RS24205	COG1940	carbohydrate kinase activity
F3L20_RS24215	COG0003	Pfam Anion-transporting ATPase
F3L20_RS24255	COG1388	LysM domain
F3L20_RS24255	COG3103	Sh3 type 3 domain protein
F3L20_RS24255	COG0791	NLP P60 protein
F3L20_RS24280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F3L20_RS24285	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F3L20_RS24290	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F3L20_RS24295	COG0723	plastoquinol--plastocyanin reductase activity
F3L20_RS24300	COG2010	Cytochrome c
F3L20_RS24305	COG1845	cytochrome c oxidase, subunit III
F3L20_RS24315	COG1376	ErfK ybiS ycfS ynhG family protein
F3L20_RS24325	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F3L20_RS24330	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F3L20_RS24340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F3L20_RS24365	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F3L20_RS24370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F3L20_RS24375	COG2197	response regulator
F3L20_RS24380	COG4585	Histidine kinase
F3L20_RS24420	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F3L20_RS24430	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
F3L20_RS24445	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F3L20_RS24450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F3L20_RS24465	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F3L20_RS24510	COG0321	lipoyl(octanoyl) transferase activity
F3L20_RS24515	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F3L20_RS24535	COG0174	glutamine synthetase
F3L20_RS24540	COG4974	Belongs to the 'phage' integrase family
F3L20_RS24590	COG1196	nuclear chromosome segregation
F3L20_RS24590	COG0741	lytic transglycosylase activity
F3L20_RS24590	COG0739	heme binding
F3L20_RS24680	COG0745	RESPONSE REGULATOR receiver
F3L20_RS24695	COG2197	response regulator
F3L20_RS24715	COG1309	transcriptional regulator
F3L20_RS24740	COG0366	Alpha amylase catalytic
F3L20_RS24745	COG3833	ABC-type maltose transport systems, permease component
F3L20_RS24750	COG1175	transmembrane transport
F3L20_RS24755	COG2182	Extracellular solute-binding protein
F3L20_RS24760	COG1609	Transcriptional regulator
F3L20_RS24770	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F3L20_RS24805	COG2318	DinB family
F3L20_RS24810	COG0174	glutamine synthetase
F3L20_RS24815	COG1017	nitric oxide dioxygenase activity
F3L20_RS24815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F3L20_RS24820	COG1959	2 iron, 2 sulfur cluster binding
F3L20_RS24835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F3L20_RS24835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F3L20_RS24875	COG1994	Peptidase M50
F3L20_RS24940	COG0584	glycerophosphoryl diester phosphodiesterase
F3L20_RS24960	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F3L20_RS24965	COG2814	Major facilitator Superfamily
F3L20_RS24975	COG3540	Alkaline phosphatase
F3L20_RS24980	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS24985	COG0667	Aldo Keto reductase
F3L20_RS25050	COG3022	response to hydroperoxide
F3L20_RS25055	COG0800	Aldolase
F3L20_RS25070	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F3L20_RS25080	COG2030	dehydratase
F3L20_RS25085	COG4585	Histidine kinase
F3L20_RS25090	COG2197	response regulator
F3L20_RS25100	COG0477	Major facilitator Superfamily
F3L20_RS25110	COG2247	cell wall binding repeat
F3L20_RS25110	COG0860	N-Acetylmuramoyl-L-alanine amidase
F3L20_RS25135	COG0438	transferase activity, transferring glycosyl groups
F3L20_RS25140	COG1309	transcriptional regulator
F3L20_RS25145	COG1657	PFAM Prenyltransferase squalene oxidase
F3L20_RS25160	COG3845	ABC transporter
F3L20_RS25210	COG4122	O-methyltransferase activity
F3L20_RS25315	COG0586	Pfam SNARE associated Golgi protein
F3L20_RS25325	COG1358	cellular component organization or biogenesis
F3L20_RS25375	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F3L20_RS25385	COG0477	Major facilitator Superfamily
F3L20_RS25390	COG1309	transcriptional regulator
F3L20_RS25405	COG0667	Aldo Keto reductase
F3L20_RS25410	COG0789	Transcriptional regulator
F3L20_RS25465	COG1741	Belongs to the pirin family
F3L20_RS25480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F3L20_RS25485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F3L20_RS25490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F3L20_RS25515	COG1280	lysine exporter protein (LysE YggA)
F3L20_RS25525	COG0477	Major facilitator Superfamily
F3L20_RS25535	COG2130	NADP-dependent
F3L20_RS25565	COG4213	ABC transporter substrate-binding protein
F3L20_RS25575	COG4214	carbohydrate transport
F3L20_RS25585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F3L20_RS25620	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F3L20_RS25710	COG3386	PFAM SMP-30 Gluconolaconase
F3L20_RS25715	COG1414	Transcriptional regulator
F3L20_RS25740	COG1077	Cell shape determining protein MreB Mrl
F3L20_RS25770	COG1070	Carbohydrate kinase
F3L20_RS25785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F3L20_RS25790	COG0358	DNA primase activity
F3L20_RS25800	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F3L20_RS25810	COG2949	membrane
F3L20_RS25815	COG0243	molybdopterin cofactor binding
F3L20_RS25845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F3L20_RS25850	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F3L20_RS25850	COG2146	nitrite reductase [NAD(P)H] activity
F3L20_RS25880	COG0574	Belongs to the PEP-utilizing enzyme family
F3L20_RS25880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F3L20_RS25915	COG0667	Aldo Keto reductase
F3L20_RS25920	COG0423	glycine-tRNA ligase activity
F3L20_RS25925	COG3443	Belongs to the bacterial solute-binding protein 9 family
F3L20_RS25925	COG0803	Belongs to the bacterial solute-binding protein 9 family
F3L20_RS25930	COG1121	(ABC) transporter
F3L20_RS25935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F3L20_RS25945	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F3L20_RS25950	COG1381	Involved in DNA repair and RecF pathway recombination
F3L20_RS25965	COG3293	Transposase
F3L20_RS26005	COG4585	Histidine kinase
F3L20_RS26010	COG2409	Drug exporters of the RND superfamily
F3L20_RS26055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F3L20_RS26075	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F3L20_RS26085	COG2315	Protein conserved in bacteria
F3L20_RS26095	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F3L20_RS26105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F3L20_RS26110	COG4948	Mandelate Racemase Muconate Lactonizing
F3L20_RS26120	COG1234	tRNA 3'-trailer cleavage
F3L20_RS26125	COG0537	adenosine 5'-monophosphoramidase activity
F3L20_RS26130	COG4946	Tricorn protease homolog
F3L20_RS26130	COG0793	Belongs to the peptidase S41A family
F3L20_RS26150	COG0484	heat shock protein binding
F3L20_RS26155	COG1420	regulation of RNA biosynthetic process
F3L20_RS26190	COG0481	GTPase activity
F3L20_RS26200	COG0268	Binds directly to 16S ribosomal RNA
F3L20_RS26220	COG1234	tRNA 3'-trailer cleavage
F3L20_RS26225	COG1596	polysaccharide export
F3L20_RS26225	COG1555	photosystem II stabilization
F3L20_RS26230	COG1307	EDD domain protein, DegV family
F3L20_RS26240	COG0495	leucyl-tRNA aminoacylation
F3L20_RS26255	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F3L20_RS26280	COG0588	phosphoglycerate mutase activity
F3L20_RS26285	COG0799	negative regulation of ribosome biogenesis
F3L20_RS26295	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F3L20_RS26300	COG0501	Belongs to the peptidase M48B family
F3L20_RS26315	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F3L20_RS26325	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F3L20_RS26335	COG0438	transferase activity, transferring glycosyl groups
F3L20_RS26350	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F3L20_RS26350	COG2755	lipolytic protein G-D-S-L family
F3L20_RS26355	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F3L20_RS26360	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F3L20_RS26365	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F3L20_RS26375	COG1530	ribonuclease E activity
F3L20_RS26405	COG0772	Belongs to the SEDS family
F3L20_RS26410	COG0768	penicillin binding
F3L20_RS26425	COG1077	Cell shape determining protein MreB Mrl
F3L20_RS26430	COG0105	UTP biosynthetic process
F3L20_RS26440	COG0285	dihydrofolate synthase activity
F3L20_RS26450	COG0525	valine-tRNA ligase activity
F3L20_RS26465	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F3L20_RS26470	COG0740	serine-type endopeptidase activity
F3L20_RS26475	COG0740	serine-type endopeptidase activity
F3L20_RS26480	COG0544	peptidyl-prolyl cis-trans isomerase activity
F3L20_RS26500	COG3594	Acyltransferase
F3L20_RS26515	COG4552	Acetyltransferase involved in intracellular survival and related
F3L20_RS26530	COG1113	amino acid transport
F3L20_RS26535	COG1268	BioY protein
F3L20_RS26545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F3L20_RS26555	COG1116	anion transmembrane transporter activity
F3L20_RS26570	COG1113	amino acid transport
F3L20_RS26580	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F3L20_RS26640	COG1309	transcriptional regulator
F3L20_RS26655	COG1846	Transcriptional regulator
F3L20_RS26670	COG2197	response regulator
F3L20_RS26690	COG3291	Pkd domain containing protein
F3L20_RS26690	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F3L20_RS26700	COG0668	transmembrane transport
F3L20_RS26715	COG1175	transmembrane transport
F3L20_RS26720	COG0395	ABC-type sugar transport system, permease component
F3L20_RS26725	COG1486	melibiose metabolic process
F3L20_RS26740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3L20_RS26770	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F3L20_RS26790	COG0577	efflux transmembrane transporter activity
F3L20_RS26790	COG1136	(ABC) transporter
F3L20_RS26825	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F3L20_RS26850	COG2267	carboxylic ester hydrolase activity
F3L20_RS26900	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F3L20_RS26920	COG0438	transferase activity, transferring glycosyl groups
F3L20_RS26940	COG0492	ferredoxin-NADP+ reductase activity
F3L20_RS26955	COG1131	(ABC) transporter
F3L20_RS27005	COG0596	Alpha beta hydrolase
F3L20_RS27040	COG1609	Transcriptional regulator
F3L20_RS27045	COG1129	ABC transporter
F3L20_RS27050	COG1879	ABC-type sugar transport system periplasmic component
F3L20_RS27055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F3L20_RS27060	COG1869	D-ribose catabolic process
F3L20_RS27075	COG0673	inositol 2-dehydrogenase activity
F3L20_RS27080	COG1609	Transcriptional regulator
F3L20_RS27110	COG0697	spore germination
F3L20_RS27120	COG1472	Belongs to the glycosyl hydrolase 3 family
F3L20_RS27145	COG2356	endonuclease I
F3L20_RS27160	COG0028	Belongs to the TPP enzyme family
F3L20_RS27170	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F3L20_RS27200	COG1946	Acyl-CoA thioesterase
F3L20_RS27210	COG1309	transcriptional regulator
F3L20_RS27215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F3L20_RS27230	COG1960	acyl-CoA dehydrogenase activity
F3L20_RS27255	COG3486	L-lysine 6-monooxygenase (NADPH) activity
F3L20_RS27265	COG4264	IucA IucC family
F3L20_RS27280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F3L20_RS27285	COG0589	response to stress
F3L20_RS27295	COG4977	sequence-specific DNA binding
F3L20_RS27300	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
F3L20_RS27325	COG0395	ABC-type sugar transport system, permease component
F3L20_RS27335	COG3979	chitinase
F3L20_RS27345	COG0745	RESPONSE REGULATOR receiver
F3L20_RS27380	COG0406	alpha-ribazole phosphatase activity
F3L20_RS27405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3L20_RS27445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F3L20_RS27450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3L20_RS27455	COG0765	amino acid transport
F3L20_RS27460	COG0765	amino acid transport
F3L20_RS27465	COG1126	abc transporter atp-binding protein
F3L20_RS27480	COG3397	chitin binding
F3L20_RS27540	COG0673	inositol 2-dehydrogenase activity
F3L20_RS27545	COG4702	Belongs to the UPF0303 family
F3L20_RS27560	COG0179	Fumarylacetoacetate (FAA) hydrolase
F3L20_RS27590	COG2267	carboxylic ester hydrolase activity
F3L20_RS27600	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F3L20_RS27665	COG3226	Transcriptional regulator
F3L20_RS27670	COG0110	maltose O-acetyltransferase activity
F3L20_RS27690	COG2814	Major facilitator Superfamily
F3L20_RS27695	COG2733	membrane
F3L20_RS27715	COG4555	ABC transporter
F3L20_RS27730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F3L20_RS27770	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F3L20_RS27780	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F3L20_RS27785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F3L20_RS27790	COG1263	PTS System
F3L20_RS27795	COG1263	PTS System
F3L20_RS27800	COG1234	tRNA 3'-trailer cleavage
F3L20_RS27825	COG1113	amino acid transport
F3L20_RS27835	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F3L20_RS27845	COG1335	isochorismatase
F3L20_RS27875	COG0277	FAD linked oxidase domain protein
F3L20_RS27885	COG3185	4-Hydroxyphenylpyruvate dioxygenase
F3L20_RS27895	COG1174	glycine betaine transport
F3L20_RS27900	COG0517	IMP dehydrogenase activity
F3L20_RS27900	COG1125	glycine betaine transport
F3L20_RS27905	COG1174	glycine betaine transport
F3L20_RS27925	COG1061	Type III restriction enzyme res subunit
F3L20_RS27930	COG3654	unkown
F3L20_RS27960	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F3L20_RS27975	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F3L20_RS27980	COG0395	ABC-type sugar transport system, permease component
F3L20_RS28000	COG1678	Uncharacterized ACR, COG1678
F3L20_RS28005	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F3L20_RS28010	COG0776	regulation of translation
F3L20_RS28020	COG3973	AAA domain
F3L20_RS28050	COG2223	nitrite transmembrane transporter activity
F3L20_RS28105	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F3L20_RS28110	COG0793	Belongs to the peptidase S41A family
F3L20_RS28120	COG2884	Cell division ATP-binding protein ftsE
F3L20_RS28135	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
F3L20_RS28140	COG0515	serine threonine protein kinase
F3L20_RS28145	COG0515	serine threonine protein kinase
F3L20_RS28160	COG1175	transmembrane transport
F3L20_RS28165	COG0395	ABC-type sugar transport system, permease component
F3L20_RS28170	COG1216	Glycosyl transferase, family 2
F3L20_RS28175	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F3L20_RS28180	COG1216	Glycosyl transferase, family 2
F3L20_RS28195	COG1764	response to oxidative stress
F3L20_RS28200	COG1846	Transcriptional regulator
F3L20_RS28220	COG1134	teichoic acid transport
F3L20_RS28225	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F3L20_RS28230	COG1215	transferase activity, transferring glycosyl groups
F3L20_RS28240	COG2902	Dehydrogenase
F3L20_RS28260	COG0653	protein targeting
F3L20_RS28270	COG3214	Protein conserved in bacteria
F3L20_RS28275	COG2197	response regulator
F3L20_RS28280	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F3L20_RS28295	COG0823	Involved in the tonB-independent uptake of proteins
F3L20_RS28300	COG5002	protein histidine kinase activity
F3L20_RS28300	COG5000	phosphorelay sensor kinase activity
F3L20_RS28305	COG0745	RESPONSE REGULATOR receiver
F3L20_RS28310	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
F3L20_RS28330	COG0714	Associated with various cellular activities
F3L20_RS28335	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
F3L20_RS28375	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
F3L20_RS28390	COG1482	cell wall glycoprotein biosynthetic process
F3L20_RS28400	COG2835	tetraacyldisaccharide 4'-kinase activity
F3L20_RS28405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F3L20_RS28410	COG1620	l-lactate permease
F3L20_RS28445	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F3L20_RS28450	COG0778	Nitroreductase
F3L20_RS28450	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
F3L20_RS28475	COG1316	TRANSCRIPTIONal
F3L20_RS28480	COG1316	TRANSCRIPTIONal
F3L20_RS28485	COG1316	TRANSCRIPTIONal
F3L20_RS28500	COG1316	TRANSCRIPTIONal
F3L20_RS28505	COG1607	acyl-coa hydrolase
F3L20_RS28510	COG1316	TRANSCRIPTIONal
F3L20_RS28520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F3L20_RS28535	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F3L20_RS28565	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F3L20_RS28580	COG2205	protein histidine kinase activity
F3L20_RS28585	COG0745	RESPONSE REGULATOR receiver
F3L20_RS28590	COG3104	oligopeptide transport
F3L20_RS28600	COG1366	Belongs to the anti-sigma-factor antagonist family
F3L20_RS28605	COG1191	sigma factor activity
F3L20_RS28610	COG1228	amidohydrolase
F3L20_RS28625	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
F3L20_RS28645	COG1316	TRANSCRIPTIONal
F3L20_RS28660	COG2755	lipolytic protein G-D-S-L family
F3L20_RS28665	COG0183	Belongs to the thiolase family
F3L20_RS28705	COG1136	(ABC) transporter
F3L20_RS28705	COG0577	efflux transmembrane transporter activity
F3L20_RS28710	COG0577	efflux transmembrane transporter activity
F3L20_RS28710	COG1136	(ABC) transporter
F3L20_RS28715	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F3L20_RS28720	COG1252	NADH dehydrogenase
F3L20_RS28740	COG0148	phosphopyruvate hydratase activity
F3L20_RS28765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F3L20_RS28810	COG0577	efflux transmembrane transporter activity
F3L20_RS28815	COG1136	(ABC) transporter
F3L20_RS28825	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F3L20_RS28870	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F3L20_RS28875	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F3L20_RS28880	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F3L20_RS28885	COG0193	aminoacyl-tRNA hydrolase activity
F3L20_RS28895	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F3L20_RS28905	COG1309	transcriptional regulator
F3L20_RS28915	COG4106	trans-aconitate 2-methyltransferase activity
F3L20_RS28925	COG2197	response regulator
F3L20_RS28940	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F3L20_RS28980	COG0488	(ABC) transporter
F3L20_RS28985	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F3L20_RS28990	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F3L20_RS29000	COG0084	hydrolase, TatD family'
F3L20_RS29035	COG0310	cobalt ion transport
F3L20_RS29045	COG1122	ATPase activity
F3L20_RS29050	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F3L20_RS29065	COG0442	prolyl-tRNA aminoacylation
F3L20_RS29070	COG2409	Drug exporters of the RND superfamily
F3L20_RS29080	COG4946	Tricorn protease homolog
F3L20_RS29080	COG0793	Belongs to the peptidase S41A family
F3L20_RS29095	COG2267	carboxylic ester hydrolase activity
F3L20_RS29100	COG2072	flavoprotein involved in K transport
F3L20_RS29110	COG0708	Exodeoxyribonuclease III
F3L20_RS29140	COG0315	cyclic pyranopterin monophosphate synthase activity
F3L20_RS29140	COG0521	Mo-molybdopterin cofactor biosynthetic process
F3L20_RS29145	COG0315	cyclic pyranopterin monophosphate synthase activity
F3L20_RS29160	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F3L20_RS29195	COG1970	mechanosensitive ion channel activity
F3L20_RS29220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F3L20_RS29220	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F3L20_RS29220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F3L20_RS29225	COG1105	Belongs to the carbohydrate kinase PfkB family
F3L20_RS29230	COG1349	DNA-binding transcription factor activity
F3L20_RS29235	COG0477	Major facilitator Superfamily
F3L20_RS29260	COG3384	dioxygenase
F3L20_RS29265	COG1846	Transcriptional regulator
F3L20_RS29300	COG2188	Transcriptional regulator
F3L20_RS29310	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F3L20_RS29370	COG0386	Belongs to the glutathione peroxidase family
F3L20_RS29395	COG1686	Belongs to the peptidase S11 family
F3L20_RS29425	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F3L20_RS29440	COG3903	Transcriptional regulator
F3L20_RS29440	COG3629	intracellular signal transduction
F3L20_RS29475	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F3L20_RS29475	COG0515	serine threonine protein kinase
F3L20_RS29485	COG1309	transcriptional regulator
F3L20_RS29495	COG0259	pyridoxamine-phosphate oxidase activity
F3L20_RS29505	COG2072	flavoprotein involved in K transport
F3L20_RS29510	COG2271	Major facilitator Superfamily
F3L20_RS29595	COG2945	thiolester hydrolase activity
F3L20_RS29595	COG0596	Alpha beta hydrolase
F3L20_RS29605	COG4821	SIS domain
F3L20_RS29625	COG0259	pyridoxamine-phosphate oxidase activity
F3L20_RS29640	COG0318	PFAM AMP-dependent synthetase and ligase
F3L20_RS29655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F3L20_RS29670	COG5006	permease, DMT superfamily
F3L20_RS29690	COG0247	lactate metabolic process
F3L20_RS29690	COG0277	FAD linked oxidase domain protein
F3L20_RS29730	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F3L20_RS29760	COG0667	Aldo Keto reductase
F3L20_RS29790	COG2252	PERMEase
F3L20_RS29800	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F3L20_RS29805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F3L20_RS29805	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F3L20_RS29820	COG0739	heme binding
F3L20_RS29850	COG2814	Major facilitator Superfamily
F3L20_RS29860	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F3L20_RS29865	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
F3L20_RS29870	COG1278	Cold shock
F3L20_RS29895	COG1061	Type III restriction enzyme res subunit
F3L20_RS29925	COG0667	Aldo Keto reductase
F3L20_RS29935	COG3973	AAA domain
F3L20_RS29955	COG4257	antibiotic catabolic process
F3L20_RS29980	COG1737	Transcriptional regulator
F3L20_RS29985	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F3L20_RS30005	COG0459	protein refolding
F3L20_RS30010	COG1278	Cold shock
F3L20_RS30025	COG0463	Glycosyl transferase, family 2
F3L20_RS30030	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
F3L20_RS30070	COG3300	MHYT domain
F3L20_RS30070	COG5001	Diguanylate cyclase
F3L20_RS30085	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F3L20_RS30140	COG2378	regulation of single-species biofilm formation
F3L20_RS30145	COG3842	ATPase activity
F3L20_RS30155	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F3L20_RS30165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F3L20_RS30170	COG0215	cysteine-tRNA ligase activity
F3L20_RS30175	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F3L20_RS30180	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F3L20_RS30190	COG1329	Transcriptional regulator
F3L20_RS30210	COG5002	protein histidine kinase activity
F3L20_RS30225	COG0588	phosphoglycerate mutase activity
F3L20_RS30250	COG4977	sequence-specific DNA binding
F3L20_RS30270	COG0438	transferase activity, transferring glycosyl groups
F3L20_RS30315	COG2318	DinB family
F3L20_RS30320	COG0395	ABC-type sugar transport system, permease component
F3L20_RS30325	COG1175	transmembrane transport
F3L20_RS30340	COG2186	Transcriptional regulator
F3L20_RS30350	COG2186	Transcriptional regulator
F3L20_RS30365	COG2188	Transcriptional regulator
F3L20_RS30385	COG4552	Acetyltransferase involved in intracellular survival and related
F3L20_RS30395	COG1490	D-aminoacyl-tRNA deacylase activity
F3L20_RS30400	COG0354	folic acid binding
F3L20_RS30405	COG0735	belongs to the Fur family
F3L20_RS30410	COG3485	protocatechuate 3,4-dioxygenase
F3L20_RS30435	COG2897	thiosulfate sulfurtransferase activity
F3L20_RS30460	COG0745	RESPONSE REGULATOR receiver
F3L20_RS30465	COG1609	Transcriptional regulator
F3L20_RS30470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F3L20_RS30475	COG0745	RESPONSE REGULATOR receiver
F3L20_RS30490	COG0737	Belongs to the 5'-nucleotidase family
F3L20_RS30495	COG0456	acetyltransferase
F3L20_RS30510	COG1131	(ABC) transporter
F3L20_RS30530	COG1131	(ABC) transporter
F3L20_RS30540	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F3L20_RS30555	COG0406	alpha-ribazole phosphatase activity
F3L20_RS30555	COG0494	nUDIX hydrolase
F3L20_RS30575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F3L20_RS30580	COG0306	phosphate transporter
F3L20_RS30590	COG1937	Protein conserved in bacteria
F3L20_RS30605	COG0277	FAD linked oxidase domain protein
F3L20_RS30610	COG0671	phosphoesterase, PA-phosphatase related
F3L20_RS30615	COG0739	heme binding
F3L20_RS30615	COG0741	lytic transglycosylase activity
F3L20_RS30615	COG1196	nuclear chromosome segregation
F3L20_RS30685	COG1846	Transcriptional regulator
F3L20_RS30700	COG1252	NADH dehydrogenase
F3L20_RS30720	COG0579	oxidoreductase
F3L20_RS30725	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F3L20_RS30745	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F3L20_RS30745	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F3L20_RS30750	COG2197	response regulator
F3L20_RS30770	COG0513	Belongs to the DEAD box helicase family
F3L20_RS30805	COG1643	Atp-dependent helicase
F3L20_RS30830	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F3L20_RS30840	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F3L20_RS30870	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F3L20_RS30875	COG0047	phosphoribosylformylglycinamidine synthase activity
F3L20_RS30880	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F3L20_RS30910	COG3851	Histidine kinase
F3L20_RS30915	COG2197	response regulator
F3L20_RS30925	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F3L20_RS30940	COG0151	Belongs to the GarS family
F3L20_RS30960	COG0210	DNA helicase
F3L20_RS30975	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS31015	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F3L20_RS31045	COG1191	sigma factor activity
F3L20_RS31050	COG1191	sigma factor activity
F3L20_RS31070	COG2353	YceI-like domain
F3L20_RS31085	COG3467	pyridoxamine 5'-phosphate
F3L20_RS31095	COG0477	Major facilitator Superfamily
F3L20_RS31100	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F3L20_RS31110	COG2205	protein histidine kinase activity
F3L20_RS31115	COG0745	RESPONSE REGULATOR receiver
F3L20_RS31135	COG1846	Transcriptional regulator
F3L20_RS31145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F3L20_RS31150	COG0277	FAD linked oxidase domain protein
F3L20_RS31175	COG0784	Response regulator, receiver
F3L20_RS31180	COG0318	PFAM AMP-dependent synthetase and ligase
F3L20_RS31185	COG1595	DNA-templated transcription, initiation
F3L20_RS31230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F3L20_RS31250	COG0653	protein targeting
F3L20_RS31270	COG0006	proline dipeptidase activity
F3L20_RS31290	COG1999	signal sequence binding
F3L20_RS31305	COG2837	iron assimilation
F3L20_RS31315	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F3L20_RS31320	COG0561	phosphatase activity
F3L20_RS31345	COG1131	(ABC) transporter
F3L20_RS31355	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
F3L20_RS31370	COG0561	phosphatase activity
F3L20_RS31380	COG4988	ABC transporter
F3L20_RS31385	COG1294	oxidase, subunit
F3L20_RS31390	COG1271	oxidase subunit
F3L20_RS31395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F3L20_RS31400	COG1609	Transcriptional regulator
F3L20_RS31420	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F3L20_RS31445	COG0662	Cupin 2, conserved barrel domain protein
F3L20_RS31450	COG1950	PFAM Membrane protein of
F3L20_RS31455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F3L20_RS31460	COG0626	cystathionine gamma-synthase activity
F3L20_RS31485	COG2814	Major facilitator Superfamily
F3L20_RS31510	COG0305	Participates in initiation and elongation during chromosome replication
F3L20_RS31520	COG0359	binds to the 23S rRNA
F3L20_RS31525	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F3L20_RS31530	COG0629	single-stranded DNA binding
F3L20_RS31535	COG0360	Binds together with S18 to 16S ribosomal RNA
F3L20_RS31560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F3L20_RS31570	COG1260	myo-inositol-1-phosphate synthase
F3L20_RS31585	COG0617	tRNA 3'-terminal CCA addition
F3L20_RS31605	COG1595	DNA-templated transcription, initiation
F3L20_RS31615	COG0492	ferredoxin-NADP+ reductase activity
F3L20_RS31620	COG3118	belongs to the thioredoxin family
F3L20_RS31635	COG1192	Involved in chromosome partitioning
F3L20_RS31640	COG0357	Ribosomal RNA small subunit methyltransferase G
F3L20_RS31650	COG0706	membrane insertase activity
F3L20_RS31655	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F3L20_RS31660	COG0594	ribonuclease P activity
F3L20_RS31665	COG0230	Belongs to the bacterial ribosomal protein bL34 family
F3L20_RS31760	COG1309	transcriptional regulator
F3L20_RS31785	COG0655	NAD(P)H dehydrogenase (quinone) activity
F3L20_RS31795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3L20_RS31810	COG1309	transcriptional regulator
F3L20_RS31815	COG1024	Enoyl-CoA hydratase
F3L20_RS31855	COG0477	Major facilitator Superfamily
F3L20_RS31860	COG1309	transcriptional regulator
F3L20_RS31875	COG1192	Involved in chromosome partitioning
F3L20_RS31925	COG0655	NAD(P)H dehydrogenase (quinone) activity
F3L20_RS31955	COG0583	DNA-binding transcription factor activity
F3L20_RS31980	COG0596	Alpha beta hydrolase
F3L20_RS31985	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS31990	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F3L20_RS32005	COG1252	NADH dehydrogenase
F3L20_RS32045	COG2814	Major facilitator Superfamily
F3L20_RS32070	COG1846	Transcriptional regulator
F3L20_RS32080	COG0300	oxidoreductase activity
F3L20_RS32085	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS32100	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS32135	COG1404	Belongs to the peptidase S8 family
F3L20_RS32150	COG1764	response to oxidative stress
F3L20_RS32190	COG0477	Major facilitator Superfamily
F3L20_RS32230	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS32245	COG0596	Alpha beta hydrolase
F3L20_RS32410	COG0667	Aldo Keto reductase
F3L20_RS32420	COG1609	Transcriptional regulator
F3L20_RS32425	COG1940	carbohydrate kinase activity
F3L20_RS32440	COG1175	transmembrane transport
F3L20_RS32445	COG0395	ABC-type sugar transport system, permease component
F3L20_RS32560	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F3L20_RS32575	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS32620	COG3469	chitinase activity
F3L20_RS32660	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F3L20_RS32660	COG1017	nitric oxide dioxygenase activity
F3L20_RS32670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F3L20_RS32695	COG2197	response regulator
F3L20_RS32755	COG2175	clavaminate synthase activity
F3L20_RS32785	COG3186	Phenylalanine-4-hydroxylase
F3L20_RS32795	COG3903	Transcriptional regulator
F3L20_RS32795	COG3629	intracellular signal transduction
F3L20_RS32955	COG0372	Belongs to the citrate synthase family
F3L20_RS32960	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F3L20_RS32980	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS32985	COG0110	maltose O-acetyltransferase activity
F3L20_RS33030	COG4977	sequence-specific DNA binding
F3L20_RS33035	COG2249	NAD(P)H dehydrogenase (quinone) activity
F3L20_RS33120	COG1131	(ABC) transporter
F3L20_RS33125	COG1725	Transcriptional regulator
F3L20_RS33140	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F3L20_RS33160	COG1902	pentaerythritol trinitrate reductase activity
F3L20_RS33165	COG0596	Alpha beta hydrolase
F3L20_RS33165	COG0508	dehydrogenase complex catalyzes the overall conversion of
F3L20_RS33210	COG0789	Transcriptional regulator
F3L20_RS33220	COG1902	pentaerythritol trinitrate reductase activity
F3L20_RS33250	COG1902	pentaerythritol trinitrate reductase activity
F3L20_RS33300	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F3L20_RS33300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F3L20_RS33315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F3L20_RS33340	COG0745	RESPONSE REGULATOR receiver
F3L20_RS33345	COG5002	protein histidine kinase activity
F3L20_RS33365	COG0519	Catalyzes the synthesis of GMP from XMP
F3L20_RS33365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F3L20_RS33370	COG2186	Transcriptional regulator
F3L20_RS33375	COG0110	maltose O-acetyltransferase activity
F3L20_RS33450	COG3547	Transposase (IS116 IS110 IS902 family)
F3L20_RS33525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F3L20_RS33560	COG1028	Short-chain dehydrogenase reductase Sdr
F3L20_RS33700	COG0242	peptide deformylase activity