locus-tag	class	description
JVE63_RS00025	COG2197	response regulator
JVE63_RS00035	COG1028	Short-chain dehydrogenase reductase Sdr
JVE63_RS00055	COG0726	polysaccharide deacetylase
JVE63_RS00100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JVE63_RS00110	COG1349	DNA-binding transcription factor activity
JVE63_RS00120	COG3397	chitin binding
JVE63_RS00130	COG0531	amino acid
JVE63_RS00135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JVE63_RS00150	COG1174	glycine betaine transport
JVE63_RS00155	COG1174	glycine betaine transport
JVE63_RS00170	COG0517	IMP dehydrogenase activity
JVE63_RS00170	COG1125	glycine betaine transport
JVE63_RS00190	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JVE63_RS00210	COG0601	transmembrane transport
JVE63_RS00215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JVE63_RS00220	COG0444	Belongs to the ABC transporter superfamily
JVE63_RS00225	COG1124	(ABC) transporter
JVE63_RS00240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JVE63_RS00275	COG2197	response regulator
JVE63_RS00305	COG1595	DNA-templated transcription, initiation
JVE63_RS00315	COG0318	PFAM AMP-dependent synthetase and ligase
JVE63_RS00320	COG2124	cytochrome p450
JVE63_RS00325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JVE63_RS00340	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
JVE63_RS00345	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JVE63_RS00360	COG1136	(ABC) transporter
JVE63_RS00365	COG1136	(ABC) transporter
JVE63_RS00365	COG0577	efflux transmembrane transporter activity
JVE63_RS00375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JVE63_RS00390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JVE63_RS00400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JVE63_RS00405	COG2205	protein histidine kinase activity
JVE63_RS00410	COG0745	RESPONSE REGULATOR receiver
JVE63_RS00415	COG0326	Molecular chaperone. Has ATPase activity
JVE63_RS00445	COG3424	synthase
JVE63_RS00450	COG1024	Enoyl-CoA hydratase
JVE63_RS00455	COG1024	Enoyl-CoA hydratase
JVE63_RS00510	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JVE63_RS00525	COG2018	Roadblock/LC7 domain
JVE63_RS00540	COG1063	alcohol dehydrogenase
JVE63_RS00545	COG0156	8-amino-7-oxononanoate synthase activity
JVE63_RS00585	COG0475	glutathione-regulated potassium exporter activity
JVE63_RS00585	COG0569	domain protein
JVE63_RS00605	COG4264	IucA IucC family
JVE63_RS00640	COG1966	Carbon starvation protein
JVE63_RS00665	COG2124	cytochrome p450
JVE63_RS00670	COG2124	cytochrome p450
JVE63_RS00690	COG1446	asparaginase
JVE63_RS00700	COG1309	transcriptional regulator
JVE63_RS00750	COG1309	transcriptional regulator
JVE63_RS00760	COG2226	methyltransferase
JVE63_RS00775	COG0789	Transcriptional regulator
JVE63_RS00845	COG2362	D-Aminopeptidase
JVE63_RS00850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JVE63_RS00860	COG1619	proteins homologs of microcin C7 resistance protein MccF
JVE63_RS00865	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JVE63_RS00890	COG0457	Tetratricopeptide repeat
JVE63_RS00920	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
JVE63_RS00955	COG1793	dna ligase
JVE63_RS00980	COG0656	L-ascorbic acid biosynthetic process
JVE63_RS00995	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JVE63_RS01000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JVE63_RS01015	COG1129	ABC transporter
JVE63_RS01020	COG1172	Belongs to the binding-protein-dependent transport system permease family
JVE63_RS01030	COG0673	inositol 2-dehydrogenase activity
JVE63_RS01125	COG1063	alcohol dehydrogenase
JVE63_RS01130	COG2124	cytochrome p450
JVE63_RS01185	COG1104	cysteine desulfurase activity
JVE63_RS01190	COG1028	Short-chain dehydrogenase reductase Sdr
JVE63_RS01210	COG1509	lysine 2,3-aminomutase activity
JVE63_RS01240	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
JVE63_RS01245	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
JVE63_RS01250	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
JVE63_RS01255	COG1132	(ABC) transporter
JVE63_RS01260	COG1132	(ABC) transporter
JVE63_RS01280	COG3012	SEC-C Motif Domain Protein
JVE63_RS01290	COG3757	hydrolase, family 25
JVE63_RS01290	COG3409	Peptidoglycan-binding domain 1 protein
JVE63_RS01340	COG1940	carbohydrate kinase activity
JVE63_RS01345	COG2115	Belongs to the xylose isomerase family
JVE63_RS01355	COG1793	dna ligase
JVE63_RS01395	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JVE63_RS01400	COG0488	(ABC) transporter
JVE63_RS01415	COG1515	deoxyribonuclease V activity
JVE63_RS01420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JVE63_RS01425	COG0183	Belongs to the thiolase family
JVE63_RS01430	COG1250	3-hydroxyacyl-CoA dehydrogenase
JVE63_RS01430	COG1024	Enoyl-CoA hydratase
JVE63_RS01450	COG3568	Endonuclease Exonuclease Phosphatase
JVE63_RS01455	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JVE63_RS01460	COG2936	dipeptidyl-peptidase activity
JVE63_RS01470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JVE63_RS01480	COG2183	response to ionizing radiation
JVE63_RS01485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JVE63_RS01490	COG4977	sequence-specific DNA binding
JVE63_RS01525	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
JVE63_RS01550	COG0371	Dehydrogenase
JVE63_RS01565	COG1562	ergosterol biosynthetic process
JVE63_RS01575	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
JVE63_RS01585	COG1657	PFAM Prenyltransferase squalene oxidase
JVE63_RS01615	COG2365	Tyrosine phosphatase family
JVE63_RS01620	COG0739	heme binding
JVE63_RS01625	COG2755	lipolytic protein G-D-S-L family
JVE63_RS01690	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JVE63_RS01825	COG0789	Transcriptional regulator
JVE63_RS01835	COG1522	sequence-specific DNA binding
JVE63_RS01845	COG1176	ABC-type spermidine putrescine transport system, permease component I
JVE63_RS01850	COG1177	transmembrane transport
JVE63_RS01855	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JVE63_RS01860	COG3842	ATPase activity
JVE63_RS01865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JVE63_RS01870	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JVE63_RS01905	COG1733	regulation of RNA biosynthetic process
JVE63_RS01915	COG3321	synthase
JVE63_RS01915	COG0604	alcohol dehydrogenase
JVE63_RS01930	COG0596	Alpha beta hydrolase
JVE63_RS02005	COG3119	arylsulfatase activity
JVE63_RS02015	COG1051	belongs to the nudix hydrolase family
JVE63_RS02030	COG2264	protein methyltransferase activity
JVE63_RS02035	COG0483	inositol monophosphate 1-phosphatase activity
JVE63_RS02075	COG2835	tetraacyldisaccharide 4'-kinase activity
JVE63_RS02095	COG4981	capsule polysaccharide biosynthetic process
JVE63_RS02100	COG0500	methyltransferase
JVE63_RS02130	COG1120	ATPase activity
JVE63_RS02135	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JVE63_RS02140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JVE63_RS02145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JVE63_RS02225	COG2124	cytochrome p450
JVE63_RS02230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JVE63_RS02270	COG3119	arylsulfatase activity
JVE63_RS02290	COG2226	methyltransferase
JVE63_RS02305	COG2226	methyltransferase
JVE63_RS02310	COG0747	negative chemotaxis
JVE63_RS02315	COG4608	Belongs to the ABC transporter superfamily
JVE63_RS02320	COG0444	Belongs to the ABC transporter superfamily
JVE63_RS02325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JVE63_RS02340	COG1012	belongs to the aldehyde dehydrogenase family
JVE63_RS02350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JVE63_RS02355	COG2301	Belongs to the HpcH HpaI aldolase family
JVE63_RS02365	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JVE63_RS02375	COG2079	MmgE PrpD family protein
JVE63_RS02380	COG1414	Transcriptional regulator
JVE63_RS02385	COG0542	response to heat
JVE63_RS02455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JVE63_RS02460	COG1454	alcohol dehydrogenase
JVE63_RS02465	COG0028	Belongs to the TPP enzyme family
JVE63_RS02465	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
JVE63_RS02485	COG0137	argininosuccinate synthase activity
JVE63_RS02520	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JVE63_RS02555	COG0789	Transcriptional regulator
JVE63_RS02600	COG2197	response regulator
JVE63_RS02635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JVE63_RS02650	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JVE63_RS02660	COG3864	Putative metallopeptidase domain
JVE63_RS02670	COG0456	acetyltransferase
JVE63_RS02680	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
JVE63_RS02685	COG2079	MmgE PrpD family protein
JVE63_RS02690	COG4977	sequence-specific DNA binding
JVE63_RS02705	COG0604	alcohol dehydrogenase
JVE63_RS02710	COG1476	TRANSCRIPTIONal
JVE63_RS02770	COG0318	PFAM AMP-dependent synthetase and ligase
JVE63_RS02825	COG1278	Cold shock
JVE63_RS02860	COG0464	growth
JVE63_RS02865	COG1404	Belongs to the peptidase S8 family
JVE63_RS02870	COG1674	ftsk spoiiie
JVE63_RS02955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JVE63_RS03005	COG0142	geranyltranstransferase activity
JVE63_RS03015	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
JVE63_RS03025	COG0009	L-threonylcarbamoyladenylate synthase
JVE63_RS03030	COG1012	belongs to the aldehyde dehydrogenase family
JVE63_RS03055	COG0183	Belongs to the thiolase family
JVE63_RS03065	COG1250	3-hydroxyacyl-CoA dehydrogenase
JVE63_RS03070	COG3396	Phenylacetate-CoA oxygenase
JVE63_RS03075	COG3460	Phenylacetate-CoA oxygenase
JVE63_RS03080	COG3396	Phenylacetate-CoA oxygenase
JVE63_RS03085	COG2151	metal-sulfur cluster biosynthetic enzyme
JVE63_RS03090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JVE63_RS03095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JVE63_RS03105	COG1396	sequence-specific DNA binding
JVE63_RS03110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JVE63_RS03115	COG2205	protein histidine kinase activity
JVE63_RS03120	COG0745	RESPONSE REGULATOR receiver
JVE63_RS03135	COG3485	protocatechuate 3,4-dioxygenase
JVE63_RS03160	COG0640	Transcriptional regulator
JVE63_RS03195	COG2197	response regulator
JVE63_RS03200	COG2267	carboxylic ester hydrolase activity
JVE63_RS03235	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
JVE63_RS03250	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
JVE63_RS03305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JVE63_RS03325	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JVE63_RS03330	COG3275	phosphorelay sensor kinase activity
JVE63_RS03390	COG0583	DNA-binding transcription factor activity
JVE63_RS03400	COG1053	succinate dehydrogenase
JVE63_RS03405	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JVE63_RS03415	COG3360	Dodecin
JVE63_RS03420	COG2182	Extracellular solute-binding protein
JVE63_RS03425	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
JVE63_RS03430	COG0121	glutamine amidotransferase
JVE63_RS03435	COG1262	PFAM Formylglycine-generating sulfatase enzyme
JVE63_RS03440	COG3572	ergothioneine biosynthetic process
JVE63_RS03450	COG1609	Transcriptional regulator
JVE63_RS03460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JVE63_RS03485	COG2197	response regulator
JVE63_RS03500	COG1335	isochorismatase
JVE63_RS03515	COG1028	Short-chain dehydrogenase reductase Sdr
JVE63_RS03520	COG1028	Short-chain dehydrogenase reductase Sdr
JVE63_RS03525	COG0402	S-adenosylhomocysteine deaminase activity
JVE63_RS03550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JVE63_RS03605	COG3629	intracellular signal transduction
JVE63_RS03605	COG3903	Transcriptional regulator
JVE63_RS03620	COG0604	alcohol dehydrogenase
JVE63_RS03620	COG3321	synthase
JVE63_RS03650	COG0596	Alpha beta hydrolase
JVE63_RS03670	COG3321	synthase
JVE63_RS03670	COG0604	alcohol dehydrogenase
JVE63_RS03680	COG3321	synthase
JVE63_RS03680	COG0604	alcohol dehydrogenase
JVE63_RS03685	COG1250	3-hydroxyacyl-CoA dehydrogenase
JVE63_RS03710	COG3903	Transcriptional regulator
JVE63_RS03710	COG3629	intracellular signal transduction
JVE63_RS03740	COG4585	Histidine kinase
JVE63_RS03745	COG2197	response regulator
JVE63_RS03755	COG1396	sequence-specific DNA binding
JVE63_RS03765	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
JVE63_RS03770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JVE63_RS03785	COG2814	Major facilitator Superfamily
JVE63_RS03810	COG1215	transferase activity, transferring glycosyl groups
JVE63_RS03820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JVE63_RS03825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JVE63_RS03835	COG1215	transferase activity, transferring glycosyl groups
JVE63_RS03850	COG0667	Aldo Keto reductase
JVE63_RS03865	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JVE63_RS03880	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
JVE63_RS03895	COG2957	Belongs to the agmatine deiminase family
JVE63_RS03910	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JVE63_RS03930	COG0006	proline dipeptidase activity
JVE63_RS03945	COG0745	RESPONSE REGULATOR receiver
JVE63_RS03950	COG2205	protein histidine kinase activity
JVE63_RS03975	COG0702	epimerase
JVE63_RS03990	COG2205	protein histidine kinase activity
JVE63_RS03995	COG0745	RESPONSE REGULATOR receiver
JVE63_RS04010	COG1376	ErfK ybiS ycfS ynhG family protein
JVE63_RS04045	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JVE63_RS04045	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JVE63_RS04050	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JVE63_RS04070	COG0596	Alpha beta hydrolase
JVE63_RS04090	COG1335	isochorismatase
JVE63_RS04105	COG0657	acetylesterase activity
JVE63_RS04125	COG0714	Associated with various cellular activities
JVE63_RS04140	COG2366	antibiotic biosynthetic process
JVE63_RS04190	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JVE63_RS04190	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JVE63_RS04200	COG2409	Drug exporters of the RND superfamily
JVE63_RS04210	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JVE63_RS04215	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
JVE63_RS04255	COG0438	transferase activity, transferring glycosyl groups
JVE63_RS04265	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
JVE63_RS04280	COG4310	Domain of unknown function (DUF2172)
JVE63_RS04290	COG1216	Glycosyl transferase, family 2
JVE63_RS04290	COG0463	Glycosyl transferase, family 2
JVE63_RS04305	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JVE63_RS04350	COG2755	lipolytic protein G-D-S-L family
JVE63_RS04360	COG0402	S-adenosylhomocysteine deaminase activity
JVE63_RS04375	COG2124	cytochrome p450
JVE63_RS04375	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JVE63_RS04395	COG1349	DNA-binding transcription factor activity
JVE63_RS04400	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JVE63_RS04405	COG0579	oxidoreductase
JVE63_RS04440	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JVE63_RS04440	COG1796	DNA polymerase
JVE63_RS04485	COG0501	Belongs to the peptidase M48B family
JVE63_RS04515	COG0494	nUDIX hydrolase
JVE63_RS04525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JVE63_RS04525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JVE63_RS04570	COG2226	methyltransferase
JVE63_RS04580	COG1024	Enoyl-CoA hydratase
JVE63_RS04585	COG1960	acyl-CoA dehydrogenase activity
JVE63_RS04595	COG2197	response regulator
JVE63_RS04600	COG4585	Histidine kinase
JVE63_RS04635	COG4941	Belongs to the sigma-70 factor family
JVE63_RS04640	COG3795	YCII-related domain
JVE63_RS04650	COG3845	ABC transporter
JVE63_RS04675	COG0515	serine threonine protein kinase
JVE63_RS04695	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JVE63_RS04700	COG1518	maintenance of DNA repeat elements
JVE63_RS04715	COG1857	crispr-associated protein
JVE63_RS04745	COG1028	Short-chain dehydrogenase reductase Sdr
JVE63_RS04750	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JVE63_RS04760	COG2070	2-Nitropropane dioxygenase
JVE63_RS04770	COG0387	Pfam Sodium calcium exchanger
JVE63_RS04775	COG0515	serine threonine protein kinase
JVE63_RS04785	COG1132	(ABC) transporter
JVE63_RS04790	COG1132	(ABC) transporter
JVE63_RS04795	COG2197	response regulator
JVE63_RS04805	COG1414	Transcriptional regulator
JVE63_RS04810	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JVE63_RS04815	COG0277	FAD linked oxidase domain protein
JVE63_RS04815	COG0247	lactate metabolic process
JVE63_RS04825	COG1024	Enoyl-CoA hydratase
JVE63_RS04910	COG1819	glycosyl
JVE63_RS04925	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JVE63_RS04930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JVE63_RS04995	COG0596	Alpha beta hydrolase
JVE63_RS05020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JVE63_RS05030	COG0488	(ABC) transporter
JVE63_RS05035	COG0259	pyridoxamine-phosphate oxidase activity
JVE63_RS05045	COG2304	oxidoreductase activity
JVE63_RS05050	COG0494	nUDIX hydrolase
JVE63_RS05080	COG2267	carboxylic ester hydrolase activity
JVE63_RS05140	COG1250	3-hydroxyacyl-CoA dehydrogenase
JVE63_RS05150	COG1960	acyl-CoA dehydrogenase activity
JVE63_RS05160	COG2197	response regulator
JVE63_RS05190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JVE63_RS05200	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
JVE63_RS05200	COG1672	PFAM Archaeal ATPase
JVE63_RS05205	COG0134	indole-3-glycerol-phosphate synthase activity
JVE63_RS05215	COG1960	acyl-CoA dehydrogenase activity
JVE63_RS05220	COG0662	Cupin 2, conserved barrel domain protein
JVE63_RS05240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JVE63_RS05275	COG0736	holo-[acyl-carrier-protein] synthase activity
JVE63_RS05280	COG4585	Histidine kinase
JVE63_RS05290	COG1131	(ABC) transporter
JVE63_RS05295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JVE63_RS05320	COG0436	Aminotransferase
JVE63_RS05325	COG1509	lysine 2,3-aminomutase activity
JVE63_RS05425	COG1834	amidinotransferase
JVE63_RS05455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JVE63_RS05460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JVE63_RS05460	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
JVE63_RS05465	COG0644	oxidoreductase
JVE63_RS05480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JVE63_RS05485	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
JVE63_RS05520	COG3321	synthase
JVE63_RS05520	COG0604	alcohol dehydrogenase
JVE63_RS05535	COG2124	cytochrome p450
JVE63_RS05570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JVE63_RS05625	COG0779	Required for maturation of 30S ribosomal subunits
JVE63_RS05650	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JVE63_RS05655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JVE63_RS05665	COG4608	Belongs to the ABC transporter superfamily
JVE63_RS05675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JVE63_RS05685	COG0747	negative chemotaxis
JVE63_RS05690	COG0455	bacterial-type flagellum organization
JVE63_RS05730	COG1404	Belongs to the peptidase S8 family
JVE63_RS05760	COG1674	ftsk spoiiie
JVE63_RS05770	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JVE63_RS05775	COG1185	polyribonucleotide nucleotidyltransferase activity
JVE63_RS05780	COG0612	Peptidase, M16
JVE63_RS05785	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JVE63_RS05805	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
JVE63_RS05810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JVE63_RS05815	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JVE63_RS05855	COG1674	ftsk spoiiie
JVE63_RS05875	COG1546	Belongs to the CinA family
JVE63_RS05875	COG1058	Belongs to the CinA family
JVE63_RS05880	COG1396	sequence-specific DNA binding
JVE63_RS05895	COG1028	Short-chain dehydrogenase reductase Sdr
JVE63_RS05900	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JVE63_RS05905	COG1201	RNA secondary structure unwinding
JVE63_RS05930	COG0628	permease
JVE63_RS05940	COG0326	Molecular chaperone. Has ATPase activity
JVE63_RS05945	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JVE63_RS05970	COG0765	amino acid transport
JVE63_RS05975	COG0765	amino acid transport
JVE63_RS05980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JVE63_RS05985	COG1126	abc transporter atp-binding protein
JVE63_RS05990	COG0745	RESPONSE REGULATOR receiver
JVE63_RS05995	COG2205	protein histidine kinase activity
JVE63_RS06000	COG2358	TRAP transporter, solute receptor (TAXI family
JVE63_RS06005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JVE63_RS06025	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JVE63_RS06035	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JVE63_RS06040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JVE63_RS06050	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JVE63_RS06070	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JVE63_RS06075	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JVE63_RS06080	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JVE63_RS06115	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JVE63_RS06150	COG2186	Transcriptional regulator
JVE63_RS06155	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JVE63_RS06170	COG0187	DNA topoisomerase II activity
JVE63_RS06175	COG4585	Histidine kinase
JVE63_RS06180	COG2197	response regulator
JVE63_RS06185	COG4565	transcriptional regulatory protein
JVE63_RS06190	COG3290	protein histidine kinase activity
JVE63_RS06200	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JVE63_RS06205	COG0612	Peptidase, M16
JVE63_RS06215	COG1196	nuclear chromosome segregation
JVE63_RS06215	COG0739	heme binding
JVE63_RS06215	COG0741	lytic transglycosylase activity
JVE63_RS06220	COG1802	Transcriptional regulator
JVE63_RS06225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JVE63_RS06245	COG1435	thymidine kinase activity
JVE63_RS06270	COG3903	Transcriptional regulator
JVE63_RS06270	COG3629	intracellular signal transduction
JVE63_RS06360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JVE63_RS06400	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
JVE63_RS06425	COG2271	Major facilitator Superfamily
JVE63_RS06430	COG0183	Belongs to the thiolase family
JVE63_RS06435	COG1028	Short-chain dehydrogenase reductase Sdr
JVE63_RS06440	COG0183	Belongs to the thiolase family
JVE63_RS06445	COG1946	Acyl-CoA thioesterase
JVE63_RS06450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JVE63_RS06460	COG1028	Short-chain dehydrogenase reductase Sdr
JVE63_RS06470	COG2030	dehydratase
JVE63_RS06480	COG1733	regulation of RNA biosynthetic process
JVE63_RS06500	COG1846	Transcriptional regulator
JVE63_RS06535	COG2813	Specifically methylates the guanine in position
JVE63_RS06555	COG3903	Transcriptional regulator
JVE63_RS06555	COG3629	intracellular signal transduction
JVE63_RS06565	COG1132	(ABC) transporter
JVE63_RS06635	COG1595	DNA-templated transcription, initiation
JVE63_RS06645	COG0596	Alpha beta hydrolase
JVE63_RS06675	COG0803	Belongs to the bacterial solute-binding protein 9 family
JVE63_RS06685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JVE63_RS06690	COG1120	ATPase activity
JVE63_RS06745	COG1857	crispr-associated protein
JVE63_RS06760	COG1518	maintenance of DNA repeat elements
JVE63_RS06765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JVE63_RS06955	COG0791	NLP P60 protein
JVE63_RS06955	COG3883	PFAM NLP P60 protein
JVE63_RS07190	COG3415	Transposase
JVE63_RS07190	COG2801	Transposase and inactivated derivatives
JVE63_RS07220	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JVE63_RS07245	COG0039	L-malate dehydrogenase activity
JVE63_RS07300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JVE63_RS07305	COG0531	amino acid
JVE63_RS07310	COG0569	domain protein
JVE63_RS07320	COG1136	(ABC) transporter
JVE63_RS07355	COG1136	(ABC) transporter
JVE63_RS07355	COG4591	ABC-type transport system involved in lipoprotein release permease component
JVE63_RS07365	COG0756	dUTP diphosphatase activity
JVE63_RS07390	COG2205	protein histidine kinase activity
JVE63_RS07395	COG0745	RESPONSE REGULATOR receiver
JVE63_RS07405	COG0483	inositol monophosphate 1-phosphatase activity
JVE63_RS07410	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JVE63_RS07435	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JVE63_RS07445	COG3903	Transcriptional regulator
JVE63_RS07445	COG3629	intracellular signal transduction
JVE63_RS07450	COG1799	cell septum assembly
JVE63_RS07475	COG2040	homocysteine
JVE63_RS07485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JVE63_RS07490	COG2235	arginine
JVE63_RS07495	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JVE63_RS07500	COG1024	Enoyl-CoA hydratase
JVE63_RS07550	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
JVE63_RS07580	COG3201	nicotinamide mononucleotide transporter
JVE63_RS07590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JVE63_RS07600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JVE63_RS07610	COG4585	Histidine kinase
JVE63_RS07615	COG2197	response regulator
JVE63_RS07620	COG0577	efflux transmembrane transporter activity
JVE63_RS07620	COG1136	(ABC) transporter
JVE63_RS07625	COG0577	efflux transmembrane transporter activity
JVE63_RS07630	COG1073	alpha beta
JVE63_RS07640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JVE63_RS07650	COG1902	pentaerythritol trinitrate reductase activity
JVE63_RS07655	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
JVE63_RS07665	COG1653	transport
JVE63_RS07670	COG1175	transmembrane transport
JVE63_RS07675	COG0395	ABC-type sugar transport system, permease component
JVE63_RS07680	COG1940	carbohydrate kinase activity
JVE63_RS07685	COG4213	ABC transporter substrate-binding protein
JVE63_RS07695	COG4214	carbohydrate transport
JVE63_RS07700	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JVE63_RS07705	COG0531	amino acid
JVE63_RS07715	COG1250	3-hydroxyacyl-CoA dehydrogenase
JVE63_RS07715	COG1024	Enoyl-CoA hydratase
JVE63_RS07720	COG0183	Belongs to the thiolase family
JVE63_RS07725	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
JVE63_RS07740	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JVE63_RS07745	COG0446	pyridine nucleotide-disulphide oxidoreductase
JVE63_RS07755	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
JVE63_RS07760	COG3253	May function as heme-dependent peroxidase
JVE63_RS07790	COG3220	belongs to the UPF0276 family
JVE63_RS07845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JVE63_RS07850	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JVE63_RS07905	COG1175	transmembrane transport
JVE63_RS07920	COG2409	Drug exporters of the RND superfamily
JVE63_RS07940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JVE63_RS07945	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
JVE63_RS07965	COG0529	Catalyzes the synthesis of activated sulfate
JVE63_RS07970	COG0175	sulfate reduction
JVE63_RS07980	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JVE63_RS07995	COG1960	acyl-CoA dehydrogenase activity
JVE63_RS08035	COG1595	DNA-templated transcription, initiation
JVE63_RS08055	COG3290	protein histidine kinase activity
JVE63_RS08080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JVE63_RS08085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JVE63_RS08110	COG0346	lactoylglutathione lyase activity
JVE63_RS08125	COG1162	GTPase activity
JVE63_RS08145	COG0028	Belongs to the TPP enzyme family
JVE63_RS08165	COG1802	Transcriptional regulator
JVE63_RS08175	COG3842	ATPase activity
JVE63_RS08180	COG1175	transmembrane transport
JVE63_RS08185	COG1840	ABC-type Fe3 transport system, periplasmic component
JVE63_RS08190	COG3835	regulator
JVE63_RS08205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JVE63_RS08235	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JVE63_RS08245	COG0745	RESPONSE REGULATOR receiver
JVE63_RS08250	COG2205	protein histidine kinase activity
JVE63_RS08255	COG2124	cytochrome p450
JVE63_RS08260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JVE63_RS08375	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JVE63_RS08425	COG2197	response regulator
JVE63_RS08430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JVE63_RS08435	COG0318	PFAM AMP-dependent synthetase and ligase
JVE63_RS08450	COG3960	tartronate-semialdehyde synthase activity
JVE63_RS08460	COG2084	Dehydrogenase
JVE63_RS08465	COG3622	Belongs to the hyi family
JVE63_RS08485	COG2351	hydroxyisourate hydrolase activity
JVE63_RS08500	COG2233	PERMEase
JVE63_RS08515	COG1132	(ABC) transporter
JVE63_RS08520	COG1132	(ABC) transporter
JVE63_RS08525	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
JVE63_RS08530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JVE63_RS08535	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JVE63_RS08540	COG1120	ATPase activity
JVE63_RS08565	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
JVE63_RS08585	COG1414	Transcriptional regulator
JVE63_RS08590	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JVE63_RS08595	COG4266	Belongs to the allantoicase family
JVE63_RS08610	COG2197	response regulator
JVE63_RS08620	COG0673	inositol 2-dehydrogenase activity
JVE63_RS08625	COG2188	Transcriptional regulator
JVE63_RS08640	COG1129	ABC transporter
JVE63_RS08645	COG1940	carbohydrate kinase activity
JVE63_RS08655	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JVE63_RS08675	COG1126	abc transporter atp-binding protein
JVE63_RS08680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JVE63_RS08685	COG0765	amino acid transport
JVE63_RS08690	COG0765	amino acid transport
JVE63_RS08695	COG0405	Gamma-glutamyltransferase
JVE63_RS08730	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JVE63_RS08740	COG0667	Aldo Keto reductase
JVE63_RS08805	COG0628	permease
JVE63_RS08820	COG0095	Lipoate-protein ligase
JVE63_RS08830	COG0483	inositol monophosphate 1-phosphatase activity
JVE63_RS08865	COG0494	nUDIX hydrolase
JVE63_RS08875	COG1929	Belongs to the glycerate kinase type-1 family
JVE63_RS08885	COG0688	phosphatidylethanolamine metabolic process
JVE63_RS08890	COG1960	acyl-CoA dehydrogenase activity
JVE63_RS08900	COG2301	Belongs to the HpcH HpaI aldolase family
JVE63_RS08905	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JVE63_RS08905	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JVE63_RS08910	COG0604	alcohol dehydrogenase
JVE63_RS08915	COG0442	prolyl-tRNA aminoacylation
JVE63_RS08930	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JVE63_RS08935	COG0750	zinc metalloprotease
JVE63_RS08940	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JVE63_RS08960	COG2508	Transcriptional regulator
JVE63_RS08990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JVE63_RS08995	COG1177	transmembrane transport
JVE63_RS09000	COG1176	ABC-type spermidine putrescine transport system, permease component I
JVE63_RS09005	COG3842	ATPase activity
JVE63_RS09015	COG1012	belongs to the aldehyde dehydrogenase family
JVE63_RS09025	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JVE63_RS09040	COG4585	Histidine kinase
JVE63_RS09045	COG2197	response regulator
JVE63_RS09055	COG1012	belongs to the aldehyde dehydrogenase family
JVE63_RS09065	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JVE63_RS09070	COG1136	(ABC) transporter
JVE63_RS09085	COG3842	ATPase activity
JVE63_RS09100	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JVE63_RS09105	COG0575	Belongs to the CDS family
JVE63_RS09110	COG0233	cytoplasmic translational termination
JVE63_RS09115	COG0528	UMP kinase activity
JVE63_RS09120	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JVE63_RS09125	COG0052	Belongs to the universal ribosomal protein uS2 family
JVE63_RS09140	COG1191	sigma factor activity
JVE63_RS09155	COG0792	nuclease activity
JVE63_RS09170	COG0681	Belongs to the peptidase S26 family
JVE63_RS09180	COG0681	Belongs to the peptidase S26 family
JVE63_RS09190	COG0335	large ribosomal subunit rRNA binding
JVE63_RS09195	COG0336	Belongs to the RNA methyltransferase TrmD family
JVE63_RS09200	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JVE63_RS09205	COG1837	Belongs to the UPF0109 family
JVE63_RS09210	COG0228	four-way junction DNA binding
JVE63_RS09220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JVE63_RS09230	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
JVE63_RS09260	COG4552	Acetyltransferase involved in intracellular survival and related
JVE63_RS09275	COG0477	Major facilitator Superfamily
JVE63_RS09280	COG1196	nuclear chromosome segregation
JVE63_RS09290	COG1254	Belongs to the acylphosphatase family
JVE63_RS09300	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JVE63_RS09305	COG0571	ribonuclease III activity
JVE63_RS09310	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JVE63_RS09325	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JVE63_RS09330	COG0742	ribosomal rna small subunit methyltransferase
JVE63_RS09345	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JVE63_RS09350	COG0351	phosphomethylpyrimidine kinase
JVE63_RS09370	COG1181	Belongs to the D-alanine--D-alanine ligase family
JVE63_RS09375	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JVE63_RS09385	COG1920	GTP binding
JVE63_RS09395	COG0776	regulation of translation
JVE63_RS09405	COG0066	3-isopropylmalate dehydratase activity
JVE63_RS09410	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JVE63_RS09415	COG1414	Transcriptional regulator
JVE63_RS09435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JVE63_RS09440	COG0179	Fumarylacetoacetate (FAA) hydrolase
JVE63_RS09450	COG5002	protein histidine kinase activity
JVE63_RS09455	COG2018	Roadblock/LC7 domain
JVE63_RS09475	COG2018	Roadblock/LC7 domain
JVE63_RS09495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JVE63_RS09500	COG5492	domain, Protein
JVE63_RS09505	COG2353	YceI-like domain
JVE63_RS09525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JVE63_RS09530	COG0477	Major facilitator Superfamily
JVE63_RS09545	COG2957	Belongs to the agmatine deiminase family
JVE63_RS09550	COG0804	urea catabolic process
JVE63_RS09555	COG0832	Belongs to the urease beta subunit family
JVE63_RS09555	COG0831	urea catabolic process
JVE63_RS09565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JVE63_RS09570	COG0473	3-isopropylmalate dehydrogenase activity
JVE63_RS09585	COG0575	Belongs to the CDS family
JVE63_RS09600	COG0640	Transcriptional regulator
JVE63_RS09610	COG0662	Cupin 2, conserved barrel domain protein
JVE63_RS09630	COG1012	belongs to the aldehyde dehydrogenase family
JVE63_RS09635	COG0506	proline dehydrogenase activity
JVE63_RS09640	COG3835	regulator
JVE63_RS09650	COG0477	Major facilitator Superfamily
JVE63_RS09655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JVE63_RS09660	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JVE63_RS09665	COG0440	acetolactate synthase activity
JVE63_RS09685	COG0667	Aldo Keto reductase
JVE63_RS09700	COG2197	response regulator
JVE63_RS09715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JVE63_RS09720	COG2409	Drug exporters of the RND superfamily
JVE63_RS09730	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JVE63_RS09740	COG0154	amidase activity
JVE63_RS09745	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JVE63_RS09755	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JVE63_RS09770	COG1611	Belongs to the LOG family
JVE63_RS09780	COG0482	sulfurtransferase activity
JVE63_RS09800	COG2860	membrane
JVE63_RS09805	COG4608	Belongs to the ABC transporter superfamily
JVE63_RS09810	COG0444	Belongs to the ABC transporter superfamily
JVE63_RS09820	COG0747	negative chemotaxis
JVE63_RS09825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JVE63_RS09845	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JVE63_RS09850	COG0509	glycine decarboxylation via glycine cleavage system
JVE63_RS09855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JVE63_RS09860	COG1760	l-serine dehydratase
JVE63_RS09900	COG0791	NLP P60 protein
JVE63_RS09955	COG3344	reverse transcriptase
JVE63_RS09980	COG0305	Participates in initiation and elongation during chromosome replication
JVE63_RS10110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JVE63_RS10130	COG0494	nUDIX hydrolase
JVE63_RS10185	COG1760	l-serine dehydratase
JVE63_RS10210	COG1902	pentaerythritol trinitrate reductase activity
JVE63_RS10215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JVE63_RS10225	COG1309	transcriptional regulator
JVE63_RS10300	COG1132	(ABC) transporter
JVE63_RS10305	COG1132	(ABC) transporter
JVE63_RS10315	COG2197	response regulator
JVE63_RS10320	COG4585	Histidine kinase
JVE63_RS10325	COG0058	SHG alpha-glucan phosphorylase activity
JVE63_RS10340	COG2368	4-hydroxyphenylacetate
JVE63_RS10355	COG0366	Alpha amylase catalytic
JVE63_RS10360	COG0366	Alpha amylase catalytic
JVE63_RS10375	COG3634	alkyl hydroperoxide reductase activity
JVE63_RS10390	COG0789	Transcriptional regulator
JVE63_RS10400	COG1301	dicarboxylic acid transport
JVE63_RS10405	COG3290	protein histidine kinase activity
JVE63_RS10410	COG4565	transcriptional regulatory protein
JVE63_RS10415	COG2267	carboxylic ester hydrolase activity
JVE63_RS10420	COG0205	6-phosphofructokinase activity
JVE63_RS10425	COG0857	belongs to the CobB CobQ family
JVE63_RS10425	COG0280	phosphate acetyltransferase
JVE63_RS10430	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JVE63_RS10460	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JVE63_RS10460	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JVE63_RS10500	COG2205	protein histidine kinase activity
JVE63_RS10505	COG0745	RESPONSE REGULATOR receiver
JVE63_RS10525	COG0183	Belongs to the thiolase family
JVE63_RS10585	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
JVE63_RS10600	COG1250	3-hydroxyacyl-CoA dehydrogenase
JVE63_RS10620	COG4585	Histidine kinase
JVE63_RS10625	COG2197	response regulator
JVE63_RS10640	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JVE63_RS10645	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JVE63_RS10650	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JVE63_RS10655	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JVE63_RS10660	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JVE63_RS10665	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JVE63_RS10670	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JVE63_RS10690	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JVE63_RS10695	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JVE63_RS10705	COG2890	protein-(glutamine-N5) methyltransferase activity
JVE63_RS10710	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JVE63_RS10715	COG0254	rRNA binding
JVE63_RS10720	COG1316	TRANSCRIPTIONal
JVE63_RS10730	COG0083	homoserine kinase activity
JVE63_RS10735	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JVE63_RS10740	COG0460	homoserine dehydrogenase
JVE63_RS10745	COG0019	diaminopimelate decarboxylase activity
JVE63_RS10750	COG0018	arginyl-trna synthetase
JVE63_RS10770	COG0515	serine threonine protein kinase
JVE63_RS10810	COG1802	Transcriptional regulator
JVE63_RS10845	COG1404	Belongs to the peptidase S8 family
JVE63_RS10850	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
JVE63_RS10855	COG1793	dna ligase
JVE63_RS10855	COG3285	dna ligase
JVE63_RS10885	COG2205	protein histidine kinase activity
JVE63_RS10895	COG0768	penicillin binding
JVE63_RS10970	COG1357	PFAM Pentapeptide repeats (8 copies)
JVE63_RS10975	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JVE63_RS10990	COG1595	DNA-templated transcription, initiation
JVE63_RS11020	COG0745	RESPONSE REGULATOR receiver
JVE63_RS11025	COG2205	protein histidine kinase activity
JVE63_RS11030	COG0508	dehydrogenase complex catalyzes the overall conversion of
JVE63_RS11030	COG0567	Dehydrogenase, E1 component
JVE63_RS11040	COG2255	four-way junction helicase activity
JVE63_RS11085	COG0604	alcohol dehydrogenase
JVE63_RS11100	COG0765	amino acid transport
JVE63_RS11115	COG1595	DNA-templated transcription, initiation
JVE63_RS11120	COG4106	trans-aconitate 2-methyltransferase activity
JVE63_RS11170	COG0142	geranyltranstransferase activity
JVE63_RS11205	COG1597	lipid kinase activity
JVE63_RS11220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JVE63_RS11225	COG1472	Belongs to the glycosyl hydrolase 3 family
JVE63_RS11230	COG0395	ABC-type sugar transport system, permease component
JVE63_RS11235	COG1175	transmembrane transport
JVE63_RS11240	COG2182	Extracellular solute-binding protein
JVE63_RS11245	COG2188	Transcriptional regulator
JVE63_RS11260	COG0242	peptide deformylase activity
JVE63_RS11280	COG5662	AntiSigma factor
JVE63_RS11285	COG1595	DNA-templated transcription, initiation
JVE63_RS11295	COG2135	peptidase activity
JVE63_RS11305	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JVE63_RS11315	COG2076	Multidrug Resistance protein
JVE63_RS11320	COG0483	inositol monophosphate 1-phosphatase activity
JVE63_RS11335	COG0753	catalase activity
JVE63_RS11360	COG1615	UPF0182 protein
JVE63_RS11370	COG3480	Lon protease (S16) C-terminal proteolytic domain
JVE63_RS11425	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JVE63_RS11470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JVE63_RS11475	COG0210	DNA helicase
JVE63_RS11535	COG0596	Alpha beta hydrolase
JVE63_RS11535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JVE63_RS11565	COG0513	Belongs to the DEAD box helicase family
JVE63_RS11580	COG2095	MarC family integral membrane protein
JVE63_RS11600	COG0598	Magnesium transport protein CorA
JVE63_RS11635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JVE63_RS11640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JVE63_RS11650	COG1595	DNA-templated transcription, initiation
JVE63_RS11665	COG1024	Enoyl-CoA hydratase
JVE63_RS11670	COG2818	Glycosylase
JVE63_RS11680	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JVE63_RS11685	COG1611	Belongs to the LOG family
JVE63_RS11690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JVE63_RS11735	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JVE63_RS11750	COG4608	Belongs to the ABC transporter superfamily
JVE63_RS11760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JVE63_RS11765	COG0601	transmembrane transport
JVE63_RS11780	COG4608	Belongs to the ABC transporter superfamily
JVE63_RS11785	COG0444	Belongs to the ABC transporter superfamily
JVE63_RS11790	COG0601	transmembrane transport
JVE63_RS11795	COG4166	transmembrane transport
JVE63_RS11800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JVE63_RS11805	COG1217	gtp-binding protein TYPA
JVE63_RS11825	COG1053	succinate dehydrogenase
JVE63_RS11840	COG1842	Phage shock protein A
JVE63_RS11895	COG0012	GTP binding
JVE63_RS11910	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JVE63_RS11915	COG0531	amino acid
JVE63_RS11920	COG1570	exodeoxyribonuclease VII activity
JVE63_RS11925	COG1722	exodeoxyribonuclease VII activity
JVE63_RS11930	COG0778	Nitroreductase
JVE63_RS11960	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
JVE63_RS11960	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
JVE63_RS11970	COG0114	fumarate hydratase activity
JVE63_RS11990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JVE63_RS12025	COG1136	(ABC) transporter
JVE63_RS12035	COG0450	alkyl hydroperoxide reductase
JVE63_RS12040	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JVE63_RS12060	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
JVE63_RS12065	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JVE63_RS12070	COG0667	Aldo Keto reductase
JVE63_RS12075	COG1733	regulation of RNA biosynthetic process
JVE63_RS12095	COG3903	Transcriptional regulator
JVE63_RS12095	COG3629	intracellular signal transduction
JVE63_RS12105	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
JVE63_RS12150	COG1476	TRANSCRIPTIONal
JVE63_RS12160	COG1131	(ABC) transporter
JVE63_RS12165	COG2124	cytochrome p450
JVE63_RS12180	COG2867	negative regulation of translational initiation
JVE63_RS12190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JVE63_RS12195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JVE63_RS12210	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JVE63_RS12225	COG1960	acyl-CoA dehydrogenase activity
JVE63_RS12255	COG4638	Rieske (2fe-2S)
JVE63_RS12315	COG2885	chlorophyll binding
JVE63_RS12365	COG2894	cell division
JVE63_RS12390	COG0642	Histidine kinase
JVE63_RS12415	COG2124	cytochrome p450
JVE63_RS12425	COG0583	DNA-binding transcription factor activity
JVE63_RS12435	COG1215	transferase activity, transferring glycosyl groups
JVE63_RS12490	COG0110	maltose O-acetyltransferase activity
JVE63_RS12495	COG2610	gluconate transmembrane transporter activity
JVE63_RS12500	COG0251	oxidation-reduction process
JVE63_RS12505	COG1414	Transcriptional regulator
JVE63_RS12520	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
JVE63_RS12535	COG2304	oxidoreductase activity
JVE63_RS12595	COG0438	transferase activity, transferring glycosyl groups
JVE63_RS12615	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JVE63_RS12680	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
JVE63_RS12695	COG0463	Glycosyl transferase, family 2
JVE63_RS12710	COG1331	Highly conserved protein containing a thioredoxin domain
JVE63_RS12725	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JVE63_RS12735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JVE63_RS12750	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JVE63_RS12760	COG1595	DNA-templated transcription, initiation
JVE63_RS12785	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JVE63_RS12800	COG0488	(ABC) transporter
JVE63_RS12810	COG1376	ErfK ybiS ycfS ynhG family protein
JVE63_RS12820	COG2986	histidine ammonia-lyase
JVE63_RS12830	COG1024	Enoyl-CoA hydratase
JVE63_RS12845	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JVE63_RS12855	COG0424	maF-like protein
JVE63_RS12860	COG4770	biotin carboxylase activity
JVE63_RS12885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JVE63_RS12900	COG2814	Major facilitator Superfamily
JVE63_RS12920	COG1012	belongs to the aldehyde dehydrogenase family
JVE63_RS12925	COG1012	belongs to the aldehyde dehydrogenase family
JVE63_RS12935	COG1595	DNA-templated transcription, initiation
JVE63_RS12940	COG0745	RESPONSE REGULATOR receiver
JVE63_RS12945	COG2205	protein histidine kinase activity
JVE63_RS12970	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JVE63_RS12980	COG0583	DNA-binding transcription factor activity
JVE63_RS12985	COG2814	Major facilitator Superfamily
JVE63_RS13015	COG1079	Belongs to the binding-protein-dependent transport system permease family
JVE63_RS13020	COG4603	Belongs to the binding-protein-dependent transport system permease family
JVE63_RS13025	COG3845	ABC transporter
JVE63_RS13030	COG1744	ABC transporter substrate-binding protein PnrA-like
JVE63_RS13035	COG1473	amidohydrolase
JVE63_RS13035	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
JVE63_RS13065	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JVE63_RS13065	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JVE63_RS13080	COG1595	DNA-templated transcription, initiation
JVE63_RS13140	COG2009	succinate dehydrogenase
JVE63_RS13150	COG1053	succinate dehydrogenase
JVE63_RS13155	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JVE63_RS13180	COG1309	transcriptional regulator
JVE63_RS13185	COG2409	Drug exporters of the RND superfamily
JVE63_RS13190	COG0745	RESPONSE REGULATOR receiver
JVE63_RS13195	COG2205	protein histidine kinase activity
JVE63_RS13200	COG1408	metallophosphoesterase
JVE63_RS13210	COG1686	Belongs to the peptidase S11 family
JVE63_RS13245	COG0180	Tryptophanyl-tRNA synthetase
JVE63_RS13250	COG1595	DNA-templated transcription, initiation
JVE63_RS13265	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JVE63_RS13270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JVE63_RS13280	COG4221	oxidoreductase activity
JVE63_RS13285	COG0039	L-malate dehydrogenase activity
JVE63_RS13300	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JVE63_RS13310	COG0138	bifunctional purine biosynthesis protein purh
JVE63_RS13340	COG0045	succinate-CoA ligase (ADP-forming) activity
JVE63_RS13345	COG3552	Protein containing von Willebrand factor type A (VWA) domain
JVE63_RS13350	COG2425	protein containing a von Willebrand factor type A (vWA) domain
JVE63_RS13355	COG0714	Associated with various cellular activities
JVE63_RS13370	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JVE63_RS13370	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JVE63_RS13380	COG0739	heme binding
JVE63_RS13400	COG2197	response regulator
JVE63_RS13430	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JVE63_RS13430	COG0519	Catalyzes the synthesis of GMP from XMP
JVE63_RS13450	COG1012	belongs to the aldehyde dehydrogenase family
JVE63_RS13470	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JVE63_RS13485	COG0516	GMP reductase activity
JVE63_RS13495	COG1595	DNA-templated transcription, initiation
JVE63_RS13500	COG2197	response regulator
JVE63_RS13510	COG0583	DNA-binding transcription factor activity
JVE63_RS13520	COG4221	oxidoreductase activity
JVE63_RS13525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JVE63_RS13530	COG0459	protein refolding
JVE63_RS13545	COG0726	polysaccharide deacetylase
JVE63_RS13560	COG4941	Belongs to the sigma-70 factor family
JVE63_RS13575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JVE63_RS13600	COG0802	atpase or kinase
JVE63_RS13610	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JVE63_RS13630	COG0736	holo-[acyl-carrier-protein] synthase activity
JVE63_RS13635	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JVE63_RS13640	COG1072	(Pantothenic acid kinase))
JVE63_RS13665	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JVE63_RS13695	COG0640	Transcriptional regulator
JVE63_RS13710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JVE63_RS13715	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JVE63_RS13720	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JVE63_RS13725	COG0488	(ABC) transporter
JVE63_RS13735	COG0101	tRNA pseudouridine synthase activity
JVE63_RS13740	COG0203	ribosomal protein L17
JVE63_RS13745	COG0202	RNA polymerase activity
JVE63_RS13750	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JVE63_RS13755	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JVE63_RS13760	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JVE63_RS13765	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JVE63_RS13775	COG0563	adenylate kinase activity
JVE63_RS13785	COG0200	Binds to the 23S rRNA
JVE63_RS13790	COG1841	ribosomal large subunit assembly
JVE63_RS13795	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JVE63_RS13800	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JVE63_RS13805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JVE63_RS13810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JVE63_RS13815	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JVE63_RS13820	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JVE63_RS13825	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JVE63_RS13830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JVE63_RS13835	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JVE63_RS13840	COG0255	Belongs to the universal ribosomal protein uL29 family
JVE63_RS13845	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JVE63_RS13850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JVE63_RS13855	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JVE63_RS13860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JVE63_RS13865	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JVE63_RS13870	COG0089	rRNA binding
JVE63_RS13875	COG0088	Forms part of the polypeptide exit tunnel
JVE63_RS13880	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JVE63_RS13885	COG0051	transcription antitermination factor activity, RNA binding
JVE63_RS13910	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JVE63_RS13915	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JVE63_RS13920	COG0049	tRNA binding
JVE63_RS13925	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JVE63_RS14025	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JVE63_RS14030	COG0085	RNA polymerase activity
JVE63_RS14035	COG0222	ribosome binding
JVE63_RS14040	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JVE63_RS14050	COG0081	regulation of translation
JVE63_RS14055	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JVE63_RS14065	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JVE63_RS14075	COG0436	Aminotransferase
JVE63_RS14080	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JVE63_RS14085	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JVE63_RS14090	COG0477	Major facilitator Superfamily
JVE63_RS14105	COG2030	dehydratase
JVE63_RS14110	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JVE63_RS14130	COG0702	epimerase
JVE63_RS14140	COG1434	Gram-negative-bacterium-type cell wall biogenesis
JVE63_RS14150	COG2188	Transcriptional regulator
JVE63_RS14170	COG1051	belongs to the nudix hydrolase family
JVE63_RS14170	COG1056	cytidyltransferase-related domain
JVE63_RS14225	COG1666	GTP binding
JVE63_RS14230	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JVE63_RS14245	COG3304	Inner membrane component domain
JVE63_RS14250	COG0501	Belongs to the peptidase M48B family
JVE63_RS14255	COG1007	ATP synthesis coupled electron transport
JVE63_RS14270	COG0713	ATP synthesis coupled electron transport
JVE63_RS14275	COG0839	Belongs to the complex I subunit 6 family
JVE63_RS14280	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JVE63_RS14285	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
JVE63_RS14295	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JVE63_RS14300	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JVE63_RS14320	COG0674	pyruvate-flavodoxin oxidoreductase activity
JVE63_RS14320	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JVE63_RS14325	COG1013	pyruvate-flavodoxin oxidoreductase activity
JVE63_RS14350	COG1733	regulation of RNA biosynthetic process
JVE63_RS14365	COG2234	aminopeptidase activity
JVE63_RS14365	COG4935	Belongs to the peptidase S8 family
JVE63_RS14390	COG0142	geranyltranstransferase activity
JVE63_RS14400	COG0179	Fumarylacetoacetate (FAA) hydrolase
JVE63_RS14405	COG1007	ATP synthesis coupled electron transport
JVE63_RS14415	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JVE63_RS14420	COG0713	ATP synthesis coupled electron transport
JVE63_RS14425	COG0839	Belongs to the complex I subunit 6 family
JVE63_RS14430	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JVE63_RS14435	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
JVE63_RS14440	COG1034	ATP synthesis coupled electron transport
JVE63_RS14445	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
JVE63_RS14455	COG0649	NAD binding
JVE63_RS14460	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JVE63_RS14465	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JVE63_RS14480	COG1028	Short-chain dehydrogenase reductase Sdr
JVE63_RS14510	COG2226	methyltransferase
JVE63_RS14520	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
JVE63_RS14530	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
JVE63_RS14535	COG1278	Cold shock
JVE63_RS14565	COG1301	dicarboxylic acid transport
JVE63_RS14580	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
JVE63_RS14590	COG0163	prenyltransferase activity
JVE63_RS14605	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
JVE63_RS14615	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JVE63_RS14620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JVE63_RS14645	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JVE63_RS14650	COG1333	cytochrome c biogenesis protein
JVE63_RS14670	COG0406	alpha-ribazole phosphatase activity
JVE63_RS14675	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JVE63_RS14695	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JVE63_RS14705	COG4977	sequence-specific DNA binding
JVE63_RS14735	COG1742	UPF0060 membrane protein
JVE63_RS14745	COG1690	Belongs to the RtcB family
JVE63_RS14785	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
JVE63_RS14790	COG0018	arginyl-trna synthetase
JVE63_RS14805	COG2319	Wd-40 repeat
JVE63_RS14815	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JVE63_RS14845	COG0702	epimerase
JVE63_RS14860	COG0113	porphobilinogen synthase activity
JVE63_RS14875	COG1648	precorrin-2 dehydrogenase activity
JVE63_RS14875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JVE63_RS14880	COG0181	hydroxymethylbilane synthase activity
JVE63_RS14885	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JVE63_RS14890	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
JVE63_RS14945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JVE63_RS14965	COG0180	Tryptophanyl-tRNA synthetase
JVE63_RS14970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JVE63_RS14980	COG1129	ABC transporter
JVE63_RS14980	COG0842	Transport permease protein
JVE63_RS14990	COG1595	DNA-templated transcription, initiation
JVE63_RS15005	COG4991	sh3 domain protein
JVE63_RS15010	COG0515	serine threonine protein kinase
JVE63_RS15010	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JVE63_RS15015	COG0129	dihydroxy-acid dehydratase activity
JVE63_RS15025	COG1082	Xylose isomerase domain protein TIM barrel
JVE63_RS15030	COG0248	Ppx GppA phosphatase
JVE63_RS15050	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
JVE63_RS15060	COG0671	phosphoesterase, PA-phosphatase related
JVE63_RS15065	COG1194	a g-specific adenine glycosylase
JVE63_RS15070	COG1595	DNA-templated transcription, initiation
JVE63_RS15080	COG0745	RESPONSE REGULATOR receiver
JVE63_RS15085	COG2205	protein histidine kinase activity
JVE63_RS15090	COG0739	heme binding
JVE63_RS15125	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JVE63_RS15145	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
JVE63_RS15155	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
JVE63_RS15160	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JVE63_RS15170	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
JVE63_RS15185	COG0640	Transcriptional regulator
JVE63_RS15190	COG1660	Displays ATPase and GTPase activities
JVE63_RS15195	COG2197	response regulator
JVE63_RS15210	COG0649	NAD binding
JVE63_RS15225	COG1174	glycine betaine transport
JVE63_RS15235	COG0517	IMP dehydrogenase activity
JVE63_RS15235	COG1125	glycine betaine transport
JVE63_RS15245	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JVE63_RS15245	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
JVE63_RS15260	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JVE63_RS15290	COG0181	hydroxymethylbilane synthase activity
JVE63_RS15295	COG1725	Transcriptional regulator
JVE63_RS15320	COG0302	gtp cyclohydrolase
JVE63_RS15345	COG2027	D-alanyl-D-alanine carboxypeptidase
JVE63_RS15350	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JVE63_RS15360	COG0586	Pfam SNARE associated Golgi protein
JVE63_RS15365	COG0393	Putative heavy-metal-binding
JVE63_RS15370	COG0076	glutamate decarboxylase activity
JVE63_RS15395	COG2318	DinB family
JVE63_RS15400	COG1012	belongs to the aldehyde dehydrogenase family
JVE63_RS15445	COG1335	isochorismatase
JVE63_RS15475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JVE63_RS15490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JVE63_RS15490	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JVE63_RS15495	COG4977	sequence-specific DNA binding
JVE63_RS15545	COG1132	(ABC) transporter
JVE63_RS15580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JVE63_RS15585	COG0587	DNA-directed DNA polymerase activity
JVE63_RS15620	COG0583	DNA-binding transcription factor activity
JVE63_RS15700	COG2208	phosphoserine phosphatase activity
JVE63_RS15700	COG2172	sigma factor antagonist activity
JVE63_RS15700	COG1366	Belongs to the anti-sigma-factor antagonist family
JVE63_RS15710	COG0531	amino acid
JVE63_RS15715	COG1404	Belongs to the peptidase S8 family
JVE63_RS15730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JVE63_RS15765	COG0747	negative chemotaxis
JVE63_RS15775	COG0601	transmembrane transport
JVE63_RS15790	COG1012	belongs to the aldehyde dehydrogenase family
JVE63_RS15840	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JVE63_RS15890	COG0596	Alpha beta hydrolase
JVE63_RS15895	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JVE63_RS15900	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JVE63_RS15905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JVE63_RS15905	COG1754	DNA topoisomerase type I activity
JVE63_RS15915	COG2264	protein methyltransferase activity
JVE63_RS15925	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
JVE63_RS15935	COG1366	Belongs to the anti-sigma-factor antagonist family
JVE63_RS15940	COG1111	helicase
JVE63_RS15940	COG1205	dead DEAH box helicase
JVE63_RS15945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JVE63_RS15950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JVE63_RS15955	COG0156	8-amino-7-oxononanoate synthase activity
JVE63_RS15970	COG0456	acetyltransferase
JVE63_RS16040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JVE63_RS16045	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JVE63_RS16055	COG2267	carboxylic ester hydrolase activity
JVE63_RS16080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JVE63_RS16105	COG0003	Pfam Anion-transporting ATPase
JVE63_RS16115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JVE63_RS16125	COG1408	metallophosphoesterase
JVE63_RS16145	COG1609	Transcriptional regulator
JVE63_RS16205	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JVE63_RS16220	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JVE63_RS16225	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JVE63_RS16235	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
JVE63_RS16285	COG0596	Alpha beta hydrolase
JVE63_RS16330	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JVE63_RS16355	COG1595	DNA-templated transcription, initiation
JVE63_RS16375	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JVE63_RS16380	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JVE63_RS16395	COG0463	Glycosyl transferase, family 2
JVE63_RS16400	COG1802	Transcriptional regulator
JVE63_RS16435	COG0105	UTP biosynthetic process
JVE63_RS16450	COG1434	Gram-negative-bacterium-type cell wall biogenesis
JVE63_RS16470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JVE63_RS16515	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JVE63_RS16515	COG0515	serine threonine protein kinase
JVE63_RS16530	COG0693	protein deglycase activity
JVE63_RS16545	COG2319	Wd-40 repeat
JVE63_RS16545	COG4249	Peptidase C14 caspase catalytic subunit p20
JVE63_RS16555	COG1132	(ABC) transporter
JVE63_RS16570	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JVE63_RS16580	COG4585	Histidine kinase
JVE63_RS16585	COG2197	response regulator
JVE63_RS16600	COG3467	pyridoxamine 5'-phosphate
JVE63_RS16615	COG3844	kynureninase activity
JVE63_RS16635	COG2197	response regulator
JVE63_RS16655	COG0477	Major facilitator Superfamily
JVE63_RS16660	COG0191	fructose-bisphosphate aldolase activity
JVE63_RS16665	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JVE63_RS16680	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
JVE63_RS16710	COG0542	response to heat
JVE63_RS16735	COG0789	Transcriptional regulator
JVE63_RS16740	COG0484	heat shock protein binding
JVE63_RS16745	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JVE63_RS16750	COG0443	Heat shock 70 kDa protein
JVE63_RS16755	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JVE63_RS16760	COG0247	lactate metabolic process
JVE63_RS16760	COG2181	nitrate reductase activity
JVE63_RS16775	COG0717	Belongs to the dCTP deaminase family
JVE63_RS16790	COG1278	Cold shock
JVE63_RS16855	COG2223	nitrite transmembrane transporter activity
JVE63_RS16870	COG2226	methyltransferase
JVE63_RS16905	COG0477	Major facilitator Superfamily
JVE63_RS16915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JVE63_RS16920	COG0798	PFAM Bile acid sodium symporter
JVE63_RS16925	COG0640	Transcriptional regulator
JVE63_RS16965	COG0494	nUDIX hydrolase
JVE63_RS17030	COG1120	ATPase activity
JVE63_RS17040	COG2311	Membrane
JVE63_RS17045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JVE63_RS17075	COG2409	Drug exporters of the RND superfamily
JVE63_RS17105	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
JVE63_RS17115	COG1278	Cold shock
JVE63_RS17135	COG3311	Transcriptional regulator
JVE63_RS17155	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JVE63_RS17190	COG2084	Dehydrogenase
JVE63_RS17260	COG2205	protein histidine kinase activity
JVE63_RS17275	COG0598	Magnesium transport protein CorA
JVE63_RS17305	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JVE63_RS17305	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JVE63_RS17330	COG2264	protein methyltransferase activity
JVE63_RS17335	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JVE63_RS17340	COG0494	nUDIX hydrolase
JVE63_RS17350	COG0745	RESPONSE REGULATOR receiver
JVE63_RS17355	COG2205	protein histidine kinase activity
JVE63_RS17415	COG2409	Drug exporters of the RND superfamily
JVE63_RS17420	COG1846	Transcriptional regulator
JVE63_RS17425	COG2124	cytochrome p450
JVE63_RS17545	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JVE63_RS17550	COG2755	lipolytic protein G-D-S-L family
JVE63_RS17560	COG1741	Belongs to the pirin family
JVE63_RS17570	COG1960	acyl-CoA dehydrogenase activity
JVE63_RS17585	COG1362	aminopeptidase activity
JVE63_RS17625	COG0508	dehydrogenase complex catalyzes the overall conversion of
JVE63_RS17630	COG0022	dehydrogenase e1 component
JVE63_RS17655	COG0515	serine threonine protein kinase
JVE63_RS17660	COG0515	serine threonine protein kinase
JVE63_RS17675	COG1136	(ABC) transporter
JVE63_RS17675	COG4591	ABC-type transport system involved in lipoprotein release permease component
JVE63_RS17745	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JVE63_RS17750	COG0508	dehydrogenase complex catalyzes the overall conversion of
JVE63_RS17765	COG1522	sequence-specific DNA binding
JVE63_RS17795	COG3396	Phenylacetate-CoA oxygenase
JVE63_RS17800	COG3460	Phenylacetate-CoA oxygenase
JVE63_RS17805	COG3396	Phenylacetate-CoA oxygenase
JVE63_RS17810	COG2151	metal-sulfur cluster biosynthetic enzyme
JVE63_RS17815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JVE63_RS17825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JVE63_RS17840	COG2197	response regulator
JVE63_RS17845	COG4585	Histidine kinase
JVE63_RS17855	COG1716	ATPase activity
JVE63_RS17860	COG1716	ATPase activity
JVE63_RS17870	COG0772	Belongs to the SEDS family
JVE63_RS17875	COG0768	penicillin binding
JVE63_RS17880	COG0515	serine threonine protein kinase
JVE63_RS17885	COG3764	Sortase (surface protein transpeptidase)
JVE63_RS17890	COG3764	Sortase (surface protein transpeptidase)
JVE63_RS17905	COG3764	Sortase (surface protein transpeptidase)
JVE63_RS17920	COG0705	Rhomboid family
JVE63_RS17940	COG1595	DNA-templated transcription, initiation
JVE63_RS17960	COG0515	serine threonine protein kinase
JVE63_RS17985	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JVE63_RS17995	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
JVE63_RS18000	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JVE63_RS18005	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
JVE63_RS18010	COG0592	DNA-directed DNA polymerase activity
JVE63_RS18020	COG0230	Belongs to the bacterial ribosomal protein bL34 family
JVE63_RS18025	COG0594	ribonuclease P activity
JVE63_RS18030	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JVE63_RS18035	COG0706	membrane insertase activity
JVE63_RS18045	COG0357	Ribosomal RNA small subunit methyltransferase G
JVE63_RS18050	COG1192	Involved in chromosome partitioning
JVE63_RS18065	COG3118	belongs to the thioredoxin family
JVE63_RS18070	COG0492	ferredoxin-NADP+ reductase activity
JVE63_RS18080	COG1595	DNA-templated transcription, initiation
JVE63_RS18085	COG2815	serine threonine protein kinase
JVE63_RS18085	COG0515	serine threonine protein kinase
JVE63_RS18100	COG0617	tRNA 3'-terminal CCA addition
JVE63_RS18110	COG1260	myo-inositol-1-phosphate synthase
JVE63_RS18120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JVE63_RS18145	COG0360	Binds together with S18 to 16S ribosomal RNA
JVE63_RS18150	COG0629	single-stranded DNA binding
JVE63_RS18155	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JVE63_RS18160	COG0359	binds to the 23S rRNA
JVE63_RS18170	COG0305	Participates in initiation and elongation during chromosome replication
JVE63_RS18210	COG0626	cystathionine gamma-synthase activity
JVE63_RS18215	COG0662	Cupin 2, conserved barrel domain protein
JVE63_RS18240	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JVE63_RS18250	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JVE63_RS18255	COG1609	Transcriptional regulator
JVE63_RS18260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JVE63_RS18265	COG1271	oxidase subunit
JVE63_RS18270	COG1294	oxidase, subunit
JVE63_RS18275	COG4988	ABC transporter
JVE63_RS18285	COG0739	heme binding
JVE63_RS18285	COG0741	lytic transglycosylase activity
JVE63_RS18285	COG1196	nuclear chromosome segregation
JVE63_RS18290	COG0561	phosphatase activity
JVE63_RS18340	COG0561	phosphatase activity
JVE63_RS18345	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JVE63_RS18355	COG2837	iron assimilation
JVE63_RS18360	COG2372	response to copper ion
JVE63_RS18370	COG1999	signal sequence binding
JVE63_RS18395	COG0006	proline dipeptidase activity
JVE63_RS18425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JVE63_RS18455	COG1609	Transcriptional regulator
JVE63_RS18500	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JVE63_RS18555	COG1595	DNA-templated transcription, initiation
JVE63_RS18560	COG0318	PFAM AMP-dependent synthetase and ligase
JVE63_RS18595	COG0477	Major facilitator Superfamily
JVE63_RS18625	COG1191	sigma factor activity
JVE63_RS18675	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JVE63_RS18690	COG0433	COG0433 Predicted ATPase
JVE63_RS18695	COG2234	aminopeptidase activity
JVE63_RS18745	COG1937	Protein conserved in bacteria
JVE63_RS18750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JVE63_RS18760	COG0477	Major facilitator Superfamily
JVE63_RS18780	COG3739	integral membrane protein
JVE63_RS18785	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JVE63_RS18835	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JVE63_RS18850	COG0017	Asparaginyl-tRNA synthetase
JVE63_RS18870	COG0151	Belongs to the GarS family
JVE63_RS18885	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JVE63_RS18895	COG2197	response regulator
JVE63_RS18910	COG1131	(ABC) transporter
JVE63_RS18930	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JVE63_RS18935	COG0047	phosphoribosylformylglycinamidine synthase activity
JVE63_RS18940	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JVE63_RS18970	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JVE63_RS19000	COG1643	Atp-dependent helicase
JVE63_RS19010	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JVE63_RS19010	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JVE63_RS19045	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JVE63_RS19050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JVE63_RS19060	COG0513	Belongs to the DEAD box helicase family
JVE63_RS19185	COG4941	Belongs to the sigma-70 factor family
JVE63_RS19205	COG0741	lytic transglycosylase activity
JVE63_RS19205	COG1196	nuclear chromosome segregation
JVE63_RS19205	COG0739	heme binding
JVE63_RS19215	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JVE63_RS19220	COG0579	oxidoreductase
JVE63_RS19250	COG4585	Histidine kinase
JVE63_RS19255	COG2197	response regulator
JVE63_RS19285	COG1252	NADH dehydrogenase
JVE63_RS19290	COG2172	sigma factor antagonist activity
JVE63_RS19290	COG2208	phosphoserine phosphatase activity
JVE63_RS19290	COG1366	Belongs to the anti-sigma-factor antagonist family
JVE63_RS19300	COG1846	Transcriptional regulator
JVE63_RS19320	COG2197	response regulator
JVE63_RS19325	COG4585	Histidine kinase
JVE63_RS19335	COG1131	(ABC) transporter
JVE63_RS19370	COG0741	lytic transglycosylase activity
JVE63_RS19370	COG1196	nuclear chromosome segregation
JVE63_RS19370	COG0739	heme binding
JVE63_RS19375	COG0671	phosphoesterase, PA-phosphatase related
JVE63_RS19385	COG0277	FAD linked oxidase domain protein
JVE63_RS19405	COG1937	Protein conserved in bacteria
JVE63_RS19415	COG0306	phosphate transporter
JVE63_RS19425	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JVE63_RS19445	COG0494	nUDIX hydrolase
JVE63_RS19445	COG0406	alpha-ribazole phosphatase activity
JVE63_RS19455	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JVE63_RS19460	COG0456	acetyltransferase
JVE63_RS19480	COG0737	Belongs to the 5'-nucleotidase family
JVE63_RS19495	COG0745	RESPONSE REGULATOR receiver
JVE63_RS19500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JVE63_RS19510	COG0326	Molecular chaperone. Has ATPase activity
JVE63_RS19545	COG0179	Fumarylacetoacetate (FAA) hydrolase
JVE63_RS19570	COG1609	Transcriptional regulator
JVE63_RS19575	COG0745	RESPONSE REGULATOR receiver
JVE63_RS19600	COG1309	transcriptional regulator
JVE63_RS19605	COG2897	thiosulfate sulfurtransferase activity
JVE63_RS19640	COG3485	protocatechuate 3,4-dioxygenase
JVE63_RS19650	COG0354	folic acid binding
JVE63_RS19655	COG1490	D-aminoacyl-tRNA deacylase activity
JVE63_RS19670	COG4552	Acetyltransferase involved in intracellular survival and related
JVE63_RS19675	COG1309	transcriptional regulator
JVE63_RS19710	COG0346	lactoylglutathione lyase activity
JVE63_RS19740	COG2267	carboxylic ester hydrolase activity
JVE63_RS19795	COG0438	transferase activity, transferring glycosyl groups
JVE63_RS19870	COG0588	phosphoglycerate mutase activity
JVE63_RS19875	COG2211	Major facilitator Superfamily
JVE63_RS19890	COG5002	protein histidine kinase activity
JVE63_RS19905	COG1329	Transcriptional regulator
JVE63_RS19910	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JVE63_RS19915	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JVE63_RS19920	COG3467	pyridoxamine 5'-phosphate
JVE63_RS19925	COG0215	cysteine-tRNA ligase activity
JVE63_RS19930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JVE63_RS19950	COG4499	WXG100 protein secretion system (Wss), protein YukC
JVE63_RS19950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JVE63_RS19980	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JVE63_RS19990	COG1509	lysine 2,3-aminomutase activity
JVE63_RS19995	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JVE63_RS20025	COG1028	Short-chain dehydrogenase reductase Sdr
JVE63_RS20030	COG0488	(ABC) transporter
JVE63_RS20140	COG3842	ATPase activity
JVE63_RS20150	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JVE63_RS20155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JVE63_RS20220	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JVE63_RS20225	COG2197	response regulator
JVE63_RS20255	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
JVE63_RS20280	COG0191	fructose-bisphosphate aldolase activity
JVE63_RS20285	COG1105	Belongs to the carbohydrate kinase PfkB family
JVE63_RS20305	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JVE63_RS20345	COG1605	Chorismate mutase
JVE63_RS20405	COG0463	Glycosyl transferase, family 2
JVE63_RS20415	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
JVE63_RS20420	COG1877	trehalose-phosphatase activity
JVE63_RS20420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JVE63_RS20435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JVE63_RS20515	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
JVE63_RS20520	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JVE63_RS20580	COG3973	AAA domain
JVE63_RS20595	COG1061	Type III restriction enzyme res subunit
JVE63_RS20620	COG1278	Cold shock
JVE63_RS20625	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
JVE63_RS20630	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JVE63_RS20640	COG2814	Major facilitator Superfamily
JVE63_RS20660	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JVE63_RS20670	COG2252	PERMEase
JVE63_RS20685	COG0513	Belongs to the DEAD box helicase family
JVE63_RS20695	COG1846	Transcriptional regulator
JVE63_RS20710	COG0667	Aldo Keto reductase
JVE63_RS20715	COG0463	Glycosyl transferase, family 2
JVE63_RS20755	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
JVE63_RS20765	COG0277	FAD linked oxidase domain protein
JVE63_RS20765	COG0247	lactate metabolic process
JVE63_RS20770	COG0583	DNA-binding transcription factor activity
JVE63_RS20775	COG5006	permease, DMT superfamily
JVE63_RS20795	COG0259	pyridoxamine-phosphate oxidase activity
JVE63_RS20800	COG4821	SIS domain
JVE63_RS20810	COG2945	thiolester hydrolase activity
JVE63_RS20810	COG0596	Alpha beta hydrolase
JVE63_RS20920	COG0318	PFAM AMP-dependent synthetase and ligase
JVE63_RS20925	COG1960	acyl-CoA dehydrogenase activity
JVE63_RS20930	COG1960	acyl-CoA dehydrogenase activity
JVE63_RS20945	COG1028	Short-chain dehydrogenase reductase Sdr
JVE63_RS20950	COG1960	acyl-CoA dehydrogenase activity
JVE63_RS21005	COG2271	Major facilitator Superfamily
JVE63_RS21050	COG1024	Enoyl-CoA hydratase
JVE63_RS21065	COG2072	flavoprotein involved in K transport
JVE63_RS21095	COG1960	acyl-CoA dehydrogenase activity
JVE63_RS21110	COG3173	Aminoglycoside phosphotransferase
JVE63_RS21125	COG1309	transcriptional regulator
JVE63_RS21140	COG1024	Enoyl-CoA hydratase
JVE63_RS21200	COG0726	polysaccharide deacetylase
JVE63_RS21275	COG1028	Short-chain dehydrogenase reductase Sdr
JVE63_RS21290	COG0142	geranyltranstransferase activity
JVE63_RS21320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JVE63_RS21355	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JVE63_RS21460	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
JVE63_RS21485	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
JVE63_RS21515	COG1028	Short-chain dehydrogenase reductase Sdr
JVE63_RS21540	COG1686	Belongs to the peptidase S11 family
JVE63_RS21610	COG0709	Synthesizes selenophosphate from selenide and ATP
JVE63_RS21620	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JVE63_RS21625	COG1674	ftsk spoiiie
JVE63_RS21660	COG0318	PFAM AMP-dependent synthetase and ligase
JVE63_RS21685	COG3384	dioxygenase
JVE63_RS21710	COG0477	Major facilitator Superfamily
JVE63_RS21735	COG0243	molybdopterin cofactor binding
JVE63_RS21760	COG1970	mechanosensitive ion channel activity
JVE63_RS21770	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
JVE63_RS21795	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JVE63_RS21800	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JVE63_RS21810	COG0315	cyclic pyranopterin monophosphate synthase activity
JVE63_RS21815	COG0521	Mo-molybdopterin cofactor biosynthetic process
JVE63_RS21845	COG0583	DNA-binding transcription factor activity
JVE63_RS21865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JVE63_RS21875	COG1309	transcriptional regulator
JVE63_RS21885	COG0789	Transcriptional regulator
JVE63_RS21910	COG1136	(ABC) transporter
JVE63_RS21910	COG0577	efflux transmembrane transporter activity
JVE63_RS21945	COG0789	Transcriptional regulator
JVE63_RS21950	COG2072	flavoprotein involved in K transport
JVE63_RS21960	COG1028	Short-chain dehydrogenase reductase Sdr
JVE63_RS21970	COG0793	Belongs to the peptidase S41A family
JVE63_RS21970	COG4946	Tricorn protease homolog
JVE63_RS21985	COG2409	Drug exporters of the RND superfamily
JVE63_RS21995	COG0310	cobalt ion transport
JVE63_RS22005	COG1122	ATPase activity
JVE63_RS22010	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JVE63_RS22030	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
JVE63_RS22045	COG1131	(ABC) transporter
JVE63_RS22055	COG0442	prolyl-tRNA aminoacylation
JVE63_RS22060	COG0768	penicillin binding
JVE63_RS22080	COG0084	hydrolase, TatD family'
JVE63_RS22100	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JVE63_RS22105	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JVE63_RS22120	COG0488	(ABC) transporter
JVE63_RS22145	COG2197	response regulator
JVE63_RS22150	COG1846	Transcriptional regulator
JVE63_RS22155	COG4106	trans-aconitate 2-methyltransferase activity
JVE63_RS22170	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
JVE63_RS22185	COG0193	aminoacyl-tRNA hydrolase activity
JVE63_RS22190	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JVE63_RS22195	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JVE63_RS22200	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JVE63_RS22210	COG4585	Histidine kinase
JVE63_RS22240	COG1136	(ABC) transporter
JVE63_RS22245	COG0577	efflux transmembrane transporter activity
JVE63_RS22355	COG2124	cytochrome p450
JVE63_RS22370	COG0148	phosphopyruvate hydratase activity
JVE63_RS22390	COG1252	NADH dehydrogenase
JVE63_RS22395	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JVE63_RS22400	COG1136	(ABC) transporter
JVE63_RS22400	COG0577	efflux transmembrane transporter activity
JVE63_RS22405	COG1136	(ABC) transporter
JVE63_RS22435	COG0183	Belongs to the thiolase family
JVE63_RS22440	COG2755	lipolytic protein G-D-S-L family
JVE63_RS22480	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JVE63_RS22495	COG1228	amidohydrolase
JVE63_RS22525	COG0702	epimerase
JVE63_RS22545	COG0640	Transcriptional regulator
JVE63_RS22550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JVE63_RS22570	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JVE63_RS22650	COG1191	sigma factor activity
JVE63_RS22655	COG1366	Belongs to the anti-sigma-factor antagonist family
JVE63_RS22665	COG0596	Alpha beta hydrolase
JVE63_RS22675	COG1051	belongs to the nudix hydrolase family
JVE63_RS22745	COG1022	Amp-dependent synthetase and ligase
JVE63_RS22790	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JVE63_RS22790	COG1017	nitric oxide dioxygenase activity
JVE63_RS22795	COG1233	COG1233 Phytoene dehydrogenase and related
JVE63_RS22820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JVE63_RS22830	COG2030	dehydratase
JVE63_RS22855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JVE63_RS22860	COG1028	Short-chain dehydrogenase reductase Sdr
JVE63_RS22875	COG3104	oligopeptide transport
JVE63_RS22880	COG0745	RESPONSE REGULATOR receiver
JVE63_RS22885	COG2205	protein histidine kinase activity
JVE63_RS22920	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
JVE63_RS22940	COG1316	TRANSCRIPTIONal
JVE63_RS22945	COG1607	acyl-coa hydrolase
JVE63_RS22960	COG1316	TRANSCRIPTIONal
JVE63_RS22965	COG1316	TRANSCRIPTIONal
JVE63_RS22985	COG0778	Nitroreductase
JVE63_RS22985	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
JVE63_RS22990	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JVE63_RS23030	COG2835	tetraacyldisaccharide 4'-kinase activity
JVE63_RS23040	COG1482	cell wall glycoprotein biosynthetic process
JVE63_RS23050	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
JVE63_RS23090	COG0714	Associated with various cellular activities
JVE63_RS23110	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
JVE63_RS23115	COG0745	RESPONSE REGULATOR receiver
JVE63_RS23120	COG5002	protein histidine kinase activity
JVE63_RS23120	COG5000	phosphorelay sensor kinase activity
JVE63_RS23125	COG0823	Involved in the tonB-independent uptake of proteins
JVE63_RS23135	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JVE63_RS23140	COG2197	response regulator
JVE63_RS23145	COG3214	Protein conserved in bacteria
JVE63_RS23170	COG0693	protein deglycase activity
JVE63_RS23200	COG0395	ABC-type sugar transport system, permease component
JVE63_RS23205	COG1175	transmembrane transport
JVE63_RS23210	COG1653	transport
JVE63_RS23220	COG0515	serine threonine protein kinase
JVE63_RS23225	COG0515	serine threonine protein kinase
JVE63_RS23230	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
JVE63_RS23250	COG2884	Cell division ATP-binding protein ftsE
JVE63_RS23260	COG3409	Peptidoglycan-binding domain 1 protein
JVE63_RS23260	COG0793	Belongs to the peptidase S41A family
JVE63_RS23265	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JVE63_RS23280	COG0583	DNA-binding transcription factor activity
JVE63_RS23305	COG3973	AAA domain
JVE63_RS23305	COG3973	AAA domain
JVE63_RS23315	COG0776	regulation of translation
JVE63_RS23320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JVE63_RS23325	COG1678	Uncharacterized ACR, COG1678
JVE63_RS23340	COG1175	transmembrane transport
JVE63_RS23345	COG0395	ABC-type sugar transport system, permease component
JVE63_RS23350	COG3525	Glycosyl hydrolase, family 20, catalytic domain
JVE63_RS23365	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JVE63_RS23370	COG0529	Catalyzes the synthesis of activated sulfate
JVE63_RS23455	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JVE63_RS23470	COG3480	Lon protease (S16) C-terminal proteolytic domain
JVE63_RS23480	COG3185	4-Hydroxyphenylpyruvate dioxygenase
JVE63_RS23485	COG0745	RESPONSE REGULATOR receiver
JVE63_RS23490	COG2205	protein histidine kinase activity
JVE63_RS23510	COG0277	FAD linked oxidase domain protein
JVE63_RS23515	COG0702	epimerase
JVE63_RS23535	COG3209	COG3209 Rhs family protein
JVE63_RS23570	COG1335	isochorismatase
JVE63_RS23580	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JVE63_RS23595	COG1113	amino acid transport
JVE63_RS23605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JVE63_RS23610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JVE63_RS23615	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
JVE63_RS23630	COG4106	trans-aconitate 2-methyltransferase activity
JVE63_RS23695	COG1234	tRNA 3'-trailer cleavage
JVE63_RS23700	COG1263	PTS System
JVE63_RS23705	COG1263	PTS System
JVE63_RS23710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JVE63_RS23715	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JVE63_RS23725	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JVE63_RS23745	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JVE63_RS23755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JVE63_RS23770	COG4555	ABC transporter
JVE63_RS23780	COG2733	membrane
JVE63_RS23800	COG3764	Sortase (surface protein transpeptidase)
JVE63_RS23810	COG0706	membrane insertase activity
JVE63_RS23820	COG4702	Belongs to the UPF0303 family
JVE63_RS23825	COG0673	inositol 2-dehydrogenase activity
JVE63_RS23865	COG3397	chitin binding
JVE63_RS23885	COG1126	abc transporter atp-binding protein
JVE63_RS23890	COG0765	amino acid transport
JVE63_RS23895	COG0765	amino acid transport
JVE63_RS23905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JVE63_RS23915	COG5001	Diguanylate cyclase
JVE63_RS23915	COG3300	MHYT domain
JVE63_RS23940	COG0406	alpha-ribazole phosphatase activity
JVE63_RS23985	COG0745	RESPONSE REGULATOR receiver
JVE63_RS24000	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
JVE63_RS24005	COG4977	sequence-specific DNA binding
JVE63_RS24015	COG0589	response to stress
JVE63_RS24020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JVE63_RS24050	COG3486	L-lysine 6-monooxygenase (NADPH) activity
JVE63_RS24065	COG1960	acyl-CoA dehydrogenase activity
JVE63_RS24080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JVE63_RS24085	COG1309	transcriptional regulator
JVE63_RS24100	COG1946	Acyl-CoA thioesterase
JVE63_RS24115	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JVE63_RS24125	COG0028	Belongs to the TPP enzyme family
JVE63_RS24155	COG1472	Belongs to the glycosyl hydrolase 3 family
JVE63_RS24175	COG1846	Transcriptional regulator
JVE63_RS24175	COG0456	acetyltransferase
JVE63_RS24180	COG1609	Transcriptional regulator
JVE63_RS24185	COG0673	inositol 2-dehydrogenase activity
JVE63_RS24200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JVE63_RS24215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JVE63_RS24240	COG3718	enzyme involved in inositol metabolism
JVE63_RS24245	COG3962	Belongs to the TPP enzyme family
JVE63_RS24285	COG2267	carboxylic ester hydrolase activity
JVE63_RS24295	COG2205	protein histidine kinase activity
JVE63_RS24310	COG0659	secondary active sulfate transmembrane transporter activity
JVE63_RS24330	COG2197	response regulator
JVE63_RS24340	COG1136	(ABC) transporter
JVE63_RS24365	COG2205	protein histidine kinase activity
JVE63_RS24405	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JVE63_RS24410	COG0629	single-stranded DNA binding
JVE63_RS24445	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JVE63_RS24475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JVE63_RS24490	COG1486	melibiose metabolic process
JVE63_RS24495	COG0395	ABC-type sugar transport system, permease component
JVE63_RS24500	COG1175	transmembrane transport
JVE63_RS24515	COG0668	transmembrane transport
JVE63_RS24525	COG3291	Pkd domain containing protein
JVE63_RS24525	COG3525	Glycosyl hydrolase, family 20, catalytic domain
JVE63_RS24540	COG1846	Transcriptional regulator
JVE63_RS24545	COG0697	spore germination
JVE63_RS24615	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JVE63_RS24620	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JVE63_RS24630	COG1113	amino acid transport
JVE63_RS24650	COG4552	Acetyltransferase involved in intracellular survival and related
JVE63_RS24670	COG4941	Belongs to the sigma-70 factor family
JVE63_RS24680	COG0475	glutathione-regulated potassium exporter activity
JVE63_RS24700	COG0544	peptidyl-prolyl cis-trans isomerase activity
JVE63_RS24705	COG0740	serine-type endopeptidase activity
JVE63_RS24710	COG0740	serine-type endopeptidase activity
JVE63_RS24715	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JVE63_RS24725	COG0525	valine-tRNA ligase activity
JVE63_RS24730	COG4585	Histidine kinase
JVE63_RS24735	COG0285	dihydrofolate synthase activity
JVE63_RS24745	COG0105	UTP biosynthetic process
JVE63_RS24750	COG1077	Cell shape determining protein MreB Mrl
JVE63_RS24770	COG0772	Belongs to the SEDS family
JVE63_RS24795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JVE63_RS24800	COG0673	inositol 2-dehydrogenase activity
JVE63_RS24825	COG0438	transferase activity, transferring glycosyl groups
JVE63_RS24830	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
JVE63_RS24840	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JVE63_RS24845	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JVE63_RS24850	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JVE63_RS24855	COG0438	transferase activity, transferring glycosyl groups
JVE63_RS24870	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JVE63_RS24880	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JVE63_RS24895	COG0501	Belongs to the peptidase M48B family
JVE63_RS24905	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JVE63_RS24915	COG0799	negative regulation of ribosome biogenesis
JVE63_RS24920	COG0588	phosphoglycerate mutase activity
JVE63_RS24935	COG0477	Major facilitator Superfamily
JVE63_RS24965	COG0495	leucyl-tRNA aminoacylation
JVE63_RS24975	COG1307	EDD domain protein, DegV family
JVE63_RS24980	COG1555	photosystem II stabilization
JVE63_RS24980	COG1596	polysaccharide export
JVE63_RS24990	COG2162	N-hydroxyarylamine O-acetyltransferase activity
JVE63_RS25005	COG0268	Binds directly to 16S ribosomal RNA
JVE63_RS25010	COG0481	GTPase activity
JVE63_RS25035	COG1420	regulation of RNA biosynthetic process
JVE63_RS25040	COG0484	heat shock protein binding
JVE63_RS25060	COG0537	adenosine 5'-monophosphoramidase activity
JVE63_RS25065	COG1234	tRNA 3'-trailer cleavage
JVE63_RS25070	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JVE63_RS25085	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JVE63_RS25095	COG2315	Protein conserved in bacteria
JVE63_RS25120	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JVE63_RS25135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JVE63_RS25145	COG1381	Involved in DNA repair and RecF pathway recombination
JVE63_RS25150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JVE63_RS25165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JVE63_RS25170	COG1121	(ABC) transporter
JVE63_RS25175	COG3443	Belongs to the bacterial solute-binding protein 9 family
JVE63_RS25175	COG0803	Belongs to the bacterial solute-binding protein 9 family
JVE63_RS25180	COG0423	glycine-tRNA ligase activity
JVE63_RS25200	COG0574	Belongs to the PEP-utilizing enzyme family
JVE63_RS25200	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JVE63_RS25210	COG0531	amino acid
JVE63_RS25220	COG2890	protein-(glutamine-N5) methyltransferase activity
JVE63_RS25250	COG2949	membrane
JVE63_RS25255	COG0232	Belongs to the dGTPase family. Type 2 subfamily
JVE63_RS25265	COG0358	DNA primase activity
JVE63_RS25270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JVE63_RS25285	COG1070	Carbohydrate kinase
JVE63_RS25315	COG0142	geranyltranstransferase activity
JVE63_RS25320	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JVE63_RS25355	COG3585	molybdate ion transport
JVE63_RS25375	COG0318	PFAM AMP-dependent synthetase and ligase
JVE63_RS25390	COG1522	sequence-specific DNA binding
JVE63_RS25405	COG1077	Cell shape determining protein MreB Mrl
JVE63_RS25425	COG2130	NADP-dependent
JVE63_RS25430	COG1764	response to oxidative stress
JVE63_RS25465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JVE63_RS25470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JVE63_RS25475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JVE63_RS25500	COG0789	Transcriptional regulator
JVE63_RS25505	COG0667	Aldo Keto reductase
JVE63_RS25530	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JVE63_RS25535	COG2197	response regulator
JVE63_RS25540	COG4585	Histidine kinase
JVE63_RS25550	COG1309	transcriptional regulator
JVE63_RS25555	COG0477	Major facilitator Superfamily
JVE63_RS25565	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
JVE63_RS25610	COG1358	cellular component organization or biogenesis
JVE63_RS25620	COG0586	Pfam SNARE associated Golgi protein
JVE63_RS25720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JVE63_RS25735	COG4122	O-methyltransferase activity
JVE63_RS25745	COG2124	cytochrome p450
JVE63_RS25750	COG0183	Belongs to the thiolase family
JVE63_RS25760	COG3903	Transcriptional regulator
JVE63_RS25760	COG3629	intracellular signal transduction
JVE63_RS25780	COG3845	ABC transporter
JVE63_RS25820	COG1309	transcriptional regulator
JVE63_RS25840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JVE63_RS25860	COG1960	acyl-CoA dehydrogenase activity
JVE63_RS25865	COG0183	Belongs to the thiolase family
JVE63_RS25880	COG2030	dehydratase
JVE63_RS25890	COG1028	Short-chain dehydrogenase reductase Sdr
JVE63_RS25905	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JVE63_RS25920	COG0800	Aldolase
JVE63_RS25925	COG3022	response to hydroperoxide
JVE63_RS25950	COG4249	Peptidase C14 caspase catalytic subunit p20
JVE63_RS25950	COG2319	Wd-40 repeat
JVE63_RS25965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JVE63_RS25975	COG1595	DNA-templated transcription, initiation
JVE63_RS26000	COG3540	Alkaline phosphatase
JVE63_RS26005	COG2814	Major facilitator Superfamily
JVE63_RS26015	COG1834	amidinotransferase
JVE63_RS26035	COG0672	)-iron permease
JVE63_RS26045	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
JVE63_RS26050	COG0583	DNA-binding transcription factor activity
JVE63_RS26055	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JVE63_RS26120	COG1120	ATPase activity
JVE63_RS26125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JVE63_RS26130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JVE63_RS26150	COG5398	heme oxygenase
JVE63_RS26220	COG1994	Peptidase M50
JVE63_RS26240	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JVE63_RS26255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JVE63_RS26255	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JVE63_RS26260	COG2132	Multicopper oxidase
JVE63_RS26275	COG2267	carboxylic ester hydrolase activity
JVE63_RS26300	COG0174	glutamine synthetase
JVE63_RS26305	COG2197	response regulator
JVE63_RS26310	COG4585	Histidine kinase
JVE63_RS26340	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
JVE63_RS26380	COG0477	Major facilitator Superfamily
JVE63_RS26390	COG1609	Transcriptional regulator
JVE63_RS26395	COG0366	Alpha amylase catalytic
JVE63_RS26400	COG3833	ABC-type maltose transport systems, permease component
JVE63_RS26410	COG2182	Extracellular solute-binding protein
JVE63_RS26440	COG2197	response regulator
JVE63_RS26445	COG4585	Histidine kinase
JVE63_RS26470	COG0745	RESPONSE REGULATOR receiver
JVE63_RS26505	COG0181	hydroxymethylbilane synthase activity
JVE63_RS26535	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JVE63_RS26540	COG0321	lipoyl(octanoyl) transferase activity
JVE63_RS26570	COG1028	Short-chain dehydrogenase reductase Sdr
JVE63_RS26585	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
JVE63_RS26600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JVE63_RS26605	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JVE63_RS26625	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
JVE63_RS26625	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JVE63_RS26630	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
JVE63_RS26645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JVE63_RS26650	COG1132	(ABC) transporter
JVE63_RS26675	COG4585	Histidine kinase
JVE63_RS26680	COG2197	response regulator
JVE63_RS26685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JVE63_RS26695	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
JVE63_RS26715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JVE63_RS26725	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JVE63_RS26730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JVE63_RS26740	COG1376	ErfK ybiS ycfS ynhG family protein
JVE63_RS26750	COG1845	cytochrome c oxidase, subunit III
JVE63_RS26755	COG2010	Cytochrome c
JVE63_RS26760	COG0723	plastoquinol--plastocyanin reductase activity
JVE63_RS26765	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JVE63_RS26770	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JVE63_RS26775	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JVE63_RS26780	COG1929	Belongs to the glycerate kinase type-1 family
JVE63_RS26790	COG0745	RESPONSE REGULATOR receiver
JVE63_RS26795	COG2205	protein histidine kinase activity
JVE63_RS26845	COG0438	transferase activity, transferring glycosyl groups
JVE63_RS26875	COG1940	carbohydrate kinase activity
JVE63_RS26900	COG4585	Histidine kinase
JVE63_RS26905	COG2197	response regulator
JVE63_RS26910	COG0205	6-phosphofructokinase activity
JVE63_RS26915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JVE63_RS26925	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
JVE63_RS26935	COG2193	ferroxidase activity
JVE63_RS26940	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JVE63_RS26945	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JVE63_RS26950	COG0515	serine threonine protein kinase
JVE63_RS26950	COG2815	serine threonine protein kinase
JVE63_RS26965	COG2022	thiamine diphosphate biosynthetic process
JVE63_RS26965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JVE63_RS26985	COG0352	thiamine-phosphate diphosphorylase activity
JVE63_RS27000	COG1233	COG1233 Phytoene dehydrogenase and related
JVE63_RS27005	COG1309	transcriptional regulator
JVE63_RS27015	COG1121	(ABC) transporter
JVE63_RS27045	COG0714	Associated with various cellular activities
JVE63_RS27055	COG0275	rRNA processing
JVE63_RS27070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JVE63_RS27080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JVE63_RS27085	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JVE63_RS27095	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JVE63_RS27100	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
JVE63_RS27105	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JVE63_RS27110	COG1496	oxidoreductase activity
JVE63_RS27120	COG1799	cell septum assembly
JVE63_RS27135	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JVE63_RS27145	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JVE63_RS27155	COG0025	NhaP-type Na H and K H
JVE63_RS27190	COG0587	DNA-directed DNA polymerase activity
JVE63_RS27220	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JVE63_RS27240	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JVE63_RS27245	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JVE63_RS27250	COG0131	Imidazoleglycerol-phosphate dehydratase
JVE63_RS27260	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JVE63_RS27265	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JVE63_RS27270	COG0107	imidazoleglycerol-phosphate synthase activity
JVE63_RS27280	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JVE63_RS27285	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JVE63_RS27305	COG0134	indole-3-glycerol-phosphate synthase activity
JVE63_RS27310	COG0133	tryptophan synthase activity
JVE63_RS27315	COG0159	tryptophan synthase activity
JVE63_RS27325	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JVE63_RS27335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JVE63_RS27340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JVE63_RS27370	COG0067	glutamate synthase
JVE63_RS27370	COG0070	glutamate synthase
JVE63_RS27370	COG0069	glutamate synthase activity
JVE63_RS27400	COG1960	acyl-CoA dehydrogenase activity
JVE63_RS27410	COG1309	transcriptional regulator
JVE63_RS27415	COG0183	Belongs to the thiolase family
JVE63_RS27445	COG1024	Enoyl-CoA hydratase
JVE63_RS27450	COG1028	Short-chain dehydrogenase reductase Sdr
JVE63_RS27455	COG1028	Short-chain dehydrogenase reductase Sdr
JVE63_RS27475	COG1605	Chorismate mutase
JVE63_RS27475	COG0287	Prephenate dehydrogenase
JVE63_RS27490	COG3486	L-lysine 6-monooxygenase (NADPH) activity
JVE63_RS27540	COG2050	protein possibly involved in aromatic compounds catabolism
JVE63_RS27570	COG1643	Atp-dependent helicase
JVE63_RS27580	COG0539	negative regulation of cytoplasmic translation
JVE63_RS27590	COG0237	dephospho-CoA kinase activity
JVE63_RS27610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JVE63_RS27630	COG2313	pseudouridylate synthase activity
JVE63_RS27635	COG0477	Major facilitator Superfamily
JVE63_RS27640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JVE63_RS27650	COG0556	nucleotide-excision repair
JVE63_RS27670	COG1136	(ABC) transporter
JVE63_RS27670	COG0577	efflux transmembrane transporter activity
JVE63_RS27675	COG1136	(ABC) transporter
JVE63_RS27675	COG0577	efflux transmembrane transporter activity
JVE63_RS27690	COG0745	RESPONSE REGULATOR receiver
JVE63_RS27695	COG2205	protein histidine kinase activity
JVE63_RS27710	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JVE63_RS27740	COG0322	excinuclease ABC activity
JVE63_RS27745	COG1660	Displays ATPase and GTPase activities
JVE63_RS27750	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JVE63_RS27755	COG1481	regulation of sporulation
JVE63_RS27765	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JVE63_RS27770	COG0126	phosphoglycerate kinase activity
JVE63_RS27775	COG0149	triose-phosphate isomerase activity
JVE63_RS27780	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JVE63_RS27790	COG0166	Belongs to the GPI family
JVE63_RS27800	COG4195	phage-related replication protein
JVE63_RS27805	COG0363	glucosamine-6-phosphate deaminase activity
JVE63_RS27820	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JVE63_RS27825	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JVE63_RS27830	COG0109	protoheme IX farnesyltransferase activity
JVE63_RS27840	COG1612	heme a metabolic process
JVE63_RS27865	COG0719	Fe-S assembly protein
JVE63_RS27875	COG0396	ATPase activity
JVE63_RS27880	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JVE63_RS27885	COG0822	iron-sulfur transferase activity
JVE63_RS27890	COG2151	metal-sulfur cluster biosynthetic enzyme
JVE63_RS27895	COG2076	Multidrug Resistance protein
JVE63_RS27900	COG3226	Transcriptional regulator
JVE63_RS27905	COG2171	N-acyltransferase activity
JVE63_RS27975	COG0768	penicillin binding
JVE63_RS27990	COG1846	Transcriptional regulator
JVE63_RS27995	COG1902	pentaerythritol trinitrate reductase activity
JVE63_RS28020	COG1104	cysteine desulfurase activity
JVE63_RS28060	COG0395	ABC-type sugar transport system, permease component
JVE63_RS28065	COG1175	transmembrane transport
JVE63_RS28090	COG2226	methyltransferase
JVE63_RS28130	COG1797	cobyrinic acid a,c-diamide synthase activity
JVE63_RS28145	COG1492	cobalamin metabolic process
JVE63_RS28150	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
JVE63_RS28165	COG0235	Class ii aldolase
JVE63_RS28180	COG0488	(ABC) transporter
JVE63_RS28230	COG3387	PFAM Glycoside hydrolase 15-related
JVE63_RS28245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JVE63_RS28275	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JVE63_RS28280	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JVE63_RS28300	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JVE63_RS28315	COG1028	Short-chain dehydrogenase reductase Sdr
JVE63_RS28320	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JVE63_RS28330	COG2186	Transcriptional regulator
JVE63_RS28335	COG2807	transmembrane transport
JVE63_RS28350	COG3830	Belongs to the UPF0237 family
JVE63_RS28350	COG0560	Phosphoserine phosphatase
JVE63_RS28360	COG1716	ATPase activity
JVE63_RS28360	COG1131	(ABC) transporter
JVE63_RS28360	COG0842	Transport permease protein
JVE63_RS28375	COG4585	Histidine kinase
JVE63_RS28380	COG2197	response regulator
JVE63_RS28400	COG1119	ATPase activity
JVE63_RS28425	COG1881	PFAM PEBP family protein
JVE63_RS28435	COG2094	Belongs to the DNA glycosylase MPG family
JVE63_RS28470	COG0647	UMP catabolic process
JVE63_RS28475	COG1120	ATPase activity
JVE63_RS28495	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JVE63_RS28505	COG0497	DNA recombination
JVE63_RS28515	COG0438	transferase activity, transferring glycosyl groups
JVE63_RS28525	COG3387	PFAM Glycoside hydrolase 15-related
JVE63_RS28530	COG0504	CTP synthase activity
JVE63_RS28535	COG0494	nUDIX hydrolase
JVE63_RS28545	COG0686	Belongs to the AlaDH PNT family
JVE63_RS28560	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JVE63_RS28565	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JVE63_RS28570	COG1187	pseudouridine synthase activity
JVE63_RS28575	COG0494	nUDIX hydrolase
JVE63_RS28585	COG3541	Predicted nucleotidyltransferase
JVE63_RS28595	COG0723	plastoquinol--plastocyanin reductase activity
JVE63_RS28610	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JVE63_RS28615	COG0204	Acyl-transferase
JVE63_RS28620	COG1160	GTP binding
JVE63_RS28635	COG0438	transferase activity, transferring glycosyl groups
JVE63_RS28650	COG0671	phosphoesterase, PA-phosphatase related
JVE63_RS28655	COG0477	Major facilitator Superfamily
JVE63_RS28660	COG1960	acyl-CoA dehydrogenase activity
JVE63_RS28665	COG1799	cell septum assembly
JVE63_RS28695	COG0641	radical SAM
JVE63_RS28710	COG3903	Transcriptional regulator
JVE63_RS28710	COG3629	intracellular signal transduction
JVE63_RS28740	COG4565	transcriptional regulatory protein
JVE63_RS28770	COG1725	Transcriptional regulator
JVE63_RS28780	COG0726	polysaccharide deacetylase
JVE63_RS28785	COG1216	Glycosyl transferase, family 2
JVE63_RS28800	COG2755	lipolytic protein G-D-S-L family
JVE63_RS28805	COG0515	serine threonine protein kinase
JVE63_RS28815	COG2188	Transcriptional regulator
JVE63_RS28820	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
JVE63_RS28830	COG2851	Citrate transporter
JVE63_RS28840	COG1960	acyl-CoA dehydrogenase activity
JVE63_RS28875	COG3876	Protein conserved in bacteria
JVE63_RS28880	COG1309	transcriptional regulator
JVE63_RS28900	COG2149	membrane
JVE63_RS28905	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
JVE63_RS28920	COG3265	gluconokinase activity
JVE63_RS28925	COG2186	Transcriptional regulator
JVE63_RS28930	COG1113	amino acid transport
JVE63_RS28945	COG0564	pseudouridine synthase activity
JVE63_RS28955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JVE63_RS28980	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
JVE63_RS28990	COG0667	Aldo Keto reductase
JVE63_RS28995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JVE63_RS29020	COG0215	cysteine-tRNA ligase activity
JVE63_RS29030	COG2186	Transcriptional regulator
JVE63_RS29035	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JVE63_RS29040	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JVE63_RS29045	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JVE63_RS29050	COG1414	Transcriptional regulator
JVE63_RS29055	COG0646	methionine synthase
JVE63_RS29055	COG1410	methionine synthase
JVE63_RS29070	COG2197	response regulator
JVE63_RS29080	COG0517	IMP dehydrogenase activity
JVE63_RS29080	COG1994	Peptidase M50
JVE63_RS29100	COG1222	aaa ATPase
JVE63_RS29105	COG4122	O-methyltransferase activity
JVE63_RS29115	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
JVE63_RS29130	COG1609	Transcriptional regulator
JVE63_RS29140	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
JVE63_RS29145	COG0545	Peptidyl-prolyl cis-trans isomerase
JVE63_RS29175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JVE63_RS29180	COG0805	protein transport
JVE63_RS29205	COG0346	lactoylglutathione lyase activity
JVE63_RS29210	COG2801	Transposase and inactivated derivatives
JVE63_RS29210	COG3415	Transposase
JVE63_RS29220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JVE63_RS29225	COG4175	Glycine betaine
JVE63_RS29225	COG0517	IMP dehydrogenase activity
JVE63_RS29230	COG4176	ABC-type proline glycine betaine transport system permease component
JVE63_RS29240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JVE63_RS29270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JVE63_RS29275	COG0444	Belongs to the ABC transporter superfamily
JVE63_RS29285	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JVE63_RS29295	COG2186	Transcriptional regulator
JVE63_RS29300	COG0174	glutamine synthetase
JVE63_RS29305	COG1012	belongs to the aldehyde dehydrogenase family
JVE63_RS29345	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JVE63_RS29350	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JVE63_RS29355	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JVE63_RS29360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JVE63_RS29365	COG5002	protein histidine kinase activity
JVE63_RS29370	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JVE63_RS29375	COG0072	phenylalanine-tRNA ligase activity
JVE63_RS29375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JVE63_RS29390	COG1051	belongs to the nudix hydrolase family
JVE63_RS29400	COG1649	PFAM Uncharacterised BCR, COG1649
JVE63_RS29410	COG0697	spore germination
JVE63_RS29450	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JVE63_RS29455	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
JVE63_RS29460	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JVE63_RS29465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JVE63_RS29470	COG1438	arginine binding
JVE63_RS29480	COG0137	argininosuccinate synthase activity
JVE63_RS29500	COG0477	Major facilitator Superfamily
JVE63_RS29505	COG0318	PFAM AMP-dependent synthetase and ligase
JVE63_RS29505	COG0204	Acyl-transferase
JVE63_RS29510	COG0584	glycerophosphoryl diester phosphodiesterase
JVE63_RS29535	COG2011	ABC-type metal ion transport system permease component
JVE63_RS29540	COG1464	Belongs to the NlpA lipoprotein family
JVE63_RS29560	COG1648	precorrin-2 dehydrogenase activity
JVE63_RS29560	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JVE63_RS29570	COG3973	AAA domain
JVE63_RS29625	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JVE63_RS29690	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JVE63_RS29705	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JVE63_RS29710	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JVE63_RS29730	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JVE63_RS29740	COG0438	transferase activity, transferring glycosyl groups
JVE63_RS29750	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
JVE63_RS29755	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
JVE63_RS29760	COG0217	transcriptional regulatory protein
JVE63_RS29765	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JVE63_RS29770	COG0632	four-way junction helicase activity
JVE63_RS29775	COG2255	four-way junction helicase activity
JVE63_RS29785	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JVE63_RS29790	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JVE63_RS29795	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JVE63_RS29800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JVE63_RS29805	COG1196	nuclear chromosome segregation
JVE63_RS29820	COG0124	histidyl-tRNA synthetase
JVE63_RS29840	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JVE63_RS29855	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JVE63_RS29860	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JVE63_RS29865	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JVE63_RS29870	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JVE63_RS29875	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JVE63_RS29880	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JVE63_RS29885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JVE63_RS29890	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JVE63_RS29900	COG0006	proline dipeptidase activity
JVE63_RS29905	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JVE63_RS29910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JVE63_RS29920	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
JVE63_RS29925	COG0540	Belongs to the ATCase OTCase family
JVE63_RS29930	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JVE63_RS29940	COG0505	Belongs to the CarA family
JVE63_RS29945	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JVE63_RS29950	COG0167	dihydroorotate dehydrogenase activity
JVE63_RS29955	COG0284	orotidine-5'-phosphate decarboxylase activity
JVE63_RS29965	COG0194	GDP metabolic process
JVE63_RS29980	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JVE63_RS29985	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JVE63_RS29995	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JVE63_RS30005	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JVE63_RS30010	COG2390	Transcriptional regulator
JVE63_RS30015	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
JVE63_RS30030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JVE63_RS30040	COG1309	transcriptional regulator
JVE63_RS30045	COG1028	Short-chain dehydrogenase reductase Sdr
JVE63_RS30060	COG0738	Major facilitator superfamily
JVE63_RS30065	COG1940	carbohydrate kinase activity
JVE63_RS30065	COG1846	Transcriptional regulator
JVE63_RS30080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JVE63_RS30095	COG3201	nicotinamide mononucleotide transporter
JVE63_RS30100	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JVE63_RS30100	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JVE63_RS30105	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JVE63_RS30110	COG0140	phosphoribosyl-ATP diphosphatase activity
JVE63_RS30115	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JVE63_RS30135	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JVE63_RS30145	COG0582	viral genome integration into host DNA
JVE63_RS30150	COG2124	cytochrome p450
JVE63_RS30160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JVE63_RS30170	COG0142	geranyltranstransferase activity
JVE63_RS30190	COG1960	acyl-CoA dehydrogenase activity
JVE63_RS30210	COG0463	Glycosyl transferase, family 2
JVE63_RS30215	COG3030	protein affecting phage T7 exclusion by the F plasmid
JVE63_RS30220	COG4249	Peptidase C14 caspase catalytic subunit p20
JVE63_RS30220	COG2319	Wd-40 repeat
JVE63_RS30220	COG2319	Wd-40 repeat
JVE63_RS30220	COG4249	Peptidase C14 caspase catalytic subunit p20
JVE63_RS30250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JVE63_RS30280	COG1984	allophanate hydrolase subunit 2
JVE63_RS30285	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JVE63_RS30290	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JVE63_RS30320	COG2018	Roadblock/LC7 domain
JVE63_RS30355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JVE63_RS30365	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JVE63_RS30395	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
JVE63_RS30415	COG1716	ATPase activity
JVE63_RS30435	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JVE63_RS30445	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JVE63_RS30445	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JVE63_RS30470	COG0384	phenazine biosynthesis protein PhzF
JVE63_RS30520	COG0583	DNA-binding transcription factor activity
JVE63_RS30550	COG2226	methyltransferase
JVE63_RS30590	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JVE63_RS30625	COG2813	Specifically methylates the guanine in position
JVE63_RS30635	COG1968	undecaprenyl-diphosphatase activity
JVE63_RS30645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JVE63_RS30710	COG1832	CoA-binding protein
JVE63_RS30715	COG1739	Uncharacterized protein family UPF0029
JVE63_RS30720	COG0420	3'-5' exonuclease activity
JVE63_RS30725	COG0419	ATPase involved in DNA repair
JVE63_RS30730	COG1522	sequence-specific DNA binding
JVE63_RS30740	COG1028	Short-chain dehydrogenase reductase Sdr
JVE63_RS30765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JVE63_RS30790	COG2188	Transcriptional regulator
JVE63_RS30805	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JVE63_RS30835	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
JVE63_RS30840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JVE63_RS30870	COG0740	serine-type endopeptidase activity
JVE63_RS30900	COG0204	Acyl-transferase
JVE63_RS30915	COG0205	6-phosphofructokinase activity
JVE63_RS30920	COG3442	glutamine amidotransferase
JVE63_RS30930	COG0242	peptide deformylase activity
JVE63_RS30940	COG1960	acyl-CoA dehydrogenase activity
JVE63_RS30945	COG0386	Belongs to the glutathione peroxidase family
JVE63_RS30950	COG1946	Acyl-CoA thioesterase
JVE63_RS30970	COG1132	(ABC) transporter
JVE63_RS30975	COG1132	(ABC) transporter
JVE63_RS30980	COG0673	inositol 2-dehydrogenase activity
JVE63_RS30990	COG1132	(ABC) transporter
JVE63_RS30995	COG2072	flavoprotein involved in K transport
JVE63_RS31000	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JVE63_RS31015	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JVE63_RS31015	COG0515	serine threonine protein kinase
JVE63_RS31030	COG1309	transcriptional regulator
JVE63_RS31070	COG4245	von Willebrand factor, type A
JVE63_RS31095	COG0542	response to heat
JVE63_RS31105	COG1100	Small GTP-binding protein
JVE63_RS31120	COG1404	Belongs to the peptidase S8 family
JVE63_RS31125	COG1278	Cold shock
JVE63_RS31140	COG3959	Transketolase, thiamine diphosphate binding domain
JVE63_RS31175	COG3424	synthase
JVE63_RS31185	COG3284	Transcriptional regulator
JVE63_RS31210	COG4829	muconolactone delta-isomerase
JVE63_RS31215	COG3485	protocatechuate 3,4-dioxygenase
JVE63_RS31220	COG4948	Mandelate Racemase Muconate Lactonizing
JVE63_RS31225	COG0583	DNA-binding transcription factor activity
JVE63_RS31245	COG1028	Short-chain dehydrogenase reductase Sdr
JVE63_RS31290	COG0017	Asparaginyl-tRNA synthetase
JVE63_RS31310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JVE63_RS31315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JVE63_RS31315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JVE63_RS31320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JVE63_RS31335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JVE63_RS31350	COG3629	intracellular signal transduction
JVE63_RS31350	COG3903	Transcriptional regulator
JVE63_RS31360	COG0577	efflux transmembrane transporter activity
JVE63_RS31360	COG1136	(ABC) transporter
JVE63_RS31365	COG0577	efflux transmembrane transporter activity
JVE63_RS31365	COG1136	(ABC) transporter
JVE63_RS31380	COG0745	RESPONSE REGULATOR receiver
JVE63_RS31385	COG2205	protein histidine kinase activity
JVE63_RS31395	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JVE63_RS31410	COG0714	Associated with various cellular activities
JVE63_RS31420	COG4941	Belongs to the sigma-70 factor family
JVE63_RS31425	COG3795	YCII-related domain
JVE63_RS31485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JVE63_RS31495	COG1120	ATPase activity
JVE63_RS31525	COG1132	(ABC) transporter
JVE63_RS31530	COG1132	(ABC) transporter
JVE63_RS31550	COG1404	Belongs to the peptidase S8 family
JVE63_RS31550	COG4412	M6 family metalloprotease domain protein
JVE63_RS31560	COG1131	(ABC) transporter
JVE63_RS31570	COG0309	Hydrogenase expression formation protein (HypE)
JVE63_RS31585	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
JVE63_RS31590	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
JVE63_RS31595	COG0375	protein maturation
JVE63_RS31640	COG2326	polyphosphate kinase activity
JVE63_RS31735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JVE63_RS31755	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JVE63_RS31780	COG1309	transcriptional regulator
JVE63_RS31785	COG0671	phosphoesterase, PA-phosphatase related
JVE63_RS31805	COG0584	glycerophosphoryl diester phosphodiesterase
JVE63_RS31835	COG0204	Acyl-transferase
JVE63_RS31845	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
JVE63_RS31880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JVE63_RS31890	COG0644	oxidoreductase
JVE63_RS31905	COG4585	Histidine kinase
JVE63_RS31910	COG2197	response regulator
JVE63_RS31920	COG1940	carbohydrate kinase activity
JVE63_RS31975	COG0463	Glycosyl transferase, family 2
JVE63_RS31980	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JVE63_RS32065	COG0515	serine threonine protein kinase
JVE63_RS32065	COG2815	serine threonine protein kinase
JVE63_RS32075	COG1131	(ABC) transporter
JVE63_RS32075	COG0842	Transport permease protein
JVE63_RS32075	COG1716	ATPase activity
JVE63_RS32080	COG1486	melibiose metabolic process
JVE63_RS32135	COG0363	glucosamine-6-phosphate deaminase activity
JVE63_RS32160	COG1461	Dihydroxyacetone kinase
JVE63_RS32165	COG2376	Dihydroxyacetone kinase
JVE63_RS32170	COG1181	Belongs to the D-alanine--D-alanine ligase family
JVE63_RS32175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JVE63_RS32225	COG0604	alcohol dehydrogenase
JVE63_RS32225	COG3321	synthase
JVE63_RS32255	COG2423	ornithine cyclodeaminase activity
JVE63_RS32260	COG1250	3-hydroxyacyl-CoA dehydrogenase
JVE63_RS32270	COG1960	acyl-CoA dehydrogenase activity
JVE63_RS32285	COG1028	Short-chain dehydrogenase reductase Sdr
JVE63_RS32290	COG1960	acyl-CoA dehydrogenase activity
JVE63_RS32305	COG0626	cystathionine gamma-synthase activity
JVE63_RS32325	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JVE63_RS32375	COG1120	ATPase activity
JVE63_RS32380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JVE63_RS32390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JVE63_RS32395	COG1535	isochorismatase
JVE63_RS32395	COG3433	isochorismatase activity
JVE63_RS32420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JVE63_RS32505	COG1674	ftsk spoiiie
JVE63_RS32525	COG4104	PAAR repeat-containing protein
JVE63_RS32525	COG3209	COG3209 Rhs family protein
JVE63_RS32545	COG0583	DNA-binding transcription factor activity
JVE63_RS32555	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
JVE63_RS32560	COG1126	abc transporter atp-binding protein
JVE63_RS32565	COG0765	amino acid transport
JVE63_RS32570	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
JVE63_RS32595	COG0604	alcohol dehydrogenase
JVE63_RS32595	COG3321	synthase
JVE63_RS32620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JVE63_RS32625	COG1309	transcriptional regulator
JVE63_RS32645	COG3321	synthase
JVE63_RS32645	COG0604	alcohol dehydrogenase
JVE63_RS32645	COG3321	synthase
JVE63_RS32645	COG0604	alcohol dehydrogenase
JVE63_RS32650	COG3321	synthase
JVE63_RS32650	COG0604	alcohol dehydrogenase
JVE63_RS32650	COG3321	synthase
JVE63_RS32650	COG0604	alcohol dehydrogenase
JVE63_RS32670	COG3321	synthase
JVE63_RS32670	COG0604	alcohol dehydrogenase
JVE63_RS32680	COG0508	dehydrogenase complex catalyzes the overall conversion of
JVE63_RS32685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JVE63_RS32695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JVE63_RS32705	COG0747	negative chemotaxis