locus-tag	class	description
AQF52_RS00160	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
AQF52_RS00160	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AQF52_RS00295	COG4249	Peptidase C14 caspase catalytic subunit p20
AQF52_RS00295	COG2319	Wd-40 repeat
AQF52_RS00475	COG2226	methyltransferase
AQF52_RS00515	COG0477	Major facilitator Superfamily
AQF52_RS00610	COG2197	response regulator
AQF52_RS00630	COG4585	Histidine kinase
AQF52_RS00635	COG2197	response regulator
AQF52_RS00665	COG0604	alcohol dehydrogenase
AQF52_RS00715	COG3547	Transposase (IS116 IS110 IS902 family)
AQF52_RS00825	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AQF52_RS00885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AQF52_RS00935	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AQF52_RS00950	COG2197	response regulator
AQF52_RS01015	COG0640	Transcriptional regulator
AQF52_RS01050	COG0583	DNA-binding transcription factor activity
AQF52_RS01055	COG4221	oxidoreductase activity
AQF52_RS01075	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS01075	COG3321	synthase
AQF52_RS01075	COG0604	alcohol dehydrogenase
AQF52_RS01085	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AQF52_RS01120	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AQF52_RS01185	COG4221	oxidoreductase activity
AQF52_RS01210	COG3842	ATPase activity
AQF52_RS01215	COG1178	ABC-type Fe3 transport system permease component
AQF52_RS01220	COG1840	ABC-type Fe3 transport system, periplasmic component
AQF52_RS01225	COG0318	PFAM AMP-dependent synthetase and ligase
AQF52_RS01265	COG0667	Aldo Keto reductase
AQF52_RS01360	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS01385	COG1136	(ABC) transporter
AQF52_RS01385	COG0577	efflux transmembrane transporter activity
AQF52_RS01400	COG0318	PFAM AMP-dependent synthetase and ligase
AQF52_RS01405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AQF52_RS01460	COG1802	Transcriptional regulator
AQF52_RS01465	COG0395	ABC-type sugar transport system, permease component
AQF52_RS01470	COG1175	transmembrane transport
AQF52_RS01475	COG1653	transport
AQF52_RS01485	COG4948	Mandelate Racemase Muconate Lactonizing
AQF52_RS01490	COG0477	Major facilitator Superfamily
AQF52_RS01505	COG0800	Aldolase
AQF52_RS01510	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS01515	COG1802	Transcriptional regulator
AQF52_RS01540	COG1597	lipid kinase activity
AQF52_RS01545	COG0277	FAD linked oxidase domain protein
AQF52_RS01560	COG1011	Hydrolase
AQF52_RS01630	COG1414	Transcriptional regulator
AQF52_RS01690	COG0477	Major facilitator Superfamily
AQF52_RS01715	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
AQF52_RS01765	COG0667	Aldo Keto reductase
AQF52_RS01770	COG2197	response regulator
AQF52_RS01775	COG4585	Histidine kinase
AQF52_RS01780	COG2409	Drug exporters of the RND superfamily
AQF52_RS01825	COG3293	Transposase
AQF52_RS01830	COG2318	DinB family
AQF52_RS01880	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AQF52_RS01885	COG0596	Alpha beta hydrolase
AQF52_RS01910	COG1309	transcriptional regulator
AQF52_RS01935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AQF52_RS01940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AQF52_RS01945	COG0456	acetyltransferase
AQF52_RS01960	COG2197	response regulator
AQF52_RS01965	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AQF52_RS01970	COG0697	spore germination
AQF52_RS01980	COG0137	argininosuccinate synthase activity
AQF52_RS01985	COG1834	amidinotransferase
AQF52_RS02015	COG0154	amidase activity
AQF52_RS02020	COG0284	orotidine-5'-phosphate decarboxylase activity
AQF52_RS02130	COG0640	Transcriptional regulator
AQF52_RS02140	COG1247	-acetyltransferase
AQF52_RS02145	COG0640	Transcriptional regulator
AQF52_RS02150	COG0640	Transcriptional regulator
AQF52_RS02160	COG0456	acetyltransferase
AQF52_RS02160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AQF52_RS02175	COG2072	flavoprotein involved in K transport
AQF52_RS02180	COG0798	PFAM Bile acid sodium symporter
AQF52_RS02190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AQF52_RS02195	COG0492	ferredoxin-NADP+ reductase activity
AQF52_RS02200	COG0640	Transcriptional regulator
AQF52_RS02205	COG0640	Transcriptional regulator
AQF52_RS02210	COG2226	methyltransferase
AQF52_RS02235	COG0573	inorganic phosphate transmembrane transporter activity
AQF52_RS02240	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AQF52_RS02250	COG0366	Alpha amylase catalytic
AQF52_RS02265	COG0395	ABC-type sugar transport system, permease component
AQF52_RS02270	COG1175	transmembrane transport
AQF52_RS02275	COG1653	transport
AQF52_RS02280	COG1940	carbohydrate kinase activity
AQF52_RS02280	COG1846	Transcriptional regulator
AQF52_RS02325	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AQF52_RS02345	COG1609	Transcriptional regulator
AQF52_RS02385	COG2508	Transcriptional regulator
AQF52_RS02390	COG3585	molybdate ion transport
AQF52_RS02400	COG0259	pyridoxamine-phosphate oxidase activity
AQF52_RS02410	COG2226	methyltransferase
AQF52_RS02415	COG3291	Pkd domain containing protein
AQF52_RS02435	COG1819	glycosyl
AQF52_RS02460	COG3263	regulation of cellular component size
AQF52_RS02490	COG2267	carboxylic ester hydrolase activity
AQF52_RS02535	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AQF52_RS02545	COG2267	carboxylic ester hydrolase activity
AQF52_RS02580	COG2188	Transcriptional regulator
AQF52_RS02585	COG2188	Transcriptional regulator
AQF52_RS02590	COG2182	Extracellular solute-binding protein
AQF52_RS02595	COG1175	transmembrane transport
AQF52_RS02600	COG0395	ABC-type sugar transport system, permease component
AQF52_RS02605	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AQF52_RS02620	COG1309	transcriptional regulator
AQF52_RS02625	COG0318	PFAM AMP-dependent synthetase and ligase
AQF52_RS02670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AQF52_RS02680	COG1802	Transcriptional regulator
AQF52_RS02715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AQF52_RS02720	COG0601	transmembrane transport
AQF52_RS02730	COG4608	Belongs to the ABC transporter superfamily
AQF52_RS02795	COG0583	DNA-binding transcription factor activity
AQF52_RS02805	COG3896	Chloramphenicol phosphotransferase-like protein
AQF52_RS02830	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS02840	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AQF52_RS02840	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AQF52_RS02865	COG1024	Enoyl-CoA hydratase
AQF52_RS02875	COG0328	RNA-DNA hybrid ribonuclease activity
AQF52_RS02945	COG0252	asparaginase activity
AQF52_RS02955	COG2356	endonuclease I
AQF52_RS02960	COG0456	acetyltransferase
AQF52_RS02970	COG1917	Cupin 2, conserved barrel domain protein
AQF52_RS02975	COG5285	phytanoyl-CoA dioxygenase
AQF52_RS02980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AQF52_RS02985	COG0765	amino acid transport
AQF52_RS02990	COG0765	amino acid transport
AQF52_RS02995	COG1126	abc transporter atp-binding protein
AQF52_RS03000	COG1191	sigma factor activity
AQF52_RS03015	COG3693	PFAM glycoside hydrolase, family 10
AQF52_RS03030	COG0673	inositol 2-dehydrogenase activity
AQF52_RS03045	COG0395	ABC-type sugar transport system, permease component
AQF52_RS03050	COG1175	transmembrane transport
AQF52_RS03065	COG1472	Belongs to the glycosyl hydrolase 3 family
AQF52_RS03070	COG3507	Belongs to the glycosyl hydrolase 43 family
AQF52_RS03085	COG2160	L-arabinose isomerase activity
AQF52_RS03095	COG1609	Transcriptional regulator
AQF52_RS03110	COG4214	carbohydrate transport
AQF52_RS03120	COG1172	Belongs to the binding-protein-dependent transport system permease family
AQF52_RS03125	COG1172	Belongs to the binding-protein-dependent transport system permease family
AQF52_RS03135	COG1879	ABC-type sugar transport system periplasmic component
AQF52_RS03140	COG1063	alcohol dehydrogenase
AQF52_RS03175	COG2124	cytochrome p450
AQF52_RS03180	COG2124	cytochrome p450
AQF52_RS03185	COG0142	geranyltranstransferase activity
AQF52_RS03260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AQF52_RS03265	COG2867	negative regulation of translational initiation
AQF52_RS03305	COG2304	oxidoreductase activity
AQF52_RS03320	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AQF52_RS03325	COG2814	Major facilitator Superfamily
AQF52_RS03330	COG0789	Transcriptional regulator
AQF52_RS03340	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AQF52_RS03340	COG2010	Cytochrome c
AQF52_RS03345	COG4106	trans-aconitate 2-methyltransferase activity
AQF52_RS03350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AQF52_RS03350	COG0519	Catalyzes the synthesis of GMP from XMP
AQF52_RS03370	COG2272	Belongs to the type-B carboxylesterase lipase family
AQF52_RS03410	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AQF52_RS03420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AQF52_RS03430	COG0747	negative chemotaxis
AQF52_RS03455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AQF52_RS03480	COG0640	Transcriptional regulator
AQF52_RS03485	COG2814	Major facilitator Superfamily
AQF52_RS03495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AQF52_RS03500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AQF52_RS03520	COG2409	Drug exporters of the RND superfamily
AQF52_RS03530	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AQF52_RS03605	COG1024	Enoyl-CoA hydratase
AQF52_RS03620	COG1357	PFAM Pentapeptide repeats (8 copies)
AQF52_RS03635	COG2124	cytochrome p450
AQF52_RS03655	COG0318	PFAM AMP-dependent synthetase and ligase
AQF52_RS03660	COG2366	antibiotic biosynthetic process
AQF52_RS03665	COG0387	Pfam Sodium calcium exchanger
AQF52_RS03670	COG1846	Transcriptional regulator
AQF52_RS03690	COG2070	2-Nitropropane dioxygenase
AQF52_RS03695	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AQF52_RS03705	COG0596	Alpha beta hydrolase
AQF52_RS03710	COG0583	DNA-binding transcription factor activity
AQF52_RS03715	COG0156	8-amino-7-oxononanoate synthase activity
AQF52_RS03720	COG1063	alcohol dehydrogenase
AQF52_RS03735	COG0515	serine threonine protein kinase
AQF52_RS03765	COG0714	Associated with various cellular activities
AQF52_RS03775	COG0542	response to heat
AQF52_RS03800	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS03810	COG1132	(ABC) transporter
AQF52_RS03810	COG2375	cellular response to nickel ion
AQF52_RS03825	COG1796	DNA polymerase
AQF52_RS03825	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AQF52_RS03855	COG1131	(ABC) transporter
AQF52_RS03855	COG0842	Transport permease protein
AQF52_RS03855	COG1716	ATPase activity
AQF52_RS03885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AQF52_RS03895	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS03900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AQF52_RS03930	COG0517	IMP dehydrogenase activity
AQF52_RS03930	COG0516	GMP reductase activity
AQF52_RS03945	COG0137	argininosuccinate synthase activity
AQF52_RS03980	COG0730	response to heat
AQF52_RS03995	COG1132	(ABC) transporter
AQF52_RS04015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AQF52_RS04025	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AQF52_RS04030	COG0557	exoribonuclease II activity
AQF52_RS04055	COG0598	Magnesium transport protein CorA
AQF52_RS04060	COG1742	UPF0060 membrane protein
AQF52_RS04065	COG2957	Belongs to the agmatine deiminase family
AQF52_RS04095	COG2197	response regulator
AQF52_RS04100	COG4585	Histidine kinase
AQF52_RS04105	COG0517	IMP dehydrogenase activity
AQF52_RS04105	COG0516	GMP reductase activity
AQF52_RS04140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AQF52_RS04145	COG1063	alcohol dehydrogenase
AQF52_RS04155	COG0516	GMP reductase activity
AQF52_RS04155	COG0517	IMP dehydrogenase activity
AQF52_RS04165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AQF52_RS04180	COG0071	Belongs to the small heat shock protein (HSP20) family
AQF52_RS04195	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AQF52_RS04195	COG0517	IMP dehydrogenase activity
AQF52_RS04205	COG1136	(ABC) transporter
AQF52_RS04230	COG0583	DNA-binding transcription factor activity
AQF52_RS04270	COG1136	(ABC) transporter
AQF52_RS04290	COG2376	Dihydroxyacetone kinase
AQF52_RS04295	COG1461	Dihydroxyacetone kinase
AQF52_RS04305	COG0640	Transcriptional regulator
AQF52_RS04310	COG0346	lactoylglutathione lyase activity
AQF52_RS04320	COG0310	cobalt ion transport
AQF52_RS04325	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
AQF52_RS04335	COG1122	ATPase activity
AQF52_RS04340	COG0446	pyridine nucleotide-disulphide oxidoreductase
AQF52_RS04340	COG1902	pentaerythritol trinitrate reductase activity
AQF52_RS04355	COG0640	Transcriptional regulator
AQF52_RS04375	COG3401	FG-GAP repeat protein
AQF52_RS04415	COG0446	pyridine nucleotide-disulphide oxidoreductase
AQF52_RS04415	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AQF52_RS04430	COG2124	cytochrome p450
AQF52_RS04440	COG1686	Belongs to the peptidase S11 family
AQF52_RS04445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AQF52_RS04480	COG2340	Cysteine-rich secretory protein family
AQF52_RS04495	COG2838	Isocitrate dehydrogenase
AQF52_RS04505	COG3387	PFAM Glycoside hydrolase 15-related
AQF52_RS04515	COG0297	glycogen (starch) synthase activity
AQF52_RS04575	COG0138	bifunctional purine biosynthesis protein purh
AQF52_RS04590	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AQF52_RS04605	COG2837	iron assimilation
AQF52_RS04620	COG0303	'Molybdopterin
AQF52_RS04635	COG1024	Enoyl-CoA hydratase
AQF52_RS04640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AQF52_RS04645	COG1250	3-hydroxyacyl-CoA dehydrogenase
AQF52_RS04665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AQF52_RS04675	COG1120	ATPase activity
AQF52_RS04680	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AQF52_RS04685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AQF52_RS04695	COG1132	(ABC) transporter
AQF52_RS04715	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AQF52_RS04720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AQF52_RS04720	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AQF52_RS04725	COG1834	amidinotransferase
AQF52_RS04760	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AQF52_RS04800	COG2409	Drug exporters of the RND superfamily
AQF52_RS04835	COG2723	6-phospho-beta-galactosidase activity
AQF52_RS04840	COG0395	ABC-type sugar transport system, permease component
AQF52_RS04845	COG1175	transmembrane transport
AQF52_RS04850	COG2182	Extracellular solute-binding protein
AQF52_RS04855	COG1940	carbohydrate kinase activity
AQF52_RS04875	COG2207	Transcriptional regulator
AQF52_RS04895	COG1309	transcriptional regulator
AQF52_RS04905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AQF52_RS04915	COG0300	oxidoreductase activity
AQF52_RS04915	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS04915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AQF52_RS04915	COG0318	PFAM AMP-dependent synthetase and ligase
AQF52_RS04915	COG3321	synthase
AQF52_RS04940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AQF52_RS04945	COG1595	DNA-templated transcription, initiation
AQF52_RS04960	COG2226	methyltransferase
AQF52_RS04965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AQF52_RS04965	COG2226	methyltransferase
AQF52_RS04965	COG3433	isochorismatase activity
AQF52_RS04975	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AQF52_RS05005	COG1695	Transcriptional regulator
AQF52_RS05040	COG1846	Transcriptional regulator
AQF52_RS05050	COG2409	Drug exporters of the RND superfamily
AQF52_RS05070	COG1181	Belongs to the D-alanine--D-alanine ligase family
AQF52_RS05090	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AQF52_RS05100	COG2890	protein-(glutamine-N5) methyltransferase activity
AQF52_RS05120	COG1755	Isoprenylcysteine carboxyl methyltransferase
AQF52_RS05145	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS05165	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AQF52_RS05170	COG0463	Glycosyl transferase, family 2
AQF52_RS05190	COG0464	growth
AQF52_RS05200	COG1349	DNA-binding transcription factor activity
AQF52_RS05240	COG1136	(ABC) transporter
AQF52_RS05265	COG1940	carbohydrate kinase activity
AQF52_RS05275	COG2223	nitrite transmembrane transporter activity
AQF52_RS05295	COG2197	response regulator
AQF52_RS05300	COG4585	Histidine kinase
AQF52_RS05335	COG1660	Displays ATPase and GTPase activities
AQF52_RS05350	COG0515	serine threonine protein kinase
AQF52_RS05360	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AQF52_RS05380	COG0204	Acyl-transferase
AQF52_RS05420	COG0671	phosphoesterase, PA-phosphatase related
AQF52_RS05440	COG0640	Transcriptional regulator
AQF52_RS05445	COG1902	pentaerythritol trinitrate reductase activity
AQF52_RS05460	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AQF52_RS05475	COG2706	6-phosphogluconolactonase activity
AQF52_RS05490	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AQF52_RS05505	COG0598	Magnesium transport protein CorA
AQF52_RS05545	COG4566	intracellular signal transduction
AQF52_RS05550	COG5564	TIM-barrel signal transduction protein
AQF52_RS05560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AQF52_RS05565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AQF52_RS05585	COG2124	cytochrome p450
AQF52_RS05640	COG0577	efflux transmembrane transporter activity
AQF52_RS05640	COG1136	(ABC) transporter
AQF52_RS05645	COG4585	Histidine kinase
AQF52_RS05650	COG2197	response regulator
AQF52_RS05660	COG2311	Membrane
AQF52_RS05675	COG0006	proline dipeptidase activity
AQF52_RS05685	COG1505	serine-type exopeptidase activity
AQF52_RS05690	COG4044	May play a role in the intracellular transport of hydrophobic ligands
AQF52_RS05705	COG1120	ATPase activity
AQF52_RS05710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AQF52_RS05715	COG2072	flavoprotein involved in K transport
AQF52_RS05725	COG1132	(ABC) transporter
AQF52_RS05750	COG1132	(ABC) transporter
AQF52_RS05755	COG1132	(ABC) transporter
AQF52_RS05760	COG2910	NAD(P)H-binding
AQF52_RS05780	COG1946	Acyl-CoA thioesterase
AQF52_RS05795	COG0386	Belongs to the glutathione peroxidase family
AQF52_RS05810	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS05820	COG0242	peptide deformylase activity
AQF52_RS05830	COG3442	glutamine amidotransferase
AQF52_RS05835	COG0205	6-phosphofructokinase activity
AQF52_RS05855	COG0204	Acyl-transferase
AQF52_RS05860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AQF52_RS05870	COG0829	nickel cation binding
AQF52_RS05875	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AQF52_RS05880	COG0830	nickel cation binding
AQF52_RS05885	COG0804	urea catabolic process
AQF52_RS05890	COG0832	Belongs to the urease beta subunit family
AQF52_RS05895	COG0831	urea catabolic process
AQF52_RS05900	COG1309	transcriptional regulator
AQF52_RS05915	COG0740	serine-type endopeptidase activity
AQF52_RS05940	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AQF52_RS05945	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AQF52_RS05950	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AQF52_RS05990	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AQF52_RS05995	COG3663	DNA glycosylase
AQF52_RS06010	COG1940	carbohydrate kinase activity
AQF52_RS06015	COG2188	Transcriptional regulator
AQF52_RS06020	COG1595	DNA-templated transcription, initiation
AQF52_RS06040	COG2268	Band 7 protein
AQF52_RS06045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AQF52_RS06070	COG0626	cystathionine gamma-synthase activity
AQF52_RS06075	COG1522	sequence-specific DNA binding
AQF52_RS06085	COG1522	sequence-specific DNA binding
AQF52_RS06090	COG0419	ATPase involved in DNA repair
AQF52_RS06095	COG0420	3'-5' exonuclease activity
AQF52_RS06100	COG1739	Uncharacterized protein family UPF0029
AQF52_RS06110	COG0318	PFAM AMP-dependent synthetase and ligase
AQF52_RS06120	COG4249	Peptidase C14 caspase catalytic subunit p20
AQF52_RS06120	COG2319	Wd-40 repeat
AQF52_RS06130	COG1832	CoA-binding protein
AQF52_RS06140	COG1396	sequence-specific DNA binding
AQF52_RS06150	COG0110	maltose O-acetyltransferase activity
AQF52_RS06155	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AQF52_RS06165	COG1472	Belongs to the glycosyl hydrolase 3 family
AQF52_RS06185	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AQF52_RS06200	COG0183	Belongs to the thiolase family
AQF52_RS06210	COG1968	undecaprenyl-diphosphatase activity
AQF52_RS06230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AQF52_RS06240	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AQF52_RS06260	COG2318	DinB family
AQF52_RS06275	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AQF52_RS06305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AQF52_RS06340	COG0531	amino acid
AQF52_RS06360	COG1175	transmembrane transport
AQF52_RS06370	COG1609	Transcriptional regulator
AQF52_RS06380	COG1501	Belongs to the glycosyl hydrolase 31 family
AQF52_RS06385	COG2814	Major facilitator Superfamily
AQF52_RS06395	COG0656	L-ascorbic acid biosynthetic process
AQF52_RS06480	COG0697	spore germination
AQF52_RS06525	COG1695	Transcriptional regulator
AQF52_RS06570	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AQF52_RS06570	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AQF52_RS06580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AQF52_RS06600	COG1716	ATPase activity
AQF52_RS06620	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AQF52_RS06655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AQF52_RS06670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AQF52_RS06685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AQF52_RS06700	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AQF52_RS06710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AQF52_RS06725	COG2018	Roadblock/LC7 domain
AQF52_RS06765	COG2814	Major facilitator Superfamily
AQF52_RS06770	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AQF52_RS06775	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AQF52_RS06780	COG1984	allophanate hydrolase subunit 2
AQF52_RS06795	COG0438	transferase activity, transferring glycosyl groups
AQF52_RS06800	COG0438	transferase activity, transferring glycosyl groups
AQF52_RS06840	COG2270	Major facilitator Superfamily
AQF52_RS06850	COG3030	protein affecting phage T7 exclusion by the F plasmid
AQF52_RS06855	COG1216	Glycosyl transferase, family 2
AQF52_RS06890	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS06925	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AQF52_RS06930	COG0140	phosphoribosyl-ATP diphosphatase activity
AQF52_RS06935	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AQF52_RS06940	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AQF52_RS06940	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AQF52_RS06945	COG3201	nicotinamide mononucleotide transporter
AQF52_RS06980	COG1940	carbohydrate kinase activity
AQF52_RS06980	COG1846	Transcriptional regulator
AQF52_RS06990	COG2233	PERMEase
AQF52_RS07005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AQF52_RS07020	COG0531	amino acid
AQF52_RS07050	COG2390	Transcriptional regulator
AQF52_RS07055	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AQF52_RS07065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AQF52_RS07080	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AQF52_RS07105	COG0284	orotidine-5'-phosphate decarboxylase activity
AQF52_RS07110	COG0167	dihydroorotate dehydrogenase activity
AQF52_RS07115	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AQF52_RS07120	COG0505	Belongs to the CarA family
AQF52_RS07130	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AQF52_RS07135	COG0540	Belongs to the ATCase OTCase family
AQF52_RS07140	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AQF52_RS07150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AQF52_RS07155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AQF52_RS07160	COG0006	proline dipeptidase activity
AQF52_RS07170	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AQF52_RS07175	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AQF52_RS07180	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AQF52_RS07185	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AQF52_RS07195	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AQF52_RS07200	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AQF52_RS07205	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AQF52_RS07210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AQF52_RS07230	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AQF52_RS07245	COG0124	histidyl-tRNA synthetase
AQF52_RS07260	COG1196	nuclear chromosome segregation
AQF52_RS07265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AQF52_RS07275	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AQF52_RS07280	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AQF52_RS07290	COG2255	four-way junction helicase activity
AQF52_RS07295	COG0632	four-way junction helicase activity
AQF52_RS07300	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AQF52_RS07305	COG0217	transcriptional regulatory protein
AQF52_RS07310	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AQF52_RS07315	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AQF52_RS07330	COG0438	transferase activity, transferring glycosyl groups
AQF52_RS07335	COG1560	Kdo2-lipid A biosynthetic process
AQF52_RS07340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AQF52_RS07360	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AQF52_RS07365	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AQF52_RS07380	COG2176	DNA-directed DNA polymerase activity
AQF52_RS07380	COG5002	protein histidine kinase activity
AQF52_RS07430	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AQF52_RS07430	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AQF52_RS07435	COG0454	-acetyltransferase
AQF52_RS07435	COG0456	acetyltransferase
AQF52_RS07440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AQF52_RS07445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AQF52_RS07500	COG1648	precorrin-2 dehydrogenase activity
AQF52_RS07500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AQF52_RS07505	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AQF52_RS07520	COG1464	Belongs to the NlpA lipoprotein family
AQF52_RS07525	COG2011	ABC-type metal ion transport system permease component
AQF52_RS07555	COG0584	glycerophosphoryl diester phosphodiesterase
AQF52_RS07560	COG0204	Acyl-transferase
AQF52_RS07560	COG0318	PFAM AMP-dependent synthetase and ligase
AQF52_RS07565	COG0477	Major facilitator Superfamily
AQF52_RS07575	COG0165	Argininosuccinate lyase
AQF52_RS07590	COG1438	arginine binding
AQF52_RS07595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AQF52_RS07600	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AQF52_RS07605	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AQF52_RS07610	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AQF52_RS07620	COG0488	(ABC) transporter
AQF52_RS07630	COG2813	Specifically methylates the guanine in position
AQF52_RS07650	COG0697	spore germination
AQF52_RS07660	COG1649	PFAM Uncharacterised BCR, COG1649
AQF52_RS07670	COG1051	belongs to the nudix hydrolase family
AQF52_RS07695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AQF52_RS07695	COG0072	phenylalanine-tRNA ligase activity
AQF52_RS07700	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AQF52_RS07705	COG5002	protein histidine kinase activity
AQF52_RS07710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AQF52_RS07715	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AQF52_RS07720	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AQF52_RS07725	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AQF52_RS07765	COG1012	belongs to the aldehyde dehydrogenase family
AQF52_RS07770	COG0174	glutamine synthetase
AQF52_RS07780	COG1113	amino acid transport
AQF52_RS07785	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AQF52_RS07835	COG0517	IMP dehydrogenase activity
AQF52_RS07835	COG4175	Glycine betaine
AQF52_RS07840	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AQF52_RS07865	COG2226	methyltransferase
AQF52_RS07870	COG2124	cytochrome p450
AQF52_RS07880	COG0805	protein transport
AQF52_RS07885	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AQF52_RS07920	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AQF52_RS07930	COG1609	Transcriptional regulator
AQF52_RS07935	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AQF52_RS07940	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AQF52_RS07950	COG4122	O-methyltransferase activity
AQF52_RS07955	COG1222	aaa ATPase
AQF52_RS07975	COG0517	IMP dehydrogenase activity
AQF52_RS07975	COG1994	Peptidase M50
AQF52_RS07985	COG2197	response regulator
AQF52_RS07995	COG0747	negative chemotaxis
AQF52_RS08005	COG1410	methionine synthase
AQF52_RS08005	COG0646	methionine synthase
AQF52_RS08010	COG1414	Transcriptional regulator
AQF52_RS08015	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AQF52_RS08020	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AQF52_RS08025	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AQF52_RS08030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AQF52_RS08045	COG0215	cysteine-tRNA ligase activity
AQF52_RS08065	COG0598	Magnesium transport protein CorA
AQF52_RS08075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AQF52_RS08080	COG0667	Aldo Keto reductase
AQF52_RS08110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AQF52_RS08120	COG0564	pseudouridine synthase activity
AQF52_RS08135	COG1113	amino acid transport
AQF52_RS08140	COG2186	Transcriptional regulator
AQF52_RS08145	COG3265	gluconokinase activity
AQF52_RS08175	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AQF52_RS08180	COG2149	membrane
AQF52_RS08200	COG4948	Mandelate Racemase Muconate Lactonizing
AQF52_RS08210	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS08220	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS08225	COG3876	Protein conserved in bacteria
AQF52_RS08270	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS08280	COG0640	Transcriptional regulator
AQF52_RS08335	COG2851	Citrate transporter
AQF52_RS08340	COG0243	molybdopterin cofactor binding
AQF52_RS08345	COG1309	transcriptional regulator
AQF52_RS08375	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AQF52_RS08380	COG2188	Transcriptional regulator
AQF52_RS08410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AQF52_RS08420	COG0515	serine threonine protein kinase
AQF52_RS08425	COG2755	lipolytic protein G-D-S-L family
AQF52_RS08440	COG0726	polysaccharide deacetylase
AQF52_RS08450	COG1725	Transcriptional regulator
AQF52_RS08490	COG4565	transcriptional regulatory protein
AQF52_RS08525	COG0587	DNA-directed DNA polymerase activity
AQF52_RS08540	COG1454	alcohol dehydrogenase
AQF52_RS08540	COG1012	belongs to the aldehyde dehydrogenase family
AQF52_RS08555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AQF52_RS08560	COG1126	abc transporter atp-binding protein
AQF52_RS08575	COG0765	amino acid transport
AQF52_RS08595	COG1799	cell septum assembly
AQF52_RS08600	COG0477	Major facilitator Superfamily
AQF52_RS08605	COG0671	phosphoesterase, PA-phosphatase related
AQF52_RS08615	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AQF52_RS08625	COG0438	transferase activity, transferring glycosyl groups
AQF52_RS08655	COG3583	domain protein
AQF52_RS08670	COG1160	GTP binding
AQF52_RS08680	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AQF52_RS08715	COG1397	ADP-ribosylglycohydrolase
AQF52_RS08735	COG1187	pseudouridine synthase activity
AQF52_RS08740	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AQF52_RS08745	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AQF52_RS08760	COG0686	Belongs to the AlaDH PNT family
AQF52_RS08770	COG0494	nUDIX hydrolase
AQF52_RS08775	COG0504	CTP synthase activity
AQF52_RS08780	COG3387	PFAM Glycoside hydrolase 15-related
AQF52_RS08805	COG0297	glycogen (starch) synthase activity
AQF52_RS08815	COG0497	DNA recombination
AQF52_RS08820	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AQF52_RS08840	COG1120	ATPase activity
AQF52_RS08845	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AQF52_RS08850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AQF52_RS08855	COG0647	UMP catabolic process
AQF52_RS08895	COG2094	Belongs to the DNA glycosylase MPG family
AQF52_RS08905	COG1881	PFAM PEBP family protein
AQF52_RS08930	COG1119	ATPase activity
AQF52_RS08945	COG2197	response regulator
AQF52_RS08950	COG4585	Histidine kinase
AQF52_RS08955	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS08965	COG1131	(ABC) transporter
AQF52_RS08965	COG0842	Transport permease protein
AQF52_RS08965	COG1716	ATPase activity
AQF52_RS08970	COG0560	Phosphoserine phosphatase
AQF52_RS08970	COG3830	Belongs to the UPF0237 family
AQF52_RS08990	COG2186	Transcriptional regulator
AQF52_RS09005	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS09020	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AQF52_RS09040	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AQF52_RS09045	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AQF52_RS09060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AQF52_RS09110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AQF52_RS09125	COG3387	PFAM Glycoside hydrolase 15-related
AQF52_RS09165	COG1024	Enoyl-CoA hydratase
AQF52_RS09175	COG0488	(ABC) transporter
AQF52_RS09210	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AQF52_RS09215	COG1492	cobalamin metabolic process
AQF52_RS09230	COG1797	cobyrinic acid a,c-diamide synthase activity
AQF52_RS09280	COG1104	cysteine desulfurase activity
AQF52_RS09285	COG1902	pentaerythritol trinitrate reductase activity
AQF52_RS09320	COG2207	Transcriptional regulator
AQF52_RS09325	COG0604	alcohol dehydrogenase
AQF52_RS09325	COG3321	synthase
AQF52_RS09350	COG4585	Histidine kinase
AQF52_RS09355	COG2197	response regulator
AQF52_RS09360	COG0768	penicillin binding
AQF52_RS09380	COG3290	protein histidine kinase activity
AQF52_RS09385	COG0402	S-adenosylhomocysteine deaminase activity
AQF52_RS09405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AQF52_RS09410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AQF52_RS09470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AQF52_RS09480	COG2171	N-acyltransferase activity
AQF52_RS09485	COG1309	transcriptional regulator
AQF52_RS09495	COG3226	Transcriptional regulator
AQF52_RS09500	COG2076	Multidrug Resistance protein
AQF52_RS09510	COG2151	metal-sulfur cluster biosynthetic enzyme
AQF52_RS09515	COG0822	iron-sulfur transferase activity
AQF52_RS09520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AQF52_RS09525	COG0396	ATPase activity
AQF52_RS09535	COG0719	Fe-S assembly protein
AQF52_RS09560	COG1612	heme a metabolic process
AQF52_RS09580	COG0109	protoheme IX farnesyltransferase activity
AQF52_RS09590	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AQF52_RS09605	COG0363	glucosamine-6-phosphate deaminase activity
AQF52_RS09620	COG0166	Belongs to the GPI family
AQF52_RS09635	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AQF52_RS09640	COG0149	triose-phosphate isomerase activity
AQF52_RS09645	COG0126	phosphoglycerate kinase activity
AQF52_RS09650	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AQF52_RS09660	COG1481	regulation of sporulation
AQF52_RS09665	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AQF52_RS09670	COG1660	Displays ATPase and GTPase activities
AQF52_RS09675	COG0322	excinuclease ABC activity
AQF52_RS09680	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS09705	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AQF52_RS09720	COG0477	Major facilitator Superfamily
AQF52_RS09740	COG0556	nucleotide-excision repair
AQF52_RS09750	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AQF52_RS09780	COG2313	pseudouridylate synthase activity
AQF52_RS09810	COG1733	regulation of RNA biosynthetic process
AQF52_RS09840	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AQF52_RS09860	COG0237	dephospho-CoA kinase activity
AQF52_RS09875	COG2226	methyltransferase
AQF52_RS09910	COG2050	protein possibly involved in aromatic compounds catabolism
AQF52_RS09930	COG0411	ABC transporter
AQF52_RS09960	COG0737	Belongs to the 5'-nucleotidase family
AQF52_RS09980	COG0252	asparaginase activity
AQF52_RS09985	COG1605	Chorismate mutase
AQF52_RS09985	COG0287	Prephenate dehydrogenase
AQF52_RS10020	COG0513	Belongs to the DEAD box helicase family
AQF52_RS10025	COG1309	transcriptional regulator
AQF52_RS10040	COG0667	Aldo Keto reductase
AQF52_RS10055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AQF52_RS10065	COG0069	glutamate synthase activity
AQF52_RS10065	COG0070	glutamate synthase
AQF52_RS10065	COG0067	glutamate synthase
AQF52_RS10095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AQF52_RS10100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AQF52_RS10110	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AQF52_RS10120	COG0159	tryptophan synthase activity
AQF52_RS10125	COG0133	tryptophan synthase activity
AQF52_RS10135	COG0134	indole-3-glycerol-phosphate synthase activity
AQF52_RS10160	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AQF52_RS10180	COG0107	imidazoleglycerol-phosphate synthase activity
AQF52_RS10185	COG0251	oxidation-reduction process
AQF52_RS10190	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AQF52_RS10195	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AQF52_RS10205	COG0131	Imidazoleglycerol-phosphate dehydratase
AQF52_RS10210	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AQF52_RS10215	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AQF52_RS10235	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AQF52_RS10255	COG1432	Conserved Protein
AQF52_RS10260	COG0587	DNA-directed DNA polymerase activity
AQF52_RS10310	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AQF52_RS10320	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AQF52_RS10335	COG1799	cell septum assembly
AQF52_RS10340	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AQF52_RS10345	COG1496	oxidoreductase activity
AQF52_RS10355	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AQF52_RS10360	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AQF52_RS10370	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AQF52_RS10375	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AQF52_RS10385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AQF52_RS10400	COG0275	rRNA processing
AQF52_RS10410	COG0714	Associated with various cellular activities
AQF52_RS10430	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AQF52_RS10440	COG1132	(ABC) transporter
AQF52_RS10445	COG1511	domain protein
AQF52_RS10450	COG1309	transcriptional regulator
AQF52_RS10475	COG0352	thiamine-phosphate diphosphorylase activity
AQF52_RS10490	COG2022	thiamine diphosphate biosynthetic process
AQF52_RS10490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AQF52_RS10500	COG2022	thiamine diphosphate biosynthetic process
AQF52_RS10505	COG2815	serine threonine protein kinase
AQF52_RS10505	COG0515	serine threonine protein kinase
AQF52_RS10510	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AQF52_RS10520	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AQF52_RS10525	COG2193	ferroxidase activity
AQF52_RS10530	COG0243	molybdopterin cofactor binding
AQF52_RS10535	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AQF52_RS10550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AQF52_RS10560	COG4585	Histidine kinase
AQF52_RS10585	COG1940	carbohydrate kinase activity
AQF52_RS10595	COG0003	Pfam Anion-transporting ATPase
AQF52_RS10610	COG1022	Amp-dependent synthetase and ligase
AQF52_RS10625	COG0534	Mate efflux family protein
AQF52_RS10640	COG0791	NLP P60 protein
AQF52_RS10660	COG0705	Rhomboid family
AQF52_RS10670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AQF52_RS10675	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AQF52_RS10680	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AQF52_RS10685	COG0723	plastoquinol--plastocyanin reductase activity
AQF52_RS10690	COG2010	Cytochrome c
AQF52_RS10695	COG1845	cytochrome c oxidase, subunit III
AQF52_RS10705	COG1376	ErfK ybiS ycfS ynhG family protein
AQF52_RS10715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AQF52_RS10720	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AQF52_RS10730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AQF52_RS10750	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AQF52_RS10755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AQF52_RS10760	COG2197	response regulator
AQF52_RS10765	COG4585	Histidine kinase
AQF52_RS10785	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AQF52_RS10800	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AQF52_RS10805	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AQF52_RS10805	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AQF52_RS10850	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AQF52_RS10855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AQF52_RS10860	COG0508	dehydrogenase complex catalyzes the overall conversion of
AQF52_RS10870	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AQF52_RS10880	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS10920	COG0321	lipoyl(octanoyl) transferase activity
AQF52_RS10925	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AQF52_RS10970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AQF52_RS10975	COG0673	inositol 2-dehydrogenase activity
AQF52_RS11000	COG0745	RESPONSE REGULATOR receiver
AQF52_RS11020	COG2365	Tyrosine phosphatase family
AQF52_RS11045	COG1309	transcriptional regulator
AQF52_RS11075	COG0366	Alpha amylase catalytic
AQF52_RS11080	COG0395	ABC-type sugar transport system, permease component
AQF52_RS11085	COG1175	transmembrane transport
AQF52_RS11090	COG2182	Extracellular solute-binding protein
AQF52_RS11095	COG1609	Transcriptional regulator
AQF52_RS11105	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AQF52_RS11140	COG0174	glutamine synthetase
AQF52_RS11165	COG2267	carboxylic ester hydrolase activity
AQF52_RS11175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AQF52_RS11175	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AQF52_RS11180	COG2814	Major facilitator Superfamily
AQF52_RS11190	COG1309	transcriptional regulator
AQF52_RS11195	COG0477	Major facilitator Superfamily
AQF52_RS11200	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AQF52_RS11220	COG1994	Peptidase M50
AQF52_RS11275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AQF52_RS11280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AQF52_RS11285	COG1120	ATPase activity
AQF52_RS11295	COG2837	iron assimilation
AQF52_RS11300	COG0672	)-iron permease
AQF52_RS11315	COG1834	amidinotransferase
AQF52_RS11330	COG2814	Major facilitator Superfamily
AQF52_RS11360	COG0508	dehydrogenase complex catalyzes the overall conversion of
AQF52_RS11365	COG0022	dehydrogenase e1 component
AQF52_RS11405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AQF52_RS11410	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
AQF52_RS11425	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS11425	COG0604	alcohol dehydrogenase
AQF52_RS11425	COG3321	synthase
AQF52_RS11450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AQF52_RS11480	COG4585	Histidine kinase
AQF52_RS11495	COG2197	response regulator
AQF52_RS11520	COG0318	PFAM AMP-dependent synthetase and ligase
AQF52_RS11530	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AQF52_RS11575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AQF52_RS11580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AQF52_RS11585	COG0477	Major facilitator Superfamily
AQF52_RS11590	COG2409	Drug exporters of the RND superfamily
AQF52_RS11615	COG3022	response to hydroperoxide
AQF52_RS11620	COG0800	Aldolase
AQF52_RS11640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AQF52_RS11645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AQF52_RS11655	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS11665	COG2030	dehydratase
AQF52_RS11670	COG1131	(ABC) transporter
AQF52_RS11680	COG4585	Histidine kinase
AQF52_RS11695	COG2197	response regulator
AQF52_RS11700	COG4585	Histidine kinase
AQF52_RS11730	COG2197	response regulator
AQF52_RS11745	COG0183	Belongs to the thiolase family
AQF52_RS11750	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS11815	COG0860	N-Acetylmuramoyl-L-alanine amidase
AQF52_RS11825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AQF52_RS11850	COG1309	transcriptional regulator
AQF52_RS11895	COG3845	ABC transporter
AQF52_RS11915	COG0183	Belongs to the thiolase family
AQF52_RS11920	COG2124	cytochrome p450
AQF52_RS11930	COG4122	O-methyltransferase activity
AQF52_RS12005	COG2188	Transcriptional regulator
AQF52_RS12060	COG1358	cellular component organization or biogenesis
AQF52_RS12105	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AQF52_RS12110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AQF52_RS12120	COG0477	Major facilitator Superfamily
AQF52_RS12125	COG1309	transcriptional regulator
AQF52_RS12140	COG4585	Histidine kinase
AQF52_RS12145	COG2197	response regulator
AQF52_RS12160	COG0667	Aldo Keto reductase
AQF52_RS12165	COG0789	Transcriptional regulator
AQF52_RS12180	COG2205	protein histidine kinase activity
AQF52_RS12185	COG0745	RESPONSE REGULATOR receiver
AQF52_RS12200	COG1376	ErfK ybiS ycfS ynhG family protein
AQF52_RS12205	COG1741	Belongs to the pirin family
AQF52_RS12220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AQF52_RS12225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AQF52_RS12230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AQF52_RS12255	COG1309	transcriptional regulator
AQF52_RS12260	COG2084	Dehydrogenase
AQF52_RS12265	COG0583	DNA-binding transcription factor activity
AQF52_RS12295	COG1764	response to oxidative stress
AQF52_RS12300	COG2130	NADP-dependent
AQF52_RS12315	COG1077	Cell shape determining protein MreB Mrl
AQF52_RS12330	COG0318	PFAM AMP-dependent synthetase and ligase
AQF52_RS12355	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS12360	COG2249	NAD(P)H dehydrogenase (quinone) activity
AQF52_RS12365	COG0477	Major facilitator Superfamily
AQF52_RS12370	COG1846	Transcriptional regulator
AQF52_RS12375	COG1764	response to oxidative stress
AQF52_RS12395	COG0475	glutathione-regulated potassium exporter activity
AQF52_RS12420	COG3511	phospholipase C
AQF52_RS12460	COG3118	belongs to the thioredoxin family
AQF52_RS12465	COG0492	ferredoxin-NADP+ reductase activity
AQF52_RS12470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AQF52_RS12480	COG0798	PFAM Bile acid sodium symporter
AQF52_RS12495	COG0640	Transcriptional regulator
AQF52_RS12500	COG3634	alkyl hydroperoxide reductase activity
AQF52_RS12560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AQF52_RS12615	COG0789	Transcriptional regulator
AQF52_RS12645	COG1228	amidohydrolase
AQF52_RS12670	COG1484	DNA-dependent DNA replication
AQF52_RS12700	COG0739	heme binding
AQF52_RS12700	COG1196	nuclear chromosome segregation
AQF52_RS12700	COG0741	lytic transglycosylase activity
AQF52_RS12790	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AQF52_RS12825	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AQF52_RS12840	COG0745	RESPONSE REGULATOR receiver
AQF52_RS12845	COG2205	protein histidine kinase activity
AQF52_RS12850	COG2409	Drug exporters of the RND superfamily
AQF52_RS12865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AQF52_RS12875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AQF52_RS12880	COG0300	oxidoreductase activity
AQF52_RS12890	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AQF52_RS12905	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AQF52_RS12935	COG0789	Transcriptional regulator
AQF52_RS12945	COG0659	secondary active sulfate transmembrane transporter activity
AQF52_RS12955	COG2259	Doxx family
AQF52_RS12960	COG1695	Transcriptional regulator
AQF52_RS13090	COG0582	viral genome integration into host DNA
AQF52_RS13115	COG1070	Carbohydrate kinase
AQF52_RS13135	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AQF52_RS13140	COG0358	DNA primase activity
AQF52_RS13150	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AQF52_RS13170	COG2949	membrane
AQF52_RS13175	COG0243	molybdopterin cofactor binding
AQF52_RS13235	COG1017	nitric oxide dioxygenase activity
AQF52_RS13235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AQF52_RS13240	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AQF52_RS13245	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AQF52_RS13245	COG2146	nitrite reductase [NAD(P)H] activity
AQF52_RS13250	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AQF52_RS13250	COG2146	nitrite reductase [NAD(P)H] activity
AQF52_RS13255	COG1309	transcriptional regulator
AQF52_RS13265	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS13290	COG0574	Belongs to the PEP-utilizing enzyme family
AQF52_RS13290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AQF52_RS13300	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AQF52_RS13325	COG0477	Major facilitator Superfamily
AQF52_RS13335	COG0667	Aldo Keto reductase
AQF52_RS13355	COG0423	glycine-tRNA ligase activity
AQF52_RS13360	COG3443	Belongs to the bacterial solute-binding protein 9 family
AQF52_RS13360	COG0803	Belongs to the bacterial solute-binding protein 9 family
AQF52_RS13365	COG1121	(ABC) transporter
AQF52_RS13370	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AQF52_RS13385	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AQF52_RS13390	COG1381	Involved in DNA repair and RecF pathway recombination
AQF52_RS13460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AQF52_RS13480	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AQF52_RS13515	COG2315	Protein conserved in bacteria
AQF52_RS13525	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AQF52_RS13535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AQF52_RS13545	COG2226	methyltransferase
AQF52_RS13550	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AQF52_RS13555	COG1234	tRNA 3'-trailer cleavage
AQF52_RS13560	COG0537	adenosine 5'-monophosphoramidase activity
AQF52_RS13585	COG2070	2-Nitropropane dioxygenase
AQF52_RS13590	COG0484	heat shock protein binding
AQF52_RS13595	COG1420	regulation of RNA biosynthetic process
AQF52_RS13620	COG0481	GTPase activity
AQF52_RS13625	COG0268	Binds directly to 16S ribosomal RNA
AQF52_RS13640	COG2353	YceI-like domain
AQF52_RS13645	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AQF52_RS13670	COG1307	EDD domain protein, DegV family
AQF52_RS13680	COG0495	leucyl-tRNA aminoacylation
AQF52_RS13700	COG0477	Major facilitator Superfamily
AQF52_RS13715	COG0588	phosphoglycerate mutase activity
AQF52_RS13720	COG0799	negative regulation of ribosome biogenesis
AQF52_RS13730	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AQF52_RS13740	COG0501	Belongs to the peptidase M48B family
AQF52_RS13755	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AQF52_RS13765	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AQF52_RS13775	COG0463	Glycosyl transferase, family 2
AQF52_RS13790	COG0438	transferase activity, transferring glycosyl groups
AQF52_RS13795	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AQF52_RS13800	COG1216	Glycosyl transferase, family 2
AQF52_RS13805	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AQF52_RS13810	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AQF52_RS13815	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AQF52_RS13820	COG1530	ribonuclease E activity
AQF52_RS13840	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AQF52_RS13845	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AQF52_RS13860	COG0772	Belongs to the SEDS family
AQF52_RS13865	COG0768	penicillin binding
AQF52_RS13880	COG1077	Cell shape determining protein MreB Mrl
AQF52_RS13885	COG0105	UTP biosynthetic process
AQF52_RS13895	COG0285	dihydrofolate synthase activity
AQF52_RS13900	COG1077	Cell shape determining protein MreB Mrl
AQF52_RS13930	COG0525	valine-tRNA ligase activity
AQF52_RS13940	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AQF52_RS13945	COG0740	serine-type endopeptidase activity
AQF52_RS13950	COG0740	serine-type endopeptidase activity
AQF52_RS13955	COG0544	peptidyl-prolyl cis-trans isomerase activity
AQF52_RS13985	COG4552	Acetyltransferase involved in intracellular survival and related
AQF52_RS14000	COG1113	amino acid transport
AQF52_RS14010	COG1113	amino acid transport
AQF52_RS14015	COG1113	amino acid transport
AQF52_RS14020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AQF52_RS14025	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AQF52_RS14060	COG0346	lactoylglutathione lyase activity
AQF52_RS14090	COG4266	Belongs to the allantoicase family
AQF52_RS14105	COG0697	spore germination
AQF52_RS14110	COG1846	Transcriptional regulator
AQF52_RS14130	COG3291	Pkd domain containing protein
AQF52_RS14130	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AQF52_RS14140	COG0668	transmembrane transport
AQF52_RS14150	COG1653	transport
AQF52_RS14155	COG1175	transmembrane transport
AQF52_RS14160	COG0395	ABC-type sugar transport system, permease component
AQF52_RS14165	COG1486	melibiose metabolic process
AQF52_RS14180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AQF52_RS14210	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AQF52_RS14215	COG2346	COG2346, Truncated hemoglobins
AQF52_RS14230	COG1136	(ABC) transporter
AQF52_RS14230	COG0577	efflux transmembrane transporter activity
AQF52_RS14265	COG0629	single-stranded DNA binding
AQF52_RS14270	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AQF52_RS14285	COG2050	protein possibly involved in aromatic compounds catabolism
AQF52_RS14295	COG1522	sequence-specific DNA binding
AQF52_RS14330	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AQF52_RS14335	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AQF52_RS14395	COG3962	Belongs to the TPP enzyme family
AQF52_RS14400	COG3718	enzyme involved in inositol metabolism
AQF52_RS14420	COG2409	Drug exporters of the RND superfamily
AQF52_RS14430	COG0569	domain protein
AQF52_RS14430	COG0475	glutathione-regulated potassium exporter activity
AQF52_RS14450	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AQF52_RS14480	COG0673	inositol 2-dehydrogenase activity
AQF52_RS14485	COG1609	Transcriptional regulator
AQF52_RS14495	COG1472	Belongs to the glycosyl hydrolase 3 family
AQF52_RS14560	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AQF52_RS14605	COG1946	Acyl-CoA thioesterase
AQF52_RS14620	COG1309	transcriptional regulator
AQF52_RS14625	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AQF52_RS14640	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS14655	COG0076	glutamate decarboxylase activity
AQF52_RS14660	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AQF52_RS14695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AQF52_RS14705	COG0589	response to stress
AQF52_RS14715	COG4977	sequence-specific DNA binding
AQF52_RS14720	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AQF52_RS14745	COG1175	transmembrane transport
AQF52_RS14765	COG3469	chitinase activity
AQF52_RS14775	COG0745	RESPONSE REGULATOR receiver
AQF52_RS14800	COG0406	alpha-ribazole phosphatase activity
AQF52_RS14855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AQF52_RS14880	COG0318	PFAM AMP-dependent synthetase and ligase
AQF52_RS14885	COG3397	chitin binding
AQF52_RS14965	COG2188	Transcriptional regulator
AQF52_RS14975	COG1940	carbohydrate kinase activity
AQF52_RS14980	COG0673	inositol 2-dehydrogenase activity
AQF52_RS14985	COG4702	Belongs to the UPF0303 family
AQF52_RS14995	COG0179	Fumarylacetoacetate (FAA) hydrolase
AQF52_RS15000	COG0706	membrane insertase activity
AQF52_RS15020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AQF52_RS15025	COG3764	Sortase (surface protein transpeptidase)
AQF52_RS15075	COG1074	ATP-dependent DNA helicase activity
AQF52_RS15095	COG2733	membrane
AQF52_RS15100	COG4555	ABC transporter
AQF52_RS15115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AQF52_RS15155	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AQF52_RS15165	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AQF52_RS15170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AQF52_RS15175	COG1263	PTS System
AQF52_RS15180	COG1263	PTS System
AQF52_RS15200	COG1234	tRNA 3'-trailer cleavage
AQF52_RS15220	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AQF52_RS15225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AQF52_RS15240	COG1113	amino acid transport
AQF52_RS15250	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AQF52_RS15260	COG1335	isochorismatase
AQF52_RS15295	COG0277	FAD linked oxidase domain protein
AQF52_RS15305	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AQF52_RS15355	COG3654	unkown
AQF52_RS15455	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AQF52_RS15470	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AQF52_RS15475	COG0395	ABC-type sugar transport system, permease component
AQF52_RS15480	COG1175	transmembrane transport
AQF52_RS15495	COG1678	Uncharacterized ACR, COG1678
AQF52_RS15500	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AQF52_RS15505	COG0776	regulation of translation
AQF52_RS15515	COG3973	AAA domain
AQF52_RS15515	COG3973	AAA domain
AQF52_RS15535	COG0583	DNA-binding transcription factor activity
AQF52_RS15545	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AQF52_RS15550	COG0793	Belongs to the peptidase S41A family
AQF52_RS15560	COG2884	Cell division ATP-binding protein ftsE
AQF52_RS15575	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AQF52_RS15580	COG0515	serine threonine protein kinase
AQF52_RS15585	COG0515	serine threonine protein kinase
AQF52_RS15595	COG1653	transport
AQF52_RS15600	COG1175	transmembrane transport
AQF52_RS15605	COG0395	ABC-type sugar transport system, permease component
AQF52_RS15610	COG1309	transcriptional regulator
AQF52_RS15630	COG2902	Dehydrogenase
AQF52_RS15655	COG0653	protein targeting
AQF52_RS15665	COG3214	Protein conserved in bacteria
AQF52_RS15670	COG2197	response regulator
AQF52_RS15675	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AQF52_RS15685	COG0823	Involved in the tonB-independent uptake of proteins
AQF52_RS15690	COG5000	phosphorelay sensor kinase activity
AQF52_RS15690	COG5002	protein histidine kinase activity
AQF52_RS15695	COG0745	RESPONSE REGULATOR receiver
AQF52_RS15715	COG0714	Associated with various cellular activities
AQF52_RS15760	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AQF52_RS15770	COG1482	cell wall glycoprotein biosynthetic process
AQF52_RS15780	COG2835	tetraacyldisaccharide 4'-kinase activity
AQF52_RS15820	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AQF52_RS15825	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AQF52_RS15825	COG0778	Nitroreductase
AQF52_RS15880	COG1316	TRANSCRIPTIONal
AQF52_RS15885	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS15890	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AQF52_RS15950	COG2205	protein histidine kinase activity
AQF52_RS15955	COG0745	RESPONSE REGULATOR receiver
AQF52_RS15960	COG3104	oligopeptide transport
AQF52_RS15995	COG1191	sigma factor activity
AQF52_RS16000	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AQF52_RS16050	COG1228	amidohydrolase
AQF52_RS16065	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AQF52_RS16110	COG2755	lipolytic protein G-D-S-L family
AQF52_RS16115	COG0183	Belongs to the thiolase family
AQF52_RS16130	COG0596	Alpha beta hydrolase
AQF52_RS16150	COG1136	(ABC) transporter
AQF52_RS16155	COG1136	(ABC) transporter
AQF52_RS16155	COG0577	efflux transmembrane transporter activity
AQF52_RS16160	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AQF52_RS16165	COG1252	NADH dehydrogenase
AQF52_RS16185	COG0148	phosphopyruvate hydratase activity
AQF52_RS16200	COG2124	cytochrome p450
AQF52_RS16225	COG0463	Glycosyl transferase, family 2
AQF52_RS16275	COG2815	serine threonine protein kinase
AQF52_RS16275	COG0515	serine threonine protein kinase
AQF52_RS16340	COG0577	efflux transmembrane transporter activity
AQF52_RS16345	COG1136	(ABC) transporter
AQF52_RS16350	COG0477	Major facilitator Superfamily
AQF52_RS16415	COG4585	Histidine kinase
AQF52_RS16425	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AQF52_RS16430	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AQF52_RS16440	COG0583	DNA-binding transcription factor activity
AQF52_RS16445	COG0768	penicillin binding
AQF52_RS16450	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AQF52_RS16455	COG0193	aminoacyl-tRNA hydrolase activity
AQF52_RS16470	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AQF52_RS16480	COG1309	transcriptional regulator
AQF52_RS16495	COG4106	trans-aconitate 2-methyltransferase activity
AQF52_RS16500	COG1846	Transcriptional regulator
AQF52_RS16505	COG2197	response regulator
AQF52_RS16510	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AQF52_RS16540	COG0488	(ABC) transporter
AQF52_RS16570	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AQF52_RS16575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AQF52_RS16580	COG1388	LysM domain
AQF52_RS16585	COG0084	hydrolase, TatD family'
AQF52_RS16620	COG0442	prolyl-tRNA aminoacylation
AQF52_RS16640	COG1595	DNA-templated transcription, initiation
AQF52_RS16650	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS16660	COG1280	lysine exporter protein (LysE YggA)
AQF52_RS16665	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AQF52_RS16675	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AQF52_RS16680	COG1122	ATPase activity
AQF52_RS16690	COG0310	cobalt ion transport
AQF52_RS16700	COG2409	Drug exporters of the RND superfamily
AQF52_RS16710	COG0793	Belongs to the peptidase S41A family
AQF52_RS16710	COG4946	Tricorn protease homolog
AQF52_RS16730	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS16735	COG2267	carboxylic ester hydrolase activity
AQF52_RS16740	COG2072	flavoprotein involved in K transport
AQF52_RS16750	COG0708	Exodeoxyribonuclease III
AQF52_RS16775	COG0521	Mo-molybdopterin cofactor biosynthetic process
AQF52_RS16780	COG0315	cyclic pyranopterin monophosphate synthase activity
AQF52_RS16790	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AQF52_RS16795	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AQF52_RS16820	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AQF52_RS16830	COG1970	mechanosensitive ion channel activity
AQF52_RS16850	COG0437	4 iron, 4 sulfur cluster binding
AQF52_RS16855	COG0243	molybdopterin cofactor binding
AQF52_RS16865	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AQF52_RS16875	COG2223	nitrite transmembrane transporter activity
AQF52_RS16895	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS16900	COG3191	aminopeptidase activity
AQF52_RS16910	COG0477	Major facilitator Superfamily
AQF52_RS16930	COG3384	dioxygenase
AQF52_RS16935	COG1846	Transcriptional regulator
AQF52_RS17020	COG1131	(ABC) transporter
AQF52_RS17035	COG0584	glycerophosphoryl diester phosphodiesterase
AQF52_RS17105	COG1686	Belongs to the peptidase S11 family
AQF52_RS17145	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AQF52_RS17260	COG0318	PFAM AMP-dependent synthetase and ligase
AQF52_RS17275	COG1024	Enoyl-CoA hydratase
AQF52_RS17290	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AQF52_RS17290	COG0515	serine threonine protein kinase
AQF52_RS17300	COG1309	transcriptional regulator
AQF52_RS17325	COG0259	pyridoxamine-phosphate oxidase activity
AQF52_RS17335	COG1309	transcriptional regulator
AQF52_RS17355	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AQF52_RS17365	COG0163	prenyltransferase activity
AQF52_RS17375	COG2255	four-way junction helicase activity
AQF52_RS17425	COG0463	Glycosyl transferase, family 2
AQF52_RS17435	COG0109	protoheme IX farnesyltransferase activity
AQF52_RS17440	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AQF52_RS17450	COG0583	DNA-binding transcription factor activity
AQF52_RS17525	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AQF52_RS17530	COG1333	cytochrome c biogenesis protein
AQF52_RS17535	COG0785	Cytochrome C biogenesis protein
AQF52_RS17550	COG0406	alpha-ribazole phosphatase activity
AQF52_RS17555	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AQF52_RS17570	COG0531	amino acid
AQF52_RS17575	COG0789	Transcriptional regulator
AQF52_RS17620	COG1846	Transcriptional regulator
AQF52_RS17640	COG1690	Belongs to the RtcB family
AQF52_RS17660	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AQF52_RS17665	COG0018	arginyl-trna synthetase
AQF52_RS17680	COG0113	porphobilinogen synthase activity
AQF52_RS17685	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AQF52_RS17685	COG1648	precorrin-2 dehydrogenase activity
AQF52_RS17690	COG0181	hydroxymethylbilane synthase activity
AQF52_RS17695	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AQF52_RS17700	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AQF52_RS17745	COG0123	including yeast histone deacetylase and acetoin utilization protein
AQF52_RS17750	COG2223	nitrite transmembrane transporter activity
AQF52_RS17755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AQF52_RS17780	COG0180	Tryptophanyl-tRNA synthetase
AQF52_RS17795	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AQF52_RS17805	COG0842	Transport permease protein
AQF52_RS17805	COG1129	ABC transporter
AQF52_RS17820	COG0515	serine threonine protein kinase
AQF52_RS17820	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AQF52_RS17825	COG0129	dihydroxy-acid dehydratase activity
AQF52_RS17835	COG1082	Xylose isomerase domain protein TIM barrel
AQF52_RS17840	COG0248	Ppx GppA phosphatase
AQF52_RS17860	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AQF52_RS17870	COG0671	phosphoesterase, PA-phosphatase related
AQF52_RS17875	COG1194	a g-specific adenine glycosylase
AQF52_RS17880	COG1595	DNA-templated transcription, initiation
AQF52_RS17890	COG0745	RESPONSE REGULATOR receiver
AQF52_RS17895	COG2205	protein histidine kinase activity
AQF52_RS17910	COG0739	heme binding
AQF52_RS17935	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AQF52_RS17955	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AQF52_RS17960	COG0157	Belongs to the NadC ModD family
AQF52_RS17965	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AQF52_RS17970	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AQF52_RS17980	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AQF52_RS17995	COG2197	response regulator
AQF52_RS18010	COG0649	NAD binding
AQF52_RS18025	COG1732	Glycine betaine
AQF52_RS18030	COG1174	glycine betaine transport
AQF52_RS18050	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AQF52_RS18050	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AQF52_RS18065	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AQF52_RS18080	COG0302	gtp cyclohydrolase
AQF52_RS18095	COG0037	tRNA processing
AQF52_RS18105	COG2027	D-alanyl-D-alanine carboxypeptidase
AQF52_RS18110	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AQF52_RS18120	COG0586	Pfam SNARE associated Golgi protein
AQF52_RS18125	COG0393	Putative heavy-metal-binding
AQF52_RS18135	COG0076	glutamate decarboxylase activity
AQF52_RS18160	COG2318	DinB family
AQF52_RS18165	COG1012	belongs to the aldehyde dehydrogenase family
AQF52_RS18190	COG0254	rRNA binding
AQF52_RS18195	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AQF52_RS18200	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AQF52_RS18205	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AQF52_RS18215	COG1595	DNA-templated transcription, initiation
AQF52_RS18225	COG1289	transmembrane transporter activity
AQF52_RS18235	COG1136	(ABC) transporter
AQF52_RS18255	COG2197	response regulator
AQF52_RS18260	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AQF52_RS18260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AQF52_RS18280	COG1595	DNA-templated transcription, initiation
AQF52_RS18315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AQF52_RS18320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AQF52_RS18335	COG0736	holo-[acyl-carrier-protein] synthase activity
AQF52_RS18360	COG3903	Transcriptional regulator
AQF52_RS18360	COG3629	intracellular signal transduction
AQF52_RS18375	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AQF52_RS18390	COG2197	response regulator
AQF52_RS18400	COG0577	efflux transmembrane transporter activity
AQF52_RS18400	COG1136	(ABC) transporter
AQF52_RS18405	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AQF52_RS18410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AQF52_RS18410	COG1754	DNA topoisomerase type I activity
AQF52_RS18430	COG1131	(ABC) transporter
AQF52_RS18440	COG2890	protein-(glutamine-N5) methyltransferase activity
AQF52_RS18450	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AQF52_RS18460	COG1366	Belongs to the anti-sigma-factor antagonist family
AQF52_RS18465	COG1111	helicase
AQF52_RS18465	COG1205	dead DEAH box helicase
AQF52_RS18525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AQF52_RS18530	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AQF52_RS18540	COG2267	carboxylic ester hydrolase activity
AQF52_RS18570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AQF52_RS18590	COG0003	Pfam Anion-transporting ATPase
AQF52_RS18600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AQF52_RS18610	COG1408	metallophosphoesterase
AQF52_RS18665	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AQF52_RS18670	COG2815	serine threonine protein kinase
AQF52_RS18670	COG0515	serine threonine protein kinase
AQF52_RS18680	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AQF52_RS18760	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AQF52_RS18765	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AQF52_RS18780	COG1802	Transcriptional regulator
AQF52_RS18785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AQF52_RS18790	COG0693	protein deglycase activity
AQF52_RS18830	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AQF52_RS18855	COG0583	DNA-binding transcription factor activity
AQF52_RS18865	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AQF52_RS18885	COG2197	response regulator
AQF52_RS18890	COG4585	Histidine kinase
AQF52_RS18920	COG0477	Major facilitator Superfamily
AQF52_RS18925	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AQF52_RS18930	COG0191	fructose-bisphosphate aldolase activity
AQF52_RS18935	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AQF52_RS18950	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AQF52_RS18980	COG0542	response to heat
AQF52_RS19005	COG0789	Transcriptional regulator
AQF52_RS19010	COG0484	heat shock protein binding
AQF52_RS19015	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AQF52_RS19020	COG0443	Heat shock 70 kDa protein
AQF52_RS19030	COG2181	nitrate reductase activity
AQF52_RS19030	COG0247	lactate metabolic process
AQF52_RS19040	COG2197	response regulator
AQF52_RS19070	COG0717	Belongs to the dCTP deaminase family
AQF52_RS19105	COG1278	Cold shock
AQF52_RS19110	COG0513	Belongs to the DEAD box helicase family
AQF52_RS19165	COG0215	cysteine-tRNA ligase activity
AQF52_RS19175	COG4585	Histidine kinase
AQF52_RS19180	COG2197	response regulator
AQF52_RS19200	COG1511	domain protein
AQF52_RS19205	COG1595	DNA-templated transcription, initiation
AQF52_RS19265	COG4977	sequence-specific DNA binding
AQF52_RS19270	COG0531	amino acid
AQF52_RS19290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AQF52_RS19325	COG1957	nucleoside hydrolase
AQF52_RS19385	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AQF52_RS19390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AQF52_RS19410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AQF52_RS19415	COG0431	NADPH-dependent FMN reductase
AQF52_RS19465	COG1959	2 iron, 2 sulfur cluster binding
AQF52_RS19470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AQF52_RS19505	COG1289	transmembrane transporter activity
AQF52_RS19530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AQF52_RS19540	COG2205	protein histidine kinase activity
AQF52_RS19545	COG0745	RESPONSE REGULATOR receiver
AQF52_RS19550	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AQF52_RS19610	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AQF52_RS19630	COG0628	permease
AQF52_RS19635	COG1741	Belongs to the pirin family
AQF52_RS19645	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS19650	COG1362	aminopeptidase activity
AQF52_RS19685	COG0626	cystathionine gamma-synthase activity
AQF52_RS19690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AQF52_RS19715	COG2271	Major facilitator Superfamily
AQF52_RS19730	COG0508	dehydrogenase complex catalyzes the overall conversion of
AQF52_RS19735	COG0022	dehydrogenase e1 component
AQF52_RS19760	COG0515	serine threonine protein kinase
AQF52_RS19765	COG0515	serine threonine protein kinase
AQF52_RS19780	COG1136	(ABC) transporter
AQF52_RS19780	COG4591	ABC-type transport system involved in lipoprotein release permease component
AQF52_RS19800	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AQF52_RS19805	COG0303	'Molybdopterin
AQF52_RS19815	COG0508	dehydrogenase complex catalyzes the overall conversion of
AQF52_RS19835	COG1309	transcriptional regulator
AQF52_RS19840	COG1250	3-hydroxyacyl-CoA dehydrogenase
AQF52_RS19865	COG3396	Phenylacetate-CoA oxygenase
AQF52_RS19870	COG3460	Phenylacetate-CoA oxygenase
AQF52_RS19875	COG3396	Phenylacetate-CoA oxygenase
AQF52_RS19880	COG2151	metal-sulfur cluster biosynthetic enzyme
AQF52_RS19885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AQF52_RS19895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AQF52_RS19920	COG2197	response regulator
AQF52_RS19935	COG1716	ATPase activity
AQF52_RS19940	COG1716	ATPase activity
AQF52_RS19955	COG0768	penicillin binding
AQF52_RS19960	COG0515	serine threonine protein kinase
AQF52_RS19965	COG3764	Sortase (surface protein transpeptidase)
AQF52_RS19970	COG3764	Sortase (surface protein transpeptidase)
AQF52_RS19980	COG3764	Sortase (surface protein transpeptidase)
AQF52_RS19995	COG0705	Rhomboid family
AQF52_RS20020	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AQF52_RS20025	COG3903	Transcriptional regulator
AQF52_RS20025	COG3629	intracellular signal transduction
AQF52_RS20040	COG0515	serine threonine protein kinase
AQF52_RS20060	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AQF52_RS20065	COG0187	DNA topoisomerase II activity
AQF52_RS20070	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AQF52_RS20075	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AQF52_RS20080	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AQF52_RS20085	COG0592	DNA-directed DNA polymerase activity
AQF52_RS20095	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AQF52_RS20105	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AQF52_RS20110	COG0706	membrane insertase activity
AQF52_RS20120	COG0357	Ribosomal RNA small subunit methyltransferase G
AQF52_RS20125	COG1192	Involved in chromosome partitioning
AQF52_RS20140	COG3118	belongs to the thioredoxin family
AQF52_RS20145	COG0492	ferredoxin-NADP+ reductase activity
AQF52_RS20155	COG1595	DNA-templated transcription, initiation
AQF52_RS20160	COG2815	serine threonine protein kinase
AQF52_RS20160	COG0515	serine threonine protein kinase
AQF52_RS20175	COG0617	tRNA 3'-terminal CCA addition
AQF52_RS20195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AQF52_RS20210	COG2348	transferase activity, transferring amino-acyl groups
AQF52_RS20220	COG0360	Binds together with S18 to 16S ribosomal RNA
AQF52_RS20225	COG0629	single-stranded DNA binding
AQF52_RS20230	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AQF52_RS20235	COG0359	binds to the 23S rRNA
AQF52_RS20240	COG0534	Mate efflux family protein
AQF52_RS20245	COG0305	Participates in initiation and elongation during chromosome replication
AQF52_RS20285	COG0494	nUDIX hydrolase
AQF52_RS20295	COG0626	cystathionine gamma-synthase activity
AQF52_RS20300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AQF52_RS20305	COG1950	PFAM Membrane protein of
AQF52_RS20310	COG0662	Cupin 2, conserved barrel domain protein
AQF52_RS20335	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AQF52_RS20350	COG1609	Transcriptional regulator
AQF52_RS20355	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AQF52_RS20365	COG1271	oxidase subunit
AQF52_RS20370	COG1294	oxidase, subunit
AQF52_RS20375	COG4988	ABC transporter
AQF52_RS20385	COG0561	phosphatase activity
AQF52_RS20420	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
AQF52_RS20425	COG0789	Transcriptional regulator
AQF52_RS20440	COG1131	(ABC) transporter
AQF52_RS20460	COG2807	transmembrane transport
AQF52_RS20465	COG2186	Transcriptional regulator
AQF52_RS20485	COG0561	phosphatase activity
AQF52_RS20490	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AQF52_RS20500	COG2837	iron assimilation
AQF52_RS20515	COG1999	signal sequence binding
AQF52_RS20535	COG0006	proline dipeptidase activity
AQF52_RS20555	COG0653	protein targeting
AQF52_RS20570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AQF52_RS20580	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AQF52_RS20590	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS20600	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS20620	COG1595	DNA-templated transcription, initiation
AQF52_RS20625	COG0318	PFAM AMP-dependent synthetase and ligase
AQF52_RS20630	COG0784	Response regulator, receiver
AQF52_RS20680	COG0745	RESPONSE REGULATOR receiver
AQF52_RS20685	COG2205	protein histidine kinase activity
AQF52_RS20695	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AQF52_RS20700	COG0477	Major facilitator Superfamily
AQF52_RS20710	COG0477	Major facilitator Superfamily
AQF52_RS20725	COG1309	transcriptional regulator
AQF52_RS20740	COG1191	sigma factor activity
AQF52_RS20745	COG1191	sigma factor activity
AQF52_RS20775	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AQF52_RS20790	COG0433	COG0433 Predicted ATPase
AQF52_RS20795	COG2234	aminopeptidase activity
AQF52_RS20805	COG2267	carboxylic ester hydrolase activity
AQF52_RS20815	COG1309	transcriptional regulator
AQF52_RS20820	COG0655	NAD(P)H dehydrogenase (quinone) activity
AQF52_RS20825	COG1937	Protein conserved in bacteria
AQF52_RS20840	COG3795	YCII-related domain
AQF52_RS20845	COG2095	MarC family integral membrane protein
AQF52_RS20855	COG0667	Aldo Keto reductase
AQF52_RS20860	COG2267	carboxylic ester hydrolase activity
AQF52_RS20885	COG1136	(ABC) transporter
AQF52_RS20910	COG1309	transcriptional regulator
AQF52_RS20930	COG0151	Belongs to the GarS family
AQF52_RS20945	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AQF52_RS20955	COG2197	response regulator
AQF52_RS20960	COG3850	Histidine kinase
AQF52_RS20990	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AQF52_RS20995	COG0047	phosphoribosylformylglycinamidine synthase activity
AQF52_RS21000	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AQF52_RS21035	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AQF52_RS21070	COG1643	Atp-dependent helicase
AQF52_RS21080	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AQF52_RS21080	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AQF52_RS21085	COG0785	Cytochrome C biogenesis protein
AQF52_RS21115	COG0513	Belongs to the DEAD box helicase family
AQF52_RS21145	COG1597	lipid kinase activity
AQF52_RS21155	COG1595	DNA-templated transcription, initiation
AQF52_RS21170	COG0789	Transcriptional regulator
AQF52_RS21180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AQF52_RS21195	COG1196	nuclear chromosome segregation
AQF52_RS21195	COG0739	heme binding
AQF52_RS21195	COG0741	lytic transglycosylase activity
AQF52_RS21200	COG0667	Aldo Keto reductase
AQF52_RS21215	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AQF52_RS21220	COG0579	oxidoreductase
AQF52_RS21255	COG1252	NADH dehydrogenase
AQF52_RS21270	COG1846	Transcriptional regulator
AQF52_RS21315	COG2197	response regulator
AQF52_RS21320	COG4585	Histidine kinase
AQF52_RS21330	COG1131	(ABC) transporter
AQF52_RS21370	COG1309	transcriptional regulator
AQF52_RS21380	COG1196	nuclear chromosome segregation
AQF52_RS21380	COG0741	lytic transglycosylase activity
AQF52_RS21380	COG0739	heme binding
AQF52_RS21385	COG0671	phosphoesterase, PA-phosphatase related
AQF52_RS21400	COG1937	Protein conserved in bacteria
AQF52_RS21410	COG0306	phosphate transporter
AQF52_RS21430	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AQF52_RS21460	COG1725	Transcriptional regulator
AQF52_RS21465	COG0456	acetyltransferase
AQF52_RS21470	COG0737	Belongs to the 5'-nucleotidase family
AQF52_RS21475	COG0823	Involved in the tonB-independent uptake of proteins
AQF52_RS21485	COG0745	RESPONSE REGULATOR receiver
AQF52_RS21490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AQF52_RS21495	COG1609	Transcriptional regulator
AQF52_RS21500	COG0745	RESPONSE REGULATOR receiver
AQF52_RS21525	COG2897	thiosulfate sulfurtransferase activity
AQF52_RS21560	COG3485	protocatechuate 3,4-dioxygenase
AQF52_RS21570	COG0354	folic acid binding
AQF52_RS21575	COG1490	D-aminoacyl-tRNA deacylase activity
AQF52_RS21585	COG4552	Acetyltransferase involved in intracellular survival and related
AQF52_RS21620	COG0346	lactoylglutathione lyase activity
AQF52_RS21660	COG0438	transferase activity, transferring glycosyl groups
AQF52_RS21680	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AQF52_RS21690	COG0588	phosphoglycerate mutase activity
AQF52_RS21710	COG5002	protein histidine kinase activity
AQF52_RS21725	COG1329	Transcriptional regulator
AQF52_RS21730	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AQF52_RS21735	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AQF52_RS21740	COG0215	cysteine-tRNA ligase activity
AQF52_RS21755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AQF52_RS21765	COG3842	ATPase activity
AQF52_RS21775	COG4974	Belongs to the 'phage' integrase family
AQF52_RS21930	COG2188	Transcriptional regulator
AQF52_RS21935	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AQF52_RS21960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AQF52_RS22005	COG2197	response regulator
AQF52_RS22040	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AQF52_RS22085	COG0561	phosphatase activity
AQF52_RS22085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AQF52_RS22095	COG1733	regulation of RNA biosynthetic process
AQF52_RS22110	COG0463	Glycosyl transferase, family 2
AQF52_RS22130	COG0459	protein refolding
AQF52_RS22180	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AQF52_RS22185	COG1737	Transcriptional regulator
AQF52_RS22265	COG0626	cystathionine gamma-synthase activity
AQF52_RS22270	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AQF52_RS22280	COG4106	trans-aconitate 2-methyltransferase activity
AQF52_RS22295	COG0736	holo-[acyl-carrier-protein] synthase activity
AQF52_RS22310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AQF52_RS22315	COG0646	methionine synthase
AQF52_RS22315	COG1410	methionine synthase
AQF52_RS22360	COG1113	amino acid transport
AQF52_RS22380	COG1741	Belongs to the pirin family
AQF52_RS22390	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AQF52_RS22415	COG2318	DinB family
AQF52_RS22435	COG0367	asparagine synthase
AQF52_RS22450	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AQF52_RS22450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AQF52_RS22455	COG0438	transferase activity, transferring glycosyl groups
AQF52_RS22500	COG1937	Protein conserved in bacteria
AQF52_RS22520	COG3142	Participates in the control of copper homeostasis
AQF52_RS22525	COG2197	response regulator
AQF52_RS22530	COG4585	Histidine kinase
AQF52_RS22545	COG0346	lactoylglutathione lyase activity
AQF52_RS22550	COG3973	AAA domain
AQF52_RS22565	COG1061	Type III restriction enzyme res subunit
AQF52_RS22580	COG1120	ATPase activity
AQF52_RS22585	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AQF52_RS22590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AQF52_RS22605	COG1278	Cold shock
AQF52_RS22610	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AQF52_RS22615	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AQF52_RS22625	COG2814	Major facilitator Superfamily
AQF52_RS22675	COG2226	methyltransferase
AQF52_RS22680	COG1136	(ABC) transporter
AQF52_RS22690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AQF52_RS22700	COG2252	PERMEase
AQF52_RS22730	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AQF52_RS22735	COG0667	Aldo Keto reductase
AQF52_RS22760	COG2267	carboxylic ester hydrolase activity
AQF52_RS22785	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AQF52_RS22790	COG0277	FAD linked oxidase domain protein
AQF52_RS22800	COG3123	guanosine phosphorylase activity
AQF52_RS22805	COG2318	DinB family
AQF52_RS22820	COG0583	DNA-binding transcription factor activity
AQF52_RS22840	COG3467	pyridoxamine 5'-phosphate
AQF52_RS22865	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AQF52_RS22900	COG0318	PFAM AMP-dependent synthetase and ligase
AQF52_RS22910	COG1309	transcriptional regulator
AQF52_RS22930	COG0259	pyridoxamine-phosphate oxidase activity
AQF52_RS22940	COG4821	SIS domain
AQF52_RS22950	COG0596	Alpha beta hydrolase
AQF52_RS22950	COG2945	thiolester hydrolase activity
AQF52_RS22990	COG4152	abc transporter atp-binding protein
AQF52_RS23045	COG0318	PFAM AMP-dependent synthetase and ligase
AQF52_RS23055	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS23060	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS23075	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS23115	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AQF52_RS23125	COG1024	Enoyl-CoA hydratase
AQF52_RS23140	COG2072	flavoprotein involved in K transport
AQF52_RS23155	COG0515	serine threonine protein kinase
AQF52_RS23155	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AQF52_RS23185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AQF52_RS23240	COG1196	nuclear chromosome segregation
AQF52_RS23240	COG0741	lytic transglycosylase activity
AQF52_RS23240	COG0739	heme binding
AQF52_RS23245	COG1278	Cold shock
AQF52_RS23250	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AQF52_RS23255	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AQF52_RS23275	COG2226	methyltransferase
AQF52_RS23315	COG1136	(ABC) transporter
AQF52_RS23320	COG0577	efflux transmembrane transporter activity
AQF52_RS23320	COG1136	(ABC) transporter
AQF52_RS23335	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AQF52_RS23340	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AQF52_RS23345	COG0649	NAD binding
AQF52_RS23355	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AQF52_RS23360	COG1034	ATP synthesis coupled electron transport
AQF52_RS23365	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AQF52_RS23370	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AQF52_RS23375	COG0839	Belongs to the complex I subunit 6 family
AQF52_RS23380	COG0713	ATP synthesis coupled electron transport
AQF52_RS23385	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AQF52_RS23395	COG1007	ATP synthesis coupled electron transport
AQF52_RS23400	COG2207	Transcriptional regulator
AQF52_RS23410	COG0179	Fumarylacetoacetate (FAA) hydrolase
AQF52_RS23425	COG3104	oligopeptide transport
AQF52_RS23430	COG0142	geranyltranstransferase activity
AQF52_RS23485	COG1733	regulation of RNA biosynthetic process
AQF52_RS23500	COG0702	epimerase
AQF52_RS23505	COG1733	regulation of RNA biosynthetic process
AQF52_RS23525	COG1013	pyruvate-flavodoxin oxidoreductase activity
AQF52_RS23530	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AQF52_RS23530	COG0674	pyruvate-flavodoxin oxidoreductase activity
AQF52_RS23550	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AQF52_RS23555	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AQF52_RS23560	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AQF52_RS23565	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AQF52_RS23570	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AQF52_RS23575	COG0839	Belongs to the complex I subunit 6 family
AQF52_RS23580	COG0713	ATP synthesis coupled electron transport
AQF52_RS23595	COG1007	ATP synthesis coupled electron transport
AQF52_RS23605	COG0501	Belongs to the peptidase M48B family
AQF52_RS23610	COG3304	Inner membrane component domain
AQF52_RS23630	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AQF52_RS23635	COG1666	GTP binding
AQF52_RS23645	COG0702	epimerase
AQF52_RS23650	COG0402	S-adenosylhomocysteine deaminase activity
AQF52_RS23665	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AQF52_RS23670	COG2030	dehydratase
AQF52_RS23680	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AQF52_RS23685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AQF52_RS23695	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AQF52_RS23700	COG0436	Aminotransferase
AQF52_RS23710	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AQF52_RS23720	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AQF52_RS23725	COG0081	regulation of translation
AQF52_RS23735	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AQF52_RS23740	COG0222	ribosome binding
AQF52_RS23745	COG0085	RNA polymerase activity
AQF52_RS23750	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AQF52_RS23875	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AQF52_RS23880	COG0049	tRNA binding
AQF52_RS23885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AQF52_RS23890	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AQF52_RS23900	COG4941	Belongs to the sigma-70 factor family
AQF52_RS23905	COG0051	transcription antitermination factor activity, RNA binding
AQF52_RS23910	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AQF52_RS23915	COG0088	Forms part of the polypeptide exit tunnel
AQF52_RS23920	COG0089	rRNA binding
AQF52_RS23925	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AQF52_RS23930	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AQF52_RS23935	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AQF52_RS23940	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AQF52_RS23945	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AQF52_RS23950	COG0255	Belongs to the universal ribosomal protein uL29 family
AQF52_RS23955	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AQF52_RS23960	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AQF52_RS23965	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AQF52_RS23970	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AQF52_RS23975	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AQF52_RS23980	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AQF52_RS23985	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AQF52_RS23990	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AQF52_RS23995	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AQF52_RS24000	COG1841	ribosomal large subunit assembly
AQF52_RS24005	COG0200	Binds to the 23S rRNA
AQF52_RS24015	COG0563	adenylate kinase activity
AQF52_RS24025	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AQF52_RS24030	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AQF52_RS24035	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AQF52_RS24040	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AQF52_RS24045	COG0202	RNA polymerase activity
AQF52_RS24050	COG0203	ribosomal protein L17
AQF52_RS24055	COG0101	tRNA pseudouridine synthase activity
AQF52_RS24065	COG0488	(ABC) transporter
AQF52_RS24070	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AQF52_RS24075	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AQF52_RS24080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AQF52_RS24090	COG1072	(Pantothenic acid kinase))
AQF52_RS24100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AQF52_RS24105	COG0736	holo-[acyl-carrier-protein] synthase activity
AQF52_RS24130	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AQF52_RS24140	COG0802	atpase or kinase
AQF52_RS24165	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AQF52_RS24175	COG0726	polysaccharide deacetylase
AQF52_RS24185	COG4941	Belongs to the sigma-70 factor family
AQF52_RS24205	COG0726	polysaccharide deacetylase
AQF52_RS24220	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AQF52_RS24240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AQF52_RS24245	COG0395	ABC-type sugar transport system, permease component
AQF52_RS24250	COG1175	transmembrane transport
AQF52_RS24260	COG1609	Transcriptional regulator
AQF52_RS24270	COG4221	oxidoreductase activity
AQF52_RS24280	COG0583	DNA-binding transcription factor activity
AQF52_RS24295	COG1595	DNA-templated transcription, initiation
AQF52_RS24305	COG0516	GMP reductase activity
AQF52_RS24320	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AQF52_RS24335	COG0515	serine threonine protein kinase
AQF52_RS24340	COG1012	belongs to the aldehyde dehydrogenase family
AQF52_RS24355	COG0519	Catalyzes the synthesis of GMP from XMP
AQF52_RS24355	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AQF52_RS24385	COG2197	response regulator
AQF52_RS24415	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AQF52_RS24435	COG0714	Associated with various cellular activities
AQF52_RS24440	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AQF52_RS24445	COG3552	Protein containing von Willebrand factor type A (VWA) domain
AQF52_RS24450	COG0045	succinate-CoA ligase (ADP-forming) activity
AQF52_RS24480	COG0138	bifunctional purine biosynthesis protein purh
AQF52_RS24510	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AQF52_RS24525	COG0039	L-malate dehydrogenase activity
AQF52_RS24545	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AQF52_RS24550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AQF52_RS24565	COG0754	glutathionylspermidine amidase activity
AQF52_RS24570	COG0726	polysaccharide deacetylase
AQF52_RS24590	COG1136	(ABC) transporter
AQF52_RS24595	COG1136	(ABC) transporter
AQF52_RS24595	COG0577	efflux transmembrane transporter activity
AQF52_RS24600	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AQF52_RS24615	COG0180	Tryptophanyl-tRNA synthetase
AQF52_RS24635	COG1686	Belongs to the peptidase S11 family
AQF52_RS24645	COG1408	metallophosphoesterase
AQF52_RS24650	COG0747	negative chemotaxis
AQF52_RS24680	COG1846	Transcriptional regulator
AQF52_RS24690	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AQF52_RS24695	COG1053	succinate dehydrogenase
AQF52_RS24705	COG2009	succinate dehydrogenase
AQF52_RS24730	COG1595	DNA-templated transcription, initiation
AQF52_RS24745	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AQF52_RS24745	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AQF52_RS24765	COG1216	Glycosyl transferase, family 2
AQF52_RS24780	COG2089	acid synthase
AQF52_RS24790	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AQF52_RS24790	COG1473	amidohydrolase
AQF52_RS24810	COG1744	ABC transporter substrate-binding protein PnrA-like
AQF52_RS24815	COG3845	ABC transporter
AQF52_RS24820	COG4603	Belongs to the binding-protein-dependent transport system permease family
AQF52_RS24825	COG1079	Belongs to the binding-protein-dependent transport system permease family
AQF52_RS24840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AQF52_RS24860	COG2814	Major facilitator Superfamily
AQF52_RS24865	COG0583	DNA-binding transcription factor activity
AQF52_RS24870	COG2124	cytochrome p450
AQF52_RS24885	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AQF52_RS24910	COG2205	protein histidine kinase activity
AQF52_RS24915	COG0745	RESPONSE REGULATOR receiver
AQF52_RS24920	COG1595	DNA-templated transcription, initiation
AQF52_RS24940	COG1012	belongs to the aldehyde dehydrogenase family
AQF52_RS24945	COG1012	belongs to the aldehyde dehydrogenase family
AQF52_RS25010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AQF52_RS25015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AQF52_RS25035	COG1349	DNA-binding transcription factor activity
AQF52_RS25045	COG4770	biotin carboxylase activity
AQF52_RS25055	COG0424	maF-like protein
AQF52_RS25075	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AQF52_RS25090	COG1024	Enoyl-CoA hydratase
AQF52_RS25100	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AQF52_RS25150	COG2986	histidine ammonia-lyase
AQF52_RS25175	COG1064	alcohol dehydrogenase
AQF52_RS25185	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AQF52_RS25190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AQF52_RS25195	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AQF52_RS25195	COG1672	PFAM Archaeal ATPase
AQF52_RS25285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AQF52_RS25320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AQF52_RS25335	COG0515	serine threonine protein kinase
AQF52_RS25335	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AQF52_RS25340	COG0515	serine threonine protein kinase
AQF52_RS25340	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AQF52_RS25345	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AQF52_RS25355	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AQF52_RS25365	COG3842	ATPase activity
AQF52_RS25375	COG1331	Highly conserved protein containing a thioredoxin domain
AQF52_RS25385	COG1316	TRANSCRIPTIONal
AQF52_RS25430	COG0438	transferase activity, transferring glycosyl groups
AQF52_RS25440	COG0728	peptidoglycan biosynthetic process
AQF52_RS25450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AQF52_RS25455	COG0438	transferase activity, transferring glycosyl groups
AQF52_RS25525	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AQF52_RS25530	COG4195	phage-related replication protein
AQF52_RS25580	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AQF52_RS25595	COG1414	Transcriptional regulator
AQF52_RS25600	COG0251	oxidation-reduction process
AQF52_RS25630	COG2894	cell division
AQF52_RS25675	COG2885	chlorophyll binding
AQF52_RS25700	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AQF52_RS25705	COG0667	Aldo Keto reductase
AQF52_RS25710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AQF52_RS25715	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AQF52_RS25735	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AQF52_RS25740	COG0450	alkyl hydroperoxide reductase
AQF52_RS25765	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AQF52_RS25780	COG0114	fumarate hydratase activity
AQF52_RS25805	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AQF52_RS25805	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AQF52_RS25830	COG0778	Nitroreductase
AQF52_RS25835	COG1722	exodeoxyribonuclease VII activity
AQF52_RS25840	COG1570	exodeoxyribonuclease VII activity
AQF52_RS25845	COG0531	amino acid
AQF52_RS25850	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AQF52_RS25865	COG0012	GTP binding
AQF52_RS25870	COG3629	intracellular signal transduction
AQF52_RS25870	COG3903	Transcriptional regulator
AQF52_RS25920	COG1842	Phage shock protein A
AQF52_RS25940	COG1053	succinate dehydrogenase
AQF52_RS25960	COG1217	gtp-binding protein TYPA
AQF52_RS25970	COG0601	transmembrane transport
AQF52_RS25975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AQF52_RS25980	COG0444	Belongs to the ABC transporter superfamily
AQF52_RS25985	COG4608	Belongs to the ABC transporter superfamily
AQF52_RS25990	COG4166	transmembrane transport
AQF52_RS25995	COG0601	transmembrane transport
AQF52_RS26000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AQF52_RS26005	COG0444	Belongs to the ABC transporter superfamily
AQF52_RS26010	COG4608	Belongs to the ABC transporter superfamily
AQF52_RS26030	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AQF52_RS26065	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AQF52_RS26065	COG0515	serine threonine protein kinase
AQF52_RS26070	COG0515	serine threonine protein kinase
AQF52_RS26070	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AQF52_RS26105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AQF52_RS26110	COG1611	Belongs to the LOG family
AQF52_RS26115	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AQF52_RS26125	COG0519	Catalyzes the synthesis of GMP from XMP
AQF52_RS26135	COG1024	Enoyl-CoA hydratase
AQF52_RS26145	COG1595	DNA-templated transcription, initiation
AQF52_RS26155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AQF52_RS26160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AQF52_RS26195	COG0598	Magnesium transport protein CorA
AQF52_RS26215	COG2095	MarC family integral membrane protein
AQF52_RS26220	COG1432	Conserved Protein
AQF52_RS26230	COG0513	Belongs to the DEAD box helicase family
AQF52_RS26275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AQF52_RS26280	COG0601	transmembrane transport
AQF52_RS26290	COG0438	transferase activity, transferring glycosyl groups
AQF52_RS26355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AQF52_RS26395	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AQF52_RS26445	COG3480	Lon protease (S16) C-terminal proteolytic domain
AQF52_RS26455	COG1615	UPF0182 protein
AQF52_RS26480	COG0753	catalase activity
AQF52_RS26490	COG0483	inositol monophosphate 1-phosphatase activity
AQF52_RS26505	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AQF52_RS26515	COG2135	peptidase activity
AQF52_RS26525	COG1595	DNA-templated transcription, initiation
AQF52_RS26530	COG5662	AntiSigma factor
AQF52_RS26535	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AQF52_RS26535	COG2199	diguanylate cyclase activity
AQF52_RS26550	COG0242	peptide deformylase activity
AQF52_RS26580	COG2188	Transcriptional regulator
AQF52_RS26585	COG2182	Extracellular solute-binding protein
AQF52_RS26590	COG1175	transmembrane transport
AQF52_RS26595	COG0395	ABC-type sugar transport system, permease component
AQF52_RS26600	COG1472	Belongs to the glycosyl hydrolase 3 family
AQF52_RS26605	COG0363	glucosamine-6-phosphate deaminase activity
AQF52_RS26610	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS26630	COG1597	lipid kinase activity
AQF52_RS26660	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AQF52_RS26670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AQF52_RS26675	COG0142	geranyltranstransferase activity
AQF52_RS26700	COG5640	endopeptidase activity
AQF52_RS26735	COG4106	trans-aconitate 2-methyltransferase activity
AQF52_RS26740	COG1126	abc transporter atp-binding protein
AQF52_RS26745	COG0765	amino acid transport
AQF52_RS26750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AQF52_RS26760	COG0604	alcohol dehydrogenase
AQF52_RS26790	COG0508	dehydrogenase complex catalyzes the overall conversion of
AQF52_RS26790	COG0567	Dehydrogenase, E1 component
AQF52_RS26795	COG2205	protein histidine kinase activity
AQF52_RS26800	COG0745	RESPONSE REGULATOR receiver
AQF52_RS26810	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AQF52_RS26825	COG0675	Transposase, IS605 OrfB family
AQF52_RS26850	COG1595	DNA-templated transcription, initiation
AQF52_RS26865	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AQF52_RS26890	COG1846	Transcriptional regulator
AQF52_RS26925	COG0789	Transcriptional regulator
AQF52_RS26945	COG0791	NLP P60 protein
AQF52_RS26945	COG3883	PFAM NLP P60 protein
AQF52_RS26970	COG0768	penicillin binding
AQF52_RS26975	COG0772	Belongs to the SEDS family
AQF52_RS26980	COG2205	protein histidine kinase activity
AQF52_RS27000	COG1793	dna ligase
AQF52_RS27000	COG3285	dna ligase
AQF52_RS27005	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AQF52_RS27015	COG1309	transcriptional regulator
AQF52_RS27040	COG0018	arginyl-trna synthetase
AQF52_RS27040	COG0018	arginyl-trna synthetase
AQF52_RS27045	COG0019	diaminopimelate decarboxylase activity
AQF52_RS27050	COG0460	homoserine dehydrogenase
AQF52_RS27055	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AQF52_RS27060	COG0083	homoserine kinase activity
AQF52_RS27070	COG1316	TRANSCRIPTIONal
AQF52_RS27075	COG0254	rRNA binding
AQF52_RS27080	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AQF52_RS27085	COG2890	protein-(glutamine-N5) methyltransferase activity
AQF52_RS27095	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AQF52_RS27100	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AQF52_RS27120	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AQF52_RS27125	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AQF52_RS27130	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AQF52_RS27135	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AQF52_RS27140	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AQF52_RS27145	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AQF52_RS27150	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AQF52_RS27165	COG2197	response regulator
AQF52_RS27170	COG4585	Histidine kinase
AQF52_RS27200	COG1250	3-hydroxyacyl-CoA dehydrogenase
AQF52_RS27215	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AQF52_RS27270	COG0183	Belongs to the thiolase family
AQF52_RS27320	COG1309	transcriptional regulator
AQF52_RS27360	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AQF52_RS27360	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AQF52_RS27395	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AQF52_RS27400	COG0280	phosphate acetyltransferase
AQF52_RS27400	COG0857	belongs to the CobB CobQ family
AQF52_RS27405	COG0205	6-phosphofructokinase activity
AQF52_RS27425	COG4565	transcriptional regulatory protein
AQF52_RS27430	COG3290	protein histidine kinase activity
AQF52_RS27435	COG1301	dicarboxylic acid transport
AQF52_RS27440	COG0667	Aldo Keto reductase
AQF52_RS27450	COG1522	sequence-specific DNA binding
AQF52_RS27455	COG0789	Transcriptional regulator
AQF52_RS27460	COG3118	belongs to the thioredoxin family
AQF52_RS27470	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AQF52_RS27480	COG0366	Alpha amylase catalytic
AQF52_RS27485	COG0366	Alpha amylase catalytic
AQF52_RS27520	COG0058	SHG alpha-glucan phosphorylase activity
AQF52_RS27525	COG4585	Histidine kinase
AQF52_RS27545	COG0477	Major facilitator Superfamily
AQF52_RS27550	COG1132	(ABC) transporter
AQF52_RS27555	COG1132	(ABC) transporter
AQF52_RS27560	COG1131	(ABC) transporter
AQF52_RS27570	COG4585	Histidine kinase
AQF52_RS27585	COG1376	ErfK ybiS ycfS ynhG family protein
AQF52_RS27605	COG0726	polysaccharide deacetylase
AQF52_RS27640	COG1760	l-serine dehydratase
AQF52_RS27645	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AQF52_RS27650	COG0509	glycine decarboxylation via glycine cleavage system
AQF52_RS27655	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AQF52_RS27680	COG4166	transmembrane transport
AQF52_RS27685	COG0601	transmembrane transport
AQF52_RS27690	COG0444	Belongs to the ABC transporter superfamily
AQF52_RS27695	COG4608	Belongs to the ABC transporter superfamily
AQF52_RS27700	COG2860	membrane
AQF52_RS27720	COG0482	sulfurtransferase activity
AQF52_RS27730	COG1611	Belongs to the LOG family
AQF52_RS27735	COG4221	oxidoreductase activity
AQF52_RS27745	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AQF52_RS27755	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AQF52_RS27760	COG0154	amidase activity
AQF52_RS27770	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AQF52_RS27800	COG3511	phospholipase C
AQF52_RS27805	COG2409	Drug exporters of the RND superfamily
AQF52_RS27810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AQF52_RS27825	COG2197	response regulator
AQF52_RS27830	COG2133	pyrroloquinoline quinone binding
AQF52_RS27835	COG0667	Aldo Keto reductase
AQF52_RS27855	COG0440	acetolactate synthase activity
AQF52_RS27860	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AQF52_RS27865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AQF52_RS27895	COG0506	proline dehydrogenase activity
AQF52_RS27900	COG1012	belongs to the aldehyde dehydrogenase family
AQF52_RS27920	COG1695	Transcriptional regulator
AQF52_RS27930	COG0583	DNA-binding transcription factor activity
AQF52_RS27935	COG0473	3-isopropylmalate dehydrogenase activity
AQF52_RS27940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AQF52_RS27950	COG2957	Belongs to the agmatine deiminase family
AQF52_RS27960	COG1595	DNA-templated transcription, initiation
AQF52_RS27970	COG0477	Major facilitator Superfamily
AQF52_RS27975	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AQF52_RS27985	COG0592	DNA-directed DNA polymerase activity
AQF52_RS28005	COG2353	YceI-like domain
AQF52_RS28015	COG0366	Alpha amylase catalytic
AQF52_RS28015	COG1470	cell adhesion involved in biofilm formation
AQF52_RS28020	COG5492	domain, Protein
AQF52_RS28025	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AQF52_RS28045	COG2018	Roadblock/LC7 domain
AQF52_RS28065	COG2018	Roadblock/LC7 domain
AQF52_RS28070	COG5002	protein histidine kinase activity
AQF52_RS28080	COG0179	Fumarylacetoacetate (FAA) hydrolase
AQF52_RS28085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AQF52_RS28090	COG1011	Hydrolase
AQF52_RS28120	COG1414	Transcriptional regulator
AQF52_RS28125	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AQF52_RS28130	COG0066	3-isopropylmalate dehydratase activity
AQF52_RS28140	COG0776	regulation of translation
AQF52_RS28150	COG1920	GTP binding
AQF52_RS28160	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AQF52_RS28165	COG1181	Belongs to the D-alanine--D-alanine ligase family
AQF52_RS28185	COG0351	phosphomethylpyrimidine kinase
AQF52_RS28190	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AQF52_RS28195	COG1461	Dihydroxyacetone kinase
AQF52_RS28200	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AQF52_RS28205	COG0742	ribosomal rna small subunit methyltransferase
AQF52_RS28210	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AQF52_RS28225	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AQF52_RS28230	COG0571	ribonuclease III activity
AQF52_RS28235	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AQF52_RS28240	COG1733	regulation of RNA biosynthetic process
AQF52_RS28245	COG0655	NAD(P)H dehydrogenase (quinone) activity
AQF52_RS28250	COG2340	Cysteine-rich secretory protein family
AQF52_RS28255	COG1254	Belongs to the acylphosphatase family
AQF52_RS28270	COG0477	Major facilitator Superfamily
AQF52_RS28280	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AQF52_RS28310	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AQF52_RS28320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AQF52_RS28335	COG0228	four-way junction DNA binding
AQF52_RS28340	COG1837	Belongs to the UPF0109 family
AQF52_RS28345	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AQF52_RS28350	COG0336	Belongs to the RNA methyltransferase TrmD family
AQF52_RS28355	COG0335	large ribosomal subunit rRNA binding
AQF52_RS28375	COG0681	Belongs to the peptidase S26 family
AQF52_RS28390	COG0792	nuclease activity
AQF52_RS28405	COG1191	sigma factor activity
AQF52_RS28420	COG0052	Belongs to the universal ribosomal protein uS2 family
AQF52_RS28425	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AQF52_RS28430	COG0528	UMP kinase activity
AQF52_RS28435	COG0233	cytoplasmic translational termination
AQF52_RS28440	COG0575	Belongs to the CDS family
AQF52_RS28445	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AQF52_RS28455	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AQF52_RS28460	COG3842	ATPase activity
AQF52_RS28470	COG4181	ATPase activity
AQF52_RS28475	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AQF52_RS28485	COG1012	belongs to the aldehyde dehydrogenase family
AQF52_RS28515	COG2197	response regulator
AQF52_RS28520	COG4585	Histidine kinase
AQF52_RS28535	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AQF52_RS28555	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AQF52_RS28560	COG3842	ATPase activity
AQF52_RS28565	COG1176	ABC-type spermidine putrescine transport system, permease component I
AQF52_RS28570	COG1177	transmembrane transport
AQF52_RS28575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AQF52_RS28580	COG2409	Drug exporters of the RND superfamily
AQF52_RS28620	COG0697	spore germination
AQF52_RS28625	COG1012	belongs to the aldehyde dehydrogenase family
AQF52_RS28635	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AQF52_RS28640	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AQF52_RS28645	COG0750	zinc metalloprotease
AQF52_RS28650	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AQF52_RS28665	COG0442	prolyl-tRNA aminoacylation
AQF52_RS28670	COG0330	HflC and HflK could
AQF52_RS28690	COG0779	Required for maturation of 30S ribosomal subunits
AQF52_RS28705	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AQF52_RS28715	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AQF52_RS28720	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AQF52_RS28750	COG0601	transmembrane transport
AQF52_RS28755	COG4166	transmembrane transport
AQF52_RS28760	COG0455	bacterial-type flagellum organization
AQF52_RS28775	COG3266	domain, Protein
AQF52_RS28780	COG1404	Belongs to the peptidase S8 family
AQF52_RS28800	COG1674	ftsk spoiiie
AQF52_RS28810	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AQF52_RS28815	COG1185	polyribonucleotide nucleotidyltransferase activity
AQF52_RS28820	COG0612	Peptidase, M16
AQF52_RS28825	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AQF52_RS28845	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AQF52_RS28850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AQF52_RS28855	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AQF52_RS28885	COG2770	Histidine kinase
AQF52_RS28885	COG2208	phosphoserine phosphatase activity
AQF52_RS28900	COG1674	ftsk spoiiie
AQF52_RS28910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AQF52_RS28920	COG1546	Belongs to the CinA family
AQF52_RS28920	COG1058	Belongs to the CinA family
AQF52_RS28925	COG1396	sequence-specific DNA binding
AQF52_RS28930	COG0783	Belongs to the Dps family
AQF52_RS28935	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS28940	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AQF52_RS28945	COG1201	RNA secondary structure unwinding
AQF52_RS28985	COG1271	oxidase subunit
AQF52_RS28990	COG2197	response regulator
AQF52_RS28995	COG4585	Histidine kinase
AQF52_RS29015	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AQF52_RS29035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AQF52_RS29040	COG0765	amino acid transport
AQF52_RS29045	COG0765	amino acid transport
AQF52_RS29050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AQF52_RS29055	COG1126	abc transporter atp-binding protein
AQF52_RS29060	COG0745	RESPONSE REGULATOR receiver
AQF52_RS29105	COG0583	DNA-binding transcription factor activity
AQF52_RS29120	COG2197	response regulator
AQF52_RS29125	COG4585	Histidine kinase
AQF52_RS29130	COG0586	Pfam SNARE associated Golgi protein
AQF52_RS29135	COG0494	nUDIX hydrolase
AQF52_RS29145	COG1349	DNA-binding transcription factor activity
AQF52_RS29150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AQF52_RS29170	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AQF52_RS29180	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AQF52_RS29185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AQF52_RS29195	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AQF52_RS29235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AQF52_RS29240	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AQF52_RS29245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AQF52_RS29290	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AQF52_RS29325	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AQF52_RS29330	COG2186	Transcriptional regulator
AQF52_RS29335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AQF52_RS29350	COG0187	DNA topoisomerase II activity
AQF52_RS29360	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AQF52_RS29370	COG3290	protein histidine kinase activity
AQF52_RS29380	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AQF52_RS29385	COG0612	Peptidase, M16
AQF52_RS29400	COG1802	Transcriptional regulator
AQF52_RS29405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AQF52_RS29425	COG1435	thymidine kinase activity
AQF52_RS29435	COG4977	sequence-specific DNA binding
AQF52_RS29495	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AQF52_RS29505	COG0745	RESPONSE REGULATOR receiver
AQF52_RS29510	COG2205	protein histidine kinase activity
AQF52_RS29535	COG0756	dUTP diphosphatase activity
AQF52_RS29545	COG1136	(ABC) transporter
AQF52_RS29545	COG4591	ABC-type transport system involved in lipoprotein release permease component
AQF52_RS29575	COG0569	domain protein
AQF52_RS29580	COG0531	amino acid
AQF52_RS29585	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AQF52_RS29595	COG2235	arginine
AQF52_RS29630	COG3851	Histidine kinase
AQF52_RS29635	COG2197	response regulator
AQF52_RS29640	COG2890	protein-(glutamine-N5) methyltransferase activity
AQF52_RS29645	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AQF52_RS29655	COG3938	Belongs to the proline racemase family
AQF52_RS29665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AQF52_RS29670	COG1799	cell septum assembly
AQF52_RS29700	COG2040	homocysteine
AQF52_RS29710	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AQF52_RS29765	COG2235	arginine
AQF52_RS29770	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AQF52_RS29780	COG1024	Enoyl-CoA hydratase
AQF52_RS29830	COG0477	Major facilitator Superfamily
AQF52_RS29840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AQF52_RS29855	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AQF52_RS29865	COG1653	transport
AQF52_RS29870	COG1175	transmembrane transport
AQF52_RS29875	COG0395	ABC-type sugar transport system, permease component
AQF52_RS29880	COG1940	carbohydrate kinase activity
AQF52_RS29885	COG4213	ABC transporter substrate-binding protein
AQF52_RS29895	COG4214	carbohydrate transport
AQF52_RS29900	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AQF52_RS29905	COG0531	amino acid
AQF52_RS29915	COG1250	3-hydroxyacyl-CoA dehydrogenase
AQF52_RS29915	COG1024	Enoyl-CoA hydratase
AQF52_RS29920	COG0183	Belongs to the thiolase family
AQF52_RS29930	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AQF52_RS29945	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AQF52_RS29955	COG0446	pyridine nucleotide-disulphide oxidoreductase
AQF52_RS29965	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AQF52_RS29970	COG3253	May function as heme-dependent peroxidase
AQF52_RS29985	COG3220	belongs to the UPF0276 family
AQF52_RS30010	COG1116	anion transmembrane transporter activity
AQF52_RS30030	COG2326	polyphosphate kinase activity
AQF52_RS30060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AQF52_RS30065	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AQF52_RS30095	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS30115	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AQF52_RS30140	COG0346	lactoylglutathione lyase activity
AQF52_RS30155	COG0504	CTP synthase activity
AQF52_RS30250	COG1175	transmembrane transport
AQF52_RS30270	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AQF52_RS30280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AQF52_RS30285	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AQF52_RS30305	COG0529	Catalyzes the synthesis of activated sulfate
AQF52_RS30310	COG0175	sulfate reduction
AQF52_RS30335	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS30415	COG1162	GTPase activity
AQF52_RS30440	COG4974	Belongs to the 'phage' integrase family
AQF52_RS30475	COG1162	GTPase activity
AQF52_RS30500	COG1404	Belongs to the peptidase S8 family
AQF52_RS30510	COG0028	Belongs to the TPP enzyme family
AQF52_RS30530	COG1802	Transcriptional regulator
AQF52_RS30570	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AQF52_RS30575	COG2252	PERMEase
AQF52_RS30590	COG1309	transcriptional regulator
AQF52_RS30595	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS30610	COG0583	DNA-binding transcription factor activity
AQF52_RS30645	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AQF52_RS30670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AQF52_RS30675	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS30680	COG1309	transcriptional regulator
AQF52_RS30690	COG2814	Major facilitator Superfamily
AQF52_RS30710	COG0640	Transcriptional regulator
AQF52_RS30715	COG2814	Major facilitator Superfamily
AQF52_RS30725	COG0477	Major facilitator Superfamily
AQF52_RS30735	COG2066	Belongs to the glutaminase family
AQF52_RS30765	COG0009	L-threonylcarbamoyladenylate synthase
AQF52_RS30780	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AQF52_RS30785	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AQF52_RS30790	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AQF52_RS30800	COG3795	YCII-related domain
AQF52_RS30805	COG4941	Belongs to the sigma-70 factor family
AQF52_RS30815	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AQF52_RS30815	COG2080	2 iron, 2 sulfur cluster binding
AQF52_RS30820	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AQF52_RS30825	COG3835	regulator
AQF52_RS30845	COG1309	transcriptional regulator
AQF52_RS30855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AQF52_RS30885	COG1120	ATPase activity
AQF52_RS30890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AQF52_RS30910	COG1335	isochorismatase
AQF52_RS30915	COG2259	Doxx family
AQF52_RS30920	COG0783	Belongs to the Dps family
AQF52_RS30925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AQF52_RS30960	COG1653	transport
AQF52_RS30965	COG1175	transmembrane transport
AQF52_RS30970	COG0395	ABC-type sugar transport system, permease component
AQF52_RS30975	COG2197	response regulator
AQF52_RS30985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AQF52_RS31000	COG2508	Transcriptional regulator
AQF52_RS31020	COG0598	Magnesium transport protein CorA
AQF52_RS31035	COG2197	response regulator
AQF52_RS31040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AQF52_RS31045	COG0318	PFAM AMP-dependent synthetase and ligase
AQF52_RS31070	COG3960	tartronate-semialdehyde synthase activity
AQF52_RS31090	COG0753	catalase activity
AQF52_RS31095	COG2084	Dehydrogenase
AQF52_RS31100	COG3622	Belongs to the hyi family
AQF52_RS31120	COG2351	hydroxyisourate hydrolase activity
AQF52_RS31130	COG2233	PERMEase
AQF52_RS31140	COG2233	PERMEase
AQF52_RS31170	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AQF52_RS31185	COG0477	Major facilitator Superfamily
AQF52_RS31195	COG2197	response regulator
AQF52_RS31200	COG4585	Histidine kinase
AQF52_RS31215	COG1414	Transcriptional regulator
AQF52_RS31220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AQF52_RS31225	COG4266	Belongs to the allantoicase family
AQF52_RS31230	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS31255	COG2203	Gaf domain
AQF52_RS31255	COG4585	Histidine kinase
AQF52_RS31270	COG0673	inositol 2-dehydrogenase activity
AQF52_RS31275	COG2188	Transcriptional regulator
AQF52_RS31290	COG1129	ABC transporter
AQF52_RS31295	COG1940	carbohydrate kinase activity
AQF52_RS31305	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AQF52_RS31320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AQF52_RS31320	COG4221	oxidoreductase activity
AQF52_RS31320	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS31320	COG3321	synthase
AQF52_RS31340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AQF52_RS31345	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AQF52_RS31360	COG1126	abc transporter atp-binding protein
AQF52_RS31365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AQF52_RS31370	COG0765	amino acid transport
AQF52_RS31375	COG0765	amino acid transport
AQF52_RS31400	COG0405	Gamma-glutamyltransferase
AQF52_RS31445	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AQF52_RS31485	COG0483	inositol monophosphate 1-phosphatase activity
AQF52_RS31495	COG0009	L-threonylcarbamoyladenylate synthase
AQF52_RS31500	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AQF52_RS31510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AQF52_RS31515	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AQF52_RS31535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AQF52_RS31540	COG1929	Belongs to the glycerate kinase type-1 family
AQF52_RS31560	COG0559	Belongs to the binding-protein-dependent transport system permease family
AQF52_RS31565	COG0559	Belongs to the binding-protein-dependent transport system permease family
AQF52_RS31590	COG0688	phosphatidylethanolamine metabolic process
AQF52_RS31595	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS31610	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AQF52_RS31610	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AQF52_RS31615	COG0604	alcohol dehydrogenase
AQF52_RS31625	COG1250	3-hydroxyacyl-CoA dehydrogenase
AQF52_RS31640	COG0477	Major facilitator Superfamily
AQF52_RS31670	COG2362	D-Aminopeptidase
AQF52_RS31675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AQF52_RS31680	COG4946	Tricorn protease homolog
AQF52_RS31680	COG1506	peptidase
AQF52_RS31680	COG0823	Involved in the tonB-independent uptake of proteins
AQF52_RS31685	COG1619	proteins homologs of microcin C7 resistance protein MccF
AQF52_RS31690	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AQF52_RS31735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AQF52_RS31745	COG2226	methyltransferase
AQF52_RS31815	COG2154	pterin-4-alpha-carbinolamine dehydratase
AQF52_RS31825	COG2378	regulation of single-species biofilm formation
AQF52_RS31830	COG0702	epimerase
AQF52_RS31840	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AQF52_RS31850	COG0656	L-ascorbic acid biosynthetic process
AQF52_RS31885	COG1335	isochorismatase
AQF52_RS31900	COG0789	Transcriptional regulator
AQF52_RS31905	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AQF52_RS31910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AQF52_RS31930	COG1129	ABC transporter
AQF52_RS31935	COG1172	Belongs to the binding-protein-dependent transport system permease family
AQF52_RS31945	COG0673	inositol 2-dehydrogenase activity
AQF52_RS32005	COG2824	Alkylphosphonate utilization operon protein PhnA
AQF52_RS32045	COG1486	melibiose metabolic process
AQF52_RS32050	COG3012	SEC-C Motif Domain Protein
AQF52_RS32065	COG1793	dna ligase
AQF52_RS32105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AQF52_RS32110	COG1116	anion transmembrane transporter activity
AQF52_RS32115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AQF52_RS32120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AQF52_RS32150	COG0488	(ABC) transporter
AQF52_RS32175	COG1515	deoxyribonuclease V activity
AQF52_RS32185	COG3268	Saccharopine dehydrogenase
AQF52_RS32190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AQF52_RS32195	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS32200	COG0183	Belongs to the thiolase family
AQF52_RS32205	COG1250	3-hydroxyacyl-CoA dehydrogenase
AQF52_RS32205	COG1024	Enoyl-CoA hydratase
AQF52_RS32230	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AQF52_RS32245	COG2936	dipeptidyl-peptidase activity
AQF52_RS32270	COG0488	(ABC) transporter
AQF52_RS32285	COG2183	response to ionizing radiation
AQF52_RS32295	COG4977	sequence-specific DNA binding
AQF52_RS32305	COG1024	Enoyl-CoA hydratase
AQF52_RS32315	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AQF52_RS32360	COG1388	LysM domain
AQF52_RS32360	COG1134	teichoic acid transport
AQF52_RS32370	COG1562	ergosterol biosynthetic process
AQF52_RS32380	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AQF52_RS32390	COG1657	PFAM Prenyltransferase squalene oxidase
AQF52_RS32415	COG2365	Tyrosine phosphatase family
AQF52_RS32420	COG0739	heme binding
AQF52_RS32425	COG2755	lipolytic protein G-D-S-L family
AQF52_RS32435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AQF52_RS32475	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AQF52_RS32520	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS32530	COG0673	inositol 2-dehydrogenase activity
AQF52_RS32545	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AQF52_RS32550	COG1105	Belongs to the carbohydrate kinase PfkB family
AQF52_RS32555	COG1940	carbohydrate kinase activity
AQF52_RS32560	COG1349	DNA-binding transcription factor activity
AQF52_RS32575	COG0395	ABC-type sugar transport system, permease component
AQF52_RS32600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AQF52_RS32605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AQF52_RS32610	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AQF52_RS32625	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AQF52_RS32635	COG0142	geranyltranstransferase activity
AQF52_RS32645	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AQF52_RS32680	COG3591	Belongs to the peptidase S1B family
AQF52_RS32680	COG1864	DNA RNA non-specific endonuclease
AQF52_RS32695	COG1404	Belongs to the peptidase S8 family
AQF52_RS32730	COG3189	MarR family transcriptional regulator
AQF52_RS32740	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AQF52_RS32755	COG2175	clavaminate synthase activity
AQF52_RS32770	COG0300	oxidoreductase activity
AQF52_RS32800	COG0494	nUDIX hydrolase
AQF52_RS32815	COG1940	carbohydrate kinase activity
AQF52_RS32820	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AQF52_RS32825	COG0395	ABC-type sugar transport system, permease component
AQF52_RS32845	COG1609	Transcriptional regulator
AQF52_RS32850	COG1609	Transcriptional regulator
AQF52_RS32925	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AQF52_RS32935	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AQF52_RS32940	COG2211	Major facilitator Superfamily
AQF52_RS32970	COG3764	Sortase (surface protein transpeptidase)
AQF52_RS32975	COG0644	oxidoreductase
AQF52_RS33000	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AQF52_RS33005	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AQF52_RS33030	COG3903	Transcriptional regulator
AQF52_RS33030	COG2197	response regulator
AQF52_RS33065	COG1846	Transcriptional regulator
AQF52_RS33075	COG2353	YceI-like domain
AQF52_RS33095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AQF52_RS33105	COG2264	protein methyltransferase activity
AQF52_RS33115	COG0514	ATP-dependent DNA helicase (RecQ)
AQF52_RS33120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AQF52_RS33130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AQF52_RS33145	COG0584	glycerophosphoryl diester phosphodiesterase
AQF52_RS33150	COG0789	Transcriptional regulator
AQF52_RS33165	COG0395	ABC-type sugar transport system, permease component
AQF52_RS33170	COG1175	transmembrane transport
AQF52_RS33185	COG5297	Belongs to the glycosyl hydrolase family 6
AQF52_RS33195	COG5297	Belongs to the glycosyl hydrolase family 6
AQF52_RS33195	COG4733	cellulase activity
AQF52_RS33205	COG1653	transport
AQF52_RS33210	COG1175	transmembrane transport
AQF52_RS33215	COG0395	ABC-type sugar transport system, permease component
AQF52_RS33245	COG1595	DNA-templated transcription, initiation
AQF52_RS33265	COG1695	Transcriptional regulator
AQF52_RS33285	COG4677	pectinesterase activity
AQF52_RS33290	COG3866	Pectate lyase
AQF52_RS33295	COG2755	lipolytic protein G-D-S-L family
AQF52_RS33300	COG1653	transport
AQF52_RS33305	COG3507	Belongs to the glycosyl hydrolase 43 family
AQF52_RS33320	COG0395	ABC-type sugar transport system, permease component
AQF52_RS33340	COG1802	Transcriptional regulator
AQF52_RS33345	COG1501	Belongs to the glycosyl hydrolase 31 family
AQF52_RS33385	COG1472	Belongs to the glycosyl hydrolase 3 family
AQF52_RS33395	COG4209	transmembrane transport
AQF52_RS33400	COG0395	ABC-type sugar transport system, permease component
AQF52_RS33415	COG1609	Transcriptional regulator
AQF52_RS33440	COG1414	Transcriptional regulator
AQF52_RS33445	COG1940	carbohydrate kinase activity
AQF52_RS33450	COG4948	Mandelate Racemase Muconate Lactonizing
AQF52_RS33455	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AQF52_RS33485	COG1175	transmembrane transport
AQF52_RS33490	COG0395	ABC-type sugar transport system, permease component
AQF52_RS33500	COG1556	Lactate utilization protein
AQF52_RS33505	COG1139	Iron-sulfur cluster binding protein
AQF52_RS33510	COG0247	lactate metabolic process
AQF52_RS33515	COG1070	Carbohydrate kinase
AQF52_RS33520	COG3347	Dehydrogenase
AQF52_RS33520	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS33530	COG3254	rhamnose metabolic process
AQF52_RS33535	COG1609	Transcriptional regulator
AQF52_RS33610	COG1136	(ABC) transporter
AQF52_RS33665	COG2124	cytochrome p450
AQF52_RS33675	COG3458	cephalosporin-C deacetylase activity
AQF52_RS33700	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AQF52_RS33760	COG2826	transposase and inactivated derivatives, IS30 family
AQF52_RS33775	COG3220	belongs to the UPF0276 family
AQF52_RS33820	COG0515	serine threonine protein kinase
AQF52_RS33905	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
AQF52_RS33915	COG4948	Mandelate Racemase Muconate Lactonizing
AQF52_RS33920	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS33935	COG3386	PFAM SMP-30 Gluconolaconase
AQF52_RS33945	COG1940	carbohydrate kinase activity
AQF52_RS34000	COG0667	Aldo Keto reductase
AQF52_RS34005	COG1132	(ABC) transporter
AQF52_RS34010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AQF52_RS34015	COG1116	anion transmembrane transporter activity
AQF52_RS34020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AQF52_RS34030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AQF52_RS34040	COG2175	clavaminate synthase activity
AQF52_RS34055	COG0582	viral genome integration into host DNA
AQF52_RS34060	COG0277	FAD linked oxidase domain protein
AQF52_RS34095	COG2326	polyphosphate kinase activity
AQF52_RS34110	COG1136	(ABC) transporter
AQF52_RS34110	COG0577	efflux transmembrane transporter activity
AQF52_RS34115	COG1136	(ABC) transporter
AQF52_RS34135	COG0659	secondary active sulfate transmembrane transporter activity
AQF52_RS34145	COG2824	Alkylphosphonate utilization operon protein PhnA
AQF52_RS34160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AQF52_RS34170	COG1937	Protein conserved in bacteria
AQF52_RS34190	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AQF52_RS34195	COG3383	formate dehydrogenase (NAD+) activity
AQF52_RS34205	COG2239	Acts as a magnesium transporter
AQF52_RS34215	COG0508	dehydrogenase complex catalyzes the overall conversion of
AQF52_RS34220	COG0022	dehydrogenase e1 component
AQF52_RS34220	COG0508	dehydrogenase complex catalyzes the overall conversion of
AQF52_RS34225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AQF52_RS34230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AQF52_RS34235	COG0517	IMP dehydrogenase activity
AQF52_RS34235	COG0516	GMP reductase activity
AQF52_RS34245	COG2239	Acts as a magnesium transporter
AQF52_RS34265	COG2217	Heavy metal translocating P-type atpase
AQF52_RS34285	COG0574	Belongs to the PEP-utilizing enzyme family
AQF52_RS34285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AQF52_RS34295	COG0071	Belongs to the small heat shock protein (HSP20) family
AQF52_RS34310	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AQF52_RS34320	COG2239	Acts as a magnesium transporter
AQF52_RS34325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AQF52_RS34335	COG0517	IMP dehydrogenase activity
AQF52_RS34335	COG0516	GMP reductase activity
AQF52_RS34340	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AQF52_RS34345	COG1063	alcohol dehydrogenase
AQF52_RS34350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AQF52_RS34395	COG0517	IMP dehydrogenase activity
AQF52_RS34395	COG0516	GMP reductase activity
AQF52_RS34430	COG4122	O-methyltransferase activity
AQF52_RS34435	COG1222	aaa ATPase
AQF52_RS34460	COG0297	glycogen (starch) synthase activity
AQF52_RS34480	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AQF52_RS34520	COG2268	Band 7 protein
AQF52_RS34525	COG1585	Membrane protein implicated in regulation of membrane protease activity
AQF52_RS34535	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AQF52_RS34540	COG0569	domain protein
AQF52_RS34565	COG1131	(ABC) transporter
AQF52_RS34595	COG2255	four-way junction helicase activity
AQF52_RS34605	COG1115	amino acid carrier protein
AQF52_RS34610	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AQF52_RS34700	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AQF52_RS34740	COG2205	protein histidine kinase activity
AQF52_RS34895	COG0305	Participates in initiation and elongation during chromosome replication
AQF52_RS34975	COG1074	ATP-dependent DNA helicase activity
AQF52_RS34980	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AQF52_RS35005	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AQF52_RS35060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AQF52_RS35075	COG0745	RESPONSE REGULATOR receiver
AQF52_RS35090	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AQF52_RS35105	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AQF52_RS35110	COG3275	phosphorelay sensor kinase activity
AQF52_RS35190	COG1053	succinate dehydrogenase
AQF52_RS35195	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AQF52_RS35240	COG2182	Extracellular solute-binding protein
AQF52_RS35255	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AQF52_RS35260	COG0121	glutamine amidotransferase
AQF52_RS35265	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AQF52_RS35285	COG2268	Band 7 protein
AQF52_RS35305	COG1609	Transcriptional regulator
AQF52_RS35315	COG0183	Belongs to the thiolase family
AQF52_RS35320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AQF52_RS35325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AQF52_RS35380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AQF52_RS35395	COG2890	protein-(glutamine-N5) methyltransferase activity
AQF52_RS35400	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AQF52_RS35435	COG1250	3-hydroxyacyl-CoA dehydrogenase
AQF52_RS35445	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS35460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AQF52_RS35485	COG0823	Involved in the tonB-independent uptake of proteins
AQF52_RS35485	COG1506	peptidase
AQF52_RS35495	COG0431	NADPH-dependent FMN reductase
AQF52_RS35530	COG2124	cytochrome p450
AQF52_RS35630	COG4865	methylaspartate mutase activity
AQF52_RS35635	COG0017	Asparaginyl-tRNA synthetase
AQF52_RS35640	COG0069	glutamate synthase activity
AQF52_RS35650	COG0154	amidase activity
AQF52_RS35655	COG3251	PFAM MbtH domain protein
AQF52_RS35675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AQF52_RS35680	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AQF52_RS35690	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AQF52_RS35705	COG3629	intracellular signal transduction
AQF52_RS35705	COG3903	Transcriptional regulator
AQF52_RS35720	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS35725	COG2124	cytochrome p450
AQF52_RS35735	COG3629	intracellular signal transduction
AQF52_RS35735	COG3903	Transcriptional regulator
AQF52_RS35780	COG3321	synthase
AQF52_RS35780	COG0604	alcohol dehydrogenase
AQF52_RS35780	COG3321	synthase
AQF52_RS35780	COG0604	alcohol dehydrogenase
AQF52_RS35785	COG0604	alcohol dehydrogenase
AQF52_RS35785	COG3321	synthase
AQF52_RS35815	COG3552	Protein containing von Willebrand factor type A (VWA) domain
AQF52_RS35820	COG0714	Associated with various cellular activities
AQF52_RS35830	COG2045	Belongs to the ComB family
AQF52_RS35875	COG1278	Cold shock
AQF52_RS35880	COG0513	Belongs to the DEAD box helicase family
AQF52_RS35905	COG1720	tRNA m6t6A37 methyltransferase activity
AQF52_RS35915	COG2205	protein histidine kinase activity
AQF52_RS35930	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AQF52_RS35930	COG0825	malonyl-CoA metabolic process
AQF52_RS35965	COG1126	abc transporter atp-binding protein
AQF52_RS35970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AQF52_RS35975	COG0765	amino acid transport
AQF52_RS35980	COG0765	amino acid transport
AQF52_RS36000	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AQF52_RS36010	COG1174	glycine betaine transport
AQF52_RS36015	COG1174	glycine betaine transport
AQF52_RS36040	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AQF52_RS36060	COG0492	ferredoxin-NADP+ reductase activity
AQF52_RS36075	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS36080	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS36090	COG0601	transmembrane transport
AQF52_RS36095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AQF52_RS36100	COG0444	Belongs to the ABC transporter superfamily
AQF52_RS36140	COG3387	PFAM Glycoside hydrolase 15-related
AQF52_RS36155	COG1271	oxidase subunit
AQF52_RS36160	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS36175	COG3265	gluconokinase activity
AQF52_RS36190	COG2271	Major facilitator Superfamily
AQF52_RS36245	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AQF52_RS36255	COG2226	methyltransferase
AQF52_RS36285	COG4974	Belongs to the 'phage' integrase family
AQF52_RS36345	COG0366	Alpha amylase catalytic
AQF52_RS36345	COG1874	Beta-galactosidase
AQF52_RS36365	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AQF52_RS36370	COG1116	anion transmembrane transporter activity
AQF52_RS36370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AQF52_RS36375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AQF52_RS36380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AQF52_RS36390	COG2188	Transcriptional regulator
AQF52_RS36410	COG0444	Belongs to the ABC transporter superfamily
AQF52_RS36415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AQF52_RS36425	COG0747	negative chemotaxis
AQF52_RS36430	COG1609	Transcriptional regulator
AQF52_RS36465	COG3250	beta-galactosidase activity
AQF52_RS36470	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
AQF52_RS36490	COG0395	ABC-type sugar transport system, permease component
AQF52_RS36495	COG1175	transmembrane transport
AQF52_RS36515	COG0402	S-adenosylhomocysteine deaminase activity
AQF52_RS36520	COG1802	Transcriptional regulator
AQF52_RS36535	COG0395	ABC-type sugar transport system, permease component
AQF52_RS36545	COG1653	transport
AQF52_RS36555	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AQF52_RS36580	COG0243	molybdopterin cofactor binding
AQF52_RS36590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AQF52_RS36600	COG4214	carbohydrate transport
AQF52_RS36610	COG4213	ABC transporter substrate-binding protein
AQF52_RS36615	COG0318	PFAM AMP-dependent synthetase and ligase
AQF52_RS36665	COG1414	Transcriptional regulator
AQF52_RS36680	COG0183	Belongs to the thiolase family
AQF52_RS36685	COG3485	protocatechuate 3,4-dioxygenase
AQF52_RS36690	COG3485	protocatechuate 3,4-dioxygenase
AQF52_RS36695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AQF52_RS36700	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AQF52_RS36710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AQF52_RS36720	COG4585	Histidine kinase
AQF52_RS36730	COG0659	secondary active sulfate transmembrane transporter activity
AQF52_RS36735	COG1231	oxidoreductase activity
AQF52_RS36740	COG3973	AAA domain
AQF52_RS36745	COG1846	Transcriptional regulator
AQF52_RS36785	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AQF52_RS36790	COG1653	transport
AQF52_RS36800	COG0395	ABC-type sugar transport system, permease component
AQF52_RS36880	COG0583	DNA-binding transcription factor activity
AQF52_RS36905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AQF52_RS36910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AQF52_RS36925	COG1309	transcriptional regulator
AQF52_RS36935	COG2205	protein histidine kinase activity
AQF52_RS36940	COG0745	RESPONSE REGULATOR receiver
AQF52_RS36955	COG1136	(ABC) transporter
AQF52_RS36955	COG0577	efflux transmembrane transporter activity
AQF52_RS36960	COG0577	efflux transmembrane transporter activity
AQF52_RS36960	COG1136	(ABC) transporter
AQF52_RS36965	COG0832	Belongs to the urease beta subunit family
AQF52_RS36965	COG0831	urea catabolic process
AQF52_RS36970	COG0804	urea catabolic process
AQF52_RS36980	COG0747	negative chemotaxis
AQF52_RS36995	COG0444	Belongs to the ABC transporter superfamily
AQF52_RS37000	COG4608	Belongs to the ABC transporter superfamily
AQF52_RS37010	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AQF52_RS37030	COG0308	aminopeptidase N
AQF52_RS37045	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AQF52_RS37055	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AQF52_RS37065	COG1309	transcriptional regulator
AQF52_RS37075	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AQF52_RS37075	COG1672	PFAM Archaeal ATPase
AQF52_RS37085	COG0154	amidase activity
AQF52_RS37090	COG1428	Deoxynucleoside kinase
AQF52_RS37100	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AQF52_RS37115	COG1215	transferase activity, transferring glycosyl groups
AQF52_RS37125	COG4310	Domain of unknown function (DUF2172)
AQF52_RS37135	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AQF52_RS37140	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AQF52_RS37150	COG0438	transferase activity, transferring glycosyl groups
AQF52_RS37195	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AQF52_RS37200	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AQF52_RS37215	COG2226	methyltransferase
AQF52_RS37225	COG4981	capsule polysaccharide biosynthetic process
AQF52_RS37260	COG1073	alpha beta
AQF52_RS37265	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AQF52_RS37280	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AQF52_RS37285	COG3239	Fatty acid desaturase
AQF52_RS37335	COG2018	Roadblock/LC7 domain
AQF52_RS37345	COG1793	dna ligase
AQF52_RS37355	COG0726	polysaccharide deacetylase
AQF52_RS37375	COG1017	nitric oxide dioxygenase activity
AQF52_RS37375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AQF52_RS37380	COG1959	2 iron, 2 sulfur cluster binding
AQF52_RS37415	COG1376	ErfK ybiS ycfS ynhG family protein
AQF52_RS37435	COG2814	Major facilitator Superfamily
AQF52_RS37440	COG0583	DNA-binding transcription factor activity
AQF52_RS37445	COG1473	amidohydrolase
AQF52_RS37460	COG0477	Major facilitator Superfamily
AQF52_RS37475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AQF52_RS37480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AQF52_RS37490	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AQF52_RS37500	COG0542	response to heat
AQF52_RS37540	COG4585	Histidine kinase
AQF52_RS37545	COG2197	response regulator
AQF52_RS37550	COG1051	belongs to the nudix hydrolase family
AQF52_RS37575	COG0702	epimerase
AQF52_RS37580	COG0254	rRNA binding
AQF52_RS37595	COG0589	response to stress
AQF52_RS37620	COG3511	phospholipase C
AQF52_RS37635	COG1349	DNA-binding transcription factor activity
AQF52_RS37660	COG4977	sequence-specific DNA binding
AQF52_RS37680	COG2205	protein histidine kinase activity
AQF52_RS37685	COG0745	RESPONSE REGULATOR receiver
AQF52_RS37700	COG0577	efflux transmembrane transporter activity
AQF52_RS37700	COG1136	(ABC) transporter
AQF52_RS37705	COG0577	efflux transmembrane transporter activity
AQF52_RS37705	COG1136	(ABC) transporter
AQF52_RS37815	COG2197	response regulator
AQF52_RS37820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AQF52_RS37825	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AQF52_RS37835	COG0477	Major facilitator Superfamily
AQF52_RS37865	COG1902	pentaerythritol trinitrate reductase activity
AQF52_RS37875	COG0154	amidase activity
AQF52_RS37940	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS37945	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS37950	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS37955	COG1024	Enoyl-CoA hydratase
AQF52_RS37960	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS37970	COG1309	transcriptional regulator
AQF52_RS37975	COG0183	Belongs to the thiolase family
AQF52_RS38000	COG1024	Enoyl-CoA hydratase
AQF52_RS38010	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS38015	COG3971	2-oxopent-4-enoate hydratase activity
AQF52_RS38025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AQF52_RS38055	COG1414	Transcriptional regulator
AQF52_RS38065	COG1960	acyl-CoA dehydrogenase activity
AQF52_RS38080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AQF52_RS38085	COG1053	succinate dehydrogenase
AQF52_RS38100	COG2072	flavoprotein involved in K transport
AQF52_RS38105	COG0318	PFAM AMP-dependent synthetase and ligase
AQF52_RS38110	COG0666	response to abiotic stimulus
AQF52_RS38135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AQF52_RS38135	COG0723	plastoquinol--plastocyanin reductase activity
AQF52_RS38140	COG0697	spore germination
AQF52_RS38165	COG1476	TRANSCRIPTIONal
AQF52_RS38200	COG1595	DNA-templated transcription, initiation
AQF52_RS38205	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AQF52_RS38215	COG3655	Transcriptional regulator
AQF52_RS38245	COG4941	Belongs to the sigma-70 factor family
AQF52_RS38250	COG3795	YCII-related domain
AQF52_RS38270	COG3629	intracellular signal transduction
AQF52_RS38280	COG4585	Histidine kinase
AQF52_RS38285	COG2409	Drug exporters of the RND superfamily
AQF52_RS38340	COG1028	Short-chain dehydrogenase reductase Sdr
AQF52_RS38370	COG2205	protein histidine kinase activity
AQF52_RS38375	COG0745	RESPONSE REGULATOR receiver
AQF52_RS38385	COG1132	(ABC) transporter
AQF52_RS38445	COG1653	transport
AQF52_RS38450	COG1175	transmembrane transport
AQF52_RS38455	COG0395	ABC-type sugar transport system, permease component
AQF52_RS38460	COG0366	Alpha amylase catalytic
AQF52_RS38510	COG2340	Cysteine-rich secretory protein family
AQF52_RS38525	COG2197	response regulator
AQF52_RS38540	COG0702	epimerase
AQF52_RS38575	COG3119	arylsulfatase activity
AQF52_RS38585	COG0702	epimerase
AQF52_RS38615	COG2207	Transcriptional regulator
AQF52_RS38615	COG3708	Transcriptional regulator
AQF52_RS38645	COG3293	Transposase
AQF52_RS38685	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AQF52_RS38700	COG0148	phosphopyruvate hydratase activity
AQF52_RS38745	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AQF52_RS38810	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AQF52_RS38835	COG1401	restriction endodeoxyribonuclease activity
AQF52_RS38905	COG0531	amino acid
AQF52_RS38920	COG0596	Alpha beta hydrolase
AQF52_RS38955	COG2964	Protein conserved in bacteria
AQF52_RS38960	COG2814	Major facilitator Superfamily
AQF52_RS38990	COG1472	Belongs to the glycosyl hydrolase 3 family
AQF52_RS39110	COG2813	Specifically methylates the guanine in position
AQF52_RS39210	COG0539	negative regulation of cytoplasmic translation
AQF52_RS39305	COG1408	metallophosphoesterase
AQF52_RS39310	COG1309	transcriptional regulator
AQF52_RS39315	COG0277	FAD linked oxidase domain protein
AQF52_RS39400	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AQF52_RS39420	COG2205	protein histidine kinase activity
AQF52_RS39430	COG0785	Cytochrome C biogenesis protein
AQF52_RS39435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AQF52_RS39465	COG0745	RESPONSE REGULATOR receiver
AQF52_RS39480	COG2205	protein histidine kinase activity
AQF52_RS39485	COG0745	RESPONSE REGULATOR receiver
AQF52_RS39515	COG1846	Transcriptional regulator
AQF52_RS39520	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AQF52_RS39555	COG0667	Aldo Keto reductase
AQF52_RS39580	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AQF52_RS39625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AQF52_RS39645	COG0587	DNA-directed DNA polymerase activity
AQF52_RS39700	COG2226	methyltransferase
AQF52_RS39765	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AQF52_RS39850	COG3293	Transposase
AQF52_RS39905	COG0539	negative regulation of cytoplasmic translation
AQF52_RS39945	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AQF52_RS39945	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds