locus-tag	class	description
IGS69_RS00205	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IGS69_RS00245	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IGS69_RS00245	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IGS69_RS00400	COG0655	NAD(P)H dehydrogenase (quinone) activity
IGS69_RS00405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IGS69_RS00415	COG0640	Transcriptional regulator
IGS69_RS00420	COG2226	methyltransferase
IGS69_RS00425	COG3835	regulator
IGS69_RS00445	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IGS69_RS00470	COG1271	oxidase subunit
IGS69_RS00500	COG2755	lipolytic protein G-D-S-L family
IGS69_RS00525	COG0667	Aldo Keto reductase
IGS69_RS00530	COG2318	DinB family
IGS69_RS00545	COG2340	Cysteine-rich secretory protein family
IGS69_RS00550	COG2205	protein histidine kinase activity
IGS69_RS00555	COG0745	RESPONSE REGULATOR receiver
IGS69_RS00600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS69_RS00630	COG4948	Mandelate Racemase Muconate Lactonizing
IGS69_RS00645	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IGS69_RS00655	COG0477	Major facilitator Superfamily
IGS69_RS00670	COG1984	allophanate hydrolase subunit 2
IGS69_RS00680	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IGS69_RS00695	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
IGS69_RS00755	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IGS69_RS00780	COG1366	Belongs to the anti-sigma-factor antagonist family
IGS69_RS00795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IGS69_RS00800	COG1518	maintenance of DNA repeat elements
IGS69_RS00855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IGS69_RS00875	COG0515	serine threonine protein kinase
IGS69_RS00875	COG2815	serine threonine protein kinase
IGS69_RS00885	COG2192	nodulation
IGS69_RS00920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IGS69_RS00925	COG1131	(ABC) transporter
IGS69_RS00935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IGS69_RS00940	COG0076	glutamate decarboxylase activity
IGS69_RS00960	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IGS69_RS00980	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IGS69_RS00995	COG2226	methyltransferase
IGS69_RS01000	COG0243	molybdopterin cofactor binding
IGS69_RS01010	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
IGS69_RS01040	COG1191	sigma factor activity
IGS69_RS01050	COG2124	cytochrome p450
IGS69_RS01060	COG1597	lipid kinase activity
IGS69_RS01065	COG0277	FAD linked oxidase domain protein
IGS69_RS01085	COG2909	trisaccharide binding
IGS69_RS01085	COG2909	trisaccharide binding
IGS69_RS01125	COG1597	lipid kinase activity
IGS69_RS01165	COG0662	Cupin 2, conserved barrel domain protein
IGS69_RS01205	COG0205	6-phosphofructokinase activity
IGS69_RS01210	COG2326	polyphosphate kinase activity
IGS69_RS01245	COG1309	transcriptional regulator
IGS69_RS01250	COG0277	FAD linked oxidase domain protein
IGS69_RS01295	COG3739	integral membrane protein
IGS69_RS01315	COG2353	YceI-like domain
IGS69_RS01325	COG0438	transferase activity, transferring glycosyl groups
IGS69_RS01395	COG3290	protein histidine kinase activity
IGS69_RS01435	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IGS69_RS01465	COG0302	gtp cyclohydrolase
IGS69_RS01490	COG1028	Short-chain dehydrogenase reductase Sdr
IGS69_RS01495	COG2326	polyphosphate kinase activity
IGS69_RS01515	COG2080	2 iron, 2 sulfur cluster binding
IGS69_RS01520	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IGS69_RS01525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IGS69_RS01600	COG4948	Mandelate Racemase Muconate Lactonizing
IGS69_RS01605	COG1509	lysine 2,3-aminomutase activity
IGS69_RS01635	COG0667	Aldo Keto reductase
IGS69_RS01640	COG2764	glyoxalase bleomycin resistance protein dioxygenase
IGS69_RS01645	COG3973	AAA domain
IGS69_RS01710	COG0395	ABC-type sugar transport system, permease component
IGS69_RS01725	COG1940	carbohydrate kinase activity
IGS69_RS01795	COG0673	inositol 2-dehydrogenase activity
IGS69_RS01805	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IGS69_RS01830	COG1846	Transcriptional regulator
IGS69_RS01830	COG1940	carbohydrate kinase activity
IGS69_RS01835	COG1175	transmembrane transport
IGS69_RS01895	COG1132	(ABC) transporter
IGS69_RS01925	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IGS69_RS01935	COG2130	NADP-dependent
IGS69_RS01940	COG1063	alcohol dehydrogenase
IGS69_RS02000	COG0517	IMP dehydrogenase activity
IGS69_RS02045	COG2274	protein secretion by the type I secretion system
IGS69_RS02050	COG3832	glyoxalase III activity
IGS69_RS02060	COG0248	Ppx GppA phosphatase
IGS69_RS02075	COG2890	protein-(glutamine-N5) methyltransferase activity
IGS69_RS02130	COG3250	beta-galactosidase activity
IGS69_RS02160	COG0667	Aldo Keto reductase
IGS69_RS02175	COG2124	cytochrome p450
IGS69_RS02195	COG0435	Glutathione S-transferase
IGS69_RS02215	COG2124	cytochrome p450
IGS69_RS02285	COG1028	Short-chain dehydrogenase reductase Sdr
IGS69_RS02290	COG1796	DNA polymerase
IGS69_RS02290	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IGS69_RS02335	COG2706	6-phosphogluconolactonase activity
IGS69_RS02345	COG1309	transcriptional regulator
IGS69_RS02355	COG1357	PFAM Pentapeptide repeats (8 copies)
IGS69_RS02360	COG1595	DNA-templated transcription, initiation
IGS69_RS02375	COG1609	Transcriptional regulator
IGS69_RS02395	COG1172	Belongs to the binding-protein-dependent transport system permease family
IGS69_RS02400	COG1172	Belongs to the binding-protein-dependent transport system permease family
IGS69_RS02405	COG1129	ABC transporter
IGS69_RS02415	COG1028	Short-chain dehydrogenase reductase Sdr
IGS69_RS02415	COG3347	Dehydrogenase
IGS69_RS02420	COG1070	Carbohydrate kinase
IGS69_RS02425	COG0247	lactate metabolic process
IGS69_RS02430	COG1139	Iron-sulfur cluster binding protein
IGS69_RS02435	COG1556	Lactate utilization protein
IGS69_RS02440	COG1028	Short-chain dehydrogenase reductase Sdr
IGS69_RS02455	COG1082	Xylose isomerase domain protein TIM barrel
IGS69_RS02475	COG0542	response to heat
IGS69_RS02515	COG1028	Short-chain dehydrogenase reductase Sdr
IGS69_RS02550	COG0515	serine threonine protein kinase
IGS69_RS02550	COG2815	serine threonine protein kinase
IGS69_RS02555	COG0310	cobalt ion transport
IGS69_RS02560	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
IGS69_RS02570	COG1122	ATPase activity
IGS69_RS02580	COG1132	(ABC) transporter
IGS69_RS02605	COG0477	Major facilitator Superfamily
IGS69_RS02610	COG0477	Major facilitator Superfamily
IGS69_RS02675	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IGS69_RS02695	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IGS69_RS02710	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IGS69_RS02715	COG2188	Transcriptional regulator
IGS69_RS02735	COG1735	metal-dependent hydrolase with the TIM-barrel fold
IGS69_RS02740	COG0626	cystathionine gamma-synthase activity
IGS69_RS02745	COG3457	Alanine racemase
IGS69_RS02750	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IGS69_RS02755	COG1609	Transcriptional regulator
IGS69_RS02760	COG0698	ribose 5-phosphate isomerase
IGS69_RS02800	COG0242	peptide deformylase activity
IGS69_RS02810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IGS69_RS02820	COG1609	Transcriptional regulator
IGS69_RS02840	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IGS69_RS02845	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IGS69_RS02850	COG2080	2 iron, 2 sulfur cluster binding
IGS69_RS02860	COG0583	DNA-binding transcription factor activity
IGS69_RS02870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IGS69_RS02890	COG4977	sequence-specific DNA binding
IGS69_RS02910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IGS69_RS02915	COG1881	PFAM PEBP family protein
IGS69_RS02945	COG0515	serine threonine protein kinase
IGS69_RS02945	COG2815	serine threonine protein kinase
IGS69_RS02990	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IGS69_RS02995	COG0121	glutamine amidotransferase
IGS69_RS03000	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IGS69_RS03005	COG3360	Dodecin
IGS69_RS03020	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IGS69_RS03050	COG2197	response regulator
IGS69_RS03055	COG4585	Histidine kinase
IGS69_RS03080	COG1660	Displays ATPase and GTPase activities
IGS69_RS03095	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IGS69_RS03125	COG0515	serine threonine protein kinase
IGS69_RS03140	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IGS69_RS03165	COG0204	Acyl-transferase
IGS69_RS03195	COG0584	glycerophosphoryl diester phosphodiesterase
IGS69_RS03215	COG1846	Transcriptional regulator
IGS69_RS03235	COG0671	phosphoesterase, PA-phosphatase related
IGS69_RS03240	COG1309	transcriptional regulator
IGS69_RS03255	COG1309	transcriptional regulator
IGS69_RS03270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGS69_RS03270	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IGS69_RS03295	COG0640	Transcriptional regulator
IGS69_RS03300	COG1902	pentaerythritol trinitrate reductase activity
IGS69_RS03315	COG1960	acyl-CoA dehydrogenase activity
IGS69_RS03335	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IGS69_RS03365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IGS69_RS03510	COG1012	belongs to the aldehyde dehydrogenase family
IGS69_RS03550	COG1522	sequence-specific DNA binding
IGS69_RS03585	COG2124	cytochrome p450
IGS69_RS03615	COG0432	Pfam Uncharacterised protein family UPF0047
IGS69_RS03620	COG2072	flavoprotein involved in K transport
IGS69_RS03630	COG1132	(ABC) transporter
IGS69_RS03645	COG1132	(ABC) transporter
IGS69_RS03650	COG1132	(ABC) transporter
IGS69_RS03660	COG0254	rRNA binding
IGS69_RS03675	COG1946	Acyl-CoA thioesterase
IGS69_RS03690	COG2018	Roadblock/LC7 domain
IGS69_RS03750	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IGS69_RS03775	COG1846	Transcriptional regulator
IGS69_RS03775	COG1940	carbohydrate kinase activity
IGS69_RS03790	COG1051	belongs to the nudix hydrolase family
IGS69_RS03810	COG1960	acyl-CoA dehydrogenase activity
IGS69_RS03815	COG1960	acyl-CoA dehydrogenase activity
IGS69_RS03825	COG3800	Transcriptional regulator
IGS69_RS03825	COG1396	sequence-specific DNA binding
IGS69_RS03830	COG3634	alkyl hydroperoxide reductase activity
IGS69_RS03835	COG1793	dna ligase
IGS69_RS03845	COG1012	belongs to the aldehyde dehydrogenase family
IGS69_RS03860	COG3424	synthase
IGS69_RS03875	COG1960	acyl-CoA dehydrogenase activity
IGS69_RS03885	COG0242	peptide deformylase activity
IGS69_RS03895	COG3442	glutamine amidotransferase
IGS69_RS03900	COG0205	6-phosphofructokinase activity
IGS69_RS03915	COG3275	phosphorelay sensor kinase activity
IGS69_RS03920	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IGS69_RS03930	COG3279	Response regulator of the LytR AlgR family
IGS69_RS03935	COG1522	sequence-specific DNA binding
IGS69_RS03940	COG1834	amidinotransferase
IGS69_RS03945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IGS69_RS03975	COG0829	nickel cation binding
IGS69_RS03980	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IGS69_RS03990	COG0804	urea catabolic process
IGS69_RS03995	COG0832	Belongs to the urease beta subunit family
IGS69_RS04000	COG0831	urea catabolic process
IGS69_RS04005	COG1309	transcriptional regulator
IGS69_RS04055	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IGS69_RS04060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IGS69_RS04065	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IGS69_RS04080	COG2226	methyltransferase
IGS69_RS04095	COG0577	efflux transmembrane transporter activity
IGS69_RS04095	COG1136	(ABC) transporter
IGS69_RS04100	COG2177	Part of the ABC transporter FtsEX involved in
IGS69_RS04105	COG0456	acetyltransferase
IGS69_RS04125	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IGS69_RS04130	COG3663	DNA glycosylase
IGS69_RS04150	COG4585	Histidine kinase
IGS69_RS04155	COG2197	response regulator
IGS69_RS04160	COG1940	carbohydrate kinase activity
IGS69_RS04165	COG2188	Transcriptional regulator
IGS69_RS04170	COG1595	DNA-templated transcription, initiation
IGS69_RS04185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGS69_RS04200	COG0626	cystathionine gamma-synthase activity
IGS69_RS04225	COG1522	sequence-specific DNA binding
IGS69_RS04230	COG0419	ATPase involved in DNA repair
IGS69_RS04235	COG0420	3'-5' exonuclease activity
IGS69_RS04240	COG1739	Uncharacterized protein family UPF0029
IGS69_RS04260	COG1832	CoA-binding protein
IGS69_RS04270	COG0640	Transcriptional regulator
IGS69_RS04295	COG0110	maltose O-acetyltransferase activity
IGS69_RS04310	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IGS69_RS04340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IGS69_RS04350	COG0183	Belongs to the thiolase family
IGS69_RS04360	COG1968	undecaprenyl-diphosphatase activity
IGS69_RS04380	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IGS69_RS04390	COG2318	DinB family
IGS69_RS04405	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IGS69_RS04460	COG0697	spore germination
IGS69_RS04500	COG0384	phenazine biosynthesis protein PhzF
IGS69_RS04535	COG0395	ABC-type sugar transport system, permease component
IGS69_RS04540	COG1175	transmembrane transport
IGS69_RS04570	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IGS69_RS04570	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IGS69_RS04580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IGS69_RS04620	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IGS69_RS04650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IGS69_RS04660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IGS69_RS04675	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IGS69_RS04685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IGS69_RS04695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IGS69_RS04700	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IGS69_RS04720	COG2018	Roadblock/LC7 domain
IGS69_RS04735	COG0531	amino acid
IGS69_RS04760	COG2814	Major facilitator Superfamily
IGS69_RS04765	COG4336	lyase activity
IGS69_RS04775	COG2755	lipolytic protein G-D-S-L family
IGS69_RS04780	COG0438	transferase activity, transferring glycosyl groups
IGS69_RS04810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGS69_RS04825	COG2270	Major facilitator Superfamily
IGS69_RS04840	COG1216	Glycosyl transferase, family 2
IGS69_RS04860	COG1960	acyl-CoA dehydrogenase activity
IGS69_RS04910	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IGS69_RS04915	COG0140	phosphoribosyl-ATP diphosphatase activity
IGS69_RS04920	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IGS69_RS04925	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IGS69_RS04925	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IGS69_RS04930	COG3201	nicotinamide mononucleotide transporter
IGS69_RS04940	COG1940	carbohydrate kinase activity
IGS69_RS04940	COG1846	Transcriptional regulator
IGS69_RS04945	COG2223	nitrite transmembrane transporter activity
IGS69_RS04950	COG2233	PERMEase
IGS69_RS04970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IGS69_RS04990	COG0531	amino acid
IGS69_RS05005	COG2390	Transcriptional regulator
IGS69_RS05010	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IGS69_RS05015	COG2409	Drug exporters of the RND superfamily
IGS69_RS05025	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IGS69_RS05040	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IGS69_RS05050	COG1758	RNA polymerase activity
IGS69_RS05055	COG0194	GDP metabolic process
IGS69_RS05065	COG0284	orotidine-5'-phosphate decarboxylase activity
IGS69_RS05070	COG0167	dihydroorotate dehydrogenase activity
IGS69_RS05075	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IGS69_RS05080	COG0505	Belongs to the CarA family
IGS69_RS05090	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IGS69_RS05095	COG0540	Belongs to the ATCase OTCase family
IGS69_RS05100	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IGS69_RS05110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IGS69_RS05115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IGS69_RS05120	COG0006	proline dipeptidase activity
IGS69_RS05130	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IGS69_RS05135	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IGS69_RS05140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IGS69_RS05150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IGS69_RS05160	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IGS69_RS05165	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IGS69_RS05180	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IGS69_RS05195	COG0124	histidyl-tRNA synthetase
IGS69_RS05205	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IGS69_RS05210	COG1196	nuclear chromosome segregation
IGS69_RS05215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IGS69_RS05220	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IGS69_RS05225	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IGS69_RS05230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IGS69_RS05240	COG2255	four-way junction helicase activity
IGS69_RS05245	COG0632	four-way junction helicase activity
IGS69_RS05250	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IGS69_RS05255	COG0217	transcriptional regulatory protein
IGS69_RS05260	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IGS69_RS05265	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IGS69_RS05275	COG0438	transferase activity, transferring glycosyl groups
IGS69_RS05280	COG1560	Kdo2-lipid A biosynthetic process
IGS69_RS05285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IGS69_RS05305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IGS69_RS05320	COG2176	DNA-directed DNA polymerase activity
IGS69_RS05320	COG5002	protein histidine kinase activity
IGS69_RS05345	COG0019	diaminopimelate decarboxylase activity
IGS69_RS05365	COG0395	ABC-type sugar transport system, permease component
IGS69_RS05370	COG1175	transmembrane transport
IGS69_RS05425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IGS69_RS05480	COG2816	NAD+ diphosphatase activity
IGS69_RS05490	COG1648	precorrin-2 dehydrogenase activity
IGS69_RS05490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IGS69_RS05495	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IGS69_RS05510	COG1464	Belongs to the NlpA lipoprotein family
IGS69_RS05515	COG2011	ABC-type metal ion transport system permease component
IGS69_RS05520	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IGS69_RS05550	COG0584	glycerophosphoryl diester phosphodiesterase
IGS69_RS05555	COG0318	PFAM AMP-dependent synthetase and ligase
IGS69_RS05555	COG0204	Acyl-transferase
IGS69_RS05560	COG0477	Major facilitator Superfamily
IGS69_RS05575	COG0165	Argininosuccinate lyase
IGS69_RS05590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IGS69_RS05590	COG1017	nitric oxide dioxygenase activity
IGS69_RS05605	COG1438	arginine binding
IGS69_RS05610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IGS69_RS05615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IGS69_RS05620	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IGS69_RS05625	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IGS69_RS05660	COG0697	spore germination
IGS69_RS05670	COG1649	PFAM Uncharacterised BCR, COG1649
IGS69_RS05700	COG0072	phenylalanine-tRNA ligase activity
IGS69_RS05700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IGS69_RS05705	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IGS69_RS05710	COG5002	protein histidine kinase activity
IGS69_RS05715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IGS69_RS05720	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IGS69_RS05725	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IGS69_RS05730	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IGS69_RS05765	COG1028	Short-chain dehydrogenase reductase Sdr
IGS69_RS05770	COG1012	belongs to the aldehyde dehydrogenase family
IGS69_RS05775	COG0174	glutamine synthetase
IGS69_RS05785	COG0531	amino acid
IGS69_RS05790	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IGS69_RS05815	COG4176	ABC-type proline glycine betaine transport system permease component
IGS69_RS05820	COG0517	IMP dehydrogenase activity
IGS69_RS05820	COG4175	Glycine betaine
IGS69_RS05825	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IGS69_RS05875	COG0805	protein transport
IGS69_RS05880	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IGS69_RS05900	COG2378	regulation of single-species biofilm formation
IGS69_RS05915	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IGS69_RS05925	COG1609	Transcriptional regulator
IGS69_RS05930	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IGS69_RS05935	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IGS69_RS05950	COG4122	O-methyltransferase activity
IGS69_RS05955	COG1222	aaa ATPase
IGS69_RS05975	COG1994	Peptidase M50
IGS69_RS05975	COG0517	IMP dehydrogenase activity
IGS69_RS05985	COG2197	response regulator
IGS69_RS05990	COG0747	negative chemotaxis
IGS69_RS06005	COG0646	methionine synthase
IGS69_RS06005	COG1410	methionine synthase
IGS69_RS06010	COG1414	Transcriptional regulator
IGS69_RS06015	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IGS69_RS06020	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IGS69_RS06025	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IGS69_RS06030	COG2186	Transcriptional regulator
IGS69_RS06040	COG0215	cysteine-tRNA ligase activity
IGS69_RS06055	COG0588	phosphoglycerate mutase activity
IGS69_RS06060	COG0598	Magnesium transport protein CorA
IGS69_RS06070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS69_RS06075	COG0667	Aldo Keto reductase
IGS69_RS06105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGS69_RS06115	COG3012	SEC-C Motif Domain Protein
IGS69_RS06120	COG2186	Transcriptional regulator
IGS69_RS06125	COG3265	gluconokinase activity
IGS69_RS06165	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IGS69_RS06170	COG2149	membrane
IGS69_RS06190	COG1960	acyl-CoA dehydrogenase activity
IGS69_RS06215	COG0318	PFAM AMP-dependent synthetase and ligase
IGS69_RS06225	COG3876	Protein conserved in bacteria
IGS69_RS06250	COG0789	Transcriptional regulator
IGS69_RS06270	COG1960	acyl-CoA dehydrogenase activity
IGS69_RS06280	COG0640	Transcriptional regulator
IGS69_RS06290	COG0477	Major facilitator Superfamily
IGS69_RS06325	COG2851	Citrate transporter
IGS69_RS06330	COG0243	molybdopterin cofactor binding
IGS69_RS06335	COG1309	transcriptional regulator
IGS69_RS06345	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IGS69_RS06350	COG2188	Transcriptional regulator
IGS69_RS06385	COG1595	DNA-templated transcription, initiation
IGS69_RS06410	COG2755	lipolytic protein G-D-S-L family
IGS69_RS06425	COG1216	Glycosyl transferase, family 2
IGS69_RS06430	COG0726	polysaccharide deacetylase
IGS69_RS06430	COG1649	PFAM Uncharacterised BCR, COG1649
IGS69_RS06445	COG1725	Transcriptional regulator
IGS69_RS06460	COG2226	methyltransferase
IGS69_RS06485	COG0587	DNA-directed DNA polymerase activity
IGS69_RS06510	COG1799	cell septum assembly
IGS69_RS06515	COG1960	acyl-CoA dehydrogenase activity
IGS69_RS06520	COG0477	Major facilitator Superfamily
IGS69_RS06530	COG0671	phosphoesterase, PA-phosphatase related
IGS69_RS06540	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IGS69_RS06565	COG0411	ABC transporter
IGS69_RS06575	COG1652	LysM domain
IGS69_RS06590	COG1160	GTP binding
IGS69_RS06600	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IGS69_RS06625	COG0494	nUDIX hydrolase
IGS69_RS06630	COG1187	pseudouridine synthase activity
IGS69_RS06635	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IGS69_RS06640	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IGS69_RS06655	COG0686	Belongs to the AlaDH PNT family
IGS69_RS06665	COG0494	nUDIX hydrolase
IGS69_RS06670	COG0504	CTP synthase activity
IGS69_RS06675	COG3387	PFAM Glycoside hydrolase 15-related
IGS69_RS06695	COG0497	DNA recombination
IGS69_RS06700	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IGS69_RS06720	COG1120	ATPase activity
IGS69_RS06725	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IGS69_RS06730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IGS69_RS06735	COG0647	UMP catabolic process
IGS69_RS06765	COG2094	Belongs to the DNA glycosylase MPG family
IGS69_RS06775	COG1881	PFAM PEBP family protein
IGS69_RS06795	COG1119	ATPase activity
IGS69_RS06810	COG2197	response regulator
IGS69_RS06835	COG0842	Transport permease protein
IGS69_RS06835	COG1716	ATPase activity
IGS69_RS06835	COG1131	(ABC) transporter
IGS69_RS06845	COG3830	Belongs to the UPF0237 family
IGS69_RS06845	COG0560	Phosphoserine phosphatase
IGS69_RS06850	COG0588	phosphoglycerate mutase activity
IGS69_RS06860	COG2807	transmembrane transport
IGS69_RS06865	COG2186	Transcriptional regulator
IGS69_RS06895	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IGS69_RS06900	COG2261	transglycosylase associated protein
IGS69_RS06915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IGS69_RS06920	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IGS69_RS06960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IGS69_RS06975	COG3387	PFAM Glycoside hydrolase 15-related
IGS69_RS07025	COG0488	(ABC) transporter
IGS69_RS07045	COG0235	Class ii aldolase
IGS69_RS07065	COG1492	cobalamin metabolic process
IGS69_RS07085	COG1797	cobyrinic acid a,c-diamide synthase activity
IGS69_RS07115	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
IGS69_RS07135	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IGS69_RS07140	COG2318	DinB family
IGS69_RS07145	COG0456	acetyltransferase
IGS69_RS07150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IGS69_RS07155	COG1917	Cupin 2, conserved barrel domain protein
IGS69_RS07160	COG5285	phytanoyl-CoA dioxygenase
IGS69_RS07170	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IGS69_RS07190	COG1414	Transcriptional regulator
IGS69_RS07205	COG4585	Histidine kinase
IGS69_RS07210	COG2197	response regulator
IGS69_RS07215	COG0768	penicillin binding
IGS69_RS07220	COG2252	PERMEase
IGS69_RS07230	COG4677	pectinesterase activity
IGS69_RS07250	COG0395	ABC-type sugar transport system, permease component
IGS69_RS07255	COG1175	transmembrane transport
IGS69_RS07270	COG1802	Transcriptional regulator
IGS69_RS07295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IGS69_RS07300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IGS69_RS07320	COG0395	ABC-type sugar transport system, permease component
IGS69_RS07325	COG1063	alcohol dehydrogenase
IGS69_RS07340	COG1309	transcriptional regulator
IGS69_RS07345	COG1609	Transcriptional regulator
IGS69_RS07360	COG1802	Transcriptional regulator
IGS69_RS07405	COG1595	DNA-templated transcription, initiation
IGS69_RS07415	COG2171	N-acyltransferase activity
IGS69_RS07420	COG3226	Transcriptional regulator
IGS69_RS07425	COG2076	Multidrug Resistance protein
IGS69_RS07435	COG2151	metal-sulfur cluster biosynthetic enzyme
IGS69_RS07440	COG0822	iron-sulfur transferase activity
IGS69_RS07445	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IGS69_RS07450	COG0396	ATPase activity
IGS69_RS07460	COG0719	Fe-S assembly protein
IGS69_RS07475	COG2746	aminoglycoside 3-N-acetyltransferase activity
IGS69_RS07480	COG1131	(ABC) transporter
IGS69_RS07490	COG1612	heme a metabolic process
IGS69_RS07505	COG0109	protoheme IX farnesyltransferase activity
IGS69_RS07515	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IGS69_RS07530	COG0363	glucosamine-6-phosphate deaminase activity
IGS69_RS07535	COG0395	ABC-type sugar transport system, permease component
IGS69_RS07540	COG1175	transmembrane transport
IGS69_RS07550	COG0366	Alpha amylase catalytic
IGS69_RS07560	COG1695	Transcriptional regulator
IGS69_RS07565	COG1136	(ABC) transporter
IGS69_RS07580	COG0166	Belongs to the GPI family
IGS69_RS07595	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IGS69_RS07600	COG0149	triose-phosphate isomerase activity
IGS69_RS07605	COG0126	phosphoglycerate kinase activity
IGS69_RS07610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IGS69_RS07620	COG1481	regulation of sporulation
IGS69_RS07625	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IGS69_RS07630	COG1660	Displays ATPase and GTPase activities
IGS69_RS07635	COG0322	excinuclease ABC activity
IGS69_RS07670	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IGS69_RS07685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS69_RS07690	COG0765	amino acid transport
IGS69_RS07700	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IGS69_RS07705	COG1619	proteins homologs of microcin C7 resistance protein MccF
IGS69_RS07710	COG0477	Major facilitator Superfamily
IGS69_RS07715	COG0387	Pfam Sodium calcium exchanger
IGS69_RS07740	COG0556	nucleotide-excision repair
IGS69_RS07750	COG0584	glycerophosphoryl diester phosphodiesterase
IGS69_RS07755	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IGS69_RS07765	COG2313	pseudouridylate synthase activity
IGS69_RS07770	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IGS69_RS07770	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IGS69_RS07775	COG2226	methyltransferase
IGS69_RS07780	COG0598	Magnesium transport protein CorA
IGS69_RS07810	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IGS69_RS07815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGS69_RS07845	COG1132	(ABC) transporter
IGS69_RS07890	COG1953	Uracil, thiamine, allantoin
IGS69_RS07895	COG1802	Transcriptional regulator
IGS69_RS07925	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IGS69_RS07940	COG0237	dephospho-CoA kinase activity
IGS69_RS07950	COG0539	negative regulation of cytoplasmic translation
IGS69_RS07960	COG1643	Atp-dependent helicase
IGS69_RS08000	COG2050	protein possibly involved in aromatic compounds catabolism
IGS69_RS08055	COG0737	Belongs to the 5'-nucleotidase family
IGS69_RS08075	COG0745	RESPONSE REGULATOR receiver
IGS69_RS08080	COG1605	Chorismate mutase
IGS69_RS08080	COG0287	Prephenate dehydrogenase
IGS69_RS08095	COG1028	Short-chain dehydrogenase reductase Sdr
IGS69_RS08105	COG1024	Enoyl-CoA hydratase
IGS69_RS08125	COG0183	Belongs to the thiolase family
IGS69_RS08135	COG1028	Short-chain dehydrogenase reductase Sdr
IGS69_RS08140	COG1960	acyl-CoA dehydrogenase activity
IGS69_RS08150	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IGS69_RS08155	COG2304	oxidoreductase activity
IGS69_RS08160	COG1136	(ABC) transporter
IGS69_RS08160	COG4591	ABC-type transport system involved in lipoprotein release permease component
IGS69_RS08185	COG0069	glutamate synthase activity
IGS69_RS08185	COG0070	glutamate synthase
IGS69_RS08185	COG0067	glutamate synthase
IGS69_RS08195	COG1397	ADP-ribosylglycohydrolase
IGS69_RS08215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IGS69_RS08225	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IGS69_RS08235	COG0159	tryptophan synthase activity
IGS69_RS08240	COG0133	tryptophan synthase activity
IGS69_RS08250	COG0134	indole-3-glycerol-phosphate synthase activity
IGS69_RS08270	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IGS69_RS08275	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IGS69_RS08285	COG0107	imidazoleglycerol-phosphate synthase activity
IGS69_RS08290	COG0251	oxidation-reduction process
IGS69_RS08295	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IGS69_RS08300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IGS69_RS08310	COG0131	Imidazoleglycerol-phosphate dehydratase
IGS69_RS08315	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IGS69_RS08320	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IGS69_RS08340	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IGS69_RS08360	COG1432	Conserved Protein
IGS69_RS08370	COG0587	DNA-directed DNA polymerase activity
IGS69_RS08425	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IGS69_RS08435	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IGS69_RS08440	COG3599	regulation of cell shape
IGS69_RS08450	COG1799	cell septum assembly
IGS69_RS08460	COG1496	oxidoreductase activity
IGS69_RS08465	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IGS69_RS08470	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IGS69_RS08475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IGS69_RS08485	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IGS69_RS08490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IGS69_RS08500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IGS69_RS08515	COG0275	rRNA processing
IGS69_RS08525	COG0714	Associated with various cellular activities
IGS69_RS08545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IGS69_RS08555	COG1129	ABC transporter
IGS69_RS08565	COG1309	transcriptional regulator
IGS69_RS08585	COG0352	thiamine-phosphate diphosphorylase activity
IGS69_RS08605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGS69_RS08605	COG2022	thiamine diphosphate biosynthetic process
IGS69_RS08615	COG2022	thiamine diphosphate biosynthetic process
IGS69_RS08620	COG2815	serine threonine protein kinase
IGS69_RS08620	COG0515	serine threonine protein kinase
IGS69_RS08625	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IGS69_RS08630	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IGS69_RS08635	COG2193	ferroxidase activity
IGS69_RS08640	COG0243	molybdopterin cofactor binding
IGS69_RS08645	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IGS69_RS08660	COG0205	6-phosphofructokinase activity
IGS69_RS08665	COG2197	response regulator
IGS69_RS08670	COG4585	Histidine kinase
IGS69_RS08695	COG1940	carbohydrate kinase activity
IGS69_RS08705	COG0003	Pfam Anion-transporting ATPase
IGS69_RS08720	COG1022	Amp-dependent synthetase and ligase
IGS69_RS08740	COG0534	Mate efflux family protein
IGS69_RS08790	COG2205	protein histidine kinase activity
IGS69_RS08795	COG0745	RESPONSE REGULATOR receiver
IGS69_RS08805	COG1929	Belongs to the glycerate kinase type-1 family
IGS69_RS08810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IGS69_RS08815	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IGS69_RS08820	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IGS69_RS08825	COG0723	plastoquinol--plastocyanin reductase activity
IGS69_RS08830	COG2010	Cytochrome c
IGS69_RS08835	COG1845	cytochrome c oxidase, subunit III
IGS69_RS08845	COG1376	ErfK ybiS ycfS ynhG family protein
IGS69_RS08855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IGS69_RS08860	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IGS69_RS08865	COG1104	cysteine desulfurase activity
IGS69_RS08870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IGS69_RS08890	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IGS69_RS08895	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IGS69_RS08895	COG0515	serine threonine protein kinase
IGS69_RS08900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IGS69_RS08905	COG2197	response regulator
IGS69_RS08910	COG4585	Histidine kinase
IGS69_RS08930	COG2226	methyltransferase
IGS69_RS08950	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IGS69_RS08965	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IGS69_RS08980	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IGS69_RS08985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IGS69_RS08990	COG0508	dehydrogenase complex catalyzes the overall conversion of
IGS69_RS09000	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IGS69_RS09035	COG1090	epimerase
IGS69_RS09050	COG0321	lipoyl(octanoyl) transferase activity
IGS69_RS09055	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IGS69_RS09075	COG0174	glutamine synthetase
IGS69_RS09095	COG0501	Belongs to the peptidase M48B family
IGS69_RS09130	COG0745	RESPONSE REGULATOR receiver
IGS69_RS09160	COG1309	transcriptional regulator
IGS69_RS09180	COG0366	Alpha amylase catalytic
IGS69_RS09185	COG3833	ABC-type maltose transport systems, permease component
IGS69_RS09190	COG1175	transmembrane transport
IGS69_RS09200	COG1609	Transcriptional regulator
IGS69_RS09210	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IGS69_RS09240	COG0174	glutamine synthetase
IGS69_RS09250	COG1959	2 iron, 2 sulfur cluster binding
IGS69_RS09265	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IGS69_RS09265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IGS69_RS09270	COG0346	lactoylglutathione lyase activity
IGS69_RS09275	COG2814	Major facilitator Superfamily
IGS69_RS09290	COG0477	Major facilitator Superfamily
IGS69_RS09295	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IGS69_RS09315	COG1994	Peptidase M50
IGS69_RS09345	COG5398	heme oxygenase
IGS69_RS09365	COG2837	iron assimilation
IGS69_RS09370	COG0672	)-iron permease
IGS69_RS09385	COG0584	glycerophosphoryl diester phosphodiesterase
IGS69_RS09430	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IGS69_RS09435	COG2814	Major facilitator Superfamily
IGS69_RS09445	COG1028	Short-chain dehydrogenase reductase Sdr
IGS69_RS09455	COG2259	Doxx family
IGS69_RS09495	COG3022	response to hydroperoxide
IGS69_RS09500	COG0800	Aldolase
IGS69_RS09515	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IGS69_RS09530	COG1028	Short-chain dehydrogenase reductase Sdr
IGS69_RS09540	COG2030	dehydratase
IGS69_RS09560	COG0477	Major facilitator Superfamily
IGS69_RS09575	COG0860	N-Acetylmuramoyl-L-alanine amidase
IGS69_RS09575	COG2247	cell wall binding repeat
IGS69_RS09585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS69_RS09605	COG0438	transferase activity, transferring glycosyl groups
IGS69_RS09610	COG1309	transcriptional regulator
IGS69_RS09655	COG3845	ABC transporter
IGS69_RS09665	COG2124	cytochrome p450
IGS69_RS09670	COG0183	Belongs to the thiolase family
IGS69_RS09705	COG4122	O-methyltransferase activity
IGS69_RS09770	COG2259	Doxx family
IGS69_RS09790	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IGS69_RS09825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IGS69_RS09835	COG0586	Pfam SNARE associated Golgi protein
IGS69_RS09845	COG1358	cellular component organization or biogenesis
IGS69_RS09890	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IGS69_RS09895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IGS69_RS09905	COG0477	Major facilitator Superfamily
IGS69_RS09910	COG1309	transcriptional regulator
IGS69_RS09925	COG0667	Aldo Keto reductase
IGS69_RS09930	COG0789	Transcriptional regulator
IGS69_RS09940	COG1741	Belongs to the pirin family
IGS69_RS09955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IGS69_RS09960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IGS69_RS09965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IGS69_RS10010	COG1764	response to oxidative stress
IGS69_RS10015	COG2130	NADP-dependent
IGS69_RS10050	COG1129	ABC transporter
IGS69_RS10055	COG4214	carbohydrate transport
IGS69_RS10065	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IGS69_RS10115	COG3386	PFAM SMP-30 Gluconolaconase
IGS69_RS10120	COG1414	Transcriptional regulator
IGS69_RS10155	COG4981	capsule polysaccharide biosynthetic process
IGS69_RS10190	COG0477	Major facilitator Superfamily
IGS69_RS10200	COG2186	Transcriptional regulator
IGS69_RS10210	COG0318	PFAM AMP-dependent synthetase and ligase
IGS69_RS10215	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IGS69_RS10215	COG0825	malonyl-CoA metabolic process
IGS69_RS10230	COG2255	four-way junction helicase activity
IGS69_RS10240	COG1077	Cell shape determining protein MreB Mrl
IGS69_RS10300	COG1070	Carbohydrate kinase
IGS69_RS10315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IGS69_RS10320	COG0358	DNA primase activity
IGS69_RS10330	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IGS69_RS10340	COG2949	membrane
IGS69_RS10345	COG0243	molybdopterin cofactor binding
IGS69_RS10360	COG0431	NADPH-dependent FMN reductase
IGS69_RS10385	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IGS69_RS10385	COG2146	nitrite reductase [NAD(P)H] activity
IGS69_RS10410	COG0659	secondary active sulfate transmembrane transporter activity
IGS69_RS10420	COG0745	RESPONSE REGULATOR receiver
IGS69_RS10425	COG0642	Histidine kinase
IGS69_RS10570	COG4974	Belongs to the 'phage' integrase family
IGS69_RS10575	COG0574	Belongs to the PEP-utilizing enzyme family
IGS69_RS10575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IGS69_RS10580	COG1846	Transcriptional regulator
IGS69_RS10580	COG1940	carbohydrate kinase activity
IGS69_RS10585	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
IGS69_RS10625	COG0423	glycine-tRNA ligase activity
IGS69_RS10630	COG0803	Belongs to the bacterial solute-binding protein 9 family
IGS69_RS10630	COG3443	Belongs to the bacterial solute-binding protein 9 family
IGS69_RS10635	COG1121	(ABC) transporter
IGS69_RS10640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IGS69_RS10655	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IGS69_RS10660	COG1381	Involved in DNA repair and RecF pathway recombination
IGS69_RS10675	COG2186	Transcriptional regulator
IGS69_RS10680	COG0747	negative chemotaxis
IGS69_RS10695	COG4608	Belongs to the ABC transporter superfamily
IGS69_RS10700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IGS69_RS10710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IGS69_RS10725	COG2723	6-phospho-beta-galactosidase activity
IGS69_RS10735	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IGS69_RS10750	COG2315	Protein conserved in bacteria
IGS69_RS10760	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IGS69_RS10775	COG4948	Mandelate Racemase Muconate Lactonizing
IGS69_RS10790	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IGS69_RS10795	COG1234	tRNA 3'-trailer cleavage
IGS69_RS10800	COG0537	adenosine 5'-monophosphoramidase activity
IGS69_RS10805	COG0793	Belongs to the peptidase S41A family
IGS69_RS10805	COG4946	Tricorn protease homolog
IGS69_RS10820	COG2070	2-Nitropropane dioxygenase
IGS69_RS10825	COG0484	heat shock protein binding
IGS69_RS10830	COG1420	regulation of RNA biosynthetic process
IGS69_RS10855	COG2205	protein histidine kinase activity
IGS69_RS10855	COG0784	Response regulator, receiver
IGS69_RS10870	COG0481	GTPase activity
IGS69_RS10875	COG0268	Binds directly to 16S ribosomal RNA
IGS69_RS10905	COG1234	tRNA 3'-trailer cleavage
IGS69_RS10910	COG1555	photosystem II stabilization
IGS69_RS10915	COG1307	EDD domain protein, DegV family
IGS69_RS10925	COG0495	leucyl-tRNA aminoacylation
IGS69_RS10935	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IGS69_RS10960	COG0588	phosphoglycerate mutase activity
IGS69_RS10965	COG0799	negative regulation of ribosome biogenesis
IGS69_RS10975	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IGS69_RS10990	COG0501	Belongs to the peptidase M48B family
IGS69_RS11005	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IGS69_RS11015	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IGS69_RS11025	COG1215	transferase activity, transferring glycosyl groups
IGS69_RS11040	COG3540	Alkaline phosphatase
IGS69_RS11050	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IGS69_RS11055	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IGS69_RS11060	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IGS69_RS11065	COG1530	ribonuclease E activity
IGS69_RS11080	COG3655	Transcriptional regulator
IGS69_RS11110	COG0772	Belongs to the SEDS family
IGS69_RS11130	COG1077	Cell shape determining protein MreB Mrl
IGS69_RS11135	COG0105	UTP biosynthetic process
IGS69_RS11145	COG0285	dihydrofolate synthase activity
IGS69_RS11150	COG0525	valine-tRNA ligase activity
IGS69_RS11160	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IGS69_RS11165	COG0740	serine-type endopeptidase activity
IGS69_RS11170	COG0740	serine-type endopeptidase activity
IGS69_RS11175	COG0544	peptidyl-prolyl cis-trans isomerase activity
IGS69_RS11195	COG0515	serine threonine protein kinase
IGS69_RS11195	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IGS69_RS11205	COG3594	Acyltransferase
IGS69_RS11220	COG4552	Acetyltransferase involved in intracellular survival and related
IGS69_RS11235	COG1113	amino acid transport
IGS69_RS11240	COG0515	serine threonine protein kinase
IGS69_RS11255	COG1940	carbohydrate kinase activity
IGS69_RS11265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IGS69_RS11270	COG1116	anion transmembrane transporter activity
IGS69_RS11285	COG1113	amino acid transport
IGS69_RS11295	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IGS69_RS11300	COG3547	Transposase (IS116 IS110 IS902 family)
IGS69_RS11305	COG0406	alpha-ribazole phosphatase activity
IGS69_RS11310	COG1070	Carbohydrate kinase
IGS69_RS11315	COG1653	transport
IGS69_RS11320	COG1175	transmembrane transport
IGS69_RS11325	COG0395	ABC-type sugar transport system, permease component
IGS69_RS11330	COG3842	ATPase activity
IGS69_RS11335	COG1349	DNA-binding transcription factor activity
IGS69_RS11340	COG3842	ATPase activity
IGS69_RS11355	COG0584	glycerophosphoryl diester phosphodiesterase
IGS69_RS11365	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IGS69_RS11405	COG1136	(ABC) transporter
IGS69_RS11455	COG0697	spore germination
IGS69_RS11460	COG1846	Transcriptional regulator
IGS69_RS11480	COG3291	Pkd domain containing protein
IGS69_RS11480	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IGS69_RS11490	COG1136	(ABC) transporter
IGS69_RS11505	COG0668	transmembrane transport
IGS69_RS11510	COG1940	carbohydrate kinase activity
IGS69_RS11520	COG1175	transmembrane transport
IGS69_RS11525	COG0395	ABC-type sugar transport system, permease component
IGS69_RS11530	COG1486	melibiose metabolic process
IGS69_RS11545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS69_RS11575	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IGS69_RS11580	COG2346	COG2346, Truncated hemoglobins
IGS69_RS11620	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IGS69_RS11715	COG0629	single-stranded DNA binding
IGS69_RS11740	COG3547	Transposase (IS116 IS110 IS902 family)
IGS69_RS11780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IGS69_RS11790	COG2304	oxidoreductase activity
IGS69_RS11825	COG0438	transferase activity, transferring glycosyl groups
IGS69_RS11830	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IGS69_RS11925	COG1132	(ABC) transporter
IGS69_RS11940	COG4152	abc transporter atp-binding protein
IGS69_RS11945	COG1668	transmembrane transport
IGS69_RS11970	COG1476	TRANSCRIPTIONal
IGS69_RS11995	COG3962	Belongs to the TPP enzyme family
IGS69_RS12005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IGS69_RS12035	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IGS69_RS12040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IGS69_RS12050	COG1869	D-ribose catabolic process
IGS69_RS12055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IGS69_RS12065	COG1129	ABC transporter
IGS69_RS12070	COG1609	Transcriptional regulator
IGS69_RS12120	COG3385	transposase activity
IGS69_RS12130	COG0456	acetyltransferase
IGS69_RS12130	COG1846	Transcriptional regulator
IGS69_RS12145	COG0673	inositol 2-dehydrogenase activity
IGS69_RS12170	COG1472	Belongs to the glycosyl hydrolase 3 family
IGS69_RS12205	COG0028	Belongs to the TPP enzyme family
IGS69_RS12215	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IGS69_RS12230	COG1946	Acyl-CoA thioesterase
IGS69_RS12240	COG1309	transcriptional regulator
IGS69_RS12245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IGS69_RS12260	COG1960	acyl-CoA dehydrogenase activity
IGS69_RS12280	COG3486	L-lysine 6-monooxygenase (NADPH) activity
IGS69_RS12310	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IGS69_RS12320	COG0589	response to stress
IGS69_RS12330	COG4977	sequence-specific DNA binding
IGS69_RS12335	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IGS69_RS12370	COG0395	ABC-type sugar transport system, permease component
IGS69_RS12385	COG0745	RESPONSE REGULATOR receiver
IGS69_RS12410	COG0406	alpha-ribazole phosphatase activity
IGS69_RS12460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS69_RS12475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IGS69_RS12480	COG0154	amidase activity
IGS69_RS12490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS69_RS12495	COG0765	amino acid transport
IGS69_RS12500	COG0765	amino acid transport
IGS69_RS12505	COG1126	abc transporter atp-binding protein
IGS69_RS12525	COG3397	chitin binding
IGS69_RS12545	COG2186	Transcriptional regulator
IGS69_RS12590	COG0673	inositol 2-dehydrogenase activity
IGS69_RS12595	COG4702	Belongs to the UPF0303 family
IGS69_RS12605	COG0515	serine threonine protein kinase
IGS69_RS12615	COG0706	membrane insertase activity
IGS69_RS12690	COG2733	membrane
IGS69_RS12705	COG4555	ABC transporter
IGS69_RS12720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IGS69_RS12725	COG2076	Multidrug Resistance protein
IGS69_RS12755	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IGS69_RS12765	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IGS69_RS12770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IGS69_RS12775	COG1263	PTS System
IGS69_RS12780	COG1234	tRNA 3'-trailer cleavage
IGS69_RS12805	COG1113	amino acid transport
IGS69_RS12815	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IGS69_RS12825	COG1335	isochorismatase
IGS69_RS12860	COG0277	FAD linked oxidase domain protein
IGS69_RS12870	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IGS69_RS12880	COG1174	glycine betaine transport
IGS69_RS12890	COG1174	glycine betaine transport
IGS69_RS12895	COG1732	Glycine betaine
IGS69_RS12970	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IGS69_RS12975	COG0395	ABC-type sugar transport system, permease component
IGS69_RS12980	COG1175	transmembrane transport
IGS69_RS12995	COG1678	Uncharacterized ACR, COG1678
IGS69_RS13000	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IGS69_RS13005	COG0776	regulation of translation
IGS69_RS13015	COG3973	AAA domain
IGS69_RS13040	COG2223	nitrite transmembrane transporter activity
IGS69_RS13115	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IGS69_RS13120	COG0793	Belongs to the peptidase S41A family
IGS69_RS13130	COG2884	Cell division ATP-binding protein ftsE
IGS69_RS13145	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IGS69_RS13150	COG0515	serine threonine protein kinase
IGS69_RS13155	COG0515	serine threonine protein kinase
IGS69_RS13160	COG1674	ftsk spoiiie
IGS69_RS13170	COG1175	transmembrane transport
IGS69_RS13175	COG0395	ABC-type sugar transport system, permease component
IGS69_RS13180	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IGS69_RS13185	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IGS69_RS13190	COG1216	Glycosyl transferase, family 2
IGS69_RS13195	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IGS69_RS13205	COG1764	response to oxidative stress
IGS69_RS13210	COG1846	Transcriptional regulator
IGS69_RS13240	COG1134	teichoic acid transport
IGS69_RS13245	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IGS69_RS13250	COG1216	Glycosyl transferase, family 2
IGS69_RS13255	COG2902	Dehydrogenase
IGS69_RS13275	COG0653	protein targeting
IGS69_RS13285	COG3214	Protein conserved in bacteria
IGS69_RS13290	COG2197	response regulator
IGS69_RS13295	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IGS69_RS13305	COG0823	Involved in the tonB-independent uptake of proteins
IGS69_RS13310	COG5000	phosphorelay sensor kinase activity
IGS69_RS13310	COG5002	protein histidine kinase activity
IGS69_RS13315	COG0745	RESPONSE REGULATOR receiver
IGS69_RS13320	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IGS69_RS13340	COG0714	Associated with various cellular activities
IGS69_RS13380	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IGS69_RS13385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IGS69_RS13385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IGS69_RS13385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IGS69_RS13390	COG0681	Belongs to the peptidase S26 family
IGS69_RS13400	COG1482	cell wall glycoprotein biosynthetic process
IGS69_RS13410	COG2835	tetraacyldisaccharide 4'-kinase activity
IGS69_RS13415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IGS69_RS13420	COG1620	l-lactate permease
IGS69_RS13455	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IGS69_RS13460	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
IGS69_RS13460	COG0778	Nitroreductase
IGS69_RS13485	COG1316	TRANSCRIPTIONal
IGS69_RS13490	COG1316	TRANSCRIPTIONal
IGS69_RS13495	COG1316	TRANSCRIPTIONal
IGS69_RS13500	COG1316	TRANSCRIPTIONal
IGS69_RS13505	COG0577	efflux transmembrane transporter activity
IGS69_RS13505	COG1136	(ABC) transporter
IGS69_RS13510	COG1136	(ABC) transporter
IGS69_RS13535	COG1316	TRANSCRIPTIONal
IGS69_RS13545	COG1316	TRANSCRIPTIONal
IGS69_RS13555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IGS69_RS13610	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IGS69_RS13625	COG2205	protein histidine kinase activity
IGS69_RS13630	COG0745	RESPONSE REGULATOR receiver
IGS69_RS13635	COG3104	oligopeptide transport
IGS69_RS13655	COG1366	Belongs to the anti-sigma-factor antagonist family
IGS69_RS13660	COG1191	sigma factor activity
IGS69_RS13670	COG1228	amidohydrolase
IGS69_RS13685	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IGS69_RS13705	COG4221	oxidoreductase activity
IGS69_RS13720	COG2755	lipolytic protein G-D-S-L family
IGS69_RS13725	COG0183	Belongs to the thiolase family
IGS69_RS13760	COG1136	(ABC) transporter
IGS69_RS13765	COG0577	efflux transmembrane transporter activity
IGS69_RS13770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IGS69_RS13775	COG1252	NADH dehydrogenase
IGS69_RS13795	COG0148	phosphopyruvate hydratase activity
IGS69_RS13865	COG0577	efflux transmembrane transporter activity
IGS69_RS13870	COG1136	(ABC) transporter
IGS69_RS13875	COG0477	Major facilitator Superfamily
IGS69_RS13890	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IGS69_RS13925	COG4585	Histidine kinase
IGS69_RS13940	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IGS69_RS13945	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IGS69_RS13950	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IGS69_RS13955	COG0193	aminoacyl-tRNA hydrolase activity
IGS69_RS13965	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IGS69_RS13975	COG1309	transcriptional regulator
IGS69_RS13985	COG4106	trans-aconitate 2-methyltransferase activity
IGS69_RS13995	COG2197	response regulator
IGS69_RS14015	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IGS69_RS14055	COG0488	(ABC) transporter
IGS69_RS14060	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IGS69_RS14065	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IGS69_RS14070	COG3584	3D domain protein
IGS69_RS14070	COG3583	domain protein
IGS69_RS14075	COG0084	hydrolase, TatD family'
IGS69_RS14110	COG0310	cobalt ion transport
IGS69_RS14120	COG1122	ATPase activity
IGS69_RS14125	COG1846	Transcriptional regulator
IGS69_RS14130	COG1764	response to oxidative stress
IGS69_RS14135	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IGS69_RS14150	COG0442	prolyl-tRNA aminoacylation
IGS69_RS14180	COG2409	Drug exporters of the RND superfamily
IGS69_RS14190	COG4946	Tricorn protease homolog
IGS69_RS14190	COG0793	Belongs to the peptidase S41A family
IGS69_RS14205	COG2267	carboxylic ester hydrolase activity
IGS69_RS14210	COG2072	flavoprotein involved in K transport
IGS69_RS14225	COG0454	-acetyltransferase
IGS69_RS14250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IGS69_RS14255	COG0315	cyclic pyranopterin monophosphate synthase activity
IGS69_RS14255	COG0521	Mo-molybdopterin cofactor biosynthetic process
IGS69_RS14260	COG0315	cyclic pyranopterin monophosphate synthase activity
IGS69_RS14270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IGS69_RS14275	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IGS69_RS14300	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IGS69_RS14310	COG1970	mechanosensitive ion channel activity
IGS69_RS14340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IGS69_RS14340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IGS69_RS14340	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IGS69_RS14350	COG1349	DNA-binding transcription factor activity
IGS69_RS14355	COG0477	Major facilitator Superfamily
IGS69_RS14375	COG1247	-acetyltransferase
IGS69_RS14380	COG3384	dioxygenase
IGS69_RS14385	COG1846	Transcriptional regulator
IGS69_RS14405	COG1414	Transcriptional regulator
IGS69_RS14430	COG1902	pentaerythritol trinitrate reductase activity
IGS69_RS14435	COG3152	Membrane
IGS69_RS14455	COG2197	response regulator
IGS69_RS14475	COG2132	Multicopper oxidase
IGS69_RS14575	COG1846	Transcriptional regulator
IGS69_RS14590	COG0386	Belongs to the glutathione peroxidase family
IGS69_RS14610	COG1686	Belongs to the peptidase S11 family
IGS69_RS14670	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IGS69_RS14685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IGS69_RS14730	COG1012	belongs to the aldehyde dehydrogenase family
IGS69_RS14770	COG3903	Transcriptional regulator
IGS69_RS14770	COG3629	intracellular signal transduction
IGS69_RS14790	COG1024	Enoyl-CoA hydratase
IGS69_RS14800	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IGS69_RS14800	COG0515	serine threonine protein kinase
IGS69_RS14810	COG1309	transcriptional regulator
IGS69_RS14820	COG1960	acyl-CoA dehydrogenase activity
IGS69_RS14830	COG0259	pyridoxamine-phosphate oxidase activity
IGS69_RS14855	COG2072	flavoprotein involved in K transport
IGS69_RS14865	COG1024	Enoyl-CoA hydratase
IGS69_RS14875	COG2814	Major facilitator Superfamily
IGS69_RS14885	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IGS69_RS14890	COG1960	acyl-CoA dehydrogenase activity
IGS69_RS14895	COG1028	Short-chain dehydrogenase reductase Sdr
IGS69_RS14910	COG1960	acyl-CoA dehydrogenase activity
IGS69_RS14915	COG1960	acyl-CoA dehydrogenase activity
IGS69_RS14935	COG1366	Belongs to the anti-sigma-factor antagonist family
IGS69_RS14940	COG1595	DNA-templated transcription, initiation
IGS69_RS14990	COG0596	Alpha beta hydrolase
IGS69_RS14990	COG2945	thiolester hydrolase activity
IGS69_RS15000	COG4821	SIS domain
IGS69_RS15020	COG0259	pyridoxamine-phosphate oxidase activity
IGS69_RS15045	COG0318	PFAM AMP-dependent synthetase and ligase
IGS69_RS15060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IGS69_RS15085	COG0277	FAD linked oxidase domain protein
IGS69_RS15085	COG0247	lactate metabolic process
IGS69_RS15090	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IGS69_RS15095	COG0596	Alpha beta hydrolase
IGS69_RS15125	COG0667	Aldo Keto reductase
IGS69_RS15160	COG2252	PERMEase
IGS69_RS15175	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IGS69_RS15195	COG2814	Major facilitator Superfamily
IGS69_RS15205	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IGS69_RS15210	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IGS69_RS15215	COG1278	Cold shock
IGS69_RS15250	COG1061	Type III restriction enzyme res subunit
IGS69_RS15260	COG3973	AAA domain
IGS69_RS15295	COG1737	Transcriptional regulator
IGS69_RS15300	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IGS69_RS15345	COG0459	protein refolding
IGS69_RS15350	COG1278	Cold shock
IGS69_RS15365	COG0463	Glycosyl transferase, family 2
IGS69_RS15370	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
IGS69_RS15395	COG0402	S-adenosylhomocysteine deaminase activity
IGS69_RS15410	COG3300	MHYT domain
IGS69_RS15410	COG5001	Diguanylate cyclase
IGS69_RS15490	COG3842	ATPase activity
IGS69_RS15510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IGS69_RS15515	COG0215	cysteine-tRNA ligase activity
IGS69_RS15520	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IGS69_RS15525	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IGS69_RS15530	COG1329	Transcriptional regulator
IGS69_RS15545	COG5002	protein histidine kinase activity
IGS69_RS15565	COG4941	Belongs to the sigma-70 factor family
IGS69_RS15570	COG3795	YCII-related domain
IGS69_RS15575	COG2318	DinB family
IGS69_RS15605	COG3547	Transposase (IS116 IS110 IS902 family)
IGS69_RS15665	COG0588	phosphoglycerate mutase activity
IGS69_RS15685	COG2207	Transcriptional regulator
IGS69_RS15695	COG0438	transferase activity, transferring glycosyl groups
IGS69_RS15740	COG0714	Associated with various cellular activities
IGS69_RS15765	COG2226	methyltransferase
IGS69_RS15790	COG0546	phosphoglycolate phosphatase activity
IGS69_RS15810	COG2188	Transcriptional regulator
IGS69_RS15820	COG2186	Transcriptional regulator
IGS69_RS15825	COG4552	Acetyltransferase involved in intracellular survival and related
IGS69_RS15835	COG1490	D-aminoacyl-tRNA deacylase activity
IGS69_RS15850	COG3485	protocatechuate 3,4-dioxygenase
IGS69_RS15890	COG2897	thiosulfate sulfurtransferase activity
IGS69_RS15915	COG0745	RESPONSE REGULATOR receiver
IGS69_RS15920	COG1609	Transcriptional regulator
IGS69_RS15925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IGS69_RS15935	COG0745	RESPONSE REGULATOR receiver
IGS69_RS15955	COG0737	Belongs to the 5'-nucleotidase family
IGS69_RS15960	COG0456	acetyltransferase
IGS69_RS15980	COG1131	(ABC) transporter
IGS69_RS15995	COG1725	Transcriptional regulator
IGS69_RS16015	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IGS69_RS16025	COG0494	nUDIX hydrolase
IGS69_RS16025	COG0406	alpha-ribazole phosphatase activity
IGS69_RS16045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IGS69_RS16050	COG0306	phosphate transporter
IGS69_RS16060	COG1937	Protein conserved in bacteria
IGS69_RS16080	COG0277	FAD linked oxidase domain protein
IGS69_RS16085	COG0671	phosphoesterase, PA-phosphatase related
IGS69_RS16090	COG0739	heme binding
IGS69_RS16090	COG1196	nuclear chromosome segregation
IGS69_RS16090	COG0741	lytic transglycosylase activity
IGS69_RS16170	COG1252	NADH dehydrogenase
IGS69_RS16195	COG0579	oxidoreductase
IGS69_RS16210	COG0667	Aldo Keto reductase
IGS69_RS16225	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IGS69_RS16225	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IGS69_RS16235	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IGS69_RS16250	COG2172	sigma factor antagonist activity
IGS69_RS16255	COG1366	Belongs to the anti-sigma-factor antagonist family
IGS69_RS16260	COG1366	Belongs to the anti-sigma-factor antagonist family
IGS69_RS16275	COG1191	sigma factor activity
IGS69_RS16320	COG1643	Atp-dependent helicase
IGS69_RS16345	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IGS69_RS16355	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IGS69_RS16375	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IGS69_RS16380	COG0047	phosphoribosylformylglycinamidine synthase activity
IGS69_RS16385	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IGS69_RS16420	COG2197	response regulator
IGS69_RS16430	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IGS69_RS16445	COG0151	Belongs to the GarS family
IGS69_RS16555	COG0433	COG0433 Predicted ATPase
IGS69_RS16570	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IGS69_RS16605	COG1191	sigma factor activity
IGS69_RS16610	COG1191	sigma factor activity
IGS69_RS16650	COG3467	pyridoxamine 5'-phosphate
IGS69_RS16660	COG0477	Major facilitator Superfamily
IGS69_RS16675	COG2205	protein histidine kinase activity
IGS69_RS16680	COG0745	RESPONSE REGULATOR receiver
IGS69_RS16695	COG1846	Transcriptional regulator
IGS69_RS16730	COG1051	belongs to the nudix hydrolase family
IGS69_RS16775	COG0784	Response regulator, receiver
IGS69_RS16780	COG0318	PFAM AMP-dependent synthetase and ligase
IGS69_RS16785	COG1595	DNA-templated transcription, initiation
IGS69_RS16820	COG4249	Peptidase C14 caspase catalytic subunit p20
IGS69_RS16820	COG2319	Wd-40 repeat
IGS69_RS16890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IGS69_RS16925	COG0006	proline dipeptidase activity
IGS69_RS16930	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
IGS69_RS16935	COG0751	glycine-tRNA ligase activity
IGS69_RS16935	COG0752	glycyl-tRNA synthetase alpha subunit
IGS69_RS16955	COG1999	signal sequence binding
IGS69_RS16970	COG2837	iron assimilation
IGS69_RS16980	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IGS69_RS16985	COG0561	phosphatase activity
IGS69_RS17025	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
IGS69_RS17035	COG0561	phosphatase activity
IGS69_RS17040	COG0739	heme binding
IGS69_RS17040	COG0741	lytic transglycosylase activity
IGS69_RS17040	COG1196	nuclear chromosome segregation
IGS69_RS17045	COG4988	ABC transporter
IGS69_RS17050	COG1294	oxidase, subunit
IGS69_RS17055	COG1271	oxidase subunit
IGS69_RS17065	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IGS69_RS17070	COG1609	Transcriptional regulator
IGS69_RS17085	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IGS69_RS17110	COG0662	Cupin 2, conserved barrel domain protein
IGS69_RS17115	COG1950	PFAM Membrane protein of
IGS69_RS17120	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IGS69_RS17125	COG0626	cystathionine gamma-synthase activity
IGS69_RS17140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IGS69_RS17140	COG1017	nitric oxide dioxygenase activity
IGS69_RS17155	COG2814	Major facilitator Superfamily
IGS69_RS17170	COG0305	Participates in initiation and elongation during chromosome replication
IGS69_RS17175	COG0534	Mate efflux family protein
IGS69_RS17180	COG0359	binds to the 23S rRNA
IGS69_RS17185	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IGS69_RS17190	COG0629	single-stranded DNA binding
IGS69_RS17195	COG0360	Binds together with S18 to 16S ribosomal RNA
IGS69_RS17220	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IGS69_RS17245	COG0617	tRNA 3'-terminal CCA addition
IGS69_RS17260	COG0515	serine threonine protein kinase
IGS69_RS17260	COG2815	serine threonine protein kinase
IGS69_RS17265	COG1595	DNA-templated transcription, initiation
IGS69_RS17275	COG0492	ferredoxin-NADP+ reductase activity
IGS69_RS17280	COG3118	belongs to the thioredoxin family
IGS69_RS17295	COG1192	Involved in chromosome partitioning
IGS69_RS17300	COG0357	Ribosomal RNA small subunit methyltransferase G
IGS69_RS17310	COG0706	membrane insertase activity
IGS69_RS17315	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IGS69_RS17320	COG0594	ribonuclease P activity
IGS69_RS17330	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IGS69_RS17335	COG0592	DNA-directed DNA polymerase activity
IGS69_RS17340	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IGS69_RS17345	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IGS69_RS17350	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
IGS69_RS17355	COG0187	DNA topoisomerase II activity
IGS69_RS17360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IGS69_RS17395	COG0515	serine threonine protein kinase
IGS69_RS17420	COG0705	Rhomboid family
IGS69_RS17435	COG3764	Sortase (surface protein transpeptidase)
IGS69_RS17450	COG3764	Sortase (surface protein transpeptidase)
IGS69_RS17455	COG3764	Sortase (surface protein transpeptidase)
IGS69_RS17465	COG0515	serine threonine protein kinase
IGS69_RS17470	COG0768	penicillin binding
IGS69_RS17485	COG1716	ATPase activity
IGS69_RS17490	COG1716	ATPase activity
IGS69_RS17525	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IGS69_RS17530	COG0604	alcohol dehydrogenase
IGS69_RS17540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IGS69_RS17545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IGS69_RS17550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IGS69_RS17555	COG1028	Short-chain dehydrogenase reductase Sdr
IGS69_RS17560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IGS69_RS17580	COG0667	Aldo Keto reductase
IGS69_RS17585	COG0477	Major facilitator Superfamily
IGS69_RS17600	COG3629	intracellular signal transduction
IGS69_RS17625	COG0667	Aldo Keto reductase
IGS69_RS17640	COG2197	response regulator
IGS69_RS17710	COG1250	3-hydroxyacyl-CoA dehydrogenase
IGS69_RS17715	COG1309	transcriptional regulator
IGS69_RS17720	COG1522	sequence-specific DNA binding
IGS69_RS17750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IGS69_RS17765	COG1028	Short-chain dehydrogenase reductase Sdr
IGS69_RS17765	COG3321	synthase
IGS69_RS17765	COG0604	alcohol dehydrogenase
IGS69_RS17785	COG0515	serine threonine protein kinase
IGS69_RS17790	COG0515	serine threonine protein kinase
IGS69_RS17800	COG0022	dehydrogenase e1 component
IGS69_RS17805	COG0508	dehydrogenase complex catalyzes the overall conversion of
IGS69_RS17825	COG2890	protein-(glutamine-N5) methyltransferase activity
IGS69_RS17865	COG1362	aminopeptidase activity
IGS69_RS17870	COG1960	acyl-CoA dehydrogenase activity
IGS69_RS17890	COG0477	Major facilitator Superfamily
IGS69_RS17895	COG1741	Belongs to the pirin family
IGS69_RS17910	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IGS69_RS17950	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IGS69_RS17965	COG0583	DNA-binding transcription factor activity
IGS69_RS17985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGS69_RS18045	COG3547	Transposase (IS116 IS110 IS902 family)
IGS69_RS18060	COG0366	Alpha amylase catalytic
IGS69_RS18120	COG2267	carboxylic ester hydrolase activity
IGS69_RS18130	COG0513	Belongs to the DEAD box helicase family
IGS69_RS18135	COG1278	Cold shock
IGS69_RS18145	COG0475	glutathione-regulated potassium exporter activity
IGS69_RS18185	COG0513	Belongs to the DEAD box helicase family
IGS69_RS18190	COG1278	Cold shock
IGS69_RS18200	COG1802	Transcriptional regulator
IGS69_RS18220	COG3387	PFAM Glycoside hydrolase 15-related
IGS69_RS18285	COG3547	Transposase (IS116 IS110 IS902 family)
IGS69_RS18345	COG3547	Transposase (IS116 IS110 IS902 family)
IGS69_RS18355	COG2188	Transcriptional regulator
IGS69_RS18370	COG0717	Belongs to the dCTP deaminase family
IGS69_RS18375	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IGS69_RS18420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGS69_RS18430	COG0247	lactate metabolic process
IGS69_RS18430	COG2181	nitrate reductase activity
IGS69_RS18435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IGS69_RS18440	COG0443	Heat shock 70 kDa protein
IGS69_RS18445	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IGS69_RS18450	COG0484	heat shock protein binding
IGS69_RS18455	COG0789	Transcriptional regulator
IGS69_RS18460	COG4213	ABC transporter substrate-binding protein
IGS69_RS18485	COG0542	response to heat
IGS69_RS18520	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IGS69_RS18535	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IGS69_RS18545	COG0477	Major facilitator Superfamily
IGS69_RS18560	COG3844	kynureninase activity
IGS69_RS18580	COG4585	Histidine kinase
IGS69_RS18585	COG2197	response regulator
IGS69_RS18590	COG4585	Histidine kinase
IGS69_RS18595	COG2197	response regulator
IGS69_RS18600	COG2124	cytochrome p450
IGS69_RS18605	COG3559	Exporter of polyketide antibiotics
IGS69_RS18610	COG1131	(ABC) transporter
IGS69_RS18625	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IGS69_RS18640	COG1802	Transcriptional regulator
IGS69_RS18645	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IGS69_RS18650	COG0693	protein deglycase activity
IGS69_RS18670	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IGS69_RS18675	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IGS69_RS18700	COG1595	DNA-templated transcription, initiation
IGS69_RS18725	COG0701	Predicted permease
IGS69_RS18750	COG0277	FAD linked oxidase domain protein
IGS69_RS18795	COG0604	alcohol dehydrogenase
IGS69_RS18795	COG3321	synthase
IGS69_RS18795	COG1028	Short-chain dehydrogenase reductase Sdr
IGS69_RS18800	COG0477	Major facilitator Superfamily
IGS69_RS18805	COG2345	Transcriptional regulator
IGS69_RS18830	COG0367	asparagine synthase
IGS69_RS18835	COG3629	intracellular signal transduction
IGS69_RS18850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IGS69_RS18855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IGS69_RS18865	COG1028	Short-chain dehydrogenase reductase Sdr
IGS69_RS18870	COG1028	Short-chain dehydrogenase reductase Sdr
IGS69_RS18885	COG2124	cytochrome p450
IGS69_RS18895	COG3104	oligopeptide transport
IGS69_RS18955	COG1408	metallophosphoesterase
IGS69_RS18965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IGS69_RS18975	COG0003	Pfam Anion-transporting ATPase
IGS69_RS19000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IGS69_RS19025	COG2267	carboxylic ester hydrolase activity
IGS69_RS19035	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IGS69_RS19040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IGS69_RS19045	COG0288	reversible hydration of carbon dioxide
IGS69_RS19100	COG1111	helicase
IGS69_RS19100	COG1205	dead DEAH box helicase
IGS69_RS19105	COG1366	Belongs to the anti-sigma-factor antagonist family
IGS69_RS19110	COG2172	sigma factor antagonist activity
IGS69_RS19115	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IGS69_RS19125	COG2890	protein-(glutamine-N5) methyltransferase activity
IGS69_RS19135	COG1754	DNA topoisomerase type I activity
IGS69_RS19135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IGS69_RS19140	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IGS69_RS19160	COG3708	Transcriptional regulator
IGS69_RS19160	COG2207	Transcriptional regulator
IGS69_RS19170	COG3903	Transcriptional regulator
IGS69_RS19170	COG3629	intracellular signal transduction
IGS69_RS19175	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IGS69_RS19175	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IGS69_RS19185	COG1280	lysine exporter protein (LysE YggA)
IGS69_RS19205	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IGS69_RS19210	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IGS69_RS19215	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IGS69_RS19220	COG0254	rRNA binding
IGS69_RS19230	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IGS69_RS19255	COG1012	belongs to the aldehyde dehydrogenase family
IGS69_RS19260	COG2318	DinB family
IGS69_RS19280	COG0076	glutamate decarboxylase activity
IGS69_RS19290	COG0789	Transcriptional regulator
IGS69_RS19295	COG0393	Putative heavy-metal-binding
IGS69_RS19300	COG0586	Pfam SNARE associated Golgi protein
IGS69_RS19310	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IGS69_RS19315	COG2027	D-alanyl-D-alanine carboxypeptidase
IGS69_RS19325	COG0037	tRNA processing
IGS69_RS19340	COG0302	gtp cyclohydrolase
IGS69_RS19360	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IGS69_RS19400	COG0649	NAD binding
IGS69_RS19415	COG2197	response regulator
IGS69_RS19420	COG0640	Transcriptional regulator
IGS69_RS19430	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
IGS69_RS19440	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IGS69_RS19445	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IGS69_RS19455	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IGS69_RS19475	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IGS69_RS19500	COG0739	heme binding
IGS69_RS19520	COG0346	lactoylglutathione lyase activity
IGS69_RS19525	COG2205	protein histidine kinase activity
IGS69_RS19530	COG0745	RESPONSE REGULATOR receiver
IGS69_RS19540	COG1595	DNA-templated transcription, initiation
IGS69_RS19545	COG1194	a g-specific adenine glycosylase
IGS69_RS19555	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
IGS69_RS19575	COG0248	Ppx GppA phosphatase
IGS69_RS19580	COG1082	Xylose isomerase domain protein TIM barrel
IGS69_RS19585	COG1309	transcriptional regulator
IGS69_RS19590	COG0129	dihydroxy-acid dehydratase activity
IGS69_RS19600	COG4991	sh3 domain protein
IGS69_RS19620	COG0842	Transport permease protein
IGS69_RS19620	COG1129	ABC transporter
IGS69_RS19630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IGS69_RS19635	COG0180	Tryptophanyl-tRNA synthetase
IGS69_RS19665	COG0123	including yeast histone deacetylase and acetoin utilization protein
IGS69_RS19715	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IGS69_RS19720	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IGS69_RS19725	COG0181	hydroxymethylbilane synthase activity
IGS69_RS19730	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IGS69_RS19730	COG1648	precorrin-2 dehydrogenase activity
IGS69_RS19740	COG0113	porphobilinogen synthase activity
IGS69_RS19760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGS69_RS19770	COG0018	arginyl-trna synthetase
IGS69_RS19775	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
IGS69_RS19795	COG1690	Belongs to the RtcB family
IGS69_RS19810	COG1742	UPF0060 membrane protein
IGS69_RS19825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS69_RS19835	COG2205	protein histidine kinase activity
IGS69_RS19840	COG0366	Alpha amylase catalytic
IGS69_RS19855	COG1653	transport
IGS69_RS19860	COG1609	Transcriptional regulator
IGS69_RS19870	COG1174	glycine betaine transport
IGS69_RS19875	COG1174	glycine betaine transport
IGS69_RS19985	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IGS69_RS20000	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IGS69_RS20005	COG0406	alpha-ribazole phosphatase activity
IGS69_RS20015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IGS69_RS20020	COG0785	Cytochrome C biogenesis protein
IGS69_RS20025	COG1333	cytochrome c biogenesis protein
IGS69_RS20030	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IGS69_RS20100	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IGS69_RS20105	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IGS69_RS20115	COG0163	prenyltransferase activity
IGS69_RS20125	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IGS69_RS20130	COG1573	uracil-dna glycosylase
IGS69_RS20145	COG1301	dicarboxylic acid transport
IGS69_RS20150	COG1309	transcriptional regulator
IGS69_RS20180	COG4213	ABC transporter substrate-binding protein
IGS69_RS20185	COG2226	methyltransferase
IGS69_RS20195	COG1278	Cold shock
IGS69_RS20200	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IGS69_RS20210	COG1674	ftsk spoiiie
IGS69_RS20315	COG0726	polysaccharide deacetylase
IGS69_RS20320	COG1316	TRANSCRIPTIONal
IGS69_RS20345	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
IGS69_RS20420	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IGS69_RS20425	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IGS69_RS20440	COG2226	methyltransferase
IGS69_RS20460	COG0791	NLP P60 protein
IGS69_RS20460	COG1388	LysM domain
IGS69_RS20460	COG3103	Sh3 type 3 domain protein
IGS69_RS20470	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGS69_RS20475	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGS69_RS20480	COG0649	NAD binding
IGS69_RS20490	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IGS69_RS20495	COG1034	ATP synthesis coupled electron transport
IGS69_RS20500	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IGS69_RS20505	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGS69_RS20510	COG0839	Belongs to the complex I subunit 6 family
IGS69_RS20515	COG0713	ATP synthesis coupled electron transport
IGS69_RS20520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IGS69_RS20530	COG1007	ATP synthesis coupled electron transport
IGS69_RS20535	COG0514	ATP-dependent DNA helicase (RecQ)
IGS69_RS20540	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IGS69_RS20545	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IGS69_RS20565	COG2188	Transcriptional regulator
IGS69_RS20620	COG0561	phosphatase activity
IGS69_RS20630	COG0142	geranyltranstransferase activity
IGS69_RS20665	COG2234	aminopeptidase activity
IGS69_RS20665	COG4935	Belongs to the peptidase S8 family
IGS69_RS20680	COG1733	regulation of RNA biosynthetic process
IGS69_RS20695	COG0702	epimerase
IGS69_RS20700	COG1733	regulation of RNA biosynthetic process
IGS69_RS20705	COG1013	pyruvate-flavodoxin oxidoreductase activity
IGS69_RS20710	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IGS69_RS20710	COG0674	pyruvate-flavodoxin oxidoreductase activity
IGS69_RS20730	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGS69_RS20735	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGS69_RS20740	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGS69_RS20745	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IGS69_RS20750	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGS69_RS20755	COG0839	Belongs to the complex I subunit 6 family
IGS69_RS20760	COG0713	ATP synthesis coupled electron transport
IGS69_RS20765	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IGS69_RS20775	COG1007	ATP synthesis coupled electron transport
IGS69_RS20780	COG0501	Belongs to the peptidase M48B family
IGS69_RS20785	COG3304	Inner membrane component domain
IGS69_RS20795	COG2261	transglycosylase associated protein
IGS69_RS20800	COG1666	GTP binding
IGS69_RS20835	COG0702	epimerase
IGS69_RS20855	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IGS69_RS20860	COG2030	dehydratase
IGS69_RS20875	COG0477	Major facilitator Superfamily
IGS69_RS20885	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IGS69_RS20890	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IGS69_RS20895	COG0436	Aminotransferase
IGS69_RS20905	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IGS69_RS20910	COG0250	Participates in transcription elongation, termination and antitermination
IGS69_RS20915	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IGS69_RS20920	COG0081	regulation of translation
IGS69_RS20930	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IGS69_RS20935	COG0222	ribosome binding
IGS69_RS20940	COG0085	RNA polymerase activity
IGS69_RS20945	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IGS69_RS20955	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IGS69_RS20960	COG0049	tRNA binding
IGS69_RS20965	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IGS69_RS20970	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IGS69_RS21010	COG0051	transcription antitermination factor activity, RNA binding
IGS69_RS21015	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IGS69_RS21020	COG0088	Forms part of the polypeptide exit tunnel
IGS69_RS21025	COG0089	rRNA binding
IGS69_RS21030	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IGS69_RS21035	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IGS69_RS21040	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IGS69_RS21045	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IGS69_RS21050	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IGS69_RS21055	COG0255	Belongs to the universal ribosomal protein uL29 family
IGS69_RS21060	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IGS69_RS21065	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IGS69_RS21070	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IGS69_RS21075	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IGS69_RS21080	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IGS69_RS21085	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IGS69_RS21090	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IGS69_RS21095	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IGS69_RS21100	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IGS69_RS21105	COG1841	ribosomal large subunit assembly
IGS69_RS21110	COG0200	Binds to the 23S rRNA
IGS69_RS21120	COG0563	adenylate kinase activity
IGS69_RS21130	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IGS69_RS21135	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IGS69_RS21140	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IGS69_RS21145	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IGS69_RS21150	COG0202	RNA polymerase activity
IGS69_RS21155	COG0203	ribosomal protein L17
IGS69_RS21160	COG0101	tRNA pseudouridine synthase activity
IGS69_RS21175	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IGS69_RS21180	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IGS69_RS21185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IGS69_RS21195	COG1072	(Pantothenic acid kinase))
IGS69_RS21210	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IGS69_RS21220	COG0736	holo-[acyl-carrier-protein] synthase activity
IGS69_RS21235	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IGS69_RS21245	COG0802	atpase or kinase
IGS69_RS21260	COG0456	acetyltransferase
IGS69_RS21260	COG1214	PFAM Peptidase M22, glycoprotease
IGS69_RS21270	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IGS69_RS21285	COG1609	Transcriptional regulator
IGS69_RS21290	COG1316	TRANSCRIPTIONal
IGS69_RS21300	COG4941	Belongs to the sigma-70 factor family
IGS69_RS21310	COG0726	polysaccharide deacetylase
IGS69_RS21315	COG0726	polysaccharide deacetylase
IGS69_RS21320	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IGS69_RS21325	COG0459	protein refolding
IGS69_RS21345	COG4221	oxidoreductase activity
IGS69_RS21355	COG0583	DNA-binding transcription factor activity
IGS69_RS21370	COG1595	DNA-templated transcription, initiation
IGS69_RS21380	COG0516	GMP reductase activity
IGS69_RS21390	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IGS69_RS21405	COG2815	serine threonine protein kinase
IGS69_RS21405	COG0515	serine threonine protein kinase
IGS69_RS21410	COG0515	serine threonine protein kinase
IGS69_RS21420	COG0515	serine threonine protein kinase
IGS69_RS21425	COG0515	serine threonine protein kinase
IGS69_RS21430	COG1012	belongs to the aldehyde dehydrogenase family
IGS69_RS21455	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IGS69_RS21455	COG0519	Catalyzes the synthesis of GMP from XMP
IGS69_RS21500	COG2197	response regulator
IGS69_RS21505	COG0791	NLP P60 protein
IGS69_RS21530	COG0739	heme binding
IGS69_RS21540	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IGS69_RS21540	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IGS69_RS21555	COG0714	Associated with various cellular activities
IGS69_RS21565	COG3552	Protein containing von Willebrand factor type A (VWA) domain
IGS69_RS21575	COG0045	succinate-CoA ligase (ADP-forming) activity
IGS69_RS21605	COG0138	bifunctional purine biosynthesis protein purh
IGS69_RS21610	COG0515	serine threonine protein kinase
IGS69_RS21610	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IGS69_RS21620	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IGS69_RS21635	COG0039	L-malate dehydrogenase activity
IGS69_RS21640	COG1012	belongs to the aldehyde dehydrogenase family
IGS69_RS21650	COG0517	IMP dehydrogenase activity
IGS69_RS21650	COG4175	Glycine betaine
IGS69_RS21655	COG4176	ABC-type proline glycine betaine transport system permease component
IGS69_RS21670	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IGS69_RS21675	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IGS69_RS21680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGS69_RS21695	COG0754	glutathionylspermidine amidase activity
IGS69_RS21700	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IGS69_RS21705	COG0180	Tryptophanyl-tRNA synthetase
IGS69_RS21725	COG0671	phosphoesterase, PA-phosphatase related
IGS69_RS21740	COG1295	ribonuclease BN
IGS69_RS21745	COG1686	Belongs to the peptidase S11 family
IGS69_RS21755	COG1408	metallophosphoesterase
IGS69_RS21760	COG1309	transcriptional regulator
IGS69_RS21795	COG1053	succinate dehydrogenase
IGS69_RS21805	COG2009	succinate dehydrogenase
IGS69_RS21865	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IGS69_RS21865	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IGS69_RS21880	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IGS69_RS21890	COG1216	Glycosyl transferase, family 2
IGS69_RS21905	COG2089	acid synthase
IGS69_RS21920	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IGS69_RS21920	COG1473	amidohydrolase
IGS69_RS21925	COG1744	ABC transporter substrate-binding protein PnrA-like
IGS69_RS21930	COG1744	ABC transporter substrate-binding protein PnrA-like
IGS69_RS21935	COG3845	ABC transporter
IGS69_RS21945	COG1079	Belongs to the binding-protein-dependent transport system permease family
IGS69_RS21980	COG2814	Major facilitator Superfamily
IGS69_RS21985	COG0583	DNA-binding transcription factor activity
IGS69_RS21995	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IGS69_RS22020	COG2205	protein histidine kinase activity
IGS69_RS22025	COG0745	RESPONSE REGULATOR receiver
IGS69_RS22030	COG1595	DNA-templated transcription, initiation
IGS69_RS22045	COG1012	belongs to the aldehyde dehydrogenase family
IGS69_RS22050	COG1012	belongs to the aldehyde dehydrogenase family
IGS69_RS22070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IGS69_RS22095	COG4770	biotin carboxylase activity
IGS69_RS22105	COG0424	maF-like protein
IGS69_RS22115	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IGS69_RS22125	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IGS69_RS22135	COG1024	Enoyl-CoA hydratase
IGS69_RS22145	COG2986	histidine ammonia-lyase
IGS69_RS22170	COG1136	(ABC) transporter
IGS69_RS22175	COG1404	Belongs to the peptidase S8 family
IGS69_RS22190	COG1064	alcohol dehydrogenase
IGS69_RS22215	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IGS69_RS22235	COG1595	DNA-templated transcription, initiation
IGS69_RS22240	COG2255	four-way junction helicase activity
IGS69_RS22245	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IGS69_RS22260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IGS69_RS22270	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IGS69_RS22280	COG3547	Transposase (IS116 IS110 IS902 family)
IGS69_RS22300	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IGS69_RS22320	COG1331	Highly conserved protein containing a thioredoxin domain
IGS69_RS22350	COG1309	transcriptional regulator
IGS69_RS22360	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
IGS69_RS22410	COG0436	Aminotransferase
IGS69_RS22425	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IGS69_RS22440	COG1414	Transcriptional regulator
IGS69_RS22445	COG0251	oxidation-reduction process
IGS69_RS22450	COG2610	gluconate transmembrane transporter activity
IGS69_RS22525	COG2894	cell division
IGS69_RS22560	COG2197	response regulator
IGS69_RS22620	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IGS69_RS22625	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IGS69_RS22640	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IGS69_RS22645	COG0450	alkyl hydroperoxide reductase
IGS69_RS22660	COG1136	(ABC) transporter
IGS69_RS22680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IGS69_RS22695	COG0114	fumarate hydratase activity
IGS69_RS22700	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IGS69_RS22700	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IGS69_RS22725	COG0778	Nitroreductase
IGS69_RS22730	COG1722	exodeoxyribonuclease VII activity
IGS69_RS22735	COG1570	exodeoxyribonuclease VII activity
IGS69_RS22740	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IGS69_RS22755	COG0012	GTP binding
IGS69_RS22800	COG2226	methyltransferase
IGS69_RS22805	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
IGS69_RS22825	COG0142	geranyltranstransferase activity
IGS69_RS22835	COG0702	epimerase
IGS69_RS22850	COG4585	Histidine kinase
IGS69_RS22900	COG1053	succinate dehydrogenase
IGS69_RS22920	COG1217	gtp-binding protein TYPA
IGS69_RS22930	COG0747	negative chemotaxis
IGS69_RS22935	COG0601	transmembrane transport
IGS69_RS22940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS69_RS22945	COG0444	Belongs to the ABC transporter superfamily
IGS69_RS22950	COG4608	Belongs to the ABC transporter superfamily
IGS69_RS22965	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IGS69_RS23010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGS69_RS23020	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IGS69_RS23035	COG1024	Enoyl-CoA hydratase
IGS69_RS23055	COG1595	DNA-templated transcription, initiation
IGS69_RS23065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IGS69_RS23070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IGS69_RS23105	COG0598	Magnesium transport protein CorA
IGS69_RS23115	COG2814	Major facilitator Superfamily
IGS69_RS23125	COG0613	PHP domain protein
IGS69_RS23130	COG2095	MarC family integral membrane protein
IGS69_RS23135	COG1864	DNA RNA non-specific endonuclease
IGS69_RS23135	COG3591	Belongs to the peptidase S1B family
IGS69_RS23145	COG1432	Conserved Protein
IGS69_RS23225	COG0596	Alpha beta hydrolase
IGS69_RS23230	COG0596	Alpha beta hydrolase
IGS69_RS23250	COG0210	DNA helicase
IGS69_RS23255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGS69_RS23295	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IGS69_RS23350	COG3480	Lon protease (S16) C-terminal proteolytic domain
IGS69_RS23360	COG1615	UPF0182 protein
IGS69_RS23385	COG0753	catalase activity
IGS69_RS23395	COG0483	inositol monophosphate 1-phosphatase activity
IGS69_RS23430	COG1162	GTPase activity
IGS69_RS23435	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IGS69_RS23445	COG2135	peptidase activity
IGS69_RS23455	COG1595	DNA-templated transcription, initiation
IGS69_RS23460	COG5662	AntiSigma factor
IGS69_RS23465	COG2199	diguanylate cyclase activity
IGS69_RS23465	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IGS69_RS23480	COG0242	peptide deformylase activity
IGS69_RS23490	COG2124	cytochrome p450
IGS69_RS23530	COG2188	Transcriptional regulator
IGS69_RS23535	COG2182	Extracellular solute-binding protein
IGS69_RS23540	COG1175	transmembrane transport
IGS69_RS23545	COG0395	ABC-type sugar transport system, permease component
IGS69_RS23550	COG1472	Belongs to the glycosyl hydrolase 3 family
IGS69_RS23555	COG0363	glucosamine-6-phosphate deaminase activity
IGS69_RS23560	COG1028	Short-chain dehydrogenase reductase Sdr
IGS69_RS23565	COG1309	transcriptional regulator
IGS69_RS23580	COG1597	lipid kinase activity
IGS69_RS23615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IGS69_RS23620	COG0142	geranyltranstransferase activity
IGS69_RS23625	COG0456	acetyltransferase
IGS69_RS23645	COG4941	Belongs to the sigma-70 factor family
IGS69_RS23680	COG4106	trans-aconitate 2-methyltransferase activity
IGS69_RS23685	COG1126	abc transporter atp-binding protein
IGS69_RS23700	COG0281	malic enzyme
IGS69_RS23705	COG0604	alcohol dehydrogenase
IGS69_RS23740	COG0508	dehydrogenase complex catalyzes the overall conversion of
IGS69_RS23740	COG0567	Dehydrogenase, E1 component
IGS69_RS23745	COG2205	protein histidine kinase activity
IGS69_RS23750	COG0745	RESPONSE REGULATOR receiver
IGS69_RS23770	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IGS69_RS23810	COG3883	PFAM NLP P60 protein
IGS69_RS23810	COG0791	NLP P60 protein
IGS69_RS23820	COG1309	transcriptional regulator
IGS69_RS23855	COG2205	protein histidine kinase activity
IGS69_RS23875	COG1793	dna ligase
IGS69_RS23875	COG3285	dna ligase
IGS69_RS23880	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IGS69_RS23885	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IGS69_RS24045	COG0018	arginyl-trna synthetase
IGS69_RS24050	COG0019	diaminopimelate decarboxylase activity
IGS69_RS24055	COG0460	homoserine dehydrogenase
IGS69_RS24060	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IGS69_RS24065	COG0083	homoserine kinase activity
IGS69_RS24085	COG0254	rRNA binding
IGS69_RS24090	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IGS69_RS24095	COG2890	protein-(glutamine-N5) methyltransferase activity
IGS69_RS24105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IGS69_RS24110	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IGS69_RS24115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IGS69_RS24130	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IGS69_RS24135	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IGS69_RS24140	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IGS69_RS24145	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IGS69_RS24150	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IGS69_RS24155	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IGS69_RS24160	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IGS69_RS24175	COG2197	response regulator
IGS69_RS24180	COG4585	Histidine kinase
IGS69_RS24195	COG1250	3-hydroxyacyl-CoA dehydrogenase
IGS69_RS24210	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
IGS69_RS24245	COG1131	(ABC) transporter
IGS69_RS24265	COG0183	Belongs to the thiolase family
IGS69_RS24280	COG0745	RESPONSE REGULATOR receiver
IGS69_RS24330	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IGS69_RS24330	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IGS69_RS24365	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IGS69_RS24370	COG0857	belongs to the CobB CobQ family
IGS69_RS24370	COG0280	phosphate acetyltransferase
IGS69_RS24375	COG0205	6-phosphofructokinase activity
IGS69_RS24390	COG0395	ABC-type sugar transport system, permease component
IGS69_RS24395	COG1175	transmembrane transport
IGS69_RS24405	COG4565	transcriptional regulatory protein
IGS69_RS24410	COG3290	protein histidine kinase activity
IGS69_RS24425	COG0477	Major facilitator Superfamily
IGS69_RS24445	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IGS69_RS24450	COG3281	Trehalose synthase
IGS69_RS24460	COG0366	Alpha amylase catalytic
IGS69_RS24470	COG0058	SHG alpha-glucan phosphorylase activity
IGS69_RS24490	COG1132	(ABC) transporter
IGS69_RS24495	COG1132	(ABC) transporter
IGS69_RS24500	COG1132	(ABC) transporter
IGS69_RS24505	COG1132	(ABC) transporter
IGS69_RS24545	COG0789	Transcriptional regulator
IGS69_RS24555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IGS69_RS24560	COG3757	hydrolase, family 25
IGS69_RS24560	COG3409	Peptidoglycan-binding domain 1 protein
IGS69_RS24565	COG0477	Major facilitator Superfamily
IGS69_RS24570	COG1760	l-serine dehydratase
IGS69_RS24575	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IGS69_RS24580	COG0509	glycine decarboxylation via glycine cleavage system
IGS69_RS24585	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IGS69_RS24605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS69_RS24615	COG0601	transmembrane transport
IGS69_RS24625	COG4608	Belongs to the ABC transporter superfamily
IGS69_RS24630	COG2860	membrane
IGS69_RS24640	COG1309	transcriptional regulator
IGS69_RS24665	COG0482	sulfurtransferase activity
IGS69_RS24685	COG1611	Belongs to the LOG family
IGS69_RS24690	COG4221	oxidoreductase activity
IGS69_RS24700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IGS69_RS24715	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IGS69_RS24720	COG0154	amidase activity
IGS69_RS24730	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IGS69_RS24745	COG2409	Drug exporters of the RND superfamily
IGS69_RS24760	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IGS69_RS24760	COG1672	PFAM Archaeal ATPase
IGS69_RS24770	COG2133	pyrroloquinoline quinone binding
IGS69_RS24775	COG0667	Aldo Keto reductase
IGS69_RS24785	COG5001	Diguanylate cyclase
IGS69_RS24795	COG0440	acetolactate synthase activity
IGS69_RS24800	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IGS69_RS24805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IGS69_RS24810	COG3835	regulator
IGS69_RS24815	COG0506	proline dehydrogenase activity
IGS69_RS24820	COG1012	belongs to the aldehyde dehydrogenase family
IGS69_RS24835	COG0473	3-isopropylmalate dehydrogenase activity
IGS69_RS24840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IGS69_RS24850	COG0832	Belongs to the urease beta subunit family
IGS69_RS24850	COG0831	urea catabolic process
IGS69_RS24855	COG0804	urea catabolic process
IGS69_RS24860	COG2957	Belongs to the agmatine deiminase family
IGS69_RS24875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IGS69_RS24915	COG2353	YceI-like domain
IGS69_RS24920	COG4221	oxidoreductase activity
IGS69_RS24925	COG5492	domain, Protein
IGS69_RS24930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IGS69_RS24950	COG2018	Roadblock/LC7 domain
IGS69_RS24970	COG2018	Roadblock/LC7 domain
IGS69_RS24975	COG5002	protein histidine kinase activity
IGS69_RS24985	COG0179	Fumarylacetoacetate (FAA) hydrolase
IGS69_RS24990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IGS69_RS25025	COG1414	Transcriptional regulator
IGS69_RS25030	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IGS69_RS25035	COG0066	3-isopropylmalate dehydratase activity
IGS69_RS25045	COG0776	regulation of translation
IGS69_RS25055	COG1920	GTP binding
IGS69_RS25065	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IGS69_RS25070	COG1181	Belongs to the D-alanine--D-alanine ligase family
IGS69_RS25090	COG0351	phosphomethylpyrimidine kinase
IGS69_RS25095	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IGS69_RS25100	COG1461	Dihydroxyacetone kinase
IGS69_RS25110	COG0326	Molecular chaperone. Has ATPase activity
IGS69_RS25120	COG0742	ribosomal rna small subunit methyltransferase
IGS69_RS25125	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IGS69_RS25140	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IGS69_RS25145	COG0571	ribonuclease III activity
IGS69_RS25150	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IGS69_RS25155	COG1733	regulation of RNA biosynthetic process
IGS69_RS25165	COG2340	Cysteine-rich secretory protein family
IGS69_RS25170	COG1254	Belongs to the acylphosphatase family
IGS69_RS25180	COG1196	nuclear chromosome segregation
IGS69_RS25185	COG0477	Major facilitator Superfamily
IGS69_RS25225	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IGS69_RS25250	COG0228	four-way junction DNA binding
IGS69_RS25255	COG1837	Belongs to the UPF0109 family
IGS69_RS25260	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IGS69_RS25265	COG0336	Belongs to the RNA methyltransferase TrmD family
IGS69_RS25270	COG0335	large ribosomal subunit rRNA binding
IGS69_RS25275	COG0681	Belongs to the peptidase S26 family
IGS69_RS25285	COG0681	Belongs to the peptidase S26 family
IGS69_RS25295	COG0494	nUDIX hydrolase
IGS69_RS25305	COG0792	nuclease activity
IGS69_RS25320	COG1191	sigma factor activity
IGS69_RS25335	COG0052	Belongs to the universal ribosomal protein uS2 family
IGS69_RS25340	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IGS69_RS25345	COG0528	UMP kinase activity
IGS69_RS25350	COG0233	cytoplasmic translational termination
IGS69_RS25355	COG0575	Belongs to the CDS family
IGS69_RS25375	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IGS69_RS25385	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IGS69_RS25390	COG3842	ATPase activity
IGS69_RS25420	COG1136	(ABC) transporter
IGS69_RS25425	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IGS69_RS25435	COG1012	belongs to the aldehyde dehydrogenase family
IGS69_RS25460	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IGS69_RS25490	COG3842	ATPase activity
IGS69_RS25495	COG1176	ABC-type spermidine putrescine transport system, permease component I
IGS69_RS25500	COG1177	transmembrane transport
IGS69_RS25505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGS69_RS25530	COG2508	Transcriptional regulator
IGS69_RS25530	COG2508	Transcriptional regulator
IGS69_RS25535	COG1012	belongs to the aldehyde dehydrogenase family
IGS69_RS25545	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IGS69_RS25550	COG0750	zinc metalloprotease
IGS69_RS25555	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IGS69_RS25570	COG0442	prolyl-tRNA aminoacylation
IGS69_RS25590	COG0779	Required for maturation of 30S ribosomal subunits
IGS69_RS25605	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IGS69_RS25615	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IGS69_RS25620	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IGS69_RS25645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS69_RS25650	COG0601	transmembrane transport
IGS69_RS25655	COG0747	negative chemotaxis
IGS69_RS25660	COG0455	bacterial-type flagellum organization
IGS69_RS25675	COG3266	domain, Protein
IGS69_RS25680	COG1404	Belongs to the peptidase S8 family
IGS69_RS25730	COG1674	ftsk spoiiie
IGS69_RS25745	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IGS69_RS25750	COG1185	polyribonucleotide nucleotidyltransferase activity
IGS69_RS25755	COG0612	Peptidase, M16
IGS69_RS25760	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IGS69_RS25780	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
IGS69_RS25785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IGS69_RS25790	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IGS69_RS25820	COG2208	phosphoserine phosphatase activity
IGS69_RS25820	COG2770	Histidine kinase
IGS69_RS25825	COG0784	Response regulator, receiver
IGS69_RS25825	COG2205	protein histidine kinase activity
IGS69_RS25835	COG1674	ftsk spoiiie
IGS69_RS25845	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IGS69_RS25855	COG1546	Belongs to the CinA family
IGS69_RS25855	COG1058	Belongs to the CinA family
IGS69_RS25860	COG1396	sequence-specific DNA binding
IGS69_RS25865	COG0783	Belongs to the Dps family
IGS69_RS25870	COG1028	Short-chain dehydrogenase reductase Sdr
IGS69_RS25875	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IGS69_RS25880	COG1201	RNA secondary structure unwinding
IGS69_RS25910	COG0628	permease
IGS69_RS25915	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IGS69_RS25925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IGS69_RS25940	COG0765	amino acid transport
IGS69_RS25945	COG0765	amino acid transport
IGS69_RS25950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS69_RS25955	COG1126	abc transporter atp-binding protein
IGS69_RS25960	COG0745	RESPONSE REGULATOR receiver
IGS69_RS25965	COG2205	protein histidine kinase activity
IGS69_RS25970	COG2358	TRAP transporter, solute receptor (TAXI family
IGS69_RS25990	COG3851	Histidine kinase
IGS69_RS25995	COG2197	response regulator
IGS69_RS26000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IGS69_RS26020	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IGS69_RS26030	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IGS69_RS26035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IGS69_RS26045	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IGS69_RS26080	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IGS69_RS26085	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IGS69_RS26090	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IGS69_RS26125	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IGS69_RS26160	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IGS69_RS26165	COG2186	Transcriptional regulator
IGS69_RS26170	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IGS69_RS26225	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
IGS69_RS26240	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IGS69_RS26255	COG0210	DNA helicase
IGS69_RS26270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IGS69_RS26275	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IGS69_RS26275	COG0515	serine threonine protein kinase
IGS69_RS26320	COG0187	DNA topoisomerase II activity
IGS69_RS26330	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IGS69_RS26335	COG4565	transcriptional regulatory protein
IGS69_RS26340	COG3290	protein histidine kinase activity
IGS69_RS26355	COG0372	Belongs to the citrate synthase family
IGS69_RS26375	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IGS69_RS26380	COG0612	Peptidase, M16
IGS69_RS26395	COG1802	Transcriptional regulator
IGS69_RS26400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IGS69_RS26420	COG1435	thymidine kinase activity
IGS69_RS26450	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IGS69_RS26465	COG0745	RESPONSE REGULATOR receiver
IGS69_RS26470	COG2205	protein histidine kinase activity
IGS69_RS26495	COG0756	dUTP diphosphatase activity
IGS69_RS26535	COG0569	domain protein
IGS69_RS26540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IGS69_RS26545	COG0531	amino acid
IGS69_RS26550	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IGS69_RS26555	COG0563	adenylate kinase activity
IGS69_RS26565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IGS69_RS26575	COG1028	Short-chain dehydrogenase reductase Sdr
IGS69_RS26595	COG0535	radical SAM domain protein
IGS69_RS26610	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IGS69_RS26625	COG2197	response regulator
IGS69_RS26630	COG4585	Histidine kinase
IGS69_RS26645	COG1012	belongs to the aldehyde dehydrogenase family
IGS69_RS26660	COG4569	acetaldehyde dehydrogenase (acetylating) activity
IGS69_RS26685	COG2084	Dehydrogenase
IGS69_RS26725	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IGS69_RS26755	COG0243	molybdopterin cofactor binding
IGS69_RS26760	COG1799	cell septum assembly
IGS69_RS26765	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IGS69_RS26790	COG2226	methyltransferase
IGS69_RS26795	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IGS69_RS26805	COG2255	four-way junction helicase activity
IGS69_RS26835	COG2235	arginine
IGS69_RS26840	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IGS69_RS26845	COG0531	amino acid
IGS69_RS26855	COG1024	Enoyl-CoA hydratase
IGS69_RS26865	COG1595	DNA-templated transcription, initiation
IGS69_RS26870	COG1252	NADH dehydrogenase
IGS69_RS26885	COG0725	ABC transporter, periplasmic molybdate-binding protein
IGS69_RS26930	COG0601	transmembrane transport
IGS69_RS26935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS69_RS26940	COG0444	Belongs to the ABC transporter superfamily
IGS69_RS26945	COG1124	(ABC) transporter
IGS69_RS26965	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IGS69_RS26970	COG0019	diaminopimelate decarboxylase activity
IGS69_RS27000	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IGS69_RS27005	COG3547	Transposase (IS116 IS110 IS902 family)
IGS69_RS27060	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IGS69_RS27080	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IGS69_RS27090	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IGS69_RS27100	COG4214	carbohydrate transport
IGS69_RS27110	COG4213	ABC transporter substrate-binding protein
IGS69_RS27135	COG1653	transport
IGS69_RS27140	COG1175	transmembrane transport
IGS69_RS27145	COG0395	ABC-type sugar transport system, permease component
IGS69_RS27150	COG1940	carbohydrate kinase activity
IGS69_RS27155	COG4213	ABC transporter substrate-binding protein
IGS69_RS27165	COG4214	carbohydrate transport
IGS69_RS27170	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IGS69_RS27175	COG0531	amino acid
IGS69_RS27190	COG1250	3-hydroxyacyl-CoA dehydrogenase
IGS69_RS27190	COG1024	Enoyl-CoA hydratase
IGS69_RS27195	COG0183	Belongs to the thiolase family
IGS69_RS27200	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IGS69_RS27215	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IGS69_RS27225	COG0446	pyridine nucleotide-disulphide oxidoreductase
IGS69_RS27235	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IGS69_RS27240	COG3253	May function as heme-dependent peroxidase
IGS69_RS27255	COG1012	belongs to the aldehyde dehydrogenase family
IGS69_RS27270	COG3220	belongs to the UPF0276 family
IGS69_RS27275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IGS69_RS27295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGS69_RS27295	COG0723	plastoquinol--plastocyanin reductase activity
IGS69_RS27315	COG0330	HflC and HflK could
IGS69_RS27345	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IGS69_RS27350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IGS69_RS27380	COG0745	RESPONSE REGULATOR receiver
IGS69_RS27385	COG2205	protein histidine kinase activity
IGS69_RS27395	COG1174	glycine betaine transport
IGS69_RS27400	COG1174	glycine betaine transport
IGS69_RS27460	COG1404	Belongs to the peptidase S8 family
IGS69_RS27465	COG1309	transcriptional regulator
IGS69_RS27555	COG1175	transmembrane transport
IGS69_RS27595	COG2409	Drug exporters of the RND superfamily
IGS69_RS27620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IGS69_RS27625	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IGS69_RS27650	COG0529	Catalyzes the synthesis of activated sulfate
IGS69_RS27655	COG0175	sulfate reduction
IGS69_RS27685	COG1960	acyl-CoA dehydrogenase activity
IGS69_RS27700	COG4977	sequence-specific DNA binding
IGS69_RS27700	COG1917	Cupin 2, conserved barrel domain protein
IGS69_RS27750	COG2040	homocysteine
IGS69_RS27795	COG0395	ABC-type sugar transport system, permease component
IGS69_RS27800	COG1175	transmembrane transport
IGS69_RS27825	COG0277	FAD linked oxidase domain protein
IGS69_RS27850	COG1162	GTPase activity
IGS69_RS27860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IGS69_RS27875	COG0028	Belongs to the TPP enzyme family
IGS69_RS27905	COG1802	Transcriptional regulator
IGS69_RS27915	COG3835	regulator
IGS69_RS27930	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IGS69_RS27935	COG2252	PERMEase
IGS69_RS27940	COG3608	succinylglutamate desuccinylase aspartoacylase
IGS69_RS27940	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IGS69_RS27955	COG2192	nodulation
IGS69_RS27965	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IGS69_RS27980	COG0438	transferase activity, transferring glycosyl groups
IGS69_RS27985	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IGS69_RS27990	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IGS69_RS27990	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IGS69_RS28030	COG0477	Major facilitator Superfamily
IGS69_RS28035	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IGS69_RS28040	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IGS69_RS28050	COG0137	argininosuccinate synthase activity
IGS69_RS28105	COG0745	RESPONSE REGULATOR receiver
IGS69_RS28110	COG5002	protein histidine kinase activity
IGS69_RS28125	COG0456	acetyltransferase
IGS69_RS28125	COG1846	Transcriptional regulator
IGS69_RS28130	COG1335	isochorismatase
IGS69_RS28150	COG2197	response regulator
IGS69_RS28155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IGS69_RS28160	COG0318	PFAM AMP-dependent synthetase and ligase
IGS69_RS28175	COG3960	tartronate-semialdehyde synthase activity
IGS69_RS28190	COG2084	Dehydrogenase
IGS69_RS28195	COG3622	Belongs to the hyi family
IGS69_RS28245	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IGS69_RS28280	COG2351	hydroxyisourate hydrolase activity
IGS69_RS28295	COG2233	PERMEase
IGS69_RS28325	COG0436	Aminotransferase
IGS69_RS28330	COG1733	regulation of RNA biosynthetic process
IGS69_RS28340	COG2304	oxidoreductase activity
IGS69_RS28380	COG1120	ATPase activity
IGS69_RS28395	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IGS69_RS28410	COG1414	Transcriptional regulator
IGS69_RS28415	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IGS69_RS28420	COG4266	Belongs to the allantoicase family
IGS69_RS28425	COG1028	Short-chain dehydrogenase reductase Sdr
IGS69_RS28445	COG0673	inositol 2-dehydrogenase activity
IGS69_RS28450	COG2188	Transcriptional regulator
IGS69_RS28455	COG1940	carbohydrate kinase activity
IGS69_RS28465	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IGS69_RS28475	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IGS69_RS28480	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IGS69_RS28500	COG1126	abc transporter atp-binding protein
IGS69_RS28515	COG0405	Gamma-glutamyltransferase
IGS69_RS28520	COG0542	response to heat
IGS69_RS28545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IGS69_RS28560	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IGS69_RS28565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS69_RS28570	COG1953	Uracil, thiamine, allantoin
IGS69_RS28585	COG0483	inositol monophosphate 1-phosphatase activity
IGS69_RS28595	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IGS69_RS28605	COG2814	Major facilitator Superfamily
IGS69_RS28615	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IGS69_RS28630	COG1414	Transcriptional regulator
IGS69_RS28640	COG1063	alcohol dehydrogenase
IGS69_RS28660	COG2271	Major facilitator Superfamily
IGS69_RS28665	COG0121	glutamine amidotransferase
IGS69_RS28695	COG0640	Transcriptional regulator
IGS69_RS28705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IGS69_RS28710	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IGS69_RS28725	COG1929	Belongs to the glycerate kinase type-1 family
IGS69_RS28735	COG0688	phosphatidylethanolamine metabolic process
IGS69_RS28755	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IGS69_RS28755	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IGS69_RS28760	COG0604	alcohol dehydrogenase
IGS69_RS28770	COG1250	3-hydroxyacyl-CoA dehydrogenase
IGS69_RS28790	COG0596	Alpha beta hydrolase
IGS69_RS28810	COG1366	Belongs to the anti-sigma-factor antagonist family
IGS69_RS28810	COG2208	phosphoserine phosphatase activity
IGS69_RS28810	COG2172	sigma factor antagonist activity
IGS69_RS28815	COG2226	methyltransferase
IGS69_RS28820	COG2362	D-Aminopeptidase
IGS69_RS28825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGS69_RS28835	COG1619	proteins homologs of microcin C7 resistance protein MccF
IGS69_RS28845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IGS69_RS28870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS69_RS28885	COG1793	dna ligase
IGS69_RS28885	COG3285	dna ligase
IGS69_RS28950	COG0488	(ABC) transporter
IGS69_RS28960	COG0693	protein deglycase activity
IGS69_RS28980	COG0028	Belongs to the TPP enzyme family
IGS69_RS29040	COG0443	Heat shock 70 kDa protein
IGS69_RS29045	COG0702	epimerase
IGS69_RS29050	COG1733	regulation of RNA biosynthetic process
IGS69_RS29075	COG2154	pterin-4-alpha-carbinolamine dehydratase
IGS69_RS29080	COG4106	trans-aconitate 2-methyltransferase activity
IGS69_RS29080	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IGS69_RS29090	COG0656	L-ascorbic acid biosynthetic process
IGS69_RS29120	COG1063	alcohol dehydrogenase
IGS69_RS29130	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IGS69_RS29140	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IGS69_RS29145	COG3383	formate dehydrogenase (NAD+) activity
IGS69_RS29150	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IGS69_RS29165	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IGS69_RS29175	COG1940	carbohydrate kinase activity
IGS69_RS29180	COG1129	ABC transporter
IGS69_RS29185	COG1172	Belongs to the binding-protein-dependent transport system permease family
IGS69_RS29195	COG0673	inositol 2-dehydrogenase activity
IGS69_RS29215	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IGS69_RS29250	COG2223	nitrite transmembrane transporter activity
IGS69_RS29260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IGS69_RS29270	COG0045	succinate-CoA ligase (ADP-forming) activity
IGS69_RS29280	COG1012	belongs to the aldehyde dehydrogenase family
IGS69_RS29300	COG2018	Roadblock/LC7 domain
IGS69_RS29325	COG1177	transmembrane transport
IGS69_RS29330	COG1176	ABC-type spermidine putrescine transport system, permease component I
IGS69_RS29335	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IGS69_RS29340	COG3842	ATPase activity
IGS69_RS29355	COG3284	Transcriptional regulator
IGS69_RS29365	COG3485	protocatechuate 3,4-dioxygenase
IGS69_RS29370	COG1454	alcohol dehydrogenase
IGS69_RS29375	COG0702	epimerase
IGS69_RS29380	COG2353	YceI-like domain
IGS69_RS29390	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IGS69_RS29400	COG2182	Extracellular solute-binding protein
IGS69_RS29405	COG1175	transmembrane transport
IGS69_RS29410	COG0395	ABC-type sugar transport system, permease component
IGS69_RS29415	COG2723	6-phospho-beta-galactosidase activity
IGS69_RS29475	COG0297	glycogen (starch) synthase activity
IGS69_RS29490	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IGS69_RS29510	COG0477	Major facilitator Superfamily
IGS69_RS29520	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IGS69_RS29535	COG0406	alpha-ribazole phosphatase activity
IGS69_RS29540	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IGS69_RS29545	COG0166	Belongs to the GPI family
IGS69_RS29560	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IGS69_RS29585	COG1028	Short-chain dehydrogenase reductase Sdr
IGS69_RS29605	COG0477	Major facilitator Superfamily
IGS69_RS29615	COG1028	Short-chain dehydrogenase reductase Sdr
IGS69_RS29650	COG1486	melibiose metabolic process
IGS69_RS29670	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IGS69_RS29700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGS69_RS29700	COG2022	thiamine diphosphate biosynthetic process
IGS69_RS29715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IGS69_RS29720	COG3938	Belongs to the proline racemase family
IGS69_RS29745	COG0395	ABC-type sugar transport system, permease component
IGS69_RS29750	COG0366	Alpha amylase catalytic
IGS69_RS29775	COG1388	LysM domain
IGS69_RS29775	COG3584	3D domain protein
IGS69_RS29785	COG0477	Major facilitator Superfamily
IGS69_RS29790	COG3511	phospholipase C
IGS69_RS29820	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IGS69_RS29825	COG0477	Major facilitator Superfamily
IGS69_RS29835	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IGS69_RS29840	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IGS69_RS29845	COG3485	protocatechuate 3,4-dioxygenase
IGS69_RS29850	COG3485	protocatechuate 3,4-dioxygenase
IGS69_RS29855	COG0183	Belongs to the thiolase family
IGS69_RS29870	COG1846	Transcriptional regulator
IGS69_RS29885	COG1793	dna ligase
IGS69_RS29955	COG1834	amidinotransferase
IGS69_RS29960	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IGS69_RS29965	COG0488	(ABC) transporter
IGS69_RS29995	COG1515	deoxyribonuclease V activity
IGS69_RS30010	COG3268	Saccharopine dehydrogenase
IGS69_RS30020	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IGS69_RS30025	COG0183	Belongs to the thiolase family
IGS69_RS30030	COG1250	3-hydroxyacyl-CoA dehydrogenase
IGS69_RS30030	COG1024	Enoyl-CoA hydratase
IGS69_RS30035	COG0789	Transcriptional regulator
IGS69_RS30040	COG1113	amino acid transport
IGS69_RS30055	COG2936	dipeptidyl-peptidase activity
IGS69_RS30065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IGS69_RS30080	COG0488	(ABC) transporter
IGS69_RS30090	COG2183	response to ionizing radiation
IGS69_RS30100	COG1024	Enoyl-CoA hydratase
IGS69_RS30110	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IGS69_RS30155	COG1134	teichoic acid transport
IGS69_RS30160	COG1562	ergosterol biosynthetic process
IGS69_RS30170	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IGS69_RS30180	COG1657	PFAM Prenyltransferase squalene oxidase
IGS69_RS30195	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IGS69_RS30200	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IGS69_RS30220	COG2365	Tyrosine phosphatase family
IGS69_RS30230	COG2755	lipolytic protein G-D-S-L family
IGS69_RS30275	COG1063	alcohol dehydrogenase
IGS69_RS30280	COG0156	8-amino-7-oxononanoate synthase activity
IGS69_RS30285	COG0583	DNA-binding transcription factor activity
IGS69_RS30305	COG3958	Transketolase
IGS69_RS30355	COG0006	proline dipeptidase activity
IGS69_RS30360	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IGS69_RS30365	COG0022	dehydrogenase e1 component
IGS69_RS30370	COG0402	S-adenosylhomocysteine deaminase activity
IGS69_RS30400	COG0183	Belongs to the thiolase family
IGS69_RS30410	COG0647	UMP catabolic process
IGS69_RS30500	COG3387	PFAM Glycoside hydrolase 15-related
IGS69_RS30515	COG2188	Transcriptional regulator
IGS69_RS30525	COG3962	Belongs to the TPP enzyme family
IGS69_RS30530	COG3718	enzyme involved in inositol metabolism
IGS69_RS30540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IGS69_RS30560	COG1312	Catalyzes the dehydration of D-mannonate
IGS69_RS30565	COG0673	inositol 2-dehydrogenase activity
IGS69_RS30570	COG0673	inositol 2-dehydrogenase activity
IGS69_RS30575	COG1028	Short-chain dehydrogenase reductase Sdr
IGS69_RS30585	COG1609	Transcriptional regulator
IGS69_RS30590	COG3548	integral membrane protein
IGS69_RS30595	COG0673	inositol 2-dehydrogenase activity
IGS69_RS30600	COG1609	Transcriptional regulator
IGS69_RS30660	COG2838	Isocitrate dehydrogenase
IGS69_RS30670	COG0668	transmembrane transport
IGS69_RS30675	COG1024	Enoyl-CoA hydratase
IGS69_RS30685	COG1132	(ABC) transporter
IGS69_RS30695	COG3290	protein histidine kinase activity
IGS69_RS30700	COG4565	transcriptional regulatory protein
IGS69_RS30710	COG3486	L-lysine 6-monooxygenase (NADPH) activity
IGS69_RS30715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IGS69_RS30720	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IGS69_RS30725	COG1120	ATPase activity
IGS69_RS30730	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
IGS69_RS30735	COG1132	(ABC) transporter
IGS69_RS30745	COG1132	(ABC) transporter
IGS69_RS30750	COG2382	esterase
IGS69_RS30770	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IGS69_RS30780	COG0702	epimerase
IGS69_RS30795	COG1012	belongs to the aldehyde dehydrogenase family
IGS69_RS30805	COG0656	L-ascorbic acid biosynthetic process
IGS69_RS30810	COG0431	NADPH-dependent FMN reductase
IGS69_RS30830	COG0047	phosphoribosylformylglycinamidine synthase activity
IGS69_RS30845	COG2301	Belongs to the HpcH HpaI aldolase family
IGS69_RS30850	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
IGS69_RS30855	COG0477	Major facilitator Superfamily
IGS69_RS30895	COG1063	alcohol dehydrogenase
IGS69_RS30910	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IGS69_RS30920	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IGS69_RS30940	COG0297	glycogen (starch) synthase activity
IGS69_RS30945	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IGS69_RS30950	COG3250	beta-galactosidase activity
IGS69_RS30995	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IGS69_RS31015	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IGS69_RS31020	COG2770	Histidine kinase
IGS69_RS31020	COG2208	phosphoserine phosphatase activity
IGS69_RS31050	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IGS69_RS31050	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IGS69_RS31055	COG0726	polysaccharide deacetylase
IGS69_RS31100	COG0583	DNA-binding transcription factor activity
IGS69_RS31110	COG1053	succinate dehydrogenase
IGS69_RS31115	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IGS69_RS31190	COG1028	Short-chain dehydrogenase reductase Sdr
IGS69_RS31225	COG1609	Transcriptional regulator
IGS69_RS31235	COG2814	Major facilitator Superfamily
IGS69_RS31245	COG0475	glutathione-regulated potassium exporter activity
IGS69_RS31250	COG2197	response regulator
IGS69_RS31275	COG0326	Molecular chaperone. Has ATPase activity
IGS69_RS31315	COG3594	Acyltransferase
IGS69_RS31350	COG0673	inositol 2-dehydrogenase activity
IGS69_RS31370	COG1175	transmembrane transport
IGS69_RS31375	COG0395	ABC-type sugar transport system, permease component
IGS69_RS31400	COG2608	mercury ion transmembrane transporter activity
IGS69_RS31410	COG3387	PFAM Glycoside hydrolase 15-related
IGS69_RS31415	COG1349	DNA-binding transcription factor activity
IGS69_RS31420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IGS69_RS31425	COG0191	fructose-bisphosphate aldolase activity
IGS69_RS31430	COG2813	Specifically methylates the guanine in position
IGS69_RS31440	COG1940	carbohydrate kinase activity
IGS69_RS31445	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IGS69_RS31490	COG1349	DNA-binding transcription factor activity
IGS69_RS31525	COG1215	transferase activity, transferring glycosyl groups
IGS69_RS31555	COG1028	Short-chain dehydrogenase reductase Sdr
IGS69_RS31585	COG3835	regulator
IGS69_RS31590	COG3290	protein histidine kinase activity
IGS69_RS31595	COG2208	phosphoserine phosphatase activity
IGS69_RS31595	COG2770	Histidine kinase
IGS69_RS31625	COG3850	Histidine kinase
IGS69_RS31625	COG2205	protein histidine kinase activity
IGS69_RS31625	COG3437	response regulator, receiver
IGS69_RS31625	COG4999	Histidine kinase
IGS69_RS31640	COG1595	DNA-templated transcription, initiation
IGS69_RS31645	COG0281	malic enzyme
IGS69_RS31670	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
IGS69_RS31695	COG0375	protein maturation
IGS69_RS31710	COG0298	carbon dioxide binding
IGS69_RS31715	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IGS69_RS31725	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IGS69_RS31730	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IGS69_RS31730	COG1024	Enoyl-CoA hydratase
IGS69_RS31755	COG3396	Phenylacetate-CoA oxygenase
IGS69_RS31760	COG3460	Phenylacetate-CoA oxygenase
IGS69_RS31765	COG3396	Phenylacetate-CoA oxygenase
IGS69_RS31770	COG2151	metal-sulfur cluster biosynthetic enzyme
IGS69_RS31775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IGS69_RS31800	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IGS69_RS31835	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IGS69_RS31840	COG1993	acr, cog1993
IGS69_RS31845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IGS69_RS31850	COG1968	undecaprenyl-diphosphatase activity
IGS69_RS31855	COG2186	Transcriptional regulator
IGS69_RS31860	COG1113	amino acid transport
IGS69_RS31875	COG2066	Belongs to the glutaminase family
IGS69_RS31885	COG1686	Belongs to the peptidase S11 family
IGS69_RS31890	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IGS69_RS31905	COG1695	Transcriptional regulator
IGS69_RS31925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IGS69_RS31930	COG3458	cephalosporin-C deacetylase activity
IGS69_RS31945	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IGS69_RS31955	COG2890	protein-(glutamine-N5) methyltransferase activity
IGS69_RS31975	COG0446	pyridine nucleotide-disulphide oxidoreductase
IGS69_RS31975	COG1902	pentaerythritol trinitrate reductase activity
IGS69_RS32000	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
IGS69_RS32005	COG1461	Dihydroxyacetone kinase
IGS69_RS32010	COG2376	Dihydroxyacetone kinase
IGS69_RS32015	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IGS69_RS32085	COG1960	acyl-CoA dehydrogenase activity
IGS69_RS32095	COG0443	Heat shock 70 kDa protein
IGS69_RS32100	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IGS69_RS32115	COG0542	response to heat
IGS69_RS32130	COG3634	alkyl hydroperoxide reductase activity
IGS69_RS32135	COG0071	Belongs to the small heat shock protein (HSP20) family
IGS69_RS32140	COG2814	Major facilitator Superfamily
IGS69_RS32180	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IGS69_RS32200	COG0517	IMP dehydrogenase activity
IGS69_RS32200	COG0516	GMP reductase activity
IGS69_RS32215	COG1063	alcohol dehydrogenase
IGS69_RS32250	COG0515	serine threonine protein kinase
IGS69_RS32265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IGS69_RS32270	COG2070	2-Nitropropane dioxygenase
IGS69_RS32280	COG2366	antibiotic biosynthetic process
IGS69_RS32285	COG0318	PFAM AMP-dependent synthetase and ligase
IGS69_RS32300	COG1024	Enoyl-CoA hydratase
IGS69_RS32400	COG0431	NADPH-dependent FMN reductase
IGS69_RS32430	COG0667	Aldo Keto reductase
IGS69_RS32440	COG0346	lactoylglutathione lyase activity
IGS69_RS32445	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IGS69_RS32465	COG0667	Aldo Keto reductase
IGS69_RS32480	COG1716	ATPase activity
IGS69_RS32480	COG1131	(ABC) transporter
IGS69_RS32480	COG0842	Transport permease protein
IGS69_RS32525	COG1191	sigma factor activity
IGS69_RS32530	COG1396	sequence-specific DNA binding
IGS69_RS32535	COG0740	serine-type endopeptidase activity
IGS69_RS32540	COG0740	serine-type endopeptidase activity
IGS69_RS32545	COG0596	Alpha beta hydrolase
IGS69_RS32570	COG0328	RNA-DNA hybrid ribonuclease activity
IGS69_RS32605	COG0667	Aldo Keto reductase
IGS69_RS32615	COG3647	Membrane
IGS69_RS32640	COG0515	serine threonine protein kinase
IGS69_RS32645	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IGS69_RS32670	COG1672	PFAM Archaeal ATPase
IGS69_RS32670	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IGS69_RS32680	COG3852	Histidine kinase
IGS69_RS32705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IGS69_RS32765	COG1982	Orn Lys Arg decarboxylase major
IGS69_RS32825	COG2172	sigma factor antagonist activity
IGS69_RS32830	COG1366	Belongs to the anti-sigma-factor antagonist family
IGS69_RS32835	COG1366	Belongs to the anti-sigma-factor antagonist family
IGS69_RS32865	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IGS69_RS32870	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IGS69_RS32885	COG0366	Alpha amylase catalytic
IGS69_RS32925	COG0181	hydroxymethylbilane synthase activity
IGS69_RS32945	COG2223	nitrite transmembrane transporter activity
IGS69_RS32950	COG2207	Transcriptional regulator
IGS69_RS32975	COG0656	L-ascorbic acid biosynthetic process
IGS69_RS32980	COG1609	Transcriptional regulator
IGS69_RS32990	COG0395	ABC-type sugar transport system, permease component
IGS69_RS32995	COG1175	transmembrane transport
IGS69_RS33005	COG1621	beta-fructofuranosidase activity
IGS69_RS33030	COG0009	L-threonylcarbamoyladenylate synthase
IGS69_RS33080	COG0753	catalase activity
IGS69_RS33110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IGS69_RS33130	COG1473	amidohydrolase
IGS69_RS33135	COG1982	Orn Lys Arg decarboxylase major
IGS69_RS33160	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IGS69_RS33170	COG3540	Alkaline phosphatase
IGS69_RS33225	COG1295	ribonuclease BN
IGS69_RS33230	COG0456	acetyltransferase
IGS69_RS33245	COG2409	Drug exporters of the RND superfamily
IGS69_RS33305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS69_RS33350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IGS69_RS33365	COG2124	cytochrome p450
IGS69_RS33380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IGS69_RS33390	COG2197	response regulator
IGS69_RS33395	COG3851	Histidine kinase
IGS69_RS33415	COG1280	lysine exporter protein (LysE YggA)
IGS69_RS33420	COG5640	endopeptidase activity
IGS69_RS33425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IGS69_RS33430	COG1937	Protein conserved in bacteria
IGS69_RS33445	COG2508	Transcriptional regulator
IGS69_RS33455	COG0411	ABC transporter
IGS69_RS33485	COG3619	membrane
IGS69_RS33510	COG3033	Beta-eliminating lyase
IGS69_RS33540	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IGS69_RS33565	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IGS69_RS33570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IGS69_RS33575	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IGS69_RS33580	COG0438	transferase activity, transferring glycosyl groups
IGS69_RS33595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IGS69_RS33600	COG3848	Pyruvate phosphate dikinase
IGS69_RS33600	COG0574	Belongs to the PEP-utilizing enzyme family
IGS69_RS33645	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IGS69_RS33690	COG1012	belongs to the aldehyde dehydrogenase family
IGS69_RS33705	COG4978	Transcriptional regulator
IGS69_RS33705	COG0789	Transcriptional regulator
IGS69_RS33790	COG2267	carboxylic ester hydrolase activity
IGS69_RS33815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IGS69_RS33820	COG2146	nitrite reductase [NAD(P)H] activity
IGS69_RS33825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IGS69_RS33830	COG4638	Rieske (2fe-2S)
IGS69_RS33840	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IGS69_RS33845	COG1012	belongs to the aldehyde dehydrogenase family
IGS69_RS33850	COG0517	IMP dehydrogenase activity
IGS69_RS33850	COG4175	Glycine betaine
IGS69_RS33855	COG4176	ABC-type proline glycine betaine transport system permease component
IGS69_RS33885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IGS69_RS33915	COG4638	Rieske (2fe-2S)
IGS69_RS33935	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IGS69_RS33945	COG0297	glycogen (starch) synthase activity
IGS69_RS33960	COG0438	transferase activity, transferring glycosyl groups
IGS69_RS33990	COG2353	YceI-like domain
IGS69_RS34015	COG1295	ribonuclease BN
IGS69_RS34015	COG1959	2 iron, 2 sulfur cluster binding
IGS69_RS34030	COG1595	DNA-templated transcription, initiation
IGS69_RS34035	COG0702	epimerase
IGS69_RS34040	COG1278	Cold shock
IGS69_RS34045	COG2814	Major facilitator Superfamily
IGS69_RS34060	COG0583	DNA-binding transcription factor activity
IGS69_RS34075	COG3629	intracellular signal transduction
IGS69_RS34075	COG3903	Transcriptional regulator
IGS69_RS34105	COG3903	Transcriptional regulator
IGS69_RS34105	COG3629	intracellular signal transduction
IGS69_RS34110	COG1132	(ABC) transporter
IGS69_RS34180	COG0515	serine threonine protein kinase
IGS69_RS34180	COG2815	serine threonine protein kinase