locus-tag class description B7R87_RS00040 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone B7R87_RS00075 ENOG4106A3M Cytochrome p-450 B7R87_RS00095 ENOG4105CEY Amp-dependent synthetase and ligase B7R87_RS00130 ENOG4108VTW Thioesterase B7R87_RS00135 ENOG4105CEY Amp-dependent synthetase and ligase B7R87_RS00150 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase B7R87_RS00160 ENOG4105CEY Amp-dependent synthetase and ligase B7R87_RS00180 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) B7R87_RS00190 ENOG4105CIK Amidinotransferase B7R87_RS00235 ENOG41064MX Tetr family transcriptional regulator B7R87_RS00290 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein B7R87_RS00295 ENOG4107QSS Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli (By similarity) B7R87_RS00325 ENOG4105CJ1 ABC, transporter B7R87_RS00335 ENOG4105BZU Histidine kinase B7R87_RS00340 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) B7R87_RS00375 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) B7R87_RS00385 ENOG4108I0Q anthranilate phosphoribosyltransferase B7R87_RS00390 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) B7R87_RS00395 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) B7R87_RS00400 ENOG4105C1G acyl-Coa dehydrogenase B7R87_RS00410 ENOG4105DK0 Indole-3-glycerol phosphate synthase B7R87_RS00420 ENOG4107SM8 Adenylate Guanylate cyclase B7R87_RS00430 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) B7R87_RS00435 ENOG4105CHR reductase B7R87_RS00460 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS00470 ENOG4105C1G acyl-Coa dehydrogenase B7R87_RS00475 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) B7R87_RS00480 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase B7R87_RS00485 ENOG4107SQU synthase B7R87_RS00560 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) B7R87_RS00570 ENOG41067SE Tetr family transcriptional regulator B7R87_RS00600 ENOG4105CSH Transporter B7R87_RS00620 ENOG4108Q5F Tetr family transcriptional regulator B7R87_RS00630 ENOG4105D44 asparaginase B7R87_RS00650 ENOG4106A3M Cytochrome p-450 B7R87_RS00655 ENOG4105JZI cytochrome P450 B7R87_RS00680 ENOG4105D22 carbon starvation protein B7R87_RS00715 ENOG4105DBM Siderophore biosynthesis protein B7R87_RS00770 ENOG4105JQN Transcriptional regulator B7R87_RS00775 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) B7R87_RS00780 ENOG4105CPQ Dehydrogenase B7R87_RS00795 ENOG4105GWZ Roadblock lc7 family protein B7R87_RS00810 ENOG4105C0D helicase B7R87_RS00825 ENOG4107RR1 TRANSCRIPTIONal B7R87_RS00905 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) B7R87_RS00910 ENOG4105F44 Two component transcriptional regulator, winged helix family B7R87_RS00915 ENOG4106F60 Histidine kinase B7R87_RS00935 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) B7R87_RS00940 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) B7R87_RS00950 ENOG4105BZ1 (ABC) transporter B7R87_RS00955 ENOG4107RST alpha/beta hydrolase fold B7R87_RS00960 ENOG4105E8R UPF0173 metal-dependent hydrolase B7R87_RS00975 ENOG4105CEY Amp-dependent synthetase and ligase B7R87_RS00980 ENOG4106A3M Cytochrome p-450 B7R87_RS00985 ENOG4107RCI amp-dependent synthetase and ligase B7R87_RS00995 ENOG4108KPJ rna polymerase sigma factor B7R87_RS01025 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS01060 ENOG410880H cysteine synthase B7R87_RS01075 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) B7R87_RS01080 ENOG4105C3U ABC transporter B7R87_RS01085 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B7R87_RS01125 ENOG4107SMB hydrolase Family 5 B7R87_RS01130 ENOG4108IJ8 ABC transporter B7R87_RS01145 ENOG4105E90 ABC transporter B7R87_RS01150 ENOG4105E90 ABC transporter B7R87_RS01165 ENOG4107SQD Transcriptional regulator, GntR family B7R87_RS01170 ENOG4107QTZ amino acid B7R87_RS01180 ENOG4108M1A Chitin-binding protein B7R87_RS01190 ENOG4105MVE transcriptional regulator B7R87_RS01195 ENOG4105CVJ phosphoglycerate mutase B7R87_RS01200 ENOG4108JQ1 Dehydrogenase B7R87_RS01220 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin B7R87_RS01245 ENOG4108ZJ4 polysaccharide deacetylase B7R87_RS01265 ENOG41061TZ Short-chain dehydrogenase reductase Sdr B7R87_RS01275 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS01300 ENOG4105DEF Extracellular solute-binding protein, family 5 B7R87_RS01310 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B7R87_RS01320 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) B7R87_RS01325 ENOG4105C7S Dehydrogenase B7R87_RS01365 ENOG4108JA1 polyketide synthase B7R87_RS01365 ENOG4108JA1 polyketide synthase B7R87_RS01375 ENOG4107SCK Monooxygenase B7R87_RS01385 ENOG4105XEA Tetr family transcriptional regulator B7R87_RS01390 ENOG4105DEN Luciferase family B7R87_RS01430 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) B7R87_RS01435 ENOG4105EAD ABC transporter B7R87_RS01440 ENOG4105CDA abc transporter atp-binding protein B7R87_RS01455 ENOG4105C5Q Transcriptional regulator B7R87_RS01475 ENOG4105CNA YD repeat protein B7R87_RS01485 ENOG4106F1P AAA ATPase, central domain protein B7R87_RS01495 ENOG4105EC2 ftsk spoIIIe B7R87_RS01575 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) B7R87_RS01600 ENOG4105WQI isochorismatase B7R87_RS01605 ENOG4105CEY Amp-dependent synthetase and ligase B7R87_RS01615 ENOG4105EHG Permease protein B7R87_RS01620 ENOG4105E0A ABC, transporter B7R87_RS01670 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase B7R87_RS01705 ENOG4108KC1 acyl-Coa dehydrogenase B7R87_RS01710 ENOG4105CHR reductase B7R87_RS01725 ENOG4105C1G acyl-Coa dehydrogenase B7R87_RS01735 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase B7R87_RS01815 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B7R87_RS01820 ENOG4105CPF Cell wall formation (By similarity) B7R87_RS01825 ENOG4105CMT Dihydroxyacetone kinase B7R87_RS01830 ENOG4108UTZ Dihydroxyacetone kinase B7R87_RS01855 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) B7R87_RS01910 ENOG4105F8D glycoside hydrolase family 4 B7R87_RS01915 ENOG4105IDI abc transporter atp-binding protein B7R87_RS01925 ENOG4105D9P serine threonine protein kinase B7R87_RS02010 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) B7R87_RS02015 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) B7R87_RS02030 ENOG4106F1P AAA ATPase, central domain protein B7R87_RS02070 ENOG4105DKQ ROK family B7R87_RS02080 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS02085 ENOG4105BZU Histidine kinase B7R87_RS02100 ENOG4107QZT geranylgeranyl reductase B7R87_RS02105 ENOG4107PP3 Acetylornithine deacetylase B7R87_RS02110 ENOG4105C5X domain protein B7R87_RS02120 ENOG4105I1F Resistance protein B7R87_RS02130 ENOG4105ETE Transcriptional regulator (LacI family B7R87_RS02145 ENOG4105C10 Electron transfer flavoprotein B7R87_RS02155 ENOG4105PSQ Acyl-transferase B7R87_RS02170 ENOG4105C5W Aldolase B7R87_RS02185 ENOG4108QXE glycerophosphoryl diester phosphodiesterase B7R87_RS02205 ENOG410841Q phosphoesterase PA-phosphatase related protein B7R87_RS02235 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) B7R87_RS02255 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 B7R87_RS02280 ENOG4105D0M Protease HtpX homolog B7R87_RS02320 ENOG4105E9K Isocitrate dehydrogenase B7R87_RS02350 ENOG4105CSR polyphosphate kinase 2 B7R87_RS02365 ENOG4105DPX Hydrogenase, large subunit B7R87_RS02395 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) B7R87_RS02415 ENOG4105CQS hydrogenase expression formation protein HypD B7R87_RS02430 ENOG4105CJ1 ABC, transporter B7R87_RS02465 ENOG4105BZ1 (ABC) transporter B7R87_RS02495 ENOG4105S6R Iron-hydroxamate transporter permease subunit B7R87_RS02500 ENOG4108IHU transport system permease protein B7R87_RS02555 ENOG4105GRZ Ycii-related protein B7R87_RS02560 ENOG4105CHP RNA polymerase B7R87_RS02570 ENOG4105GMT ATPase associated with various cellular activities aaa_5 B7R87_RS02585 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) B7R87_RS02595 ENOG41065SU Two-component system sensor kinase B7R87_RS02600 ENOG4108KXV response regulator B7R87_RS02615 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) B7R87_RS02620 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) B7R87_RS02645 ENOG4105CEY Amp-dependent synthetase and ligase B7R87_RS02660 ENOG4105CEY Amp-dependent synthetase and ligase B7R87_RS02670 ENOG4105CEY Amp-dependent synthetase and ligase B7R87_RS02675 ENOG4105CEY Amp-dependent synthetase and ligase B7R87_RS02695 ENOG4105C5S asparaginyl-tRNA synthetase B7R87_RS02700 ENOG4105CBC glutamate synthase B7R87_RS02740 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase B7R87_RS02760 ENOG4106NZI LysR family Transcriptional regulator B7R87_RS02765 ENOG4105DTQ mandelate racemase muconate lactonizing B7R87_RS02770 ENOG4108QMY dioxygenase B7R87_RS02790 ENOG4105CHU acetyl-coa acetyltransferase B7R87_RS02800 ENOG4107W6X Transcriptional regulator B7R87_RS02810 ENOG41065KQ synthase B7R87_RS02815 ENOG4105C3J Cysteine desulfurase B7R87_RS02845 ENOG4108HHA Transketolase B7R87_RS02860 ENOG4105VEQ Cold shock protein B7R87_RS02865 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin B7R87_RS02880 ENOG4105GSW B7R87_RS02890 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit B7R87_RS02915 ENOG4108M24 von Willebrand factor, type A B7R87_RS02955 ENOG4105MKU Transcriptional regulator B7R87_RS02970 ENOG4108762 serine threonine protein kinase B7R87_RS02985 ENOG4107R37 Glutamate dehydrogenase B7R87_RS02990 ENOG4105F95 Monooxygenase B7R87_RS02995 ENOG4105BZ1 (ABC) transporter B7R87_RS03005 ENOG4105EPC oxidoreductase B7R87_RS03010 ENOG4105BZ1 (ABC) transporter B7R87_RS03015 ENOG4105BZ1 (ABC) transporter B7R87_RS03035 ENOG4105C29 acyl-CoA thioesterase B7R87_RS03040 ENOG4108V06 Glutathione peroxidase B7R87_RS03045 ENOG4105C1G acyl-Coa dehydrogenase B7R87_RS03055 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) B7R87_RS03065 ENOG4105F1K Glutamine amidotransferase B7R87_RS03070 ENOG4105CTQ phosphohexokinase B7R87_RS03085 ENOG4105F6E Acyl-transferase B7R87_RS03140 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) B7R87_RS03145 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) B7R87_RS03150 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) B7R87_RS03180 ENOG4105C83 adenylosuccinate lyase B7R87_RS03185 ENOG4108VCA G U mismatch-specific DNA glycosylase B7R87_RS03195 ENOG4105FDP GntR family transcriptional regulator B7R87_RS03220 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B7R87_RS03245 ENOG4108PSK reductase B7R87_RS03260 ENOG4105EYH Exonuclease B7R87_RS03265 ENOG4107RH8 nuclease SbcCD subunit D B7R87_RS03270 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein B7R87_RS03275 ENOG4105K4P CoA-binding domain protein B7R87_RS03340 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) B7R87_RS03350 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) B7R87_RS03360 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) B7R87_RS03370 ENOG4105EP9 oxidoreductase B7R87_RS03395 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) B7R87_RS03405 ENOG4105CHR reductase B7R87_RS03465 ENOG4106P55 Transcriptional regulator B7R87_RS03475 ENOG4105CSW GntR family transcriptional regulator B7R87_RS03515 ENOG4107TIF Phenazine biosynthesis protein, PhzF family B7R87_RS03540 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor B7R87_RS03550 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) B7R87_RS03570 ENOG4108UW8 fha domain-containing protein B7R87_RS03620 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) B7R87_RS03630 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) B7R87_RS03640 ENOG4105E09 nadh pyrophosphatase B7R87_RS03665 ENOG4105GWZ Roadblock lc7 family protein B7R87_RS03695 ENOG4105E7W lamb ycsf family protein B7R87_RS03700 ENOG4105P4J Allophanate hydrolase, subunit 1 B7R87_RS03705 ENOG4107R7A Allophanate hydrolase subunit 2 B7R87_RS03720 ENOG4105JXB ankyrin repeat-containing protein B7R87_RS03735 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B7R87_RS03755 ENOG4105Q70 B7R87_RS03765 ENOG4108HMN Caspase domain B7R87_RS03765 ENOG4108HMN Caspase domain B7R87_RS03770 ENOG4105FS0 cytoplasmic membrane protein B7R87_RS03775 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) B7R87_RS03785 ENOG4105EW9 transcriptional regulator AsnC family B7R87_RS03795 ENOG4105C1G acyl-Coa dehydrogenase B7R87_RS03835 ENOG4105JZI cytochrome P450 B7R87_RS03840 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) B7R87_RS03850 ENOG4108NDC ATP-binding protein yghS B7R87_RS03870 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) B7R87_RS03875 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase B7R87_RS03880 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) B7R87_RS03885 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) B7R87_RS03905 ENOG4105C5I Dehydrogenase B7R87_RS03915 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase B7R87_RS03920 ENOG4105E2R ROK family B7R87_RS03940 ENOG4105F6U Short-chain dehydrogenase reductase Sdr B7R87_RS03945 ENOG4108IND Tetr family transcriptional regulator B7R87_RS03975 ENOG4105DKT Transcriptional regulator B7R87_RS03980 ENOG4105DJV ribulose-phosphate 3-epimerase B7R87_RS03990 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) B7R87_RS04000 ENOG4107RSZ Primosomal protein n' B7R87_RS04005 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP B7R87_RS04020 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) B7R87_RS04030 ENOG4105SKN orotidine 5''-phosphate decarboxylase B7R87_RS04035 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) B7R87_RS04040 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain B7R87_RS04045 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain B7R87_RS04055 ENOG4105CD3 dihydroorotase B7R87_RS04060 ENOG4105CXT aspartate transcarbamylase B7R87_RS04065 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) B7R87_RS04075 ENOG410803B Involved in the transcription termination process (By similarity) B7R87_RS04080 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) B7R87_RS04085 ENOG4105DC7 peptidase M24 B7R87_RS04095 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) B7R87_RS04100 ENOG4105D49 3-dehydroquinate synthase B7R87_RS04105 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) B7R87_RS04110 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase B7R87_RS04120 ENOG4105HHA aminodeoxychorismate lyase B7R87_RS04125 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) B7R87_RS04130 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) B7R87_RS04145 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) B7R87_RS04165 ENOG4105CUT histidyl-tRNA synthetase B7R87_RS04180 ENOG4105C99 atpase involved in dna repair B7R87_RS04185 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) B7R87_RS04190 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) B7R87_RS04195 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) B7R87_RS04200 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) B7R87_RS04210 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) B7R87_RS04215 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) B7R87_RS04220 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) B7R87_RS04225 ENOG4105CDY transcriptional regulatory protein B7R87_RS04230 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) B7R87_RS04235 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) B7R87_RS04245 ENOG4105E2K Glycosyl transferase (Group 1 B7R87_RS04255 ENOG4108VTU Cdp-alcohol phosphatidyltransferase B7R87_RS04280 ENOG4105C22 threonyL-tRNA synthetase B7R87_RS04295 ENOG4108JDX DNA polymerase iii, epsilon subunit B7R87_RS04325 ENOG4105KF0 sporulation and cell division protein, SsgA B7R87_RS04350 ENOG4105F0I Aminotransferase B7R87_RS04355 ENOG4105CRQ synthase (Component I) B7R87_RS04410 ENOG4105EEM helicase B7R87_RS04420 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) B7R87_RS04425 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) B7R87_RS04440 ENOG4105D01 (LipO)protein B7R87_RS04445 ENOG4108UMI ABC transporter, permease B7R87_RS04470 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase B7R87_RS04475 ENOG4105CEY Amp-dependent synthetase and ligase B7R87_RS04480 ENOG4105C57 major facilitator superfamily B7R87_RS04485 ENOG4105RJZ Transcriptional regulator B7R87_RS04495 ENOG4105CH7 arginosuccinase B7R87_RS04500 ENOG4105CDH Citrulline--aspartate ligase B7R87_RS04510 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) B7R87_RS04515 ENOG4105C8Y Acetylornithine aminotransferase B7R87_RS04520 ENOG4105CAS nag kinase B7R87_RS04525 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) B7R87_RS04530 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase B7R87_RS04570 ENOG4105T38 integral membrane protein B7R87_RS04580 ENOG4105F32 YngK protein B7R87_RS04590 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) B7R87_RS04605 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) B7R87_RS04610 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) B7R87_RS04615 ENOG4105BZU Histidine kinase B7R87_RS04620 ENOG4108RWN rrna methyltransferase B7R87_RS04625 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) B7R87_RS04630 ENOG41084BS 50S ribosomal protein L35 B7R87_RS04635 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) B7R87_RS04680 ENOG4105C26 Dehydrogenase B7R87_RS04685 ENOG4105C5F glutamine synthetase B7R87_RS04690 ENOG41073TP transcriptional regulator B7R87_RS04695 ENOG4105C85 amino acid B7R87_RS04700 ENOG4108Z86 Glutamine amidotransferase B7R87_RS04715 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B7R87_RS04725 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein B7R87_RS04745 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) B7R87_RS04755 ENOG4108HQS Glycine betaine B7R87_RS04760 ENOG4108IJ7 Glycine betaine B7R87_RS04765 ENOG4105HFS 5'-3' exonuclease B7R87_RS04775 ENOG4108KQ5 Integrase catalytic subunit B7R87_RS04780 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase B7R87_RS04790 ENOG4105CVP deoxyribo-dipyrimidine photolyase B7R87_RS04805 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) B7R87_RS04810 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) B7R87_RS04840 ENOG4108V1T peptidylprolyl cis-trans isomerase B7R87_RS04845 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) B7R87_RS04855 ENOG4105ETE Transcriptional regulator (LacI family B7R87_RS04865 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) B7R87_RS04870 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) B7R87_RS04875 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) B7R87_RS04880 ENOG4105E5F proteasome B7R87_RS04885 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) B7R87_RS04915 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS04930 ENOG4105C3R Methionine synthase B7R87_RS04935 ENOG4108K8U Glycerol operon regulatory protein B7R87_RS04940 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) B7R87_RS04945 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) B7R87_RS04950 ENOG4105C6V Glycerol-3-phosphate dehydrogenase B7R87_RS04955 ENOG4105JXH GntR family transcriptional regulator B7R87_RS04965 ENOG4105C8N cysteinyl-tRNA synthetase B7R87_RS04990 ENOG4105DYW oxidoreductase B7R87_RS04995 ENOG4105CPC Aldo Keto reductase B7R87_RS05030 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) B7R87_RS05040 ENOG4105D3G Pseudouridine synthase B7R87_RS05060 ENOG4105C6F GntR Family Transcriptional Regulator B7R87_RS05065 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family B7R87_RS05070 ENOG4105C6Z Gluconate B7R87_RS05080 ENOG4105PTV Nudix Hydrolase B7R87_RS05085 ENOG4105VG5 Membrane B7R87_RS05090 ENOG4105JP4 Inner membrane protein yidG B7R87_RS05105 ENOG4108XG4 DNA-binding transcriptional regulator B7R87_RS05110 ENOG4105EHZ conserved protein UCP016719 B7R87_RS05145 ENOG4105C1G acyl-Coa dehydrogenase B7R87_RS05155 ENOG4105D4T Citrate transporter B7R87_RS05165 ENOG4105F1J Homogentisate 1,2-dioxygenase B7R87_RS05170 ENOG4105FDP GntR family transcriptional regulator B7R87_RS05180 ENOG4107TPY serine threonine protein kinase B7R87_RS05185 ENOG4108TCJ secreted hydrolase B7R87_RS05200 ENOG4105K64 Glycosyl transferase, family 2 B7R87_RS05205 ENOG4107BJW polysaccharide deacetylase B7R87_RS05215 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family B7R87_RS05245 ENOG4106YYS transcriptional regulatory protein B7R87_RS05320 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) B7R87_RS05325 ENOG4105C1G acyl-Coa dehydrogenase B7R87_RS05330 ENOG4105C57 major facilitator superfamily B7R87_RS05335 ENOG410841Q phosphoesterase PA-phosphatase related protein B7R87_RS05350 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) B7R87_RS05365 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) B7R87_RS05370 ENOG4105F6E Acyl-transferase B7R87_RS05375 ENOG4105CAT Cytidine monophosphate kinase B7R87_RS05385 ENOG4105KHN chorismate mutase B7R87_RS05390 ENOG4108UDB Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) B7R87_RS05400 ENOG410756H nucleotidyltransferase B7R87_RS05415 ENOG4105FE9 pseudouridine synthase B7R87_RS05420 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) B7R87_RS05425 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) B7R87_RS05440 ENOG4105DCF alanine dehydrogenase B7R87_RS05450 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) B7R87_RS05455 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) B7R87_RS05460 ENOG4105BZP glycoside hydrolase 15-related B7R87_RS05470 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) B7R87_RS05480 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) B7R87_RS05490 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) B7R87_RS05510 ENOG4105E0A ABC, transporter B7R87_RS05515 ENOG4105DSU hydrolase B7R87_RS05545 ENOG4108VX5 3-methyladenine DNA glycosylase B7R87_RS05555 ENOG4108V1U phospholipid-binding protein B7R87_RS05580 ENOG4105DKW ABC transporter B7R87_RS05600 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS05605 ENOG4105ENE Histidine kinase B7R87_RS05620 ENOG4105IDI abc transporter atp-binding protein B7R87_RS05630 ENOG4105EAC phosphoserine phosphatase B7R87_RS05645 ENOG4105DJ2 Major Facilitator Superfamily B7R87_RS05650 ENOG4107YCY Transcriptional regulator B7R87_RS05660 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH B7R87_RS05665 ENOG4105CHR reductase B7R87_RS05680 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) B7R87_RS05700 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) B7R87_RS05705 ENOG4107QN1 sodium solute B7R87_RS05735 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) B7R87_RS05750 ENOG4105BZP glycoside hydrolase 15-related B7R87_RS05800 ENOG4105C5H ABC transporter B7R87_RS05815 ENOG4107W7X Aldolase B7R87_RS05830 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) B7R87_RS05835 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) B7R87_RS05850 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) B7R87_RS05890 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) B7R87_RS05960 ENOG4105C3J Cysteine desulfurase B7R87_RS05985 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase B7R87_RS05990 ENOG4108ZT1 Transcriptional regulator B7R87_RS06005 ENOG4105CJN penicillin-binding protein B7R87_RS06075 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) B7R87_RS06080 ENOG4108RFG Tetr family transcriptional regulator B7R87_RS06085 ENOG410814C multidrug resistance protein B7R87_RS06090 ENOG4105VG1 fes assembly suf system protein B7R87_RS06095 ENOG4108UNV SUF system FeS assembly protein, NifU family B7R87_RS06100 ENOG4105C9B Cysteine desulfurase B7R87_RS06105 ENOG4105C3K feS assembly ATPase SufC B7R87_RS06115 ENOG4105JRK feS assembly protein SufD B7R87_RS06140 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) B7R87_RS06150 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) B7R87_RS06155 ENOG4105CV1 Transketolase (EC 2.2.1.1) B7R87_RS06160 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) B7R87_RS06175 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) B7R87_RS06180 ENOG4105K7W phage-related replication protein B7R87_RS06190 ENOG4107QP8 phosphohexose isomerase B7R87_RS06205 ENOG4105CP7 Triose-phosphate isomerase B7R87_RS06210 ENOG4105BZA Phosphoglycerate kinase B7R87_RS06215 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase B7R87_RS06225 ENOG4105CIE May be required for sporulation (By similarity) B7R87_RS06230 ENOG4105CHW UPF0052 protein B7R87_RS06235 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) B7R87_RS06240 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) B7R87_RS06270 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) B7R87_RS06285 ENOG4106F60 Histidine kinase B7R87_RS06290 ENOG4105F44 Two component transcriptional regulator, winged helix family B7R87_RS06305 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) B7R87_RS06310 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) B7R87_RS06330 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) B7R87_RS06335 ENOG4105BZU Histidine kinase B7R87_RS06340 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) B7R87_RS06345 ENOG4105DXI Major Facilitator superfamily B7R87_RS06350 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) B7R87_RS06370 ENOG4105C0D helicase B7R87_RS06390 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) B7R87_RS06400 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) B7R87_RS06410 ENOG4105CQ7 ATP-dependent helicase B7R87_RS06440 ENOG4105KA0 thioesterase Superfamily protein B7R87_RS06450 ENOG4105C32 Amino acid ABC transporter (Permease) B7R87_RS06455 ENOG4105CF8 branched-chain amino acid ABC transporter, permease B7R87_RS06460 ENOG4105C0Z ABC transporter B7R87_RS06465 ENOG4108IV0 ABC, transporter B7R87_RS06490 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) B7R87_RS06505 ENOG4105EHE chorismate mutase- prephenate dehydrogenase B7R87_RS06525 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr B7R87_RS06550 ENOG4105EA8 2-Nitropropane dioxygenase B7R87_RS06565 ENOG4105F2C Acetyl-CoA acetyltransferase B7R87_RS06570 ENOG4108RZE Tetr family transcriptional regulator B7R87_RS06580 ENOG4105CC9 acyl-Coa dehydrogenase B7R87_RS06585 ENOG4105C1G acyl-Coa dehydrogenase B7R87_RS06610 ENOG4105CBC glutamate synthase B7R87_RS06620 ENOG41065RQ ADP-ribosylation crystallin J1 B7R87_RS06640 ENOG4108RVA ribokinase B7R87_RS06645 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F B7R87_RS06655 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) B7R87_RS06665 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) B7R87_RS06670 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) B7R87_RS06680 ENOG4105DK0 Indole-3-glycerol phosphate synthase B7R87_RS06700 ENOG4105CRQ synthase (Component I) B7R87_RS06705 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase B7R87_RS06715 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) B7R87_RS06720 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase B7R87_RS06725 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) B7R87_RS06730 ENOG4105ECC imidazole-glycerol-phosphate dehydratase B7R87_RS06735 ENOG4105CIH Imidazole acetol-phosphate transaminase B7R87_RS06740 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) B7R87_RS06760 ENOG4108Z66 YbaK ebsC protein B7R87_RS06785 ENOG4105C0B DNA polymerase III (alpha subunit) B7R87_RS06820 ENOG4107SUZ Sodium/hydrogen exchanger family B7R87_RS06830 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) B7R87_RS06835 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters B7R87_RS06840 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) B7R87_RS06855 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) B7R87_RS06860 ENOG4105DFA alanine racemase domain protein B7R87_RS06865 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase B7R87_RS06870 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) B7R87_RS06880 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) B7R87_RS06890 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) B7R87_RS06895 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) B7R87_RS06905 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) B7R87_RS06910 ENOG4105CJN penicillin-binding protein B7R87_RS06920 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) B7R87_RS06930 ENOG4105C7R Atpase associated with various cellular activities aaa_3 B7R87_RS06960 ENOG4105FDK ABC transporter B7R87_RS06970 ENOG4107Z3H Transcriptional regulator, TetR family B7R87_RS06975 ENOG4107VFM Dehydrogenase B7R87_RS06990 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) B7R87_RS07030 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) B7R87_RS07040 ENOG4108UQY Iron-storage protein B7R87_RS07050 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase B7R87_RS07060 ENOG4105C5I Dehydrogenase B7R87_RS07065 ENOG4105CTQ phosphohexokinase B7R87_RS07070 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS07075 ENOG4105ENE Histidine kinase B7R87_RS07100 ENOG4105DKQ ROK family B7R87_RS07110 ENOG4105D0U Arsenite-activated ATPase (ArsA) B7R87_RS07130 ENOG4105JNK Glycosyl transferase (Group 1 B7R87_RS07180 ENOG4106F60 Histidine kinase B7R87_RS07185 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7R87_RS07195 ENOG4105BZW Glycerate kinase B7R87_RS07200 ENOG4105C9B Cysteine desulfurase B7R87_RS07205 ENOG4108I0Q anthranilate phosphoribosyltransferase B7R87_RS07210 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) B7R87_RS07215 ENOG4107EUI c reductase, iron-sulfur B7R87_RS07220 ENOG4107UDY cytochrome C B7R87_RS07225 ENOG4105CCU oxidase (Subunit III) B7R87_RS07240 ENOG4105MCD Part of cytochrome c oxidase, its function is B7R87_RS07245 ENOG4105BZ9 Cytochrome C oxidase, subunit I B7R87_RS07250 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) B7R87_RS07255 ENOG4105C3J Cysteine desulfurase B7R87_RS07285 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) B7R87_RS07300 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS07305 ENOG4105BZU Histidine kinase B7R87_RS07335 ENOG4105C0H protease B7R87_RS07345 ENOG4108YZT Adenosylcobinamide kinase B7R87_RS07350 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) B7R87_RS07355 ENOG4105CRK lysyL-tRNA synthetase B7R87_RS07375 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) B7R87_RS07395 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) B7R87_RS07440 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) B7R87_RS07445 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) B7R87_RS07475 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) B7R87_RS07485 ENOG4108222 arsenate reductase B7R87_RS07505 ENOG4107R5B glutamine synthetase B7R87_RS07510 ENOG4107NHD transcriptional regulator B7R87_RS07535 ENOG4108XG2 Histidine kinase B7R87_RS07540 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS07575 ENOG4105D56 permease protein B7R87_RS07580 ENOG4105EG2 ABC transporter, permease B7R87_RS07585 ENOG4105CG3 alpha amylase, catalytic region B7R87_RS07590 ENOG4105ETE Transcriptional regulator (LacI family B7R87_RS07600 ENOG4105C57 major facilitator superfamily B7R87_RS07630 ENOG4105C85 amino acid B7R87_RS07640 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) B7R87_RS07670 ENOG4105BZU Histidine kinase B7R87_RS07675 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS07680 ENOG4105C5F glutamine synthetase B7R87_RS07705 ENOG4106HB6 Alpha beta hydrolase B7R87_RS07720 ENOG4107R16 Multicopper oxidase B7R87_RS07725 ENOG4105C4K Nad synthetase B7R87_RS07740 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) B7R87_RS07760 ENOG4107XZ0 Peptidase M50 B7R87_RS07830 ENOG4105EWN Heme oxygenase B7R87_RS07850 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) B7R87_RS07855 ENOG4105EHG Permease protein B7R87_RS07860 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) B7R87_RS07890 ENOG4105KME endoribonuclease L-psp B7R87_RS07920 ENOG4108C33 Resolvase B7R87_RS07925 ENOG4107RSM transcriptional regulator B7R87_RS07930 ENOG4105NAE bifunctional deaminase-reductase domain protein B7R87_RS07945 ENOG4106A0S B7R87_RS07960 ENOG4105CIK Amidinotransferase B7R87_RS07970 ENOG4105C2C drug resistance transporter, Bcr CflA B7R87_RS07975 ENOG4105DGI Alkaline phosphatase B7R87_RS08000 ENOG4105GFR rna polymerase sigma factor B7R87_RS08015 ENOG4105D9P serine threonine protein kinase B7R87_RS08025 ENOG4108HMN Caspase domain B7R87_RS08050 ENOG4107XFJ UPF0246 protein B7R87_RS08055 ENOG4108UHU Aldolase B7R87_RS08060 ENOG4105CVJ phosphoglycerate mutase B7R87_RS08070 ENOG4105EGD dinuclear metal center protein, YbgI family B7R87_RS08105 ENOG4105CHU acetyl-coa acetyltransferase B7R87_RS08110 ENOG4105D2B acyl-CoA dehydrogenase B7R87_RS08130 ENOG4105DYW oxidoreductase B7R87_RS08140 ENOG4107QVI Methyltransferase, type 11 B7R87_RS08150 ENOG4108SGK Tetr family transcriptional regulator B7R87_RS08190 ENOG4105BZ1 (ABC) transporter B7R87_RS08220 ENOG4105F2C Acetyl-CoA acetyltransferase B7R87_RS08225 ENOG4106A3M Cytochrome p-450 B7R87_RS08250 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 B7R87_RS08285 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C B7R87_RS08350 ENOG4107T5V SNARE associated Golgi B7R87_RS08360 ENOG4105DAX Pfam:DUF2983 B7R87_RS08405 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) B7R87_RS08430 ENOG4105BZU Histidine kinase B7R87_RS08435 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS08440 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase B7R87_RS08465 ENOG4108FN7 Aldo keto reductase B7R87_RS08470 ENOG4105VUF Transcriptional regulator B7R87_RS08500 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) B7R87_RS08520 ENOG4105NGS secreted protein B7R87_RS08540 ENOG4108ZHJ Organic hydroperoxide resistance protein B7R87_RS08545 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein B7R87_RS08565 ENOG4105DFF Rod shape-determining protein mreb B7R87_RS08580 ENOG4105EW9 transcriptional regulator AsnC family B7R87_RS08595 ENOG4105CEY Amp-dependent synthetase and ligase B7R87_RS08615 ENOG4105X1Q TOBE domain protein B7R87_RS08645 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) B7R87_RS08650 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) B7R87_RS08700 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B7R87_RS08705 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) B7R87_RS08715 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein B7R87_RS08720 ENOG4108UB4 uncharacterized protein ygjQ B7R87_RS08750 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) B7R87_RS08760 ENOG4105C0X amino acid B7R87_RS08770 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) B7R87_RS08790 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) B7R87_RS08795 ENOG4105DSE periplasmic solute binding protein B7R87_RS08800 ENOG4105FDK ABC transporter B7R87_RS08820 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) B7R87_RS08825 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) B7R87_RS08835 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) B7R87_RS08840 ENOG4105D4Y metalloprotease B7R87_RS08850 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) B7R87_RS08875 ENOG4105MSB protein, conserved in bacteria B7R87_RS08885 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) B7R87_RS08905 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) B7R87_RS08910 ENOG4107YU2 histidine triad (hIT) protein B7R87_RS08925 ENOG4107QWG 2-Nitropropane dioxygenase B7R87_RS08930 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) B7R87_RS08935 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) B7R87_RS08960 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) B7R87_RS08965 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) B7R87_RS08980 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase B7R87_RS08990 ENOG4105KQC Competence protein B7R87_RS08995 ENOG4105EPR degv family B7R87_RS09005 ENOG4105C8T Leucyl-tRNA synthetase B7R87_RS09045 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) B7R87_RS09050 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) B7R87_RS09060 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) B7R87_RS09065 ENOG4105D0M Protease HtpX homolog B7R87_RS09080 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) B7R87_RS09090 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) B7R87_RS09105 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) B7R87_RS09110 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control B7R87_RS09115 ENOG4105K46 50S ribosomal protein l27 B7R87_RS09120 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) B7R87_RS09125 ENOG4105J5G Transferase hexapeptide repeat containing protein B7R87_RS09135 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) B7R87_RS09140 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase B7R87_RS09150 ENOG4108IJ1 Dehydrogenase B7R87_RS09160 ENOG4105CK5 oxidoreductase B7R87_RS09165 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase B7R87_RS09170 ENOG4105C03 ribonuclease B7R87_RS09190 ENOG4105CNI cell division protein FtsW B7R87_RS09210 ENOG4105DFF Rod shape-determining protein mreb B7R87_RS09215 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) B7R87_RS09225 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase B7R87_RS09230 ENOG4105BZU Histidine kinase B7R87_RS09235 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) B7R87_RS09245 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) B7R87_RS09250 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) B7R87_RS09255 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) B7R87_RS09260 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation B7R87_RS09280 ENOG4107S91 Sodium hydrogen exchanger B7R87_RS09290 ENOG4105CHP RNA polymerase B7R87_RS09330 ENOG4105C85 amino acid B7R87_RS09340 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) B7R87_RS09345 ENOG4105MC2 DSBA oxidoreductase B7R87_RS09360 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin B7R87_RS09415 ENOG4108KTG Membrane protein, drug metabolite transporter B7R87_RS09420 ENOG4108ZT1 Transcriptional regulator B7R87_RS09435 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 B7R87_RS09445 ENOG4105D8X mechanosensitive ion channel B7R87_RS09455 ENOG4105BZ7 extracellular solute-binding protein family 1 B7R87_RS09465 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component B7R87_RS09470 ENOG4105F8D glycoside hydrolase family 4 B7R87_RS09485 ENOG4105CT1 (ABC) transporter B7R87_RS09520 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) B7R87_RS09555 ENOG4105VHU single-stranded DNA-binding protein B7R87_RS09560 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control B7R87_RS09585 ENOG4107F2M hemolysin-type calcium-binding region B7R87_RS09625 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) B7R87_RS09635 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS09655 ENOG4105CHH sulfate transporter B7R87_RS09660 ENOG4107B2H carbonic anhydrase B7R87_RS09670 ENOG4106F60 Histidine kinase B7R87_RS09680 ENOG4105E8V Alpha Beta Hydrolase Fold protein B7R87_RS09695 ENOG4105CJ1 ABC, transporter B7R87_RS09710 ENOG4105C26 Dehydrogenase B7R87_RS09715 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) B7R87_RS09720 ENOG4105DH8 myo-inositol catabolism B7R87_RS09735 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) B7R87_RS09745 ENOG4105D9U N-acetyltransferase B7R87_RS09760 ENOG4105C7H Helicase, RecD TraA family B7R87_RS09780 ENOG41060NJ transcriptional regulator B7R87_RS09785 ENOG410645S MarR family Transcriptional regulator B7R87_RS09795 ENOG4108594 Permease of the drug metabolite transporter B7R87_RS09805 ENOG4105D17 glycoside hydrolase, family 3 domain protein B7R87_RS09835 ENOG4105C7K acetolactate synthase B7R87_RS09860 ENOG4105C29 acyl-CoA thioesterase B7R87_RS09870 ENOG4108XFF B7R87_RS09880 ENOG4107QX3 carboxylase B7R87_RS09890 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase B7R87_RS09895 ENOG4105C1G acyl-Coa dehydrogenase B7R87_RS09910 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) B7R87_RS09920 ENOG4105DUU IucA IucC family protein B7R87_RS09925 ENOG4105E2D ec 3.2.1.52 B7R87_RS09940 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) B7R87_RS09955 ENOG4105ECQ AraC Family Transcriptional Regulator B7R87_RS09960 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) B7R87_RS09970 ENOG410804D Sensor Signal Transduction Histidine Kinase B7R87_RS09975 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7R87_RS10020 ENOG4108ZM9 phosphoglycerate mutase B7R87_RS10045 ENOG4105BZU Histidine kinase B7R87_RS10055 ENOG4105DEN Luciferase family B7R87_RS10095 ENOG4108M1A Chitin-binding protein B7R87_RS10130 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) B7R87_RS10135 ENOG4105D9R oxidoreductase B7R87_RS10140 ENOG41090KN UPF0303 protein B7R87_RS10150 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins B7R87_RS10160 ENOG4108U4N (sortase) family B7R87_RS10180 ENOG4106BRA Membrane B7R87_RS10190 ENOG4108IUW ABC transporter B7R87_RS10205 ENOG4105BZ4 penicillin-binding protein B7R87_RS10210 ENOG4105KPY Small multidrug resistance protein B7R87_RS10215 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) B7R87_RS10235 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) B7R87_RS10245 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) B7R87_RS10250 ENOG4105CI1 PTS System B7R87_RS10265 ENOG4108RQ5 Beta-lactamase domain-containing protein B7R87_RS10330 ENOG41082K6 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) B7R87_RS10345 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) B7R87_RS10350 ENOG4105EHG Permease protein B7R87_RS10355 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) B7R87_RS10365 ENOG4105C85 amino acid B7R87_RS10380 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) B7R87_RS10390 ENOG4108RWI nicotinamidase B7R87_RS10400 ENOG4107G87 m6 family metalloprotease domain protein B7R87_RS10425 ENOG4107TV1 YD repeat protein B7R87_RS10430 ENOG4105KF0 sporulation and cell division protein, SsgA B7R87_RS10445 ENOG4107S9F NmrA family B7R87_RS10450 ENOG4105CQB FAD linked oxidase domain protein B7R87_RS10470 ENOG4105EB3 Histidine kinase B7R87_RS10475 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7R87_RS10480 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase B7R87_RS10490 ENOG41063PX domain protein B7R87_RS10505 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) B7R87_RS10590 ENOG4108EJ0 Catalyzes the synthesis of activated sulfate (By similarity) B7R87_RS10595 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding B7R87_RS10610 ENOG4105E2D ec 3.2.1.52 B7R87_RS10620 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component B7R87_RS10635 ENOG4108UJU UPF0301 protein B7R87_RS10640 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) B7R87_RS10645 ENOG4108426 dNA-binding protein B7R87_RS10655 ENOG4105EEM helicase B7R87_RS10655 ENOG4105EEM helicase B7R87_RS10680 ENOG4106NZI LysR family Transcriptional regulator B7R87_RS10695 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) B7R87_RS10710 ENOG4105CAK Cell division ATP-binding protein ftsE B7R87_RS10730 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) B7R87_RS10735 ENOG4108QVN serine threonine protein kinase B7R87_RS10740 ENOG4108UGD Serine Threonine protein kinase B7R87_RS10750 ENOG4105EPJ extracellular solute-binding protein family 1 B7R87_RS10760 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component B7R87_RS10785 ENOG4105C7I Dehydrogenase B7R87_RS10790 ENOG4107R7Y intracellular protease Pfpi family B7R87_RS10810 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving B7R87_RS10820 ENOG4105T0Z Conserved Protein B7R87_RS10825 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS10830 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea B7R87_RS10840 ENOG4105G3P Lipoprotein lpqB B7R87_RS10845 ENOG4105BZU Histidine kinase B7R87_RS10850 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7R87_RS10855 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) B7R87_RS10870 ENOG4108WQ6 secreted protein B7R87_RS10875 ENOG4105C7R Atpase associated with various cellular activities aaa_3 B7R87_RS10915 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) B7R87_RS10925 ENOG4105EIP mannose-6-phosphate isomerase B7R87_RS10935 ENOG4105W49 UPF0434 protein B7R87_RS10965 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) B7R87_RS10975 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase B7R87_RS10980 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) B7R87_RS11000 ENOG4108KGH TRANSCRIPTIONal B7R87_RS11005 ENOG4108KGH TRANSCRIPTIONal B7R87_RS11020 ENOG4108S4H thioesterase Superfamily protein B7R87_RS11025 ENOG4108KGH TRANSCRIPTIONal B7R87_RS11045 ENOG4105C6Y Udp-glucose 6-dehydrogenase B7R87_RS11080 ENOG41065SU Two-component system sensor kinase B7R87_RS11085 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7R87_RS11090 ENOG4105DUX Transporter B7R87_RS11105 ENOG4105CHR reductase B7R87_RS11110 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) B7R87_RS11130 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) B7R87_RS11135 ENOG410900P UPF0336 protein B7R87_RS11145 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) B7R87_RS11160 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase B7R87_RS11170 ENOG4105EWK phytoene B7R87_RS11175 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) B7R87_RS11190 ENOG4105C1G acyl-Coa dehydrogenase B7R87_RS11205 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) B7R87_RS11220 ENOG4108IQE Amp-dependent synthetase and ligase B7R87_RS11290 ENOG4108RJ7 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity) B7R87_RS11295 ENOG4108IG5 Transcriptional regulator B7R87_RS11300 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) B7R87_RS11315 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B7R87_RS11395 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) B7R87_RS11420 ENOG4108SQ9 flavin reductase domain protein, FMN-binding B7R87_RS11425 ENOG4108ZHR arsR family transcriptional regulator B7R87_RS11445 ENOG4105ECR NmrA family B7R87_RS11475 ENOG4105CI2 imidazolone-5-propionate hydrolase B7R87_RS11490 ENOG4105CGP Urocanate hydratase B7R87_RS11535 ENOG4105CHU acetyl-coa acetyltransferase B7R87_RS11565 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) B7R87_RS11570 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) B7R87_RS11575 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase B7R87_RS11580 ENOG4105CEP NADH dehydrogenase B7R87_RS11600 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) B7R87_RS11615 ENOG4106A3M Cytochrome p-450 B7R87_RS11720 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) B7R87_RS11725 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) B7R87_RS11755 ENOG4105ENE Histidine kinase B7R87_RS11765 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) B7R87_RS11770 ENOG4105C5T Phosphoribosyl pyrophosphate synthase B7R87_RS11775 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) B7R87_RS11780 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) B7R87_RS11795 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) B7R87_RS11810 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) B7R87_RS11815 ENOG4108ZT1 Transcriptional regulator B7R87_RS11820 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS11845 ENOG4105C5H ABC transporter B7R87_RS11860 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) B7R87_RS11865 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) B7R87_RS11885 ENOG4105F8V Hydrolase, tatD family B7R87_RS11905 ENOG4107RVG penicillin-binding protein B7R87_RS11910 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) B7R87_RS11920 ENOG4105CJ1 ABC, transporter B7R87_RS11935 ENOG4108UV1 cellular component movement B7R87_RS11960 ENOG4108JJB ABC transporter B7R87_RS11970 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) B7R87_RS11975 ENOG4105KF0 sporulation and cell division protein, SsgA B7R87_RS11980 ENOG4105EYF MMPL domain protein B7R87_RS12010 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) B7R87_RS12015 ENOG4105F95 Monooxygenase B7R87_RS12055 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) B7R87_RS12080 ENOG4105KV4 Transcriptional regulator B7R87_RS12100 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone B7R87_RS12120 ENOG4105DDW LysR family Transcriptional regulator B7R87_RS12150 ENOG4108RIR Molybdenum cofactor biosynthesis protein B7R87_RS12155 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) B7R87_RS12165 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase B7R87_RS12170 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase B7R87_RS12175 ENOG4105CUJ penicillin amidase B7R87_RS12195 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) B7R87_RS12205 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) B7R87_RS12225 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein B7R87_RS12230 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) B7R87_RS12280 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b B7R87_RS12305 ENOG4105CEY Amp-dependent synthetase and ligase B7R87_RS12340 ENOG4105EC2 ftsk spoIIIe B7R87_RS12345 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) B7R87_RS12355 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) B7R87_RS12360 ENOG4105EM7 Selenocysteine-specific translation elongation factor B7R87_RS12365 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) B7R87_RS12480 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) B7R87_RS12505 ENOG4108UV1 cellular component movement B7R87_RS12610 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) B7R87_RS12690 ENOG4105CHR reductase B7R87_RS12765 ENOG4108ZJ4 polysaccharide deacetylase B7R87_RS12770 ENOG4105F0K SARP family transcriptional regulator B7R87_RS12810 ENOG4105CEY Amp-dependent synthetase and ligase B7R87_RS12825 ENOG4105E39 Enoyl-CoA hydratase B7R87_RS12840 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) B7R87_RS12870 ENOG4105D2B acyl-CoA dehydrogenase B7R87_RS12900 ENOG4105H3G oxidoreductase B7R87_RS12910 ENOG4105CMV Succinyl-CoA synthetase subunit beta B7R87_RS12915 ENOG4105CGU Enoyl-CoA hydratase B7R87_RS12960 ENOG4105DCM major facilitator superfamily B7R87_RS12965 ENOG4105ECQ AraC Family Transcriptional Regulator B7R87_RS13015 ENOG4105CC9 acyl-Coa dehydrogenase B7R87_RS13035 ENOG4105D2B acyl-CoA dehydrogenase B7R87_RS13040 ENOG4105CC9 acyl-Coa dehydrogenase B7R87_RS13045 ENOG4105CEY Amp-dependent synthetase and ligase B7R87_RS13050 ENOG4105C57 major facilitator superfamily B7R87_RS13150 ENOG4108XEP Alpha Beta Hydrolase Fold protein B7R87_RS13160 ENOG4108SU4 UPF0309 protein B7R87_RS13165 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) B7R87_RS13185 ENOG4107AQZ Membrane B7R87_RS13190 ENOG4106NZI LysR family Transcriptional regulator B7R87_RS13195 ENOG4105CQB FAD linked oxidase domain protein B7R87_RS13205 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) B7R87_RS13245 ENOG4105CKK Glycosyl transferase, family 2 B7R87_RS13250 ENOG4105CPC Aldo Keto reductase B7R87_RS13265 ENOG4105XMC MarR family Transcriptional regulator B7R87_RS13275 ENOG4105C1J atp-dependent rna helicase B7R87_RS13290 ENOG4105C7N Xanthine uracil vitamin C permease B7R87_RS13300 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic B7R87_RS13325 ENOG4108N0W Major Facilitator superfamily B7R87_RS13335 ENOG4108UIH futalosine nucleosidase B7R87_RS13340 ENOG4105E63 Pfam:DUF178 B7R87_RS13345 ENOG4105VEQ Cold shock protein B7R87_RS13370 ENOG4105CFI type iii restriction protein res subunit B7R87_RS13385 ENOG4105EEM helicase B7R87_RS13400 ENOG4106N3A copper homeostasis protein cutc B7R87_RS13445 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) B7R87_RS13450 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate B7R87_RS13530 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) B7R87_RS13560 ENOG4105C3Q Glycosyl transferase, family 2 B7R87_RS13620 ENOG4105WWF Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) B7R87_RS13660 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) B7R87_RS13675 ENOG4105CE4 GlcNAc 6-P deacetylase B7R87_RS13680 ENOG4105DE4 1-phosphofructokinase B7R87_RS13685 ENOG4105D2N Aldolase B7R87_RS13700 ENOG4105BZU Histidine kinase B7R87_RS13710 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) B7R87_RS13740 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS13745 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) B7R87_RS13810 ENOG4105CJP fad dependent oxidoreductase B7R87_RS13815 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) B7R87_RS13825 ENOG4108IJ9 (ABC) transporter B7R87_RS13835 ENOG4107T65 Integrase B7R87_RS13845 ENOG4107ZVI PhiRv2 prophage protein B7R87_RS13940 ENOG4105H9W Short-chain dehydrogenase reductase Sdr B7R87_RS13975 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase B7R87_RS13980 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein B7R87_RS13990 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) B7R87_RS14020 ENOG4105BZ4 penicillin-binding protein B7R87_RS14030 ENOG4105CIS alcohol dehydrogenase B7R87_RS14040 ENOG4105C2N RNA methyltransferase TrmH family group 3 B7R87_RS14045 ENOG4105C8N cysteinyl-tRNA synthetase B7R87_RS14050 ENOG410905P Pyridoxamine 5-phosphate B7R87_RS14055 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) B7R87_RS14060 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) B7R87_RS14065 ENOG4108VJ1 Transcriptional regulator (CarD family B7R87_RS14085 ENOG4105BZU Histidine kinase B7R87_RS14095 ENOG4105E5W Transporter B7R87_RS14100 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) B7R87_RS14175 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) B7R87_RS14230 ENOG4105D74 hydrolase B7R87_RS14260 ENOG4108UYE Lactoylglutathione lyase B7R87_RS14295 ENOG4105YIP Tetr family transcriptional regulator B7R87_RS14300 ENOG4105HHS UPF0256 protein B7R87_RS14315 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) B7R87_RS14320 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) B7R87_RS14330 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands B7R87_RS14365 ENOG4105PKJ carbohydrate binding B7R87_RS14370 ENOG4105KHC sulfurtransferase B7R87_RS14375 ENOG4105J7D transcriptional regulator B7R87_RS14400 ENOG4107NHD transcriptional regulator B7R87_RS14405 ENOG4105ETE Transcriptional regulator (LacI family B7R87_RS14430 ENOG4105ERH Fumarylacetoacetate hydrolase B7R87_RS14465 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) B7R87_RS14475 ENOG4105C0H protease B7R87_RS14480 ENOG4105ETX regulatoR B7R87_RS14495 ENOG4105CGH 5'-nucleotidase B7R87_RS14515 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) B7R87_RS14520 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) B7R87_RS14535 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) B7R87_RS14550 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) B7R87_RS14560 ENOG4105CJ3 phosphate transporter B7R87_RS14570 ENOG4105VPX protein, conserved in bacteria B7R87_RS14585 ENOG4105DNP FAD linked oxidase domain protein B7R87_RS14595 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase B7R87_RS14600 ENOG4105E4C Lytic transglycosylase catalytic B7R87_RS14635 ENOG4105CJ1 ABC, transporter B7R87_RS14645 ENOG4105BZU Histidine kinase B7R87_RS14650 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS14680 ENOG4108Q50 Histidine kinase B7R87_RS14715 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS14720 ENOG4105BZU Histidine kinase B7R87_RS14750 ENOG4105D5U fad dependent oxidoreductase B7R87_RS14755 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) B7R87_RS14765 ENOG4105E4C Lytic transglycosylase catalytic B7R87_RS14780 ENOG4107TXC Transcriptional regulator B7R87_RS14785 ENOG4105CHP RNA polymerase B7R87_RS14910 ENOG4105C1J atp-dependent rna helicase B7R87_RS14920 ENOG41083TI Protein CrcB homolog B7R87_RS14925 ENOG41083YR Protein CrcB homolog B7R87_RS14960 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) B7R87_RS14970 ENOG4105CQ7 ATP-dependent helicase B7R87_RS14985 ENOG4108TAC B7R87_RS15000 ENOG4105CXB phosphoribosylaminoimidazole synthetase B7R87_RS15030 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii B7R87_RS15035 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I B7R87_RS15040 ENOG410839H phosphoribosylformylglycinamidine synthase B7R87_RS15060 ENOG4105CJ1 ABC, transporter B7R87_RS15085 ENOG4105C8V SAICAR synthetase B7R87_RS15100 ENOG4105C12 Phosphoribosylglycinamide synthetase B7R87_RS15125 ENOG4105C5S asparaginyl-tRNA synthetase B7R87_RS15140 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) B7R87_RS15190 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) B7R87_RS15195 ENOG4105NX3 Membrane B7R87_RS15215 ENOG4105C57 major facilitator superfamily B7R87_RS15225 ENOG4105WZW rhodanese family B7R87_RS15230 ENOG4105XTG Pfam:DUF156 B7R87_RS15280 ENOG4105IIU Aminopeptidase B7R87_RS15285 ENOG4105D7A ATP-binding protein B7R87_RS15300 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) B7R87_RS15315 ENOG4108Z6B deaminase B7R87_RS15335 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein B7R87_RS15345 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B7R87_RS15360 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes B7R87_RS15375 ENOG4105C57 major facilitator superfamily B7R87_RS15410 ENOG4105CEY Amp-dependent synthetase and ligase B7R87_RS15415 ENOG4105NAF rna polymerase sigma factor B7R87_RS15470 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) B7R87_RS15475 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B7R87_RS15515 ENOG4105CMD Transcriptional regulator, GntR family B7R87_RS15575 ENOG4107T6F Xaa-Pro aminopeptidase B7R87_RS15610 ENOG4105JDN Copper resistance protein B7R87_RS15615 ENOG4105DBE peroxidase B7R87_RS15625 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) B7R87_RS15630 ENOG410667J hydrolase B7R87_RS15680 ENOG4108K4B hydrolase B7R87_RS15685 ENOG4105E4C Lytic transglycosylase catalytic B7R87_RS15695 ENOG4108JJ9 ABC, transporter B7R87_RS15700 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii B7R87_RS15705 ENOG4105C4M (Ubiquinol oxidase) subunit I B7R87_RS15710 ENOG4105CIH Imidazole acetol-phosphate transaminase B7R87_RS15715 ENOG4107P2S Transcriptional regulator B7R87_RS15720 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) B7R87_RS15730 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) B7R87_RS15755 ENOG4106048 Cupin 2, conserved barrel domain protein B7R87_RS15760 ENOG4105C28 cystathionine B7R87_RS15785 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) B7R87_RS15800 ENOG4105CDU Replicative dna helicase B7R87_RS15810 ENOG4105K9Q Binds to the 23S rRNA (By similarity) B7R87_RS15815 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) B7R87_RS15820 ENOG4107YH6 single-stranded DNA-binding protein B7R87_RS15825 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) B7R87_RS15850 ENOG4105BZ4 penicillin-binding protein B7R87_RS15860 ENOG4105CZA synthase B7R87_RS15885 ENOG4105D9P serine threonine protein kinase B7R87_RS15900 ENOG4105C3M thioredoxin reductase B7R87_RS15905 ENOG4105K63 Thioredoxin B7R87_RS15920 ENOG4107QJE Chromosome Partitioning Protein B7R87_RS15925 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) B7R87_RS15935 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins B7R87_RS15940 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) B7R87_RS15945 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) B7R87_RS15950 ENOG41084CH 50S ribosomal protein l34 B7R87_RS15960 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) B7R87_RS15965 ENOG4108J5G 6-phosphogluconate dehydrogenase B7R87_RS15970 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) B7R87_RS15975 ENOG4105K7N UPF0232 protein B7R87_RS15985 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) B7R87_RS16010 ENOG4108UGD Serine Threonine protein kinase B7R87_RS16030 ENOG4108KPJ rna polymerase sigma factor B7R87_RS16055 ENOG4105ZJT Cell division protein CrgA B7R87_RS16065 ENOG4108U4N (sortase) family B7R87_RS16080 ENOG4108U4N (sortase) family B7R87_RS16085 ENOG4108RN7 integral membrane protein B7R87_RS16095 ENOG4105CJN penicillin-binding protein B7R87_RS16100 ENOG4107QHZ cell cycle protein B7R87_RS16110 ENOG4105HZM Fha domain containing protein B7R87_RS16115 ENOG4105TV9 FHA Domain-Containing protein B7R87_RS16125 ENOG4105BZU Histidine kinase B7R87_RS16130 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS16145 ENOG41082J7 Rhodanese domain protein B7R87_RS16155 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) B7R87_RS16160 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit B7R87_RS16165 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit B7R87_RS16170 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit B7R87_RS16175 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit B7R87_RS16220 ENOG4105C7S Dehydrogenase B7R87_RS16225 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) B7R87_RS16295 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) B7R87_RS16310 ENOG4107QPV Serine Threonine protein kinase B7R87_RS16340 ENOG4105CPP Dehydrogenase, E1 component B7R87_RS16345 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 B7R87_RS16385 ENOG4105DFM M18 family aminopeptidase B7R87_RS16400 ENOG4105CSU acyl-Coa dehydrogenase B7R87_RS16410 ENOG4105EUB pirin domain protein B7R87_RS16420 ENOG4108VQR secreted hydrolase B7R87_RS16425 ENOG4105C9M aspartyl-trna synthetase B7R87_RS16525 ENOG4105CIH Imidazole acetol-phosphate transaminase B7R87_RS16545 ENOG41068W2 Cytochrome p-450 B7R87_RS16615 ENOG4106F60 Histidine kinase B7R87_RS16620 ENOG4105F44 Two component transcriptional regulator, winged helix family B7R87_RS16635 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) B7R87_RS16650 ENOG4108UZX fmn reductase B7R87_RS16665 ENOG4105CAT Cytidine monophosphate kinase B7R87_RS16695 ENOG4105D7N magnesium and cobalt transport protein CorA B7R87_RS16710 ENOG4105EB3 Histidine kinase B7R87_RS16725 ENOG4106JDR secreted B7R87_RS16785 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase B7R87_RS16820 ENOG4105D1H recombination factor protein RarA B7R87_RS16840 ENOG4105VT3 DNA binding domain protein, excisionase family B7R87_RS16870 ENOG4105C10 Electron transfer flavoprotein B7R87_RS16900 ENOG4105EYF MMPL domain protein B7R87_RS16905 ENOG4108TEB UPF0114 protein B7R87_RS16930 ENOG4107SCK Monooxygenase B7R87_RS16945 ENOG4105E0A ABC, transporter B7R87_RS16950 ENOG4105J76 Periplasmic binding protein B7R87_RS16955 ENOG4105S6R Iron-hydroxamate transporter permease subunit B7R87_RS17050 ENOG41082YX Transcriptional regulator, arsr family B7R87_RS17070 ENOG4105C57 major facilitator superfamily B7R87_RS17075 ENOG4105DUU IucA IucC family protein B7R87_RS17090 ENOG4105C85 amino acid B7R87_RS17105 ENOG4105DXX methyltransferase B7R87_RS17120 ENOG4106UW1 Major Facilitator superfamily B7R87_RS17185 ENOG4105VEQ Cold shock protein B7R87_RS17200 ENOG4105DHP deoxycytidine triphosphate deaminase B7R87_RS17215 ENOG4105DF6 Fe-S oxidoreductase B7R87_RS17220 ENOG4105D3Q Sugar transferase B7R87_RS17225 ENOG4105CFG Acts as a chaperone (By similarity) B7R87_RS17230 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ B7R87_RS17235 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) B7R87_RS17240 ENOG4105KNI merR family transcriptional Regulator B7R87_RS17265 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit B7R87_RS17295 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) B7R87_RS17310 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) B7R87_RS17315 ENOG4107RCW fructose-bisphosphate aldolase B7R87_RS17340 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS17360 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) B7R87_RS17375 ENOG410905P Pyridoxamine 5-phosphate B7R87_RS17390 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS17395 ENOG4105BZU Histidine kinase B7R87_RS17405 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis B7R87_RS17420 ENOG4105BZ1 (ABC) transporter B7R87_RS17430 ENOG4108HMN Caspase domain B7R87_RS17440 ENOG4108JPW Aminotransferase B7R87_RS17445 ENOG4108V4B ThiJ pfpI B7R87_RS17460 ENOG4108762 serine threonine protein kinase B7R87_RS17520 ENOG4105GFG DUF218 domain B7R87_RS17535 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) B7R87_RS17570 ENOG4105DRR Transcriptional regulator, GntR family B7R87_RS17575 ENOG4105CKK Glycosyl transferase, family 2 B7R87_RS17590 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) B7R87_RS17595 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) B7R87_RS17605 ENOG4105CFH Aspartokinase B7R87_RS17615 ENOG4105NAF rna polymerase sigma factor B7R87_RS17640 ENOG4105DR4 Methyltransferase B7R87_RS17685 ENOG4105CIR epoxide hydrolase B7R87_RS17735 ENOG4105CVR type I restriction-modification system B7R87_RS17745 ENOG4105DZR Type I site-specific deoxyribonuclease B7R87_RS17755 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) B7R87_RS17810 ENOG4107ZVI PhiRv2 prophage protein B7R87_RS17825 ENOG4105ETE Transcriptional regulator (LacI family B7R87_RS17855 ENOG4105BZ4 penicillin-binding protein B7R87_RS17890 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) B7R87_RS17920 ENOG4105D74 hydrolase B7R87_RS17930 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) B7R87_RS17935 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) B7R87_RS17940 ENOG4107B2H carbonic anhydrase B7R87_RS18020 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) B7R87_RS18030 ENOG41086VD Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) B7R87_RS18035 ENOG4108I5C dEAD DEAH box helicase B7R87_RS18040 ENOG4105WN5 stage II sporulation protein B7R87_RS18050 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for B7R87_RS18060 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) B7R87_RS18070 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) B7R87_RS18075 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) B7R87_RS18080 ENOG4105C6E dna polymerase iii B7R87_RS18085 ENOG4106JDR secreted B7R87_RS18110 ENOG4107ZVI PhiRv2 prophage protein B7R87_RS18135 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) B7R87_RS18185 ENOG4105C26 Dehydrogenase B7R87_RS18190 ENOG4108JQ6 ABC transporter B7R87_RS18200 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B7R87_RS18205 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B7R87_RS18210 ENOG4105DEF Extracellular solute-binding protein, family 5 B7R87_RS18245 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B7R87_RS18265 ENOG4105C0X amino acid B7R87_RS18270 ENOG4108Q50 Histidine kinase B7R87_RS18350 ENOG4106NZI LysR family Transcriptional regulator B7R87_RS18385 ENOG4105C0B DNA polymerase III (alpha subunit) B7R87_RS18390 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) B7R87_RS18425 ENOG4105BZ1 (ABC) transporter B7R87_RS18475 ENOG4105ECQ AraC Family Transcriptional Regulator B7R87_RS18480 ENOG4105C2M dna polymerase I B7R87_RS18505 ENOG4105EV4 Multidrug resistance protein mdtH B7R87_RS18525 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) B7R87_RS18570 ENOG4105C26 Dehydrogenase B7R87_RS18600 ENOG4105CVK Glutamate decarboxylase B7R87_RS18605 ENOG41082VC UPF0145 protein B7R87_RS18610 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN B7R87_RS18620 ENOG4105F0N pyrophosphate phospho-hydrolase B7R87_RS18640 ENOG4108UGV hypoxanthine phosphoribosyltransferase B7R87_RS18650 ENOG4105EUJ GTP cyclohydrolase i B7R87_RS18675 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family B7R87_RS18680 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) B7R87_RS18705 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase B7R87_RS18725 ENOG4105CRK lysyL-tRNA synthetase B7R87_RS18735 ENOG4108IJ8 ABC transporter B7R87_RS18740 ENOG4105E90 ABC transporter B7R87_RS18745 ENOG4105E90 ABC transporter B7R87_RS18760 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) B7R87_RS18775 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS18780 ENOG4105I1F Resistance protein B7R87_RS18785 ENOG41082SX arsR family transcriptional regulator B7R87_RS18800 ENOG4105C5W Aldolase B7R87_RS18810 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) B7R87_RS18815 ENOG4108IYU L-aspartate oxidase B7R87_RS18825 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) B7R87_RS18860 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit B7R87_RS18880 ENOG4105DR5 peptidase B7R87_RS18885 ENOG4108FKE two-component system sensor kinase B7R87_RS18890 ENOG4108PYU two-component system response regulator B7R87_RS18900 ENOG4105NAF rna polymerase sigma factor B7R87_RS18905 ENOG4105CEN a g-specific adenine glycosylase B7R87_RS18910 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase B7R87_RS18920 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) B7R87_RS18935 ENOG4108JWX B7R87_RS18940 ENOG4107R33 ppx gppa phosphatase B7R87_RS18945 ENOG4105EY0 Xylose isomerase domain protein TIM barrel B7R87_RS18955 ENOG4105C01 Dihydroxy-acid dehydratase B7R87_RS18960 ENOG4108762 serine threonine protein kinase B7R87_RS18965 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein B7R87_RS18980 ENOG4108KPJ rna polymerase sigma factor B7R87_RS18990 ENOG4105CJ1 ABC, transporter B7R87_RS19000 ENOG4105II7 pyrroline-5-carboxylate reductase B7R87_RS19005 ENOG4105C31 Tryptophanyl-tRNA synthetase B7R87_RS19025 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 B7R87_RS19070 ENOG4108RXW HAD-superfamily subfamily IB hydrolase B7R87_RS19080 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) B7R87_RS19085 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) B7R87_RS19090 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) B7R87_RS19095 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) B7R87_RS19110 ENOG4105D52 delta-aminolevulinic acid dehydratase B7R87_RS19155 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase B7R87_RS19180 ENOG4105C75 arginyL-tRNA synthetase B7R87_RS19185 ENOG4105DK7 lysyl-tRNA synthetase B7R87_RS19225 ENOG4105E0Y RtcB Protein B7R87_RS19235 ENOG4105KK4 UPF0060 membrane protein B7R87_RS19275 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) B7R87_RS19295 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase B7R87_RS19300 ENOG4108RH7 phosphoglycerate mutase B7R87_RS19320 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) B7R87_RS19325 ENOG4105CRE cytochrome C B7R87_RS19350 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) B7R87_RS19355 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase B7R87_RS19365 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) B7R87_RS19380 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase B7R87_RS19390 ENOG4105DVY radical SAM domain protein B7R87_RS19405 ENOG4107QJT sodium dicarboxylate symporter B7R87_RS19430 ENOG4105VEQ Cold shock protein B7R87_RS19435 ENOG4105EV6 Pfam:DUF178 B7R87_RS19445 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) B7R87_RS19455 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) B7R87_RS19485 ENOG4108R85 Short chain dehydrogenase B7R87_RS19500 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) B7R87_RS19505 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain B7R87_RS19510 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) B7R87_RS19520 ENOG4107QIZ NADH dehydrogenase B7R87_RS19525 ENOG4108IEH NADH dehydrogenase subunit g B7R87_RS19530 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) B7R87_RS19535 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) B7R87_RS19540 ENOG41087XN oxidoreductase B7R87_RS19545 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) B7R87_RS19550 ENOG4105D65 subunit l B7R87_RS19560 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) B7R87_RS19565 ENOG4105ERH Fumarylacetoacetate hydrolase B7R87_RS19600 ENOG4105IIU Aminopeptidase B7R87_RS19615 ENOG4105KVH Transcriptional regulator B7R87_RS19640 ENOG4105DQU oxidoreductase, subunit beta B7R87_RS19645 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein B7R87_RS19665 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain B7R87_RS19670 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) B7R87_RS19680 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) B7R87_RS19685 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) B7R87_RS19690 ENOG4107YX3 NADH dehydrogenase subunit j B7R87_RS19695 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) B7R87_RS19705 ENOG4105C8S subunit m B7R87_RS19710 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) B7R87_RS19715 ENOG4105D0M Protease HtpX homolog B7R87_RS19720 ENOG410901E Membrane B7R87_RS19730 ENOG4105CF1 Alkylated DNA repair protein B7R87_RS19735 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) B7R87_RS19740 ENOG4108VPT UPF0234 protein B7R87_RS19825 ENOG4105GFG DUF218 domain B7R87_RS19855 ENOG4105WDJ 50S ribosomal protein L33 B7R87_RS19860 ENOG410900P UPF0336 protein B7R87_RS19880 ENOG4107R4N Cell wall formation (By similarity) B7R87_RS19905 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) B7R87_RS19910 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) B7R87_RS19915 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) B7R87_RS19920 ENOG4105QCJ Lipoprotein B7R87_RS19925 ENOG4108VZM 50s ribosomal protein L10 B7R87_RS19935 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) B7R87_RS19940 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) B7R87_RS20040 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) B7R87_RS20050 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) B7R87_RS20055 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) B7R87_RS20080 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) B7R87_RS20085 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) B7R87_RS20090 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) B7R87_RS20095 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) B7R87_RS20100 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity B7R87_RS20105 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) B7R87_RS20110 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) B7R87_RS20115 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) B7R87_RS20120 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) B7R87_RS20125 ENOG41082SA 50s ribosomal protein l29 B7R87_RS20130 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal B7R87_RS20135 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) B7R87_RS20140 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) B7R87_RS20145 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits B7R87_RS20150 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) B7R87_RS20160 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) B7R87_RS20165 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) B7R87_RS20170 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) B7R87_RS20175 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) B7R87_RS20180 ENOG410849U 50S ribosomal protein L30 B7R87_RS20185 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) B7R87_RS20190 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) B7R87_RS20195 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) B7R87_RS20205 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) B7R87_RS20215 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits B7R87_RS20220 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) B7R87_RS20225 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) B7R87_RS20230 ENOG4108ZT0 50S ribosomal protein l17 B7R87_RS20235 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) B7R87_RS20245 ENOG4105C5H ABC transporter B7R87_RS20250 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) B7R87_RS20255 ENOG4108UJD 30S ribosomal protein S9 B7R87_RS20260 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) B7R87_RS20275 ENOG4105YVS arsR family transcriptional regulator B7R87_RS20305 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) B7R87_RS20330 ENOG4105CS9 pantothenic acid kinase B7R87_RS20335 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) B7R87_RS20360 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) B7R87_RS20365 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 B7R87_RS20370 ENOG4108097 ATP-binding protein B7R87_RS20395 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) B7R87_RS20410 ENOG4105CHP RNA polymerase B7R87_RS20440 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) B7R87_RS20445 ENOG4108JQ1 Dehydrogenase B7R87_RS20450 ENOG4105EMU Dehydrogenase B7R87_RS20460 ENOG4105DND Transcriptional regulator B7R87_RS20465 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) B7R87_RS20470 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS20475 ENOG4108MMM RNA Polymerase B7R87_RS20485 ENOG4107QVP Dehydrogenase B7R87_RS20495 ENOG4107QQG Dehydrogenase B7R87_RS20500 ENOG4105C6V Glycerol-3-phosphate dehydrogenase B7R87_RS20520 ENOG4105C26 Dehydrogenase B7R87_RS20540 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) B7R87_RS20570 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS20590 ENOG4105DR5 peptidase B7R87_RS20615 ENOG4105KKX ATPase associated with various cellular activities aaa_5 B7R87_RS20620 ENOG4105RD5 B7R87_RS20625 ENOG4105DEG Vwa containing coxe family protein B7R87_RS20630 ENOG4105CMV Succinyl-CoA synthetase subunit beta B7R87_RS20660 ENOG4105DC1 bifunctional purine biosynthesis protein purh B7R87_RS20670 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) B7R87_RS20685 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) B7R87_RS20690 ENOG4105EMU Dehydrogenase B7R87_RS20700 ENOG4105C8Y Acetylornithine aminotransferase B7R87_RS20705 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) B7R87_RS20720 ENOG4105EMN RNA polymerase sigma factor B7R87_RS20725 ENOG4105C31 Tryptophanyl-tRNA synthetase B7R87_RS20770 ENOG4107RN3 metallophosphoesterase B7R87_RS20775 ENOG4105BZU Histidine kinase B7R87_RS20780 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7R87_RS20785 ENOG4105EYF MMPL domain protein B7R87_RS20790 ENOG41067SE Tetr family transcriptional regulator B7R87_RS20820 ENOG4108J01 L-aspartate oxidase B7R87_RS20840 ENOG4105E2D ec 3.2.1.52 B7R87_RS20885 ENOG4108MMM RNA Polymerase B7R87_RS20905 ENOG4108NIW Leucine export protein LeuE B7R87_RS20930 ENOG4107RM1 amidohydrolase B7R87_RS20935 ENOG4105DIH basic membrane B7R87_RS20940 ENOG4108JQ9 ABC transporter B7R87_RS20945 ENOG4105UIB (ABC) transporter B7R87_RS20980 ENOG4105D94 Major Facilitator Superfamily B7R87_RS20985 ENOG4107RSM transcriptional regulator B7R87_RS20995 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) B7R87_RS21020 ENOG41065SU Two-component system sensor kinase B7R87_RS21025 ENOG4108KXV response regulator B7R87_RS21030 ENOG4105NAF rna polymerase sigma factor B7R87_RS21035 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) B7R87_RS21040 ENOG4105C26 Dehydrogenase B7R87_RS21045 ENOG4105C26 Dehydrogenase B7R87_RS21080 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain B7R87_RS21105 ENOG4108JIK carboxylase B7R87_RS21110 ENOG4107WR6 Maf-like protein B7R87_RS21120 ENOG4105D8K carboxyl transferase B7R87_RS21130 ENOG4108QER Adenylate cyclase B7R87_RS21135 ENOG4105E39 Enoyl-CoA hydratase B7R87_RS21140 ENOG4105KDM Diguanylate cyclase with gaf sensor B7R87_RS21145 ENOG4105C84 Histidine ammonia-lyase B7R87_RS21155 ENOG4107UBC ErfK ybiS ycfS ynhG family protein B7R87_RS21180 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) B7R87_RS21205 ENOG4105NAF rna polymerase sigma factor B7R87_RS21215 ENOG4105C7B Threonine dehydratase B7R87_RS21235 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) B7R87_RS21245 ENOG4105T1M mycothiol conjugate amidase mca B7R87_RS21260 ENOG4105C7Z Conserved Protein B7R87_RS21290 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) B7R87_RS21355 ENOG4105D3Q Sugar transferase B7R87_RS21375 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) B7R87_RS21465 ENOG4108FUF Transcriptional regulator, IclR family B7R87_RS21470 ENOG4105KME endoribonuclease L-psp B7R87_RS21475 ENOG4105C6Z Gluconate B7R87_RS21480 ENOG4105EQK -acetyltransferase B7R87_RS21545 ENOG4105DND Transcriptional regulator B7R87_RS21555 ENOG4105Q56 cytochrome P450 B7R87_RS21580 ENOG4105DHQ Histidine kinase B7R87_RS21655 ENOG4107QKZ Ompa motb domain protein B7R87_RS21715 ENOG4105DVW rieske (2Fe-2S) B7R87_RS21745 ENOG4105C1G acyl-Coa dehydrogenase B7R87_RS21760 ENOG4105MC2 DSBA oxidoreductase B7R87_RS21780 ENOG4105CZS beta-ketoacyl synthase B7R87_RS21805 ENOG4105Q56 cytochrome P450 B7R87_RS21810 ENOG4108M15 ABC transporter B7R87_RS21820 ENOG4105VZ8 Transcriptional regulator B7R87_RS21865 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase B7R87_RS21895 ENOG4105KVH Transcriptional regulator B7R87_RS21900 ENOG4105CPC Aldo Keto reductase B7R87_RS21905 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) B7R87_RS21910 ENOG4108IAB Phoh family B7R87_RS21930 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) B7R87_RS21935 ENOG4105D3R alkyl hydroperoxide reductase B7R87_RS21945 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) B7R87_RS21980 ENOG4105BZ4 penicillin-binding protein B7R87_RS21985 ENOG4105CH6 catalase B7R87_RS22000 ENOG4105C9Q fumarate hydratase class II B7R87_RS22010 ENOG4107GFK fumarate B7R87_RS22040 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) B7R87_RS22045 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) B7R87_RS22050 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) B7R87_RS22055 ENOG4105CUB amino acid B7R87_RS22060 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) B7R87_RS22075 ENOG4105C3G gtp-binding protein B7R87_RS22130 ENOG41087YS Phage shock protein A B7R87_RS22145 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) B7R87_RS22165 ENOG4105CI3 gtp-binding protein typa B7R87_RS22170 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B7R87_RS22175 ENOG4108J59 Extracellular solute-binding protein, family 5 B7R87_RS22190 ENOG4108JQ7 (ABC) transporter B7R87_RS22205 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B7R87_RS22210 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B7R87_RS22215 ENOG4105C3U ABC transporter B7R87_RS22220 ENOG4108JQ7 (ABC) transporter B7R87_RS22235 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) B7R87_RS22260 ENOG4108Z4U Ferredoxin B7R87_RS22280 ENOG4107R4C succinyl-diaminopimelate desuccinylase B7R87_RS22285 ENOG4108URH decarboxylase B7R87_RS22290 ENOG4105EEI dihydropteroate synthase B7R87_RS22300 ENOG4108R3E Dna-3-methyladenine glycosylase i B7R87_RS22305 ENOG4108UKI Enoyl-CoA hydratase B7R87_RS22320 ENOG4105DU6 RNA polymerase B7R87_RS22330 ENOG4105C0H protease B7R87_RS22335 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) B7R87_RS22370 ENOG4105D7N magnesium and cobalt transport protein CorA B7R87_RS22395 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein B7R87_RS22405 ENOG4105C1J atp-dependent rna helicase B7R87_RS22495 ENOG4105C4R Atp-dependent dna helicase B7R87_RS22500 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) B7R87_RS22525 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) B7R87_RS22595 ENOG41063PX domain protein B7R87_RS22605 ENOG4105DJZ UPF0182 protein B7R87_RS22645 ENOG4107TK4 histidinol-phosphate phosphatase B7R87_RS22650 ENOG4105KPY Small multidrug resistance protein B7R87_RS22660 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase B7R87_RS22670 ENOG4108RAV Conserved protein B7R87_RS22680 ENOG4105EMN RNA polymerase sigma factor B7R87_RS22685 ENOG4105WMN AntiSigma factor B7R87_RS22690 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase B7R87_RS22705 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) B7R87_RS22710 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B7R87_RS22715 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B7R87_RS22720 ENOG4105FDP GntR family transcriptional regulator B7R87_RS22730 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component B7R87_RS22735 ENOG4105DRS transport system, permease B7R87_RS22740 ENOG4105D17 glycoside hydrolase, family 3 domain protein B7R87_RS22745 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) B7R87_RS22760 ENOG4105CBD Diacylglycerol kinase B7R87_RS22815 ENOG4108KXM LysR family Transcriptional regulator B7R87_RS22830 ENOG4108VEQ Superoxide dismutase B7R87_RS22845 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) B7R87_RS22850 ENOG4105NAF rna polymerase sigma factor B7R87_RS22865 ENOG4105E5Q amino acid AbC transporter B7R87_RS22870 ENOG4107RP9 extracellular solute-binding protein, family 3 B7R87_RS22885 ENOG4105CB2 alcohol dehydrogenase B7R87_RS22935 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) B7R87_RS22945 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 B7R87_RS22950 ENOG4105EB3 Histidine kinase B7R87_RS22955 ENOG4108PYU two-component system response regulator B7R87_RS23000 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) B7R87_RS23005 ENOG4105DDN Pentapeptide repeat-containing protein B7R87_RS23080 ENOG4105CJN penicillin-binding protein B7R87_RS23090 ENOG4108FKE two-component system sensor kinase B7R87_RS23120 ENOG4105DQE DNA ligase B7R87_RS23125 ENOG4105FDF Could be involved in DNA repair (By similarity) B7R87_RS23160 ENOG4105DRR Transcriptional regulator, GntR family B7R87_RS23215 ENOG4105ETX regulatoR B7R87_RS23220 ENOG4105C75 arginyL-tRNA synthetase B7R87_RS23225 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) B7R87_RS23230 ENOG4105D6E homoserine dehydrogenase B7R87_RS23235 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) B7R87_RS23240 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) B7R87_RS23250 ENOG4108KGH TRANSCRIPTIONal B7R87_RS23255 ENOG4105VFB Binds the 23S rRNA (By similarity) B7R87_RS23260 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) B7R87_RS23265 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) B7R87_RS23275 ENOG4107ZF2 Phosphatase B7R87_RS23280 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) B7R87_RS23290 ENOG4105Z3P ATP synthase B7R87_RS23300 ENOG4105ZA1 atp synthase B7R87_RS23305 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) B7R87_RS23310 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) B7R87_RS23315 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) B7R87_RS23320 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) B7R87_RS23325 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) B7R87_RS23330 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) B7R87_RS23345 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS23350 ENOG4105BZU Histidine kinase B7R87_RS23365 ENOG410630P Transcriptional regulator B7R87_RS23370 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase B7R87_RS23385 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) B7R87_RS23415 ENOG4105CJ1 ABC, transporter B7R87_RS23445 ENOG4105CHU acetyl-coa acetyltransferase B7R87_RS23465 ENOG4105ETX regulatoR B7R87_RS23470 ENOG4106F60 Histidine kinase B7R87_RS23505 ENOG4105WX6 Membrane B7R87_RS23540 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) B7R87_RS23545 ENOG4105C6K Malic enzyme B7R87_RS23550 ENOG4105CTQ phosphohexokinase B7R87_RS23560 ENOG4108MRH transcriptional regulatory protein B7R87_RS23565 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism B7R87_RS23570 ENOG4107QJT sodium dicarboxylate symporter B7R87_RS23580 ENOG4108Z6Z Transcriptional regulator B7R87_RS23595 ENOG4108JU3 Alkyl hydroperoxide reductase B7R87_RS23610 ENOG4105CG3 alpha amylase, catalytic region B7R87_RS23615 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) B7R87_RS23630 ENOG4105EFA 4-hydroxyphenylacetate B7R87_RS23640 ENOG41061H0 Monooxygenase B7R87_RS23645 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) B7R87_RS23650 ENOG4105BZU Histidine kinase B7R87_RS23655 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS23665 ENOG4105BZ1 (ABC) transporter B7R87_RS23670 ENOG4105BZ1 (ABC) transporter B7R87_RS23755 ENOG4105DEN Luciferase family B7R87_RS23760 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase B7R87_RS23785 ENOG4105EJQ L-serine dehydratase B7R87_RS23795 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) B7R87_RS23835 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) B7R87_RS23855 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) B7R87_RS23995 ENOG4105CDU Replicative dna helicase B7R87_RS24025 ENOG4105EKQ RNA-directed DNA polymerase B7R87_RS24080 ENOG4107SN7 NLP P60 protein B7R87_RS24085 ENOG4105CEC DNA methylase N-4 N-6 B7R87_RS24120 ENOG4105EJQ L-serine dehydratase B7R87_RS24125 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) B7R87_RS24130 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) B7R87_RS24135 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) B7R87_RS24155 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B7R87_RS24175 ENOG4108JQ7 (ABC) transporter B7R87_RS24180 ENOG4105EN6 Membrane B7R87_RS24200 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) B7R87_RS24210 ENOG4108URH decarboxylase B7R87_RS24225 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) B7R87_RS24230 ENOG4105BZU Histidine kinase B7R87_RS24235 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) B7R87_RS24240 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) B7R87_RS24250 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) B7R87_RS24260 ENOG4105EYF MMPL domain protein B7R87_RS24265 ENOG4105D9U N-acetyltransferase B7R87_RS24280 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS24290 ENOG4105D8V Glucose sorbosone dehydrogenase B7R87_RS24295 ENOG4105CPC Aldo Keto reductase B7R87_RS24305 ENOG4105BZU Histidine kinase B7R87_RS24315 ENOG4108ZP8 Acetolactate synthase small subunit B7R87_RS24320 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase B7R87_RS24325 ENOG4108JQ1 Dehydrogenase B7R87_RS24330 ENOG4105C57 major facilitator superfamily B7R87_RS24340 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR B7R87_RS24350 ENOG4105C26 Dehydrogenase B7R87_RS24365 ENOG4105ECQ AraC Family Transcriptional Regulator B7R87_RS24370 ENOG41082W1 Cupin 2, conserved barrel domain protein B7R87_RS24380 ENOG4105NPE arsR family transcriptional regulator B7R87_RS24395 ENOG4105KNE Phosphatidate cytidylyltransferase B7R87_RS24410 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) B7R87_RS24415 ENOG4105CM2 brancheD-chain amino acid aminotransferase B7R87_RS24430 ENOG4105CQM Urea amidohydrolase subunit alpha B7R87_RS24435 ENOG4105DWY Agmatine deiminase B7R87_RS24450 ENOG4105CSH Transporter B7R87_RS24455 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) B7R87_RS24475 ENOG4108YYC ycei family B7R87_RS24480 ENOG4106AM8 polysaccharide lyase family 8 B7R87_RS24485 ENOG4105D8K carboxyl transferase B7R87_RS24505 ENOG4105GWZ Roadblock lc7 family protein B7R87_RS24525 ENOG4105GWZ Roadblock lc7 family protein B7R87_RS24535 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase B7R87_RS24540 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) B7R87_RS24575 ENOG41069M3 Transcriptional regulator B7R87_RS24580 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) B7R87_RS24585 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) B7R87_RS24595 ENOG4105K70 DNA-binding protein B7R87_RS24605 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) B7R87_RS24615 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase B7R87_RS24620 ENOG4105CPF Cell wall formation (By similarity) B7R87_RS24640 ENOG4105DWF phosphomethylpyrimidine kinase B7R87_RS24645 ENOG4105VB9 50S ribosomal protein l28 B7R87_RS24650 ENOG4105DP4 dak2 domain fusion protein ylov B7R87_RS24660 ENOG4106H78 methyltransferase B7R87_RS24665 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) B7R87_RS24680 ENOG41084BZ 50S ribosomal protein L32 B7R87_RS24685 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) B7R87_RS24690 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) B7R87_RS24700 ENOG4108375 Acylphosphatase (EC 3.6.1.7) B7R87_RS24710 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) B7R87_RS24760 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) B7R87_RS24770 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) B7R87_RS24780 ENOG4105K5M 30s ribosomal protein S16 B7R87_RS24785 ENOG41082KU UPF0109 protein B7R87_RS24790 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) B7R87_RS24795 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) B7R87_RS24800 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) B7R87_RS24810 ENOG4107QYR Signal peptidase i B7R87_RS24820 ENOG4107QYR Signal peptidase i B7R87_RS24835 ENOG41080R2 UPF0102 protein B7R87_RS24840 ENOG4105C0P Mg chelatase subunit ChlI B7R87_RS24850 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B7R87_RS24865 ENOG4105CE9 30S ribosomal protein S2 B7R87_RS24870 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) B7R87_RS24875 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) B7R87_RS24880 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) B7R87_RS24885 ENOG4105KNE Phosphatidate cytidylyltransferase B7R87_RS24890 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs B7R87_RS24900 ENOG4108I5D sulfate abc transporter B7R87_RS24905 ENOG4108UCS ABC, transporter B7R87_RS24920 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) B7R87_RS24925 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) B7R87_RS24935 ENOG4105C26 Dehydrogenase B7R87_RS24945 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS24950 ENOG4105BZU Histidine kinase B7R87_RS24965 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) B7R87_RS24975 ENOG4105C26 Dehydrogenase B7R87_RS24985 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) B7R87_RS24990 ENOG4105F38 ABC transporter, permease B7R87_RS24995 ENOG4105D38 putrescine abc transporter B7R87_RS25000 ENOG4105CJP fad dependent oxidoreductase B7R87_RS25030 ENOG4105G9B Transcriptional regulator B7R87_RS25050 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) B7R87_RS25055 ENOG4105DZP Membrane-associated zinc metalloprotease B7R87_RS25060 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) B7R87_RS25075 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) B7R87_RS25095 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) B7R87_RS25110 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) B7R87_RS25120 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) B7R87_RS25125 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) B7R87_RS25140 ENOG4105C3U ABC transporter B7R87_RS25145 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B7R87_RS25155 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein B7R87_RS25185 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin B7R87_RS25200 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin B7R87_RS25230 ENOG4105EC2 ftsk spoIIIe B7R87_RS25240 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) B7R87_RS25245 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) B7R87_RS25250 ENOG4105C1V Peptidase, M16 B7R87_RS25255 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) B7R87_RS25280 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) B7R87_RS25285 ENOG4105CN5 Metallo-Beta-Lactamase B7R87_RS25315 ENOG4105BZU Histidine kinase B7R87_RS25320 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase B7R87_RS25325 ENOG4107QZI cell division protein FtsK B7R87_RS25345 ENOG4105CEV competence damage-inducible protein B7R87_RS25350 ENOG4105WBV Transcriptional regulator B7R87_RS25365 ENOG41061TZ Short-chain dehydrogenase reductase Sdr B7R87_RS25370 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) B7R87_RS25375 ENOG4107QRT dEAD DEAH box helicase B7R87_RS25400 ENOG4105DSF transport protein B7R87_RS25410 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) B7R87_RS25415 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) B7R87_RS25440 ENOG4105DRP amino acid AbC transporter B7R87_RS25445 ENOG4108Q1T ABC transporter B7R87_RS25450 ENOG4107UBR Extracellular solute-binding protein family 3 B7R87_RS25455 ENOG4105CDA abc transporter atp-binding protein B7R87_RS25460 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7R87_RS25465 ENOG4105EB3 Histidine kinase B7R87_RS25475 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) B7R87_RS25495 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) B7R87_RS25505 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) B7R87_RS25510 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) B7R87_RS25520 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) B7R87_RS25540 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) B7R87_RS25545 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) B7R87_RS25550 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B7R87_RS25585 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) B7R87_RS25600 ENOG4105C9U ATP-dependent DNA helicase RecQ B7R87_RS25620 ENOG4105C6F GntR Family Transcriptional Regulator B7R87_RS25625 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B7R87_RS25640 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) B7R87_RS25645 ENOG4105BZU Histidine kinase B7R87_RS25650 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS25655 ENOG4108MRH transcriptional regulatory protein B7R87_RS25660 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism B7R87_RS25670 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) B7R87_RS25685 ENOG4105E4C Lytic transglycosylase catalytic B7R87_RS25690 ENOG4105DRR Transcriptional regulator, GntR family B7R87_RS25695 ENOG410849S phosphocarrier protein (HPr) B7R87_RS25700 ENOG4105CD5 CoA-binding domain protein B7R87_RS25700 ENOG4105CD5 CoA-binding domain protein B7R87_RS25715 ENOG4107W53 thymidine kinase B7R87_RS25785 ENOG4105EC2 ftsk spoIIIe B7R87_RS25820 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) B7R87_RS25875 ENOG4105CM4 permease protein B7R87_RS25880 ENOG4108IPW abc transporter atp-binding protein B7R87_RS25885 ENOG4105DJB Major Facilitator Superfamily B7R87_RS25890 ENOG4105CHU acetyl-coa acetyltransferase B7R87_RS25900 ENOG4105CHU acetyl-coa acetyltransferase B7R87_RS25905 ENOG4105C29 acyl-CoA thioesterase B7R87_RS25910 ENOG410846T CoA-transferase family III B7R87_RS25930 ENOG410900P UPF0336 protein B7R87_RS25960 ENOG41067TZ transcriptional regulator, MarR family B7R87_RS25995 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) B7R87_RS26000 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase B7R87_RS26025 ENOG4105BZ1 (ABC) transporter B7R87_RS26055 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase B7R87_RS26065 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase B7R87_RS26080 ENOG41061H0 Monooxygenase B7R87_RS26100 ENOG4105RNG membrane B7R87_RS26105 ENOG4106JDR secreted B7R87_RS26135 ENOG4107XSR periplasmic solute binding protein B7R87_RS26145 ENOG4105CC5 ABC transporter B7R87_RS26150 ENOG4105E0A ABC, transporter B7R87_RS26205 ENOG41060M0 Crispr-associated protein, cse4 family B7R87_RS26210 ENOG4108VWQ crispr-associated protein B7R87_RS26220 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) B7R87_RS26225 ENOG4105PWE CRISPR-associated protein cas2 B7R87_RS26415 ENOG4105ZXU NLP P60 protein B7R87_RS26640 ENOG4108KQ5 Integrase catalytic subunit B7R87_RS26670 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) B7R87_RS26690 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) B7R87_RS26695 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) B7R87_RS26750 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) B7R87_RS26755 ENOG4105C0X amino acid B7R87_RS26760 ENOG4107VEG TrkA-N domain protein B7R87_RS26770 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) B7R87_RS26805 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) B7R87_RS26815 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) B7R87_RS26840 ENOG4106F60 Histidine kinase B7R87_RS26845 ENOG4105F44 Two component transcriptional regulator, winged helix family B7R87_RS26855 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) B7R87_RS26920 ENOG4107QK5 Homocysteine s-methyltransferase B7R87_RS26930 ENOG4107S1Q Phosphatase B7R87_RS26935 ENOG4105CEU Arginine dihydrolase B7R87_RS26940 ENOG4105DBV ornithine carbamoyltransferase B7R87_RS26945 ENOG4105CGU Enoyl-CoA hydratase B7R87_RS26995 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) B7R87_RS27035 ENOG4105MXW flavin reductase domain protein, FMN-binding B7R87_RS27045 ENOG4108RVA ribokinase B7R87_RS27055 ENOG4105BZU Histidine kinase B7R87_RS27060 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS27065 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) B7R87_RS27070 ENOG4107RBB ABC transporter, permease B7R87_RS27075 ENOG4105ENX hydrolase B7R87_RS27085 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) B7R87_RS27095 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase B7R87_RS27100 ENOG4107QM5 aconitate hydratase B7R87_RS27115 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component B7R87_RS27125 ENOG4105E2R ROK family B7R87_RS27130 ENOG4105DFW ABC transporter B7R87_RS27135 ENOG4105C2J ABC transporter B7R87_RS27140 ENOG4107RNG ABC transporter B7R87_RS27145 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) B7R87_RS27150 ENOG4105CUB amino acid B7R87_RS27160 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase B7R87_RS27165 ENOG4105CHU acetyl-coa acetyltransferase B7R87_RS27170 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) B7R87_RS27185 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) B7R87_RS27190 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase B7R87_RS27200 ENOG4105C1Q protoporphyrinogen oxidase B7R87_RS27205 ENOG4107JTW chlorite dismutase B7R87_RS27235 ENOG4105E18 UPF0276 protein B7R87_RS27290 ENOG4105DFU Cell wall formation (By similarity) B7R87_RS27295 ENOG4105E0X reductase B7R87_RS27365 ENOG4107WA4 MmpL domain-containing protein B7R87_RS27385 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component B7R87_RS27390 ENOG4108IY8 ABC, transporter B7R87_RS27395 ENOG4107UWC ABC, transporter B7R87_RS27410 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) B7R87_RS27415 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) B7R87_RS27425 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) B7R87_RS27435 ENOG4107RR1 TRANSCRIPTIONal B7R87_RS27440 ENOG4105CSU acyl-Coa dehydrogenase B7R87_RS27480 ENOG4105EMN RNA polymerase sigma factor B7R87_RS27525 ENOG4108PDG Beta-ketoacyl synthase B7R87_RS27530 ENOG41079R3 acyl carrier protein B7R87_RS27540 ENOG4105KTE polyketide synthesis cyclase B7R87_RS27555 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase B7R87_RS27570 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) B7R87_RS27590 ENOG4105C7K acetolactate synthase B7R87_RS27610 ENOG4105DRR Transcriptional regulator, GntR family B7R87_RS27620 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) B7R87_RS27625 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component B7R87_RS27630 ENOG4107QKW extracellular solute-binding protein family 1 B7R87_RS27650 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding B7R87_RS27680 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) B7R87_RS27690 ENOG4105F44 Two component transcriptional regulator, winged helix family B7R87_RS27695 ENOG4106F60 Histidine kinase B7R87_RS27700 ENOG4105JZI cytochrome P450 B7R87_RS27705 ENOG4108X7A Terpene synthase metal-binding domain-containing protein B7R87_RS27795 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase B7R87_RS27815 ENOG41081F0 Precorrin-8x methylmutase B7R87_RS27820 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) B7R87_RS27825 ENOG4105CTK cobaltochelatase, cobn subunit B7R87_RS27875 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) B7R87_RS27880 ENOG4105CEY Amp-dependent synthetase and ligase B7R87_RS27885 ENOG4105XYF acetyltransferase B7R87_RS27895 ENOG41060W2 glyoxylate carboligase B7R87_RS27905 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase B7R87_RS27910 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) B7R87_RS27930 ENOG4105VT2 5-hydroxyisourate hydrolase B7R87_RS27940 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) B7R87_RS27960 ENOG4105BZ1 (ABC) transporter B7R87_RS27965 ENOG4105BZ1 (ABC) transporter B7R87_RS27970 ENOG4108HUF Transporter B7R87_RS27975 ENOG4105DQ5 transport system permease protein B7R87_RS27980 ENOG4105TVJ transport system, permease B7R87_RS27985 ENOG4105E0A ABC, transporter B7R87_RS28010 ENOG4107R9S Malate synthase B7R87_RS28030 ENOG4107HP6 Transcriptional regulator B7R87_RS28055 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS28065 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) B7R87_RS28070 ENOG4105FDP GntR family transcriptional regulator B7R87_RS28080 ENOG4105CNN ABC, transporter B7R87_RS28085 ENOG4105C2J ABC transporter B7R87_RS28090 ENOG4105DKQ ROK family B7R87_RS28100 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase B7R87_RS28120 ENOG4105CDA abc transporter atp-binding protein B7R87_RS28125 ENOG4107UBR Extracellular solute-binding protein family 3 B7R87_RS28130 ENOG4105EAD ABC transporter B7R87_RS28135 ENOG4105DRP amino acid AbC transporter B7R87_RS28140 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) B7R87_RS28175 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) B7R87_RS28185 ENOG4107S5I aldo keto reductase B7R87_RS28250 ENOG4105C02 permease B7R87_RS28265 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) B7R87_RS28275 ENOG4105ECY inositol monophosphatase B7R87_RS28285 ENOG4108UVJ appr-1-p processing domain protein B7R87_RS28310 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) B7R87_RS28320 ENOG4105BZW Glycerate kinase B7R87_RS28330 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme B7R87_RS28335 ENOG4105C1G acyl-Coa dehydrogenase B7R87_RS28345 ENOG4105CI0 Citrate lyase B7R87_RS28350 ENOG4105RFZ Methylmalonyl-coA mutase B7R87_RS28355 ENOG4105EE1 crotonyl-CoA reductase B7R87_RS28420 ENOG4108ME1 Peptidase M55 D-aminopeptidase B7R87_RS28425 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) B7R87_RS28435 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A B7R87_RS28440 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) B7R87_RS28465 ENOG4107HQ7 repeat protein B7R87_RS28495 ENOG4107WCI zn-dependent hydrolase of the beta-lactamase fold-like protein B7R87_RS28530 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) B7R87_RS28545 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) B7R87_RS28555 ENOG4105CV8 reductase B7R87_RS28570 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) B7R87_RS28575 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) B7R87_RS28590 ENOG4105C2J ABC transporter B7R87_RS28595 ENOG4105CNN ABC, transporter B7R87_RS28600 ENOG4105DFW ABC transporter B7R87_RS28700 ENOG4105CPQ Dehydrogenase B7R87_RS28705 ENOG4105JZI cytochrome P450 B7R87_RS28760 ENOG4105C3J Cysteine desulfurase B7R87_RS28765 ENOG41061TZ Short-chain dehydrogenase reductase Sdr B7R87_RS28785 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein B7R87_RS28815 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) B7R87_RS28820 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) B7R87_RS28825 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) B7R87_RS28830 ENOG4105BZ1 (ABC) transporter B7R87_RS28835 ENOG4105BZ1 (ABC) transporter B7R87_RS28855 ENOG4105K5B UPF0225 protein B7R87_RS28865 ENOG4107YXZ hydrolase, family 25 B7R87_RS28915 ENOG4105DKQ ROK family B7R87_RS28920 ENOG4105C93 Xylose Isomerase B7R87_RS28935 ENOG4105DQE DNA ligase B7R87_RS28960 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) B7R87_RS28970 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) B7R87_RS28975 ENOG4105C5H ABC transporter B7R87_RS28980 ENOG4105KF0 sporulation and cell division protein, SsgA B7R87_RS28990 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) B7R87_RS29000 ENOG4105CHU acetyl-coa acetyltransferase B7R87_RS29005 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase B7R87_RS29030 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) B7R87_RS29045 ENOG4105C94 Transporter B7R87_RS29055 ENOG4105BZM domain protein B7R87_RS29060 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F B7R87_RS29100 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) B7R87_RS29125 ENOG4108MDK Dehydrogenase B7R87_RS29140 ENOG4105FBD synthase B7R87_RS29150 ENOG4107S11 squalene-associated FAD-dependent desaturase B7R87_RS29160 ENOG4105EWU Squalene--hopene cyclase B7R87_RS29195 ENOG4105DR5 peptidase B7R87_RS29200 ENOG41090WU lipolytic protein G-D-S-L family B7R87_RS29210 ENOG4105D4P Coproporphyrinogen iii oxidase B7R87_RS29265 ENOG4105D82 Glutamate dehydrogenase B7R87_RS29335 ENOG4105E4C Lytic transglycosylase catalytic B7R87_RS29395 ENOG4108Z6Z Transcriptional regulator B7R87_RS29400 ENOG4108VVK transcriptional Regulator, AsnC B7R87_RS29410 ENOG4105F38 ABC transporter, permease B7R87_RS29415 ENOG4105D38 putrescine abc transporter B7R87_RS29420 ENOG4107RUE extracellular solute-binding protein family 1 B7R87_RS29425 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) B7R87_RS29430 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase B7R87_RS29435 ENOG4105JSC dimethylmenaquinone methyltransferase B7R87_RS29475 ENOG4107Z6X Transcriptional regulator B7R87_RS29485 ENOG4105EE1 crotonyl-CoA reductase B7R87_RS29500 ENOG4105CPT Alpha beta hydrolase B7R87_RS29560 ENOG4106NMR serine protease B7R87_RS29570 ENOG41061MV Arylsulfatase B7R87_RS29580 ENOG4108RJ7 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity) B7R87_RS29590 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase B7R87_RS29595 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) B7R87_RS29600 ENOG4107TK4 histidinol-phosphate phosphatase B7R87_RS29640 ENOG4105W49 UPF0434 protein B7R87_RS29660 ENOG41073B4 coagulation factor 5 8 type domain-containing protein B7R87_RS29690 ENOG4105E0A ABC, transporter B7R87_RS29695 ENOG4105TVJ transport system, permease B7R87_RS29700 ENOG4105DQ5 transport system permease protein B7R87_RS29705 ENOG4108MES Periplasmic binding protein B7R87_RS29740 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap B7R87_RS29775 ENOG4105EVZ LysR family transcriptional regulator B7R87_RS29780 ENOG4106R7G Glycoside hydrolase family 5 B7R87_RS29790 ENOG4105ESN nucleotide-binding protein B7R87_RS29810 ENOG4105EVU fructokinase B7R87_RS29825 ENOG4107UWC ABC, transporter B7R87_RS29830 ENOG4105CBG Sulfatase B7R87_RS29850 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) B7R87_RS29865 ENOG4105DXX methyltransferase B7R87_RS29870 ENOG4105DEF Extracellular solute-binding protein, family 5 B7R87_RS29875 ENOG4108JQ7 (ABC) transporter B7R87_RS29880 ENOG4105C3U ABC transporter B7R87_RS29885 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B7R87_RS29900 ENOG4105C26 Dehydrogenase B7R87_RS29910 ENOG4105QPS Monooxygenase B7R87_RS29915 ENOG4105CI0 Citrate lyase B7R87_RS29925 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F B7R87_RS29935 ENOG4108PGP mmge prpd family protein B7R87_RS29940 ENOG4105J4Q Transcriptional regulator B7R87_RS30000 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) B7R87_RS30015 ENOG4105C0W non-ribosomal peptide synthetase B7R87_RS30020 ENOG4105C0A alcohol dehydrogenase B7R87_RS30025 ENOG4105DTI Phosphonopyruvate decarboxylase B7R87_RS30045 ENOG4105CDH Citrulline--aspartate ligase B7R87_RS30080 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) B7R87_RS30085 ENOG4105EUB pirin domain protein B7R87_RS30115 ENOG4105W1Y Transcriptional regulator B7R87_RS30160 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS30200 ENOG4105CIH Imidazole acetol-phosphate transaminase B7R87_RS30225 ENOG4105EZM VWA-like domain (DUF2201) B7R87_RS30235 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) B7R87_RS30245 ENOG4105CR4 methylisocitrate lyase B7R87_RS30255 ENOG4105ECQ AraC Family Transcriptional Regulator B7R87_RS30270 ENOG4105EE1 crotonyl-CoA reductase B7R87_RS30275 ENOG4105VZ8 Transcriptional regulator B7R87_RS30335 ENOG4105CEY Amp-dependent synthetase and ligase B7R87_RS30390 ENOG4105VEQ Cold shock protein B7R87_RS30425 ENOG4106F1P AAA ATPase, central domain protein B7R87_RS30430 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin B7R87_RS30435 ENOG4105EC2 ftsk spoIIIe B7R87_RS30520 ENOG4107VXZ Hydrolase B7R87_RS30570 ENOG4105CTB Polyprenyl synthetase B7R87_RS30580 ENOG4105CFC Transporter B7R87_RS30590 ENOG4107RTD sua5 ycio yrdc ywlc family protein B7R87_RS30595 ENOG4105C26 Dehydrogenase B7R87_RS30620 ENOG4105CHU acetyl-coa acetyltransferase B7R87_RS30630 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase B7R87_RS30635 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit B7R87_RS30640 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit B7R87_RS30645 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit B7R87_RS30650 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit B7R87_RS30655 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) B7R87_RS30660 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) B7R87_RS30675 ENOG4107SCK Monooxygenase B7R87_RS30680 ENOG4105BZU Histidine kinase B7R87_RS30685 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7R87_RS30700 ENOG410626B catechol 1,2-dioxygenase B7R87_RS30725 ENOG4105MHT Transcriptional regulator, ARSR family B7R87_RS30760 ENOG4108Q9V regulatoR B7R87_RS30805 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) B7R87_RS30820 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) B7R87_RS30870 ENOG4108NEV two component transcriptional regulator, LytTR family B7R87_RS30890 ENOG4108HRK Histidine kinase B7R87_RS30945 ENOG4105BZU Histidine kinase B7R87_RS30950 ENOG4105C5Q Transcriptional regulator B7R87_RS30965 ENOG4105E33 succinate dehydrogenase B7R87_RS30975 ENOG4105WKW Pfam:DUF1458 B7R87_RS30985 ENOG41067HS methyltransferase B7R87_RS30990 ENOG4108V75 Glutamine amidotransferase B7R87_RS30995 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process B7R87_RS31000 ENOG4105D1K glutamate--cysteine ligase B7R87_RS31010 ENOG41060NJ transcriptional regulator B7R87_RS31020 ENOG41080RH Thioredoxin B7R87_RS31025 ENOG4107QN2 dihydrolipoyl dehydrogenase B7R87_RS31055 ENOG4105CHJ isochorismatase hydrolase B7R87_RS31070 ENOG4105E1F short-chain dehydrogenase reductase B7R87_RS31075 ENOG4108R85 Short chain dehydrogenase B7R87_RS31080 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) B7R87_RS31105 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) B7R87_RS31180 ENOG4105C8Y Acetylornithine aminotransferase B7R87_RS31200 ENOG4105CIR epoxide hydrolase B7R87_RS31235 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase B7R87_RS31290 ENOG4105BZU Histidine kinase B7R87_RS31295 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS31315 ENOG4105ETS cytosine purines uracil thiamine allantoin B7R87_RS31360 ENOG4105CND Glycosyl transferase, family 2 B7R87_RS31370 ENOG4105C8Y Acetylornithine aminotransferase B7R87_RS31385 ENOG4105CND Glycosyl transferase, family 2 B7R87_RS31400 ENOG4105CPC Aldo Keto reductase B7R87_RS31415 ENOG4105DWV Homoserine O-trans-acetylase B7R87_RS31430 ENOG4108VHC Short-chain dehydrogenase reductase Sdr B7R87_RS31445 ENOG4105DWY Agmatine deiminase B7R87_RS31460 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) B7R87_RS31495 ENOG4108PYU two-component system response regulator B7R87_RS31500 ENOG4108FKE two-component system sensor kinase B7R87_RS31505 ENOG41061WM D-Alanyl-D-Alanine B7R87_RS31515 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin B7R87_RS31525 ENOG4105CGD Nad-dependent epimerase dehydratase B7R87_RS31530 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin B7R87_RS31540 ENOG41065SU Two-component system sensor kinase B7R87_RS31545 ENOG4108KXV response regulator B7R87_RS31570 ENOG4105EUB pirin domain protein B7R87_RS31590 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) B7R87_RS31595 ENOG4105D5P Methylmalonyl-coA mutase B7R87_RS31615 ENOG4105DMF Dehydrogenase B7R87_RS31620 ENOG4108YIQ Alpha beta hydrolase B7R87_RS31640 ENOG4105CHJ isochorismatase hydrolase B7R87_RS31675 ENOG4105KKX ATPase associated with various cellular activities aaa_5 B7R87_RS31705 ENOG4106JDR secreted B7R87_RS31740 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) B7R87_RS31750 ENOG4107R13 MMPL domain protein B7R87_RS31760 ENOG4105D3Q Sugar transferase B7R87_RS31765 ENOG4105C6Y Udp-glucose 6-dehydrogenase B7R87_RS31790 ENOG4107RRD Dehydrogenase B7R87_RS31805 ENOG4108I69 Glycosyl transferases group 1 B7R87_RS31815 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase B7R87_RS31830 ENOG4105EQQ protein containing aminopeptidase domain B7R87_RS31840 ENOG4105K64 Glycosyl transferase, family 2 B7R87_RS31855 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase B7R87_RS31895 ENOG4108TCJ secreted hydrolase B7R87_RS31905 ENOG4105DZC cytosine deaminase B7R87_RS31920 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) B7R87_RS31940 ENOG4105E98 transcriptional regulator DeoR family B7R87_RS31945 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) B7R87_RS31985 ENOG4105DCG PHP domain protein B7R87_RS32030 ENOG4105D0M Protease HtpX homolog B7R87_RS32070 ENOG4105CEY Amp-dependent synthetase and ligase B7R87_RS32070 ENOG4105CEY Amp-dependent synthetase and ligase B7R87_RS32115 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) B7R87_RS32125 ENOG4105E39 Enoyl-CoA hydratase B7R87_RS32130 ENOG4105X7H acyl-CoA dehydrogenase B7R87_RS32140 ENOG4105WH1 Two component transcriptional regulator luxr family B7R87_RS32145 ENOG4105BZU Histidine kinase B7R87_RS32180 ENOG4105CHP RNA polymerase B7R87_RS32185 ENOG4105GRZ Ycii-related protein B7R87_RS32195 ENOG4108JJB ABC transporter B7R87_RS32240 ENOG4105PWE CRISPR-associated protein cas2 B7R87_RS32245 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) B7R87_RS32255 ENOG4108VWQ crispr-associated protein B7R87_RS32260 ENOG41060M0 Crispr-associated protein, cse4 family B7R87_RS32275 ENOG4105DUM transcriptional regulator, lysR family B7R87_RS32285 ENOG4105CHR reductase B7R87_RS32315 ENOG4105CJA serine threonine protein kinase B7R87_RS32350 ENOG4105C5R Aminotransferase B7R87_RS32355 ENOG4105CQB FAD linked oxidase domain protein B7R87_RS32365 ENOG4105E39 Enoyl-CoA hydratase B7R87_RS32390 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein B7R87_RS32435 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) B7R87_RS32465 ENOG4105TVJ transport system, permease B7R87_RS32470 ENOG4105DQ5 transport system permease protein B7R87_RS32500 ENOG4105KHM amidohydrolase 2 B7R87_RS32525 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) B7R87_RS32560 ENOG4105UA4 acetyltransferase B7R87_RS32575 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) B7R87_RS32590 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) B7R87_RS32655 ENOG4107EEY synthase B7R87_RS32685 ENOG4107SQU synthase B7R87_RS32885 ENOG4105C21 Displays ATPase and GTPase activities (By similarity)