locus-tag	class	description
HWN34_RS00085	COG2205	protein histidine kinase activity
HWN34_RS00090	COG0745	RESPONSE REGULATOR receiver
HWN34_RS00095	COG0577	efflux transmembrane transporter activity
HWN34_RS00105	COG1136	(ABC) transporter
HWN34_RS00135	COG3386	PFAM SMP-30 Gluconolaconase
HWN34_RS00140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWN34_RS00145	COG0800	Aldolase
HWN34_RS00150	COG4948	Mandelate Racemase Muconate Lactonizing
HWN34_RS00155	COG2186	Transcriptional regulator
HWN34_RS00165	COG1063	alcohol dehydrogenase
HWN34_RS00170	COG1172	Belongs to the binding-protein-dependent transport system permease family
HWN34_RS00175	COG1129	ABC transporter
HWN34_RS00180	COG1879	ABC-type sugar transport system periplasmic component
HWN34_RS00205	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HWN34_RS00220	COG1063	alcohol dehydrogenase
HWN34_RS00250	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HWN34_RS00255	COG4977	sequence-specific DNA binding
HWN34_RS00275	COG1472	Belongs to the glycosyl hydrolase 3 family
HWN34_RS00280	COG1874	Beta-galactosidase
HWN34_RS00285	COG1609	Transcriptional regulator
HWN34_RS00290	COG0395	ABC-type sugar transport system, permease component
HWN34_RS00295	COG1175	transmembrane transport
HWN34_RS00315	COG1028	Short-chain dehydrogenase reductase Sdr
HWN34_RS00320	COG0477	Major facilitator Superfamily
HWN34_RS00345	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HWN34_RS00350	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HWN34_RS00355	COG2080	2 iron, 2 sulfur cluster binding
HWN34_RS00365	COG2197	response regulator
HWN34_RS00370	COG4585	Histidine kinase
HWN34_RS00375	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HWN34_RS00450	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HWN34_RS00450	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWN34_RS00500	COG4608	Belongs to the ABC transporter superfamily
HWN34_RS00505	COG0444	Belongs to the ABC transporter superfamily
HWN34_RS00510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HWN34_RS00515	COG0601	transmembrane transport
HWN34_RS00520	COG0747	negative chemotaxis
HWN34_RS00530	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HWN34_RS00550	COG1793	dna ligase
HWN34_RS00585	COG0277	FAD linked oxidase domain protein
HWN34_RS00640	COG0318	PFAM AMP-dependent synthetase and ligase
HWN34_RS00645	COG0589	response to stress
HWN34_RS00650	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HWN34_RS00655	COG2813	Specifically methylates the guanine in position
HWN34_RS00665	COG2356	endonuclease I
HWN34_RS00715	COG2084	Dehydrogenase
HWN34_RS00730	COG2267	carboxylic ester hydrolase activity
HWN34_RS00750	COG1007	ATP synthesis coupled electron transport
HWN34_RS00755	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HWN34_RS00760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HWN34_RS00765	COG0713	ATP synthesis coupled electron transport
HWN34_RS00775	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HWN34_RS00785	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HWN34_RS00805	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWN34_RS00805	COG1902	pentaerythritol trinitrate reductase activity
HWN34_RS00815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HWN34_RS00850	COG0475	glutathione-regulated potassium exporter activity
HWN34_RS00870	COG2197	response regulator
HWN34_RS00885	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HWN34_RS00900	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HWN34_RS00910	COG3268	Saccharopine dehydrogenase
HWN34_RS00935	COG0477	Major facilitator Superfamily
HWN34_RS00950	COG0328	RNA-DNA hybrid ribonuclease activity
HWN34_RS00955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWN34_RS00960	COG3547	Transposase (IS116 IS110 IS902 family)
HWN34_RS00965	COG0431	NADPH-dependent FMN reductase
HWN34_RS00995	COG1595	DNA-templated transcription, initiation
HWN34_RS01020	COG0667	Aldo Keto reductase
HWN34_RS01050	COG1028	Short-chain dehydrogenase reductase Sdr
HWN34_RS01055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HWN34_RS01060	COG1131	(ABC) transporter
HWN34_RS01080	COG0326	Molecular chaperone. Has ATPase activity
HWN34_RS01110	COG0346	lactoylglutathione lyase activity
HWN34_RS01115	COG0640	Transcriptional regulator
HWN34_RS01130	COG1120	ATPase activity
HWN34_RS01150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HWN34_RS01160	COG1960	acyl-CoA dehydrogenase activity
HWN34_RS01170	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWN34_RS01180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWN34_RS01195	COG1349	DNA-binding transcription factor activity
HWN34_RS01205	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HWN34_RS01205	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HWN34_RS01205	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HWN34_RS01210	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWN34_RS01210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HWN34_RS01215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HWN34_RS01240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HWN34_RS01260	COG2226	methyltransferase
HWN34_RS01270	COG1695	Transcriptional regulator
HWN34_RS01295	COG1028	Short-chain dehydrogenase reductase Sdr
HWN34_RS01310	COG0513	Belongs to the DEAD box helicase family
HWN34_RS01320	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HWN34_RS01335	COG3217	Mosc domain protein beta barrel domain protein
HWN34_RS01335	COG0633	Ferredoxin
HWN34_RS01355	COG1349	DNA-binding transcription factor activity
HWN34_RS01375	COG1940	carbohydrate kinase activity
HWN34_RS01385	COG2223	nitrite transmembrane transporter activity
HWN34_RS01400	COG2197	response regulator
HWN34_RS01410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HWN34_RS01415	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HWN34_RS01440	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HWN34_RS01480	COG0584	glycerophosphoryl diester phosphodiesterase
HWN34_RS01495	COG1846	Transcriptional regulator
HWN34_RS01515	COG0671	phosphoesterase, PA-phosphatase related
HWN34_RS01545	COG2233	PERMEase
HWN34_RS01550	COG0640	Transcriptional regulator
HWN34_RS01555	COG1902	pentaerythritol trinitrate reductase activity
HWN34_RS01570	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HWN34_RS01585	COG2706	6-phosphogluconolactonase activity
HWN34_RS01595	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HWN34_RS01600	COG0071	Belongs to the small heat shock protein (HSP20) family
HWN34_RS01605	COG0076	glutamate decarboxylase activity
HWN34_RS01610	COG0243	molybdopterin cofactor binding
HWN34_RS01625	COG0303	'Molybdopterin
HWN34_RS01630	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HWN34_RS01650	COG0583	DNA-binding transcription factor activity
HWN34_RS01675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HWN34_RS01695	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HWN34_RS01700	COG1120	ATPase activity
HWN34_RS01705	COG2207	Transcriptional regulator
HWN34_RS01710	COG2814	Major facilitator Superfamily
HWN34_RS01740	COG0477	Major facilitator Superfamily
HWN34_RS01745	COG1309	transcriptional regulator
HWN34_RS01755	COG1472	Belongs to the glycosyl hydrolase 3 family
HWN34_RS01765	COG1175	transmembrane transport
HWN34_RS01775	COG1609	Transcriptional regulator
HWN34_RS01780	COG0432	Pfam Uncharacterised protein family UPF0047
HWN34_RS01785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWN34_RS01790	COG1116	anion transmembrane transporter activity
HWN34_RS01800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWN34_RS01805	COG0492	ferredoxin-NADP+ reductase activity
HWN34_RS01810	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HWN34_RS01815	COG1132	(ABC) transporter
HWN34_RS01835	COG1132	(ABC) transporter
HWN34_RS01840	COG1132	(ABC) transporter
HWN34_RS01855	COG1946	Acyl-CoA thioesterase
HWN34_RS01870	COG2018	Roadblock/LC7 domain
HWN34_RS01915	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HWN34_RS01950	COG2124	cytochrome p450
HWN34_RS01955	COG2130	NADP-dependent
HWN34_RS01960	COG1233	COG1233 Phytoene dehydrogenase and related
HWN34_RS01970	COG3321	synthase
HWN34_RS01970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWN34_RS02030	COG0477	Major facilitator Superfamily
HWN34_RS02035	COG0183	Belongs to the thiolase family
HWN34_RS02040	COG0583	DNA-binding transcription factor activity
HWN34_RS02045	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HWN34_RS02050	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HWN34_RS02055	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWN34_RS02060	COG1960	acyl-CoA dehydrogenase activity
HWN34_RS02065	COG2391	methyltransferase activity
HWN34_RS02110	COG0740	serine-type endopeptidase activity
HWN34_RS02115	COG0740	serine-type endopeptidase activity
HWN34_RS02135	COG3547	Transposase (IS116 IS110 IS902 family)
HWN34_RS02155	COG4521	taurine ABC transporter
HWN34_RS02160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWN34_RS02180	COG3959	Transketolase, thiamine diphosphate binding domain
HWN34_RS02185	COG3958	Transketolase
HWN34_RS02255	COG2755	lipolytic protein G-D-S-L family
HWN34_RS02290	COG1657	PFAM Prenyltransferase squalene oxidase
HWN34_RS02300	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HWN34_RS02310	COG1562	ergosterol biosynthetic process
HWN34_RS02315	COG1134	teichoic acid transport
HWN34_RS02315	COG1388	LysM domain
HWN34_RS02340	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HWN34_RS02355	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HWN34_RS02370	COG1024	Enoyl-CoA hydratase
HWN34_RS02385	COG2183	response to ionizing radiation
HWN34_RS02400	COG1802	Transcriptional regulator
HWN34_RS02405	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HWN34_RS02410	COG0402	S-adenosylhomocysteine deaminase activity
HWN34_RS02415	COG2226	methyltransferase
HWN34_RS02435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HWN34_RS02440	COG0789	Transcriptional regulator
HWN34_RS02445	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWN34_RS02445	COG1024	Enoyl-CoA hydratase
HWN34_RS02450	COG0183	Belongs to the thiolase family
HWN34_RS02460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HWN34_RS02470	COG1515	deoxyribonuclease V activity
HWN34_RS02500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWN34_RS02510	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HWN34_RS02510	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HWN34_RS02520	COG0488	(ABC) transporter
HWN34_RS02575	COG0254	rRNA binding
HWN34_RS02605	COG0789	Transcriptional regulator
HWN34_RS02645	COG2274	protein secretion by the type I secretion system
HWN34_RS02650	COG1846	Transcriptional regulator
HWN34_RS02710	COG1012	belongs to the aldehyde dehydrogenase family
HWN34_RS02730	COG2814	Major facilitator Superfamily
HWN34_RS02735	COG2259	Doxx family
HWN34_RS02745	COG1869	D-ribose catabolic process
HWN34_RS02750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWN34_RS02755	COG1172	Belongs to the binding-protein-dependent transport system permease family
HWN34_RS02760	COG1129	ABC transporter
HWN34_RS02765	COG1609	Transcriptional regulator
HWN34_RS02785	COG1295	ribonuclease BN
HWN34_RS02850	COG0673	inositol 2-dehydrogenase activity
HWN34_RS02855	COG1879	ABC-type sugar transport system periplasmic component
HWN34_RS02860	COG1172	Belongs to the binding-protein-dependent transport system permease family
HWN34_RS02865	COG1129	ABC transporter
HWN34_RS02870	COG1940	carbohydrate kinase activity
HWN34_RS02875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HWN34_RS02890	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HWN34_RS02900	COG0583	DNA-binding transcription factor activity
HWN34_RS02905	COG1115	amino acid carrier protein
HWN34_RS02920	COG2826	transposase and inactivated derivatives, IS30 family
HWN34_RS02935	COG2154	pterin-4-alpha-carbinolamine dehydratase
HWN34_RS02965	COG1140	nitrate reductase beta subunit
HWN34_RS03025	COG0693	protein deglycase activity
HWN34_RS03035	COG1597	lipid kinase activity
HWN34_RS03040	COG4106	trans-aconitate 2-methyltransferase activity
HWN34_RS03055	COG3226	Transcriptional regulator
HWN34_RS03080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWN34_RS03105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HWN34_RS03150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWN34_RS03155	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWN34_RS03160	COG1120	ATPase activity
HWN34_RS03165	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWN34_RS03175	COG0604	alcohol dehydrogenase
HWN34_RS03180	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HWN34_RS03180	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HWN34_RS03185	COG2301	Belongs to the HpcH HpaI aldolase family
HWN34_RS03200	COG0688	phosphatidylethanolamine metabolic process
HWN34_RS03210	COG1929	Belongs to the glycerate kinase type-1 family
HWN34_RS03215	COG0488	(ABC) transporter
HWN34_RS03230	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HWN34_RS03235	COG0702	epimerase
HWN34_RS03240	COG1028	Short-chain dehydrogenase reductase Sdr
HWN34_RS03250	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HWN34_RS03275	COG0159	tryptophan synthase activity
HWN34_RS03290	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HWN34_RS03305	COG0483	inositol monophosphate 1-phosphatase activity
HWN34_RS03315	COG0095	Lipoate-protein ligase
HWN34_RS03335	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HWN34_RS03360	COG0405	Gamma-glutamyltransferase
HWN34_RS03390	COG0765	amino acid transport
HWN34_RS03395	COG0765	amino acid transport
HWN34_RS03400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWN34_RS03405	COG1126	abc transporter atp-binding protein
HWN34_RS03440	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HWN34_RS03455	COG1960	acyl-CoA dehydrogenase activity
HWN34_RS03485	COG5183	chlorophyll binding
HWN34_RS03485	COG2133	pyrroloquinoline quinone binding
HWN34_RS03490	COG1132	(ABC) transporter
HWN34_RS03495	COG1132	(ABC) transporter
HWN34_RS03500	COG1120	ATPase activity
HWN34_RS03505	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWN34_RS03510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWN34_RS03515	COG2375	cellular response to nickel ion
HWN34_RS03520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HWN34_RS03525	COG2207	Transcriptional regulator
HWN34_RS03555	COG2197	response regulator
HWN34_RS03565	COG0464	growth
HWN34_RS03655	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HWN34_RS03665	COG1940	carbohydrate kinase activity
HWN34_RS03675	COG1172	Belongs to the binding-protein-dependent transport system permease family
HWN34_RS03685	COG2188	Transcriptional regulator
HWN34_RS03690	COG0673	inositol 2-dehydrogenase activity
HWN34_RS03705	COG2197	response regulator
HWN34_RS03710	COG4585	Histidine kinase
HWN34_RS03725	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HWN34_RS03730	COG1414	Transcriptional regulator
HWN34_RS03745	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HWN34_RS03750	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HWN34_RS03755	COG2080	2 iron, 2 sulfur cluster binding
HWN34_RS03775	COG4941	Belongs to the sigma-70 factor family
HWN34_RS03780	COG3795	YCII-related domain
HWN34_RS03785	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HWN34_RS03790	COG1621	beta-fructofuranosidase activity
HWN34_RS03810	COG1609	Transcriptional regulator
HWN34_RS03860	COG2233	PERMEase
HWN34_RS03875	COG2351	hydroxyisourate hydrolase activity
HWN34_RS03895	COG3622	Belongs to the hyi family
HWN34_RS03900	COG2084	Dehydrogenase
HWN34_RS03905	COG0753	catalase activity
HWN34_RS03910	COG3960	tartronate-semialdehyde synthase activity
HWN34_RS03920	COG0318	PFAM AMP-dependent synthetase and ligase
HWN34_RS03925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HWN34_RS03930	COG2197	response regulator
HWN34_RS03940	COG1309	transcriptional regulator
HWN34_RS03980	COG2252	PERMEase
HWN34_RS03985	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HWN34_RS04000	COG3835	regulator
HWN34_RS04005	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HWN34_RS04015	COG1802	Transcriptional regulator
HWN34_RS04030	COG1028	Short-chain dehydrogenase reductase Sdr
HWN34_RS04045	COG0028	Belongs to the TPP enzyme family
HWN34_RS04065	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HWN34_RS04070	COG1162	GTPase activity
HWN34_RS04080	COG2365	Tyrosine phosphatase family
HWN34_RS04120	COG1595	DNA-templated transcription, initiation
HWN34_RS04130	COG0789	Transcriptional regulator
HWN34_RS04140	COG0702	epimerase
HWN34_RS04145	COG1846	Transcriptional regulator
HWN34_RS04150	COG2409	Drug exporters of the RND superfamily
HWN34_RS04160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWN34_RS04165	COG1120	ATPase activity
HWN34_RS04175	COG2255	four-way junction helicase activity
HWN34_RS04200	COG2040	homocysteine
HWN34_RS04220	COG1960	acyl-CoA dehydrogenase activity
HWN34_RS04225	COG0604	alcohol dehydrogenase
HWN34_RS04250	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWN34_RS04260	COG0175	sulfate reduction
HWN34_RS04265	COG0529	Catalyzes the synthesis of activated sulfate
HWN34_RS04290	COG1116	anion transmembrane transporter activity
HWN34_RS04295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWN34_RS04310	COG0386	Belongs to the glutathione peroxidase family
HWN34_RS04345	COG2176	DNA-directed DNA polymerase activity
HWN34_RS04345	COG5002	protein histidine kinase activity
HWN34_RS04410	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HWN34_RS04415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HWN34_RS04435	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HWN34_RS04440	COG1595	DNA-templated transcription, initiation
HWN34_RS04455	COG0726	polysaccharide deacetylase
HWN34_RS04465	COG3220	belongs to the UPF0276 family
HWN34_RS04490	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWN34_RS04495	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HWN34_RS04515	COG0183	Belongs to the thiolase family
HWN34_RS04520	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWN34_RS04520	COG1024	Enoyl-CoA hydratase
HWN34_RS04540	COG0531	amino acid
HWN34_RS04545	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HWN34_RS04550	COG4214	carbohydrate transport
HWN34_RS04560	COG4213	ABC transporter substrate-binding protein
HWN34_RS04570	COG0395	ABC-type sugar transport system, permease component
HWN34_RS04575	COG1175	transmembrane transport
HWN34_RS04580	COG1653	transport
HWN34_RS04585	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HWN34_RS04610	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HWN34_RS04690	COG2235	arginine
HWN34_RS04695	COG1320	monovalent cation:proton antiporter activity
HWN34_RS04720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HWN34_RS04720	COG2111	Na H antiporter
HWN34_RS04730	COG2124	cytochrome p450
HWN34_RS04760	COG0531	amino acid
HWN34_RS04765	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HWN34_RS04770	COG2235	arginine
HWN34_RS04810	COG1799	cell septum assembly
HWN34_RS04820	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HWN34_RS04835	COG1556	Lactate utilization protein
HWN34_RS04840	COG1139	Iron-sulfur cluster binding protein
HWN34_RS04845	COG0247	lactate metabolic process
HWN34_RS04850	COG1620	l-lactate permease
HWN34_RS04860	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HWN34_RS04900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HWN34_RS04910	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HWN34_RS04925	COG1120	ATPase activity
HWN34_RS04930	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWN34_RS04935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWN34_RS04945	COG1733	regulation of RNA biosynthetic process
HWN34_RS04965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HWN34_RS04970	COG0601	transmembrane transport
HWN34_RS04980	COG0747	negative chemotaxis
HWN34_RS04990	COG1309	transcriptional regulator
HWN34_RS05005	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HWN34_RS05020	COG2936	dipeptidyl-peptidase activity
HWN34_RS05040	COG3540	Alkaline phosphatase
HWN34_RS05050	COG2050	protein possibly involved in aromatic compounds catabolism
HWN34_RS05065	COG0789	Transcriptional regulator
HWN34_RS05070	COG0640	Transcriptional regulator
HWN34_RS05090	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HWN34_RS05135	COG3226	Transcriptional regulator
HWN34_RS05140	COG0738	Major facilitator superfamily
HWN34_RS05155	COG4213	ABC transporter substrate-binding protein
HWN34_RS05160	COG1172	Belongs to the binding-protein-dependent transport system permease family
HWN34_RS05165	COG1172	Belongs to the binding-protein-dependent transport system permease family
HWN34_RS05170	COG1129	ABC transporter
HWN34_RS05175	COG1940	carbohydrate kinase activity
HWN34_RS05175	COG1846	Transcriptional regulator
HWN34_RS05180	COG0252	asparaginase activity
HWN34_RS05190	COG1028	Short-chain dehydrogenase reductase Sdr
HWN34_RS05210	COG1028	Short-chain dehydrogenase reductase Sdr
HWN34_RS05225	COG1028	Short-chain dehydrogenase reductase Sdr
HWN34_RS05255	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HWN34_RS05265	COG0473	3-isopropylmalate dehydrogenase activity
HWN34_RS05280	COG0656	L-ascorbic acid biosynthetic process
HWN34_RS05315	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HWN34_RS05340	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HWN34_RS05385	COG0583	DNA-binding transcription factor activity
HWN34_RS05395	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HWN34_RS05410	COG4221	oxidoreductase activity
HWN34_RS05415	COG0300	oxidoreductase activity
HWN34_RS05470	COG2233	PERMEase
HWN34_RS05475	COG0402	S-adenosylhomocysteine deaminase activity
HWN34_RS05490	COG0559	Belongs to the binding-protein-dependent transport system permease family
HWN34_RS05525	COG0395	ABC-type sugar transport system, permease component
HWN34_RS05530	COG1063	alcohol dehydrogenase
HWN34_RS05545	COG0438	transferase activity, transferring glycosyl groups
HWN34_RS05550	COG2197	response regulator
HWN34_RS05560	COG1136	(ABC) transporter
HWN34_RS05570	COG2197	response regulator
HWN34_RS05580	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HWN34_RS05590	COG3251	PFAM MbtH domain protein
HWN34_RS05600	COG2175	clavaminate synthase activity
HWN34_RS05645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HWN34_RS05650	COG0531	amino acid
HWN34_RS05655	COG0569	domain protein
HWN34_RS05685	COG1136	(ABC) transporter
HWN34_RS05705	COG0756	dUTP diphosphatase activity
HWN34_RS05730	COG2205	protein histidine kinase activity
HWN34_RS05735	COG0745	RESPONSE REGULATOR receiver
HWN34_RS05745	COG0483	inositol monophosphate 1-phosphatase activity
HWN34_RS05800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWN34_RS05805	COG1802	Transcriptional regulator
HWN34_RS05820	COG0612	Peptidase, M16
HWN34_RS05825	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HWN34_RS05835	COG0366	Alpha amylase catalytic
HWN34_RS05840	COG0395	ABC-type sugar transport system, permease component
HWN34_RS05845	COG1175	transmembrane transport
HWN34_RS05850	COG1653	transport
HWN34_RS05865	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWN34_RS05900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HWN34_RS05905	COG1802	Transcriptional regulator
HWN34_RS05940	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HWN34_RS05955	COG0588	phosphoglycerate mutase activity
HWN34_RS05975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HWN34_RS05980	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HWN34_RS06025	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HWN34_RS06035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HWN34_RS06040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HWN34_RS06050	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HWN34_RS06070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HWN34_RS06080	COG2205	protein histidine kinase activity
HWN34_RS06085	COG0745	RESPONSE REGULATOR receiver
HWN34_RS06090	COG1126	abc transporter atp-binding protein
HWN34_RS06095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWN34_RS06100	COG0765	amino acid transport
HWN34_RS06105	COG0765	amino acid transport
HWN34_RS06110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWN34_RS06125	COG2137	regulation of response to DNA damage stimulus
HWN34_RS06130	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HWN34_RS06155	COG0628	permease
HWN34_RS06180	COG1201	RNA secondary structure unwinding
HWN34_RS06185	COG0596	Alpha beta hydrolase
HWN34_RS06205	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HWN34_RS06215	COG0783	Belongs to the Dps family
HWN34_RS06220	COG1396	sequence-specific DNA binding
HWN34_RS06225	COG1546	Belongs to the CinA family
HWN34_RS06225	COG1058	Belongs to the CinA family
HWN34_RS06235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HWN34_RS06245	COG1674	ftsk spoiiie
HWN34_RS06255	COG4999	Histidine kinase
HWN34_RS06255	COG3850	Histidine kinase
HWN34_RS06255	COG3437	response regulator, receiver
HWN34_RS06255	COG2205	protein histidine kinase activity
HWN34_RS06260	COG2770	Histidine kinase
HWN34_RS06260	COG2208	phosphoserine phosphatase activity
HWN34_RS06290	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HWN34_RS06295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWN34_RS06300	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HWN34_RS06320	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HWN34_RS06325	COG0612	Peptidase, M16
HWN34_RS06330	COG1185	polyribonucleotide nucleotidyltransferase activity
HWN34_RS06335	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HWN34_RS06345	COG0455	bacterial-type flagellum organization
HWN34_RS06350	COG0747	negative chemotaxis
HWN34_RS06355	COG0601	transmembrane transport
HWN34_RS06360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HWN34_RS06365	COG0444	Belongs to the ABC transporter superfamily
HWN34_RS06370	COG4608	Belongs to the ABC transporter superfamily
HWN34_RS06375	COG1357	PFAM Pentapeptide repeats (8 copies)
HWN34_RS06390	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HWN34_RS06395	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HWN34_RS06405	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HWN34_RS06420	COG0779	Required for maturation of 30S ribosomal subunits
HWN34_RS06440	COG0442	prolyl-tRNA aminoacylation
HWN34_RS06465	COG0601	transmembrane transport
HWN34_RS06470	COG0747	negative chemotaxis
HWN34_RS06485	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HWN34_RS06490	COG0750	zinc metalloprotease
HWN34_RS06495	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HWN34_RS06500	COG1940	carbohydrate kinase activity
HWN34_RS06505	COG1012	belongs to the aldehyde dehydrogenase family
HWN34_RS06510	COG2508	Transcriptional regulator
HWN34_RS06540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWN34_RS06545	COG1177	transmembrane transport
HWN34_RS06550	COG1176	ABC-type spermidine putrescine transport system, permease component I
HWN34_RS06555	COG3842	ATPase activity
HWN34_RS06565	COG1012	belongs to the aldehyde dehydrogenase family
HWN34_RS06580	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HWN34_RS06585	COG0584	glycerophosphoryl diester phosphodiesterase
HWN34_RS06595	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HWN34_RS06600	COG1012	belongs to the aldehyde dehydrogenase family
HWN34_RS06610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HWN34_RS06635	COG3842	ATPase activity
HWN34_RS06640	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HWN34_RS06650	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HWN34_RS06655	COG0575	Belongs to the CDS family
HWN34_RS06660	COG0233	cytoplasmic translational termination
HWN34_RS06665	COG0528	UMP kinase activity
HWN34_RS06670	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HWN34_RS06675	COG0052	Belongs to the universal ribosomal protein uS2 family
HWN34_RS06680	COG4942	peptidase
HWN34_RS06680	COG1388	LysM domain
HWN34_RS06690	COG1191	sigma factor activity
HWN34_RS06705	COG0792	nuclease activity
HWN34_RS06720	COG0681	Belongs to the peptidase S26 family
HWN34_RS06725	COG0681	Belongs to the peptidase S26 family
HWN34_RS06730	COG0681	Belongs to the peptidase S26 family
HWN34_RS06740	COG0335	large ribosomal subunit rRNA binding
HWN34_RS06745	COG0336	Belongs to the RNA methyltransferase TrmD family
HWN34_RS06750	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HWN34_RS06755	COG1837	Belongs to the UPF0109 family
HWN34_RS06760	COG0228	four-way junction DNA binding
HWN34_RS06775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HWN34_RS06780	COG3547	Transposase (IS116 IS110 IS902 family)
HWN34_RS06790	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HWN34_RS06820	COG0477	Major facilitator Superfamily
HWN34_RS06825	COG1196	nuclear chromosome segregation
HWN34_RS06835	COG1254	Belongs to the acylphosphatase family
HWN34_RS06840	COG2340	Cysteine-rich secretory protein family
HWN34_RS06845	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HWN34_RS06850	COG0571	ribonuclease III activity
HWN34_RS06855	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HWN34_RS06870	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HWN34_RS06875	COG0742	ribosomal rna small subunit methyltransferase
HWN34_RS06885	COG1461	Dihydroxyacetone kinase
HWN34_RS06890	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HWN34_RS06895	COG0351	phosphomethylpyrimidine kinase
HWN34_RS06915	COG1181	Belongs to the D-alanine--D-alanine ligase family
HWN34_RS06920	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HWN34_RS06930	COG1920	GTP binding
HWN34_RS06940	COG0776	regulation of translation
HWN34_RS06950	COG0066	3-isopropylmalate dehydratase activity
HWN34_RS06955	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HWN34_RS06960	COG1414	Transcriptional regulator
HWN34_RS07005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HWN34_RS07010	COG0179	Fumarylacetoacetate (FAA) hydrolase
HWN34_RS07025	COG2018	Roadblock/LC7 domain
HWN34_RS07045	COG2018	Roadblock/LC7 domain
HWN34_RS07065	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HWN34_RS07075	COG2353	YceI-like domain
HWN34_RS07115	COG0789	Transcriptional regulator
HWN34_RS07135	COG4221	oxidoreductase activity
HWN34_RS07170	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HWN34_RS07175	COG0477	Major facilitator Superfamily
HWN34_RS07180	COG2957	Belongs to the agmatine deiminase family
HWN34_RS07185	COG0804	urea catabolic process
HWN34_RS07190	COG0832	Belongs to the urease beta subunit family
HWN34_RS07190	COG0831	urea catabolic process
HWN34_RS07195	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HWN34_RS07200	COG0473	3-isopropylmalate dehydrogenase activity
HWN34_RS07210	COG0575	Belongs to the CDS family
HWN34_RS07225	COG1012	belongs to the aldehyde dehydrogenase family
HWN34_RS07230	COG0506	proline dehydrogenase activity
HWN34_RS07235	COG3835	regulator
HWN34_RS07255	COG2890	protein-(glutamine-N5) methyltransferase activity
HWN34_RS07265	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HWN34_RS07270	COG0440	acetolactate synthase activity
HWN34_RS07290	COG0667	Aldo Keto reductase
HWN34_RS07295	COG2133	pyrroloquinoline quinone binding
HWN34_RS07310	COG3547	Transposase (IS116 IS110 IS902 family)
HWN34_RS07315	COG3547	Transposase (IS116 IS110 IS902 family)
HWN34_RS07340	COG2409	Drug exporters of the RND superfamily
HWN34_RS07345	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HWN34_RS07355	COG0154	amidase activity
HWN34_RS07360	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HWN34_RS07370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HWN34_RS07380	COG4221	oxidoreductase activity
HWN34_RS07400	COG0482	sulfurtransferase activity
HWN34_RS07425	COG2860	membrane
HWN34_RS07430	COG4608	Belongs to the ABC transporter superfamily
HWN34_RS07435	COG0444	Belongs to the ABC transporter superfamily
HWN34_RS07450	COG0747	negative chemotaxis
HWN34_RS07470	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HWN34_RS07475	COG0509	glycine decarboxylation via glycine cleavage system
HWN34_RS07480	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HWN34_RS07485	COG1760	l-serine dehydratase
HWN34_RS07500	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HWN34_RS07505	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HWN34_RS07510	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HWN34_RS07525	COG0477	Major facilitator Superfamily
HWN34_RS07540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HWN34_RS07565	COG2085	NADP oxidoreductase coenzyme F420-dependent
HWN34_RS07590	COG1376	ErfK ybiS ycfS ynhG family protein
HWN34_RS07615	COG1132	(ABC) transporter
HWN34_RS07620	COG1132	(ABC) transporter
HWN34_RS07630	COG1733	regulation of RNA biosynthetic process
HWN34_RS07650	COG0366	Alpha amylase catalytic
HWN34_RS07655	COG0366	Alpha amylase catalytic
HWN34_RS07660	COG3281	Trehalose synthase
HWN34_RS07665	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HWN34_RS07680	COG1119	ATPase activity
HWN34_RS07685	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HWN34_RS07700	COG1301	dicarboxylic acid transport
HWN34_RS07705	COG3290	protein histidine kinase activity
HWN34_RS07710	COG4565	transcriptional regulatory protein
HWN34_RS07715	COG0205	6-phosphofructokinase activity
HWN34_RS07720	COG0280	phosphate acetyltransferase
HWN34_RS07720	COG0857	belongs to the CobB CobQ family
HWN34_RS07725	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HWN34_RS07765	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HWN34_RS07765	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HWN34_RS07840	COG1335	isochorismatase
HWN34_RS07870	COG0183	Belongs to the thiolase family
HWN34_RS07890	COG1131	(ABC) transporter
HWN34_RS07925	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HWN34_RS07940	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWN34_RS07955	COG4585	Histidine kinase
HWN34_RS07960	COG2197	response regulator
HWN34_RS07980	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HWN34_RS07985	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HWN34_RS07990	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HWN34_RS07995	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HWN34_RS08000	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HWN34_RS08005	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HWN34_RS08010	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HWN34_RS08025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HWN34_RS08030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HWN34_RS08040	COG2890	protein-(glutamine-N5) methyltransferase activity
HWN34_RS08045	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HWN34_RS08050	COG0254	rRNA binding
HWN34_RS08055	COG1316	TRANSCRIPTIONal
HWN34_RS08065	COG0083	homoserine kinase activity
HWN34_RS08070	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HWN34_RS08075	COG0460	homoserine dehydrogenase
HWN34_RS08080	COG0019	diaminopimelate decarboxylase activity
HWN34_RS08085	COG0018	arginyl-trna synthetase
HWN34_RS08110	COG1012	belongs to the aldehyde dehydrogenase family
HWN34_RS08120	COG1191	sigma factor activity
HWN34_RS08125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HWN34_RS08125	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HWN34_RS08135	COG2267	carboxylic ester hydrolase activity
HWN34_RS08140	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HWN34_RS08155	COG0772	Belongs to the SEDS family
HWN34_RS08230	COG0726	polysaccharide deacetylase
HWN34_RS08235	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HWN34_RS08240	COG0477	Major facilitator Superfamily
HWN34_RS08255	COG1595	DNA-templated transcription, initiation
HWN34_RS08265	COG1131	(ABC) transporter
HWN34_RS08285	COG0745	RESPONSE REGULATOR receiver
HWN34_RS08290	COG2205	protein histidine kinase activity
HWN34_RS08295	COG0567	Dehydrogenase, E1 component
HWN34_RS08295	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWN34_RS08325	COG2255	four-way junction helicase activity
HWN34_RS08365	COG0604	alcohol dehydrogenase
HWN34_RS08370	COG0281	malic enzyme
HWN34_RS08385	COG1126	abc transporter atp-binding protein
HWN34_RS08390	COG4106	trans-aconitate 2-methyltransferase activity
HWN34_RS08450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HWN34_RS08455	COG1959	2 iron, 2 sulfur cluster binding
HWN34_RS08475	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HWN34_RS08490	COG2172	sigma factor antagonist activity
HWN34_RS08505	COG1597	lipid kinase activity
HWN34_RS08525	COG0363	glucosamine-6-phosphate deaminase activity
HWN34_RS08530	COG1472	Belongs to the glycosyl hydrolase 3 family
HWN34_RS08535	COG0395	ABC-type sugar transport system, permease component
HWN34_RS08540	COG1175	transmembrane transport
HWN34_RS08545	COG2182	Extracellular solute-binding protein
HWN34_RS08550	COG2188	Transcriptional regulator
HWN34_RS08555	COG1966	Carbon starvation protein
HWN34_RS08575	COG2124	cytochrome p450
HWN34_RS08585	COG0242	peptide deformylase activity
HWN34_RS08595	COG5662	AntiSigma factor
HWN34_RS08600	COG1595	DNA-templated transcription, initiation
HWN34_RS08610	COG2135	peptidase activity
HWN34_RS08620	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HWN34_RS08630	COG2076	Multidrug Resistance protein
HWN34_RS08640	COG0483	inositol monophosphate 1-phosphatase activity
HWN34_RS08645	COG0753	catalase activity
HWN34_RS08670	COG1615	UPF0182 protein
HWN34_RS08680	COG3480	Lon protease (S16) C-terminal proteolytic domain
HWN34_RS08735	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HWN34_RS08740	COG3547	Transposase (IS116 IS110 IS902 family)
HWN34_RS08775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HWN34_RS08780	COG0210	DNA helicase
HWN34_RS08870	COG0513	Belongs to the DEAD box helicase family
HWN34_RS08880	COG1432	Conserved Protein
HWN34_RS08890	COG2095	MarC family integral membrane protein
HWN34_RS08895	COG0613	PHP domain protein
HWN34_RS08900	COG2814	Major facilitator Superfamily
HWN34_RS08910	COG0598	Magnesium transport protein CorA
HWN34_RS08950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HWN34_RS08955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWN34_RS08965	COG1595	DNA-templated transcription, initiation
HWN34_RS08980	COG1024	Enoyl-CoA hydratase
HWN34_RS08990	COG0519	Catalyzes the synthesis of GMP from XMP
HWN34_RS09025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HWN34_RS09055	COG0456	acetyltransferase
HWN34_RS09060	COG2912	Transglutaminase-like superfamily
HWN34_RS09070	COG1609	Transcriptional regulator
HWN34_RS09075	COG1172	Belongs to the binding-protein-dependent transport system permease family
HWN34_RS09085	COG1129	ABC transporter
HWN34_RS09090	COG1879	ABC-type sugar transport system periplasmic component
HWN34_RS09095	COG3250	beta-galactosidase activity
HWN34_RS09115	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HWN34_RS09140	COG4608	Belongs to the ABC transporter superfamily
HWN34_RS09150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HWN34_RS09155	COG0601	transmembrane transport
HWN34_RS09165	COG4608	Belongs to the ABC transporter superfamily
HWN34_RS09170	COG0444	Belongs to the ABC transporter superfamily
HWN34_RS09175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HWN34_RS09180	COG0601	transmembrane transport
HWN34_RS09250	COG1554	hydrolase, family 65, central catalytic
HWN34_RS09310	COG1028	Short-chain dehydrogenase reductase Sdr
HWN34_RS09315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWN34_RS09325	COG3473	Maleate cis-trans isomerase
HWN34_RS09345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWN34_RS09350	COG0765	amino acid transport
HWN34_RS09355	COG0765	amino acid transport
HWN34_RS09360	COG1126	abc transporter atp-binding protein
HWN34_RS09390	COG3397	chitin binding
HWN34_RS09445	COG0673	inositol 2-dehydrogenase activity
HWN34_RS09450	COG0179	Fumarylacetoacetate (FAA) hydrolase
HWN34_RS09455	COG0706	membrane insertase activity
HWN34_RS09500	COG2271	Major facilitator Superfamily
HWN34_RS09510	COG2733	membrane
HWN34_RS09540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HWN34_RS09550	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HWN34_RS09575	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HWN34_RS09585	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HWN34_RS09590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWN34_RS09595	COG1263	PTS System
HWN34_RS09605	COG1234	tRNA 3'-trailer cleavage
HWN34_RS09630	COG1113	amino acid transport
HWN34_RS09645	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HWN34_RS09655	COG1335	isochorismatase
HWN34_RS09685	COG0277	FAD linked oxidase domain protein
HWN34_RS09695	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HWN34_RS09705	COG1174	glycine betaine transport
HWN34_RS09710	COG0517	IMP dehydrogenase activity
HWN34_RS09710	COG1125	glycine betaine transport
HWN34_RS09715	COG1174	glycine betaine transport
HWN34_RS09760	COG1116	anion transmembrane transporter activity
HWN34_RS09775	COG2318	DinB family
HWN34_RS09810	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HWN34_RS09835	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HWN34_RS09850	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HWN34_RS09855	COG0395	ABC-type sugar transport system, permease component
HWN34_RS09860	COG1175	transmembrane transport
HWN34_RS09875	COG1678	Uncharacterized ACR, COG1678
HWN34_RS09880	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HWN34_RS09885	COG0776	regulation of translation
HWN34_RS09895	COG3973	AAA domain
HWN34_RS09895	COG3973	AAA domain
HWN34_RS09940	COG0583	DNA-binding transcription factor activity
HWN34_RS09955	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HWN34_RS09960	COG0793	Belongs to the peptidase S41A family
HWN34_RS09970	COG2884	Cell division ATP-binding protein ftsE
HWN34_RS09985	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HWN34_RS09990	COG0515	serine threonine protein kinase
HWN34_RS09995	COG0515	serine threonine protein kinase
HWN34_RS10020	COG1716	ATPase activity
HWN34_RS10025	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HWN34_RS10040	COG0395	ABC-type sugar transport system, permease component
HWN34_RS10045	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HWN34_RS10050	COG0438	transferase activity, transferring glycosyl groups
HWN34_RS10055	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HWN34_RS10060	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HWN34_RS10070	COG2226	methyltransferase
HWN34_RS10085	COG2902	Dehydrogenase
HWN34_RS10105	COG0583	DNA-binding transcription factor activity
HWN34_RS10125	COG0653	protein targeting
HWN34_RS10130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWN34_RS10135	COG3214	Protein conserved in bacteria
HWN34_RS10140	COG2197	response regulator
HWN34_RS10145	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HWN34_RS10155	COG0823	Involved in the tonB-independent uptake of proteins
HWN34_RS10160	COG5002	protein histidine kinase activity
HWN34_RS10165	COG0745	RESPONSE REGULATOR receiver
HWN34_RS10170	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HWN34_RS10190	COG0714	Associated with various cellular activities
HWN34_RS10195	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HWN34_RS10230	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HWN34_RS10240	COG1482	cell wall glycoprotein biosynthetic process
HWN34_RS10250	COG2835	tetraacyldisaccharide 4'-kinase activity
HWN34_RS10260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HWN34_RS10270	COG1620	l-lactate permease
HWN34_RS10305	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HWN34_RS10310	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HWN34_RS10310	COG0778	Nitroreductase
HWN34_RS10340	COG1316	TRANSCRIPTIONal
HWN34_RS10360	COG1316	TRANSCRIPTIONal
HWN34_RS10365	COG3046	protein related to deoxyribodipyrimidine photolyase
HWN34_RS10415	COG0753	catalase activity
HWN34_RS10445	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HWN34_RS10455	COG2072	flavoprotein involved in K transport
HWN34_RS10480	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HWN34_RS10495	COG2205	protein histidine kinase activity
HWN34_RS10500	COG0745	RESPONSE REGULATOR receiver
HWN34_RS10505	COG3104	oligopeptide transport
HWN34_RS10515	COG1366	Belongs to the anti-sigma-factor antagonist family
HWN34_RS10520	COG1191	sigma factor activity
HWN34_RS10525	COG1228	amidohydrolase
HWN34_RS10535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HWN34_RS10555	COG0395	ABC-type sugar transport system, permease component
HWN34_RS10615	COG2755	lipolytic protein G-D-S-L family
HWN34_RS10620	COG0183	Belongs to the thiolase family
HWN34_RS10640	COG1476	TRANSCRIPTIONal
HWN34_RS10655	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HWN34_RS10665	COG1136	(ABC) transporter
HWN34_RS10670	COG1136	(ABC) transporter
HWN34_RS10670	COG0577	efflux transmembrane transporter activity
HWN34_RS10675	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HWN34_RS10680	COG1252	NADH dehydrogenase
HWN34_RS10710	COG0148	phosphopyruvate hydratase activity
HWN34_RS10765	COG1733	regulation of RNA biosynthetic process
HWN34_RS10805	COG0154	amidase activity
HWN34_RS10810	COG3226	Transcriptional regulator
HWN34_RS10820	COG1473	amidohydrolase
HWN34_RS10875	COG3629	intracellular signal transduction
HWN34_RS10875	COG3903	Transcriptional regulator
HWN34_RS10885	COG0477	Major facilitator Superfamily
HWN34_RS10925	COG0596	Alpha beta hydrolase
HWN34_RS10935	COG1316	TRANSCRIPTIONal
HWN34_RS10955	COG0789	Transcriptional regulator
HWN34_RS10980	COG4585	Histidine kinase
HWN34_RS10990	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HWN34_RS10995	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HWN34_RS11020	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HWN34_RS11025	COG0193	aminoacyl-tRNA hydrolase activity
HWN34_RS11035	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HWN34_RS11055	COG4106	trans-aconitate 2-methyltransferase activity
HWN34_RS11065	COG2197	response regulator
HWN34_RS11070	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HWN34_RS11115	COG0488	(ABC) transporter
HWN34_RS11120	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HWN34_RS11125	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HWN34_RS11130	COG0084	hydrolase, TatD family'
HWN34_RS11215	COG2409	Drug exporters of the RND superfamily
HWN34_RS11225	COG0793	Belongs to the peptidase S41A family
HWN34_RS11225	COG4946	Tricorn protease homolog
HWN34_RS11235	COG4221	oxidoreductase activity
HWN34_RS11245	COG2072	flavoprotein involved in K transport
HWN34_RS11260	COG0708	Exodeoxyribonuclease III
HWN34_RS11270	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HWN34_RS11290	COG2197	response regulator
HWN34_RS11330	COG0315	cyclic pyranopterin monophosphate synthase activity
HWN34_RS11330	COG0521	Mo-molybdopterin cofactor biosynthetic process
HWN34_RS11335	COG0315	cyclic pyranopterin monophosphate synthase activity
HWN34_RS11345	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HWN34_RS11350	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HWN34_RS11360	COG3263	regulation of cellular component size
HWN34_RS11375	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HWN34_RS11385	COG1970	mechanosensitive ion channel activity
HWN34_RS11400	COG3191	aminopeptidase activity
HWN34_RS11420	COG3384	dioxygenase
HWN34_RS11425	COG1846	Transcriptional regulator
HWN34_RS11480	COG2050	protein possibly involved in aromatic compounds catabolism
HWN34_RS11490	COG0183	Belongs to the thiolase family
HWN34_RS11495	COG1024	Enoyl-CoA hydratase
HWN34_RS11500	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWN34_RS11505	COG3396	Phenylacetate-CoA oxygenase
HWN34_RS11510	COG3460	Phenylacetate-CoA oxygenase
HWN34_RS11515	COG3396	Phenylacetate-CoA oxygenase
HWN34_RS11520	COG2151	metal-sulfur cluster biosynthetic enzyme
HWN34_RS11525	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HWN34_RS11560	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HWN34_RS11585	COG1278	Cold shock
HWN34_RS11665	COG5297	Belongs to the glycosyl hydrolase family 6
HWN34_RS11685	COG0148	phosphopyruvate hydratase activity
HWN34_RS11700	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HWN34_RS11740	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HWN34_RS11780	COG0515	serine threonine protein kinase
HWN34_RS11780	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HWN34_RS11785	COG1309	transcriptional regulator
HWN34_RS11805	COG2072	flavoprotein involved in K transport
HWN34_RS11810	COG2271	Major facilitator Superfamily
HWN34_RS11830	COG1366	Belongs to the anti-sigma-factor antagonist family
HWN34_RS11910	COG4821	SIS domain
HWN34_RS11920	COG0259	pyridoxamine-phosphate oxidase activity
HWN34_RS11940	COG1024	Enoyl-CoA hydratase
HWN34_RS11955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HWN34_RS11990	COG0583	DNA-binding transcription factor activity
HWN34_RS12000	COG0277	FAD linked oxidase domain protein
HWN34_RS12000	COG0247	lactate metabolic process
HWN34_RS12005	COG2205	protein histidine kinase activity
HWN34_RS12025	COG2124	cytochrome p450
HWN34_RS12035	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HWN34_RS12135	COG0667	Aldo Keto reductase
HWN34_RS12160	COG2252	PERMEase
HWN34_RS12170	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HWN34_RS12200	COG2814	Major facilitator Superfamily
HWN34_RS12210	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HWN34_RS12215	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HWN34_RS12220	COG1278	Cold shock
HWN34_RS12230	COG2197	response regulator
HWN34_RS12235	COG1132	(ABC) transporter
HWN34_RS12240	COG1132	(ABC) transporter
HWN34_RS12250	COG0515	serine threonine protein kinase
HWN34_RS12255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HWN34_RS12260	COG1120	ATPase activity
HWN34_RS12265	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWN34_RS12270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWN34_RS12280	COG1295	ribonuclease BN
HWN34_RS12290	COG2124	cytochrome p450
HWN34_RS12345	COG1061	Type III restriction enzyme res subunit
HWN34_RS12370	COG0667	Aldo Keto reductase
HWN34_RS12375	COG0789	Transcriptional regulator
HWN34_RS12400	COG3973	AAA domain
HWN34_RS12455	COG4585	Histidine kinase
HWN34_RS12460	COG2197	response regulator
HWN34_RS12480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWN34_RS12545	COG0406	alpha-ribazole phosphatase activity
HWN34_RS12555	COG1737	Transcriptional regulator
HWN34_RS12560	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HWN34_RS12565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWN34_RS12565	COG1263	PTS System
HWN34_RS12570	COG0667	Aldo Keto reductase
HWN34_RS12610	COG1278	Cold shock
HWN34_RS12625	COG0463	Glycosyl transferase, family 2
HWN34_RS12650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HWN34_RS12690	COG1105	Belongs to the carbohydrate kinase PfkB family
HWN34_RS12715	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HWN34_RS12745	COG1309	transcriptional regulator
HWN34_RS12760	COG1136	(ABC) transporter
HWN34_RS12760	COG0577	efflux transmembrane transporter activity
HWN34_RS12800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWN34_RS12855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HWN34_RS12935	COG1366	Belongs to the anti-sigma-factor antagonist family
HWN34_RS12940	COG1366	Belongs to the anti-sigma-factor antagonist family
HWN34_RS12945	COG2172	sigma factor antagonist activity
HWN34_RS12970	COG0577	efflux transmembrane transporter activity
HWN34_RS12970	COG1136	(ABC) transporter
HWN34_RS12975	COG0577	efflux transmembrane transporter activity
HWN34_RS13025	COG2409	Drug exporters of the RND superfamily
HWN34_RS13035	COG4585	Histidine kinase
HWN34_RS13040	COG2197	response regulator
HWN34_RS13045	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HWN34_RS13050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HWN34_RS13070	COG0301	tRNA thio-modification
HWN34_RS13090	COG0513	Belongs to the DEAD box helicase family
HWN34_RS13095	COG1278	Cold shock
HWN34_RS13125	COG2770	Histidine kinase
HWN34_RS13125	COG2208	phosphoserine phosphatase activity
HWN34_RS13160	COG0456	acetyltransferase
HWN34_RS13170	COG0436	Aminotransferase
HWN34_RS13180	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HWN34_RS13190	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HWN34_RS13195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWN34_RS13195	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HWN34_RS13200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWN34_RS13200	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWN34_RS13210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWN34_RS13210	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HWN34_RS13245	COG2814	Major facilitator Superfamily
HWN34_RS13255	COG3842	ATPase activity
HWN34_RS13265	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HWN34_RS13275	COG1253	flavin adenine dinucleotide binding
HWN34_RS13290	COG0215	cysteine-tRNA ligase activity
HWN34_RS13305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HWN34_RS13325	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HWN34_RS13330	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HWN34_RS13335	COG1329	Transcriptional regulator
HWN34_RS13345	COG0745	RESPONSE REGULATOR receiver
HWN34_RS13350	COG5002	protein histidine kinase activity
HWN34_RS13365	COG2076	Multidrug Resistance protein
HWN34_RS13390	COG3311	Transcriptional regulator
HWN34_RS13445	COG2264	protein methyltransferase activity
HWN34_RS13450	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HWN34_RS13485	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HWN34_RS13505	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HWN34_RS13510	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HWN34_RS13540	COG4942	peptidase
HWN34_RS13545	COG0783	Belongs to the Dps family
HWN34_RS13550	COG1120	ATPase activity
HWN34_RS13555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWN34_RS13575	COG5001	Diguanylate cyclase
HWN34_RS13590	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HWN34_RS13605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HWN34_RS13610	COG1316	TRANSCRIPTIONal
HWN34_RS13620	COG0640	Transcriptional regulator
HWN34_RS13630	COG1252	NADH dehydrogenase
HWN34_RS13685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWN34_RS13705	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HWN34_RS13715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HWN34_RS13740	COG2186	Transcriptional regulator
HWN34_RS13750	COG0318	PFAM AMP-dependent synthetase and ligase
HWN34_RS13755	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HWN34_RS13755	COG0825	malonyl-CoA metabolic process
HWN34_RS13765	COG0789	Transcriptional regulator
HWN34_RS13780	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HWN34_RS13785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HWN34_RS13800	COG0789	Transcriptional regulator
HWN34_RS13820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HWN34_RS13835	COG2197	response regulator
HWN34_RS13865	COG2249	NAD(P)H dehydrogenase (quinone) activity
HWN34_RS13880	COG0537	adenosine 5'-monophosphoramidase activity
HWN34_RS13920	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HWN34_RS13925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HWN34_RS13925	COG1754	DNA topoisomerase type I activity
HWN34_RS13935	COG2890	protein-(glutamine-N5) methyltransferase activity
HWN34_RS13950	COG1366	Belongs to the anti-sigma-factor antagonist family
HWN34_RS13955	COG1111	helicase
HWN34_RS13955	COG1205	dead DEAH box helicase
HWN34_RS14015	COG0659	secondary active sulfate transmembrane transporter activity
HWN34_RS14020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HWN34_RS14025	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HWN34_RS14035	COG2267	carboxylic ester hydrolase activity
HWN34_RS14060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWN34_RS14070	COG0251	oxidation-reduction process
HWN34_RS14085	COG0003	Pfam Anion-transporting ATPase
HWN34_RS14100	COG2826	transposase and inactivated derivatives, IS30 family
HWN34_RS14110	COG1408	metallophosphoesterase
HWN34_RS14125	COG0577	efflux transmembrane transporter activity
HWN34_RS14125	COG1136	(ABC) transporter
HWN34_RS14140	COG2318	DinB family
HWN34_RS14165	COG0596	Alpha beta hydrolase
HWN34_RS14225	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HWN34_RS14235	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HWN34_RS14240	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HWN34_RS14300	COG1733	regulation of RNA biosynthetic process
HWN34_RS14310	COG0666	response to abiotic stimulus
HWN34_RS14320	COG4585	Histidine kinase
HWN34_RS14325	COG2197	response regulator
HWN34_RS14380	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HWN34_RS14470	COG1470	cell adhesion involved in biofilm formation
HWN34_RS14470	COG0366	Alpha amylase catalytic
HWN34_RS14485	COG0579	oxidoreductase
HWN34_RS14490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HWN34_RS14500	COG0667	Aldo Keto reductase
HWN34_RS14530	COG0542	response to heat
HWN34_RS14560	COG0513	Belongs to the DEAD box helicase family
HWN34_RS14595	COG1643	Atp-dependent helicase
HWN34_RS14630	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HWN34_RS14645	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HWN34_RS14650	COG0047	phosphoribosylformylglycinamidine synthase activity
HWN34_RS14655	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HWN34_RS14690	COG2197	response regulator
HWN34_RS14700	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HWN34_RS14715	COG0151	Belongs to the GarS family
HWN34_RS14740	COG0659	secondary active sulfate transmembrane transporter activity
HWN34_RS14750	COG2837	iron assimilation
HWN34_RS14755	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HWN34_RS14825	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HWN34_RS14860	COG1191	sigma factor activity
HWN34_RS14865	COG1191	sigma factor activity
HWN34_RS14880	COG0477	Major facilitator Superfamily
HWN34_RS14900	COG0477	Major facilitator Superfamily
HWN34_RS14945	COG0318	PFAM AMP-dependent synthetase and ligase
HWN34_RS14950	COG1595	DNA-templated transcription, initiation
HWN34_RS14970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWN34_RS14985	COG0653	protein targeting
HWN34_RS15000	COG0006	proline dipeptidase activity
HWN34_RS15020	COG1999	signal sequence binding
HWN34_RS15035	COG2837	iron assimilation
HWN34_RS15040	COG0077	Prephenate dehydratase
HWN34_RS15045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HWN34_RS15050	COG0561	phosphatase activity
HWN34_RS15070	COG1131	(ABC) transporter
HWN34_RS15090	COG0561	phosphatase activity
HWN34_RS15095	COG1196	nuclear chromosome segregation
HWN34_RS15095	COG0741	lytic transglycosylase activity
HWN34_RS15095	COG0739	heme binding
HWN34_RS15105	COG4988	ABC transporter
HWN34_RS15110	COG1294	oxidase, subunit
HWN34_RS15115	COG1271	oxidase subunit
HWN34_RS15120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HWN34_RS15125	COG1609	Transcriptional regulator
HWN34_RS15140	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HWN34_RS15165	COG0662	Cupin 2, conserved barrel domain protein
HWN34_RS15170	COG1950	PFAM Membrane protein of
HWN34_RS15175	COG0626	cystathionine gamma-synthase activity
HWN34_RS15220	COG0110	maltose O-acetyltransferase activity
HWN34_RS15225	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HWN34_RS15230	COG0305	Participates in initiation and elongation during chromosome replication
HWN34_RS15240	COG0359	binds to the 23S rRNA
HWN34_RS15245	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HWN34_RS15250	COG0629	single-stranded DNA binding
HWN34_RS15255	COG0360	Binds together with S18 to 16S ribosomal RNA
HWN34_RS15280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HWN34_RS15305	COG0617	tRNA 3'-terminal CCA addition
HWN34_RS15320	COG2815	serine threonine protein kinase
HWN34_RS15320	COG0515	serine threonine protein kinase
HWN34_RS15325	COG1595	DNA-templated transcription, initiation
HWN34_RS15335	COG0492	ferredoxin-NADP+ reductase activity
HWN34_RS15340	COG3118	belongs to the thioredoxin family
HWN34_RS15355	COG1192	Involved in chromosome partitioning
HWN34_RS15360	COG0357	Ribosomal RNA small subunit methyltransferase G
HWN34_RS15370	COG0706	membrane insertase activity
HWN34_RS15375	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HWN34_RS15380	COG0594	ribonuclease P activity
HWN34_RS15385	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HWN34_RS15390	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HWN34_RS15395	COG0592	DNA-directed DNA polymerase activity
HWN34_RS15400	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HWN34_RS15405	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HWN34_RS15410	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HWN34_RS15415	COG0187	DNA topoisomerase II activity
HWN34_RS15420	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HWN34_RS15460	COG0515	serine threonine protein kinase
HWN34_RS15490	COG1278	Cold shock
HWN34_RS15495	COG1309	transcriptional regulator
HWN34_RS15515	COG0705	Rhomboid family
HWN34_RS15535	COG3764	Sortase (surface protein transpeptidase)
HWN34_RS15540	COG3764	Sortase (surface protein transpeptidase)
HWN34_RS15545	COG0515	serine threonine protein kinase
HWN34_RS15565	COG1716	ATPase activity
HWN34_RS15570	COG1716	ATPase activity
HWN34_RS15580	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HWN34_RS15585	COG1733	regulation of RNA biosynthetic process
HWN34_RS15625	COG1522	sequence-specific DNA binding
HWN34_RS15645	COG0746	molybdenum cofactor guanylyltransferase activity
HWN34_RS15650	COG0303	'Molybdopterin
HWN34_RS15655	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HWN34_RS15680	COG0515	serine threonine protein kinase
HWN34_RS15685	COG0515	serine threonine protein kinase
HWN34_RS15700	COG0022	dehydrogenase e1 component
HWN34_RS15705	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWN34_RS15760	COG1362	aminopeptidase activity
HWN34_RS15780	COG1960	acyl-CoA dehydrogenase activity
HWN34_RS15790	COG1741	Belongs to the pirin family
HWN34_RS15795	COG0628	permease
HWN34_RS15805	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HWN34_RS15815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWN34_RS15855	COG1316	TRANSCRIPTIONal
HWN34_RS15870	COG2268	Band 7 protein
HWN34_RS15875	COG1937	Protein conserved in bacteria
HWN34_RS15880	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HWN34_RS15885	COG2208	phosphoserine phosphatase activity
HWN34_RS15885	COG2770	Histidine kinase
HWN34_RS15915	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWN34_RS15935	COG0477	Major facilitator Superfamily
HWN34_RS15965	COG0494	nUDIX hydrolase
HWN34_RS15995	COG2181	nitrate reductase activity
HWN34_RS15995	COG0247	lactate metabolic process
HWN34_RS16000	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HWN34_RS16040	COG0717	Belongs to the dCTP deaminase family
HWN34_RS16065	COG2814	Major facilitator Superfamily
HWN34_RS16075	COG1695	Transcriptional regulator
HWN34_RS16105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWN34_RS16105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWN34_RS16140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWN34_RS16145	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWN34_RS16150	COG1120	ATPase activity
HWN34_RS16155	COG1404	Belongs to the peptidase S8 family
HWN34_RS16160	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HWN34_RS16190	COG1131	(ABC) transporter
HWN34_RS16195	COG1725	Transcriptional regulator
HWN34_RS16230	COG0443	Heat shock 70 kDa protein
HWN34_RS16235	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HWN34_RS16240	COG0484	heat shock protein binding
HWN34_RS16245	COG0789	Transcriptional regulator
HWN34_RS16270	COG0477	Major facilitator Superfamily
HWN34_RS16285	COG2378	regulation of single-species biofilm formation
HWN34_RS16330	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HWN34_RS16345	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HWN34_RS16350	COG0191	fructose-bisphosphate aldolase activity
HWN34_RS16355	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HWN34_RS16360	COG0477	Major facilitator Superfamily
HWN34_RS16380	COG3844	kynureninase activity
HWN34_RS16395	COG4585	Histidine kinase
HWN34_RS16400	COG2197	response regulator
HWN34_RS16410	COG1335	isochorismatase
HWN34_RS16425	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HWN34_RS16440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HWN34_RS16445	COG0798	PFAM Bile acid sodium symporter
HWN34_RS16465	COG2124	cytochrome p450
HWN34_RS16470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HWN34_RS16475	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HWN34_RS16480	COG0477	Major facilitator Superfamily
HWN34_RS16530	COG0509	glycine decarboxylation via glycine cleavage system
HWN34_RS16540	COG2318	DinB family
HWN34_RS16560	COG0739	heme binding
HWN34_RS16560	COG1196	nuclear chromosome segregation
HWN34_RS16560	COG0741	lytic transglycosylase activity
HWN34_RS16565	COG0671	phosphoesterase, PA-phosphatase related
HWN34_RS16575	COG1028	Short-chain dehydrogenase reductase Sdr
HWN34_RS16585	COG1937	Protein conserved in bacteria
HWN34_RS16595	COG0306	phosphate transporter
HWN34_RS16600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HWN34_RS16655	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HWN34_RS16660	COG2318	DinB family
HWN34_RS16700	COG2770	Histidine kinase
HWN34_RS16700	COG2208	phosphoserine phosphatase activity
HWN34_RS16710	COG0596	Alpha beta hydrolase
HWN34_RS16715	COG3903	Transcriptional regulator
HWN34_RS16715	COG3629	intracellular signal transduction
HWN34_RS16755	COG1595	DNA-templated transcription, initiation
HWN34_RS16810	COG2267	carboxylic ester hydrolase activity
HWN34_RS16830	COG1487	ribonuclease activity
HWN34_RS16845	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HWN34_RS16855	COG1131	(ABC) transporter
HWN34_RS16865	COG1725	Transcriptional regulator
HWN34_RS16870	COG4941	Belongs to the sigma-70 factor family
HWN34_RS16920	COG0456	acetyltransferase
HWN34_RS16925	COG0737	Belongs to the 5'-nucleotidase family
HWN34_RS16930	COG0235	Class ii aldolase
HWN34_RS16935	COG2160	L-arabinose isomerase activity
HWN34_RS16945	COG1609	Transcriptional regulator
HWN34_RS16955	COG1129	ABC transporter
HWN34_RS16960	COG4214	carbohydrate transport
HWN34_RS16975	COG0745	RESPONSE REGULATOR receiver
HWN34_RS16980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWN34_RS16985	COG1609	Transcriptional regulator
HWN34_RS16990	COG0745	RESPONSE REGULATOR receiver
HWN34_RS17015	COG2897	thiosulfate sulfurtransferase activity
HWN34_RS17050	COG3485	protocatechuate 3,4-dioxygenase
HWN34_RS17055	COG0735	belongs to the Fur family
HWN34_RS17060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HWN34_RS17065	COG1490	D-aminoacyl-tRNA deacylase activity
HWN34_RS17080	COG0789	Transcriptional regulator
HWN34_RS17100	COG1476	TRANSCRIPTIONal
HWN34_RS17160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWN34_RS17170	COG2226	methyltransferase
HWN34_RS17190	COG1309	transcriptional regulator
HWN34_RS17215	COG1388	LysM domain
HWN34_RS17215	COG0791	NLP P60 protein
HWN34_RS17215	COG3103	Sh3 type 3 domain protein
HWN34_RS17225	COG0438	transferase activity, transferring glycosyl groups
HWN34_RS17250	COG0588	phosphoglycerate mutase activity
HWN34_RS17255	COG1609	Transcriptional regulator
HWN34_RS17270	COG1196	nuclear chromosome segregation
HWN34_RS17275	COG0739	heme binding
HWN34_RS17290	COG0477	Major facilitator Superfamily
HWN34_RS17290	COG2814	Major facilitator Superfamily
HWN34_RS17305	COG2159	amidohydrolase
HWN34_RS17310	COG2828	Protein conserved in bacteria
HWN34_RS17315	COG2186	Transcriptional regulator
HWN34_RS17345	COG0501	Belongs to the peptidase M48B family
HWN34_RS17350	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HWN34_RS17350	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HWN34_RS17390	COG1289	transmembrane transporter activity
HWN34_RS17415	COG1012	belongs to the aldehyde dehydrogenase family
HWN34_RS17420	COG2318	DinB family
HWN34_RS17430	COG0655	NAD(P)H dehydrogenase (quinone) activity
HWN34_RS17435	COG0789	Transcriptional regulator
HWN34_RS17440	COG0586	Pfam SNARE associated Golgi protein
HWN34_RS17450	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HWN34_RS17455	COG2027	D-alanyl-D-alanine carboxypeptidase
HWN34_RS17465	COG0037	tRNA processing
HWN34_RS17480	COG0302	gtp cyclohydrolase
HWN34_RS17490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HWN34_RS17495	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HWN34_RS17510	COG1125	glycine betaine transport
HWN34_RS17510	COG0517	IMP dehydrogenase activity
HWN34_RS17515	COG1174	glycine betaine transport
HWN34_RS17520	COG1174	glycine betaine transport
HWN34_RS17525	COG1732	Glycine betaine
HWN34_RS17535	COG0477	Major facilitator Superfamily
HWN34_RS17550	COG0477	Major facilitator Superfamily
HWN34_RS17615	COG1012	belongs to the aldehyde dehydrogenase family
HWN34_RS17635	COG4585	Histidine kinase
HWN34_RS17640	COG2197	response regulator
HWN34_RS17660	COG0649	NAD binding
HWN34_RS17675	COG2197	response regulator
HWN34_RS17690	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HWN34_RS17695	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HWN34_RS17705	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HWN34_RS17725	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HWN34_RS17750	COG0739	heme binding
HWN34_RS17755	COG2205	protein histidine kinase activity
HWN34_RS17760	COG0745	RESPONSE REGULATOR receiver
HWN34_RS17770	COG1595	DNA-templated transcription, initiation
HWN34_RS17780	COG0671	phosphoesterase, PA-phosphatase related
HWN34_RS17790	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HWN34_RS17825	COG0248	Ppx GppA phosphatase
HWN34_RS17835	COG1082	Xylose isomerase domain protein TIM barrel
HWN34_RS17840	COG1309	transcriptional regulator
HWN34_RS17845	COG0129	dihydroxy-acid dehydratase activity
HWN34_RS17855	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HWN34_RS17875	COG0842	Transport permease protein
HWN34_RS17875	COG1129	ABC transporter
HWN34_RS17885	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HWN34_RS17890	COG0180	Tryptophanyl-tRNA synthetase
HWN34_RS17920	COG0123	including yeast histone deacetylase and acetoin utilization protein
HWN34_RS17975	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HWN34_RS17980	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HWN34_RS17985	COG0181	hydroxymethylbilane synthase activity
HWN34_RS17990	COG1648	precorrin-2 dehydrogenase activity
HWN34_RS17990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HWN34_RS17995	COG0113	porphobilinogen synthase activity
HWN34_RS18015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWN34_RS18020	COG0018	arginyl-trna synthetase
HWN34_RS18025	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HWN34_RS18050	COG1690	Belongs to the RtcB family
HWN34_RS18055	COG0659	secondary active sulfate transmembrane transporter activity
HWN34_RS18090	COG2826	transposase and inactivated derivatives, IS30 family
HWN34_RS18110	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HWN34_RS18115	COG0406	alpha-ribazole phosphatase activity
HWN34_RS18125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWN34_RS18130	COG0785	Cytochrome C biogenesis protein
HWN34_RS18140	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HWN34_RS18155	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HWN34_RS18160	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HWN34_RS18165	COG0163	prenyltransferase activity
HWN34_RS18180	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HWN34_RS18195	COG1301	dicarboxylic acid transport
HWN34_RS18210	COG1131	(ABC) transporter
HWN34_RS18215	COG3559	Exporter of polyketide antibiotics
HWN34_RS18245	COG0183	Belongs to the thiolase family
HWN34_RS18260	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HWN34_RS18265	COG1674	ftsk spoiiie
HWN34_RS18365	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HWN34_RS18415	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HWN34_RS18425	COG2226	methyltransferase
HWN34_RS18450	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HWN34_RS18455	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HWN34_RS18460	COG0649	NAD binding
HWN34_RS18470	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HWN34_RS18475	COG1034	ATP synthesis coupled electron transport
HWN34_RS18480	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HWN34_RS18485	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HWN34_RS18490	COG0839	Belongs to the complex I subunit 6 family
HWN34_RS18495	COG0713	ATP synthesis coupled electron transport
HWN34_RS18500	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HWN34_RS18510	COG1007	ATP synthesis coupled electron transport
HWN34_RS18515	COG0514	ATP-dependent DNA helicase (RecQ)
HWN34_RS18535	COG0561	phosphatase activity
HWN34_RS18545	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HWN34_RS18560	COG3104	oligopeptide transport
HWN34_RS18585	COG0488	(ABC) transporter
HWN34_RS18595	COG0702	epimerase
HWN34_RS18600	COG1733	regulation of RNA biosynthetic process
HWN34_RS18605	COG1013	pyruvate-flavodoxin oxidoreductase activity
HWN34_RS18610	COG0674	pyruvate-flavodoxin oxidoreductase activity
HWN34_RS18610	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HWN34_RS18615	COG2197	response regulator
HWN34_RS18620	COG4585	Histidine kinase
HWN34_RS18630	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HWN34_RS18635	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HWN34_RS18640	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HWN34_RS18645	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HWN34_RS18650	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HWN34_RS18655	COG0839	Belongs to the complex I subunit 6 family
HWN34_RS18660	COG0713	ATP synthesis coupled electron transport
HWN34_RS18665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HWN34_RS18675	COG1007	ATP synthesis coupled electron transport
HWN34_RS18680	COG0501	Belongs to the peptidase M48B family
HWN34_RS18685	COG3304	Inner membrane component domain
HWN34_RS18690	COG2261	transglycosylase associated protein
HWN34_RS18695	COG1666	GTP binding
HWN34_RS18710	COG0702	epimerase
HWN34_RS18715	COG0402	S-adenosylhomocysteine deaminase activity
HWN34_RS18730	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HWN34_RS18735	COG2030	dehydratase
HWN34_RS18745	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HWN34_RS18755	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HWN34_RS18760	COG0436	Aminotransferase
HWN34_RS18785	COG0081	regulation of translation
HWN34_RS18795	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HWN34_RS18800	COG0222	ribosome binding
HWN34_RS18805	COG0085	RNA polymerase activity
HWN34_RS18810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HWN34_RS18845	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HWN34_RS18850	COG0049	tRNA binding
HWN34_RS18855	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HWN34_RS18875	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HWN34_RS18885	COG0051	transcription antitermination factor activity, RNA binding
HWN34_RS18890	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HWN34_RS18895	COG0088	Forms part of the polypeptide exit tunnel
HWN34_RS18900	COG0089	rRNA binding
HWN34_RS18905	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HWN34_RS18910	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HWN34_RS18915	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HWN34_RS18920	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HWN34_RS18925	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HWN34_RS18930	COG0255	Belongs to the universal ribosomal protein uL29 family
HWN34_RS18935	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HWN34_RS18940	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HWN34_RS18945	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HWN34_RS18950	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HWN34_RS18955	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HWN34_RS18960	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HWN34_RS18965	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HWN34_RS18970	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HWN34_RS18975	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HWN34_RS18980	COG1841	ribosomal large subunit assembly
HWN34_RS18985	COG0200	Binds to the 23S rRNA
HWN34_RS18990	COG0201	protein transport
HWN34_RS18995	COG0563	adenylate kinase activity
HWN34_RS19005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HWN34_RS19010	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HWN34_RS19015	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HWN34_RS19020	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HWN34_RS19030	COG0203	ribosomal protein L17
HWN34_RS19035	COG0101	tRNA pseudouridine synthase activity
HWN34_RS19045	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HWN34_RS19050	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HWN34_RS19055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HWN34_RS19060	COG1072	(Pantothenic acid kinase))
HWN34_RS19075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HWN34_RS19090	COG4977	sequence-specific DNA binding
HWN34_RS19105	COG0736	holo-[acyl-carrier-protein] synthase activity
HWN34_RS19170	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HWN34_RS19180	COG0802	atpase or kinase
HWN34_RS19205	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HWN34_RS19240	COG0726	polysaccharide deacetylase
HWN34_RS19255	COG4221	oxidoreductase activity
HWN34_RS19260	COG0583	DNA-binding transcription factor activity
HWN34_RS19270	COG2197	response regulator
HWN34_RS19275	COG1595	DNA-templated transcription, initiation
HWN34_RS19285	COG0516	GMP reductase activity
HWN34_RS19295	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HWN34_RS19340	COG1012	belongs to the aldehyde dehydrogenase family
HWN34_RS19360	COG0519	Catalyzes the synthesis of GMP from XMP
HWN34_RS19360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HWN34_RS19370	COG1028	Short-chain dehydrogenase reductase Sdr
HWN34_RS19415	COG2197	response regulator
HWN34_RS19420	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HWN34_RS19465	COG1846	Transcriptional regulator
HWN34_RS19465	COG0456	acetyltransferase
HWN34_RS19475	COG1228	amidohydrolase
HWN34_RS19495	COG0791	NLP P60 protein
HWN34_RS19535	COG2066	Belongs to the glutaminase family
HWN34_RS19540	COG1196	nuclear chromosome segregation
HWN34_RS19540	COG0739	heme binding
HWN34_RS19540	COG0741	lytic transglycosylase activity
HWN34_RS19545	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HWN34_RS19550	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HWN34_RS19550	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HWN34_RS19565	COG0714	Associated with various cellular activities
HWN34_RS19570	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HWN34_RS19575	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HWN34_RS19580	COG0045	succinate-CoA ligase (ADP-forming) activity
HWN34_RS19610	COG0138	bifunctional purine biosynthesis protein purh
HWN34_RS19620	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HWN34_RS19645	COG0039	L-malate dehydrogenase activity
HWN34_RS19665	COG1012	belongs to the aldehyde dehydrogenase family
HWN34_RS19675	COG4175	Glycine betaine
HWN34_RS19675	COG0517	IMP dehydrogenase activity
HWN34_RS19705	COG0395	ABC-type sugar transport system, permease component
HWN34_RS19710	COG1175	transmembrane transport
HWN34_RS19735	COG2362	D-Aminopeptidase
HWN34_RS19740	COG1609	Transcriptional regulator
HWN34_RS19750	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HWN34_RS19755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWN34_RS19765	COG0754	glutathionylspermidine amidase activity
HWN34_RS19775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HWN34_RS19810	COG0180	Tryptophanyl-tRNA synthetase
HWN34_RS19850	COG1295	ribonuclease BN
HWN34_RS19865	COG1408	metallophosphoesterase
HWN34_RS19885	COG1309	transcriptional regulator
HWN34_RS19900	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HWN34_RS19905	COG1053	succinate dehydrogenase
HWN34_RS19915	COG2009	succinate dehydrogenase
HWN34_RS19955	COG1215	transferase activity, transferring glycosyl groups
HWN34_RS19960	COG1595	DNA-templated transcription, initiation
HWN34_RS20030	COG1216	Glycosyl transferase, family 2
HWN34_RS20040	COG1083	cytidylyl-transferase
HWN34_RS20045	COG2089	acid synthase
HWN34_RS20055	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HWN34_RS20055	COG1473	amidohydrolase
HWN34_RS20065	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HWN34_RS20150	COG2814	Major facilitator Superfamily
HWN34_RS20155	COG0583	DNA-binding transcription factor activity
HWN34_RS20175	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HWN34_RS20200	COG2205	protein histidine kinase activity
HWN34_RS20205	COG0745	RESPONSE REGULATOR receiver
HWN34_RS20210	COG1595	DNA-templated transcription, initiation
HWN34_RS20255	COG1012	belongs to the aldehyde dehydrogenase family
HWN34_RS20275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HWN34_RS20310	COG4770	biotin carboxylase activity
HWN34_RS20320	COG0424	maF-like protein
HWN34_RS20335	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HWN34_RS20345	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HWN34_RS20350	COG1024	Enoyl-CoA hydratase
HWN34_RS20360	COG2986	histidine ammonia-lyase
HWN34_RS20380	COG1136	(ABC) transporter
HWN34_RS20385	COG1064	alcohol dehydrogenase
HWN34_RS20390	COG2318	DinB family
HWN34_RS20415	COG2255	four-way junction helicase activity
HWN34_RS20420	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HWN34_RS20435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HWN34_RS20445	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HWN34_RS20480	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HWN34_RS20505	COG1331	Highly conserved protein containing a thioredoxin domain
HWN34_RS20525	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HWN34_RS20555	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HWN34_RS20570	COG1414	Transcriptional regulator
HWN34_RS20575	COG0251	oxidation-reduction process
HWN34_RS20660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HWN34_RS20695	COG2894	cell division
HWN34_RS20760	COG2814	Major facilitator Superfamily
HWN34_RS20765	COG0656	L-ascorbic acid biosynthetic process
HWN34_RS20770	COG2304	oxidoreductase activity
HWN34_RS20780	COG3548	integral membrane protein
HWN34_RS20790	COG0667	Aldo Keto reductase
HWN34_RS20795	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HWN34_RS20800	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HWN34_RS20820	COG0450	alkyl hydroperoxide reductase
HWN34_RS20825	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HWN34_RS20835	COG1136	(ABC) transporter
HWN34_RS20855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HWN34_RS20870	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HWN34_RS20880	COG0114	fumarate hydratase activity
HWN34_RS20890	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HWN34_RS20890	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HWN34_RS20900	COG0515	serine threonine protein kinase
HWN34_RS20925	COG0778	Nitroreductase
HWN34_RS20930	COG1722	exodeoxyribonuclease VII activity
HWN34_RS20935	COG1570	exodeoxyribonuclease VII activity
HWN34_RS20940	COG0531	amino acid
HWN34_RS20945	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HWN34_RS20960	COG0012	GTP binding
HWN34_RS20990	COG0709	Synthesizes selenophosphate from selenide and ATP
HWN34_RS21025	COG0406	alpha-ribazole phosphatase activity
HWN34_RS21050	COG0745	RESPONSE REGULATOR receiver
HWN34_RS21125	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HWN34_RS21130	COG4977	sequence-specific DNA binding
HWN34_RS21145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HWN34_RS21170	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HWN34_RS21200	COG1028	Short-chain dehydrogenase reductase Sdr
HWN34_RS21210	COG3655	Transcriptional regulator
HWN34_RS21230	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWN34_RS21230	COG1902	pentaerythritol trinitrate reductase activity
HWN34_RS21245	COG1960	acyl-CoA dehydrogenase activity
HWN34_RS21260	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HWN34_RS21265	COG1309	transcriptional regulator
HWN34_RS21275	COG1946	Acyl-CoA thioesterase
HWN34_RS21320	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWN34_RS21330	COG3960	tartronate-semialdehyde synthase activity
HWN34_RS21350	COG1472	Belongs to the glycosyl hydrolase 3 family
HWN34_RS21355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HWN34_RS21400	COG3718	enzyme involved in inositol metabolism
HWN34_RS21405	COG3962	Belongs to the TPP enzyme family
HWN34_RS21420	COG1131	(ABC) transporter
HWN34_RS21450	COG3903	Transcriptional regulator
HWN34_RS21450	COG3629	intracellular signal transduction
HWN34_RS21520	COG0629	single-stranded DNA binding
HWN34_RS21555	COG1136	(ABC) transporter
HWN34_RS21575	COG0667	Aldo Keto reductase
HWN34_RS21580	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HWN34_RS21610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWN34_RS21625	COG1486	melibiose metabolic process
HWN34_RS21635	COG0668	transmembrane transport
HWN34_RS21650	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HWN34_RS21670	COG0583	DNA-binding transcription factor activity
HWN34_RS21710	COG4266	Belongs to the allantoicase family
HWN34_RS21745	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HWN34_RS21750	COG0076	glutamate decarboxylase activity
HWN34_RS21755	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HWN34_RS21760	COG1113	amino acid transport
HWN34_RS21765	COG1113	amino acid transport
HWN34_RS21770	COG1268	BioY protein
HWN34_RS21775	COG1113	amino acid transport
HWN34_RS21790	COG4552	Acetyltransferase involved in intracellular survival and related
HWN34_RS21800	COG0475	glutathione-regulated potassium exporter activity
HWN34_RS21805	COG3594	Acyltransferase
HWN34_RS21825	COG0544	peptidyl-prolyl cis-trans isomerase activity
HWN34_RS21830	COG0740	serine-type endopeptidase activity
HWN34_RS21835	COG0740	serine-type endopeptidase activity
HWN34_RS21840	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HWN34_RS21850	COG0525	valine-tRNA ligase activity
HWN34_RS21855	COG0285	dihydrofolate synthase activity
HWN34_RS21865	COG0105	UTP biosynthetic process
HWN34_RS21870	COG1077	Cell shape determining protein MreB Mrl
HWN34_RS21890	COG0772	Belongs to the SEDS family
HWN34_RS21920	COG1530	ribonuclease E activity
HWN34_RS21925	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HWN34_RS21930	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HWN34_RS21935	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HWN34_RS21955	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HWN34_RS21965	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HWN34_RS21985	COG0501	Belongs to the peptidase M48B family
HWN34_RS22000	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HWN34_RS22010	COG0799	negative regulation of ribosome biogenesis
HWN34_RS22015	COG0588	phosphoglycerate mutase activity
HWN34_RS22040	COG0495	leucyl-tRNA aminoacylation
HWN34_RS22050	COG1307	EDD domain protein, DegV family
HWN34_RS22055	COG1555	photosystem II stabilization
HWN34_RS22065	COG2353	YceI-like domain
HWN34_RS22080	COG0268	Binds directly to 16S ribosomal RNA
HWN34_RS22085	COG0481	GTPase activity
HWN34_RS22120	COG0484	heat shock protein binding
HWN34_RS22135	COG0793	Belongs to the peptidase S41A family
HWN34_RS22135	COG4946	Tricorn protease homolog
HWN34_RS22140	COG0537	adenosine 5'-monophosphoramidase activity
HWN34_RS22145	COG1234	tRNA 3'-trailer cleavage
HWN34_RS22165	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HWN34_RS22170	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HWN34_RS22195	COG1486	melibiose metabolic process
HWN34_RS22200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWN34_RS22225	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HWN34_RS22235	COG2315	Protein conserved in bacteria
HWN34_RS22245	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HWN34_RS22260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HWN34_RS22275	COG1381	Involved in DNA repair and RecF pathway recombination
HWN34_RS22280	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HWN34_RS22290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HWN34_RS22295	COG1121	(ABC) transporter
HWN34_RS22305	COG0423	glycine-tRNA ligase activity
HWN34_RS22375	COG0189	ligase activity
HWN34_RS22385	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HWN34_RS22400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HWN34_RS22405	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HWN34_RS22415	COG3467	pyridoxamine 5'-phosphate
HWN34_RS22445	COG1940	carbohydrate kinase activity
HWN34_RS22445	COG1846	Transcriptional regulator
HWN34_RS22450	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HWN34_RS22480	COG0574	Belongs to the PEP-utilizing enzyme family
HWN34_RS22480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HWN34_RS22495	COG1324	tolerance protein
HWN34_RS22505	COG0829	nickel cation binding
HWN34_RS22510	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HWN34_RS22515	COG0830	nickel cation binding
HWN34_RS22520	COG0804	urea catabolic process
HWN34_RS22525	COG0832	Belongs to the urease beta subunit family
HWN34_RS22535	COG0738	Major facilitator superfamily
HWN34_RS22540	COG1028	Short-chain dehydrogenase reductase Sdr
HWN34_RS22555	COG2226	methyltransferase
HWN34_RS22595	COG1070	Carbohydrate kinase
HWN34_RS22615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HWN34_RS22620	COG0358	DNA primase activity
HWN34_RS22630	COG3290	protein histidine kinase activity
HWN34_RS22635	COG4565	transcriptional regulatory protein
HWN34_RS22640	COG2851	Citrate transporter
HWN34_RS22650	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HWN34_RS22670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWN34_RS22695	COG1028	Short-chain dehydrogenase reductase Sdr
HWN34_RS22710	COG2890	protein-(glutamine-N5) methyltransferase activity
HWN34_RS22725	COG1077	Cell shape determining protein MreB Mrl
HWN34_RS22750	COG2130	NADP-dependent
HWN34_RS22755	COG1764	response to oxidative stress
HWN34_RS22785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HWN34_RS22790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWN34_RS22795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HWN34_RS22810	COG1741	Belongs to the pirin family
HWN34_RS22825	COG0789	Transcriptional regulator
HWN34_RS22830	COG0667	Aldo Keto reductase
HWN34_RS22845	COG2197	response regulator
HWN34_RS22850	COG4585	Histidine kinase
HWN34_RS22870	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HWN34_RS22915	COG1358	cellular component organization or biogenesis
HWN34_RS22930	COG0586	Pfam SNARE associated Golgi protein
HWN34_RS23035	COG3845	ABC transporter
HWN34_RS23050	COG1657	PFAM Prenyltransferase squalene oxidase
HWN34_RS23055	COG0438	transferase activity, transferring glycosyl groups
HWN34_RS23085	COG0477	Major facilitator Superfamily
HWN34_RS23090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HWN34_RS23095	COG3547	Transposase (IS116 IS110 IS902 family)
HWN34_RS23100	COG1960	acyl-CoA dehydrogenase activity
HWN34_RS23115	COG2197	response regulator
HWN34_RS23120	COG0346	lactoylglutathione lyase activity
HWN34_RS23125	COG4585	Histidine kinase
HWN34_RS23135	COG1131	(ABC) transporter
HWN34_RS23150	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HWN34_RS23165	COG2826	transposase and inactivated derivatives, IS30 family
HWN34_RS23170	COG0800	Aldolase
HWN34_RS23175	COG3022	response to hydroperoxide
HWN34_RS23215	COG1733	regulation of RNA biosynthetic process
HWN34_RS23235	COG2226	methyltransferase
HWN34_RS23240	COG0384	phenazine biosynthesis protein PhzF
HWN34_RS23260	COG0076	glutamate decarboxylase activity
HWN34_RS23270	COG2814	Major facilitator Superfamily
HWN34_RS23275	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HWN34_RS23285	COG1834	amidinotransferase
HWN34_RS23305	COG1120	ATPase activity
HWN34_RS23310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWN34_RS23315	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HWN34_RS23360	COG1994	Peptidase M50
HWN34_RS23365	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HWN34_RS23380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HWN34_RS23380	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HWN34_RS23385	COG2132	Multicopper oxidase
HWN34_RS23405	COG0174	glutamine synthetase
HWN34_RS23440	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HWN34_RS23460	COG1228	amidohydrolase
HWN34_RS23475	COG1609	Transcriptional regulator
HWN34_RS23480	COG2182	Extracellular solute-binding protein
HWN34_RS23485	COG1175	transmembrane transport
HWN34_RS23490	COG0395	ABC-type sugar transport system, permease component
HWN34_RS23495	COG0366	Alpha amylase catalytic
HWN34_RS23515	COG1309	transcriptional regulator
HWN34_RS23535	COG0745	RESPONSE REGULATOR receiver
HWN34_RS23565	COG1012	belongs to the aldehyde dehydrogenase family
HWN34_RS23625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HWN34_RS23630	COG2326	polyphosphate kinase activity
HWN34_RS23640	COG2376	Dihydroxyacetone kinase
HWN34_RS23650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HWN34_RS23685	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HWN34_RS23690	COG0321	lipoyl(octanoyl) transferase activity
HWN34_RS23700	COG0456	acetyltransferase
HWN34_RS23725	COG4221	oxidoreductase activity
HWN34_RS23740	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HWN34_RS23750	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWN34_RS23755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HWN34_RS23760	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HWN34_RS23765	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HWN34_RS23775	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HWN34_RS23820	COG2197	response regulator
HWN34_RS23825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWN34_RS23830	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HWN34_RS23855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWN34_RS23860	COG1104	cysteine desulfurase activity
HWN34_RS23865	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HWN34_RS23870	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HWN34_RS23880	COG1376	ErfK ybiS ycfS ynhG family protein
HWN34_RS23890	COG1845	cytochrome c oxidase, subunit III
HWN34_RS23895	COG2010	Cytochrome c
HWN34_RS23900	COG0723	plastoquinol--plastocyanin reductase activity
HWN34_RS23905	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HWN34_RS23910	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HWN34_RS23915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HWN34_RS23920	COG1929	Belongs to the glycerate kinase type-1 family
HWN34_RS23930	COG0745	RESPONSE REGULATOR receiver
HWN34_RS23935	COG5002	protein histidine kinase activity
HWN34_RS23950	COG0705	Rhomboid family
HWN34_RS23985	COG0438	transferase activity, transferring glycosyl groups
HWN34_RS24005	COG0003	Pfam Anion-transporting ATPase
HWN34_RS24015	COG1940	carbohydrate kinase activity
HWN34_RS24040	COG4585	Histidine kinase
HWN34_RS24045	COG2197	response regulator
HWN34_RS24050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HWN34_RS24065	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HWN34_RS24070	COG0243	molybdopterin cofactor binding
HWN34_RS24075	COG2193	ferroxidase activity
HWN34_RS24080	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HWN34_RS24085	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HWN34_RS24090	COG2815	serine threonine protein kinase
HWN34_RS24090	COG0515	serine threonine protein kinase
HWN34_RS24095	COG2022	thiamine diphosphate biosynthetic process
HWN34_RS24105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWN34_RS24105	COG2022	thiamine diphosphate biosynthetic process
HWN34_RS24110	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWN34_RS24120	COG0352	thiamine-phosphate diphosphorylase activity
HWN34_RS24140	COG1309	transcriptional regulator
HWN34_RS24150	COG1121	(ABC) transporter
HWN34_RS24155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HWN34_RS24175	COG0714	Associated with various cellular activities
HWN34_RS24185	COG0275	rRNA processing
HWN34_RS24200	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HWN34_RS24210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HWN34_RS24215	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HWN34_RS24225	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HWN34_RS24230	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HWN34_RS24235	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HWN34_RS24250	COG1799	cell septum assembly
HWN34_RS24260	COG3599	regulation of cell shape
HWN34_RS24270	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HWN34_RS24280	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HWN34_RS24290	COG2153	protein acetylation
HWN34_RS24305	COG0515	serine threonine protein kinase
HWN34_RS24325	COG0587	DNA-directed DNA polymerase activity
HWN34_RS24335	COG1432	Conserved Protein
HWN34_RS24355	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HWN34_RS24375	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HWN34_RS24380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HWN34_RS24385	COG0131	Imidazoleglycerol-phosphate dehydratase
HWN34_RS24395	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HWN34_RS24400	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HWN34_RS24405	COG0251	oxidation-reduction process
HWN34_RS24410	COG0107	imidazoleglycerol-phosphate synthase activity
HWN34_RS24425	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HWN34_RS24455	COG0134	indole-3-glycerol-phosphate synthase activity
HWN34_RS24460	COG0133	tryptophan synthase activity
HWN34_RS24465	COG0159	tryptophan synthase activity
HWN34_RS24475	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HWN34_RS24485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HWN34_RS24490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWN34_RS24520	COG0069	glutamate synthase activity
HWN34_RS24520	COG0070	glutamate synthase
HWN34_RS24520	COG0067	glutamate synthase
HWN34_RS24535	COG1278	Cold shock
HWN34_RS24540	COG0513	Belongs to the DEAD box helicase family
HWN34_RS24550	COG1605	Chorismate mutase
HWN34_RS24550	COG0287	Prephenate dehydrogenase
HWN34_RS24580	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HWN34_RS24585	COG0737	Belongs to the 5'-nucleotidase family
HWN34_RS24620	COG0559	Belongs to the binding-protein-dependent transport system permease family
HWN34_RS24630	COG2746	aminoglycoside 3-N-acetyltransferase activity
HWN34_RS24635	COG2050	protein possibly involved in aromatic compounds catabolism
HWN34_RS24655	COG1643	Atp-dependent helicase
HWN34_RS24660	COG2226	methyltransferase
HWN34_RS24680	COG0237	dephospho-CoA kinase activity
HWN34_RS24700	COG1288	antiporter activity
HWN34_RS24750	COG0477	Major facilitator Superfamily
HWN34_RS24760	COG0584	glycerophosphoryl diester phosphodiesterase
HWN34_RS24770	COG0556	nucleotide-excision repair
HWN34_RS24790	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HWN34_RS24795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWN34_RS24805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HWN34_RS24820	COG0322	excinuclease ABC activity
HWN34_RS24825	COG1660	Displays ATPase and GTPase activities
HWN34_RS24835	COG1481	regulation of sporulation
HWN34_RS24840	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HWN34_RS24845	COG0126	phosphoglycerate kinase activity
HWN34_RS24850	COG0149	triose-phosphate isomerase activity
HWN34_RS24855	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HWN34_RS24865	COG0166	Belongs to the GPI family
HWN34_RS24870	COG0363	glucosamine-6-phosphate deaminase activity
HWN34_RS24885	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HWN34_RS24890	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HWN34_RS24895	COG0109	protoheme IX farnesyltransferase activity
HWN34_RS24910	COG1612	heme a metabolic process
HWN34_RS24920	COG1131	(ABC) transporter
HWN34_RS24935	COG0719	Fe-S assembly protein
HWN34_RS24945	COG0396	ATPase activity
HWN34_RS24950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HWN34_RS24955	COG0822	iron-sulfur transferase activity
HWN34_RS24965	COG2171	N-acyltransferase activity
HWN34_RS25000	COG2197	response regulator
HWN34_RS25005	COG4585	Histidine kinase
HWN34_RS25035	COG1902	pentaerythritol trinitrate reductase activity
HWN34_RS25040	COG5285	phytanoyl-CoA dioxygenase
HWN34_RS25045	COG1917	Cupin 2, conserved barrel domain protein
HWN34_RS25055	COG0456	acetyltransferase
HWN34_RS25060	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HWN34_RS25090	COG1797	cobyrinic acid a,c-diamide synthase activity
HWN34_RS25105	COG1492	cobalamin metabolic process
HWN34_RS25110	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HWN34_RS25125	COG0235	Class ii aldolase
HWN34_RS25145	COG0488	(ABC) transporter
HWN34_RS25200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HWN34_RS25220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HWN34_RS25235	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWN34_RS25240	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HWN34_RS25250	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HWN34_RS25270	COG2261	transglycosylase associated protein
HWN34_RS25275	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HWN34_RS25285	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HWN34_RS25295	COG2186	Transcriptional regulator
HWN34_RS25300	COG2807	transmembrane transport
HWN34_RS25315	COG0560	Phosphoserine phosphatase
HWN34_RS25315	COG3830	Belongs to the UPF0237 family
HWN34_RS25320	COG0842	Transport permease protein
HWN34_RS25320	COG1716	ATPase activity
HWN34_RS25320	COG1131	(ABC) transporter
HWN34_RS25345	COG2197	response regulator
HWN34_RS25360	COG1119	ATPase activity
HWN34_RS25380	COG1881	PFAM PEBP family protein
HWN34_RS25390	COG2094	Belongs to the DNA glycosylase MPG family
HWN34_RS25425	COG0647	UMP catabolic process
HWN34_RS25445	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HWN34_RS25450	COG0497	DNA recombination
HWN34_RS25465	COG0297	glycogen (starch) synthase activity
HWN34_RS25480	COG3387	PFAM Glycoside hydrolase 15-related
HWN34_RS25485	COG0504	CTP synthase activity
HWN34_RS25490	COG0494	nUDIX hydrolase
HWN34_RS25500	COG0686	Belongs to the AlaDH PNT family
HWN34_RS25515	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HWN34_RS25520	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HWN34_RS25525	COG1187	pseudouridine synthase activity
HWN34_RS25535	COG1397	ADP-ribosylglycohydrolase
HWN34_RS25540	COG3541	Predicted nucleotidyltransferase
HWN34_RS25555	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HWN34_RS25565	COG1160	GTP binding
HWN34_RS25585	COG0438	transferase activity, transferring glycosyl groups
HWN34_RS25605	COG0671	phosphoesterase, PA-phosphatase related
HWN34_RS25615	COG0477	Major facilitator Superfamily
HWN34_RS25620	COG1799	cell septum assembly
HWN34_RS25660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWN34_RS25680	COG0330	HflC and HflK could
HWN34_RS25695	COG0587	DNA-directed DNA polymerase activity
HWN34_RS25700	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HWN34_RS25765	COG1216	Glycosyl transferase, family 2
HWN34_RS25790	COG2755	lipolytic protein G-D-S-L family
HWN34_RS25810	COG3973	AAA domain
HWN34_RS25815	COG2188	Transcriptional regulator
HWN34_RS25820	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HWN34_RS25845	COG1309	transcriptional regulator
HWN34_RS25890	COG3876	Protein conserved in bacteria
HWN34_RS25900	COG0488	(ABC) transporter
HWN34_RS25915	COG0318	PFAM AMP-dependent synthetase and ligase
HWN34_RS25925	COG1960	acyl-CoA dehydrogenase activity
HWN34_RS25945	COG2149	membrane
HWN34_RS25950	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HWN34_RS25990	COG3265	gluconokinase activity
HWN34_RS26000	COG3012	SEC-C Motif Domain Protein
HWN34_RS26005	COG3189	MarR family transcriptional regulator
HWN34_RS26015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HWN34_RS26050	COG0667	Aldo Keto reductase
HWN34_RS26055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWN34_RS26065	COG0598	Magnesium transport protein CorA
HWN34_RS26085	COG0215	cysteine-tRNA ligase activity
HWN34_RS26100	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HWN34_RS26105	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HWN34_RS26110	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HWN34_RS26120	COG1410	methionine synthase
HWN34_RS26120	COG0646	methionine synthase
HWN34_RS26130	COG0747	negative chemotaxis
HWN34_RS26135	COG2197	response regulator
HWN34_RS26145	COG0517	IMP dehydrogenase activity
HWN34_RS26145	COG1994	Peptidase M50
HWN34_RS26165	COG1222	aaa ATPase
HWN34_RS26170	COG4122	O-methyltransferase activity
HWN34_RS26180	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HWN34_RS26185	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HWN34_RS26200	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HWN34_RS26235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HWN34_RS26240	COG0805	protein transport
HWN34_RS26255	COG2124	cytochrome p450
HWN34_RS26285	COG0564	pseudouridine synthase activity
HWN34_RS26295	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HWN34_RS26305	COG1595	DNA-templated transcription, initiation
HWN34_RS26315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HWN34_RS26320	COG4175	Glycine betaine
HWN34_RS26320	COG0517	IMP dehydrogenase activity
HWN34_RS26345	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HWN34_RS26350	COG0531	amino acid
HWN34_RS26360	COG0174	glutamine synthetase
HWN34_RS26365	COG1012	belongs to the aldehyde dehydrogenase family
HWN34_RS26400	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HWN34_RS26410	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HWN34_RS26415	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HWN34_RS26420	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HWN34_RS26425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HWN34_RS26435	COG5002	protein histidine kinase activity
HWN34_RS26440	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HWN34_RS26445	COG0072	phenylalanine-tRNA ligase activity
HWN34_RS26445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWN34_RS26475	COG0697	spore germination
HWN34_RS26480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWN34_RS26520	COG2838	Isocitrate dehydrogenase
HWN34_RS26535	COG1309	transcriptional regulator
HWN34_RS26550	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HWN34_RS26590	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HWN34_RS26595	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HWN34_RS26600	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HWN34_RS26605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HWN34_RS26610	COG1438	arginine binding
HWN34_RS26615	COG4585	Histidine kinase
HWN34_RS26620	COG2197	response regulator
HWN34_RS26630	COG2409	Drug exporters of the RND superfamily
HWN34_RS26635	COG0385	Bile acid
HWN34_RS26645	COG0165	Argininosuccinate lyase
HWN34_RS26665	COG0477	Major facilitator Superfamily
HWN34_RS26670	COG0204	Acyl-transferase
HWN34_RS26670	COG0318	PFAM AMP-dependent synthetase and ligase
HWN34_RS26675	COG0584	glycerophosphoryl diester phosphodiesterase
HWN34_RS26700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HWN34_RS26705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HWN34_RS26710	COG2011	ABC-type metal ion transport system permease component
HWN34_RS26715	COG1464	Belongs to the NlpA lipoprotein family
HWN34_RS26720	COG1464	Belongs to the NlpA lipoprotein family
HWN34_RS26735	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HWN34_RS26740	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HWN34_RS26740	COG1648	precorrin-2 dehydrogenase activity
HWN34_RS26815	COG0456	acetyltransferase
HWN34_RS26875	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HWN34_RS26880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HWN34_RS26895	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HWN34_RS26900	COG1560	Kdo2-lipid A biosynthetic process
HWN34_RS26905	COG0438	transferase activity, transferring glycosyl groups
HWN34_RS26915	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HWN34_RS26920	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HWN34_RS26925	COG0217	transcriptional regulatory protein
HWN34_RS26930	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HWN34_RS26935	COG0632	four-way junction helicase activity
HWN34_RS26940	COG2255	four-way junction helicase activity
HWN34_RS26950	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HWN34_RS26955	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HWN34_RS26960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HWN34_RS26965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HWN34_RS26975	COG1196	nuclear chromosome segregation
HWN34_RS26980	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HWN34_RS26990	COG0124	histidyl-tRNA synthetase
HWN34_RS27005	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HWN34_RS27020	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HWN34_RS27025	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HWN34_RS27030	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HWN34_RS27035	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HWN34_RS27040	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HWN34_RS27045	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HWN34_RS27050	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HWN34_RS27060	COG0006	proline dipeptidase activity
HWN34_RS27065	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HWN34_RS27070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HWN34_RS27080	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HWN34_RS27085	COG0540	Belongs to the ATCase OTCase family
HWN34_RS27090	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HWN34_RS27100	COG0505	Belongs to the CarA family
HWN34_RS27105	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HWN34_RS27110	COG0167	dihydroorotate dehydrogenase activity
HWN34_RS27115	COG0284	orotidine-5'-phosphate decarboxylase activity
HWN34_RS27130	COG1758	RNA polymerase activity
HWN34_RS27140	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HWN34_RS27155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HWN34_RS27170	COG2318	DinB family
HWN34_RS27175	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HWN34_RS27180	COG2390	Transcriptional regulator
HWN34_RS27220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HWN34_RS27240	COG0697	spore germination
HWN34_RS27245	COG2233	PERMEase
HWN34_RS27255	COG0738	Major facilitator superfamily
HWN34_RS27260	COG1846	Transcriptional regulator
HWN34_RS27260	COG1940	carbohydrate kinase activity
HWN34_RS27265	COG1090	epimerase
HWN34_RS27280	COG3201	nicotinamide mononucleotide transporter
HWN34_RS27285	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HWN34_RS27285	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HWN34_RS27290	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HWN34_RS27295	COG0140	phosphoribosyl-ATP diphosphatase activity
HWN34_RS27300	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HWN34_RS27330	COG1960	acyl-CoA dehydrogenase activity
HWN34_RS27350	COG0463	Glycosyl transferase, family 2
HWN34_RS27355	COG3030	protein affecting phage T7 exclusion by the F plasmid
HWN34_RS27365	COG2270	Major facilitator Superfamily
HWN34_RS27375	COG2364	Membrane
HWN34_RS27380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWN34_RS27465	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HWN34_RS27485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HWN34_RS27495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HWN34_RS27525	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HWN34_RS27545	COG1716	ATPase activity
HWN34_RS27565	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HWN34_RS27575	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HWN34_RS27575	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HWN34_RS27615	COG0539	negative regulation of cytoplasmic translation
HWN34_RS27635	COG0697	spore germination
HWN34_RS27650	COG0697	spore germination
HWN34_RS27670	COG4251	negative regulation of phosphorylation
HWN34_RS27680	COG0154	amidase activity
HWN34_RS27720	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HWN34_RS27765	COG2826	transposase and inactivated derivatives, IS30 family
HWN34_RS27775	COG1982	Orn Lys Arg decarboxylase major
HWN34_RS27785	COG1968	undecaprenyl-diphosphatase activity
HWN34_RS27805	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HWN34_RS27865	COG0110	maltose O-acetyltransferase activity
HWN34_RS27875	COG1832	CoA-binding protein
HWN34_RS27880	COG1739	Uncharacterized protein family UPF0029
HWN34_RS27900	COG1595	DNA-templated transcription, initiation
HWN34_RS27915	COG0420	3'-5' exonuclease activity
HWN34_RS27920	COG0419	ATPase involved in DNA repair
HWN34_RS27925	COG1522	sequence-specific DNA binding
HWN34_RS27935	COG1028	Short-chain dehydrogenase reductase Sdr
HWN34_RS27950	COG0626	cystathionine gamma-synthase activity
HWN34_RS27975	COG2188	Transcriptional regulator
HWN34_RS27980	COG1940	carbohydrate kinase activity
HWN34_RS27995	COG3663	DNA glycosylase
HWN34_RS28000	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HWN34_RS28020	COG0456	acetyltransferase
HWN34_RS28025	COG0488	(ABC) transporter
HWN34_RS28030	COG0488	(ABC) transporter
HWN34_RS28040	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HWN34_RS28045	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HWN34_RS28050	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HWN34_RS28075	COG0791	NLP P60 protein
HWN34_RS28090	COG0831	urea catabolic process
HWN34_RS28095	COG0832	Belongs to the urease beta subunit family
HWN34_RS28100	COG0804	urea catabolic process
HWN34_RS28110	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HWN34_RS28115	COG0829	nickel cation binding
HWN34_RS28120	COG4552	Acetyltransferase involved in intracellular survival and related
HWN34_RS28125	COG0204	Acyl-transferase
HWN34_RS28170	COG2175	clavaminate synthase activity
HWN34_RS28180	COG0435	Glutathione S-transferase
HWN34_RS28195	COG2208	phosphoserine phosphatase activity
HWN34_RS28195	COG2770	Histidine kinase
HWN34_RS28210	COG0205	6-phosphofructokinase activity
HWN34_RS28215	COG3442	glutamine amidotransferase
HWN34_RS28225	COG0242	peptide deformylase activity
HWN34_RS28235	COG1960	acyl-CoA dehydrogenase activity
HWN34_RS28255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWN34_RS28280	COG1175	transmembrane transport
HWN34_RS28285	COG0395	ABC-type sugar transport system, permease component
HWN34_RS28290	COG2723	6-phospho-beta-galactosidase activity
HWN34_RS28295	COG0501	Belongs to the peptidase M48B family
HWN34_RS28340	COG4251	negative regulation of phosphorylation
HWN34_RS28345	COG0784	Response regulator, receiver
HWN34_RS28365	COG0656	L-ascorbic acid biosynthetic process
HWN34_RS28375	COG1595	DNA-templated transcription, initiation
HWN34_RS28385	COG1132	(ABC) transporter
HWN34_RS28405	COG3693	PFAM glycoside hydrolase, family 10
HWN34_RS28410	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HWN34_RS28445	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HWN34_RS28450	COG3279	Response regulator of the LytR AlgR family
HWN34_RS28460	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWN34_RS28465	COG3275	phosphorelay sensor kinase activity
HWN34_RS28530	COG0583	DNA-binding transcription factor activity
HWN34_RS28540	COG1053	succinate dehydrogenase
HWN34_RS28545	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HWN34_RS28550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWN34_RS28560	COG3360	Dodecin
HWN34_RS28565	COG2182	Extracellular solute-binding protein
HWN34_RS28570	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HWN34_RS28575	COG0121	glutamine amidotransferase
HWN34_RS28580	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HWN34_RS28600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWN34_RS28605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HWN34_RS28625	COG2837	iron assimilation
HWN34_RS28635	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HWN34_RS28635	COG1796	DNA polymerase
HWN34_RS28670	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HWN34_RS28695	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HWN34_RS28705	COG0254	rRNA binding
HWN34_RS28710	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HWN34_RS28715	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HWN34_RS28720	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HWN34_RS28750	COG0477	Major facilitator Superfamily
HWN34_RS28780	COG3119	arylsulfatase activity
HWN34_RS28800	COG4948	Mandelate Racemase Muconate Lactonizing
HWN34_RS28870	COG0464	growth
HWN34_RS28890	COG3655	Transcriptional regulator
HWN34_RS28900	COG4257	antibiotic catabolic process
HWN34_RS28910	COG0803	Belongs to the bacterial solute-binding protein 9 family
HWN34_RS28920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HWN34_RS28925	COG1121	(ABC) transporter
HWN34_RS28930	COG4608	Belongs to the ABC transporter superfamily
HWN34_RS28935	COG0444	Belongs to the ABC transporter superfamily
HWN34_RS28940	COG0601	transmembrane transport
HWN34_RS28945	COG0747	negative chemotaxis
HWN34_RS28955	COG3458	cephalosporin-C deacetylase activity
HWN34_RS28965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWN34_RS28975	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HWN34_RS28980	COG0363	glucosamine-6-phosphate deaminase activity
HWN34_RS28985	COG0590	tRNA wobble adenosine to inosine editing
HWN34_RS28990	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HWN34_RS29020	COG2201	protein-glutamate methylesterase activity
HWN34_RS29025	COG0300	oxidoreductase activity
HWN34_RS29035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HWN34_RS29070	COG0745	RESPONSE REGULATOR receiver
HWN34_RS29075	COG0243	molybdopterin cofactor binding
HWN34_RS29080	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWN34_RS29085	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWN34_RS29085	COG2146	nitrite reductase [NAD(P)H] activity
HWN34_RS29105	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HWN34_RS29110	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HWN34_RS29115	COG1984	allophanate hydrolase subunit 2
HWN34_RS29145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWN34_RS29155	COG1120	ATPase activity
HWN34_RS29180	COG1132	(ABC) transporter
HWN34_RS29185	COG1132	(ABC) transporter
HWN34_RS29190	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HWN34_RS29200	COG0110	maltose O-acetyltransferase activity
HWN34_RS29215	COG0242	peptide deformylase activity
HWN34_RS29235	COG1349	DNA-binding transcription factor activity
HWN34_RS29250	COG3395	kinase activity
HWN34_RS29255	COG0235	Class ii aldolase
HWN34_RS29295	COG4608	Belongs to the ABC transporter superfamily
HWN34_RS29300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWN34_RS29310	COG0431	NADPH-dependent FMN reductase
HWN34_RS29325	COG1116	anion transmembrane transporter activity
HWN34_RS29335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWN34_RS29345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWN34_RS29350	COG0583	DNA-binding transcription factor activity
HWN34_RS29360	COG1028	Short-chain dehydrogenase reductase Sdr
HWN34_RS29375	COG2124	cytochrome p450
HWN34_RS29380	COG1174	glycine betaine transport
HWN34_RS29385	COG1174	glycine betaine transport
HWN34_RS29395	COG1125	glycine betaine transport
HWN34_RS29395	COG0517	IMP dehydrogenase activity
HWN34_RS29420	COG1960	acyl-CoA dehydrogenase activity
HWN34_RS29425	COG1960	acyl-CoA dehydrogenase activity
HWN34_RS29435	COG0601	transmembrane transport
HWN34_RS29440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HWN34_RS29445	COG0444	Belongs to the ABC transporter superfamily
HWN34_RS29450	COG1124	(ABC) transporter
HWN34_RS29460	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
HWN34_RS29465	COG2318	DinB family
HWN34_RS29490	COG0277	FAD linked oxidase domain protein
HWN34_RS29495	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HWN34_RS29505	COG2271	Major facilitator Superfamily
HWN34_RS29555	COG1028	Short-chain dehydrogenase reductase Sdr
HWN34_RS29635	COG0604	alcohol dehydrogenase
HWN34_RS29635	COG3321	synthase
HWN34_RS29635	COG0604	alcohol dehydrogenase
HWN34_RS29635	COG3321	synthase
HWN34_RS29655	COG2124	cytochrome p450
HWN34_RS29660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HWN34_RS29700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWN34_RS29710	COG1129	ABC transporter
HWN34_RS29740	COG3483	tryptophan 2,3-dioxygenase activity
HWN34_RS29745	COG1028	Short-chain dehydrogenase reductase Sdr
HWN34_RS29750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HWN34_RS29755	COG2151	metal-sulfur cluster biosynthetic enzyme
HWN34_RS29760	COG3396	Phenylacetate-CoA oxygenase
HWN34_RS29770	COG3396	Phenylacetate-CoA oxygenase
HWN34_RS29785	COG0604	alcohol dehydrogenase
HWN34_RS29795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWN34_RS29845	COG0515	serine threonine protein kinase
HWN34_RS29880	COG1404	Belongs to the peptidase S8 family
HWN34_RS29905	COG0583	DNA-binding transcription factor activity
HWN34_RS29925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWN34_RS29925	COG4221	oxidoreductase activity
HWN34_RS29925	COG3321	synthase
HWN34_RS29925	COG0300	oxidoreductase activity
HWN34_RS29935	COG4335	DNA alkylation repair
HWN34_RS29960	COG0477	Major facilitator Superfamily
HWN34_RS29990	COG3246	L-lysine catabolic process to acetate
HWN34_RS29995	COG1250	3-hydroxyacyl-CoA dehydrogenase